<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR44</accession>
    <name>A8PR44_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732825.1">
        <property type="nucleotide sequence ID" value="XM_001732773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR44"/>
    <dbReference type="FunCoup" id="A8PR44">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR44"/>
    <dbReference type="GeneID" id="5857131"/>
    <dbReference type="KEGG" id="mgl:MGL_0600"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0600"/>
    <dbReference type="InParanoid" id="A8PR44"/>
    <dbReference type="OMA" id="WMDMDIS"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725331" evidence="7">
        <location>
            <begin position="27"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="148"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="384" mass="42977" checksum="869207408C6958CB" modified="2008-01-15" version="1">MLYWPAKYLTIWLLVCIVCLLPLVAAAKDFYRVLGVKPHASEREIKSAYRKKARHMHPDKHPDKAEAFMEVSEAYQVLSDPELRRVYDSHGADAALQHQSRKENGHGDPFDLFRQFFGGGPSRSNDQTPKGASKIYQAEISLSDLYLGRSFTLVHERHVVCPSCFGSGAHSTADIRTCTQCRGSGVQILRQEIMPGFVTSMQSTCPHCQGQGRMIARTCSRCHGQKVLPDTTDIEVEVDAGAREGAEYIFEGMADQDPDMDAGDVIVKVHTTTSPGDFRRMGHNLYYIYTISLHDALLGFDHTLSHYDGHPIHIKRASVTQPGQVIRIPSEGLPIPYDEKDLAHGKEHGDLFVEFQVILPQVHDHKTRKSLASLLEQPIAHKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRE5</accession>
    <name>A8PRE5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732259.1">
        <property type="nucleotide sequence ID" value="XM_001732207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRE5"/>
    <dbReference type="STRING" id="425265.A8PRE5"/>
    <dbReference type="GeneID" id="5856565"/>
    <dbReference type="KEGG" id="mgl:MGL_0034"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0034"/>
    <dbReference type="InParanoid" id="A8PRE5"/>
    <dbReference type="OMA" id="WHIRAIR"/>
    <dbReference type="OrthoDB" id="428342at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="272" mass="30661" checksum="FC84E7FDDF88262A" modified="2008-01-15" version="1">MESLWKVLESVQVYNEHRTQLVPLVESYHVPFALHVFHAQEKLHNGEREQGVELMWKHLQFANRKAKETSTSNIWQTRAIRVTLLLASLLIERDEISAADTLVQSLVVKLDASNAKDPVLSLALARLFWEIGDHKQASAMLNCARSSSVSEQHDMHAALVHHCVLGEYLNQPHMEPTALSTVKDFESSHVCQSLTNTMSMEAFFQGQIGESIRILEQLLHAHPTTFATSSSLASNLLTLHSLSSNDVKEEKQRVVRFLVQWAGDDPSCVHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRE6</accession>
    <name>A8PRE6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FUN14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732260.1">
        <property type="nucleotide sequence ID" value="XM_001732208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRE6"/>
    <dbReference type="STRING" id="425265.A8PRE6"/>
    <dbReference type="GeneID" id="5856566"/>
    <dbReference type="KEGG" id="mgl:MGL_0035"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0035"/>
    <dbReference type="InParanoid" id="A8PRE6"/>
    <dbReference type="OMA" id="FYELTFG"/>
    <dbReference type="OrthoDB" id="163794at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF10">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23846" checksum="57B046B12AAE0AB0" modified="2008-01-15" version="1">MAMNMFRRVPFSLPIISQAARLSSPVRLSIRPTACSFRSFSMAANVPRVSASARSGFIASTGILAGGSLLLTSAWFGYSSKPAECEPTDLPAPAINASSGNTSNPKSIVNLYQLSFGTVCGLCAGIFIKKGLKVIAFLLGGVYILMQYLASKRMIRVDWSSLKNTYTSSVNRLAGPADTSKSNFEQMPLVRIWKRTVDFLTADFQERATFIAGLVLGLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRF8</accession>
    <name>A8PRF8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate kinase FGGY C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732268.1">
        <property type="nucleotide sequence ID" value="XM_001732216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRF8"/>
    <dbReference type="STRING" id="425265.A8PRF8"/>
    <dbReference type="GeneID" id="5856574"/>
    <dbReference type="KEGG" id="mgl:MGL_0043"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0043"/>
    <dbReference type="InParanoid" id="A8PRF8"/>
    <dbReference type="OMA" id="RPRENHA"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="4">
        <location>
            <begin position="211"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="515" mass="56362" checksum="3347CC13DD8DE802" modified="2008-01-15" version="1">MSITPPSITKMIPDEADRNVILWADHRAEEEARLINSQHHKVLDYVGGTMSLEMEMPKILWLRRHWPAAKFDSAQFFDLPDYLTFRATGSRARSNCSLVCKCGYIPPGTAGSKIGWQPDFLERIGLGCLGPHYDALGGIPGKQGLVLTAGMPVGAGLSEEAASELGLLPHTPVSSALIDAYAGWVGTAAAKSLGRDETTHTSLHDAQSRLVAIAGTSTCYCIQSEQGVHVPGVWGPYHHAVFPHRWINEGGQSSTGQLIDAVLQTHPAYATTLSEAHARQCSVYSLLEESLEAQMQASELPVTSPSSYALLVRYMHMYPDFYGNRSPLADTSLRGMLSGLDLDRSRADLARKYLLTLEAIALQTRHIVDEMNRSGHKVETIYFSGGGQARNQIYAHLVADICGLRVQMPTEASASVTVGSAILGQMAALVTLERSKLVRSETPILSSQTDAEATAQQYAGTLWNLMEASTKPGQLIEPTNNLSLHKLFDTKYRIFLECIDLQRRWRTEIDSVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRQ2</accession>
    <name>A8PRQ2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732328.1">
        <property type="nucleotide sequence ID" value="XM_001732276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRQ2"/>
    <dbReference type="FunCoup" id="A8PRQ2">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRQ2"/>
    <dbReference type="MEROPS" id="M24.009"/>
    <dbReference type="GeneID" id="5856634"/>
    <dbReference type="KEGG" id="mgl:MGL_0103"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0103"/>
    <dbReference type="InParanoid" id="A8PRQ2"/>
    <dbReference type="OMA" id="EPGMILS"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="314"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="8">
        <location>
            <begin position="546"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="67669" checksum="A09D58EC788A5C1B" modified="2008-01-15" version="1">MGAVSTGVVRTASLVEQLRNRMQSHNLHAYIVPSEDEHASEYPSDADLLRGYITGFNGSAGCALVTQKEALLFTDGRYFLQASQQLEPGVWTLMRMGEPGVPSWDNWLVENMPANSRVGVDPKLISAEDAHTLEEALKLSSSALVPLHDNLVASVWPDRPARPHEPIFPLPESITGQSVATKLQALREEMRKQQASAFVATMLDEVAWLLNLRGNDVPFNPVFFAFAIITQDACHFYVDESQLSEDARRHLGSQVTVRPYASFYTDLAALKQRVLIGKRASWAVYDALGAENAHIVRSILVDQKSIKNPVELDGFREAHLRDGPALVSFFAWLEAMLTTEGQVVSETHAAKQLTAFREQQEDFRGLSFPTISSTGPNGAIIHYAPPEEGSPPIDPNNLYVCDSGAHFTFGTTDVTRTLHFGTPTAEQRRCFTRVLQGHIAIDQLIFPTHVTGYVIDALARAPGWRDHLEYRHGTGHGVGHFLNVHEPPMGIGTRPVFNETGLQPGMVLSNEPGYYLDGHWGIRIENLVIVQPHFLSNGAEPPTSKGFLRFERLTMCPIQTRLIDTGLLSPDERAWINAYHDEVLTKLRPRVEKDARALKWLERECAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRS3</accession>
    <name>A8PRS3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732341.1">
        <property type="nucleotide sequence ID" value="XM_001732289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRS3"/>
    <dbReference type="STRING" id="425265.A8PRS3"/>
    <dbReference type="GeneID" id="5856647"/>
    <dbReference type="KEGG" id="mgl:MGL_0116"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0116"/>
    <dbReference type="InParanoid" id="A8PRS3"/>
    <dbReference type="OMA" id="DAVFPGM"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF8">
        <property type="entry name" value="7ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="237" mass="25240" checksum="EFFCFF82F8DF467D" modified="2008-01-15" version="1">MNELKEAAQQMNQVAPSQGTWPPGTACIPIQADLASKAGCDALASELMKRESELDILVNNSGLTWGGPRDDFPEDKGWDKVFHLNVKSQFYLTVALIPLLEKNKTNTHHASVINVASVAAFMPQAGGPLAAPGTGTYSYQPSKAASVHLTRTMAVDLAEKNILVNAVCPGVFPSRMTAWSLGEYKQVLEDAQPTGRLGTPEDIGGLLLFLVSRAGSHVTGAAIPLDGGQVVQFYPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRT1</accession>
    <name>A8PRT1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732346.1">
        <property type="nucleotide sequence ID" value="XM_001732294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRT1"/>
    <dbReference type="FunCoup" id="A8PRT1">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRT1"/>
    <dbReference type="GeneID" id="5856652"/>
    <dbReference type="KEGG" id="mgl:MGL_0121"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0121"/>
    <dbReference type="InParanoid" id="A8PRT1"/>
    <dbReference type="OMA" id="NCRTFQE"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="382" mass="42502" checksum="ABD553E0134F459E" modified="2008-01-15" version="1">MMGARRAGKTSICKVIYESFQPSDTLFLTPTTRTQIIDIDAFYPLELWDVPGSMLMKAGWTGGLRAPVSSASAAPSTAKNSGTTASAPSDSTSTSVPNLELDVPWASVSALIFVIDAQDDYFDALVRLNALIITGFLKNRLIQVHVFINKVDGLSDDYKYDTQRDIEQRVYEGLIDSSHELQDILDDSTRLDQLVSLRFHLTSVFDSSVFVAFSRIQQQLMQGPSPTEKLCHSPAFDAQPMVSLSEALETACNLLCASCYFEKVYIFDVPSRTFVGCDTSPFDAPLFDTLFRYIQFLRQFSDLYANIPDVDHSEPSVRTRDWSTSVMRLGFDTSVAFWQLNHHLALLAVVNSNIQQCNTSVLDYNVGLFRSSIVQLARLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRU0</accession>
    <name>A8PRU0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Squalene monooxygenase</fullName>
            <ecNumber evidence="4 10">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0127</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 10">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="4 10"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732352.1">
        <property type="nucleotide sequence ID" value="XM_001732300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRU0"/>
    <dbReference type="FunCoup" id="A8PRU0">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRU0"/>
    <dbReference type="GeneID" id="5856658"/>
    <dbReference type="KEGG" id="mgl:MGL_0127"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0127"/>
    <dbReference type="InParanoid" id="A8PRU0"/>
    <dbReference type="OMA" id="AKRTFYW"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="11">
        <location>
            <begin position="186"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="564" mass="61790" checksum="C1014DB7458B108B" modified="2008-01-15" version="1">MVHEDAQARESAHANNHVDNRSGYDVILVGAGIVGSALATSLARAGRRVLVLERDMSEPDRIVGELLQPGGVRALQLLGLEDALDGIDAVPAEGYDIFLSPREHVKIQYPHMAELPTRYGRSEPLGPDMHYAGRSFHHGRFIMALRSRMQAQPNVSVVEAAVTSLVHDPRDRRVVGVRTATSDVYHAPVTIVADGIFSKFRKEYGGAYKPEIRSHFVGIELPPESVLTPKHGHVILNQKAAKRVAPGKSVGPALVYQIGSDATRLLVDVPGPVLPSVSNGDLQRYLSEVVVPCLPEKIGVALTKRLADHTRLRTMSNSFLPPSMQGMLQHQRGLILVGDAMNMRHPLTGGGMTVAFWDCVYLTHILGSGAWSPLDGFDNTFPVPASARDLSDWTSLKPLLRAWHWKRKKLASVINILAMALYSLFGVPNDNLTILRAGCFRYFECGGDCVRGPISLLGGLAPDPMLLVYHFFAVAVYSVRLMFRGDLYATGGEKSQVQRPPLTTWPLLCVRALVVMAYACYVIFPIIYTEIRTNIATNQRAWLWPSCLALGVAVVALGASRYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRZ3</accession>
    <name>A8PRZ3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732385.1">
        <property type="nucleotide sequence ID" value="XM_001732333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRZ3"/>
    <dbReference type="GeneID" id="5856691"/>
    <dbReference type="KEGG" id="mgl:MGL_0160"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0160"/>
    <dbReference type="InParanoid" id="A8PRZ3"/>
    <dbReference type="OrthoDB" id="3366922at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033349">
        <property type="entry name" value="ATRIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28594">
        <property type="entry name" value="ATR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28594:SF1">
        <property type="entry name" value="ATR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="828" mass="92105" checksum="220364ECBC399AF7" modified="2008-01-15" version="1">MSEDEGDDYFHDEWWESLAIDQLMDSQLLAVEQEAVEQQQQQQQGLEAQAAWTPSVHDKSHENQEVDEVTTTSLRAQLDELRVLYDKQAELVRQLRQEAQQKQGEVAVVRANLNRTQQQHVGLQQNQNRMEQEYRERIESLQQENRRQLERMETAAAFRRIEQDSSRSAWPSTARRRAPILFDTSKPTPGPSTQDPLLSTPTRSRRVQVKHMPPTTSPLSLTRRKRPIPYVNEEPSSPSKSRSVNAARMTPRAFPRFENTFLPPHPTTNEPVAASGSVVSERVPRNVPVSAVPLIRPALPQTTPVTERPGSPTTSIPARSPSPSSSTPTPSPEAERLLESQDGNDAPDTRDHILTAIFTLQTRWITHVLCHPCRASCIYPIITSEPGAPSDSASQQQSKLQRPLQSFPSLPHRQPESMLLYILTEELPTQTLPGVRTRYRRAADLLWQSVLRGSSYAAFFSEWEPVVRQAMRACQGADPSRQLHSIVQQVWSELSHHLYEAVAVAIRIITGIFLHLSMTESICRMLAWMASLGIAHTAFVPHITKRVGGLPWVTATQVLNVTTSQYCDATTPPAASSSQTAQVPVTPKHVRSDASTPTSMMQIMIECVRKASTRTDLSSLNASVMRTCSSAHVSGNAGPLSTPQQARHMVLLSVLRLCKVIAWTVAPQGFQDLHPFLQSPGVVLALLDTPASESSVLIHTLQLCVMTVSDPLTLHICLSAQFDTTWQAGIPPRLSQARFPVLDVLAKHLVDRRGDCAPQMAHEIHMSILYFLTQAARWPDTSIMLAECVPLLPALIQCLSWDVALVWNTEPVPASPAATYAETYVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS56</accession>
    <name>A8PS56_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0197</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732422.1">
        <property type="nucleotide sequence ID" value="XM_001732370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS56"/>
    <dbReference type="FunCoup" id="A8PS56">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS56"/>
    <dbReference type="GeneID" id="5856728"/>
    <dbReference type="KEGG" id="mgl:MGL_0197"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0197"/>
    <dbReference type="InParanoid" id="A8PS56"/>
    <dbReference type="OMA" id="LHVLMMA"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="142"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="660" mass="73897" checksum="AFBC9C682A56D87E" modified="2008-01-15" version="1">MELIPSRRVNDDLQLVLRTKQHLVVYDALSREVAVRPNEAGPHRAAIPDSKCLAVKQEGASFQTASQPLQSCPFCRRPWNASIPQQTPLYSHSDWMHESNEDVIVAPHYFRLLSQASTRTDDMSNGESIGQETNEGYYERFFIEIRQLGRGSRGTVFLCQHVLHGHALGTYAVKKIPVGDRCDVLSQSLGEVHLMEELIHPNVIHYKHAWVEMAQLSLFAPRVPTLHVLMMAANGGSLSDWIAARSGTISSNEELLSTPRTYVERLKAEFRERRHSTEKNNLGTPSSRTGMHFLREDEVVQLMKDITYGLDFLHDRGILHLDLKPGNVLLHWDEDALFPKALLSDFGSSLPLHENWVRKRTGNTGTMEYMAPEAVVSHEGQLAELSSKADIWSLGILLYMLIFFDLPYTQVDDIDQLREEISAYTTLQAAIQNRGLSRRFALVHPALTLLLAQMLQIQPEKRPSCRNILNVLERYPDISGASAAPSANATSALSPHVYTPHTSSALSNSTASSSQTLASSLQAPSSRSLTVNALSSSFPKPRSYAMTDPQTTTSSRKVGYAMQTTLLVPLVVVIAYAQTVVVDRICTWHGSYHAWIRYLCTFLALLQVAFWYVHIENSHFSTSSRPIIWHAVDMRLVLPCAFLALILLMPACSLTTQFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSD4</accession>
    <name>A8PSD4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732462.1">
        <property type="nucleotide sequence ID" value="XM_001732410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSD4"/>
    <dbReference type="STRING" id="425265.A8PSD4"/>
    <dbReference type="GeneID" id="5856768"/>
    <dbReference type="KEGG" id="mgl:MGL_0237"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0237"/>
    <dbReference type="InParanoid" id="A8PSD4"/>
    <dbReference type="OMA" id="NCARSWV"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13563" checksum="7DEE8D74C57C6F8A" modified="2008-01-15" version="1">MSSTGAPTRSNRQQCWDSRDAYYACLTKHSIQVPPGTDMTGTKGPLGSGAFAEPRRSEDERMRITMAERDADPCAELRNVYEGSCAQSWIEYFNKRRVLEERQKAFYAMAEANAAKRQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSE7</accession>
    <name>A8PSE7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0244</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732469.1">
        <property type="nucleotide sequence ID" value="XM_001732417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSE7"/>
    <dbReference type="FunCoup" id="A8PSE7">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSE7"/>
    <dbReference type="GeneID" id="5856775"/>
    <dbReference type="KEGG" id="mgl:MGL_0244"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0244"/>
    <dbReference type="InParanoid" id="A8PSE7"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="55"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="215"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33797" checksum="EE34BE22DE2C3DF5" modified="2008-01-15" version="1">MSRPEHQAPPEIYYGDTEARKYTANTRNQEIQAEMTLRAIELLALPPHRHPALVLDIGCGSGLSGEILTELGHEWVGFDISPSMLSVGLERDVEGDMILADAGHGCMFRAGSFDGAISISVLQWLCNADTSYNSPAARLSTFFSTLYASLSRGARCVFQFYPESDDQVTFIMSQATRAGFGGGLVVDYPNSVKAKKIYLVLWVGGEMLVGPNGEGQGVKQRLPDALDFDENDSTVRHETRKMQDVRKDRHRKNKKIESSKAYIQRKKDLNRSRGKSVRAPCLITDLKDVPNDSKYSGRRRRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSM2</accession>
    <name>A8PSM2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732507.1">
        <property type="nucleotide sequence ID" value="XM_001732455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSM2"/>
    <dbReference type="GeneID" id="5856813"/>
    <dbReference type="KEGG" id="mgl:MGL_0282"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0282"/>
    <dbReference type="InParanoid" id="A8PSM2"/>
    <dbReference type="OMA" id="ARHMAYM"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="68148" checksum="24812CF9AF40FF53" modified="2008-01-15" version="1">MNSSNIELAVTSPFSESWGQYQLHPEDLPWRKASEGRLCGKWIRALWGNELYQERRSSSTGRSDDMVTMLSLTLPPALDITKFFELFKLSCMHARFIHPILAGTIETNVLQIPLMPCLVYEELHTFEQVQSWSDTVMFIHRCETDEERAQSREERLEFMRNKIGLRPLPLTQHVKEWHWVLFGRAEDQSHVALFVYSAHAVSDAHSELILMKEQLEYVTSALEAPFPLPEAHSLHPATLAWGTEVTRLTPSLLELVGVPLDSFSDETALRRVRRVLAHPFLRLDLGRPKDGSNLTDTLHDRIQFTAEETAAIHKAARAHGWSVTHIVDAARHMAYMELRRSYLESWHWNPIPEKLHVNFLVPANARCLISETYKHLQQTFVGNATEGFTTVLPLMDPYFVSAQDELMTSEKPLHELSQVRTLAYVTQKLAEQYYEEKPLGMERIVSETPTFVMAGVFSPLYPFDNLAPEGFSSVGAIDTLLPCNFHMPSYTEPITVDDWGVGVIMSRHLSSLQFSMHMWTFRQQLNLSVVHTPHISKARTELFLDTIHRTLKLFLMAFEQHGKPIDIPSSPPTPFVSRTLFQRAISWCQSWFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSS5</accession>
    <name>A8PSS5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0308</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732533.1">
        <property type="nucleotide sequence ID" value="XM_001732481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSS5"/>
    <dbReference type="FunCoup" id="A8PSS5">
        <property type="interactions" value="699"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSS5"/>
    <dbReference type="GeneID" id="5856839"/>
    <dbReference type="KEGG" id="mgl:MGL_0308"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0308"/>
    <dbReference type="InParanoid" id="A8PSS5"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP45319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="276" mass="29800" checksum="09BD36C73EA8A860" modified="2008-01-15" version="1">MARGGMPMSTHEQGPVDRATPDFLVVILDLNAYAWQHVSETAKESEPSSTPSQQADVAFSTLKDTILSVLVFLNAYTAMQHGNGLVVYGAATGTARLLYSSSPHVHPDTHSRRTPQDTHVSACLPFKQMDDAVFHGMRALFDDARDGARGPVGMVRALALALCHMHRLSTVLSESTTTDPHSGALGARTRRGRNTSFLQRILVLSATPDVSAQYVPMMNCIFSAQKQGIQVDARSCFPRSMMLISVPPVSVTGITLTSDMCALFVSAFSVPRVIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT06</accession>
    <name>A8PT06_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_0347</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732572.1">
        <property type="nucleotide sequence ID" value="XM_001732520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT06"/>
    <dbReference type="FunCoup" id="A8PT06">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT06"/>
    <dbReference type="GeneID" id="5856878"/>
    <dbReference type="KEGG" id="mgl:MGL_0347"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0347"/>
    <dbReference type="InParanoid" id="A8PT06"/>
    <dbReference type="OMA" id="VLSEAMW"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="454"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="698"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1034"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1044"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP45358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1065" mass="119282" checksum="588649A41B9D68F7" modified="2008-01-15" version="1">MPPKFVEGTAHISASDIKDSAAAEAAAAGPEQEMKAALFDEAQLLSTGDKKAAVELTNLVKIEGPSALRNLGIEDVIKKGLSDKKNVHGREGACMLVMTLFDEGVGHEVEPFIMNGVFETLAEAMGDKEKTVRQRAEDALLLVIRNMSTWGVPQVLRALLHQMRTAGKWQVKTGCIRLLEELIQISPEIVARLMTDIIPVMAEVIWDTKSDVQKASRAALEKLCALVSNKDIERFIPALIQSLIHPVEEVPKTIQLLSATTFVQEVDSPTLALMTPLLSRGLTERPTATKRKVAVIIDNMSKLVDNERTVRPFLPKLLPGLIKIETTVSDPEARSVVQRAINTLRQVGKVTGDGSDVKPIEDVDLSKTIELVNEQLKKNGLSGPDTLVHYVAQLVTNLANFRMFEPDEWEGTLSRYLSLFRPSSQEKSHTIVHELLRMLAKSTGEEVEVFDDEEEGEDLCNCQFSLAYGAKILLNTATLRLKRGHRYGLCGRNGSGKSTLMRAIQNGQVEGFPSPEEVRTWYVEHDLDGSEGDISIIDFIQSDKRLNVDRETAAATLKEMGFDEQRQAGPITALSGGWKMKLALARAVLFKADILLLDEPTNHLDVINVAWITNYLKQTSATSIIVSHDSKFLNDVCTDILHLNRFKIKRYPGNLDAFVKRVPEARAYVELNSGEDYSFKLPNPPLLDGVKTKEKSLVKMRDVVFQYPNTPAPQLRGVSMQLSLSSRVAVLGPNGSGKSTLVKLVVGDTEPNEGELWKHPNLVIGYVAQHAFHHIDQHLDKTPLEYMLWRYQTGEDLEEHMKATRQLTPEEEEAMKHGAIYEHEGVKRVIEDIVGRKKLKNSFQYEVSFKNMSSADNLWLSRDELMRRGFEKKIMQVDSREAQKAGMLRPLVRREIEKHFEDFGLEREFTSHNTMRGLSGGQKVKVVLGAATWRMPHIIVLDEPTNFLDRESLAALIAAIQSFEGGVAIITHSQEFSEGTCKEIWRMQDGTLHASGHNWVEGQGSGERIDKKKNDEEEVKYDALGNKIVEEKKKKKLTSSEARKAKKDRMARRKRGEEVFSDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTL6</accession>
    <name>A8PTL6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732669.1">
        <property type="nucleotide sequence ID" value="XM_001732617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTL6"/>
    <dbReference type="FunCoup" id="A8PTL6">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTL6"/>
    <dbReference type="GeneID" id="5856975"/>
    <dbReference type="KEGG" id="mgl:MGL_0444"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0444"/>
    <dbReference type="InParanoid" id="A8PTL6"/>
    <dbReference type="OMA" id="MFLKINM"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="738"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="862" mass="94053" checksum="B7AD32756C91D143" modified="2008-01-15" version="1">MNPTTHAYVAPPSHLQFMTVDWVVDGRRERVKIEKNEAHMRRFAEQMQEHGTLAWHGLTTFAERLPFSQSITMSLYTLSGWFGSLLGSMRAPLFSTAESGVVVLVGALIGINMALITVVTEWASDLKRGYCSAGWWLNKSFCCWEQMDPAGPGANLPKGVAAVAAAAAAGLANSSSTSPSPMHNEVLGLRADITLPSSAKSAHTCPEWVDWAEWTLPAWLAYITTSALLAGACAILVRHYAPYAAGSGISEIKCVLAGFSIRGFLSAKTLLIKSLGLPLAIASGLSVGKEGPAVHVACCIGHTAAKVLRWLVPSHSKLRELLTASSAAGVAVAFGSPVGGVLFALEFMNPYRTGKLVLFQVEYNHNWYYFEIVFFLLIGVFGGLYGEYVVRFNLQVQRFRRKFLSQYGVQEAVVLALITAMISYFNRFMQLDMTKTLEELFQQCDGASDDDALCQSRMQWSMFTSLCLATGLRFFLVILSYGCKVPAGIFIPSMAVGATFGRSVGILIKALQSTFPSLFLFASCPADEPCIIPGTYAMLGAAAGLAGVTRITVAVVVIMFELTGALTYILPIMLVVSTSKLVADMFSKGGISDQSIKFNGYPFLNLDDHVRDMPVGEFVKSVPDVLYATGMPLHDVEAYLAKSTYRGFPVVQSESNYNLLGYIERHHLQYAISKAYAQGTLHSDTTCLFQPKSTEAYALTTAQIQSDPAVGTNLAPAVHLSEEEMEIEVGPLQLGDWVDPAPLIVQPQLDLEVVADMFKRLGPRVILVCQNGQLIGIVTVKDLLRHIAMNERVEAEGPNMSSANDTRGDTDFAVGTGELEQLLETSWTWLCSCMSRMPWVRRYVQASEFVPLTTVTTLYENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTU5</accession>
    <name>A8PTU5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732705.1">
        <property type="nucleotide sequence ID" value="XM_001732653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTU5"/>
    <dbReference type="STRING" id="425265.A8PTU5"/>
    <dbReference type="GeneID" id="5857011"/>
    <dbReference type="KEGG" id="mgl:MGL_0480"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0480"/>
    <dbReference type="InParanoid" id="A8PTU5"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="433" mass="48343" checksum="CE80B97CCB878388" modified="2008-01-15" version="1">MVVDLAPILPIEHKLRELSSGPRVDNEPVWQFLDHCEQMEELARKEQRGTEGGNDRNVPLFGLGLDRGRAVPHLGSFLYDGTRKSAIPTEMLINNVGATVEVRISGRMIGLGITEAEWRSEEARLEAEVIERIERDADQGIAPTLALDRATTSIPASDEYFGRWRLGWRGLEHARINREIRLTHAWHERRAQESIRNKRLRRSVSTRAPPRSSPFPVRAVDDAELQRAGWQFWAQPSLEHRKLWGTDVYTDDSDVLAMCVHAGWIEAPHIPGVPEWLCGGGCLPVAKAWKALSVKEAEQTGEPMPEPTPREPIHIVPSATCDLSVILRIAPKLVLYKGCHRGGIKSRSWGNTHDGVSLVVESVELRPPNYATGCGRRSAKTRISHMAKLRQTASQVPPSRSLPLTAKVCTDSRGISLSSLVPCDSRVFWDTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUQ0</accession>
    <name>A8PUQ0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732149.1">
        <property type="nucleotide sequence ID" value="XM_001732097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUQ0"/>
    <dbReference type="STRING" id="425265.A8PUQ0"/>
    <dbReference type="GeneID" id="5856455"/>
    <dbReference type="KEGG" id="mgl:MGL_0742"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0742"/>
    <dbReference type="InParanoid" id="A8PUQ0"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="2">
        <location>
            <begin position="30"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="303" mass="32968" checksum="6F4B984EB9A4875F" modified="2008-01-15" version="1">MCWRCACSWDVRMVVHAREVHLYDQVTGQRFAHADWPDPALGAHVVERRNAKVLVVLAANSVFVLSLPRLDTVHRVQRHVPPGQEVVASTPQVSLERQGDFMELTNGQQLRLWSIFGSLPHAEMPSLFLFTPRSLPLPPGAGATGYIASVAGWLGSSAGQSLSQGGQIDALIGGKRRAKLPNLPPRMVWQKDDDLSTNAAGSAATGIQGQGTGKAGSSQAASTDPNASGAWLASYQRQFLNFASSSARAQASWNMQLLHKRDEILSDLDESMTNLERGAKDFFKQTRNAALKSAAKEKFNSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUT7</accession>
    <name>A8PUT7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dihydroxyacetone kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_0770</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732177.1">
        <property type="nucleotide sequence ID" value="XM_001732125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUT7"/>
    <dbReference type="FunCoup" id="A8PUT7">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUT7"/>
    <dbReference type="GeneID" id="5856483"/>
    <dbReference type="KEGG" id="mgl:MGL_0770"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0770"/>
    <dbReference type="InParanoid" id="A8PUT7"/>
    <dbReference type="OMA" id="ALNMNGF"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="15">
        <location>
            <begin position="9"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="14">
        <location>
            <begin position="412"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP44963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="65630" checksum="7D5488BBB8C33CDF" modified="2008-01-15" version="1">MSTKHVFDDPHGLVEKACRGVASTNSNLRFYAPHKVLYNAAHPRDKVAIIAGGGAGHEPSFSALTGEGLVTVSVSGDVFASPSSAQICSGVDLAPTDKGIVVLVLNYTGDCLNFGLAAEKARSAFAGEGKGREVEMVIVGDDVSVGRSKGGLVGRRGLTGAAFTAKVIGAAAEKGDDVKKVAGLGRSMVNNFVTVGSSLDHCHVPGRSTDPEERGALSQSAIEIGMGIHNETGAKHIENKPSAEDLIKEMLEMLLRDDDPERSFVKFNKDDEPVMIINNLGGMSCLELSAIAAEARVQLERDWNMRPSRVHIGTYVTSLNAPGFNISLLNHKRVSQEYGSDVLELIDAPTGATGWMGAQIGMKNKAALPTAQEQEEEPAKILEQKAKEGHAVGAKPSENKAASVGPKNGDAELVKKVIENVCKSVIDVEPIMTKYDTVVGDGDAGETLRHCAEGVMKALESNQIPLDRATATVLGITEAQESNMGGTSGALYAIYLTGLVQGLQKSTNDPNETASVKHWASAAEHARESLSRYTPARPGDRTLVDALDPFCRTLLKEAESGKNAKDALQAAVSAAKEGAEKTRDLTARLGRATYVGETSEKVPDPGAWGIWALVEGILKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUU6</accession>
    <name>A8PUU6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732182.1">
        <property type="nucleotide sequence ID" value="XM_001732130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUU6"/>
    <dbReference type="STRING" id="425265.A8PUU6"/>
    <dbReference type="GeneID" id="5856488"/>
    <dbReference type="KEGG" id="mgl:MGL_0775"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0775"/>
    <dbReference type="InParanoid" id="A8PUU6"/>
    <dbReference type="OMA" id="CGIRFEL"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="178" mass="20418" checksum="6FFD90B50D8902F3" modified="2008-01-15" version="1">MLSRVLFAPSRALRHQTESLRSFYSCSIRFDSLPTKDMPTATMSRGEFVRPRVADQAMVSRVETPIARPKMPEAVKEYGFEQAPNRYETWSESQRPKSEAMRGPRFEQMDPSSQPQSLSAMELINNYPLQFTQERVTSCDGGDGPLGHPRVFINLDKPEPKPCPYCGIRYQKIDHDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUY0</accession>
    <name>A8PUY0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732203.1">
        <property type="nucleotide sequence ID" value="XM_001732151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUY0"/>
    <dbReference type="GeneID" id="5856509"/>
    <dbReference type="KEGG" id="mgl:MGL_0796"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0796"/>
    <dbReference type="InParanoid" id="A8PUY0"/>
    <dbReference type="OMA" id="EKMREPF"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="48"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="685" mass="75726" checksum="5A036AC38FA48D9A" modified="2008-01-15" version="1">MLKFLRARKWNVHQAFAMLCNCIKWRIEVNVADIIAKGDIGLSKEDPKYEIQGPAEKSYLLGFTQDELIPVISIHVKNHIAKAQPAETMTNFVIVCAETFRSLVTYPNDKVIILFDLGGFGLKNMDWHSLMTILKILEAYYPETLWKLYIHQAPWIFQGIWKAVSPMLDPSVRQKINFTGKPKDLDLIPPHLLEDKLGGQQVDIVRWVPPSPDEKQGLPRDDPQRQKMWKSFRELAVEYENVTKEWIRTNGQDDNLFAERDFHAKRLRLKFIDIDPYLRARTMYHRAGLITKDMFFDFTYKQANGRILKHVVGEEYSRQGLERAIAERSRRSDAQPKMRSSIGRDSAGPGSDSLAAGAGVGGAAAGSVGAGVGAAAVASKRGRARDSSSKRLSRSQISVGESEEPSSRSSRQGFGDGGVPRRQSKTSEEMPSAHSRLPRSSAESFDRVQSRVRSSTEASNIRSQNADVGLGAAAGAGTGVVGGAGAAMSARQAHRSRESKDMMYQPGRQYTPRGGSSAPSINSSMSDDIFVDANEFQPDDSLATYAPRESNASRSHNNNVSVNGRENDAEYIDEETSKGHEGEPESVEEKGLQSKDGPEAGAQSSRDRSSAGDQQSRRSQARRRQRAMNGENEGLAGFPNLANPEQTENIAENNEKMREPFDPNAGRKKPSLISRFMCCGGKSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVI7</accession>
    <name>A8PVI7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731612.1">
        <property type="nucleotide sequence ID" value="XM_001731560.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PVI7">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVI7"/>
    <dbReference type="GeneID" id="5855918"/>
    <dbReference type="KEGG" id="mgl:MGL_0880"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0880"/>
    <dbReference type="InParanoid" id="A8PVI7"/>
    <dbReference type="OMA" id="ERISAYF"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000819">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="744"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1027"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="671"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="956"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="671"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="956"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="973"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1564" mass="174669" checksum="263951E7B10CBF52" modified="2008-01-15" version="1">MVKKKKPQLKSSVQRGFATTSVPKRETPTTNERTNDAIASGATKQREAAESSHPHSHPDGQMTAVATKMTDSHKSKGPTGGEDAFDPEAEELQALQNIVQQVYPKVEKETQRRGKTIQFQQRFSKTLLPVSMDADVCAETLALTRDGREPITKCEEATFLAEERGADGNKDNGDSDGRMILQNMLGMSMPEESEAKALERALTTWELLLSLGFSREQATLALTYAPNLDIEECVAWLVAQLDVRTYRTLSLNVDAPQEYVAPKAASMDDSIPPMYDGYTFTRAEQSEMGSFADDAEKKKKKNDASKLVSAASLDAETLDAIRRGTETVVTSLNALLDTDDALLDVIEHPIEAWCTARIVAMQVDKDRSRRRKMLGGTPDDELAQLVAEAEAQRQLDRLAARTKDVMQQSEIQPQFHRTLATQRFRERMRQREAEEAEKMAAIQREEEAKRQRRSDIEQLDEQTSAGRGDEVANANRYEPSGTDTDADAHGDAKDNAPDPADDDEAGALGDSAGLFEQPDEPGSSGATGDVSVRLRDIPAQSTQRSPRSLLTDVLKAVDPYAQHKFTLVSGKSAVRSQLQIQWNASGGRPPLVDTIKLTKEGCATRALADDYVATIALNCFGRERQVQRHLSKGFRDIWDELEQMRMEQKHAFLRDEVLHVQHLLEHRNRAMRVPETEQALKRDSRRAQPESEPASTPSVRRSRTREAQPQLAEMWAHRASSKAYELMLRGRQDLPIYQARDTILQSVATSQVVVLSGETGCGKSTQLPAYLMEDCLARGEPCKIYVTEPRRISAISLAERVSQEMGEAPRSVGSSESLVGYAIRLESQIGANARLIYATTGIVLRMLESSVLDDVTHIIVDEVHERSIESDFLLIVLKTLMHERPDLKIVLMSATLDAERISAYFGGCPTLAVPGRTFPVDVHYLEDVLELCDDYTLDLNSPYARQTEKLNKVEVQEDVDGDLVDGEEDDGDSHDNEDKAASERKKLDDAGAVSQVNGTTNGPTPRYSAKTIDTLLHLNEHKINYELLTALLERICTEPKYASFSRAILVFLPGMGEIRECLRHLTELRRFQTECQVHVLHSSVATEEQSAAFLPPPEGQRKIVLATNIAETGITIPDITCVVDSGRHREMRYDEKRKISRLVDCFIARSNAKQRRGRAGRVQHGICFHLFTRKRHDDYMDPHPVPEMLRLSLQELALQLKVMPLRIGTSIENALAQALDPPLAVNVQRAVASLVEVEALTPNEDITPLGRHLCHMPLDVHLAKFLLVSVLLGCVDAALSIAAVLNAKSPFLKSMGRETGRGRSAFQTHDSDFMAFAQMFHAWRAAVGRHQGQSFCTAHSLSADVLYQIEELRQQYFAYLVDTGFVRVEASVRNDLARRRARHGRPKLMSIPEHLDVYGQSAPVVTLALVTAMYPKLLQVDENTQQMRTLLNNQPALVHPSSVNARRALGTTSTHFVLYHAIVYSFRLYAWETAVVDDRMVLLIGGEAEFKHTSRSMYIDHNRVRMTTYDAPSLVALRVLRTQLRELFQASFRSPGRPWTRTQHRMMELVLKSLGVPVKPPLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW36</accession>
    <name>A8PW36_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731750.1">
        <property type="nucleotide sequence ID" value="XM_001731698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW36"/>
    <dbReference type="FunCoup" id="A8PW36">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW36"/>
    <dbReference type="GeneID" id="5856055"/>
    <dbReference type="KEGG" id="mgl:MGL_1018"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1018"/>
    <dbReference type="InParanoid" id="A8PW36"/>
    <dbReference type="OMA" id="PFVQQEE"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="130" mass="13958" checksum="EE819B15643D845F" modified="2008-01-15" version="1">MTDRGYGGRGGGGRGSGRGDYSVRGGHGHGGAPQEKPKKEAILNLAKYVDKEIRVKFMGGREVVGTLKGYDQLMTLVMDDVEEIKHDPSNGNTTGERRTLGLAVLRGTNLTLISPVDGFDIIENPFVQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW58</accession>
    <name>A8PW58_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731763.1">
        <property type="nucleotide sequence ID" value="XM_001731711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW58"/>
    <dbReference type="STRING" id="425265.A8PW58"/>
    <dbReference type="GeneID" id="5856068"/>
    <dbReference type="KEGG" id="mgl:MGL_1031"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1031"/>
    <dbReference type="InParanoid" id="A8PW58"/>
    <dbReference type="OMA" id="DAFYIQQ"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="455" mass="48851" checksum="340CF014C6D784BB" modified="2008-01-15" version="1">MGPGAPPPLDAFYIQQASGSFGVPLDVPDVNSYDHTGAAGGALSSSGLPVRGPPPSMSGWGAPSRPGPPPSAHDVQPHEEADVLHPANHGYPGSLSSGIPPMPGSARTFPASMYRPTDPTSHRHMMMESDAARVPRPMQKRQRMSPVPFNDGLDIQSRFRRAGAGPVPGPSPGVSAGPPPGPGRPRLPSRGIPTRRDLDGVPHTDGFPDLLSDPQENPGAPSNDLTSWILGPDDAPQRPQTFSIDPSAYYQQGLTQPSTGLRIDMPGLATPQQALDAPKGLAPIRSQGPSTDEEPLYVNAKQYQRILKRRMARARMEEKRRHMFMLAIKQREEEKNGGTAEISEEWVSGLLALDEEAKKPYLHESRHKHAMRRPRGPGGRFLTTEEIRKRDEELAAQKAQAETPSATNGDTTDSPSQALETESASASTTMTTNDNDPTNSTQQDHVSEAAHAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW63</accession>
    <name>A8PW63_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731766.1">
        <property type="nucleotide sequence ID" value="XM_001731714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW63"/>
    <dbReference type="STRING" id="425265.A8PW63"/>
    <dbReference type="GeneID" id="5856071"/>
    <dbReference type="KEGG" id="mgl:MGL_1034"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1034"/>
    <dbReference type="InParanoid" id="A8PW63"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="228" mass="26621" checksum="DF64034756442DEA" modified="2008-01-15" version="1">MTRLNSYATVIPIIAKSDTVAENELQQYKQRILRDLEFHGIDIVKLPVNEEDDEETIAEVTEIQSRLPFAIVGSNDLVKTADGRIVRGRAYPWGVIEVDNENHCDFVKLRQMLIRSNMEDLRELTQLRYEQYRTKKLLSLGVTQDDSVFSTANPTERQAEARAVHEAKLAKMESDMKAVFQRKVAEKEAKLKQSEEELYARHRQMRAALDQQRQELEEVKRRLQNMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWG6</accession>
    <name>A8PWG6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731825.1">
        <property type="nucleotide sequence ID" value="XM_001731773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWG6"/>
    <dbReference type="STRING" id="425265.A8PWG6"/>
    <dbReference type="GeneID" id="5856130"/>
    <dbReference type="KEGG" id="mgl:MGL_1093"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1093"/>
    <dbReference type="InParanoid" id="A8PWG6"/>
    <dbReference type="OMA" id="RWRNESV"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="20095" checksum="A082640F9FCAD893" modified="2008-01-15" version="1">MSVSSWWRTLSRVLRIGNARYIVGHDLEQNTYMELPSLHGDPKRTRRVVKWKSLSNLSDFNPKEMPIQWDAWMRHTRQHPPTIEELLKDRERQRIVQHNARVLAIRDEAEKAQIEAQRATEHAEALQTQAAREKRRLEIFDASSKSQLGQSEETAHGSGIESATIRPGRRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWI2</accession>
    <name>A8PWI2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731841.1">
        <property type="nucleotide sequence ID" value="XM_001731789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWI2"/>
    <dbReference type="FunCoup" id="A8PWI2">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWI2"/>
    <dbReference type="GeneID" id="5856146"/>
    <dbReference type="KEGG" id="mgl:MGL_1109"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1109"/>
    <dbReference type="InParanoid" id="A8PWI2"/>
    <dbReference type="OMA" id="AAWLPNR"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="8">
        <location>
            <begin position="445"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="674" mass="74398" checksum="F271188C06659156" modified="2008-01-15" version="1">MSRSLRTRPTTLYAREGNSSNIPQVSTRRKVSGEADKEDKVRHRLSVRYASSSVSPGLSYMRGIDSLAPVASKEGTSGGADVPPLPPLPSSMVALSPVPASAETLAKGTWSGASAAGDVVGADVFADENFDARAFVADQVQKQHESGLQTLQTTLGTIQSTTQKQLKEQVFKNYSEFITISREIATFENDMLEFKELLSEWKQLPQQLQIEDPLSEAMWDGGSSSSLQSTHRRSRNSMVDLEQIYKAQLTSLWENIEGSQKFVPFIPGRHLVAETSQFIEVNAATYKPKQAVALFLLDDLLLIAVQRKRQYGSRVHLVAERCFNLSEIVVVDLKDTKDVRNAIKIKHGKESFVYRTERAQDKRALLRAFRGVGEALAAKIKKLRKTGSSSASTRAGAASSSSSSHAGESMLGNGAMDPSSQELGLAERTTPTVPTTHEAQTLGPWLNSVIDDLAVHIALREWEAAVSLVEEGKKRLASRPVSEGPLYLLVENFTSCASELVNAISAELISPYQRKSMVVRDAALLVRLDKGREARDLLLEARSDLLHRRTRQIKYEGDVSLYISELAMLYFTLIKNTGDWYMAAFKDYRMASGFVQWASDQVKSYAETFRRQVYGVDQDPRVVQEAIDITRKCAQLLNDVGLGLGFLLDELLKPGSDALSPGVWHDSTASMQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWT2</accession>
    <name>A8PWT2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731940.1">
        <property type="nucleotide sequence ID" value="XM_001731888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWT2"/>
    <dbReference type="STRING" id="425265.A8PWT2"/>
    <dbReference type="GeneID" id="5856245"/>
    <dbReference type="KEGG" id="mgl:MGL_1208"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1208"/>
    <dbReference type="InParanoid" id="A8PWT2"/>
    <dbReference type="OMA" id="EKPAIFW"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9039" checksum="F252328F6A3ECFC9" modified="2008-01-15" version="1">MAFMSTLTRPFVNTLKYLQWASHARPVVFYSLLLGALGPVSVVVVPKYRAQFGWKPAERIPVSYPLPDRPRSPVSGYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX10</accession>
    <name>A8PX10_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1286</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732018.1">
        <property type="nucleotide sequence ID" value="XM_001731966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX10"/>
    <dbReference type="FunCoup" id="A8PX10">
        <property type="interactions" value="560"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX10"/>
    <dbReference type="GeneID" id="5856323"/>
    <dbReference type="KEGG" id="mgl:MGL_1286"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1286"/>
    <dbReference type="InParanoid" id="A8PX10"/>
    <dbReference type="OMA" id="ECADLID"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="129"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="514"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="572" mass="65201" checksum="493242C23CD0D9BA" modified="2008-01-15" version="1">MEERAHPRREYSYERPRPAPYYLDDARDTSRDDWDRRKERLRLRDESGTWSRQDKRRDSFRRETRRDDTASVLRMVPPRRESPLPRPQLQTPVKVRSGPRPGTLARRARPKPAPLRERTFVGCSNVQAYEVSVKLGQGTFGEVKQGKQISTGRSVALKKVTIYDAKDGLPITALREIKLLKALKHPHIVPVIDMAYRPPTERRKMGEVYMVEPYMDHDLNGLLDNPSVQLPMNQIKLYMRELLEGMLYLHKNRIMHRDMKAANLLIDNQGQLQIADFGLARPFHDPDEAWRSRGWVGSHNYTEMVVTRWYRPPELLVGQRNYGPPIDMWGVGCILAEMITRKPIFKGTSEINQLELISALCGSPNDDNFPGWSKLPGVKNATPSGRPDNNPNVLGRHDFGRYPRVIRQHFTTVIDCGRECADLIDRLLVLDPSKRLTAAEALEHEWFWTKPYPADPASLPKYLPSKEIDRNKREWKMNPNVAPNTGVRPSIMPRPPMLMAPGLPHAPMMPGVPVTTRPPPPAAHLSSSGNGAYPPLPRLPAAPPSGTGYGRQKDYGWYNPSIPRGNAPPRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX29</accession>
    <name>A8PX29_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_1305</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732037.1">
        <property type="nucleotide sequence ID" value="XM_001731985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX29"/>
    <dbReference type="FunCoup" id="A8PX29">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX29"/>
    <dbReference type="GeneID" id="5856342"/>
    <dbReference type="KEGG" id="mgl:MGL_1305"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1305"/>
    <dbReference type="InParanoid" id="A8PX29"/>
    <dbReference type="OMA" id="KVMKGML"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="15">
        <location>
            <begin position="5"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="14">
        <location>
            <begin position="438"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="443"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="443"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP44823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="767" mass="85967" checksum="01E3828F78AF0790" modified="2008-01-15" version="1">MPSTSAVLGFPRIGPQREVKKALEAYWGDKTSAEDLLKVAKEQRLNTYATIKSQGVDFVPTGTFSLYDHVLDTSNTFGIIPEAYAKSGLSPLDTYFAMARGHQKNGVDLPATEMKKWFDSNYHYLVPEFSDKSEFKLNDTKPVDDFVEAKEAGYAPRPVILGPITLLWLGKVSKEAQDPNFDRFTLLSKLNQAYVQLLEKLAAAGATWVQVDEPILVTDKAKELSNEFKETYELFHKSVPSLSILIATYFGRLEDNIDFVKELPIAGLHIDLDRAPEQLEPVLSAISSTKIGLSLGLVSGRNIWKTDLAAALKLAQKAVDSIGADRVQVATSSSLLHTPITTANEKKLKPEVLDWFSFATEKCGEVATIGLALQNSSAASEKLEANAKSIAARRDFEKNSDPAVRERVSNVKPEDFNRKSPFSQRREVQRQFLKLPPFPTTTIGSFPQTKEIRQYRARFSKGEITQEEYEKFLESEIKSVVEKQEALGLDVLVHGEPERNDMVQYFGEQLDGFVFTQNAWVQSFGSRYVRPPIVVSDVSRPNPMTVRWSSYAQSLTQKIMKGMLTGPVTILNWSFPRVDIGRDVQAFQIALALRDEVIDLEKAGIRAVQVDEPAIREGLPLRRKEWDTYLKWAVDSFRLAVGGASNGMNTASHFCYSDFNDIMDSVIALDADMISIENSKSDAKLLKIFQSTKYPNEIGPGVFDIHSPRVPSIEEMTQRIKEMIQFIDPKLLWVNPDCGLKTRTWDECTAQLKAMVAAAQEARKMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXA6</accession>
    <name>A8PXA6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731199.1">
        <property type="nucleotide sequence ID" value="XM_001731147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXA6"/>
    <dbReference type="FunCoup" id="A8PXA6">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXA6"/>
    <dbReference type="GeneID" id="5855506"/>
    <dbReference type="KEGG" id="mgl:MGL_1382"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1382"/>
    <dbReference type="InParanoid" id="A8PXA6"/>
    <dbReference type="OMA" id="ANWPMAP"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42978" checksum="8C6F3971F1CB489B" modified="2008-01-15" version="1">MSSSSGLQRRRGVHTTGGDDDTGEGGVHEKRVSAIEKVSGSGSISTYDSKRGHRLAYDPRDLADENEEQTYPRITLMEEVLLLGLKDTQAYLSFWNDKLSFALRGCILMELALRGRIRVMSGAEQKRRDVGERTIELMNAKLTNDPLLDETIRHIQSSSPTSVAEWMDLLSGETWNMMRLSMQLKQVRERLCKGLVEKGILRTEKRNFLLFDMPTHPIADMSVKDAVRRRVYAITSAQSIHAESLYKEENSAGGRVSLPVTRTMCMVTTALCADVLENALQHLPLQAQEIATQHVEHLVEEFSQWPMAPQTSGGGIPPQGSMDAMLARPINSSRSSVSKKGRQKMGVSIEDLTKAMRHEYDTGAHESAYEVIAAVLSVFLQMDAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXB4</accession>
    <name>A8PXB4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731207.1">
        <property type="nucleotide sequence ID" value="XM_001731155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXB4"/>
    <dbReference type="FunCoup" id="A8PXB4">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXB4"/>
    <dbReference type="GeneID" id="5855514"/>
    <dbReference type="KEGG" id="mgl:MGL_1390"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1390"/>
    <dbReference type="InParanoid" id="A8PXB4"/>
    <dbReference type="OMA" id="DEIFGCQ"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="882"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="938"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="711"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="839"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="990" mass="105425" checksum="973EB12D6301D82F" modified="2008-01-15" version="1">MATSSSSSTVSTPLPAITPSTVVKQKRTLGSTTLRNTKKPEPKELSASASVSTSSQVPAAVPDAAAPATTSAETTVGTNADVGAIPTIPNSAKASKAPSRFRSSFLNKSLRHAIEEKHSSVSDLDAVLNEPSPFHDAADSHRSTDEPIEPSVPVASQETRRARASHTAHSSGPSLDALRTRLESVRRASTTPSTSAFGGNAIASTSERRGSTLSRSAFLDTHFSETSKLSTAMSSWDARNDVHVKTMSEIDADTRPAKHDEQDRTLRRHAMELESDAMQQIAVETAEEMTSDATPASAHESAAKADSQMARDSAFETMPGLALETASKMLPQMQQHPPQRHPSDTALEPAPKSQPAAKSELMSSAQTKNESHFQQEDLFDRVNDHRSEAAEVNTIPSSRPELAPADLMADAAAGSTSDRSAFAYNQPPSRSEISGSPTVVREEDRSIQITRSLADHQMTDSSSHASTALLPASPMSSPQRDHTEKTHSQPSVFQRPITSTTNSATSHIPTPKGRSPGRLREELLSPFRSRIADGSPSRSRLPVSPARLGTSKIPSPSGRKPVQMVDRRGVSPGLQSPASASVMRPASVADTRSVQPGFGSRIKGLFGLSTSSSRPASVLQNSTMTPHHAASVDLELSQPIPGSFQSDVPKPHLSASTSVVPPSHGSGRTTKASTPIKLKPWQSASTSSGHAMRPNSVQSSTRLASSTTASMNSSGGRISSNRKNSVQSSASASSQARPPQRISSVTRPAYAYDAHGKRRKLSQHPLSESTNQDDRVSSEDALKNKLTTSASKFSLSSSAAQPARPLTKTVRASNASITPRPPPTNASARVRTPAGGNTPSRAPAQPPRSSAISTNNVFQQKPAAQPVVGAAELMDAEDLPDVASEYSDSDDEACMRKRKLEPSWTRGRELEDLLLQQSTVDPDEIFGCQVGPVPLDAMLPPRKGDRRRMRHRTSSANWNGPDGLAQWEIDRYNERMGIRSSTATSSMSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXC5</accession>
    <name>A8PXC5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731218.1">
        <property type="nucleotide sequence ID" value="XM_001731166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXC5"/>
    <dbReference type="STRING" id="425265.A8PXC5"/>
    <dbReference type="GeneID" id="5855525"/>
    <dbReference type="KEGG" id="mgl:MGL_1401"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1401"/>
    <dbReference type="InParanoid" id="A8PXC5"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="123" mass="14074" checksum="A290303D9711E71D" modified="2008-01-15" version="1">MKVPATAWRTKEVERLAEQNAIRHKDELPDNMLKYWRFRHSLFTRFNEGILLDKESWFSVTPEALAYRTAVECQGDVVMDGFCGAGGNVIQFAMTCNHVLGIDIDPVKLEMARRNGEHSTVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXD9</accession>
    <name>A8PXD9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731232.1">
        <property type="nucleotide sequence ID" value="XM_001731180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXD9"/>
    <dbReference type="STRING" id="425265.A8PXD9"/>
    <dbReference type="GeneID" id="5855539"/>
    <dbReference type="KEGG" id="mgl:MGL_1415"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1415"/>
    <dbReference type="InParanoid" id="A8PXD9"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="83" mass="9403" checksum="615558714D6F5296" modified="2008-01-15" version="1">MNMLPFLILFGSWLLSLFGTHRSLQVVFVMAIFPMAMNMLQFWIVDSMLLYKPSSTAPPLTGLYEPARQTEPDDVHVTNVSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXE4</accession>
    <name>A8PXE4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731237.1">
        <property type="nucleotide sequence ID" value="XM_001731185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXE4"/>
    <dbReference type="FunCoup" id="A8PXE4">
        <property type="interactions" value="807"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXE4"/>
    <dbReference type="GeneID" id="5855544"/>
    <dbReference type="KEGG" id="mgl:MGL_1420"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1420"/>
    <dbReference type="InParanoid" id="A8PXE4"/>
    <dbReference type="OMA" id="ITCLRIS"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="209" mass="22826" checksum="51ABE04600975A34" modified="2008-01-15" version="1">MWNTLTGERYRRLRGHRGIINDIACTRAGNGCFASASDDGRVLFWDAESRYPVDSLEFGYPITCIEFSNDASLLFVGGVDNAIHAMDLATKNRQYSLLGHKDTVASLALSHAGTRLVSSGLDDSVRVWDVQPFAAAAPAQQPGAPQKSARLIRTLDGMASGFESLLIKARWSPDDEFVACGSADHTSNVWKYVNKHPSGCIFQADCVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXE5</accession>
    <name>A8PXE5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731238.1">
        <property type="nucleotide sequence ID" value="XM_001731186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXE5"/>
    <dbReference type="FunCoup" id="A8PXE5">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXE5"/>
    <dbReference type="GeneID" id="5855545"/>
    <dbReference type="KEGG" id="mgl:MGL_1421"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1421"/>
    <dbReference type="InParanoid" id="A8PXE5"/>
    <dbReference type="OMA" id="AWLENIC"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="681" mass="76738" checksum="94F6D31E7B89B4A0" modified="2008-01-15" version="1">MDSREDEQERGITMKSSAVSLTFKLRTIQKDGSVDAIQDYTLNLIDTPGHVDFSSEVSTAARLCDGALVIVDVVEGVCAQTVNVLRQAWLDGLRTVLVVNKMDRLITELKLTPTEAHHRLLQLLEQVNAVIGGFYAAERMEQDQRWYEERERLREEKEQLHHGDLPQDHTADETDLPEHGEYEDADLYFDPARGNVIFASAVDHWAFRLERFSHMYAQKLGIKEDKIRQFLWGHYYLDPKTKRVLSQKQHDREKRVMKPMFVQFVLDNIWSVYEHTVMERDQDMIDKIIATLQLSIHPRDMRAKEPAMLMQAIMSQWLPLSACTFNAIVRCLPSPAEAQMQRVPRMIRPELGFFASDSELAPTNDLERDLFGSRSGPEAVTVAYVSKMFAVPKEDMPECKRVQLTADEMRERGRLQREAMASTGAEAAASAPNTHEDADETPREKEDGSEEVILGFARLYSGSVSVGETVSAILPKYDPSRAPSDAVNQPYIRECKIQALYMMMGRDLIAVQRVPAGNVFAIRGLDGVVLRNGTLMRAPHGAQLREVVNLAGMKRHATPIVRVALEPRSAADMPRLAEGLKLLNQADPCVEVLFQENGEHVILTAGELHLERCLRDLRERFARCAIQSSPPLVPFRETCVKAANLPPPKTPGALTGHDRGHGFARCRCFYHPCSANALVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXM4</accession>
    <name>A8PXM4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731298.1">
        <property type="nucleotide sequence ID" value="XM_001731246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXM4"/>
    <dbReference type="STRING" id="425265.A8PXM4"/>
    <dbReference type="GeneID" id="5855605"/>
    <dbReference type="KEGG" id="mgl:MGL_1481"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1481"/>
    <dbReference type="InParanoid" id="A8PXM4"/>
    <dbReference type="OMA" id="RWERAKD"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18338" checksum="9D30A5F942665FCB" modified="2008-01-15" version="1">MAPSRTSGAGNALGLTSTKSRAASVRASGKRAAKLSAAAQAVEAVHAAEHAAESAQPKYTREQLKKAEGLPSIHIDDPRFDGIWQRTRKTMGMQPIHSEDLSRIEHILRVFDLDPAFGPCMGLTRLERWERAKDIGNDPPNEVREILLSREGVLDWSSSILDQDAGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXS0</accession>
    <name>A8PXS0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731328.1">
        <property type="nucleotide sequence ID" value="XM_001731276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXS0"/>
    <dbReference type="GeneID" id="5855635"/>
    <dbReference type="KEGG" id="mgl:MGL_1511"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1511"/>
    <dbReference type="InParanoid" id="A8PXS0"/>
    <dbReference type="OMA" id="MISTHFQ"/>
    <dbReference type="OrthoDB" id="2562743at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="505" mass="56577" checksum="CB5697E558A7C667" modified="2008-01-15" version="1">MAELPELTDLSDNASVASSMTMRASSAPIQDAHEYTKLFHRLEALGNVSTRQDRVREKMWKVRGVVESRKNTLARHEKTAETSRAAYERMQRSILTRFAPKSSARGMRARSTATAMTNAQQRMSDLAPLLDRAQAEQAQLEQELESLARQSVEIRIMEERLDDLGRRLCPRGCCGTELDALFFEVDVLLLLTKLVPSEIMREKRAREALLSAEKSGRACLKIMRDVLQMSINLGMANDNRDRLFPGQPSTLTKRSMPLFLRAKVCLGEFYTRVSRARMRQPLVLRAPVMDLADLTRLPGKKNNPFTRDDMQKSIETSYTQCQHVCNYAQSEARFCLMRERALKSFLTELDESIRAAMWRIRKARAYILELDPSAAQLALAHLMDELPKTNDSVKAIAPPRTLDAEDDDGNEIKDADDVDTAAELGSDSDGEVKSQVSKGSVSDTRTMSSVSLASTMTAVSVMSATPELYGATIARLHAKTTATDHELRTDQDDEDLPWHSLALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYM0</accession>
    <name>A8PYM0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731504.1">
        <property type="nucleotide sequence ID" value="XM_001731452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYM0"/>
    <dbReference type="STRING" id="425265.A8PYM0"/>
    <dbReference type="GeneID" id="5855811"/>
    <dbReference type="KEGG" id="mgl:MGL_1687"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1687"/>
    <dbReference type="InParanoid" id="A8PYM0"/>
    <dbReference type="OMA" id="YTEGMCL"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="430"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="651" mass="72760" checksum="166659867FEA9840" modified="2008-01-15" version="1">MDEYSRREWSRFAVEHRGIGTCVASATRDAAGDDQRLAFRKGELVTVLCCFTEPGETTRPDHWFLGSCGYSIGFFQRKDMDAIPKLRSVGTVDARLPPQERLLAPAAKLMGFLVPPDRVLVPLENEDNVQHPPSVNMNQAMDGGQDNKAAVKPETPELVPDALLFASASKSSADARSADGDVFDEYSKEDYETLNSIYDAYFRPTTFIESDMQSTPTKNVLPTSPVSTSSLGDESMTQPRQIDQVLDAMSDEMPNRLLGKDDQVQNSPSRSSMDSHGTKGSPARSATHPPVDLMQPLPMTPTRSRHTVTNNNGSPNRMPRGLSQQPTTSSPLLRSAVSMSPSQSSVRITPCVSSPSSLTSARPSTSSDAPLPRPAPNVYGSPRSKPALDLSEHALPGRAQLFQQWTTILTDRSTMSSKAHKKALQLVHVGVPNPLRGRVWLMLAERHVHPKPGVFERLCRSSMESQQHPDRYSFSTLIEQDLNQCFPLTQPFEGLNGSTRDTIRSILHAYAYYNPSVGYTEGMCLLVGLLLTHLHMEDAFWLLDGIVQGYGLDRIYSGDMRRLRVDNLVIDELVRLVDPSLHQRFRELHIEPIMFLPGWILPIFVRTLPWATLLRVWDLFLCYGYVFLLRTTVAIICPEPRQYHACTKRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYS4</accession>
    <name>A8PYS4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AP180 N-terminal homology (ANTH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731532.1">
        <property type="nucleotide sequence ID" value="XM_001731480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYS4"/>
    <dbReference type="STRING" id="425265.A8PYS4"/>
    <dbReference type="GeneID" id="5855839"/>
    <dbReference type="KEGG" id="mgl:MGL_1715"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1715"/>
    <dbReference type="InParanoid" id="A8PYS4"/>
    <dbReference type="OMA" id="VPNLKHA"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP180 N-terminal homology (ANTH)" evidence="2">
        <location>
            <begin position="30"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="767" mass="83415" checksum="B20A0D4D405215D9" modified="2008-01-15" version="1">MRSESTISVFSYLAGDPSAILLRRVATNGLSEYSYSKVLSRYAHYLDDRILSFRELGYDIVYAGKRDRFARLRKLSVSRGLFKEISMIQRVMSSLLKCSFFSEDLRDEVSEAALQMTLKDLLAYYMAMNEGIINMLEHYFEMSKADAERSLELYRRFCFQTENVLAFLNAAKRYSYQLRSVIPNLKHAPLSLATALEEYLHETDFSKHEVGSRAKASTAEGVKESKTDASSEEPNATTDKPATEKSSPQKASTMAGMNQTSSSSKKALQDFFESLEQPSTPFNSAYASYTGFYTQPDWFGMSAMPTNGVYGMPQVSGNPFGVTPKGSLQPQMTGFNPFSPQMPIIPQQQQPLIPQHTVATTPFDSIFGQMSLNSAQRPQQPHQMQFNPQSIPQQPQPSSQAQSQLMAPSVQQSSMLTQPNAQKQSPLSFSEPAKPAKPSSNNQGVRPQKTGSMNPFSIPSDFDEPNPVVQEPPKPTLNELAMDAWLGKEKKSDHASALPSVQPNQTGIFGHVASEFARPQLAQPKQDSFSKSPDHMLGEGISMSPQIASRMPSHSMGSQVFGDQHTPLYGQPTGQTIQTQPFGRPSLTATPNTLVSSTSSEAPNRRLSALVPPQQGLDISSQRTGLDAFGVGGTPSQGLSPQFSGSVFGTSPISLGDGSVLYPRNSVSGSQAMTSSSGIGSQPSHPSGRLTTFERKPSVPHVSAMSHSDLQSQITGLTGIKPFQPSSAFGASLVSGQLAPKQTSNTTTPTPVEAQQQPQPTQDLLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZD9</accession>
    <name>A8PZD9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="13">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1911</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="13"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730912.1">
        <property type="nucleotide sequence ID" value="XM_001730860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZD9"/>
    <dbReference type="FunCoup" id="A8PZD9">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZD9"/>
    <dbReference type="GeneID" id="5855219"/>
    <dbReference type="KEGG" id="mgl:MGL_1911"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1911"/>
    <dbReference type="InParanoid" id="A8PZD9"/>
    <dbReference type="OMA" id="HIMLTTS"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="664"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="795"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="825"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="14">
        <location>
            <begin position="502"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="957" mass="107188" checksum="19B589571C93259D" modified="2008-01-15" version="1">MSRTSALTKPPQRAPSSIVRRLEFFFVSLVFHLIFTWSIFDVYFHSPVVHPPNRFDATHAVPDAPWAYESPAERLVLIVADGLRADTLFQRHITTALPSWAQQAAAGDQLVYNGTYPAAFSRDEVDATNITRPLYAYAAPFLRSVARGPGIYGVSHTRVPTESRPGHVALIAGMYEDMSAVTKGWKINPLAFDSLVNQSSFTYAYGSPDIVPMFMLGTSQERVEWEVYDEEEEDFTKDAIELDTWVLRRMHDLFERGKANETVDAQLRNPKTVFFLHLLGLDTTGHTYRPMSPEYIGNTIVVDAIVREIAQLFKDYFADDKTAFLVTADHGMSRIGNHGDGDPDNTRTPLVAWGAGVPHARFLPNRQLWRTSYERHWGLDYVARRDVEQADLAPLMAAWLGVPVPANAEGRLPLDLLDAPIDYRARAALATAKQLLEVYRVKYSERAQRMRHFRPYAPLQSKDDGSMPGAARIADAEQVIRDGEFDVAIEESETLAHDALAGAKYLHQYDAMILSTIVVLGYLGLLLYGLTFLAEYADEKSLHAMPQLNTRAMSAAVALLAAYWSKFFLDRAPWMYFVYSGACGAIWILFASRVHLLLDLLKQTSSVWTYVKASIYVVACLAVLEVMVYGYMHRLTWAAILLFLGFFLPFASPMSFKEGHQIGIFLNALCCAGTGWFMSLPTEKDESILLLTCGGMILLALGLLVYAMPRTFLMPPDYLGRDRHAYAMMHARTVEELHVIAAQENEKEPGFDAFWPRTRQALGIELVCLVLSICVTASSARSLAAKQGLPWLNQMTAWVIILVSICVPLVHGFQRARGSLTQPVRERLVLLVFGFAPVFVLLSLRDEVLFYACYTLLILIWGHMEAELARDRTVRMRSKTCSTAASQETLCVTKAVTLPAAQYDLGRFTFGSHVLFPAACWLPSAQAMSHQSPVSICHRCIDSCRCLVRSSWQLCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZK2</accession>
    <name>A8PZK2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pseudouridine synthase I TruA alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730927.1">
        <property type="nucleotide sequence ID" value="XM_001730875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZK2"/>
    <dbReference type="FunCoup" id="A8PZK2">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZK2"/>
    <dbReference type="GeneID" id="5855234"/>
    <dbReference type="KEGG" id="mgl:MGL_1926"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1926"/>
    <dbReference type="InParanoid" id="A8PZK2"/>
    <dbReference type="OMA" id="PCRKIAL"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="255"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="604" mass="66802" checksum="858D227EDE40F5BD" modified="2008-01-15" version="1">MSAREKYGDWSRNQLLRRIAQLEGRAASLGVDVPPAEPADARAAGVASTNAESDTTVQPSICSPAKKQPRHYDVSAQPSRKIALRFCYDGGSYSGLAAQMGQMTPLPTVEETIWEALCTARLVDATKSMDDVDWSRCGRTDAGVSAAGQVVALWIRSRCVDERPLRYKTGEAAIPLTDTSDEELPYVATLNRLLPPTIRIQAWSPVRPTFSARFDCVYRHYKYFFTLGAPSTLVWQPESLSQFSGRLDLDRMRDAAARLVGEHDFRNMCKVDASKQITNFRRRIDGASIDPVCRGWSDRPIPAPDPHSTDEPMYVLNLRGSAFLYHQVRHIMAVLFMVGARLEDPSIVDELLNVHTGAAAADRLHVWQWLESMDSNHVQQPAIIDSADRAGALTESGSTMARVTAGSAAINAHDKNRILSLPMPPDDLPTIETKPAYEMAADRPLMLWECGFHPSHVQWRASTYAGPMSPIPQDDRLIDYSSSVRASSQLHALWTSEAIRTELMRHLVLATATGSGTSLPTCTSFEQARSPLVPQSTSEDSTAPVPARAHLVPLGNGTIRPTTRYKRLAARPRDVSADVKNEKWREGKGRRRAERRQSHTPADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZT5</accession>
    <name>A8PZT5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730949.1">
        <property type="nucleotide sequence ID" value="XM_001730897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZT5"/>
    <dbReference type="STRING" id="425265.A8PZT5"/>
    <dbReference type="GeneID" id="5855256"/>
    <dbReference type="KEGG" id="mgl:MGL_1948"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1948"/>
    <dbReference type="InParanoid" id="A8PZT5"/>
    <dbReference type="OMA" id="HNENHAD"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="411" mass="46365" checksum="0AA417CFFC1FDDB9" modified="2008-01-15" version="1">MAAALTSVAGVTALLDEHDIKLQAYALQKLNTLVDRFWTELADSLTRLEELYEDETFPERHLAALVVSKIYFYLGEFDDALTFALGAEALFDVNQRSEYVETVVSKAIDQYVVQRNTPESPPLSPRFTSIIDKMIARCIESEEYHQVLGIALESRRLDVIEQVFKTTQDKALLSYVLEMVIRVLNVPEVRRQVLQLLVQLFQSLDEPDYFSTAQCYVYLNEPQPVSEMLRSLVRCAAKDEHAALVAYQTAFDLVEGATQEFLHHVRADIEKVSEDAVSKQVMSILSGKESINLYRDFLHNENHADLTILKTTKDALDAHYSAHHSAVSLSNAFMNAGTGSDKFLRENLDWLAKASNWSKFTATSALGVLHRGTIDEGLNLLRPYLPPENGSPCQQRVFGRWQSVCLGPHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZY3</accession>
    <name>A8PZY3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="9">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1961</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730962.1">
        <property type="nucleotide sequence ID" value="XM_001730910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZY3"/>
    <dbReference type="FunCoup" id="A8PZY3">
        <property type="interactions" value="473"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZY3"/>
    <dbReference type="GeneID" id="5855269"/>
    <dbReference type="KEGG" id="mgl:MGL_1961"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1961"/>
    <dbReference type="InParanoid" id="A8PZY3"/>
    <dbReference type="OMA" id="PNCYEFG"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="175" mass="19980" checksum="58399E25B2966B1F" modified="2008-01-15" version="1">MSAHAALKDAGYLVTSCGTGSAVRLPGPSIDKPNIYAFGTPYETMFQDLMKKDSRLYEANGLLPMLDRNRHIKSAPERWQECRRVSDVVITCEERCFDSVCEDLLSRRQELNRPVHVINVEIKDNHEEAQKAANAILSLAEMIEQARDIDEDMDEILEKQQQCFAYPLLHTVAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0K2</accession>
    <name>A8Q0K2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731046.1">
        <property type="nucleotide sequence ID" value="XM_001730994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0K2"/>
    <dbReference type="FunCoup" id="A8Q0K2">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0K2"/>
    <dbReference type="GeneID" id="5855353"/>
    <dbReference type="KEGG" id="mgl:MGL_2045"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2045"/>
    <dbReference type="InParanoid" id="A8Q0K2"/>
    <dbReference type="OMA" id="GGQISKM"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20684" checksum="2FB80BDC499EA109" modified="2008-01-15" version="1">MGSLLSRLKGKLFGTRELRVLMLGLDNAGKTTILYKLKLRQSVKTIPTVGFNVETISYRNIKFNVWDVGGQDSIRPLWRHYYTGTQGLIYVVDSRDRARIDEAREELHRILSDREMRHCVLLVFANKQDLAGAMSPQELTDRLGLQAMQSRPWFVHPSCAMSGQGLSEGLQWLSQNIHDPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0U7</accession>
    <name>A8Q0U7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2084</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731085.1">
        <property type="nucleotide sequence ID" value="XM_001731033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0U7"/>
    <dbReference type="GeneID" id="5855392"/>
    <dbReference type="KEGG" id="mgl:MGL_2084"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2084"/>
    <dbReference type="InParanoid" id="A8Q0U7"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="807"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="61"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="396"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="863" mass="95288" checksum="016E93C49B8A7455" modified="2008-01-15" version="1">MVSTEGQTGADEWNAPFRSPLILPHRSKLPNVLYILSFSEPFKAPYRDLWGCLTHPYTCYAFGIALALASGGGIAAIDILYGYWTQNATSNVDNLAPAMGYNNMLAWVTAVIGAFAFVTNWTFPVLLSYAAHKLCAGLRREYFAATIIQDPTFYDSHGPGAITTFANRDVSQIRSALGEKLGFLLNAVGTVIACIVMAFSRAPTHAGVLLSLLAFSLIALFTLGSLAEKTTAKVMEVDGRLSTYIEQVIASVRVVHSFELVQTLVDRMKNLYIYPLTRAVNFRSIVRGGDMSAMYFTVTVLYPLGFWWASMQVANGRESMNGVVSSFFNYLNTLFSMAMVVTHFQSVVESMAMVANMRATIEREPRIDVRKTSGHILGIPASKETRTEERTYVPSFSLEHVTFAYPGRPYSASLEDVSIEFRPGTVTALVGPSGSGKSTITSLLSREYDPDSAEEAMCNCQFNSSSSKKQRASQQPQDEDEKQLQPVKGTGRVLFGGVDVRTLNVRWMRSQIAVVRQNPQLFTGTIAENVAMGLSAGILSDVSADDPIVRAKVKAALVKAEAMGFVDKLPNGMDTHLSGGRNVHLSGGQRQRIAIARALVREPQVLCLDEATSALDTSTEECIKRSLAKEQTERGMTTIIVAHRLSTIQHADQIVAMKDGRVVERGTHDELLQLKGGLYHKMVMHNRIASGEPDVDEDDQVSEHGSSWRPMQTRKERYVHPEMHEPILHHSHANIMVPEVVSRSGTGAMSSTWDASERRQEIIHEFSEDVNQSCELSANAKDPESPPFRPPAKSKQIHLYELLIGQYWLLLPGIIFALCVAASFPIVAWLSGYVLEGLGNPNLRQMRHDHESMDTVVLYCIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q164</accession>
    <name>A8Q164_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS19m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730742.1">
        <property type="nucleotide sequence ID" value="XM_001730690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q164"/>
    <dbReference type="FunCoup" id="A8Q164">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q164"/>
    <dbReference type="GeneID" id="5855049"/>
    <dbReference type="KEGG" id="mgl:MGL_1741"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1741"/>
    <dbReference type="InParanoid" id="A8Q164"/>
    <dbReference type="OMA" id="YVAFEIT"/>
    <dbReference type="OrthoDB" id="2043at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="87" mass="9903" checksum="17F1AD3CDEC31798" modified="2008-01-15" version="1">MFLSAVRASRSAWKGPFFVPFPNLQQALKNNAPIRTNARSCTILPNFVGLKFLVHNGKFHLPVTITEEMVGHKLGEFAPTRKRFSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1A9</accession>
    <name>A8Q1A9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730761.1">
        <property type="nucleotide sequence ID" value="XM_001730709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1A9"/>
    <dbReference type="FunCoup" id="A8Q1A9">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1A9"/>
    <dbReference type="GeneID" id="5855068"/>
    <dbReference type="KEGG" id="mgl:MGL_1760"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1760"/>
    <dbReference type="InParanoid" id="A8Q1A9"/>
    <dbReference type="OMA" id="KSQQTHK"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="363"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="536" mass="56976" checksum="27104702802F733B" modified="2008-01-15" version="1">MSSGIGNLTTLIKRLEAATSRLEDIAMAQSATTSDGSAAPSSTDAGTATAVTANAPALSSEETATQRSELDAKDAVVIDDVPVVRAWDNEVMSVYQELAEKTHALGPVMGEQVGLVGKALDEVRTLIVAASHCRKPEQGLNTAVVAEYLQPLQTALKSVIEFREAHRGEKTFFNHLSTLSEGISSLGWVAVEPTPGPYISEMKDSAQFYANRVIKDFKGVSETHVDWVRSFMALLDTMKSYVMTHYRTGLSWNPQGQNLSTYMNATSSRSESSPAVPPGSAPPAPAPPAPPAPPAAGMLDSSSSAVPGGGMDAVFSEINQGEGITRSLRKVDKSEMTHKNPGLRENGTACIDDKTRPKPGVKPASLSTKKRGPPRKVLEGNKWTVENFENDSHVVIDGTDLGHTVNIFNCDNSVIEVKGKVNAVSLLSCVKTSVLLDTLVSSLEVTRCTSFAAQVTGYTPTVLIDNTDGGQMYLSEQGLKTDIITAKSSALNVCVPAMSGEPGVIEEIALPEQLKHTLTRSGTRTQARSEVVQHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1N3</accession>
    <name>A8Q1N3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730815.1">
        <property type="nucleotide sequence ID" value="XM_001730763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1N3"/>
    <dbReference type="SMR" id="A8Q1N3"/>
    <dbReference type="FunCoup" id="A8Q1N3">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1N3"/>
    <dbReference type="GeneID" id="5855122"/>
    <dbReference type="KEGG" id="mgl:MGL_1814"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1814"/>
    <dbReference type="InParanoid" id="A8Q1N3"/>
    <dbReference type="OMA" id="WHYIIET"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="241" mass="27031" checksum="3FEA6F89874C6C6F" modified="2008-01-15" version="1">MLPISREVVDSLLDRNASWSKDFITHQPDLACALREGQHPKVFWIGCSDSRVPESVVCNARPGELFVLRNVANQFHLHDDSAVSALTFAVQALGVEHVIVVGHTSCGGVAAAVKQALKEQEDDYEPPPSSALARHLSSLTELARYFRVRVRERNIMSGKSMQERLVPLLTEASVRRQIQNIVEHPVIQDNWNQRVSPLNGKVNPRVTIHGWIHNLHDNRLFDLNVSVPPPPLNEEKKQSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q261</accession>
    <name>A8Q261_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730692.1">
        <property type="nucleotide sequence ID" value="XM_001730640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q261"/>
    <dbReference type="GeneID" id="5854988"/>
    <dbReference type="KEGG" id="mgl:MGL_2146"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2146"/>
    <dbReference type="InParanoid" id="A8Q261"/>
    <dbReference type="OMA" id="QLWAYCP"/>
    <dbReference type="OrthoDB" id="3358293at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="173" mass="18962" checksum="2537B9571ECA4F9A" modified="2008-01-15" version="1">MCDSSVYEYTQSMISVHQPSPSRSIKRKCHYDDDTVTDAPNPSTDGLCPQTAAQRTQSHLPGSDELAEFYPLPPNLNQAVLASVGVGGSKQRDLPMRAWGMWSYRTTPGLLQPPTSSSAVDSYSMDEDMTSISPRHGPHCQSIPQLSVRSFGPTSQLWAYCPDCHAFAKVPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q268</accession>
    <name>A8Q268_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2153</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730699.1">
        <property type="nucleotide sequence ID" value="XM_001730647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q268"/>
    <dbReference type="STRING" id="425265.A8Q268"/>
    <dbReference type="GeneID" id="5855005"/>
    <dbReference type="KEGG" id="mgl:MGL_2153"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2153"/>
    <dbReference type="InParanoid" id="A8Q268"/>
    <dbReference type="OMA" id="DCREWDY"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000013">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="10">
        <location>
            <begin position="240"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="535" mass="60286" checksum="665957074339F4C6" modified="2008-01-15" version="1">MPRLVLIRHGVTEWSKCGKHTGRTDLPLLEEGMAEASQFGDQLVGFSNDAILCPSRIGHILRSPRQRCAQTLECVLGNDKQRQLLGLPDVKVLDDCREWDYGAYEGITTVHIRQSVPEWNIYEHGTPDHETDPNLPGESPQQISERADRVVRCIRAMHQSTRKDVVLFTHGHFSSVLIGRFLGLSMHLSKAVTMGTTGTAILTYTHHTFNEPVLGGLLSPNFDVQSNSVAVRGKVHEEYQYLNLVSSIIRHGEIRADRTGTGTIAQFAPTRTLKFDLSGGKLPLLTTKRVFFRGVLEELLWFIAGCTDAKRLSERDVHIWDGNGSLEFLQRRGLSHRREGDLGPIYGFQWRHFGAKYIDADTDYTGQGVDQLAQVIHQIRHNPADRRILLCAWNPADLDSMALPPCHILCQFFVSMPTTDAMSKGQRPRLKCQMYQRSCDLGLGVPFNIASYSLLTHFIAAVTDCEAAEFTLVMGDAHVYLDHVHPLQEQLRRTPRAFPTVHIRRNVTSIDEIRPDDVQLLNYSPHGKINMQMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q291</accession>
    <name>A8Q291_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_2170</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730716.1">
        <property type="nucleotide sequence ID" value="XM_001730664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q291"/>
    <dbReference type="FunCoup" id="A8Q291">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q291"/>
    <dbReference type="GeneID" id="5855022"/>
    <dbReference type="KEGG" id="mgl:MGL_2170"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2170"/>
    <dbReference type="InParanoid" id="A8Q291"/>
    <dbReference type="OMA" id="TYEDRHT"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="61"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="241"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="451"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP43502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="502" mass="55995" checksum="30D2309A08CB2E91" modified="2008-01-15" version="1">MANTAPGMESQRPQKDTRPQTEDVTATKGNDFEDFFLKRELLMGIFEAGFEHPSPIQEEAIPIALSGRDVLARAKNGTGKTAAYVIPTLERVNTKKNKIQAVLLVPTRELALQTSQVAKTLGKHLGIEIMVSTGGTTLKDDILRLGQTVHILVGTPGRILDLASKGIADLSQCTTYVMDEADKLLSPEFTPVMEQLLGLLPKERQVMLFSATFPLIVKDFKDKHMVKPYEINLMDELTLRGVTQYYAFVEERQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCFYSHAKMLQAHRNRVFHDFRNGACRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRFGHMGLAINLITYEDRFNLYRIEQELGTEVQPIPATIDKRLYVAPSLIQEAENRERDAQEQGKPTQGPSIMQQGLPAIPPTQAAMHAVPVSQNANFTNTVPNRRGGRRNNRRGNGNRNPNSRIHNQSTAGNEGHSEGAAPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q299</accession>
    <name>A8Q299_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="2">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730721.1">
        <property type="nucleotide sequence ID" value="XM_001730669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q299"/>
    <dbReference type="STRING" id="425265.A8Q299"/>
    <dbReference type="GeneID" id="5855027"/>
    <dbReference type="KEGG" id="mgl:MGL_2175"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2175"/>
    <dbReference type="InParanoid" id="A8Q299"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="5">
        <location>
            <begin position="28"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="446"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="479" mass="54358" checksum="FB2C4D5315CA4BBB" modified="2008-01-15" version="1">MLEISLDMTPTPEPPTSLVPATPRFVDSMLSWATDLLRNVDALCTEAATLRESIALIQQSVVVALANVQLHANNIKSATTELVRIAQKDFERMEQLLHQYTADLDILRRVPVHPQLVRRSASGGTASVLCDVVDVAHVHRVAASCRSAREDVRALYERVMETESRLTRDLRDLTHEIEQTDVKPSIETYEQIVGLQEQVHVEHASLVSMCQRVESPSNPDWLHAQAKAEALYARETPILHTLDCLVQDRNELLYRDINLMQDISGLQSDFTELSALVAHTDVTLESSLNDGFQVLEHVHSMYGAYGALLAEAVRRSEFKRMYLAKAQCIAELMAKLSEKETKRRKRLWQDLNGAWPWELPCMDLSLPVFDITTRCHDSSSSTTYTQEDLAEFHAQLHALDREMRTIDSTRSVEHDVHIYMRRFASEPHNFEEDFCVLARRELGLEDMAESSEDEAIDSVDGNVDDDDDTTHKQSRPERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2R6</accession>
    <name>A8Q2R6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730429.1">
        <property type="nucleotide sequence ID" value="XM_001730377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2R6"/>
    <dbReference type="FunCoup" id="A8Q2R6">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2R6"/>
    <dbReference type="GeneID" id="5854736"/>
    <dbReference type="KEGG" id="mgl:MGL_2225"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2225"/>
    <dbReference type="InParanoid" id="A8Q2R6"/>
    <dbReference type="OMA" id="MCWDIRT"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="344" mass="37818" checksum="A838DC27A7E9BE6C" modified="2008-01-15" version="1">MALYPSADQLDKSATALSRNTDLTPKHTIQAHAGAVHVARYNPGGRYLLTGGGDQQIHLWNAKTGVSDEVDSKGRSPCIQRYSAHSYEVLCLDIAPDSMRFASAGPDRAVMLWDVATGQVFRRFHSHTGRIHDVRFAGAHDDGSLLYTGGSDKTLRAFDLRASNAWRPIWEASDAQDAILALAPTPNCVHTASVDGALRTYDVRMGQLRTDTLDEPITSLTPTKDGAAVLVTQLSSTHRLMDLADGTQLQCFQGHTQNAFRCHSDLSRDEAVVFSGDETGHLYAWDTLKGRVKWAHKPDMRGSLRHRRAPHVPVTILWTETCPDEQDPQVVTASSCGTVHVWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2S1</accession>
    <name>A8Q2S1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730431.1">
        <property type="nucleotide sequence ID" value="XM_001730379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2S1"/>
    <dbReference type="GeneID" id="5854738"/>
    <dbReference type="KEGG" id="mgl:MGL_2227"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2227"/>
    <dbReference type="InParanoid" id="A8Q2S1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10726" checksum="5F31DAED9FFE8D60" modified="2008-01-15" version="1">MMSKACRRFAVIGAGPAGLAAAQQLRAVAGNAPVDIVVFERQSTIGGLWTYEPDPGPCILRVPAFPRPGDAGYASSNPHELQCPRAMYEDLRTNIPSVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2X3</accession>
    <name>A8Q2X3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_2262</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730466.1">
        <property type="nucleotide sequence ID" value="XM_001730414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2X3"/>
    <dbReference type="FunCoup" id="A8Q2X3">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2X3"/>
    <dbReference type="GeneID" id="5854773"/>
    <dbReference type="KEGG" id="mgl:MGL_2262"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2262"/>
    <dbReference type="InParanoid" id="A8Q2X3"/>
    <dbReference type="OMA" id="KVEPWSN"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="333"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="736"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="821"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP43252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1014" mass="114316" checksum="6FF362FBE89CC67D" modified="2008-01-15" version="1">MSPDTATDDLDAPLFFSEPVPESENIVPQKRVRSEREADVHAWKRRYMGTFVLCGYSMTKGYGHVRAGERVLIQRKSKNHSTSSSKTQHRSREKTDYIVRFSTTRGFEVGRIPVDVASWMSRLLDDQLVEFDGCIVDTPAKLEVGSDILLQVKAYICYTAFTTSVSGHCHLDDALEWSKTSDAKESTQERLLRHRKVAWQRLFRACHLVPKRGNTSLHTASIPSWHTTHDADDDGTEITSECIQDMYTRSEKSHTDLPVVDPPATFALELRSYQKQALGWMQSMEDTYYSSRQNTELHPLWEEYEFPLADDVDCGHGPFYMNPYIGELSLVFQPASRAARGGILADEMGLGKTIMLASLIHANRSMDLDRPPTSMSSSRSRSTHLRQASLHFGKAPRLQRTAATLVVAPMSLLSQWRTELDRASQPGTLSIALYYGDAREQLAQQLAKGEVDVVVTSYGTLTAEYKHLDKRGTSTLFSGTWHRVILDEAHTIKNRSTLAARAACRLEADRRWALTGTPIQNRLTDLYSLLRFLRVEPWGDIRFFNSFLAKPFASQNAKALDIVQAILSSLLLRREKHTPGPDGRPIVDIPPKTWDTQHLTFSATERDIYLSVYDRARTQYRELAAQGLVGKNVSLIFAVLMRLRQAVCHPYLVLQKHNQAPEEQTYEERLRELVKRYEAEGNAGSTYARDVLGSLLAAAEVRDEASLQTNAGDNEVFENSHHERIGDNDTDEEEECPFCMELKASKCFLPRCMHHGCRDCLVQYLQACEDRGEEPHCPVCRQGPVQVEDLVESVRPTIETSSTAASAPAGPARGSTKLNALMQQLAELTKSDPTCKGVIFSQFTGFLNLIQAHLVQRQYAFVRLDGRTPQKEREHVLRTFANEPGPFFLLMSLRAGGVGLNCTFLCACTNTSSDSGESRVAHGLLVESKHVCCKKHETKKTRLTPVREDQAIDRVHRLGQSRAVTVHRLLVNDTIEDRILEIQRHKKQLVDHALSIKPYSADSDTLENLRLLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q305</accession>
    <name>A8Q305_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730487.1">
        <property type="nucleotide sequence ID" value="XM_001730435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q305"/>
    <dbReference type="FunCoup" id="A8Q305">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q305"/>
    <dbReference type="GeneID" id="5854794"/>
    <dbReference type="KEGG" id="mgl:MGL_2283"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2283"/>
    <dbReference type="InParanoid" id="A8Q305"/>
    <dbReference type="OMA" id="VVEFPLH"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728052" description="EXS domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="129"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="376" mass="43073" checksum="ED72E249BE0297D0" modified="2008-01-15" version="1">MAANSGAMALYLLALCHVAWATFCWLMYRFHVDASTGARTMYSQAWEVATLAGLLALWMIPGPFRHMLRTWNRTLVRLLTPSLHVSVSFTDVVAADILTSFAKVLGDVWISLVVLTCFLLGRRADDSVLLRAEMSIAVPMLISVPYLIRLRQCLCEYVVSSQRPRRPLYNALKYLSSLPVIWLRVTPTLLHASPALSRMFNWIWYVCVLVNTLFSFWWDVTNDWGLDLLQIHSFRAMVAEPRAHLPVLHRRSSVIDTDLTSSAPPSIDFRSPVSGDPTGDTGTGGNAFVRRHTRRASLLRRPEKPLPLPTTVYWVFLVVNLFLRFTWSLKLSSHWQFLVEWQRGLLLLEALEIVRRSVWVLLRVEWELVRQSPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q337</accession>
    <name>A8Q337_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730507.1">
        <property type="nucleotide sequence ID" value="XM_001730455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q337"/>
    <dbReference type="STRING" id="425265.A8Q337"/>
    <dbReference type="GeneID" id="5854814"/>
    <dbReference type="KEGG" id="mgl:MGL_2303"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2303"/>
    <dbReference type="InParanoid" id="A8Q337"/>
    <dbReference type="OMA" id="HRGWKDL"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="68745" checksum="5C0C1CB583A36DB1" modified="2008-01-15" version="1">MARMSERGRLWAKRGLRVAAVATGIVGGLYMLAQFALAKFNDMQERLLRDRVARENLRRRFLQNQEDCNFTIMALLPTLSAQIFAEMDVESISHALREQNKKSIHPPRTTPSAAYETRNVSESHSQPVSTSEMSETPTAETTTPPVSAAASSLSPLDAQKGPAEGPVSNEDAAATVAVSATKSMPESLSQSATPQFSTPQCLTPQLEAPNAVAMAGENADADANTNVIEHAETSKMVGDSPPADHATPKKMCPQSGLDLVSEKPPEPISATTRLPAITKHDVVADSETPATSVTPSVDTGPSSVSEDERRATKLRLWNEIKLKSFERTFTTLYTLVFLSLQTYIQLNLLGRRAYLTALENQAKRDAYARAQRDLGAVDESHFIELHGDGSDTVMRDDMFGVDERLSQDTEKKYLTSSYWFLHYGWREVAADVRQAVQDELADMPLKTMLTYGHFEALVDRIRERVEKPSSFDTHSHGFWGRPTGFSGILLPESEREEARMLRDAGALDPAASLDEAVTPALRALLDETKDYIDSPDFAHVVSSACEQVFSLFLSHMATSFGVRVNEARRIDKPLLLAKVLPLVSQQAQVALNATPNDYVDAVVDCRDLRALSVLMYAAWDDEGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3F5</accession>
    <name>A8Q3F5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730587.1">
        <property type="nucleotide sequence ID" value="XM_001730535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3F5"/>
    <dbReference type="GeneID" id="5854894"/>
    <dbReference type="KEGG" id="mgl:MGL_2383"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2383"/>
    <dbReference type="InParanoid" id="A8Q3F5"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="448" mass="50113" checksum="5864D8EC430AEC42" modified="2008-01-15" version="1">MSLIRRVYHPEGIGETAQTMVRRPDPDPSTSEGNGSATALFQANDQKHTRVAKEVEGDVPPIMDEGSLSALESCPQRNLPQTCFANTEDDFEEYNLHAITNEPDVTTILHQSRIEHTSWCFADSDSIPAMISSPGSEIQQTMSLLKAEEYERQILCCQFCTSGVGLAESLGLSPNLVGQAPPSPPPGTPSDEMSVHEVRSSEEQLYTVGQYERVTTPSPSPPLCRDSLQALRLLSSQSILDVDVPIETSERTAFTTPSFDIINEWRKAFGAFKRYTPPLTPQHTPPHLRPQHEEPPHNSPQVSLYEMPYHSQRHSFQQSPLIKEATGESEPAGPDPFDDLGAKNHATPWHKARSHRAWCPWGRTRSKSSPCERQPISSYPEIHTCEPLSMTWSRHHAQAAMRHATTPEQAPRRVRRQVSTAMFSRTWRTFLDRARGRYSTSDAISNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3K2</accession>
    <name>A8Q3K2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730633.1">
        <property type="nucleotide sequence ID" value="XM_001730581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3K2"/>
    <dbReference type="STRING" id="425265.A8Q3K2"/>
    <dbReference type="GeneID" id="5854940"/>
    <dbReference type="KEGG" id="mgl:MGL_2429"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2429"/>
    <dbReference type="InParanoid" id="A8Q3K2"/>
    <dbReference type="OMA" id="SINHEAK"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21062" checksum="03BCEFFAC5E4B839" modified="2008-01-15" version="1">MGHGSNDKLFITPSEYSGQHGQHGATSGARREMSVVVPFHMCAITHQPWTTPACLVQDGLICEKAHLVAFIEQHHQSPATGEKASIDDILILHISQNERQMSQDPVSMREFTDHSHLVAIRTSGHVYLYDTVFQLNVRTKNMRDLVTDVPFTKSDILTLQDPHDPGRRTMQNMYHVQHHLTPKYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q467</accession>
    <name>A8Q467_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730122.1">
        <property type="nucleotide sequence ID" value="XM_001730070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q467"/>
    <dbReference type="FunCoup" id="A8Q467">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q467"/>
    <dbReference type="GeneID" id="5854429"/>
    <dbReference type="KEGG" id="mgl:MGL_2504"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2504"/>
    <dbReference type="InParanoid" id="A8Q467"/>
    <dbReference type="OMA" id="CAKAVEY"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PNO1 second type I KH" evidence="8">
        <location>
            <begin position="211"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="301" mass="33647" checksum="58EFEF7731FB1CB6" modified="2008-01-15" version="1">MKQERANASAKALKRSEKRSASNPKPLSQEKHELPVRKPFGQEDSDDDDHDDEDMLASGHRDTGDQDEDDQLIIDQDMVEQPDHHEASGQDVDMDEDALRFQPISASALAASQAGADNRAYSQVRKVPIPPHRMSPLKRDWPKIYTPLVEQAGLMVRMNVRTRAVEIKSSKYTEDLGVIQKACDFVKAYALGFDADDALALLRLDDLYVDSFEMKDVKTLHGDHLSRAIGRIAGKDGRTRFAIENASRTRIVLADTKIHILGAYQNIRMAKDSIVALIMGSPPGKVYAKLRTVSARMRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4B6</accession>
    <name>A8Q4B6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730138.1">
        <property type="nucleotide sequence ID" value="XM_001730086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4B6"/>
    <dbReference type="FunCoup" id="A8Q4B6">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="5854445"/>
    <dbReference type="KEGG" id="mgl:MGL_2520"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2520"/>
    <dbReference type="InParanoid" id="A8Q4B6"/>
    <dbReference type="OMA" id="WCFYVVS"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="251"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="694" mass="77432" checksum="5ED4418238303926" modified="2008-01-15" version="1">MDEQVTKEKPESSAVEDPLADHAILSQPIVSSSTNEYSPEVEQRAGSPVAESVAVASEDGESLPDITKIQNKPKESRSSFRHQRRAERTWSTSAPSGLVHYLRRTSMAAPPLADALNAHTAVEAPKMTLKADSSNENIFKRAFSEIYEKLERYESQDAEEGARFEYRLARARQALPDNVQSIEDIRGQDMEDIEEGKIQPLSMRRSSTTRSEPKEKGDAEQKPDPFLVTFETTNSEHENPRTWSFGYRVSILAMYAMFSLIGPFASSVVSPASAAIAEDLDMESKLEQNLLVGLFMLAFVVGPLCSAPVSETYGRRVVVLVCSLFFIVFNIGCAVANTAAQLLVLRFFSGAFGGAIIPMGGGTVSDMFEVHERGTAMALYTIAPVLGPSLAPIISGWIIQGWGKDHWRWVFWVSTILAGFICVLGIFFVRETYAPRLLYLKARKLRRESGDKRYHSSFEMRSETIWQKVKRILLRPLIFLATEPLVTLPALYMSIVYACFYLNVASLPYVFRDHYEYNVGIASLHYIGLMIGLVGFGQFGGWFIDFMYKRLSRKHGRRRPEYKLPLLMITVYVLPAGMLLFGWTADYHKFWIAPDIGLVLVGSGIIGSMLLIQMYLADLMTIYAASAISAVTSSRSLMAFVFLLFSNAMLTNLGVGWTMSVLALIVAVVGIPAPFLLYRYGPFLRSKSKYCVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4U1</accession>
    <name>A8Q4U1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2638</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730256.1">
        <property type="nucleotide sequence ID" value="XM_001730204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4U1"/>
    <dbReference type="FunCoup" id="A8Q4U1">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4U1"/>
    <dbReference type="GeneID" id="5854561"/>
    <dbReference type="KEGG" id="mgl:MGL_2638"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2638"/>
    <dbReference type="InParanoid" id="A8Q4U1"/>
    <dbReference type="OMA" id="HARMRYS"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="526"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="714" mass="78051" checksum="BE8B422C3596CCEF" modified="2008-01-15" version="1">MSRPEEGTPASQDGRDGSSLGLPSSSPGRLSSHGRRFASRSPSVVWDDASPLQFPTSSPAASLGSQHTPTPRRPHASLSSFSGSGDYREPLFFPPSTSSTPRHSRRGDIHSSSHSFVSSPSVLARRMHSRPPASSSSGPASGAGAGHSSEAASEDLVFSHATSDDQHGAGHPPNHMLKVIWGTSVSVGETMQLFQTFLRGFRLKYRWAYARTHGLPHARLPNADGELLLYEDYMRQMRQTHQTNLNLRIRDLAAFPPSKKLALQLVRYPQEVVPIMDTVLKDQMLILAEEDLRSSVSSYEVEMLREQMDLIESLLYKVRPYGGTSTNMRDLNPSDIDKLTTVEIDRGRIMEPQRCPRDMCNQLGSLSLIHNRCEFADRQVVRLQETPDVVPDGQTPHSLSLCVYDELVDVCKPGDRVEVTGIFRSVPVRVSPRQRTLKSLFKTYVDVVHVRLNSTRRVDLDLTTRDAMQAQSIGIGGDEEGELFDAHGLRSGDAPSAPPPASGRMALMPSEEMQDQIQRLAERPDVYEMLAHSLAPSIYEMEDMKKGVLLQLFGGTNKSITTGGGLGGPRYRGDINVLIVGDPGTSKSQMLQYVHKIAPRGMYVSGKGSSAVGLTAYVTRDPETRQLVLESGALVLSDGGVCCIDEFDKMSDATRSVLHEVMEQQTVSVAKAGIITTLNARTSVLAAANPIGSKYDIHMPITKNIDCADAAEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q521</accession>
    <name>A8Q521_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730319.1">
        <property type="nucleotide sequence ID" value="XM_001730267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q521"/>
    <dbReference type="FunCoup" id="A8Q521">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="GeneID" id="5854624"/>
    <dbReference type="KEGG" id="mgl:MGL_2701"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2701"/>
    <dbReference type="InParanoid" id="A8Q521"/>
    <dbReference type="OMA" id="GAVHLHQ"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="237"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="431"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1004" mass="112923" checksum="16F6F48E782F7E34" modified="2008-01-15" version="1">MTHKQVVPTVDMLQASVRSMTARSLDVQDLARIKALCPDMVHLAYVPTAALRTERAGKRRRTRMDDRDDMYTPPARDENTHTLLFEFLDRDLATDKATSRRYVRSSKPSQEATVQLVSRRNATFTRAVQELLSACETTQEDPIELLKEASIAAVPKPPEETPSISSALTRSSIAEILARLPDMPWWREQIVPGGRRTFPAREPKFGFVEPPLDSDIRDALAAAHGIQQLYTHQALALTLFQHGRHVVVSTGTSSGKSLVYQIPIMHVLATIPSATAMCIFPTKALTQDQLGSLRRLLHHHPSTLGVAVDAYDGDTPADYRRSIREQAGVLFTNPDMLHQAILPHEDRWRRFLQGLRVVVLDELHVYTGTFGTHVALILRRLRRLCAAMGNHSIQFVSCSATIASPTEHMSLLLGIDTQQIELIADDGAPCGKKEWIVWNPPLIDVEEPGQGRVSSYKEVSQLFRHLIREDFLHEGHTHLADRVHAYRSGYAPSDRRKLEHDMAHGHVLGLIATSALELGIDIGVLDAVILFGMPYTSASMWQQAGRAGRRQKDALVVLLGEPFPVDQYYMRHPELVFAPPLINLWVDPSNELLLEAHVQCAAYEMPWSSEDTKYFGERALSIVQRLCVRDQDGFYHLGKSDLISPATNIPIRGARQETYRYVDATSAQLLEEVEVERVYFEAYEGAVFLHQGATYVCQSVHHDARLVLLVRSHVLYHTRPRDLVDVDACETWRMRTLSHSSARACYGRVDIIFRVWGYFKVDRRANILDVVDIETAPLIRHTHGVWLDVPWKIVEALTSHEILASAAIHATEHAVLSLTPLFVASAADDVRTECKVPMRELSGRPTQRKRPSRLIFYDKPGQNAGICTQVFEHLDALLCIALHVLETCECSDGCPRCIETPHCLHENQVSSKRGAMAVLRGLLHRPMFDVWDRCNEVSATKDKNVLLHTLCAPNPVPQRDDARLEHIIEDPAPSHDMILLNVQNSAATKGRPYEQCSSLFFNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q581</accession>
    <name>A8Q581_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730365.1">
        <property type="nucleotide sequence ID" value="XM_001730313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q581"/>
    <dbReference type="STRING" id="425265.A8Q581"/>
    <dbReference type="GeneID" id="5854670"/>
    <dbReference type="KEGG" id="mgl:MGL_2747"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2747"/>
    <dbReference type="InParanoid" id="A8Q581"/>
    <dbReference type="OMA" id="NITHEVR"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="133"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="317" mass="35540" checksum="68D71D6ECC336444" modified="2008-01-15" version="1">MPRLLYVTPERIVKSKTLLATLQRVYEAGRLERIVVDEAHCCSMMGHDYRPDYHKLSICRRLFPETPMMGLTATLSAQALCDVLQILGMRDSTTQPTEALPRRTVYFRAPLSRPNLKYSVRMRPTNALATQQMVTSYILQHHAEHSGIVYCLSRKDTHTMSEALTQLSHGQILTGVYHSDLDEVEKHRVHTMWRTGEIKVVCATIAFGMGIDKGDVRFVVHACISKSLEGYYQETGRAGRDGLPADCVLLYRPGDLSRLSAMTASEVGALDKCTYIVLRFSYSGTCMLTSTLRYDSTCHAILCTVSELPSVRAGRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5J6</accession>
    <name>A8Q5J6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729800.1">
        <property type="nucleotide sequence ID" value="XM_001729748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5J6"/>
    <dbReference type="STRING" id="425265.A8Q5J6"/>
    <dbReference type="GeneID" id="5854101"/>
    <dbReference type="KEGG" id="mgl:MGL_2786"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2786"/>
    <dbReference type="InParanoid" id="A8Q5J6"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000252">
        <property type="entry name" value="Related to calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="815"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="873"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="889"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="899" mass="102283" checksum="67922CCA9403A625" modified="2008-01-15" version="1">MTNYVLGHGTFAVVRVCEENETGVQRAVKIVARRPLQSDHDGNEMDVRPGRIARDEIEIMMRVQHPNVIRLWDFYETDEGMFLVMDLCPGGELFDNIVKRTTFKEYDAQCIMRQLLLGVEYLHSNGIVHRDLKPENILMYDEDDIYKGIVISDFGLAKLMPEEGLLLTACGSPQYVAPEVLLGQGYDENVDVWSCGVIAYALLCGYTPFNSESVQHMFQNIVQIEYEFHPAFWPTQSMLAKDFIDRCLCEKNQRMTVHDALQHPWMTHFLQLSPGKEESPILRRVSPAEYHNPLSRCESLTSQLNDLAVLQRLRKRYFTVSDHELVCVEKFVKRFKAQLEMKKDTAPIRTSLNSGTWCVTTESLNKKDCQNAERSKSIPVNDGNFTRHYIRESSDQAQQVAHTTNTIQVLNKLLEQYRTAKLPAYSRVDPKAEMRPQEGMSISKAIRTVPAILNRSYSIGSAIVSHLMYGPPKKSWGVEMSILTRMIREIAEENTDLASISGLQQLFELMRFFPIPDDGLVTPVTFRVKRRNLKGFLSGSDSKETGKRELTGEWIVGKQTWRRLQNEWQTGNRRRSERVILYVHGGAYFVMSATTHRPLTIAISKYCECRVFCVNYRLAPDTIFPGALLDVANAYFRLTDDLHIPPNNVVVAADSAGGGLALALMMYLRDNQYPLPCGAILMSPWVDLTLSCDSWETNKDFDYLPRPGRGNHMNPINAYLGPNIDMYLMHPYVSPLFGEMNGLPPMLIQTGDAERLRDENVLFAHKCALAGVPIRNEIYEDCVHVFQFFLFLEASRKAFQSMRHFMRTVLDKRPKRQASVVEEDTREQLDQEMTGAGAEQLIVPGSPQASQRPAEDCEPDGSHHQTLEGLGPEGDEDTETWELDGEEDAQAKDQLHSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q663</accession>
    <name>A8Q663_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729874.1">
        <property type="nucleotide sequence ID" value="XM_001729822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q663"/>
    <dbReference type="FunCoup" id="A8Q663">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q663"/>
    <dbReference type="GeneID" id="5854181"/>
    <dbReference type="KEGG" id="mgl:MGL_2860"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2860"/>
    <dbReference type="InParanoid" id="A8Q663"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="270" mass="30405" checksum="F91653101C7640DD" modified="2008-01-15" version="1">MGELSSSCLGQIRAVLFDMDGLLIDSERIYTEVVNEILKPFGRQQTWDIKAKLMGKPERDATLVLLSSLWPPNQEDPEDVKRGFGSDCPFAIDEFLRKRNELLLPAFRNVQPMPGAVRLIQHLSKHNIPICVATGSRRHNFEIKSGANPNLFEPFNNRVVCGDDEMIGRGKPYPDIFLNAVKHGLGWQFSDEGRAILEKIRDPGAEFDGKLGGVEGEILVFEDALVRECNGKLTLSFARHHTNHDHSARGPSWSLGWHEGCEPWRIKARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q683</accession>
    <name>A8Q683_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2879</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729893.1">
        <property type="nucleotide sequence ID" value="XM_001729841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q683"/>
    <dbReference type="STRING" id="425265.A8Q683"/>
    <dbReference type="GeneID" id="5854200"/>
    <dbReference type="KEGG" id="mgl:MGL_2879"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2879"/>
    <dbReference type="InParanoid" id="A8Q683"/>
    <dbReference type="OMA" id="HQCEFEG"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="590"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="620"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="483"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="671"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="708" mass="74267" checksum="F73D46B5844EDB24" modified="2008-01-15" version="1">MTSTSGSVNNPPHMSKLATSESSTYGTGSPHGSPRLVMAHHLPSVLSPYRDSSSRFQSIGSPRTSSPRISVLTREASFGSLHYPASSSRPASPSTSHMPERSYSPSPSSGAQSAAARMSTRPLPPRRLSDTSRLVSSALSQGASGCAGLSHPAGASDITMFDDAPGSPRPPLSPGILPPHLSGQTNTGLASAPLPRSPYDTYAANSPSRYGELYAPSPKRDVFRFNAAPAGAPGWRSSSSASLATGRGDGSPWYENRNSPFASSSVRAGSSGLGSRPGSVSGDEDAHSYRMSNDVLPPEDEAATSVRPSPAYTPYGRTPASAAAAATTAGMPVRSDSSGYSSPMYRASALPNAPSPYLANSTPTVAYPPRGMAYRAAEWQGDMYADHAADSYGLRSRPKYENDVYAADTPPAGSYPDTYYNPPYPRGTPNSMPYKYSSAAASVTRSDVDMSSADERSGDDEKMMHTPRRYVAKPSALASSATASATGLGLGPGPVQPAPGSGSAVHRFVTGHGLGSVPATSTATLPSGSGPAPSSSPAVLGPTASAMTSGLPESDSGGPKLHVCDACNKTFSRRSDLARHRRIHTGERPYPCEFPGCGKSFIQRSALTVHSRVHSGERPHQCEFEGCGKSFSDSSSLARHRRTHTGRRPYVCTVPSCGKMFTRRTTLNRHVRSHQMPLKKGTADAAFIDDAPESEEEDDDDDSSDDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6F6</accession>
    <name>A8Q6F6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729966.1">
        <property type="nucleotide sequence ID" value="XM_001729914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6F6"/>
    <dbReference type="FunCoup" id="A8Q6F6">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6F6"/>
    <dbReference type="GeneID" id="5854273"/>
    <dbReference type="KEGG" id="mgl:MGL_2952"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2952"/>
    <dbReference type="InParanoid" id="A8Q6F6"/>
    <dbReference type="OMA" id="TFLMKLT"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13153" checksum="8005C698F120C0D4" modified="2008-01-15" version="1">MKLVRFLMKLNNESVTIELKNGTVIHGTVTGVDVQMNTHLKAVKMTVRGGEPISLDTLSIRGNNTRYWILPDALPLDTLLVDDAPRPKGKRKDEALRGRADRGRGGRGRGGRGRGGRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6G7</accession>
    <name>A8Q6G7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729975.1">
        <property type="nucleotide sequence ID" value="XM_001729923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6G7"/>
    <dbReference type="FunCoup" id="A8Q6G7">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6G7"/>
    <dbReference type="GeneID" id="5854282"/>
    <dbReference type="KEGG" id="mgl:MGL_2961"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2961"/>
    <dbReference type="InParanoid" id="A8Q6G7"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="84" mass="9574" checksum="9512874F9479D9A0" modified="2008-01-15" version="1">MTDVSTGIHEPFDLIRLSLSERVLVKLRGDREMRGILHAYDGHMNLILGDVEETIYDMQVSEDTGAESIQVCLFFLLVWDSNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6M6</accession>
    <name>A8Q6M6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730024.1">
        <property type="nucleotide sequence ID" value="XM_001729972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6M6"/>
    <dbReference type="GeneID" id="5854331"/>
    <dbReference type="KEGG" id="mgl:MGL_3010"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3010"/>
    <dbReference type="InParanoid" id="A8Q6M6"/>
    <dbReference type="OMA" id="HRYGMPG"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="402"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="693" mass="77435" checksum="00484A048CF3E5D9" modified="2008-01-15" version="1">MGNSGPGVLLPSLYGYFSNEPAPTQLRPAGVAYGPHGHGRVGVPWQDDTSLGATSSDGRGYVHPRLSERILASGPSVTNLHPSTSTVHMSPGSELRVQTSQLRNVHVRPGSMLFPAGITSSLCTAEKAKDAHMSRKFEENAALSFSWVIEDVALLNDEVKHGSNATSGGKKSEAWKLQPLFGEERWRLELVRRHKAQTPNTATPTKSRAAHAISRPYVLCLYLSYLGLMSMPIKAELPAHVMIGIRPAQRVHKLPRALDSGFLWRDFFSFTFQQDNDTVVFDRLPDLADVLADPDVAESNAMDLVIQVATGPSVLPESDVRDSEGQSRMRLPFEAPDTVNVPRGLLHALSALVDDGSSGDIMITVLEKGFEQQPTEELAESVGLKTFIQPWPTGTPLPELESDLYPAVFVRDRVLWAHSSILRERSEFFATMIESNFAEGALHETPPNGGRGRTRDAWRRPYRMLRIPGADFVTMYWFLRYLYTEEVELLREEDVQGVALDDYWILNQSQSSAWPDWKWRRIEHSDEWDDDIFPPMNEAAPPLLSEGHIPRSADDSTSATPRGDLRSRTSDKWPNMSDPHPHPPMLPVPPASALSLYRLSHRYGFQQLCDLTMTHVLSLLTPHNAIHYLLCTALLPEIQKAIQEYIVQNWNDVSSSPEFEYCCDQVSTGEWGPLAGRALLSLMRQLRHTSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6P7</accession>
    <name>A8Q6P7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730041.1">
        <property type="nucleotide sequence ID" value="XM_001729989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6P7"/>
    <dbReference type="FunCoup" id="A8Q6P7">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6P7"/>
    <dbReference type="GeneID" id="5854348"/>
    <dbReference type="KEGG" id="mgl:MGL_3027"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3027"/>
    <dbReference type="InParanoid" id="A8Q6P7"/>
    <dbReference type="OMA" id="RMILPAQ"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="535" mass="59879" checksum="2666AD1B9A1DA83F" modified="2008-01-15" version="1">MDPAEAAQRQADLRRMRELMFRAEQKARRANKIKSKTYRRIHRRERERLQQQQREEAKGAADQDSDGDLDEEERFQAAKERARERATLRHKNTGKWAKFHASRHDDASTDARLAVEEQLRRGDELRKRIHAAGDDDDESIGSMDSTNEQEAVAFDELETFARREAEQDARDEAELEASGKKGKSVFHMKFMKDASDRQKRATQETIESLRNEFAHAAADHDDDHDVNEDAWTDSNRDAMGAASTGRAMYGKGFATKTVQAPLAHVPARPTNPFHTGGSNPWLQSNASMAGGGHSAGASRQTPQVLIGKDSRAASRSVHRTERHASRGSDSRALAADDATLDIDPTAQLETATSEEEDDPEPVEVTRHASRGKRGRGQRHVSMQRDLVAEAFAGDDVALDFAKEKRAAIKADAPREEDTTLPGWGSWGGKGVRRKPKNPALIKKIGGLDPAKRKDFGMDNVIVNERLDKKAAKYKAQDLPFPYTSAAQYEAAMRTPIGAEWNTRTQHQRMTMPRVTTKMGQRIDPIRTYDRGMGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q735</accession>
    <name>A8Q735_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729756.1">
        <property type="nucleotide sequence ID" value="XM_001729704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q735"/>
    <dbReference type="FunCoup" id="A8Q735">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q735"/>
    <dbReference type="GeneID" id="5854062"/>
    <dbReference type="KEGG" id="mgl:MGL_3300"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3300"/>
    <dbReference type="InParanoid" id="A8Q735"/>
    <dbReference type="OMA" id="NEVLWFM"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546:SF4">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="310" mass="34383" checksum="59A0F73D050566F7" modified="2008-01-15" version="1">MHRRIVALGDIHGDYEHATSILRAAGILHAENDSWAGGSTIFVSTGDTVDRGDDTIRLYRLFQDLREQSRRVGGNVINVLGNHEMMNAMMDWRYVTPGDMASFGGPVGRRQAMSLHGWLGMEWMQHYNVTMNVPLLPDPVAVYFPTQRASFVHGGITPAFAQIGVDAMNKDAHSLLTKALSAYEGDSINITKSEEALWLSDGPFWYRGYALDPHQHACATANRAIDALGVSSLIMGHTPHMSGIHARCAHGQIFIIDTGMSRAYGGRLSALEIDSYAEKRGWFTWCMTSTYSAVYVPEGRQVLHRIQRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7U8</accession>
    <name>A8Q7U8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Squalene/phytoene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729584.1">
        <property type="nucleotide sequence ID" value="XM_001729532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7U8"/>
    <dbReference type="STRING" id="425265.A8Q7U8"/>
    <dbReference type="GeneID" id="5853890"/>
    <dbReference type="KEGG" id="mgl:MGL_3128"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3128"/>
    <dbReference type="InParanoid" id="A8Q7U8"/>
    <dbReference type="OMA" id="YSTIMYA"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40398" checksum="9E2D5239FE88D9FC" modified="2008-01-15" version="1">MWQHLSPRTTVCTGSRTGSFALNAPRVHVARAQHTQAYTSALVDTVRQRDYAAYLTHVAYARRVQPHFWALRAFQVELATIKDTVSNELVGRIRMQWWRDAIESIYAGRPPKHPIAQGLYEAISDPAVMAHGSLVKDHFLRIIDAREADLADPLSPPTLEELEKYAEATSSRMLYLLLNLQGLSEPTVDVLFSHLGKAIGLTIFVASLPYHTHPAPRPASAAAASSPHSSVGAAIGGTTRYAPQAGGVPRTPTLPLPLEYILEAGVTQEDVFRHGPGARGLKDAVFYTATRANDYLITARRVIREELGGRVPALATGPMLLAVQPRQFLRKLERVDFNPYDPTLAKRDWLLPWHMWIAARRQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q838</accession>
    <name>A8Q838_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_3195</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729651.1">
        <property type="nucleotide sequence ID" value="XM_001729599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q838"/>
    <dbReference type="MEROPS" id="A01.018"/>
    <dbReference type="GeneID" id="5853957"/>
    <dbReference type="KEGG" id="mgl:MGL_3195"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3195"/>
    <dbReference type="InParanoid" id="A8Q838"/>
    <dbReference type="OMA" id="KYDHDAS"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05488">
        <property type="entry name" value="Proteinase_A_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033819">
        <property type="entry name" value="Saccharopepsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725171" description="Peptidase A1 domain-containing protein" evidence="13">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="106"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="419" mass="46086" checksum="A70620C7077B7F7D" modified="2008-01-15" version="1">MMKVFVSLSLLLAASVALVDAGVFKTKLSKMPYAKERTLASIISQAEFLGFKYGVNNKQQPFSLYQDASGDLRVQSADAGMVSEQWHARAKAGHNVPLTDFLNAQYFADIELGSPPQSFKVILDTGSANLWVPSESCTSIACLLHKKYDNSLSKTYQANGSEFQIHYGSGSMEGFVSRDTLRIGDLDVKDQDFAEAIKEPGLAFAFGKFDGILGLAYDTISVNKIVPPFYRMKEQNLLDQNQFGFYLGSSESEGGEATFGGVDPSRFEGPIVYAPVRRRGYWEVALNKIGFGNEELVLTRTGAAIDTGTSLIAMPTDVAEILNKEIGAKRSWTGQYSVDCSKVPSLPALTFYLDNKPYTLEGRDYIFNVQGTCISPFMGMDLPEPVGPLWIVGDVFLRKFYTVYDLDKDAVGFAKAVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q853</accession>
    <name>A8Q853_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729661.1">
        <property type="nucleotide sequence ID" value="XM_001729609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q853"/>
    <dbReference type="STRING" id="425265.A8Q853"/>
    <dbReference type="GeneID" id="5853967"/>
    <dbReference type="KEGG" id="mgl:MGL_3205"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3205"/>
    <dbReference type="InParanoid" id="A8Q853"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="6">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="317" mass="35312" checksum="5234A0719E6DDC25" modified="2008-01-15" version="1">MAFYHALEERVRSLINEGRHVIVVGDMNVVASPRDHCESARVPAAEFSAHPARQWFQAILAPQGPLMDMTRHFFPERDRMYTCWNTLIDARASNYGTRLDYTLVTQGLEPWIQHADIQPQVHGSDHCPIYLDLRDSVETSTGRTYLVDLLHGEKDGMAAPHPLPRLATSRWDAYSTKTQPRLAEMFGAQRQRQAELIIPQAGQQEHKLNQVTTCTPETIPKSELPHEPAHGAAFHPASLAQSVGAKTCAASGTRSSKRVKKNHAQATLTSFVTKHVSDPPVTRPSKTLLSTTTNNTKRQDTAAQWSSLFTPHPAPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q868</accession>
    <name>A8Q868_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729670.1">
        <property type="nucleotide sequence ID" value="XM_001729618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q868"/>
    <dbReference type="STRING" id="425265.A8Q868"/>
    <dbReference type="GeneID" id="5853976"/>
    <dbReference type="KEGG" id="mgl:MGL_3214"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3214"/>
    <dbReference type="InParanoid" id="A8Q868"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="91" mass="10197" checksum="5151BC96B4D26E74" modified="2008-01-15" version="1">MIKDSETFKNADKEFQAKHDSRNDLEAYVHSVESTVSNPAATFKRAAKIQVEQELAKAMELLEVEDASADDYRRASLRLKRAVQKGLSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q884</accession>
    <name>A8Q884_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729679.1">
        <property type="nucleotide sequence ID" value="XM_001729627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q884"/>
    <dbReference type="STRING" id="425265.A8Q884"/>
    <dbReference type="GeneID" id="5853985"/>
    <dbReference type="KEGG" id="mgl:MGL_3223"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3223"/>
    <dbReference type="InParanoid" id="A8Q884"/>
    <dbReference type="OMA" id="LYCARHE"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="365"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="859" mass="93824" checksum="58855142BA500A43" modified="2008-01-15" version="1">MSQTGPASSPRESSLPGAPVAVLPRLKQLNAQPSSSSSSSSQKPLQSTQHLRPAPYGVLTQARSRSSSVASIAGSASPIDSSGISSAGSPSLRSVELPYLQRSVSPALSSSSKYSPQLRSSISTPRLQAEAGISFNDVASQWRQPVGSSPADGQTALRPSKPEVIASHATLSTSERTRTPPHAFFYEHTGTIDSTDAAALLHPSGETRGLGLSLSKPRVHDIAPINTRVRSPTPDSGTSSHMHMHIPLGPTLRSARSNAHFLGALRSRMSPEPSSSSHHDEGAPLWRSNTNLRRLFRMHEENGPRSRTTSGTSQSLMPSPGVVASPTPSPLLAHDSPDMPNPYATPESVAAPVFRSSDENRGERHRRYVLTELAETERSYASDMNVVKNLYLAQARLRSGIRPTTPSSSSSLSLMYASQDAPSSRTQSVSSEPDPEVVGAWSSANPPTFVSPSSESQPENRPPMLMPPMPGMSGGASAPLSVTDIHVIFAGVEACVTLATDMADLLAAAARNERPVSGVFLEKMPLIEQVFALYCARHEASIARLADVTTRSPAAAAFLRDCDDLSRQHSTAWDLPSLLIKPVQRVLKYPLFLQSIIECTDPSDPEYAQLQQALEQIQGVADRINESKKRMDIVGQHGFGLPSLSRTGFRRPVAPAGLRRAKTPTVDGPLTEDEDRFHALVARLNATEHTIRHFTQHCAMWMQNMRAMYTAEVRMIDEWIAVYACSDVHEPASLERLKQFRGLIHWRILNQACAQLETSLHRSVYVLINSMLILLERTQMVLMNRSAKEGEYRRYLHERARRPNTKGQCGALAFWSMHMQLVDEIPLLLRGTDFVMQRCILSLIRSAAVLLWSCGRHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8H6</accession>
    <name>A8Q8H6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729728.1">
        <property type="nucleotide sequence ID" value="XM_001729676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8H6"/>
    <dbReference type="FunCoup" id="A8Q8H6">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8H6"/>
    <dbReference type="GeneID" id="5854034"/>
    <dbReference type="KEGG" id="mgl:MGL_3272"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3272"/>
    <dbReference type="InParanoid" id="A8Q8H6"/>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="471" mass="50669" checksum="FFD7D37F80882C2F" modified="2008-01-15" version="1">MALKVPRAGGPHLFKDGYKHLQGIEEAVLRNIQAVNELSDIVRTSFGPNGRNKMVVNHLGRIFVTSDAATIIREMEVVHPAAKLLVYASQQQEAEMGDGTNFVIILAGELLRQAELLISLGLHPTEIVQGYELARDRALELLENLSIATLSTPPTQESLALALRPTLASKQYGHEEILAPLVAQAVSLVIPTSPSNTLRDFSVDNVRVVKIMGGSLSQSRVVRGMVFGREPEGQVKAVSAAKRLCRLLGATPLARIGAPMPEEAGFIDSAMTTEIGGDRVTVFRQEDGEKGGKAQPRLATIVLRGATTSMLDDTERTIEDGINAVKSLTRDPRLVPGAGASEIELARQIVAYGERTPGLNQHAIKKYGEALQVIPRTLAETSGLDATDVVSKLHAQHAATENADTGVDVEQTTDGTMSTVDAQVFDVLVAKHWAIRYATNAAIDVLRVDSIIMSKPAGIKAPGRNPNWDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8W5</accession>
    <name>A8Q8W5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729317.1">
        <property type="nucleotide sequence ID" value="XM_001729265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8W5"/>
    <dbReference type="FunCoup" id="A8Q8W5">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8W5"/>
    <dbReference type="GeneID" id="5853624"/>
    <dbReference type="KEGG" id="mgl:MGL_3352"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3352"/>
    <dbReference type="InParanoid" id="A8Q8W5"/>
    <dbReference type="OMA" id="RNHTWSE"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="104"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="448" mass="50195" checksum="5A454783B1EEE085" modified="2008-01-15" version="1">MAAVIDFPFALPAAPKNYAPTQASTSALSLTSVEVAPVGDAFLGHMRRQLHKSTFEDDDALMKQRLDEHAAANTEVNELDNDIGEEPESRELLESDPKEWKSLDHYAVLGLSSRRYKATDYEIKIAHRKKVLKHHPDKKVGATGLSDDAFFKCVAKSFEILSNPEKRRQFDSVDEGVDDDDVPTGKESPDRFYELWGPVFEREARFSKRTPVPSLGTKDSTKDEVDDFYNFFYDFDSWRSFEYLDKEVNDGSDNRDEKRYTEKKNRNERARRKKEDNARLRNLVDKALSLDPRIKAFRAAERAAREAKKNKGRPGAPSGKSAAEVAAEEQRKKEEAEKAAKEAAAKEEAEKAEREAAKKVREAAKKNLKKEKKSIRNIITGANYFQPEGVSPSATVLEKQLGALDALCGALEPEQVVALRESCEKGHAEAKAALHKACEDKGLGDAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8X0</accession>
    <name>A8Q8X0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3357</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729322.1">
        <property type="nucleotide sequence ID" value="XM_001729270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8X0"/>
    <dbReference type="FunCoup" id="A8Q8X0">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8X0"/>
    <dbReference type="GeneID" id="5853629"/>
    <dbReference type="KEGG" id="mgl:MGL_3357"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3357"/>
    <dbReference type="InParanoid" id="A8Q8X0"/>
    <dbReference type="OMA" id="SMRGCVN"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="405"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="847" mass="95044" checksum="A2F717E4767954FB" modified="2008-01-15" version="1">MDPQAWNQRRERPRSDLSGVDSIMNAYVERSDTPVTYMMMGEALEDAINVREPRPMTSPAQEQQQQLKPPQVPHKQTRLLDAPTIERTDRPYSPLVSQDIETFEPVTRSLSMNHTNLNLLRQSESTTSGVNLFRSSGNTESAYDDTFSYVLSKSDCSIKDDQDDGYIDSVIDNKTSRPASTASASSSDQDHIISQYIDSPKPSLVRRRPTEPSTPTYDRQGLRRQRLLSRARDRDADRDSLSSFGNHSGFDSDESLAKRSGSARSTRILPVPDMYAGTAADRSVVSLADQSSDQLLMQNDYNSLTLADAARVDELMEADREWDEKTPKLHQTFSMRGCVNMTMLILLLLSTLMLFLGYPVLHAYTEHRHNEARQTPVDTNLEAISALPRSRIDPSTPHDALTRQNTYNNKTMRLVFSDEFETPGRSFYAGEDPFWEAESLHYWQTKNYEWYHPSAITTVNGSLMIKLSQYAMEGLNFRGGLLTSWNKFCFTGGFVETKLKLPGRNNVSGLWPAVWAMGNLGRAGYGASTYGLWPYSYDVCDVGTLPNQTYLASQGGGPLAAETTGRYVEDFGPGLSYSPGQRLSRCTCLDSDDHPGPRHEDGTWVGRSAPEIDLIEALGNNGPEEHGQTSMSLQIAPFDAAYNVSDPSGLHATSSDKHGAIINDYTGAVFQQAVSAKVNTSDGAYTMTENEWDTYAFEYNPGVEDDSYIRWFMSGDQVFQIDAKALGPNNKTEIGARQIPVEPMYLIMNLGISASFSWINWDEIMRGWQEDSNNYAMYVDYIRVYQNEDEISEDSLSCSPSKYPTFEYIERHKEVYTNPHLTTWTEPPEKGGYNHSFPGNVMLGQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8Y6</accession>
    <name>A8Q8Y6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729335.1">
        <property type="nucleotide sequence ID" value="XM_001729283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8Y6"/>
    <dbReference type="STRING" id="425265.A8Q8Y6"/>
    <dbReference type="GeneID" id="5853642"/>
    <dbReference type="KEGG" id="mgl:MGL_3370"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3370"/>
    <dbReference type="InParanoid" id="A8Q8Y6"/>
    <dbReference type="OMA" id="RCASKAW"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="779" mass="87912" checksum="2F058442B46C86B9" modified="2008-01-15" version="1">MPQSKFCPRPTRTGRRIELGRQLHGSTAYGDESNHTSDADREQAKQQIELSWPRIYLRLINCYFSYAFTTVPVPEYERFAHAFNCSFGDPTLMAKYLNGQEGDEATCSYFHECLADLNPKDPASFVYATPETIEVLLTVICAWGAHFILLPFEQIDLHCFSHMGHKSLAQAAEMDPGLGFRRSDPAGLSCNGASGEGMKRRQKRRQGVACDTCRLRRVRCDLMEQPPGTKACTRCRVKRIVCTDRYIKWKRERDMLKNPSGTHALPDVQLLPKREEFLMMEEQPLPVQKLSQQELLEHGTTREAACNFFINRSLMLVHKYDLVNKCVVQSVIALLMLSSLLDYVRPDLSMDSHRVAVQHLKKLFGGTEFDLSIFLQSGPFFEQIKLLSPSVYSTWSGCVTPYFPMFPRDWYAVGFRTETNGPIRIQPVSQLLQFCEQLSPEMSLAMVMFLTHQLALVGHTLYDEIIVPTTSDKIPPSMPAFKSLYDACRRVWDDLYTVERALHVLLRNAAPHVTCLRPMNMLVCAIMVYSVLFLLYQIISKRINDWASSSQSILSFSDPSDEKEELISGIRELMRESQEHTLKICRTIAMYIHKLLPTGLVCRGTTLIRLTFRIAQVLSRATPVSEEMNEPSETPGQNDQTIHSTPLFDELLNPSGDATDNVSAFAGALPRFATGTATFVPDNEKSALASTKPWSSAPSGIRQGSSEMRHGSTKYAEADPDNINILLTTPLSRTLGPFTRNAKIKETDWCIEALGHIGFSYPNLGVEIRRIVDTMQAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q955</accession>
    <name>A8Q955_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729380.1">
        <property type="nucleotide sequence ID" value="XM_001729328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q955"/>
    <dbReference type="FunCoup" id="A8Q955">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q955"/>
    <dbReference type="GeneID" id="5853687"/>
    <dbReference type="KEGG" id="mgl:MGL_3415"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3415"/>
    <dbReference type="InParanoid" id="A8Q955"/>
    <dbReference type="OMA" id="AYHPTVA"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27631" checksum="32851C3D5247B6A2" modified="2008-01-15" version="1">MASVQQIVMHPYVSQVLKFWSTTVGRDKTSRAVQYLSRFLAWYYLTMGAPKETVTRFSSIKSNIGLSRKLFRIGKFLEHFQAAMKALSTPDIVLKVTAVGRQLGYALYLILDALQWAHGSKAYVFEKETYQKIAKNAARFWLAGLTFSLISGTYKSYNLIQRNKMAQRPKATAEKEAERRVELNQIAVETRAVRLQMLQDLCDWINPGSSTGWINANDGMVGLAGFVSSCLGARSQWIKVNGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q957</accession>
    <name>A8Q957_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729381.1">
        <property type="nucleotide sequence ID" value="XM_001729329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q957"/>
    <dbReference type="STRING" id="425265.A8Q957"/>
    <dbReference type="GeneID" id="5853688"/>
    <dbReference type="KEGG" id="mgl:MGL_3416"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3416"/>
    <dbReference type="InParanoid" id="A8Q957"/>
    <dbReference type="OMA" id="AGYYWAS"/>
    <dbReference type="OrthoDB" id="2425131at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="518" mass="56126" checksum="083AEFA563C9BFDE" modified="2008-01-15" version="1">MLRHAATDVRATTRVMANGLRASLLWNGTWKHVVVYPDNRAIHSAPLLLTQAELPGAVAATVNEADASPRDNANGTRFLPPMKKYPIPREEALSILEFIARALAHGEGPSGHSVDSFRVCSKQCEMDVLGILERGNVPVSALRKLASAVLQMNYEPQRLAIVGVMYGIASRRGDEDARYSWATMVMEGLLSTHSKQLDVLQAEAATAAYSQLARKGHARAQFGMGRLVLAKVLSKTGADAADKQVQMAVDLWQRAGRNGYAEAWYELGQLYHGGQFVPQDKLRALTCFEHGARGGSAQASHALGTIYLTRARTQADRAEMANAANSSALAARYFLQAAQKGHAASAYNMGLLYMRTSMSEKEHKARQGVLPDNRSAREWFAAAASRLFLPAMMNYGAILMEGRGRDDTDTPASDLEEARLVYTRAVKLCQKIEQQQQERSSSATLRGVSAAVKPDHDTSATARHMMETARAALKILDKQLLSSPTGTPSSSSAAASSLEASPQRGGSSHWLSSNCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q978</accession>
    <name>A8Q978_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_3429</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729394.1">
        <property type="nucleotide sequence ID" value="XM_001729342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q978"/>
    <dbReference type="STRING" id="425265.A8Q978"/>
    <dbReference type="GeneID" id="5853701"/>
    <dbReference type="KEGG" id="mgl:MGL_3429"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3429"/>
    <dbReference type="InParanoid" id="A8Q978"/>
    <dbReference type="OMA" id="KMDGTPT"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="19">
        <location>
            <begin position="2"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP42180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="545" mass="60419" checksum="70E25B1D0E789799" modified="2008-01-15" version="1">MKTLQERLVKRATAEGRESWLSDWWLSASYMSYRDPVVPFSSYFYLHKSVPKTTSGITRSAHLLKAMMAFRHLLVTEQLAPEKTKTGYLCMEPYKWMFNSCRIPVAGEDVSTSFDPAAHQHVIVVRNGHFFAVDLVNKMTGKELSVAEIEVQLDRIMNDSRTQKMASAPVGAFTAANRDAWLKNREALLSGPSAEQNRKALEKIESGIIVLALDSGKPVTFDERGVAVYGGDARNRFFDKQQIVVSENGASGYIGEHSMMDGSQTLRLNNFMVSALEAGKIELGGPSSGSVLDDPEFLSFDVNADLSNASNAAGQDFASLMDEQDMSVLDFTAYGKEAIKQYKCSPDAWAQMCIQLAFYKMFGHPCATYEAAQTRKFKLGRTETIRSCSLESLAFCQAMQDTNATDAERYEKFQAAVTRHVKNAKEAAEGAGVDRHLFGLKRLIQQGEEPPALFRDPMNAQSGTWILSTSQISSEVFDAWGFGEVTPKGFGVAYAIKNNALTFTIMCLKKVHSASRFTFFLNEAGIELRAMHDRLNQAKSASPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9M5</accession>
    <name>A8Q9M5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729473.1">
        <property type="nucleotide sequence ID" value="XM_001729421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9M5"/>
    <dbReference type="STRING" id="425265.A8Q9M5"/>
    <dbReference type="GeneID" id="5853780"/>
    <dbReference type="KEGG" id="mgl:MGL_3508"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3508"/>
    <dbReference type="InParanoid" id="A8Q9M5"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="295" mass="31584" checksum="3127BB2BB0D2FD43" modified="2008-01-15" version="1">MSLLARPAPFTSCMPPDWMTPTSTITSAPTATSAGTTADSLVPQSDVPRLEPPSRALASVRESPPAHPHHSELLRHIASRDRHPAEQRRSSSAPPCTNNVLQGSIPDIPGRQMTFDETMNWLFGQTVDTCNSPILQDASMSTPSALTSSPATMTPNCDACWPSCYFSSEESAGEHTKTLEQLENFALGTPLLALDSSTSAMLPATEMPIPPILLPPVSPKTQVPFNLQGVSNTACGGIGSQQALTTHMALDSPGSALNKVSDGQWQLPLPQNWLSVEPYESQNWETSHPFQGGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA83</accession>
    <name>A8QA83_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729175.1">
        <property type="nucleotide sequence ID" value="XM_001729123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA83"/>
    <dbReference type="STRING" id="425265.A8QA83"/>
    <dbReference type="GeneID" id="5853481"/>
    <dbReference type="KEGG" id="mgl:MGL_3642"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3642"/>
    <dbReference type="InParanoid" id="A8QA83"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211:SF1">
        <property type="entry name" value="ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ASH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14874">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1123" mass="122309" checksum="3689A28E9733F047" modified="2008-01-15" version="1">MFHTDKDADVTFQLAELALQRDSADEGDVPDDGVPLGGTSTSTARAALYETHDSPPAAASATLASNTVDPASKGEAPATPRVPDHIPLVANDSDRDSDISSNASQAGSRVGSPEPRLDLASQSSETDATTHHTSTAASTTSSAMLSGSVPSISPSLNTPAPVMGQRVASYSVSALATSQPRHRRHHDPVAMLSGVGESQYNQLEELVMRPGAQYRIVVSYRPPREPVDSEYTGGRLKHSSFRIYLDYVHAAENAHGGRERREIQCHLRTCTPFISVEPRVVDFGMASVGARMTAQVAITNHSELETRILLRFVSKVLSMYMDEIAVPARQTVELKMEFFPRRINESYRKQITVMNLLNRSNDQILEVRARNVDLQRVSFHSLFYRILTTSGSNFLDFGDVNIHSPSVRSFGIENLCATRLSLEMSVAHPEDLQLYVKAPQLHTTRSDHNRVAALKEQFLETISSDTPSHCSVPTKRIQHTPKSHAIALKRGSRGRASFQCGSSMAFRDRSLLLPLAFLDLAAGSPGADPRRRSSTRKHACKSPHGAGHSPPLRMSGRKPSETGRTVAGNASGAAGTTLAAETTAANMPTKSGVQGVHAVTSAARAKADIGLGSGSNEGVGTGPSTSMRSAGAAGHTRQQTQSPALTGTWYRATRFADPQDVAALDLDALISALEHQPASLSTFFVRNVEAEERLVRTEINLHRALHDAIASGQLIPTGLLNVPPHTVMQVVAVYTPHGSTRPHIQGNARKQDSRIFLRLLEFDMRRAEGLPEFEALRQRDVDELPVRDLMVRSSVCRSMLELGQPHINFGHMDKGDQRERKIWIQNRSEWALRYCIRKSGSIASGDIRLGRGRYGIVPGYGKRGVDFTFSPSLSGPFYERLLVENIADHDNDQAIVLKANVRKVANFAIDPTSLDFGTCSSQDLVSMPESVLLSNTTAKQRTFVVRLDDPVSPMLDVLVAMSNDSATRRALSSEEEEEVETLFQKLKIASRKGNLDKLAKYRDRLTQLGVSIPTAATSPSTEEPAAIPTTPSHDELKHYTLLTSGSAHDRSALTVTIGAQSSHKLLVRVRASSSALVSSSSIANPKANSTEHQPLDALVYLQIHENKNSDEKRHVIVRARIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAF1</accession>
    <name>A8QAF1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729243.1">
        <property type="nucleotide sequence ID" value="XM_001729191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAF1"/>
    <dbReference type="FunCoup" id="A8QAF1">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAF1"/>
    <dbReference type="GeneID" id="5853549"/>
    <dbReference type="KEGG" id="mgl:MGL_3710"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3710"/>
    <dbReference type="InParanoid" id="A8QAF1"/>
    <dbReference type="OMA" id="IVRIHAI"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF27">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="487" mass="53716" checksum="A1CDE3D26A0A67C7" modified="2008-01-15" version="1">MPTSNVVAIKQIALESSDADSEANMQDLQEIQREIASLAQCQDSQRVTRYFGSFVKKYTLWVIMELMDGGSCLSLLKRGGALPDEVSAVIARELVLGLDYLHAQGIIHRDIKAANVLLTRTGQVKLADFGVATQLIHRGSHRNTLVGSPYWMAPEVIRQSMYDAQADVWSLGITIMELATGRPPLSEYHPMRAMFLIPKATPPRLDVKKHDPGMVRFLDRCLVMRSKERAKAHQLRTDAWIESAGPLDLVRRTIEARGVSKPPDTSLSLHDSTLLDTSVISEWAFDTSGPSVHQDVSKVLGLNVGVPATQTAALDKPILANPTTPEESTPPPLQPPWPVTPSMSPARQPSTPSHRHHHDSHAFVTPRSQIMDSPTKSAAQRTPRLPVPDTPARIQLALEQLAFLAGQDASELAPVALVHQLHSLLSQLGRHTPEYLDMLVDMLTDPTAREGDAPRIPAARSRLASLLFERWHEALQARWNVLDTNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAF3</accession>
    <name>A8QAF3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729245.1">
        <property type="nucleotide sequence ID" value="XM_001729193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAF3"/>
    <dbReference type="STRING" id="425265.A8QAF3"/>
    <dbReference type="GeneID" id="5853551"/>
    <dbReference type="KEGG" id="mgl:MGL_3712"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3712"/>
    <dbReference type="InParanoid" id="A8QAF3"/>
    <dbReference type="OMA" id="PYWLLEA"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="204"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="48955" checksum="8B1C2C5A8E23285A" modified="2008-01-15" version="1">MDHGPPAPPPPLGDEAFGAVIQLANAASRPDHEQNHNSTNPHHFHHQHPSSNSAHTPSPRVSKGRGDDMSENPRSSKHVRMENESPHNSVDAPSLSWAPTAPPAYPGHGLDHNGMPTLHHSAPSPFDPTAHDVSAYGDTSGVQSDQSRMAPPPPAVASPTSEQNKHLTSEQTGLVGARGKTGMTRTLSTSRRAEQNRNAQRVFRERKNKYIADLESKAASLESALLAAEEHRRRFNEAIETIEILKRDNDTLRVALRALGGHQAVPNAPALPIDRPASHAPTLLPTFAQQHPGAPGAPPRGVDQHDATHAQSQGGMHDTAEQAQDPATAAAVAAAASGGAPYWLLEAVSNANQQHGFHVPNHFSSQLGDSGMPPPGPPTQIHPNDPNAMRARGGMPPQRAESMLDPSLEHAALGDAPRPPSRVHGEDNKTNDSGMDAPGNPDNLASLSAVAAAAAAAAASQKVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAI9</accession>
    <name>A8QAI9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-phytase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729281.1">
        <property type="nucleotide sequence ID" value="XM_001729229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAI9"/>
    <dbReference type="FunCoup" id="A8QAI9">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAI9"/>
    <dbReference type="GeneID" id="5853587"/>
    <dbReference type="KEGG" id="mgl:MGL_3748"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3748"/>
    <dbReference type="InParanoid" id="A8QAI9"/>
    <dbReference type="OMA" id="YRDDGWC"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725217" description="3-phytase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="59811" checksum="0C9C99E0F50A2FA3" modified="2008-01-15" version="1">MMLRLAAAGVLVLSAYASSDQKINWKNVTGTSSVTFPTDVGVAGDRATGKTPLNAEYDPLDTSRFQENYGIEMRWLPKDAEKNKASPDDIFTNLGPYTPWRPAKGLFPETEAYRSAPKECELKQVQLLYRHGARYPTDGMNEGLPKLVHTIANGIKNGSIKATGELDFMNNWNYTLGEAILVHQGAQELFDAGVKDYYSYGKLLDNIKQKPVIRTTSSSRMLDSARYWTLGFFGWDATDKMNMEVILEADHQNNTLEPKYACPNGKAFKFGSEMRETWQKVYLKDALNRFQRNLHGFNLTISHMADLISLCPYETVGYGYSHFCNLFTKEEWEGYEYGNDLKFQGNNGFMNPEGKAMGLGWVQEFFRRATKDSFKGPAAEKNMTLDNNSTYFPLDQALYADFSHDTVIMSILTAFNFTQLNDHLDPTKPDPSRKFRVSRIVPFGARVAFEIWNCQKTDFLRVKLNEAVIPLDQDQGCQKRKDGLCKLDDFVNHLQDRVIQEANFDLTCFGKNGTDFNATKPVDQGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAL6</accession>
    <name>A8QAL6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728987.1">
        <property type="nucleotide sequence ID" value="XM_001728935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAL6"/>
    <dbReference type="FunCoup" id="A8QAL6">
        <property type="interactions" value="693"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAL6"/>
    <dbReference type="GeneID" id="5853294"/>
    <dbReference type="KEGG" id="mgl:MGL_3775"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3775"/>
    <dbReference type="InParanoid" id="A8QAL6"/>
    <dbReference type="OMA" id="RGPNDYQ"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="558" mass="60240" checksum="992426CBED33C7F6" modified="2008-01-15" version="1">MAQIFQKDPRQAGLFIGGQRLSGSDIRDQNVLAVQSIANVVKSSLGPVGLDKMLVDDIGDVMISNDGATILQLLEVDHPAGRILVELAQQQDKEVGDGTTSVVILAAELLRRANELVKNKIHPTTIITGYRLACREALKYIQDVLAVKVDALGRESLINVAKTSMASKIIGSDDDFFAQLAVNAMLSVKTVNGRGETKYPVKAVNILKAHGKSARESMFIQGYALNCTVASQAMKTRIAGAKIACLDINLVKQRMHMGVHITIDDPDQLEKIRARESEIVLERVRKILATGANVILTTKGIDDLCLKEFVQAGAMAVRRCKKEDLRRIAKATGGQFVSSLANLDGEESFDASSLGHADEVTQERVGDNELILVRGSKVHSSSSVVLRGANEYMLDEMERALHDSLSVVKRTLESGSVVPGGGAVESALDIYLENFATTLGSREQLAIAEFAQALLIIPKTLAVNAAKDSTDLVAKLRAYHTAAQNADAADPKKTLRFFGLDLLSGAVRDNLRAGVLEPTMSKLRSLKSSVEAATSLLRIDDAITIPPEPPKEDPHDHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB68</accession>
    <name>A8QB68_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728892.1">
        <property type="nucleotide sequence ID" value="XM_001728840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB68"/>
    <dbReference type="FunCoup" id="A8QB68">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QB68"/>
    <dbReference type="GeneID" id="5853200"/>
    <dbReference type="KEGG" id="mgl:MGL_3886"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3886"/>
    <dbReference type="InParanoid" id="A8QB68"/>
    <dbReference type="OMA" id="LAIKDCH"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000207">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="331" mass="34885" checksum="7E60A32362469E63" modified="2008-01-15" version="1">MVVSESSKPLAFAVASWLHSQEDAQLKKAADSVCEACGFDTSSSADKDKYAKNSPGLQAIFDVFVKTQQKMNNTKDSGAVSDSGANVDTKHVSEEDSSKAESLKNDGNKYMSAKDYGAALDSYTKAIELNPYSPVFYSNRAAAYSQIGQHDEAIADARKAAEINPTFGKAYSRLGHALFASGQFAEAVKAYEKGVEVDPSNKLMKSGLEASKAKLSDSSSGNKDALATQAPSNGSNADPLAGAGTGTGAGAGGMPDLSTLMNNPMVAQMAQQMMQNGGLEQLMNNPMLRQMAENFGSSGQMPDVRAMMNNPQLRQMAQQFMGGMGGGAPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBX8</accession>
    <name>A8QBX8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728957.1">
        <property type="nucleotide sequence ID" value="XM_001728905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBX8"/>
    <dbReference type="STRING" id="425265.A8QBX8"/>
    <dbReference type="GeneID" id="5853263"/>
    <dbReference type="KEGG" id="mgl:MGL_3951"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3951"/>
    <dbReference type="InParanoid" id="A8QBX8"/>
    <dbReference type="OMA" id="TINCAPV"/>
    <dbReference type="OrthoDB" id="3349616at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="166"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="463" mass="53001" checksum="3137F3F0CF183548" modified="2008-01-15" version="1">MGYQASLHEGLEHASSQAHVPIQEGFTNEHRNLFDEWLMSNTFKSVVIREQYLMRLHVLHALANGHNSRQLLKDGVCSLSFIQKTRQNYSLNERGELYYHARKGKATLLVIPDDEVFDVIVREHNAIHHQGTSKTWYEISRRYHGIPKRAVDWVLRHCLLCHDHRPGPRPAPTQKISSHEVMERVQMDLIDMRREPDRKYRWILHIKDHYSRFCMLYPLRRRRGKHVVRCFLQWIATMGPPMILQTDNGVEFVNALITQVAVQHQILIRRGQSGRPRSQGLIERANGHVRNLIAKWCNRFGENRWSRSLPSIALACNTSVHSSTRRTPFEMVFGRAPSWQRLARLDPLDPTLTNMELGLEYEQQQSQSSVDTNGPPTPSPVRSVVPPMALSPPSETLPSPSPPPSPSPSPSSSSSQRISSDDPSALVSQSRKTTSVPIVNQEPIPREVYFRRGTRVSTLTSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBY2</accession>
    <name>A8QBY2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_3952</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728958.1">
        <property type="nucleotide sequence ID" value="XM_001728906.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8QBY2">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBY2"/>
    <dbReference type="GeneID" id="5853264"/>
    <dbReference type="KEGG" id="mgl:MGL_3952"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3952"/>
    <dbReference type="InParanoid" id="A8QBY2"/>
    <dbReference type="OMA" id="NREDYQQ"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="16">
        <location>
            <begin position="302"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1331"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1365"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP41744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1673" mass="186177" checksum="4FF3D6547DC1A809" modified="2008-01-15" version="1">MNHFECPGHFGHIELPAPVFHPLFMNHAYSLLRGTCLYCHHFKISKMALAKYTAQFHLLEYGLVDEAERIANEQFRGPHSAGVDVVEEGANEDGDDDDDEPLAQLQNDNQPAETVDDFIRRIRQAVHRLTAQARKCGIRRNADKGMATYSARRDLRNLFLKDIMRRRCERCQAINPTLRKDGFVKITERDLSARDHAIHEARGIKRQNVLMDRASTMTVRDTNGQTIRAAGNEPDSESTIETAITLKEARKLSKEAGDHTRVVPASECRANLRRLFANESEICSLIFGRHPMFGSTPAPSADVFFLEVICVTPTRFRPASVMGDQTFENPQNELLTKILNTAFFVRDCNERAQVYQTKANYPVLDEMNEQQAITAQKQWEMDRRAAMDQLLSAIMQLQVSVNCYMDSSKNPAPQRQGQAATPGVKQGLEKKEGLFRKHMMGKRVNFAARSVISPDVNIETNEIGVPPVFAKRLTYPEPVTVHNYELMRQLVINGPDVYPGAHAVRGEDGTDTLLKNLSVEERTALANQLLTPQGQTSRQARGTFGGIGGTLRTPVINKQVLRHLRTGDILVMNRQPTLHKPSMMAHRARVLQGERTIRMHYANCNSYNADFDGDEMNMHFPQSQMARAECYNIANTDNQYLVPTSGNPLRGLIQDHVVGGVWMTCKNTLYTRDEYQQFIFGAIRPETYGQGGRIRTLPPAILKPKPRWTGKQVISTILCNVTPPHAQGLNMDAKARVGAKYWGEQHKEEEMVVVRDGELLTGVLDKSQIGASAYGLVHAVYEIYGAESAGRLLSIFSRLFTMWLQHNAFSCRMDDLVLSSEGDATRQKILKDGATHGLEAALNNVGLGDGDSKAPETHRNLRVRLEEVLRDDNKLAALDAAMMSASNKLTSSVISSCIPSGLWRVFPENNMQMMAVSGAKGSAVNVSSISCLLGPQALEGRRVPVMVSGKTLPSFKAFETAARAGGFVAGRFLTGIAPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGISVQYDQTVRNSDGFVLQFHYGEDSLDVSKSKYLDRFDFTIQNFESYRRRYNPVQLESTMEVEKAPDYMKRALKKPYKYAPVMSVYSPARHFGSMSETFAQKVEDYVSKNPRALLARKKKDSASEGVPMQLAHPKLSTEAFRAMTKVLYHRGLVEPGENVGLLAAQGIGEPSTQMTLNTFHFAGHGAANVTLGIPRLREIVMTASKDIKTPVMRLPILDGVTNEQMRIFCKDGSRLVLSQIIEEATVTERMMPKTPANGYQRQKLYTVRLQFYPADEVKQEYNASTEHILSGLEATFVPLVEREIVRELKRLRRDQVRQSQSIGRGETFNESMAERDADVPIYRNAAANDSDDEDERLSEAGDDDDDATAAKRRANAGSKVSYDDAADAEDDRAKDTTDDITRAFNDADDIEDGDEQALSAQKDVGDEAIDARVTELDERLQNESKFVVSFRFDSVAGAWAEFDLQMLNSTEKMLLINVIERVCRASVVHEIPRISRIMIPPPVPGDPSVALTAEGINLPGMWDFGFGVVDLDRIYSNDIGALLYCYGVEAARAAIVSELKGIFDTYGIGVSMRHMFLIADYQTAFGDFRPFSRGGLADAPSPLLKASFEMTMAFLSGASLFQEMDDLTSPSSNIVVGRPVRSGTGATTVHLPLAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCL8</accession>
    <name>A8QCL8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_4023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728856.1">
        <property type="nucleotide sequence ID" value="XM_001728804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCL8"/>
    <dbReference type="STRING" id="425265.A8QCL8"/>
    <dbReference type="GeneID" id="5853162"/>
    <dbReference type="KEGG" id="mgl:MGL_4023"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4023"/>
    <dbReference type="InParanoid" id="A8QCL8"/>
    <dbReference type="OMA" id="PRTRFMD"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="264"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="295"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="683" mass="77244" checksum="6919569BC13FF3D8" modified="2008-01-15" version="1">MSTGHASGTSLLDEVFLNEDHVRTYESYLAQIDEAKKAGQVPRIRSVSAVSDFAPICEMVDVGNDPKDDKETKEDRSVPEGWTYGALRFPLLFFVLWLISLDFCLYILVRQAVNVIEKVSAWHGMSGKLRRRLQTAYTYRDWKRAALDFDAYRNYDEWKSHDASPFYDWRLVQRVVRAMRLAREQDQAQALMGILTLCVKQGFAGIENLELYSQSFYGTKQLIERYYYEVEESLAYLESTPNVSAPVKSAFYRAVFLNFGRSALCLSGGAAFAYYHIGVARALLDANLLPNIVSGTSAGGLIAALLCTRTNEELKELLVPDLARHITGCDDPMHVWIARAWRTGARFDTSKWARKVQFFTRGSLTFREAFERTGKTLNISVVPFEQHSPAQLMNHVTAPDCIVWSAVLASAAVPGILNPVCLLQKLPDGSIIPWSWGNQFRDGSLRVDIPLESLNSMFNVTHPIVSQVNPHVHLFHFGSRGAPGRPTAFRRGRGWRGGFLLSAAEHILKLNLLTNLAILRDLALLPKILGQDWSSLFLQKFQGTVTIYPKSRLKDWPRILTDPDATELAQIIHSGCYVTYPKQHMISHLVRIERAILRGKAHFQSRSHVHDTCEHELRDAAIEASDMLQRPLAKEDVAGSKDAGPSRSSNRQDDRLFQEHSNLLELRPEDLEHLLDRFQDEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCS6</accession>
    <name>A8QCS6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative peroxiredoxin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_4042</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer; disulfide-linked, upon oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728875.1">
        <property type="nucleotide sequence ID" value="XM_001728823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCS6"/>
    <dbReference type="FunCoup" id="A8QCS6">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCS6"/>
    <dbReference type="GeneID" id="5853181"/>
    <dbReference type="KEGG" id="mgl:MGL_4042"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4042"/>
    <dbReference type="InParanoid" id="A8QCS6"/>
    <dbReference type="OMA" id="HVPEYIQ"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="15"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="11">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP41661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="184" mass="20007" checksum="DC84FCF2825D67A1" modified="2008-01-15" version="1">MLPVVSFRCLTVQAIEKGATIPNTKMGLIPWAPELDSGEVCGVPTSFETHKEWKGKKIVVVSIPGAYTPICHQQHIPPLVKRADEVKAKGVDAIYVIASNDPYVMSAWGIFNNAKDKVVFASDLNIAFSKALGATIDLSFKDMGERTARYALIIDDLKVVDFGSDEGDTGKLQNASVETILQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD33</accession>
    <name>A8QD33_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728766.1">
        <property type="nucleotide sequence ID" value="XM_001728714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD33"/>
    <dbReference type="FunCoup" id="A8QD33">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD33"/>
    <dbReference type="MEROPS" id="T01.976"/>
    <dbReference type="GeneID" id="5853107"/>
    <dbReference type="KEGG" id="mgl:MGL_4101"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4101"/>
    <dbReference type="InParanoid" id="A8QD33"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24506" checksum="F395F8B9A23F5CE2" modified="2008-01-15" version="1">MRQLALSSRLMYTRPLPISRLMGALADRAQLNTMQYGKRPYGVGFLVIGTDDTGPHLYEFNPTGNCFEYYAMSIGARNQSAKTYLESHFTEFTEADLDHLILHGIRALRETLPQNKQLDQASVTVAYVGPGADADPHSSSLREGQKFTVLEGDKLATWFERLGPSERQRAAAAAAEASAAAATENASSSADNAAASTDNASSASAPDQNTQASSDNTDNQPRPMDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDE0</accession>
    <name>A8QDE0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728713.1">
        <property type="nucleotide sequence ID" value="XM_001728661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDE0"/>
    <dbReference type="FunCoup" id="A8QDE0">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDE0"/>
    <dbReference type="GeneID" id="5853012"/>
    <dbReference type="KEGG" id="mgl:MGL_4192"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4192"/>
    <dbReference type="InParanoid" id="A8QDE0"/>
    <dbReference type="OMA" id="LHPFEVF"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000051">
        <property type="entry name" value="Glutathione-independent glyoxalase HSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="32"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="240" mass="25746" checksum="FCB65A4E365052A7" modified="2008-01-15" version="1">MPASVPRRALIAVTSAHAQLYPNGGETGVFITEALHPFEGFRKAGFEVDLVSETGKYTPDALSMTKPWITDEELKVYEDKNSEFRQKLDNLKKPSDIDPTKYGLFFASAGHAALIDYPDDKGLQEIASKIWEAGGIVSAVCHGGAILPGVKDQSGKSIISGRKITGFTDKGEEELGALAEIKNWNRPTIQESAASAGAEYVHPPGPWAPYQVTDGRLVTGVNPQSATVTTEAAIKAFDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDP4</accession>
    <name>A8QDP4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_4225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6 8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6 8">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000023">
        <property type="protein sequence ID" value="EDP41412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728626.1">
        <property type="nucleotide sequence ID" value="XM_001728574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDP4"/>
    <dbReference type="STRING" id="425265.A8QDP4"/>
    <dbReference type="GeneID" id="5852945"/>
    <dbReference type="KEGG" id="mgl:MGL_4225"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4225"/>
    <dbReference type="InParanoid" id="A8QDP4"/>
    <dbReference type="OMA" id="WWSYRGR"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09087">
        <property type="entry name" value="Ape1-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="10">
        <location>
            <begin position="73"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="342" mass="37846" checksum="2361F41A91E1BBAE" modified="2008-01-15" version="1">MPKRAATTATTDAPKRPRLQEDVKQLGPTAASPAAPSGRDHVAPDKIPRNTQLPKGPLSIEAKPAGCTRIAIWNITSLKSSDAKGLMRYVHAEDADVLVFSETKVNETPSHAGLDAMYKYRYWGIGEKKGYAGIAVLSKQKPIHVEKGLPGFHDPSSNARLLTVEFPHTVLVATYAVNAGDGLKTLGNKNAWNEALEKHLQSLPSDKEVIWCGDLNVVWDDRDLAGASKKWNKAAGYTQAECDAHRRILATNDMCDAWRECHPDAVGHYTYYGWRGQCRSRGAGWRIDSFIIRKRALSRVKACEIRHEIYGPSDHVPMRSLFSRVQILDPSLAKKKSASTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8QEF4</accession>
    <name>A8QEF4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_4267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000033">
        <property type="protein sequence ID" value="EDP41381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728595.1">
        <property type="nucleotide sequence ID" value="XM_001728543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QEF4"/>
    <dbReference type="GeneID" id="5852903"/>
    <dbReference type="KEGG" id="mgl:MGL_4267"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4267"/>
    <dbReference type="InParanoid" id="A8QEF4"/>
    <dbReference type="OMA" id="MKSAYTV"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725591" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="95"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="387" mass="43207" checksum="A32EA6C0B98BDEDD" modified="2008-01-15" version="1">MSTPRTLAFLAAALWCAFAIVSAEFTLELKRDAGSSAPNPTNDKALLDGIVAKYLRNAESYYKNTGKHARFVNSTKLKKRGWLGTASLGMLEQNWNVQLEFGSDKQKLYVKFDTGSPDVVMDGRGYDPSSSSTAKDLDTPFEAGYGSAHAAGKVYTDTIAMAGIEAKDVWISVSDDPFLTMNRDAGLIGLSWPVLSSLYSRETTFYEAFKQQKRLRRNVYQFTLKSHATSHLDVGHVNRMRFLGLVGWVSVNPDDGYWKTDVNINGDDYTGIIDTGTTLIVASNEKMKSLLSKLDGVTLKQDDEGNYQGWYDCKKPPKISFRVGGKRFTMPRKTMKYWQNGNECRLPFTGLDGFSDWIFGTPFLEMASVVFDFDNARLGFASQSWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQX0</accession>
    <name>A8PQX0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732751.1">
        <property type="nucleotide sequence ID" value="XM_001732699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQX0"/>
    <dbReference type="FunCoup" id="A8PQX0">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQX0"/>
    <dbReference type="GeneID" id="5857057"/>
    <dbReference type="KEGG" id="mgl:MGL_0526"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0526"/>
    <dbReference type="InParanoid" id="A8PQX0"/>
    <dbReference type="OMA" id="FPVAKQY"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000094">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="70091" checksum="3F4BF747E6E81A3E" modified="2008-01-15" version="1">MMLEKFAQRHEDCVLFASPQHASQCRDFMRAMKQRESPGSPTLPVRVVRFSVLAHPTQDSTTVRVPDPSDATIRLYIVLFDRDVFPLAKQFWQHTGVGISSRIADECMRILAHNEALLEPCGGRCAPSPSLGPRRGSSSSASASAGVTARGGGFGRTRYQSRGIDAWGSSVPSSRRTSRSSSTAALHEPAASEDEELAYEHDVFVEERFGRNLPIALAQDAKIALRRRIAGTLVGELAEEPVERAVSARQVSGVSENDVFLFPTGMNSIYHAHQTLMLERAMIQQGVPMTKKAIQAAMRTMADPSFVGPKQTIGKSVCFGFPYTDTLKVLQKWGPGCHFFGRGTDDDLDKLEALLAQQDDQAPKIHALFCEFPSNPLLRSADLPRIRRLADKYDFSVVIDETVGNFVNVEVLPYADMVVSSLTKVFSGDCNVMGGSLVLNPQSKRVESLRAVLSANYQDTFWMEDAIFLERNSRDFVARISRIDRNAEAISDYMFSQSQAGGMKDSIISSVYYPKYVTRHHYETCRRKQPYDTSSEGAKQGGFGGLLSIEFVTSTTAQVFYDSLACAKGPSLGTNCTLACPYTLLAHYAELDWAAEMDVSDKLVRVSIGLEETNALLHVFATALDAARQAQAQAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR55</accession>
    <name>A8PR55_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732833.1">
        <property type="nucleotide sequence ID" value="XM_001732781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR55"/>
    <dbReference type="FunCoup" id="A8PR55">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR55"/>
    <dbReference type="GeneID" id="5857139"/>
    <dbReference type="KEGG" id="mgl:MGL_0608"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0608"/>
    <dbReference type="InParanoid" id="A8PR55"/>
    <dbReference type="OMA" id="RVEYDNQ"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41701" checksum="DBE3FA801144D0AA" modified="2008-01-15" version="1">MQCIENCDDVSAANRVYYSQPVWQTLQMFMGEAWCLAIYGLSTMRQKYRDKQASNNGDQREREVLLISSNSPSQPSYGTNIPYSALGACTTDKPWYIRSLEFFFPATCDILATTLMNLALLIMPVSVFQMTRGALVMWVGLLSVIFLRYHMLLYEWLSLVLVMVGVCIVGLSSLLQSAQSDTNLYILALLKTKSHETASQTLLGLAMVLGAQVFSATQFVWEEKVMEQHRVDPLLVVGLEGIFGICQITVGMLLMHYFVGSTRQGEGGIFDLRAGWSQTLGVPSVRMSAFLCATSIAIYNALGLNVTKDLSATARSTIDTLRTLGICAVSLCLGWEVLRPLSGSVQGLGFAIMAYGTFVFNGVISAPAFLLRRSPVAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR73</accession>
    <name>A8PR73_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732846.1">
        <property type="nucleotide sequence ID" value="XM_001732794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR73"/>
    <dbReference type="FunCoup" id="A8PR73">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR73"/>
    <dbReference type="GeneID" id="5857152"/>
    <dbReference type="KEGG" id="mgl:MGL_0621"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0621"/>
    <dbReference type="InParanoid" id="A8PR73"/>
    <dbReference type="OMA" id="GCSIDYR"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727841" description="L-type lectin-like domain-containing protein" evidence="7">
        <location>
            <begin position="28"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="42"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="359" mass="40863" checksum="84E65B647631AA14" modified="2008-01-15" version="1">MVVKMAGRVIVSVVALMLVALSRHTNAARSSTSNPDLRADAIMPIRTHSLFAPYVDSSLQNNFWDYGGDAVIDTNRYIMLTQERKNESGWIWSRLPINATDFEITSEFMLKGKSTTVAGDGFAMWLTSDRAKQGPVFGSMNQWKGIGFMFDTYANTPHRGFFPRVSAVSNDGTKVYNMNNDGEGQDLAQCAMQLRQTPAETRLRFTYVKDVYMELAIQNREWNQWNSCFKVPPPPFSEPPFLGFTASTGDVTDSHSIVSVWTNKIVYNSRSPEDLERERQLAFADDRSKSWWSSKDEKKTPSNHGSDLLVHVIVRFFLSVLWLLKWIMVIAVIVVIGVIGYEMFKRKMQAAYKNRRMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR84</accession>
    <name>A8PR84_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycoside hydrolase family 31 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732853.1">
        <property type="nucleotide sequence ID" value="XM_001732801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR84"/>
    <dbReference type="STRING" id="425265.A8PR84"/>
    <dbReference type="GeneID" id="5857159"/>
    <dbReference type="KEGG" id="mgl:MGL_0628"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0628"/>
    <dbReference type="InParanoid" id="A8PR84"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725334" description="Glycoside hydrolase family 31 N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="7">
        <location>
            <begin position="87"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="441" mass="49207" checksum="DD99D31C93F9A5A0" modified="2008-01-15" version="1">MHLRTFCWVLAFLAWAATLVVSVRPGDFKACKDSSVCRRFRQVSEQVESFPSYVSPYAVAERVAKVDDAKIHLLVRTALHDVSFDMNATFFADGNARLQMDEHGPTYKDWRHYPEANVWGIAQMPALAEEIHVTHPNEAKTVVSWGADKSGNMHEMHIDHAPLRISFLRDGVVQMMLNERALLHMEHFRPKPEGGMPSTDEQRAAFIEERVRVLKARHPTASPALIDMWSKFETPDEGEWEESWGGVHDSKPKGPEGVALDISFPGYDTLMGLPEHASPLSLRSTRAPPHGEADDEPGRFSDPYRLMNTDVFEYEYDSPMALYGSAPVVHALSRSSAVSVLWMNAAETWVDIHKSKQRPGPAVDVMSLGASHADALALEWGHVGEVIACALHVRVGHLDLFVFMGTNARAQHGALHVARRPHSATAVLCHWLPPMPMELLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR97</accession>
    <name>A8PR97_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732227.1">
        <property type="nucleotide sequence ID" value="XM_001732175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR97"/>
    <dbReference type="FunCoup" id="A8PR97">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR97"/>
    <dbReference type="GeneID" id="5857168"/>
    <dbReference type="KEGG" id="mgl:MGL_0002"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0002"/>
    <dbReference type="InParanoid" id="A8PR97"/>
    <dbReference type="OMA" id="HKRDICY"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="59901" checksum="D537F89221F022C7" modified="2008-01-15" version="1">MPKVKREVSEDSSCDKRRRGKAHKGGDPFTLISQHNLKSQGAIDPPSFYRERLSSSQGDGTTLSSLRLFMNDMISRVDLPHQSLLWRIDWNPPMVLWDACPNWSPADSAHEATPLKLYVQSYEQKQAMSLQPLTSTATIDPSNSSHLIHMFDAGGHIYDLDWAPCTNSSIQWLAVACGNKDAHTRVKYGCCGSIQLWSYDTNISMKHVHTIKLDDGEPLQISWRPGAPAASTIGTLAASMDNGDIVILDVPKTEASCLYLSPRTTLRVPNSRCYSLAWGGNARLAAGCSKGQVVVWDLDESDSPMINVSVHDTLVCALSWQMLPPLDLLGTPNLSARPHILLTVGWDGSEHITDIYDVYSTTRYGHSREPRYATVWAPWNGAWIMDFGDNQFGTVSLRTHDIGRHHMLGIHHGRIISLAASAFHPYIASGSADGSVNITNALNVSKRKAMEEGGRLVHKRFRLIQNDANTYTIRHGFYPEGVLPRSQTQKSAPLSIDRWDPSVCITSVAWCPNDGHSLLLASGTGIGLVRVEWIEAPLSMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS02</accession>
    <name>A8PS02_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732391.1">
        <property type="nucleotide sequence ID" value="XM_001732339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS02"/>
    <dbReference type="FunCoup" id="A8PS02">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS02"/>
    <dbReference type="GeneID" id="5856697"/>
    <dbReference type="KEGG" id="mgl:MGL_0166"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0166"/>
    <dbReference type="InParanoid" id="A8PS02"/>
    <dbReference type="OMA" id="ATMPIFN"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="308" mass="34514" checksum="4279C3CF6C23B0E5" modified="2008-01-15" version="1">MQLKIESRGNIKGAYFPLEINLPDDATLGTLKNGIANLVPTLPVARQRLAKADKQPLVDDEKRLSDLGVEGTAALTVKDLGPQISWRTVFLVEYAGPLIIHPLIYYGAPSFWARFGYSYNTSSIQTIAFVLIMAHFVKRELESLFVHRFSNATMPAFNIVKNSSHYWLLSGLVLGGGLYSPSLGTEAVSGTLRNNRVFLAICACVWLVAELGNLHSHLILMSLRPKGTRVRQIPRGGAFELVSCPNYFFEAVAWFAITIMTHSLSSLIFLVVSSVQMTLWAVKKHKNYRKEFGAQYPRQRKIMYPFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSB6</accession>
    <name>A8PSB6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_0228</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732453.1">
        <property type="nucleotide sequence ID" value="XM_001732401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSB6"/>
    <dbReference type="FunCoup" id="A8PSB6">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSB6"/>
    <dbReference type="GeneID" id="5856759"/>
    <dbReference type="KEGG" id="mgl:MGL_0228"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0228"/>
    <dbReference type="InParanoid" id="A8PSB6"/>
    <dbReference type="OMA" id="NFCPLHD"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="19">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="198"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP45239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="245" mass="27636" checksum="30BC194E6683D2DA" modified="2008-01-15" version="1">MPVERMPPPLSARWEDDMDVDACRKCQRKFTLFFRKHHCRRCGRIFCDACTSQRAQLPEDVHVTDPSSPDMLELESGYFVRVCDWCVDEYDIVTESGSTPSSDVKRPFLSRIIRLSPFTSTANSPASSSNESGLNASTSVLTECPVCDLDLMSLSSTEERERHVADCLEHGPRSNWARRTNFLVSSLTNDSALIGKECIICMDDFTSNDRIARLACLCYFHADCIRHWMEKGHACPVHANVSDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSG0</accession>
    <name>A8PSG0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732476.1">
        <property type="nucleotide sequence ID" value="XM_001732424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSG0"/>
    <dbReference type="FunCoup" id="A8PSG0">
        <property type="interactions" value="425"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSG0"/>
    <dbReference type="GeneID" id="5856782"/>
    <dbReference type="KEGG" id="mgl:MGL_0251"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0251"/>
    <dbReference type="InParanoid" id="A8PSG0"/>
    <dbReference type="OMA" id="PLCKHHY"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="6">
        <location>
            <begin position="135"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="889"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="899"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="977" mass="109212" checksum="B661501463B41776" modified="2008-01-15" version="1">MQQARKQPVFDARPLTDTFAQAIRELQSIKGKMLERSTALNSAVQVSQSVYTKKLRQLTNNFDATQSSFDSLQARISEVGRTAIRIGEQLEALDRQRTRANETQDLIEFYYMFARGSSDRLDKLRKEGGREGRLKAATILRRLAVISREVDIEGSNETRGFIERYCEQFERDMLRLFDKYYRRSDPKMMSHIAHVLQRFNGGMSCINIYVNQHDFFISKHRIVEAEKIGASPEWSQIADPNSVPPRSEPSLDALYTEIKRTVELEAQIIAAVFPTPLLVMQLFLRRVFAQSVQTYVETIMQRALDADAKVLGTTRHDTSIDVAGLAFLRMLHVTRSATLMLVADLKTIDLRSAGITITSTPYSSSSLDGLFSMGNHEADGLVTSDGYSSKQLAAAGGSVLGAMLDQHVEELFFQFLEQVRYMDRECHVLSGLYAQALHRFFTWHQNTIKASRANATIFSRVREQFTGGTGSFGSSVAFSTLSESAGYGSGTTPQVSSFKRLVDRARGLSIPDENTAVPLGHDPDEHGELSLELAERLLRWHAEALGRCVDLCASSDVPKNTFNLLRVLTDAYLKAYVEAALETATVQMFGYDVRGAAPPDLRVLSLVQRVEELSELWQHYVQTAVLPLTASSVTIRRETNIYNNHNMLRVEGKCEALLQKYTDNLLGFMAARLATQKRTDYCPRNDDVALTQLNTEPCLAIVDALESLDQEARRTLSERTRESLYTEVGIGFHALLCEHLKRYTVNATGGLMLTKDLAMYQDICGRFGVPIVNDRFEMLRQLGALFIVQPGVLKSYMREGHLSNLDETLLRPYLLRRQDYSRDVRTLDDASDASTDDATGRTATLLASFNQHSILSGPWASEKKSDFSRDVPSFVTDVPDLPNVIEQLVHPPQERPGSARSSRGDSSPARSNTPQSVPLSMQDSPRASGHAGQESRTDRFERASSPMKDSSSGSTGGLMNRDRLSNLHNLVQDLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSH4</accession>
    <name>A8PSH4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">eRF1/Pelota-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732483.1">
        <property type="nucleotide sequence ID" value="XM_001732431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSH4"/>
    <dbReference type="FunCoup" id="A8PSH4">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSH4"/>
    <dbReference type="GeneID" id="5856789"/>
    <dbReference type="KEGG" id="mgl:MGL_0258"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0258"/>
    <dbReference type="InParanoid" id="A8PSH4"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="446" mass="49074" checksum="36FDDCACAA6F25EF" modified="2008-01-15" version="1">MKIFARHLERNGSGTVSLMPECDEDLYHLYNLIQPEDRVSASTVRRIQSESSTGSIESQRMRLQLTLSVTKIDFEMAAGSGMSSAASSTAVIGAPHEPVSSDSEPNSSVSTPMSSLVLGEAGSTPSLSGASQGQPTLHISGRVAEENKHVRNGSFHTLDIELNRKMSITKEQWDQYHLDILEESGDAGKSAEVGAVILGEGRAIVCLLTSHMTIIKQRIQVALPRKRAGAGYGNAQTSSGTVKITDRFQAQVYDAVIKLLSLPEMRVVLLASPAFYRENMYEYLLAEATRRSEKLLMGSEGKRKLLKVYCATPHVHSLMEVLQSPEVTSQLQNTKFTRETQVLDQFLRDLARSENYAWYGERPVVLAAERGAIKTLLLSDAFLRNTHPNIRKQWIELCDKVKGFGGEVCIFSSLHESGRQLNGLGGVAAKLSYPLDLDMVEEEESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSM5</accession>
    <name>A8PSM5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0284</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732509.1">
        <property type="nucleotide sequence ID" value="XM_001732457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSM5"/>
    <dbReference type="STRING" id="425265.A8PSM5"/>
    <dbReference type="GeneID" id="5856815"/>
    <dbReference type="KEGG" id="mgl:MGL_0284"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0284"/>
    <dbReference type="InParanoid" id="A8PSM5"/>
    <dbReference type="OMA" id="VNWEDQF"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="390"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="809"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="951"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1129" mass="127468" checksum="6D2D3388C85C0D4D" modified="2008-01-15" version="1">MSRHPATSKSFDVPRTPTSNHKTILPPKHDMPKALANSDDLDELEVLEVSSSSPRKRARADSSEVETRTWESFAPNPVYTMTSWVCLGMFRPSVLCMYGLPPELRNDTPDANALVNRASNGISFWAEPGYHPVCIHQSGSSSFSHNMYSSFLRTPATSYDLAVSTLKPSTHTASQPVALNEYGRVSEKVSKMLQPLLQHGVVHCVSRASLVSPLKARAFAQQIETLIFTRGSNELAVLQALRLAGITLEVPTTYRAQDYPGAPTLRVPLQPQVEETLPEQIEPLYMTPMLSSQTRIQQDDPHAQINAIYAALEQTEKLDETEAGPLIVTSLFSHQKQALTFLLERERQRDFLELLRKDNPPNHISLWTILKRADSTIDKYKNTVTGLTRRGRPSVCRGAILADDMGLGKTLTTISLIAHTYDEACTFGQSELKGDGEDDDDEPLLIGDSRNKRTAEQARMEELRCRSRATLLVCPLTVVSNWESQIREHWHPDKQPTVYVYHGSGRTTNPHVLADYDIVITTYSTLGNEFSNQTTWSAAAGRSDEDISSTPKANRLESPNTCQRVEWFRIVLDEAHIVKEARTWQSKAVCNLSATRRICLTGTPIQNRIDDLYALLVFLRLDPFVDRAVWSRFCGDRVHIRLNSASSGVKLDPDSLKRVQTIMKFLTLRRMKSDTKADGQPLLKLPPKSTRIVTLEFNESERAKYERLHSRFREEFIGYVSEGTVGLNYTTILHEILILRMMCDHAALVDDSIKNQSLEQAENHELDDQQQKQHAMLSMNSYPKQSVTLDRQHHTKIRSTIGQGDLMYCALCQSDCVQIDEDVMRRPVMTKCQHLLCGACAQEHLDMAWPSTGAIHAVRICPVCERPLDVESEISPHQSDVAGEGIEAHVTPQDTGETGPFLPLKPETWPASWSTKLRALISDLLPFSRCNPSSELFDPSAPILDHCVKEDFESQTTSVEVRVCRRHEPRPNPIKSVIFSQWTRMLAKVKEALLHAGIGFRQLDGTMKREHREGAMSEFQQDPKIEVFLVSLRAGGFGLNLVAGCRAYLLDPYWNPAVEQQGLDRIHRLGQKRPIVMTKFIMQRSIEEKLLELQKRKLELASQVGRRTDRRTDHDAKQQRTEDLRLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PST7</accession>
    <name>A8PST7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732539.1">
        <property type="nucleotide sequence ID" value="XM_001732487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PST7"/>
    <dbReference type="STRING" id="425265.A8PST7"/>
    <dbReference type="GeneID" id="5856845"/>
    <dbReference type="KEGG" id="mgl:MGL_0314"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0314"/>
    <dbReference type="InParanoid" id="A8PST7"/>
    <dbReference type="OMA" id="ERSHYED"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF62">
        <property type="entry name" value="LEUPAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="408"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="542" mass="60620" checksum="5F6C8753B0E041A1" modified="2008-01-15" version="1">MKSSLSEWDRPNLAGVGVSRFHQTFPQHRQFGPLFQGPNSVLCMQRTPQPEFVVATGVENQLAATQSRLSCGRFPHFAQASRQARVFTPTSILPAHSLTQASHHGPVFKSMHADMPSKSCQTTGHFRVKKQPPLPPLPHSDPTPDHVSPISQAYPVTPLHSKKSSFLRQDVTINDVTTTSQYSPASQVSLSSNGTNSENTSMPMTPGYPGSFDDKRKSTFSTTSQDSLIRTSKVSKSRDLELKRIYRQSGLDALDMAFWTGDGFYSDDDDDVNSGEYTDRLATISRPTIHLPNLSDQNMDDGRNMKNVFAPMLDKPLPPSTTEASYKHDEHIEEAFIDEYLHLFDSEPEESCDVASLAVTSERSHYEDDEMLRASKRKSHLLSIYSRKSGSYEKRRLSPLHQAPNEDRLCSRCDQAVLGPAMRSSNGAFSGLYHPDCIRCASCHQKLPDSDIFVYKDEVYCRQHYHLQSGSICKGCGRGITGVYRKTSGNAVFHPSCLVCAFSSHLGRCGVLLDDYYLIDHRMYCEGHARSIIKDHGVRRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSU9</accession>
    <name>A8PSU9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732545.1">
        <property type="nucleotide sequence ID" value="XM_001732493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSU9"/>
    <dbReference type="FunCoup" id="A8PSU9">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSU9"/>
    <dbReference type="GeneID" id="5856851"/>
    <dbReference type="KEGG" id="mgl:MGL_0320"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0320"/>
    <dbReference type="InParanoid" id="A8PSU9"/>
    <dbReference type="OMA" id="NEAAMDM"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06106">
        <property type="entry name" value="ScCit3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="475" mass="51574" checksum="023BFFC5159C04F4" modified="2008-01-15" version="1">MLTLTIPRVALRSATAPRQFAAAAAAASTVRFASTKTLTEAVSETVPAKREQLAKLKAEHAETKLGDSTVGHLLGGMRGLKCMLWEGSVLDAESGITFHGKSIPQCQKELPSAKDIGRPGKEMLPESMLWLLLTGKVPTVEEAKGLSQDLVSRAKLPNYIEKLIDTFPKSLHPMTQFSTAVAALNHDSKFAAAYNAGVKKTEFWQPTLEDSLDLIARLPAVAARIYYNVFGKGDGKQNVDPSMDLAENFTHMLGYGDKEGLVDYMRLYISVHGDHEGGNVSAHTAHLVGSALSDPYLAYSAALNGLAGPLHGLANQEVLNWILELEKEVGSDPSDQQIIDSLWSTLKSGRVVPGYGHAVLRQPDPRFTALSGYCDTRPELQKSPTVKLVQRLSHLAPPVLTEHGKTKNPFPNVDAGSGAPLYTYGLDEFKFYTVLFGVSRAFGALPQLVYDRMLGLPIERPKSLSMDALEALLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT14</accession>
    <name>A8PT14_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0351</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732576.1">
        <property type="nucleotide sequence ID" value="XM_001732524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT14"/>
    <dbReference type="FunCoup" id="A8PT14">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT14"/>
    <dbReference type="GeneID" id="5856882"/>
    <dbReference type="KEGG" id="mgl:MGL_0351"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0351"/>
    <dbReference type="InParanoid" id="A8PT14"/>
    <dbReference type="OMA" id="AGDTYME"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="14">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP45362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="169" mass="17794" checksum="09B731933C5AFDA7" modified="2008-01-15" version="1">MVVDQEKLAKLQSAVRTGGKGAPRRKVVKKPKGAVAGGEDPKLQAALKKLAVQPLTGIEEVNMFKADGNVLHIEAPKVHGAVASNTVVVHGKAQSKELTELVPGILSQLGPESLASLRKLAESYQALSQQQESAQKGADAEGVPEVSGNFDEVEQQEKAPASTEVDQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT49</accession>
    <name>A8PT49_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0367</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732592.1">
        <property type="nucleotide sequence ID" value="XM_001732540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT49"/>
    <dbReference type="STRING" id="425265.A8PT49"/>
    <dbReference type="GeneID" id="5856898"/>
    <dbReference type="KEGG" id="mgl:MGL_0367"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0367"/>
    <dbReference type="InParanoid" id="A8PT49"/>
    <dbReference type="OMA" id="QAKPEYC"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="377"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="528"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="459"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="650" mass="73481" checksum="BCAD9F45FB5794E2" modified="2008-01-15" version="1">MSLMGELAQILRMDHGNNTSAALAWLHAHGIDALFSTTIEEDAGLSPHFATPHVAPGGLGLSSPHMYKDNDAMAFYRRILSDALQALPPLHRWHMPTIAPVSSGDRERLVEQVLDFETRLAHIHPAIPASLADPLSTYHAMTTRELEFMAPGIRWQTYMHELSPSMLPHKVIVANTRYMVQLSELVQSTPTLTLHTYMYWSVIRDAGRYLGPHVPLGSPARQLHNFNAGLAYDATHPQVSTCVASVTAALGYMAGRFFVEQAWDAQSQNAAMELVTSIRSAWHHSLSRISWLDAKTRERAQAKVQNLALNIGYPKRQPDSNDAEAVKKWYEDLPVASSYFLNEMASRMYRTRLAWMRLGGQVNSGGFGSLVTTDAEAEYHPIRHEAVFPAGLLQPPYFDREWPMYLQYGAAGTKVSHTLSHAFGPPGRFYDRNGILFDWWTPQTAHAYEEYVRCVETQAKQDRKEQKRLRKERKRQQKQQRHQERNEEKRKIRDDVHRQSISLQQPYVVHASPSTLRSTSVPRMLRNASAAETVADVHSLARSYEAWLDQLQKGDLAVYYRNLRLPGLQDYTHKQLFFIAFGSTWARSVLSGRASAQPGYRHQTDAHAPAAVKARVNAALVNFAPFADAFHCSPDKHAMARRTEERCDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTA2</accession>
    <name>A8PTA2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732617.1">
        <property type="nucleotide sequence ID" value="XM_001732565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTA2"/>
    <dbReference type="STRING" id="425265.A8PTA2"/>
    <dbReference type="GeneID" id="5856923"/>
    <dbReference type="KEGG" id="mgl:MGL_0392"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0392"/>
    <dbReference type="InParanoid" id="A8PTA2"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.17, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="76638" checksum="F6FE839F554E113D" modified="2008-01-15" version="1">MAIVSRRASTVLLRLFALFLVGTVIVLMLVRSHFRVDRSAYVLETELGTWDEIRASKRPAVLDHEHVMASSPPDLLPPEKVPRIIHQTWKTDMLPAKWASVREECAKMMPDYEYMLWTDQSSREFIEREYSWFLPTFDSYPYNIQRADAIRYFVLHKFGGVYMDLDIGCRRRLDPLLRFDVIVPKTIPVGVSNDLMFAVPGHPYLDLLIHSLSTFNHYFFTHYATVMFSTGPMFVSAMYRVFVQRNGIVQPSSPSALDRGFEGVRVLPKSLYGKNLSPSDAPDSFFIHMYGSSWHANDAGPLIFLRKYGYLLLFIGMLIVVIGMRRACLVALAHVLKLVTSFASSLGSHAGFRADSNRGSSYISLSTTASSSTPMGSKRRELPPSSHFAPIPSTDWFVSSRPSDVEAKIAPSPVHGTTPPVPTFSMNDSPSVYEPSGMLHLPSEPVIKSASQISRSSSPLPQPPLATSANVNARENVDALGHASTHMNSSDATVEPSFQRRNSDTNAPLPTYYVGNSVPSSNRFSLSDGGARSPSMPSTGRSNPLKRLSSSTMQTLSTLLPPPMRRSARSSHSDPDEASESLLSLGVDSADGLTRTISRQSEDYRSEWDSLVQDMSESTLRSPTLGPAVSPTPQLIEMPDAASSNSKMNVSGLLRRPHPADPFRTATPGVSAGPTDADLNPSQYPYSSHPSYLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTP6</accession>
    <name>A8PTP6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732683.1">
        <property type="nucleotide sequence ID" value="XM_001732631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTP6"/>
    <dbReference type="FunCoup" id="A8PTP6">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTP6"/>
    <dbReference type="MEROPS" id="T03.011"/>
    <dbReference type="GeneID" id="5856989"/>
    <dbReference type="KEGG" id="mgl:MGL_0458"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0458"/>
    <dbReference type="InParanoid" id="A8PTP6"/>
    <dbReference type="OMA" id="GFMLVHL"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="393"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="444"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="585" mass="64636" checksum="8784651C71683B84" modified="2008-01-15" version="1">MRVPSVYDRPGDDVPVYMRAESQGYEPYYNTTGSHGAVSSELDICSNVGVYLLSKGGSAADAAIGTASCIGAVDTFHSGIGGGGFALVKTQGNDPVVLDYREKAPRAAHRDMFVGLPQNASLYGGLAVAVPGEVRGWEQLHKMYGRLPWSELLEPVITITRHGFKIPTQLYDRLDTAKDILCNTRRLAPVYCPDGRLVQAGEHIRLEALSRTYEQIAQYGPNAFYGGDIARRTVAAVREAGGIMTMDDLRDFRVLIREARSITYRDQYRVWSSPMPSSGSVVLAALKTMEHFADEPYAPEHVLHTHRLIEATKYAYGERGQLGDPAFVRHVPAMEDRMVSDARAAWRRRNIRDSHVQPIDAYDPQHLYMAEDRGTSHFNVIDAQGMSIALTTTINGIWGSDVLTEDGILLNNDMDDFASPDRSNQFGYAPAEANFIEPGKRPLSSMSPLIVENLRTGDLELLMGSAGGSRIITANLQLVYAFLSHHGQKRIDHFIARPRWHDQLVPPITMFEYAVPATMIPNFVGYNNATIAELAAKGHEPVYYAPGFSNAQAIQCMHRDGRTDGQPWLLAATEIRQREARGAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU10</accession>
    <name>A8PU10_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732735.1">
        <property type="nucleotide sequence ID" value="XM_001732683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU10"/>
    <dbReference type="FunCoup" id="A8PU10">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PU10"/>
    <dbReference type="GeneID" id="5857041"/>
    <dbReference type="KEGG" id="mgl:MGL_0510"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0510"/>
    <dbReference type="InParanoid" id="A8PU10"/>
    <dbReference type="OMA" id="WKAMSAT"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="171" mass="20143" checksum="03B01D0819B1BE07" modified="2008-01-15" version="1">MERLKDIKEKPEFRKANKDGNSVFDIKMAASTIGSEWKSLSSSERDHFDKLYEKHVTQYQKDLEAWKESLTPDDIQRQNQFFAYQRKIGKKTVPRNIPVPKQLKRPLSAFFLFTQHLRETSNTSMPVTEFARHAGAKWKAMSATEKEQFEESARASKEEYQRRVEEFKASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUK6</accession>
    <name>A8PUK6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0707</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732114.1">
        <property type="nucleotide sequence ID" value="XM_001732062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUK6"/>
    <dbReference type="STRING" id="425265.A8PUK6"/>
    <dbReference type="GeneID" id="5856420"/>
    <dbReference type="KEGG" id="mgl:MGL_0707"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0707"/>
    <dbReference type="InParanoid" id="A8PUK6"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP44900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="110" mass="12708" checksum="38AC6C9A29ABF276" modified="2008-01-15" version="1">MLGDPSREMDFISATLDQDSKNYHTWAYRQWVLAHFGGLGPRDVKVEAAGAGQYPQLWEADINYADSMIQKDVRNNSAFNHRWFCIFGRAMQGRSELPPDMEPKRDDEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUP5</accession>
    <name>A8PUP5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732145.1">
        <property type="nucleotide sequence ID" value="XM_001732093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUP5"/>
    <dbReference type="STRING" id="425265.A8PUP5"/>
    <dbReference type="GeneID" id="5856451"/>
    <dbReference type="KEGG" id="mgl:MGL_0738"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0738"/>
    <dbReference type="InParanoid" id="A8PUP5"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="298" mass="31996" checksum="9999BE78C0AD6FEE" modified="2008-01-15" version="1">MSYMSSPSIVANDTESSTASLSVPRLSFNLTSSAESTTQLSSLMNGMATAGVHDFSKRPTSSMQVPQTSLASSTLSDLSLAAFVESLYTLEIAPSDGLTQSMLDGQTFLNESKVLRDDVSESSLSSSYPISNDVVPMKLSESGRDQTEYAKSAFLEDQLAFSVPSDMRWWNTALSLPLPIEKNFSTSSPQVNTFPSQSNHDSKPLAFDTGLDPSLSSICEPVSAASCCSKSRSATLGSAPTTHMGVPTPAGRIQLLHIFLEYIFHTSCVRPPIPQIIDRTAQTSIFAGKSPLCAEPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUU9</accession>
    <name>A8PUU9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732184.1">
        <property type="nucleotide sequence ID" value="XM_001732132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUU9"/>
    <dbReference type="FunCoup" id="A8PUU9">
        <property type="interactions" value="539"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUU9"/>
    <dbReference type="GeneID" id="5856490"/>
    <dbReference type="KEGG" id="mgl:MGL_0777"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0777"/>
    <dbReference type="InParanoid" id="A8PUU9"/>
    <dbReference type="OMA" id="THYTLGY"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="490" mass="54464" checksum="A23E9D6DB2E03F22" modified="2008-01-15" version="1">MLVTCMRLTRSIFLVYAGLFFLTSLSACIAAATEWTQDSFSKIMELGGAVGLLNLEIKATPAEIGTNGVATYLLYLTKYEHEHLSMLTASLVQEDDDSQELDLEITPLGALEFDHDTIQYAIDVPMEKVKAVNLLVNAVFLHITSPLPKELEQGEHQMLLWNGDAEPRTPYATSSASVSIRTPDPIITIDSSVGSKRNDNTVEFGPFNDVRAYTLESQPVAQGRVHFTYSRPVIAFVDYKRHVEVSHWGDNMATQDSILLRNVGPKLKGHFSRSLHMINMHMNPLAERVSQVQSLPLYLPSGAKDVYFVDATGNVSTSSLSPTPKMLGMPRRLDIRPRFPVLGGWNYSFTVGWNERMSQHGIARWNPAKPWRTRIAVPFLISPKTAAIDVANLTIALPEGATDIQVMLPFQVDSMETSTYPTYLDTVGRPIVSISRAKCSFMNSKVVFVEYTLPLSSYARKPLCVALAVLLVFFASAFVSRQVTPTQHMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVG6</accession>
    <name>A8PVG6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731591.1">
        <property type="nucleotide sequence ID" value="XM_001731539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVG6"/>
    <dbReference type="GeneID" id="5855897"/>
    <dbReference type="KEGG" id="mgl:MGL_0859"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0859"/>
    <dbReference type="InParanoid" id="A8PVG6"/>
    <dbReference type="OMA" id="CTNAGKR"/>
    <dbReference type="OrthoDB" id="20835at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="191" mass="20755" checksum="F09EF5B6E3761BBF" modified="2008-01-15" version="1">MSELDDIFSSVSKKVNPNPSKKRKNLQDTSSTKASLAQGDASSELRGAKKSKALKHAPSATSETGSSFHDVKTEKKLKKKQANRNAMEADDSNAGQAPTTAKKARAVPIVVHDETTTKVKKKPAIPRPQDDDDAAFADSRGQDRTYTMGCTNAGKRTEEGFRVFTEDELKLNKGGGMCDFCSDDRYTIVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVJ3</accession>
    <name>A8PVJ3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731618.1">
        <property type="nucleotide sequence ID" value="XM_001731566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVJ3"/>
    <dbReference type="STRING" id="425265.A8PVJ3"/>
    <dbReference type="GeneID" id="5855924"/>
    <dbReference type="KEGG" id="mgl:MGL_0886"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0886"/>
    <dbReference type="InParanoid" id="A8PVJ3"/>
    <dbReference type="OrthoDB" id="2550943at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="343" mass="38961" checksum="A93C0AA3891F18AC" modified="2008-01-15" version="1">MLMEQKKYHKPIHWNQLWCFTPDQGASVSSLPFTPSSVPDPLTEYALTQGRWSRLSGMGPASLSMLCHLSDPSTLDPVATLAPGLDHGVSSLNQAWIDGPWEPRLSLAFGHVLWKDLPRMTQPLTTPMHVPAYFVESELPNTAEQTPIIPGWSELLMDELEFERIYYRRTTSSDPYPVDLVVSVAIYPNRVVPERSWWQCEAHAPILCPYAPLDACLTVKYKAPANLQGTSLSSILSPMNYSDKFSNIEEFCTAFPTETTLNTNPNDEWRIWRRERVVQRSSTYFHADHTSELVLVREAVRRNSMSHFQHITRLESSNWSSDYIGVLSSLLRTSYPSLGRSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVK2</accession>
    <name>A8PVK2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731624.1">
        <property type="nucleotide sequence ID" value="XM_001731572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVK2"/>
    <dbReference type="STRING" id="425265.A8PVK2"/>
    <dbReference type="GeneID" id="5855930"/>
    <dbReference type="KEGG" id="mgl:MGL_0892"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0892"/>
    <dbReference type="InParanoid" id="A8PVK2"/>
    <dbReference type="OMA" id="PICAYEL"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="82"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="427" mass="46155" checksum="578270F61A788EDF" modified="2008-01-15" version="1">MHLDVQPLLHDTCAVLQAELGNIPLSEEWVAECIAHLCARDASLLSHTSLLHHSVRAQLMASDLVQSMDHASLTCIDKSLHAFVQIVGVMDVGVPAQALHDVWVARQSEPTTPYPRGMLRLELSDGYISTPIVAYEYERIPSLSLDTCLGTKLLLLHPMYEQDALLLTPSTVRVLGGTVPEMDSLAELAQRIGSALGKILPRGGVEQQRQQLLKSYPSQPSTLSSQLEKQRHQPLAGHQPEHTPVSKPQSFDLLQPPLPEPTDTASNKHVSGDQGIDDDNDDDDDDVWLMDAEQVMQQVEHANQPQPQLATSSSTTQRSLSCQAHQTSSLLQRLESSQLASTTPSSSLPSSSPPSMSLPYHTHIPSTSNPPTLIIPKRGTPTTSSQPTSIDLVSSDAEDTPVTASTPATASSVAPQTYITISSDSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVR2</accession>
    <name>A8PVR2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731667.1">
        <property type="nucleotide sequence ID" value="XM_001731615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVR2"/>
    <dbReference type="FunCoup" id="A8PVR2">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVR2"/>
    <dbReference type="GeneID" id="5855972"/>
    <dbReference type="KEGG" id="mgl:MGL_0935"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0935"/>
    <dbReference type="InParanoid" id="A8PVR2"/>
    <dbReference type="OMA" id="ACKEIEY"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000636">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="595" mass="65139" checksum="D9E45D17609FB07C" modified="2008-01-15" version="1">MSLAEPVAPAIMTPVSSQNEPTIAGDSSALPIASPAALSYFAAHPRRPQVYFGDYLLLQTLGEGEFGKVKLGVHRQYGEETAIKLIKRERVAAAEAEEQQQQHTHADGSKMSKVEREISVLKLLRHPNIVHLYEVIESERYIGIVLEYGAGGELFDYILAQKCLKERDACRLFAQLISGVSYLHRKKIIHRDLKLENLLLDKNRNVIITDFGFANNFSARSNDLMATSCGSPCYAAPELVVQDGMYVGAAVDVWSCGVILYAMLAGYLPFDDDPANPDGDNINMLYKYIMATPLSFPEYITAEPRSLLSRMLVPDPTKRATLEEVMSHSWLAPYRDLFRFSVDELESAAIEQQAKKRQAYRDQMVQQQRLIEKQYERSHHQDSVNNVPAMPHSQSTPAVPEPSEAVGSVPASATVATMPVLPETPLVASAAPTPPVVPTPAPVPVASEADAAVAKSVPRVETPASGVPTKAEFAMPQVPKMESTAAVLPTKSETAAPKRKIDTDEPKTRPSTKPRILSNELSDPFATMAKEVANSSRKSSRASDTSPLFKAVDARAESPWTWNMPKADTRVSSTEVPVPAAKPETRSRRAARIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVS6</accession>
    <name>A8PVS6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731677.1">
        <property type="nucleotide sequence ID" value="XM_001731625.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PVS6">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVS6"/>
    <dbReference type="GeneID" id="5855982"/>
    <dbReference type="KEGG" id="mgl:MGL_0945"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0945"/>
    <dbReference type="InParanoid" id="A8PVS6"/>
    <dbReference type="OMA" id="VLKSPKW"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="693"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="976"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1215"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1428" mass="158361" checksum="05C7E61E2F1F0F4D" modified="2008-01-15" version="1">MKHPSPSPSLSTSASAQRRGITDGDVYVFALQTAYLAFLLRRDQRAIPPAVPPKCRPESMSLPSMSSSRSSSGSSSSRADRPSLADRIRELRLSPAIPATSNSNSASSSTTMRFPDKFLRKLTERMERIAMGRDPFFHQPAFRQTIGSFYGVLVDEATQKRLKESRNLESVLLMFISSTQTSVKKRIVNEADARQEIEIQFDLFIRVVHECLRAMPSASRELLEHLSAYKGNRLCPSDLSSGSSIPTIPSRRSVDAASSSSSSLPSAFTSSTSTVPAASKALLSDSDPAKSDLIVATGKLFDVEEWQLQLDVQSVSQTCSLPDGIVDLKRCIYQIHAQTPWPGCPDDFLTPDAYRQWRSQELTQLSQLVAELCQARPDLLTASSTSDSSSRRKASSDMGRLESFPASSFSMAELTKDVGGSDDQPDMFTYIPPDPCAAYLRLLERCIDRDLDAIRHKAADEDVSLTILSPIHTQLLSTCARRWRVSPAYEKLARLRVCRTKFDAGEIPFECLVDAMVQLELYIDKELPVSMWRSADRIALAKWMQWLSDSLLRVVYSHMSKLDTSMTDECASSIRMIQRAQSLSPGEISVNTAPLEEAMRKAAMHAYAAEAQSVFRAHSDLLRGFLELHTWVERQIKAQSLRFSTPRILGFVPADQVAIGLVPMYLGDLASVHEAIVLQVRQSQDIARVNDALDLFQQIRALMRHCESDVRSAPSTSGTAGGMHLDFDVCAFFRAFVEMWISFSEKRASQWVHGAIQNDSFEPVDAANAMHSSSVQDMLEALQQPIVYVQSLDWPNEFQQAEFLTSLSRAFARLVEQYCHEVADRYMADMSQQQRELQAPAPASHGPPSSPTTQSGAAQSSPDRSGKDEGPPSRAMGLTLPPKQAAWVARAKQTLQSDFRERWGRGESHHVPPPPFVLQPHSCVMLNNMEAARQLLDTLYQRIDADKQADIVQRHARDAGSARLPPSQAPVAATTDPDESGASTSSNHVPSPYLFSVKVVQAELPPSARASSRLDTFVTLSDDRGERLAKTRTIFDSCSPRWDEVVDLPLASAQWISATMWHRLPQGDPLLFGRATVRLDPQLFADVNTHDVWLDLDRTGGKLLLRVSMEDSQDGILFIFGRAFRIVKRTEAEMTRALVDHISLYMRRILSRPVLASLVRGGRMDRALGNVRALYASALAQANGAAPGLPLLPQLHLPASAPQRRPPPLTDQEIEAAIVPLLDYFEETLGTLHSSLTPTQAQLVLTRVWKEVLATLESLLVPPLSDAPSDMKQLSDKEVDIVFKWLSFLRSYFNAYDPETGVAHGLPLSILQGSKYRELLSYLLLHDQSTDALMIECVRGFQARLAASHSRSKSVLQQRSLGTIRQHKRAKQGAGDDTSLMSDMAMKILRMRPGTSDFLAQQLISLHSLQSPACVKPASLRRTQKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVU4</accession>
    <name>A8PVU4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731689.1">
        <property type="nucleotide sequence ID" value="XM_001731637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVU4"/>
    <dbReference type="FunCoup" id="A8PVU4">
        <property type="interactions" value="705"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVU4"/>
    <dbReference type="GeneID" id="5855994"/>
    <dbReference type="KEGG" id="mgl:MGL_0957"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0957"/>
    <dbReference type="InParanoid" id="A8PVU4"/>
    <dbReference type="OMA" id="SFEDYWE"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="176"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="385" mass="44176" checksum="BA6C49490F72878F" modified="2008-01-15" version="1">MGKDDYVATVLARTDVPNELRPYYEKFGELRDKRLWYQLTLQIEEFLRHPASQQRPLHIDLYEHFIRSFAQHVNPLRLASFGVIVSRQYEDASEAMAFLQKLAGESDHPDTQDAHVLLTMEAAHFQLLLNDLNGTKSAMDRCAKLLDTFESVEPVVHASYYRVCGNYHKAKAEYADYYRNYLLFLACIHVDADMSKGEQVQCAHDLSISALLGDTIYNFGELLLHPILTTLQGSDFAWISDLLYAFNAGDMGRFEALLPRLPSEPILYAHVPFLRQKICLMALIESIFHRPTYDRTLSFKTIASETRIPVDEVEHLVMKALCLGLIRGSIDQVDQLVHITWVQPRVLDTAQTEALLRRLSDWSDHVEQVAEFVQKQSPELFVHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVZ4</accession>
    <name>A8PVZ4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731723.1">
        <property type="nucleotide sequence ID" value="XM_001731671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVZ4"/>
    <dbReference type="FunCoup" id="A8PVZ4">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVZ4"/>
    <dbReference type="GeneID" id="5856028"/>
    <dbReference type="KEGG" id="mgl:MGL_0991"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0991"/>
    <dbReference type="InParanoid" id="A8PVZ4"/>
    <dbReference type="OMA" id="MKNMGGK"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00064996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="97" mass="11024" checksum="84C7CDB79DA9F124" modified="2008-01-15" version="1">MPKQPTPKVTTGTRRTKAKKDPAAPKRPLSAYMFFSQDWRDASKPRTLTQDSVCDVGRLLGTKWKEMSDEEKKPYVEMASKDKERAESEKAAYANKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWA4</accession>
    <name>A8PWA4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731789.1">
        <property type="nucleotide sequence ID" value="XM_001731737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWA4"/>
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        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
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        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
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        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
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        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
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    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="41" mass="4723" checksum="4C5B230FB78CD946" modified="2008-01-15" version="1">MVSSLRRVNRKAHFDAPGHIRRKIMSAPVSKELRSQHGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWR9</accession>
    <name>A8PWR9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MGL_1196</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_001731876.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN PAN1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 17" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="183"/>
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    </feature>
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        <location>
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        <location>
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    </feature>
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        <location>
            <begin position="994"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00015110"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00020728"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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        <source>
            <dbReference type="PROSITE" id="PS50031"/>
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    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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        <source>
            <dbReference type="PROSITE" id="PS51082"/>
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        <source>
            <dbReference type="EMBL" id="EDP44714.1"/>
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    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1062" mass="116777" checksum="E5E9D251BFF61C05" modified="2008-01-15" version="1">MTGGMPMQMQSTGMPMGIMSNASFIQRPPAPPPPPPNMMTPMSSGVRPIMGQPTGMSPMLVQSTGMPPMMNQSTGLSPMMGQPTGMSPMMSQPTGMSPMMGQPTGLPLAAQTTGAFSDPRMRLMYTQFLPAAQPYSGVPTSNNMNFHLGSLQPAQFQSKLQTLTQQQPERARNQIPWTMSKEERKSYDSIFRAWDAKRTGWINGDVAKELFGQSGLSREQLLQIWHLSDSENRGKLNIAEFHIAMALIYRALNGNEIPQELPLELIPSSTRDLSDSVDFLKDLLKQDTSVRHSTALNLAEPGSNKDIKYKETRSFYRNPIEREETSRPTDAVAYKHQESDSAGYRSRSRYLDRREVRFDGQSAAEGLGEMKRQLEKTQRMLERTDLRDEEDHDLQNEMEDVRYAIRRLQDDIEYYNRREGPHAGDQRRKAERTLMQLLHERLPQLEKRLQRRQTRDQQKDLEASRQRDARNNDKYAHLREPMSSSASLQASPLASQATSVSPTTLTTEPSDNNTRSLASTSTTASATAAPPKLSGPEREAWIRSEAQRRVQERMRMLGVGGSVEKTASVDASVEQRLAAERSEAEARAAQADKEAKEREEARKARMRENKQVPFASARSRAQPPPPPARSNRPATSQQAPSSSNTSAVPAPQPRRMTELEPKPEPEPKPEPEPEPEPEPEPEPEPEPEPEPEPEPEPESRSEPHSVSSNSTTNPFLRLQGKDSSKPEEKHGIPKHKLQAEQGPVSKPESFHASACRPNDEPSRSAIPMPSKVSPSLPPAQRATSSASTSSSSRGVHLPPSQDEDWEEEDDGDDEYPMSSRATRQHLAQQLFSGVVPTPEPATSVPEAPPAPPAPAAPPAPHTSAVTTSSAPSNLGGGMGDRNALLSQIRGGHALKKTATRDRSGALTAGSVLGSASPPRGLSTASVPEPDSSDDEEPERADPMYVHDTMVNVPGAYDLDMTNTATPTHSKSMEPQETLALPKEDESTALGFDTGRVLHFRSLYPFEGGEGMLTFEENQVFLVHPTLNGAPMEGDWTFGALLSNPSRKGLIPAAYVTCMEQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWS7</accession>
    <name>A8PWS7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1204</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731936.1">
        <property type="nucleotide sequence ID" value="XM_001731884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWS7"/>
    <dbReference type="FunCoup" id="A8PWS7">
        <property type="interactions" value="870"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWS7"/>
    <dbReference type="GeneID" id="5856241"/>
    <dbReference type="KEGG" id="mgl:MGL_1204"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1204"/>
    <dbReference type="InParanoid" id="A8PWS7"/>
    <dbReference type="OMA" id="MKVYPLY"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="90"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="559" mass="63421" checksum="8494ACE24691C9FA" modified="2008-01-15" version="1">MTERGSTFLKYMTDDEAHERTLATDILMGLLKDVAKRRPDLKIVVMSATLDALKFQKYFNNAPLLKVPGRTFPVEVFYTQEPEKDYVEAAIRTVLMIHQAEDPGDILVFLTGEDEIEDACRKIRTESERLLEEEPDLCGPLKVVPLYSSLPPAQQQRIFDPAPAPVRVNGPMGRKVVVSTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCYRLYTERDWASELIEQTYPEILRSNLANTVLELKKLGIDNLVTFDYMDPPAPETVMRALELLNYLGAFDDHGNLTPLGEIMAEFPLDPQLAKMLIVSPEFKCSNEILSIAAMLSVPNVFVRPSQASQRQAADAARAEFAHPDGDHLTLLNVYHAYKTYCSDMASGSDWCWQNYLSHRSLIQADNVRQQLQRTMERFDLDLVSLPFEDKRYYVNIRQAIACGFFMQVAHKSTGGGSRGAYTTVKDNQIVTPHPSTTLDHMPEFVVYHEFVLTSRNFIRTVTEVRPEWLLEFAPSYYDPRTLDGEIKRVFQSLLARRRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWT4</accession>
    <name>A8PWT4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731942.1">
        <property type="nucleotide sequence ID" value="XM_001731890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWT4"/>
    <dbReference type="GeneID" id="5856247"/>
    <dbReference type="KEGG" id="mgl:MGL_1210"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1210"/>
    <dbReference type="InParanoid" id="A8PWT4"/>
    <dbReference type="OMA" id="ETWAFAN"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="6">
        <location>
            <begin position="178"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="624" mass="69065" checksum="3F8A6F41AAB20B2E" modified="2008-01-15" version="1">MSSRLGPVLRRRDMVLGRAANRGRHMSDDTAYHREEDHDRKWLRELELERQQERERSHRRAHPQMTNSMVSGRAKPVQFVQAHAGKGAVFNYSSRHRRPEADKKTLQDPEILARRNRAPGKPNLPFPEQHTFSLPSSSFNASSWVSSGVAPPLAGRSAAGIGEGWVGMKIQHKPTALIMPGQGSQYVTMARDLYESFATARRVWEEAEECITAFIMARPLDNMHPDPLRTAFEAHLARDQALEESVRSAPRSLKPGWLCDLVFRGSQLELTRSENAMPAILTVTLSFLAVLRQEFEIDFVKDHMSWIAGHGSGIYAALVATGAIEPMDALRAMRYRGLAAMNCLMTHPVLFPDGCEPPASMYETWAFANVSSGKGSNLVLDEEEAQSPDDTKYTDWRGTQVSAIVVRPGQLERALNEVQSVQAEIHAGRVPGIARDEFVETSHVNSQLQIVLAGTTVGVNYACDRLRFKGIGAHAVNLPMSGPYNTSFVETGSRAFAGLVDVMPLHEPCRDVKVVSSVDGRIFDNVEDIRDDLRVALSTPVRWLNSIDTLVKEGARRFVCLGPSRAIAQQLSRELALRERAQGRDGLAGNCADDPESLAFEVWSVATAEGVEQLVSSLRSLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX31</accession>
    <name>A8PX31_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732039.1">
        <property type="nucleotide sequence ID" value="XM_001731987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX31"/>
    <dbReference type="STRING" id="425265.A8PX31"/>
    <dbReference type="GeneID" id="5856344"/>
    <dbReference type="KEGG" id="mgl:MGL_1307"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1307"/>
    <dbReference type="InParanoid" id="A8PX31"/>
    <dbReference type="OMA" id="HFEANHA"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="212"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="535" mass="61811" checksum="DB4B8E24A1268ED9" modified="2008-01-15" version="1">MATSPRHTLHNADAVMPFDMQNTHLDSNVSNSTSGNLNYKPYQKRKSPFRTVSCSESGGGNFNHRGDQVIANGSKDGSPKITTQKPVQSMVSLQMGNNTQNFPPKHYYRTLYQPKGVSCHRTDEFKVLRAKKSNAMDLDDQRMERRLDKLLYIYSPEFSSFKLNEFSSEHSSLLLRGNQVWDMFRSRHEQRLHRLQAIRRPAEQNVVKWQEDAEQPNCCICQTPFSLAVRRHHCRLCGRLICSSPHLPNLLQPQEAEQLNLWEPCSSLMVCDASSRQFREFPVRPTMNASPDQWRAFEDDELFSIRFCKDCKTKIYRIMLRNRRKSTSTPELFYEKLILLEREIHEALPDFHEMIFGLQKNDTNMSLASSAQDSQALQSSAVQARKDLLARFMQYEELARKIASLPPTIDGINSPTQKRLQQAILARATLFLQKHVRFKHFRIAYSQQMFPLQNLPSSNPHKSKSLARVQTLRMPPDIQEQLQVLGTQEMLLMEYIESAQNARNLDDVNSLQANLNEIRSEIARLHEAQIDSVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX38</accession>
    <name>A8PX38_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiamine thiazole synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Thiazole biosynthetic enzyme</fullName>
            <ecNumber evidence="6">2.4.2.60</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">During the catalytic reaction, a sulfide is transferred from Cys-231 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THI4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731131.1">
        <property type="nucleotide sequence ID" value="XM_001731079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX38"/>
    <dbReference type="FunCoup" id="A8PX38">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX38"/>
    <dbReference type="GeneID" id="5855444"/>
    <dbReference type="KEGG" id="mgl:MGL_1314"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1314"/>
    <dbReference type="InParanoid" id="A8PX38"/>
    <dbReference type="OMA" id="MFPRIVV"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03158">
        <property type="entry name" value="THI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027495">
        <property type="entry name" value="Sti35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="124"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="309"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="6">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="347" mass="37099" checksum="F1D54C1E4A7DD632" modified="2008-01-15" version="1">MSPPALTCASQPALDKIWPRDSLKQHIATIQRRQTALKGVDAPTYVQRVPIVPGKEPVEDYDGNYVFADIKESHTSRAMISRYYKDMMDASVSDVVVIGAGSAGLTCAYKLAKSRPDLRITILEAGVAPGGGAWLGGQLQSAMVIRKPAHNLLVELDVPFDDEGAYVVVKHAALFTSTILSKLLAMPNVKLFNATCVEDLIIKKDPTGTQRVNGVVTNYTLVSMAHGLQSCMDPQTITAPIICSFAGHDGPFGAFTVKRLASAGLLNLGDMNPLNMNESEGLIVNNTREVFPGVVVGGMELSELDGHPRMGASFGGMLASGTKAAVEAARAYDRLEIDEGEVVSVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX77</accession>
    <name>A8PX77_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731170.1">
        <property type="nucleotide sequence ID" value="XM_001731118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX77"/>
    <dbReference type="STRING" id="425265.A8PX77"/>
    <dbReference type="GeneID" id="5855477"/>
    <dbReference type="KEGG" id="mgl:MGL_1353"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1353"/>
    <dbReference type="InParanoid" id="A8PX77"/>
    <dbReference type="OMA" id="ASEYNHV"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="147"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="266" mass="29625" checksum="69CD5858384E94DD" modified="2008-01-15" version="1">MTGRVRTDRGTSATMEEVQVWQVVRAQLRGLDSARSSSLSGYEKLLKASSDAKNMDALYAMVERYVQEEHRCIVGALEQIHVLIALRKASSGMAGTELRRRKRRTDEPAELEDIGTELKTKGSGSDMRKNRAPPKANDNTHWMRIKPQLPLQRGRKVAFCQTPEGNNVGEEEWILATVIECIQGDKTRYVVQDAEDEGPNGPKWNTTIHSIVPLPVNIDSLPSEDYAVGTRVLALYPDTSCFYWATVQGGGPNIHASVPRNKTHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXB8</accession>
    <name>A8PXB8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731211.1">
        <property type="nucleotide sequence ID" value="XM_001731159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXB8"/>
    <dbReference type="STRING" id="425265.A8PXB8"/>
    <dbReference type="GeneID" id="5855518"/>
    <dbReference type="KEGG" id="mgl:MGL_1394"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1394"/>
    <dbReference type="InParanoid" id="A8PXB8"/>
    <dbReference type="OMA" id="VMINIEL"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF153">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="4">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="3">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="446" mass="50930" checksum="21ACA039A6827DCB" modified="2008-01-15" version="1">MADSGDTVGDKRGFHALASHVWRKLKQIDLNPETAFKRKRPPPSSRRVMINIELPKEAYDKRGRVRRQWMFATNQVITAKYTVYNFVFKNLLEQFRRVANIFFLVLVILQFFPQFTTISPGLAMLPLLIVLFITMVKDGYEDIKRHQSDRTVNRQKTRVLSGHGYTNHNKTEGKSRSLLLMWQLAWRYVMPPWLVEKFSKKRKQQAVSMHDLGAHAPPGSPRPLSPDAAHGRFSSMSFDRPSTIGKSSHDEPRHSLSLSGHGASAYWRSRHWDDVKVGDIVCLRNNDPVPADIVICATSEDDGSCYVETKNLDGEINLKSRYAVQQLTDMRSPEACLDRQFDVEVEPQNTDMYRFSGCVNLYDEFDEEGNPLACPVTLNQVLLRGSALRNTEWVIGVVVMTGADSKIVLNSGDTPSKRSIMEYEMNKMVYVNPGHHRRHGRDLCDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXC3</accession>
    <name>A8PXC3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731216.1">
        <property type="nucleotide sequence ID" value="XM_001731164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXC3"/>
    <dbReference type="STRING" id="425265.A8PXC3"/>
    <dbReference type="GeneID" id="5855523"/>
    <dbReference type="KEGG" id="mgl:MGL_1399"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1399"/>
    <dbReference type="InParanoid" id="A8PXC3"/>
    <dbReference type="OMA" id="NAYWEIN"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727914" description="GH16 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41652" checksum="8D23DAD00F1446AA" modified="2008-01-15" version="1">MKVAVWGLLQLLSVSLVWGLGWKLDDSITGEDYFNKFNFYAGPDGADNMTHGMVNYVDMPNAKRLNLSYANGDNFVMRVDTTMEQPNGRPSVRLHSKKSYRDSVIILQVAHVPLGCAVWPAFWTVTDNTTQWPKGGEIDILENANDQYPYNLAAVHLNRTCLIENPKQTGTTIFNDCEAYANENSGCRIAMNGTSDATWGHKLNAKGGGTVAMQRDFSRDGKGVRMWFWENCDEPEELKKPGSSVNPDSWGTPAADFGLTQCSDQFDNHMIIFDITLCGDWAEDTYSDTTCPSQYKSCGYQVGKLGNTFEDAYWDVKTLFIYTPDENASSSTTSNTKRSSEGTCALGKPPSGSAGAHLPNLTLLISLFVLTAMIILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXF6</accession>
    <name>A8PXF6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731249.1">
        <property type="nucleotide sequence ID" value="XM_001731197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXF6"/>
    <dbReference type="STRING" id="425265.A8PXF6"/>
    <dbReference type="GeneID" id="5855556"/>
    <dbReference type="KEGG" id="mgl:MGL_1432"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1432"/>
    <dbReference type="InParanoid" id="A8PXF6"/>
    <dbReference type="OMA" id="GICHEAT"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34696" checksum="C4C72AA8D4696ABF" modified="2008-01-15" version="1">MSSQVLKCLSAARSEALRDAFEHFTHTASESLRIVYSTQPNWPLRCHASKLSSLANTTTASPLLRIAVLDSSFNPPTRAHAALASLPREQDIPFDAHLLIFSVRNADKGRGRAGDASPLERLEMMELLAYELETHMFNVAVALADEPLVFSKSSLVHANVKIDVPYQLCWLVGSDTITRVFHPRYYDSEMHFAACCRRFFGDEHSAMLCAERSSASVQGKAGLPNASLSSSAPASSKEAQSLLECPGPARDWYECGAISLRSLNPEDARHSSTAVRQFLRSAHESHMPRDQLAAQLGTMVPVALAEYLLSRHLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXK4</accession>
    <name>A8PXK4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear condensin complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1468</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731285.1">
        <property type="nucleotide sequence ID" value="XM_001731233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXK4"/>
    <dbReference type="FunCoup" id="A8PXK4">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXK4"/>
    <dbReference type="GeneID" id="5855592"/>
    <dbReference type="KEGG" id="mgl:MGL_1468"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1468"/>
    <dbReference type="InParanoid" id="A8PXK4"/>
    <dbReference type="OMA" id="NHQKNFV"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="8">
        <location>
            <begin position="392"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="657" mass="73479" checksum="3450AAE2BFF8E14F" modified="2008-01-15" version="1">MERLTDRESSVRVQAVIALARLQTDEDGTDEHTLRLLLHLLRHDMSADVRRAALFNIAPTPATLPFLLERLQDVDATNRRCVYLGSLKMLLDTQPLVERQDGHTVRETLGLGEVSLSEVIRIGLHERDLSVKKAARKLVAFWFEAVGNDILTLLDHLHVSRSANGEPAVLALLEDMADVRNQVAAWLTEQDTYWQTVTPAKALLARCFVLYCSTNGQERELEACLPVVTALAFRIQSEYDALNRILEQQAAEEMEEDMPAVQDDSALSRIFIVSEMLAIAMHCDYADEMGRQKMYMLVREMLGNAWLPAELVPRCLDVLLRLSSGQRDFLQMVVELVQALDAEMDEFGDDADTSVRQALSWHQRVAADGNQSQAMTLSPEQAANKAALDARRLLIVRSMLERIACSLQDDASLEGLIQELIVPTVQSRDAALREQGLVCLGLCSLLDAKTALVTFPLLLNQIQRASGSILARCVECLFDLTIVQGIDSLCAQSADVAAQNEFDGDREQGMRFARQQMIGFLLSLLEHDDSHVQTIAAEGMAKLMLTGVLVEDDVLKSLILTYMSPYLVDNAALRQCLSYFLPLFCSSHVRHQRMIQHVFCDVLSVLVSVYDDVQAPPKMISPSQVATQLLDWCHPAHLMYVCFYYTISTHTYQVDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXL2</accession>
    <name>A8PXL2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731290.1">
        <property type="nucleotide sequence ID" value="XM_001731238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXL2"/>
    <dbReference type="FunCoup" id="A8PXL2">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXL2"/>
    <dbReference type="GeneID" id="5855597"/>
    <dbReference type="KEGG" id="mgl:MGL_1473"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1473"/>
    <dbReference type="InParanoid" id="A8PXL2"/>
    <dbReference type="OMA" id="NTIDGHR"/>
    <dbReference type="OrthoDB" id="24745at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00755">
        <property type="entry name" value="RNase_P_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="233" mass="25482" checksum="7730389B792728C6" modified="2008-01-15" version="1">MVRFKNRWLLLTLAAEPPAIPDDYDHYIPFSHRAPNVNAYSITKAIRASLRDNFGDVSAGAYAGPLTCKYYSPKSGIGILRSSRDGVRQVWAATTLLNTIDGHRVRICVRSCGGTIRKVQRKAISIDKTCILRLEQARQKNKDAVRTASSEYHARSGQESMNASNAQGDADDLGVSIEEDDDMGVSIDEGGSDSFEDTSSNGADDLEGSFPVSDECKREIAESRSVIMSITRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXS2</accession>
    <name>A8PXS2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731330.1">
        <property type="nucleotide sequence ID" value="XM_001731278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXS2"/>
    <dbReference type="FunCoup" id="A8PXS2">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXS2"/>
    <dbReference type="GeneID" id="5855637"/>
    <dbReference type="KEGG" id="mgl:MGL_1513"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1513"/>
    <dbReference type="InParanoid" id="A8PXS2"/>
    <dbReference type="OMA" id="QENFWRR"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="207" mass="22871" checksum="C87D58171566D37F" modified="2008-01-15" version="1">MAWGPSRLMSPSSNVLARAFSTSARAYKAQGKRATQIAQQSGADHVAAYVPALASPPLTHGVHVATLQLTSNNAKTFELDFFADFAMRAAHALQIPTGGIAMLPIRTTLWTVPRGPFVHKKSQENFWRRVHRRSIKVYDASDITVDRWLHFLRAHEMPGVASKAQLFRRYPLGIGQHMQTAAVAEVDTSAEAVRAMAEDILRMHASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXW2</accession>
    <name>A8PXW2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1538</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731355.1">
        <property type="nucleotide sequence ID" value="XM_001731303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXW2"/>
    <dbReference type="STRING" id="425265.A8PXW2"/>
    <dbReference type="GeneID" id="5855662"/>
    <dbReference type="KEGG" id="mgl:MGL_1538"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1538"/>
    <dbReference type="InParanoid" id="A8PXW2"/>
    <dbReference type="OMA" id="EEIPRCT"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="14">
        <location>
            <begin position="59"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="316" mass="36037" checksum="9ED19411B978D378" modified="2008-01-15" version="1">MRDLIVYLDPTPVDPQTGVLGRFYQQLKTRILGDGACCLTCTASPLDHIGDKIIGRVMFERKARSKYDPVLQHWEPLEEEQVVREPTVVFVMTAEQVWDSMTNESLMTSLKANEPRSTLGPLQRFVLIIGLDALFRRIRAKKNRTYAEMIRQRIEGNMTAQVQMPDDQTREHMEQRLLQLQLRHQCHVVRVTQAEEAVEWVYSIACDISIRPYKQLESESVYHKVNKAASSNSFSAYRAMLEEIPRCTSNASAAITAKYPTLASLMQAYKQASSTEQAADLLTNLICDGRHRRLGSQLSRRIHLAFTTYDAKASVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXX6</accession>
    <name>A8PXX6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731364.1">
        <property type="nucleotide sequence ID" value="XM_001731312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXX6"/>
    <dbReference type="STRING" id="425265.A8PXX6"/>
    <dbReference type="GeneID" id="5855671"/>
    <dbReference type="KEGG" id="mgl:MGL_1547"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1547"/>
    <dbReference type="InParanoid" id="A8PXX6"/>
    <dbReference type="OrthoDB" id="2120038at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725387" evidence="1">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="107" mass="11932" checksum="E323616CD982F3A3" modified="2008-01-15" version="1">MDTGFNSRLWLLALFGLVGGLVAHRLSLKENQAGTSSGDNSGKPYLTELLEAWSTPSEQTRESNQEHLDLSIKKAESQLMIQDAQKPAAHRIRFLPYVSPRVFASLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY12</accession>
    <name>A8PY12_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731386.1">
        <property type="nucleotide sequence ID" value="XM_001731334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY12"/>
    <dbReference type="GeneID" id="5855693"/>
    <dbReference type="KEGG" id="mgl:MGL_1569"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1569"/>
    <dbReference type="InParanoid" id="A8PY12"/>
    <dbReference type="OrthoDB" id="2115177at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="8">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="556" mass="61171" checksum="F52B17E63A2AE038" modified="2008-01-15" version="1">MTFMQYAPCAHAENQNSNSGSINTNVLARNRTLYTSSVAYCGAPTTVFLKRLDLRYKGDEQQFDFDVQVSSTRGDEDFDIIFDLYVYGRKYITVHQDLCKIGNGELCPIPKYNFTGSSHIKVPDSFAAKVPNIVFDVPDIEALAMLKLYDQPTQNLSGCLQVQLSNAKTVDLPDITYGLAAFVAAAALASLVTTGWSHSLSSLQWRIVDIVTTIQLTPMVSMITMIVPRVIHVFSLRFSWIMGLIRIESIYESILDSRKSTGSDDVHLVFGQLMEAEYSRLANYYPASVLNANQSAEILDVNGISSLDLHTLQPRKLYAPNTGPGGELDPGGAGDNVVWAVSMNDFDQSGVFYYTESLNISPYSAFLIALVSWLLVVCIALCIGILVAGFVGFLSQAGPAAQSASLVLAVTQAHSSPCIRVRNTTASDSGVVPVRQFYLMALSLHCRSHVLRLGVPLVDYLRPAVCTGTPRRCRVSLLHKDLAVEYDVSRSPYWLYVASMEAPVLVVLVSHAWMQFPARLLRGHPSKAQLWAATICRSPHGRRFTSDRSLGLSTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYA9</accession>
    <name>A8PYA9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1626</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731443.1">
        <property type="nucleotide sequence ID" value="XM_001731391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYA9"/>
    <dbReference type="STRING" id="425265.A8PYA9"/>
    <dbReference type="GeneID" id="5855750"/>
    <dbReference type="KEGG" id="mgl:MGL_1626"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1626"/>
    <dbReference type="InParanoid" id="A8PYA9"/>
    <dbReference type="OMA" id="YTNENDR"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="552"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="586"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="662"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="696"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="813" mass="90166" checksum="1520B74DB4DFB78E" modified="2008-01-15" version="1">MSPQSRVQQGLGPRTPLRISTPAAFETPMSLPGLLGGGAECGPVNPLQQLGKRFGQDRGAQFDKFQHGPDAAPGRPTAFRSQVSAAGPADPAFFASGPVAPFHVDQLRESLPQVVPHEQWAPSQAVMETSFHRQQHTPVPVSSTSATPAWAQDFLHATRTSTKHTAVQPASNIHPVPAGAAAATVPRGMPPLASQFHRPLHAVPVMGQHLQDSLVSRAHNDDLAYVSQSTWDSAFTAIDAQTQQPNESAAIPSETQLDTMNADQLAQTAERLLNAVQHDSSEKFQQSEFLQLMRKLRDRVAEVRGDQIVDRDAKGKAKAHGPPSQADLDTMLQHATPYGSQRETQQENQHHGHAQTLIPDALADLDEFWREEDLAKERASSHPNTFLGDGGDVAARMLEDDAFSRQQHNQQDRGMNGDDLIAQEYNKWTSLGTNVPGASSEWQEAFDSDEHDQDFVGRAWLGKKGHGLPGAQNAEWAKLQSDWDEFVATPDGIKSHNRTHDPFPYETPAYRFHDANPYMANMTRNHAAHSPPGMLDTVLEHEAAVQEDPKDASKWYNLGLRQQENERETQAIAALHEALKIDPAMKEAWLALAVSYTNENDRDEALEALDRWIKVNDKYQAVVQSYQQARGRQGQDRHRQLANMLLAMARSRAQDISEPVDADVQVAMGVLFNASGEYSKAVDCFTTALHVRPDDWILYNRIGATLSNSGRSEESLQYYQQALTLRPDFARCHFNLSISCLNLKMYTEAAEHAYTALTLQQASEDDDMPGVQNNSLWEILRVSLDLMRRPDLARLCMTRDINQIHLDQIVGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYD0</accession>
    <name>A8PYD0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1638</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731455.1">
        <property type="nucleotide sequence ID" value="XM_001731403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYD0"/>
    <dbReference type="FunCoup" id="A8PYD0">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYD0"/>
    <dbReference type="GeneID" id="5855762"/>
    <dbReference type="KEGG" id="mgl:MGL_1638"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1638"/>
    <dbReference type="InParanoid" id="A8PYD0"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP44241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="465" mass="50467" checksum="BE2C951BC8B2E630" modified="2008-01-15" version="1">MSVLPEVSAPERRVPFQQRVMWTAIVLAIYLVSSQIPLYGIMSSDSSDPLFWMRVILASNRGTLMELGISPIVTSGMIIQLLASANLLQVDFSLREDRALYSGAQKLFALILSLGQATVYVLTGLYGPPSELGAGVCLLLILQLVVAGLIVILLDELLQKGYGLGSGISLFIATNVCETIVWKAFSPTTVNTGRGPEFEGAIVALFHLLFTWNNKSRALKEAFYRERLPNVSNLVATLAVFLIVIYLQGFRIEIPIKSTKFRGQQGSFPVKLFYTSNMPIMLVSALTSNYFIISQMLATRFPSNIFINLLGVWDRLDDNPQLHAVGGIAYYLSPPTSMGAVFRDPIHALIYIAFTLTFCGVFSKVWIEVSGSGPREIAKQLKDNQMVIAGHRDASMYKELKRVIPTAAAFGGALIGALSVVADLSGALGSGTGILLAVTIIYSYFEMGMKEASGISASPLADLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYR8</accession>
    <name>A8PYR8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1712</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731529.1">
        <property type="nucleotide sequence ID" value="XM_001731477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYR8"/>
    <dbReference type="STRING" id="425265.A8PYR8"/>
    <dbReference type="GeneID" id="5855836"/>
    <dbReference type="KEGG" id="mgl:MGL_1712"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1712"/>
    <dbReference type="InParanoid" id="A8PYR8"/>
    <dbReference type="OMA" id="VYLWLYL"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="12"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="184" mass="20812" checksum="9EE0AF1E930D5F18" modified="2008-01-15" version="1">MVSAQRFNLRSSQRILFFWLVFDALIHICLEGPFVYLSMHGRTVNASRGFFASVWQEYSLADSRWGVADPGIVAVELLTVVVKGPLALYTSWLVLKDNAKYHIWLCFLCLAELYGDYMTFVPEYFTNAAALDTQNPLHLWFYLVISNGAWVITPAYLLVKSTYALVRMADASSVPPPPPPKKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ73</accession>
    <name>A8PZ73_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730895.1">
        <property type="nucleotide sequence ID" value="XM_001730843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ73"/>
    <dbReference type="STRING" id="425265.A8PZ73"/>
    <dbReference type="GeneID" id="5855202"/>
    <dbReference type="KEGG" id="mgl:MGL_1894"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1894"/>
    <dbReference type="InParanoid" id="A8PZ73"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="361" mass="41307" checksum="42E9506822F93709" modified="2008-01-15" version="1">MDRRQGRALLEIVQRIYDTMWRPRAPIPQTEPLWEPRLSIGQSAVCPSAILARTWLQLGMPSLAEVYMAHIRRLSPSPPKNWDELLLDATITCAFRHVEQGKYEHAISSLVSKNTLYQITSLSLHQQWQDAIWYVMYVRARRQNHTATLRRLEQLCPGVHEWYEPIRSTEPTASAWLREAQNMIHARQPHQSLEVLMKALAASEAQQLFPMRRTCLAVLADTMIMSLGMHTEARALLDEIFPQVLADENAERRAYVHMVLGKYFLATKELVAARDSLRVAAQNYECLEAWKDQAMCLYLEASVSHLLQDTEAHVNAVQRHGEVQSRADEAHTASCPMPPVDALERLVCRMSERCQCSLVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZG4</accession>
    <name>A8PZG4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730918.1">
        <property type="nucleotide sequence ID" value="XM_001730866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZG4"/>
    <dbReference type="FunCoup" id="A8PZG4">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="GeneID" id="5855225"/>
    <dbReference type="KEGG" id="mgl:MGL_1917"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1917"/>
    <dbReference type="InParanoid" id="A8PZG4"/>
    <dbReference type="OMA" id="IKEEMKW"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="3">
        <location>
            <begin position="101"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="245" mass="27168" checksum="EBE7D680AD796CDB" modified="2008-01-15" version="1">MLGGLSMLRAGVLRVPGRLSSVRVIRSFPSSSVHTAVTRFASGASYGNVATASPVLTSARTFSSAPPPTPQQTVAPNLDANKPHAEHSDKHSVFRRLSFYQRFKTIMKLYGWWALGIYSLLSGIDLTLTFAGIHFLGGEHVEELEALLYKWIGPMLKKLKKEEEPKENTFFTYVKGWFTTEEKANEMEHLIARLSGEFVLAFAIHKTFLVPVRAGLTILITPGIVRWLIKRGLARPLKTTASTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZQ1</accession>
    <name>A8PZQ1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730940.1">
        <property type="nucleotide sequence ID" value="XM_001730888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZQ1"/>
    <dbReference type="FunCoup" id="A8PZQ1">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZQ1"/>
    <dbReference type="GeneID" id="5855247"/>
    <dbReference type="KEGG" id="mgl:MGL_1939"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1939"/>
    <dbReference type="InParanoid" id="A8PZQ1"/>
    <dbReference type="OMA" id="YFQGGNN"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="13"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="99" mass="10743" checksum="CC4A42D49BFBCF8E" modified="2008-01-15" version="1">MAPQTKTKKSSQDNINSKLQLVMKSGKVSLGLKSALKNMRSGKAKLIVISANTPPLRKSEIEYYAMLSKTGVHHYQGSNIALGTAAGKLFRVGYVSEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0J7</accession>
    <name>A8Q0J7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731044.1">
        <property type="nucleotide sequence ID" value="XM_001730992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0J7"/>
    <dbReference type="FunCoup" id="A8Q0J7">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0J7"/>
    <dbReference type="GeneID" id="5855351"/>
    <dbReference type="KEGG" id="mgl:MGL_2043"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2043"/>
    <dbReference type="InParanoid" id="A8Q0J7"/>
    <dbReference type="OMA" id="FPFHSEQ"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="54"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="404"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="783" mass="90272" checksum="60BC4A6FD020B74A" modified="2008-01-15" version="1">MVRKVRVPHISLEAQLQQLTLLSDVDTTTDNYEQLGPVIKNLDESHQQDEFLKQLREFVRKKDEEIEHVCNENHQDFVSAVDELLIVRSGTVNLKQRINELNQEIQSSGQALFSKKKDLIDKQRVVQNVDEAIETLQECQNVLEMTTLVEDLIAQQKFYSALRRLDEIANIHLKPIMHHEVAQLIRDTIPRTRERIRMEVLKQLKGWMFDVREKSGAVGRIALETMEARQQRWLHRSKKDPMLRLSSINSPIEQIVNERIEVNYLENDRVRVDFKPLYQCIHIYEVLDQREKLQANYQEDRKAQASLLLSRTLTMREGGQELISLLEDVVGYFVVECHVSYTSPPGFRPMSEVEDVWDSMSERVVDMITAGLRDCKNAKVFIEAKSAIQTFIRTLESFEFSVSRLNALVLSFFRRFAHLLRERFASDFQQAIREAQHQPMIVNNGDELAKVLSVCWLKPGEADQLKQLPFPLSLPFSQTYPLCCMDIRSLVEQYYSFSSGMTQYHQDIDLILTQSLDDLLIQQISINIRDTVEQSTNLSQIAQIIVNIEHFQLACSELERWLSESRTPNPGSRLALGASEHLSTTLEIAQKRIDSAMFVKLDQFLDLLEYDWMPIQSASMQRQPSSYLRDLIDWLSTMMESALVLLPKVAKDATFTSCFMHISNRLLNSALLDRQVKMINLAALTNLDVDITFVYQYAKSLNVHGIETVFGQVRQTLGVILSESVSEYALSQQARAQKFPQVQPVKVAAILEKLSRGYAHLGLHDLAANCTREQELVMRLNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0S5</accession>
    <name>A8Q0S5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731076.1">
        <property type="nucleotide sequence ID" value="XM_001731024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0S5"/>
    <dbReference type="STRING" id="425265.A8Q0S5"/>
    <dbReference type="GeneID" id="5855383"/>
    <dbReference type="KEGG" id="mgl:MGL_2075"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2075"/>
    <dbReference type="InParanoid" id="A8Q0S5"/>
    <dbReference type="OMA" id="IPINPIY"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="348"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49640" checksum="77C40FC61D30905A" modified="2008-01-15" version="1">MEHPVADSDLKMIFAHPMTLKSLREALSKLGRSFKLPNGQPSVWIINDADAVQAATTGELDFREALQDKDWPTERVNSTEDVSFIVYSSGTSGKPKGVMLTHDNLISNTETFNLVSRREGGPYQTAIGVLPFFHIFGLNILVLSSFLHGFRVVVVPRFDINVFCAAVQRFHANMSVVVPPILLALARHPDVDKYDMSSLTAVISGAAPLGRELCEEVQHRLPKLGLAQGYGLSETAPVLLRCIVDRHRQHLGSAGQIVPFNEIRLVNYDGKDVAYEQGSSGNPGELWVRGRSVMKGYLNNPDATNECMTPDGWFKTGDIAIVKDGFFYIVDRMKELIKYKGFQVPPAELEDMLLAHPNIADCAVIGLYKEDIATELPMAFVVPKKGVIDLVNSSQSEKDACGNEIANWLDSKVANHKKLRGGVVFIDEIPKSQSGKILRRVLREKANNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q120</accession>
    <name>A8Q120_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731115.1">
        <property type="nucleotide sequence ID" value="XM_001731063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q120"/>
    <dbReference type="FunCoup" id="A8Q120">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q120"/>
    <dbReference type="GeneID" id="5855422"/>
    <dbReference type="KEGG" id="mgl:MGL_2114"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2114"/>
    <dbReference type="InParanoid" id="A8Q120"/>
    <dbReference type="OMA" id="TPSKWWL"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="178" mass="19927" checksum="DE64DC4C24494F92" modified="2008-01-15" version="1">MPAYHSSYNDELNVRQVAGAAILPLNSKIRGPAPLPADPSRPDIVDEAIDLFRANSLFRNFEIKGAADRTLIYLILFISDCLSRIAAAPTTWTKNEAYKHLSSYAVDAFALPGDAQFPLSTLYSLPNSRADADALRQYLTQARQETVSRLLDKIYVDDVPSRWWLAFSKRKFMGKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1K9</accession>
    <name>A8Q1K9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1804</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730805.1">
        <property type="nucleotide sequence ID" value="XM_001730753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1K9"/>
    <dbReference type="STRING" id="425265.A8Q1K9"/>
    <dbReference type="GeneID" id="5855112"/>
    <dbReference type="KEGG" id="mgl:MGL_1804"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1804"/>
    <dbReference type="InParanoid" id="A8Q1K9"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF20">
        <property type="entry name" value="HIGH OSMOLARITY SIGNALING PROTEIN SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="252"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="311" mass="31705" checksum="070555EBA4FD0B38" modified="2008-01-15" version="1">MFGIGTLLSVLHTDFGIYSDHGDLEALGAGYLILAIGNLLCLIYFAIKYEMDHMACTGVQSSSMGRNNLMYTDNTMSGKGNASGMDGIIGTFSGSGLRNRNGGGNTFSGPDNSKMSENRAMDTIGDNNMYSSEAGLRSPNLGTPSALGADPLSGGYSQQPEDVSINMASNGSAARAGGNHGEPADASAATAAPASQSTTFASMVPNGGGVNGSNLAPPITTSNFGSAGVGAGAVGVDGSAPASSAPLETGMGSVQRAEALYSYKASEDDPTEISFTKGDILQIVDSSGKWWQAQRPNGELGIVPSNYLRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1P2</accession>
    <name>A8Q1P2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl transferase</fullName>
            <ecNumber evidence="4">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730819.1">
        <property type="nucleotide sequence ID" value="XM_001730767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1P2"/>
    <dbReference type="FunCoup" id="A8Q1P2">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1P2"/>
    <dbReference type="GeneID" id="5855126"/>
    <dbReference type="KEGG" id="mgl:MGL_1818"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1818"/>
    <dbReference type="InParanoid" id="A8Q1P2"/>
    <dbReference type="OMA" id="FDRRDLW"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000005">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="291" mass="33078" checksum="0B4A904015E982EC" modified="2008-01-15" version="1">MVHGGRQVAGPATENKTEDGSEGVENRAGSKLPAKHMAYAWLVSAWDRAISFILQQTMYSLSTGPLPRHIAFIMDGNRRWSRAHNMRVQEGHLKGFEALKRVLDLCLSLQRIEVVTVYAFAIDNFKRDPDEVHALMELARTRLLELYEHSDFVARHSICIRVVGHREYLPPSVQETARRVEEATQHNTGPTLNICMPYASQAEICHAAQQATKNSQQLTPASLSSHLMVPDDPPVDILVRTSRVSRLSDFLLWQSNEHTQMHFVDQYWPMFGACDLIPILLEYQRAQTHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1P7</accession>
    <name>A8Q1P7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730821.1">
        <property type="nucleotide sequence ID" value="XM_001730769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1P7"/>
    <dbReference type="STRING" id="425265.A8Q1P7"/>
    <dbReference type="GeneID" id="5855128"/>
    <dbReference type="KEGG" id="mgl:MGL_1820"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1820"/>
    <dbReference type="InParanoid" id="A8Q1P7"/>
    <dbReference type="OMA" id="TRNPFQV"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="109"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="201" mass="20994" checksum="91647018B7A9C6FE" modified="2008-01-15" version="1">MTDLAVAAAASGAMAGLVLTPVELIKCKMQVQMMGTAHTAPPAANALALITETVRKEGVPGLWHGLSGTLVREVGGGIAWFLTFELATQEFLRMRGVSMPGRSATKSDLGSLELAASGALAGISYNVSLFPADCVKSSMQTERELRSQAGLALGTPSGFWKTFHHIYRTRGIPGLYAGVGVTCLRSAPSSGIDCIVCIVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1S1</accession>
    <name>A8Q1S1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730831.1">
        <property type="nucleotide sequence ID" value="XM_001730779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1S1"/>
    <dbReference type="STRING" id="425265.A8Q1S1"/>
    <dbReference type="GeneID" id="5855138"/>
    <dbReference type="KEGG" id="mgl:MGL_1830"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1830"/>
    <dbReference type="InParanoid" id="A8Q1S1"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="143" mass="15918" checksum="B57B2C28025611DE" modified="2008-01-15" version="1">MHRAKVTNLLQIHGCSLSFYWPQMHRAIRVLGWAERVPRSVSQAYFDTRPVGSRIGAWASPQSQVIPSRESLESLIAACQRNFDNPTSDDAHIPVPDHWGGYIVVPDEIEFWIGRTNRLHGPVSVLAQSQHHAACLGCIVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2V3</accession>
    <name>A8Q2V3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730447.1">
        <property type="nucleotide sequence ID" value="XM_001730395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2V3"/>
    <dbReference type="FunCoup" id="A8Q2V3">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2V3"/>
    <dbReference type="GeneID" id="5854754"/>
    <dbReference type="KEGG" id="mgl:MGL_2243"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2243"/>
    <dbReference type="InParanoid" id="A8Q2V3"/>
    <dbReference type="OMA" id="NLAFPPH"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000018">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="295"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="404" mass="44183" checksum="EC16107FB2346ABE" modified="2008-01-15" version="1">MRRKTVVIKLGSSSILSESTLEPKIRIMSSIVEAVSQLRQNGHRVVLVCSGAIGLGRIRMNIKTKPKNLGERQALAALGQLRLMTLWDNLFGMLGINIAQVLLTRSDLADSPRYVNARTTLDTLLMDNFYAVPIVNENDTVSVFEMRFGDNDSLSAITAGIIDADYLFLCTDVDGLYTDNPRTRPDAHRLHVVRNMDEARKATCVKTMGSSFGTGGMQTKLVAAELAMAAGVATVILNGAHPENIVRIVEQDIVAQASSRSDMQLVDPPCTLFLPQRQRLPAQKWQILHAMHPCGALIIDRGAYERISRKESGGRLLPAGVVGVEGNWERLQAVRLKVRQGQNEDDASEAPTSFEVGRALANYTSIECERIKGLQSSQIADVIGAMDTMYITDHIVLSLPSAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2W1</accession>
    <name>A8Q2W1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730455.1">
        <property type="nucleotide sequence ID" value="XM_001730403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2W1"/>
    <dbReference type="STRING" id="425265.A8Q2W1"/>
    <dbReference type="GeneID" id="5854762"/>
    <dbReference type="KEGG" id="mgl:MGL_2251"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2251"/>
    <dbReference type="InParanoid" id="A8Q2W1"/>
    <dbReference type="OMA" id="REAMTAC"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="79"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="324"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="606" mass="68142" checksum="22FAA93E44A1901B" modified="2008-01-15" version="1">MPRILADESQGFLTQRMYSNESRGDTTVPTSLDAQLREWQIAKPLRSALQGTPFHFSQLTDVQNRVLSLLPAIAEGANVLPDGKSRDVLCKARTGTGKTVAFLVPAIQARIHAVQQLEQGHASPSFRAFLEQNGLLSLLEKRDRASVHELKRLFRRRSAGVLVVSPTRELAMQIANEAKKLVSQAKHLYVHTLVGGVSVIPQRKQWERYEPDIVVGTPGRLLDLMNNRSVRDAFSRTQTLVLDEADMLLELGFREDIQTIISGLPPVEERTTFLFSATMDRSIMGIAEASLHEQYRLIDCIPPGEDQVHKRIPQYVTTIQDPSELVPYVMQLLAQDQRIHGNRSKVMIFTSTTKLTDMMYHMIHMLAPTLPGSSDTRVFRLHSLLSQARRSKISQEFRHSDAKPSVLLTSDVSARGVDYPSVTRVIQLGVPPSKEMYVHRVGRTGRRGRDGRADLVVTDFESAFVAFQLNEMPLQPLALTDEPEPELDQDALRTSIAHAQERLRQNKEGVRDVFSGLFGYYISNQQALRVPPAHILHSVQRWIQGVLALPTAPEPNRSIMHMVHASSTKFGSGPRPAERPAGRSLWRSKSAYSRPPKHIRQQYARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2W6</accession>
    <name>A8Q2W6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730460.1">
        <property type="nucleotide sequence ID" value="XM_001730408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2W6"/>
    <dbReference type="STRING" id="425265.A8Q2W6"/>
    <dbReference type="GeneID" id="5854767"/>
    <dbReference type="KEGG" id="mgl:MGL_2256"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2256"/>
    <dbReference type="InParanoid" id="A8Q2W6"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727962" description="Peptide hydrolase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16884" checksum="A1AB1480E5CAB866" modified="2008-01-15" version="1">MLPSRWLIVLIVAACAHVANAYTLSNESLARVLKPSAAQWIQVRSPTSLLSQILIPRVPGTQGHAEVRERLTKPFFDAKDAHGRPKWHVELIPFEAPTPLGPRKFTNIVVTRDPGAARKLVLAAHYDSKYYPEDSPSHGQPHARAHFSAATQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q377</accession>
    <name>A8Q377_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S36, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730533.1">
        <property type="nucleotide sequence ID" value="XM_001730481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q377"/>
    <dbReference type="GeneID" id="5854840"/>
    <dbReference type="KEGG" id="mgl:MGL_2329"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2329"/>
    <dbReference type="InParanoid" id="A8Q377"/>
    <dbReference type="OMA" id="CAPQSVI"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13253" checksum="9A923C2E77B895CF" modified="2008-01-15" version="1">MLRPSLVRAARAHKPMIKFPDRRAPKPEHKPQPHPDAPEDIANNFEQFRQVLESGPHYDPSKLKPFSLDSGKSASGQTGSRDAVTTVFDLPRRFWDTPALRMSPAEMDAIQSGGASMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3A3</accession>
    <name>A8Q3A3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730550.1">
        <property type="nucleotide sequence ID" value="XM_001730498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3A3"/>
    <dbReference type="FunCoup" id="A8Q3A3">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3A3"/>
    <dbReference type="GeneID" id="5854857"/>
    <dbReference type="KEGG" id="mgl:MGL_2346"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2346"/>
    <dbReference type="InParanoid" id="A8Q3A3"/>
    <dbReference type="OMA" id="HEGITCR"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="106"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="650" mass="70820" checksum="D4BE90F1FD379711" modified="2008-01-15" version="1">MDQPPPSVTINSSPSLLYCAPQASASVQDTNGTKNSGVAMRRGIKSEIKPLSLLDSSTSPPRSTQRLSRDITPLHIAHGWKSAEWDQWASNMYNALQTDTSEAVLLGMENFGNSCYANSVLQALYYCKPFRDAVMSVDKSPHPSPLPSLQDGLASEKTLASTPVSMNMKDALAALFHSIALASVRLSADASNGRIHSSSMLEAPAILSQNVDAGALKMFLSTLHQNCNLFDSSMHHDAHEFLNFILNQVGQNLMDKRKRRSQRAREQSFTPLTPSFSSPTVKDHPTYIHKLFQGVLTNETRCLSCETITNRDEEFLDLSINVEANTSVSSSLRQFSESEMLSGRNKFYCDTCSSLQEAEKRMKIKQPPNILALHLKRFKWDDMRQAYVKHACRVVFPLNMRLFNTTHQATQPDQLYDLFGIVVHIGSGAHQGHYVSIIKIGARWAIFDDEDVTFIPESDIPKYFGDAPEVGSAYVLFYQAIDEPDLFDARVNDSSLELAQSTPTGLSNKRASVSQPLSSHHAAPPIVPRNHSHTSFTAPVSGPVPTPVLSQSFVPPPTSVPAITTESASSTAVPNQGPSSTILYDPTAPIGDLLGPSESSPKPIHVPGHSSFAHADHSSRVSSGIWLPTASSDSAAPAALMASKPGARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3F7</accession>
    <name>A8Q3F7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thiamin pyrophosphokinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730589.1">
        <property type="nucleotide sequence ID" value="XM_001730537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3F7"/>
    <dbReference type="STRING" id="425265.A8Q3F7"/>
    <dbReference type="GeneID" id="5854896"/>
    <dbReference type="KEGG" id="mgl:MGL_2385"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2385"/>
    <dbReference type="InParanoid" id="A8Q3F7"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase catalytic" evidence="5">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="195" mass="21073" checksum="D2BDE6D5ED040DEA" modified="2008-01-15" version="1">MLNTPIPPEHAHLFSRVWNSAAIRIVADGGANVLREFVKSWDTFQRPTLICGDLDSISADTHKFFVDLGVCVKRIASQDSTDLQKSIQALEQMEAANSCKAPVDSTFVMRHPLVIYGGLGSRLDQSMHTLHVLAQLAPDASSSAAVPYVQVHTSPLPDSTLQARPETILIASSCVSCLLPPVRLPRLTDVAPGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3I8</accession>
    <name>A8Q3I8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730620.1">
        <property type="nucleotide sequence ID" value="XM_001730568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3I8"/>
    <dbReference type="FunCoup" id="A8Q3I8">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3I8"/>
    <dbReference type="GeneID" id="5854927"/>
    <dbReference type="KEGG" id="mgl:MGL_2416"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2416"/>
    <dbReference type="InParanoid" id="A8Q3I8"/>
    <dbReference type="OMA" id="AKLYHWA"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="189" mass="20121" checksum="739D7415FFBD3347" modified="2008-01-15" version="1">MVRSNLYLQTAVAILTVIKRPSVEPHILLVTQFRPPVGACVVELPAGLVDAGEDGDEGAKRAALRELEEETGYGAASMPGATVSVQSLSDVMYNDPGLTGANMKLCVIHIELSDDAAEPIARPDEGEYIDKHLVPLASLVSQLQGTYNKDGIAYDEAFKKQGYEVDARLSHIAAGIELGSGLVKNSRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3J7</accession>
    <name>A8Q3J7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730629.1">
        <property type="nucleotide sequence ID" value="XM_001730577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3J7"/>
    <dbReference type="FunCoup" id="A8Q3J7">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3J7"/>
    <dbReference type="GeneID" id="5854936"/>
    <dbReference type="KEGG" id="mgl:MGL_2425"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2425"/>
    <dbReference type="InParanoid" id="A8Q3J7"/>
    <dbReference type="OMA" id="SRCHVIN"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="42"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="238"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="522"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="576" mass="64229" checksum="F394305F2381AE25" modified="2008-01-15" version="1">MTAERGAGFQAYARLLDARLLRALADLKYSTPTPVQRESLEHSLGGVARDILARARTGSGKTLAYGLPVIQKILAEKQDIPRSSTAYANTRALVLVPSRELAEQATRQLSAILTYCRDVVQVANIARSVKASVQKLLLSEKPDIVVATPSRALACLQSGDLVIRDSLQSLVIDETDLVLSYGYDADVKAILHEGFLSRTHQTFLMSATLDDDTNALRGLMLKDPVVLRLEHDPTTAANLTQYYVYTSEQDKFLLVYVILKLRLIRGKCLLFVNDIDRCYRLKLFLEQFGLRTCVLNEELPVNSRFHIVEEFNKGKYDYIIATDVNAAELDPTPAKSSSSASSKSQRSKEFSVSRGIDFVAVACVINFDLPTSTRAYTHRIGRTARAGNTGTALSFIVPRSEFGQKKAIGCSTCKYDEQVWDRILADQKAHGLQIHPWNYDHTQVDAFRYRMEDALRSVTKVAIKEARIQEIKQEILNSEALKAHFEQNPRDLEYLRHDRALHPARVQAHMKHVPSYLRPRIAAIPGTAQPPTPSYVPKNKPRISKQKGKGSTGGSKSVSRSKSGSKKKNDPLKSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q434</accession>
    <name>A8Q434_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">YIF1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2493</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730111.1">
        <property type="nucleotide sequence ID" value="XM_001730059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q434"/>
    <dbReference type="FunCoup" id="A8Q434">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q434"/>
    <dbReference type="GeneID" id="5854418"/>
    <dbReference type="KEGG" id="mgl:MGL_2493"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2493"/>
    <dbReference type="InParanoid" id="A8Q434"/>
    <dbReference type="OMA" id="RHVAQVG"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52351" checksum="FFF3F5091576EE1E" modified="2008-01-15" version="1">MYPQRTGPSGRVPPPLQRPVPTHPRASAPSRAGSSDASATSYQGAPAQPRPPRGGPWAGGRPPTQGRPVPNAPRRATTPRTSMTGAQRVVRPGPLASQPMEYQRIQSPAPMSPTTQDFSSPYTPPPYRANSITGQPQSTDTYPSPANGWGADGVSTPPVVQQDAYGMPVTPQDSAWDSFSHAAGIPAFGSSNMMNDATTQMGMQLGRHVAQVGGEYMQRNFRALLPMPVLKHYFNVSNSYVLHKLRIILFPWRHRPWSRRLRYSTPYGASGIMSPTQSSSTIYAGMSTPERSLSAEGGHPSGSVEPVSYCVPREDVNSPDMYIPLMAFVTYVIATSFIYGIRGRFHPEVLGYTASRAMAIVLIEFSAIKLGCYLLNIQGDHTVFDLIAYSGYKFVGTLVILAVGSLHISRWLYWLTFLYMFAANAFFLLRSLRYVVLPDPTSPSSVTVTQGQRAARIQFLFGIAMSQIVFGWLLIVGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q485</accession>
    <name>A8Q485_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730128.1">
        <property type="nucleotide sequence ID" value="XM_001730076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q485"/>
    <dbReference type="STRING" id="425265.A8Q485"/>
    <dbReference type="GeneID" id="5854435"/>
    <dbReference type="KEGG" id="mgl:MGL_2510"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2510"/>
    <dbReference type="InParanoid" id="A8Q485"/>
    <dbReference type="OMA" id="SEDEYWP"/>
    <dbReference type="OrthoDB" id="3350997at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="505" mass="55919" checksum="84380D7AA5DFFC59" modified="2008-01-15" version="1">MSEVSAQPSHKRALGTRAKLRRTFSSRSQRDAELDTSRRRSFMGKDHHIGIRGNRIRNSVHNDGHSDGDEEPMDPLELADLNSIINTRKSMASAQALAKQEPENGKDVDLPCHRRSSTPSVRLVKFAPLPQVLEDASKSIIEKDDASDLDDAAASTSATTTFLAPPPWRPLSRSNGSEESLIPNDTGSLLQRTNSAGRCERLDDAESEARGRSLTRAWSPFRRQRNESLSSLSPSPSRPLAGERSRSRSRELVRAIRPGGTGMVTLLDGKRIRARQVGDPQEEQDADADLNARLWGFAALERRRLADDTKSAAASTTSDMSTPIARGKLTHSQAEEAQRRHKQEMDALGDEALTHVRENKAHANARPRKISSTVHQYRVDPSVSMPSPSPRLPRRPDARGIIVVPLPQLGMRPRYPYEGRSWLYSVPYDDDDDDDDEDNSDTQNKDTIAGQDDDGPDEAPPSSTRYRATTVAARKEVYMSHKPGKESEDEYWPKPSATRAIGSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4P1</accession>
    <name>A8Q4P1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2592</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730210.1">
        <property type="nucleotide sequence ID" value="XM_001730158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4P1"/>
    <dbReference type="FunCoup" id="A8Q4P1">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4P1"/>
    <dbReference type="GeneID" id="5854515"/>
    <dbReference type="KEGG" id="mgl:MGL_2592"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2592"/>
    <dbReference type="InParanoid" id="A8Q4P1"/>
    <dbReference type="OMA" id="FRKTCAD"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="165"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="789" mass="85410" checksum="89BF8206F0418CA0" modified="2008-01-15" version="1">MQPFRAPSTSALRSRRDASGRGGAAVATAGLAEKRMPSGGGAVAPNMGRRIVSQGLARTQQRSGELGTSTVPAALQVDNTSFEEWMKMATDNKINATNTWSFALIDYFHDMSLLRSDSGDGSINFQKASCTLDGCVKVWTSRVDSVMAETGRLLSGLQDEDATAHGIGDSSAAEVGDRSYSGADDASSAVDRAGVDAEDQRRGKRRHRAQEATLAKSFAQLQVKRFDLEFSVDPLFKKTSADFDEDGAGGLLMNHLHVDDHMKVVFDASDVAATTEADDHDMDQNNSTDAVSANQQTLTPPSSDTPSMDMEKLRARIYAAAAQTNPSVPIQMEPLASLLDTRTICPSTANFTFAEGNEAAPPTMQLPELDGIDGASMDVEDMPEDLDGADGVDGLDFFDGQVGDDVAPTNEELAFDVAVAHNGRRDTDEHERLFDYFDQKMQKNWAGPEHWKMTRIHMKKPGLVAGATTTDEASSVVATDSGVKAKYRRSKEEQAIDFLSAEPPPPAKELFAPSATPSAIKLTKSAQSASDAHLLPEDHHFNSKRLLRLFLKPKATILLQRRTAASSPAGPLDPWNDEDGMWSENHVESMPAEDGGFDTGLFEDHDPYDDVLVPPAEPAPADAFDADSDIDEEAWANEAALRRVRPEFVDHAKRAKQVDVKRLKDNLWKSLDLDEHEPRTLDTALDELESMYTPAKYNEISTSFCFICLLHLANEEGLEIVAPSSAKTIPGTDGDTTVSSPGAVLAAAARAGRVVTDDDEDGDNMEEDSAHVCDLGSLQVRRDPHVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4T1</accession>
    <name>A8Q4T1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730248.1">
        <property type="nucleotide sequence ID" value="XM_001730196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4T1"/>
    <dbReference type="FunCoup" id="A8Q4T1">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4T1"/>
    <dbReference type="GeneID" id="5854553"/>
    <dbReference type="KEGG" id="mgl:MGL_2630"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2630"/>
    <dbReference type="InParanoid" id="A8Q4T1"/>
    <dbReference type="OMA" id="IAHMFIR"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="633" mass="72786" checksum="B3F75AFD5E6826E9" modified="2008-01-15" version="1">MGLLSLGTPLAWEDARELSEHVRKHGIEQFLSVWRESRDRQNDPLLWGDELEYMVVVLDHAHKTARLSLRQGEILERLNTCCMKELQNLAPEDRPKFHPEYGRYMIESTPGSPFGISASELLRVEPNMLLRRDITRQHLRDNEVLMALASYPRLGVLDTPFTEPVCELPPRGVASHSLFLPDEIINQHVRFPTLTANIRKRRGSKVRINVPIFRDAHTPTPFIDPSIPWERAEFAEDPEAKLGAAYADHIYMDAMGFGMGCSCLQVTFQARCLADARRMYDQLVPITPLLLAATAASPVYRGYLADVDCRWNIISAAVDDRTPAERAEHPLKPAEPMHNSDTGPRTLRKSRYDSVDSYLDAREWNDVDLEMNMPVKQRLMECGVDELLAEHMAHLFVRDPLVVFSENIDLDDERSMDHFENIQSTNWQTMRFKPPPHGAHVGWRVEFRPMEIQLTDFENAAYSIFLVLLTQVIMTMPVDFCMPISLVDVNMQRAQQRNAVHTQRFHFRTSAQTKETREYTLAELFLGTPTMPGLVPLTRTYLDSLDLDSDTRRRLDEYLDFVAMRADGRLVTMATFVRDFVTQHHAYQRDSVIHDEINYDLLCVLDAIERGTQEAPTLLPSWYADRRRHAGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5L5</accession>
    <name>A8Q5L5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2792</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729806.1">
        <property type="nucleotide sequence ID" value="XM_001729754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5L5"/>
    <dbReference type="FunCoup" id="A8Q5L5">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5L5"/>
    <dbReference type="GeneID" id="5854107"/>
    <dbReference type="KEGG" id="mgl:MGL_2792"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2792"/>
    <dbReference type="InParanoid" id="A8Q5L5"/>
    <dbReference type="OMA" id="EIKAFWV"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11369">
        <property type="entry name" value="RNase_PH_RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033196">
        <property type="entry name" value="Rrp43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="51"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="313" mass="34301" checksum="A3FB70EA21A0A06E" modified="2008-01-15" version="1">MSVSAGTSSSDMEKIDVASAPVTIFKKLHPVEYLERHLKERIREDGRTLDQLRSVSVATGTLSQPFGSALVRLGEGTLVTASVTARIAHPTLERPNEGFLIPSVDLSSLCSPLYNAGPPEEEGQVLTHNLQMFLNNSGILPRSALCIEKGLAVWAIYVDVVCVSAEGSVLDAAALATVAALHDCQLPRIDRFVNSSQAIFDPDTKERLPLMNLPIFMTLGMYESTYVLADLTAFEESLCTGSIQVGLVDVNNEVNDPDIAKYDVFWLKVLGPCTTKHPQPLENEALIEWCIEKAQKRAQKLRKLIKDALQKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q622</accession>
    <name>A8Q622_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729857.1">
        <property type="nucleotide sequence ID" value="XM_001729805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q622"/>
    <dbReference type="STRING" id="425265.A8Q622"/>
    <dbReference type="GeneID" id="5854164"/>
    <dbReference type="KEGG" id="mgl:MGL_2843"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2843"/>
    <dbReference type="InParanoid" id="A8Q622"/>
    <dbReference type="OMA" id="EKGKCER"/>
    <dbReference type="OrthoDB" id="3362535at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="500" mass="54920" checksum="EF639227B545E03A" modified="2008-01-15" version="1">MSEIAQLSGAIDRQRSLIAGQPEHRDVHGSRPARAAQVRGRGRARGRGLGYGSIPRHRSLVLSRDPKDEWVHRRSKKSMTLVNSAVYEPPKEHRFRAEAPSMHRGHRSEVVVDGVPFVFDESGTKLVKKSTLGANASSSVMVTPTAASAATGESADTSASVAQAPPPTPTIPRQTSINGQAFVRTKNGNLINKALVLERREARARQERMQRLAKLGRKLGHAHKQQRALERAKTPQLCTYYTRTGTCRRGTQCPFIHDDQRKALCPGVLKPSGCVLPPGTCLLSHTRCPQNVPHCVHFLRLHSCRNGDACAFTHAQVAHDAPVCRAFALLGWCDQGDKCLHRHAKECPDFTAKGTCTDPACRLAHVSIPPRLEPSASSIDTPLFVRDDAGAEEERYFDGDHNEEDNTEHLNALYVGDELGDTDAASAQQPFSQQRDFIGLDDMDFSDVSETSSDNVIAEEHGSGREQDEDDDGGDDDEDDEEDGETERDDAEVDEFLGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q651</accession>
    <name>A8Q651_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729867.1">
        <property type="nucleotide sequence ID" value="XM_001729815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q651"/>
    <dbReference type="FunCoup" id="A8Q651">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q651"/>
    <dbReference type="GeneID" id="5854174"/>
    <dbReference type="KEGG" id="mgl:MGL_2853"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2853"/>
    <dbReference type="InParanoid" id="A8Q651"/>
    <dbReference type="OMA" id="NAHNTIT"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10232">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSsz1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000021">
        <property type="entry name" value="Heat shock protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="534"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="622" mass="66129" checksum="AABE979305BC3A4D" modified="2008-01-15" version="1">MATCLRLCALPPFFFVDAGGSPGHSADDDMSQEEGAVIGINLGNTYGSLACINQHGRADVIANESGERQIATRIAFHGDQVYHGNGATPQLIRNAHNVIDNFVHLVGRPYSDLSEEEKARKSAAVLDVNGVPSFEVEINGNKTILSAQDVLVRFIGVLYNAAKDFMSGVPIVGAVLSTPLWYSDSQTAAVADAAKQAGLHLLQLVPAPAAALTAYGLTMPKPTGELPSHPDGEKGEPYAPDKILDRNVLVVDFGGTAIDVTVYAARAGIFSQLAYEHDKSIGGRALDDVLVHHFAKEFHKKTKTAIGEHDARAWAKLRNEAEGTKRALSASHSAQCSVESLAEGLDFSGSVNRTRLNVLASGIYQTAVADVQKAIAAAGLESCQIDEIILAGGASRLAGLAEQLSFLFPEDSNTHITYSIDSDQVIARGCAVYAQSLVHLPKDSEERKFVASMPATRAERRAALTMPATTRPLGVVVDAPPQESVAKQIVNGKLFVTLVHAETPLPARRVVRFPVTPNSSSTLIRLAQGTPKVRVDKVDPEPLDDDEDAAADEDDEPLEPEEVRSAYIEPDAASLAELVVPHAALCQSITLQVIVHSDGQVTVEARCDKKSEVAASAQIGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6D0</accession>
    <name>A8Q6D0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729940.1">
        <property type="nucleotide sequence ID" value="XM_001729888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6D0"/>
    <dbReference type="FunCoup" id="A8Q6D0">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6D0"/>
    <dbReference type="GeneID" id="5854247"/>
    <dbReference type="KEGG" id="mgl:MGL_2926"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2926"/>
    <dbReference type="InParanoid" id="A8Q6D0"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="172" mass="18854" checksum="9E2E3CE099C0FCCC" modified="2008-01-15" version="1">MASEEVKQKKSVTVDEALKKKEKKEKKEKKERKEKKEKKEEQHDAVGEDSVGDVSMADVSTTETDVEVDPSTLSAIACNLVILAGDISPVDILSHIPVLCEDTGNPYVFVASKDQLGNASSTKRPTSCVMIVPGGGKKAVEKGETKVKEDYQEDYSFLHKEASRLVQQVLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6N5</accession>
    <name>A8Q6N5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730031.1">
        <property type="nucleotide sequence ID" value="XM_001729979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6N5"/>
    <dbReference type="STRING" id="425265.A8Q6N5"/>
    <dbReference type="GeneID" id="5854338"/>
    <dbReference type="KEGG" id="mgl:MGL_3017"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3017"/>
    <dbReference type="InParanoid" id="A8Q6N5"/>
    <dbReference type="OMA" id="PCIQGQV"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="483"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="514" mass="56600" checksum="A47A4B21B3ABFA33" modified="2008-01-15" version="1">MKTTPADTIPALVGRLRATFLTGKTRCVEYRKNQLKQLYFLVKDNEEAFVDAIGQDLGRPGMETTFAEVIGIENDLATSISQLSKWSKDECVGAGPPFMLHGTKIRKDPKGTVLVLGAWNYPITVQLGPMVGAIAAGNTVILKPSELSPHTAQLIADLWSKYMDTETTAVVNGGIPEATALLDQRFEHIFYTGNGRVGRIVAEKAARWLCPVSLELGGKSPVIVDASADLKIAAHRTLWAKAFNAGQTCVAPDYCLVDRRVQDKFAHELLQAQREFWPSRDHQERDFGRIVSDNHWKRIHSLVSSSKAELVVGGTAGADQAKRFIPLTILKNVDASDSVMTDEIFGPVLPIVPFDTIRDAVDFVNERDQPLALYVFTSCNETRDYILAYTRSGGVVRGDCLLHYAIDSLPFGGTGPSGYGSYHGKAGFDCFTHERAVVDAPSYGMLGKLVEVVMARRYPPYSKSKLDFFRFVLPKLVWFGRPPQPTRSSKSIDHPPSKVRTTAPRHGGHPLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6U5</accession>
    <name>A8Q6U5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730070.1">
        <property type="nucleotide sequence ID" value="XM_001730018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6U5"/>
    <dbReference type="STRING" id="425265.A8Q6U5"/>
    <dbReference type="GeneID" id="5854377"/>
    <dbReference type="KEGG" id="mgl:MGL_3056"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3056"/>
    <dbReference type="InParanoid" id="A8Q6U5"/>
    <dbReference type="OMA" id="WPLHDLD"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="47"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="270" mass="29489" checksum="E503418501686871" modified="2008-01-15" version="1">MLIRSARPLCRAGSRWWPSTHRPICSSSRVLAAKDPVALGEAIRHVMRLSAQPVALVSAFVPSEDPDDPSPQIHSTTLSSFTTVSLAPPIVAFSIRLPSRMADALLSGAKTPPPSNNYDATSVVSTFARKPHFLIHILSSKQTSMSNFFARPGAKPYSLRQSTKIETHPFNQHPMQPSQAVDGQLIPTESIGTLACSLVYQLDLTSPDLHGTTEFVNGCVHTNEVGSALFLAQIHDVEVGHAHINDVKQKPRPLVYWHHGYCTTQEDSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7V7</accession>
    <name>A8Q7V7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729593.1">
        <property type="nucleotide sequence ID" value="XM_001729541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7V7"/>
    <dbReference type="GeneID" id="5853899"/>
    <dbReference type="KEGG" id="mgl:MGL_3137"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3137"/>
    <dbReference type="InParanoid" id="A8Q7V7"/>
    <dbReference type="OMA" id="FLREWHP"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF30">
        <property type="entry name" value="SERUM PARAOXONASE_ARYLESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="520" mass="57682" checksum="959D95A1D516D6C4" modified="2008-01-15" version="1">MIVVGWFALQWELVFIKAPMVFRSARHLLPEWYVRGGGSSSAPVKGSITCKSLRSGYIDDPQAYRVNPMSGSHAQVAEACEDLHMSTKLGIVLMSCDPGRVVWNTFMNSLQQPATHGALWMSEYKSNDPQPVLLHIHGYPEAEDFHPLGMGLYEVSEHQARLFLVNQRTHASTIELIDLERRADSDESTANRNHRASWHARYVRTLYHPIATHTPNAIHAVNLNELYVTNSHVVALRSPPRPAYEAVLASQFGDAIAPLVYKVVTYKPLTAMWQKLDSFIGWGYVAHVHMAGLSQDTDHDGDDNVNYKTDASMQAVAASMPDLLHSMRGVSAFIWAGRVPFANGIVATEKNVIVAATSAPGLYVYDQTNDTHARRQQQRPRAFVPTPFFPDNLAVSRGPQPDTLRIVVAGHPSLKDLEHVVSHPHTQRYAPSWVVEVFYDESLSYTGDDADVPYPAQKALMTVPNGWHVRTLLQTNGRSTALVLSSSSSAVWDPTYAAHGSFYVSGLYEPAPIVCRGMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7X4</accession>
    <name>A8Q7X4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729606.1">
        <property type="nucleotide sequence ID" value="XM_001729554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7X4"/>
    <dbReference type="FunCoup" id="A8Q7X4">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7X4"/>
    <dbReference type="GeneID" id="5853912"/>
    <dbReference type="KEGG" id="mgl:MGL_3150"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3150"/>
    <dbReference type="InParanoid" id="A8Q7X4"/>
    <dbReference type="OMA" id="MLWFIGQ"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="468" mass="52539" checksum="AC7A2678FF330156" modified="2008-01-15" version="1">MSRWRWTYVVLGLTLRIALLFWGTYQDKHASLPYTDVDYAVYNDGARALWTSCPLSATIDSKLYEDEEDLLNVPELAENVHCARGLIPAVSRFVLKNDPARSDTATMEWDPVWTPYLIFSYAWTRPLFRFLGSLGDPFVRTTYRYTPLLAMLLGPGHVQDGADGDGMWPWLGKLIFALADVGCGILMWAILDERQAMHAYEAPALRHAKLLTHLPGTLWLVNPFPAQIATRGSSDSLVGLLVLAFLYLLIRATPEMSLVRTPVLESDKLPPRHDPSDLRVASTSCFYGAAFCLALAVHVKIYPVIYGASVLAHLANYQHYALVMLCGIPKPKRWDVLRLGLRFGVCAAAFCAVLTAFAWGIWGEPYIRHALLYHVVRQDHRHNFSVYFLPTYLSLDHSALSHLAPLAPWLRQAAELLSFVPQLLTVGFAGFALGGKDLVMACTVQTIVFVAWNKVYTSQVCWHRLFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7Z4</accession>
    <name>A8Q7Z4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3165</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729621.1">
        <property type="nucleotide sequence ID" value="XM_001729569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7Z4"/>
    <dbReference type="FunCoup" id="A8Q7Z4">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7Z4"/>
    <dbReference type="GeneID" id="5853927"/>
    <dbReference type="KEGG" id="mgl:MGL_3165"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3165"/>
    <dbReference type="InParanoid" id="A8Q7Z4"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="40"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="360"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="426" mass="46397" checksum="AF865BD0EAC9421F" modified="2008-01-15" version="1">MIRALNLFRSRATMAQSMLRSGANVGMQKRFLSIHEYLSMGLLNKYGINTPKFFPAKDSDEAYLSTKKFDGKPVVVKAQVLAGGRGKGHFDNGLQGGVHLVKSAEEARDLTGKMVGSKLITKQTGAAGRVCNSVMIAEARTPKHEYYVAILNDRVRQLPVLIASNQGGMSIEEVAKENPDAIITTPIDYTKGLDMETAKQVAHKLGFSGEQQENEAADTFVKLYKLFRERDATQVEINPLAESEDGAVLCMDAKLGFDEHADFRQKEVFEMRDLTQEDPSEVRASRYGLNFIKLDGNIGCLVNGAGLAMATLDLLSLNGGKPANFLDVGGGANAEAVKKAFEIVLEGEGVRAILVNIFGGIMRCDVIAEGIIKATKEMELKIPLVVRLQGTKEQEAKELIRQSGLKIQAYNDLDEAARKAVEAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8F4</accession>
    <name>A8Q8F4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alkaline ceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729717.1">
        <property type="nucleotide sequence ID" value="XM_001729665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8F4"/>
    <dbReference type="STRING" id="425265.A8Q8F4"/>
    <dbReference type="GeneID" id="5854023"/>
    <dbReference type="KEGG" id="mgl:MGL_3261"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3261"/>
    <dbReference type="InParanoid" id="A8Q8F4"/>
    <dbReference type="OMA" id="IMFEPLR"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29329" checksum="AF78046A6343D543" modified="2008-01-15" version="1">MYRVHTERLASRFYLCSLGVGVVGFGSFLFHMTLKHEAQLLDELPMIWVGTLLTWSMLDQTLFFGWRVNRLILPTVLLSLVVWITVTYVTNGDPVFHQVAYASIMTVSITHAIFIMVHPNAPLNVSDSSRRMRADARRLERQGTISFIVGFAIWNVDNIFCGRLRAARDVVGYPWAMLLEGHGWWHIFTGIGAYLLVLACEVITMSYMEHPDNFVMVYSMLPYLKRVKPYNPSHTLLRDFSAKKQPLQDAGTKKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8L7</accession>
    <name>A8Q8L7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729749.1">
        <property type="nucleotide sequence ID" value="XM_001729697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8L7"/>
    <dbReference type="STRING" id="425265.A8Q8L7"/>
    <dbReference type="GeneID" id="5854055"/>
    <dbReference type="KEGG" id="mgl:MGL_3293"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3293"/>
    <dbReference type="InParanoid" id="A8Q8L7"/>
    <dbReference type="OMA" id="DICCAYL"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="763" mass="85457" checksum="C9BA7F93352EF48B" modified="2008-01-15" version="1">MALHLIQDVEAAGAELFTLLVSTTVRDSWPEIESDAPHLPSVLHAIHILLTRFNAVSSPSPRAKATLQSLNALKNGLTTPLNDDLFGEQQPAASVPSLWASRAFFSYAVSLQLVWRQVESSGGRRPVLPPPVFPEPETILLVHGLCAPNLNWYQKCLEALGILKTRLHYSNEPPNDICCAYLMEIFVAITHAAIVQLKRHPTERHAQVWRHVIGGLLPPLALFLGGSVPASNNDVLNVQDTVSSFIAFYEPVNDWMHLDAQIMAPSHAATLPDLMQDSFAAWLPGHSKKTTSIELENLHQYASTSVQSFRQIVHTSLLHNPSACGNLIERAVKEPCLQLVLAMELNHLLSEWTEFMSAEFMHMHAICYLLQSGAPQNLDMLCLYMGQQLLPHTLVHVLSHMDQSMWSHPDDALNLVILFVEYLSYYSKESGNPSKGAAYVFMRRRLSCFNSHALPEEYLTLLSRWCRCLVGSDDMSELLTASPPWLLFRLTPSIFKLLIEAFLYGFFDESTLLNAFAYFLRVPLRYNVPCAVNWLVRYTTMTLAKAQYDPKLWSLIFLLVRTLHMLFMSDACPPLIRSMLAGVVLPLLQNERLVLMTHTSNVNIPVFISTLQSYTDPHLPQSPWIVDVLMMCEDAKPWYSLVQRIGIITLQGLDTCIARQLLGVALQTRAEQVWTIKLLAAVFSLLHLNSKATKPLSLVRVILLQWDASSSKPEHIRNLGRILVLSVLLSKNLPASADALETVFGSLLTPSAEPLAHILRSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9C3</accession>
    <name>A8Q9C3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_3455</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">COPI-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the COPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729420.1">
        <property type="nucleotide sequence ID" value="XM_001729368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9C3"/>
    <dbReference type="FunCoup" id="A8Q9C3">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9C3"/>
    <dbReference type="GeneID" id="5853727"/>
    <dbReference type="KEGG" id="mgl:MGL_3455"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3455"/>
    <dbReference type="InParanoid" id="A8Q9C3"/>
    <dbReference type="OMA" id="DFIEDCE"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="13">
        <location>
            <begin position="16"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="14">
        <location>
            <begin position="686"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="15">
        <location>
            <begin position="838"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="614"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP42206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="952" mass="103792" checksum="711D2FE368DAEF5C" modified="2008-01-15" version="1">MSFKKEDEMSYRHDKTAVIQEARVFNQSSISPRRCRILLTKILYLLYTGEKFSQQEATDLFFGATKLFQNKDAGLRQMVYLAIKELAPCAQDVIMVTASIMKDMQPNTEVVYRPNAIRALMRVIDPSMVQGIERYLKSAIVDRNPSVSCAALVSSYHLFVESRDVVKRWGNEVQEAINMRPAVTQNTSSFSGFGGLHSGITLRFGGGGSDSASHAVEQTNVPSMSYLMQYHALGLLYLMRQNDRIAVTKMVQQLGQPRQGVVLRNPYALCMLVRYTARIAEEDPNMRASLIQLLEGWLRHKSDMVNYEAARALCTMPGVPAEPQTKAISVLQMFLSSPRSVLKFAAVRTLAELAQLRPAAVQSCNVDMESLITDSNRGVATYAIATLLKTGNESSVDRLIKQISGFMSDISDEFKVIVVDAIRSLSFKFPSKQAAMLGFLAGILRDEGGYEFKRCVVEAIFAMARYVRGCKEAALSHLCEFIEDCEFTKLNVRILHLLGAEGPRMPEPHKYIRFIYNRVILENAIVRAAAVNSLAKFGAYNEHLTARIRVLLRRCLEDVDDEVRDRATYALHTLEPPSMPVITLDDTPNLQVLEQSLQSYVDSMATSAPFDYESVPRALDGPETESGPASDPLLPTGGAPGTAGAMMGVEGGTGGVMAGIGGEGAGLSAANTMGAEASGLDAYADHATELASIAEFASYGKLLTTSPVNAPVQLTESETEYIVTAYKHVFAEHIVLQYNVTNTLAEIVLEDVVVVVGGLMEAGLEEEFILPIPCLSSATPSGKVYVSIRRDPSLPFPLATLTNTLRFVSKEVDPSSGEPEPEGYQDEYQTEELDVGVADFLQPVELDFAMTWDTLPASASETFALTALESLDASCSTLVELLGMQALGGTDVPANPSVHTMMLAGLLACPGGLETVLARVRMMHQPSEGVTMELSVRAPSDEACLFILSAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9N9</accession>
    <name>A8Q9N9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3522</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729487.1">
        <property type="nucleotide sequence ID" value="XM_001729435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9N9"/>
    <dbReference type="FunCoup" id="A8Q9N9">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9N9"/>
    <dbReference type="GeneID" id="5853794"/>
    <dbReference type="KEGG" id="mgl:MGL_3522"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3522"/>
    <dbReference type="InParanoid" id="A8Q9N9"/>
    <dbReference type="OMA" id="NCCKFER"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="84532" checksum="B32AD44BFA47EA32" modified="2008-01-15" version="1">MSGRRAEIEAKRAKLAELRRAREEREERARKLKAGPGDPHAHASAVSAASIDELVASLLGSAHDASKPSNPSQHAAPPATAASPSKDVAKADTVVTPSSSAQPASTSTTITDPSTSQGSTHAVPSDAPSVRPLTPPSTQPGSDSQSSHHEEPHDEPSTSSKHSTMIPTAQAPQRILYTKQVQTDPIETDDVAPIHAEKDAAKDAGIVHQSALASPTSPSAPAPQPPSHSPHERVPCQGAADGSVDLVEPSISLSPLERDTHQLPDADFTDFVHAKATVMERMLDERYNVLTDYTHVPTEDAQESKQTSMHLVRTFMDDALLETRSVTDVDWSAKHPELVVASYNRKRVLVHEDDHDGIVAVWNMHMRERPEFVFTAPTDVVSVLASPFHPNLFIGGTFGGQVLLWDTRQRGLPVQRTPWAFSASATGLTHSAPVYTVRLVGSAQAHQLISASSDGVVCTWSLDMLARPQESISLTNPMHPRSAKVGVTSLDVAPHDTSHFFVATDEGNLFDAQRFDRAGIKAGLSMSHAYVGHTAHVTRLECHPTHMFEERLPLSISELFLTSSMDWTTALWRPSNSTTSPAGTATDVASAAASASVSSIVSPAKNFSVSSASPVPSPLRVSSSSHTSLPSSMYYYPHANPRIATSQRTNPLAFRTAASDTPPWSAVAPLARFDQQQDYVMDVRWHPQHPGIFAQVDASGHVDMYNLCQSVDRPVLSASTPQGRGLNRVAWERRGTLPEHGTQGATRLAAGGMDGRLHVFQVPDAFITVRGEADVTEMERVLAAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9R8</accession>
    <name>A8Q9R8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729511.1">
        <property type="nucleotide sequence ID" value="XM_001729459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9R8"/>
    <dbReference type="STRING" id="425265.A8Q9R8"/>
    <dbReference type="GeneID" id="5853818"/>
    <dbReference type="KEGG" id="mgl:MGL_3546"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3546"/>
    <dbReference type="InParanoid" id="A8Q9R8"/>
    <dbReference type="OMA" id="VAFYYLH"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="378"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="620"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="927" mass="101467" checksum="E82241157333568E" modified="2008-01-15" version="1">MHPRRSFLQEEEAHVTEDLYGEPEDKRRPVEKPDPDALEQAESASKQPLAATPTTTDKDEKTSVPSFEKMSKEMVSMDVTQDTSAREGPGKSPIPRSLESETLQPVERPDDVSRISESESFRPPTMLEPIVDAEPMDMSVVSDTRRKSDTSHAMDVTPCDETEEMQRAIQALVKQLMIKYPWSEKESHALLEQNHRIVASLRVPAALGLQKCAEQEPGVAAGEIDAYLKQRIHECQQSQEAKLTRLRNEYRAKHQAWVKYCERLDQEHEQRAMHQDDPALSASALPSTSTTSSSATTRSFRRGGIGSGSFGDAVRSEAEFQEILASLENAEMQDPVVRAARTSAVIPDMELKGTPFFDGDNGHVADPVSFYFGGFDPDVWSEEERATFARRYVLYPKQFGRIAEKLPHKTPNQCVAFYYLHKHLEGYKALLSARHRERRKKTKSRPKKSKGSALMADIAATQLDAEDEEKRSATGSTNPVSTAVPAPAPTSKRRSDEAAPKSKKPRPASKPRRDAPLETDKSSVGVGAETELERDLAAAEALEALASLAAPVAAPAPAPMPESAAVMPSSSTPAPAQASTPVSDPSAAPATTASPPTASTLAPEPKKRRPSRVKDSDEPKSRSRGPHWSMSERAEFLRLLAIYGKDWNALAASFPAKTPAQTRNFFARHASESSHFQEAAGLAQKHAHMSWEDKAHAAAAFVRHWYDSLPEGSAKASILGWPSPGMKPPSPPPREMSAAIDDETDDEDQFSAGTEGPGHAHPVPPPGMLYSNATVSPPPNMLATSTRSHPQQHAHAHIQVPLPHAQTPQTAFSGASQPQQVPPPLGAETHWSPVAQPMMGFSYPNYSAPPRPTHTPSPASSMYYREPNAAPYGAAPMPPPMSMYNYPMPPKYAPHDSMYAPSPASRLPMRSAPNMGYFHPRPDRWHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9Z1</accession>
    <name>A8Q9Z1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729103.1">
        <property type="nucleotide sequence ID" value="XM_001729051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9Z1"/>
    <dbReference type="GeneID" id="5853410"/>
    <dbReference type="KEGG" id="mgl:MGL_3570"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3570"/>
    <dbReference type="InParanoid" id="A8Q9Z1"/>
    <dbReference type="OMA" id="AFGWEGI"/>
    <dbReference type="OrthoDB" id="3336072at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="799" mass="91332" checksum="C45D3A2A6ED8A681" modified="2008-01-15" version="1">MHVSSAGCDNGNIRIKYQMEQDHLQRFFTIGLALRLEPLPKLSYDLVKRNQENNDARDAFDIGQGQRLKPRISTFSPTTFDHVKEFLSDSRLCECVRTWSEIFSILDAADDDPHFSKLRHFFDARLSTLMDLYRQDDGFEEEPDDITPTRLERKSSVKSSSRAPKRLQWPRRASASTADQSLHPARSIFGSVRKPSSSHKPNEFEKSFSDKFDLWLDDHEPRRVRFGVRLDLDRVCLANSRNQASDMNSKKPFHVSDARLKFTEGLDPEHEEPSIRSDDNAGSITSRRSFVQRMFEKGLRRESQNSSNPPTWLQNHEDMTNASNQAFDDSDEEQEASPFGSPGCSTTRHGSVPSNASRPQLNGASKAAELERVEEKSAVDLNEKLIRGVHYLGLNDAQPVSYFKEGQDFISLLRKASVQMQTLPWSYGQQDPLSTIITYAFADAFGWEGILHLCYGKHSACEREQIFSALGRAADMELHRKEKYDAVLSWRDKVWSNSDKETLCEDETPQTLPSFNSESDQIKSSQEPQKDEIILDPLSKDSDASCYKSSHDKWRTWEDWRLLFTSLSAWVSEYETTRVQSCLSHEYNLENVFQTRPCETCPNVLPLSVEKDAISSQFGFWRLSGIPSALRLESNQEHMDYRWARVRLESSMIGTPLVMTTAGVQFFLMQLTSAPWVYHGAWELDYLDKCIFESSITRERFPPPGDSVVTPLSPSYSKRENRVECPYPSVRGAWSPDEWKKWLGGLREGHIITPTISWQGWWTLIAVLNGADHSGRPFDLQLRAPGDPVQPDEDGSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAA9</accession>
    <name>A8QAA9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729201.1">
        <property type="nucleotide sequence ID" value="XM_001729149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAA9"/>
    <dbReference type="FunCoup" id="A8QAA9">
        <property type="interactions" value="461"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAA9"/>
    <dbReference type="GeneID" id="5853507"/>
    <dbReference type="KEGG" id="mgl:MGL_3668"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3668"/>
    <dbReference type="InParanoid" id="A8QAA9"/>
    <dbReference type="OMA" id="DFRWLHA"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="427"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="819" mass="92215" checksum="9AD3011AEFE87BBC" modified="2008-01-15" version="1">MGMKVLVTGASGLLGRAVMQTCIRAGHHVVGLAFSRASDAIQQLDLTDADAVYDVVRREHPEVVINLAAERRPDVVEQNPDAVKKLNVEAPAVLAKACRELDPPAYLIHISTDYVFDGRNPPYAVTDATNPLNAYGRSKRDGESAVLASALPGHATNLRLPVLYGETLFPGESAVNVLLEAIQPRESRIRMDAHSVRYPTNVTDVARVIEQLATLYQKRLHSSSSPMPSALHFSAQESMTKYDMCLTFSRLWNDVCGEAVSSTDHLNPQYEEDPRAATQRPGNCHLDVQATADLGIDVHCVLFEEWWRDYLARCGPPTSSSKSTESQSQLESKPDINNSPPSASVSDNERTKPTREDMDHNQGTKNVSNSEDSSLGAMGDKALPAPAVADHNSHNEDDDLERYGTRTPSEQLQTSDHTNETQCDPPVEFTVRVGDPQRVGDPVTAHVVYTVRLTTNAPWFARSELSVLRRYSDFRWLHAAMVHNHPGVVVPPIPEKVKLGRFAPELVEFRRRSLERALHKILLHPMLQRDDDLKLFLESSNLSADIHDRDARKGRVITPEYKTYFGWSQALQQYRFEDPDDWFSRQLDYMGQFEIRMKEMAEGISVLSQKRMALAAAQEQLYQTLVALSSSNLSRSVSTCFAALGDMKKRSALASTALADHEANVLGLVVYEYERMVGSVRKAFATREEVWQAWQHADDELSRVRSKYARPNDAHIDTQNHALTHAQIAHAALHTRFEEVTRLCKLEVEKLERDKVADLRKAFEDYVHKFRLVQHDLMDEWAHCESIVLRVTNKSNRVRTNMRARGEEQEYGLVYFDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAE5</accession>
    <name>A8QAE5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729237.1">
        <property type="nucleotide sequence ID" value="XM_001729185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAE5"/>
    <dbReference type="GeneID" id="5853543"/>
    <dbReference type="KEGG" id="mgl:MGL_3704"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3704"/>
    <dbReference type="InParanoid" id="A8QAE5"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="860" mass="93110" checksum="F6C49DD760579400" modified="2008-01-15" version="1">MADTLSDTTHIESSDATEKQATLVHDAGFKIKDSPQPDEAQQHGRTDSSIKEDEASESTRLSANSVPDADTVEEFNKEFASGFNQPESKSVNLAGNQLDHDAEKESAVINLTASSHEGTQNDTGLTESIKPTAASANVGNDQHDGMSRDVTRGSENPMKSNLLFRSGLDSKDEIYESQNEPEHTSLSSSVLSRDNKLDQRDDGHNFISKSCPSMRAENEKSKSLQMPAHDHEICPDQSGLSQNSGATDGTILLGSREPASDLGITQDAAKTPVTTNDDACPESDTDVLQVVNKPVKENVLSTSADSECPAPIAANHEATKHTMRQDSDDKIMLPKPRDDDSFYNKDRTVVMVKHMYEDQELRNPPASSSQVSSLEVQHGKADSPGDDSVYDGPLRRIPENLDDTHHSALVPQHDEMLDANSMTPDQPLGESTTGTESMLQDEPSKEFDLGVTQSVQDTLDQQAKTPGDSLMASVEAMTSTQSSIASPSQKTSLAERLQRATKTPPAIPPAKRGTDTPMEPDAKLDIWANKSVQDPVSIQGASTETAISQETAETSECDGDVTTRIHPELDSAGGMDRSLDYLPQDRPEHHTAASDHASLEDTAESLGATSNSSSSDDETDSNIPDLWVTSKLTAENPHEISLDQSRGINDARRPRTEHPFKEQSAAPVERTPELALQRQMENVTLASSPQAQAATPRDDSRTDIPAGDIRCVASKPAVHVSATVTGRDLPTPPPLIRPQRHTNPRSRIPPPAESTSNDAQVPAAKPPSLPPRRVRRDLKETRAVSEMPPQALLAPTQPPSLPHRMRSDAAAGENARRIVSETPGFGAARSEDISSTKSPRARRTLSDIMREADQILQEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAF6</accession>
    <name>A8QAF6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_3715</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729248.1">
        <property type="nucleotide sequence ID" value="XM_001729196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAF6"/>
    <dbReference type="FunCoup" id="A8QAF6">
        <property type="interactions" value="748"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAF6"/>
    <dbReference type="GeneID" id="5853554"/>
    <dbReference type="KEGG" id="mgl:MGL_3715"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3715"/>
    <dbReference type="InParanoid" id="A8QAF6"/>
    <dbReference type="OMA" id="FAQYVHT"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="284"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="494"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="885" mass="97397" checksum="4DBCBB0F8650F438" modified="2008-01-15" version="1">MTDASSMDAEAKKRAKRERLEAWRREQAAKKRQTPDDSTGSDKGTRQDAVASGTDASAAKRRTLGLRGTGLSHAGVGSGGGVVKPRIRLGALDDMDDDAGEAKPLRRITLDTEEDSRSRAVNEATADDPLDAYMQELESEVQRESHEHGHDGGLEVLMGDDEEPREGTETHADDDVDIDSIRAEDILALAHRGSKKKHLPAVDHAAIAYEPFRKAFYHAPDEIASMSSADAERLRVELDAMSVRGKHCPTPITKWSHCGLPVNCLDVIKKLGYVAPTPIQSQAIPAIMSGRDMIGVAKTGSGKTMAFLLPMFRHVKDQRPVESGEGPVALVMTPTRELAVQIFRDAQPFLRAFNLRGACAYGGTPISEQIGEMKKLVEVVVATPGRMIDLLTANSGRVTNMQRVTYLVLDEADRMFDLGFEPQVMKILGLIRPDRQTVLFSATFPKPMESLARKMLRHEPLEVIVGGRSVVAAEIRQIVEVRPDSSKFHRLLEILGQLYHHDEDARTLIFVDRQDAADELMHMLMKRGYPTMSLHGGKDQADRDTTLADFKAGIVPILTATSVAARGLDVKQLKLVVNYDVPNHLEDYVHRAGRTGRAGNQGTCVTFITPEQDRYAKDIVAALRASKATVPPELEALASQFKEKLQQGKAHASGSGFGGRGLERLEASRERLLQAQASIFIEDEDADPEAVAARAADETQRLNGTDIQVRTGPIPEAVRENREPVYTDADQAANQARLEAARLAGADTSKLQEVIARINSVASRRREELENSRRARDPDATKFHAIFPINDFPQKARWNVTNKETMAMLIESTGASITNKGAFYERGRDPHPGDPPKLSLLIESNESFRVEHAIREIKRLLLEGTQAYLDSESRAPSLGGRYSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAN5</accession>
    <name>A8QAN5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729006.1">
        <property type="nucleotide sequence ID" value="XM_001728954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAN5"/>
    <dbReference type="FunCoup" id="A8QAN5">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAN5"/>
    <dbReference type="GeneID" id="5853313"/>
    <dbReference type="KEGG" id="mgl:MGL_3794"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3794"/>
    <dbReference type="InParanoid" id="A8QAN5"/>
    <dbReference type="OMA" id="RPRGNAY"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="343"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="205"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="46415" checksum="D48A5CC1CA646EFA" modified="2008-01-15" version="1">MSQSVTAPNQGASSTVPNKASEVGWLFVPQYYTFMNKDPSRLHCFYTKKSTMVHGTENEDVHPSVGQQEIHQKVQSLGFQDTKVYVSNVDSQSSADGGIVIQVLGEMSNKGGKWRKFAQTFFLAQQPNGFYVLNDIFRYLNDEDVDEDDEDDEDNGAGNQTADAGAAKGAVESSETPSVSVADTPAARDATVSKETSSSHEKTSADASSPSNAPAQDTSSSAHPASQAPSSATASAAESSTAAPAQSQDELNKVSSAKAKATPAEASTAPPKPAAPKTWANLAASGANRWGNTASEARGLSETPAASAAATTPNESKSSAPGHAGKTGKPQQQQQQQQQQQHGHVFVKNVPTSQVSQDALRKALETQFGPMKECHLNMSKGFAFVEFVHADAARRAISASSNHGGVRVGEASVLVEKRRPQERGSGGGRGRGGHRGNHASHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAP5</accession>
    <name>A8QAP5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729016.1">
        <property type="nucleotide sequence ID" value="XM_001728964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAP5"/>
    <dbReference type="GeneID" id="5853323"/>
    <dbReference type="KEGG" id="mgl:MGL_3804"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3804"/>
    <dbReference type="InParanoid" id="A8QAP5"/>
    <dbReference type="OMA" id="RYIGNYL"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="58506" checksum="6F6F681E6BAA6C2B" modified="2008-01-15" version="1">MYTDEALKITYRLPDELLPTSVEIYDDDPENPHIIAQQTKMSSFEALEKLRYDPLHGLPRPEHMPTHEYEQELRNRLVRHNTRRKDQVFAPDWRELMDNCYERRLAQSGRNASSSSRDLEYLTNPAIKRTAIVMRSYQGYPWREDDILNLRAMISELSLNNPNMPYDVRILVEVKDPNLSVFTSEWDRYRVLVTSVPREFWGLVEFWSEKQLEVLYAGLPGKFINNMIAQTSYRACLMALQTFWLNHQEYDYVYNWEMDVRYIGNYLDFFEGIEEYARREPLQPGMTKYETWYMPNVPASEQIWRTPIPETSKVGEEADLITLGPIFDPRGSGWYWTHDVQNYPEGWNTHRRASIGTNMRMSRGLLEAMNVVNAEAKKSLHCEAWPTTLVLHSQLPPSHNQSFYPEAGFTYTLPLPFKGVFAPHPIYFRHDWDLHELNQLLNRQDFYEKKNENLHKDSSFYYHAQHAKELYMGWKNNPEVCRAPSMLHPIKRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAW1</accession>
    <name>A8QAW1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729053.1">
        <property type="nucleotide sequence ID" value="XM_001729001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAW1"/>
    <dbReference type="FunCoup" id="A8QAW1">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAW1"/>
    <dbReference type="GeneID" id="5853360"/>
    <dbReference type="KEGG" id="mgl:MGL_3841"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3841"/>
    <dbReference type="InParanoid" id="A8QAW1"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="33"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="465" mass="50677" checksum="DFD4B3829DC1BAFF" modified="2008-01-15" version="1">MTDAVDKLADDVQELKLDLSTLSPLSPEVIQNQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELVRNITIKLGYANAKIYRCENEKCPRPQCYRSYPSSKEPNPPCPVPGCTGKMNLLRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNEPCPQPQTSEHLAAVEIMKLQHIIILQNKVDLIREQAAEEHWKSIVSFVKGTVADGAPIVPISAQLQYNIDAVNEYIVKRVPVPIRDFSATPRLIVIRSFDVNKPGAEIDELKGGVAGGSILSGVLRLGQEIEVRPGIVTKDAEGKIHCYPIYSRIVSLLAEQNVLKFAVPGGLIGVGTKIDPTLCRADRLVGQVLGEVGKLPAIYTELEINYFLLRRLLGVKSDDKKQTKVQKLTRNEVLMVNIGSTSTGGRVMSVKADLAKVFLTSPACTEVGEKIALSRRIDKHWRLVGWGSVRRGTQLEVEGTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAZ8</accession>
    <name>A8QAZ8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SET domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729072.1">
        <property type="nucleotide sequence ID" value="XM_001729020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAZ8"/>
    <dbReference type="FunCoup" id="A8QAZ8">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAZ8"/>
    <dbReference type="GeneID" id="5853379"/>
    <dbReference type="KEGG" id="mgl:MGL_3860"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3860"/>
    <dbReference type="InParanoid" id="A8QAZ8"/>
    <dbReference type="OMA" id="INVLARW"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="46"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="483"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="659"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="80530" checksum="BD86E71078FDA703" modified="2008-01-15" version="1">MALGPALACTDESGCINRLTQVECLRDVCRCGVHCANQRFQQHAYAKVDIVKTPDKGYGLRAQTDLGRDEFVYEYIGEVINHDTFMRRMAQYKTEHIEHFYFMMLQRDEYIDATKRGGRSRFINHSCSPNCYVSKWHVGRHVRMGIFAKRRILAGEELTFNYNVDRYGNDPQPCYCGEPNCVGTLGGRTQTDVVTMDDRFITALGIADQVAQLRASLPRGKRSKILDEDFSPTLHAIAEDECARVMTVMRDATANRKMVQMLLTRVRLTDDISVHKMLVKMHGFVVMAGVLDEWVDDWELVHLALQCLEKWPLLARDKVVDSGVGLQVQQILEACKRESESEKKFEGHLSKVAMLAQYLVHKWEQLPTTFRIARKDGTEEDEDGGAWAARRRAQASSSTQASHDDTTSSAVSEELRRSLLAYRDADKNVPTAPDVPRSSRMKEEPRKKDEAQMHKNSLPSIEDIIRRANEDSEAQQKRLLQQQELELEEQKREKERKEREKKKRRAKQHDEMRGGQDMASTSASKRASPSSSESHIVHKDKRARSASAHEDTDIETLERHLRKLVGALVIKQMSKVRDQLDRERFKRHAKEVSTKSVSPLTLLLQLTQVLCDKEKRNPKTWPPRLPEGQPGLRELSEDKRKKMKIFAHEYIKKLLRHKSKAHMSADTSADLSTQPDTSVDASIDLGSPSSSTTKKPSSPSLSPPSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCA5</accession>
    <name>A8QCA5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_3987</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728820.1">
        <property type="nucleotide sequence ID" value="XM_001728768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCA5"/>
    <dbReference type="FunCoup" id="A8QCA5">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCA5"/>
    <dbReference type="GeneID" id="5853126"/>
    <dbReference type="KEGG" id="mgl:MGL_3987"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3987"/>
    <dbReference type="InParanoid" id="A8QCA5"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="68"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP41606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="475" mass="52260" checksum="C4B78B0D95494B4C" modified="2008-01-15" version="1">MCDCQNSRPSKMQRIEGEASQDVKDNHVAVDSSSAVETPARPENPALQGVQPFGASRYSDFLSNVSNFKIIESTLREGEQFANAFFDTETKIRIAKALDNFGVDCIELTSPAASEQSRKDCEAICKLGLRTKVITHIRCHMDDARIAVETGVDGVDVVMGTSKFLREYSHGKDMTYITKAAVEVINFVKSKGIEIRFSTEDSFRSDLVDLLSIYQVVDKVGVNRVGIADTVGVANPRQVYDLVRTLRGVVGCDIECHFHNDTGCAIANAYTALEAGATHVDTSVLGIGERNGIPSLGGFIARMYAADRDYVMKKYNLKALREVEDIVADAVQVQIPFNNPVTGYCAFTHKAGIHAKAILANPSTYEILRPEDFGMSRYVSIGHRLTGWNAVKSRAQQLGLDLTDEQVKAATNRIKVMADIKDQTMEDVDSVLHVFHRAIKNGQDVSHDALFDKLFEQHTRTRGQDAIAAEGEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCG4</accession>
    <name>A8QCG4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_4006</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728839.1">
        <property type="nucleotide sequence ID" value="XM_001728787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCG4"/>
    <dbReference type="FunCoup" id="A8QCG4">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="GeneID" id="5853145"/>
    <dbReference type="KEGG" id="mgl:MGL_4006"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4006"/>
    <dbReference type="InParanoid" id="A8QCG4"/>
    <dbReference type="OMA" id="AYKPPWM"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728066" description="CSC1/OSCA1-like 7TM region domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="118"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="291"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="677"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="88492" checksum="0C0CCF2D623F8B0C" modified="2008-01-15" version="1">MAGTDAMVFLVFLKLAAWLLTAIAAPLCLILVPIDVTYKNNEQNDASQNDSQGSNGFHDTFMYFTMGNVHGPRLWAHVILSYLVTVAALCMVYFAYKKVIALRQAYFSSVKYQTSYYSRALMATDLAPDIVDDASLRDTLTSAGIVYPLCEVQLGHGIDDLPQLLETQKQTVYELEYYLDRALRSKTCKRPTVRLNSWYFGHRVDAIDHYSRELDAINEKIYLARSDQTDYAPQSYGFASLAAPMYAHATAKHFSKKQPRNVKIRLASSPNDILWTNLIKSPASRKRSRHFARFLLFLLFVANVFPLLTVSIISNLSAFSPISANLETWQTYHSVSFAIFTGVLPPLITFAFSLLLPMMMRRIAMYRGVRTRQSRDLSLTSQYFTFLMATQLIIFSLISVILDLIIMILSAMHNKLSVSSAFSQISKEILDQVSKRFQFLSAYWITWIILKGYLLLFELAQVRRLSFLMIHRYLFKYNPRRIHNYTKAPHFSYWVIYAEMLFLIAIGLIYAPLAPFVTAVAAGVCWMALFVYKNQLYYVYVTKSESGGRLWSAVVKCLLAMLATMEVIVAIAIGLLQNWAKAVVCIPPIIVIGLFGWYCHAKLEPLFLWHNPSPMDLAHFQVQVYGSDREHLARQFGNVYLHKPLEKPVVDSELIHRVKEFYDGPVVSSKTNNSLELEQEPVLPLKRSRSSSSLDSSDTFDTNADPLPVIDIDSVYGDVFDPKTETQMEREANILHLPSLNKFELDQDGDAYSMVSMMPEPSSTPQAAENKIDAETGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCI3</accession>
    <name>A8QCI3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_4012</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728845.1">
        <property type="nucleotide sequence ID" value="XM_001728793.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8QCI3">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCI3"/>
    <dbReference type="GeneID" id="5853151"/>
    <dbReference type="KEGG" id="mgl:MGL_4012"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4012"/>
    <dbReference type="InParanoid" id="A8QCI3"/>
    <dbReference type="OMA" id="RWLDTMS"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="14">
        <location>
            <begin position="944"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1259"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1325"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1262"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1325"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1389"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP41631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1518" mass="170974" checksum="C675F20DD3551560" modified="2008-01-15" version="1">MSLRVCLHSAACVRRILFSCNEIKTYHYRPKCANSWTRVAKQGMVKRWATTLPSADLDHEASTTDQSTSDKSLDAPSNPVGVQLLERQVHRQLFPPTSMQIPVVDELALNVCQDHLRRHDLHASKASHLRPTSFVLPPLQGKDLGEHFWTIGRQSVHPWLEYAERLSTAQIPAPPVAETDVDTSKHWDPQSWLALDDTLRASVPLKPATFCTAHGWTKYPFLRTSEGEIAGFGEPVQVPYPDEQDSALVFDVEVLVKVSPYPVMAVAVGQQAWYSWLSPWLVQQGPRHQSPAHLIPMGPRKTSASVPRLVVAHNAGFDRACVLDEYSLHASKIRWLDTMSLHVATNGISSPQRAAWTEHTRVRAIRRLNKLFAAQRVEEDTREQIRKLLGAGNLDDKALSELRMQQLNDIAEEVQECLSENIHGLNTSLGLDNPLLQTDDDHNQVLWQDVTSQNSLADVAALHCGIHVDKGIRDVFLSSTSREEVAAQLPLLLAYCASDVSTAFSVFTKVWPAFRRNCPHPATLAGVLGLGSTFLPLDATWTNYQQQAKAKFDEMNANVVTTLKKLTYDLVEAGIQDIDRASETPAKDRWWETDPWYSQLDWSPKRPKTLDASAFVPAWWRDRVANAKTKLSARVKIVPQLLQLQCDGNWVVTDGKRWAMQCGEGTVELPGSPLSQAVRKKHVITSGGGALAEKALNAVLISSRDSDSIMRELALMIRDQGHRDQPGLTQLDWTPVPYHDPAAQAPWWPKWYWDLYDAQAEDVEVTIRTKIAPILLKIAWDGAPIFRSREHGWVYRRTHAHPCDATPLTFSHAADTALSQGIFYKLPHVNGDGSNVGNPFSKGFLPYFENGRLRSLHPSEQSAEAARAALEMNAQCSYWISARDRIEKQMVVWDGEADTCMGFDDTQMRRGMILPQVITMGTVTRRAIEKTWLTASNAKKNRIGSELKSMVKASPGWSIVGADVDSEELWICSVMGDAQFGIHGATAIGWMTLEGSKAQGTDLHSKTASILGTSRDQAKVFNYSRIYGAGIRHAMQLLLKANPSMPVDEASRRAKQLYAATKGQNTRSQKYFGRRFWYGGTESFVFNKLEEIALSEQPRTPALDCGITAALSKQFLPKTRGSAQQDYMPSRINWVVQSSGVDYLHLLITSMTHLCKTYDIEARFMLSVHDEVRYLARDSDKYRAALALQIANLWTRSMFAFKLNMGDVPESCAFFAAVDIDHVLRKEVDDPCVTPSQWEPIEPGESLDIHTILERTNGSLFRDGRPMPRPSSELHESPACTQDPGWPAYVPSTQQHRCLGEAGLLYLQAQASADIDEIRALHNRLQRQHARHPQPRRQRATLLHMPSVRTVTTSAEKSAAAHQRLQQHSTRKTRQMESLLALEAMLPKKQSHRDPKRKKRKNQVRAPMSKSRSRGSPQPKSTRPMHLSGALLPPSLFNKPMLRYKPYQPAQMNMMISSRRRARNKRLQRWDEVQEIKFLAETEAQARVRDGFFDRVNEWCKSDTQLEWLTYRRAICAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCM1</accession>
    <name>A8QCM1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_4024</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728857.1">
        <property type="nucleotide sequence ID" value="XM_001728805.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8QCM1">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCM1"/>
    <dbReference type="GeneID" id="5853163"/>
    <dbReference type="KEGG" id="mgl:MGL_4024"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4024"/>
    <dbReference type="InParanoid" id="A8QCM1"/>
    <dbReference type="OMA" id="VASWPWF"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="698"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="892"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1137"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1232"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1268"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1291"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1308"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1336"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1376"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1409"/>
            <end position="1418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1426" mass="160386" checksum="02285B170AFA0D40" modified="2008-01-15" version="1">MKEEDIFLGIFAYIEHLFSKIRPRKVFFLAIDGVAPRAKMNQQRSRRFRTAQEAKENVEKAIRRGEELPESPPFDSNCITPGTSFMRKLSQQLEYFVAKKVSEDSDWRGVEVILSGHEACGEGEHKIMEFIRTIKAQPGYNPNTRHCLYGLDADLIMLGLLSHDPHFALLREQVTFGPRRARRSVGVESQTFYLLHISLLREYLELEFASLRDKLPFAFDLEKIIDDYILLHLFVGNDFLPHLPGLQINDGAIELLFRVYEKVLPQAGGYLNEQGVLRPERLQLVINQLFQLERDRFVHQHMPQLEQKTKARRTRELKNYRVGAPKYIRRAHHNFVLNVKSLLVDFFADPKNAPWEFMVVVRPESDLVQFAQELAEKLDMVFYFEKDESYESPTDDAECYMSLKPSMIRQVRIPIPDSIDALEEKKKGMLATLESHLSLPIERKRHDPFASSRNQTLSEEESEREEQIAEEREREKEIDDALKEWKADYYHTKMGIKYNDPDAIQDIVYNYIEGMQWVLYYYYEGNASWGWFYRYHYAPQVSDLKNISDFTFQFNKGRPFLPFEQLMGVLPPLSKDLIPPAFQPLMTDPSSPILDFYPTKYESDMNGKKNSWEAVVKIPFIDEERLLHALQLREGGLTAEERQRNTLGVPLRFCYDNTFTRHVPSSLPGFLPDMPDNHTRILTYALPSMEGKSFVKTLPEGVHLGLDAMPGFPSIKTLPHTHTLRKYGVNVHGNASNDASMMLSVGRRDDQPDDLRSLADAMIGHTTYIHWPYLFEGLVVAVSDGSQEFRAHWQDADVVTRTTPAADMKTSFSKHVQSVLQYYGKRCGVLLHDVTALLHVRPLKGLSHGYDGSIMKQYEPSPEHEVVYPLPLMVNQVRRPDSRFLERAPMTVSEEFPDGTKVFFLGMPGFGCPARVIGSASELITVELAFLSDMAQEQAIIRKLVQQRATDTYFSSPAIAQQLHMSSLALAKLTSSITVLFKEQKLNIGLNLKFEAKSRKVLGYSRRTHLGWEFSARAVLLIKDVLDQFPELKSALARRLGDGEFYKAEDVFPRDTDKRIAAVRAWQKEHGLRDLEDVPLYVDRLERPIISTLESAVSILANRRLESSGAIKRQILRGLPRGALLKPEQARYRVPEQTFELGDRVINVLDFGSIPLAAKGTVVGIGAKSIDVVFDAPFLTGHSLGGICSPYRGATLGLASVLNLSTPQIATRWGEQNEGQADLTPLQRTLKAQIHQQMTSPAPSKGSLFYQPAPPHAQSKPTASGHVSRASRSRAGIGASSATTTTTLSSKQGVSAATSHLASLSIRPPAPASNPWQRPPPRPAVPRPHAPDAAPSTKNGTRTTPGQTARPATRGPSVRPPAGPRPPRPHAPRPPKAGSGPKGSSGTSNQPGQPVPRPPKPQNKGPSQRPRRGPKGAARKPPNAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD10</accession>
    <name>A8QD10_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_4078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728743.1">
        <property type="nucleotide sequence ID" value="XM_001728691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD10"/>
    <dbReference type="STRING" id="425265.A8QD10"/>
    <dbReference type="GeneID" id="5853104"/>
    <dbReference type="KEGG" id="mgl:MGL_4078"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4078"/>
    <dbReference type="InParanoid" id="A8QD10"/>
    <dbReference type="OMA" id="HEGEIAW"/>
    <dbReference type="OrthoDB" id="3362485at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="261" mass="29054" checksum="4ADC79A541C2FC7C" modified="2008-01-15" version="1">MNEGSSSAAHEGEIAWFHAGTDLSRSHALDICAELVGHVTHTEKKLVLDAFQSSLAVPWCISNQYYQAHVHHVYLEEFNQIGGRPAVVLLVRHDMSQDAHQQVLDRLRSEQEVDVALVLGVRMDNETPGGSKEVLSGPDVDELDAMYGSTGWEYMELIPDAPKRISEALMAHSSWPGMQLTEKGTSKGGDENEDEMGEFQTFQDPFLAAVRDASDNTEDDPLMEMFEQIHTKLDYVKSLPYGPAREREAARVALAFQRSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD64</accession>
    <name>A8QD64_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_4132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728797.1">
        <property type="nucleotide sequence ID" value="XM_001728745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD64"/>
    <dbReference type="STRING" id="425265.A8QD64"/>
    <dbReference type="GeneID" id="5853037"/>
    <dbReference type="KEGG" id="mgl:MGL_4132"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4132"/>
    <dbReference type="InParanoid" id="A8QD64"/>
    <dbReference type="OMA" id="YAPKCSV"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09396">
        <property type="entry name" value="LIM_DA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="402"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="534"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="605" mass="65245" checksum="B1C0DE015F82AD89" modified="2008-01-15" version="1">MSVSQRPLPQPSGSFAASSPSAYDLFHRGHKPVRRTLPQAEATEELGAHRFGGHADEDLPPPVPPKPEKSHERPRAPVLPHMDFHEHTTSRNRETASPSFKIPRKRPLPPFPAMDTSPTTTPTSSPHRPLPSVRHGARPLPMPGASHVPISMGWVAGPPDSPSRPWSMYSFPPAPAQVQAQEQVPVAPWPSTPPPAHHLPLSQPPPLPPRSVPPKPPSLERVDSPPPSLPVDSPRRAMPVATAATPAGTTLSACSQPPASEATGSLKLTPSTSTPSGSATSACSAIKPSASAPSSSSTLATAPPQHGEHDSSRTHPSLPEHTSDVVPANAAASSASSAKPPIPLIMLDGHVMTDDMMDPSSPDVSHNVATSDEMPAPQHASSSSAADRETTHGPYISEGIHSMCHRCGRWIGGYMVHAMGHAWHARCFTCAHCQTPLEHVSFYEHDGEPYCHLDFHELFSRRCYHCQTPIVDERFVTVDAFGDVRSYHEAHFFCAQCGDPFVEQKDSDESTTSECSRPFFVHGRHAYCESCHRPRCQACKKPVGDEHVQALRAVWHPECFVCTRCRKPCQGATFVAPDGSPCDFDCYQAWVRGGRGGPAPPAFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD79</accession>
    <name>A8QD79_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_4147</name>
        <name evidence="15" type="ORF">MGL_4153</name>
        <name evidence="16" type="ORF">MGL_4159</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
            <strain evidence="14">CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728668.1">
        <property type="nucleotide sequence ID" value="XM_001728616.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728674.1">
        <property type="nucleotide sequence ID" value="XM_001728622.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728680.1">
        <property type="nucleotide sequence ID" value="XM_001728628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD79"/>
    <dbReference type="STRING" id="425265.A8QD79"/>
    <dbReference type="GeneID" id="5852970"/>
    <dbReference type="GeneID" id="5852974"/>
    <dbReference type="GeneID" id="5852984"/>
    <dbReference type="KEGG" id="mgl:MGL_4147"/>
    <dbReference type="KEGG" id="mgl:MGL_4153"/>
    <dbReference type="KEGG" id="mgl:MGL_4159"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4147"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4153"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4159"/>
    <dbReference type="InParanoid" id="A8QD79"/>
    <dbReference type="OMA" id="SRRINEN"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="11">
        <location>
            <begin position="162"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="12">
        <location>
            <begin position="349"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP41454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP41460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP41466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="58943" checksum="F0391A0BC0E25D2D" modified="2008-01-15" version="1">MPGLSWIGNANELGAAYAADGYSRVNGFGVLLTTWGVGELSALNGVAGAYAERIPLLHIIGSPPTIQAKKRLPIHHSFADGDFGVYKRISEPVSTVMEEISETGQADTIDHVLRCALQDRRPAYLSIPTDMVFREISGAPLLFPLVEQSRGPISPLDEEIARRILTYIEAAQCPVIIADVRVRQYGCSEALSKLLDTLQLPTFDTPLSKGLVDETAPSFMGTYIGASSNPEVASRLGEADLVVRFGYLETDSNTGGFSAKIDPHKLIDLNVKQVQFFDGPEQSVSMMIHILEHLSAHVSRCPISKQAPVFDSRNNIVSNTDSDSMITQPHLWAKISQFLKPNDVVICDTGTASFGVTDIRLPRDSKLLSQMLYNSIGWSVGAAVGAAKALQEQTIGKLPRRLIIIVGDGALQTTVQELSTLLRIRASNVIIIVLNNDGYTIERALHGAFRQYNDIMPWNYSRLLKDFGADQNERNSIVAKTAKDVQCAFDDFTASSTQSIMLLEVYLARCDYPRILSKLGQVSRERNSYGYAPEYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDD3</accession>
    <name>A8QDD3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 16">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 16">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 16">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_4188</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 16"/>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728709.1">
        <property type="nucleotide sequence ID" value="XM_001728657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDD3"/>
    <dbReference type="FunCoup" id="A8QDD3">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDD3"/>
    <dbReference type="GeneID" id="5853018"/>
    <dbReference type="KEGG" id="mgl:MGL_4188"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4188"/>
    <dbReference type="InParanoid" id="A8QDD3"/>
    <dbReference type="OMA" id="KDYYVCE"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017075">
        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="18">
        <location>
            <begin position="41"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="19">
        <location>
            <begin position="245"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="17">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP41495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="423" mass="48461" checksum="BF085DF9DC58E600" modified="2008-01-15" version="1">MESIIPDVPGVPVSDPMQLEFLRDHVRNLCNLRSTRFPGSQPVSFNKSSLDVLLHEDFWVCEKSDGQRVLVLIVVPPVTGIQEVYLIDRKNVYYRVHGIYFPPLPRGTGTMMEPFPLTNTLLDGELVVDTLAKGQTKLRLLLFDCLVIDSMNITNRPLSRRYASLQMQLFPAFRKFMQGHPDLQMMLPFEIQVKPMDLAYGISAVIEHKIPHLLHGNDGLIFTSFESPYVFGTNSKILKWKPPHENTIDFMLRLRFPPDFEADKSGNTPDYCAKPLFQLWQHESGDVHVPFDWLDMDDDEWERWKESGQQLDERIAECAWHPPASGDESISTWHIKRLRDDKITANHKTTISRILQSVRDGVSEEELISLVPAIREAWKTPERESHRAELFGPSRQVRRKSCFKGLGGPGAPLVRGGMPNIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8QE11</accession>
    <name>A8QE11_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_4249</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000025">
        <property type="protein sequence ID" value="EDP41394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728608.1">
        <property type="nucleotide sequence ID" value="XM_001728556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QE11"/>
    <dbReference type="FunCoup" id="A8QE11">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QE11"/>
    <dbReference type="GeneID" id="5852916"/>
    <dbReference type="KEGG" id="mgl:MGL_4249"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4249"/>
    <dbReference type="InParanoid" id="A8QE11"/>
    <dbReference type="OMA" id="ARFWKQF"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="152"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="298"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP41394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="402" mass="44211" checksum="3074452DBABA0844" modified="2008-01-15" version="1">MSSMAAASLDSIAAGEQLMQLDQAITLTLQEIDENFSQAHQIVTSRILPAIREYESSCSQTWQSARFWKQFFEASAQVSLSQQPFEEVDGSINNCSDTTENQVLAKGSHDDITHVTQESGPMASPPRMSTSVYAYSNDSSQLDTPFERLKRDVEASRQDDLNKAPERPLKEADMSMPTDSSVILSDIPKSSSPTKLRRRSSARPRISVVASRDGQPTTNPFTTGDTSKSWNGIADLRTTPLRSNQHYRDESGDTSLALPDGMSPPVTMQFSVPQSKYKKTPAKEAARRVVHDLLRSVGGDEGDLTLNDVSPSTAASQTTQRKSVVGTPLSKETHHRRDSLPTPPTITKVYESTERSNGRAEAIHSRANLLLDSGEGMFENTFVGEDEESDEDDEDEEEDTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8QEL3</accession>
    <name>A8QEL3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_4272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000036">
        <property type="protein sequence ID" value="EDP41374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728588.1">
        <property type="nucleotide sequence ID" value="XM_001728536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QEL3"/>
    <dbReference type="GeneID" id="5852896"/>
    <dbReference type="KEGG" id="mgl:MGL_4272"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4272"/>
    <dbReference type="InParanoid" id="A8QEL3"/>
    <dbReference type="OrthoDB" id="4009151at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047741">
        <property type="entry name" value="DIP1984-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20935">
        <property type="entry name" value="DUF6847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="58" mass="6775" checksum="265885A8F013E737" modified="2008-01-15" version="1">MLLAEALAERAKAQRRYEQLMQRLLRVVRVQEGNQPVEEPNELLVSANGILDRMDWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR36</accession>
    <name>A8PR36_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732817.1">
        <property type="nucleotide sequence ID" value="XM_001732765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR36"/>
    <dbReference type="STRING" id="425265.A8PR36"/>
    <dbReference type="GeneID" id="5857123"/>
    <dbReference type="KEGG" id="mgl:MGL_0592"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0592"/>
    <dbReference type="InParanoid" id="A8PR36"/>
    <dbReference type="OMA" id="DSPAWHY"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="138"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="339" mass="36923" checksum="F540B2962264EBBC" modified="2008-01-15" version="1">MPTLLRVSSALTDSDAKMNGVSGPDWDLILDETKSLSPSEASERPWEKDERDVTLFGSFALDDSVDIVACSSCKKPVLREAFPYHTQNCTMARSIKDGSLSPSVLKSSVPSTGDAAAGGESLLSQDAAAARRKNMGGGKKNRGPINLDRQCGVINNKGLPCSRSLTCKSHSMGAKRNVPGRSQPYDILLFEWQKATNPAFVARLEEKERQIAAMKSASQANKEKKRKAAHEKRADPTEREASGSSSRVAVDHASDMYKAGATFQEVDRDLFSTLHSIHSVAARERTNILPMATRSLAGQYTTRTKRFRVLRQFLAQGLSGTAHVRARINEVAEGSRDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRK6</accession>
    <name>A8PRK6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732299.1">
        <property type="nucleotide sequence ID" value="XM_001732247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRK6"/>
    <dbReference type="STRING" id="425265.A8PRK6"/>
    <dbReference type="GeneID" id="5856605"/>
    <dbReference type="KEGG" id="mgl:MGL_0074"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0074"/>
    <dbReference type="InParanoid" id="A8PRK6"/>
    <dbReference type="OMA" id="ELENEYC"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="531"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="65854" checksum="818FF2E25B876015" modified="2008-01-15" version="1">MSTNAHIAKRAQESSIDALVDKFSTVLDTSLILAIANEPGQSHGEAGKILEELAKAVPPESVPAAQRVGFDPSSTEFTLLFLQQSFPDVPSERLETALATSDGDLDAVMDEFLVERMLLWESTPCQDDSTRNHGGHRGGLNFDALAEGLSSKRSGKSKKNKTTKRTTGPVTVSLTDQRSPHHLYYNSRTSHSEKASTSAAPGSVDTTGLTDEEIARKLQNAERDAADAASVPVADQQWLLVSSSLSQLAVLLGVPQPRIQSLFHQSSFNLHVTFGRAIEAALMNPAAQRVAQTLDFQITSSELASITGHSEYDVRRLLQATQGNQDAVLDLLQLQSVIQQAADGTSCRTDILDPSGRILYEKSNAERSVMAQSEHKKVTGLAPRWLPSYTTSYAGRATQTPSATSALAPAGSVAAAVTLPASASRVEAPAASTSADDATGYTNEECRELASEYRMRRNEALQKAAQSVRQSRGSGIGGAAMVYAEDARKYDIEARRWQLRASCALVEQRRLAADVNTATRGTIKEGGSDCIDLHGLTVHEALMAVSHNIARWQSTPLGEAKVRAPLEIVTGRGMHSRHNVSVLRPAIIRYLTQRGFKVDATSDAGVLYVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRT5</accession>
    <name>A8PRT5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0124</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732349.1">
        <property type="nucleotide sequence ID" value="XM_001732297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRT5"/>
    <dbReference type="GeneID" id="5856655"/>
    <dbReference type="KEGG" id="mgl:MGL_0124"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0124"/>
    <dbReference type="InParanoid" id="A8PRT5"/>
    <dbReference type="OMA" id="VYRESGW"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="107"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37351" checksum="9F46876F856F6CD8" modified="2008-01-15" version="1">MPREQLEWRERAKGFVGGVVSGLTKLAIGHPFDTVKIRLQCDPASYRGPMACLRSLVQNESIWALYKGCIPPAFGWMVTDSVLLGSLHTYRRMLMRWSPRHQRDGKLPVAYQGLAGVGAGWTNSFLTAPVELLKTKLQMQKETFSSYGKAHGAEFSSTWDCVRQVVRYTGVRGLWRALPATLLFRTSFGPMFASYEVFQRQLGAWASKHREDASWMYAWLLSPASVTFFAGGLAAEVFWFTAYPADVIKNRIMAVSLHEPRYASGTRGMWQAAVELWTPPNMRESECGVLGLPRRLRRIYTGYLTCALRAFPTNAGALLAFETAMYLMQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSK2</accession>
    <name>A8PSK2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732497.1">
        <property type="nucleotide sequence ID" value="XM_001732445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSK2"/>
    <dbReference type="FunCoup" id="A8PSK2">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSK2"/>
    <dbReference type="GeneID" id="5856803"/>
    <dbReference type="KEGG" id="mgl:MGL_0272"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0272"/>
    <dbReference type="InParanoid" id="A8PSK2"/>
    <dbReference type="OMA" id="QWEVFQI"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="154" mass="18304" checksum="FE1847F25D294D53" modified="2008-01-15" version="1">MPRIRTSRTRPPPDGFEDIEPILEEYETKMRDAENESQDGKRKAEGVWGIMRITHIRSRYIYDLYYKREAISRELYDWLLEQGYADAALIAKWKRTGYEKLCCVRCIQARVVVAAVHLIKQFTLTNFCRKIVDAENCDQFMDFILRAQQLLFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSS0</accession>
    <name>A8PSS0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732531.1">
        <property type="nucleotide sequence ID" value="XM_001732479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSS0"/>
    <dbReference type="STRING" id="425265.A8PSS0"/>
    <dbReference type="GeneID" id="5856837"/>
    <dbReference type="KEGG" id="mgl:MGL_0306"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0306"/>
    <dbReference type="InParanoid" id="A8PSS0"/>
    <dbReference type="OMA" id="EKHAIGF"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="107" mass="12486" checksum="F3447E7E1355B063" modified="2008-01-15" version="1">MMQSISRFFYGPGKEERVREVQRRLRQEQRSLDREIRQIDQAVMKVKADVKRLARKGDVRNATVLAKEVVRSTKHRTRLVTSKSQLNSISLQLQQQLCTYPGACARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSU3</accession>
    <name>A8PSU3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732542.1">
        <property type="nucleotide sequence ID" value="XM_001732490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSU3"/>
    <dbReference type="STRING" id="425265.A8PSU3"/>
    <dbReference type="GeneID" id="5856848"/>
    <dbReference type="KEGG" id="mgl:MGL_0317"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0317"/>
    <dbReference type="InParanoid" id="A8PSU3"/>
    <dbReference type="OMA" id="MPPDERY"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="66"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="326" mass="36091" checksum="E170DFD4B4499B7F" modified="2008-01-15" version="1">MLGPPAEFLISFGARFVPCMRSVPGLPPTNMIPCLKESTSSQQKFMKDQMCSLAHICGLDDPKNPDQGYRFVSAIFVHAGIVHILFNLIVLLTLCCQIEKLIGTIAYAIVFMAGGIGGNLLGGNFGLIGQPALGASGAVYTCISFEMIDLIYNWKYEIKPKTRLTVSIIFAVLGLALGLLPGLDNFSHIGGFCVGILGGMVFAPSIHSTKTHMFINWLCRLIGMGLLIAFIVALVLNFYRNDDPATACKWCRYLSCLPMFDACRGYGTYYELGTYAYSHLRYINYDFRWRFYNELATKKRLPSSHYLSTSPFLSPLFCDLLGILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT04</accession>
    <name>A8PT04_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_0346</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732571.1">
        <property type="nucleotide sequence ID" value="XM_001732519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT04"/>
    <dbReference type="FunCoup" id="A8PT04">
        <property type="interactions" value="601"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT04"/>
    <dbReference type="GeneID" id="5856877"/>
    <dbReference type="KEGG" id="mgl:MGL_0346"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0346"/>
    <dbReference type="InParanoid" id="A8PT04"/>
    <dbReference type="OMA" id="WQTMGIL"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.30:FF:000001">
        <property type="entry name" value="DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="7"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP45357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="837" mass="95784" checksum="27CE820383F811A7" modified="2008-01-15" version="1">MKFYIDDLPVLFPYPKIYPEQYSYMVDLKRTLDVKGHGVLEMPSGTGKTVSLLSLIISYQRFYPGSRKLVYCSRTVSEIEKALAELKRLMAYRAKYNTKKQLSDGIEPMDVDSEDIQGQMEDILALGLSSRKNMCVHPTVSQERKGKVVDARCRDMTSAWACEKGRQDPGSVELCDFHEELGKLEPGHLVPPGVWTIEELIEYSKDKGICPYFAVRRMMPFCDIIIYSFHYLLDPKVAEQVSKEISKDAIVVFDEAHNIDNVCIESLSIDLTRPILDNAYRCVNQLADKVDEVKKVDSARLQDEYVRLVEGLQQQSDDREAESFMANPVLPDDLLQEAIPGNIRRAEHFVAFLRRFVEYLKTRMRVLHVVAETPASFLQHLKEITFIERKPLRFCAERLRMLVQTLELTRLDEYSALQTVAFFATLVSTYDKGFLLILEPFETEQATVPNPIFHFTCLDASLAIAPVFERFSSVIITSGTISPLDMYPKMLRFDTVVQESYTMTLTRQCFLPLVITRGSDQVAISSRFEVRNDPSVVRNYGNILIEYSRCIPDGIVAFFPSYLYMESIVAAWHDMGILDEVWRHKLVFIETPDAPETSIALENYRRACDNGRGAILLSVARGKVSEGIDFDHNYGRAVIMFGVPYQYTESRILKARLEFLRDNFRIKENDFLTFDAMRHAAQCVGRVLRGKSDYGLMIFADKRFARSDKRAKLPKWIAQYIEPVFSNLSTDMAIVESKRFMRTMGQPYPAGKNGISLWDLEDIERRQQKERDAFERLLQQDSDDWVAKHQHEVRMTSDQDYDGSIPAANAAASVHELADDFDAEFGTGAELTQVSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTE2</accession>
    <name>A8PTE2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732635.1">
        <property type="nucleotide sequence ID" value="XM_001732583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTE2"/>
    <dbReference type="FunCoup" id="A8PTE2">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTE2"/>
    <dbReference type="GeneID" id="5856941"/>
    <dbReference type="KEGG" id="mgl:MGL_0410"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0410"/>
    <dbReference type="InParanoid" id="A8PTE2"/>
    <dbReference type="OMA" id="LFEWSLH"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="176"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="636" mass="69099" checksum="46A8A64E3A0A0A9D" modified="2008-01-15" version="1">MPASQPTNEARPDENKENIAPIRHVTPTVLVEEAQTYQANEAIAMRTRRRMAHAQHARPMTPIPTTPRKRRILSPPTSSSSSPSSSEQAHTPSRKRTKTEHESGSVRDAPPAPVQPTPPATPTRMPNVYAQARALLRTEVLVGRDMERARLHAFLDASLSSSDTHVREQVSGCLHISGMPGTGKTALVRDVLRERMDATHIYINCIGIAHPQEAAQRIAAALDVPDLTAIGRAPAQSRPLIVVLDEMDHWLHVYAHQDILQRIFCLPKQLAGKVPMALVGIANSLDLTERFVPVVRSKGVKPDVLHFAPMQADQVLALLEARLADMPGLFGRAALQLLARKLTASSGDIRRALDTCRQALDLAENEFFQQQQQRQHNSQPASTTQPTPVSVTPTHILRVLAHMAGHAQSARVRSLGVHAKLLLLTWVVLQEHAEAGLFKSGGTTRGDGGVCLSDLEAAYARMLEQDAAFVTPLGGSELLDVLERLEVQGLVRIWSDVGGGSMQQTFARSSNVSRTASSSSSSSSSAGHACGSGNSHAAKRFSPSGKRAAARQMLSTNRRMAPTLERECIVRALTAGAVTGAESTHTPTVVDAMSRLLQRAELDIARQTKWRSESEERDRTRREELGGGRRAIAGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTG9</accession>
    <name>A8PTG9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732648.1">
        <property type="nucleotide sequence ID" value="XM_001732596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTG9"/>
    <dbReference type="GeneID" id="5856954"/>
    <dbReference type="KEGG" id="mgl:MGL_0423"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0423"/>
    <dbReference type="InParanoid" id="A8PTG9"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="478" mass="53839" checksum="4EC381489713008B" modified="2008-01-15" version="1">MLIQSDHPTIAFRLVYPTLLCATNDGLLQEFDLPSRTLVQATSLEGTVNDGGNVNYIDMDDHFWFVVGDGHCAISVIDRRTHHVVWTINKHLRLYGAPTCYVPELLPYPTVPRFQQRRLYPMPAPALLQPPHEHMPNVIGVQSDRWLAVHPDKDTDTLVVLAYDAILLLIGYQAHLLHDATPKLVYYSFPPLPLVSERLNQASVRWAMGKNWCEELSADMPPQLTVHNGRAVVVHGIVTMLDLRVPSSLAFRRDKPSFDSHNEPPSFSVFQWSDVPVEGEINPFVNCSCVQMDQSGIYCVARQCLDMELDVDHTRLSDEYQETCNAKDASMVTAFRFDSASKPAFRYISRRVVEEALDSLIDELSHVPDPENDDRWVPFLVDGERLHAVDQDVVDSENAEALDMEAVDSESGEASSQPDPSVDMELIEAVRAEADRLETLRDREEDEQTRHVYALHASALREHAQLIGGDHDSDSPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTI3</accession>
    <name>A8PTI3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732654.1">
        <property type="nucleotide sequence ID" value="XM_001732602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTI3"/>
    <dbReference type="FunCoup" id="A8PTI3">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTI3"/>
    <dbReference type="GeneID" id="5856960"/>
    <dbReference type="KEGG" id="mgl:MGL_0429"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0429"/>
    <dbReference type="InParanoid" id="A8PTI3"/>
    <dbReference type="OMA" id="KWGGGLM"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="174" mass="19037" checksum="D389637018EABBD4" modified="2008-01-15" version="1">MNKYRPESKQEKKARLDAVAKEVAAGNKVDPKADGKKPLFVKYGLNHCVALIEAKKANLVVIADDVDPIELVVFIPALCRKMGIPYVIVKSSSRLGAVVHLKRTAIAVIQDVRSEDERELADLVSAAKANYLDKYDVARRHWGGGIRGNKSVEKLRKRAKAAGHSPATVAKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTT4</accession>
    <name>A8PTT4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ornithine decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0475</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732700.1">
        <property type="nucleotide sequence ID" value="XM_001732648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTT4"/>
    <dbReference type="FunCoup" id="A8PTT4">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTT4"/>
    <dbReference type="GeneID" id="5857006"/>
    <dbReference type="KEGG" id="mgl:MGL_0475"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0475"/>
    <dbReference type="InParanoid" id="A8PTT4"/>
    <dbReference type="OMA" id="SFFVCDL"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="12">
        <location>
            <begin position="66"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="13">
        <location>
            <begin position="71"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="493" mass="55061" checksum="1DECA301079480BF" modified="2008-01-15" version="1">MFVSQMLNDARSLTPPPDNVEELVAQPISKTTLGMPLYRGSTAQQFKAVLDKIDVDECDADGENAFYVADLATIYRQYVRWRRELPRIIPFYAVKCNPEPIVLHLLAALGLGFDCASNGEIQTILDMGVSPSRIIYANPCKASSFVRRAAAQNICLTTFDNVDELYKMKRFHPESKLVVRILTDDSKSVCQLGIKFGAPLADVPRLLSKARELDLDVVGVSFHVGSGCFDPEAYRDALYRSRQAFDMGREYGYTFDLLDIGGGFEHHNFEAIAKVVRSALDDYFPDEAFAPGGSRMTERPKGLRVIAEPGRYFVYRAFSLATNIIARRQSEEDNSDAVRQDGQGGADDGRPKAMYYQNDGTYGAFNCILFDHQQVHPKVLSMQRDFVYERESSVPELAQDQWRPCSVWGPTCDSMDCIMRQTRLPRALDVGDWLVYENMGAYTLCASSTFNGLARAQVRYTIGCDAMEQDGAPFTVISLLESNGVVSELDVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTT8</accession>
    <name>A8PTT8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0477</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732702.1">
        <property type="nucleotide sequence ID" value="XM_001732650.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTT8"/>
    <dbReference type="GeneID" id="5857008"/>
    <dbReference type="KEGG" id="mgl:MGL_0477"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0477"/>
    <dbReference type="InParanoid" id="A8PTT8"/>
    <dbReference type="OMA" id="DEARHEC"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="125"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="489"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="615"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="765"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="930"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1082"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1207"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1265"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1308"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1407"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1762"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="765"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="858"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="945"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="978"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1034"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1082"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1106"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1131"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1308"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1319"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1442"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1459"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1483"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1537"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1595"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1762"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP45488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1855" mass="197946" checksum="66C885C6F5741977" modified="2008-01-15" version="1">MTALDPLTGVPPPRASRPASALRNVAQPLQTATNTLGTRKRAKDMAAIFDKRQAPHSREAPRVGAAPSLRMQQAGRRGPHPSEIHAAPPITTAQVHPVEPASRPQTRLEREKKRHYNDPPNVGPWRLGKLIGQGASGRVRLAMHSRTQQLAAVKIIPKQMLINSRMSLRDLSAKQDKLTLGIEREIVIMKLIEHPNLLGLWDVYETSKELFLVMEYVAGGELFDYLVARGRLQPYEARQYFRQIIFGVDYCHTFSICHRDLKPENLLLDGSRTVVKIADFGMAALQPTEKMLETSCGSPHYASPEIVSGMTYDGTASDIWSCGIILFALLCGRLPFDDPNIQVLLGKVRAGRFAMPSHLDPSVRDLIGRMLQVDPKKRATMREICSHPWFTDNGRLSSKNPVTTEISTLSNEPIRLAEIDPDILGNLSTLWPELTHEQIIRRLLQSGQNWQKTFYMLLVIHRDSHGTDDEDEEAEDLDEDEQLQLKQTQNDMKQPAPIVHSPSPPEPSRPSTMITSGPTMTKTQPTPSSHVAPPIMPVSMGAAPECVTPSSAIATDATLHASHLPQARESLDERAPAPVVTPVGAPAAAQLTSTPPREVGRRSNVWMPDVSMGSTAASMSVDEERTTGPSTIAKGTLAARPPAPAENTASAWLMEQVRAEHARAEQLRNEHLEAERRKMEQLKAERMRTEQLRVEQAQVEQIRIEKAKTEQLRVEQEKAEQARIERVRAEQLKAQQEKAEQARIERARAEQLKAQQEKAEQARVERIRAEQRRSEQEKAEQARFEQARAEQARAEHAKDGVTSAEQARNRPPSSLDKSDMARMSSKRPSSREDGPGRRLSTLFSIPFAGRKPSLASIRHSSGHNARISSDTSRPSSALGSIPPSTMNERSSQALFSTGTLEPTLRSAESTGARKPVPTVEALEKTMQTAQQMTDVSKSVEPMEISESHETSRDRDTVHCATQQSTGSQAQAPYAHTVPSINAPTQPDKTSASHSSAVPTILAHPPSSNAIARPAPAITGLSSSPMTGGWKQRLPSLSSPEPNSRSTSQGSREGDESLMRMFMREIADELDSLDAMSTSLGMPTCARTSQNSAAPAMGSSQPVAPGTSAMDVSGSSASASASTSTSRPMTSLATTVTANSSAQPSDVSTRSGTDTSFGSQNRYDDANEESLLVTSVEPPRTSLGQHTRVYTPVYAAFAKYTNQIQAPEPQLQQQQQHKPDAPTLPVRPRTNETRAHAPGMPQIRQPIGGRDMPGEVRQSAVADANTPISSTLPTHPLSPPFPPHASSTIPSTFKPANIVPPPVELVDPSRAPATSASAAQRVSNSPMPMASATTRPASATGMLPSVMSPTTSYVPNMVPERDRAQTALGTVPVPAGTNGISSPTGPMASPLGGFVPGSRAGSGPVVIPTSPTSAAPATRLPSPIPARHPASPSVVPHAPDAASSVRPVTSTPVTTIRPSGPVPPGRPASPLPTARPVSTSPAGFVPAASPSAARPSVPFSGGRTPVPVSTSPRPASPVSATVPSSPPARTRLSGPLNASAGTAPAAGPAGRSTSPTLGLRPSSPSPTPAAASRPSSALGGPPRPKSPFGLAKRPSSLASPKPTLSSGRTASGSTGQSSIRPRRSLMGTLRGEGEPMGLGVDIVGIEQQSHAHIPRPASPIGGDAPLSIGAKHSWFHGLLPKRQMHVLMSVENLTKTKVTCESLLVQMGATILASSRAQSSLPLTQQGPSQYLLERIRDPQSGKSISCKPMRFRLEYTILPVRSQASSTPSTANGGGNMQGNALPTSPGMPGFDPRSAQGRSMSPVLGGGGGGGAASTASPSFATSVTWTHEKGSLTTFRLFMDKVRGAWTLDTTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTU7</accession>
    <name>A8PTU7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ESCRT-II complex subunit VPS25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732706.1">
        <property type="nucleotide sequence ID" value="XM_001732654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTU7"/>
    <dbReference type="FunCoup" id="A8PTU7">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTU7"/>
    <dbReference type="GeneID" id="5857012"/>
    <dbReference type="KEGG" id="mgl:MGL_0481"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0481"/>
    <dbReference type="InParanoid" id="A8PTU7"/>
    <dbReference type="OMA" id="TRCLIMW"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25217" checksum="95CECCB7A6255C37" modified="2008-01-15" version="1">MSQDDTPFAFPGVHEFAPFYTLQPNPETAAIQVDLWARLILSFCAAHHRFQLEVGGAWERESDLFCHRGLDRALSPDTVRLIFAYMVEKGRAAYDPPLPRGYKVPRVGQVDADRRMHALSVAGLRTLPALQVEPGSKIWVYWNTPTEWGDQLYEWVKQTGQNRSVLTLYELQQSTFVQREQLPPAMLMRALETLVARKCAQIFEGTEPTDGGDHENLGVKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTZ3</accession>
    <name>A8PTZ3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732727.1">
        <property type="nucleotide sequence ID" value="XM_001732675.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PTZ3">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTZ3"/>
    <dbReference type="GeneID" id="5857033"/>
    <dbReference type="KEGG" id="mgl:MGL_0502"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0502"/>
    <dbReference type="InParanoid" id="A8PTZ3"/>
    <dbReference type="OMA" id="AFICYMI"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="694"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="759"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="861"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1284"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1357"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1405"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1429"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1558"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="249"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="942"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="902"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1662"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="913"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1744"/>
            <end position="1768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1798" mass="201021" checksum="CAD66EB772FE4720" modified="2008-01-15" version="1">MPRSEGLGLDPPHDIYPPVSGTNEPSPEGDNPLHSVVHMTDSPVAQPPSMNMVMSRGDMLNTPQGAYYGHDGMVTSPSSPIITAGNGTPKELYGGYQRRSRVVVPMTTLDPEGVTELSRRLSTGPRRRSAWSNSFYDQSQSFGMDPSFSSKSHLAMGAASPMCSSPYPDARTSPSGIDATTTEHGTFDPFDENNKFDLSYLLHEIYAEMDQRGNERRSMGIAFRDLRVTGYGTGAQLNETFGSLLLAPLRIVSGVRNMMHRPIKTILQDVEGCVKPGEMLLVLGRPGSGCTSLLKALASYRDGFRSVDGTVLYEGLDHRSIDGPLRGDVVYSPEDDVHFPTLTVGQTLRFASATRAPNSKYRITLGETGDRQEYVDGTREVLATVLGLRHTYNTKVGNDLIRGVSGGERKRVSIAEAMAARAKVALYDNSSRGLDSSTALEFVQALRIQTNIADCTTIACIYQAGENITQLFDKVALLNQGHLVYFGPVALAVDYFKSIGFEPLDRQTTADFLVACTDLAGQNVNPDFRGPIPRSPEEQALAFRQSWVGTANHTEVENYIASMMARQTKQNADHYVKLARDERAKYSFHNSRYLLSWPMQVRLAIQRRAQVAMGDLGTHITVIFAALFQALIIGSVFYQMPQNTSGFFSRGGVLFFSLLYNSFTGMSEISLCYEQRPIVIRQKRFAMLHPSADALGNTLLDFPIRAISIFVFDIIVYWLTGLSADAGKFFTYLGMTALVTYCMTSFFRMVAACTKSEPLATTFGGLAVLDVALYTGYMIPRGSMKPWWIWLSYCNPVAFGFEVLLANEYRGKFFECVQMIPPGKSVENQVCPVMSAKPGQPNVSGEDYLSEMYGFSWHNRIRNFVIILAFWIVFILCFLYASDHQVDPAAIGGELQFERSKAKNKNLSAPTNDQEKTLEEGKPLEPQDLSEAPAVGRTGGTIKVSDAIFSWDNITYDVLIKGKPRRLLNHVSGYVAPGKMTALMGESGAGKTTLLNVLAQRTDVGVVGGDFFVNGKPLPRSFQADTGYCQQQDVHLAQHTVREALQFSAMLRQPRETPKEERLEYVETVIRLLEMEQFADAIVGEVGEGLNVEQRKRLTIGVELAAKPSLLLFLDEPTSGLDAQAAWSIVRFLKKLASEGQAILCTIHQPSGELFNQFDRLLLLQKGGKTVYFGDLGPNSMTLVNYFEQRTSMKCGENDNPAEYILDVIGAGATATTDKDWHELFLQSELFTALRRDLDEIYRTRRQIADSSSSKHAREYAQPFPVQLYEVTKRAFISYWRNPLYLYTKMMLNVVSGLVVGSSFWKEGKRNSYIALQNRLFACFLALVASTSLSQHLQPEFIRFRGLFEVREKPSKMYTWPVMVLSALLVEIPWNIVGGTIYWIPWYYLIQFPFESKRSGYSWGLYMLFQLYYCTFAQAMAAISPNAMIASILFSTFFSFVVVFCGVVQPPPQLPYFWRSWMFQLSPFTWIMEGILGNAIGGAQVHCEADEMQVVRLPPGATCQSHMEPFSRPQSSDPRGNGYYVDNNDGTCSFCLYRYGDDYLETVMMDASNKYRDLGIIVAYIAFNTALLFTLFWLFRIFKFGKNRQGKKKIMPAPGPEANMPIPSSTMQVEAPAMAVNVPHVVGAGLTNFMSESSQHPNQHEDLSSRHDAATDISHGTYRQADMATSKTQLMGDESPQMDHGDFLSGEPAMTSHPLESPQRRPHRNLDSLYLDPPMNEAPYVEEDHNDGVETQDDTDQHVPRRHKPSGRRSQYRSAKSRRRRRGSRDHGETLRTPSGYSYYYDATSEPYDDPEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUQ1</accession>
    <name>A8PUQ1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732150.1">
        <property type="nucleotide sequence ID" value="XM_001732098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUQ1"/>
    <dbReference type="GeneID" id="5856456"/>
    <dbReference type="KEGG" id="mgl:MGL_0743"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0743"/>
    <dbReference type="InParanoid" id="A8PUQ1"/>
    <dbReference type="OMA" id="DWIPISR"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010733">
        <property type="entry name" value="DUF1308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07000">
        <property type="entry name" value="DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="854"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="938"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="971"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="743"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1201" mass="132473" checksum="2F00A99A37838186" modified="2008-01-15" version="1">MSSAMTHPLERVLTSMDDVGEAYVAWNAVSPAWRAGPELAWRHGTYVPTEAAIIRTCTPVLYEIHASYAAAPLCGLASFRNVVSAELSFVQATDSPQNNASFLLTFWNEVLYALAYMSPITALQTVHPTQAGANERTCNNAAKQKAAAGATAMVHIAARNGQHWIRLMPIRPDALMREFREYESTVSLSEPPAVDEAMTENSIVRLAHELKHAAAQTSSMKPTLEIILTRITLSDSGSLFDACPAPESVSYWTCPETVRMQRRLQGIADYAASLGVRITFGAHEPMPLHIPIPRPPSTSGDAPPPTQCINLDVSAMVAICSDLSHGFPVHVETHSNRALSAQVSHERSSSLLQVLKDALGHAPTQLVATQEAIDKFASIVDRVASSREYERARWLLGSRRAPCVDEAWARLFPQSVQVIDDLFKASVTWSDTSYTCHLEQALDRLKVRRARPKSLSASPHTVHTLQMGLKKRITTLLAHSHGVQELLEEAGPITGSTLSHAVIWLIQPRSFTSSAPSSVSPRRSSSSSAELITSGKVGPSNSPPLISRPSASTVSPLPFPLTARRPAWNAWLKVWQWMQGPKMPKQHIIKHYPWWPWQHLEAAWLRWTAPLAWKPPASSDLPLWGSEEAPSIELEPTNHMHTIPTPPPAKQGGTPGQRWWAKIECDWQRNWLHWIILCAVCIGWLFCFSVMVHYTWFSARILTNEGWRTPSPFTCTTTLWGRNDECGLDGSSCAPFSDSTMTFQCPSGCAKTTLLNPRTVGDQAYNYVPLVVGGSNSTPYRADSFICAAAQHAGVIGRRGGCGIVRQMGSFTHFDNSSQNGIDSVPFPSVFPSSFLFLHPQDSQHCTDERWRLYIINVVFLAVLTFVVRPMPLFLFWTMSCVGFWHVNLVSELRSMPPPVGAAAGDFGPHLFVCFVIWHCALKHVWGAFQHVPLEFGIGWLGLWWIGVLLDVVFADVPLQRLTVHDISQQPGALSSLVIVVIVVVILAFNQVRVIRSVGLLPKFLTLYIIACVVLGLCAAVPGEVVRIHHYVIGLALLPACGFPTRISMLCCAILFGMYINGVARWGFDGLLQDEGVVRGDAVGDSAIPHFSMNRTFTDQMIRWAPIPTAEQNVWSSFSLLVDDVLRYKGPATSFNLSSILNHDIFENSNLLSQSQIHQSLESGKHFLRLAYSSATDTGDFTKAAIAWFNGTFIKPPAGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUV2</accession>
    <name>A8PUV2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">OPA3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732186.1">
        <property type="nucleotide sequence ID" value="XM_001732134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUV2"/>
    <dbReference type="GeneID" id="5856492"/>
    <dbReference type="KEGG" id="mgl:MGL_0779"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0779"/>
    <dbReference type="InParanoid" id="A8PUV2"/>
    <dbReference type="OMA" id="WFNESES"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27374" checksum="5BBF21EC63EF3F49" modified="2008-01-15" version="1">MATAKIVSLTIRTLAKPIATQIKHQAAHHETFRRICIALAQHMHRTEARLRQNLLPGSENYKIRPLNDAKAISNGANAISEGFLFAVAATIILGETYRSSRSRANHRDHVQEELSQLRAEVDLLNKQLHGDGMPDSTSLMASQSPSLPPSFLSASQTSQLLQAVQLLWTIAKKKGWFDEQENLPAEFKWLLEGDNKQEPEDRANSDELTSTLTNSKFAKARVDAISKEIGENFSQCVSRSESSHMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV74</accession>
    <name>A8PV74_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0819</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731551.1">
        <property type="nucleotide sequence ID" value="XM_001731499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV74"/>
    <dbReference type="GeneID" id="5856348"/>
    <dbReference type="KEGG" id="mgl:MGL_0819"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0819"/>
    <dbReference type="InParanoid" id="A8PV74"/>
    <dbReference type="OMA" id="PMVFESA"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="298" mass="33413" checksum="AE1971C97FD27CA4" modified="2008-01-15" version="1">MWKRLRYRTLIGMSSQMFAQLNGINVISYYAPMVFESAGWVGRDALLMTGINAIVYVFSTVPTWFLVDTWGRRPILLSGAMLCAIMLGACGIILKANQSYTPTLVVVCVILFNAAFGYSWGPIPWAWTPEIMPLAFRAKGSSLAAATNWVFNWIVGQLTPVLQEVIGWWLYILHACFCLCSFALVYFLYPETQGVPLEEMDAIFGDEGAPVPQLDVETDEIRTSHGSDPEVHRLRRSISTHPRFLSEMEHEALLASKRQRSHHRNSLQTSLQQIYSSMTGASTSTDRGEYEALPVDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVF1</accession>
    <name>A8PVF1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0844</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731576.1">
        <property type="nucleotide sequence ID" value="XM_001731524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVF1"/>
    <dbReference type="FunCoup" id="A8PVF1">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="GeneID" id="5855882"/>
    <dbReference type="KEGG" id="mgl:MGL_0844"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0844"/>
    <dbReference type="InParanoid" id="A8PVF1"/>
    <dbReference type="OMA" id="HICRLRY"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="142"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="252"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40164" checksum="1891705EDD4A4C68" modified="2008-01-15" version="1">MPLNDATKDIVAGTMGGVAQVLVGQYVQLRRSSHSQTLRYRQSARPNRRKRHLQRYVESLLYLAGLIQLGMEHSSLTPGVLDCISHILRDEGPMAFYKGTTMPLIGVGACVSIQFGVVQWSKRVFNSMNAAHQPERKSLTPLQLYMSGLFGGVANSFLAGPIEHVRIRLQTQKGHALHGPFDCLKQYVVTKPLYMHFLRYNRMMQHSGIAGVYRGLGPTIVREGHGMGVYFLTYEYIVQKRLEVLGIARDKIPASTSLLAGGLSGLLLWLMIYPIDVVKSYMQTDAIQSQQRRFRTSFDVVRHIQATYGLNGFVRGIVPTLIRVRCMTVVNCSTNSYRLHLRMPQRLPPSKVRGCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVU7</accession>
    <name>A8PVU7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 14">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_0959</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 14"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731691.1">
        <property type="nucleotide sequence ID" value="XM_001731639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVU7"/>
    <dbReference type="FunCoup" id="A8PVU7">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVU7"/>
    <dbReference type="GeneID" id="5855996"/>
    <dbReference type="KEGG" id="mgl:MGL_0959"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0959"/>
    <dbReference type="InParanoid" id="A8PVU7"/>
    <dbReference type="OMA" id="FFGMKKD"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122003" description="Protein disulfide-isomerase" evidence="14">
        <location>
            <begin position="25"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="13"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="355"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="396"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP44477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="501" mass="54774" checksum="D60D3BF70A588481" modified="2008-01-15" version="1">MRGISAWSALVTAVASVAMLGVQAEEAADSKVVSLTQDSFGKFVNDEPLSLVEFFAPWCGHCQALAPQYEVAAKELESEKIKLAKVDCTQEEALCSEQGISSFPTLKVFRNGSASPYTGPRKSEGIVNYMVKQSLPAVSDVTEINLEDFTSKDSFVVVAFAEESDKTTRDELRQFAEDHRDMYVLGVSSSKDLAKAQGVKFPALVAFRKFDDPRAKYQGKGKSLSTDEIKSFVVVESLPLMDEISAENFLNYAVTGTPLAYYFVDPASPKLDDDVKKLTKVAREFRGKVNMVWIDATKFSSHGKALNLKGDSWPAFAIQDLKTGAKFPLNDLGKDVASSVRSFVSKFASGKLSPSLKSAPVPKQTSPVIDVVADEFDKWVFDDSRDVLLELFAPWCGHCKKLAPTYEKLAELYAADAQASKQVRVAKLDGTENDIPPDADIDLAGFPTIVLKPAGKNSREFIVYDGDRTLESLVEFISTNGKHHAKVAISKDSGSAKHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW44</accession>
    <name>A8PW44_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1023</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731755.1">
        <property type="nucleotide sequence ID" value="XM_001731703.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PW44">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW44"/>
    <dbReference type="MEROPS" id="S59.A07"/>
    <dbReference type="GeneID" id="5856060"/>
    <dbReference type="KEGG" id="mgl:MGL_1023"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1023"/>
    <dbReference type="InParanoid" id="A8PW44"/>
    <dbReference type="OMA" id="PMGKGLN"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="12">
        <location>
            <begin position="741"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="185"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="454"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="925"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="477"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1780" mass="186383" checksum="77247A2A42355E16" modified="2008-01-15" version="1">MTPNEPKAHAKTFEVHQSLTSMPGYQNISPEELCLMDYQQGRGKGTAGPNPSSLGASTTAPTTTPAFGFGSQSSMGTNAFGQPQAQTTPAFGQASGTGLFGQQNNNQMGSTSLFGASNTGGSSGLFGANANKPSAFGSSTSTPLFGQNNQASGTGGGLFGNSTMTQPATGGGFMFGANNNQASTQPSTGFSFGTANNQAQNTQPKPLFGGFGSTSTPQQPSQPSTGFSFGSTSTSQPGATNAFGTGGGFSFGSANANNASTQPKPGGGLFGSSATTQPSTTFGSFGAAGNNAATSAQQNKPAFSFGSFGSNPNNTSSTQPSATTGFGAPASTTGGGGLFGAKPPTSTGTGFSFGQPNASAQQPGTTGFGSAATNTGTSGGIGGGLFGAKPAGTLRRNRQQSQPSGGGLFGSSAPKPTFSFGSAGSSGTGLGTGAGAGTGTGAGSGTGFSFGSGSGAGTAGSAPSTTGGGAGGGLFGQSQPAPSSTGPSLFGQSQPAVPSANTGSSLFGGAKPLGASMPTMTGASAQPLQPPSLTTNPYGTDALLANVAGAPAASQSPLPFNVAPKNKPPLVSPFRSSPRNAVRVTRLRGSTPGLDMSRSIREGTPSDRATPVRAGSVGLFRQPSDAVALSPQAFIPRSTSKRLVLDGDTSLSRSPSMLREGTPRASVPPRARFSPAVEKVLSGSGGAFGGDSIAGGAGTGNTSSLSGTGAEADSSLVLPVREPSYTASPAPRGKSARPLQHGDYYTEPSLPALRSMRFDDLSHVEHFVVGRIGFGRLAFLKHVDLTTVPNLSFIAGGVVQLRMKECFVYPQEEDLESDVPLDGLLPNYVPVPKAPLGTGLNVPARVSLEGCWPVDRATREPLRDESHPRVKQHINKLRNKKETDFVSYDALSGTWTFEVQHFSRYGLDESDEDDDDADVDMPAHTRVDMRDADNVDDEDEPPPMKLGEESDDSGSSAMRESELMSGDEDEDEQPMTDYDVWVPTIRDEPVPALARRSMTPAAASRLTPGAPEARKVQVMRASFFGQAPPTSGPVGGVKLSGPSAQLPLRHTSQLMQGRTSANVSNDDVVNADVDEAQEPVAAAAAAVTDAGPADVTDMPPIEEPPVHDRVPVARVESSLSALDTSLCADPGLFLSRSFRIGWACRGAVLAHNGTLHGLACPGWTQVYLDRMRVYKNEAEQAASLSTARKLLELQLASTHIEPSKEGGSIPRVSFQPNTTCASIAKHYAPDDKQYAAQLWHLASVLFDPVDLKLSNDASDAWHEHVLQRRRKTAFSSWLERVVSAPVQADVRAHIAASRQTDLVFALLTGHQVEHAAEAALEAGHVRLATLVAQAGGSLDVRADIQEQLDTWHAEGVDADIDHAMLRVYALLAGQVVSAQVSGARARDARTIAMARGLDWRRALGLHVWYGTPWESPLEASVRSYEAAVHAPSETVPPLPTYQAEAQLGALKQRELIQQAGAPRDALFELLKLHVDATYPLEHALDARNFGKSALDHTLPWHVCMYLSRALRVRSCMDPHVEDRLTSLYAAQLEETGEWHWAVFVLLHLMHDQVRAQAVQALLARHVDVLDAHSAFLTTTLHVDETWLWQARALAAHARSDYFAEYECRRHARDLSGAHAVAVRHLAAESFLRGDTQLLVDLFRPIADEAEASSAVPIKGWNEGGRVLLDYATLPQILPPLLAKAHTGSLEASERHALQQATVRTHELMDRVPLLYADTTDLMSTVARSEMLAVLQNFSRLLASEAGAPEPVRHWTAANPPEVEQLQAAARDFTSSMLACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWG2</accession>
    <name>A8PWG2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731821.1">
        <property type="nucleotide sequence ID" value="XM_001731769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWG2"/>
    <dbReference type="STRING" id="425265.A8PWG2"/>
    <dbReference type="GeneID" id="5856126"/>
    <dbReference type="KEGG" id="mgl:MGL_1089"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1089"/>
    <dbReference type="InParanoid" id="A8PWG2"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48836" checksum="28B2805F5701CD20" modified="2008-01-15" version="1">MTRGRHVHWAPLQTADPRTTSTATDAATTSSLSPLSSHQILACVLAQWRATSQQLGSTQESISRMDAFFSSLPTDFDTMPLTWMLDGRTHLLDALPPSAVHKFASVRTRYENDWSRVRSLDSTTLESLWASVGLPGTRAGALNERHFAWGWLCTNSRCVYMDLHYVKHEDNFTLAPLLDMANHTALRQKECTVRYSAVDGMELCAPPESSLQAGEAVCITYGPHDNATLLVEYGFVLPRNVNANRLGLSDQVNAASSWHGNPHASVWLDEAVDRLMESQGAAGEWKRSLLQKEGYWGDYTLQAKPEPAHPSHRLYTALRLLSMEVQMGANDKTDTTSTSASTKKRCMERVYLPEDAERVWRLVTYGVRDQLPAANEQVVRQFLVTLCHDTDHELTARLTRLDGMDDASSCMVRTLLVEERMIARIVRAGVERGDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWH6</accession>
    <name>A8PWH6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731835.1">
        <property type="nucleotide sequence ID" value="XM_001731783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWH6"/>
    <dbReference type="FunCoup" id="A8PWH6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="ESTHER" id="malgo-a8pwh6">
        <property type="family name" value="Duf_726"/>
    </dbReference>
    <dbReference type="GeneID" id="5856140"/>
    <dbReference type="KEGG" id="mgl:MGL_1103"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1103"/>
    <dbReference type="InParanoid" id="A8PWH6"/>
    <dbReference type="OMA" id="AIQNMEL"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="770"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="945"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="814"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="846"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="976"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1012" mass="109888" checksum="CF0F075AF0A51758" modified="2008-01-15" version="1">MPIGTWNDSDDEWQDMPIEHIGAPTIPNVLDENDSDGDMSPRTRRATREAKLMHNRREHLRGRGTSAQGGTSNTAGQHLEIRDARGYDWRTRPGSHIGDSQPEPDGTGYTRLRLDDKEENAELQAATDYLFQEDLNRVDDADDPSAAPISQLAMTKRLLSEAQKIAYVGLCSTLSHHMVQDLSTYTNKETHPAIQSAKEWVLRVMIRLYQHLDIEPTEQSMIESLPLHGILSSDLAPSLVATQTIPNPAYNPQSAKQVPVSRPPSPPAPSWSQQASKPQHSSHSSEQDISQPASDSPPKTPPQRATPSEAEQMSAADPSSPSPNVLTDPNSAMQLAEHAANGPSVPTRVPEASLKAPPPSNQPTTSMPTLDGVSTEINEASKTITLDLRWTVLCDLFPWFLNLAEYRCLNPRSAPRREPATGAAVGISGTSAFLGGVGGATIITTTGTISGATMGGRGMSRRIRSVQTFEFRPLHYHKRVNCIITVPGFLKGPEDDPTLPYSVIDPIMGDVFSIMWEPQMMQEMGNAMSILWNETLVQGVQQVLAATVAGAMFSALAWPLWLTKLNYLIDNPWSNATERARTAGLVLADVLINRQMGVRPITLVGYSLGARMIFFALLELARRKAFGIVQNVYLMGAPVTSREYEWRTARSVVSGRFVNAYARSDWLLAYLHRATAGGVRSIAGLHPVDFDCGIDNIDVTNIVPGHLAYRALTPLVLGELGFQTTADYFDEPESLDHVPERSFETGNKPAEPATAAQKLKNLFWGNKAQSTSSAYAPPTPMGKDNHQNKPKNSVIYDAFDECDTPKPDARQVPTTDTNNTDDASAATVNVDKPEPVANAKGDARSNAISQQMHPSAETNESATSPSSHDNVEPLTELSKEGTSIVTTEPPQPPLQQEDGLQPRNITTKSYYIPADTDASMPSFATYGLAPDEAAKLAAQFNSMSTSTSMPVDSFEPADSGNPVENEWGTQTQKDGVTTTSSAAATAVDTTRPSSTAEEPSDLPDWASKNPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWI6</accession>
    <name>A8PWI6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731845.1">
        <property type="nucleotide sequence ID" value="XM_001731793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWI6"/>
    <dbReference type="STRING" id="425265.A8PWI6"/>
    <dbReference type="GeneID" id="5856150"/>
    <dbReference type="KEGG" id="mgl:MGL_1113"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1113"/>
    <dbReference type="InParanoid" id="A8PWI6"/>
    <dbReference type="OMA" id="GIKSTMY"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="229" mass="27023" checksum="663A2E25D8166DD5" modified="2008-01-15" version="1">MPSLQLRLYQFDRLLEDMLPVLHAHFLRRGIKSTMYASQWFMTLFSYRFPLDVVYRILDAVFSEGIDAIFRFAIALLRKNEDTLLTLDFEHCLDFVKLYLTDVYCGTSKDSALTARQISELVRDAFQIKISQFTLDSYANEFYEQAKAASERQLESDALRLMNRNLRLRVQSLEEQLNHLSNEHVDLVKRVVTEKLSQEEMAEELVRYKVMYAEAVLQNDKTRYRSDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWW1</accession>
    <name>A8PWW1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731969.1">
        <property type="nucleotide sequence ID" value="XM_001731917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWW1"/>
    <dbReference type="STRING" id="425265.A8PWW1"/>
    <dbReference type="GeneID" id="5856274"/>
    <dbReference type="KEGG" id="mgl:MGL_1237"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1237"/>
    <dbReference type="InParanoid" id="A8PWW1"/>
    <dbReference type="OMA" id="LCQSFMD"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727988" evidence="2">
        <location>
            <begin position="32"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="447" mass="47891" checksum="D392DCFAE41A78E9" modified="2008-01-15" version="1">MTQPTSSAKDTLPSTLLRLCVLCASSLEAMSTSPTETVDKTAASQDGRALSERISSDTLALVQKVRKEVTALSLAMRPSSSFEPQDHSEPLDGVDDKSIEAASHLLQSLATEAVPKLVFLANMALTRVRVYSIADSAEHDPLVEQARESGAHIVLGEGAKGPLADKACLGALFVKDLRLLITDIVAGIGELCQSFMDTRTRTVLARAQQKREGTGKPSNPLPPPSRAASLALTKKLWTLCDAAEGDKTHTPAYVARLPRNNYEALCKSIRRNELLMRDSQSELQDALDDAQSHAIGAASDSATEQASDSAPKQEPASSDETEELDDVEDMWEQNVLASEEGRVTARAVLDLVTSGIKLVQSLSKSLPKDASEHRLDDIANCMDALAAAQDELTCAALFEDDSSETNVNASTIAYVDACKQLCERVDGRTIPDIESLASKLKSSQPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWX7</accession>
    <name>A8PWX7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731985.1">
        <property type="nucleotide sequence ID" value="XM_001731933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWX7"/>
    <dbReference type="FunCoup" id="A8PWX7">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWX7"/>
    <dbReference type="GeneID" id="5856290"/>
    <dbReference type="KEGG" id="mgl:MGL_1253"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1253"/>
    <dbReference type="InParanoid" id="A8PWX7"/>
    <dbReference type="OMA" id="HLIMIAI"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="3"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="506" mass="55688" checksum="14AA23BB4025C5A3" modified="2008-01-15" version="1">MRHLCFLTLGSGIGTGLFIGSGNILSSGGPGSLMIGFILLGLMVITVIFAVGELVATFPSAGSYSHMLSRFVHPSFGFAVGVDYLMTWLIIFPTELTAACMIIRYWDKDEVVPKGIWVALIVAGVLTVNMFGARVFGEVEMLTTTIKMLSCVGFIICCVVIVCGGAPNHHYIGAGTWHNPGAFNNGFKGFSNAFAFAALAYGGTEVIGVTVGEAGNPRKQLPKASKFVVYRVIIFFILSLFMVTLLVPYDEPNLVGSSSSPRATPFVLALKRGKIHALPAIFNAVILLSVVSVSNTAVYTGSRLLYSMAESGFLPKIFMYSDRKGRPMAGFALLFLFGLLGFLVYSSSEDEIFSWLGSISGMSVILLWMCISLAHVRFRYAWKKAGYRVSDLPWTSPLGEWGSWFALILNILVLMATFYISAFPIGEAEMDGYERGKAFFQSYLSVVIIIVAFLAHKLFTGARFVRIHEIDLHTGRRDPHMDSETEPEVRADYLKPRWRRILEVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX03</accession>
    <name>A8PX03_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1279</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732011.1">
        <property type="nucleotide sequence ID" value="XM_001731959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX03"/>
    <dbReference type="FunCoup" id="A8PX03">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX03"/>
    <dbReference type="GeneID" id="5856316"/>
    <dbReference type="KEGG" id="mgl:MGL_1279"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1279"/>
    <dbReference type="InParanoid" id="A8PX03"/>
    <dbReference type="OMA" id="INLICRI"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="375"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="494" mass="55572" checksum="67CE8F5166196C24" modified="2008-01-15" version="1">MNAQPLGSTRRWGSSSVSSGGGGAGGYEREAPKRSFNHDMTREPAHEGARKRRSRWGNETDRKDVSSAAIPGNVSGQELDRYAVQVRMDEINRKLRTGDVIPPERERSPSPPPTYDSHGFRNNTREIRYRRKLEEERTRLVERQMRLDPSYRPPLDFHASRKAGRPTEKVYLPVREFPEINFFGLLVGPRGNTLKKMEGQSGAKIHIRGRGSVKHGKGSTDGEEEDMHCIVTADNDRSIKHCIKLINEVVATAASTPETQNDHKRSQLRELAVLNGTLRDDENQVCQNCGEKGHRKFECPHDRNWTTYIVCHKCGQSGHVARDCFSAPQNTGEMMDPATSHVDTEYATLMAELGEQPGGYSSGYLGVSGYAGPPRNERGEKIPPWRDPEVWNAPGPGRSNRDSLPDSSYAEGGWNSLGSNERAWATETQPVEGQRDYTAEWAAYYAAQAAQQQQSGNAEQDGAPVRDYSKEWEEYYRQQALAQQQQHQSHHEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX17</accession>
    <name>A8PX17_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732025.1">
        <property type="nucleotide sequence ID" value="XM_001731973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX17"/>
    <dbReference type="FunCoup" id="A8PX17">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX17"/>
    <dbReference type="GeneID" id="5856330"/>
    <dbReference type="KEGG" id="mgl:MGL_1293"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1293"/>
    <dbReference type="InParanoid" id="A8PX17"/>
    <dbReference type="OMA" id="PQLCSNI"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44554" checksum="13D9B073DC95C5AB" modified="2008-01-15" version="1">MHVCEKVSLFPHNNSQAKRFKTLLQDYLLYVQQYPWPANAYQFTGTYDAWVKVYSAMIACFTLPDTVWLVRALKYVAMQLVLLAIRIDNENTQKTFSKTIDAAGRLSKGAGLAANDRSPSPGVQTKRAAVLKLANLSFRAYFQLKNTRLCETVLGSVHNALLMNRRNDESTMSGEELYPVSERVTYHFYVGQIRLFQHRIQAASQHLRWAFDNCTNAHAHNKRKILISLIAAHLILGRYPKLPLLRDYDLVQQYAELARQHRLGHAARVMAELERNRDWLRARGLYMILREKLALGLWRNLFQRCMRLIPDTSGTSNAPPTLPLRKLVRPARLAWNDNTLSLEDLECMAANLVDQGLMKAYILHSKEMIVLQRGPHRGFPPVKDVYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX94</accession>
    <name>A8PX94_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731187.1">
        <property type="nucleotide sequence ID" value="XM_001731135.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX94"/>
    <dbReference type="GeneID" id="5855494"/>
    <dbReference type="KEGG" id="mgl:MGL_1370"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1370"/>
    <dbReference type="InParanoid" id="A8PX94"/>
    <dbReference type="OMA" id="CELPWES"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1701"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="758"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1018"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="783"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1030"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1069"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1886" mass="204168" checksum="970A20A064E2E80E" modified="2008-01-15" version="1">MPPPRIAQRSGSVPMRHGKLRALDEVLTSLSNAEAIRRADVAALITHMNASSLAHALSLYTSRSTAPTNAGVGWHVHHEDPIDAASVRTAKLVVNAVLSALQVKRSATTTTKFSPQDVLPWLDAFRISMCVLVSSNMDVLTLAPVALSVIRRLADVHMDDYALTELVALRTCIDPSSFTLSATRSVHEPGSAAERLRACMSYACEAPSSAYTTLVLDAYACALQVAPAVASFLHTLVDVWPSLAEWNEYGRAQGLDAACDRTAYMAERATSKMSQTLQRKPDKHQDDPSLTVEALTLRMAALELIMPAASLDPDAVWDRAGRLGALHGLEASYNALVQVYESAQAHQMACGTSFERVITWWTRAAHALGRCDLAPPASSSIPQISGGVSDAETWSACLAALASPADGSTSIPAELMTLPSTPVPPSFVSSLSSQLRTALRNEGPSPTFLIRALHIVRHVPATEGLAMEAVHAACLLLKLVFSEHEPASFDACLQGSESAHAVATPPHQHTLAAHLFHYGSRLYAVKQYAHASRFVQLACTCTEASLPADPDGSWRIALVRQYHVLAGALQHMSQYRPAYTAYMAGVRHAFQAQQNSAEATDLFVRVLRGAHHVSVFALLDPHVLVADVTAIPTATAELRGRAFVSLLDELMPMLQREEAPYAFDTLCTAALDTYDVGTHPVERLRVLLRRSELRVLRQEHVDWDDVRSTVDRVADKAPTPVLLELTLTFYLLATLDCVQMHSYSDALAHVQQARAWHDAHTPAANKSNGQSTRAAVPRRAGSRRNANAAGAAAIAANAAATKTPSRMPSRPPSHPPSRTPSRSLASLPSTPQRREVLDPNDTSHEWTSSMSSLFLLVCDALVYAGLPTAALDILRLAQSEYDAPIIHVRHAEVCIMLGAPDAAWEALCPFEQTSARAMLVHAQIKAILGHVSDAQSLYDAAISEVDVPRCGASAAWERGWDKASLWELQSCAAETCAVVYTASGDASEALHALLHALRIRLRTAMLLAQAAPAAGNVDIQRGEDDDDVFSSSPTRTRSPTRPDHRSARPSSRRVAISSGMPSADKAGVARAASASTTKAPSTRFSGRGMSSLQWRTSCGILSLYRSVSQMYARRGAVRDADAFARECVDFGDTVSVPWMRASAHAWLAEWTCSCGDTASAAQLAAQAYESNTQVCPSLARVHAAYVLDVVADDGVFERSKQCLHEVEEAAKMRVWHDMHNRITCAQAVRLVDTRSGAARDLVSSLDGCAAHLIRARTYLAEARAAIQSDAVFGMLPDMARSVPSVMPSSRRVSPAIRSAYELLEQARAAAEHVLTNAAVLDVCDVRMALVCAREAVLTSASLGRSSVADEASSGTASALSPAPSMSSAACVVAAMTNAVSSISVRRACADARVRRAMRPKAEWLHRLSASSVVKPWREYDVQAMPTWSDAGAAAAVISLSSDARELIVARYGDAYDPCVFVLPLHRQSYRDAEDDDDVLHVETVMTELRQIIHSSNVGVQGAKDVKALEARKVWWTHRRALDAQLGSLLQLVQDAWFSGLHGLLAPWPSPSAMYCLRDKVESVLACACGSPTRVRLTRALPDASLACLAAMQTYRDEDLEDWLHYALDAYQLGGVPVAQDEVDLDELCVDLRSALDEFHVKYAGFDAQQHHMYLVLDRHLCELPWESLPVLRSQSVTRLTSLDQLPHCVQKNPSEPIPLRTSNTAYLLNPSGDLTRSEERFAPCLQAHSTWHGTIGRAPVLDEVAQALASHDTFLYFGHSGAEMYVHPARLRELSRCAATMLWGCSSGALQVQGVHDPMGTPYHYAVAQCPALLAALWDTTDRELDLVCEAVLQCVGLFADREATSSSEPKRLSLSQALVAARERCKLPYLTGAACVVYGAPVIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXC2</accession>
    <name>A8PXC2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair and recombination protein RAD54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1398</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731215.1">
        <property type="nucleotide sequence ID" value="XM_001731163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXC2"/>
    <dbReference type="FunCoup" id="A8PXC2">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXC2"/>
    <dbReference type="GeneID" id="5855522"/>
    <dbReference type="KEGG" id="mgl:MGL_1398"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1398"/>
    <dbReference type="InParanoid" id="A8PXC2"/>
    <dbReference type="OMA" id="KMICVEV"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="256"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="585"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="80467" checksum="1BF388E646F31B31" modified="2008-01-15" version="1">MRRSAVVAALKELQDNSSDHTRESPRQLATGGGYGILQEQKPFKSPLLKKRGPDASLRKRARVNYSELSGDSVDQSGIYIDEIEGPRKKKSLEGVYKGIDASGVSFNADRRKWQVFHADPRAIKRKFSIPSIRNERGEVIESQLSHAALGVRRPVEVPPRPLHDPMSEHSIVLFDPTIDDKDIESEREKLRLAFEEQQKKEEKRGPHKNLATILGINKPHMPIRDKVPVVIDPRLGKILRPHQIEGVKFLFRCTTGMVSENAHGCIMADEMGLGKTLQCITLLWTLLKQSPNAGKSTIQKAIVVCPSSLVRNWANELVKWLGASAPGSLALDGRLSREQMFESVQRWADCSGRAIVHPVMIVSYETLRNLQELLGNTEIGLLLCDEGHRLKNADSMTFQSLAMLKVKRRVILSGTPIQNDLSEYFALINFAIPDMLGNRNEFRKHFELDILRGRDAGATEKEKEVGREKLQQLSGMVSPFIIRRTNDILSKYLPVKYEHVVFCRLSPFQVDLYNLFLRSPVIARLLRGIGSQPLKAIGILKKLCNHPDLLNLPADLEGSEELYPEGYRPGDRRNVAVGLSGKLAVLERFLTSMRAKTDDKIVLISNYTQTLDLFERLCRSRRWGFFRLDGTMNINKRQNLVDRFNNPEGSEFIFLLSSKAGGCGLNLIGANRLVLFDPDWNPASDQQALARVWRDGQKKSCTYALVFFFANKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXD0</accession>
    <name>A8PXD0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731223.1">
        <property type="nucleotide sequence ID" value="XM_001731171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXD0"/>
    <dbReference type="FunCoup" id="A8PXD0">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXD0"/>
    <dbReference type="GeneID" id="5855530"/>
    <dbReference type="KEGG" id="mgl:MGL_1406"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1406"/>
    <dbReference type="InParanoid" id="A8PXD0"/>
    <dbReference type="OMA" id="YKAPNDG"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000052">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="38"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="323" mass="35569" checksum="FFEDD48CDDD292AD" modified="2008-01-15" version="1">MAQDRIQASNVTPGNVSTQRVKLSSGYEIPQVALGVYKAPNDGTTEQAVKWAFDCGYRHIDSAARYRNEEAVGRALKEWTAANNVPREEIFITTKLWDDDHKNAQEAIEESLRKLQLSYIDLHLIHSPEPGEQSFIDAWKQMEAAVDAGKIRSIGVSNFDVDHLDALLKVARIKPVVNQIESHPFFAHEKLREETLKRGIHIEAYSPMAQGAALDREEIKAIATKHGKTPAQVLLRWGIQVGNIVLPKSLTKHRIEANAQLFDFELDSNDMDVLNNIDEGMKMGKLGPPGTSAPASPGATRPGSRRTSGSSGLAGNQLQMSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXN4</accession>
    <name>A8PXN4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731305.1">
        <property type="nucleotide sequence ID" value="XM_001731253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXN4"/>
    <dbReference type="FunCoup" id="A8PXN4">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="GeneID" id="5855612"/>
    <dbReference type="KEGG" id="mgl:MGL_1488"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1488"/>
    <dbReference type="InParanoid" id="A8PXN4"/>
    <dbReference type="OMA" id="NIMFATR"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35450" checksum="F11C1C186305EE84" modified="2008-01-15" version="1">MEHWKNFTASVSPIGQRLSERFGALNQQAREHFGHADDLTELPEEYKQLEQRVDALKNAHQSMMRSIKTYENEMYDYPHALQESVSHGAQNLGHTLSMWASQATKNTNLPQVHATSAPESHPRTLSHAIARSATAAAIDLSKCPPKVPAYTGGELVPTTESKLGELLRKFAVAEDAVGHARLTQDHSIVHSFIVVWNAFGAQIQLAVKARQQVRDARLHLDGWRGHLKSAEQSNTSSSKLDSYRHEVEQAEDKLVSATEEAISLMKTVLDNPEPVKSLASLVQAQLEYHRSAAGTLEQLSQEMTAVVTSVESEFRESRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXY4</accession>
    <name>A8PXY4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731369.1">
        <property type="nucleotide sequence ID" value="XM_001731317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXY4"/>
    <dbReference type="STRING" id="425265.A8PXY4"/>
    <dbReference type="GeneID" id="5855676"/>
    <dbReference type="KEGG" id="mgl:MGL_1552"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1552"/>
    <dbReference type="InParanoid" id="A8PXY4"/>
    <dbReference type="OMA" id="APVACAW"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="76"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="5">
        <location>
            <begin position="241"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44015" checksum="951179C536717EE9" modified="2008-01-15" version="1">MRVRAFDDADDEDAEASAPRMAPARKRKPPRQGAMSSFLRELQEAQAKRAESLSIPKAKETYREHVSGSEVQLDSTNICVQPLPASAMSEHRLGTFFAQWGDVACVSLSKKEPSVTASAYAHVAYTSRRDAELALQETNGLVWNDVTLSSSWAPPISLPDGEPAYSARRSRKRRAREQGHYAHAQGGRECSPVPVRHRHTHRSTSPVHISAEFQDAGYASMYSTDSEEVSESDLHRGNGELPMLAARRLQAMLKGLTPRRERIARCMKLALDHADAAPSVADMIARSLLVPTTPLPRKLARLYAMSDILYNTAAPVACAWKYREAFQPWLEAIFLHWGATIRACPLCQTTEETKQQVLAVLTCWDTWLIWPPTLLKHLRDAVEGPETLDHNKTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYC0</accession>
    <name>A8PYC0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731449.1">
        <property type="nucleotide sequence ID" value="XM_001731397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYC0"/>
    <dbReference type="STRING" id="425265.A8PYC0"/>
    <dbReference type="GeneID" id="5855756"/>
    <dbReference type="KEGG" id="mgl:MGL_1632"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1632"/>
    <dbReference type="InParanoid" id="A8PYC0"/>
    <dbReference type="OrthoDB" id="3333653at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20907" checksum="D11AE9845D94B50F" modified="2008-01-15" version="1">MMRGTKYGLLLQSPDTKAPKFDLVYGGGSHFILRACAEASPLYAVGDNRFGQLGSVRIRNDNTTLHCVSYFSKDQGFPAGVQHVACGDRHTIALSTEGDAYVWGWYAPWGYSPPAPVDLGDNQHDYANVKAIACAADASVFVLADESVWINGEKGIGLSSTTKTRRVKMDTKMNNVLNIGASQWTFFMLVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYD7</accession>
    <name>A8PYD7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="5">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731459.1">
        <property type="nucleotide sequence ID" value="XM_001731407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYD7"/>
    <dbReference type="STRING" id="425265.A8PYD7"/>
    <dbReference type="GeneID" id="5855766"/>
    <dbReference type="KEGG" id="mgl:MGL_1642"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1642"/>
    <dbReference type="InParanoid" id="A8PYD7"/>
    <dbReference type="OMA" id="PAMHIAF"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="263" mass="28587" checksum="48900B8019344508" modified="2008-01-15" version="1">MIDDIVSIGALAKRHKIGCHVDCCLGSFLMPFLEPAGFVSEPFDFRVDGVTSISCDTHKYGFAPKGSSIVMYHTEALRRYQYYVSTDWVGGVYASPTLAGSRAGALIAGAWAAMTSLGRDGYIQSCREIVGAAKEIEKRVRAEIPELVILGKPLVSVLAFASAGNVNIYDVGDQMSRRGWHLNALSGDMPAFHIACTRLTVPVVDRFVHDLKESVAASRSRPSKSGAMATVYGLHTTTPVAPMLLKEMAARYIDTMYKLDKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYF0</accession>
    <name>A8PYF0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731466.1">
        <property type="nucleotide sequence ID" value="XM_001731414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYF0"/>
    <dbReference type="STRING" id="425265.A8PYF0"/>
    <dbReference type="GeneID" id="5855773"/>
    <dbReference type="KEGG" id="mgl:MGL_1649"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1649"/>
    <dbReference type="InParanoid" id="A8PYF0"/>
    <dbReference type="OMA" id="DRHCNAI"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 3" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="252" mass="27647" checksum="9448A1BA09898D07" modified="2008-01-15" version="1">MALHAYSLWIFDRHCDVIYHQDWSHLHQRLNATASSASSLTSSLSSTLQLVGGGSSEADKSGPHTAPKRARGETMDGVTRSVNAANDDAAIDPRLLPFDEEAKLIYGLVYSLRNLARKLGGSQETFHNISTTTYSLTHMQTPSMYTFVLITDPPPRVSDKSAFFGTPGTTTIPGTNGMNLRGVLRELWRGPWVQFGAHHPLVGATERDAFGVQTPSSSSTSSHIQRKRGIDNDALRKSIERLLAQYKLLPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYK2</accession>
    <name>A8PYK2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ERCC1-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1678</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731495.1">
        <property type="nucleotide sequence ID" value="XM_001731443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYK2"/>
    <dbReference type="FunCoup" id="A8PYK2">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYK2"/>
    <dbReference type="GeneID" id="5855802"/>
    <dbReference type="KEGG" id="mgl:MGL_1678"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1678"/>
    <dbReference type="InParanoid" id="A8PYK2"/>
    <dbReference type="OMA" id="PHCVLVH"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="284" mass="32276" checksum="3EE8B4912D6C8BE7" modified="2008-01-15" version="1">MTAHRPTDERPVRPQPHRLIRGAQSSSSILVNSCQRGNPVLQHIKGVAWEYADIVPDYQVGISNGVLFLSLRYHRLHPEYIHMRIQRLAHMYTLRILLVVCDVNDHQPAIRELTKVALVNQIVMIVAWSAEEAAHYLEIYKAFEQKPPDMIRAKVGDDSLSVLQSVLTNVRGINKTDVLTLSTRYHTFRDIVHESSENLFMLPGMGDTKARNLTRAFRQPFRTDAPRSYSDTDAPVPLSEHSKAFETETPSNAARPSGLDSLPENFESLPEEEQLRIAMQLSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYN7</accession>
    <name>A8PYN7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731513.1">
        <property type="nucleotide sequence ID" value="XM_001731461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYN7"/>
    <dbReference type="STRING" id="425265.A8PYN7"/>
    <dbReference type="GeneID" id="5855820"/>
    <dbReference type="KEGG" id="mgl:MGL_1696"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1696"/>
    <dbReference type="InParanoid" id="A8PYN7"/>
    <dbReference type="OMA" id="CIPKANH"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="94749" checksum="CD3125D6CD22776B" modified="2008-01-15" version="1">MLCIPKANHKRLVDDCYPTSKALVNAAPEYRPNANELGRLVYYAQCKPAKLSKVGRLLMTRASSESRAFMTANTEKNKALVMITLGVLRDLVSSCQEGHAYLAPAVRSMLTDAVNVAAPTGSAMTSWDMDICARASSIFAMYVQSIPAGEVDTDDAVSSAVFQGLSDLQRLGKGHASDQSRMIWIAGINGLIRSPVLMTPLFPRFLPLILPIVLDTLSPAHIPLSQTATLSQEIDNDPAQSLNSMSHSSAEQSTRAALKMLWSILHRCDATQLRALLTQTLAYLDGECHRPSTWEDNEWPLWILAVLIQWSLPSSRYVVPHCLVNALTTPKKMSNIRETRLLQALHVILESKTDIVGLNMTELLDGHVFFLLSRVQNDPYDATTVQATIDAICHLANYTVYSDQLDDFVQQIAPHILNVLYDTQLADESKKFSICALLSCLEALFRSHPNAHVPLRTWASTEAILASRNSTVRVAYLHTLLVHLRIEQALLEQGHTTYEPVNECIGFLHALAARMYTLATLGLVDDAATPTSDVTPSFSATPADYAMMHDMLDTLLIVAPAASLLAFVPPWLSMAQVSNSPGALEPVVVNQTLAIRWLVGATLAQISLVWQIQPILDYVRVYQLPSIGRAVPEAPTLPDKYHPLNDMPPFKHAAFAAASENEWDLPLIIEHLSLQVELQTSTHADAPSLRAWFSRPWSVPATAADARTAAQPTITRSSTFTKAFRSASPLTRENSMDVRKLRMALMNHSSNAGTIPASLMNEKSSPIPSTPMHRRHHSRSIHTHEAQQSVSDVLDRYTSKASRRAPLSPNVAAGSGSPREKVPLQTAAATKAAPAHGLAPTIAEREAAQWLAAQRNTGQTLVVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ78</accession>
    <name>A8PZ78_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1895</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730896.1">
        <property type="nucleotide sequence ID" value="XM_001730844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ78"/>
    <dbReference type="STRING" id="425265.A8PZ78"/>
    <dbReference type="GeneID" id="5855203"/>
    <dbReference type="KEGG" id="mgl:MGL_1895"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1895"/>
    <dbReference type="InParanoid" id="A8PZ78"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="197" mass="22919" checksum="8193A3F8E22992C7" modified="2008-01-15" version="1">MSSSSADNVDGRTKSKELEHTDLVQPASHILALPVDYVPSHATTSLFSSLRQRRPPSDDDWPHNEFEFEPFVKRDLQIKLETNDQLCPRFKRGRCELGSQCTLRHCITPSPAIPTSQSRDVSRRTVCKHWLRGLCKKGDLCDYLHEYDLRRMPECRFYATFGFCNSSDECLYIHIDPSVKRRRCERYERGFCELGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0J5</accession>
    <name>A8Q0J5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731043.1">
        <property type="nucleotide sequence ID" value="XM_001730991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0J5"/>
    <dbReference type="FunCoup" id="A8Q0J5">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0J5"/>
    <dbReference type="GeneID" id="5855350"/>
    <dbReference type="KEGG" id="mgl:MGL_2042"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2042"/>
    <dbReference type="InParanoid" id="A8Q0J5"/>
    <dbReference type="OMA" id="TANTESW"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="9">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="8">
        <location>
            <begin position="168"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="244" mass="27498" checksum="D251CF22B8C887B4" modified="2008-01-15" version="1">MKPCIYNSVKAPTDGLLDSKYLLNLSDMGAEMTRQMRLKADAFDVDEFMHLVSRLLGAGIVPLQGSSLDAETSMETANTESWDWARLGRLAVRHSRRVPIADHLLGPLQVTPRHRKVTRTSRLDTDAVQTAPSQLNLSDMAQSENETSKLVLDIERRLEACSDGEKGVNLFQFALNPHSFGESVENLFYISFLIRDGKAAIVENDEGDPMLSMYRDDMKEKMSIMLTMLQCCQRSPQMRIVKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0N3</accession>
    <name>A8Q0N3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731059.1">
        <property type="nucleotide sequence ID" value="XM_001731007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0N3"/>
    <dbReference type="STRING" id="425265.A8Q0N3"/>
    <dbReference type="GeneID" id="5855366"/>
    <dbReference type="KEGG" id="mgl:MGL_2058"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2058"/>
    <dbReference type="InParanoid" id="A8Q0N3"/>
    <dbReference type="OMA" id="EPIGRRH"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05519">
        <property type="entry name" value="Bromo_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="362"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="60236" checksum="76AA03E8624788BE" modified="2008-01-15" version="1">MDIMEDFLRFRGIKYLRLDGSTKPDDRSVLLRQFNDPNSEYDVFIRSTRAGGLGLNLQSADTVIIYDSDWNPHQDLQAQDRAHRIGQKVEVRILRLVTEKSVEKTILARAQSKLEINGKVIQAGKFDNQATADERELLLRAMLEADNEEEEEEQGELNDDELNELLARSDEEVAKFQQVDRERIADEETEWRALGHTGPMPDRLIQEHELPAIYQRDFDTDVIDGIEEEQPLTRRRNVVRYDDGLTEEQFLRALEDEEDLNEVVERKRERAEKRRLKHSGQDPEAKLSKDARSESPADAATNDKKRKVLEDGEQAVMAEAMPDSADAAAISKRRKISPDFERLKAAMLKCYHAVEQCEEPDTGRLRSTLFMEIPKKNEYPDYHVLIARPVCLKQIKRRIETRVYKTFEACRDDFLLMFHNARTYNQEGSIVWLDSLEMEHVFNDVYAQTQAELASSSTSTSTSETTGMPALSDSPSTDTPVSSIEDSSHAQSTADANEEMPSSESSQRRKSGMKIKLSMSGRRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0Q6</accession>
    <name>A8Q0Q6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731068.1">
        <property type="nucleotide sequence ID" value="XM_001731016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0Q6"/>
    <dbReference type="FunCoup" id="A8Q0Q6">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0Q6"/>
    <dbReference type="GeneID" id="5855375"/>
    <dbReference type="KEGG" id="mgl:MGL_2067"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2067"/>
    <dbReference type="InParanoid" id="A8Q0Q6"/>
    <dbReference type="OMA" id="HCWRCKT"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="8">
        <location>
            <begin position="94"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="9">
        <location>
            <begin position="802"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1057" mass="118758" checksum="BC77CE3A9A3B147F" modified="2008-01-15" version="1">MRLNKSGRSLSTSWLWRTQCSPARKQLAHLHAGCIVCAKKRRGGNKNKDANPYQDTLRLPQTSFGLRAFAKDREPLFRLATTTNLYRWQREHLRPQADERDFVLHDGPPYANGHLHMAGHALNKIIKDIILRFQVLQGRRVHYMPGWDCHGLPIEIKAVAEQGGTPASELKATDIRNAARRVALREIDQQRVEFQQFGIMTDWSDENTYRTLHFSYELEQLRLFAQCVGRGLIYEQFRPVYWSPSTHTALAEAEIEYDDKHVSRSTYLRFRLHPSTALAPVLSGVQEPMYLAVWTTTPWSLLGNMALAVNANAMYSIVRRKESGELLVVASDLVASLATVPLSGGAIGEQRHGSAGTLGPFEHVTVVRGSQLVGSMYECAWMMPGEQRFVMDAPFVTTDAGTGIVHMAPAHGQEDYELWRDAGRLRTHGIMSPVDDYGRFVVNNAWGLSDIIRTDLKQLHGLDALSCGTQRILEFLSRHHVLLSEQPYTHSYPIDWRTKQPILTRATAQWFADLRQSQAAALAALQSVHFTPASGRQRLTSLVSRRSEWCISRQRAWGVPIPVVYDADTHEPLINATNVEHILRIMAEHGTTDVWWTLDADTFVAPAFREPGKSFYIKGDTLDVWFDSGCSWAILQRALQEPLCASHACADVYVEGSDQHRGWFQSSLLTRMSTCGAGAAAPFANLVTHGFVVDEAGRKMSKSLGNVIAPAAFVQGDPAAPTDFPPLGADVLRWWAAKTDYTKDTPISVLIMKHVTDEVRKLRSTARFILANLSGYAPGSLPPFDTSNVAAGKGHLRLSLLDRYVMHELHRLETTCRAAYDRYDFAFVTRSLIEFATKTLSSLYFDAVKDTMYAGARDDQLPILAVMDQVLQTISSILAPILPHLAEDIHWYRGGATSDPTPEQAACMPSFFQLGWHTIEEHWCDPALEQRMQRVLRIRSEVFALVTRCKDEHLVKGPAETVVALYVLEDSLGALLHKHRSELADLMHVAHVDVYTEEVAWQRSAPAPSAWHRTCRVPDLQVDVRVEASQQAKCPRCWKYQSQTPDTLCERCMDIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1I8</accession>
    <name>A8Q1I8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730795.1">
        <property type="nucleotide sequence ID" value="XM_001730743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1I8"/>
    <dbReference type="FunCoup" id="A8Q1I8">
        <property type="interactions" value="635"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1I8"/>
    <dbReference type="GeneID" id="5855102"/>
    <dbReference type="KEGG" id="mgl:MGL_1794"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1794"/>
    <dbReference type="InParanoid" id="A8Q1I8"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="98"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="375" mass="41307" checksum="A372CFDA2D5F0E66" modified="2008-01-15" version="1">MCDYCMPIEPFDMAFHAEHGIKHLSFHAYLRHQNIGVPSSSASSSSSTYVPPLEEVSYRVKTPCPSGHHAPWPAGICTKCQPSAITLQRQPYRMVDHVEFVHSSLIDHVLDIWRKTATQRFGFLLGHYEPYEKVPMGIKAVIEAIHEPPQAGEIDGIELGLPWDDEPRITSLAAQCGMSIVGMIYTDLEVADPSHTDASLAGLVACKRHADSFFLSGQEAIFAAQLQAQHKNACRWTESGSFNSKFVTCVLSGNPEGDIDVSAYQVSEQVMGMVDADMIEASVHPTTIRVKPNDESRYVPDVFFRYTNKYGIDIKENASPTFPVEYLLVTCTHGFPTEPKPALLVVHLPDRESPGPAGPDARACLAWSSHTPNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1T0</accession>
    <name>A8Q1T0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730835.1">
        <property type="nucleotide sequence ID" value="XM_001730783.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1T0"/>
    <dbReference type="GeneID" id="5855142"/>
    <dbReference type="KEGG" id="mgl:MGL_1834"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1834"/>
    <dbReference type="InParanoid" id="A8Q1T0"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061245">
        <property type="term" value="P:establishment or maintenance of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000049">
        <property type="entry name" value="Cell polarity protein (Tea1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF456">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="608"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="84122" checksum="F417A8A4B5A3FAF6" modified="2008-01-15" version="1">MAIFGKKRSDKDRTAKQGSSDAPGAIVTDPNQIHANAPTLGLRLPSHTPQQQQQQQQQQQQQQQQQGGRTGFVSRIGSNPRSANDPRESFEDTSLMSHMVTDSSIRSPGRLQTAHVSSLSHTGGGTMAMPSGSIGHPSPGIAAATGLTSPGGVYGTPMTAGAAGVLRPSMDDGSRSSSQPTTAAAAAAAAALAQRQQQAPMPMTGELPNGSMPMPARTPPVAGAGAAAGXGPAMTTPPAPSTPERMRQANVVYPWGKKYVTMNPPRFLDETRRPPPGVLSPPPFPRYGHATNQATGSNHEVYIFGGLVRDSVKNDMYIMRIEPVQIQRSSGIKMDIALNATLVQTSGHAPLPRVGHAAVLVSNVFILWGGDTKMRAEDPQDEALYLLNLNNREWTRVLAPGVQGAPGPVGRHGHTLSIIGSNLFVYGGQVDDEYYDELWRFDLNTLKDTPVWQHVQTPTGGPPRRAGHSAVVYKERLYIFGGTDGQYHYNDTWCFDFASMTWSELKCVGYIPTPREGHAACMVDDIMYIFGGRGADGNDLGDLASFKISSHRWFMFAHMGPAPFGRSGHTMVSVQNRVLVIGGESFTGEAQDEPTGLHVLDTSKIKYPIKTERSGGSLSKSSTSDEAAMQPPPQSQSQLQSQLQPQPQPQPQPQSQPQSQSQLQPQLQPQLQPQPPTPESAHPTNPEHSSDVAHGAEAMRHSDPHSADGICAVDGGSRGRPIDRCWCSAGSRYTRLCPDTCTAHAIDTGTDAYDNDEQRSRAYTRVCDAIAAREGVEWADEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1W1</accession>
    <name>A8Q1W1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730848.1">
        <property type="nucleotide sequence ID" value="XM_001730796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1W1"/>
    <dbReference type="FunCoup" id="A8Q1W1">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1W1"/>
    <dbReference type="GeneID" id="5855155"/>
    <dbReference type="KEGG" id="mgl:MGL_1847"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1847"/>
    <dbReference type="InParanoid" id="A8Q1W1"/>
    <dbReference type="OMA" id="HERTHDP"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="378" mass="43163" checksum="A9303F39C626571C" modified="2008-01-15" version="1">MDPGQHAVSAQHAHDMLGVERGQPLSGLYRCESPGCDLLFFKRKYLRQHVREVHADSNCSEYPFVCEHEGCSQRFATNAKRRHHARIHEEGRYRCILPHSMPPPPNHPPYTVQCDMPGWSFSTWTHLQRHMRLCHPPTCSVCSRSYASRDQLKRHAVVHDATSSSLSTAESIDVAEWTCPWNGCEHVFLSRYALQVHVSRVHFGDKPFQCDVCGQSFGYKHLLRRHQMRMHESKVAAETESKADTGLELRPELLSHDHASSMQTSLDAGRAHTCSHGPSHLVRLMGMGRKRARRERILSCPWHVVCERNAHQDDSQAEEPLGLEPCPKKFARLYDVQRHLASVHGIELSDAELRSVMPENDIAQLPAPRVLKRLRTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1X0</accession>
    <name>A8Q1X0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730852.1">
        <property type="nucleotide sequence ID" value="XM_001730800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1X0"/>
    <dbReference type="FunCoup" id="A8Q1X0">
        <property type="interactions" value="712"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1X0"/>
    <dbReference type="GeneID" id="5855159"/>
    <dbReference type="KEGG" id="mgl:MGL_1851"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1851"/>
    <dbReference type="InParanoid" id="A8Q1X0"/>
    <dbReference type="OMA" id="EFLPYHW"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="10">
        <location>
            <begin position="384"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="513"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="617" mass="68768" checksum="66D2733DBFDB1786" modified="2008-01-15" version="1">MSQRDPRRGGKHADEALKRQADSIARNTRIPVSLQQSTPADTLGMRPPRSLSKIKDKKLRSELSRQYLSQKRAANHAKLADEYLHGTVPGEDAGMIEVDDEMERTARVTQAQIKDQVGVDTARKSFELKLGGKDQVGLGPYRCDYTRNGRHLLLGGRKGHLAAFDWQSGKLSCEIQVRETVRDVRWLHNNTFFAAAQKKYTYIYDQNGIEIHRLKDHIEVQRMEFLPYHFLLATIGKPGYLKYQDTSTGMMVASHRTGLGSCATMAQNPLNAVIHLGHANGTVTLWTPNMSTPALKVLTHRGPVTGLTIDSHRNGREMATCGLDGTIKVWDMRMLGKGPRREWTSRRAASDVAYSQRGLLGVAWGAHVSLYHTEAALGNAPPGPYMTHGLPQCTPLQLRFCPFEDVLGVGHAQGFTSLLVPGAGEPNFDTSEADPYETKARRREREVHSLLDKIQPDMITLDPDTMGQLDTRASRLSEGIVPAARTDRPGSVPRAADGTPYARLSRVQRLALSGNGDDNGDDAFVRAEEDSSVGHENRAPVVPAKGTTKEKKRARGRNSSMKRYLRKKRQNVVDANTIALREKYQREKARRREEQQPAPMKEPSALDVFARNRGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q203</accession>
    <name>A8Q203_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_1866</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730867.1">
        <property type="nucleotide sequence ID" value="XM_001730815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q203"/>
    <dbReference type="STRING" id="425265.A8Q203"/>
    <dbReference type="GeneID" id="5855174"/>
    <dbReference type="KEGG" id="mgl:MGL_1866"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1866"/>
    <dbReference type="InParanoid" id="A8Q203"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="17">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP43653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="212" mass="23479" checksum="21C8B91371B06CA0" modified="2008-01-15" version="1">MTDAGEATGSRSWYSYVAAPMVGQSDLAFRLTAVQYGATATWTQMYHTEDILYHNETYEKALRALEMGSAARENCDIVTGERAPQIVQLAGDDPEQFVQAARRFLPIADAIDLNLGCPQARARDGHYGGYLLKRREWPLLERIVQALCKSCDVPITTKIRLCDTASDTYELGQRLALAGSSVITLHARHVAPNRRRAGMAKLEHVQNDAHAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q231</accession>
    <name>A8Q231_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell differentiation protein rcd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730879.1">
        <property type="nucleotide sequence ID" value="XM_001730827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q231"/>
    <dbReference type="FunCoup" id="A8Q231">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q231"/>
    <dbReference type="GeneID" id="5855186"/>
    <dbReference type="KEGG" id="mgl:MGL_1878"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1878"/>
    <dbReference type="InParanoid" id="A8Q231"/>
    <dbReference type="OMA" id="IFIVQKF"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000014">
        <property type="entry name" value="Cell differentiation protein RCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34445" checksum="D6D60A0D662C2139" modified="2008-01-15" version="1">MGDAHMQSTMVQGADAMTALDLHHLISQFCQRPDPMDMMSANAHALPGSSVQREHALLELSKKREQYEDLALVLWNSFGVMPSLLQEIISVYPLLSPPVLTAHASNRVCNALALLQCVASHNETRGPFLQAHIPLFLYPFLNTTSKSRPFEYLRLTSLGVIGALVKQNDKSDVITFLLSTEIIPLCLRIMETGSELSKTVAIFIVQKILLDDLGLNYICQTYERFYAVGTVLSNMVAQIVESQAVRLLKHVVRCYLRLSDNPRAREALRSCLPTPLRDATFSQLLKNDHITKRCLATLLLNLSDRAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q270</accession>
    <name>A8Q270_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730701.1">
        <property type="nucleotide sequence ID" value="XM_001730649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q270"/>
    <dbReference type="FunCoup" id="A8Q270">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="5855007"/>
    <dbReference type="KEGG" id="mgl:MGL_2155"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2155"/>
    <dbReference type="InParanoid" id="A8Q270"/>
    <dbReference type="OMA" id="QANWKWS"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="428"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="631"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="746"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="643"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="781" mass="86000" checksum="86E54256538A1000" modified="2008-01-15" version="1">MFSNKKSALDCTATLPLVNSLNHFAYLASTSPRIREMVMLDGGLERLIHILRRPPQNVSGMMMFDRASSSLNEIQANWKWSLAFQCVVNIGVRGSEAIRTRVVEAGMVPIIIRVLDNYLMTSDLIHIQQRKALAAVREWPASRQGSHHSLYPPQPATVSTVPRPATPMDMDTIHPPAEHTYWTVDADRQASRELLPLHNRIAGDASASASASECAEDTEMFHEEGASPSASELLAPKNDAPESETPRAPRTSTLRAEADSHIDMAHTPRAGAHNATMPDAMQQDEDVHLWQTPTPVLNPREVAPVPPPVYREEEVLLSLQLLAYLSKYPHVRHFFHNADVREDMIFCPEWPEETLPNRSWQPSDLPQSNVFSVAERFTHRPTRSSTTPNVLCSLYPRLAPDIKYWAGVVMRNACRKDESRGGIRQCANMLCGKWEAYPREFAKCRRCRKAKYCSKQCQSKGWQMGHRFWCSARSDDDKTRGTHESRSNVHTSVALDVSPNNDGHAAGTTQLPRDPTNARSERDTVYSRPLGPRHVPSTFRENQMPSLRGVSAASADSTDLTELSDDGTRQGETSSTTSPAGTNHASTAAAQRTLPAPVIAGDLTIQEADPATATLQAQEAQNIQEHGPLDIVAASWPPPPPSVVSSTSAADMTPSLQSQPQSQSQSVQPSVRSTTETHFDLGITLPSSGQLTTSHIHDGDHSVSTRSPYTSPWQNMATPTAFRSAHHAPRAMSMFSTVTSSPVAIGDETVHEDPPAITPTSQWLPSWHAHDTEPSRLSDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2V2</accession>
    <name>A8Q2V2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730446.1">
        <property type="nucleotide sequence ID" value="XM_001730394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2V2"/>
    <dbReference type="STRING" id="425265.A8Q2V2"/>
    <dbReference type="GeneID" id="5854753"/>
    <dbReference type="KEGG" id="mgl:MGL_2242"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2242"/>
    <dbReference type="InParanoid" id="A8Q2V2"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7736" checksum="15FEA4F3AB7AA868" modified="2008-01-15" version="1">MKSYWLMQFDTNAPTLKVLNDRLRQDPRVIKWNTLKLGEKLRELVPPGASGGTTPSQSTMGGRTVDYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2Y7</accession>
    <name>A8Q2Y7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730475.1">
        <property type="nucleotide sequence ID" value="XM_001730423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2Y7"/>
    <dbReference type="FunCoup" id="A8Q2Y7">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2Y7"/>
    <dbReference type="GeneID" id="5854782"/>
    <dbReference type="KEGG" id="mgl:MGL_2271"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2271"/>
    <dbReference type="InParanoid" id="A8Q2Y7"/>
    <dbReference type="OMA" id="IEMFVAT"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="237"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="700" mass="77224" checksum="F792E08F2844CA51" modified="2008-01-15" version="1">MYASKSAPPTGFRPLPEPSVSWRAEDVEEARRVTLLRDMSFREDEAAALPSLQASLKQMRYDRIKIEEEQRHVGAMIPSLAKKVNTNAERVSQLRERARELRTALRYLEKQMDEAHARSLQIRSAWPNRMHPDVPIGPESESRVVAVCDARSPACRSTSLPTTLLPCTTHAFDASFTSKLQVDPRRDHLGLAQSMSHGGVDMAAGITTTGPSWPYLLGTISMLEHALCQYALHVATRHGFIPVSVPDVIKTDVAERCGFRPRDEVAAQTYFVDTKRSITTHDTSACDDAMATLCLAGTAEIPLAALVAKQTFSHRHTQPNLGGDVASMHLPIRLTALGHAFRAEAGARGADTRGLYRIHQFSKVEMFVVSDAEQSDAMLESLRHVQEDIVNGLGLLYRVVDMSSEELGASAYRKYDIEAWMPGRGAWGEICSASNCTEYQARRLAIKYRDAETGRNTYAHTLNATAAAIPRLLVALIETYSSSNLVLPVALRPFWIGGPSDTRVEWIEPASVAASAPASSGERASPLQQCGTSHPRASFHTSARRNVSAFTRAKEQLHSLAVRTGADPAPLLISFVILHEITAIVPIFVLAALLAVLGAGDAMLEWVNTLLNAMMPSENARLYEWIARGRRMATRVCRRFDTLLRGKEGTPMAAAWFTSLTASYVLVKLLLPVRIALSLALSPVTARTLIMPWWRRFRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3B4</accession>
    <name>A8Q3B4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2353</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730557.1">
        <property type="nucleotide sequence ID" value="XM_001730505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3B4"/>
    <dbReference type="FunCoup" id="A8Q3B4">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3B4"/>
    <dbReference type="GeneID" id="5854864"/>
    <dbReference type="KEGG" id="mgl:MGL_2353"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2353"/>
    <dbReference type="InParanoid" id="A8Q3B4"/>
    <dbReference type="OMA" id="NVPDHEP"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="11">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="319"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="414"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="66074" checksum="0F8CE63F250821A5" modified="2008-01-15" version="1">MATSAVYYRFRSQREPQRLTFDGTGISVWELKREIILQNKMGKGTDFDLAVYNADTDEEYKDDNYTIPRASQVIVRRLPPSKPGRGTAQLYVADMQSTATANGSVPSTSMAPNVPSQSMPYRGPMSKRFDGRDAPSSSTAASAMPAAAIQSAAIDNHQDEASKIAAMFQASTEQWEETQERMSHATYRERSGAPRRGPPPGRDGGGYAMSAIERRPPPPGFICYRCGQKGHWIQDCPTNDNPEYDNRRFKRTTGIPKSMLKTVEQSTAENMSGVMVTPDGSYVIATPDSSSWQRSRARSRPLSKTDVYQSVPSDPALACPLCSKLVRDAVKTSCCHTSFCEECVQTHLFEHDFVCPECEKRIPDIEMLKIDDVLRKLVREYVEKTIARSEEAFEQGTGVDEEAAQQAAVSEFAAAGSVSDSKDRASSGRDPAVSKDVASNSTATADHGTSAKAAEPESGSTPTVAPLAAIADDASATAKGSMPMLGAGPSVGPGSGDGAPTFHPQTVQQIVMMLQNPQLPMPMRMQLQMQLQFQQMLFFQTFSSGAPTGMPPGMPPGMPPGMPPGMPPGVLPGMPLGMPPGMPPGDLSGQDAAKRPHAEGESSGRKEKQARYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3F8</accession>
    <name>A8Q3F8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730590.1">
        <property type="nucleotide sequence ID" value="XM_001730538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3F8"/>
    <dbReference type="GeneID" id="5854897"/>
    <dbReference type="KEGG" id="mgl:MGL_2386"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2386"/>
    <dbReference type="InParanoid" id="A8Q3F8"/>
    <dbReference type="OMA" id="VRNCTAK"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051012">
        <property type="entry name" value="CellSynth/LPSAsmb/PSIAsmb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45586:SF1">
        <property type="entry name" value="LIPOPOLYSACCHARIDE ASSEMBLY PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45586">
        <property type="entry name" value="TPR REPEAT-CONTAINING PROTEIN PA4667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="138" mass="15086" checksum="500D1516C1FAE38A" modified="2008-01-15" version="1">MYHFDGYIYDNADDLEGAIASWNAALRLAPDSPDAHTNLASAYIMSKPPQADKALEHLITAASQSPDDGEIHFNLGTVLEACEQLESAIDAYKKALKNGVDRADQNVRNCTAKLLSARLDVQRQQKEIDAKKAAKADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3G0</accession>
    <name>A8Q3G0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SDE2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2388</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730592.1">
        <property type="nucleotide sequence ID" value="XM_001730540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3G0"/>
    <dbReference type="FunCoup" id="A8Q3G0">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3G0"/>
    <dbReference type="GeneID" id="5854899"/>
    <dbReference type="KEGG" id="mgl:MGL_2388"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2388"/>
    <dbReference type="InParanoid" id="A8Q3G0"/>
    <dbReference type="OMA" id="DHEYVEQ"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDE2-like" evidence="10">
        <location>
            <begin position="73"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="248" mass="27243" checksum="4EB48A9695C731A5" modified="2008-01-15" version="1">MCEPYDRTVKISLARSTSCATLYDRITAVLGRNSDIVRLTSRGGHSICPSYTLNELAGVYPCVDLELRVRHLGGKGGFGNMLRAQGGRMSARGKHESQDSCRDLQGRRLGSIKEAQLLAEYIAKEPDRKAALDEAQKRKYAKLERMLGREPKSMDDFQEAAEKLEEAGDSLDASHESAPSSSASASASVNETRTASAPKRKERLDDHEYVEQSREIVDNVRGAVAAAMKKRKGKKRAIDNVDKKATAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3G2</accession>
    <name>A8Q3G2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">S-adenosylmethionine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730594.1">
        <property type="nucleotide sequence ID" value="XM_001730542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3G2"/>
    <dbReference type="FunCoup" id="A8Q3G2">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3G2"/>
    <dbReference type="GeneID" id="5854901"/>
    <dbReference type="KEGG" id="mgl:MGL_2390"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2390"/>
    <dbReference type="InParanoid" id="A8Q3G2"/>
    <dbReference type="OMA" id="IGPRTMW"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="103"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="195"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31024" checksum="2AEB81BE694A3A8E" modified="2008-01-15" version="1">MEAEHVEEAQRVHPGFVTALLAGAASGLSVDLLFFPVDTIKTRLQSAEGFWRSGGFAGVYRGMGSVAVGSAPGASIFFVTYEMSKSMLARVIDPDNSMDAKISSPAVHMAAGTIGEMAACMVRVPTEVIKSRQQTSAYGRISSFHAFRHVVAQEGGRGLYRGYGSTIFREIPFTCIQFPLYEFLKQHMAGYKHEPTWWQAASSGSIAGAVAAAVTTPLDVIKTRIMLSKVTPGTPHGPSARILPMLSHVIQEGGIRALFAGVAPRTLWIGVGGAVFLGTFDVTAKLLERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3H5</accession>
    <name>A8Q3H5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">signal-recognition-particle GTPase</fullName>
            <ecNumber evidence="11">3.6.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Signal recognition particle 54 kDa protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2403</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730607.1">
        <property type="nucleotide sequence ID" value="XM_001730555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3H5"/>
    <dbReference type="FunCoup" id="A8Q3H5">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3H5"/>
    <dbReference type="GeneID" id="5854914"/>
    <dbReference type="KEGG" id="mgl:MGL_2403"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2403"/>
    <dbReference type="InParanoid" id="A8Q3H5"/>
    <dbReference type="OMA" id="MTIFVMD"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="416"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="617" mass="66825" checksum="743D48824BF6B7C0" modified="2008-01-15" version="1">MVLADLGRRLNQAFSDLQRQPTLDAASVDQLLKDVCSALLASDVNVRLVQKLRQDVKDEVSSLLNDKGKAESYTDAQRKHQVQRIVFDYLVKLVDPGDGSTKHRLDKGQQHVIMFVGLQGSGKTTSCTKLALWYQKRGYRTGLVCADTFRAGAFDQLKQNAAKARIPFYGSYTETDPVAIASAGVTSFKKNRFDVIIVDTSGRHKQEKDLFAEMVDISRAVKPSQTIMVLDASIGQAAEAQCRAFKEAADFGAMFVTKLDGHAKGGGAISAVASTQTPIIFIGTGEHVHDLEPFRARPFISKLLGLGDLTGLMDKMEEVHMNEDVQQRQRDMMKKIQEGGTFTIRDWREQITHIQSMGPMSKMAGMIPGMSQMMGHAPSDATANDKFKIMLYITDSMTPEELDSDGSCFTKPIKTSTSRAAAARSHSDEKAQSRTAANTNANANDKTKSKAPLRLTSRALRVARGSGTSVRDVEEFLMQYRTISQMVKKFGGKNSWLQQMKSGGGSGAGAGRGGMPMLPPGMTREQAMKMQNALPADIKAQLRQPGGREQLMRQLQSGNVPPSLAAMGGLPGMPSFPGMGLGGAAGGMPDLAQMQSMMQNMGGLGGMMQKMMGGGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3I4</accession>
    <name>A8Q3I4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2412</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730616.1">
        <property type="nucleotide sequence ID" value="XM_001730564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3I4"/>
    <dbReference type="FunCoup" id="A8Q3I4">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3I4"/>
    <dbReference type="MEROPS" id="T01.012"/>
    <dbReference type="GeneID" id="5854923"/>
    <dbReference type="KEGG" id="mgl:MGL_2412"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2412"/>
    <dbReference type="InParanoid" id="A8Q3I4"/>
    <dbReference type="OMA" id="NLGMAMQ"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="295" mass="31865" checksum="237C974493EDDB79" modified="2008-01-15" version="1">MNSVLAKFARDDLSVPCVQDEDLGALGNGFALPASDPSRFLAQYTDVDSTRPDARIKLNHGTTTLAFRYKGGVVVAVDSRASAGSYIASGSVKKVIEINPYLLGTMAGGAADCQYWETYLGIQCRLHELRNKERISVAAASKILSNLVYSYKGMGLSMGTMICGWDKSGPAIYYVDSEGSRMKGDLFSVGSGSTFAYGVLDQGYHWDLSEEEALDLGRRSIYAATHRDAYSGNTINLYHMGPNGWRFIANYDVMQLHYDGVSDQVPNAPSGGYGYNVRTAGLSSRDESVSGQSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3K4</accession>
    <name>A8Q3K4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Poly A polymerase head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730635.1">
        <property type="nucleotide sequence ID" value="XM_001730583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3K4"/>
    <dbReference type="FunCoup" id="A8Q3K4">
        <property type="interactions" value="556"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3K4"/>
    <dbReference type="GeneID" id="5854942"/>
    <dbReference type="KEGG" id="mgl:MGL_2431"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2431"/>
    <dbReference type="InParanoid" id="A8Q3K4"/>
    <dbReference type="OMA" id="QEEAICQ"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="6">
        <location>
            <begin position="40"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="7">
        <location>
            <begin position="256"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="65683" checksum="AF9CB01F64B41C29" modified="2008-01-15" version="1">MQASNPSVEVDGQVHTYKDLCIGSDASDQPSSASTITCEARIAGGWVRDKLLGLPSHDLDVSLSSLTGHQFALFLKAYLESDRFSQTKLAHEIAMHLPHRGPMGTIGKIAANPEQSKNLETATTNVLGFDLDFVNLRKEVYEGTHRIPVMSFGTPLDDAMRRDITVNALFYNVHTASIEDWTEHGLHDLHHGIVRTPMDPASTFNDDPLRILRCVRFSSRFGYEIHSDIRSCLCETASDGGSKAKNPSTAELLRSALLNKVSRERFGIEVDKMLSGRDPFRALQLLSELGLYKVVFTPPPPLIQRMGTSSGGAQIDAPADIPDENVALFLAACFDDLLQGTGTYADLWAHIPHDWLDTLRTSPTAASKQRLIWYALALFPLRDIYVQPKKQKEWAGLETISKGLKLGNRNTKDPVACLDRAVSVLSRPSLDRFKPDSCLTQRSTIGLLLRQSCITSPSLDVGLDNTLLFALFCDLATVYDAQNDTLDKDSAINIIDEYARFWAFVRDERLLDYAQVKPILDGRQVAEALPCEKFLLTRVLPFVVAWQIDHATMDAPLAERQAQCAKDLHDAWSSGHLIPVSERTQVAKSKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4A4</accession>
    <name>A8Q4A4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_2516</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730134.1">
        <property type="nucleotide sequence ID" value="XM_001730082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4A4"/>
    <dbReference type="FunCoup" id="A8Q4A4">
        <property type="interactions" value="640"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4A4"/>
    <dbReference type="GeneID" id="5854441"/>
    <dbReference type="KEGG" id="mgl:MGL_2516"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2516"/>
    <dbReference type="InParanoid" id="A8Q4A4"/>
    <dbReference type="OMA" id="LDTWMDS"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="17">
        <location>
            <begin position="124"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="18">
        <location>
            <begin position="798"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1049"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP42920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1080" mass="120942" checksum="9DA0DF19241178F9" modified="2008-01-15" version="1">MSQPPSVQHTSPEGVPPSEVPAAATAAAESAAAEGGAEGTSKSAQKKAAKLAEKQAKAAAKNALKAEKAPASAGASSGAPKKEKVKKETKEEPAWTDPTKPGEQKDLSAPMESGYNPLHVESSWYAWWEKKGFFTPKPPSDAAPYDPAKTFVIPLPPPNVTGLLHIGHALTISIQDALIRFYRMKGYRTLYVPGFDHAGISTQTVVEKRLAKVEQKSRYDYGREAFLQKVFDWKDEYQARISNQMRRLGASFDFTREAFTMDASLSEAVTENFCKLFEDGILYRENRLVNWCVYLNTTLSNLEVVQKTIPGRTLMNVPGYPPNERIEFGVIVSFVYPVVGSDDKIIVATTRPETILGDTAVAVHPDDERYKHLHGKLLQHPFIAERHIPVVTDSVAVDMAFGTGAVKITPAHDPNDYDVGKRHNLPFINILNDDGTLNANAGEFKGMKRFSARRAVVDALKAKGLYVETKDNPMVVPVCERSGDVIEPVMKPQWWVNCQPLAKAAVEKVRQEDMAIEPPQSKREFFRWMENIQDWCVSRQLWWGHRVPAYFVDMEGVEQDASEGRWWVVGRTREQADERAAKMANGRAYELKQDEDVLDTWFSSGLWPFSTLGWPRANTDDMKYYYPTSMLETGWDILFFWVARMIMLGVYHTGQLPFKEVFCHAMVRDAHGRKMSKSLGNVIDPIDVIEGISLEGLQQRLREGNLDEKEINKAAQGQKKDYPRGIPQCGTDALRFTLCAYTAAGRDINLDIMRVEGYRKFCNKLWNATRFALLKLQDGYTPLPLAEQDAFVPQSLVEKWILYRLNATAKQLDHDMQQRSFMSATSCVYNFWLYDLCDVYIEAIKPITDAGAEPAARLSAQHTLYACLDAGLKLLHPFMPFVTEELWHRLPVRPQETCETIAHTRFPPWNPTHDFAAEAAQFDDVFASVRAVRALAADYGLTSKIQAFVEVQNAESRHVLSTQCSVMHTLIKGCESIVCVSQASEVPAGCVVASVSATIQVHLLVSGLVDFDQELSKLAKKLTLNETQLQRTVALTQKPDWSKTPEDVRASTNQRLDDLEAEKAALLKAQANFESLRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4L7</accession>
    <name>A8Q4L7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730186.1">
        <property type="nucleotide sequence ID" value="XM_001730134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4L7"/>
    <dbReference type="FunCoup" id="A8Q4L7">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4L7"/>
    <dbReference type="GeneID" id="5854493"/>
    <dbReference type="KEGG" id="mgl:MGL_2568"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2568"/>
    <dbReference type="InParanoid" id="A8Q4L7"/>
    <dbReference type="OMA" id="KKWAGAK"/>
    <dbReference type="OrthoDB" id="5390558at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="120"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="332" mass="34449" checksum="BBC9BB8B66225493" modified="2008-01-15" version="1">MSVAMNNPFHLLGVDGSEEAPAAQAASTGAGPQASKPKTQSAPAPAMTQRYVPGAPRQTAPKVPVSDEPLPRDSVEVRDTRGASRARGERGGGRGGDYRERGGRGGGRGGRGGRGSGRGGGRQFDRHSGTGREETEKSVRQGWGGVDGASAQKQEQGAKEDAKHEAEQNAQEDAADKKAEREAAQPEPEQDKTLTLDEYLKSQAEKRPQLAASAPRTVQEDESYGQRLDRGEGESYFAGTEKKTSAPRPRKEKQLVEIDPVYTSPSMSRGSGNGPRGGGRGGGRGGRGGARGGRGNGRGGRGSGRGGRSGGRGGNQGPVVNLADENAFPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4S2</accession>
    <name>A8Q4S2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730240.1">
        <property type="nucleotide sequence ID" value="XM_001730188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4S2"/>
    <dbReference type="STRING" id="425265.A8Q4S2"/>
    <dbReference type="GeneID" id="5854545"/>
    <dbReference type="KEGG" id="mgl:MGL_2622"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2622"/>
    <dbReference type="InParanoid" id="A8Q4S2"/>
    <dbReference type="OMA" id="VHARWAD"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="217"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="334" mass="38735" checksum="5DA1AB2F68B0D9D8" modified="2008-01-15" version="1">MSRTAAAVEDETEAMQQDEVDAQNNEYEQQDEEIDYEEGEPESEGEYMSDSEEFDELVDEIDESDSPPETNRRARRQPLRVRLTRKSTPQSTPSRRASTSAPRRSSRTKSTRSSHKNASRKQRDVYTEERDEDDELVGDEDEEEVNEDNMNDEEEEGDLLDENEDDDEDEDEETTSDMPMTARQIARANRARGIANEELIELPMEDSSRKKKLSETELALRRSETARRRRNQSEKKLEDDKIETINRLLKKQAGKVRGRDKSEGDTQEESAAKKPRDMAANHPQPFFRYIQRADRSILAVPLGPPFRDPDETEGLYDYTLRTAFRMSREAWSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4S7</accession>
    <name>A8Q4S7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase DOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2627</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730245.1">
        <property type="nucleotide sequence ID" value="XM_001730193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4S7"/>
    <dbReference type="FunCoup" id="A8Q4S7">
        <property type="interactions" value="766"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4S7"/>
    <dbReference type="GeneID" id="5854550"/>
    <dbReference type="KEGG" id="mgl:MGL_2627"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2627"/>
    <dbReference type="InParanoid" id="A8Q4S7"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="128"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="362"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1046" mass="117428" checksum="56A17ECA3A828D55" modified="2008-01-15" version="1">MGKRGVDSASKAPLASGSKPDAKKVRTTEPAAVVTDEFTAEATRKVPSLHDTEINSKSTKDSTKSEGDGTESSIPAEAAETLQLSHSVRHQVAIPAGYDYLPLSKHVPRDPPSRSWPFELDPFQRTSVYCIERSESVLVSAHTSAGKTIVAEYAIAQALRDGQRVVYTSPIKALSNQKYREFSAEFGDVGLMTGDVTINPSASCLVMTTEILRSMLYRGSEIMREVAWVVFDEIHYMRDKERGVVWEETIILLPRKVHYVFLSATIPNAMQFAEWIAHIHAQPCHVVYTDFRPTPLQHYLFPEGGQGIHLVVDEKGVFREDNFQKAMGALSEVRGDDPASTESGKGRKGQSKKGGGTSGPSDIYKIIKMIMLKQYNPVIVFAFSKRQCEALALQMCKLEFNTDDEKEMVSTVFRNAIDALSEDDRNLPQIEQILPLLRRGIGIHHGGLLPILKEVIEILFQEGLLKVLFATETFSIGLNMPAKTVVFTAVRKWDGNEFRNLSSGEFIQMSGRAGRRGLDDRGIVIMMFDEKLEPSAAKLMVKGEADRLNSAFHLGYNMILNLMRVEGISPEYMLTNCFFQFQQAASVPELESKLADAEERRDAIHVPDEDDIAAYYTMHKTLAQLDDDRREVLRHPSYALPFLQAGRLVNVRHEDVDFGWAIVVAYHKRMPPKGQEFDPRAPPHSLYVLDVLLHCAAGTIVPKQRESAPSFSGIEPPAKGSHGNGEWLVVPILLSHVEELSGIRVFLPKDLRLRDARAQVGKNLAEVCRRFPSGLPLLDPVKDMKIDDVSFQQLLGKMEILQSKMKQAPITQDKPRFEELFALYKTKQAAADQVKSIQDQIHVAHNVLQLDELKCRRRVLRRLGFTSSEDIVEKKGRVACEISTGDELLLTELMFNGTFNELLPEHCAALLSCFVFGERSEHPVRLKEDLAAPLRILQDTARRIAKVSVECRLPVVEQEYVQSFKVELMDAVLQWCQGARFADICKMTDVFEGSIIRAFRRLQELLRQMAMAAKAIGNDELVHKFEQALVKLERPNSIIFSPSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4V1</accession>
    <name>A8Q4V1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730264.1">
        <property type="nucleotide sequence ID" value="XM_001730212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4V1"/>
    <dbReference type="STRING" id="425265.A8Q4V1"/>
    <dbReference type="GeneID" id="5854569"/>
    <dbReference type="KEGG" id="mgl:MGL_2646"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2646"/>
    <dbReference type="InParanoid" id="A8Q4V1"/>
    <dbReference type="OMA" id="CCGQIMY"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF6">
        <property type="entry name" value="GB|AAD46013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="68279" checksum="B725A87472596F8E" modified="2008-01-15" version="1">MTDMSRQQPSQHPKKSQQVMPGALTTLEPVACPDDEDSSEEFELPSNSSTPNLSEAMENIKRSMSFTTFQQISSKPPGEVRRQIQKKLWRPHDDETKIPNDWERLMVHVIRAASRAFTLAYGIRSSLEFLFVFIKVLRSRKPIKKSDLKAAFVGERTVRFALTFGAWAAIYKFTNNALRLLTTPTRSARPLGARRSRSVPEGSMKVDDNGELTLMTKEKSNVQKKKAVWKHISAYDPRARKWHAYLAGAVSSLALLIESREFTRSFGLQVFVRGMEGVCQLASRAGYINIPYASILIFGLANVQIMIAWLGSPHLLERSYKNWIDKASSVPKPALELYRQSVNGGMSPWDMVTLFGGVVPEPVSTNPVKFADLPPNKYALYGVSGDVLAKVHRWIEHGNPPRYATCAIQHPQTTNHLFASVRNFVATWKFVMPVYLTLYVVPTVFLRPKALRKAPAETIMRSLLGASRSSSFLAVYVFIVKSMFCLVHVLADGISYSRLNDIPFMRRVSELLIDNRMKGLGGFLSCLSLFIEDRRRRKELTLYVLPKALESFWATGRIVGYIPHVPLGEYIMAATGLSMLMGSYAQNPDNLSKLVSLIIYQFIGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Y9</accession>
    <name>A8Q4Y9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730294.1">
        <property type="nucleotide sequence ID" value="XM_001730242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Y9"/>
    <dbReference type="STRING" id="425265.A8Q4Y9"/>
    <dbReference type="GeneID" id="5854599"/>
    <dbReference type="KEGG" id="mgl:MGL_2676"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2676"/>
    <dbReference type="InParanoid" id="A8Q4Y9"/>
    <dbReference type="OMA" id="NHFESCA"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="521" mass="57996" checksum="337AC96E712D71FC" modified="2008-01-15" version="1">MRIGTYAPRDEDVVLTPSSAHSVLNLRRWLELLGSELDYGYTTTEQPRGNSHILHSRARVLGGCSSHNTLISFFPFDADLDNWRDYHGCPDWGAKAIQPYGSRLKMNIVPIAPQQRNHVVRDWVKASAEATGAPVMEDMNAQIAYRGGFDQAVGFFNISYDPYNGHRSSASTAYMHPIMPHGATPRKNLHLFLETWVRALEFDAHDPLRVRGVRAEQKNGTSSVIRARREVILCAGAFDSPRLLLLSGIGPKSELEAIGIPCRHDLPGVGLNLNDHPESIIIWETRDTPSETVMSSDACLFLRTQPRDAEPVPHPGPDLMFHIYQVPFTENTARQGYPVPKHAICMTPNAMRSRGRGKVSLANADPTTKPLIDFKYFQDEDHYDERLMVEGIKIARKVAEHQLFRQHLVREVAPGPACQSDADISAYARSVAHTVYHPAGTCRMGTPPSSHAPASEDARTVVVDQRDLKVVGMKGLRVCDASVLPTLPSVNPMLTILMVAERGAELIRNDAWVNGERRTDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5A1</accession>
    <name>A8Q5A1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Serine/threonine-protein kinase rio1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MGL_2761</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730379.1">
        <property type="nucleotide sequence ID" value="XM_001730327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5A1"/>
    <dbReference type="FunCoup" id="A8Q5A1">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5A1"/>
    <dbReference type="GeneID" id="5854684"/>
    <dbReference type="KEGG" id="mgl:MGL_2761"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2761"/>
    <dbReference type="InParanoid" id="A8Q5A1"/>
    <dbReference type="OMA" id="IGHVDEY"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="157"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="535"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP43165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="626" mass="70574" checksum="F4286B20A30F2A4C" modified="2008-01-15" version="1">MHLPCSDFTKQYNRARQMATALQNPTNDAQTAMPAVNRARLRASKVAHERAAASSTIGAGLLSHDHSAPSDDAAMHSSKTAAQIAALSKYTARIHIDDAYDPSRVAGGSVDARVPRKTNKLEVNRRKDKADRATLQQVLDPRTLLILSKMIRRELISEVNGCISTGKEANVYYAVRPPLEPGQPPRSVAIKIYKTSILVFKDRDRYVSGEFRFRHGYARHNPRKMVRLWAEKEMRNLKRLVNAGLRAPAPVELRDHVLVMEFLGDDDGWSSPRLKDAEALIAPEDWTRLYRELVATMRLMYHQCRLVHADLSEYNILLHDNHLWLIDVSQSVEHDHLHAFDFLREDIAHIDAYFSKHGVETLGMRQTFHFIVKESTRSRGGGVAGLEKLTQSNENDEQIQSTVLAPSTTQRPASWHDNETEESLIEELAHFTKESAQTAAAAVSSKTGPSLVSSLVDQMDDAQKEETEESVFRQSYLPRNLDEIADPERDADIVRSGQVHSLIYSGVTGLDDVYQKSEQKEHQIDKVDYYDESDIEAEDAESGVNKSESEQEVGPDEQRSKEREERKVSFCLLSIGANDPESQKTSQRRKSRASQNQDAQGREKATNEKDIRSKISSLLRLATKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5V3</accession>
    <name>A8Q5V3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729834.1">
        <property type="nucleotide sequence ID" value="XM_001729782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5V3"/>
    <dbReference type="GeneID" id="5854141"/>
    <dbReference type="KEGG" id="mgl:MGL_2820"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2820"/>
    <dbReference type="InParanoid" id="A8Q5V3"/>
    <dbReference type="OrthoDB" id="3364052at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="433" mass="48526" checksum="1A2D2E3778FDF2BD" modified="2008-01-15" version="1">MTETPRHSVGTESHHSTISSDYKRRSEIHEVEVMRLLAEGRLHSTPRSTSPNIRRPKAWKDIPASISSKSLDQSFEHPHDSPSVGAKMRRDRFDRREGEASNIRPDPADLGEEYLHGQKTVRRWPHSVPSKSSSLIPKTSFQTPRSTSLDSLAARMQDAHLESPVAFTSLDPSQSKSTSKIYTRPIVNAPASGMPSRHRQNMHLALAQCRKQRESCTGGPGLSTELMEQLETVANLTDTVNQGLRRLLMRVLDARMGEQWISDPEDASDLGSAAYLDAELGKLLNYSDDNVRSMTDALLLILRERRSTQVSNTAFDKPSVPNTSSMYYYTPRQYRQQKAMSIGPTSETFRRPHDASKFTRRRSQPMAELLHEPLFPHAAPRGTTRTFSPTNHSHSSPLSSLPMSSLWSAGGPASLTDRRPDMHLRHLGGYDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6A9</accession>
    <name>A8Q6A9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729919.1">
        <property type="nucleotide sequence ID" value="XM_001729867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6A9"/>
    <dbReference type="GeneID" id="5854226"/>
    <dbReference type="KEGG" id="mgl:MGL_2905"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2905"/>
    <dbReference type="InParanoid" id="A8Q6A9"/>
    <dbReference type="OrthoDB" id="2555519at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="372" mass="40856" checksum="E4BF551D06C8EFD5" modified="2008-01-15" version="1">MRMANATTRRSAQELQAKVSPTMRSAWIEPDVPASDAIKTQASPLLPSAKIPMPSSRPSNSAQSNIDKPLRPARVYSGQRSATTTLVSPTSSSIHVSSLESMSSFPNPNEHEAEMKFRSEFEPPFFIGRHSSLATSPSNVYSAKSAHGQERTRMNLDVSSAPVLTSLRARTAQPNIPITASDTSGSWSEHMMQSLPVSSSSPPIQDNASFLQSPQCSIPGDDIMESSEVLDAKQARKLLDLEISNKSLLAINTALESSKVKLTKELRELRQSMVFQNLPIEPDSKNMTQEPIPFVTDPQQSTSMSDKPRVGSQVLQLFMRQDQELEEIHERCRSKIDDLLNQARTAIFSQPDVGDVPLGVKVLHPSETKVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6B3</accession>
    <name>A8Q6B3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2909</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729923.1">
        <property type="nucleotide sequence ID" value="XM_001729871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6B3"/>
    <dbReference type="STRING" id="425265.A8Q6B3"/>
    <dbReference type="GeneID" id="5854230"/>
    <dbReference type="KEGG" id="mgl:MGL_2909"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2909"/>
    <dbReference type="InParanoid" id="A8Q6B3"/>
    <dbReference type="OMA" id="DTWYSAT"/>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="363"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="462"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="760" mass="81861" checksum="BF6285F6FF456CB8" modified="2008-01-15" version="1">MGRAVLERVTSERDQRDDGLLADPFFKLPSQRQYPEYYVVIRRPISLAEVRQKLKQKEYAFLQDFKQDLELMCTNAKRFNVRDSDIWLKARDLHSLVKDACAEAYDEWLSHADQRLEKVPMRSHKITLRAPRSSTVEAPVIQTDKKTNPATTDAPMVSSSSTSAPSKPEVHASENGSKPMPAQDSAVAPTPGSAGAVEVASAAAPDTSATPEAASPHTPATPAKMAVPSTSVSQTASPGPAEHAEQSASSAPAASTTSSTPHTSAAPAKTTTTTPMSTASTSRPSTMTPGLATSTPDSQRTYSPTVARIIESASQPNQSPTVPSPTTASYLAERRRRGAPRGKRLKAMLRWAVQNMVAAQDLQGHAYSEMFMELPSRDEYPDYYQFIRQPLCFADIERKLDLKEYINPHALVSDIRLMLSNAQFYNEEGSQIWNDAQALWRHLDNVLIPGLLAEGFTLDPNDHRQAALPPGTPGAVPPPPPSVSAQTPPIVHVRNPMPTTSTTATPLPAKAPTQSHTQTADMMSVQTPGSMTSPIQMPISRMPMAGPKLMPKQMPSAPEATSSASASASASVAPFPTTKATVSILGSARPAGVHAISTPTTAAAVPSTAVPLDRVIRDMDSKTWPPHPTAFLAPDSCMSEKESSAGLATHPLPPWTSLHVYTDGDKSQAHAHIRLDTCPSHALALPPGTRSTQWRWIVDKDMPQAGVRVLLDGLEAQGHWDGSSYAVTWNMPAGEHVLEALWFRDNGSPAGRAHIYIHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6B8</accession>
    <name>A8Q6B8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729928.1">
        <property type="nucleotide sequence ID" value="XM_001729876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6B8"/>
    <dbReference type="STRING" id="425265.A8Q6B8"/>
    <dbReference type="GeneID" id="5854235"/>
    <dbReference type="KEGG" id="mgl:MGL_2914"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2914"/>
    <dbReference type="InParanoid" id="A8Q6B8"/>
    <dbReference type="OMA" id="PFADSHY"/>
    <dbReference type="OrthoDB" id="3358698at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="402" mass="45577" checksum="277240699FF83DC4" modified="2008-01-15" version="1">MYVVAPALPAPYKWLQVPLSALHTDRWPGYFAMWPERSNIRSYYVMIPAELKDAFFRNPSMRDASQWSLAVIATATVVTSAMALYYYATYNGFEPANLNLGYYVSLLSPQEFNWTSGFSFSFLDLNEDDEEDHDDDEHIDPELLDGFESANLHHCCNVRLVSADPTSDLCHRPLHMDLLEGKTSRKPLCSGILKSPRASILKQPNQSLCCDLRKPADTPNLRHSRSFQYASSSPRGSWVKEYTISKGGKRLKTSSSSDYLTVPPEQTCPAYERASHPIKNPSRRVSLTEPDWQPFADSHYRARQRTVLAKLVKTYLNKSLDSTTPSTPTEQMADKFFKETLPLVSSSPLRNGSEFWFERFAGSTAAGRKRSDFRRRKRTLADSFNSSVFDKLIHSPNAATPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6J6</accession>
    <name>A8Q6J6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730000.1">
        <property type="nucleotide sequence ID" value="XM_001729948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6J6"/>
    <dbReference type="GeneID" id="5854307"/>
    <dbReference type="KEGG" id="mgl:MGL_2986"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2986"/>
    <dbReference type="InParanoid" id="A8Q6J6"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="252" mass="29214" checksum="503BA9539B4FD22F" modified="2008-01-15" version="1">MLCRVHPFNIPQVRFLSTQRSAALLLVSTSSSASFRCRSHSPQRPHVATRTRLPMSIRTLHCSPSRYVQMEPKKEDKVPQNLAERAAHMWSTIKYLFRFYMNGVKQIWLNRRIVLQIKEDVRRSKRDYTWEEARMVRIHTSDMLKLPLFLLILVTVEELLPLMVIYTPFMLPSTCILPSQRNKIRQRFEVKREKAIQALNKTVPSISVLQTNDNTAKAAVAALSPAALKELVTYVLFIYFVMARMLTLAQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6K7</accession>
    <name>A8Q6K7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UNC-45/Cro1/She4 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730009.1">
        <property type="nucleotide sequence ID" value="XM_001729957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6K7"/>
    <dbReference type="STRING" id="425265.A8Q6K7"/>
    <dbReference type="GeneID" id="5854316"/>
    <dbReference type="KEGG" id="mgl:MGL_2995"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2995"/>
    <dbReference type="InParanoid" id="A8Q6K7"/>
    <dbReference type="OMA" id="ETCAMAH"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="84050" checksum="B31D61135F50DEAC" modified="2008-01-15" version="1">MDQPLHVLLDAACTQRDASRELIDALAAVQNVDVNEAEAWADQLRKEVASPQSDRRIQVMALVGFVCLANAPLAMGLVDASLFDMLASLTNASSNEIETCAMAHLLSEGASHTALRSKLATRPSIEHWLSAHAQSSLTDERVQVCLDLVRIKFAIGTNKRQHALSLPFDTCKLMFETFCAFLESASVYEKQELLSFDPAQVAIADALEGLFYLVSMPALRVALSERTRTLHVLALFLGASTKRKTLFPPRGSSNRDHSNSEDLSPSDDGNINRLSVYDDLDMQTISTGPTHAYVVTSILTTMTAYPPVLSAQDRQIDALRRSALKRANPHQEHGHSADAQEHSDAEHLAPTATAKRVRLLVEAGLLPSLVALAMAPSTASDSHLVPLRRQLQLLFLSLVTEQDAKFRGRLLQQGISRALLSLSQQVYARATSSPTTVEADDLLPFQALAKLSISTNPALMYGLDGTSARAATYLAVLFLAPSSSLLQVFEAALALTNLASMSPAMATLVAHTSYGPSEHKDVANAIVPMFLQFDSVMLRRALMELLCNLVQDESVYAHWSGEGDLDTSRETDIKHNGDEQNGDLVVDDRSPTSAATLDAAESVRSSTLRLHTAHGRLQFLLTLLMVPTDAHETALVKAVAGLVAMLGASPVTCEQLVHMPHSKLRNVADLLESTELSPMDTHELAIRTLTIVSCMTDYAQWLGPSARTDSIRRVLKVTGLVAAVQHYLQRHLTSTARAQQDDVVSVQKHAVTLAVSIFKTMATWNETCAIKVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6V6</accession>
    <name>A8Q6V6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730077.1">
        <property type="nucleotide sequence ID" value="XM_001730025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6V6"/>
    <dbReference type="GeneID" id="5854384"/>
    <dbReference type="KEGG" id="mgl:MGL_3063"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3063"/>
    <dbReference type="InParanoid" id="A8Q6V6"/>
    <dbReference type="OMA" id="NENTECV"/>
    <dbReference type="OrthoDB" id="3364318at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="368" mass="42179" checksum="17D6CA1B11AF8950" modified="2008-01-15" version="1">MSAITGAVSTYQGTNTVAAGVPSRRKFNWENLLCWDAADNGLQALRFSLLLLHLHSRLPSPRSSWNAMMNPTGYVVMRLLTEQQRKSLRRGLLLSTEGVANARRFALLGLWIYTFIKELSLQWHKNKARTHAAGSKQRKEKRAEMSTVEKHTNPTVECCILEDNENTECVEKPAGREPLCITDFVASIGDFVAHVGESFDVAAFLHGSGLFWKAFGMKNIAELPPWLQRRRRGLERVGVFVSLAALIIQIYVAHRRRKGIMREMMHSVKAMRREIKRMDEDRDAARELVPRARLSVEQTYNTLIAERRRLRWLSIEQWCLYGDMAFTLTEAWAPTNDNELLEASTGLFAAILRMLRFWNEIRFGSLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6V9</accession>
    <name>A8Q6V9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730079.1">
        <property type="nucleotide sequence ID" value="XM_001730027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6V9"/>
    <dbReference type="FunCoup" id="A8Q6V9">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6V9"/>
    <dbReference type="GeneID" id="5854386"/>
    <dbReference type="KEGG" id="mgl:MGL_3065"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3065"/>
    <dbReference type="InParanoid" id="A8Q6V9"/>
    <dbReference type="OMA" id="VEMRFHA"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27357" checksum="75ECFF1123EC5018" modified="2008-01-15" version="1">MLFCIPGRAVPRLARTRASGNWHTRALTSTPCRAEQAPSTPTGSAYPFATHVVARSHVVPRSNSVRAPPPDVKHLSRGVMPRVDSQLTTEMDPDERIARLFSRQSPDCILPGSIVMVESYLNNAKTSSTTFSGVLIAVRRSGIATTFVLRAIAHKLGVEMRFHAYSPMIKDIKVLQRADAKKRQPGLTRTRRAKLYYMRRKDDRRVASVANVVKQYRAAALQQKGSSSTAATTDTPAKKSSSSKKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6W3</accession>
    <name>A8Q6W3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein YTP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730081.1">
        <property type="nucleotide sequence ID" value="XM_001730029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6W3"/>
    <dbReference type="STRING" id="425265.A8Q6W3"/>
    <dbReference type="GeneID" id="5854388"/>
    <dbReference type="KEGG" id="mgl:MGL_3067"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3067"/>
    <dbReference type="InParanoid" id="A8Q6W3"/>
    <dbReference type="OMA" id="NVCLAHG"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="728"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="292"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="526"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="95168" checksum="DCAE8D76368F725B" modified="2008-01-15" version="1">MCVAIAGASAAPTSVQARHGGHAEAAVATTTTTSSSSPPPPLGASFQSLSPSSGNITSGIALAAPTAVTRAYSNMQSSSAMATASVSNGPDIHMSLSLKAGTTVAADAPLMDAMHVAHEKHGAHDHSSEFSYDSLTPEQWPTFCTVPTAADKKANADMQDCIVSDELDIPIGADKAGWALRPSPLLNLSNVHAHAHGTDEVMITLNETRLYLRKGAVPLSYVEWDFGSGLGRLSELRRFVSDDAMQIQATWPNRSVVGASGGYWRTLGDIDYPVSWDSLREDIKWRTNEGKQEPARHTGLLVFSSVLFIMACFILLPVLLCLQAARSTLVPLFSLLFLVVLTLSLFFGRLYFALTPELYPPSVLPNLVLSFYALSLACFGVTAAKLLLLLVPLFRGRLRSWNDLHHIMRMLTQGPSPGLHERDEGYRSNLSHSTASTDGTLMEQVPDSPAVHAMDRGESFVMFDQEREPDAPLLDSPASVDSGLYVPMPMHRPWERFVMRHPRVHFTLQVAYTTLSRGLVPLASTIVYVSIAIYTGSCRRGYKNVCLAHGIKGAIFFWYGILTFARYLGAFGDYGWAWNKRPTPENSMHSRASFWRRNMPSAEFVESLVIFLYGISNTWLERLGARPGDPYTVKQIQHISIAVMFWFIGLVGMALESKSVRNMLGYAVVRRHPAATPARANEDETLAQAQPPSYSQSFNPFPSLVIGVTGVAMAAHHQDYLYEVQVHILWGQMLAAFAVLRWLTYFFLWIRPPTSTLPSRPPTEAVASFALCCGGLLFMLSNEEVSFAAMRSDYADAMAMLNLAISIVALVFCWTFCVMMIKAWAFRRDVQAWEPLARPAAQAASSTEPWIKEQPFAASDVSHKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7U5</accession>
    <name>A8Q7U5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729581.1">
        <property type="nucleotide sequence ID" value="XM_001729529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7U5"/>
    <dbReference type="FunCoup" id="A8Q7U5">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7U5"/>
    <dbReference type="GeneID" id="5853887"/>
    <dbReference type="KEGG" id="mgl:MGL_3125"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3125"/>
    <dbReference type="InParanoid" id="A8Q7U5"/>
    <dbReference type="OMA" id="ESFANYE"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160219">
        <property type="term" value="C:cortical endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140506">
        <property type="term" value="F:endoplasmic reticulum-autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160214">
        <property type="term" value="F:endoplasmic reticulum-plasma membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051685">
        <property type="term" value="P:maintenance of ER location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902647">
        <property type="term" value="P:negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000813">
        <property type="entry name" value="Vesicle-associated protein 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="7">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="313" mass="32891" checksum="BF8D3DCE59D74B5B" modified="2008-01-15" version="1">MSVEISPSAQLGFPRPLTQVVKRSLYVTNSNSQPVAFKVKTTAPKQYCVRPNSGRMEPGERVEVQVLLQPLKEEPPIQTKCRDKFLIQSAVITADKETLPIHEFWALQEREKEGVSEHKIRCVYLPPNSEPLPEENEDISSPSAAISHTPYDTSIGAGAGGPGYATEAGAGAGAVGAGVGAGYLAGQPRTSSAHPGAEPPISFAQLNRSEATPMSSQPFATRSGATNMAPASAAMGATTSTTTAVPVATTPRSPQELESEVLRLRAQLASNEKTTTSFNSGRTATAKATSSGVPVHIVAAIAVGVFAITYLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7V5</accession>
    <name>A8Q7V5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729591.1">
        <property type="nucleotide sequence ID" value="XM_001729539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7V5"/>
    <dbReference type="STRING" id="425265.A8Q7V5"/>
    <dbReference type="GeneID" id="5853897"/>
    <dbReference type="KEGG" id="mgl:MGL_3135"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3135"/>
    <dbReference type="InParanoid" id="A8Q7V5"/>
    <dbReference type="OMA" id="DAPIMIR"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="654"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="703" mass="77393" checksum="7793EF041BDE1355" modified="2008-01-15" version="1">MATVSPPAQHSPAGLKPTTSASVSANSHLDEKDTSSVDQLFEHRNVREIEAYASNVLQQARTKQQAVRTLVGDRFRDLLGISRTVVDMHDHLVALRETLEALQRASEHMAEQHANRGARGHVLSSNSHSSEIPHAAILLLIADAPIMIRNALRAGSFLQAAWAMVFATKAWHWLHTSDHTELVSILEPQWTDIQSLRDHVLGCIDTSLQNVSVRTSVVLDTIVAYTLLEQAPINKALEHVHAQRVKAAAICCSDTAPLSDRVSRLVRVVVRTLTLTRTLWARPVLSRILTRLSDGNAFFRLGTTACDLPSSFAPAGAANLYEHMPLAIQTCEAAAGSPILKDDDIHLLTRAFVQRVCTELDAVPNFLANEHDLDVLAQSRHSLKTLCARSNVSEHLGILETHLLTLLDARVRTLLQHTLADVPSAFAAALQRMNEESVPSNALQDLFSAQQDHVHPTHWRTYRAPSIESCLSLVEARIGQTAHSMDVVAAPVHTTCLALIEQLQQVAQADALSIEQMHRLLRVCLAMHTSPVLTKLANKLFFERLADVYMALSRRWARAYVDYVLSLHQEAMPSLLKLAHALHTLGPNPLSPPPLWEEWVLRSQAKGFAHTQDPEPAALTSVPAYLDAMQVDPACVRLMLAPWVPMHSRAPASAVTTLTPSSSSSSQSPSPIQQDDVSHPSPLVPSVTRRRDIARIAPRFSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7X1</accession>
    <name>A8Q7X1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome activator complex subunit 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729604.1">
        <property type="nucleotide sequence ID" value="XM_001729552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7X1"/>
    <dbReference type="STRING" id="425265.A8Q7X1"/>
    <dbReference type="GeneID" id="5853910"/>
    <dbReference type="KEGG" id="mgl:MGL_3148"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3148"/>
    <dbReference type="InParanoid" id="A8Q7X1"/>
    <dbReference type="OMA" id="TTDITHD"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="1">
        <location>
            <begin position="205"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="292" mass="32781" checksum="E99E2764DC84A11A" modified="2008-01-15" version="1">MRRRCKSLQAQLRSARLERKPSAQGASTYDLAASTMALWVCLNLDDHRLGPMSTYVLELVPDLFDAFQLRDNEELSSTAHDVLVQVASFPFSEVQVPALVDCLLRIARSSNSWHSRLDALPFLQIVYFQNLFYLSQSMKEEILHVLHTLLSDPHIEVRDMAAATLSGIVRCSQRAHITDLSQRFAVMAATPLPRRGTPGIEEAITRVHAGVLGASALIAAFPYEVPDWMPALVLDTVAIHSESPVPISTTARRCAADFRRTHQDTWADDQHKFGERVQELHDFTLGRSDYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7Y3</accession>
    <name>A8Q7Y3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipid:diacylglycerol acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729613.1">
        <property type="nucleotide sequence ID" value="XM_001729561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7Y3"/>
    <dbReference type="FunCoup" id="A8Q7Y3">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7Y3"/>
    <dbReference type="GeneID" id="5853919"/>
    <dbReference type="KEGG" id="mgl:MGL_3157"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3157"/>
    <dbReference type="InParanoid" id="A8Q7Y3"/>
    <dbReference type="OMA" id="WRRLWSN"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="48343" checksum="1CD1A2CF72E29898" modified="2008-01-15" version="1">MSNLESRGQRPYKAWWIAGVAVLVAVVSLIVARRAEFSNHIDLLLDSMDEPLNRLKQTGLPYGNIMPPDIREQMEKMLGSARKWYETQDFKVGRELAKKGAEPHHPVVLLPGIVSTGLESWSTSEEQSPFFRKRLWGSTSMIQRALFDKDHWVRNLMLDPATGLDPEGTRVRAAQGLDAASYFAAGYWVWSKIIENLAAVGYDINQLYLASYDWRLSMFNLEERDRFFSRIMSQIEFHTLAYGKKTVLISHSMGGTVALYFLKWVERKRGSSWIDEHLEAFVNLSGTLLGVPKAMPALMTGEMRDTVQAPAMLAYLLERFFSAQERAELFRSWAGSASLIPKGGNAVWGDEHGAPDDLANATKTHGIMMEYAERHSHGNETRPSRKLSVDEVYPWLRMHSDKHFQKMLHSNYSFGIERDPAADPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q860</accession>
    <name>A8Q860_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729665.1">
        <property type="nucleotide sequence ID" value="XM_001729613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q860"/>
    <dbReference type="FunCoup" id="A8Q860">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q860"/>
    <dbReference type="GeneID" id="5853971"/>
    <dbReference type="KEGG" id="mgl:MGL_3209"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3209"/>
    <dbReference type="InParanoid" id="A8Q860"/>
    <dbReference type="OMA" id="LMFWPCA"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="269" mass="29355" checksum="333FF471F475D9CF" modified="2008-01-15" version="1">MWDAKMDAKVERTKTRPIASGRITHGQATIALGLQLAAGLVVLLQLNTYSIILGSLALVPVTLYPLMKRVTNFPQVGMGLAFTWGSMLGWSAVAGACYWPAVLPLYASTVTWGVAYDLIYAQQDKADDKAAGVGSMALLLSDKGTKRALVALSVVWMALLVYAVQAQSPIFPSLTAKDGSTLSLHEWVQLTFATGHPFFAASWLATVAHIYWQIHTLKLNNRMDCWAKFCSNRSVGLIIFTGLAADYLYQWGNSCNTHDKKPELPSEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8B4</accession>
    <name>A8Q8B4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729696.1">
        <property type="nucleotide sequence ID" value="XM_001729644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8B4"/>
    <dbReference type="FunCoup" id="A8Q8B4">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8B4"/>
    <dbReference type="GeneID" id="5854002"/>
    <dbReference type="KEGG" id="mgl:MGL_3240"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3240"/>
    <dbReference type="InParanoid" id="A8Q8B4"/>
    <dbReference type="OMA" id="PGHTRKV"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="149"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="405" mass="44136" checksum="7D87E27EA6AA86B8" modified="2008-01-15" version="1">MLARTPPPLVIEVRDARLPFTSINPKFEEALQSAPSAKERVRISSQTYMSGWAARRLVVYTKRDQIERAWEGPIVRALAKHTHDDHVMFVDTRKKNDVQRVYDWVCARAKLLSKAAAKAGVRQASNSMRHSHLSGAARYTSTPETGVRLLVVGMPNVGKSSLLNALRFVGTGKKSAASTHPHPGHTRKVTGTVRITPSAPSLAQLDMSEGIDMKRLVAREAHRPPSVYVYDTPGIMVPFLGSAEHGGPERALKLAITGCMKQTLFSAEELADYLLFRMNRRYLYARAHGSDALPAYTALMSEPKLTDDNTEFLSCVAGKAPGARQQGGTMNLSVAAEFVISQFQRGVLGSRELDLALNEEDLPPSISLSTSSSTPAAPSMSLDDQVAVRLLAHLASVSQDLQEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8M1</accession>
    <name>A8Q8M1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729751.1">
        <property type="nucleotide sequence ID" value="XM_001729699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8M1"/>
    <dbReference type="GeneID" id="5854057"/>
    <dbReference type="KEGG" id="mgl:MGL_3295"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3295"/>
    <dbReference type="InParanoid" id="A8Q8M1"/>
    <dbReference type="OrthoDB" id="3352205at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="207" mass="23000" checksum="EEF46D2DDBB60CC5" modified="2008-01-15" version="1">MSELFDLLRFDTTTSQRDVTDSAGKHPSLSPSPRGRIAWGESQPSSSPKCTGGSAPLLAPATPAKLPPDNLFLDKENQVLAQDIQKSPSAIRRTRVRRRSRTPLPTPYTYNMCAIVPPVTSSARSDYEPRKPLRKRHKVHGITRIESDLGQDRIPTPKSQNLPPCAMDKKNCEHPQPSSDDSFSRVLDEDFPIDAYALEQIAAQQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8Y7</accession>
    <name>A8Q8Y7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729336.1">
        <property type="nucleotide sequence ID" value="XM_001729284.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8Y7"/>
    <dbReference type="GeneID" id="5853643"/>
    <dbReference type="KEGG" id="mgl:MGL_3371"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3371"/>
    <dbReference type="InParanoid" id="A8Q8Y7"/>
    <dbReference type="OMA" id="WSQMFAE"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1974" mass="213585" checksum="FA7F8ADCB52BFF4E" modified="2008-01-15" version="1">MASVAGDVNVFEPARFESLYDTIHTVTTVPDACVHDWYLNVERNRSPLTNLGRVRAPNEAERRDISKGVIVLGGQSQTLNADFVAQTLLLSDELHVSETYAASLLQEGIAARARWGRSPSEVACLLYYRERLALLACLKELARGTYTLCVGGDLRTGIRMSRLLDDLVSGDVLVQNLLVELDTLRAERERVRTSMQKPPSANARLSDEVQMERLTWISQAEQELGHVAYLLALARRLVPSAIEAVMTFLSKATLPPVESAASVPTTSVYLMTAVLAVFDTVPDEAGEWLAQHSTAPLCTAEALCGDVRCLQALLRSVSQSAWATPGLQHVVQLQLALFLTDALTSHTTLAPALGQSADDVQLLASRAITADGDASALLFLLLRVLSFRRAPEDELDVDEVAPAAMDVEFQEYVLQQVEHLVLGLTTTCFPLLRKLQRAEEDAAISVLRASSRPVTGAGVSAGSLGSSGTGAGGAPLARRYDIEAFFDLVALLCRGRPESGLAFWQGPDRRISRFLLWAVDTRELGQQRAFLGMLASLAEGEQCAAYAHALLEHDAGAPAGSERRLVTWTRLFEWMAHYIEAFQRHAVAVMPPDELVLLRAFLNVLATVVRYSAATRDALFWHKEYMPVDRLFSLYACAVPMDLKAAILRAIGAFAVQSGTSTSARIVTVLWERLNLSGAVRSVRGEPPRALYELENVECVHGRFPSTHALVDLLSAIVPHVAPASQADTLVAYMRDASLPWWHSGRNSTTASSTTASTSHGSGNSMSTSMYVAYVLDHVLLPASNRTYARPAERWAISASCLEFAEKCLATLPVAPVDTAHPGFDVLRRLLSGTPLLRELFFFVHPDPSCAGYEVINMNRAQTPDFSRAVRAALRILLRMLEVQNDVLHNVPSINDHAAVKDRALFLALDVHLLQAHQVVVQIALYILCVDTEIAWLAVRLLGALARTSTFQATDAFGPLRARTSRNRLAGLLDMAGETARVTSGVLAWLEADTGMDADSDNLNYDADVNGNYHAPGTTAHMDMSSSLSDADGVASLNDTATGILPAKIQKELLDLFLEQLVPDAPAPNVAHLLLGFDMDASDPDRLVHESRDAILLTLVQRVTPPCTWPPTLAERCYAVLQRACVHPYTSASMLRFLRTHDFVATQLRSLPLVPLSVTSSSSATGPSFGTLMYASGETVSTRTEWALALLRTHAHILSLVALELHTLAAHGQLQRAVPLMTLLLGEPVMHGTGGGSGRWRPLLEATHVTWENAAEDSVSEPKWVAARLAPALVPDTASAARVYDIHEVAALLLEERGTQEHTVWFEQARRILLWAAAQNTRRAFAYARREAFIAWRQVMEVLVGQALTTVVRADVRVPILLDCANALLPRLQDQDDALVPSIAASTILSLLHAVREHEDVPAERLVLIVRAILDVLSFGTQASTRCDLYLSLVCAQQLVCSRSSVSHGGRAAAAHRVYSLFATHAAHLVNVLARDALDGSDVAQTVSLTTLSHLVAWDGASSTASSPSPASASVLPALHIGEKLASAGFLKSLALRIHELDVPLQATLTPDPPSLNALYVYEALLSVLGRLARSKASLLLEARIVDVLARVDFPSLRPEHTLDDMDGFLPPVAERYASLLMPLLQLLVTLLMSVPQARESVHAVLVAHQDAFLAALHAATHSSAGTGDVEQAALLVQILTFMTPPLLPTPPPFHAACLALAATYLVPNAHEALKPLTLAEREDASIFAPTYNGLVQTAPDARLTLFDASARRVVDRLARALVQYMELASSHGEARAILVPSMHVARVSDHASSAARIVAAPSLGVAIAALGEQCASVALALSSLDRVNALLRDPESVHADEWTDMAQDAGLLSLSASSALTMQCRAACEKALDCVSKDLTATVLAKLDMIERWLVMLVRHLDLFMRIGGASRASFDAAALRSSANAALLPILDDQLAYLTVPSHLVPSADEHVTFLHISARRVAERLLETSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9E6</accession>
    <name>A8Q9E6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 1 transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729432.1">
        <property type="nucleotide sequence ID" value="XM_001729380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9E6"/>
    <dbReference type="FunCoup" id="A8Q9E6">
        <property type="interactions" value="516"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9E6"/>
    <dbReference type="GeneID" id="5853739"/>
    <dbReference type="KEGG" id="mgl:MGL_3467"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3467"/>
    <dbReference type="InParanoid" id="A8Q9E6"/>
    <dbReference type="OMA" id="IHANIQL"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="62338" checksum="750923E39A0078E2" modified="2008-01-15" version="1">MTSNAKNMVPTSGKGLVLLRLCNELLRRLSKTHPQHTMLAGRIFLLLSSTFAISERSGVNLKGEFDTNQTIDIEAVNEHCEPPSETKPEILIHHPQFYVLFWSLQRYFTNPTLLFSESDAPGAKAAEALGLQERQASTPMHTFQTGIQCVLDVMRWLNKKSDSPPKTKRARFETSASSPTYPRYRCTQTLFGYELHNLAFQQQYLVQCLITFQYLLGQTSATHEQSKEWKNKLLVPMHTLKQEEEQWLRKTWRQIQTVLRESSQEGRVFLDAVLMLLRRESSWIRWKAASAPSFHKDALNPDTLQAWSDKIRTTFAQQEPWFPHALGTPELSRLWEDGFHVAEPSEMHVNDEEGHDKTIRTDGWEELKFPRAPPSLRSLCRAIEHCTDPDQAQSLSWRALRCASLEHLHVFARMRALDDIPSLVQAIDDEHNDIPYEVSIIGEEPSTEDDDNEHQHADVDAIDVDDSAEQIAHFEHKATSTIIHTLTLRIRQSLLCPAFVHLKLGANPHRRPRLLITQPIHANIQLRRGRASITKSRGHDPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9P4</accession>
    <name>A8Q9P4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_3527</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729492.1">
        <property type="nucleotide sequence ID" value="XM_001729440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9P4"/>
    <dbReference type="FunCoup" id="A8Q9P4">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9P4"/>
    <dbReference type="GeneID" id="5853799"/>
    <dbReference type="KEGG" id="mgl:MGL_3527"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3527"/>
    <dbReference type="InParanoid" id="A8Q9P4"/>
    <dbReference type="OMA" id="RCPNYSN"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000270">
        <property type="entry name" value="Non-structural maintenance of chromosomes element 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="16">
        <location>
            <begin position="157"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP42278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="226" mass="25174" checksum="FE7BC283A4F01A35" modified="2008-01-15" version="1">MYRHLAEHLGHEDKWDEDLEAMQHSLQPLGFEVRSCHDERSGIVFLVLINTKSDALAQVATPYTASELQYIKTLIHAIFHANDNQYALSSTQALQLAMQSQPVPLTKHAASQLLENLERRGWLHLSRTIGAYSLTLRALHELDTYIRTELEDCVLECLTCYAIVTQGERCSTPACRGAVHTSCVDAYRAGHATCTVCGQAWQTVPVGVISTSTRDETTPIPEEPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA25</accession>
    <name>A8QA25_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729120.1">
        <property type="nucleotide sequence ID" value="XM_001729068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA25"/>
    <dbReference type="STRING" id="425265.A8QA25"/>
    <dbReference type="GeneID" id="5853426"/>
    <dbReference type="KEGG" id="mgl:MGL_3587"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3587"/>
    <dbReference type="InParanoid" id="A8QA25"/>
    <dbReference type="OrthoDB" id="3362263at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="739" mass="80924" checksum="85181E117DD9DB8E" modified="2008-01-15" version="1">MGVVEAPPPTVPMSISSQPLMPALQYTVPFKLSSKRRFKAKSVPASDSSPSVPRNTVSSPIPPTPLPKSPVPRQPKPPKNSTYRKSVPAPTVADENEELDLMAKGSARPTVLASSSSPSFPTRSPVQAAVEAPVHVSARPPAAQSATLVGPSTSSYGRLQPALAPELCGPVQSVEGRNVWLDVSDNDAANTSHLSMLGAVTDRSDLFNFETYFEASLQRIREEMYLPSTSSAQIAIKPPAKTHRNLVARHGDPDLFHNAPPINARTFGSPVTALDEFSYVLDDDGLVMRASQTDSYTTMQPSLSTSKPIPELPPVDPYLPEEHEVMGDSQPISSEARDRRWTYDGTYSPILSDESMPSDVRLPLEFVTKPNSVLSRGRPVKKTQQSIFYSSLPEHRRHRKRRLESDLPPFKMWNFEEADVDSDAFSQSMSQSSPRGTQSKTASPPRPAPPPPPAPKATLLGDYAAVTPKMPTQNLYPSSPNSKYTPHSAYNKLFETPPPDQYAKAHLQRPARPRRHHENHETSYNEQQSRQTEQEPRDQCDAQTQQAQLNTPTSQNFPPQREVEAEAASFDAGPRKKRGKEAAESKFSTWFRRKAPHVSKPSSSAPTQNQVPQVSSPPPSDRPPSPRTSTSTNNTMKYGRRKAPPGFEPSQPGKYHLAGTVSLPTLNVARTPEQRARNETGLPETEPALIQSLLAAPSSSTVRARAGIIKSIPFVEEAAPPTGQVLVAEERKVLVRPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA43</accession>
    <name>A8QA43_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729135.1">
        <property type="nucleotide sequence ID" value="XM_001729083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA43"/>
    <dbReference type="FunCoup" id="A8QA43">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA43"/>
    <dbReference type="GeneID" id="5853441"/>
    <dbReference type="KEGG" id="mgl:MGL_3602"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3602"/>
    <dbReference type="InParanoid" id="A8QA43"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="120"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="339" mass="38388" checksum="9FD4DD52874395B2" modified="2008-01-15" version="1">MKGVKPNTVRRSSRLSLKEKRIGPPLEAEFEPSAHKKAKVEPRVIDSELPLLPEDKVKLCTTLNQPKLSFSIQEARQHLCSIDSRFASLFAQLDLKVYDELRSGKVKELNLFRVLTTSILGQQISWLAARSIMYKFCRLFAPDLPLQPNLDAVNKDELPFPTPLQVLKATDDELRRAGLSTAKIKYVRDVARRFSDGRLDVRKIIHMNPEACITELTQVKGVGRWTAEMLLMFALRSPDILPVGDLGVQRGIVKFYLSNSAGPKISERKRKDDYVHHDESKAPGFLPSNSLSLEQLVSRSQGNKTKKHMYLDPEEMSVLAAPWAPYRSVACMFMWSIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA60</accession>
    <name>A8QA60_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729152.1">
        <property type="nucleotide sequence ID" value="XM_001729100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA60"/>
    <dbReference type="FunCoup" id="A8QA60">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA60"/>
    <dbReference type="GeneID" id="5853458"/>
    <dbReference type="KEGG" id="mgl:MGL_3619"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3619"/>
    <dbReference type="InParanoid" id="A8QA60"/>
    <dbReference type="OMA" id="QVHEENA"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="305"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="552" mass="62002" checksum="E12177A30EB6657C" modified="2008-01-15" version="1">MTDTHSTLTRATTASRKSTIASRNASLIKKNTGPLELRPSDILIERFTGWKNIVKMLISYFEGIADIEYNTAKEMNKLGGVIQVPFREGNQFLGEDGLQDIFYSIREKTRTIADHHSNLAKTVEGSIVQHLEKLRAEIKAHVRNVQQDTGKLANTVAREREISTKMISDLARSITLLKNTPMSVSPREDPFTANQAVSMQLQRQVNEENALQKSIIIMQQNSAHFEEAIVRSIQSAWQTFDEWSGRMSAQVQDTWLGLGVHMRSLEPNAEWIAFASRSDHLLDPDTPLRNPETIDYPGKEDPSVIPVHQGMLERKKRFTNAYKESFYVLTPAGYLHEHASSDPVRHPVPELSLFLPECTLGAPSTAAASTHKFHIEGRTGQQSNMFGTNVAYTFRARSHDEMMEWWNDIKQLSKVYLTTSEQMDRSGPVPAAVRAAGYRDEEEEEEEEEEEEEEEEDDEEYDEGEYIQTVPAASVPHHHYGAAPPIPSTVTSAAPVTVLDDMRRREQIPSYSAPTRDSGIEIGSNGYAIEKKAQPSEPLAREGAEEVAHISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA91</accession>
    <name>A8QA91_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729183.1">
        <property type="nucleotide sequence ID" value="XM_001729131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA91"/>
    <dbReference type="FunCoup" id="A8QA91">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA91"/>
    <dbReference type="GeneID" id="5853489"/>
    <dbReference type="KEGG" id="mgl:MGL_3650"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3650"/>
    <dbReference type="InParanoid" id="A8QA91"/>
    <dbReference type="OMA" id="RTHEKYI"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="204"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="39545" checksum="9C372CF9EE338363" modified="2008-01-15" version="1">MALSSYFEASETGITDAQEESVGTASHVSPAQSTSSGPRTLSGASVSDDSPWPSKAPTSARRTQKPRSGGIMTFNDLRSEQKPRDNNNEPVNLFTGGERSGLNVETPEHRLGGTGRNLVDDILSKAASSSHPPVSDDPAAVNLGQGHSDAKRSTAFSGTGYSIGGATVGQGNEKHDHEDGISTHVPDPHMPGSVDLDEPGDEEPAVRHLTFWQDGFSIEDGPLLRYDDPGNQSTLQAINSGRAPLSLLNVRFGQPVELLVARRTHEKYIPPPPPPSKPFMGQGNRLGAPSASGLGDSAHRLTADGTVTKATNKHAAALDASRESSAKSASSSSTDVDLSKPTVQIQVRLSDGQCLILRLNESHTISDLRREIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA98</accession>
    <name>A8QA98_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3657</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729190.1">
        <property type="nucleotide sequence ID" value="XM_001729138.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA98"/>
    <dbReference type="GeneID" id="5853496"/>
    <dbReference type="KEGG" id="mgl:MGL_3657"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3657"/>
    <dbReference type="InParanoid" id="A8QA98"/>
    <dbReference type="OMA" id="KNPRQGA"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001354">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="898"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1029"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1126"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1156"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="264"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="590"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="903"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1216"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1485" mass="164588" checksum="5D6B839750E881BF" modified="2008-01-15" version="1">MQWVYLLLSVIGILVTLTYSPESKTLFLPFLLQAIWLYSASDPSQVSLEIRWYTICTVFSITLVYVLCELLRCTFGYEMSTGHWISVALLAIICMLSGTQPGSPSCEAHGGKVIEVAHRERDPVIDSGRDEEDSPGPMNMAPSETMDNSVLGALFFTHVFSLIRCERRRGMLGSLDVPVLGAHLHAEVLGHQVERAFGNDAHSTQPRAIELEGFDDQDGVEDENAPLLPQREPTSQSSDEPALWSPIALRLLGALVRANSTQFFVICILTMIAVLAYYGPAFFANRIFHVLEADQDLSLSPYDTLQHAMPWVLGLFLTVIASSTLQGALWSRLEGSLAIRLSTQLSMLLFNKTLNRQHVADTSSEGKGQQQVLALQLVDLERIVGMSFHLFAGITTPLELCVGGYFAYRVLGISAIVGLGTSVLLMPVIGLLSRHFRLANEKLMASRDKRMALLNECFLGIRMIKSQAWERVYKTKVEDTRSSELGQQLRTYVYEAMLSTVLEVNPLLVTLVAFTFYTQVLKHTLTPAIAFTSLAIFTELRWTLVLLPRAITSFLQTLVSARRVGEFLVSTEVTPSPYSNFFVRPSDCTLRMEHATVSWPTMPGQSSFRLSDINLVFSPGKTLICGRVGAGKTLLLHALLHEVEVQKGEVICPRSPRQGVPYNAHSRAEALRALGTPDWLRSDLVAYAPQVPFLMHTTIRDNVLFGLPLGDGKLYQAVLEACGLAPDLKYLEQGDLTPVGENGMELSGGQKARVSLARAVYSRAKILLLDDIFSAVDAHTSKHLLERLLNGPLLKGRTVLLVSHNVEQVAKSMDQVVYLDGGRVDFAGSPKEFLSSKQYMGWQESDNQEEPKHEDPAFFAADAPRLSTSAVKRNIERREKGGIASHVWGAYIQASSGWALCMITVLLFALTNLWGLVTNLWLRDWSASDGRGHTSSWWLIRYAGLLLVGIMFGVLRWIGIYTMSLRASRELFEQLIRRTLHAPLQFFDSMSRGRLLNRFGQDLEVLDSKFATAIADVAIRVTQLLATSIALFIVGGIGFVIALFVLLPVYGAVAQMYIAVARDLQRLRSTSRSLVASSFTHAVHGVQVIRAFGAQEHFECEMMGLLDNTNRFVWWAAQGGRWVSQMYNLTSSVLMLVACVIMLLQPHTPAATIDFSLTFLIDLNFVLLILMRMYTQLQVNAVAVERVFEYAASIEQEAARIKEPRPPSEWPSKGDVQVRDLVLRYAPDAPDVVKRISFSVPSGSKLAIVGPTGSGKSSLFNAFLRLLEPQSGSIVIDGWNIGRIGLEDLRSRLYLVPQDPVILSGTLRSVLDVLGEFDDAKLLACLEAVHLVTDDNSAGKSPFSNLDMPIAENGSNLSQGQRQLLCVARALLHKSRIVLFDEASSCIDYTTDMRITETVHQVFDKCTVITIAHRLRTVIGYDKVMYMDHGKIMELDEPAKLLDDKSSHFYRLCKQTGPAEFQFLVEAAKQAASKRQAPPTIAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAC3</accession>
    <name>A8QAC3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729215.1">
        <property type="nucleotide sequence ID" value="XM_001729163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAC3"/>
    <dbReference type="STRING" id="425265.A8QAC3"/>
    <dbReference type="GeneID" id="5853521"/>
    <dbReference type="KEGG" id="mgl:MGL_3682"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3682"/>
    <dbReference type="InParanoid" id="A8QAC3"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="116" mass="12800" checksum="609308202BB67290" modified="2008-01-15" version="1">MLAPYVRSYSIPTLPVTCTGALDGSVQVFFTELEGVQEPTSTTSAWTYQPARRKARPRSRRSKPLGTSSEPLSLTEEAFWTLPPAKAEYGPEVLTTPIPISPKLHGTDERIPQIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAJ2</accession>
    <name>A8QAJ2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prenylcysteine lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729284.1">
        <property type="nucleotide sequence ID" value="XM_001729232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAJ2"/>
    <dbReference type="GeneID" id="5853590"/>
    <dbReference type="KEGG" id="mgl:MGL_3751"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3751"/>
    <dbReference type="InParanoid" id="A8QAJ2"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728042" description="Prenylcysteine lyase domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23490" checksum="FDEBF9ACE68B8A34" modified="2008-01-15" version="1">MKIPVTAALATILLVPLLGISFAFAIPTVYQTPFHYNENPENTQFSSNEPAYNVSECPSPEARPVIRVAVVGAGISGTSAAYLLSKAQKHLDKVNAYGIPGCKNVTWPERVLVTVYERSEKIGGRIQSIHPLDDPKYPPIESGASIFSEVNAHLVQASSSLHLERTPREMIPNGGYGLWNGEEMLIDNFGGSKWDQLRLYWRYGFSPQTTLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAK2</accession>
    <name>A8QAK2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729294.1">
        <property type="nucleotide sequence ID" value="XM_001729242.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAK2"/>
    <dbReference type="GeneID" id="5853600"/>
    <dbReference type="KEGG" id="mgl:MGL_3761"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3761"/>
    <dbReference type="InParanoid" id="A8QAK2"/>
    <dbReference type="OMA" id="CEYTILP"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="188"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="683"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="777"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="729"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="820"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1534" mass="170889" checksum="733A9966B7FE100C" modified="2008-01-15" version="1">MQDPLERIAPNKAEEQRDQNTKRMPHEVSTSTQNVNEERRARGPNGAELKANNRNKNAEMAAAIDSNATKAPATRSRHSRSYIAAQQANAAKREREEWDRTRGAGSNVLLRYEEQSARQASATDENRSPASSSSAAGPGSDMHQARRTAEYTAADVVPPIEEILQRPTQPVEVTGMDRLLDWGLCEYTILPKTLGRGRFSTVYLAMKNGERYAIKHTPLFPHHELVATRLLREPTLLAEIPPHPNLVSVIETIRTPGHFYLVEEFLDGYVTLEALIGRMNINTPTSSAHKLPHDAAEKVFEQLVLALYAIHKPLRVCHRDVKPENVLVHPETLQLKLLDFGLATHFSRSHAKLTTCCGSPAFHCPEIVTALSKPLGSVSYWGPEVDAWTCGVTLLRCLSGIRYPLGTSHTSPASMGARAKRVLQTLPPSQLLNDVAALLDLNPERRMRYFEQLAERIQSKPEHQHSRHRRELKCTSFVPAPPQHAMVLPLVLTNEAADLASSHDERLPIGPDFSMITLLNTSLQPSRRVLSFIKYCLRCAGILYHTLAVAGKYDEPGTMRMPTKAVPKSEAVRACAFQCVIELLQDEEPGTLAQVMQTIKSLFGQRTTTEELVKLPARAVNPRAKDMSEPPSSGPSGKQGPLRMLVFYMVVAFPSGTETPMFQDLEPPAPEVIAAALQNRLAPITKQTSASPRHSIRRQSAEEPSLYIDTRVERLPPAQIVSPSPPARARSHTHSRASSRSRSKAPSARSNAVQVYVSDARALPYVRGALSNGGVLKQESLRRESGKSDSSISRHRHTAVNASDRHPEWQTKDVKTLPTSPASLSSRAKSSSATPEQRSVEIMGPHELDTSLNAIESTCRSLLVRRMTPGRSDTNNEHAHQLYMLVHRLYRQLQVSLQSQHKDALQRQMAECNFRALDVLGPTLALVGADDAPTSAADIDVPETTNIGSVALAVLELFSSCSSAKEMCLGFQEQMERLSLAWRSREDAPNETDIDAVTMLARDAPMLIQAVLGQLQCLADVLPAIQTRRPRPLLDSVLGLVYPTLYRDVLCEALDMVRERDTHEELATQAAVVLCELMVSLLSHARSVDEAERPDIACVLGDALYELVRFLPLSTSVETLTNDKAAASTSLPVSDHSVQRTEAVPLLAQPTLNLDTVSRRVTVWNIVRKTYEQLDADIGTRALGMPDLSRTAVAPLPHPHAQRNFVLFVHQLAYEALMVRVKGRVRDRFRAATQRSSTMPSPQRWSAELARELCHRFASVLPSTLVPGLSPLDVPSPPRTMACMQDWFLCDAIVTFLRWIVEALPSETRPRVVLDDDSITYSARALAMVATHCTHARLRQWAFEVVTRFVRDASSDDVTLRLVREFMSPTTPPPLRGASVHLVRDIVSRRLERLEKAQVQTDGLVSDGRLWRIWNDGLFVMPKARPNPPTDATTRSDTKMTELATYLHQYQTYLQECCSLFYYVAVRDAAHNYTGFRDEREYTRLYERFVQPLKQWTLAWQSYIAQHIPDDVTATNLALLAMAIARIEGSQLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAP7</accession>
    <name>A8QAP7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729017.1">
        <property type="nucleotide sequence ID" value="XM_001728965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAP7"/>
    <dbReference type="STRING" id="425265.A8QAP7"/>
    <dbReference type="GeneID" id="5853324"/>
    <dbReference type="KEGG" id="mgl:MGL_3805"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3805"/>
    <dbReference type="InParanoid" id="A8QAP7"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42245" checksum="886B134721BB0847" modified="2008-01-15" version="1">MLQGLDPLARQRIMRRHRQKREGVPDWIPTGKNKHTFSSNTKPFTTFEPSPSDTSVSPSNSGENSSKASATPTTLRGSNAHATATSTIPNASSTARLNGSSNAHADDGKPISNGAIAGIVVGGFFGLLFLCLIAYWLLRKCRPRSTKAVARAKNSTPAHQKQQPQPQSPPQHPPFVTHEYYGSQPVSYEPNALYNVEYQYDEFGHPVYISDHQQAQREPRLAEQSQGHQGQQAAAAVAGIHSGNKNNMRVDGSQGKTMTTKKHSPRRRPVPDISTEMDNSNLEHDTSFPSSNDSSEFKDAPEDSMQETVPVRHQHHERHRPREHRERKQHQKHTRRAHYYEEAFEEDEISPSRRTRMRYAQAQAKRSDIDPALVAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB27</accession>
    <name>A8QB27_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729087.1">
        <property type="nucleotide sequence ID" value="XM_001729035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB27"/>
    <dbReference type="STRING" id="425265.A8QB27"/>
    <dbReference type="GeneID" id="5853394"/>
    <dbReference type="KEGG" id="mgl:MGL_3875"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3875"/>
    <dbReference type="InParanoid" id="A8QB27"/>
    <dbReference type="OMA" id="QIHERSA"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14280" checksum="7B56B3A1E9223E3C" modified="2008-01-15" version="1">MPKLVMKLIFMLVPSQSPFFVRPILNMIGSQVNGRLVDPDLKAMIKLTSDTLTKESGDGRAWFAGGDKDGNPTAADYQMLFPIEAITSGRMDPAMVPEPLKNWIDMVHKRPAYIRAYEKGGAYDYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB38</accession>
    <name>A8QB38_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cryptochrome/DNA photolyase FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729092.1">
        <property type="nucleotide sequence ID" value="XM_001729040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB38"/>
    <dbReference type="STRING" id="425265.A8QB38"/>
    <dbReference type="GeneID" id="5853399"/>
    <dbReference type="KEGG" id="mgl:MGL_3880"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3880"/>
    <dbReference type="InParanoid" id="A8QB38"/>
    <dbReference type="OMA" id="WDIYDES"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptochrome/DNA photolyase FAD-binding" evidence="8">
        <location>
            <begin position="105"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="232"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="400" mass="46127" checksum="9954B30EC973E88C" modified="2008-01-15" version="1">MFHTDHYAQCLDWSSPESEHNPTWASEFPWIPGSETAHHILTEFLKTKVSRYSESRDIPFESGTSQLSPYLAHGEISPHRVLHALREVRLNRDTPKPAIESSKTFERELIWREFNYHLLYHQPDLATQNHNEQWNLFTWSQMATESQLTEFSRTGELPPSTDEQNALNTAAAYDCWRAGHTGFPIVDAGMRQLWKIGWMHNRVRMITASLLIKNLRIHWRLGEEWFWNTLVDADPASNPGNWQWVAGTGADAAPFFRIFNPARQADRFDQKCAYVRTWVPELKTKTTQEVAAMYEASPRKAAKEQDEDFLALTNPSLTSQWIHSSPNSGSTSNSVKYATPFSHAFSQRYVAVPETNYHNLIVDFKKSRDLALSCYQTIRKNSESSLSSDTTPRKKFKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB76</accession>
    <name>A8QB76_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728894.1">
        <property type="nucleotide sequence ID" value="XM_001728842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB76"/>
    <dbReference type="GeneID" id="5853210"/>
    <dbReference type="KEGG" id="mgl:MGL_3888"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3888"/>
    <dbReference type="InParanoid" id="A8QB76"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="457" mass="49070" checksum="AA590C4571043384" modified="2008-01-15" version="1">MADASQITALATEAGRIAIGQVSGRISLWDLDGQTFTDVSVTLSDASADSVDANGMRDSLHSVQKLVFCAESILSLHGDGSMYAWPSMLGDSMSRARVLVESQNELAPSWTAASLSTNEPGTWIGASSSRGHLAIYHVSKDLRVVQMYTVQNPANVPIRCAVLVPQCSNGQNRQDLSIRPTPPRNPGILSPSATSATPKTVTAPTATSSSSSSCLASPAHRHNLAAGDEKGILHVWKLLDKGSSSIDMDLALDMPFDGPVRAMQIMPGTTLLLVQTSNRVWLIEWLDTRRLPLQPLDSIPNPRGSVDIVPMPRVEWLLGICRAGEASSRWEIWRARIPSSLVQHVTPSTTAAVTALASTSNPAFKSASSPESTTVSALTASSSTSGNFFQVERIPIDIESLIRTAVRNSVVQGLHPPSRLPLLTTRIDRMFRVGNTWQWIIPFGSTILAFSAEQGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCG7</accession>
    <name>A8QCG7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3">5.1.99.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_4007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728840.1">
        <property type="nucleotide sequence ID" value="XM_001728788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCG7"/>
    <dbReference type="FunCoup" id="A8QCG7">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCG7"/>
    <dbReference type="GeneID" id="5853146"/>
    <dbReference type="KEGG" id="mgl:MGL_4007"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4007"/>
    <dbReference type="InParanoid" id="A8QCG7"/>
    <dbReference type="OMA" id="SMFRGRY"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="230" mass="25044" checksum="0C226C48969101C5" modified="2008-01-15" version="1">MSPAGGFSIDQLMELAGLSCAEAVYRSYPPHAGYRRVLVACGPGNQGGDGLVAARHLKHFGYTPVIWYPKRKDAPLFHGLVQQLQNLNIEFSEVDQLPGTLLQDSQVVLDAIFGFSFHGEPREPFRSALEHLVQAQRNPSTKVPVVSVDIPSSWNVDAGPQESELAKSFMPDVLISLTAPKSGARFFSGAKHWLGGRFVDSGLDAKYDLRLPSYPATSQVVDITGARPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCN3</accession>
    <name>A8QCN3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_4028</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728861.1">
        <property type="nucleotide sequence ID" value="XM_001728809.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8QCN3">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCN3"/>
    <dbReference type="GeneID" id="5853167"/>
    <dbReference type="KEGG" id="mgl:MGL_4028"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4028"/>
    <dbReference type="InParanoid" id="A8QCN3"/>
    <dbReference type="OMA" id="ATNTCRI"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="543"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="840"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1396" mass="156887" checksum="75E691F23E922FAB" modified="2008-01-15" version="1">MPYELTSVEREALDNVPNVFTTQEVLETDGAGYLIRPWMTFNLYDRISTRPFLTDMEKVWISYQLIYAMHASHAQNVAHGDLKCENVLITSSLTAYVTDFASSFKPTYLPLDDPTDFSLFFDSSGRRICHIAPERFYESVTELPAGPISSRTQPKDIENMSEVLTYEPYLEILGLGRPNGRITEAMDVFSLGCVLAELWRDGSPLFTLSQMYRYRARQYDINPLLQSVSHSGMRDVITSMLALDPEKRPTFKHLLRDAHGILFPESFSVCLHLYLVDLQRPSPDIPLPQPPNENQGDQLRTRHFLEPDDRIEKLYEDWATLQKFFGAIPSIEGDQVQLHVSIPNVSLPHQVGRPPSLSDNEALLVLNVILANIRHCHRPSSKCHALELVVILVWGWLSDETRLDRVLPYLIALLTDKHPRVRAMALHGISVVFECIHVISAVNKRILHEFVWPHVVPLSHDPSVHVRCTLVSCLARISTNAMRLWFTSPTESFDTDVLSLQEFVRDQMYTLVCDSSSTVKCVLLSHATSLCTLLNTDCVKSVLLTHMLTYLNDENTDLRMAFFDAVVPIARLLESDTIEKCIYPFLLQALGDDDVRVQVQVLRAIQQLIPLFQPFMPWKLLDRTISLLYHPNPWVREASIGVVTEVSSLISNSDRWLRLYARIRPYLRCDITSITPISLLDHLVSPLSSHALQQCVSTMKTKKDATFLDLWYSQVRRVEIKDGVSSTNMRKEMDDLVRPPSSSHWMTLAVRIEEPHPNILSRLDGWGIPSGDIPKLAALWWYVEILATKNTRQQAKPAPPNMKLSGVRQRTVFFTPRIAYQALPSSVSIRTAQKRIQDLACVSSSQQDSREPQEQNSESELESKPQFEILNELSRKSEPSHFSYRSHGRTASKASSDATSLSECSIKWPVFTNPSTAQASTTLIHAHAERARAESAKEESDQAPGMLVVENTYEGMDPYIHAHLKAAYQQLQEQSRTVVSQHTPCISHVQTSPAGSHRPHGALVACLTEHTAAITSLSVALDQMFFVSGSDDGTVKVWDTSRLEKNVNSRSRLTYATHQSPITSVLVLSGTHCVISASKNGSLHVWGVGVQTGGSLPRYMRPHILGKHTLSENEYVRCLAQWTSGVDPVVVLGTSRGRIILWDVRHMNPLLTMSHPAEHGPVETLVLDPQRNWICTGTSCGVIGLWDVRFELCIRAWTVKSQSKILSCTLHPCYSRRILVAWSTHEPCCFATLDLDTGLVTDMFNVIDLEHAQVPDVAENLFSPCQDATHHFGAETTLPNLNGTHVLLASVYGYTSTAQKDTSLKGWILSAGSDRVVRFWDLGQADRCVAFGVDVHGEFTYVLILYLHILLQHVEGRRDSNYAVQPRRATFRPCTQALAVTYSSADENQTGCGCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCY5</accession>
    <name>A8QCY5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_4057</name>
        <name evidence="5" type="ORF">MGL_4271</name>
        <name evidence="4" type="ORF">MGL_4277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
            <strain evidence="6">CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000039">
        <property type="protein sequence ID" value="EDP41370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AAYY01000035">
        <property type="protein sequence ID" value="EDP41378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728584.1">
        <property type="nucleotide sequence ID" value="XM_001728532.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728592.1">
        <property type="nucleotide sequence ID" value="XM_001728540.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728722.1">
        <property type="nucleotide sequence ID" value="XM_001728670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCY5"/>
    <dbReference type="GeneID" id="5852892"/>
    <dbReference type="GeneID" id="5852899"/>
    <dbReference type="GeneID" id="5853043"/>
    <dbReference type="KEGG" id="mgl:MGL_4057"/>
    <dbReference type="KEGG" id="mgl:MGL_4271"/>
    <dbReference type="KEGG" id="mgl:MGL_4277"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4057"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4271"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4277"/>
    <dbReference type="InParanoid" id="A8QCY5"/>
    <dbReference type="OrthoDB" id="3355236at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007636928" description="Invertebrate defensins family profile domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="3">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="142" mass="14548" checksum="DC8EB846FD8A79E6" modified="2008-01-15" version="1">MRVAIVLSLVAMLFSVVSASSLCFGRPSFLGSTCAAECSVRGHHGGSYSNGQCCCGASTKRGEETHTQEEDLKSAEDFFGGKLLMSDDDSLEVHNGPSVSRVSCSACNIGGFNGGGLCCKASCATVGKPGGYCNGNNVCVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD08</accession>
    <name>A8QD08_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_4076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728741.1">
        <property type="nucleotide sequence ID" value="XM_001728689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD08"/>
    <dbReference type="FunCoup" id="A8QD08">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD08"/>
    <dbReference type="GeneID" id="5853102"/>
    <dbReference type="KEGG" id="mgl:MGL_4076"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4076"/>
    <dbReference type="InParanoid" id="A8QD08"/>
    <dbReference type="OMA" id="IVRFGCE"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="324" mass="36003" checksum="9D89946AFFF2E7ED" modified="2008-01-15" version="1">MSNALESLKQYTTVVSDSGDFESISAYKPQDATTNPSLILAAVKEEKYAKMVAPAVEYAKSKGGSRDEMIEHATDRLLVSFGEEILKIIPGRVSTEVDARLSFDKQATIDKAIKLIQLYESVGVSKERVLIKIASTWEGIQAARELESKHGIHCNLTLLFSFCQAVACAEANVTLISPFVGRILDWFKKNKPDADYSGANDPGVKSVQLIYNYYKQHGYNTIVMGASFRNTSEIVELAGVDFLTIAPKLLDELKNSQTKLERKLSKENAQAAKPIEKHSYIDNESAFRWAQLEDAMGFDKLHEGIRKFADDAVTLKEIIGKQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDQ2</accession>
    <name>A8QDQ2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000023">
        <property type="protein sequence ID" value="EDP41414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728628.1">
        <property type="nucleotide sequence ID" value="XM_001728576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDQ2"/>
    <dbReference type="FunCoup" id="A8QDQ2">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDQ2"/>
    <dbReference type="GeneID" id="5852943"/>
    <dbReference type="KEGG" id="mgl:MGL_4227"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4227"/>
    <dbReference type="InParanoid" id="A8QDQ2"/>
    <dbReference type="OMA" id="DMNPFKL"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="314" mass="33913" checksum="72A25603BFC36D5B" modified="2008-01-15" version="1">MGANRASKENWFSRLNELIDTNTSIFVVNVDNVSSQQMHQIRQALRGQATVLMGKNTMVRRALRQVISERPEFERLMPHVRGNVGFVFTSADLKEVRDKVIENRVAAPARAGAYSPVDIFVPAGNTGMEPGKTSFFQALGVPTKIARGTIEIVSDVKVVEAGNRVSPSESALLNLLNISPFTYGMTVVQIFDNGNVFSSSVLDVTEEELVGRFTQAVQQIASISLALNYPTIASVMHSFVNSYKNVLAISLATDYEYEGSAKLKEMLANPEAFAAAAAAAAPAADAGEAAPAAEEKKEEPEEESDGDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR05</accession>
    <name>A8PR05_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732786.1">
        <property type="nucleotide sequence ID" value="XM_001732734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR05"/>
    <dbReference type="STRING" id="425265.A8PR05"/>
    <dbReference type="GeneID" id="5857092"/>
    <dbReference type="KEGG" id="mgl:MGL_0561"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0561"/>
    <dbReference type="InParanoid" id="A8PR05"/>
    <dbReference type="OMA" id="VIDIGWY"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29804" checksum="1D8E4C0D3BC04C11" modified="2008-01-15" version="1">MHVPSVSFVDSHVLCTLAVGRTSALVVDVGHLETCVMPVYDGRPMQNLITTTPRAGRFLSRTLRALLARHAETTAPIDDVLHPSTIDEVQTRALLVGEPCTCSRTTVSPLDVDAFASEYAKHATNTSAWSLRVHGQSVLHVPGWLRERACEVFWEPGDEDEASVVECVWQCISRLPLDTRRELLGSILLAGGSSLIPGWTQRFVQELQKPGLTSALQYGAASMPTDPTHAMRVQVLNASATYMPANVLAWSGASIAGHLHAEGTTVWTRDSWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR14</accession>
    <name>A8PR14_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3,4-dihydroxy-2-butanone-4-phosphate synthase</fullName>
            <ecNumber evidence="2">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732795.1">
        <property type="nucleotide sequence ID" value="XM_001732743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR14"/>
    <dbReference type="SMR" id="A8PR14"/>
    <dbReference type="FunCoup" id="A8PR14">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR14"/>
    <dbReference type="GeneID" id="5857101"/>
    <dbReference type="KEGG" id="mgl:MGL_0570"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0570"/>
    <dbReference type="InParanoid" id="A8PR14"/>
    <dbReference type="OMA" id="DCFAFAN"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="172" mass="18777" checksum="04347F02ABC78848" modified="2008-01-15" version="1">MLTPPHSGFVCISLTPERLNTLRLPMMVPENQEKHKTAYTITVDYRHDTTTGISAHDRALTSRMLADPSLGATAGDFSRPGHMNPLRYTPGGVQVRQGHTEAAVDLCKAAGLPPAGLLCELVDPNDQMGNIAARDASLAFARAHGLKVATIEALRAWQQQQQQQQQPSRPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRA9</accession>
    <name>A8PRA9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_0010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732235.1">
        <property type="nucleotide sequence ID" value="XM_001732183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRA9"/>
    <dbReference type="FunCoup" id="A8PRA9">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRA9"/>
    <dbReference type="GeneID" id="5856535"/>
    <dbReference type="KEGG" id="mgl:MGL_0010"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0010"/>
    <dbReference type="InParanoid" id="A8PRA9"/>
    <dbReference type="OMA" id="KKGMFTF"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="15">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="450"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="140"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP45021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="727" mass="80210" checksum="332B8E76BCD72CDD" modified="2008-01-15" version="1">MHPQMLDHLRLMQLRGSEGAFVAQPGGTDLDRFTPRRQAPNPPGNAPQTPPKLPAGVYQSHNPPLFSNMQVHPGSNSRPMKQPTLPHTVVNDQVSMWSPPPNMQSLIEPASSPSSSSRWNSHTRSQSVDTYWMRPSNCTESHRMQTDGVHQGLPQPHMLSKSKSNRSLLGSNSRRTSLEGQGNVRMSEVSGSGTPRSIKSMIDGLVNSMSDAFGTPKRPDISTPYDPVHLTHVGFNASTGEFFGLPKEWQSLLQQSGITLQEQEQNPQTVMDIVAFYQDAAQERPPGDENDNVWSKFGANIDDSEDSEEWLSDAYGIETGATGPYLQPQAPSTPSTPSKRPLPTPPAHAPTFRPPELLNSNKGSLTEPHVEGITSRPYTSNPFPGKAEILVRSHSQKALQTMPGKDADLRPPLGGAVVPRRRTQRTKASDAEVYARIRAICMPGDPKLLFRDLHKIGQGASGGVFTARSIVSNQLVAIKQMVLAQQPKKDLIVNEIEVMCQSRHPNIVNFLSAFLRQDELWVVMEFMEGGPLTDIVLHSILSEGQIAAIARECLTGLRHLHAHGVIHRDIKSDNVLMSMRGEVKLTDFGFCAQLSPAQSKRVTMVGTPYWMAPEVVTRKEYGARVDIWSLGILCIEMIEGEPPYLNENPLRALYLIATNGTPKLQNPDKLSPTIKSFLATCLEVDVEKRPDATNLLSHPFLQHADDLQTLIPYIQAAHELRERNASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRC1</accession>
    <name>A8PRC1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0018</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
            <location evidence="2 13">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732243.1">
        <property type="nucleotide sequence ID" value="XM_001732191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRC1"/>
    <dbReference type="FunCoup" id="A8PRC1">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRC1"/>
    <dbReference type="GeneID" id="5856549"/>
    <dbReference type="KEGG" id="mgl:MGL_0018"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0018"/>
    <dbReference type="InParanoid" id="A8PRC1"/>
    <dbReference type="OMA" id="FAGTRRN"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 13" id="KW-0243">Dynein</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="124" mass="14159" checksum="81C5EEF9E8905207" modified="2008-01-15" version="1">MLSLENNIHPVRPPRSDAIVREMEARNQDSVPPVSSDETPRAIIKNVDMEQDMQLAVIELAADAMVRFAVEKDMAAHIKRTSDDRFGPTWHVIVGRSFGSFVTHESKHFIYFYLGTMAFLVWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRS8</accession>
    <name>A8PRS8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732344.1">
        <property type="nucleotide sequence ID" value="XM_001732292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRS8"/>
    <dbReference type="FunCoup" id="A8PRS8">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRS8"/>
    <dbReference type="GeneID" id="5856650"/>
    <dbReference type="KEGG" id="mgl:MGL_0119"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0119"/>
    <dbReference type="InParanoid" id="A8PRS8"/>
    <dbReference type="OMA" id="GFRYTYA"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="140"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="536" mass="57820" checksum="F99924F3E84ACA04" modified="2008-01-15" version="1">MESRNKGHAHGHVLDETPDARTDPRLAVIHDQQGNAEESHIITASESPGSKHASTKLPDPWALRDSPTPLSPEAPAAPAAEQPSLRVPVGFRGPQPHEDDAQDTAPAPTWIPYASSVGALGTVPNVPMNKNGWRYVAAGPAAHRLPRTVYRAIDMAPACVHWSWQDRSAFTRISHDASIVGTDKGYRSARTNVGVRHGAWYVEVEVLSPDASSEPATPMRDGAHVRVGWARREASLNAPVGCDAYSYGFRDQNGACVTQSRLVSFGRAFGPGDVVGMYIRLPDRDAPLPRGTEHGIAQKRIPIRYKGQLYFESLEYAPTREMEALMDEQRRTGAVWTSEPRARAGVTTTVGAGGPTGAGPSSAGPSARGGAAAQAGSPGSAAAAIPRLEDSCIGFVVNGEPQGIAFVDMYDFRPPASRAHNKKRKENQGITPNTSASTVIKSRQNTMDDGMLGYYCMASMYGGARVRLITSNFKFPPPADLEDSLWRAGAAPNIRHHRQHAAPAWRPLAERYAEAWTEAMFLDEQEDQRVASTDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRS9</accession>
    <name>A8PRS9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732345.1">
        <property type="nucleotide sequence ID" value="XM_001732293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRS9"/>
    <dbReference type="FunCoup" id="A8PRS9">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRS9"/>
    <dbReference type="GeneID" id="5856651"/>
    <dbReference type="KEGG" id="mgl:MGL_0120"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0120"/>
    <dbReference type="InParanoid" id="A8PRS9"/>
    <dbReference type="OMA" id="EVFEIDM"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="118"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="220" mass="24000" checksum="AEB9ECAC2495A15B" modified="2008-01-15" version="1">MSSSDAAVETPTVPASAPGTASTDVDPFPARPTRYCEVCTFPYEYCEYGSSLSKCKANLEARDPTLYAQLYSDAALEDKLKSLTTEQAESLERDSAKKERKAQAKAEKERAQLAASKVILSRVSRTKRKVITCVHGLHQFSPPLPALKVIAKGLSSSFATGASVTQSVHNPGIDEIHIQGDVVDDLRTMLIERKKPFDQMPSEADGGLHEKNIVFDEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSF5</accession>
    <name>A8PSF5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Magnesium-dependent phosphatase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732473.1">
        <property type="nucleotide sequence ID" value="XM_001732421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSF5"/>
    <dbReference type="STRING" id="425265.A8PSF5"/>
    <dbReference type="GeneID" id="5856779"/>
    <dbReference type="KEGG" id="mgl:MGL_0248"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0248"/>
    <dbReference type="InParanoid" id="A8PSF5"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="6446" checksum="8F3D1F2FCB53E3C4" modified="2008-01-15" version="1">MKHAVLTSKALFDYLEIYPGSKTTHFRRLAEVTGIDFRDMLFFDDEHRNGMHLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSF6</accession>
    <name>A8PSF6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase (cysteine targeting)</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_0249</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732474.1">
        <property type="nucleotide sequence ID" value="XM_001732422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSF6"/>
    <dbReference type="STRING" id="425265.A8PSF6"/>
    <dbReference type="GeneID" id="5856780"/>
    <dbReference type="KEGG" id="mgl:MGL_0249"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0249"/>
    <dbReference type="InParanoid" id="A8PSF6"/>
    <dbReference type="OMA" id="CYVCIAK"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="18">
        <location>
            <begin position="53"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP45260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="495" mass="57317" checksum="430F20F1D3A44813" modified="2008-01-15" version="1">MSRVSETATLPFYEGAFVQASPEIERIRKDLPNFSSPELRVQRVGQLDSHLLDQELADLLTQPVKNALRKVSPKFEQRYNSEILVALRLILYKFSIYDRGATYGAMLQNLKYRNEWAHRAHCTYRENLTDFIFTVHSTARDAPLSSVQLALHPLLTIILPYMYSKAKSFMSSRQYDLAPTESLQFIAYSLSEHWQRLWSLIGLVNFSLFLWNGKYRTVADRLLGMRLTYANRALHHNVSFEFLNRQLVWNAVMEFLLFIVPLVRPKHLFHLLTLLPKHQNVLKTLLKIMPTKITDKLSLRLDMYNNVEYYGYDMFEPRGKYWYLPVECCPLCFERLEREAGVNVHQVPIPMSIKDEVSIPTPDPLHPCKGLAARHKKKADKSDSFNENESKKIAVRAAKMAERRAARKGASSMTIDRNYCPTVHDTSPNGIRFLDALAFIPYATQGKKVICNCRYCYSCIGRKFKEELTSVDLRELGGWPCLRCGDIIFTAERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT08</accession>
    <name>A8PT08_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732573.1">
        <property type="nucleotide sequence ID" value="XM_001732521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT08"/>
    <dbReference type="FunCoup" id="A8PT08">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="GeneID" id="5856879"/>
    <dbReference type="KEGG" id="mgl:MGL_0348"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0348"/>
    <dbReference type="InParanoid" id="A8PT08"/>
    <dbReference type="OMA" id="TAWANMI"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP45359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="328" mass="37191" checksum="71A03EB8FC519477" modified="2008-01-15" version="1">MFDPIRIKLQHWLDRNKPLAKNKISELGHRWNDFSGYADINALKEQVEVKAERLKTLQQEKDAAKEVYIQAVSDRSVSQRRVNDLLSRKSTWRDSDLMEYTSLLHSEHSHAKAEEQSQLEYERAEDNMQRGFDDLMRSVMRRYHEEHIWSDRVRSISTYVSVGLGALNVLVFILALFIVEPYKRRRLAQTLESRLLSGEEAARHRMHATMMSVDERLADIESSVCPPPTAAGVRATDAPVASDAGAGTGRGVSASIQRARDIMKRGASFAWVSQVMHYLHMCRVYMATAWANMIPFHTEQGAITHLAATTTGVMVGSVLSYVLYLALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT59</accession>
    <name>A8PT59_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732597.1">
        <property type="nucleotide sequence ID" value="XM_001732545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT59"/>
    <dbReference type="STRING" id="425265.A8PT59"/>
    <dbReference type="GeneID" id="5856903"/>
    <dbReference type="KEGG" id="mgl:MGL_0372"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0372"/>
    <dbReference type="InParanoid" id="A8PT59"/>
    <dbReference type="OMA" id="MEATNRK"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000257">
        <property type="entry name" value="CCR4-NOT core complex subunit Not4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="678" mass="72277" checksum="FF0E33ABA10639AE" modified="2008-01-15" version="1">MRLTNAKKNKEREKREMEATNRKHLANMRVVQKNLVYVVGLSPKFAREEFIPTLKGPDYFGQYGRVAKILISKRMTSHKYGHGSHDPSIGVYVTYQSKEDAARAIVAIDGSKEPGGRMIRASYGTTKYCTSYLRNMPCANPGCTYLHEPGEEADSFTKEDLATLRHAAKDTEHKIKPASMHLMPITKKATESSMSMTGSPASTHVTAATSSSATTAPTSHSDTGAEGSALPRTASWATAGKLYSTPEQTHAQPVSASATQSPPLLTQDPHAFPGLAAAMKEVAKPMPSPKARPKSMAKPAVAAASSAPAGKTNKSLATDSVPSSPTTSFHARDDEPFKASSRDTPGATHERHHPSLDAVEPPSLFSTVDWTLSSLSDGDFSFHLPSLPPASTMASTTSSNLLAPSTAMDAQASDSVDDHDTGMYTSYNGTFNPFDEHSPDVSWASIRAPPTADTSTPSSGVPPPGLFYEQRRTPLTSYHGAADVPWFAQPQPQTQSQSQTQRPQAPLPQLQPQSSLAEHQSLHAYQQHAMQRAAVAVAMPPMPSVMDSVRAPEEQRSAAAAMLAARARQLQEAGENVAAHSMSDVRTNLARQQAQAKNGDSQSLLALLRRIQDVPPEHASGTPPSESVPAVTPPPGLRPSAAPQPNMATGLLLAQLLGTPPAKHPAEGYAGVPILKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTB1</accession>
    <name>A8PTB1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732621.1">
        <property type="nucleotide sequence ID" value="XM_001732569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTB1"/>
    <dbReference type="FunCoup" id="A8PTB1">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTB1"/>
    <dbReference type="GeneID" id="5856927"/>
    <dbReference type="KEGG" id="mgl:MGL_0396"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0396"/>
    <dbReference type="InParanoid" id="A8PTB1"/>
    <dbReference type="OMA" id="NTEHIER"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="115"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22383" checksum="22432408260BDF7B" modified="2008-01-15" version="1">MSGALSSSCRYDFYQTTADVVVNIYARNQPEKDVKVQLERDAVMLISSPCFSEPLVIPLWGQVTPNFTVRVLAPKIEIVLKKKEPSVTWVALTRDATQSPASSSTVASQAASAEAHSSSSARPSSKWDTLDLSDADDAPPAGSGDAELNAFFQKLYADADPDTRRAMIKSFQESGGTALSTNWEDVSKQTMEVRAPDGMVARKFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTH9</accession>
    <name>A8PTH9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732652.1">
        <property type="nucleotide sequence ID" value="XM_001732600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTH9"/>
    <dbReference type="FunCoup" id="A8PTH9">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTH9"/>
    <dbReference type="GeneID" id="5856958"/>
    <dbReference type="KEGG" id="mgl:MGL_0427"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0427"/>
    <dbReference type="InParanoid" id="A8PTH9"/>
    <dbReference type="OMA" id="EDQWPEM"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="175" mass="20570" checksum="760FDA525906D00D" modified="2008-01-15" version="1">MGSKPTPRQVVVILAVKQDTTQSKEDRILVCLVKSRKHENKWVLPKGGVEKNETVEEAAVRELWEEAGIRTKSLRPSWTEARNRVSHADRRPHSKCPKELIGTDKMVPKTMYELEELSVTDDEMMDEWPEMHERERQFFRWEEAKELVAWREGMRELMDKSNIEQTGFIEVARAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTR4</accession>
    <name>A8PTR4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732691.1">
        <property type="nucleotide sequence ID" value="XM_001732639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTR4"/>
    <dbReference type="STRING" id="425265.A8PTR4"/>
    <dbReference type="GeneID" id="5856997"/>
    <dbReference type="KEGG" id="mgl:MGL_0466"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0466"/>
    <dbReference type="InParanoid" id="A8PTR4"/>
    <dbReference type="OMA" id="RDLWIEM"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="723"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="89338" checksum="9576C7275F7987E2" modified="2008-01-15" version="1">MRHLRRHTPVHVREAELRREIAQLEQQWHDLQKRDRIEALTRDLPPLEESTLDSMYQELVSSPLPDVRQLESPPPTTPKLSLEQLAARLGLPPVQTLPKTGDTSIDTTELAKERKQLRAQILERLERSGVEFCQQQQTEASDLSPCTQTASGIVPPSAWLALAIQSARDHDTEHVNTTLALAARSGMHVSPLFHKVMDAYANAGLVEPVLELSAAMQANGILPQPETKHIVVKAYAKMNQLFDAVQYLSLWEQSDPAPMSSYTLVIEHVLKHPIRDLHPIAWSLFYHMRYAAHPVPDAPLYAMMIRACAAGIPQPNTMSIRRNRSWEADAERALDLFREMTVHHGIRPNKEVYDSLILTCARRKEHYSDALRLLRELVDGNAHGVAPLSPDVYTYNAVLQGSARKGDLITSRWILADMVRSVMTQADSADGTSKAPNEETLTNVFWSYAVYRPPIKRSDLVTVQAEAGPRRSENDMHAILAANEEQRARSSNAQPSFSQNMPQTSSDVLMEVRSLMARILADQGHSVNSNNAVDLREHPMRFVAITPRLLNAFLAVFTHHMKPDQRLRALFNAVYEPDGVFAQSHVQANGHTLAMVLAECALSKDRALADQVAEQIWDQWTALEGSSLSSQNTSVRRDTGTDAKTISKMWALMIRQHAKSFRVEPALTLLRSFLEKYPPSSRAVPKTSVTTQAPLPPLDWMPIVPPMSMLRLLYSLPPGTAHSSTPSLSSSMQSRPSLPLPQSSTSASTSSYSPLSPLRPKLLFRDLELLHHRCVALHHVAGLNLITRVDREYRREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTR6</accession>
    <name>A8PTR6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.1.150</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0467</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732692.1">
        <property type="nucleotide sequence ID" value="XM_001732640.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PTR6">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTR6"/>
    <dbReference type="GeneID" id="5856998"/>
    <dbReference type="KEGG" id="mgl:MGL_0467"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0467"/>
    <dbReference type="InParanoid" id="A8PTR6"/>
    <dbReference type="OMA" id="QSVWNDT"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="246"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="1913"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="471"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1335"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1427"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1713"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1776"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1335"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1361"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1439"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1455"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1495"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1526"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1608"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1624"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1713"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1780"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1805"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1833"/>
            <end position="1845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="2249" mass="251365" checksum="3E56EF0C5C080603" modified="2008-01-15" version="1">MTASLSVGGLYSYVDNPQPATGTAASSTNTSGTRSTSQNDASARLPASEMVSFGFLDENEERPPPTFAFASLFDRMRAAFSAPSSGDTHKSDYAPATPARRLSPPRRRISRHGTPAQRQPSQHHRKANGIVPLRTLSPSVTIAPTNVVSTASDVGSHTATVLSDTESVDTRQSDRGTLGTHGVQAVPGFPLSGDILDDTRSVTTIHRSRSDAGDDSLSTMSVRPSADIWIRRFRGEGLSRKYWMADETAKECRDCLMPFTSLRRKHHCRICGQIFCHRCASNLVPGERWGHKGSIRTCNQCKNMLEEYDHRERIDAEAREASFLQEQSPVSSSMPEVEAQDLHTPLSQFAAKTLFAGNASALPRRCERYRFNGESDDDGNDDNGDMSDERLSHEQDVHDFQSYRDDEFNEMPEMDGRDVEPLRNLSAHDPILIHDEVPFRSGLVDESDVQAADESITADMVSSMIPASRNTDEMRHMRDSDLTENSRYTDEASRSGDSGFKVRDENDEENDIVCSKPHQRDTLTEPPLVAHDDANEKPLPPPCSPIKRSTARQKLMRGASRFVTSTALSAISLVYFLRMLHQLLLAEHIGHVHEWKETIKLLALAVIERIRVRTRNTYLTDIRHFVKIKCFPGGHVSDCEFLDGFVCTKNVATKPMASFLPMRNARIMIITFPIEYHRNADQLMSLESIMAQEYEFLRILVARIVAQRPNVVMVQKGVSHIALEMFEKAGIAVFLRMKRTALETIAHCTQADIIASIDRLALEPRLGRCAAIFIDTYQQVDDAERRKPLLRVEVTSKEVSSALVLRGALLPKLRRIKAILALMVFVGYNLKLEDFLRHDLGALLEWSAMNYHSVSELPASIQADESEIHRRIILDETLKKYQRLLLSASVTAILPPPFLVTRMKQVTDRIHTLRAEPFEQVTTTHYPRNDGEALAGSNLVLCAPCTYRAATEQAILESEHESIQACWHACVSGMSKMLTPFAHQKLVALVFKTCAATLQTCTGPDFVMTEFYGLNDEPLGQFLERTCFESAMPCDSRHCESSNLVHYLTFVHNTTRIQMVVEQFPCPLAGSENELLCWSYCKVCESTTPITHLSDAGWSVSFAKFLELQCYPNAACHSSMCPHDYFRDNVRYFALKNLAIRFHADPITPWHIVVPPSRLVIHHELMCELRNAEVIKLYEKNLRYWRSVCVRLTALRDELHAHPIYSEAPLTRIKMHADDLLEHILQCASTDCAEVEERISQAYWHSDKSPLKMNEVRRFLQDRVVEWEGLFLDFEKRSTVTERDVRRLMELYRHRLQSKDADDMSVESDAQLDTPTDRKMLDFLTFLDGCAGYDKDSTKHRNEETQRMEDSKLVSVSIDSHASKERQSSLEAPRTKSRADAPSKDSAMTSAIAAAVVTTGTAAAPATPASATSSTAVPMTMLASRCGQLQSEDRKPAQSRGQHPNPSTRSSSEQSPREGQSHEHSSSQAHPIRDSRPASQDQCRVSTPGPMPKASTLTGPASSMPSTTHKPASRVQEVSQKRHEMSNASDSPTSASNISTQTAARQDVDPAASSPTAYVQRSPPASIRRKHISEHGSMSPSSEHKRADSRTSPQKSSDQREQTPRSTPGAAPLSSPASSLGHSRPTSQLFSSQAAMRCESMVLRPPWNDSRPKINKPRRDVPTRSQVAILARQYEQLSRDAELERDRLASRIRRTRPATTTHATVEVFKSLRDAVKGDESDGEDEGKQTEQAHAERRGEAWLGKDAGPGSALHPFMNTPEASASVAGEAVALTPNTGGLTRASTSPATSADAAGSAESLGPGSLGATSERTLATTPLSNMSMSTDPRGEAPQPSDTGYTQASMQTAPARKESTNESEPVATPHSDSEEALPERARLFRLLEATWTLHVGELVPLKYPFVSTDHVFTDARVVVREDEPSSIIAFTLDSKSYREQLAESRKLRTRDVPDAAPDMEQELRITEGSHYLYEFDTGSIKLWCKIFFAEQFDALRHMCGCAELFVQSLSRCFKWDSRGGKSGSAFLKTCDDRFVVKQLSRTELDGFSKFAPQYFTYLADCKSASRPTTLTKIFGYFRIGFKNMHTGKGFKMDLMAMENLLYGRSIDKIFDLKGSTRNRYVQETGRAGEVLLDENLVHDTRTNPFLVREHSKRILRTALYNDSLFLTEMNVMDYSLILALDSKRNEMVIGIIDYLRTYTWDKRVESFVKETAILGGGGKGEPTIITPRQYRMRFLTFLDRNILMTPDPWVQSGWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUE6</accession>
    <name>A8PUE6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732076.1">
        <property type="nucleotide sequence ID" value="XM_001732024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUE6"/>
    <dbReference type="FunCoup" id="A8PUE6">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUE6"/>
    <dbReference type="GeneID" id="5856382"/>
    <dbReference type="KEGG" id="mgl:MGL_0669"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0669"/>
    <dbReference type="InParanoid" id="A8PUE6"/>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="160" mass="18379" checksum="AB1AF4569FC66F4F" modified="2008-01-15" version="1">MAIQWVLLISRQGKVRLAKWYGTMSHKSKAKIVKDVTQIILARRSRMCNFVEYKDNKVVYRRYASLFFVAGIAPDDNELTTLEIIHRFVEVLDRYFGNVCELDLIFNFQKAYQVLDELVIAGELQESSKKSVLRVVMQGDAVEEAENNEDNLGRIGSRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUH1</accession>
    <name>A8PUH1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein OS-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732092.1">
        <property type="nucleotide sequence ID" value="XM_001732040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUH1"/>
    <dbReference type="STRING" id="425265.A8PUH1"/>
    <dbReference type="GeneID" id="5856398"/>
    <dbReference type="KEGG" id="mgl:MGL_0685"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0685"/>
    <dbReference type="InParanoid" id="A8PUH1"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005660912" description="Protein OS-9 homolog" evidence="6">
        <location>
            <begin position="24"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="369" mass="42110" checksum="97A0C96510523D47" modified="2008-01-15" version="1">MLINKMKVAALLPLLACATLCWGQSKKEISNILLQDKYVIRFQNRTVPRTEALQWLGELPGTPALTSPDYADWDGEAKFNVYRITEAETYLCRVPLFDNTFVSKAPDDRRMLSSSETDRILSRGLELLKNLTDRPLNIEFGYFSHVLRYQKYILQFPRNDWNDNNVVAKVEGREQLPEGYYLLGMWNSDVRVNSQIAPYYDVPSADLEEEIMAPRTDDALYIQQVWQNGTICDLNGLPRMTTVKVHNEKEREEYLNKVDEHHGVKHNGDKQVVDTTLQFVDKMAAKEGDAKEVHVSLLNSDGQLSTDLEKVLDSFLHSRKHTIYPVSNQNAAKQAEENKVNEESPTTLAEASQSTEASAEPLDDRLQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUJ8</accession>
    <name>A8PUJ8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0702</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732109.1">
        <property type="nucleotide sequence ID" value="XM_001732057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUJ8"/>
    <dbReference type="FunCoup" id="A8PUJ8">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUJ8"/>
    <dbReference type="GeneID" id="5856415"/>
    <dbReference type="KEGG" id="mgl:MGL_0702"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0702"/>
    <dbReference type="InParanoid" id="A8PUJ8"/>
    <dbReference type="OMA" id="ANEWETQ"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002724987" description="Cytochrome b5 heme-binding domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="55"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="176" mass="19448" checksum="C6316483F0C49AEA" modified="2008-01-15" version="1">MSILCVPLAVYLLWPPEASSPASMPSTKEARSLAPSAQYSTLPPEHSKSIEWVKYTPRTLALHDGTHASQDGNTDKILLAINGQVFDVSSGRNFYGPNGPYGNFAGRDASRGMAKQSFALDVLTPIDQPIDKLEDLTELERHVFIELTCRKNMEDWVSHFAGKYPIVGELVNEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUK5</accession>
    <name>A8PUK5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732113.1">
        <property type="nucleotide sequence ID" value="XM_001732061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUK5"/>
    <dbReference type="STRING" id="425265.A8PUK5"/>
    <dbReference type="GeneID" id="5856419"/>
    <dbReference type="KEGG" id="mgl:MGL_0706"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0706"/>
    <dbReference type="InParanoid" id="A8PUK5"/>
    <dbReference type="OrthoDB" id="2585251at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="267" mass="29592" checksum="ACD3EF0EEDAF8672" modified="2008-01-15" version="1">MKRVHLPRGPGLHVSTCHGPGLQSARAFSSGGAGARLFENMVTDAPLAIRAFGNKFKDEAHVRESKSLRREARAAKTQLKAVRGVMPLNHYGLASLCAMEPGALTNLDSVNADDMELFFPLAKTSSACAGPFQGVKTVLTVALDPYTPMIDGKSEVLRSQNMPQVSASLLDENMQSKLHQIQARYKHHHECIKLLEAVLRYHNMWPSKLDMSCVEVPIVSNKPVFLRIKIPGWRKPDVEAALRDVPKHVIHLHSHPLDCLWSLMEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVF4</accession>
    <name>A8PVF4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731579.1">
        <property type="nucleotide sequence ID" value="XM_001731527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVF4"/>
    <dbReference type="GeneID" id="5855885"/>
    <dbReference type="KEGG" id="mgl:MGL_0847"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0847"/>
    <dbReference type="InParanoid" id="A8PVF4"/>
    <dbReference type="OMA" id="PGMNARI"/>
    <dbReference type="OrthoDB" id="3360637at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="680" mass="73991" checksum="120B7436E08C5C84" modified="2008-01-15" version="1">MGSMIQQERVSRGNEIASQDSCLLWMMGCSPPKQTGGSNLGKLLKATPSKAELSTYTVPVNFFTATPPASVSYASSDDETPLSSKSGITTPHSLLFQNSHDNLPFETGLESTTLGSSWSSSSKFCGSFESQESAPTSCEEVSPESKASIDGSIPSASTSATGDSLEALCELLQSHKLGFEESNHRAEPQSNLGPRSESWQTIRMKQKEGSDDEAPFSSSSSTLGQEVTPSNCASDMSPPPSPSSMGPPSLDPLGPEDLSAYVSGIGLPIDPDIEMSTFVQLQTFRHHTRSRSVGRFDSRHEKSKWRRPDRSKMDERTANMLGLSPRKLQSMASPRPPLALVRDTEHIPALDGLGSALCNPGYVLHSRNSSVSSFSETFDDEPPASPILRTPTEALEPLPDDGDFSLSLSDASVPDELPSEHVTIEHLQPLVTDTQQLCMTSEEPPLADYTLGDNLSKTSLTRSSSLDCDDDVPVSRGRCTSVKSIKSPSSPVVSGAKLGVSHRRSNRRRKNESSSGSSQTRPQAGLNLELRSREKERSLGKQRGRGNAVKVVASSSDECAESTLNPAPCDDMKGSDDESVLDVAQALPRSRLLSNSSHLLMLSLELAMIHHHKINAPLKPRWGRRRDDDFQPLPGMNARIQRYMAERKLRHVPSSVRTSSMYHYVDECGSRLKYNWDART</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVJ0</accession>
    <name>A8PVJ0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731615.1">
        <property type="nucleotide sequence ID" value="XM_001731563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVJ0"/>
    <dbReference type="STRING" id="425265.A8PVJ0"/>
    <dbReference type="GeneID" id="5855921"/>
    <dbReference type="KEGG" id="mgl:MGL_0883"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0883"/>
    <dbReference type="InParanoid" id="A8PVJ0"/>
    <dbReference type="OMA" id="NAPHETH"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="595" mass="64717" checksum="83DB3A34B8ECF97A" modified="2008-01-15" version="1">MHPELDFLDECLCTLRHVRGTSTPVLPSPVMDAPDAQLDLQSVHSQSFVAALRLRPVSNDVYDALIDLYERVLEQLKRMYMDHFHDAQMRWGSARQRVLPQIQRLFEVQCQMAARDMQKAILSLVDDRLKTFAADANAPHETHRPHSVRATAILERAFAHAPNITQAEKYKLAQATGLQPRQVTIWVQHACTDNPLQFQNRRNRRAHARRAAIVDSGLVSPEPELPPPPRLEAPPPPPSVAAARVGQTDDGKDDMLVEGEESGASSLSDWASATTVPSDSLSFDAPIRPFGSSSPAQLANSTFSTSPLSTTSSLILHASQPHMSPQMQTQAQMTPVPQAHTQTQAQGHTQLPIQVASHPPPPSIPLQSQASMSMTPFQAPASPATLSTAATATNTTTRASSLSSTTTTCMPSASTAPIVSLDQLLDLDNARQCLVFSPLDLLPRLDFDDLRLDVPTIENWLGLPSTPGVSSLHVPPISAGAMRSAKLALSQPLNAPDELMGRAADEGWSLSEQLTPLWNVPTDAHRLSDLSLRIDGTMLRRDSVMKAERMAPPPSAPLTTQSYPLPLSARWNHDAIAPNVLTWDLSRGISSTLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVV7</accession>
    <name>A8PVV7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731697.1">
        <property type="nucleotide sequence ID" value="XM_001731645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVV7"/>
    <dbReference type="FunCoup" id="A8PVV7">
        <property type="interactions" value="473"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVV7"/>
    <dbReference type="GeneID" id="5856002"/>
    <dbReference type="KEGG" id="mgl:MGL_0965"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0965"/>
    <dbReference type="InParanoid" id="A8PVV7"/>
    <dbReference type="OMA" id="QMSMQDQ"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="351" mass="37115" checksum="677FE0E0C08671D7" modified="2008-01-15" version="1">MRNGDYVPTRWDAQADAVNVLFDAKTNSHPENMVGVVTMAGKSPEVLATLTQDIGKVFAGLHASKLAGAISLCTGINVAQLALKHRQNKNQRQRVIAFVGSPVSDSEESLLQLAKKLKKNNVAVDIVNFGEFEENETKLSKLVDTVNSNENSHLLTVPTGAGPLSDTLLSSPIVLQGSDSEAGPSGTAGGGGSSGNDFQFGVDPNADPELVMALRLSLEEEQARQRAAQESQPDGENPPSAPETKHPAEGATGSLVPVDAPPLSGTSGTDTDMSHQAENEDELLKQAIALSQQDSAPEPQEDVQMDSGESNQQRAVVAGPNEGDQDEEMTEEEAIARAIEMSMMDSKNPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW51</accession>
    <name>A8PW51_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731759.1">
        <property type="nucleotide sequence ID" value="XM_001731707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW51"/>
    <dbReference type="FunCoup" id="A8PW51">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW51"/>
    <dbReference type="GeneID" id="5856064"/>
    <dbReference type="KEGG" id="mgl:MGL_1027"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1027"/>
    <dbReference type="InParanoid" id="A8PW51"/>
    <dbReference type="OMA" id="QAARMWS"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="229" mass="26049" checksum="FFAAB379141F1111" modified="2008-01-15" version="1">MVKMTLPSSMLALRAPAAVRYAAPPLLSLSRSIFTGAAIMQAPQPFRQIPKAHVLAQTATPKTPLDVAKSYPDHPLMQFFQMVPMEIPKEGTQGRHADERESIPVPHSVTESDLKRDFGSRAWLAPELRRKSSADLHTLWYVLLLERNKLATSWEELKRHRADGSAHMLGQSLSHRHHRVRKSMARIKYVLNERRLALMEAQRRAREDVEIPPEDAFDGDLFEKSPYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWJ2</accession>
    <name>A8PWJ2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731851.1">
        <property type="nucleotide sequence ID" value="XM_001731799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWJ2"/>
    <dbReference type="STRING" id="425265.A8PWJ2"/>
    <dbReference type="GeneID" id="5856156"/>
    <dbReference type="KEGG" id="mgl:MGL_1119"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1119"/>
    <dbReference type="InParanoid" id="A8PWJ2"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="56" mass="6148" checksum="586E273D89B3717B" modified="2008-01-15" version="1">MVRSYERHEATAAFGLIGSNAANAILDADGKTAYLPALEDVLVWDVKRGEQVRMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWZ6</accession>
    <name>A8PWZ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ATP-dependent rRNA helicase RRP3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_1272</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732004.1">
        <property type="nucleotide sequence ID" value="XM_001731952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWZ6"/>
    <dbReference type="FunCoup" id="A8PWZ6">
        <property type="interactions" value="674"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWZ6"/>
    <dbReference type="GeneID" id="5856309"/>
    <dbReference type="KEGG" id="mgl:MGL_1272"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1272"/>
    <dbReference type="InParanoid" id="A8PWZ6"/>
    <dbReference type="OMA" id="GIGIKCC"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="56"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="250"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="418"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP44790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="51606" checksum="74B35710FF61ED60" modified="2008-01-15" version="1">MSSEDTAHATPHADAPDAEEHEKASSFSDLGVIEPICEACEKLHFSAPTDIQAQAIPHALQGRDVIGLAQTGSGKTAAFSIPILQGLWDDPRPLFACILAPTRELSYQISQQIEALGATIGVRCATIVGGMDMMTQSIALSKRPHVIVATPGRLQDHLENTKGFSLRSLRYLVMDEADRLLDLDFGPIIDKLLQNIPKERRTMLFSATMTTKVAKLQRASLRNPVRIEIGTKYSTVSTLQQYYLFMPFAHKDTYLVHLANEQVGHSIIVFTRTVHDAQRLAVLLRLLGFSAIPLHGQLSQTARLGALNKFKAGGRSIMVCTDVAARGLDIPAVDLVVNFDIPTHSKDYIHRVGRTARAGRQGRSVTLVTQYDVELLQRIEAAIGKRLDEFPGAGDRDMIMLLSERVGEAQRAAIRELQEKGFGNAGGAGRRKRKQAVGLEDERDRDDDTVEAGAYRSRATKAGGDGKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX08</accession>
    <name>A8PX08_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732016.1">
        <property type="nucleotide sequence ID" value="XM_001731964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX08"/>
    <dbReference type="STRING" id="425265.A8PX08"/>
    <dbReference type="GeneID" id="5856321"/>
    <dbReference type="KEGG" id="mgl:MGL_1284"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1284"/>
    <dbReference type="InParanoid" id="A8PX08"/>
    <dbReference type="OMA" id="PRIICTR"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="103"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="262" mass="29229" checksum="A1210271E85ACD02" modified="2008-01-15" version="1">MTLTMVTRRMQYIVNVPRYAPRFLPNIPAFATKAAPFSPIILTSRTFSATHMPQKKKNKGAVNEKMAEPMDATPQLDLNGTSSEMESVVARCSEHVRTLVGSLGRVDAALLDDVRVSTGKGIKPIPLHNFATVGVRDNVLVITAYEPETLKHIEKAIYAVGKDLAPQIMHDEEGVMIVHVPKPTGETRKILLQKCIKECDHAKTMLRNVRQSAQKHMKHDSDNKILSKNEAQKESKKLEEITKKHTALLEQVAAESHKRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX89</accession>
    <name>A8PX89_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731182.1">
        <property type="nucleotide sequence ID" value="XM_001731130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX89"/>
    <dbReference type="FunCoup" id="A8PX89">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX89"/>
    <dbReference type="GeneID" id="5855489"/>
    <dbReference type="KEGG" id="mgl:MGL_1365"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1365"/>
    <dbReference type="InParanoid" id="A8PX89"/>
    <dbReference type="OMA" id="MWLTDAQ"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="138" mass="15082" checksum="75AAEAC74C2AC6ED" modified="2008-01-15" version="1">MWLTDQQKIGVGLVSGGVFFLALGVIMFFDATLLAMGNVLFVSGIALLIGPQKTLLFFARKQKIRGTVCFFTGMGLVFLRWAIVGVIVETVGFLNLFGDFFPVILSFMRQMPIIGNVFSLPVIGQVMDQLAGTRRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXE6</accession>
    <name>A8PXE6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor EFG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731239.1">
        <property type="nucleotide sequence ID" value="XM_001731187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXE6"/>
    <dbReference type="STRING" id="425265.A8PXE6"/>
    <dbReference type="GeneID" id="5855546"/>
    <dbReference type="KEGG" id="mgl:MGL_1422"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1422"/>
    <dbReference type="InParanoid" id="A8PXE6"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor EFG" evidence="1">
        <location>
            <begin position="186"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="326" mass="36336" checksum="357BFED5953D8240" modified="2008-01-15" version="1">MRNAQAQSESVDHIEHDEDADLVRRVSVRLFWDELAKVLQRAGTEWAGLAAQICAFGPKHVGPNLLLDPQQILRRSLMQRIQAQDSKSQLAAGMQHISLSSTGAEDSTPRLEREWCDAIEAGFQLASGAGPLCAESMQGVAFFVQNVRVDQDALGDARAKSSQMASMVISSVRESCRQGMLDWSPRLLLAMYSCDIQAAPEVQGKVHAVLSRRRGRIVSEEIKEGTLFFTIGALLPVVESFGFAEEIRKRTSGAANPQLFFAGFQLFDEDPLWVPRTEEELEDLGEKGDRENIAKRYMDMVRKRKGLKTDKRIVASAEKQRTLKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXE9</accession>
    <name>A8PXE9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731242.1">
        <property type="nucleotide sequence ID" value="XM_001731190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXE9"/>
    <dbReference type="STRING" id="425265.A8PXE9"/>
    <dbReference type="GeneID" id="5855549"/>
    <dbReference type="KEGG" id="mgl:MGL_1425"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1425"/>
    <dbReference type="InParanoid" id="A8PXE9"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="465" mass="51675" checksum="FEACB79340116214" modified="2008-01-15" version="1">MANTMALRQMERDILLGPYHRDVEKSKKTNDASRPGHGTFLQSSASSICWGTSFVEALEEKYGSSQCLDTLRTASLVGPSTRTMHDASCVYVSHAFPGHADEGVMLCPALQELDMSRSLLSSWDQVARITRTLPLNRLTLQHVRLQKPELAQVSLAFEQLTHLSLGDTATDWAQILVLGSVMPKLTSLELAHNEIDTLATADTAAYLPFVQILNLEGNRLSSWEDIVKALSPLPRLQKLILTDNPITHINFSSQKFPVLSDVHLTGSALTFDDLQVLESCLDSPTWSLVFHPSDVDERQARIQAVSRLAKLVSFNHTPITQEERIDAERYYISRPKPNDPRYDALVEKHGHPPTCSLTPAVSSAKMTSSLQDKLIQLYYIHSSSVPTSSDLVHLQEKASIEAFLKTAPCRLVHRRLVALLRACQSANMYAVMAASPEPIVLPLDDPMRDLAWYGLADYDLIVLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXI7</accession>
    <name>A8PXI7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731273.1">
        <property type="nucleotide sequence ID" value="XM_001731221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXI7"/>
    <dbReference type="STRING" id="425265.A8PXI7"/>
    <dbReference type="GeneID" id="5855580"/>
    <dbReference type="KEGG" id="mgl:MGL_1456"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1456"/>
    <dbReference type="InParanoid" id="A8PXI7"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="41" mass="4501" checksum="738A5842CBA55BA4" modified="2008-01-15" version="1">MPSLDTVYLEGNPAQRSEGASYRRKVQLALPQIAQLDATIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXK9</accession>
    <name>A8PXK9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731288.1">
        <property type="nucleotide sequence ID" value="XM_001731236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXK9"/>
    <dbReference type="GeneID" id="5855595"/>
    <dbReference type="KEGG" id="mgl:MGL_1471"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1471"/>
    <dbReference type="InParanoid" id="A8PXK9"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="55" mass="6421" checksum="BBAD886BAA98B13A" modified="2008-01-15" version="1">MSVEEALAMPEFGVQQYIAAQVQYSPKAVERLVRIPEQDGNPVFDRNEWIYEHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXP3</accession>
    <name>A8PXP3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731311.1">
        <property type="nucleotide sequence ID" value="XM_001731259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXP3"/>
    <dbReference type="FunCoup" id="A8PXP3">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXP3"/>
    <dbReference type="GeneID" id="5855618"/>
    <dbReference type="KEGG" id="mgl:MGL_1494"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1494"/>
    <dbReference type="InParanoid" id="A8PXP3"/>
    <dbReference type="OMA" id="LFTYPCP"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="86" mass="9710" checksum="F6BA0508EF3053A9" modified="2008-01-15" version="1">MPLSYYDEIELEDMDYDESKQVFHYPCPCGDRFEISLLQLRAEEDVARCPSCTLIIRVIYDPLDLEDDQGTLPCMDTGAAQVSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY34</accession>
    <name>A8PY34_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731399.1">
        <property type="nucleotide sequence ID" value="XM_001731347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY34"/>
    <dbReference type="FunCoup" id="A8PY34">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY34"/>
    <dbReference type="GeneID" id="5855706"/>
    <dbReference type="KEGG" id="mgl:MGL_1582"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1582"/>
    <dbReference type="InParanoid" id="A8PY34"/>
    <dbReference type="OMA" id="IMARVEP"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000002">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000571">
        <property type="entry name" value="Guanine nucleotide-binding protein-like NSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="42"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="612" mass="66489" checksum="3C6C8345CE25BFC7" modified="2008-01-15" version="1">MMNDTHEAEAVDMAVEAKQASRDARARLAQMTDKDHSIKSYMKELRKVLEHADVLLEVLDVRDPLGCRAYAVEEEAQRLGKRIVLILNKIDLVPRSNAQAWLEYLRHEFPTLPFKASTQQQRSNLAQSQNISWKSTGSGDKAEAQWAGGAESAGTRAILQLIKNYSRNLNLKTSITVGTIGAPNVGKSSLINSLKRSRVCGVASTPGHTKVVQGIMLDRHVRLLDSPGIVFSDANASPGATAAEITAAAEAAMLRNVLKVESVEDPVEPVQAILNRIEPKYLADVYDIPPITSRDAQDFLLRVAYQKGRLGRGALPDLDATARSVLHDWNTGKIKYHTEPPAKHPDLLRRRSSTQSTRQPGALSSSSDDGSAAILTSFSEPFDLAGLLGEADADVLGGDGAYSPPASESQVQEQQETPTQAMHDEVVADVTDSTLGKRGRLDSDDESDDDNVDDSRAHRKPNAWSLLDVQGNDDDDDDDADDDDDDNGMDLGFHANQAKTLSSAETKSKQGKASNDRPMFSAAEIQDMAPARGKERRKARKLKKRRAGDALVDQIDTLMDFGDAHDQSADEIEADGHSGSADMIDVRGAERVISEPSVDAANAQDVSEEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY60</accession>
    <name>A8PY60_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_1597</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731414.1">
        <property type="nucleotide sequence ID" value="XM_001731362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY60"/>
    <dbReference type="FunCoup" id="A8PY60">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY60"/>
    <dbReference type="GeneID" id="5855721"/>
    <dbReference type="KEGG" id="mgl:MGL_1597"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1597"/>
    <dbReference type="InParanoid" id="A8PY60"/>
    <dbReference type="OMA" id="VVTVFWD"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="39"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP44200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="372" mass="39877" checksum="B6D8E0AF43E95DDC" modified="2008-01-15" version="1">MASVLRATVPRVLPRTVRAFSSAAKVSATVGPVSGFCGAVGNTPLIRINSLSNETGCEIYGKAEFMAPGGSVKDRAALYIVLDAEKKGLIKPGGTVVEGTAGNTGIGLAHVCRARGYKCVIYMPNTQSDEKINLLRMLGAEVYPVPAVPFADPQNYNHQAARHAEKLENAVWTNQFDNIANREAHILTTGPEIWAQTRETGLDGFICATGTGGTLAGTTRYLKDVSRGQVQCWLADPPGSVLHSYVQTKGERMERTGNGSITEGIGQGRLTSNMSPDISLIDNSLHIEDEASIAMVFRMLDEEGLYIGASSALNIVAAARMAEKLGKGSKVVTIICDGAARYQTRLFSRQWLESKSLLSAVPSHLHKYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY72</accession>
    <name>A8PY72_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S13-like H2TH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731421.1">
        <property type="nucleotide sequence ID" value="XM_001731369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY72"/>
    <dbReference type="FunCoup" id="A8PY72">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY72"/>
    <dbReference type="GeneID" id="5855728"/>
    <dbReference type="KEGG" id="mgl:MGL_1604"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1604"/>
    <dbReference type="InParanoid" id="A8PY72"/>
    <dbReference type="OMA" id="CARVQIH"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21072" checksum="3DC852C9042C37CB" modified="2008-01-15" version="1">MYLLGTYLPDHKLVRIALTNFYGISYDTARRLCARIQVHERATVSSLTESQITDLSAYLSSPGMIPAASPTPTRASLHGSTPKPPMPENPAELPPSQRPKASMDPLRSIVLESDLRREVLANIAHHRSIGSYVGKRHAGGFPVRGQRTQRNALTARRLNRLERRQYSTTSPSATLFDILHPLARARFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYD2</accession>
    <name>A8PYD2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731456.1">
        <property type="nucleotide sequence ID" value="XM_001731404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYD2"/>
    <dbReference type="FunCoup" id="A8PYD2">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYD2"/>
    <dbReference type="GeneID" id="5855763"/>
    <dbReference type="KEGG" id="mgl:MGL_1639"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1639"/>
    <dbReference type="InParanoid" id="A8PYD2"/>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="83" mass="9645" checksum="0C665BD28D14220E" modified="2008-01-15" version="1">MIIPVRCFSCGKVIGDKWDAYLALLIEGRTEGEALTELQLHRYCCRRMVLTHVDLIERLLHYNNVAPLCFYHAHFRFPSPPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ70</accession>
    <name>A8PZ70_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730894.1">
        <property type="nucleotide sequence ID" value="XM_001730842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ70"/>
    <dbReference type="STRING" id="425265.A8PZ70"/>
    <dbReference type="GeneID" id="5855201"/>
    <dbReference type="KEGG" id="mgl:MGL_1893"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1893"/>
    <dbReference type="InParanoid" id="A8PZ70"/>
    <dbReference type="OMA" id="SWKPAYL"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="84"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="304"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="454" mass="50903" checksum="0E85C8EC5172F8F7" modified="2008-01-15" version="1">MVITPSRSDANLSQSHNLENRVGATSSFMTECGGDSSRDKGSLVAPPIQHVPVIDTSIDVEGDAEDDEDEAYKHEIPTELLNEQVVHAGFLLKRGDKHKMWKRRWVVLRVSQMAMYKNEKEYRLVNVLNVSQMHSIASLEMKRFGTVICIVTPDRTWYFRARDQHDTSAWLNALHHVQGHTPEQHLVAAPSVYDAASHTPGIAIKDSAGHTDDYHPHDRHRLYNQHTNHPHVATHATHPEQSQPQPHPPGECARPVPTTTGGHLLSSSDDDNEADDTIAFGLGGEAAAGVATPSPAPVEEDRSRVIAQGYALKQSSRRKQWRKRWFVLTLDALYYTRSHMDTRAHRSIPTTCILDTMECDVPSVGSPTLSLSPGTLGRLGFGSNIPEMRCRAPMPGVHQRDVYAHEVQHRVSSYSFQIVTTERTFVLCVPTEDDEIRWLSALQTLLNRQRRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZN2</accession>
    <name>A8PZN2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Conserved oligomeric Golgi complex subunit 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730935.1">
        <property type="nucleotide sequence ID" value="XM_001730883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZN2"/>
    <dbReference type="STRING" id="425265.A8PZN2"/>
    <dbReference type="GeneID" id="5855242"/>
    <dbReference type="KEGG" id="mgl:MGL_1934"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1934"/>
    <dbReference type="InParanoid" id="A8PZN2"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="1">
        <location>
            <begin position="90"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="409" mass="46633" checksum="F5BBDC9F499250EA" modified="2008-01-15" version="1">MMNSSAAPLSLDEWYVQYAPLSDTQRMSVSRLSAWVSADEPGAPTEATQAIDESEGEQDGLNLNFSCWLHSVTKKHEDASRTTFANELGMLRTSMNEIDERLDDVHRAQERIVQLRTGLEYVQESSSELMHHASALLNEQVDLESLHEQIMLRLQYFSVLPQVTAILSETDAHVETAEFLSTIERLCVALQFMECHPRYKDTQVFRIRIENALQRAMSLVKQAFQREGNVCMSEAHSQVQALAKEALDAGTHTSMNPTAPSMHQAIYASFASLQPKFQAFFEHLRQLANQKAEFRDIQHEFDSIWIRWRTSLIHDAYAMCLNAFCDNVPLEQQLRHATYSAHEYYEHEMQLFLHVNARTPDNAEPVKRISQTVGEQLQAWLSQRIETTPLNVLSEICTIVVSYGGRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q065</accession>
    <name>A8Q065_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730989.1">
        <property type="nucleotide sequence ID" value="XM_001730937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q065"/>
    <dbReference type="FunCoup" id="A8Q065">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q065"/>
    <dbReference type="GeneID" id="5855296"/>
    <dbReference type="KEGG" id="mgl:MGL_1988"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1988"/>
    <dbReference type="InParanoid" id="A8Q065"/>
    <dbReference type="OMA" id="YGYDMPV"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000055">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="276" mass="30278" checksum="336CCEB07827BA34" modified="2008-01-15" version="1">MSRSSYDRHLTIFSPEGRLYQVEYAFKAITSAGITAVAVRGKDAVVVATQKKLPDKLIDASTVTHIFAITPNIGCVVTGRTPDARAQVQRARSEAAEFKYKYGYPITPDLLAKRMANINQVYTQKAAMRPLGLSMILIGLDDERGQEPQIFKLDPAGHYVGYRATASGTKQTEAMSFLEKQFKRVPTAMAPDAALAEAEKLVGELSRDEILDMAVNTLHTVLAQELKPSEIEIGIVGGPAVHDPSASAREVESQQRFSMLSEAEIVQILERLAERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q089</accession>
    <name>A8Q089_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730999.1">
        <property type="nucleotide sequence ID" value="XM_001730947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q089"/>
    <dbReference type="STRING" id="425265.A8Q089"/>
    <dbReference type="GeneID" id="5855306"/>
    <dbReference type="KEGG" id="mgl:MGL_1998"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1998"/>
    <dbReference type="InParanoid" id="A8Q089"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="179"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="406" mass="45746" checksum="DAD586DBC68033C6" modified="2008-01-15" version="1">MSQRVSRPVARYRPGQAPVHTEKDSSSSSSSDEEAAPRVQQRVSLPSRVTSAPRPPPSSAATWIHPPPQVPQGPQLELSEYETDTDDESDDREGESRNHGPNPSLKLASFSEAQKPPRTPMTSASSRLAPPPRLNKQALPPSSVTLGEVSAAGAHENSIKAESGSDSESESGTESESPSESDEMPAPLPKPIFVSKRDRVTHASGPTEHVESTRRGVEEKRIHRERAHELAAQRIVRDMQEREHEDSQCEVDDTDGMDPEAEFAAWRIRELARLERIRQAERMRESQEAEKARRRAMPEHERLAEDLAHARHTRAAKQRGHQGFMQKYYHKGAFFQDMDILQRDYTHSTVDAVDKSQLPHIMQKRNFGKRSQSKWTHLAGEDTTRQKEGEPDLRMQGAYLAQRHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0C6</accession>
    <name>A8Q0C6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731014.1">
        <property type="nucleotide sequence ID" value="XM_001730962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0C6"/>
    <dbReference type="FunCoup" id="A8Q0C6">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0C6"/>
    <dbReference type="GeneID" id="5855321"/>
    <dbReference type="KEGG" id="mgl:MGL_2013"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2013"/>
    <dbReference type="InParanoid" id="A8Q0C6"/>
    <dbReference type="OMA" id="AVYQEHK"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="127" mass="14601" checksum="CFA89B16DF7BF956" modified="2008-01-15" version="1">MKSAFKKEHTFDVEQRIEESQRIRQQYPDRVPVICEKAEKTDIPNISKKKYLVPGDLTVGQFVYVIRKRIKLSPDKAIFIFVESVLPATSASMNDIYAEYKDEDGFLYLCYSGENTFGHLAASRDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0N8</accession>
    <name>A8Q0N8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731061.1">
        <property type="nucleotide sequence ID" value="XM_001731009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0N8"/>
    <dbReference type="FunCoup" id="A8Q0N8">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0N8"/>
    <dbReference type="GeneID" id="5855368"/>
    <dbReference type="KEGG" id="mgl:MGL_2060"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2060"/>
    <dbReference type="InParanoid" id="A8Q0N8"/>
    <dbReference type="OMA" id="QRTEYNK"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38965" checksum="7CA9D448E5BD7766" modified="2008-01-15" version="1">MGYKAGMTHIVRDLDRPGSKYHKREIVEATTVIETPPMVVVGMVGYVETPRGLRSLTTVWAEHLSDEVKRRFYKNWYRSKKKAFTKYAKKHSENNGQSIARELERIRKYCSVVRVLAHTQLRNTSLKQKKAHLMEIQVNGGSVSEKVDFANNLFEKTVDVNSLFTQDELVDVIGVTKGKGYEGVTARWGITKLPRKTHKGLRKVACIGAWHPANVMFTVARSGQDGYHHRTELNKKIYRIGNGADKASGATEFDTTQKSITPMGGFPHYGIVKNDFLMIKGSCPGVKKRVLTIRKSQKIHTSREDVEKVTLKFIDTSSKFGHGNYQTGAERDAFEGPKKPPAVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0S7</accession>
    <name>A8Q0S7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731077.1">
        <property type="nucleotide sequence ID" value="XM_001731025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0S7"/>
    <dbReference type="GeneID" id="5855384"/>
    <dbReference type="KEGG" id="mgl:MGL_2076"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2076"/>
    <dbReference type="InParanoid" id="A8Q0S7"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="36" mass="4292" checksum="28DC13E984F65655" modified="2008-01-15" version="1">MNLSRKLLFFLARTCYSLSLLSRYDKLDSIIFNHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0T2</accession>
    <name>A8Q0T2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731079.1">
        <property type="nucleotide sequence ID" value="XM_001731027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0T2"/>
    <dbReference type="FunCoup" id="A8Q0T2">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0T2"/>
    <dbReference type="GeneID" id="5855386"/>
    <dbReference type="KEGG" id="mgl:MGL_2078"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2078"/>
    <dbReference type="InParanoid" id="A8Q0T2"/>
    <dbReference type="OMA" id="PIMDEPR"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="421"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="487" mass="52976" checksum="D15CE2A2672D2E81" modified="2008-01-15" version="1">MEGDCRRAKKILNTFCPVGTQHGLDKVIPRSVLRKAKGFAIFTIFRVGFLMSARVGMGVVVAKLPSGEWSPPASIGIGGLGGGFNAGAEMVDFLVVLNSRAAVRSFMTAGSLQLGGNLSLAVGPLGRTGEASAAMNADMQFSAMYSYSVSRGLYGGITIEGTVLIERKDTNEKVYGGSVTPMQILSGQVEMPQFAIPLITRIEEATGKVPFADEDSSVIGNEDYNDLGYDAHFDDLYAPPQSIRRRTAPNAPSPVSYRQRLSGSPMDDLDEQLQSASLSGRSPSPPPPSRWRPPGVHHRSDPCTARGPSTYDAPTFSTSSKYRVDSFGRGSSSHSRTRTQDSLAHAAENPFSDMNAVLDDDIPHTQRYSQLHFQSHSIELPSDNYALLDVDSTQMPTPASCLRDPDPVQTHPIDLVDPSLLDGDLVVATHDYKAQRDSDLSFQRGDLIRVTRRTDKLDDWWMGELVANYREGPPESGEFPSNYTEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q108</accession>
    <name>A8Q108_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731110.1">
        <property type="nucleotide sequence ID" value="XM_001731058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q108"/>
    <dbReference type="FunCoup" id="A8Q108">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q108"/>
    <dbReference type="GeneID" id="5855417"/>
    <dbReference type="KEGG" id="mgl:MGL_2109"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2109"/>
    <dbReference type="InParanoid" id="A8Q108"/>
    <dbReference type="OMA" id="RAIVMQW"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF14">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25833" checksum="D73C16BCB18359BF" modified="2008-01-15" version="1">MWGTNPIKVGAFLEALGLEYDMKFVELGSSDKATGVKGEDYLNVCENGRTPTLIDHKRNDFTVWESGAILDYVATVYDTEHKFHGKTPEERALVMQWLFFQVSGHSPVQGNLFFSKMFWPSTFNENAPENVIKRFRTELDRVFRVYERRLKHQASMYGEDRAFLALDRPTIADFSALGWFVMLPDYASKIDIDLAEYETLAKYIDRLRNLPSSKAVMARFESSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1G7</accession>
    <name>A8Q1G7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730786.1">
        <property type="nucleotide sequence ID" value="XM_001730734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1G7"/>
    <dbReference type="STRING" id="425265.A8Q1G7"/>
    <dbReference type="GeneID" id="5855093"/>
    <dbReference type="KEGG" id="mgl:MGL_1785"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1785"/>
    <dbReference type="InParanoid" id="A8Q1G7"/>
    <dbReference type="OMA" id="HIFVCTH"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55055" checksum="754DD196A49F3DEB" modified="2008-01-15" version="1">MATAAISCSLPAYAQRIPCRLVRAPAPARLIGAWQRQRLYSSRAWPGSFACDAAPALDEHGHIPSAPYDAEPLTGTLPHTDAHLVLHPAQYSRPPTTWPSHVESSCALLSELASRTREHGSLAGFRVNLSSGDAALAEPPSGAWDPSRSTAMRMPPNHAQEDEMFWLYAYTTSGRYVRWPEPISLRTLPSGTELRTQLQAMWSRAHDTLESHIYVCTHGMRDCRCGVAGTAVYDALQRAVTNHTAQCAQDGAKPARTIRVFPISHVGGHKWAACALVYPHGDWYGNLRVSDVPLLLRTALAPSSSRHDLDDLRERLVVWPRWRGRLGMSQSEQRDHRDVWGPPIVHTAHITPARRSRSHSRSPTPSPPAAVDTRTTVPLRFHAHDGTWYNVDGHIGESLMEVAKRHNLPSIEATCGGELECATCHAYLCDASDGSDPATRGDINCAPSWSAAAVSDEEDDMLEYAPFRKASSRLTCQVRVSQALSDWMQRGGRIELDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q301</accession>
    <name>A8Q301_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730484.1">
        <property type="nucleotide sequence ID" value="XM_001730432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q301"/>
    <dbReference type="STRING" id="425265.A8Q301"/>
    <dbReference type="GeneID" id="5854791"/>
    <dbReference type="KEGG" id="mgl:MGL_2280"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2280"/>
    <dbReference type="InParanoid" id="A8Q301"/>
    <dbReference type="OMA" id="HWATWRD"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="155" mass="17946" checksum="3A4D605D2EEF3FC0" modified="2008-01-15" version="1">MARGSVLAAGTATQYVETPVRPHSSRVRIMLHTATGATELDPERVANQQRFSRDLEFLSALSNPYYLHQLSQQGYFEDEAFLHYLEYLDYFRAPRYVKYLTYPQSLYFLDLLKHEAFRSAVADSAWPHDTAARQMAHWATWRDPVNVSFGSPPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q310</accession>
    <name>A8Q310_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">XRRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730490.1">
        <property type="nucleotide sequence ID" value="XM_001730438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q310"/>
    <dbReference type="STRING" id="425265.A8Q310"/>
    <dbReference type="GeneID" id="5854797"/>
    <dbReference type="KEGG" id="mgl:MGL_2286"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2286"/>
    <dbReference type="InParanoid" id="A8Q310"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="XRRM" evidence="4">
        <location>
            <begin position="16"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="185" mass="19935" checksum="156A31C1A7AB290E" modified="2008-01-15" version="1">MLCTKPDGTIEADKVSFPAQSVLRFTNASKDGNWKDLKDTLSTLHPTLFVEFPAEAVEGVVGFREPVSDEKLREIQDKGITVGGSTVSWERVGEDKARDFYVERANFRASFLLDRREAERHAPRRGGRGGGRGGRGGRGGRGGHGGRGSGHADAAPATGSNEKRKNTDEPPEIGAKRSKTTDQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q325</accession>
    <name>A8Q325_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730500.1">
        <property type="nucleotide sequence ID" value="XM_001730448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q325"/>
    <dbReference type="FunCoup" id="A8Q325">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q325"/>
    <dbReference type="GeneID" id="5854807"/>
    <dbReference type="KEGG" id="mgl:MGL_2296"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2296"/>
    <dbReference type="InParanoid" id="A8Q325"/>
    <dbReference type="OMA" id="IHHAAIM"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000238">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.20, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="690" mass="76281" checksum="5D719190E0AFF7E3" modified="2008-01-15" version="1">MPLSVPEGQIFKATYSGVPVYECIIKDVAVMRRRSDAWLNATQILKVVGLDKSQRTRVLEKEVQKGTHEKVQGGYGKYQGTWIPMDVAIALAEHYHIRELLDPIISFVPSDKSPPPAPKHAIASSGRIKKLPSDLADASTTRVSSDENSSEIFPAEDENGSEGSISPSPSDISSSSRTPSPIGADTQKPPEYQTFADTRHPGMYTPNGRIATTYAPATTYQDHYGMPVQQHTYDELEPQVRYAEIILDYFISETTTVPPLLVNPPPDFDPNMSIDEDEHTALHWACAMGRIRVVKLLLTAGADMFRVNNNGQTALMRAAMFSNNYDLRKFPELFELLHRSILNIDRNDRTVFHHVVDLALSRGKPHASRYYLETMIHRLAEYGEQLADILNFQDDEGETALTMAARARSKRLVKLLLEHGADPKIRNREGKNAEDFIVEDERFRASPSRTTNAPYVPSSNAPHSSEAGQRAAGRSVGLVSTLLHDLADSYDTELSVLERKLTHAQTLLIQIQGEIADSNRIEASLMPKGQSNDDASTLNALENKYTSARQEQANKEAERSWKSMHEQVLQARPDLSLGDAPTANEDVQRLCAKPKSESLRTELETLRAQANDALSQYQALELRHFRTLCDEGADRTMAMYRRLIAAGCGGIATKEVDAVVGVLSDLLSEGDSAGAATKGTEPDSVGPMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3G5</accession>
    <name>A8Q3G5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730597.1">
        <property type="nucleotide sequence ID" value="XM_001730545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3G5"/>
    <dbReference type="GeneID" id="5854904"/>
    <dbReference type="KEGG" id="mgl:MGL_2393"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2393"/>
    <dbReference type="InParanoid" id="A8Q3G5"/>
    <dbReference type="OMA" id="QWGRTAS"/>
    <dbReference type="OrthoDB" id="3353747at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="199" mass="21149" checksum="C1F2E0934A9EA98D" modified="2008-01-15" version="1">MFGGPLSAMASSDGPTFSNAQSTWQHVQQTYPQWGRTASVPYGALRGTPSNTTMPAASSQAMERSVTESHTSPSSLVSDTVESGTLSMKRGISEDDSDAILAGAFDDDDGAGAIDRNMGLSCSSFPMAPPSPPPAQAQPTTYTQVSSRPVRPLPSRQGMFRPIKSMPVAKTQDLTMDDDNSEPFQRVDFSAYAAHPHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3K5</accession>
    <name>A8Q3K5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 11">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 11">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2432</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 11"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730636.1">
        <property type="nucleotide sequence ID" value="XM_001730584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3K5"/>
    <dbReference type="STRING" id="425265.A8Q3K5"/>
    <dbReference type="GeneID" id="5854943"/>
    <dbReference type="KEGG" id="mgl:MGL_2432"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2432"/>
    <dbReference type="InParanoid" id="A8Q3K5"/>
    <dbReference type="OMA" id="KDYHHQM"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008350">
        <property type="entry name" value="MAPK_ERK3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01771">
        <property type="entry name" value="ERK3ERK4MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="80"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="427" mass="48435" checksum="F726CFFBD981BEE4" modified="2008-01-15" version="1">MAAVQAREDPTRMESRRYVSFVLRTAGRKSSKSILTYTSNRAATASSKHVRELAHHAEMRKEDRRAAAIRKAREDIGHHYSIYSVVGEGGYGIVFSAVNRHTGSRVAVKRVSPFEHHLLAIRTLRELRLLRYFQEYSGCENIIKLLDVVIPGDRCSFQDIYFVQEIMDTDLYRVVRTQSLSYDHAQYFTYQILRGLKPIHAAGVLHRDIKPSNLLVNANCDLKICDFGLARNTTQASPHGRDLQLTEYVATRWYRAPEIMLSSKTYTKAVDIWSVGCTLFEMLTGEPLFPGKDYHHQMLLILDVLGTASVDSIASQCSPRALDYVRALPWCSGRSWTSLLPNVQSDAIDFLSRAVTMDPNARMTVDECLAHPFVAPYHDPSDEPGAPPLEQHACEYDVPPTLNTDVYRQALWDDNQIYARHSLRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3M4</accession>
    <name>A8Q3M4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2448</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730652.1">
        <property type="nucleotide sequence ID" value="XM_001730600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3M4"/>
    <dbReference type="STRING" id="425265.A8Q3M4"/>
    <dbReference type="GeneID" id="5854959"/>
    <dbReference type="KEGG" id="mgl:MGL_2448"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2448"/>
    <dbReference type="InParanoid" id="A8Q3M4"/>
    <dbReference type="OMA" id="EYRGWTA"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="9">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="303"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="395"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="430"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="472"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="630" mass="70309" checksum="5AD0E76491DA6A98" modified="2008-01-15" version="1">MFMEANQTKRILEEANDQVVVDRQHRRMTPHLMDTNARLTSSMTNIGSSVLADPTASESLTNSVIMPWASASIKNDIVRIIAQWLADEGFGATRQALLEEASLKVRGHDDEVNERHKLRTFLLEGNWTEVEKLSSKPFLKSHKPFLYAIFRQQFLEFIENREFQKAFTFLMKRLKPLEHYQPHAAEFGDLCYLLSAKSVTDAPSFRMWEGIQPGREALVADFASFLEPGRLDREQLLPEESDPVTTPPNNVFVPPHRLLTLLHQAMAYQVEFARYQKRTVPVVSTLLHDYSGFVVPNRCRMTLRGHTQNVKCVRFVGDDGGKIVSGSSDCTVRLWDTATGICDAVLEGHGSRIWDVDASRNGAWVSSASSDATVRLWNVESKLSHLTLRCGFGDVYCCRFSPDEGHIVTGGYDKLVRLFDLASGSAIRMFPGHELGVSSAVFSPQGSLIATGAKDTSVRFWDTLSGVCVRTLPGHLGEVTSVEMSDDGRQLLTSSKDNSHRLWDMRMLRPLQRFKGHQNTSKNFIRCAFAHPSLIVSGSEDGLVCMWGQESPLTLQTLEGHGIESTTRADGSTTVPFAASESVFAQSHHGRKQVVVYSAVWNKVQGLLASCADDGTVRLWDWTPPHETHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3N6</accession>
    <name>A8Q3N6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase DBP8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730662.1">
        <property type="nucleotide sequence ID" value="XM_001730610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3N6"/>
    <dbReference type="FunCoup" id="A8Q3N6">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3N6"/>
    <dbReference type="GeneID" id="5854969"/>
    <dbReference type="KEGG" id="mgl:MGL_2458"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2458"/>
    <dbReference type="InParanoid" id="A8Q3N6"/>
    <dbReference type="OMA" id="IMIFTDT"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="15"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="243"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50230" checksum="A13A403C4A3DC376" modified="2008-01-15" version="1">MVAINVPTPIQSACIPAILEGRDVIGGAETGSGKTLAFALPILHNLFKDTVGGYAVILTPTRELGVQLHEQFLAVGQGSRMGLKCALVLGGMDMTRQANELGEQRPHIIVATPGRLVDLLSSGAAQEWGLERCKFVVLDEADRLLSPTFAPALAYLFSILPPAHMRQTLLFTATLTPEIERLTEKTPEPGKLPPLLRKIDMDTSTPDSLIQQYTLVPSHMREPYLVYLLNNPPCENKVKVHAELSDVYRTHKAPKIKGGEEPSFPLTIIFVSRCKNAELLSRMLTELGIPNVSLHSMLPQFTRLHNLQMFRARRVPILISTDVGSRGLDVPDVELVVNWDVPAAWEDYIHRVGRTARKGRRGWAVSFVTEHDVELIQAIEAKIHKRLDELELPEAQVLDRLSHISAAKRVASMELHDEKFGEQRERNKRKAKIAQGGKRSKHKLSASSTNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3Z8</accession>
    <name>A8Q3Z8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import receptor subunit TOM40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730101.1">
        <property type="nucleotide sequence ID" value="XM_001730049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3Z8"/>
    <dbReference type="FunCoup" id="A8Q3Z8">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3Z8"/>
    <dbReference type="GeneID" id="5854403"/>
    <dbReference type="KEGG" id="mgl:MGL_2483"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2483"/>
    <dbReference type="InParanoid" id="A8Q3Z8"/>
    <dbReference type="OMA" id="TRFNYRW"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="39799" checksum="DD4584679640070B" modified="2008-01-15" version="1">MATPVAEVPVVPTPQVNVVVEKPSAEKTLSNFFTMMDPLVRPVADTFSKMREIRRSLALPNLGTVEKMQNEVKMVQTTNFQFEGARADLTKALNMNPIFQVTHAFTLGAAGKNAYNFGAVYGDENRFYQAGLDDAGNVTMRLNRQWLPGHISKIQAQLAPAGGQSFVQLEHDFQGSDYSINFKALNPSPTNMTGIYVGNYLQTLTPRFALGAEAVYQHPSPEIEEASIGYMAKWVGPAKEWIATAQWQPQGVGQLTYWHQLSEQVDVASDLQMIMLPQRRDAQASLSARYSFRMSSLRAQIDSLGKLTSVYEARISPAFAFTFSGELDHLSGGAKVGLGVSIESGVEPVDPMAMPSMPPSVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4J9</accession>
    <name>A8Q4J9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730169.1">
        <property type="nucleotide sequence ID" value="XM_001730117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4J9"/>
    <dbReference type="GeneID" id="5854476"/>
    <dbReference type="KEGG" id="mgl:MGL_2551"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2551"/>
    <dbReference type="InParanoid" id="A8Q4J9"/>
    <dbReference type="OMA" id="GFEYWRE"/>
    <dbReference type="OrthoDB" id="3342809at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37211">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37211:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="497" mass="56181" checksum="1BA8EF361500D62B" modified="2008-01-15" version="1">MSHEARHQGYSGGATQDEAHVPIAATADVLRCYEEAVQEPLVECVNLDGLYTNSQDKHSDRLDAEILREDFCSTAIIANTWLTLRPQNRSQGVDIDLDALRDTQKKLGGRRVQLLQSPTFAHQTHTVELPAESMEPRTTMAAANEDTYVTSWAEGQGSERLDRRLAKRKDRKPKKTAGQGKCDGPTAAAPEPRMVLLHGDVLELPVPPTMGGTSLEQPDIVASLNYAMAYFHDRSTLIRYLRSVAQSLRPKTGVFITDMFGGPPTGEAYEDQDELWTRFWDEPGFLRTAGDAAQFQLPTRAPDTDDDDLVVRPAPSDTERGTRAEWPRGKLKMVRTGTAHGGFEYWREDGPIDYTTNRFRMSLSFRFADHSWLRDVFSYDFRIWSLKEVRFSAEKPAESCALLQFTLFTDALSRTYQLTEAMEEAGFAFVRVLVLPRNDIDQQDVSDTDSDISDEIATMFLRTEKEEAQRRRFHTVQPGEKVFSTRSFATYIVGRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4M9</accession>
    <name>A8Q4M9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730198.1">
        <property type="nucleotide sequence ID" value="XM_001730146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4M9"/>
    <dbReference type="STRING" id="425265.A8Q4M9"/>
    <dbReference type="GeneID" id="5854505"/>
    <dbReference type="KEGG" id="mgl:MGL_2580"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2580"/>
    <dbReference type="InParanoid" id="A8Q4M9"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="289" mass="31112" checksum="BAE53C63149D572E" modified="2008-01-15" version="1">MILSYVYLCLYSPFFPSLQKGPYPPPQPQVKSLPEAADQLSVSSVPSDDAILASQTQSIRLEDLLGGKDAKDARDSDSSSSGVPVFTEQDRTGASILNALFREAASHANPEELGSFQRNPSAQNPQSSEYVAPSDKDASGHASSEQNTAPSFTSEPSTDQRASAPSSGSATDEGSLSMGKSIDLNDLFGTSVQSHPDPTADIDPLEFQAVDDLHNSKPTASPPTAEQLPPIQSASKTHRPLQDAVPPEYVVERLPYERLTRAEFVQKLIVLLCVRCRHTTCCRNKIKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4P3</accession>
    <name>A8Q4P3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730212.1">
        <property type="nucleotide sequence ID" value="XM_001730160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4P3"/>
    <dbReference type="STRING" id="425265.A8Q4P3"/>
    <dbReference type="GeneID" id="5854517"/>
    <dbReference type="KEGG" id="mgl:MGL_2594"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2594"/>
    <dbReference type="InParanoid" id="A8Q4P3"/>
    <dbReference type="OMA" id="EHYLLCY"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="450"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="685"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="851"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1185"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134530" checksum="DE042724E636D9A9" modified="2008-01-15" version="1">MNPFVRTEHALASSPSSTETSSIDALVDEIQQALGTSTSSISSNALASRSSSISSVRRRPLPQTPHPNEKTRHSFSVPSPPQSSFSRIPRPQTAQHISMEETSISTPPLSPRATVKNAYSLATAQAHAEAIAKAANPSAAAAPTAPDDFAAVASSPQRIPLDVRPEGSCSQRRDSQSSQSVWEQIQRRSFSRRDSQDSILPEYSHHTDSHAYAHVMSLQGTCVDLSSLSQVAHLLSSIIERKPLIKGSVVYPLSFTGRTLITTLASMITQYVQVSPRLHVETGMLDPVAQRIALDIARTLKTQLFIHEADWEEHEITNDVAGVYMLYSDSLSGNKESSHASTLRGVSTHLFVRSDAVHVALSATAAVACASVAERDLPSGILTPLTQCYSPTCLWSNGRACYSPSCPRRGRGFPSMIQDHEQPIETVGAKAWVELMPKDIVLTLPREEVKRQNAIHEFVQKEEVFLHDLQLLRMFADRLRSLANPMQPGLPGDAPLVGAALDVFIHEVFGNLDQLLPLIAQFVDELHERQREQGPVVQTIGDVVTRAALDWSCEYTAYVAHYPAALGRLKSEAESNARMQRFIDDCRRHPAAARLPLDTFLFRPPARLQRYHLHLESVLKYTSEYSDDRDALKLAIEVLDEQCLIAQSQVKQTEDHLQVRDYARVLATKRYDDNVDMDLTDPRRQLVHHSRVFRRPDNFEFEWTELVAILFDNYFVLAKRKPNLDCSNASSSLRTKLVINRKPIPTFCLDMSGFDMVPVSRSSVNRYLLPSQVNEMFPFVVTHRFHTNQQPMTLYATSSEERDKWRTALQVLRCDRLPPLYNQCDLSGTAFSTKLEPSETYAFVKDAPWTRSHVTCATTWLWRDHIKLLAIGTTDGVWIGRYAEPRTLRKVLHMKGVMQCAVLTPYRRFLVLADKTLIAYDLEALVPSGQAVPSVAPIRLDGARDVSFFSLGYVWGALHLVYAKRKTTETSVRILALQTSTKSDSSGHASLKGFHLVHKFYVYPEATQIQCISDGFIVSAPRAVYTYRLGSTSLTPLLAQRQRDERAHSLLKQWEGSQPLGVFHVPELNCWLACFDRGACFVNEAGLIVCPDRSFLWEVTMDSAAYYKGHVFACSPTLLEVHEAKSGRLVHLSEGHHMRLLLHTSTDQTLPIPPILLETIPTATPLVDVQRVVALHRLAENKASQVQQDIPGDSAEEGRSTSNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4W9</accession>
    <name>A8Q4W9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730278.1">
        <property type="nucleotide sequence ID" value="XM_001730226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4W9"/>
    <dbReference type="GeneID" id="5854583"/>
    <dbReference type="KEGG" id="mgl:MGL_2660"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2660"/>
    <dbReference type="InParanoid" id="A8Q4W9"/>
    <dbReference type="OMA" id="TVRDYCE"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF25">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725470" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14789" checksum="EE799957EBFB8AE3" modified="2008-01-15" version="1">MKFSVVFSLASLLAACAVTAAPAERAHEAKARVNLENGIKKRGSGKLTWYAGGMLDSPACGGPRPGDDDLIVAVAKDGGYGSCNQKVRLHYQGKHLEATVRDYCEDCQFGHFDGTKGLFRHFAGLEQGILTGVDFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Z8</accession>
    <name>A8Q4Z8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730301.1">
        <property type="nucleotide sequence ID" value="XM_001730249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Z8"/>
    <dbReference type="STRING" id="425265.A8Q4Z8"/>
    <dbReference type="GeneID" id="5854606"/>
    <dbReference type="KEGG" id="mgl:MGL_2683"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2683"/>
    <dbReference type="InParanoid" id="A8Q4Z8"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="115" mass="13384" checksum="13FF73F4C411698F" modified="2008-01-15" version="1">MIDMTGQLWLTETRLTFFPQETNETSNGFHLDYPSIALHAISRFVPEELRGSDMFLLDTCLYCQLDDHPERDDEKENEEENGEVKEMWILVQDSSISTFMHVQDLVNSFSSEFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q568</accession>
    <name>A8Q568_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730355.1">
        <property type="nucleotide sequence ID" value="XM_001730303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q568"/>
    <dbReference type="GeneID" id="5854660"/>
    <dbReference type="KEGG" id="mgl:MGL_2737"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2737"/>
    <dbReference type="InParanoid" id="A8Q568"/>
    <dbReference type="OMA" id="APVTCLW"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="43937" checksum="4250DD9D4C8C755A" modified="2008-01-15" version="1">MFKKLIAKATRDESSSSTGSDSMTSPGFPQVPHGQINHNTTSSGFSQHGQPKPMNQGINTSAPMAHASMGNAATHSHLSMHQSKQHPMWAPPLYAQPTTKHKAPNPSCSTIDVAGLPVNIYGLNHLTPLSAGNVPEVCISIHMHGRTGSAKNEDELVRELWQNTIGERQGLQGTNRVRDFLIATFDQRNHGARMTNKLGQRTWKEGNPMHAVDMYGMIHGTALDVSFLVDMLPAYLFPEGERVVSLFAVTGKSLGGHAAWQVLAHEPRIQVGVPFIGTPDFQKLVAQRTRSSGLENGPPQVPNSLRVLMRQIDPAMQPHSEVTPLNPFFGKKICVCSGEDDKLVRWSFSEEFVKSLVVAPPNSEIARLSLEVFVQPETGHKVTPESMYDNVVIQNFPLTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q599</accession>
    <name>A8Q599_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730378.1">
        <property type="nucleotide sequence ID" value="XM_001730326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q599"/>
    <dbReference type="FunCoup" id="A8Q599">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q599"/>
    <dbReference type="GeneID" id="5854683"/>
    <dbReference type="KEGG" id="mgl:MGL_2760"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2760"/>
    <dbReference type="InParanoid" id="A8Q599"/>
    <dbReference type="OMA" id="RKTWIYE"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="563"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="864"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116346" checksum="CE6B946C6034CB69" modified="2008-01-15" version="1">MVGQTGEDTHQKERPPILDAGRRRHYESVGLLLKAARRQAMTASPKLGITYPPTFAASFWTFPEYRKGAIVLYSRLQEGLDENESVLASIQHRVDSEYAYARALSQGPIVPCISDTMFPGSVDDARTGYLHSNALTSQMVRDVIQSTTAGEAVRHIQVAKRLESMIVEPFGKWAAAHAERVRQSWQLIDASLAEMERQTNEVKKRQSSYEARCWHADEAEDDARFAPGPHVNAVTNGPRNTKDSSPSMKRLSLGQRVASMPETSVIMTATDETGEKEMERPAPASSAREQELQQEANEEPIREGTQESAQQATASDASGVSHAESVASASPSLSEAEAQKLKRRETLRQQFGFKARKPSESSHPSETNETSPHERQKSRFSSYWNLTMERVQDSQALAQVRAAVTGLSEPRHVRLRREAEAAEKAYRDAIVLQDKLRCRAEEILIHEYKLSQKWEFDRAVAIQRVLVAWEQVMRALSGVTDDDKLSRTDRAPMDPAVHIQHLVMNYRTGPFRPVAVVFKPYYHDDLFSVAGMTNGGFGMDLMAAAKGAALSAHTATTLAAPGSSLTMPTLPPVFHALLSALQRSYAERSRWIPKSGVSTDETIHAEKRRIWLYDVPLVKVHELRESLSDFYDQNRGMNVFESTAPDQLLDTIDAPVLAATVKLWLLELNSPLLPYSAWDEVVTIYEAARIRFLSLRKEAGEHEHEHEHRALVEPLVQGLSTVLSRLPKLHLTCLDSLVAHFYKLVKNTPTEEPEDVYLSKLGLAIGRAVLRPNSTLPSLVFSDYPALLLRDLVKHYEVLLPPLMRQKAKESDMKGLSPYRQSPLLRHRSMLVDERIKRSSLQSLGPPPNGMLQRRFTQIESRHSSAPHSRTSSAASRASSVGSNGRVLSLNHLQLDVSPVQAGPAASTKSTASETPTKPSCPSQNHHTPDTTSGTEHPDIMASMTTPTPIRISEAPAPPPKMDSPGTSQVHQARQKLFETASDAATTSAAASTSSLNLASDPDSSLEMPEVAPEPTPSTQASAQPAVPDMHGTTPVRPRQSHVRGPRGPRQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5A2</accession>
    <name>A8Q5A2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730380.1">
        <property type="nucleotide sequence ID" value="XM_001730328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5A2"/>
    <dbReference type="STRING" id="425265.A8Q5A2"/>
    <dbReference type="GeneID" id="5854685"/>
    <dbReference type="KEGG" id="mgl:MGL_2762"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2762"/>
    <dbReference type="InParanoid" id="A8Q5A2"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="155"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="394" mass="42734" checksum="B01138F5EEB77094" modified="2008-01-15" version="1">MSTKLSGTSRLPQDILTTKLSSMTMQEHESHLRVFVSSRVLSLDEPEPALSDIHAHASEPASYSTQTDYMPDPETLSIPDIHLARLSLLATKAPHNPPGSLPRSTPSDHLSDATSSDGEGDERMHASEIPDTLPQGDLYLCGPHESEVRDTQDGGSREAIGHALGACVEAVDRVVAAASVADRIGTEIPRESPYLTSQQLFPIQAGLSDIPPSRWTEHTPAKRAFVLSRPPGHHCSGADPSGFCWVNNAMVAAAHAYRAHSIDRVVILDIDLHHGNGTQALAWRRNADAAASDSQRQARLQSMMRSMQRTGSAASRQAARVADATRTRWERLLHEESLVGPRAQRLFYGSLHDIESFPCENGDAELIRNASVCLGGAHGQWIWNGTYENACATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5B9</accession>
    <name>A8Q5B9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730392.1">
        <property type="nucleotide sequence ID" value="XM_001730340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5B9"/>
    <dbReference type="STRING" id="425265.A8Q5B9"/>
    <dbReference type="GeneID" id="5854697"/>
    <dbReference type="KEGG" id="mgl:MGL_2774"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2774"/>
    <dbReference type="InParanoid" id="A8Q5B9"/>
    <dbReference type="OMA" id="TIMTHPN"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="976" mass="108298" checksum="834D9B354F0AA3C7" modified="2008-01-15" version="1">MTTDPGWPSSTGSSLPAVPTSDDDEADKTLSLEAYEALADDMPSRLRPGLLSEAEKSIGNKHKRALNEIDVRSSPPSKFTCLSTSEPFSLDGDSGWDLDDSQLYSEESLLLTSDAPPSSPVPPHESVRATWTSTQLLIQFLEAVDLDVQDCGLDTPQGTHVMRVDTEVVMQHTSITQLYGLFRRCARDTEKALTSGMMSMDSTPRTLLDIDAHLLSRSLHLLETTMRQQSQRAELRLDLDFASLEAQVRDSVSLLLCAKCCLIVLGFEQLPKFLFSEELLERCLDILKPALEALVLPLVDACSNPVPAGLAFHLIQGSAPASLVAELDIHLHHVCSTMSLLEPLYCLSSVSVPETLMTRCVFLALAPLFAQDRGSMTTTTKKQTNDSSFTHAHVLRPLRLSCLHILRNLFVFYPTQRSWVLSEILISLQQLPDLRHRKRHFRLGGGQRIYVITALLLQLVQAAAYESPASCEQSLAWFVDADVRETQDKPPSQTNHESVHALASSIAAFLVQRVAEDKAGKNSTEMSYAAIVYAIVEDTLALVFLPEWPAAPMLLSCFMRLLVNVLHEAKGALEAKAMALDLLGIVAARIRRAEKQPRPRKSQACPPTMSIICACLDVDALRQTQQAHSSLIQRLSTRNKQDPSILAAIRFHRAQFLYDLALAMRSCKSSGFQNNTQVAANVGDSDKTEDPAIALFQHAIATCAQQMDRNDGPVQVADSHLIMWLVLQSTYFVSFSFLVAPLLQCANSSVLSVRLRALRGLGYVADANADFLDDEHVRETIALHITDTSASVREVCVSLLANYLLYMPAKLPVYLADVSERIMDTAVAVRKRVIRFMRDVYSLRIDYDAKLRIMLRMLRCMHDMDPTVQSLALECMTVMLFSDKTRESPAVLARLFADLCTRIRERPSPLEEFMRRLDKDKTSGDDAQTTSVLALGELVDELISQLFAGDTEPMAMLDQLRVVHISESNTAQRADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5Y4</accession>
    <name>A8Q5Y4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729844.1">
        <property type="nucleotide sequence ID" value="XM_001729792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5Y4"/>
    <dbReference type="GeneID" id="5854151"/>
    <dbReference type="KEGG" id="mgl:MGL_2830"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2830"/>
    <dbReference type="InParanoid" id="A8Q5Y4"/>
    <dbReference type="OMA" id="DGFKPYD"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="124"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="638" mass="68895" checksum="A712F8FFD6439013" modified="2008-01-15" version="1">MPGEANVDDRDDMYMAASGMHRPDASTSFRHMKMACGENALKYNLFGFPIAAFHHAHETYLVPSLLHAAPGGAPAVAIFSTNAYYKYESYFGTPFLADLLKAHNITPIFKSDHPVTDSRRLVNQAAQAHHYGLDALDALRGVTSEPARVLGLDYRVGYIAPRMDADVVLWDRHPLQLGATPVVVYVDGVSQLSQHSSTEHESGADIHGRKPASAPPSADFSYERMRVLNETDAIVQSASPPFPEPIAHTSSVVLTNVSRIFQRKNGTIQTLDLARGSLVYDDGKITCIGARPSDCATHVPAHAHQVDLHGGMILPGLTAYGSTLGLSDIPSETDASSGDDVSMLTHHLRPDLARPVPRAEDSLMFDGHALLRAHASGITTAVSAPAVRGMFGGVSAHFDTGAHSVLDKLSVRASDVALHVSLTPPSSSFSSDGRDNTGYTASMATQLALLRSMISEPTTMEWRRVANGEWPLVVKADAYGTVAKLILLKRAFPQVRLVIDSAGALHGVAAQLAEANIPVLMPAKVWMYSWEQRHRLMGPPLTRDTELGVLLRHGVQVGIRIQEAWEAANLLWDTVWAAQEAHMGSASDILALVTTNIEHMLGLNTSETTDFVAFDRDPFSYGAKVLAIGTARSCELFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6B9</accession>
    <name>A8Q6B9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2915</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729929.1">
        <property type="nucleotide sequence ID" value="XM_001729877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6B9"/>
    <dbReference type="FunCoup" id="A8Q6B9">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6B9"/>
    <dbReference type="GeneID" id="5854236"/>
    <dbReference type="KEGG" id="mgl:MGL_2915"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2915"/>
    <dbReference type="InParanoid" id="A8Q6B9"/>
    <dbReference type="OMA" id="RNWMIFF"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="529" mass="59675" checksum="F9AC0CD63436BE07" modified="2008-01-15" version="1">MSTDSKAPVPKKRTVPAALRPLKYVGIPESVLAWKPRLPSRKWCMFWASLAGLGVVYYDDRRQCKKIMEEYKERVRGLSEQSMHPLEHPRKVLVYTAKYPGDDNYDVGVRFFKRYVKPILVAGAVDYEITSGTSYGNLARELRNRIHQRRRNLAGVEPWTTNTVAGTSLPTTLSPAQYLQRELEGAVVLIGRPALKEWAWALKEGWGTTIPVKPMDFSEKLATELSEDSAFEEITEAATTESDVSTSTQSHERDSEAALPAVPTVPGRGFSVPTQAGLQSMQRRPPFSPFAIPPSAAQSQSVVTEATSELGSKPEPELPPMSPIPAQPPICFVDFTNLVGFSNIPRRIARFFYRREEVRRGAEAGLSIVLGTKNDAREFQAGDRGTIPRDPPQGHDLDWGLEEEAYYPSTFFKTISNIEKWRKSYYEELRKELKASREIARGIREPTKAEKRNMPKSEIELRGQRFDKEEQWRNSEHGFKILDPAAGVEWDESWRGSLRVLVPRSPDEHVPRRTQEAKDSSGEEASVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6G1</accession>
    <name>A8Q6G1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729970.1">
        <property type="nucleotide sequence ID" value="XM_001729918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6G1"/>
    <dbReference type="GeneID" id="5854277"/>
    <dbReference type="KEGG" id="mgl:MGL_2956"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2956"/>
    <dbReference type="InParanoid" id="A8Q6G1"/>
    <dbReference type="OMA" id="TGSMQDQ"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="4">
        <location>
            <begin position="102"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="511" mass="56728" checksum="3DE7725C0001342E" modified="2008-01-15" version="1">MSDPRIASQTLGSVAGLGGSGFVLPSFEDSFERPPRVWPPRTGFWGRTRYLISGMLPGSHRIPRDLPKQSEDGSGVPHLHEMHEQAMPRMYRLLGDTRFGHVRGYRSARKIVVIGVHGWYAQSILKNVIGAPIGTSDKFATMMTESIRRKYAAAGVHLGPEDITTIAMQHDGCVLERADAFYDGILQNSDWVTALRNAEAIFVAAHSQGAIVSTLLLARLLDEGLVESSKTRVCQLTMCGIFQGPFVHIKNSIASSYLSYFETAAARELFEFQSSESDVSRLHRKAYRRILGAGVKCVHVGSVDDNAVPLYSALFSCVAHPSILRAVYVDGVAFPEKDFLIMLIALCVLIRNSGFHDHNLLTLLSASVAGSLYTGMGHTNLYNEPAVYDIATRYMFETYSPHTSGATDVPLVGIPYTSQRWNSYELPWSLRGLLEDRVISHFFMKDIRALIKDYASWNPTNKRLKELHRRLAPMATVHVPTAPSLMKDEPSDEDEEDAFHPAVHKTPPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6M3</accession>
    <name>A8Q6M3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730021.1">
        <property type="nucleotide sequence ID" value="XM_001729969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6M3"/>
    <dbReference type="GeneID" id="5854328"/>
    <dbReference type="KEGG" id="mgl:MGL_3007"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3007"/>
    <dbReference type="InParanoid" id="A8Q6M3"/>
    <dbReference type="OMA" id="KPYMVIF"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7627" checksum="A74BCBFC0C6AC368" modified="2008-01-15" version="1">MQSYMIIFKDEASDPDIEAAMSDVKEAGGQVHRKFDASFLRGFSASLPESYADKLQKAAQGGQHPKMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6S6</accession>
    <name>A8Q6S6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_3045</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730059.1">
        <property type="nucleotide sequence ID" value="XM_001730007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6S6"/>
    <dbReference type="FunCoup" id="A8Q6S6">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6S6"/>
    <dbReference type="GeneID" id="5854366"/>
    <dbReference type="KEGG" id="mgl:MGL_3045"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3045"/>
    <dbReference type="InParanoid" id="A8Q6S6"/>
    <dbReference type="OMA" id="ASYMARY"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="123"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="245"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP42845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="388" mass="42493" checksum="415F6FE253DAAC80" modified="2008-01-15" version="1">MSSQQVLPEGHFLFTSESVGEGHPDKICDQISDAILDACLQQDPNSKVACETAAKTGLILVFGEITSKAQLDYQKIIRDTIKEIGYDSSDKGFDYKTCNVMVAIEQQSPDIAQGLDHGELESHGAGDQGIMFGYASDESPELMPLTVVFAHKLNHALSAARRNGHLPWLLPDTKTQVTIEYKKDGGAVVPVRVDTIVVSTQHTDDVSTEELREKIKSEIIEKVIPSNMLDERTVFHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYTARWIAKSLVHAGLARRALVQLSYAIGVAEPLSIYVDTYGTSSKSDAELVQIIRNNFDLKPGVIVRDLELQRPIYRQTAFGGHFGRSEFSWEQLKPLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6T8</accession>
    <name>A8Q6T8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3052</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730066.1">
        <property type="nucleotide sequence ID" value="XM_001730014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6T8"/>
    <dbReference type="STRING" id="425265.A8Q6T8"/>
    <dbReference type="GeneID" id="5854373"/>
    <dbReference type="KEGG" id="mgl:MGL_3052"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3052"/>
    <dbReference type="InParanoid" id="A8Q6T8"/>
    <dbReference type="OMA" id="DTSLMGM"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="369"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="529" mass="58298" checksum="0B3C68DEF22EACA3" modified="2008-01-15" version="1">MPATTLAGVASARRSYVNPRAWHIIRAPIGYVRSGLRISQGNSFHVTARLPYASSDSITWSKKNSQINKKEEKKPEKQEHEPDRPFDKEPSMPLVSPTAEDLLKQRFLHAQKRSPGNTLMTGGSGSPKDMPSFLRGRSVRELVDATKTNTDKDLGLPSSSTVTQSSASSTPASSSASQVPDDTSLMGMASSSSSKLGSGRKSELTKTRTPMDSLESSFSENTVGPLPTFQTPALAPIQRGDMSLLPDQPFDSHVFVRQLEAGGWKAHGGAFPVTTSDMPASDVTSSNESVPHRHDPAEAIMDLTRSLLKEHGKKLIHQHINRSDLDNQLYLFSSALAELRTEVRVRARNDAAALRSITLLLEREIDGLTQKLQSDIEQLKHDIQVEQNTRKTEVQEESNNLEQEIQDLNNRFTIFLSDLRTEIEQSIKWDTTRRALALVFGIVAIMVCTLAMADYFTRTPAQQVPEADAAHGTSQHGTSPSPPIQHAPRVPVPIDHTLADDHDAQRIPPQSAEELGLLPRYDADEVRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6V5</accession>
    <name>A8Q6V5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730076.1">
        <property type="nucleotide sequence ID" value="XM_001730024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6V5"/>
    <dbReference type="STRING" id="425265.A8Q6V5"/>
    <dbReference type="GeneID" id="5854383"/>
    <dbReference type="KEGG" id="mgl:MGL_3062"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3062"/>
    <dbReference type="InParanoid" id="A8Q6V5"/>
    <dbReference type="OMA" id="ISADQAY"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="541"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="962" mass="102458" checksum="C6BB9E74609FD7CB" modified="2008-01-15" version="1">MPNLLARINRSFGEKHRHAVSASGESPLPSPSPSSPAPLPETSEDALAEGLGMTRSSSITSTPSISSTNRNTLKSLNAKLRSIRLGPGSKDHATVGTAPKGDESSPNHLGAADGQESAAPSRQSFAGIRLSLDRGSRKSSISTIPVDIADMSSAALTDKTSATRDKSMGSSDLPRDSVAHTPVSRDKPFPLVPSGSQSSSPAKPPAGSAPTTQSQETRPPARAPPTPPKPTAHSNDMYSQHDGVPIVPPPADDERKTPMHFASPVTAPASSPVPVPVPLVRCAHASSSSLQAPHSSSPSSSMGPGSFESQSTQQGARQPRQDVFHSISSDDESQQPWATTNTMNLVPPSAESAYPMNSSASEMPTERNREACGIPTSTSAIEYDTRSSQGVFGTFSKRGLDVMGRLRASQNLHRRPSPRHDPSKSEARRRSLFVPILSRSTDSHKTATVQSPTRAWLDWLESPGLVPPRSTKLRGFRSSSMLSSSSSTQSLRTSPTAISPTEETPHALFGTPLRDVVSSPPHSYASSTTPVSPDLTLDDRPPLLSRAEAQQLVIPRLVTRCVESLEKWGVHEEGLYRVPGRSSHASKLRALWNLPGTDLNMAEIGPADLDVHAVCSVLKMYLRELPTSFIPHDTATAMDRICTDMVSAPGSNETALGPLQMKDQTALITQLEPHIQCIPYFEWYLLREMAEHLGVLTQPENVARTKMTLSNLALVLAPSLQISALLMMTLVQMRGALFTYETRPMSSPPPYPASCGSPTPPSSQVTPEKPRPSTLSAESAMASQASLSSSPPPASSATSATNSPRPLKTKPIPTRPLPPVKNASIASHATGANVGSQSNQHPPHYSNAQFADASTEPAAAVDVDAEDVPTLRPLQPPQPPPLSTEVDTEWGEVMNEVHPAELHDDAPQPNPASRISADQAYNPEDTESIDAPPSSPTASTQLPIAQRFSQPRSSILFDTRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q722</accession>
    <name>A8Q722_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3297</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729753.1">
        <property type="nucleotide sequence ID" value="XM_001729701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q722"/>
    <dbReference type="FunCoup" id="A8Q722">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q722"/>
    <dbReference type="GeneID" id="5854059"/>
    <dbReference type="KEGG" id="mgl:MGL_3297"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3297"/>
    <dbReference type="InParanoid" id="A8Q722"/>
    <dbReference type="OMA" id="TWSWCAG"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="435" mass="48067" checksum="46212B41FBF0D851" modified="2008-01-15" version="1">MHAVQTRFWAVRDYFAPVLRESKFKECGLITPDEFVVAGDYLTSKFPAWSWCQGEPSKTRDYLPKNKQFLMIRNVPCLRRVSAVHPRKFAGRPWFPRASSTKSLSRLDNEARDLHGVSDNTEQSIYLEESGDKAHGANDDEDWILTHVDGASGTPSAENSPMTTSPTSKLHVATSGSAFSAQESVPTSTTSSMVLGCVADEESEDSSQLRTPDELDGLGGFAEGVKEREDPAQYVARPTASLSDHLASSRKQMALRTYDCMITYDKYYQTPRMWLLGYDEHGIPLRPSDVYEDVASDHAFKTVTTEPFPHGTPGVGALDTVAMGTASKRKSLAVHVASIHPCKHANMMRRMLQVFHEAENSSKGKSATCGTSSSEHPSSSSTTSSLLTLMMQRARGMRPTNLANNQVSVDMYLVLFLQFMASIMPTMELDTAQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7U3</accession>
    <name>A8Q7U3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729579.1">
        <property type="nucleotide sequence ID" value="XM_001729527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7U3"/>
    <dbReference type="FunCoup" id="A8Q7U3">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7U3"/>
    <dbReference type="GeneID" id="5853885"/>
    <dbReference type="KEGG" id="mgl:MGL_3123"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3123"/>
    <dbReference type="InParanoid" id="A8Q7U3"/>
    <dbReference type="OMA" id="EGFKIKP"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="137"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="370"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="495" mass="54957" checksum="A37A1A9E5C2E6B83" modified="2008-01-15" version="1">MADARLSDKELFELNAKAAPLVILEDVKFPSYNEIVSLTLPDGTRRGGQVLEVSGNKAIVQVFEGTSGIDVKDTHIELTKSSMKLPVSEDMLGRVFNGSGKPVDNGPRVFAEDFLDINGSPINPYARAYPEEMIQTGISTIDTMNSIARGQKIPIFSASGLPHNEIAAQICRQAGLVKKPGKGVHDDHEDNFTIVFAAMGVNMETARFFKQDFEENGSLDRVTLFLNLANDPTIERIITPRLALTTAEYFAYQLEKHVLVVMTDMTSYADALREVSAAREEVPGRRGYPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDMTHPIPDLTGYITEGQIYVDRHLHNRQVYPPINVLPSLSRLMKSAIGAKHTRVDHGDVSNQMYAAYATGRDAASMKAVVGEDALSNEDKLTLEFMERFEKEFVAQGAYETRTIFDSLDIGWSLLRIMPKEMLNRISPKIIKEFYSRKAKHTDETESSAKQSDSNAASADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8G6</accession>
    <name>A8Q8G6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729723.1">
        <property type="nucleotide sequence ID" value="XM_001729671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8G6"/>
    <dbReference type="FunCoup" id="A8Q8G6">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8G6"/>
    <dbReference type="GeneID" id="5854029"/>
    <dbReference type="KEGG" id="mgl:MGL_3267"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3267"/>
    <dbReference type="InParanoid" id="A8Q8G6"/>
    <dbReference type="OMA" id="KEDDKGW"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000436">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="147" mass="16490" checksum="0406231267D87774" modified="2008-01-15" version="1">MSTNSLFDTQFVVKDIDPDGKKFDRVSRVIASSPTLDMTLSLDIATDIYPVHVGQQLAFLLVSSLRRDKAESDATADRDAWRLDQDDNSLAKGFDYVMYGKIFKYDERSTEQVTVYGSFGGLLMALTGSFRHLSKITVGSNVYLLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8Z7</accession>
    <name>A8Q8Z7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator complex subunit 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729342.1">
        <property type="nucleotide sequence ID" value="XM_001729290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8Z7"/>
    <dbReference type="GeneID" id="5853649"/>
    <dbReference type="KEGG" id="mgl:MGL_3377"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3377"/>
    <dbReference type="InParanoid" id="A8Q8Z7"/>
    <dbReference type="OMA" id="ETGDNAW"/>
    <dbReference type="OrthoDB" id="3355484at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24565" checksum="E708E4FCD90DAEEE" modified="2008-01-15" version="1">MANADVQLQHMQVSAIGDIEPLHVGLLLEALTRMVHTPPEAFVERETLLHRSDDEASRTIELSDTQWSNVRRARDQIRLLVRTEHGMTQLVLPQPPSPPGAAPTVAVRTVVMVDVLTPVAESTSISPSIHAPGEHLDPSTIFAMSMEELGHHSQHRSGWDELIQLLQWLPSREVMRYGLRFVLPSDNALVLHELRVFRAIEVRTYLILYIHAYRKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q904</accession>
    <name>A8Q904_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729347.1">
        <property type="nucleotide sequence ID" value="XM_001729295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q904"/>
    <dbReference type="STRING" id="425265.A8Q904"/>
    <dbReference type="GeneID" id="5853654"/>
    <dbReference type="KEGG" id="mgl:MGL_3382"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3382"/>
    <dbReference type="InParanoid" id="A8Q904"/>
    <dbReference type="OMA" id="FYERYRP"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728137" description="J domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34124" checksum="EEA5FE9B63044DB8" modified="2008-01-15" version="1">MLACLCACLPLLQCLLIPFCSPDKNPNTPEVHRRFEQLGLIHRILRDERRDRYNHFLSNGFPKWRGTGYFYSRFRPGLLMVLSLVLSLSVGVQYLIQISSWRRNQKQIENLRRSALAVAWGAAFQTPASASKTLKSRPHPQQKKVQVPIHGFGEMPPAPAQCDIISGKVDWDAEANKVREAMNAPMPATDEAPTIVEVIVFADGSMVVNDAKSGELVPVEPLPESESPTLKSTWPFQLFHSLAGASKETAPEVMDKNDDKDEHRQDIPSESVISPEQETTGFTSAKEPKKSAGKRRKRNNKAQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q914</accession>
    <name>A8Q914_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729354.1">
        <property type="nucleotide sequence ID" value="XM_001729302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q914"/>
    <dbReference type="STRING" id="425265.A8Q914"/>
    <dbReference type="GeneID" id="5853661"/>
    <dbReference type="KEGG" id="mgl:MGL_3389"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3389"/>
    <dbReference type="InParanoid" id="A8Q914"/>
    <dbReference type="OMA" id="RYGSSCM"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="527" mass="55286" checksum="182A99E6CE214325" modified="2008-01-15" version="1">MTLDIFQACERGDTHAVRTILDGEPSLVHATDASNRTLLTQVLQKGNVEIVRELLARNADPRVAQAVATPNEQNAEAFAIVREASLHADTRMANSQSSSRTGSAHSPTSGENANAPPANLPPPEIARLIPCKFFPNCRYGDRCMFQHPIGIALNPADGSFLPPPPGSQPMFYPGPNGMPLQPPPNPYGVPPPYMDMNPPVFQMPFGPNGAVPMYAPPVNALPNNSDSNITNSATDSQQHNASVTEDSQSSTNTTSSNIAQSTAPQTSGSAAPGSAPPSNQARPANKKTAKPSRSDMNQRNRMNGGRPSCAFFARSACRYANECRFPHVLPDGTDARHLPNDQEAKLNKNPTRRTNQASDRRGSDVEAGSNGSSSVQANGKKGSGNARRSSNANNGRGKGSRRGQTTSSHANRKTVQRVPNSDEFPALPGGTTTEPPALQQQSGKANFSAILSAPAPPKPAKTSPSNSETAAKSAAAKSPTSSSSPTAPEEQTEPITESGNNNSQANAQAPSRDFAAVAATQPNAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q935</accession>
    <name>A8Q935_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729367.1">
        <property type="nucleotide sequence ID" value="XM_001729315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q935"/>
    <dbReference type="FunCoup" id="A8Q935">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q935"/>
    <dbReference type="GeneID" id="5853674"/>
    <dbReference type="KEGG" id="mgl:MGL_3402"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3402"/>
    <dbReference type="InParanoid" id="A8Q935"/>
    <dbReference type="OMA" id="ASWNTEN"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="17"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="842" mass="93815" checksum="4E21E0C9D5BA4496" modified="2008-01-15" version="1">MVNFTVEEIRGLMDRPTNIRNMCVIAHVDHGKSTLTDSLVSKAGIIAHAKAGDMRFMDTRDDEKERGITIKSTAISMYFPLSKDELEAVKQPKDGNEFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCIEGVCVQTETVLRQALSERIKPVVCLNKMDRALLELQVDKEDLYQSFQRTIESVNVVIATYNDPVLGESQVYPEKGTVAFGSGLHGWAFTLRQFASRYAKKFGVDKAKMMDKLWGENFFNPKTKKWSSKEVDAEGNKLERAFSMFVLDPIYRIFDSIMNFKKEETFKLLEKLEVVLTSDEQELEGKALLKVVMRKFLPAGDALLEMVVINLPSPVTAQRYRVETLYEGPMDDESAIGIRDCDPNGPLMLYVSKMVPTSDKGRFYAFGRIFSGTVRSGPKIRIQGPNYVPGKKEDLFVKSIQRTVLMMGRYIEPIEDCPAGNILGLVGVDQFLLKSGTLTSSETAHNMRVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVQSWIAESGEHIVAGAGELHLEICLKDLEEDHAGIPLRISEPVVGYRETVQTESSMVALSKSQNKHNRLYVTAQPIDEELCREIETGKVNPRDDFKIRARHLADTYGWDVADARKIWCFGPETTGPNLLVDVTKGVQYLNEIKDSCVAAFQWATKEGVCCEESVRGVRYNIMDVTLHTDAIHRGGGQIIPTTRRVCNAAALLAQPGLQEPMYLVEIQCPDSCMGGIYSTLSRRRGQVFSEEPRVGTPMVTAKAYLPVSESFGFNADLRQATGGQAFPQSVFDHWALMSGVASDKDGKLYDLVKSIRTRKGLKEDVPDLSVYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9D2</accession>
    <name>A8Q9D2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729425.1">
        <property type="nucleotide sequence ID" value="XM_001729373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9D2"/>
    <dbReference type="GeneID" id="5853732"/>
    <dbReference type="KEGG" id="mgl:MGL_3460"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3460"/>
    <dbReference type="InParanoid" id="A8Q9D2"/>
    <dbReference type="OMA" id="NDYMHIL"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="78"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="680" mass="75686" checksum="BA2A0CE56A7B185D" modified="2008-01-15" version="1">MDSIYGFISHVWRVYYPEFEKPTETGELTDKPEARLPDEHEIVEYDAKHNLSEDDVKQVGVAIAEATYAVTGYTWYLLVIFLWIAYFVFALDNQTALNFAYNATSQLESDQGRAMETYSQSYTAQSLFVAISKLFIAKLADIFGRSVAMMVTIFCYTLGFLIMTVSQSGNNYTGGSVFYGIGNSGLQMVIWIILADILSARFRVLGYGFVTLPIFITFVVGAKILKALIASNWRWVPGMFCILAPAVLTPILCMLLYLEHKAKRSGIVPRHPYLRKGFHHALWEFFLDVDLVGLVLLVGGFAMIVVALIRASSPSIVESTWSSAWVIGCLTVGPIILVILLPLYEWFISPRPFLRLSWMNSDVLIAFVVGFFDNMAFMCGFQVAYNWVYISYGYKASDVDLANYFTNSDNLALTFFGVVAGVIILFTRRFKWFLVAGAAIRTIGFGLQIKYRTLDTSMTQAVWAQIVQGIGGAFLGEVTTLLSQITVRHQDVAMVTSVYLTLFSLGSTIGLAIYNALLDSHFPAALDKYATLLSPVHRAFVAASGPYSALTSGPNLDQHPEMKRQVGMAYNESAKHVLYFCIGISAALIVITLFVRDWVLPRSHNVVSNELPEKNPLHMASDTTYDQAIHDAEQSNMDSPTCSSPTEKTTEEHVHEHDMSQQRDIVNMGASTQDVVVTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9J4</accession>
    <name>A8Q9J4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729457.1">
        <property type="nucleotide sequence ID" value="XM_001729405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9J4"/>
    <dbReference type="FunCoup" id="A8Q9J4">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9J4"/>
    <dbReference type="GeneID" id="5853764"/>
    <dbReference type="KEGG" id="mgl:MGL_3492"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3492"/>
    <dbReference type="InParanoid" id="A8Q9J4"/>
    <dbReference type="OMA" id="AKLGCPQ"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="46193" checksum="AF420BDF6EBE307E" modified="2008-01-15" version="1">MTQAPDHATAKAKESAMKRGNAKTATMVDTMYFTPAQWERLQVRTLGNSMSAAKWEQIQMAACSFITAVGAKLGCPQSTIGTAQLLYQRFHLFYRPADFVMHEVALACLFTSTKLNDTQKRLHEVLLASYAFRYPDLLGRPPATKDGTNGRQADWIAHTHVSENDMDADVLHREQVCLLTLERMLLQCMCYNFQLRSSRLLKWTTKLARLWDMPKQHAALSWRIACDSHRTNAPWLYTPLTVAIGSVYVCVALMHAAGHSIPTAQQFEHESSRWELRWSTCMEDVDDVAIRLLQLYAQHALSLMSERKSERLVPPHVAYPPPMGLLRWRTFAPQDLSSCVTQALIYVRQRAQTRAQWPTDDRSDLLGQRKRFAAEARHDDTLASTIFTPTPDDATRIVATRYLLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9M9</accession>
    <name>A8Q9M9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3512</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729477.1">
        <property type="nucleotide sequence ID" value="XM_001729425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9M9"/>
    <dbReference type="FunCoup" id="A8Q9M9">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9M9"/>
    <dbReference type="GeneID" id="5853784"/>
    <dbReference type="KEGG" id="mgl:MGL_3512"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3512"/>
    <dbReference type="InParanoid" id="A8Q9M9"/>
    <dbReference type="OMA" id="ANDCAIH"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="136" mass="15324" checksum="5BEAD847651D2FA7" modified="2008-01-15" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPTAGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVLALQESAEAYLVSLFEDTNLAAIHAKRVTIQPKDIALARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA17</accession>
    <name>A8QA17_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729115.1">
        <property type="nucleotide sequence ID" value="XM_001729063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA17"/>
    <dbReference type="FunCoup" id="A8QA17">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA17"/>
    <dbReference type="GeneID" id="5853421"/>
    <dbReference type="KEGG" id="mgl:MGL_3582"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3582"/>
    <dbReference type="InParanoid" id="A8QA17"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="357" mass="39839" checksum="BAA8EC7751E42E4A" modified="2008-01-15" version="1">MHDSRPEKHELTDENENAENAMNSSKKARITHDITLTNDKLRARTTIIVPGMNVFLRLPSGMMKLVTLEKGKTVSIGKFGNFDANSIIGKPFGPTYEIRPDGTLEIMHQAVAEALDAFHVATYNFERCPEKIRNMRADSLSQCLSFSNVQAGGKYLVVDGIGGLLAGAVLERMGGSGSVYLVHDTDSPPALELMSQFNLTSAHTSGVLKTLHWATTESRWTLPSHMSEELSREYTSERERNRAKKKRTAIEDFLATRQQFFEGEFDAAIIACPYETYSVIHRITPYLSGSANVVVHSPHLQPLVETQARLRANHSFVNVSITEPWLRRYQVLPARTHPDMTTSASGGYILHAIRILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA19</accession>
    <name>A8QA19_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX14-like KPWE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729116.1">
        <property type="nucleotide sequence ID" value="XM_001729064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA19"/>
    <dbReference type="STRING" id="425265.A8QA19"/>
    <dbReference type="GeneID" id="5853422"/>
    <dbReference type="KEGG" id="mgl:MGL_3583"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3583"/>
    <dbReference type="InParanoid" id="A8QA19"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="39"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="87" mass="9620" checksum="FDCE74F6ED806850" modified="2008-01-15" version="1">MTLSALRARRCSSTCSGNQGQTPNGHVKDVKPSEGQQEQYPTSFHKIVELIATGQESNIPGIRDIPLQINSQLPSKSKMECPKKPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAG7</accession>
    <name>A8QAG7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729259.1">
        <property type="nucleotide sequence ID" value="XM_001729207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAG7"/>
    <dbReference type="FunCoup" id="A8QAG7">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAG7"/>
    <dbReference type="GeneID" id="5853565"/>
    <dbReference type="KEGG" id="mgl:MGL_3726"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3726"/>
    <dbReference type="InParanoid" id="A8QAG7"/>
    <dbReference type="OMA" id="CQTCTHS"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="45"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="509"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="539"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="626" mass="68667" checksum="C0F41737952475A1" modified="2008-01-15" version="1">MSELAAASPSAGPSPSVVDAPLTTRLPYNVPQDNDIQIPAYARISTRAEHDLRRLYEAVRQARRITVVCGAGVSVSSPANIPDFRSASGLFATLKKRYPESGLSSGKDLFDARLFQSESSTAFFNSMIAELKDLSDAAQPTLFHHMLKRLDREGRLQRVYTQNIDGLEEKAGLTLGFGSPGASIPTSKRKREPVMRTQSRQHLFARSQSDSSVMHGSSTQDRGACQPLFPRAIPLHGSLASMTCVLCSHKLRLERNQTQAEQALHSLHHGEPVWCEQCEITDQLRTEAGLRSRGIGRMKVDVVLYNGENETAEHVGACVERDLLGLRDPCEPDVPETPAETRARERRERQARESANPADAGLGLSVLSGEIKAEDALASAFNEEATDPAVVEQSRRPRRLKPLPPDLLIVAGTSLKVPGTKRIVREFAKACHSRDSERKKEPPVRTVYLNYDFPSAASEWTGVFDMWVQGDVQQASVGLCTPLESKAAAGADPLVESLVAQHSWHAYPQTPSLQGSKKRLDSFQEPVSVSTPASSYKRQLQSLPQSQSLSQLQSQSQSQSQAQAQAQQQSRKVLKKTPVAQLGMVSGKLSSFSASRTGKAIDIHENRSIRAQPQPHIQSKDKQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAH2</accession>
    <name>A8QAH2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3731</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729264.1">
        <property type="nucleotide sequence ID" value="XM_001729212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAH2"/>
    <dbReference type="FunCoup" id="A8QAH2">
        <property type="interactions" value="832"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAH2"/>
    <dbReference type="GeneID" id="5853570"/>
    <dbReference type="KEGG" id="mgl:MGL_3731"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3731"/>
    <dbReference type="InParanoid" id="A8QAH2"/>
    <dbReference type="OMA" id="SNAFMTN"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="989"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1066" mass="119843" checksum="926C32EAEE29751D" modified="2008-01-15" version="1">MSEMNEAWNHWEQETISHVFGITLDEREAASSSLVHVPELQEELLAEKQSDSQSAVVATLDMADRILIARLSLPDAPQTSWDYILQAWIRCRHEEQRLQSHAPPLVFLPEALHALQHVRGLLISYAGLLLDMPDMFPRCEKHGDMLGPHALSPTLLNLAAVHDDTPLPTVCEWMAVPPSLAPVFLDELIVRFSQDDSLDSVLGRAMRALTQYILKPPGTSSAAASTSARSPQASSSWPLTATASAASAATSTSTQNADLNDVQSVLAQMLGLPDPRAHGSSQFAPAMPAPEGMSIAQLDWQPIQMAVVAAVEHKTLAAAMPFFSSFAPTTSAPNMERESILGPLLRLSCFADAFPSIARDSFSHARSRSPVELENSMSSLRMSLRVVQASNFRIFNALVRAGPEPRERVLAYWGDICQLNAKRGAMQVRAREVATDAFMVNVLDVLLRFAEPFAEPTCSKIDRIDATYLRRQKRWDTSSLTRILASETEGMQWMADTPETERKNVPNFVTDVFFITTRLMNVALGKALRRIEHREKEMDRLQKRIDELESEQSMWQGMPHASTVEQILQRARTQSDKLYSEVLAAQTLLMEPEFVQRTLTFVSFTMAWLVRLADPRSLHPHTTVQLPLPQEVPNVFRMLPEHVFEDACDTVLFYSRRKPDVLDAPARESITTFCTVFLSSGWFIRNPFLKAKLAEMLSYNVMPYGALSMGVLGDTINNQPLAIAHLVPAVMSFWIQAESTGSNTQFYDKFNIRYHLAQVFKAIWDNVDHKRQLHAQAQDHQSEFVVFINRLMNDVTFLLDDALDKLTELHAKQGEMDDVESWQRRPIHERQEFEGIVRTIKAQIRSDLGLGHEFLRLLIMFTKETSASFMMPEIVDRLAAMLDYNLDVLVGPRCQGLKVKDPKAVGFDPRSLLSEILSVILNLAPHEAFAVAVAHDGRSYSRETFSKAASISQRHMLKSPVDIDALAQLVDRVEKIKEREAMEEEDLGEVPDDFLDPLLATIMRDPVRLPTSRAVVDRSTIKAHLLSDGTDPFNRMPLTLDDVTPADDVREQIESWIQERRRQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAM2</accession>
    <name>A8QAM2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728993.1">
        <property type="nucleotide sequence ID" value="XM_001728941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAM2"/>
    <dbReference type="STRING" id="425265.A8QAM2"/>
    <dbReference type="GeneID" id="5853300"/>
    <dbReference type="KEGG" id="mgl:MGL_3781"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3781"/>
    <dbReference type="InParanoid" id="A8QAM2"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20438" checksum="67ACB72BC0FF3023" modified="2008-01-15" version="1">MTWEVQSRRARQTQSKLDAKLTTYSQYVSELARGIQPVVPSSVSAAPTFSTPDHAVAVDINGGSSAPKDHTAMETDIQSLLVQYSEEIDELSSSLNDPLLPPNTTQLHLVQRHRELLVEFEREFFRSKTHVRQTLDRQQLLGHVKQDIRYVSKVRCCFIVRLHTHVATTGPSMRQKSSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAU1</accession>
    <name>A8QAU1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729042.1">
        <property type="nucleotide sequence ID" value="XM_001728990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAU1"/>
    <dbReference type="FunCoup" id="A8QAU1">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAU1"/>
    <dbReference type="GeneID" id="5853349"/>
    <dbReference type="KEGG" id="mgl:MGL_3830"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3830"/>
    <dbReference type="InParanoid" id="A8QAU1"/>
    <dbReference type="OMA" id="CIFAKND"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="172" mass="20205" checksum="DD4EF6DA1E123CD4" modified="2008-01-15" version="1">MGRISEYLVIGRHLPTEREPVPTLYRMRIFAKNETIAKSRFWYFVRQLRKMKKATGEIVTVNKIEEKTPTKVKNFAIWLRYNSRSGTHNMYKEFRALSRAEAVELMYQDMAARHRARFGSIHILKVAEVQKVSDLRRPYVKQLTAKGLRFPLPHRRTSGAGIYAAKRPATFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAV8</accession>
    <name>A8QAV8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729051.1">
        <property type="nucleotide sequence ID" value="XM_001728999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAV8"/>
    <dbReference type="STRING" id="425265.A8QAV8"/>
    <dbReference type="GeneID" id="5853358"/>
    <dbReference type="KEGG" id="mgl:MGL_3839"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3839"/>
    <dbReference type="InParanoid" id="A8QAV8"/>
    <dbReference type="OMA" id="TRPPWER"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="512" mass="56810" checksum="300223203A5CF843" modified="2008-01-15" version="1">MVRLRRTTRSTSVTAATEEDAPRRSTRPRRPRAKTPVSDASGDDSDPTSHAVEERQPLLRTRRSARVSSTRNVPTAQDATDELQDPLDDAQGAAAEAENEDERSVAEGADADEHSGMEEDDMVEIEGQVYRIENDGLVLDTDPAGEKKVDKNGRLLGGRTYRIATLSSPQRDTPDRLYMLSIDVARGLGYRDSAYFFRKNPLFHKIFLTPEEKEQLVNDGRLNSTLRTRNVTMVAARSVFQLMGARVVERGRLVTDDYYEAQARASGKREGAPVSQPSMQDILRAERRRESDRERERGRRRPDASTHTTVDPQGEVVTTTFGDAGHAPFDRHGHTAQRRQFLLRAQITEENWLAEYARSVRAANAELLASRRSRLVAFPRHQHEARSASLLATSAVAAAETAIATTSSSSSSTTATEVRHAIDSEHLVCDTRPPWERELTPMVDARARAHARREREPPLGLYDPHTHSALLPTEAQPQAASFAKVDDIPRGVPPAARLAGVYTTETCLMAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB12</accession>
    <name>A8QB12_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729079.1">
        <property type="nucleotide sequence ID" value="XM_001729027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB12"/>
    <dbReference type="GeneID" id="5853386"/>
    <dbReference type="KEGG" id="mgl:MGL_3867"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3867"/>
    <dbReference type="InParanoid" id="A8QB12"/>
    <dbReference type="OMA" id="FLAYIPP"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="108" mass="11100" checksum="52D25148C1ACF316" modified="2008-01-15" version="1">MLSKEVDPRWTAMPSMPGMSPMPGMPGMPGIPPMPGMPPMPGMPPMPGVPPMPGMPPMPGMPPVPGMPPMPGMPPMPPLPGMSPITHVDSPSTSQQDSGAQDTLPQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB40</accession>
    <name>A8QB40_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3881</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729093.1">
        <property type="nucleotide sequence ID" value="XM_001729041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB40"/>
    <dbReference type="STRING" id="425265.A8QB40"/>
    <dbReference type="GeneID" id="5853400"/>
    <dbReference type="KEGG" id="mgl:MGL_3881"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3881"/>
    <dbReference type="InParanoid" id="A8QB40"/>
    <dbReference type="OMA" id="IDWMYRT"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725229" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="610" mass="66267" checksum="A4F53FDF5C050AE3" modified="2008-01-15" version="1">MFGHFLFAIVAISAAHVVHAARTFSHVHEVSDTDWDYIVVGGGLGGLVVSKRLAEDEGKNVLIIEAGHDDRDDPKVFNVDKYGQYIGTDLDWNFVTKKQPIAGGKSKTIRGGKTLGGSTSINGAAWNRAHKIQYDHLGNITGDDRYNFKNLQKYMNMAESFVPPTDEQRAAGADYLPEAHGSRGPLSIGFSAIRNKNKKRMFTGPGQGSFLKSIQKSLGVAHLQDENSGNNTGAAYTPTSISQDNRRQSACNYFEQSGNNVGVLLGWTVIQLSWKNQDEGRVSGVVIKKNEDGKPHTVETSGEVILSAGALNTPGILERSGIGAKDVLQKHSIEQIIDLPGVGKNLQEQTMNTMGGKADLDWSGGGPSNMIANTAVTQLMSNASNVFKYIHRNMDKWAHSLVSQGHVVNADAIQKHWTLSVDATFKKGAPVCEHFFDTGYPADSYGIDTWCLLPFSRGSVHITSKNGFDKPEVDPNYFAIPIDMDMQVAALRANRRVFQTSPLHDLLKKDETVPGFDHIPDDPNHGSYAKWQAWILGTDGTGGFGSVSHPIATCSMIPKKDGGVVDPEFKVYGTNNLRIVDGSVLPIQLSAHLSSSLYGLAELAADVIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBA1</accession>
    <name>A8QBA1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728900.1">
        <property type="nucleotide sequence ID" value="XM_001728848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBA1"/>
    <dbReference type="FunCoup" id="A8QBA1">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBA1"/>
    <dbReference type="GeneID" id="5853205"/>
    <dbReference type="KEGG" id="mgl:MGL_3894"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3894"/>
    <dbReference type="InParanoid" id="A8QBA1"/>
    <dbReference type="OMA" id="HHIAMMA"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="168"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="683"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="842"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="797"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1021" mass="107629" checksum="A1EA177FD66EE89D" modified="2008-01-15" version="1">MPYHYAPTPGYMPHMMEIPPQHGPHAHPNSMYDASVQPVPHDVHGMPSSTMPQPLPPPQPPTPYTAVPPSAQPPSGSVAAAAAAAAASGAPPPVMHAPVHMHSVPSQSSIHTHPHAHAHTHPHAYAQPQPPPPPPPQPALLPQGQPGAVAFAARPAPVVPTSGPTPTVYLATYSSVPVYEITVRGIALMRRRSDGYLNATQILKIAGIEKARRTRILEKEILTGEHDKVQGGYGTFQGTWIPLQRAQELAISYNVYHLIRPLLDFDPTASRAVTAQQQGAKRKAESSGAAAHTTGAVAVGAGAGAGVGPGLVAGMPGSAPSVVPGSSGGSSSSSITPMRAPHQQPRFLTLRPPRSSTLGATAGGLVHTLPRDDDLPAMHASEGVPPGSHPTQRTALESYATHGYTPQGVPLPPAENAASAAGAGSEPLRSSDANAHVHDLNVLSATPLHSAAPPSTSVDEPAEVKGPRFADKAVPPHLGDERERRAREVLTGLFVHESVHAGAASASATSKSPAASTGATAASSSDAPLDQLHALLHELGVDPSRRQHRSPLNLVIDDHGHTALHWAAALCRLSLVRMLTALPPSCGGANVFVGNYAGETALHRSVLVTNAYELSQLPELLDILAASLETRDHRKRTVLHHIALVAGLKGRAAPARYYLSCVLDRISKDASTKASLLDAQDDEGETALSIAARLGNTNMIKMLLDAGARKDLPNYLGITPLDWGISNASPDGGVLQELGSYRPADVVRSLMKPSPGPVKKSQDVREKLVQTLDELQVIFDREVNVKQNAIETTQTHLQAATRELAARRRDIQAAQAAVTEREEVRQRCENLQRALALFPAADHQSAGRDNDQKNQDSQGDGHTLDLQDRVPPSAWFDAPLAEADAALAQDASESAQVAAIVRLRWLLMHCDEAMKSLRANIQERQDQVAAQQAQYHRVVALCAQVPPDKVDGLLDELLAAVESIGSDVDTSSVASFMDKVGRAQSMNKDGAAASGIAVDTPQTPPPLLPPQTIIPPAPQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBV2</accession>
    <name>A8QBV2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3944</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728950.1">
        <property type="nucleotide sequence ID" value="XM_001728898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBV2"/>
    <dbReference type="STRING" id="425265.A8QBV2"/>
    <dbReference type="GeneID" id="5853256"/>
    <dbReference type="KEGG" id="mgl:MGL_3944"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3944"/>
    <dbReference type="InParanoid" id="A8QBV2"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="558"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="452"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="883" mass="96079" checksum="F3BB6D97C482452E" modified="2008-01-15" version="1">MPGIPTSSGTRETQSRNPFLTTLPRGNEGDMRSAGRTGESSSRITSSGGSPGTTAQSEFHPAAMESQSTFHDANELDTLSASHGSNRPSTDNSDFGDASSFISIPIYDTPLDFDFIHESMPPVSTSGGAPLPLHREVSGLYPHRNGVNTPTAHLASSSSQRTVKQSTIRDSKPSDAALLTDALANNDVGQPAPARRTTVGDARASRPIATDPYKQPQFKRDTAFSSMDSARPSSRPQTPGSASRPASGMGASRSSATLLSNRSSYRNGQNVSALRADGFRSPTRAEMSEQTRAASATPGTPAPAMATSESDMLDAPTTSTIKPIKRSKQKKSAATGVAAGAAATAGAGAGAAGLSSVNKPDAPTAGAQASQLASDPPKSIKPAKQAPQHANAVPFGEKPVKHVNPLYVDIATNPKKPWYKRFPWLPWLLGALALAVILGVALGVGLGVGLSNNDDNKNLSQKPNSKDDGQSSDSSGHGGKPASVPKDLKPLPKWNWTSTTNKVFGTNLGGLFLLERWMFEDWMVEVGGLDAWDEYSLSEKLGDKLQEPLRQHIDSWFTEDDMNTLQDAGVNMIRIPLGYWPFLSTKLTNEPYQNASHLEKLSDIMYWSWNRSMYVLIDMHGLPGSQNNDQSSGHNYTSNDNQQISEWYSDANQNYSRQMVDNMLGWLDAHPAKSVVAGITTVNEPKVYSKRSYESALRDFYDFSIERLKPHGIPLVAHHAFVDSPYQHWKSYASNKSPDTFIFDDHPYPAWFQTPEPSDKDKMISSICQYKEDMIDFPVPVLYGEFSAINILNDTQWTTDYLKTQLKVFGWSAGSTFFNFRVNKSENPVLASPYAIGGKYSMLEMLQADSEIGHFPPRNTTMPVIEFTNQLSNSCGDDPQITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCQ7</accession>
    <name>A8QCQ7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_4036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728869.1">
        <property type="nucleotide sequence ID" value="XM_001728817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCQ7"/>
    <dbReference type="FunCoup" id="A8QCQ7">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCQ7"/>
    <dbReference type="GeneID" id="5853175"/>
    <dbReference type="KEGG" id="mgl:MGL_4036"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4036"/>
    <dbReference type="InParanoid" id="A8QCQ7"/>
    <dbReference type="OMA" id="GPCHVLK"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="17"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="335" mass="35886" checksum="5E76C3482B9A16C0" modified="2008-01-15" version="1">MAPIHDKSDTGLKKPHKVVIIGSGPAGHTAAIYLARANLEPVMYEGFLANGIAAGGQLTTTTDVENFPGFPDGIGGSEIMDKFRAQSQRFGTVIHTETISKVDLSSRPFKLWREGFENEEPELAEVLIIATGASARRMHIPGEEVYWQSGISACAVCDGAVPIFRNKPLAVVGGGDSAAEEATYLTKYASHVYVLVRRDELRASKIMAKRLLSHPKVTVLFNTVALEAKGDGELLNAIRVKDTKTNEERDMQVNGLFYAIGHIPATSIVKGQVDLDEDGYILTKPGTSLSSVHGVFAAGDVQDKKYRQAVTSAGSGCVAALDAERLLAEEEAGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCV1</accession>
    <name>A8QCV1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728883.1">
        <property type="nucleotide sequence ID" value="XM_001728831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCV1"/>
    <dbReference type="STRING" id="425265.A8QCV1"/>
    <dbReference type="GeneID" id="5853189"/>
    <dbReference type="KEGG" id="mgl:MGL_4050"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4050"/>
    <dbReference type="InParanoid" id="A8QCV1"/>
    <dbReference type="OMA" id="ANVNVWM"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF100">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="344" mass="39502" checksum="93A75A52D1BE81A1" modified="2008-01-15" version="1">MWTNYIKNRKPVVLDGFPDDPEWRGERWTDLAYLRDVSGDASVKVEPIHPEFKCFGTSMPRKTMKFGQFLDLVQDAKQAGRYYLTTQYEENRDDSESDDNEWPSLDPILPSPTHTLKSDLPMRPRILGDLVLQQCNFWVGSGMEPKSSGLHHDFHDNLYILLSGHKRFVLFPPDAYPYLHLRGHVEQIHKNGLLVYEEAGRIRPDGLDVLDAAHWRFASRSHQMGQRKKRRSTNDEAHNSYAEAKMALQELKANYEEDDDDDNDESLDDDQEDDDEGGVLDSVSEAGSELNVCDDDEQLLADLEFKEQEPPSFSRIPTSVLHKHFGIEPPIAPSSAEKEHIYFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCW4</accession>
    <name>LIP2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Secreted triacylglycerol lipase LIP2</fullName>
            <ecNumber evidence="5 6">3.1.1.-</ecNumber>
            <ecNumber evidence="5 6">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LIP2</name>
        <name type="ORF">MGL_4054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2011" name="Microbiology" volume="157" first="3492" last="3499">
            <title>Purification and characterization of a secretory lipolytic enzyme, MgLIP2, from Malassezia globosa.</title>
            <authorList>
                <person name="Juntachai W."/>
                <person name="Oura T."/>
                <person name="Kajiwara S."/>
            </authorList>
            <dbReference type="PubMed" id="22016565"/>
            <dbReference type="DOI" id="10.1099/mic.0.054528-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2016" name="Microbiology" volume="162" first="1069" last="1079">
            <title>Secreted lipases from Malassezia globosa: recombinant expression and determination of their substrate specificities.</title>
            <authorList>
                <person name="Sommer B."/>
                <person name="Overy D.P."/>
                <person name="Haltli B."/>
                <person name="Kerr R.G."/>
            </authorList>
            <dbReference type="PubMed" id="27130210"/>
            <dbReference type="DOI" id="10.1099/mic.0.000299"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6">Major secreted lipase involved in Dandruff and seborrheic dermatitis (D/SD) probably via lipase-mediated breakdown of sebaceous lipids and release of irritating free fatty acids (PubMed:18000048, PubMed:22016565). Has triacylglycerol lipase activity and is able to hydrolyze triolein, tristearin, trilinolein, tripalmitoylglycerol and trihexadecenoin (PubMed:27130210). Hydrolyze diacylglycerols such as distearin, dilinolein, dipalmitoylglycerol and dipalmitolein (PubMed:27130210). Shows high esterase activity against 4-nitrophenyl palmitate and 1-naphthyl palmitate but not 1-naphthyl acetate, suggesting that it specifically recognizes fatty acids (PubMed:22016565). Mostly converts monoolein to di- and triolein, while free fatty acids are only produced in low amounts (PubMed:27130210).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">The activity is significantly increased in the presence of Triton X-100 and partially inhibited by PMSF but unaffected by univalent and divalent metal ions (PubMed:22016565). Activity is significantly decreased in acetate buffer compared to that in citrate buffer at the same pH (PubMed:22016565).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="5">Optimum pH is 5.0.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="5">Optimum temperature is 30 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5 6"/>
    <dbReference type="EC" id="3.1.1.3" evidence="5 6"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728887.1">
        <property type="nucleotide sequence ID" value="XM_001728835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCW4"/>
    <dbReference type="SMR" id="A8QCW4"/>
    <dbReference type="ESTHER" id="malgo-a8qcw4">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GeneID" id="5853193"/>
    <dbReference type="KEGG" id="mgl:MGL_4054"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4054"/>
    <dbReference type="InParanoid" id="A8QCW4"/>
    <dbReference type="OMA" id="RDHASEH"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="BRENDA" id="3.1.1.79">
        <property type="organism ID" value="13511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000459490" description="Secreted triacylglycerol lipase LIP2">
        <location>
            <begin position="20"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="115"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="360"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="W3VKA4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18000048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="22016565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="22016565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="453" mass="49488" checksum="A9A2A6D6BE437EC4" modified="2008-01-15" version="1" precursor="true">MKLSLVVLTLISVAAQALALVARENLPKPQNDPFYQPPDGWESKKVGTILRSRKVNINTLVKDNLKEAWQLLYRTTYRSDDEPTTTVTTIMVPHNAQNDSLVMFGDFEDAGAPQCAPSYTWRAGLTSDVSSIFNVGIAMLYLQEGYIVTMPDKEGNKGAFGSGHVEGRQSLDGIRATLAFDKIGLNKNARVVGHGYSGGGIQCGWTAALKKSYAPEINSVGWYTGGTPSNLTALVERINGGPFAGYVAGGLGGVISTYPDVKAYTDKVFTKQAQKDLEFPQKHCQFEVVLRFPFKNFYDKSFSTVGKRFLYEPVVQKALNELTMGTNPEFTPDTPVLMAHGISDEIAPYEAAHKTYESWCKNGADVEFLSFVNPVSAHGVTTVTSSVPGFLWNRDRLQGKPVQNGCREIKNHDAGINSNALGEDFESALGLLKGLLGDKIGPNDEYLKDALHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCY8</accession>
    <name>A8QCY8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septicolysin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_4058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728723.1">
        <property type="nucleotide sequence ID" value="XM_001728671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCY8"/>
    <dbReference type="GeneID" id="5853069"/>
    <dbReference type="KEGG" id="mgl:MGL_4058"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4058"/>
    <dbReference type="InParanoid" id="A8QCY8"/>
    <dbReference type="OrthoDB" id="4009151at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12208">
        <property type="entry name" value="DIP1984-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047741">
        <property type="entry name" value="DIP1984-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038048">
        <property type="entry name" value="DIP1984_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20935">
        <property type="entry name" value="DUF6847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="18040" checksum="2D0329A5435EF6A7" modified="2008-01-15" version="1">MLLAEALAERAEAQRRYEQLMQRLLRVVRVQEGDEPVEDPEELLTTANAIIDRMDWLIRSVNKTNTVTMFDEKHTLTDAIAFRDMALKRRKLYSDVATRASTSQDRYTRSEIKYVSVVDVREMQKKVDKLAGEYRKLDTQIQKMNWEVELIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD37</accession>
    <name>A8QD37_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728770.1">
        <property type="nucleotide sequence ID" value="XM_001728718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD37"/>
    <dbReference type="GeneID" id="5853099"/>
    <dbReference type="KEGG" id="mgl:MGL_4105"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4105"/>
    <dbReference type="InParanoid" id="A8QD37"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="88" mass="9200" checksum="6950F718C3AF878B" modified="2008-01-15" version="1">MPTQNYGQPYQPQAYPMTNQYGGQGAYAPPNGPPPNGPSQAMPYQPPPGPPPSDGDDVPSYAPPSYPPPGHNSETTYQPPAGPPPNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD46</accession>
    <name>A8QD46_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728779.1">
        <property type="nucleotide sequence ID" value="XM_001728727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD46"/>
    <dbReference type="STRING" id="425265.A8QD46"/>
    <dbReference type="GeneID" id="5853071"/>
    <dbReference type="KEGG" id="mgl:MGL_4114"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4114"/>
    <dbReference type="InParanoid" id="A8QD46"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="126"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="248" mass="28245" checksum="D23B0F4256E00806" modified="2008-01-15" version="1">MNLRGKLNTKYHGTKYTELNINARMLPTKASIGMNGTHSNMVFKTLYAGWKTRQVSRFPLPESRLNTHEASAGTVEAQHITETVHEKNTDPASPATRTIDRVPPGTVPEWFSAGSYAFARDGSKKMPIDLDERDIRERFIRGSGPGGQAINKLSTNVELVHIPTSTRITCQLTRSRAQNRELARRQLSQRLEWLIKQNWSHVSAQQGTKPVSRELSPSVIQSNWDKARKRKQNKRKKQRRRASNESFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDA3</accession>
    <name>A8QDA3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_4170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728691.1">
        <property type="nucleotide sequence ID" value="XM_001728639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDA3"/>
    <dbReference type="FunCoup" id="A8QDA3">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDA3"/>
    <dbReference type="GeneID" id="5852994"/>
    <dbReference type="KEGG" id="mgl:MGL_4170"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4170"/>
    <dbReference type="InParanoid" id="A8QDA3"/>
    <dbReference type="OMA" id="NIRWHYE"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF30">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="121"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="316" mass="33945" checksum="D70A7CA059CDC174" modified="2008-01-15" version="1">MPGKHAVVVGAGVLGLTSARYLREKGYTVTILARELPHDTTSQSFASPWAGANWCSFARGNENEKRRDAYTYKQFQELAKELPEDMLAFMPFTCYDVKPNDSETYWFHKECGGSAAALVPDASLVVNATGLGSQDMPEASESLAYPIRGQTVLVHAPRFRDMDTAHCISKIGSGGASYVIPRARSGFVILGGTFHARVSNPLTPDPAVTERILKDAVLLAPELLPENVDAHDPNAWKSVEVVGVNIGVRPAREGGARVELDSKPVYVGHRPVGVIHAYGIGPAGYQASHGIAAEVCDLAEKWESICSSDAGARAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDD9</accession>
    <name>A8QDD9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728712.1">
        <property type="nucleotide sequence ID" value="XM_001728660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDD9"/>
    <dbReference type="GeneID" id="5853015"/>
    <dbReference type="KEGG" id="mgl:MGL_4191"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4191"/>
    <dbReference type="InParanoid" id="A8QDD9"/>
    <dbReference type="OMA" id="ECKAPND"/>
    <dbReference type="OrthoDB" id="3349465at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725267" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22626" checksum="1B09E79080DF855F" modified="2008-01-15" version="1">MKVSAIVFAAAFFALSQAAPSSKNGLKCKPSGKTGKIIGHNGGAKHRDMYEFNFKAGSSGPKVLRASDDATQEFEFYTCEAPSDKFAGAALGASYGQLRSKDDKNMCVTSGTSVTKNEDGLVSITSHNDGRVTLEKCSSDEETARRQWFSVSQGVPTCPPLLSQMGFKNDVTQSYIGQNNDHTAHFEANLFYNMDEHIYLADKVPNGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDI3</accession>
    <name>A8QDI3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_4209</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heteropentamer composed of five different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000022">
        <property type="protein sequence ID" value="EDP41434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728648.1">
        <property type="nucleotide sequence ID" value="XM_001728596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDI3"/>
    <dbReference type="STRING" id="425265.A8QDI3"/>
    <dbReference type="GeneID" id="5852963"/>
    <dbReference type="KEGG" id="mgl:MGL_4209"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4209"/>
    <dbReference type="InParanoid" id="A8QDI3"/>
    <dbReference type="OMA" id="SINKRFA"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="UniPathway" id="UPA00661"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000018">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF352">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="18">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="136"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="19">
        <location>
            <begin position="276"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="16">
        <location>
            <begin position="492"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP41434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="702" mass="78654" checksum="FC272DA6862E1408" modified="2008-01-15" version="1">MKTLAEERANPPFDVEAMAVANHGSKERLDYKRKVMSEIERLPAFFNDDFYDLTKDQLRERTFIKIGHIVDWLQNEDMDTFRQRLEVLSVADPGFWTRFGVHLGLFTNCLRSGCTSSQFAYWVRKGMLNCHKFYGCFAMTELTHGSNVQGIQTTATFDPNTDEFIINTPDLNATKWWIGGAAHSATHSAVYARLIISGKDYGVKTFVVQLRDPLSFSNMPGVTIGDIGKKMGRDGIDNGYIQFSNVRVPRAHMLMRHCQVTRDGQVSEPPLQQLAYGALLTGRVMMAIDSSNIGKKAITIAGRYAAVRRQFKSDAKSEVETKLIDYPIHQRRLMPLLAQSIAFQYTGYQLAHMLEETTRALDALEPGDPKLEGVIELLKSTHASSAGLKAFCTWATLSAIEVCRQSLGGHGYSSYTGLAPLYADFAVHCTWEGDNTILALQLGRALVSAYGESQNGKKQGQALAYLNDIDASLNGRCQSQEELNTLAGVEAGWLTASAHFVKVAYDEFQRCIKAGDSRERAAEKCSQLRFVAASVHTSGFIFRQFRAAVESMPDRGDGVKKALTTVALLYGLWQMEEKSGFLLRSGWLKPEQFDFVARRVSELCAEVRAFAIPMIDSFSYTDFVINSPFGRFDGDVYRAYFDMIRRNNPPLKPHPYRDSLVLPLLNRVIPEQDDVAEAMNLDEDIEEIQNDIKEALASQQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QE05</accession>
    <name>A8QE05_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Chitin synthase</fullName>
            <ecNumber evidence="2 12">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_4248</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 12"/>
    <dbReference type="EMBL" id="AAYY01000025">
        <property type="protein sequence ID" value="EDP41393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728607.1">
        <property type="nucleotide sequence ID" value="XM_001728555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QE05"/>
    <dbReference type="STRING" id="425265.A8QE05"/>
    <dbReference type="GeneID" id="5852915"/>
    <dbReference type="KEGG" id="mgl:MGL_4248"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4248"/>
    <dbReference type="InParanoid" id="A8QE05"/>
    <dbReference type="OMA" id="HIYESTI"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="138"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP41393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="439" mass="49970" checksum="1189372DEFA26E15" modified="2008-01-15" version="1" fragment="single">MVLPSSGRKSGTTPHAQVEQHVLQAISAGNAAIEEGPLWHDRLNDLEESAEGQALFEAYNYDEPEYEQIQDSITERLKMRSSSGSLIDSNKPSFEENESSLYLGLPPSHHSAPILPEQLDQESLQWAKRQRPPQHGKKRQIHLKSGNWILDYAVPSPIANAVLLEYREQGQPKEFTHLRYSAVTCDPDEFSAENGWGLRISNEYHRSTEILIALTYYNEDRSLLTRTLHSIMQNIRDMVRKKWSRYWQKCEEEGQPGWQRIVVSLIFDGIEPCDKETLDILATIGVYQDGIMKREVNGNETIGHIFEYTTQLSVDPTPVLVQPSPGSDNNLVPVQMIFCFKQKNSKKINSHRWVFNALGRLLQPEIVVLVDVGTKLGHLSLYHLWKAFHNNPQLGGACGEIHAMIKHGIKLFNPLVASQNFEYKISNILDKPLESMFGY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR17</accession>
    <name>KAD2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylate kinase</fullName>
            <ecNumber evidence="1">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ADK1</name>
        <name type="ORF">MGL_0573</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="1">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and disassembling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732798.1">
        <property type="nucleotide sequence ID" value="XM_001732746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR17"/>
    <dbReference type="SMR" id="A8PR17"/>
    <dbReference type="FunCoup" id="A8PR17">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR17"/>
    <dbReference type="GeneID" id="5857104"/>
    <dbReference type="KEGG" id="mgl:MGL_0573"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0573"/>
    <dbReference type="InParanoid" id="A8PR17"/>
    <dbReference type="OMA" id="VYHEQTA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000365679" description="Adenylate kinase">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="1">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <sequence length="256" mass="28329" checksum="5BE65EDBBCDAC511" modified="2008-01-15" version="1">MSNPANTELSYLKSLVNELNEKIAVLEGKAPANQGVRMVLVGPPGAGKGTQAPKILERFQNMVCHLATGDLLRQQVAMGTDLGKQAKKIMDQGALVSDEIMVGMIKDQLETNRSCKKGFILDGFPRTTPQAEKLDQMLSDRKQKLDHVIELQIPDELLISRITGRLIHPGSGRSYHKIFSPPKQPMKDDITGEPLVQRSDDNEEALRKRLATYHKQTTAVTDYYKKHGIWSPIDATQSPNTVWQSISAIFNNGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRL3</accession>
    <name>A8PRL3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732303.1">
        <property type="nucleotide sequence ID" value="XM_001732251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRL3"/>
    <dbReference type="STRING" id="425265.A8PRL3"/>
    <dbReference type="GeneID" id="5856609"/>
    <dbReference type="KEGG" id="mgl:MGL_0078"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0078"/>
    <dbReference type="InParanoid" id="A8PRL3"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="45" mass="5150" checksum="00115E63D859C7A2" modified="2008-01-15" version="1">MPALARGMKVRSSVKRLCNHCALVRRKGRLYVICSKNAKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRN4</accession>
    <name>A8PRN4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732316.1">
        <property type="nucleotide sequence ID" value="XM_001732264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRN4"/>
    <dbReference type="STRING" id="425265.A8PRN4"/>
    <dbReference type="GeneID" id="5856622"/>
    <dbReference type="KEGG" id="mgl:MGL_0091"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0091"/>
    <dbReference type="InParanoid" id="A8PRN4"/>
    <dbReference type="OMA" id="KIHKTHR"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="166"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="230"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="435" mass="47055" checksum="B44BA930204954CA" modified="2008-01-15" version="1">MSPPNESDDVSRISVPSVIDSFLASDKTPMSIQTLPHETAGFPHVLHTSESDKQHVSSADLLHVNPFDSPTQVCGMQEYNVYAGQDLLMQALGMSPSNFNHNDSVSSRTYHAQCSPMLLKPCPGEDDKLQSVNVPESAADLPREIREAASTSATTIPAPSSNTTSSEEAPICSNCGTDNTPLWRRNHNMLLLCNACGLYLKIHKTHRPLLLRKRQQLNSTRASQSQDPCSGPSSGCTNCGTKVTPLWRKGISGAVLCNACGLYLKLHQSNRPVRYRADVIRKRSRYDNRGRISQSEITSPSTPGAAPILPFLSAHLFDPETTPTGSQWNSSSKTPDETHTGDSSMTPNPCGNVASVRRVLQLSDEPFSSPASITCCASSGACTGPVLFNDYQLDDDSVHQVSNSVSGVHTDVDSTLPSILPDVEKHSIWPVFPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRY8</accession>
    <name>A8PRY8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732382.1">
        <property type="nucleotide sequence ID" value="XM_001732330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRY8"/>
    <dbReference type="STRING" id="425265.A8PRY8"/>
    <dbReference type="GeneID" id="5856688"/>
    <dbReference type="KEGG" id="mgl:MGL_0157"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0157"/>
    <dbReference type="InParanoid" id="A8PRY8"/>
    <dbReference type="OMA" id="GRINITW"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF27">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727062" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="4">
        <location>
            <begin position="95"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="196" mass="20477" checksum="C2AC0A99AEEC0F36" modified="2008-01-15" version="1">MYAHKILTTLAVITVLIALATPVHGQGQMAPHKTMIRRRGLIFPDPVSSSSTSQDGPTSTVSSSSTQSSSAPSSTGSSTSSSSGSSSGSVHVRNGDATHYQPGLGSCGKQSDSSEMVVALPHSLFDSKMGGSNPNNNPLCGKKVKASFDDKSIEVKVVDRCPGCGENDLDLSPTAFQKLAPLGKGRLKNMKWHFLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-03-23" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS95</accession>
    <name>DRE2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe-S cluster assembly protein DRE2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Anamorsin homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">DRE2</name>
        <name type="ORF">MGL_0217</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Interacts with TAH18. Interacts with MIA40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anamorsin family.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732442.1">
        <property type="nucleotide sequence ID" value="XM_001732390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS95"/>
    <dbReference type="SMR" id="A8PS95"/>
    <dbReference type="FunCoup" id="A8PS95">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS95"/>
    <dbReference type="GeneID" id="5856748"/>
    <dbReference type="KEGG" id="mgl:MGL_0217"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0217"/>
    <dbReference type="InParanoid" id="A8PS95"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000392393" description="Fe-S cluster assembly protein DRE2">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal SAM-like domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="1">
        <location>
            <begin position="140"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="1">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="1">
        <location>
            <begin position="283"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="1">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="321" mass="34958" checksum="096398602A57888A" modified="2008-01-15" version="1">MNNTAHSMSEKVLLVASLEAARYGQYQQAVKGLQAESGLLETHMIDRITDLAYAPPADYFDAVYMMLPSEGVEWAAALPKLRASMIPGAKLRVSVVNENDPSSFLSQVRAELTIAGFTDIQTYENASIESRRPASSSVAEKDSTASSGMGAVKLRRKPNENGGHQQKKALLWATQPETHMDTEAKLQEHARTVSPASRREDCTVDFSAPRTRRKRACKGCTCGLRELEEEDERNSNLVQLDPSEVGGTGGKRTEVTTTVKGPNGEEHTVRRIQVDTRGATSSCGSCFLGDAFRCSSCPYLGLPAFEPGQKVEIPANMDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSC2</accession>
    <name>A8PSC2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732456.1">
        <property type="nucleotide sequence ID" value="XM_001732404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSC2"/>
    <dbReference type="GeneID" id="5856762"/>
    <dbReference type="KEGG" id="mgl:MGL_0231"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0231"/>
    <dbReference type="InParanoid" id="A8PSC2"/>
    <dbReference type="OrthoDB" id="2413468at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="986" mass="104849" checksum="205E4C4D2A6191C0" modified="2008-01-15" version="1">MPPASHGSPYQVSSPGTAGTTTTHTPVIDNSAWSPPAQRSIPSVPQATSAVTSSAPATTAASSPVSSASPMTSPVSNTPSTAMHERRTISQNPPPLPARVSSPFDKPHELRPARSQNRLQRNPAIVRGRAASNASDSSYQSRTQRPSYPSAHAYAQTRQESMTSDTSSSNDAHVLDTRAAELPLSPDASVHRSAHESSPPSRTGSVRSTHSLRVGPVHTPPPIMRVRSAGGFHDASMRAAVSSPSMDITANAGARGHAASLSPLNIDGKPRLPTSVPTEFSLLSRALPITQRSVSSPMPSQTAPPMERDAPSTMSSPRTPERRLHSQSIDTLMEDATERDTSVEASSQLPGSVAEENRTAIPSTVSSSVSSSSSPASSLSRSGSVSSEYSEDAEQVPLNDPGSASIYDKEDWHASEHERENQGEASGQHASPKGSRDGTDDETHHVRTQRSEEGLALSSSEASDLFAAPKLITSAPSTTSLAQPVSTTDENGLHVDQGEAALGSTHPSPSSLPTPKSQFLTSPQSDTSRMFSSPVDELFDAFASALSDLGLDQPEPMQGLEDVSVSYRDDQYPGGSEGMPSMPSTLESMLPPTGLSSADHKSAPNAGSIQHVPTESKSPAPSVQHLTTPNISGPSQAAQPSLASKDSDAAATETTGTQPEKVLVYGHNVWWPHSFDVSTNLNYDSVAPLQRSRLFADAANDLLSRPSHMGMWVHHVKSQRPNQPDALSRLVIQDQLRELEAALTPRLDEPDGTANVAGGTTRHELPLPTNIPYPLLAKAQSAAHPNPGISLAHQPRYSPRKSQAPSSTLVQSSTAFLMNRFERGKDFLTSSAAATPHSNVTRPLSRTPAQSTHTFTAPADMSRSKSSLRSAALPMGLGIMQRASSHATSADVPAPFSMSARESTSNAALIRMRDALPDIDEATAKNYLLRSQGDDVRAIVRIKDNFIPHAWLCVCLHVLQSEYMADHAQDESTQRRSLFSRTARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSP4</accession>
    <name>A8PSP4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0293</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732518.1">
        <property type="nucleotide sequence ID" value="XM_001732466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSP4"/>
    <dbReference type="STRING" id="425265.A8PSP4"/>
    <dbReference type="GeneID" id="5856824"/>
    <dbReference type="KEGG" id="mgl:MGL_0293"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0293"/>
    <dbReference type="InParanoid" id="A8PSP4"/>
    <dbReference type="OMA" id="RHIIHAH"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="62"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="157"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP45304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="382" mass="42551" checksum="D7059AC7E19AC7C8" modified="2008-01-15" version="1">MAISKTQRKQLQATADAFNTHFSKAYGAERWEHLRARLVEPTEHAALINAYVPSAEIDRALLADAPEPNMYELLRLPPVPTSASSAKNQVPTRLLCLKRRTDHSQAYHSGRPFPPPRPAAASDPQQRLYTHWNLDGASVLAAQCLDVQPGHAVLDLCAAPGGKSITLAQKLWPELYADHPSRTSTTHASILHSNEVDPARLRRLYANLKSYLPNTLMDQGLVEISRIDATSPRAVQLFPLGEEGYDRILLDAPCSSERHILHAYMRAQQSGTAAPEMLAWKPTMSRSMSKTQLALLRTAWAALRPGGRLVYATCSLSEQENDHVVRAFLTSTPEAHVLRTDSLVHFCQQTEYGYFALPDYVIPGTEQRSPWGPLYFCMLEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PST5</accession>
    <name>A8PST5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732538.1">
        <property type="nucleotide sequence ID" value="XM_001732486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PST5"/>
    <dbReference type="STRING" id="425265.A8PST5"/>
    <dbReference type="GeneID" id="5856844"/>
    <dbReference type="KEGG" id="mgl:MGL_0313"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0313"/>
    <dbReference type="InParanoid" id="A8PST5"/>
    <dbReference type="OMA" id="YHPDNYP"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000003">
        <property type="entry name" value="Ascospore maturation 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="218"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="608" mass="63900" checksum="9204951E9AB4DFCD" modified="2008-01-15" version="1">MSTASPSVPTTSATQYGASSVHTAQPQANHGGTPSMHSHAGTTLTASDPHVGHGPGTAGLYQDSVGQGPHHIAGSFAGTQLTPMTSPYGTAAYGTAQHPMYSTSYTGHPYAPYPNYFGHISHYGAHPPHYASAGSSPAYHTPIMSSMIPHSAYNPHAAGHMPSHHAPTTAVPIPMASSSAGTATPAGPSMASNAMMPTSTYGSASQYSAPVPWTGRHRVTTTLWEDEGTLCFQVDVKGVCVARRHDNNMVNGTKLLNVCGMSRGKRDGILKNEKERIVVKVGAMHLKGVWIAFSRGKQLAEQHGIADILYPLFEPNIQSFLYHPDNYPRTAAVMAAAQERQAHRHYGMAGGTSAPVKDVNGNDISANIPLHSGLPHGHWSGSQLAHDTSAASPAGTDASMQYPYAQHHPHYHHQAQAIPPQAHTSASQAQTSTSGSAAAPPGNVFSPPNPAYSAQAMQPAVRPAPTNMMMDRRLDQPSDACGIQPPGLSGAIQAPGNAANTRRMPSLKRSASEHGAQLGDVSHHDEFDQCAGSAAAPSSVVSGNGPRPSTDSFATNALATPNFSLDDMKLEKRQKIESPSVQPSSLDMVYPGESRASEPDSRPQVQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSX2</accession>
    <name>A8PSX2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732556.1">
        <property type="nucleotide sequence ID" value="XM_001732504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSX2"/>
    <dbReference type="STRING" id="425265.A8PSX2"/>
    <dbReference type="GeneID" id="5856862"/>
    <dbReference type="KEGG" id="mgl:MGL_0331"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0331"/>
    <dbReference type="InParanoid" id="A8PSX2"/>
    <dbReference type="OMA" id="VWEEPRR"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="696"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="917" mass="101630" checksum="7394A2D0177262C9" modified="2008-01-15" version="1">MENVESGGGGVDDAVPTYTPADLEQDASRMMEYIQPPLPAETKRMASTDADLRLMSVLLPDVAADRVAALVRTAEAENEQAMMQLQDAENKLRECINEAFILQGEPTDDNDDVSLSLERLATLANTKTAALSRSSSSKNETQQQHSTELAELYAARACTQLLADAEEAMALAHTSSHTQQQLVALVRLATLVEDAQHRGPSASPMLSRTIAILTARRDELNERLRISCTDALRSAMRAAAWPPVAYESPEKFSSNTPRFQLLGHPALERAWTDVCEWQFTAASVGLTKPPTCIQAPATISGVDRLHAMPAAPGSDAYVPLVAVQVMMEPILLRFRYHFDGARPTNRLDKPEWFLAHVVGLIQVHRHLFEPSPDPWTHGGDVAELTRKRSGAMHDAPLRQRYVAVDAPSELLHTLLHPLRQKIQASMERLVHERALLAHNILQLITFDIDLRDTYAPARLVANGHGAVRLADEILGNEAWFQAWVNSERTFAERRFDTLLQAPGAWTLVQSDTMDDEEELPENASDDTAEIDADTTTRCACSLMNMLAGVTERYRPLQLLPQRCAFIIKVQRPLLDVLHNRLVRHLDAFENMSTAFSRALPGDIASFSAGPGSDLVRGEHGVTRVAKALLSAEYVKKQLQEWSESTFFLSMAHDVAGLEKSSPLFRIMTLKISKDDIDSASLVSVLQRGLQRGASAATHLRPLAPSSQASTKGESPYSYESPDTASSNVPGIWDYHISKFDSIATRSAHALERLTVTEVLELLKPYILRRWDRDELGAGPDGVDSVSNLDEQAMRQEVPSRELVPALSKLTKMLQLMVQVLPPNLLLPVYRHIASSLSHAIVERILMPNARFSQQFTAAQAVRFCLDVDQGWLHVVREIDNHPKVAARRSKNAPTGLGRNPELAWRLLIDASKELRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSX8</accession>
    <name>A8PSX8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0334</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732559.1">
        <property type="nucleotide sequence ID" value="XM_001732507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSX8"/>
    <dbReference type="FunCoup" id="A8PSX8">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSX8"/>
    <dbReference type="GeneID" id="5856865"/>
    <dbReference type="KEGG" id="mgl:MGL_0334"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0334"/>
    <dbReference type="InParanoid" id="A8PSX8"/>
    <dbReference type="OMA" id="NKITIMM"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP45345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="427" mass="47622" checksum="BA406643CB57E082" modified="2008-01-15" version="1">MKAMYKLPIFEGVLSDLVNEWRVPRSKSLAYFHGDESVHDFFSRRVGPRIADTFVSAIIHGIYAGDSRHLSVKALMPSLVELEQTHGGILRSFLPKLLNSQYRAPQSTVMPTDQAKMADVESRLNPALVKQLPSTSIYSFPQGLGEIVQALENELIAAPNVEIWKDSACEHIAAEYPFRLTLRHMKEPLYADRIIAGVPSHHLARLLPDLPHLAHNPAAHLAVVDVVLARHDRAASYELPVHGFGYLVPRSAKPNPHDILGVIFDSDAMPNQLEILRSETCSLSSQPFTKLTVMMGGPYWRERASLPSEEEAEERALRALHTQLGIPLTVLSRQVRHVRSRVLTDTIPQYLVGHPQRMQELHTIISTQAPWQHRLSLLGYSYGGVGVNDCIATAMDTCEAISDYELGLDAQPYQRDMTGLKEAARCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT10</accession>
    <name>A8PT10_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0349</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732574.1">
        <property type="nucleotide sequence ID" value="XM_001732522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT10"/>
    <dbReference type="FunCoup" id="A8PT10">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT10"/>
    <dbReference type="GeneID" id="5856880"/>
    <dbReference type="KEGG" id="mgl:MGL_0349"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0349"/>
    <dbReference type="InParanoid" id="A8PT10"/>
    <dbReference type="OMA" id="AIKASWP"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="88"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="537"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="668" mass="74397" checksum="FF18630269464BFA" modified="2008-01-15" version="1">MSENEFINIPSRVNGSDKTRPRAHIDETMYNQMHHRSIHENDQFWAEEANRMISWYVPFKTVQYGDFGRGNIGWFLEGQLNASYNLVDRWAFERPDDIALIWEADEPGSHIYISFSELLDRVCQVAGVLHSLGVRKGDIVIIYMPMIPEAVISMLACARIGAVHSVVFAGFSSDSLRDRVQDSRTRVVMTSDEGRRGGRTIATKSIVDAALKECSSVEHVLVAKRTGAVDVPWVDGRDKWLSELAAQQRTYFPPVSMNSEDPLFVLYTSGSTGKPKGIVHTTAGYLLGAGLSVKHVFDVHPGDRFGCMADIGWITGHTYIVYGPLMNGTATLIFESTPMYPTPSRYWEVVDTHKLTQFYTAPTSIRMLRRMGPEHVQNYDLSTLRVLGTVGEPINPEAWHWYNEVVGRGHCAIVDTYWMTEGGSHMITSLPGAIKSKPGAASKPFWGLKPVLLDSQTGQELQGVDTEGVLAMSRPWPSLARTILNDHSRFLDTYMRPYPGYFFTGDSAYRDKDGYIWIRGRVDDVINVSGHRLSTSEIESALAEHPGVAESAAVGAPDELTGQTIAVFVALKPDYVYDSLEDLTKELSIQVRRAIGPFATPKRILCVRDLPKTRSGKIVRRVLRKIVCNEADQLGDLSTLSDPSVLDHLLVRADIGATAPCMTSRYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT55</accession>
    <name>A8PT55_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732595.1">
        <property type="nucleotide sequence ID" value="XM_001732543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT55"/>
    <dbReference type="FunCoup" id="A8PT55">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT55"/>
    <dbReference type="GeneID" id="5856901"/>
    <dbReference type="KEGG" id="mgl:MGL_0370"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0370"/>
    <dbReference type="InParanoid" id="A8PT55"/>
    <dbReference type="OMA" id="ALTKNMG"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="90"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="285" mass="32090" checksum="621F867ECDF26161" modified="2008-01-15" version="1">MIEAYDASLALKVQRYMRAIDRVRSLVGCLLPRVMLVDTGMVRSWNDVCIRTARGGRPYVERNSSGAHVDFNISHDGDWVVMAFSTCDKVGVDVMETTLPHFEESSTSFCDTMKQAMTADEYAWVRQGASDAEVLSRLYDVWTYKEALTKNMGLGLGFDFARIQVEFWHSKEMPSLRMDDHEESQYRFLEVRLPSGICYQDASPATNLPPNGARQTFTTTCKNRDAVGGRGSQVAIAVGPRACTEQDAAWNCCVSAEQASADGWLRIWTYEAFMEFARHVHEMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT61</accession>
    <name>A8PT61_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732598.1">
        <property type="nucleotide sequence ID" value="XM_001732546.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PT61">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT61"/>
    <dbReference type="GeneID" id="5856904"/>
    <dbReference type="KEGG" id="mgl:MGL_0373"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0373"/>
    <dbReference type="InParanoid" id="A8PT61"/>
    <dbReference type="OMA" id="WIAWHAD"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="439"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="781"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1164"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1458" mass="158836" checksum="800DB41718CBC295" modified="2008-01-15" version="1">MATSAPTFSAAGTPSFCAPAKLKILLVPAAPLEQAEFERWSSYVRVWEHVKLTDVPRTSRPVPSKPLYEQGEVHLSFVTSNDPAHVYLAPFQLHHNVQGVLGLTTYPAKSASDLERVPGLLRSQYPHALLHRVLAFDVHARGQTSKPERDGDMADVSAARSGHSEAETEDDDVGDMGAGADSGAGVGAAATAAGEAEFVPTAGSRGQRESGLVVFPAVRRDAKDVRFYVRTYIAEFVGTLLDHLDTLVAQLDESSLETPRETLTGAPMFKLVTERRLAPPLERRMSAASAASKMFGLKRSKSPAQPPPASLRLVKVKADVAMLNGYLWDALELYDSILTLPGKERALAGGHDAVWFAGALEGWAVTRLLVARLGADAAELAPCLLYPLTPGKDKEVHEPTPPALAWRDIAEAYSLAMAIYSKCLAPPQVQLEALRSMTNETSRDYTPPYVYACACLNYARFLLALFASGGWNSEAFDQLVYGGVPPTLDTGVPLTFAEQAHLAAVSGIYRHEVAAAANAALTPSLPLLLPSDQLRVLSSLHRILSLLGYTRQVAHVSRTLGTVVCSMLVRTMRVRASQGTSSSSSSSSSSVIELSWDSLGDALRWHTPPGPIPIAERIDSGVFACANPALVLGLVACDAYGIDLLTSPLLHVPTTHILEQARRRVCSHAYMDILASALGEKEAKAWLPTLSACAATAWRSRTCFGWHALQVQLLKDLIVQCEALDDHLSQVFFAALLLRDFELDEADQVGGGEGLKHALPRAQWHGAPGLTLRYWGPRSLLRAIQLEPMPASLMPVTRARRDFEPRPQTDASDDGPPGLNNPFIMRTSFRQAASASKESQFVMNEVLTVHVTLVNPWAIPLPLYDVYVRTEGVPVKAANGDSISDGLRARSDATRAAAANSPSSRPPASIHVLVPPRAVHTLRLPLVPLDTGTLQILGLHVRLWGAEPCDLFVPPSIAAIKDNLPRQVGLAARPAAVLVQHVVHTRPANEAELVKTLEPHRAEPLTCRILPQLPRIRASFPELGPSALVLQHGQETRVRVRLCNTSAVPVNFVRFEFEDSWQPSARDAILQRGLLPADVHELEWQLLHAPVISIDNDPEHPESSLAIPPHASKDARFLIRARCDCQWARIRVWYGNTDGNMPSKATLRLRSVTLTLPLSVEPSIDLSSLDVQPIERDVAERLAALMLRRSDSNERQPSSAPEAYGMTSSCALVAMDLYNHSAWPLSVCLDVQAAEHVSLRTHHTLTPGTTSRITFPFSQRHLTQEALSAPIPQLSPRQFVVSQTPHSETQVVQNKAQFWVREALLRSLDATWTNMETGVQGQVTSLRALWPMPVHVPLLVEPSVNVDVTVEECAPADSTLQVCVHVRGARSAHRVRVFLDSCLAKEKASTHVLVADGSWDITYSAYDVQRTGGTFTWTPTLCFLSHGTWTVAAYAQVTWDASSEPFTYTSTSRCVTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT96</accession>
    <name>A8PT96_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0389</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732614.1">
        <property type="nucleotide sequence ID" value="XM_001732562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT96"/>
    <dbReference type="STRING" id="425265.A8PT96"/>
    <dbReference type="GeneID" id="5856920"/>
    <dbReference type="KEGG" id="mgl:MGL_0389"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0389"/>
    <dbReference type="InParanoid" id="A8PT96"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="156" mass="17583" checksum="781ED1BAE5F96DDF" modified="2008-01-15" version="1">MGLVRLASRTLMAPQPILLSPNVVAKYGIHIRAHESAFRENSATIVMPSKEAAFLNPVQEFNRDLSTLAIITWSQIFDCEKRQRYEARQRAREMRARDTSEPDTKRIKTDTKDAKHTYQSYKFKALEALSATGAPQHSICKGNPPPRVSCGQRLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTH4</accession>
    <name>A8PTH4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732650.1">
        <property type="nucleotide sequence ID" value="XM_001732598.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PTH4">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTH4"/>
    <dbReference type="GeneID" id="5856956"/>
    <dbReference type="KEGG" id="mgl:MGL_0425"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0425"/>
    <dbReference type="InParanoid" id="A8PTH4"/>
    <dbReference type="OMA" id="NDVMWKQ"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="9">
        <location>
            <begin position="1807"/>
            <end position="1962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="2096" mass="229829" checksum="0381C027D0C4343D" modified="2008-01-15" version="1">MSSSLASQLAGIRSHNAARLASSSALTARDSYLFTPRAAAEQDHLTVHALGVTGWEQLLDEDAVLASWPHGDLLFGERSIHTDRTTLPKQDNDEIDEAVRELLYLLGPVLLSRSAAKCLEWLIRRFRIHEYTSRELLRAFMPYHHTPQFARMLQVIPIEKYAEWQFLVPVKKAQSSLPTSLLVQALGSNLDVLRWIASNQAPVHVSVRRAHIPFWTSTLVQFCLLHRRANKRRHRADAQAILTVLVPEVLLLLDGTFDEEAVVGALMVLCTLSVAFPLSAKAVRGLIDAVSQLAASSAKPAVARAIVAACISMCASPDDVDDPLSYVATGRGVEESHRLLSESTVRALVQLPEFGAQIARALRTHDIEPFISQLLGSLASDVSFAPARSMLESVLDDDALPRVLSLRTCVSLMLAPHDDAWDARIALLARLRERHPSILDEALSVARNSDEARAWQVIQAVLHMQATGKVPTASDSQDTALWLGVQSADAHAQELALDHLLQAVGRGHVCGNDSLVRDAAETGFARGLVDVLYRHAAILVDAIGPSCLLDTITTRLHDESISAHERDLHLKFVTETLAPRAPALSQRVWRELLWSQLLRCGDGDSDTSARRYRRLIGGFVSCLEHVKEPMAQIASTTAARMSASKEASPLTWTLALSDALVRHLATCDEPTFLDEADFLCNAVIRSPISPGGALALLVIGQLLARALPPRVWVTLAYQATSIVHTQQLLAGQLDDVVMGDKADEAIMQQVLDKLSRRSVRLLGVQLMHTVLQHFPTSSMDASLFMDIQQRTKPLAQLILHMYQTLHAPGVGLTASVKLVPVLFERLDLSTFALLAGLWTTPGGHGQRSLPRQSLSLASLACALEEGSLVPPSSVSVRLMAMRHATLLARAASSKKRALDLQTLLPSLLVVLQDSVPVLRNAAAQLLGALDAWNAACGKDDREVYGFEQVYGVHSAPLQYLDTPTYAKYTSLLAKEAGAFVNDASFLATTHTSILRGSGKKEVLFRTKVLCYLMSHALCLPDLSMRMALFGMVRDVHAPCKLSTALPLVAEAVDAQKPMNPTYLQLLYETYDASAVPVLEDRKTHAFSLFLRSLRSDAPSGLQQVSLDALQHGLFVALRTDDKQKVYLTMAETLADPHVASVPNAGAVLRSFPLSDAVLVSVLRTLCDSLATDDDEPSSKRARSSSSSTSLDEHVQKTAIVLITVLESIQSRTLGMEAALVAALFDVVRTAISLSSTHLFNAEYLLQLAMQSLCNLFDHVTELPTDVAQVVRADTIVSAIKVSTNTQSINHAILLLARFARLDAELVLHNIMPIFTFVGLNVLQRDDRFTLSVVEQTLRSIMPAFVNAVRPQVINDKDARLALWCETRSLLRIFSDASTHIPRHRRHVFFRLLVDVLGADDFLAPVCMLLADRVAHRVSKAPSNSSALMQLPLGLMRAESFPVRVHALNQIWAEVMRLLHGSDDVFLAPVPRREYSDEHLSTLHQVHALLLFLQDAMYNVDPREAEQCADQLQQYAWHTLCLAPPDEVIQNALDKARTPVFQMLPTPTFLTLVLVLLRGQHEAPGVRGHIPSSLSSVQLQKAGLALLQSHAPLTTEERTAQAETLDAVHQALMAIFESHASSQLSMDALGALHTSIMHCVPAEHAHVAALMPQLLAHEAQPILLRALSDMVVRVGVRALSHLSRLVPYACQAVESASSLSRADGARDRDDDLCSAGLSMLTALFKTLAQFMHAYVERVVRLLCHPILQQHKDSSAQTRNAKRKVQDAVVKRMPAATVLEALASAWRDTDVSRTAILHLLQLAVRNMDKSAIATHYKAVYRFVLQAMDEQRHHKTAPAEQAPRKGEAVLPSVLRSVEVFVTLALKLSETQFRPLFLRTYDWALVDLLDQDAPGVQARALTLYTLVNSLFEHLHAMMAPFYAVLVDNALEILQQTLSRDTITATALWHQVARSVRLCAESDEGLFWNAARAKQFVPPLVAALQHETDQDTDGDVLVPATLLALAKAVPEDEFLRTLNTSLMSAASTNDVTSRVRALSVCASLWAGHGMALLTFVPETVAALSELLDDSDPRTSAAALQLRVHIEEALGEPLDSYLESTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTW5</accession>
    <name>A8PTW5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732714.1">
        <property type="nucleotide sequence ID" value="XM_001732662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTW5"/>
    <dbReference type="STRING" id="425265.A8PTW5"/>
    <dbReference type="GeneID" id="5857020"/>
    <dbReference type="KEGG" id="mgl:MGL_0489"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0489"/>
    <dbReference type="InParanoid" id="A8PTW5"/>
    <dbReference type="OMA" id="CEYERVS"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="493" mass="51488" checksum="96CF95C7FD5E15B7" modified="2008-01-15" version="1">MEALEVARAPENELRNGNSHASMNASDHGGTTSAAIASRSHNPRDSSTTKSDGNRSADTSHGNKTNSNKFRCRVAMACVHCRHRKIRCDGAQPSCYTCTRLQRKCEYERVSEQDNLLSRERKRLSRERKAARLAASASQAAAASQPTHGQAQGQPQVQVPTQQLHSARSQQTKHQTIPASSLPTSSDEKNIVSMPQIQPPTSKSTTSPFSLSIPSLGVTHTPTEVAPALIQPPNDPAMASAWSSGANTLVPSKDLMPWAIPPSLTTTDAATLTATNSISPSLSTISGTLPNDALPSLRSTADPSLLEMSAPPSALSDASPSSPTGGLADATSLSPTEPPFGSDTGTTLSSMSAGSLSSEATLVDPLELKTSLDTPLKLFSDQHLPSSMAAATPSSVDSLAFSDSTTSHAFGNKASMATSPLSPQLAPPSFDTIDTGFDHCSLGSFDPDSEEHEAGLGLYSSSLPTLGHTGLGMDLEPSSLPILSSWAHPSSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTX1</accession>
    <name>A8PTX1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732717.1">
        <property type="nucleotide sequence ID" value="XM_001732665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTX1"/>
    <dbReference type="STRING" id="425265.A8PTX1"/>
    <dbReference type="GeneID" id="5857023"/>
    <dbReference type="KEGG" id="mgl:MGL_0492"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0492"/>
    <dbReference type="InParanoid" id="A8PTX1"/>
    <dbReference type="OMA" id="KTTRWRG"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="515" mass="59313" checksum="0BCBD34C1E9C2E53" modified="2008-01-15" version="1">MSSSILARGMRGMFAMRRAPLSPAWTSTRVRSRTVVSTPTPVQTRNEEEPLMPSTASFLPSTDDVARARQLLRWIWLEPTQREELQSFVDRPETSVAPSWFTSTYVTARQYRMARSRLWVPSMERVGGDLNAFLDGEFDAMRIKIERAQDPFLTLDAWDAMDLEEKADVVFQHVWRGMSEEERVAALTRVTFECARRLGWRSGFSSGFPGMPDDAVDPVQQVAKQLRSSGSSKSAVRRALQATEDQRAWDAWQALSPAERRAEWDTAWRQRDRSMIYVDDAPTTRLLGAPAPRWYAVPQRAGSLQFLPNVMVRLVRNYTPRGKPYDVWKATFRVPLNMHKHLLRSYLLAIYGLRTTWARSMVYRSKIVFSATKRRRVVGRGRTFKKVEVGLLEPFVFPSVSQAFLRTHLFSQEMLYEERRLMFKMTKGRRWRGHKSVRDLSRALDNNWAAQSAGAPDEEPVAKRPTAQLLVRKRSVPTARHSNILSVISERRAEREARVQKLLDEQRKNTSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUH8</accession>
    <name>A8PUH8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732096.1">
        <property type="nucleotide sequence ID" value="XM_001732044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUH8"/>
    <dbReference type="FunCoup" id="A8PUH8">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUH8"/>
    <dbReference type="GeneID" id="5856402"/>
    <dbReference type="KEGG" id="mgl:MGL_0689"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0689"/>
    <dbReference type="InParanoid" id="A8PUH8"/>
    <dbReference type="OMA" id="FNCIIAT"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="8">
        <location>
            <begin position="325"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="664" mass="71385" checksum="75CDBF7B1681F22C" modified="2008-01-15" version="1">MRLIVHEGVKAALQAGRPVVALESTIITHGLPRPINYEMAVAAQDQIRRVGAEPATIAILDGRAHIGLDKSQLMRISDSDPARTIKAGRGSLAQVLAQGRGWIGGTTVSGTMALAQRAGIRIFATGGIGGVHRGAESSMDVSADLTELGRTRVAVFCSGAKSILDIPRTLEYLETQGVPVYTFNPSGEFPCFYTAKSGCWVPIMSSVEQAAEVIACNEALQLQNGMVFGVPIPREFESDGDEIQMAVEQAIRESHEQGMDRLGKQVTPWLLRRVGQLAQNSVRSNVGLVLNNARTAAQCAVALAGPQYSSVAQVYDGHGPKKTSQVMVFGCASVDITAQSRQKQMFASSTTPGRIHASAGGVAHNVARATHALIKDKQAVVLVAPMANDVFGKVLLQDMLTVSCMRTDALAPSSHTAICNLLLGAHGELIHGIADMEVVEKSLTPQVVTEKLRQYRPQFIAADANLSPASLAAILLHAKSERITYLYEPTSVKKCERIIEAMQILQQMHMVPIMTPNQYELARMAARIRHVFPRVLNTMQINNLSNSTQLPQELIEDALTMTVVAHTQFIKLGARGVLLVTQNSVGQPYDVNVVHIPATKIPSDKSLNSTGAGDSFAGAIVAHLNTLDTGFYQLTLQDLIQLVHRGQRAAVRSLTSSKAVADEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUL7</accession>
    <name>A8PUL7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732120.1">
        <property type="nucleotide sequence ID" value="XM_001732068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUL7"/>
    <dbReference type="GeneID" id="5856426"/>
    <dbReference type="KEGG" id="mgl:MGL_0713"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0713"/>
    <dbReference type="InParanoid" id="A8PUL7"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="307" mass="34714" checksum="A61802EAF93101EA" modified="2008-01-15" version="1">MSVWNQSHTSAQQVRERGKAVWNHTNIYAGLRERPVPDSHVSHLYGDMTLRGIASDDDSLTTTTLEVAGVHVMRSGRIFLVGTPSTSHDPLDIRHVLGMIPQEEGMFLRNATGQACLADIRARIERLDYVLAHWDSKAPPVLPDQRDPSNCTIQMYAQMMPAGPEHVQTELDLSERELSHPTGLAVVHRAPQFQLNIIGVSSRCGMFVETDTLLGKSRAQFWSDSRYYVAGMICVVFVQLLLMSRECERIQTHTAITRVSGISLFIHANFDAFLCITHTMLAFSSNKFNTPWDVDNWFHERHLVFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUM2</accession>
    <name>A8PUM2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732123.1">
        <property type="nucleotide sequence ID" value="XM_001732071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUM2"/>
    <dbReference type="FunCoup" id="A8PUM2">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUM2"/>
    <dbReference type="MEROPS" id="S09.A68"/>
    <dbReference type="GeneID" id="5856429"/>
    <dbReference type="KEGG" id="mgl:MGL_0716"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0716"/>
    <dbReference type="InParanoid" id="A8PUM2"/>
    <dbReference type="OMA" id="NISHRMD"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="83"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="223" mass="24503" checksum="37885A6F64257EE6" modified="2008-01-15" version="1">MSVSTVARVLAGAAGVTIATLAGLLYVYQTALIYPASFPEGSRTIVDSPSQYGMPYTEHRLVTPDQIKLHVYVIPHEDEQPRPTVLMLHANAGNMGHRLPIARDFFHRLGCHVVMLSYRGYGLSTGEPTEPGLRIDAQTTLDWIRKHAKLSHTPVIAYGQSIGGAVAIDLAARNPETVRALIVENTFLSIPKLIPSVLPMLRHFTFLCRTYRFAAHSPPSPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUP4</accession>
    <name>A8PUP4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0737</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732144.1">
        <property type="nucleotide sequence ID" value="XM_001732092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUP4"/>
    <dbReference type="STRING" id="425265.A8PUP4"/>
    <dbReference type="GeneID" id="5856450"/>
    <dbReference type="KEGG" id="mgl:MGL_0737"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0737"/>
    <dbReference type="InParanoid" id="A8PUP4"/>
    <dbReference type="OMA" id="YIHHERQ"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="14">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="202"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="401"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR633865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="463" mass="52772" checksum="C95D7D457C2902E9" modified="2008-01-15" version="1">MCAQHALNAILQGHFFDPTQLAQIANEIAEFERDELGLVEKNHDAVVSHHVDETGHFSVEVMDRALKAWDMNLARWYPCERLRERHQHPEREFAFLLNLSQHWFALRGFGSQHRQWYNLNSFFARPEWLGDAYLGSFLHQAELEQYSIFVIEPFENTDPPATIADDMADIASASFSRYAGIDGTASEDDEDEALQAAIRSSLEDHSHQVSQQQMPMSKRRNREDFSPDKEDTDESYRHRVWRSPITDSPGSGHRSQRRSLKQRGKQRIVSQSLSQEKQSSPKTSSIVSSSFSEHDILESSSCRTSPFLHPTVAASLLDEDVQDIEEDQQYERYAAPSGFYTLDDDNDAQLQASIALSLGQPCEVPKELLEKTQRALDNRHAPEPIPDDVIRIRNMREQAAAAISKADISSDPHRKRDAPATVNTEERKEEAVHADADFDADSETTQQPISAEEMRRRRLARFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV99</accession>
    <name>A8PV99_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0826</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731558.1">
        <property type="nucleotide sequence ID" value="XM_001731506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV99"/>
    <dbReference type="FunCoup" id="A8PV99">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PV99"/>
    <dbReference type="GeneID" id="5855874"/>
    <dbReference type="KEGG" id="mgl:MGL_0826"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0826"/>
    <dbReference type="InParanoid" id="A8PV99"/>
    <dbReference type="OMA" id="ITHFVYH"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="59"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="181" mass="19725" checksum="3658A676C1601EF6" modified="2008-01-15" version="1">MSDIELLKTKFQYHENWPKQGILFCDVMPVLRDPITFEILITNIMSHIFTQTLPRLAKEGSESRINYVVGLDARGFLLGPIIAQRLGAGFVPVRKRGKLPGECVQATFTKEYGSDVFEMQKDAMPSGSNVLIVDDLIATGGSAAAAGSLVRQMGSKVAEYVFVVSIPALKGASSLDAPEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVI5</accession>
    <name>A8PVI5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731610.1">
        <property type="nucleotide sequence ID" value="XM_001731558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVI5"/>
    <dbReference type="GeneID" id="5855916"/>
    <dbReference type="KEGG" id="mgl:MGL_0878"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0878"/>
    <dbReference type="InParanoid" id="A8PVI5"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="240"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="589" mass="64632" checksum="ABFDF964325EE696" modified="2008-01-15" version="1">MFRPSRAWANDGFEAYRLATASNVHMHVHALPKSVLVHNVHAAATVGYKELKAQSAQKPLAALNNAVAYVASDGSVVQANLHESVASFQVHENPCADAWNGAERMPSVVALDPSTWIVSGMGSSIFVIEEQAQYMIHIPDIPDSEKESRQNRAANLPWYVFQAEAASDHVLFLLQRAFRLRDTHQTGFDIIRVAVCDRQPEILWHVTCAQPIMYAHCHGRQALLGAEVPVSTTDDTGSVPRVPPYTWKQDNQSVTVTFTLPLSVQKQQMHVSLSQQGFRVSLEAPEARIISLDECTSLEPQIVAEESLRRGLYEACTLWAPIHPDDSTWTWEPHAQHHVLALHLAKAHPGTRWPSVFSDDDGVSETLDASELTPMLDRTNKYTSSSLLQDGLEDEDWQNGTSWVISYVDANGLVSQAKDQATFLASSVSKSCLGIDPAILLKYDVDGHVFVPPRAPLSLDAWTHTETVPAISYVLASKRDAHPVYMYRNGLATWLIVIESRPYSAPKHSGSLIYIYGAPGSPRADHASLAPAALAEAVRRNEPPASGLCRVLSIDAGPILDVVVLPNQGERMVCLCESSLLIIDGAFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVM9</accession>
    <name>A8PVM9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731643.1">
        <property type="nucleotide sequence ID" value="XM_001731591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVM9"/>
    <dbReference type="STRING" id="425265.A8PVM9"/>
    <dbReference type="GeneID" id="5855949"/>
    <dbReference type="KEGG" id="mgl:MGL_0911"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0911"/>
    <dbReference type="InParanoid" id="A8PVM9"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="70"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="136"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43434" checksum="A41DA0661E5E517F" modified="2008-01-15" version="1">MIVLAPVAWPTAKLLDYCLGEEHGTTYRKAELKTFVSLHQQIGTENLNDDEVTIIRAVLDLNDKTVADVMTPIEDVYTLPVDHVLDEEGVNKLVESGYSRVPIHENDRPDAILGMLLVKQLIQYDPEDAWPISRFHLTPLPETSPDLNLLDAINYMQVGRSHMILVSRNPGEPSGAMGVVTLEDIIEEMIGEEIVDETDVFVDVHNKIKVVRTRPSGAKQDQWQPLIRGIIERRRKHGGSRQAPLRNSFGTMGSRTPTFPPSQKYGVVQSGKSHDKVSVKTYGQSRAHDSQHDATSQRNTDKPQTPHSMASSLVFSDYEGPELLNLSESEHLEESPGPYIVEKGRGPNEEHRVITVAELNEDTAHDLHNKAVQQAVRQAKDRSRTQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVP7</accession>
    <name>A8PVP7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731656.1">
        <property type="nucleotide sequence ID" value="XM_001731604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVP7"/>
    <dbReference type="STRING" id="425265.A8PVP7"/>
    <dbReference type="GeneID" id="5855961"/>
    <dbReference type="KEGG" id="mgl:MGL_0924"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0924"/>
    <dbReference type="InParanoid" id="A8PVP7"/>
    <dbReference type="OMA" id="WVMLAYE"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="198" mass="21516" checksum="4FC775F1AA76770D" modified="2008-01-15" version="1">MSLQVNLSSPAIRDAYEKVLDGIIDYVVLSYKKLSNDLDVAAATKGSLDDLVDEFSDGKVQYALARVSDPNTKLAKFVLINWCGEGVPENRKGLFAPHSATVADYFKVYHVSIQARSEDDLAPNEILRKVMDSSGSKYGTASSRASEPIAPVGTAHKPVGTPDIRGMQAKAPKPRDDQAPTPVVCSWLFLYPLDLTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVR9</accession>
    <name>A8PVR9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731672.1">
        <property type="nucleotide sequence ID" value="XM_001731620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVR9"/>
    <dbReference type="FunCoup" id="A8PVR9">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVR9"/>
    <dbReference type="GeneID" id="5855977"/>
    <dbReference type="KEGG" id="mgl:MGL_0940"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0940"/>
    <dbReference type="InParanoid" id="A8PVR9"/>
    <dbReference type="OMA" id="VQVTRHC"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="72581" checksum="E7EBCCCBEBECFFDD" modified="2008-01-15" version="1">MDVCKAISVYMERMVKEVHGMKILLLDDHTTPTMSASFTQSALLEHEVYLTEKLSNMHRERMHHLQCIVYARPCAASIQALCQELQHPRYGGYWLYFSNVVSKQHIEALAEADQHQLVQSVQEFFSDYVPVTASHFSLHYDVPPHGLWGSHTVQWDSDAFKHHANALVSLLLSLKKKPVVRYERMSALAKKLADEVVQQTTTTNAQLFDFRRTDVPPLLLILDRRNDPVTPLLTQWTYQAMVHELLGIHNGRTVMHTEKGPQEIVLSVDHDPFFAANLYDNFGDLGASIKEYVVKFQTQSATTTSIETVQDMKRFIEQYPDFQRLRGNVSKHVALLGELSSLVDAHHLLEVSELEQSLASNESHSTDLKNVQTLLASNRISKDAKLRLAILYSLRYQKWSGNQIDAVVRQLIDAGVDDVVLVYVMLNFAGAEHRQDDLFANENIFSRGKSALKGLKGVENVYTQHMPHLVKTIDQLMRGKLRTSSYPFAGRDAPSFDAPATVFPGGPPTKPQDVILFVIGGTTYEEARMIALLNGAASASSSQTPPTPSWPGTHFLLGGTTVHSSQTFLRMVQHTASKLPSSITSPPASIAQRVPHLRLGPVQVAVPQERGDLEQAAIGARDFATGWIGRVMRSVDTLANEQVNRQARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVT1</accession>
    <name>A8PVT1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731680.1">
        <property type="nucleotide sequence ID" value="XM_001731628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVT1"/>
    <dbReference type="STRING" id="425265.A8PVT1"/>
    <dbReference type="GeneID" id="5855985"/>
    <dbReference type="KEGG" id="mgl:MGL_0948"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0948"/>
    <dbReference type="InParanoid" id="A8PVT1"/>
    <dbReference type="OMA" id="YYGFLAM"/>
    <dbReference type="OrthoDB" id="5405745at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="69754" checksum="EB4C442F641CBF35" modified="2008-01-15" version="1">MISASTGISIPTSVVNKNPKPGHAIALNDSQIVRSNLRINASDGLFYTFNTTKDKSVWISLSLCQGPGIPAYNTSDEDLLDRLDKSADEAQHMTLVSMYVSRDKSNPRPGPKTSSSSKYVVYAQGGWTQISLSKGSDQGVYIGVWPPEDPRNVSGEYVIQMTASTKGSLERVDYVPSLFLDDTDRENALLTSFNYTSPAPNISLIVLPTQGDFSLSSITYFNSSFCRIFDLWEEMSFLGIQPFINSSETNRNTLPRVTRGANNQPTALPTPSFENSAKNVSFSTSSNAASNKKRMAALDPGDVTQLELTAVNTTDTNVTEQVLAQVRKQFHVSGLSPGTNYTAYLVSSKDVGESVQRTLFPSVKFVTKTAENCKLMYDLDFCPELAYSVPYNPNMSQVLALQALENIITQNYINFTKTLDTFPCASDKFGLYSSVSTCDDCRRSYQNWLCAVAIPRCTDLVDPEKSAASQNGTELQGLPMPANVHLYPYIVNRVGSNSSRQAYIDEIFAPGDYGELLPCLLTCEMVTRTCPPVIQWQCPRWTVTAQRDYGAFADAGSDGYGVGQNGGAGPDGMRFGGAYTRYVAQDAFGHVYCNAMHVDRLFREASTGAPMRTIMPSWRIWTATLSIYILSALVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWH3</accession>
    <name>A8PWH3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731832.1">
        <property type="nucleotide sequence ID" value="XM_001731780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWH3"/>
    <dbReference type="STRING" id="425265.A8PWH3"/>
    <dbReference type="GeneID" id="5856137"/>
    <dbReference type="KEGG" id="mgl:MGL_1100"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1100"/>
    <dbReference type="InParanoid" id="A8PWH3"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="31"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="516" mass="56169" checksum="76F73341DCE9510F" modified="2008-01-15" version="1">MAGARMPAMGPFTGQRTLQPGMRVRIGTHLVTVRKFLSRGGFAQVYLVEADVPVPVPGHSRDESTLVLKHMCVWTKEALATVRSEVEHHRRLQGHESIVHFVEASAATLVGDGWEIFILMEYCAGGGLIDFLNTRLQHRLHESEVLSIFQDVCEGIAVMHHLSPPLVHRDIKIENVLLTATDTPRFKLCDFGSCFSLLSTKPAVTSEEIQRCEKELNQHTTVQYRAPEMMDLGMHVPITEKADIWALGVFLYKLCYYTTPFEGPGAGPAAILRARFTYPAQPSYSNELRALIDSLLQVRADARPDIDSILARVSRLLTLVAKRAEKRVNAVSIPAPGPAPAPAPPDDALAASTDTSSKAVLPRQPAPVPVVTPPQSRWPQSNAGSSLTRHATISGPSPTRQAARSPGRPDSLVLDVALDDVTARFPSMMDFDKAHAPRRSVRSMVQELDAGSPPRTVSIPMDKTSSNSQCGKPDHTLVDVDLSSSEDEDEPPEDVDTSSPAYHGSASSLPHSCVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWV5</accession>
    <name>A8PWV5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731963.1">
        <property type="nucleotide sequence ID" value="XM_001731911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWV5"/>
    <dbReference type="STRING" id="425265.A8PWV5"/>
    <dbReference type="GeneID" id="5856268"/>
    <dbReference type="KEGG" id="mgl:MGL_1231"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1231"/>
    <dbReference type="InParanoid" id="A8PWV5"/>
    <dbReference type="OMA" id="PRIEERC"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="947" mass="102749" checksum="DF1788C0040FEDBA" modified="2008-01-15" version="1">MPIFSHSTPTPHNVTGSDAETSEANKRFSRRPGVLSLASLSKLGSSQTAQGSGNTHGPASAAAAGAASLGATPPTTPPASAVRNPGVSAVVQADPSRLSQFSLRLNELVNKAFVASQQSVSSIAHSGTSPFTGYSISVPRIQNISYGTNRLPNRIKVIEMTRLVIDELHSAAQEDPYLLRAVSRTVLKTLSQFVARIESQLVSSRTDPTALQIPASLRGPHHVPAAMEFNLALISLEWIVEESLERCLEGLPPLAFLHSPNILMPTAAEGMAQPPMPSYVHDILSPLREQMEASIIHVVQPLLVTLKSSITACLMRANTRPFQPQTSPPLLSDFDAQHGNPRVPWYKELEERLDAAYRLLMLRIVDRCGQDGQAWFISVAIHTIWKGLVIITARSVFAPASVVEAEFAHTFGRTPSAMPSSAVLNALLSGEQSKRVPTPTQLAHALRSVSRHSSSRKWRASVESGSGTRTPEPGTDNFKSWCGHFALPATDADCFVVNPLLVAEQLHDLQVFERLMRQFCTNFYPSLTQKHSCQAHVSEHARDESARVDTSAPESRDVKAHGIESGEQMTAEHKTKENGTESTMADANVKSQDRQSSHGYNLIVSNGVNSDKDVNGDGGKDDDDDDDDLAHEALSEAFEALQCTVIVLRTLLQEPDAMLHMATSSDQGHLEDTGLSPTALHAFRVIPSLLLIQIAFCRIPPGWTDERFPMPAGLELMGNVLPTPPQLFHYSWRDYEAALPGFAAAETAALSLADRYTPIIARITETLNTHLAMSKQEAHVASGARDEGDAGSDYSNEEVPAAMTQSMPMLESTKDPSPLEESANNVNDGHAVGKSGKMPLFSAMNNMAIDDSQAPRSRASTRSVSPLAPRLWRRNASQGPKTALQNALPPRVSRAHATSSFGLSRGRRRSPSPGLPRKTAYTPAHMQRDALHMFDYVLRSVPESLNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX55</accession>
    <name>MDL5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Secreted mono- and diacylglycerol lipase MDL5</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDL5</name>
        <name type="ORF">MGL_1331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Microbiology" volume="162" first="1069" last="1079">
            <title>Secreted lipases from Malassezia globosa: recombinant expression and determination of their substrate specificities.</title>
            <authorList>
                <person name="Sommer B."/>
                <person name="Overy D.P."/>
                <person name="Haltli B."/>
                <person name="Kerr R.G."/>
            </authorList>
            <dbReference type="PubMed" id="27130210"/>
            <dbReference type="DOI" id="10.1099/mic.0.000299"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">Secreted lipase involved in Dandruff and seborrheic dermatitis (D/SD) probably via lipase-mediated breakdown of sebaceous lipids and release of irritating free fatty acids (PubMed:18000048). Shows activity against monoglyceride and diglyceride substrates, but not triglyceride substrates and does not exhibit regio-selective production of diacylglycerols (PubMed:27130210). Cleaves oleic acid from 1,2 isomers of diolein on both the 1 and the 2 position of the glycerol backbone, resulting mainly in free fatty acids but no monoolein is detected (PubMed:27130210). Shows activity on monoolein and liberates mostly free fatty acids, but can also perform the reverse reaction and produce diolein (PubMed:27130210).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731148.1">
        <property type="nucleotide sequence ID" value="XM_001731096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX55"/>
    <dbReference type="SMR" id="A8PX55"/>
    <dbReference type="GeneID" id="5855455"/>
    <dbReference type="KEGG" id="mgl:MGL_1331"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1331"/>
    <dbReference type="InParanoid" id="A8PX55"/>
    <dbReference type="OMA" id="QIWINPS"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00741">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725380" description="Secreted mono- and diacylglycerol lipase MDL5">
        <location>
            <begin position="21"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1 4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="66"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A8PUY1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18000048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="313" mass="35410" checksum="145F3FF1C4455433" modified="2008-01-15" version="1" precursor="true">MQLQYVLTLLWIIFAQNVFSRPTISKVAPENIEFFGRVTSYQKPVKVPDPISMYQQFAGLAQQSNCFKTKINATIGDAQLLFSWGDDDKNQRMQIFRSKSLGIVTSWSGMNVTSLTSLLSAADLFLVDVDRKYFPRVKKGSKLYDGFQNAFKRAAPVLVKKIQYFQELYDEDRVSLTGLSFGAALADIALPYVKENLKRGHIHRVVVFGHPRIGNQEWADSLDTYAEGKFFYVVNGNDIVPHLPPREFGYQQPSGQIWINPSNSSNWKLYPGQENVHGANSIFGFSIKDHTGVYFRTEIGSFWGHCPATIGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXG0</accession>
    <name>A8PXG0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731253.1">
        <property type="nucleotide sequence ID" value="XM_001731201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXG0"/>
    <dbReference type="FunCoup" id="A8PXG0">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXG0"/>
    <dbReference type="GeneID" id="5855560"/>
    <dbReference type="KEGG" id="mgl:MGL_1436"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1436"/>
    <dbReference type="InParanoid" id="A8PXG0"/>
    <dbReference type="OMA" id="CFLYDIF"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="226"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="286"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="58915" checksum="5EB7B28EEC915082" modified="2008-01-15" version="1">MQQLCTFLTQKPAPNANARNGSLIGLAGMGIALGQEIATYLDQMIGPVLACFSDADPKTRYFACESFYNLAKVCKGEMLVYFNEIFVVLARLAADSEVSVKNGAELLDRLFKDIVCEAAPHYVSMYQDVSQLRARQDRDIGVEGGENELQVAREKAAHERYTKAMHLEHDRRSTSMNKAFSLARFVPFLAERMQVVSPLTRNYIVSWIAVLDSVPDLQLVAYLSTFLPHLFQYLSDPNTDVRVATAEVLANFLREIREAAQHQEPPLSGSREASRLSHAAMDKNAPSHVSSAALSAPSASPGSAPSQSNAPVLASASDSAPGSPSSTTFGPTSDPGSHAGPVSDSGPAPTRDLDVHANDDELVWVNGGRVRVEYDAILEILLEQVQNQDEEIQATTFEWITEFLHVVPSMVVPFAPRLISAVLPCLAHPAPAIQSAAIRTNKQLFTAVERLLPNEDAPASNAAEGISNPSAVGGGIGGGLDYFATTHALKQHLLDQHDQARLNALEWLIMLHAKCPTKLFSIHDGSISVLLRALSDPSEDVITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXR4</accession>
    <name>A8PXR4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CAAX prenyl protease</fullName>
            <ecNumber evidence="14">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_1507</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="14"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731324.1">
        <property type="nucleotide sequence ID" value="XM_001731272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXR4"/>
    <dbReference type="FunCoup" id="A8PXR4">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXR4"/>
    <dbReference type="GeneID" id="5855631"/>
    <dbReference type="KEGG" id="mgl:MGL_1507"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1507"/>
    <dbReference type="InParanoid" id="A8PXR4"/>
    <dbReference type="OMA" id="FALCYMW"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 13 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="16">
        <location>
            <begin position="45"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="15">
        <location>
            <begin position="230"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP44110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="361" mass="41086" checksum="50478A2C4EC3E9B5" modified="2008-01-15" version="1">MWEHVTTHIQAAEKFLDTPEIPWKSLITSLLWIVYLFETYVSWRQYRLYSLTTPPKALMAHVSHEDFVKSQRYGRDKARFAFVSDAVAHMVNLASVTYNLSAHVWVWSGYVLDWMKVAHSEKALSGANLVLGLMLQMPVGFILGAYRNFVIEERHGFNKQTWSMYCMDHVKQCLLSVILGVPIMALIVSVIRWAGDAFVVYTVLLFTALILFGTIIYPTLIQPLFNKLTPLKEGMLRDRVTALASSLKFPLKHLYVIDGSKRSSHSNAYFYGVIPGGSKHIVIFDTLIEQSTTAEIEAVLAHELGHWVYAHPSKLLIISLSNNYFTTHSFNRFLSIKCFTVPLLLGFPEQDFLSPNALTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXX3</accession>
    <name>A8PXX3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731362.1">
        <property type="nucleotide sequence ID" value="XM_001731310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXX3"/>
    <dbReference type="FunCoup" id="A8PXX3">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXX3"/>
    <dbReference type="GeneID" id="5855669"/>
    <dbReference type="KEGG" id="mgl:MGL_1545"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1545"/>
    <dbReference type="InParanoid" id="A8PXX3"/>
    <dbReference type="OMA" id="MEYATQV"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="114" mass="12368" checksum="7B309DB5C9299B70" modified="2008-01-15" version="1">MASQVMEYATQVIALLAIYSLLSDLLLLIALVILVGGFTAINRFAPEPMQVGNHVVTQKSLYAILFVVVFVLLWFAQPFALIFWLVGSSALLILGHAAFIEPPVSSEYAGVESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY63</accession>
    <name>A8PY63_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731416.1">
        <property type="nucleotide sequence ID" value="XM_001731364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY63"/>
    <dbReference type="STRING" id="425265.A8PY63"/>
    <dbReference type="GeneID" id="5855723"/>
    <dbReference type="KEGG" id="mgl:MGL_1599"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1599"/>
    <dbReference type="InParanoid" id="A8PY63"/>
    <dbReference type="OMA" id="MDHDPAS"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="9">
        <location>
            <begin position="149"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="454" mass="50714" checksum="4A76692A1DB93F70" modified="2008-01-15" version="1">MASEAKTFGSAAEEARHWKAQVDEMRAALHEAETGLQEFMESSKELEAEMEADMAATSQRADALQTENEHLRADVDEWRTKYQKSLAEHNVMLSELQRELTKLRETHDVYKTRLRDMEVDNDTLENAERYVRDEIKRAVLLTGRMINSSLQDMEMRYHHAMERTALLETELEEKSRLEVENQRLKDELRELREELAVTQQTSPMALSHAAHSPSITSISSAPRPDQGELTLSDLVVKPSSRSSEHDISSSGTAPPDRTAPANTLERLREHMYQLQQRLQRAQISATNTALQRHWQRSSIPRPRSSMSASASGAGGGGQPASPAAWRAPTPSWHERPETPGELRRSMQSSSIPVPVGGLSRSQSRSRPSSRMTHDVQSPIGPVPFQFMEHDPAASPVSSRHSALSRRKSMGAISGIPPPASRARAPSSTRSPSKMPRPVSPARSPTKRTTPIPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYN1</accession>
    <name>A8PYN1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731510.1">
        <property type="nucleotide sequence ID" value="XM_001731458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYN1"/>
    <dbReference type="FunCoup" id="A8PYN1">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYN1"/>
    <dbReference type="GeneID" id="5855817"/>
    <dbReference type="KEGG" id="mgl:MGL_1693"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1693"/>
    <dbReference type="InParanoid" id="A8PYN1"/>
    <dbReference type="OMA" id="LPEMKGW"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13292">
        <property type="entry name" value="PH_Osh1p_Osh2p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="218"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="675"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="698"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1210" mass="133088" checksum="6C062E8C6C48DCF4" modified="2008-01-15" version="1">MDTSRPLPQSDSPLHLAVLCAQPALVEFALFQLQLSPSMPASDTGNTPLHLAIAANRLEVAALLVSQPTVDCAFLNKEGRSPVQLVKSMEMANMLQHQRNELRMHILRLLDAYDAKAARGETGSQEEQTLINTVSMPRTTAIELESVEPRTSLTPLQMAVKYKSTELIKACVAKGCDPYVKGANGCSANDMTNDKMIQALLRQLVHAEASTADNVHHTTSYRGFLGKWTNYMHGFKTRWFVLSDGVLSYYRTPDDEGRQMRGALNLRNLKIVPDRRERNRFEIVSDTSKGSTRWFLRSDDPSECVRWIQILEKAQRNLTQDASASTNAGTDTDAASSDTTGATLMPAAVGSNVPGQGRRSSAVNAEIVEPSSVAMQDITPDSLEDAESDAGSVDGAVAGTNYMPHSKDFTMVNNLMSLHFDVALRLIDQIEGESGSGAQPASAVSTVAPTISGAALSGTDQQVVIPPVERGAPAQPIVGAGLAGAPTVQSGVPATPSSPKLTAISTLRQSLQERSQLWKQYSRMVQEREAYLQEEIERLDRTRHLWEEQVTVLAAQHNELESNLHEAVSENTQMLKGLRQVSQKGALSEEPGSIGDNEPTSSSGISGALGSVVSTVGATAGASAGAATHWISQLLPQKKQEQPSSSSIDDYDDEFFDTIDSDQIPNLRVEPALESAAKENEARASGAERLQEGRKDGASAATGAGAAAGAAGASDSKTDSEEETNKPKDDGKASEDQGGQVAHRSGSEAMFGREFEPYNHLRDRLPVRNDERPSMSLWSILKNNIGKDLTKISFPVAFNEPTSMLQRMSEDLEFSECLDAAALQSESTRRILYVAAFAMSNYSSTINRIAKPFNPLLGETFEYVRPDRQYRYISEQVSHHPPISACFCESPSWEYMGCVDAKSKFLGRSFEIRPTGVAHAKIKVKSDVVPSSMRGKLQQSPDDESLLMEHYTWNKVITSVSGFITGSPTIDHYGDMVVVNHVTGDKCKLTFKPRGWRSNNSYEINGEVIDGQGKKVWIIAGRWNSQLIATRCHSEDCGVLSPDKKHDSSNPVDSSKADHEYLLLWRNSKKVPTPFNLTPFAITLNSRPDGLLKWLPPTDCRLRPDLTAFENGKFDQADQLKVQLENLQREKRRQREEGRLPPHKPRWFKRTVDPDSNESFWQPLMSSDSHGRETMSYWIERSEVGTKREHNQPAEWNTDHIFGDLEAKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZM1</accession>
    <name>A8PZM1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prephenate dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730932.1">
        <property type="nucleotide sequence ID" value="XM_001730880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZM1"/>
    <dbReference type="FunCoup" id="A8PZM1">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZM1"/>
    <dbReference type="GeneID" id="5855239"/>
    <dbReference type="KEGG" id="mgl:MGL_1931"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1931"/>
    <dbReference type="InParanoid" id="A8PZM1"/>
    <dbReference type="OMA" id="YRISREC"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="336" mass="37250" checksum="A6C06CB634E6F1B6" modified="2008-01-15" version="1">MKPETIPSQQIKVLFLGPLGTYSHQAVRKFVQNEPADLVACRSIQEAVTKGAEDARLGRPVVVMVPVENSTLGIVQEALQCLSDPNLFFANGLSIVDEVDLTVAHALIIRALDSSVSNPLSRIEQVRSHEQALGQCSEFLNQHVPQAQRFFSNSTAEAVSYLRQAPAGRVAAVASELCAEMFGMQVIARNIQKSNANFTRFLVVTNREHDRTVAHTLATYRISRECPGNTTHAAYRVRIPIAQRELWVSAIQQTNFPPWMLHGSVYAHVPHVDDETRSYCWLVFELQQCAGPHGDDMKRYPRLSDAPTALLHSALSLPDEVALECLGVWTKPTVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q023</accession>
    <name>A8Q023_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_1973</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730974.1">
        <property type="nucleotide sequence ID" value="XM_001730922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q023"/>
    <dbReference type="FunCoup" id="A8Q023">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q023"/>
    <dbReference type="GeneID" id="5855281"/>
    <dbReference type="KEGG" id="mgl:MGL_1973"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1973"/>
    <dbReference type="InParanoid" id="A8Q023"/>
    <dbReference type="OMA" id="EFAVMLC"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="527"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="231"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP43760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1125" mass="123728" checksum="50D006E06F5AA2E2" modified="2008-01-15" version="1">MGKKKGGSRRDDDDPFADLGEDVTQNNLQPEEPEKKAQESVPNDASNESKGSGAPEKQEHDATPASAGADAGGGGGGGGGDAMQSEPEPPRLLTKKEKERLKKEREKEKKKAQAAQKKASQQKDTQEAPSDKGTNAPGSATQPNASEPTDGSASAQADAKISGDDKGGDADAAAGKDDDDDDEGAEAPSSAADKKKKKKKKKAAPEPAAAPPKKAPNAAIAALQARIAAQKKAEEQARAEEEERRRLIEEEERKEREEEERKEAERLRRKEKEKAKREQLRKEGKLLTPKQKAELKQAEARKAALLASGNISVAAHQAPVPAEKSRRVVYDNKKKKSQKKQEQEQPEREQEQDAKSTAATAPEHQAEPEPPTAPASKEDEKQSAEDDDVKDDWEAESDDVKDDWEQESEEEDTKETPSKGGAPAKDTSAPADRKVEKEKVGQAQTPATSGTNKEKEENGEQDDHDDKEDDDDDDHDDDDDEEDDEEDDDDDDLTKTQRMALERRQAAEQRRKERTEKALAERSADHLRSPICCILGHVDTGKTKLLDKVRQTSVQEGEAGGITQQIGATYFPVDALKEKTFVLNKGEFDFKVPGLLIIDTPGHESFTNLRSRGSSLCNIAILVVDIMHGLEAQTLESLRLLRDRKTPFIVALNKIDRLYDWKATPNNAVQDSLAQQAVHTQNEFDERVSKILLAFNEQGLNAELYYRNKNMGRYVSLVPTSAHTGEGVPDLLQLLVSLTQTRMSRNLMYLSELECTVLEVKVIEGLGTTIDVVLSNGVLREGDKIVVCGLNGPIVTQVRALLTPQPLKELRVRGAYVHHKEVKASLGVKIAAPDLEKAVAGSRLLVCTRDDEEELLREEVMSDLTTLLNSVDKSGKGVCVQASTLGSLEALLEFLRVSKIPVSGINIGPVYKRDVMRCATMLEKARELACILCFDVPVDKEAERLADELGVKLFTADIIYHLFDSFMAYSAEIMESKKRDAAGTAVWPCRLRTIAAFAKRDPIILGCDIVDGSLRIGTPLCVVKADPSTRKKEIVPLGRVSSLEINHKPRNVVLKKDVGAGVAVRIDPDPNEAPKMFGRHLDEKDEIYSYISRSSIDALKEHFWDGVSIEEKRLIKNLKGLLDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q081</accession>
    <name>A8Q081_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="5">2.7.1.36</ecNumber>
            <ecNumber evidence="6">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">MGL_1995</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="26">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="25">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="5"/>
    <dbReference type="EC" id="4.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730996.1">
        <property type="nucleotide sequence ID" value="XM_001730944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q081"/>
    <dbReference type="STRING" id="425265.A8Q081"/>
    <dbReference type="GeneID" id="5855303"/>
    <dbReference type="KEGG" id="mgl:MGL_1995"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1995"/>
    <dbReference type="InParanoid" id="A8Q081"/>
    <dbReference type="OMA" id="QPYRFST"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000046">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="23" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="31">
        <location>
            <begin position="556"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="32">
        <location>
            <begin position="721"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="EDP43782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="838" mass="91245" checksum="AD318CCEE86282A9" modified="2008-01-15" version="1">MVPDPQRYTFATQCATVYDPAHVDQYGASSTPVYLTATFKGLPGAEYDYTRVSNPSRSVLENHLAKLEGAKHAYAVSCGMACLDVIMRMVGPGERVMAGDDLYGGSNRLLELLKKQMNIQVDNIDTSDPIEVERALSQRAKEHAEGHGARVALVLLESPTNPMIKIADLPYCVRLVRKYVPEALVVVDNTMLSPYLMRPLDFGVDIVYDSATKYLSGHHDIMAGVIACNRDDLAEKMFFTIKSVGNGLAPLDCFLLLRGVKTLALRMDRQQSSAMQVATYLDGLGFKVRYPGLRSFPGHVAHMRQARGPGGVLSFETGCTPMSEKIVAATKLWGVSVSFGCVNSLISMPCQMSHASIDPKVRAERGLPENLIRLCVGIEDPSDLLADLHHALLSAGAIEEEPHHSGSFRRVPVKDEMELFRAKLLARKPSSAPKRTTTLTVSAPGKVILFGEHAVVHGVTAVAAATALRCYGRVTPSKQGMVSLSMPDIALEQHWDQAALPWSLYDTSRKLDTLDPQLLEALSMLVSPAYPRDDRRYAASLAFLYLYMHLAQNDALGQAFELRSSLPISAGLGSSAAVSTCLASLLLYTHMHLPLPDLHEPMPKLHTKYINTWAYVAEKVIHGEPSGVDNTVATLGGAVAFTRALPTNHLTENELVPMNLDAVRVLITDTHVIRNTKDLVAKVSAQKNEEPVRVEAAFAMIQHLSTQAQALLRDSTLSRRHLVERLSVLMDLNHLQLVQLGVGHSALENVRRLCAERRLCAKLTGAGGGGCAITLLDDQVDESTVQQLTHAMRAQGFTTYETQVGGPGVGVLVHPNEYASTLGTDAAWANNAGIWVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0A7</accession>
    <name>A8Q0A7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cell cycle control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731006.1">
        <property type="nucleotide sequence ID" value="XM_001730954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0A7"/>
    <dbReference type="FunCoup" id="A8Q0A7">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0A7"/>
    <dbReference type="GeneID" id="5855313"/>
    <dbReference type="KEGG" id="mgl:MGL_2005"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2005"/>
    <dbReference type="InParanoid" id="A8Q0A7"/>
    <dbReference type="OMA" id="TWNNDQP"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="48150" checksum="3E782F3958A03904" modified="2008-01-15" version="1">MLDLRLGKHEADDPTKQEEEDDSMKGQKVKKKPYALQKPANTALRQQRLKAWHPILTHSTVLPLLFGIGVFFAVLGAVMYWSATQVNELTIEYSSCRDEAPRSGVAPADVPAKYYNYRFRHNHDMQQRSPVQWEVEEIPPGPGHENNPPRFQCTLYFMIPEQMGPGVFLYYELTNFYQNHRRYMKSMDYLQLLDKPRTVDQLQKDQCKPLGRDPNSGLAVYPCGLIANSVFNDTFASPVLLDAENAPFRNYSMSEKNIIWSEEYRHYKTPTYNVSEIVPPPFWQGAEGPFGYPSGRYEEGKVFDPSKNEHFQVWMRTAAFPYFRKLYRRNDTDPMTPGRYSLVVEDNYPVNMFKGTKSVVLSTSSWIGGRSLVIGASHISVAALCFLLGIVLSGMQLVRPRRVGDTSYLSWNNPRKQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0K4</accession>
    <name>A8Q0K4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2046</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731047.1">
        <property type="nucleotide sequence ID" value="XM_001730995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0K4"/>
    <dbReference type="STRING" id="425265.A8Q0K4"/>
    <dbReference type="GeneID" id="5855354"/>
    <dbReference type="KEGG" id="mgl:MGL_2046"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2046"/>
    <dbReference type="InParanoid" id="A8Q0K4"/>
    <dbReference type="OMA" id="MCERICT"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="10">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="413"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="917"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1010" mass="111687" checksum="93D8CADD08ADD4C8" modified="2008-01-15" version="1">MASSAPLTLHARCRVANIGYGEILFVGQTSFAPGTWVGVHLDEPRGKNDGSVQGKRYFACEPRCGVFVRPSQVHVQADELEDIPRTSETPHSIRRSVGTSRFSMVAETPQTSRRATAALGPGSTGRTSGARPRPSHFRTPAVINRTPVPASLTPGSIYRTPGTSSRTPAPASQTPGAGNRSPFLSPSERAKTRIEAGRARRLVTGPSPWMGPASQDSDTPQLTSPLGETRSTKPITFQQSPTLSPSPLKEHMTRDNEQKARLEELQTECSAHVARIAALESDASRLSELTQAYDKAKARVRELEGACDELKDNMQELTDSLEMATLDREMAEERSEALQQELKTAQETVEELRLEREIHAESASAALPADAAVLLSENARLKEALIRLRDTAHEADVKQRRELASLRAELVTKEEISAEHTKTLEQLARLEALVSELRAQTEVAQSTEDMLETLAERNGALEELVEKLTTDVRELEALQAVSEELEATHIETEAQLQRDLDMRDEHINALQREQVSMQAHLTAHAATIEQFRALVTDLTRERDTWRAKCDAPPAPAPRAPLTIEQVQTHRPVFAHDRLVAECAMTRRQVQMLRAYALPSFSDVDQGAILTILLYERIGMQSEYIRSALTWSEEGTASWQPRVHDDAQLRVCRLRRAVAHVGALAKQISAVLCSSSPDVFVSRASDHVHMAHLSHQLQAHMEALEDDRLDDATCEAQCKDIVAQLEAVSQALPPCTSLHDLAAKEVGSALLAWHDVETMQACMAFVQHAKVDSSACATWSAVATRARVACRRLYRRLSSLYEQQRQTIQSDSITMLPEVSRLASAMVPRVMPWAYAVLEQRDTSALDAVSTLANDTRTLADLADTVLSKASAQEHVVDIPEAAPWKARAKTLLIACRPVDKSETEALSQRISALEHMLAERDDTVQAASIKIERLRNQLDRSHALAAEVTDARQQVEELKAKLNEAALLPLIILEIHRNSQHLRRSQKTLERLPMHRVLAHSKSCLQITST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0P1</accession>
    <name>A8Q0P1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731062.1">
        <property type="nucleotide sequence ID" value="XM_001731010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0P1"/>
    <dbReference type="FunCoup" id="A8Q0P1">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0P1"/>
    <dbReference type="GeneID" id="5855369"/>
    <dbReference type="KEGG" id="mgl:MGL_2061"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2061"/>
    <dbReference type="InParanoid" id="A8Q0P1"/>
    <dbReference type="OMA" id="WVMDEPP"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="8">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="168"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="9">
        <location>
            <begin position="315"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="661"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="740"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1102" mass="124594" checksum="BE659A97CC033A7D" modified="2008-01-15" version="1">MGGMQVRINDFIYISPPWAIGSGEPYLIARVMNFIQKEDEERCPTKHVRVNLFLRMRDLTHRPNNDPRMLVATMHADVFPVSTIRGKCRVKHRDLISNGSPPEIAAWKRREDHFYYHQLFDRYIHRFYEVVPTWKLKNAPDQVLRVLRERYSFIVAEMTIATELCDALRGCSVCHEWAPTAESVRCDTCRKFFHMRCLSPPLASKPAKGYSWNCAPCAKQHDEMVEEEGVGGGGLDAPGSNMDSLGPRSTQPTRRKRNRSHILGDVYEPVSEMVLSNPIDRDGLRCFQGWPYRYFGEHTSAMDVLDSHDSIYPRAVTRQGPKFQAVVPSWESQQHQNQGRQTSAMDLSNTRTNNSEKAATMRGKSRSKSKHVRSTETHAMDVDQVGTFYETTNDACMQRGSDQSIQVISIPPPDHDWQKVDHYLANVSSPRSHVMRESHVFIDRALALLYANQFDFEKAKHQFAQSRDSDFGVYPLTSKEVQILQKTIIENSGDLIHLKRALPGRTPSEIVQGVYSWKLQRLKDRWEGKERMKITLRGAQPHTDPAQRESSPALSVLSFEDAQEPKAPTRIMCAFCSISASAIWYKSPIYTSGQGLCVYCGQYWRKYAAETANVYITEKKRQAALEHGSEEAGLGVIVPKVTQTVPKVMPAASLPSRPVETSKCVICRRLEPKRLLLSCAQCGLAGHQGCIGFEDADIEKNEWLCDLCENDRDPMSSILPFCVLCGETPSSRTLSTSIRTRKPYFNESDGKGDTALDVYKPTECNHWSHLLCALWIPEVLFANTTTMQPVEGAGALPAWRYDMRCSLCDQVKGACVKCAEPTCRTHFHVSCAYLAQPSCMMAFEIFPVKTSRRESVHTLTFKSESGHMCAQIWCKDHLAAAKSKKTYEYHEIDPKLKLTAMQAYVKTHKQVVTGSHRNMALVESTHALLRRAKKLDIIQQVCGGAGGYVKNGNLVPMHREDHTLKDEMETDAPSDNTTLPSDDKSVSCANCHTDWSPLWWSIPSTDNNKFYLCSHDNTSLHKFITSIVYHVYDIFYHVHLLSGRSAGAESDIVAHHEAFSSTRYLDGISHVSLQVRAPSSRLAWFPSSQARREPSRQGQVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0T4</accession>
    <name>A8Q0T4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2079</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731080.1">
        <property type="nucleotide sequence ID" value="XM_001731028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0T4"/>
    <dbReference type="STRING" id="425265.A8Q0T4"/>
    <dbReference type="GeneID" id="5855387"/>
    <dbReference type="KEGG" id="mgl:MGL_2079"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2079"/>
    <dbReference type="InParanoid" id="A8Q0T4"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="11">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="258"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="548" mass="63203" checksum="EC32F1EDBA2DCE9F" modified="2008-01-15" version="1">MTSQASNVLNDELQERRRIELEVIKSIMLDDFCVHTPSAWHSAPSTQVQTYEAVLRPEIDAQKKHVSVVVRFVLTRLYPNTQATCYVQVNDKRTRGVPLYNLKELEERMNDMARSLRGTEMIWELINMSQEYISAHNTAPPEGTRANLSLEELMRHRALAAEEKAKLRTQEEEQQRNDEEQKRSNELAQRIEHETRRQKQVIKTEIKRLRDTPHFSLPPTTEPGTGEPLRKNDDAAFRINTLLLHEPVHIDGMDIERVRRGPCVAHVPLARTFLCTPFVSEDTLPSDVLWTLEIVPISSTYYMTHAGQRKLSEFEYELTRLRGVHAPALVPLLGWNRRTGQRDDAPSSTSSCPLSLCLVHDYGGSMQLRTMLQQYGTLPCRRVRQILTSLLQALDALHKHKLTHQSISLDAFLFQDGQVRLHGTLYRQRLRDMHRSNPLNTLDGMETDERASMMDGWRAPESLRNPLIYSAARDVWDLGRCACQMLYGEHVTQQFVSPEALFETRVLNSDSSPFLALLQAMMRRSEPATGLRHRNCWRNLISFRRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0V2</accession>
    <name>A8Q0V2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731087.1">
        <property type="nucleotide sequence ID" value="XM_001731035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0V2"/>
    <dbReference type="STRING" id="425265.A8Q0V2"/>
    <dbReference type="GeneID" id="5855394"/>
    <dbReference type="KEGG" id="mgl:MGL_2086"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2086"/>
    <dbReference type="InParanoid" id="A8Q0V2"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12755" checksum="545EAF63AC2B3419" modified="2008-01-15" version="1">MRLAQPDVESKLRSLGFGYRAKFLARTAQVLCERVSCGKDMKPSDVDHAVYTHLLSLRNCTYGEARAKLMELPGIGPKVAEFFFTQTCAHFKSMILMWNTLPTKQQRKWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1I1</accession>
    <name>A8Q1I1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1791</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730792.1">
        <property type="nucleotide sequence ID" value="XM_001730740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1I1"/>
    <dbReference type="STRING" id="425265.A8Q1I1"/>
    <dbReference type="GeneID" id="5855099"/>
    <dbReference type="KEGG" id="mgl:MGL_1791"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1791"/>
    <dbReference type="InParanoid" id="A8Q1I1"/>
    <dbReference type="OMA" id="GDARMHP"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="354" mass="38493" checksum="AFD5D69DA314F308" modified="2008-01-15" version="1">MSFYTHEQAMRSSGDAMSLQGSSDASKAHDADSLNAMHEDHSNIHPAKRLGSLIQQYSRNPSQFQRQFWRHQMNLVENGFDSDGKAIDFFNLGSAPSGNSSALPLARIKKVMKNDDEVKMISAEAPILFSRACEIFIADLTCRAFMVAEENKRRTIQRSDIANAIARSDLFDFLIDIVPRSEMMRHRGSSVPIRNTMPTPSLPSPFPSADVVPRLNMGEAPGQPTNFLPLRPSQPDVRARIDPMEASLGLGSAQPLKGLSKAPMPNEWYPFPTAPMGDARMHPGASLSLSSAAPTAPPSARPMMGRGGVDATAPFMDANASLPMPPPHPRGSLLNMMPYSIDEAASKAHGNSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1Y2</accession>
    <name>A8Q1Y2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730858.1">
        <property type="nucleotide sequence ID" value="XM_001730806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1Y2"/>
    <dbReference type="STRING" id="425265.A8Q1Y2"/>
    <dbReference type="GeneID" id="5855165"/>
    <dbReference type="KEGG" id="mgl:MGL_1857"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1857"/>
    <dbReference type="InParanoid" id="A8Q1Y2"/>
    <dbReference type="OMA" id="QYLPDAH"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26662" checksum="03EC76FE286314F9" modified="2008-01-15" version="1">MYHLVAGLYNELTRKPTYNILLIGFNQSGKTWLLEQLRHTYLKGRAPSDRIASTVGQNVLDLPYQKSVLHFWDLGGAPSMRELWQQYLPDAHTIVWVLDGKQWALDTPVQQETATSYQTAVLDQLFPIAMDAALRGQTVLVLVNKMDAMDPQDVCEDMRPPHVLEHVEATVLKHWARFMDSHASKDIITPHWSFHGVSAVTGYVQRLASSEQALTNIFQRGPRRCACGHVGDSQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1Y9</accession>
    <name>A8Q1Y9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730861.1">
        <property type="nucleotide sequence ID" value="XM_001730809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1Y9"/>
    <dbReference type="FunCoup" id="A8Q1Y9">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1Y9"/>
    <dbReference type="GeneID" id="5855168"/>
    <dbReference type="KEGG" id="mgl:MGL_1860"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1860"/>
    <dbReference type="InParanoid" id="A8Q1Y9"/>
    <dbReference type="OMA" id="VQVYDHH"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="550"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="583" mass="64879" checksum="FFF7FD1B252BEF76" modified="2008-01-15" version="1">MHAVDRRKDDDDSVGDDDDDDDDLPDSNDAFGLKNTLDSERTTRVPERALDATDTAPIVTEHTSAVTQQPASEPLSHTPAATKTLSGTVESTTISDFDFRNQHRTFELFGYARNPSESAAGTASTNSQAFVGDRAAAQSMGGATAAELRGTTADTRHASRQMRRKRKGRTGNASIVDGDGAYVGPWGGWEDEAPRTEFVPAPNTHIGPTEEELRAAHAAAEKRRKDAAALERRRLLDVSHGTEKSIFHGESLYDYQGRTYLHIPTDTDVNLRGEPGSSESFLPEYCIHTFTGHTKGITVLRLFPQSGHLALSASMDTKIKLWDVYHERKCLRTFLGHSNAIRDVTFSNDGHRFLSASYDGQVKLWDAETGACVAAKSFGDVPICVRFHPDEDKQHMFLVGTNDRRIVQYDLRADEITQEYNEHQGPVNTITFVDHNRRFVSTSDDKSLRAWDYDIPVPIKLVADPLMHSMPAVTLHPTQRWLACQAMNNSITVYSAENFKPRKKAFRGHTTAGFACQVGFSPDGRFLSSGDSQGDLVFWDWKSGKQLKRLHTHKDVVIAHEWLPHETSKVLTGSWDGLIKLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1Z4</accession>
    <name>A8Q1Z4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730863.1">
        <property type="nucleotide sequence ID" value="XM_001730811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1Z4"/>
    <dbReference type="FunCoup" id="A8Q1Z4">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1Z4"/>
    <dbReference type="GeneID" id="5855170"/>
    <dbReference type="KEGG" id="mgl:MGL_1862"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1862"/>
    <dbReference type="InParanoid" id="A8Q1Z4"/>
    <dbReference type="OMA" id="FLYDIWW"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="392" mass="43378" checksum="4ACA37840FCF830F" modified="2008-01-15" version="1">MNSSLFLAYGVLLTAASGIVYLGSMASLHTPVSTKALRKQQGLKETDDEEDDLSQGVSSEGAWVFPLLGSSVLVTLFLAFKYLDKDKIVLLVNGYFALAGSLVIPSVLIHLYKMGRGAHSLDAWTNQVLSCNLDLSWKGNAKSTSLIDFHMKWNRMMLYLLGVVIALMAVYLYTKHWILANVIAFCFAIQGMMLISLDTFKTGVILLGGLFLYDIFWVFGSSKFAGQSVMVHVATNFDGPIKILFPRNALEVWSDMSQHGFSSEVAFKFSLLGLGDIVVPGVFAALALAFDQHHASMKSPSLSFDRFNYRFNKPYFNACFAGYVLGLMMTMGIMHVFETGQPALLYLSPSCSLSVLLVAWCRGEWNELWSWVNPASQEPEKPVSSEAVKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q245</accession>
    <name>A8Q245_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730676.1">
        <property type="nucleotide sequence ID" value="XM_001730624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q245"/>
    <dbReference type="STRING" id="425265.A8Q245"/>
    <dbReference type="GeneID" id="5854994"/>
    <dbReference type="KEGG" id="mgl:MGL_2130"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2130"/>
    <dbReference type="InParanoid" id="A8Q245"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="141" mass="15898" checksum="7F5BBA99D1210E60" modified="2008-01-15" version="1">MPFIHNALVLQHEPSGFSYIFDAVRALHCVHGVRDDVQHMAMDCAYASQHTDTNETYHRPRRRLSQSGVQVSYAKKWGESRQHALSSTTASSTPQVSMTKPYDWTYSTTWPGQPGKAAPVDIYAQNAAKTERTIWEPCDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2B3</accession>
    <name>A8Q2B3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730730.1">
        <property type="nucleotide sequence ID" value="XM_001730678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2B3"/>
    <dbReference type="STRING" id="425265.A8Q2B3"/>
    <dbReference type="GeneID" id="5855036"/>
    <dbReference type="KEGG" id="mgl:MGL_2184"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2184"/>
    <dbReference type="InParanoid" id="A8Q2B3"/>
    <dbReference type="OMA" id="FLRTFPY"/>
    <dbReference type="OrthoDB" id="244190at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="203"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="280" mass="31304" checksum="B68B3074E9FEECAA" modified="2008-01-15" version="1">MSVGRGEAAPVALADLALDEATKRFQAIWSSTFSMLQERNRLAHELEASAEASEHTFLRTFPYFGRDRSILKHMHMLLQALDTWKKRMSEGDAAGVPSVDQVESWTDTVSQLMELLAHTGHMMNDPSGAEILHELRSDHAHALDPLYSQTNAALEASEGETRHFSRLDMIQSMNDMPSTSALTSAEPFDTDEDRDTSALLSHNEAWRDQDRHLDHLSASISRQHSISVRMNEELELQSGMIGELDTDVESTGLRLGGAATRLERFRESIKEHGTCTIPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2C0</accession>
    <name>A8Q2C0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730734.1">
        <property type="nucleotide sequence ID" value="XM_001730682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2C0"/>
    <dbReference type="STRING" id="425265.A8Q2C0"/>
    <dbReference type="GeneID" id="5855040"/>
    <dbReference type="KEGG" id="mgl:MGL_2188"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2188"/>
    <dbReference type="InParanoid" id="A8Q2C0"/>
    <dbReference type="OMA" id="KYIQIVF"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF550">
        <property type="entry name" value="MYOSIN-IIIB ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="6"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="378" mass="42138" checksum="D8A8CA978B961657" modified="2008-01-15" version="1">MSAGHAVDEMDHTKMGAADDELVTLLCHRYYQSLYYTQLQESVLVVLNPYRTAVDVNSTEVLHEYRREFRNTRLTQSSSPLPPHVFRLANNAYFYMQRTGQDQCVFFLGETGSGKSETRRLAAHALAGLGTALPGKRGARLALQLPAALYALECMGNVATDENENASSVSLYTELQFSQKGRLVGFKVLNYYLELTRAAVHWDTTSAFQIFSMLVTGASPEEARRWRMTQDTSFRLLEHAHDVAALHTPSTRKYARWLESLTLLGVTAEQRASMLDVLAALLHLSNMDFSDEDGPLCPARVTTEEPLYIAAALLGIGASALANAVTHHTSVVNGQLCTAMLNRERAGRSRDRLMRMLYAQPVRMAQRAHQHVFLARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q380</accession>
    <name>A8Q380_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730535.1">
        <property type="nucleotide sequence ID" value="XM_001730483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q380"/>
    <dbReference type="GeneID" id="5854842"/>
    <dbReference type="KEGG" id="mgl:MGL_2331"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2331"/>
    <dbReference type="InParanoid" id="A8Q380"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="49" mass="5182" checksum="B86B0FD8659730EB" modified="2008-01-15" version="1">MYYIGFVGKALDPRTDSIRQSHVPAEASATHKVDGVGSSHGVSATPRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3G1</accession>
    <name>A8Q3G1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730593.1">
        <property type="nucleotide sequence ID" value="XM_001730541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3G1"/>
    <dbReference type="FunCoup" id="A8Q3G1">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3G1"/>
    <dbReference type="GeneID" id="5854900"/>
    <dbReference type="KEGG" id="mgl:MGL_2389"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2389"/>
    <dbReference type="InParanoid" id="A8Q3G1"/>
    <dbReference type="OMA" id="SEAWESH"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="323" mass="35888" checksum="43A35C5CCCDBCC06" modified="2008-01-15" version="1">MKPSYGMLSRWGVVSYADTLDTVGILARNIGDVRQVFDVLALEDERDATCIHEAMRLRLDAQVERILARIPSRLDGLRVGIVKEMYPREVDSRTLDIVDDVLDHMQSLGATLVPLSVPAIKKSVSAYYILSLSEASSNLGRFDGIRFGARMKHTSSTFHDEIAKNRSYGFGDEVKRRILLGTYALTSEAWESHHLVATRIRQGILRGYQACWSTQDLRWPEPTGNEEHGVDVVVQPTALSVAPRLDEPVSSEYAADVLTFAANLAGLPALSAPASRTISMDEDPSVHLPVGVLFKAQWGHDKLLFHILEQLNQHTDVFQGPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3H7</accession>
    <name>A8Q3H7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730609.1">
        <property type="nucleotide sequence ID" value="XM_001730557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3H7"/>
    <dbReference type="STRING" id="425265.A8Q3H7"/>
    <dbReference type="GeneID" id="5854916"/>
    <dbReference type="KEGG" id="mgl:MGL_2405"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2405"/>
    <dbReference type="InParanoid" id="A8Q3H7"/>
    <dbReference type="OMA" id="YLYNQYT"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31067" checksum="31CEBCFF67F7DEF3" modified="2008-01-15" version="1">MAFSIARFMRQGAQAVRTYASVASAHTSSSLAPTGKTPHNVLNTKGPKRFAYQDKRKGFSERKTFLFKKYERLLRENELVLLFKMENLDVKLLNNVRRQASLVKIPSEDLARLEEKNNGVPWNFPTCSLTMIRTGLMRPVCRKDTAQPVQALEPHLRGQLAMLTCPVLSPEYIGKVLRAMERPVAAAVDAHDPKSAKKAPLFKPIVAVAERSRLVDTNALPAFTKLPNLPTLRAQLVGLLSAPGQKIAGLLSQAGGGELAATLEARRRDMEKPGTSAESASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3J6</accession>
    <name>A8Q3J6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730628.1">
        <property type="nucleotide sequence ID" value="XM_001730576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3J6"/>
    <dbReference type="STRING" id="425265.A8Q3J6"/>
    <dbReference type="GeneID" id="5854935"/>
    <dbReference type="KEGG" id="mgl:MGL_2424"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2424"/>
    <dbReference type="InParanoid" id="A8Q3J6"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725094" evidence="1">
        <location>
            <begin position="17"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="524" mass="59039" checksum="3B08EF2FFB579A61" modified="2008-01-15" version="1">MRTSLVWLIHALLSVAGPVSSPAMHLDHHICTEIARSLSEAIATSYDRLPMFPVSPSAPHHEAWVYERFPASTVRWPVSTCYESSALGTFIDSLWLIQSIWCICSSCIKPDPLADQLDILVTSVLEQFKTLFVQPCLQRALDKCYAAAESMCAMLYYTDILYSVLEPCTPLSRCLWVQNDERCFADIIHKGLQDSSSHTLAYALRAAQTWSRWTSWHDATPGTRPLSEPHSCMAFSLVAMAEQLQVPKNRASFSHRFLMHLTSVEQTMRDDPMYYDVPGTNRRSTYKPLDVFQPHIGPGEYFLQPLTKLLRHWFSAPLEQNIRVIDAFASLCRSPLLNIDGLLHADSTTPPILTFYLYMLYNQCLDFHHHMPDFSFYLSQRKVQCLGTPLPEKYQPDYHSACPLFHSLCPESGIDSMEQSFRQASWIPPDLSHTTSFTIRTSTSDQSQVSTSSLDGALHIVVSVSPCSAPASGPWYDPAVYGVEDVPLVNILDNVILLEEVLLEMACTASLRHAWGIDRPCSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3Y7</accession>
    <name>A8Q3Y7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730098.1">
        <property type="nucleotide sequence ID" value="XM_001730046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3Y7"/>
    <dbReference type="STRING" id="425265.A8Q3Y7"/>
    <dbReference type="GeneID" id="5854400"/>
    <dbReference type="KEGG" id="mgl:MGL_2480"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2480"/>
    <dbReference type="InParanoid" id="A8Q3Y7"/>
    <dbReference type="OMA" id="MIPLNGH"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF38">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="245"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="419" mass="45302" checksum="EE5D9806762CE39B" modified="2008-01-15" version="1">MKPIQSPKGSASGSSSAWQGRKRDQNQHASPSLGALESLSNTMQEASSLSMPSPALSPATLAINKRGGVSAPNRPPSGELSPSLRSTKFASGESNASIHNLSTKSPSPIELAQNSDQTQHSSQPATPGSLMGLVYAPESSKAQRKAEPSHVQTPSHPSHAQQHMSQPLRTYQQPSDFSSLHTYPNQNAVHAVTASALINAARPHASLMYPNSSSQPKFILPSGLSSEDRSTWLGFRHLEQGGLEQRRSSHKAAEQKRRDSLKHCFDELRALLPAITIDDNVPGGSVLGADGTKEDRIAEGLELEDSSKAENEAEPTSASGFASPDQCRDANRIVAKVLLLRHSNEYLVRLQRRIERRDLALHSLSEEVVRLRSLLNQRGISTDGEDAKVSNEMSSLSIEPEENSPAIKPEDAPCWLGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4F1</accession>
    <name>A8Q4F1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730151.1">
        <property type="nucleotide sequence ID" value="XM_001730099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4F1"/>
    <dbReference type="STRING" id="425265.A8Q4F1"/>
    <dbReference type="GeneID" id="5854458"/>
    <dbReference type="KEGG" id="mgl:MGL_2533"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2533"/>
    <dbReference type="InParanoid" id="A8Q4F1"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="242" mass="24889" checksum="17FEBA955F22EC18" modified="2008-01-15" version="1">MMPATSSTAASSTPTAGTASPSVPTSASVSTATPAAASAMSLAQPLPGALDALSSGAPTTSFASTPTAHGPIGAMAAVRPELGEVAAVAAAAATASRMNGRLSRRDDRKKNAHSKMLPGEAVDPTMSRGNVGSMASHGGGGGGASGTHGGPRRSDMDLSAMQLHDLQGEIPQLCRDQFGCRFLQKKLDEGIPSQCDQIFAETFPYFAELMTDPFGNYLCQKLLEYCTDAQRDRSSKLLQAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4U4</accession>
    <name>A8Q4U4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2640</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730258.1">
        <property type="nucleotide sequence ID" value="XM_001730206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4U4"/>
    <dbReference type="FunCoup" id="A8Q4U4">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4U4"/>
    <dbReference type="GeneID" id="5854563"/>
    <dbReference type="KEGG" id="mgl:MGL_2640"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2640"/>
    <dbReference type="InParanoid" id="A8Q4U4"/>
    <dbReference type="OMA" id="HEPRIER"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="167"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="14">
        <location>
            <begin position="400"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="574"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="704"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="741" mass="82329" checksum="7B47C80CCDEF4870" modified="2008-01-15" version="1">MEKTNFCEGKGKVYMTHPTKAIYRFLMSDFVRISNAGSDRMLFDEAEMLASWRQIEAVDYHQEVVLGGGLRFTPYHAGHVLGACMFMIDMAGLRVLYTGDYSREEDRHLVQAEVPPMRPDVLICESTYGTQSLEPRLDKEMRFTSLIHSIIRRGGRVLLPVFVLGRAQELLLLLDEYWEAHPELHSVPIYYASSLARKCMSIYQTYIHTMNQHIRARFHRRDNPFVFKHVSNLRSLDKFDDKGPCVMMASPGFMQSGISRELLERWAPDKRNGVIVSGYSVEGTMARDILSDPDDIVALNGQRIPRRMSVDYISFSAHVDYTQNSRFIDQVKAKHVVLVHGELKNMSGLRAALQSRYSDREEEIHIYMPRNCEPLTLSFRADRTAKVIGSLAAHAPKPSDTIDGLLVAKDFSYTVLAPEDLTEFTGLGTSTIVQRQRVALNVGWDLARWHLQGMYGHLDEGVDEQGLRCMRIMNVVDIKLARPGMLVVEWESSVSNDMVADSAMALLLGIDSCPATVKMTMNEHACSHAPTARGASASHVDTVESLLALLEAHFGDLEMMDIGGGVRVTDVHAEPSTHSAKEQMLGGMPEHGSDARETHETGATDASAHASDAAEAHADADQGEADSPLDRLCASIPGPVRVGVKVELDAEPIIISLDDLSVFCDAEALRHRAERLVAMALSTSQSLADTFHLTPACSSMLFQGKHSHEMQDQDHDDQDGAHHDHAELPVHPKTPIKALAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4W2</accession>
    <name>A8Q4W2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730273.1">
        <property type="nucleotide sequence ID" value="XM_001730221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4W2"/>
    <dbReference type="STRING" id="425265.A8Q4W2"/>
    <dbReference type="GeneID" id="5854578"/>
    <dbReference type="KEGG" id="mgl:MGL_2655"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2655"/>
    <dbReference type="InParanoid" id="A8Q4W2"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="115"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="380" mass="41579" checksum="9AD98999A7EA5432" modified="2008-01-15" version="1">MKKPRLSDPTGANTSTSVEAAPSMRSASTNVPLSDASANTSATACTIDDPVAGSCPGHGLCNGTGGSSECSGCPTYNNVKAEVVEAPTSSSYTDSSLPTPSSTSSKTLADAKSGPIEALRCTNCQTTTTPLWRRDEDGNNICNACGLYHKLHGTHRPIGMRKTVIKRRKRLMGSGSSSNQLQAQQQKQASLQNSKPMSHAKCSDAEAPVRPEREREAAMVLMEVGSSRWPRAPSMSPPRSSDEAVEWPYAPSHEVPLSTHSARPFPPMTYAPRVSFGSRFKELERLRDELYMERTRINELLEHTEQTLLEWRHSRFNVMNYTSPYSVPSLHTSALEEAPRRPRIPYSPAARAMDHGADDVPEISRLTPPPPSWRACERMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4X2</accession>
    <name>A8Q4X2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA dehydrogenase/oxidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730281.1">
        <property type="nucleotide sequence ID" value="XM_001730229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4X2"/>
    <dbReference type="STRING" id="425265.A8Q4X2"/>
    <dbReference type="GeneID" id="5854586"/>
    <dbReference type="KEGG" id="mgl:MGL_2663"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2663"/>
    <dbReference type="InParanoid" id="A8Q4X2"/>
    <dbReference type="OMA" id="EQPVMRQ"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="75"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="204"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="306"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53025" checksum="3308EB6CFB1EDFAE" modified="2008-01-15" version="1">MFLHAHGSETVLTHDASSGLHSIEVLTRESTKKLVIGQVEDQQPQVHYPKPGDFSKVPYAEPTWLVEPFASPYYSDSHRRLAREMREFTDKYVMPVAEKCEATGERPDVDLVKRMGANGLNPMRLGPGKHLAGRKLFADIKPEEFDYFHEMIITQELSRCGCRGFMDALQGGMVIGLPPVLNFGSDEMKKDIVEPVFRGEKFIALAVTEAFAGSDVMGLRTYARKTEDGQHYIVNGTKKWITNGNFADYFTTAVRTDEGFGVILIPRELGVETRLIHTSYSPTAGTAFVMFNNIKVPAKNLIGQDGMGIPIVLSNFNHERWVMVCGTVRGVRGICEILMKWIHQRKVFGRPLTSQPVVRQKLAFLIAQAEAAQAYLEQITLQMNKMSYKQQARFLAGPIALLKAWSTRVSHETADSAVQIMGGRGLTRTGMGRKIENYNRGYKYDAVLGGTEEVLADLGIRQAFRFFPKDHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q503</accession>
    <name>A8Q503_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GPI inositol-deacylase transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730305.1">
        <property type="nucleotide sequence ID" value="XM_001730253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q503"/>
    <dbReference type="STRING" id="425265.A8Q503"/>
    <dbReference type="GeneID" id="5854610"/>
    <dbReference type="KEGG" id="mgl:MGL_2687"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2687"/>
    <dbReference type="InParanoid" id="A8Q503"/>
    <dbReference type="OMA" id="SATIRHW"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="3">
        <location>
            <begin position="319"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="817" mass="92060" checksum="A0BFD8E51EBC22AF" modified="2008-01-15" version="1">MVDPAWCHPIWTNGLEYLPYSPAKEREPGTKFPDAHLQYDVPSISLSRLHLSAAFLHKYEIDSVRIEYTVNPAEFPTSENVSSILTYGWTEDKPLVLRGTPGWFRSRTWELPGLNVSSLLSSYVEHGPLWEWDLPDIDSALLAYTFTLVPAPCASRFHPPPPVMAPMVRFISASTGDVRIFPSLRLHESNHLHVALHGVAPFMQEPKHRGTRLQFWLLDEYIGTPFSGTFDSTCPLPYASIHASIHWRASIALLVLRYRLALLVWPLGILALARIQSSHSPSAALASLTHGRGLLIVLLAPIALHVCVFFGASLGVPRHTLGIGITSLHFWWLGPVLAMTALSLAMLMHVVVESLLCAWYILVRRLAPRYLPLPTQPTQLKQAPRLHTWLAWTRQPSTWLAACVLTAFLVFMPYQVLILLCTIVHMAATCSSYMAFREAERHASLNDTAGVLRARHAEHLWLLHFLLWLLPLQAPMLVVWVRNVNAGLTMGFTSIQYKMWAVAPLLWLIYLFWVPWTLSPPAFHSLGFEHARHVVYGTMSLCALLYGVRYGYFVLDAFVVTVLYELIARIAPLYMRPPKPEAIPMNGTSRLNVPASLLNKDAACPTVLRPPGDHTDHLWEEYLDTLDAYMHARAQAEQAMKQGFAQLTRAKMALNGGVFGQRLGRDLYDERMSARIRIQPETPGATPSIAQPLARESASTESNPATLRRRLIREKEPHDVKHPDTKPGCSSSREDDPDHDEHPTTRHPQGFDPLFQFSGLPPRSLKAAQREFQRALGLLLDTNASTKPVEPLSHNVWRLQNRLYSLETELHARRNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q507</accession>
    <name>A8Q507_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_2690</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730308.1">
        <property type="nucleotide sequence ID" value="XM_001730256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q507"/>
    <dbReference type="FunCoup" id="A8Q507">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q507"/>
    <dbReference type="GeneID" id="5854613"/>
    <dbReference type="KEGG" id="mgl:MGL_2690"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2690"/>
    <dbReference type="InParanoid" id="A8Q507"/>
    <dbReference type="OMA" id="ESLDCCM"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP43094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="540" mass="59460" checksum="1194029E66E9EC8D" modified="2008-01-15" version="1">MATRSYAAAIDALNSLQSNAATIEAIRKSGKTVNELNEPEMTEYLERIGHSRDELDRIHVVHITGTKGKGSTAAFCDALFQKIKGLLSYSSGDRRIGLYTSPHMVAARERIRIDGAPLSEADFAKFFWEVWDRLENNPHRALASTPIRPVYFRFMTLLAFHVFISLKVSATLLEVGIGGMYDSTNIVRCPIVTGVTALGLDHTAILGHELKDIAWQKAGIYKTGVPALSVEQPVEALDVLRKYAEEKVHASTFHVVHTYRELQQVRLGLAGDHQYSNASLALELVRSFVASGIGKECFPGALDILGPVGERVPKAAQEALASTFWPGRCQIVPAKEAFHATYFVDGAHTVESVRACVQWFVRETAGNTRPKVLAFNCTNGRSAHTLVQAMLDELRQCDEDSCTFFQRIFFCTNNTYADGGSASDLTSRAIDPKDLESMAVQRELLHAWCDLQGITQRDALSAFGGNTSMRDIRVHVMPTIEHVMNAVREYAQSTHTVPDVFVAGSLHLVGGFMAHLQAKGALDERLRSTQNLDPATKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q512</accession>
    <name>A8Q512_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730312.1">
        <property type="nucleotide sequence ID" value="XM_001730260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q512"/>
    <dbReference type="STRING" id="425265.A8Q512"/>
    <dbReference type="GeneID" id="5854617"/>
    <dbReference type="KEGG" id="mgl:MGL_2694"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2694"/>
    <dbReference type="InParanoid" id="A8Q512"/>
    <dbReference type="OMA" id="YNLRNFW"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="351" mass="39784" checksum="A184E6A62F9CCFBB" modified="2008-01-15" version="1">MSGVNNDAIQACLELILQSPPGQQSHIVSDLKGMLAGAVPDTEWMERVRSILLQYTHEQLLHVTIEHEGKQDSAIVCDAAKMDDKYYHPRLSCSFSYDPIHESVSEVSSVPRSTGDIETLRAEVDQQLSKYVLNHYHTGVSCAYLPRLVPQATSDANAETVTINAMQDKQKEKENNLELWDEANQEQPVQQMQGRVDNCDSQVTSENDTPPAITSQPCILTLHIVGNKYNLRNFWTGRWRSTYKFDVSTQAFKHADIQVQTHYFENGNVQLQAQHSMALPDFVSTKPESLAKDVIQAIEHHEQVYQAKLFDATDTLREHAFKALRRTLPITRQKIDWSKIVSYKVGSDMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q560</accession>
    <name>A8Q560_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730349.1">
        <property type="nucleotide sequence ID" value="XM_001730297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q560"/>
    <dbReference type="FunCoup" id="A8Q560">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q560"/>
    <dbReference type="GeneID" id="5854654"/>
    <dbReference type="KEGG" id="mgl:MGL_2731"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2731"/>
    <dbReference type="InParanoid" id="A8Q560"/>
    <dbReference type="OMA" id="MDIPRPE"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="489" mass="55450" checksum="4CB01797B8A29E1D" modified="2008-01-15" version="1">MSVVSDKPQHRIEASVLSQTFWIDPAYKIKKGLGQGAYGCVASAVHVASGESIAIKKVSNVFNKRILTKRALRELKLLRHFRGHKNITCLYDLDITNPSAFNEVYLYEELMEADLHAIIRSGQPLSDAHFQSFIYQTLCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLSRGFDPEQNTVMSGQQEFMTEYVATRWYRAPEIMLSHQNYTTAIDLWSVGCILAELLGRRPLFKGHDYVDQLNQILYYIGTPPEPMLCRVASPRAQQYIRSLPYKKPVPFEHLYPEATPLALDMLRRLLSFDPEQRITCDEALEHPYLAVWHDPNDEPVCANKFDFSFEQVDDIDGMKKLILQEVISFRREVRLQAQQRLAMMEQHQQQQQLQQQFYANQMGSSSASSSASSAEAIRRREEAQVAASRGTIQKSSSEHATYNILGEPMSADGTPKDVGDVAVAENDAAEYPYGAYMLADFDSDAFSRQLNQHHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q585</accession>
    <name>A8Q585_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730368.1">
        <property type="nucleotide sequence ID" value="XM_001730316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q585"/>
    <dbReference type="STRING" id="425265.A8Q585"/>
    <dbReference type="GeneID" id="5854673"/>
    <dbReference type="KEGG" id="mgl:MGL_2750"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2750"/>
    <dbReference type="InParanoid" id="A8Q585"/>
    <dbReference type="OMA" id="PEMVPHA"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="177" mass="18681" checksum="F11C479A6EEA9427" modified="2008-01-15" version="1">MLPHQQNKIDISSLTEEEQKLFRLYGKLPNRKDLVANKLKERKYFDSGDYALSKAGRAPKQSVGTTIPNPEMVPHAAYPSHPVQTPGMFVQGSGLGGATSGPNVPTSPGASNMMNVPSSPSGGHRTSVGSGSFTDTGSRSSFPMATGVMAGSPSREPTSSLSREQMPDPSSSNAMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5H0</accession>
    <name>A8Q5H0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729791.1">
        <property type="nucleotide sequence ID" value="XM_001729739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5H0"/>
    <dbReference type="FunCoup" id="A8Q5H0">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5H0"/>
    <dbReference type="GeneID" id="5854110"/>
    <dbReference type="KEGG" id="mgl:MGL_2777"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2777"/>
    <dbReference type="InParanoid" id="A8Q5H0"/>
    <dbReference type="OMA" id="SHRHGEY"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="223"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="443" mass="50324" checksum="E71B2D0AA6644F46" modified="2008-01-15" version="1">MSMHPSVYGRAGPQRSTKSALKHKILPEEPERNTNGGPGAEDAYADLYWDDDADVDTEDMAHLHHIPEGNMRRDALRLTRKARSRLPRVTAYSTATSYKLPELIRWLQARKSSHETNVVRFDECVYTTYTYHHVDEARGLPTTSPWVLQQGRPPFRLDSSRTPTGDLLGVPELRQESASPEHGLQTISEENEGGVDVSKQEEPEAAPKSPRKSTQLVHYVPEVFLMEYGTIVIWGMSLTEEKRLLREIRKFEVERLAPEDVECEDLSWYLADYSRIYNDVITLRRGSSYMTRLSLSHALAQSAKISFFESVIEATIDTTKDIPRSIAESGKVGMPPVDIMKNIGHLFILRMNIHLVGSVVDSPEIFWSQPDLEPLYAAARSYLEIQQRIDLLNIRVEVLQDMLQLLKDQVTSSHSEWLEIIVIILIVLEIFLGVATSMSNILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5Q6</accession>
    <name>A8Q5Q6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="9">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729819.1">
        <property type="nucleotide sequence ID" value="XM_001729767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5Q6"/>
    <dbReference type="STRING" id="425265.A8Q5Q6"/>
    <dbReference type="GeneID" id="5854126"/>
    <dbReference type="KEGG" id="mgl:MGL_2805"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2805"/>
    <dbReference type="InParanoid" id="A8Q5Q6"/>
    <dbReference type="OMA" id="TQDAQWP"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="10">
        <location>
            <begin position="10"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="10">
        <location>
            <begin position="549"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="768" mass="86227" checksum="234A8C283205CF76" modified="2008-01-15" version="1">MEQGLFDATQQAEAKDIIGNISKLKYEMTHDRALSPLGVTASNASRIGSFFAPSTEPYDDLIERTKPTWYKSDWLFTECYLYRRLRHIFERSAKWRDFDPFLELKNNAFRASGLGIYACAVWMHELLSQSQTHAASSHETQATFNDLIYSSLWGNATDLSLLLQVDKEELQKLQVDSEHERNRKLQHVLVNDVDAVWRKLRSVRHGRVDMVLDNAGFELVTDFMLAEFLLTLRGPIPSASEERANDIEGRIYRIQRRITETCQQQNLPKKPRLLVVSKLQPPSALMAAYDRTGQRHFGENYVQELIEKARVLPDDIQWHFIGGLQSNKAKLLAAVPNLYAVQSVDSEKLALGLEKTLAKPEHASLRKAPLYVYIQVNTSGEAGKSGVPAMDAPWDGNSSNKPPLLSLAQTIMLACPHMRFSGLMTIGALTNSQSVQGHEERENPDFLALVKSRKYLAQALEQDSEFQAKLSNTSFWAPQGNLQNVYGTLREHDLELSMGMSADMSSAIAMGSTCVRIGNDSFGARTTNSEAASVREAELDACTDVPLIKEVVFHTKNMPWFVSDACVPDVWRMLDQLSQPSFFADAPSFPSLEPVHAMAQRWHMYFSSGQFRLAMPHDAPLGASVNDLSDYWTWPDSYGLLPERAPNLHRELQASDLVIFKGDLNYRKLTQDAQWPPTTPFIRALGPLAGTTNVVALRTCKAEVCVGLKEGQATELDACDSSWRTNGRWAGTYEYPAHSRLSRGEVRLITHTIGTVIQWADARLQRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q613</accession>
    <name>A8Q613_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729854.1">
        <property type="nucleotide sequence ID" value="XM_001729802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q613"/>
    <dbReference type="FunCoup" id="A8Q613">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q613"/>
    <dbReference type="GeneID" id="5854161"/>
    <dbReference type="KEGG" id="mgl:MGL_2840"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2840"/>
    <dbReference type="InParanoid" id="A8Q613"/>
    <dbReference type="OMA" id="YYYFGKK"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001985">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="242"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="526"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="758" mass="81836" checksum="8E69B13EBB3BEB13" modified="2008-01-15" version="1">MSAAKELPSSSAPGSRATEELEVSIRPTSSSVAADTRVLVRADALKRSGIPTGAYVVVLQAQTRKSLCAGTVWPDFDEENSRGASLCPLLVDASEARGRVIVQAVHAAPAMARIGIRLESELEPPMHMELVRALLLHTLVDAGAVLLGSVLRMSLLGQTFLAHVMDPSQGASTSGQVVIVTRDTKIELEIRPETADTYPDALVDASAYQALGGLDAQIATIRTLVELPLTQPHLFEQYGLTPPRGVLLYGPPGTGKTSLARTVALSLQAHVQTINGPELSSVYHGETESKLRSIFENAASHKRSIIILDEIDALAPRRDASAAVHAEGAGEVERRVVATLLTLLDGMASTHVVVIAATNRPSAIDPALRRPGRLDREIEIGVPDAPARQAILQVLLRRVPHSLRDEDVANLAARTHGYVGADLAALVREAGMLTITRRIHKPVHESLASLSLSHDAEKVAMPDFHAAQNIVRPSAMREVFVETPKVTWDSIADDENDSLSIKRQIQECVEWPLTHAASFARLGIDPPRGALLYGPPGCSKTLTAKALARESGLNFLAVRGPELVSKYVGDSERAIREVFRRARTAAPSIVFFDELDAISGIRGTDTSAGSSDRMVASLLTEMDGIDAESHVVVVAATNRPDCIDPALLRPGRIDRLLYVGPPSTTVRERILQMRTRRMPIDEGVDLQAIAELAAGCSGAEVVAICQEAGLRAMKEDVACTKIAHRHFEEAARTMQRRITPAMLLHYEQWRHRMLSTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q660</accession>
    <name>A8Q660_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2857</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729871.1">
        <property type="nucleotide sequence ID" value="XM_001729819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q660"/>
    <dbReference type="FunCoup" id="A8Q660">
        <property type="interactions" value="586"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q660"/>
    <dbReference type="GeneID" id="5854178"/>
    <dbReference type="KEGG" id="mgl:MGL_2857"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2857"/>
    <dbReference type="InParanoid" id="A8Q660"/>
    <dbReference type="OMA" id="YLYQITR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000711">
        <property type="entry name" value="Probable cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="297" mass="33763" checksum="39AD15C6349450D7" modified="2008-01-15" version="1">MENYQKIEKVGEGTYGVVYKARDMTPGANGRIVALKKIRLEAEDEGVPSTAIREISLLKELRDENIVRLYEIIHQESRLYLVFEFLDLDLKKYMDNVANQPEGLGPEIVMKFTYQLVRGIYFCHAHRILHRDLKPQNLLIDKEGNLKLADFGLARAFGIPLRTYTHEVVTLWYRAPEVLLGSRHYNTAIDMWSVGCIFAEMAMRTPLFPGDSEIDEIFRIFRILGTPNDEMWPGVQSLPDYKTTFPQWGGVPLKTVVPSLSDAGVDLLGLMLIYDPAVRISAKRALNHPYFASVTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6D4</accession>
    <name>A8Q6D4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729944.1">
        <property type="nucleotide sequence ID" value="XM_001729892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6D4"/>
    <dbReference type="STRING" id="425265.A8Q6D4"/>
    <dbReference type="GeneID" id="5854251"/>
    <dbReference type="KEGG" id="mgl:MGL_2930"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2930"/>
    <dbReference type="InParanoid" id="A8Q6D4"/>
    <dbReference type="OMA" id="NEWESEH"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="729" mass="78549" checksum="D01DE966BF1CF0AB" modified="2008-01-15" version="1">MDSVDPPPPFTSQECRVPTEQALPPAPSLAPRPTSEPGSHEEAEPGSAPVPPPHSPPPAFASEDESSNDESDHQEARRPAPMDPIKMRESDAWERDRLLGYSLEERVARMERRRLGEPHASSTHHPFSTVSAQPETLHWTRARDTTERDPSTVLHIAKAPAPICTPSSFDDATSPDSSDSSGDDCPAPAGDDSDHEWRSEHDALQALYRYESDMREVYKQGHMYAHRNDRFGQAKQEPAEHTSVTDEQNFASLAMSPRRPGTSIAVDLERAPLSQEQHVRPASTQDPASTSDVAPGRVAPVGVAQESESCPPQHHGDGARGPTSDMECAPDQLESDLASSALRSHAHRSASTPSQQRLLASLTRASAKEERSEGPMALSEDPAVERPNLSVPASSSAPVDQASESSRMQRNTLMSGNRQDHSRSSHPPPPAPPSHVPMIRSAYDQLRVLQAANQLPPSLHQDLLSLESYLSQYETPTETASLTRSMSHFGGAFTSARSSTAPLPAQTHLPVVTDETRHFPPSRLSSDAGAVSSTPPKSPSTTPTQSVPESLRPARLASEHLLSASAINTRAALASQASMNPEATALASLTGQHAQEEQRTTALESCGPRHVEPAASTRAEPEQNTEAAPVSQESQSLVVSTDDADSGAALLAQLAPRAVPQEEITDLELAVAQLDSPSTQYEWASLISDFLGPAREQTRLSPEDLERISVGRVELEHRRVTASGQVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6F5</accession>
    <name>A8Q6F5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_2951</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729965.1">
        <property type="nucleotide sequence ID" value="XM_001729913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6F5"/>
    <dbReference type="FunCoup" id="A8Q6F5">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6F5"/>
    <dbReference type="GeneID" id="5854272"/>
    <dbReference type="KEGG" id="mgl:MGL_2951"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2951"/>
    <dbReference type="InParanoid" id="A8Q6F5"/>
    <dbReference type="OMA" id="YFGWARQ"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000001">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="15">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="333"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP42751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="395" mass="43027" checksum="E1D8A0E7A457325D" modified="2008-01-15" version="1">MSTLADIKIFCGSSHPELANLICKRLGVPLGRSSVTKNDAGELMVRMYESVREHDVYIINTSCVTYDQDGRPVSPNTSLMELLIMINACKTASARRVTAVIPHFFYARQDKKDKSRAPISARLIANMLETAGCDHVITMDLHASQIQGFFNVPVDNLYSEPAALQYMREMLDINRVVIVSPDAGGAKRATSIADQLGVDFALFHKERKKANEVSRMVLVGDAKDKIAVLIDDMADTCGTLDLAAERLKESGADRVFALVTHGILSKPALERISKSSLEMLVVTNTLPQAANKEKCAKIEEIDVSHILAETIRRSHYGESVSVLFSQVPYDTVQPYRRGADTPTHSPPRSATSSPSHPSLSGAVLDKRLGVLSGSEKDHAATVPSPLRQVSSGQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6H7</accession>
    <name>A8Q6H7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729984.1">
        <property type="nucleotide sequence ID" value="XM_001729932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6H7"/>
    <dbReference type="FunCoup" id="A8Q6H7">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6H7"/>
    <dbReference type="GeneID" id="5854291"/>
    <dbReference type="KEGG" id="mgl:MGL_2970"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2970"/>
    <dbReference type="InParanoid" id="A8Q6H7"/>
    <dbReference type="OMA" id="SHVAKIM"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="767"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="963"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="774"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="796"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1013" mass="112739" checksum="27F1DD076EC9D81E" modified="2008-01-15" version="1">MRGLSRYISELQSCSSLEEEHQCVRREMIHVRSKLISSGSKSDRYEQKKSAAKVIFTRLQGFPVDGISLEPYALMSSPKYSEKQMGYLAWTTCFADCPEVLVRALSIVQKDLASLNESDTCLALQAVSCMSSRVLARQLGEEVLKLLISHTSSVPVRKKAACVALSFYRMDPSFVDLAEWLDRIAPLLEHPQLGLAHCACLLAMELVRNAPSSFSLFYKHAIDALSAILLQNDVRRDYVYHRVPAPWLQVQLLALLRLYPRQPVLDADYKIKLHDILTFIWKQDVALAAKADVHEANARYSVQLEAMRLVVHLDASSPLVSRFTSSLGQLLTSPETNVRYLSMEIMAHLAQRIPSLSPINLHRDVIFVALGDTDISVRRRALDLLYAMCDRTNVRQIVRRLLDYLVVAEPSLRQDLTLKISILAELHTSESSWYIDTTLELLHVAGRHVSNTTWQRILQVVTNHPKVHVYAVEQIIMYLQQALCHDSLVKLGAYLLGEYGYVVANRPGCTPMDQFQLLTRHMLSCTAMTQAMCMTTYAKWAGMYPEMQTTLLTTLQRYVHVLHMETQQRASEYAQLILLSMREKLDLQDVLDELPPFNESQLGGTNASVNGILEPNRRVSAVPVVSSVRRGEAKYTQNDASSRHRLPALTSVLPESTYTAPVATIAPVPVANTTRRSVSSVLSSPDHSSLLTSSPTVYTGDLSMDLLDLQSLHMTSPHTDVPEQPWATNTGMVDSSQALLTEQTTKTASSLPLNHSCHERHESHEQKCSRTFFPSPSHSPWHSPSQSMLPLATQQSPTRSPLRSLSESSSHPVPSPPSPTQFLSRSRSWTLPQSLSLSPPPASTSPTTSSIPVPAPAVSVALPFLPSPLTNTPASPAQRPCSLPSTTGSLHHLYIDMPFMLLFAERGTLHETKTERLTFARERPKATMRDARILCTLSITNKTKSTLLHIQDVHVHGPVQSRVITPPVESPSGSKRPTTVAPQGTKGISIEFACVKPFVDTPQVDIEWRQARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6I5</accession>
    <name>A8Q6I5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729991.1">
        <property type="nucleotide sequence ID" value="XM_001729939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6I5"/>
    <dbReference type="STRING" id="425265.A8Q6I5"/>
    <dbReference type="GeneID" id="5854298"/>
    <dbReference type="KEGG" id="mgl:MGL_2977"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2977"/>
    <dbReference type="InParanoid" id="A8Q6I5"/>
    <dbReference type="OMA" id="LGPDQIY"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="353" mass="40351" checksum="B20A3D65CBB46B6E" modified="2008-01-15" version="1">MQARSYWEQNGQCDRVHFRPVIFPQTNPSLGHCGYLSACHRKTTCKYVHYEIDTSPPHAPFVWECTSSKPYAIDSDEAKYASIHGPYTQLKRMGMDAWLHSALWDSLRSPFVAQWIDCDVRDFDLSSLGKFDVILADPPWDIHMSLPYGTLSDEDMHALQIPALQDEGLLFLWVTGRAMELGRHLLRQWGFVRIDELIWIKTNQMERLVRTGRTGHWLNHSKEHCLVGIRGTKANTYRSACAAGQLPPLLPWMHAGLNTNVMVSQVRETSRKPDELYAMIERICPGGRKLELFGRRQNIRPGWVTLGNQLKSTHVVEPILCRAVDVYQAKQCSRTHCFPAGDSLKNATLEHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6Q3</accession>
    <name>A8Q6Q3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730045.1">
        <property type="nucleotide sequence ID" value="XM_001729993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6Q3"/>
    <dbReference type="FunCoup" id="A8Q6Q3">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6Q3"/>
    <dbReference type="GeneID" id="5854352"/>
    <dbReference type="KEGG" id="mgl:MGL_3031"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3031"/>
    <dbReference type="InParanoid" id="A8Q6Q3"/>
    <dbReference type="OMA" id="WIHMLLE"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="543" mass="58602" checksum="B2B08255EB79A0CF" modified="2008-01-15" version="1">MTNERASLDLASLQQQLQKHRSSLSDAILSHLPSPSASSPPASKQSPVDVRRPATLGVGATTDGGKSAPIHPSDQKFRAKLGARAGQKREHASSSLNEPQDGSDIDEEADTRSSVPRKKAPQKTSDIFAAAEAKAKAAHTKAPPRPVPPDLATMSKAQRKKWNKRQRIAESVSNASDKTPSLRSSQSPPNALASSEPSPVPTQGIASGSGEDVQNASTQLDSHHKVPVPLLESSSSSSSSSNMTPLQSSMLASLQGARFRSINERLYTHHSSDALAFMKNEPQLFDDYHAGFRQQVRKWPTNPVDRIADLLIRTKKSHADRYPIRASNLPGALIVDLGAGEGGLAKKLAPHGFHILSYDLVTTADGWVRGLDAAAIDALPLPGVFAPLGLVWHHATSAAMVDVAIFCLSLMGTNWVHMICEAWRVLKPGGELVIAEVSSRFGSTGETLAFTELVRALGFHLDWQDSSNTHFVLLKLSKTMDYRQASQEALSPIEHTMVSNTRTKVDPLALRHAVAQPAQAQDVLDLLVRSGAQILKPCLYKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q777</accession>
    <name>A8Q777_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729767.1">
        <property type="nucleotide sequence ID" value="XM_001729715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q777"/>
    <dbReference type="FunCoup" id="A8Q777">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q777"/>
    <dbReference type="GeneID" id="5854073"/>
    <dbReference type="KEGG" id="mgl:MGL_3311"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3311"/>
    <dbReference type="InParanoid" id="A8Q777"/>
    <dbReference type="OMA" id="VMIWIHV"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="396" mass="45550" checksum="EE90918F749A7D80" modified="2008-01-15" version="1">MPSDTSNWIISVPVQEEKSQEQMLQDMVTRLVRDSACDESDVAPLRIPSLKTGTLESLIIMAEDLPKIDNLFAAIVSRIVDALRALLNDDEDALNENLNIDGMSVEDYVMSWQWNSGKYRIEKSLNELMELLTKEMQSIDHIMKQKLSSYSAAKGQLQQLERKKHGNLTVCSLADIVHKDDMVDANSEFLVTLLVVVPKNHAKDWLSKYERLTPMVVPRSSSELAQDDEYILYNVTLFKKFQDEFIQKVRENKFHLREFVWDEGLLAREREELEEAGASEKELWTELLRLSCINFAEAYQALFHFKVIRTFVESVLRFGLPASYFVTVIEPTPRKAKTIIKSLVNQFSYLNEYISSKEKNAPAPSTQQHETPGEFVNLLEQEVFPFVLTEQSMIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7Q3</accession>
    <name>A8Q7Q3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729549.1">
        <property type="nucleotide sequence ID" value="XM_001729497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7Q3"/>
    <dbReference type="FunCoup" id="A8Q7Q3">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7Q3"/>
    <dbReference type="GeneID" id="5853855"/>
    <dbReference type="KEGG" id="mgl:MGL_3093"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3093"/>
    <dbReference type="InParanoid" id="A8Q7Q3"/>
    <dbReference type="OMA" id="ATWGGMF"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37296" checksum="D87F8C54C037AAFB" modified="2008-01-15" version="1">MLFSTSLVVIVGRTPGGQRKLQILNTKRQSTICELSFPSDILTVRLNRRRLVVVLATSIYVYDISNLKLLHTIETGVTQDGLCALASVSDECYMVYATTHKLHDHNAGASSSVVVYNLHSLTMVNVIPAHRTRVVCLALNSNGTILATASEKGTVIRVFSIPDGRLMYQFRRGTYPARIFSMTFNAASTLLCVTSDSDTIHVFRLFVSINRPLSSTSDPKHALEQKRRSSLALASSWSPVSSTPTTSWRQRGFSMVHALGTYLPTSLAEMWEPTRDFAWLKLPKPGVRSVAVVSNSQPVVLVLTYEGLLYTYALDLDLGGECHLTKRTCYLHVPLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7W6</accession>
    <name>A8Q7W6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729600.1">
        <property type="nucleotide sequence ID" value="XM_001729548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7W6"/>
    <dbReference type="GeneID" id="5853906"/>
    <dbReference type="KEGG" id="mgl:MGL_3144"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3144"/>
    <dbReference type="InParanoid" id="A8Q7W6"/>
    <dbReference type="OrthoDB" id="3357587at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="66" mass="7890" checksum="C9D05237C9572E0B" modified="2008-01-15" version="1">MSRWPRVFEQMLTAYATAALARWMGRSPFFLRITERALHEWDHLPHRLRGHAVPPFESQTRDTKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q829</accession>
    <name>A8Q829_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729646.1">
        <property type="nucleotide sequence ID" value="XM_001729594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q829"/>
    <dbReference type="STRING" id="425265.A8Q829"/>
    <dbReference type="GeneID" id="5853952"/>
    <dbReference type="KEGG" id="mgl:MGL_3190"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3190"/>
    <dbReference type="InParanoid" id="A8Q829"/>
    <dbReference type="OMA" id="GSYEGWK"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="9">
        <location>
            <begin position="71"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="179" mass="20356" checksum="FBA61D03D9363A7F" modified="2008-01-15" version="1">MTLHHSKHHQTYINNLNAANKAFAEAEKNGDLRKQIELQSAIKFNGGSHINHSLFWKNMAPQSEGGGQLHDGPLKQAIEKEFGDVEKFKTNFNATSAGIQGSGWCWLGLSKGGHLEIVTTKDQDPLVTHHPILGSDIWEHSWYLQYKNDKASYFKQWWNVVNWKEAEARYNEAIKKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8F0</accession>
    <name>A8Q8F0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SMC hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3259</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729715.1">
        <property type="nucleotide sequence ID" value="XM_001729663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8F0"/>
    <dbReference type="FunCoup" id="A8Q8F0">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8F0"/>
    <dbReference type="GeneID" id="5854021"/>
    <dbReference type="KEGG" id="mgl:MGL_3259"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3259"/>
    <dbReference type="InParanoid" id="A8Q8F0"/>
    <dbReference type="OMA" id="GQKTVCA"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="10">
        <location>
            <begin position="521"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="673"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1169" mass="132237" checksum="39F574F488EE0A47" modified="2008-01-15" version="1">MFIKALKIHGFKSFRDADSITSFSPGLNVVVGRNGSGKSNFFAAIRFVLGDAYASLSREERQALLYDGSGAVSTTLSAYVEVTFDNHDGRFPANGDEVVLRRTISLTRDDFLIDRKSATRQDVTNLLESAGFSTNNPYYIVPQGRITHLTNATDAERLDLLKDVAGTRVYEQRRAQSLEILRTTDMRYNGSADLLAQLDARIDELAKEQSELEKFYARDRERRCLEYTIYQRELADVSEMLESLENERRRDVDESNTRREEWARYDQARAEREARHSQLLQQLEQVSLDQAQLEQERRELSRSQAQLDNSLDDLDHMPDGGRAALESQLATLRATMAERESQLQAQTDEHVRVMRELESHRAAFERDRTRMSALYAKQAHAARFSSIEERDAFLQAQLAELDTEAASLDAATKEAQEACAAAQAQHEQHTAERCEFEEQLANRGTTLAAMQEQWRTLHDERNALLEHKKELWKQETKTSSQLTHAKDQLSTAQRNLVGMMDRATAAGLQSVETIVAREQVQGVYGPLYQLFRVDERYKTAVEATAGASLFHIVVDTDETATTLLSLLQQEKSGRVTFMPLNRLRPPDTQYPHAPDAVVMLRKLSFDEHLLPAFKQVFGKTIICPRLDIAAAYVRSSQGLNAITLDGDQVDRRGALSGGFHDPSRSRLDAVRRVQRWLGEVDVLEAQLTQQRQDSHELEQRVTQMYSDMLRLEAQRHQLQESRAASQHELTWLRRSESDSLARKERLEQAVSERSVEHTALKTRRQVLEAEIGSPLDQGLDTHEAKELRLLLAQQQHSEETLASLTRTSVALSESTSALRSELDECLRRTFDALQARLDRMDDRPSSATAAALEQSHATNAARREAVNQQYDTLAAELAELEKTMDASRGTSDEQADDVSRQHVAAERWAARKQRMEEQRSRINERIRDLGVLPEEAFQKYQKRSTEQLAAQLQRVRASLDEVAHVNKRAVEQFHSFSKQRDTLLQRHKDLAASHASIDELVEVLDARKAAALDATFHQVAAHFTEIFAELVPGGRGRLVMHNGIGVSMDVSFHAGQERMRMTQLSGGQKSLVALALVFAIQQSDPAPFYLFDEIDANLDTQYRTAVAQKVHALARDAQFITTTFRPELVERGDQHYGVLFGQQKVSSIVEITRTQAREFVEAAADDTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8H2</accession>
    <name>A8Q8H2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein axonemal assembly factor 5 TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the importin beta family. Importin beta-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729726.1">
        <property type="nucleotide sequence ID" value="XM_001729674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8H2"/>
    <dbReference type="FunCoup" id="A8Q8H2">
        <property type="interactions" value="828"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8H2"/>
    <dbReference type="GeneID" id="5854032"/>
    <dbReference type="KEGG" id="mgl:MGL_3270"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3270"/>
    <dbReference type="InParanoid" id="A8Q8H2"/>
    <dbReference type="OMA" id="AQEGAMS"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000028">
        <property type="entry name" value="Transportin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="11">
        <location>
            <begin position="176"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="466"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="834" mass="92517" checksum="128ADB5597D08FDF" modified="2008-01-15" version="1">MATSWSPQPEGIAELVELFRQSTSTEREVQRRIAHRLDAISQIPDYLNYLVLVFVQMTNEEISTRSVAGLLAKNHLYFNSQRVSPESLEFVKHMILPALSFSDTVLRNVASQIVAVLMQVLKPANWIEGLSSLTQAMDSSHTEEAEAALSTFAKISEDMPEELDACEIQGMRPLDVLIPKLLQATAHTDTRIRVHALNSLNQYIQIGSPSMNANMDGYIAVLFQRATDERPVVRKFVCKALVYVLTTWPEKLAPDMNNVVEYMLYSTQDKDEDVALEAAEFWLQFSEEPRLVEQLRPNLPRIIPVLLKCMVYSELSLLMMGDIGDDAAQPDRPEDIKPRHYGGTTHRSEHMESSDATTHKSRAAIDVEFDEEDANDGDDDDEDDFDDDDDFDDDDEAGSWNLRKCCAAALDVLAVQFRDDILPTLLPLLKDRLFSDDWLQREAGILALGAVAEGCIDGMTPHLPTLVPLLVNTLQDPQPLVRSITCWTLGRYSNWCAGEAIEHQQQYFVPVLEGLLSMVLDNNKRVQEAGCSAFATLEEEVGQALAPFLSPVLRALVMAFDKYHQKNMLILYDAVGTLADSVGPALNQPEYIDMLMQPLTARWASLDDTDPDLIPLLECMASVTIAMGPGFQPHAVPVFQRCVNIIHQNLVAYEQAMTQPSTADDELPDRTFLIVALDLLSGLCQGLGVQSQELVANVQPLILPQLLPCLTNIEPPVRQSAFALLGDLAINAFPQLKPYLPTHMPLILSQISPEQMHETLSVCNNATWAAGEIALQSHSDPDFQVWVPELLTKLMAVLMHPKCVKSLSENAAVTIGRLGLVGHTHCGAAAACVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8W0</accession>
    <name>A8Q8W0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729312.1">
        <property type="nucleotide sequence ID" value="XM_001729260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8W0"/>
    <dbReference type="FunCoup" id="A8Q8W0">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8W0"/>
    <dbReference type="GeneID" id="5853610"/>
    <dbReference type="KEGG" id="mgl:MGL_3347"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3347"/>
    <dbReference type="InParanoid" id="A8Q8W0"/>
    <dbReference type="OMA" id="ANWRFVE"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="4">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="155" mass="17329" checksum="A832CD28A55A9D8A" modified="2008-01-15" version="1">MGNQRVSFKRYVEVGRVVLVSNDESKNNLATIVEIVDQNRGVIDGPSTGVPRQVMAFRNMNLTGFVIKVPRGAGTPVVKKAFEASGVKEKWESSKWAKTLKAREARKNTSDCTLMALYFAWDTCADRLLVDRFRIQVLKKQRRSIIGAAAKKVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q953</accession>
    <name>A8Q953_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="6">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="6">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PRT1</name>
        <name evidence="10" type="ORF">MGL_3414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729379.1">
        <property type="nucleotide sequence ID" value="XM_001729327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q953"/>
    <dbReference type="FunCoup" id="A8Q953">
        <property type="interactions" value="809"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q953"/>
    <dbReference type="GeneID" id="5853686"/>
    <dbReference type="KEGG" id="mgl:MGL_3414"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3414"/>
    <dbReference type="InParanoid" id="A8Q953"/>
    <dbReference type="OMA" id="LWGGPQF"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000947">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="716"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="759" mass="87724" checksum="379A9BE0CDD57732" modified="2008-01-15" version="1">MADASTSTSTAQQQQQQHRMDPTSSVEDIDFSDIEAKYEVHMDEGLDNDIVINGVPIVTSAKEQRLFEAIQKRFRTQANIDVSLDAMHIPYKEDGESKGYIIMELANNEEATQAIRAMNGYAFDKRHRFVLNRLTDVERLANMDEAYKDPEEEPFHQRGHLRSWLMDQAGRDQVVMCARDDVLVSWHSRTAQPDEAHKRTRWTESYVQWSPLGTYLATFHMQGIALWGGPTWERIMRYPHPGVRLVDFSPNEKYMVTWSPEPIQVSDNAPQGPQFFAPEDEGNRVAVWDVRTGHLLRTFPILQEDTTGPTGPAIKGFSWPFLKWSGDSKYCAKVTPGKGISVYQLPSMGLLDQKSIKIEGVVDFEWCPLGDKDKDALEIWNDGKNKDLPKGFKKPRDNMLVYWQPEVQNQPARVTVISVPKREILRSKNLFNVADCKLHWHPQGDFLCVKVDRQTKTKKTVFCNFELFRMREKDFPVEVVELKDPVVAFAWEPQGTHFAVISSNDPNLGVVAPSITLKTQLHFYHLHPRGDFRLLKTLDNKTCNALFWSPRGRHLLTATLGSSSKFDLEWYDVDFNNDARQNSSGEVLEEVKLIGSGEHYSITDVEWDPSGRFVTTSSSLWRHSMEQGYAIWDFRGNELQKNIIEQFKQILWRPRPRSLLSKDEMKRVRRNLKEFSKVFDQEDQEAESSQALAHREEYKRMLEEWKSWRAYNREALQKAQEEGKEPTAISSASQLEKESTEEIQEWVEEVLEEKEEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q991</accession>
    <name>A8Q991_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729401.1">
        <property type="nucleotide sequence ID" value="XM_001729349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q991"/>
    <dbReference type="STRING" id="425265.A8Q991"/>
    <dbReference type="GeneID" id="5853708"/>
    <dbReference type="KEGG" id="mgl:MGL_3436"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3436"/>
    <dbReference type="InParanoid" id="A8Q991"/>
    <dbReference type="OMA" id="WKALMEP"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="625"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1066" mass="117135" checksum="759D3B4F5B19A975" modified="2008-01-15" version="1">MSQFKPFGDIPRNTYRSASRGGNPSSSVSNINTPPQSPPIGMGPNTPNALQQQINFLLQDSPPSFDTSSDAASTNTMDPPKPFPPRSLKPLPPPLLDIRTASSPTVGPEKSPSPTERRRGPKSPLRASMSASGRNTPVSLAVKVPSLHELEVTPPTANGSFHAESVRTSTSTARSDSEDGGSWDVCDSAPSTPLRDTFRPQLTTSLAKQLAQTGKGVLGVVHSEDKAHDQVSTSTTHLSMKNCPLSDYNILSIPTMLVVLDISGSQLEMLPFSLSSCTSLEELNISGNPFGRSELAAPLASLRSLEHLRVLLADDCELPSIPQELIVMSQLQILGVRRNRLTCLPSWLYVLEYLDCLLLEGNIYFKPAWKTILHPLLHMDQAESYSPPFVTSNPIMSASSPTVASPSETRKLSGLLSKFKHPNRSGSPLDRTPHRHYLRMNETQGGVSNDKLSTPPSRIPSAVRSSSSSSSQSSLVVPQQTPTKMSIVPVPVTNQPRVNPPPDLKPIECFLPVYDKNSNPEDVLDWFARIGTCHVRNLRAYLRDMDELLPDRQRELATVAFSSTGSSGLGSPTMSFSAFSSTGASDSTPVGTPGDVSMRNGILDEAGEAVAAVAAPSNVKENAIKRYRVLREIVETERTYVAGLTELMEIYLKRARQPLDGVSDDRVLSVEKERLIFGHIEVIIQFHIGAFLPALEEKTRMLLVIPELEEERHALLSAKVAADVANVFSEYAAYFKMYMNYVNQYETALRVIAQWYEPISPRVRSAIKNSSSSLASFGQRFLNLDTALSSDDKASGDSSPMSYSEHKKMQQFLKRCRDDPRHSQINLEGYLLLPIQRIPRYRLLLEQLIKCTSHGVLPDTDQEALARALAHISLVASWVNEGKRQSEQGKRLLQWQTKLRGTFSAPLVQPHRRLICDGPLRLRRVSKRSIQAPSGCIAGFDDEVLEQMTLDLPVTMLLCNDLAVVLSNLTSEEASPHSAKQHATATASSPSGLASSDFGMVDLLAVLRPQVHSFPPSMNKNVTIPPASIVGQLYLRIVDAKYIYYFVTPSYKEAFRWQSLINAQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q999</accession>
    <name>A8Q999_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729406.1">
        <property type="nucleotide sequence ID" value="XM_001729354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q999"/>
    <dbReference type="GeneID" id="5853713"/>
    <dbReference type="KEGG" id="mgl:MGL_3441"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3441"/>
    <dbReference type="InParanoid" id="A8Q999"/>
    <dbReference type="OMA" id="HWYTIYL"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="180" mass="20427" checksum="302F109AFACDD884" modified="2008-01-15" version="1">MPSALVNALSALFFDVSSPNYSLLALPAMYMITILPHWYSIALSMFYNGEWANENPRAFVTRLAARPILGDKKSQHTPLERKILRCQACQQNGFENMPIFGLALLCGILADLPGYLMNMMATLFILSRVLYTLAYVLSDSRSMSYIRTICFVGQVALYMRFFMQAAWSVAGRDQTHRWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9P8</accession>
    <name>A8Q9P8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729496.1">
        <property type="nucleotide sequence ID" value="XM_001729444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9P8"/>
    <dbReference type="FunCoup" id="A8Q9P8">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9P8"/>
    <dbReference type="GeneID" id="5853803"/>
    <dbReference type="KEGG" id="mgl:MGL_3531"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3531"/>
    <dbReference type="InParanoid" id="A8Q9P8"/>
    <dbReference type="OMA" id="AEDNLPW"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="55"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="349" mass="38774" checksum="507DA32A05B80526" modified="2008-01-15" version="1">MDVKGKAKSLDDASDASSSHDLLPWVEKYRPSSLDQIMSHQHITATLEKFITANQLPHLLFYGPPGTGKTSTIMALAARLYGASFRNNVLELNASDDRGIDVVRGQIKAFASTRNVFSTQKDTFKLVILDEADAMTQAAQAALRRVMEQYTRNVRFCIICNYVNKIIPAIQSRCTRFRFSPLDRVQVERQIDSVIAAEHCQIDAKAKHAILQLCQGDMRRALNILQACHAANDMIDEDSVYLCTGHPHPQDIETAFQAMLEQEFTTAFQTIQTLRVEKGLALTDLLTGMHALVLSLELPPHARVFLLDHMAQIEYRLSTNASERVQLSALLASVKAAVELAHTPPSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9Q3</accession>
    <name>A8Q9Q3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_3535</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729500.1">
        <property type="nucleotide sequence ID" value="XM_001729448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9Q3"/>
    <dbReference type="FunCoup" id="A8Q9Q3">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9Q3"/>
    <dbReference type="GeneID" id="5853807"/>
    <dbReference type="KEGG" id="mgl:MGL_3535"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3535"/>
    <dbReference type="InParanoid" id="A8Q9Q3"/>
    <dbReference type="OMA" id="VDVMFHR"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="262"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="447"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="193"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="904"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="904"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP42286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="953" mass="107151" checksum="95296CA363B5ABEB" modified="2008-01-15" version="1">MGGPFQRYGNESAQRSGKQEYDDLSDNEGWDDDDDLEVDREWYLQDDDGGVAGDADHNPFAQYEDMHGQVSNVLARRQQRMTARQAQYNVDLDAWEKSRLQSGGVGGRQAVRDDLDDHDENRIHLLVHNLRPPFLDGKTVYTKQIAPVNPVRDPTSDLAVFAMKGSRLVKEHREQAERAKAAGRVASLKGTQLGNIMGVKDDDDEDVKDKSKIDPSQDDGKGDSKFASHLKRGRGASAFSRNKSLREQRQYLPAFACREELMRVIGENQVVVVIGETGSGKTTQLCQFLHEDGYTEYGIVGCTQPRRVAAMSVAKRVSEEMECPLGGTVGYSIRFEDCTSKDTKIKYMTDGVMLRESLTEHDLDRYSAIILDEAHERSLSTDVLMGLLKKVLTRRRDLKLIVTSATMNAEGFSKFFGSVPIFTIPGRTFPVDVLFSKTPCEDYVESTVKQILTIHLSQGKGDILAFMTGQEDIEVTCEVALERLSQLEGAQPLLMLPIYSQMPADLQARIFEPSENGERKCVVATNIAETSLTVDGIMYVVDSGFSKLKLYNPKVGMDSLQIMPISQANASQRSGRAGRTGSGIAYRLYTEVAFHNEMFPSTIPEIQRTNLANTVLLLKSLGVKNLLEFDFMDPPPQDNIITSMYQLWVLGALDNVGNLTPLGHKMSEFPMEPSLAKILIMSTEYKCSEEMLTIVSMLSVPTVFYRPKERQEESDTARERFYVAESDHLTLLHVYSQWRNNGFRDGWCNRHFLHAKLLRKAREVRAQLEDILRAQKLPIVSCGTDWDVIRKCITSGYFHQAARVKGVGEYVNCRTGVPMHLHPTSALYGLGYTPDYVVYHELTLTSKEYMGIVTAVDPYWLAELGAVFYSIRETNALAASSRRGRDTQLSRLVEIETEFERDRQRAADEEANELKRFKRNPGPSIRGSTNRDGIAMPGIGPPRRGRRLPFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA55</accession>
    <name>A8QA55_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3614</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729147.1">
        <property type="nucleotide sequence ID" value="XM_001729095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA55"/>
    <dbReference type="FunCoup" id="A8QA55">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA55"/>
    <dbReference type="GeneID" id="5853453"/>
    <dbReference type="KEGG" id="mgl:MGL_3614"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3614"/>
    <dbReference type="InParanoid" id="A8QA55"/>
    <dbReference type="OMA" id="HVLNLKI"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="11">
        <location>
            <begin position="174"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="411" mass="48359" checksum="C4F3EC7D5EDDD553" modified="2008-01-15" version="1">MSAAAVNQAAETRADLEKKRNGVKHANSLLKDIVTMRWLVYPASAAKIALIFVLGYMMFEYALPFSVNPFQPFLTLSYRIPESEVVLRLAQNPIYGPTPSYSLDNPVTTALRDFFRSTHAKLFPNEPKLLRYGKGWLDVCFMGFYIIVFSFLRQVITGHIFKPLAARWNLKTENKCVRFAEQGYALTYWGVMSIFGLYVMAFQDSWWYNLDHLWYQYPHWQMRPELKLYYLLQASYWLQQAFVMLLGLERPRKDYYELVAHHLVTLWLIGWSYFINLSMIGTTVFVCMDIPDTWLALSKMLNYLNKNMAAAAVYSVFMVVWSYFRIFLSALTLYSVYADYTKIPAYARTFHPSQGHWLVWWMQCHVFAPLFLLLLLNLFWYALMWRILYRAINGVYGDTREEGEDDHGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA72</accession>
    <name>A8QA72_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729164.1">
        <property type="nucleotide sequence ID" value="XM_001729112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA72"/>
    <dbReference type="STRING" id="425265.A8QA72"/>
    <dbReference type="GeneID" id="5853470"/>
    <dbReference type="KEGG" id="mgl:MGL_3631"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3631"/>
    <dbReference type="InParanoid" id="A8QA72"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="157" mass="17667" checksum="B3737228074200D2" modified="2008-01-15" version="1">MRQLQFHGPLNKTGISAAELHERLREFQKELSETAQGDLDTSQLDAYCQELIKPTFLRHKHKGIQAIVACILADMLRLYAPNAPFSSLEIKHLFRFLLAQLVSPSHGLANPDDPLYKDSVYVLESLSTVKSVVLVCDVPSANELITEFFEKLWSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA94</accession>
    <name>A8QA94_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729186.1">
        <property type="nucleotide sequence ID" value="XM_001729134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA94"/>
    <dbReference type="FunCoup" id="A8QA94">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA94"/>
    <dbReference type="GeneID" id="5853492"/>
    <dbReference type="KEGG" id="mgl:MGL_3653"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3653"/>
    <dbReference type="InParanoid" id="A8QA94"/>
    <dbReference type="OMA" id="VMDSKHH"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="337"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="582" mass="65127" checksum="4616B116BEE87037" modified="2008-01-15" version="1">MAGSTGNRWTLQYPDTLRESAVGANVWREAPPLTTVGLRIQSQKQHMPHMQQQQQQQQQQQAHVRASAQTQAQRIRARNHYDILVGEGFRGTKRDKPTDRSLPPFIKRQVKESAIYNDLQRMERNLDWIMACKRAELMDSMGKPPKVKRTLRIFLSNTCANQPFQVAEKEQRRDATEMTADADDGDGGDDDDSGAAAPRPKSAAKTDHTDVPSWTLRIEGRLLDPSFRSRAGAALSAHATAARIGAHKFSNLIKSCVVEFSRDPNLYPDESLGASNIVEWHRPSPSVAPQPSIGGTGANTATENPLIHSAEPALDGFEIKRTGTEPVKAKIVLYPLYVPERFSLSPPLAQLLDIQEETRAGVLGALWGYIKQHQLLDENDHRVVRLDAPLQALFRTPTINFHHVPEVLHRFLHPPQPIVLEYYVRTDKAEHRNPMAFDIELDMDDWALRMRQHNVLTRFDANSSLSNEIAALDDQIAQTALTIRNRAAARQFFTAFAQDPQGHLNAWIASQARDLDALLGASQTGRGADGETGSSVHFSSEEMRRAETFHGAWVNEAVIVSESQRLAERLQELQSDTVRTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAR1</accession>
    <name>A8QAR1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_3814</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729026.1">
        <property type="nucleotide sequence ID" value="XM_001728974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAR1"/>
    <dbReference type="STRING" id="425265.A8QAR1"/>
    <dbReference type="GeneID" id="5853333"/>
    <dbReference type="KEGG" id="mgl:MGL_3814"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3814"/>
    <dbReference type="InParanoid" id="A8QAR1"/>
    <dbReference type="OMA" id="VHDYQFF"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="165"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="488"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="15">
        <location>
            <begin position="844"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1024"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP41812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1053" mass="121143" checksum="E92E066391F63099" modified="2008-01-15" version="1">MVADDGDNSHHVTKAESSRTMDASEQRAQRRVAQNESLDASRTEMNRQKSIDSLKRFSYLLGQTELFQHFIDMKKDRDPEFARLLDESTQKRGKNKGGKNQGKSKGDAASDQRHHRKTEKEEDEELMQDENDDDEDNVFMFRESPGYVEGGTMKDYQIQGLNWLISLYHNGINGILADEMGLGKTLQTISFLGYLKHYRNTPGLHLVVVPKSTLDNWVREFHKWVPGFRIVTLQGSKEERHALIHERILPQAFDVLVTTYEMCLREKPTLQKLSWEYIVIDEAHRIKNVDSALSQIVRAFTSRSRLLITGTPLQNNLMELWSLLNFLLPDVFSSADDFEAWFQRKGDTGAETSKADDADAIEAKPKDDHEDDADRHGSIVQQLHKVLRPFLLRRVKADVEQSLLPKKEINVFVGLSDMQRKWYKSLLEKDIEAVNGALSKKEGKTRLLNIVMQLRKCCNHPYLFDGAEPGPPYTTDEHLVYNSGKMDILDKLLRKMKERGSRVLIFCQMSRMLDILEDYCLFREYTYCRIDGSSVHEDRIAAIDEYNRPDSDKFLFLLTTRAGGLGINLTSADVVVLFDSDWNPQADLQAMDRAHRIGQKKQVFVYRFVTDHSIEERILERAAQKLRLDQLVIQQGRSSSAQQKAGQMKEDLVDMIQHGAERIINSKESMDVKDDIDAIIAQGESRTAELQAKYQQFTSLDELTNLKSESAYEWEGEQYKGRKPGVGTGIWIEPAKRERKQNYSIDSYYRDAMRTTSKPAVPKAPRAPKQVPTPEWQFYPARFIELQERETAAYQRSLHYQVPKSESSDPAAAEEQRAKEQARIDAAEPLTEAEQAEKDELAPQGMSAWNRRDFQQFVKGCEKHGRTAYGAIAEEIGLGDKTEDDVRAYSEVFWARVHELSDGERIVQRIEEGEAKRRKQQEHESLLRRKVDAYAAPLEQLKISYNQAKGKAYSEDEDRFLLVRLADYGLHADDVYERIRADVLAYPEFRFNWFIKSRTPQELARRCHTLLLLVIKEEEDREAAAANASKSRKKRNAPEARGSPRPSSRARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAV6</accession>
    <name>A8QAV6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729050.1">
        <property type="nucleotide sequence ID" value="XM_001728998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAV6"/>
    <dbReference type="STRING" id="425265.A8QAV6"/>
    <dbReference type="GeneID" id="5853357"/>
    <dbReference type="KEGG" id="mgl:MGL_3838"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3838"/>
    <dbReference type="InParanoid" id="A8QAV6"/>
    <dbReference type="OMA" id="PFVHTYE"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF95">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="187"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="453"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="808" mass="87833" checksum="B0903686C4ECBE7A" modified="2008-01-15" version="1">MNRTPDIVNRANAIEKELKARAESLSSAQESYELDLATQGLEDEPAPDEGMPPPPYSASSSPRDPPPYRRAPRLPTPSAPSSAVPASASTSPAHVRLSAASSPPRPRTGGLPLQPDAPALARTPSLRPTAAPSSSSMLRQDSPPKPTIPIGQCLSVEQLWTYMYPGFDRTTDDSGQEFLVKRVGLSILLVDVRPRIEHETGFLRGADTVCIDPKLLLAPPVSAAELQASLPPNEAAFFARRAEYDMLVLYDQKTRSFGSQGNATPEQERLETVVQAIESDVLYSPCLLRGGFDSWFRQVGECGIISLNGMRPSSSSSSSFATGANAPLLSHPRRSAPATHARTSRLTPPSMPPRTYQQHQPMAPTLSSSSSSSLSSSPSSSIPSLSPSSSQLNARFEYPKVGAFSSSLSSVAPMPPAPAMPAPMPASLIAGPVRDVMAAPSFPKPRDIRIGLTGLRNFGQTCYMNATIQCLSASVLLAQYLLDGTYKRAINTQNPLGTRGALANAFASLLRALWSEQSVSVAPTAFREAIGQFAPAFRGNEQQDSQEFLMFLLDGLHEDLNLVVQRPPALELGEAQQAELSRLPQQLASVAEWSLYRRRNDSIVVDTFQGQLRNQLTCLTCGHTSITYNAFMSLSLPVPTGRGVSRASLYQCMDAFVREEVLEKGNAWHCPKCKKPRRSTKRLSLARLPPVLIIHLKRFTFRGPASNKIETPVVFATDALDLSNFMPPPLPPGTSVRGIPISESQRPPYLYDLFAVTHHFGTLHSGHYTASVRTQGIWYYCDDSRITPSDAQIQTSSPYVLFFSRRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAZ4</accession>
    <name>A8QAZ4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3858</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729070.1">
        <property type="nucleotide sequence ID" value="XM_001729018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAZ4"/>
    <dbReference type="FunCoup" id="A8QAZ4">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAZ4"/>
    <dbReference type="GeneID" id="5853377"/>
    <dbReference type="KEGG" id="mgl:MGL_3858"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3858"/>
    <dbReference type="InParanoid" id="A8QAZ4"/>
    <dbReference type="OMA" id="IMETHHA"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="113"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="218" mass="24152" checksum="8C633AD78672702C" modified="2008-01-15" version="1">MFGFASRRAVSMATRMGVRSKHTLPELPYSYGALEPAISGQIMEVHHAKHHQTYVNALNTFETQLSETLAKGDIKGAIALQRMVTFNGGGHINHSLFWKNLAPSSQGGGQLDSGELRSAIERDFGGVDEMKQKFNAALAGIQGSGWGWLGYNAQNGRLDIVTTANQDPLTTHTPLIGIDAWEHAFYLQYKNDKATYFKNIWNVINFEEAEKRLLAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBU8</accession>
    <name>A8QBU8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HRDC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3943</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728949.1">
        <property type="nucleotide sequence ID" value="XM_001728897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBU8"/>
    <dbReference type="FunCoup" id="A8QBU8">
        <property type="interactions" value="652"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBU8"/>
    <dbReference type="GeneID" id="5853255"/>
    <dbReference type="KEGG" id="mgl:MGL_3943"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3943"/>
    <dbReference type="InParanoid" id="A8QBU8"/>
    <dbReference type="OMA" id="RWGDWIV"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="481"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="106"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="695"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="699"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="733"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="849" mass="95224" checksum="81766051BB31039E" modified="2008-01-15" version="1">MEERLSKVSEALVPATRTASLLPSSTDLDFYCSIDPDVKRALERISTDLQDVVNFMTTWMGEEAGNRTLDHLSAPTSFAGSVGDTVDRLLERADIYLDEYTGVRKISPSREKKSSQETSSTGADESDMMIPSTGKLPPHLQRADIPKPQDKFSRQPDNRANTPWERTFQFGKPNARVPIGWRDPSWNVSSDAIIEGQYGTEGDPRLGPYYVEIQQTPVPESAFHVGNAEAPVPLRIENPGSSQPCDFVWVDSAEKVRQLQKHLEEERVTEIAVDLEHHNQRSYQGIVCLMQISTRWGDWIVDTLVDEVRESAELLNTAFTHPDKVLVLHGADHDILWLQRDLGLYVTNLFDTFQAARALQFGALSLAFLLLRYTNFEADKRFQTADWRIRPLPREMLFYARSDTHALLYVYDCLRNELLQRGGPLAVKEVFDRSKPTASKVYAKEPWDERGNSRGGWKSLWIRMGGDLARASQDAPPDAPLGREERIVRRLHHWRDQVARKEDESPAFVMPPRVLIQLALRPPLNLSEAKARTPPSLKFVRSRLDELVKTVKDEWHAYLSDVRPESLGDESTVDKLGEPLSSSKTEAEEDLGEKWMPTSTIPQEASSMAVAQEVPMHPDVWARQPQGKSSPDAQLFRGVKVLDEPEKPKKSKSLFEMPSARAPAQVSRTLQNIRTDLVQRLGTLVGAAWGRPAAELQPEDNHDQPKEDTHPIIDNPEEERASKVATTAVKRAFSQDRQDSDKEARAAEEAARQTEEHDVGTDPVVQVRKHSGPTRKRQRAKSTPNSGIPVAFDYGSASSMLEAPRPHAQASLLPTSTSGARKVAEPKGARQKSNVRHGNKSGTFATRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC36</accession>
    <name>A8QC36_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728977.1">
        <property type="nucleotide sequence ID" value="XM_001728925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC36"/>
    <dbReference type="FunCoup" id="A8QC36">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QC36"/>
    <dbReference type="GeneID" id="5853283"/>
    <dbReference type="KEGG" id="mgl:MGL_3971"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3971"/>
    <dbReference type="InParanoid" id="A8QC36"/>
    <dbReference type="OMA" id="NASLKEW"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="57"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="382" mass="42712" checksum="8B618F9C9EA35EB7" modified="2008-01-15" version="1">MAPVAALAPAVPPALTTCKSISASPSIASLVRNTKSSIASRQPLQVSGLLDSLYEFDELTPGLGRLYPTIQLRDLIYHEKADELIRDLAIIISRRGVVFFKNQELSADEQKFVTDRLGHLTGKPATSGLHIHPVYNAERVGKDQVVDEKGTQNKDNEISVISSNLHRSLDVEPRSGADEWHSDIAFEPVPADYTSLKVHTLPQTGGDTMWASGYEVYDLLSQPFRNMFEKLKGFYYPPEFINSAARHGYALYPGPRGAAENVDTHLTAEHPLIRTNPVTGWKSVFGIGHHFNRILGVSLDESDMLKRYIRDLVTQNHSTQLRYRWGKNDLAIWDNRSTYHAATPDYFDLGPRSGIRAVSCGERPFFDPASRSRREELKGKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCM7</accession>
    <name>A8QCM7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728859.1">
        <property type="nucleotide sequence ID" value="XM_001728807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCM7"/>
    <dbReference type="STRING" id="425265.A8QCM7"/>
    <dbReference type="GeneID" id="5853165"/>
    <dbReference type="KEGG" id="mgl:MGL_4026"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4026"/>
    <dbReference type="InParanoid" id="A8QCM7"/>
    <dbReference type="OMA" id="WIAVKEN"/>
    <dbReference type="OrthoDB" id="3366638at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="654" mass="72153" checksum="9E44826D5959430B" modified="2008-01-15" version="1">MTGRPGCVRVRVSTKEPLPTAQFWIAVKENYDLEMLRTHVARTLESHYDTVVDPATLNVAIHDFDLCDDVGQILQEGDLITVSNLKRRKTLVQEHETSGPTKPVVDPETERAIMAEANRISLLMRSQHHEAPLMKKTLGTKRKLSTPMTSTFTHRTQRPQLVHDILDDVEQADLNDELNEIDDVDENDYVDENDYDDVVGDSPSVGNELFRNEENGQEQGQVCSKDSATAENPIASKSESRSDSGSDSSDSNSDSDASSESDSSDSSSDSDANSESDSSDSSSDSDANSESDSSDSSSDSDSSSDSDSNSDAYDGNNIKINETSSSKSPLPASSSSSPPSSEPVSKPEGGYDNDNFQHSQSPAFTTHVRALSDSQSWVPPGQGKDRTRHKNQKRRERRRAAREAQNSKSSVDALVSEYPLASVDPMVHGKLPPGGGSLDIEPSSPAPAPKSSSPVEVVSSLENIAQRMLSRTTVGHRKRRKRSQANAMAPSSTPVFAKASDLIQPTHLNRPTERIPYPSKLPSDEFPSNMTISSIDCESWYDQQWYDEEQESEDVDESTRAYINMQRQVHASLAEEKRLEEEQVRFYQDDTHIEEQEPLRESLPRAFGRARNVEALAPELDYGTPSPQSLPVHSNASHPFFRRIESIRASIYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCP5</accession>
    <name>A8QCP5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728865.1">
        <property type="nucleotide sequence ID" value="XM_001728813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCP5"/>
    <dbReference type="FunCoup" id="A8QCP5">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCP5"/>
    <dbReference type="GeneID" id="5853171"/>
    <dbReference type="KEGG" id="mgl:MGL_4032"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4032"/>
    <dbReference type="InParanoid" id="A8QCP5"/>
    <dbReference type="OMA" id="QIHEEMF"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="186"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="333" mass="37326" checksum="BC3511C874C0F442" modified="2008-01-15" version="1">MGVVRESKGKLGSKKLSNAHDTVSKKHASAVKKGPAKHGKPLKAKDEVTQNPTKKKIKSVRIHEVPNVVQFPSNKAPASLKTIPKKQKGDAVEKVSEIEDGDDEDANNDAELLSGFPDSISDEEDEEDDAMTKQAGLTLEEVANLPSSRGNASVTERLEKAKKKKNHKEHKPSEAGDGDKDGTKTGVVYVGRLPHGFFEDQLRAYFSQFGDINRLRLSRNKKTGRSKHYGFLEFDSPDVAEIVVDTMNNYLLDGHMLQLSMIPPEKVDPNLWVGANRKFRTAPVDRMERARRSRSRTLEERAKVNQRLLQRQKKRRAALERAGIEYDFSGYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCS9</accession>
    <name>A8QCS9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728876.1">
        <property type="nucleotide sequence ID" value="XM_001728824.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCS9"/>
    <dbReference type="GeneID" id="5853182"/>
    <dbReference type="KEGG" id="mgl:MGL_4043"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4043"/>
    <dbReference type="InParanoid" id="A8QCS9"/>
    <dbReference type="OMA" id="FNRMAFS"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1502"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="958"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="960"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="975"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1760" mass="197933" checksum="1B25C394FCCECA21" modified="2008-01-15" version="1">MEPDPSPKASTSSKSGIGIPFLLSFRSRNTASEAGRSENESASSQSDMLSDIRGAIEQLLQPKLPVAEQRMRMQFLIECLMRDPAELEPLLDPPIATPLVSSLIVLCSRLLRETFAYELRVLSCELLTSTLRYADVSTQSVSSEVWKESSSATGWQAVMPSRALSMLDRAMLYRLIVNLHRREDWILPKIFEEPSQAFHTLSRQLAALQVLTRDGRDILAFKGIFNVMTKWLRYSWGALLMFRRHEMSGMYTLSEHCTYTLFDMFTSICKFNASRLEKEHMKQYLICLCELVLNPRIPTLARSKHSRHPSSSSSPSEATTTVAAASLAATSNSSTAIATTTATAMSSSSGYKYYGMEDVSTYFDTPSLYPIDGQPENERQTEKSGVYIGIQDSEFPFIKHEDITGFAKSLDSIICYTFVPPECLSECVHSLCRLIGLPIAQTEEQMLVSRLSLHSVDIQSDFRLVLNNLVCSHIVHLMFRHLYEILCTRRNGNRSVRVGALLFIHATMIWNVAQRMEQGGHVKTSPLISQALFESMIRGAISQSDDVLDLICLFLIEDYLPERQLCADASLFENVPVRVRQAPQPLCTLYDDAISTSWGILADLVPLMNRHLSRRRRGIKMMNMSSFVLHTLVGLLCSRLEQPLISLPIISNSFWGLAFLLPDHVLLSMIKANENQHIYLPSTPDWLDNLIQLCDTFYPKSGLDASGMHALMSRTSRLYAVKLVVDVYGFVQDLPLLRDPMIQHVVVPLASRAAQKETDIEIGVPIRRMVRHAMVTAVCTPTINGCKPFYDLLRCLVDNVFKANLTNAENLEKPQAMAQHSRQRSVGPHNVDDIRDARLRTTRATRSILDLITLFMQMAFGISDASTMAPELDTSTSEVQDRLRECSLAVFRELLRMIQANAPFSSVSEDSNSSSTRVPVSLRLMILRWILRLRADTQHRIYFQNHEEDFTKSLVQTLSRNEDPRDQQDRGRSGPHSSTLSHATSQPSVDETQESNAAPPEVPSSEFPEASWSSCIWQVSQIGVHGSRIAEHAEDNKSDTVPMLFPTSEYLEAMLNILQSESDWEVLSYIISHLPSQLNNKHLFCGVKATTKICELRDWLCPLLLENKPLPNLVLPGDLRRTDLTAVLYATLKVLMAYHCLFTRAQQDELVEAFAAGLSHSQTVAQPCVRALVVAGYELSKSFTRQLTNILVKLSTIMSSIQMSVHILELLAEVSSVQALYANFTEADYRRVFGIALQYIQFHESKAASDTREDLRSSPAKFALSQYVLLLAYNNISQWFMTLKLSERPKHASYITQGLMLANEGRESPSDQTIVCLDFLARFTYSNALPKPSRSILHRLLAQKNDVAPPSRGSTWLLGKGLISIRPLARSGTFEATVRRPSGTVAFVCRLENMVSDGRTAEERTADILAAALERWKSEGSINKPVIEAPNESESAEAAICMPDTPSDTALSKRTEDDRLQTSRMTDVEPIFMALQFSGYPDQSNETPPILLPDDPMTERLLRAMDLTPVYDFHKIGLVYVGYKQTTENEILSNTHGSMAYMLFLSRLGDLVPLLGQEDVYTGGLDRQSNEHGKYAYVWRDYSKQIVFHTSTLMPNHPEDPNRSHKKALIGNDWVHIVFNDSGLPYEFGTIPSQFNFVNIVISPHSTVREGVDYSVTDETYFHVTLQLRPGLPDFSPAGEGCLVSFATLPRFVRNLAMQSDIMSQIYLDTAESMVPFSNNRVTRLHLVERFRQQFMARNPETFASASEKSGYDFTELLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD24</accession>
    <name>A8QD24_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728757.1">
        <property type="nucleotide sequence ID" value="XM_001728705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD24"/>
    <dbReference type="STRING" id="425265.A8QD24"/>
    <dbReference type="GeneID" id="5853052"/>
    <dbReference type="KEGG" id="mgl:MGL_4092"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4092"/>
    <dbReference type="InParanoid" id="A8QD24"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="61"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="438" mass="49092" checksum="AD21247177D4835E" modified="2008-01-15" version="1">MSQPYENPVDRRKWTPEEDGMLKMAMNNLKDCRETRWTEIAASVPGRSAKACRKRWVNGLNDRLKKGSWMKEEDDRLREAVAIMSNDWARIAEYVGQRSGDQCSKRWREVIDPAINKTSWTNEEDELLVSLFHKHGSCWQVISTHFNNRRALQCRNRCCKLLGLHAHPRKKACNYEKLSPLSSEFVCSPIVSPTLQADSTGVAPLQNGSHDATVPGDMLNLNNLFSTPAESTTPNKHSLGVSEEANLMNYASQLEPSSNNTTTSYPSNPCNDYNDVQTMQFIEAWSRVQGYASAERKGPPAALNLDLETTLFSMSTPTEPNYSPFLDSAVSLPSSTLTTPCTQGLTDAFVLNNYDTINGMQQPLLATSNSCDESAKEFFLPNHSYHFNNECMADTVKLPSSESTASYEGYLQTAIQNPVLVSEPIQLDPFNIQPYRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD52</accession>
    <name>A8QD52_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728785.1">
        <property type="nucleotide sequence ID" value="XM_001728733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD52"/>
    <dbReference type="GeneID" id="5853034"/>
    <dbReference type="KEGG" id="mgl:MGL_4120"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4120"/>
    <dbReference type="InParanoid" id="A8QD52"/>
    <dbReference type="OMA" id="GTHMSAR"/>
    <dbReference type="OrthoDB" id="2538032at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="548" mass="57596" checksum="508C0C546844F13A" modified="2008-01-15" version="1">MTSDMSRSLSADESSSVRGTALPHPHGIYRSKAPSNISLSPVRLSSTFLPSPLRDHHATTTPTNGAASPRLISANELPDDPAQASNVVHLFAPPLAPAWSPVSMSRSQSSRTDDTSTYFPSAGGTTASHGHSYGHGAGTGTGAHTASTQRYYRPPMSPSARSGAEHALSPGAAQQRISSPRSPTGPSYVGMTRTSSRQRSPEHNIFERDIELCGSPHLMTPKEAIDVAVPPVLDDAADAIVGDSTLEIVSPCETSSPYASPDMRPHLRRTGTGGEMLVRGASHDGTHMSARQRTYGHRRLHSEQSMLLPSIPNMPSSPAAGKRRSHMQPPSQTHSQQQPPTPNASTYHPSLSIDGAVIPEGQAATFMHSLDGLADAVVHRSPSTTSAQAAVPGSMATPASPVPAVASPSGSTNGSQLGTSNSYFSLSEDPRNSKFRYSVIGINATPSGAPGDSPTFGRTGTANNYFASSVSSPRSSRTMQPSLSWSNSENCSSHLQVPGALNAASPNLRPASVSNAQGDRKRLSWMSYADIVNDVNEKVHDLDVTGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD83</accession>
    <name>A8QD83_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_4151</name>
        <name evidence="10" type="ORF">MGL_4157</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
            <strain evidence="9">CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728672.1">
        <property type="nucleotide sequence ID" value="XM_001728620.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728678.1">
        <property type="nucleotide sequence ID" value="XM_001728626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD83"/>
    <dbReference type="STRING" id="425265.A8QD83"/>
    <dbReference type="GeneID" id="5852971"/>
    <dbReference type="GeneID" id="5852976"/>
    <dbReference type="KEGG" id="mgl:MGL_4151"/>
    <dbReference type="KEGG" id="mgl:MGL_4157"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4151"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4157"/>
    <dbReference type="InParanoid" id="A8QD83"/>
    <dbReference type="OMA" id="YANIELM"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16996" checksum="91E24C0B37E33583" modified="2008-01-15" version="1">MLLNPAIQEKAHAEIDTVVGPNRLPGYEDEVHLPLVRAIIKETLRWRPPTVMGVPHAVTVDDEYYGYKIPKGSTVIGNSTCSPKILDVLIWPVFAMSHDPKRYPNPELFDPEARFYKSHPGSAAEYATKRNSLERDHFAYGHGRRICAGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QE41</accession>
    <name>A8QE41_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_4254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000025">
        <property type="protein sequence ID" value="EDP41399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728613.1">
        <property type="nucleotide sequence ID" value="XM_001728561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QE41"/>
    <dbReference type="FunCoup" id="A8QE41">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="GeneID" id="5852917"/>
    <dbReference type="KEGG" id="mgl:MGL_4254"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4254"/>
    <dbReference type="InParanoid" id="A8QE41"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="56946" checksum="60130242F680E690" modified="2008-01-15" version="1">MEKDSEKRTDIESLESSCRQSISFHQRLETKLYTFFLPLLQFEAWLNSKLGIEAEAIERKRGEDRKPVKWYDELGMAFLWASGNLNLPCCATGMLGAEFGLSLRQSLVIIFFGNLIGSFVTSYCATFGAPTGLRQMSVSRYSFGWFPSKLIALVNTVQQIGWSSVGAITAGLALTAVADGHISIVVGIIIVAVAALVIGIFGLRLILLVEKYSWCVFFIVFLIILGETGKYADNHSPASVKGTTPLAGSVLTFLAVIYGYSASWSPIASDYYVQYPANVSRTKVFLLTASGISLSTCVCMWSGAIMASSLNNHPLWKQAYENDGIGYLIRDMLYPTGFAKFLLVLLVLSGICFNLLSTYSVSLTIQQFSPWVAFVPRIVVQVIVFGIVIALGLAGRKELNTYLQNFLSFLGYWSTSYFVILFLEHTFIRKRDFANYDLEGWNDRKRLPHGIAAATVFLVGVVCWVMGMAVTWYVGPLAGLFGENGGDVAIELTFVFTLVAYLPLRLLEINFFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR09</accession>
    <name>A8PR09_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732790.1">
        <property type="nucleotide sequence ID" value="XM_001732738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR09"/>
    <dbReference type="FunCoup" id="A8PR09">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR09"/>
    <dbReference type="GeneID" id="5857096"/>
    <dbReference type="KEGG" id="mgl:MGL_0565"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0565"/>
    <dbReference type="InParanoid" id="A8PR09"/>
    <dbReference type="OMA" id="NWSREST"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="105" mass="12036" checksum="A6A5733B6CE6F2BB" modified="2008-01-15" version="1">MAVVMTNWNATILGPANSVHENRIYSLRLVCGDSYPQVPPEIWFVTKINLPCVDQSNGRVRPDQFMPLLQWRTDYTMESLLAELRRMMALPANRKLAQPPEGTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR16</accession>
    <name>A8PR16_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair protein REV1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_0572</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732797.1">
        <property type="nucleotide sequence ID" value="XM_001732745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR16"/>
    <dbReference type="FunCoup" id="A8PR16">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR16"/>
    <dbReference type="GeneID" id="5857103"/>
    <dbReference type="KEGG" id="mgl:MGL_0572"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0572"/>
    <dbReference type="InParanoid" id="A8PR16"/>
    <dbReference type="OMA" id="IKNGMWM"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="14">
        <location>
            <begin position="143"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="15">
        <location>
            <begin position="370"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="765"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="894"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="792"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="821"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="902"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="941"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP45583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1199" mass="132668" checksum="FF6A7B771F3CE43F" modified="2008-01-15" version="1">MPCSTPPSSFPCSDESVLLEALEQVERQDAFDVYEDPWPASSPQQASLQDQPLAQEERTACETCPALEPAHSSRPTSLLTSRLPHASPPTNAGRRLAGGDTTYLETDAYRAIPFGDFGTYMKNKRLKLQVQEASLLEDEPAGLESDALRGCSIYITGRTDPPYKELRRMIVLHGGQVLTYLDHKRACTHIVASTLPPKKVAEFRAYKVVSPAWVLESCRMRQRANWTQFRLGGTHTTPWTTVFDAKRANEPSSTANDACDTVPADAMTPHTVATATSKNAAGLSRPDEPASCCSLFPTTTNQRAAELLRSEAWRAKNTAASRDFLAGFYANSRLHHLSTWKNSLQDLVASAVSESGTPPRGRSTDLPRTIVHIDFDSFFVSVSLRAKPAWRDKPVAVCHATLTGTDGSSSTSDVASCNYVARRYGVKNGMSLRQARHLCPSILPVPYAFDAYYQVSLQFYAVLLHVADVLQVVSVDEALLDATDLLRALCEAQASERFAWPTSDAILSRLEAQFRLHLARHAGVQPAHALGEALRDVIRLETQCEASVGIGANILQARLATRQAKPCGVYVLDRVEEHMQMLDVRDIWGVGFSLRERLLAWLGTTCIGDICQRTDEAHMIQQFGPKHGRALWQKFHGHDTHVLQATRERQSVGAHVNWGVRLHDDTEVRRFLQDVCAEVMRRASHMHVSAATHVQLQVMQRADEAGESPKFLGHGLCRTFHRSIRRRVYDRSSLYAAAWPLLQKLQIPAVDVRGIALSVSGLERGSTRSSWPWESREKHRPASEAGLSESKSTSDFESRQHQPSPAHEDQALLTTDATSTAERHVDVQRSAEPRSTPCTAHGACASPKTPVALPAPSPSQFQVPSSSQLDSSVMADLPTQMREYIERVLEQRRPPASPIPDATPQQASSSTPTTPSKRRRSLTKQSSSTPVTPTKHRSPTKHSSSTPATPSRQSRLPMYFSPRREKQREVDLASLGIDQDVFDALPPEIQSDVLAERTAYQALRPRHQAPVQGRQTVAAHRRQAAECALMHEARIRVDAGASEHTDPYVHAALRLGLHLDADKEDVVGERVGPYELAPLHPRASLVECPPSAVASVHGFHVHQSLDRMRAQITQWYETCAHDAPRRGDLQRLCAVLKRCVDAYALDKVRGVLLWWRALLRVRRAGDAWLAACRDTVDALQAYVTHVHGGPMDLSDDLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR59</accession>
    <name>A8PR59_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">MGL_0611</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732836.1">
        <property type="nucleotide sequence ID" value="XM_001732784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR59"/>
    <dbReference type="STRING" id="425265.A8PR59"/>
    <dbReference type="GeneID" id="5857142"/>
    <dbReference type="KEGG" id="mgl:MGL_0611"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0611"/>
    <dbReference type="InParanoid" id="A8PR59"/>
    <dbReference type="OMA" id="NCTHNAL"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725333" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="161"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="403"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="22">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EDP45622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="465" mass="50876" checksum="A1D6CAB124286E49" modified="2008-01-15" version="1">MQLTTSLIIASAAFASATASLHDVNSPHLARLQRRQSNQDAASVAKETDPKQECAAAYQNPLEGLKGKKLPEPQKIAEIIDGDDEAKKVWQEIQDSGIIPKDVKQKKDTTSDQQTSNMGTSAQASNYDVQGDPDCWWTANRCTEPKHDKIPKDISSCPEPSTWGLTFDDGPYCSHNEFYDFLKKKKLKATLFYIGTQMYNFPLQAQRGLADGHDICVHTWAHRYMTTLSDEQVFAELFYTARAIKVLMGVTPSCWRPPFGDTDDRVRAIAAGLGLRTILWEEDTHDWQVDQGKTEDDIRNNYQNIIGKADSESPIVLSHELSTKTMKLFEEMEPKISDAYKHIVPITACQNVTKPYAEDITYPDFADFIKGNIEPKGVPDIGDIKANPDADYKVVKLSDMKNGYANPGQGSSGGSKDGSGNGSGGSKDSGKDGKGENGSSSLLDAKIGAISVLVAMVIGTAVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR65</accession>
    <name>A8PR65_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vesicle tethering protein Uso1/P115-like head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732840.1">
        <property type="nucleotide sequence ID" value="XM_001732788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR65"/>
    <dbReference type="FunCoup" id="A8PR65">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR65"/>
    <dbReference type="GeneID" id="5857146"/>
    <dbReference type="KEGG" id="mgl:MGL_0615"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0615"/>
    <dbReference type="InParanoid" id="A8PR65"/>
    <dbReference type="OMA" id="GQETFCN"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="6">
        <location>
            <begin position="408"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="979"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="777"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="914"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="999" mass="110600" checksum="A3071620EB53F3A0" modified="2008-01-15" version="1">MLHGFDLLRQQYKKYSAQSGRAQTPSSTITVLSERLSDPATQHEDRRAAILSLKSLVRDHADKVSEHALVPLLRWIKSRERDEEMLRAAVECCLALCQAHPDDPRTTARASKNMSRLLEEKDALLTLLTLLSPEHGFYTRFGALQLLVVLVENRRLEVQEYVLTAPGGCSSVLQCLEAAPSSSTEIIRNEALLLLPQLLRDNPDIQKITAFEGAFERLLDIMAQEGRIEGGVVVHDALEGLETLLLQNVSNQNYFRETLSIPLLAPLLFYPPPLPAHAPDHAQQEHLTHKQAFLLQEWDEQKLANAQLLLRCVRHLIDGQGEGHRSNQLVMCKTGLAEALVQLAMASLAPLPLKADALHVLASLLRGSRAAQDLISAMVITPVVLKEHSVPVAEGLQPPMELAWQSPHPAMLRLVEMALRVPIQPTDSPRMALRVRCAALQAVEALVEQNMDVRMTMWHAFVAAPTPDQSEPDGTSLLLSSIAHLPNTTLASTSKAPRFDPYQYLFAMMILSYILHGSETSKEFARRVCLNAEGRCVADASVPSSDDDEPATLVHVVVGNLAMALREQSEAVRRERAAQDLNGNPSRDWTKLIVGYLSLLSMWLWQSSASISDLLSESANLQVLIQPAAQTTGVDPLIQGLSAFVLGTAYEFNTLQSSTSDGSTAPTADEQEGLLTRQAMHPILHSRIGADQFSTRIQAVKNDKRFSSCSPETLELVGRPLGEKSASPGPADTMEEDIWFTWPFVEFWKDNYVRIQKSILNEPQATTAADTEASAELLDARQRLMTMEAQLARAQAEAGIVDKLRADLAQANETAELAKKEHAAAQRELHAAHHAHEARENEWNAEREAQQAECAHWREACEATKAQLVSACSDLDALREQLAKGRKEAPSEDAVSLRALEASRQETAAAQAHATHLEQTVKEQEQRLQNLNGRIAELEQAVSSVSYDELKKDYARIESENEDLLVLLDEITQKRVRDKNEMRAAGWTVSDSEDDNLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRF2</accession>
    <name>A8PRF2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 8">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0039</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 8"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732264.1">
        <property type="nucleotide sequence ID" value="XM_001732212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRF2"/>
    <dbReference type="STRING" id="425265.A8PRF2"/>
    <dbReference type="GeneID" id="5856570"/>
    <dbReference type="KEGG" id="mgl:MGL_0039"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0039"/>
    <dbReference type="InParanoid" id="A8PRF2"/>
    <dbReference type="OMA" id="DEVEHIH"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="50"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="602" mass="68018" checksum="8684E83702E1C016" modified="2008-01-15" version="1">MSEQPGPHVETLSWSRYSQKDHPLHFHNLAKRGYHSFQCYQVPFHVKKRYSLVRELGIGSYGCVALAYDSETSRHVAIKKMSRFFGREVLTRRVLREVASLRHLMNCPYVVDVIEFDVTFIEFNEVYLILSACDADLFQIIRSDQDLTEAHIKYFLVQLLRAVHHLHSAHIVHRDLKPGNLLVNADCTLCLCDFGMSRAFDSDNTEFLESLARLGDPASWDHSFAHPEVNIRDVFSVNNIEISSPRESTPGTDLSDHKAFMRFFHPGGSDRLPTKLGLPSVETSQPIKFPGAPLTDYVATRWYRAPEVMLCCRGGYGPSMDMWSVGCIFAELLGRTPVFPGTDYVDQLNRIHKVLGNPPEAVLDRIGSDRAKKHMESMGDRNGVAWADIYPDVPEQALDLLSRMLRWDPQKRITAGEALSHPWLRRYREASYSAQKAQAFTRFDEVEHIHTPLEFKLAMEEESLAIARLQSTGHSEDYCSDCYRSSCFPPSSEDDAHAVENDHQTDVPTSASPETPQNTHVAELSDVFVPSALFAPNSAYDLPSGVSSAPESPLHQNALSKQAESRGARRLSDVECRDQKIQRRGYHESTLFGRACAFIGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRN2</accession>
    <name>A8PRN2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732315.1">
        <property type="nucleotide sequence ID" value="XM_001732263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRN2"/>
    <dbReference type="STRING" id="425265.A8PRN2"/>
    <dbReference type="GeneID" id="5856621"/>
    <dbReference type="KEGG" id="mgl:MGL_0090"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0090"/>
    <dbReference type="InParanoid" id="A8PRN2"/>
    <dbReference type="OMA" id="KMIAKEW"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADS-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="710" mass="77830" checksum="FDD2BA3D7408E54C" modified="2008-01-15" version="1">MPRIPIRIEPYSSPSKQHRHYKSKRDQVLRALGKAAYINGSQFALLLVSARGDVETYASEALQNRLDPWFVKSGIADEARHLAKKSHEETRTTISPSINADDVLGDNLEDIVAPASASSTRVSDDPFLDSWCTLPMDASQARQSNDDWQLRVKREAAAEEIPGTMDQMSETSSPHPKVPRTSTPVHASVFRRVPQPAIMRPNTNGAHVAYTLELKDEEARTAFFELRFSQLQQVMCKMIAKEWVKVIEPKKQTRFPYNKGEAGKPSWWPADVRHKEPDHLMKPERHALLLAILRSPQTRIARLQLATAEVVALIKAGKVAYLMDVYRVAREEEKLRDDGMDKNTPITVSVSSLEGWDAAAGCPSALGMNSSADTSDYESKEVKGKRRLSSRWDDDEHSEPNTSVSWTPTMNDVYSPQSHPLVSTVPPPSRVPFSGGHSGLGIHTADLPSKGRTPGSTPEVSMLSPSLSTETPAQGPTLNMGASVPVPLVQSPVTTSQPLPIQSYGAHGTDLPRSSSISHSVTSVPMRPTHSSPAHFNQQQPEGLNSRPSQSSIPSIHFEQHTNHGNGSLDPHAQRVPWSVHTPVTPYQRSQVMSWSMPETPAHWSSSVVPMAFGMNASPSHDVYFSNSFDSSLSASNHGPMTPGQFASMPINGVVGSSNPGVSTSGQHPMSFQELGLSHVQSTQVQPMQAKQGAVQNDIRLHSMAHWPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRS0</accession>
    <name>A8PRS0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0114</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732339.1">
        <property type="nucleotide sequence ID" value="XM_001732287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRS0"/>
    <dbReference type="STRING" id="425265.A8PRS0"/>
    <dbReference type="GeneID" id="5856645"/>
    <dbReference type="KEGG" id="mgl:MGL_0114"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0114"/>
    <dbReference type="InParanoid" id="A8PRS0"/>
    <dbReference type="OMA" id="RYACEWT"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="329" mass="36891" checksum="26BC76355224DCBA" modified="2008-01-15" version="1">MSKSMDDDAAASTMTPPLSAPSKQIPLDDISTSESEPEIEDEADEKPSARSPAGSPEPAPEVRCMWEDCGETFNDLQPFIAHLHSFHIGIHKSRYACEWTGCPRKGKSQTSRFALLSHLRSHTGEKPFTCPRPECDKSFTRSDALAKHMRVQHNMPPAGQPRAGMNPASIMSDADESRDGMHEDMLDIVENERRANELETSYVLLAQRAAENGRFVLPAQETSDFEKVMAFLHNEGLVLAPSDSETDGAEPLASSARHTPPKPYLVAKAKLRYNMQRRDEWLQLVQKLQDEESELLKDCRDTLDTLLRHSYGDNVDRVFNPPKKEESMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS12</accession>
    <name>A8PS12_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732397.1">
        <property type="nucleotide sequence ID" value="XM_001732345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS12"/>
    <dbReference type="FunCoup" id="A8PS12">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS12"/>
    <dbReference type="GeneID" id="5856703"/>
    <dbReference type="KEGG" id="mgl:MGL_0172"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0172"/>
    <dbReference type="InParanoid" id="A8PS12"/>
    <dbReference type="OMA" id="KHLRHIF"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000021">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38625" checksum="6735E07764A29005" modified="2008-01-15" version="1">MASASMYQRAALAVAVATALVAVLMGVLPVAKPEWFVPGEQLDAVTRFFQSKSTSAPNITSMNASGNARATTHTNNWAVLVGTSKFWFNYRHLANTLGMYRTVKRLGMPDSHIILMLSDDIACNPRNRYPGSVWASSDRHLDLYGDDVEVDYRGYEVTVTNLLRLLTGRVPAHTPRSKRLDSDEHSNVFLYMTGHGGDEFLKFQDSEEMSAYDLADAIEQMWEKRRYHELLFMIDTCQASTMASRLYSPNVLAVGSSVKDESSYSYNTDYDVGLPLIDRYTRAVLEFMEQVTRTSTATLQDLFSSVDQVDTFSTQQVRSDLYGRPLEHVRVTDFLGSVAQVQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS21</accession>
    <name>A8PS21_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732402.1">
        <property type="nucleotide sequence ID" value="XM_001732350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS21"/>
    <dbReference type="STRING" id="425265.A8PS21"/>
    <dbReference type="GeneID" id="5856708"/>
    <dbReference type="KEGG" id="mgl:MGL_0177"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0177"/>
    <dbReference type="InParanoid" id="A8PS21"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="523" mass="58610" checksum="E8072F8EB4B1EE7C" modified="2008-01-15" version="1">MGKSSNPHQRGRGRGHGRGRGRGGSRGRGGLGNRHLDSKTSRRRGASLPFDLASIFGGKDTAAFFEIDQEMDKPKQPPSSKHRVSGRSIASRGGKRGANRAVTSHNHVPFNYSAPQSKPPLPEEANATLFASYEQDDGKLNTNSGRIKSERMNKKVKSVPEHDDDNNDEEEDEEEDDDIVIEPHKRNKGSIPHRRKLEGLVVNDLQQIVQKREYNVHAMMKHANPLLRPILFVKASGIYDKTSLLEPNNFDSLISNENMETQTGSPKSDRSQSQSKAQSLASQNERRTQNPQAPHDNIRDEKEEILSKQEPIHTDKQTSNDDEEFLSFKLADQILESSSDRKPISEQDEILADWMENAMLSGPELVPLPTMAGISDPFGDHTTLEDIAIDAHERERDAWQSDSDDENEDDDDEDVENVEDETEQDLEHGLDDSMADNELEENVDGVEEAEEFEEDDASEEIFEEELHALLLSGLGKDIPRDSKQSDEDENFLQVLRGSFPDEDVGFSSTIGQVPKKSTFALMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSE1</accession>
    <name>A8PSE1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732466.1">
        <property type="nucleotide sequence ID" value="XM_001732414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSE1"/>
    <dbReference type="STRING" id="425265.A8PSE1"/>
    <dbReference type="GeneID" id="5856772"/>
    <dbReference type="KEGG" id="mgl:MGL_0241"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0241"/>
    <dbReference type="InParanoid" id="A8PSE1"/>
    <dbReference type="OMA" id="QLSWQHE"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="484" mass="53769" checksum="9809CD8F8A45E122" modified="2008-01-15" version="1">MEQRLRESDDVFRPTALTAQNARHRENPSSPATFRPIPVPEPVAVSSIPSVTRHLHQSKPHRRVWPEPETFYGPTVPSRTTSSSHVSSTLKPRKRDADEITDAGDHDQARPVSSRRVRRKMSLEGPCRPENHQSVVVSDDDEGDLEAMDEDDVADTSTTSYDEESDLREDMKEEEMSSGSASLSSSSMEEDDLDNRDEVDVSESDEVMAPPAGFNKRSSSALKRPADTSDDHGPGDEWTDANGLRWRIGDDGIPRRAVMLIEMKPKYAMPRDTVHPDARARVPMQIERFLSHDEYEEAKRKKQLSWQHELSHAKGSVSTSSSPPSFRSDDVEDSMASIVARRSRGQARRRGANDLLFSDLTRSSRSSLSGGDDSMSNVSMGDASADDSASFSSSLLGDQADMSRRLRLSRASASPARRTASPARAVPLMRQRYARIYGASPHSQSPVRTSLDQEAKRKREKRLMSRLHAERDEAANHTSSGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSK0</accession>
    <name>A8PSK0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732496.1">
        <property type="nucleotide sequence ID" value="XM_001732444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSK0"/>
    <dbReference type="STRING" id="425265.A8PSK0"/>
    <dbReference type="GeneID" id="5856802"/>
    <dbReference type="KEGG" id="mgl:MGL_0271"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0271"/>
    <dbReference type="InParanoid" id="A8PSK0"/>
    <dbReference type="OMA" id="NEQWLMR"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="677" mass="74360" checksum="7397FA0C0AAF132A" modified="2008-01-15" version="1">MRRAQTKSPDSAENAQNKENEAKNAGESSSMRASSPWNQSPDPQAAADAGPTRPTSPGNGVPKPIALQSNEQWLMRVNRQGLPICRDLHGLFTTVVISLSDRWPDWRFPLAFVLPAAIQRMQALQFVQIVRDSANNMQNMLSLSQTKTSFTMNSDTASHICQAFIRAGLLERMAGQEDEVYTPSPKGVHLIDRFVIRHGIATRSVSNLLNVHPICDKLLFMERDEQDDVLLSDAVVRIVFHRMVGSSPRRSEPSAMGMALTTSYAKDSAGQMYETASFSSFDALQWLVQYTTLVSVDEAIVLAAHMVRLGWIEAEALMEPALSNNVATVRVDESLRADHAACEGTFIEGEVYHLTELGVTIAWKVDWVEQPASMPADERPPTSFFFGDRSNEMRSVSPRLEGFEVYGSYVHASPTEAEPRDTAKGATSATAPSATSVPSPAPGPNLDSGSVPSRSPIPEPQRIASPPLDPVVRIPITEVLRRAHVRRSFYAFLKSMRGDEVPQHEAAPVRFWCGVEWFRSDCRLATSGTLADLPDVDVVDVLPSDMDRSQHTKPGTDGMPGPKMRAIQQPVLSRSAQLRMGNLLESHALDEHISSATRDSLASALDAYVKMPSPTAEQGRDGGSSVSSHDATRKVEKVLANLLVHCAAAQKEIMKRLSQSTLSQYYDAMDNGDWDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PST3</accession>
    <name>A8PST3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase 48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732537.1">
        <property type="nucleotide sequence ID" value="XM_001732485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PST3"/>
    <dbReference type="STRING" id="425265.A8PST3"/>
    <dbReference type="GeneID" id="5856843"/>
    <dbReference type="KEGG" id="mgl:MGL_0312"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0312"/>
    <dbReference type="InParanoid" id="A8PST3"/>
    <dbReference type="OMA" id="LRTIIFH"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 48" evidence="2">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="375" mass="42789" checksum="E4C44BD38F1DB7F2" modified="2008-01-15" version="1">MPHLIYFWVSLVALCVAPFLFNPHQFAFSDFIIDYREFLRWMGRGNSRSHANSWIGYCRLSRTRITGYKKKRLGHPSEKLVADLPRASLRTIIFHEILAPIMLAVIFAVAYAYVKSFPAPGLTFEDDQFQGGISRLAIIVLVPIAWNAVVLLTLFFVSLFFGPSLHNCCAKFGSVIAGVAHALAVAGLIATLEFFWYIEYWNTANTVLGIIAMIAIQRAIFKVLTSVVISREFKHDETNRAWWTGRWYGRGLGGHAFSQPLREFIVKIIEMSMFTADFITAHLLMFALSIPLVVPFIDMIHSISLFWLRPSKQIHAPIYSLRQRAQRRSIVLRYSMVFLFAWIVFLALILVPVIVQATAYSNGDKKDLCHFCRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT68</accession>
    <name>A8PT68_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732601.1">
        <property type="nucleotide sequence ID" value="XM_001732549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT68"/>
    <dbReference type="STRING" id="425265.A8PT68"/>
    <dbReference type="GeneID" id="5856907"/>
    <dbReference type="KEGG" id="mgl:MGL_0376"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0376"/>
    <dbReference type="InParanoid" id="A8PT68"/>
    <dbReference type="OMA" id="RCITERK"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="178"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="620" mass="70156" checksum="64E6251983BA8922" modified="2008-01-15" version="1">MRSYGDLRDEATTELSQEWRNSFSDDGAWESAEDLTDSHAYISTVPPSMQHNMSQDLEAGVTVGSTPASRRKTLSQSAENSSFLDHSSVKKRPISTQTYQPRSRGMVVLHPMQAEPDDYLHIPDKNVDAHSYRPTWRGCVNVMTIAIIALALLMLFVGYPIIANFSGTFNKGKNSYLTDVKPQPLPIRGLIDPDTPKEAYTKKVATDGTDWELVFSDEFEKEGRTFWPGDDPFWEGGNFYYKATFDYEWYTPEAMVTKDGKLFITMDQYNEHNTHFRSGMLQSWNKFCFQGGYIEASVILPAKPSTQGYWPGFWLMGNLGRPGFLASTEGLWPYAYESCDLGILPYQQNSDRDGPKAALHAKTFGKTHNISSLPGMRFPSCTCADQDHPGPDRKTARSAPELDIYEIQVSDGRSQASQSYQVAPFDANYKWYGNSSSYHIYDSDITKRNPWSGGETQEALSCVTRVPDSAFFGTDAKPTIIGVEYDPDFDNQGNGYITWYMDGKPSWTLYQGALSPDEKTQISWRTFPKEPMSIIINLGISSGFQDIDWDDIQFPAHLAVEHVRVYQKPGSKRVSCDPSDHPTADYIKRNQDLYYNNNLTSFLNSSHHMMWPKNDYKDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT93</accession>
    <name>A8PT93_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 9">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0388</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 9"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732613.1">
        <property type="nucleotide sequence ID" value="XM_001732561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT93"/>
    <dbReference type="FunCoup" id="A8PT93">
        <property type="interactions" value="776"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT93"/>
    <dbReference type="GeneID" id="5856919"/>
    <dbReference type="KEGG" id="mgl:MGL_0388"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0388"/>
    <dbReference type="InParanoid" id="A8PT93"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="427"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="482" mass="52880" checksum="D54479C7FB67E934" modified="2008-01-15" version="1">MHMDVQQLEEADTDAESNRDGSNGHKCDNKVQNPGESTSSQNATAPSSSATMQIHPDCKVHANEADAISLMYQHRELPKRFDLVDLDPYGTAAPFLDAAVQAVTDGGLLCVTCTDLAVLAGHNYPEKCFSLYGGVSIKAEYSHEVALRLVLHAISMAAGRYVRFVEPMLSLSIDFYLRVFVRVWSRPETVKQNASKTGLVYTCSKCSNYHIQHMGKCTATENAKTGLTMYKFGSASGPPTDTRCAECGGTFHVGGPMWLGPLHNAMFCDELLSTLDSGRHPVHTEARIRGMVSTARDELDDALFYFHPAKVAGLFHCASPAFAPVVHALLNAGYKVSRSHCIPGSVKTNASRGQVYDLYRTWIRTNPVNPERLKDGSAAKGLLAHVRDDGSPATLHCDFDLETEHPDTQAIITGTRSENKAVRYQMNPQANWGPGTAAKGHRKRTHRSLAPEETARRTEAWRKQREAPQEGYEQPPAPSTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTD8</accession>
    <name>A8PTD8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0408</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732633.1">
        <property type="nucleotide sequence ID" value="XM_001732581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTD8"/>
    <dbReference type="FunCoup" id="A8PTD8">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTD8"/>
    <dbReference type="GeneID" id="5856939"/>
    <dbReference type="KEGG" id="mgl:MGL_0408"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0408"/>
    <dbReference type="InParanoid" id="A8PTD8"/>
    <dbReference type="OMA" id="EARFPNN"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="11">
        <location>
            <begin position="203"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="12">
        <location>
            <begin position="393"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="66118" checksum="8F534BAD43F06A76" modified="2008-01-15" version="1">MLVGQYIVQRLAQLGVKHVFGLPGDYNMQFLDMIEDENKLKWVGCANELNASYAVDGYARSTGLPGALVTTFGVGELSALNGIAGAYTEKLPVIHIVGMPTSSSQAHHVWMHHTLGGNKYKAYFEMSQNITCDSDIIGWTQRDLDNAPYVIDRLLVSMLREKLPVYLGVPLDVFEMEVSDANLSTPIEVQRPEVSDEKRDYTVQEIMRHVQAASCPMVLIDGCVSRHGVTKLAYDFVKSTGFPVVVAPMGKSLFPEDDPQYLGEYAGHGSFKELMDAMDKVDLLITLGSFDSDMNTGKFTYRTPMCHTIAIHSRCCVVGYGEFSGIGFEDVLPALSEQLKGERDQRLSLTKELKSSVEHRVELPDATFVSQDYLWTRLSSFLRPDDHIVADMGTSCFGSVHTTLPEGAHYYQQILYGSIGWSVGSTLGVLCGAEAKGKGRVILFVGDGSLMLTMQEISTMMKYGLKPIIFVLNNDGYEVERKIHGPNRSYNNIPPLDYSLLLDYMYCSKDVRAPMKAVESKEVRDEAQHSHRNDLESFKKYYHKVETRKDLDALFNDSSFQNVDGIHLVELFLRRGDAPDMLVKFTHEKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTM0</accession>
    <name>A8PTM0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732671.1">
        <property type="nucleotide sequence ID" value="XM_001732619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTM0"/>
    <dbReference type="STRING" id="425265.A8PTM0"/>
    <dbReference type="GeneID" id="5856977"/>
    <dbReference type="KEGG" id="mgl:MGL_0446"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0446"/>
    <dbReference type="InParanoid" id="A8PTM0"/>
    <dbReference type="OMA" id="FKHNVID"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="47926" checksum="72FAE6D3CFCBF12E" modified="2008-01-15" version="1">MAPDIWGDLLRGARARHAFVSKTIVVLGEPSSGKSILVRQLVGSDQARASGPKETSGPLGFGFIELSENDKTDESLRTSVYTVHSFGSSIAATLPYAFPPVQTAPDASAMGALHRMRETIFLIILDWSKPWTFAAQLVAWFRLLRELIQQAYVAGQEHSADTERATMRENLETHLFSNADDVRPPGMLTDNLGVHIALVCTKADCLDSAIKERRLSDSQIDSLQQFLRTVAMCYGAAIFSTTITRASSYDALRAHVRHTLYPDTSEANGTSTVEASTADTRHLLVPAGWDSWSKIEAIDESFSCRTWHDAWIHDITSSSPLDATPRIASMCAELVPPPPMDDANHQSSVEVPSEQTFLAQLQAHQPPDDSNITASAHGAWKTAQTTPARNAIGPSMHASTLDVPSIGRVWKSKHEKCLCHHRLHRRRDRTMCARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTV4</accession>
    <name>A8PTV4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732709.1">
        <property type="nucleotide sequence ID" value="XM_001732657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTV4"/>
    <dbReference type="STRING" id="425265.A8PTV4"/>
    <dbReference type="GeneID" id="5857015"/>
    <dbReference type="KEGG" id="mgl:MGL_0484"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0484"/>
    <dbReference type="InParanoid" id="A8PTV4"/>
    <dbReference type="OMA" id="NTTHEDT"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="343" mass="37992" checksum="DFF8D4D38447D786" modified="2008-01-15" version="1">MQECALLTACQFHMPDATSDERMYALVQLEHAVSQRVLHELPKVRQQAKENGTRRAMFFIQVERCCDWAVYHHGVRTCLAEHLLSLLGRLHILLKLSPTASDDGNSLASEMGCALSILQGVCLTNETSRQLCSSKSSLALFLGIVKAEYSQSNDSSCALGLLIPHTLDTLMCILVDAPTDVRRAFEHAHGLSIVRRVMNARPSPSADAANMDTTGAKCIEFLLFYLQAKEFEQQASQQLSGSTAQSVFRPPETPKPKRGHARSRSAITATPFYTPLATPRSRQQRVLSYGSPTKHVAQGKLAMPPEANPFLHAQSRVRERESSDMLQTPRASTRHLDRETSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUF6</accession>
    <name>A8PUF6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732082.1">
        <property type="nucleotide sequence ID" value="XM_001732030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUF6"/>
    <dbReference type="FunCoup" id="A8PUF6">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUF6"/>
    <dbReference type="GeneID" id="5856388"/>
    <dbReference type="KEGG" id="mgl:MGL_0675"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0675"/>
    <dbReference type="InParanoid" id="A8PUF6"/>
    <dbReference type="OMA" id="YAGHANI"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="546" mass="58122" checksum="2A6DA4A27F0B1DE0" modified="2008-01-15" version="1">MSAFRRFTSSPSHARKAPEGVRSAPYDAPVPLLSTGIPALDDIMCGGGILAGSMLAFVPCASTANESAAMLGAPMLGGDLHATYDDAAYSAAEAYTDLFLGYVTAEGLASHHVNVVIGESAEAFVSQLMSQADESEETSSSAGSKVSASSSSKPKDSTHVAEDMQRMKIAWRYGQQPREMRKHSLPSATTSHVFDLSRRISPDTIRQAKAEQQLTTVSLDTEDPFRVAWDAILQAVEHCKIASHTRTPVLRIDLRAFGSPMWMSPSTHSAEAIRFLLRLRSLARTLSMPMPGSTIPPIPTLVSLSLSSHVYTFRKDAQQGINLAHRLMHLMDGCIGLSSFAAMPGLSDIFPDFMGAVRVYKTPSIGTLTNPSLRASILRGMGAGASLESGANEGGAGGGENNLAFKIKRKRIAIETLHLDTDGGVNERRTTPHPFSTSHSVGVTSAEAETAGAKHSDRSLSSRSTVPAPVSASMSSSADAHADERQAASPQVRSPSPSQPQPQSQQPATRSGPRLFTGLGDLRQRGLHVAKDASFPSVGRPQDYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUG6</accession>
    <name>A8PUG6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metal-dependent protein hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732089.1">
        <property type="nucleotide sequence ID" value="XM_001732037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUG6"/>
    <dbReference type="FunCoup" id="A8PUG6">
        <property type="interactions" value="880"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUG6"/>
    <dbReference type="GeneID" id="5856395"/>
    <dbReference type="KEGG" id="mgl:MGL_0682"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0682"/>
    <dbReference type="InParanoid" id="A8PUG6"/>
    <dbReference type="OMA" id="FHCDEVV"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38408" checksum="46ADB59EA077CF73" modified="2008-01-15" version="1">MSDAKRIKLESSHRPIIVTHSGTFHADEALAVHLLSKLPVLHDAELIRTRDPAEIAKGTIVVDVGAEYVPEKHRYDHHQRGFSETFDAEHKTKLSSAGLVWKHFGRDILTAHLNCSADDKRIPVLYKKMYDDFVEAIDGHDNGIPLYPGVSEPPAYRSRTDLSSRVSYMNPRWNETWDDADLLARFRRASSMAGSEFFDRVNDAVDGWFPARQLVVDALHARKSFDGADEKGRIVLFQRAVAWKSHIFDLEESMNIPDDEKPLYIVYPDESNKWRVQAVPVNLESFESRKALPEAWRGIRDEQLSGLSGIPSCVFVHQSGFIGGNQTKEGALTMAKKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUW5</accession>
    <name>A8PUW5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0787</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732194.1">
        <property type="nucleotide sequence ID" value="XM_001732142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUW5"/>
    <dbReference type="STRING" id="425265.A8PUW5"/>
    <dbReference type="GeneID" id="5856500"/>
    <dbReference type="KEGG" id="mgl:MGL_0787"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0787"/>
    <dbReference type="InParanoid" id="A8PUW5"/>
    <dbReference type="OMA" id="HAVVRIH"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02164">
        <property type="entry name" value="PPAT_CoAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="235"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="715"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="874"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="882"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP44980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="913" mass="101050" checksum="5F7F008451A3CFE5" modified="2008-01-15" version="1">MSRPVTFEYLSCAVNRTSHIAEWIQLHDVHDALVFGVHKSVAMWFDPSGHETPASSTSASNTTRSAPIPKLHLWPTQFQQLVHVLKVWHLHHDVPHLLMGSYDGALEMWRWSADDWQWTSEAFIPRAHNASVTAIGVPRDVHSCEYAPREFVTGGSDALLHVWSCSSQSVSTSATEPVQPQIVQTIDLCGAYPLDIALVRLPHTQTTLMAVALTDRRISLYVRSDGGSFTLQLRLDGHEDWVRALDFTVAWPHVWLASAAQDQHVRLWKLYAEEQAAQAMQESQAPPPDFFEAMARELMPNDQGIKTKTEWLTLPGERWGISLDALLLGHDAWVTDVRWVPNKQGQEATQRAALLTSSVDNSVIVWTPDASSDWPKLTDASAAEQSMWLPAHRLGDVGSMSGGFLGAHWRPHATDISVISHDRQGAVHLWKRTAMHKWEPQATISGHAGAARDAAWEPNGDAFLTVGVDRTTRLHGTYLHDETRSWHELARPQTHGYDMQAVSWLDRTSFVSAADEKILRVFAAPASFLDSANACRMWQTSHHRRVTHVLALSVHSPDQWYAGPKLRRAIEAVMTQARSKCLSVVIWAGTDAISMSGAEHLLQCVYAQAWAWAVRRNDLLWDISVYVIPASSDSEHGAHLWTQWSVAHAPIASLSTLDDPAFDVHAPTLTHDVTCPLTRLPLDVDASTAIDPAQQQQQPQQQQQQHVSVCGDTAVLGGTFDHLHIGHKLLLSMAILSARKELLVGVTSTALLVNKKHREYIEPLHVRMAHVRAFVRDQCTALGKSLQLCVVPISDPCGPAATQPDLDVLVVTDETVRGADLIAEERRKNALRPLQLYTVRLVQGDNSTADASVKASSTDIREWVARNNIKPGDEYEAAVRDSSTTTPTQPSLSLSERAPAAHVPPLGTLESGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV89</accession>
    <name>A8PV89_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731555.1">
        <property type="nucleotide sequence ID" value="XM_001731503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV89"/>
    <dbReference type="GeneID" id="5855870"/>
    <dbReference type="KEGG" id="mgl:MGL_0823"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0823"/>
    <dbReference type="InParanoid" id="A8PV89"/>
    <dbReference type="OrthoDB" id="2556847at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="329" mass="34136" checksum="FE5C35A2F9470EF0" modified="2008-01-15" version="1">MTASLEHIERLIHEDEMKSFQDLTTELRKARSELEEIERQRPWVMPVIKGTDASTSTTTSSPASHDARPSSPAARSDHTPDAHQDRLGASSRPFPIVRPPSHDNRPTPLPSTNPPPLSPPPVSNLAVLSANNGSPSPATSMPSRQSPLQAPGAATTALATAVPCGTATSMTPTPATPMPVSGSVAPTPAGTMNGMSSLNTTESLTKTSIPTQPLPLVVPIACVPRLTALGINLVPAPHLVPALSLASAGQSVAMNAGLTAPRPVIGAQNEPVLLVGITDAPASLPPAANQASRQRLHLSVVLSKLRPDQLSGLANIMQSLQADDENTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV92</accession>
    <name>A8PV92_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731556.1">
        <property type="nucleotide sequence ID" value="XM_001731504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV92"/>
    <dbReference type="GeneID" id="5855871"/>
    <dbReference type="KEGG" id="mgl:MGL_0824"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0824"/>
    <dbReference type="InParanoid" id="A8PV92"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="265" mass="26610" checksum="13F962B238567649" modified="2008-01-15" version="1">MSDAGERAPPDPAPATDASTSSPSVQTHVQTPIEPLHPSTNAPQVRAAPSSVQAPPLYTRSTPPTPSPASSYASPVVTVRMNATQPPSMPPTPVSRGVINTGAGVSSNGSVSPALAPGSHANASSHTSGAVKPISTGLASPASPAPRPPFIISNALAAASGLGPIPRRGTTATPATVTPSAMSHRTHTPSPIPVNSSISSRPVANTSTATSTHASPTTQQMPAPPPPPPQSAAAGDIRPVRLPPHKDLISEDAELAAQRARTRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVF5</accession>
    <name>A8PVF5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731580.1">
        <property type="nucleotide sequence ID" value="XM_001731528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVF5"/>
    <dbReference type="FunCoup" id="A8PVF5">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVF5"/>
    <dbReference type="GeneID" id="5855886"/>
    <dbReference type="KEGG" id="mgl:MGL_0848"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0848"/>
    <dbReference type="InParanoid" id="A8PVF5"/>
    <dbReference type="OMA" id="FETKAKM"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="377" mass="42907" checksum="09D2F5735DA05C87" modified="2008-01-15" version="1">MVPKFMMANGEIVNMLVHTDVTRYLEFKQISASYVYRDKRIAKVPSTEIEAVRSPLMGLFEKRRAKRFFEFLQKWRDEDPSTHQGIDLDEWPMEKVFAHFGLEPGTRDFIGHAMALHLEDSYMKRPARETYERILLYMSSMARYGKSPYIYPLYGLGELPQGFARLSAIHGGTYMLDKPVDEIVVDNKGHFVGVRSGDETVKANLVVGDPSYFRQVGGKSLVRETVKVVRAICILKHPIPNTDNSDSVQLIIPQNQVGRKNDIYIAEVSSAHNICAKGIYVAQVSTIVETDKPELELRPGLDLLGEILDKFVTVASLEEPLDSGRDSNIYITRSYDPTSHFETVVEDIHDVWRRMTGHPLVLKKRQEQEEDGAQVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVH5</accession>
    <name>A8PVH5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase</fullName>
            <ecNumber evidence="9">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0868</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731600.1">
        <property type="nucleotide sequence ID" value="XM_001731548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVH5"/>
    <dbReference type="FunCoup" id="A8PVH5">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVH5"/>
    <dbReference type="GeneID" id="5855906"/>
    <dbReference type="KEGG" id="mgl:MGL_0868"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0868"/>
    <dbReference type="InParanoid" id="A8PVH5"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="11">
        <location>
            <begin position="78"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="397" mass="44776" checksum="E57CD42EF8D02FDD" modified="2008-01-15" version="1">MDAYLLWDRPPNSVTPFGPEYLLDASKSRQSIDPNHFDDPDATPTPSPTWIDSQEASPNQGWVNSDYAIFRPTPLVSPWNQPLVDELECVRMHRRLTRDAHSEMAYLRAASAVKAAPYPLKALDEMQLKAIKGIGPKMITVIQQFYEHGYIPEAEIIRNDRAVQTMFHFMKLHGVGPHMSERLYKEGCRTLEDVILTGKMEFANRLGPSISLSMLPDLLRPIPRAQVECIRNDILRVLDGLVSNAQAVIVGGYRRGKELSGDVDLVVSSSSEESATTLLHALVHSLRDAGKVSHTLALSRHTEDHRLVDVAEIVYADTSSGKQMHRRVDIVYAVRAYLGAAILAWTGSSLYERDLRRWAQTRGYSVRAGCLHKRECGLTMKTSFHKLDCFIFSHRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVU8</accession>
    <name>A8PVU8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731692.1">
        <property type="nucleotide sequence ID" value="XM_001731640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVU8"/>
    <dbReference type="FunCoup" id="A8PVU8">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVU8"/>
    <dbReference type="GeneID" id="5855997"/>
    <dbReference type="KEGG" id="mgl:MGL_0960"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0960"/>
    <dbReference type="InParanoid" id="A8PVU8"/>
    <dbReference type="OMA" id="TRMYHID"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="208"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="927"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1102" mass="119085" checksum="2EAA009CAD153B8A" modified="2008-01-15" version="1">MYGVADAFFAGGSGTSPSSSLHALQQLIRPKTTQPPQSGLFQSCLQLGERLARVPGFERDFPLRSKSKRRDSSSSTGSSSEPHDPVSQLWQYFRQGKPLCVLFNVYATYAHIAPISYRVESKLSNANACKALVMRFILALKERLGWDPEDTFTVSQLYLSDTNGFVRVVRTLDRFLLLLEDCGLLHPTTPVPSEELPPQPPVACPRDQRELVGMELLESERKYVHDLEILQSYASAISQYDIVSQDTIYHIFGNLDQLVDAQRRFLICLEQNAQKPLESQQLGYIFQSLEDDFSVYDLFCANYANALQYINDERAALSQLSQIPAAQSRYLEPSYELPTFLIKPVQRICKYPLLLEQLLKHTPEGAPGHADVVEALATIRRITDKVNETQRSQENEQVVKNLEARVEDWKGHSLRTFGSLLLSDTFVVSKGDSEREFGVYLFEHILLCCKDTSTSAPYQLSLTPGRSRSKSGSRLRQRGGSMSESSASRREQQKPGPLQLKGRIFLSNIVAIQVLGRRASSSSLSAMPTESIGPYTLQVWWHGELELESFCLRCKNEEQLRMWYSTMQKLLGELRARRQASASQASTPVTTQAPSLPGSRPGSGHSKGPASAAFMQVSTPVVSYAQDTMPMRLRRSNTAECNDALLGRSARTSSNPSLKTSFNTPSVSDCDSPRDTPCDDAAPFGLPHGLLASPVVPGRPPPPPAHNLVGSGASGTNHPCSSTAPGAGVGAGPGLSIGPGIGSGLASASSPAMYPPRMPWRQRSLGNIHQHPFMTSSSTTPIPTPGAAPSSASTAAPAPAHASATATPPAVPVKTPNRVPIPVRSSSVSGNMPPLRASAEFLEKEMEAMKLSKALKPLRGFAAARGGPSPMRLDSTIMQPPLSVGQTVPPNSDWALTYGHVSPTTEWNPYFPMMTSGATHAPPPSATLPASAVAPGPMGAAGTSATSAASIAAPSGIATKRQDSFSTTGSRVSADASQANTPSVSHSPMTRQNSSSGASGTGSSSVWMRSAPHSPPITMQVRVCVRYGPERVELQVPNTVSFSNLHALVHSSVRVAPEAHTRMYHIDEDGDRVMLLDDDDLATAMEHVRRVQSEPHLVVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW22</accession>
    <name>A8PW22_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731741.1">
        <property type="nucleotide sequence ID" value="XM_001731689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW22"/>
    <dbReference type="FunCoup" id="A8PW22">
        <property type="interactions" value="586"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW22"/>
    <dbReference type="GeneID" id="5856046"/>
    <dbReference type="KEGG" id="mgl:MGL_1009"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1009"/>
    <dbReference type="InParanoid" id="A8PW22"/>
    <dbReference type="OMA" id="ISGCYAR"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plus3" evidence="2">
        <location>
            <begin position="226"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="543" mass="60042" checksum="F63BFB5C77C155E4" modified="2008-01-15" version="1">MNELEREDVLTERRDEISRRQQQAQLAAMVRTQQAAAASKSRRQSFSSSSRSKTKSSSSSSSSKLSDAQREKRRRSDVRRELEDLDDPFAEDESDQDVFRESDEEDGEEEEEDAGDNAGSRRMARRKLASSSSTKADKLSELRRKRAERAHGRASRAGDGHVDDNDQGDDDDDDDYARGVRGPPRRRRRVSLSDSEYESESDYEPAYLPRRAREESPILSASSKEPPSLEQLNSVRVGRDDLERLLFLPNGTDLVRGCFVKCSWGMRESPRGGKEHVYRVHQILDVQQRDKYYDVSHDHAGRWMNSYVTFRWGGKDHHVDLRPLSTQRITDSERQRWIAAAGADAKFPSADAFRSKQMQMESALSTPLTEDDIKKMLERKRELRQAAESLGLHVTRLSSDSAPSQAAGMPFSTAGSEGSGAYGTGVKHFDEHAMAQINERNRRLDRERIQEAERRAARAKRAMVSNASATGAETGAQHDASATVSTTGVDSGAGANASESASAAPDGQDHAGSMPHAPVSAILASAPAGSAVVPNMEVDLGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW95</accession>
    <name>A8PW95_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731784.1">
        <property type="nucleotide sequence ID" value="XM_001731732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW95"/>
    <dbReference type="FunCoup" id="A8PW95">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW95"/>
    <dbReference type="GeneID" id="5856089"/>
    <dbReference type="KEGG" id="mgl:MGL_1052"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1052"/>
    <dbReference type="InParanoid" id="A8PW95"/>
    <dbReference type="OMA" id="VENHIHI"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="38"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="119" mass="13506" checksum="B70BF095B25F159E" modified="2008-01-15" version="1">MSIQNLASYDPFADVGDELAPKELAEETKKTSQVNSYVHIRIQQRNGRKTLTTLQGLPKEYDPKKLLKAFKKEFACNGTLVDDEELGQVIQLQGDQRQKISMFLIEEGIPKQDVKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWE8</accession>
    <name>A8PWE8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731814.1">
        <property type="nucleotide sequence ID" value="XM_001731762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWE8"/>
    <dbReference type="FunCoup" id="A8PWE8">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWE8"/>
    <dbReference type="GeneID" id="5856119"/>
    <dbReference type="KEGG" id="mgl:MGL_1082"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1082"/>
    <dbReference type="InParanoid" id="A8PWE8"/>
    <dbReference type="OMA" id="RIGVCYS"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="198"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="278" mass="31387" checksum="AE513D88E59F4824" modified="2008-01-15" version="1">MRGVWTPGLWCHAHVYHGSIGSLHPSLLRCAVRSIHTRRKPITIPESIKLSILDFPPQPRPTRPLSALMRRAKTLVFNGPKGEVVVPLHHFVNMVWADNPETKQRNVTFAVENEDIKLQRGIWGLTRALCANAIKGAQDGHEVTLRLVGVGYRASIEPDPLPRKHPLEVELERGRGHWYAAEQKQTEIDRVKRLIEASGPNQRLHLRLGYSHPVLVPIPYGVQAETPSPTTIKLSSANKELLGQFAQSVRQFRKPEPYKGKGVFINDEQIKLKTPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWG0</accession>
    <name>A8PWG0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin-19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731820.1">
        <property type="nucleotide sequence ID" value="XM_001731768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWG0"/>
    <dbReference type="STRING" id="425265.A8PWG0"/>
    <dbReference type="GeneID" id="5856125"/>
    <dbReference type="KEGG" id="mgl:MGL_1088"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1088"/>
    <dbReference type="InParanoid" id="A8PWG0"/>
    <dbReference type="OMA" id="YEPMREM"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="40414" checksum="D137643E431E382E" modified="2008-01-15" version="1">MTPPKATADDLDDLDGTWLYEWLTQLIDVLDDFEAPMANHAPELAKERTQTNSSNGSGAAANVKGSENRVDGDANAGMGEGEDPLSDEFVEELTKNMESFMAQLGKDMSTHKDAKAPPLSSGRASESESGGAPPPAEDELMKQFEKLLLSSNLEGLDRDTMPSLSKSQTQAASKHGSETHEERATGSSDASGEKSFQDAVKATMDKLKQSNASANNSSSNSDASDPLAALGLDGNADFSKILEALSQPGEDGEGSLSKMLAQMMEDLMNKDVLYEPLKDMHSRFPAYLASPAAEKLDDDTRQAYVAQEATMGEIIAVFESSNYSDSNPEKRKQVADLVSKLQEFGTPPQELLGDMPPELAGLNQMLGESSDENCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWK3</accession>
    <name>A8PWK3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Glutathione reductase</fullName>
            <ecNumber evidence="2 14">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_1130</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="2 14"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731862.1">
        <property type="nucleotide sequence ID" value="XM_001731810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWK3"/>
    <dbReference type="FunCoup" id="A8PWK3">
        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWK3"/>
    <dbReference type="GeneID" id="5856167"/>
    <dbReference type="KEGG" id="mgl:MGL_1130"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1130"/>
    <dbReference type="InParanoid" id="A8PWK3"/>
    <dbReference type="OMA" id="GTCINWG"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="16">
        <location>
            <begin position="12"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="15">
        <location>
            <begin position="365"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP44648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="481" mass="51853" checksum="56832C1D512610E7" modified="2008-01-15" version="1">MPPVKIPASEHYDLLVIGGGSGGMGASRRAASYGKKVAVIEQAGKLGGTCVNVGCVPKKLMWHAADLQDKLKEAQEYGFMDASGSFAVPTVNWNMLVEKRDAYIRRLNGIYDNNLKKDNVEYISGHGRLLGNGRVKVSPGVDGVLEKEVVLSADHIVVASGGRPSVPSDDEVPGASLGTDSDGFFAWREQPKRVAIVGAGYIAVELAGVLNALNSETHLIIRHDQFLRNFDPIISETLTQYMGSTGLQVHKSSNVKRVEGERGGSLKVHLDTGNTIEVDALVWAIGRQPNTDDLGLDEAGVKTDKSNNIEVDKYQNTSAKGVYAVGDIQGKALLTPVAIAAGRRLSNRLFGGPKFKDDHLDYENIPTAIFSHPATGTVGMSEPEAREKFQGQKITIYRSRFTPMYYGLLSKKAPAAYKIVCVGEEERVVGVHMVGMGSDESIQTVGIAVKMGAKKRDFDNTVAVHPTSAEELVTTYVPVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWR8</accession>
    <name>A8PWR8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Chitin synthase</fullName>
            <ecNumber evidence="3 13">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1195</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3 13"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731927.1">
        <property type="nucleotide sequence ID" value="XM_001731875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWR8"/>
    <dbReference type="SMR" id="A8PWR8"/>
    <dbReference type="FunCoup" id="A8PWR8">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWR8"/>
    <dbReference type="GeneID" id="5856232"/>
    <dbReference type="KEGG" id="mgl:MGL_1195"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1195"/>
    <dbReference type="InParanoid" id="A8PWR8"/>
    <dbReference type="OMA" id="RYGAQPM"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="805"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="14">
        <location>
            <begin position="113"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="837" mass="95501" checksum="4F0F1113D982500B" modified="2008-01-15" version="1">MCCGHTDHTSLSIYGTDMHYSDMGTTENDMPYLEPEYAYSKEAWSATMPPDEDPNQTQTRLLGAPENMTQEILEPTAYYAQNMPDRCSVYDDDEEKRIIHYGHIPQRQPRRYRTIKRVPLHDGHLVLDCPIPPRLMRRLPIREGREFGYMRYTAITSDADSFVPDRYSLRQQLYDPPRSTELCIILTMYNEDEQLFTRTMHGVMSNIAHLCSLRNHSTWGEGSWKKVVVLIVSDGRNKIHSRTLSVLAAMGIYQEGIAKSAVQGTPVQAHMYEYTAQISVDSSLKFRSAERGIVPVQMIFLLKEQNRKKINSHRWAFNAFGPLLNPRVCILLDVGTMPKQRSIYHLWRAFDSDPNVGGACGEIVVQKGLLWHALFNPLVAAQNFEYKMSNVLDKPMESAFGYISVLPGAFSAYRFAALQNDPMGHGPLHSYLKGESMHGGHDDVDIFTSNMYLAEDRILCWELVTKRNAAWVLRFVKRAQAETDVPTHVAELMSQRRRWLNGSFFAAIHSIIKFGRIYRSSHSIGRKILLHIEMLYQVFMLFFSWFSMANYFITFFILAESMQTIAHWIRVPALICEYIYLAFIIYCFLLSMGNRPQGNRVGYLVSMIVFALFMLIMMVFVVFLAYWGITHELESHDDVSILKDGVFVRIVISVISTYGVWLLASLLFLDPWHMITSLFQYLLLSPSFINVINIYAFCNTHDVSWGTKGSTTLTSDLGQASGPSNDAVEVTIPNESQDVDAAYEDACQILSSKPPSRSLFLKEDTSQAQMDYYATVRTNVVLAWTLTNVALVIGIINLSHEVHNVYMAVLFYSVAALAFFRLLGAIMYMLGKLLPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWT0</accession>
    <name>A8PWT0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731938.1">
        <property type="nucleotide sequence ID" value="XM_001731886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWT0"/>
    <dbReference type="STRING" id="425265.A8PWT0"/>
    <dbReference type="GeneID" id="5856243"/>
    <dbReference type="KEGG" id="mgl:MGL_1206"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1206"/>
    <dbReference type="InParanoid" id="A8PWT0"/>
    <dbReference type="OMA" id="FNEAIWH"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="149" mass="16814" checksum="95F903347B06715B" modified="2008-01-15" version="1">MPLVTAGAGADAHFMRRFATAGCDAVVKIWEFSDEHNRYIEIDQLKQHRDWVRDVAFAPSLGLARTYLATASQDRTVLIWTQNTPNDPWKCTPLLPSTKPEDRTKFPDTVWRVSWSVSGNVLAVSCGDGKVSLWKENLKGAWECISEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWY8</accession>
    <name>A8PWY8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731996.1">
        <property type="nucleotide sequence ID" value="XM_001731944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWY8"/>
    <dbReference type="FunCoup" id="A8PWY8">
        <property type="interactions" value="524"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWY8"/>
    <dbReference type="GeneID" id="5856301"/>
    <dbReference type="KEGG" id="mgl:MGL_1264"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1264"/>
    <dbReference type="InParanoid" id="A8PWY8"/>
    <dbReference type="OMA" id="YRWYKHI"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="6">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="5">
        <location>
            <begin position="133"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24347" checksum="EEF5ED6139F6FEFF" modified="2008-01-15" version="1">MSLPDFSNADTLSKFESFLTSKSYIDGHEPSQADVAVYEAIKSPVDSNKFPNVSRWQEHIKSFEAEHANLKGDKSKAAELLNFGAAAGGDDDEVDLFGSDEDEVDPEAERVKAERVKQYEERKAAKGPRPPAKSVVTFDVKPWDDETDMTALEKEVRSIEMDGLVWGASKLVPIGYGVNKLQITIVVEDDKVSMDDLQDRVQEIEDYVQSSDIAAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXS9</accession>
    <name>A8PXS9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731334.1">
        <property type="nucleotide sequence ID" value="XM_001731282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXS9"/>
    <dbReference type="FunCoup" id="A8PXS9">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXS9"/>
    <dbReference type="GeneID" id="5855641"/>
    <dbReference type="KEGG" id="mgl:MGL_1517"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1517"/>
    <dbReference type="InParanoid" id="A8PXS9"/>
    <dbReference type="OMA" id="EASHAEI"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000162">
        <property type="entry name" value="septin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="8">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="346" mass="40636" checksum="2A568A3FB6D9CAEA" modified="2008-01-15" version="1">MTTTTTEPIVINTLFRTELAPGTNYAQRHSTQLDKAVEVDVIRAELEEKQFRVNLTVIDTPGFGDYVNNRDCWAPLVDFIDDQYESYMRQEQQPERKQLHDQRVHACLYFIAPTGHTLKPLDIEVMKRLSQRVNLIPVVAKADTLTPRDLALFKERIRDVIRTHGITVFAPPVDSIDEASAEHARALMSSMPFSIIGSTKDVRTYDGRMVRGREYLWGVAEVENEHHCDFKKLRSLLIRTHMLDLIMNTEDYHYENYRQTQMETRKYGEPKVKKFDNPRFKEEEEALRRKFTDQVKLEEGRFRQWEQHLIAERDRLNKDLETAHGAIKQLESEIESLQMASRTQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYA2</accession>
    <name>A8PYA2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731439.1">
        <property type="nucleotide sequence ID" value="XM_001731387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYA2"/>
    <dbReference type="FunCoup" id="A8PYA2">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYA2"/>
    <dbReference type="GeneID" id="5855746"/>
    <dbReference type="KEGG" id="mgl:MGL_1622"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1622"/>
    <dbReference type="InParanoid" id="A8PYA2"/>
    <dbReference type="OMA" id="MQAHVCA"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="293" mass="31386" checksum="7F9E831A24F9E3FA" modified="2008-01-15" version="1">MASSFSHKAVPALDVFKPDLFHGKVVLVTGGGSGICYHITETLMRLGCKAAIVGRKADRLREAAEQLARDTGSEAIATPGDVRKFEAMEQVVKQTIDKFGKIDFVICGAAGNFMAPLEGLSSNAFRTVLEIDLVGTYNTVRATMAEVKRTHGTYLHISATLHYSGLPWQAAPSAAKAGVDALSNVICVELGPFGVRSNCIAPGFIAGTEGASRLVPKGSDDMVKAFIPAQRIGERTDIANAAVFLFSEAANWITGQVIAVDGGQMHFRSAWLPYPQSSLDPRSFKNLFPDLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYA6</accession>
    <name>A8PYA6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731441.1">
        <property type="nucleotide sequence ID" value="XM_001731389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYA6"/>
    <dbReference type="STRING" id="425265.A8PYA6"/>
    <dbReference type="GeneID" id="5855748"/>
    <dbReference type="KEGG" id="mgl:MGL_1624"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1624"/>
    <dbReference type="InParanoid" id="A8PYA6"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="283" mass="31881" checksum="B481820B29A6C2E3" modified="2008-01-15" version="1">MTGLTFASWWDAANACHNDDPWSDPELYAFVCDGTQIGFLPAKVWNVVCRYVEEAQIPLQLDATTRVMTFSCSCNSFDARTMAINRLAQLLRENGEFPDPLNACALFGLATFGVHLTAFTPDGRIWVPKRSETKATWPGRYDNTVGGGISAGDTPYDTIVRECGEEASLESEFVKKHLRSVGVITYFYKTELGFRQPEMQFLYDLPLPTNDVVLAPNDDEAQSFELMDKDTVLHHIYANEFKPNCTLVLLDFFIRHGWLTPDNEPNYTKLAALLHTPLRLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYP3</accession>
    <name>A8PYP3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1699</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731516.1">
        <property type="nucleotide sequence ID" value="XM_001731464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYP3"/>
    <dbReference type="FunCoup" id="A8PYP3">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYP3"/>
    <dbReference type="GeneID" id="5855823"/>
    <dbReference type="KEGG" id="mgl:MGL_1699"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1699"/>
    <dbReference type="InParanoid" id="A8PYP3"/>
    <dbReference type="OMA" id="WQQEGFN"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cux N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="11">
        <location>
            <begin position="360"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="181"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="441"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="544" mass="61837" checksum="064B959AF72834DF" modified="2008-01-15" version="1">MPDANALSILEAWKNVKLEGFLNDLQAQTGTIADAQKEALLARKNLADRTREFKRQAPETQLEGIRGLLKSYQSQIDALTTRAKQAETIVLDAHARLGQVRDPSPLLDILREQISEAQDGAELRKKYAHLWTERNELEQRYTESEARAVTLSEQAVQASTHAEQMIADAVAAATRRAAEKQESLERELVATQNHLTELRASHEQLTQQLLAPRASNQDSQHMESVLIDLQRANERAIQAEQRMAFLRDETEKAQASATDSFSRRVAALEQRMQQQVQAHSQQVKALELARQAAQEEAAKQNDAQLQRLNATLDECAQIRKALEQRSDYDEIKRELDVLRAVEFAGDEAMSDAVEDNASSLEAHLVRRNHKLQDEVATLRATLADTKRSADSLREDLSGQLQRVSELSAANAKLEKDLLDFSPNGPVQSDMKDLLPIVTGQRDRFRSRNAQLEESMRQQNQVISELRTEVKRLQTDNVSMYEKVRYLQGYSQHQRTDSAYPPYKPVEAEEAYRVTYEASIHPFEAFRGRVREPVFFIFALFFSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYQ3</accession>
    <name>A8PYQ3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor IF2/IF5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731521.1">
        <property type="nucleotide sequence ID" value="XM_001731469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYQ3"/>
    <dbReference type="FunCoup" id="A8PYQ3">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYQ3"/>
    <dbReference type="GeneID" id="5855828"/>
    <dbReference type="KEGG" id="mgl:MGL_1704"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1704"/>
    <dbReference type="InParanoid" id="A8PYQ3"/>
    <dbReference type="OMA" id="QIMREGN"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="174"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="305" mass="34184" checksum="5237942FB4878940" modified="2008-01-15" version="1">MSAAPTEEAAAKEAPPVQPEAAQDAADLFGGLKKKSKKKKTPADIDLGETKSEKPESENQSEAPEEKGTDALADDAPLDFGDLKKKKKKKKAAFDLEEFEKELGESRDADNVDGTASGADGDKPIDVKEEAPESQMSQDAETWHDSDRDYTYQELLHRIFRTLRQQNPALSGEKKKYTMVPPVVQRDGSKKTMFANVIEICKRMHRQPDHVIQYLFTELGTTGSVDGSQRLVIRGRFQPKQIENVLRRYIVEYVTCKTCRSPNTLLTKENRIYFMTCEACGSQRSVSAIKTGFQAQTGKRSKMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ38</accession>
    <name>A8PZ38_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">37S ribosomal protein mrp10, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730886.1">
        <property type="nucleotide sequence ID" value="XM_001730834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ38"/>
    <dbReference type="FunCoup" id="A8PZ38">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZ38"/>
    <dbReference type="GeneID" id="5855193"/>
    <dbReference type="KEGG" id="mgl:MGL_1885"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1885"/>
    <dbReference type="InParanoid" id="A8PZ38"/>
    <dbReference type="OMA" id="AAMLGCW"/>
    <dbReference type="OrthoDB" id="2210at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8816" checksum="D7BD181DF397B7B2" modified="2008-01-15" version="1">MKFEKLKVRPKKLASKAPCAAEFASVLACWASTQDLRSQSECVGVTKTLRECMATAHQGPRKQAKPTINYHLARFSKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZS0</accession>
    <name>A8PZS0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730945.1">
        <property type="nucleotide sequence ID" value="XM_001730893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZS0"/>
    <dbReference type="STRING" id="425265.A8PZS0"/>
    <dbReference type="GeneID" id="5855252"/>
    <dbReference type="KEGG" id="mgl:MGL_1944"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1944"/>
    <dbReference type="InParanoid" id="A8PZS0"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="136" mass="16265" checksum="A3F9B8049EAC37DC" modified="2008-01-15" version="1">MHERIFELLEQNMKALYDETSSWDPWLKRDELLHPKSRFLLAFEDHENTLTFQGVAQRRSGRFCEKPQTQHTLQGFVMWRFDTDDTVPEDPYSLQGESDVEVAYWYVEMLEMMIQKADSLLIVTRCKWRVNGKVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q067</accession>
    <name>A8Q067_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730990.1">
        <property type="nucleotide sequence ID" value="XM_001730938.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q067">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q067"/>
    <dbReference type="GeneID" id="5855297"/>
    <dbReference type="KEGG" id="mgl:MGL_1989"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1989"/>
    <dbReference type="InParanoid" id="A8Q067"/>
    <dbReference type="OMA" id="CFLAGEF"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1168"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1168"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1211"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1238"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1324"/>
            <end position="1367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1367" mass="148768" checksum="BD21E15285FDA527" modified="2008-01-15" version="1">MSGDGGGDRAGAHKDIKYAAMPKSLELVLATNESLTIELDPLPDAEELDVVMDVLVEEKPPAYFWTALASRCWNAGRRAEAEQIISRGCSILPVHRPQECASLFALRAAFLLAEARTAPKQVLDDARYQPLGERSPKQHYFQQVHDNWQRVQSLTSPAEQQSSRVLLQVRAVTALMCGDNALAAKLFDALLARTPSDVVALLGRACVLLRARQYHPALHTYQHALRVMLRMDQAAEAQQEPSIAWHGADPRIGIGLCLWFLGHYEAARRAWRRAAAYRPTSAPPHLLLGLTLINAAKYPGPLPAGMYGAHTQRPEDEARRAAYADGLMHIQQAWQRDKTCAMAAVVLASHLTSQALHAWAPLWPAAHDMTTPAASIASSSSSANSLEAVSTALARALKLGEHAVQYADSRSIVMHAWLQYAYALHVATHLPQNASDHTVRVLALRYYGRVLEAQGRTQPMSTASSALAAAAGPMAAGTAGTTSASSDTSGYRHPLAHGIALASLGHAQLEASTGDVQGAMRTLDAVLLRPSGSAAYATELVLMAGLLLATPAAGSTAATDTTAQADRRRRARALLDRTIHTATEARALLSPKSLVGEGGAMASERLSSLTLTALARLGDDPRVRACLAFLWARSARERAISEYEAARAALPPSQEGSPLMYALELNMGALMTYTADAGMLRRGLVHLQRALQATTGSSSNDNNSDNDMVQAIKVLANYNMGLALENLGDATQARDAYAALLAAHPEYVAARVRMAVLAAQVPQDTMIPSDMPGGIERSARDVANTRFKEALSSDPGDLSVRAEYMRFLAGAYPANRHPAWAALKDSAAQLFLGADAGKAVFGSASVARRAADEARHDAYILGTLGWAYYQLGVHAMPGPNQRAERAKCMLRAADLFDKALAANPQNVFAAQGLAILVADDALGDPHAAPDVMEARRRTAAEDAAALLGKLREVRDDASVYVCQGHAFMLCGAWDRAAHVYELALTRYRCERDPAVLQYSARALYALGLQDRAMEHIQLAMAQLSTACDVLAERSGMAGGEADLAYASSSAAIEWKQVMYNRAVMSHKALQMLYDMPVEQRTSKDLSTAIQWVEQAQPVLQALVDAAKREQLLYITDEIVEQRVKYADMSLLKQASQQLQDTLAYEQAQRDKLAQLDEKQREREAHLAQLRREKEEEHRRKAEAIAESRRRAREEASQIEYDREPSPEPRKQRAAPRKKKTPAQTDDFVAQDDEHLFEESSDDDDDRNDPGDNDDDDDDNDNDNDGHDNDDDDEDVAAGDRKDMNVDANADAPSSHTSPRAADDMDQDDSDDGAATASAPNSMRARLEALARERKKRNEPDLQRPKKRASDKASRKESKKAKLDQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0B9</accession>
    <name>A8Q0B9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731011.1">
        <property type="nucleotide sequence ID" value="XM_001730959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0B9"/>
    <dbReference type="FunCoup" id="A8Q0B9">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0B9"/>
    <dbReference type="GeneID" id="5855318"/>
    <dbReference type="KEGG" id="mgl:MGL_2010"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2010"/>
    <dbReference type="InParanoid" id="A8Q0B9"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="41"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="8">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="328" mass="34883" checksum="2137626379F1A2BD" modified="2008-01-15" version="1">MSTENPKILPSSVSSEKTGSVPRSAMRNIKPEAGSGTLGTFGVKSGLAQMLKGGVIMDVVNAEQARIAEEAGACAVMALERVPADIRADGGVARMSDPAMIQEIIDAVTIPVMAKCRIGHFVEAQILQSINVDYIDESEVLTPADEEHHINKHNFKVPFVCGCRNLGEALRRISEGAAMIRTKGEAGTGNVVEAVRHQRTVQAEIRRAASMSDDELYSYAREIQAPFHLLKETARLKRLPVVNFAAGGVATPADAALMMQLGSDGVFVGSGIFKGANQAERAKAIVQAVTHYNDAAKLAEVSTNLGEAMVGINITDDMKGGKLASRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0E0</accession>
    <name>A8Q0E0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731020.1">
        <property type="nucleotide sequence ID" value="XM_001730968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0E0"/>
    <dbReference type="FunCoup" id="A8Q0E0">
        <property type="interactions" value="699"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0E0"/>
    <dbReference type="GeneID" id="5855327"/>
    <dbReference type="KEGG" id="mgl:MGL_2019"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2019"/>
    <dbReference type="InParanoid" id="A8Q0E0"/>
    <dbReference type="OMA" id="MYDEICK"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Nop" evidence="5">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="319" mass="33967" checksum="FDEC1C51F4FE64EA" modified="2008-01-15" version="1">MTLLAPNLSALVGTRVATKLIGVTGGLSSFSKIPSCNIHLLGASKTGTSGLSSIHGGSTRFSGYLAQCSLVAQTPEEYRMQALRMVSAKASLAARMDLNSSSAHTATGQYGASLSEEISRKIEKLMEPPPAKLIKALPVPSEGGRKQRRGGRRARKFREMHGLTEMRKMQNRVEFGKEEEEAGAFDETMGLGMIHTKASGKVRATMANASSKARMSKANKERLATLNRPTLSLQNSAPSLSSTSGTASSLSFTPVQGIELVDPSRQKKAEEANSKWFREGQFSLLPDAGKSTTTTTIPQKRGASGMPPPPPPPGRPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0M8</accession>
    <name>A8Q0M8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC45-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731057.1">
        <property type="nucleotide sequence ID" value="XM_001731005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0M8"/>
    <dbReference type="FunCoup" id="A8Q0M8">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0M8"/>
    <dbReference type="GeneID" id="5855364"/>
    <dbReference type="KEGG" id="mgl:MGL_2056"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2056"/>
    <dbReference type="InParanoid" id="A8Q0M8"/>
    <dbReference type="OMA" id="EDCFMEA"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="87909" checksum="52148092D724C6C9" modified="2008-01-15" version="1">MIVHWPRETGDDARLGVRESLDYAQAYKHICSMARRRVLGGSNDPDTGTPPAIGGATVLIVTTPHVDSLAATRILTQLLVHDEVPFRLVPVNGYRALRRILAQDVHEHHELHTLIFVNLGSLLSLPQMMPLPPHCTLHVIDSHRPWNLTNLFATSRLNDQIWIWDDGEIAQRLGKEREAFEMLEFDYESDSESESGLEQELEPELEFDSEAESRPDSRGHHPDTNPEPSTSEDHTILMEASRKRSHSPSRKERSSKRTRLDASQRQIYRAILAKYYARGSSIGMSTAQMMYMLAVSLGRSDRDSLWYAILGLTSQYTSNAIHATAYDGYAAALASDVVAMNAVSDQDTPSTLPGVNVHGADDSSIRVLPEELRFTLYRHWSLEMSMYHTSYVAAKLGIWREKGIHKLRGLLAKMGLSLANCRQTYEHMELDLRESLVQRMESIAPEYGLVDLTFRSFLRAYGFRSMPISACDAVEGIAALLQAAHGVRIEIDGVHIVRSESTVHGGTLPMDRAVSSYGGRTLWVLNDDEGLHIPALSRGNSQTPGYLDSSTSGLQPIHANEPQAMAHAPSSSFAYENKEIDSDTSAVWVKNFFEAYRAMDAYRPQNVALLQASLQLAKSLHQAIVAQGVSIIVKQSIKTLRSFRLTILQEGPSLHLFVQPDTLTRLGYWLIDALRDIVSEQHAKRMEARRERRRSKGSSGDDTLDSLSSALTTLPFVLAALDASRDVFVVVGIVGAAEYGDVAKNQFGLAFQDAAELSGARMRNDLFESSVLEVRRADLMPFVEALHLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0R3</accession>
    <name>A8Q0R3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731071.1">
        <property type="nucleotide sequence ID" value="XM_001731019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0R3"/>
    <dbReference type="STRING" id="425265.A8Q0R3"/>
    <dbReference type="GeneID" id="5855378"/>
    <dbReference type="KEGG" id="mgl:MGL_2070"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2070"/>
    <dbReference type="InParanoid" id="A8Q0R3"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15054" checksum="83F09D91853AF613" modified="2008-01-15" version="1">MPRLSIACVAVFTAGVVFRIFASWMSSWGELLVDRVELATVMDRLDLLRELQTLRHSVRANPRDVWASLSVHHSPLLLLLPQAWLMDPVRSATLWILLDVVTAACLARIASVLRSRIKDKSILSVSLTPTLVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q173</accession>
    <name>A8Q173_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TFIIS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730746.1">
        <property type="nucleotide sequence ID" value="XM_001730694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q173"/>
    <dbReference type="STRING" id="425265.A8Q173"/>
    <dbReference type="GeneID" id="5855053"/>
    <dbReference type="KEGG" id="mgl:MGL_1745"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1745"/>
    <dbReference type="InParanoid" id="A8Q173"/>
    <dbReference type="OMA" id="CTECAHQ"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="68" mass="7693" checksum="4FF32E54E445BD1E" modified="2008-01-15" version="1">MYLERKQVDDVMGGEDSWKNVDSTDATCPKCDNGRAYFMQLQIRSADEPSTFLIRFGFGANMGSDYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1K0</accession>
    <name>A8Q1K0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730801.1">
        <property type="nucleotide sequence ID" value="XM_001730749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1K0"/>
    <dbReference type="FunCoup" id="A8Q1K0">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1K0"/>
    <dbReference type="GeneID" id="5855108"/>
    <dbReference type="KEGG" id="mgl:MGL_1800"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1800"/>
    <dbReference type="InParanoid" id="A8Q1K0"/>
    <dbReference type="OMA" id="KPDQKEY"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8599" checksum="FD16AEE017ADBC61" modified="2008-01-15" version="1">MSERIRELAQEPVAFLNEGTQFLNRCTKPGRKEFIQICRAVGTGFVIMGFIGYLVKLIHIPINNIVRAHNNTQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1K7</accession>
    <name>A8Q1K7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730804.1">
        <property type="nucleotide sequence ID" value="XM_001730752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1K7"/>
    <dbReference type="FunCoup" id="A8Q1K7">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1K7"/>
    <dbReference type="GeneID" id="5855111"/>
    <dbReference type="KEGG" id="mgl:MGL_1803"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1803"/>
    <dbReference type="InParanoid" id="A8Q1K7"/>
    <dbReference type="OMA" id="FDMEPLQ"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="152" mass="16669" checksum="AD02D67ECDA8D5BD" modified="2008-01-15" version="1">MSFLRSSIASTLRAPLRSATAPRVAVRAISTSPLRFSEHQAPIIQGEGPKPGEIASDEQQSTGLERFELMGRLQGVDVFDMSPLDASRQGTVANPIKVRSMAKEQVIGSTGYPADSFDTVWMKLDFEHPRARCPLSGNVYELEYIGPEDHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q249</accession>
    <name>A8Q249_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730680.1">
        <property type="nucleotide sequence ID" value="XM_001730628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q249"/>
    <dbReference type="FunCoup" id="A8Q249">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q249"/>
    <dbReference type="GeneID" id="5854996"/>
    <dbReference type="KEGG" id="mgl:MGL_2134"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2134"/>
    <dbReference type="InParanoid" id="A8Q249"/>
    <dbReference type="OMA" id="WIPDTIG"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="425" mass="46425" checksum="6A713AB104B34F56" modified="2008-01-15" version="1">MDKSQDPDWMQPETAETSRSMSSTSSLGSTFSADDPADLSQEDPYPSRDLLASSADCLHVWEMERNEDVSDMYGAMSIRPSLSSKKHHEQQQQQPAAPRYVLREKCALAHAKSSVSPPAPLTSFSWNAPSPNLIVTSSIDTTCTIWDLPTRTALTQLIAHDREVYDVDWCPGSADVFASVGADGSVRVFDLRNLEHSTIIYETNAQSSMSHDRRRDSKGPGALYGGMGPSGMTVPLLRIAFNPWDANYLATFQLESNTVQILDVRAPGSSILELRGHSGPVNSVAWGPPSQGIPRNGPSKGMICTGGDDAQCLVYDLTSATLRTASAQGRRSRNSLYQRSQSPHDGWRVGAEVPVLAYTAPSMVNNVSWLGMSSASRRASHQSKHRSFYRNLLSEWTDYTSPSSRHGGTDWLALCAGQSVKVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q254</accession>
    <name>A8Q254_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitin synthase</fullName>
            <ecNumber evidence="3">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2139</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730685.1">
        <property type="nucleotide sequence ID" value="XM_001730633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q254"/>
    <dbReference type="STRING" id="425265.A8Q254"/>
    <dbReference type="GeneID" id="5854981"/>
    <dbReference type="KEGG" id="mgl:MGL_2139"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2139"/>
    <dbReference type="InParanoid" id="A8Q254"/>
    <dbReference type="OMA" id="GCMASDI"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="14">
        <location>
            <begin position="364"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="557"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="929" mass="103351" checksum="806085D1986AD600" modified="2008-01-15" version="1">MQRKKSLVRHERERIDPNHRQWFYRNHAAQMDQNRNSNLVYMPSSTGFLPQHGSAPSGSGMAGITGPGGGVSGYGVTGPNAPPPTQFARGTSLRRGKSLLGHNEDKVESGIHFLRRGVSMRRLPPGNPEPGAGGGGDKQPPPEAPPSGKFDWIAPGPVGPWMIYSWLITCCITSPCLKLVGIKTPEQQRAWREKMGLISIILVLMAIVGYITFGFTQTVCGVQNRYELKDVFTKTEMSSSVLLAGKMISLDSYPHPPFPGDDQFPNLTSTHNVFAYNDHYGASSGADLNLLFQKTGDECEGVLEPVPDSNPPRYFRCALLRRKSEYGSPMFIDDRACHPESVRSMVLNQQPNKHLPPVHGTAFVRWNDTGLQNYSNYLFYRSFVIDLSILEYSDTKLTPFLQQLKNNDTKKEWTGRDITAKAMRNNVTRDLDCLKQLGSIATLDVDSYGCIASQVELVLSMIFIVGLVAIKFLMAVYFAWCISWKIGNYDKESYVQRIKRNNEIEDWSEDIYRPAPPGYRPNVKKSFLPTTSRFNQMYQKPQAKPTTMERKIAAARLGTNSAVTSPPGSPMLGTGRSSASLAQPMLPSSQSTRSSNSSSDSPWGPCPFPLWNVVPQPPSSYQPFNFPLVHTICLVTAYSESIEGLRTTLDSLSTTNYPNSHKLILVIADGIVKGADSDISTPDICLSMMKDLITPPEEVEGHSYVAIADGAKRHNMAKVYAGFYDYDDQTVERSKQQRVPMILIAKCGTLMEMDSAKPGNRGKRDSQVVLMAFMQKVLFDERMTQFEYEFFNAIWRVTGVTPENYEIVLMVDADTKVFPDALTRMTAAMVEDPEIMGLCGETKIANKTQTWVTMIQVFEYYISHHQTKGFEACFGGVTCLPGCFIAYRLKAPKGPKGLYVPILANPDIRRALFGECGRHSAQEESAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q282</accession>
    <name>A8Q282_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730710.1">
        <property type="nucleotide sequence ID" value="XM_001730658.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q282"/>
    <dbReference type="GeneID" id="5855016"/>
    <dbReference type="KEGG" id="mgl:MGL_2164"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2164"/>
    <dbReference type="InParanoid" id="A8Q282"/>
    <dbReference type="OMA" id="NAQWTNA"/>
    <dbReference type="OrthoDB" id="3364898at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="EDP43496.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="Proteomes" id="UP000008837"/>
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    </evidence>
    <sequence length="3073" mass="325113" checksum="29F27CD5B80485F4" modified="2008-01-15" version="1">MALRALKIGRKKSEGHLSPTNSGTTAADSPKGQHAKSSGGSGKGLPDFSLTKNKSKSKSKLTSTAHYETTSSKGKMPVSSNAGESGSLHGSTSSSDLRKRFRMPSNLSLNSKRSFGFGRSASSADPSSSVARSSADKTVKSAISNPTPGTPPGVPSSSSVATSLSRQNSSVPGSPLSNESASIKDFIPQTPKGKSKAFETAPATQPVERSRFFAPEHLLRKKSSSATLRSTATSGNPGEIVTFASHRPPQRAISTPASPSQAPNNLSMLPGTSLSGLAPSISGAGLNLSLASYNSPSVKSSHPYLPSPSMSAGLGTPQSVPPVDRSNGVPASSNALSYLMSHSDSSRGEVSDLSSTTVIQRPSEDVSMPRSGTQQSLSDTASMYDDFQSVEGTYVSHPTSMMFDALEHFEAPADSAAPKGENAIDTTEPQNVSGVPERVPLGHLKESLLINSAGRAPEVQADEINEIPVIVQAAQESRDPFKPSDSTSFKLKKYTGQNTMGKATLSSKNREGLNAHSYVDEETNVEFKDATNMSEPEFTQTISPRISESSAYTDAPFQDSASQATQPLSASDQPGDGVVSKAETTTSKSDAQYRPEAESMFGFDNETRSIDDYTPCGSQRESSEYSLKTSTPTGTHGKVLSLSRYYPSNVSPSKGSKRAKQAPSPTANPSELLEEIMSDRTLNAGSSVASGNRPPVHLVDALPHLSTPSALFKPTEPLALKKSNQSIAPDSVSTKTDSPAQEPRKSVRTGKPVVLVDPVVPIDRDTGTPATEKSLLANMPVLPKIPRSMSQDQINLPEILPVPVEPSSASSFGSAKQFSSYQSVPLAPVARDVSLVEKPVTPLPVSAPPTPMKEQPLPNIPANHYGSFPLAPVARERIVNEFPDGADGITAAAPHAYDLGVKSAAPAPVGLPRSVSLPSFYHADASLPVPQPLEKNRPDAVESNDLNPLESVAEDRDELSEIPPEKPLKILGPLKGADWRVPLAKGSVQPPHALSESPKKDASLPAPISLTTPVSNHAPSSESVSHEEHPQESQMPLESKESEQMDADVSRDRCDPPLDPEDFVDEAQVDTMEPIPEASTETHGSTESEEAGPTRPVAEGSKSEGTLPYDETSPKHAKNEAYTVPVRRSQVSTDSTGPSDPVESSATGSRVTEPIEITKPTVPIGNGLAETNREDDPVEPSLPVDSHPNVPVKPEAVAQTKAEEHSMPEGQQATGPLSHAASVDAKVTHEPVYGKNSNLAEFLSEGSADPAQTPWEGSSDLTGPVKSLDLAPRNAVSENDTVGIAADDAETLQPSLDGSTELMQPTSQFAPSLDAPTTREDIPTHSAASVEPEPDMQPLDKKSHLSAGHIAPARDASELGGMMPSESSSCVLRPHSFPGQPEQGRVPVAGSLSEILQPPAAALVEPPNSGEPPTPESTDADTNQPMSPAEPTAVMETPSSSGQLVSKDTSDGPLGDIDSSAPVPATDSQDVQALPPTPKLPKAEDLSEGVASKSEDELCAPDFEAVDGHKPLPSVPLDGNDLPRSASPGNDQFALDVLKPDEPESASKADDSMPGDPGAFSSSVGSSRPLSPDMNSKRSTSVSPAEFDGDASAEPPSLESQEQKEASSAIESLSAVAGAAADAATGAAGAAADAATGAAGAAAGIAAGSMLAGFSAMRKPAFMDSLDEKEDTKATDELYETDTDMESTYSATQSTEPDHSHQIRPTKEPLETSASSFVGERDPAMEEFGPTPSHMMKESEEFNDDEQLSSEQEAQKTSEEPKHRNTFLQAASGLFSASAFAFARSSWGGDWSSRDSPKDESSPSDEPTITTIPQPEQTTSLESRLEPKPAAESDLLLKSDQQLASDKEDFPMEAQQDAVPKLDEQESDLSIKKRTDENVPEPSSESALHEPNVELEPESQLASQPPLAGAEHDAESKPQPETTLFKSPEEPLERGAGFGPDEAELPSQREAEQLPEITTAPEPRVKHESQPSILESQAGHDAGLQSDSAGISESADQPKLQPSVAKTPGEESVPHVSDAASVHEPGTSPVISGGHVEGEREPKPVSIPSDQISKSEQLPVLDDGIAHDSDVEHERKSETVSMEPPVKSNVTSAVHAEPEPELPQLPPKPEAVLMPDSNSSVHVATTPNFVPERGDSSVDAKSDRMSGIKHVLSSHETAATPAMAQELESVPAPEAPDTEKLALSSKESESVESARMTPMSSEPTIVSERETRAPLVSQPEVITVPYPKDMSSQKFERHTPLEVPTSHADADHHAPVKPIMAQTAASPELPHKPMFMGLYPQGTLPWAVGTVPLPHHAEVQSPHTQSRLSSSMADVDDALPPKPPVLEESPSSITNLRPEHTVQGMQQPVSSDPPAHPHDKGQDVRSTPKDLPTDPALPWHMPAQAKMASEPSHIAPLESSLALNHALGNQVSPVPVQESSLSTEHMPRQVATDNAQQREMGPALSTRMDTYERSSSPLVSAPKPVAASIPDNVVPPNVLEKQPSEAMPAMQGRSNLHDLADQEPSRRYSVESQYESEVHDGGFEPRFLDTVPEERAEMSTEEDMPRGGAHAEAPAISTRATPAKSGKQPTISTARTPLQGTGKYDPYQLKGFIRAMSADNYEHAMRRAFRMGVPLAEIPASSPESSTEPAESGKRPSELFAGKGVRWDSPDWLRSQLRKNIEAPSQAEFHAFLKSRRQIIPAFVWRDAAQELKLPKEKYVPLTPSPSAKTAARDSMSDRTSHTSQPSIFEDASTFEPLIPDVPPDLVSSEDTNAPKVPESHQARTEQEAPVTTKQTLEEAADIVPKKKPSATDLGVGSLMSMNSLLSDSDPIDTSLLSMDQLEKSYQGRVRSQAPKTPVVVPSIASNNPGLTQTSASTEPGPSSSSSSSALPGLPGLAPVVSPTSATIAPVLTSPGGPSPATTSPGYVPVPASTSVSALSSVYAPKHTQALSPMGSYAPTPYASLDAANHSATQDRGVKPVPAPTSVPLSESRASEFLPYADAMAAGTPQLQESEPDIPPMVPPKSDKPWKKHTKPSKLPSSSESSQQDSNMEAFSHRPTRDDVHSHVADRPYTSNEQTSMMHPEHQELGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2F7</accession>
    <name>A8Q2F7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_2190</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 13"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730395.1">
        <property type="nucleotide sequence ID" value="XM_001730343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2F7"/>
    <dbReference type="FunCoup" id="A8Q2F7">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2F7"/>
    <dbReference type="GeneID" id="5854714"/>
    <dbReference type="KEGG" id="mgl:MGL_2190"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2190"/>
    <dbReference type="InParanoid" id="A8Q2F7"/>
    <dbReference type="OMA" id="SFFDFDY"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000028">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="39"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP43181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="372" mass="42633" checksum="FA8E36727F23A215" modified="2008-01-15" version="1">MNSSDTNVPHNTLPSFQPQAPMRNMNKDPADIPLLGGSYKLVKTIGEGAYGVVYSAIHVPTSTRVAVKRISPFDHQMFCLRTLREIRLLRHFHHENIISILDILPPGSLETFTEVYLVQELMETDMHRVIRTQDLSNDHFQYFVYQILRGLKALHSAGVLHRDLKPSNLLLNANCDLKICDFGLARSAEQPEPESKAFLTEYVATRWYRAPEIMLSFKEYTKAIDQWSVGCIFAEMLTGRPLFPGRDYHHQLSLILGVLGTPSLEDFYSITSARSREYIRSFPYCERANFAELFPRAEPLALDLLDKLLTFSPQKRLTVEEALSHPYLEPYHDPSDEPGAEPLDPSFFDADFSKEPLSRAQLKELIYREITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2M0</accession>
    <name>A8Q2M0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730413.1">
        <property type="nucleotide sequence ID" value="XM_001730361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2M0"/>
    <dbReference type="STRING" id="425265.A8Q2M0"/>
    <dbReference type="GeneID" id="5854720"/>
    <dbReference type="KEGG" id="mgl:MGL_2209"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2209"/>
    <dbReference type="InParanoid" id="A8Q2M0"/>
    <dbReference type="OMA" id="CYQQPLL"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="207" mass="23122" checksum="85251EC5BC945D0F" modified="2008-01-15" version="1">MCKALHAQLEKFKRADFGRCPRVLCYQQPLLPLGPSDFPFQSPVRLYCPRCEDLYRPKSSRHGAIDGAFFGSSFPHMLLMVYPHMIPTKVTVVPPPIPFAQKQYGGVSADVLHQRAVALERRTGNATSAGEETDTSVMANDASSEMRAPTDVVFERVVPRIFGYPVHETSQLMAWQDRQQKKQAALIADFRQQKSASAPPSCKDQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2V1</accession>
    <name>A8Q2V1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730445.1">
        <property type="nucleotide sequence ID" value="XM_001730393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2V1"/>
    <dbReference type="FunCoup" id="A8Q2V1">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2V1"/>
    <dbReference type="GeneID" id="5854752"/>
    <dbReference type="KEGG" id="mgl:MGL_2241"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2241"/>
    <dbReference type="InParanoid" id="A8Q2V1"/>
    <dbReference type="OMA" id="GCQSGSF"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="39"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="353" mass="38987" checksum="7F7CFB7C8E439D83" modified="2008-01-15" version="1">MSTAESQPWVERYRPKSIDEVASQQHAVNVLRKALTSANLPHMLFYGPPGTGKTSTILALARQLYGPELMRSRVLELNASDERGISVVRDKIKSFARAAVSAPNPDYPSPPYKIVILDEADSMTQDAQGALRRIMEQYSRITRFCLVCNYVTRIIEPVASRCSKFRFRPLDVASTEARLLHIAQMEGLRLNPDLVPVLIRSSEGDMRRSITYLQSIARLASARGGDVRDMSPTTVSELAGAVPTYVIQSLVRAIGIDSDDINDELPPRATGSTDFDVIERAVRHVVREGYSSLQVVLQLHDYIISHPLLSAKRKTKCALHLGATDKSLMDGGEESLQLLALCLALHEDVIGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q328</accession>
    <name>A8Q328_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730502.1">
        <property type="nucleotide sequence ID" value="XM_001730450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q328"/>
    <dbReference type="FunCoup" id="A8Q328">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q328"/>
    <dbReference type="GeneID" id="5854809"/>
    <dbReference type="KEGG" id="mgl:MGL_2298"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2298"/>
    <dbReference type="InParanoid" id="A8Q328"/>
    <dbReference type="OMA" id="TTVWKHE"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="15"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="142"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="292"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="42808" checksum="68EEC40D3B45AF12" modified="2008-01-15" version="1">MGAEASAGVESYFATPAVDHAVAGVAAGTISTLCMNPLDLIKTRFQVNQTAFSHVPAERSVFYQSVARRRWLFWLMGGKPVVDIADGIYGIYRHHGFRGLYRGVVPNVVGNASSWGLYFLWYTMFKDLMVRNSGEGSEPVRLSPMSHLLAATESGVITAIMTNPIWVVKTRMFTTTVTEPQLQPGVSGSYGPVGDPSRAGLAHILREPGAKPPKAYRGLLHGLVSTVQSEGIAGLYKGVGLAIVGVSNGAIQFMTYEQLKQWRSSMKLRHSVDGSRSYSELELDSVKLSNTDYTILSGAAKLLAITLTYPYQVVRSRVQNHATLHIYPSAWACIRRTFRDEGFFAFYRGFATNAVRILPGTCVTFVAYENVAWMLRKAADARSSSALEVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q342</accession>
    <name>A8Q342_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2306</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730510.1">
        <property type="nucleotide sequence ID" value="XM_001730458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q342"/>
    <dbReference type="FunCoup" id="A8Q342">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q342"/>
    <dbReference type="GeneID" id="5854817"/>
    <dbReference type="KEGG" id="mgl:MGL_2306"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2306"/>
    <dbReference type="InParanoid" id="A8Q342"/>
    <dbReference type="OMA" id="RAILHAH"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="86"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="615"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="630"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="687" mass="77451" checksum="61A4873900C98775" modified="2008-01-15" version="1">MTQVRRFQPVSARLVCLYLILTSAAAVQGWLDQRGHKVGVVKHMMKSSPVYTLMRGAILVCGWAVVVYLFRRVLEAAKNSELNLYDPFAILGIAASATEREIRRRYRRLSLEFHPDKVGSVSNKTKEQIESHYIEITKAYKALTDEVTRKNYEEYGHPDGRQEMSMGIALPTWIVDSKHNVPVLLMYGLVFGVGLPLLVARWWYGTRSRTKDGVLNATALSFFLKLKPDVSANGILLMMAQSEELSRDLVGRLSASDMPAYEQLEKKTIDAYRELRGSDLVPEHVPVNVRRALVLFTAYMYRIESGNLHIETIKYDIGYYAEKLLRSLMAMSTAHSRLNQTNVIRDMLAHVVQAVPLDGGRVSELLQLPHMTLHLAKKLCSIEPVAKLGLQGLWKVPEAERHALLVGDKDGMSEEQYRTCIRAVGEWPRIELVDAYYTVIGEERVSAGSLMHLVLKLRLLSMKRDGSILRNGRRLDARDKHDDNVRSGLTETETISEANAGREPMGYVHAPYFKEERSPGWFMQMGDPKSDHLIMSPTRFGELGVSQLRVVTAPIVAPPEPGIYTFQVEINSDSYLGSKAVKVMKLNVSEAVAPNEDEEDEISDPEEDTIAGQMALMRGERVKRSNVVYQEDDDDDDDDEEEEDDNDDDDDDSDEDEDDDNDDDDSDRDGKKKGRATLSKDSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3D0</accession>
    <name>A8Q3D0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730567.1">
        <property type="nucleotide sequence ID" value="XM_001730515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3D0"/>
    <dbReference type="STRING" id="425265.A8Q3D0"/>
    <dbReference type="GeneID" id="5854874"/>
    <dbReference type="KEGG" id="mgl:MGL_2363"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2363"/>
    <dbReference type="InParanoid" id="A8Q3D0"/>
    <dbReference type="OMA" id="QDCFWES"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="254" mass="28413" checksum="476502BA12B7E4C1" modified="2008-01-15" version="1">MYFDYARTQTYARGLLQCANMHPNFPIADHQGTQALDIFVLPEFASLQSVQETLSRSTTHWWIGAQNVCEYERGAYTGEVAASTLAQVGCRLVELGHAERRHLFNETDEIVARKAFQCVRYGLIPLVCVGERTCTSDTLLAVDECWHQVAPVLVNVPHDAPICLAYEPVWAIGKEEPATPEHIRAVTQALRSRCLAEFPERHDVSLRIIYGGSAKLGLYSKISDAVDGLFLGRYGHDPATFIDTVWEVYKADNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3I0</accession>
    <name>A8Q3I0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2408</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730612.1">
        <property type="nucleotide sequence ID" value="XM_001730560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3I0"/>
    <dbReference type="STRING" id="425265.A8Q3I0"/>
    <dbReference type="GeneID" id="5854919"/>
    <dbReference type="KEGG" id="mgl:MGL_2408"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2408"/>
    <dbReference type="InParanoid" id="A8Q3I0"/>
    <dbReference type="OMA" id="CTGKVEQ"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="35"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="110"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="428" mass="47256" checksum="964EF88E1C6A8A64" modified="2008-01-15" version="1">MSDLEKVPMDGSSSFEALRGDASASKEDNHVPNTRTVQLHVSGMTCGSCVASIEKMLGQKPGIESVTVALLAERATVVYDAASTWTPDKLVEAIDDIGFDAQVVPERAEDAVTLSVFGMTCSSCTSSLEHALMRVDGVVSCNVSLTLQRAQIEFDHHRTSVRALVEAVEDAGFDAIVFDDRDEAQIESLTHVHEMHDWLHAFMISLLFAVPEFLVCMVLMHVRLLRPFLIMQPVRGLYMQDVLGLLLTLPVQFGVGQRFFRAAYKAIRHGSMTMDTLVVIGTMASWTFSVLAMLMMLGCTDHCEKPRTFFDTSTMLITFVSLGRYLESSAKGQTGQALTRLIQLAPQKATIYTDEHHQTERVIPAELLQVGDTVKLVPGEKIAADGIVRHGQSFVDESMVTGEHVPVHKTVGAQVLGRHRQWQWNARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3M2</accession>
    <name>A8Q3M2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730650.1">
        <property type="nucleotide sequence ID" value="XM_001730598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3M2"/>
    <dbReference type="FunCoup" id="A8Q3M2">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3M2"/>
    <dbReference type="GeneID" id="5854957"/>
    <dbReference type="KEGG" id="mgl:MGL_2446"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2446"/>
    <dbReference type="InParanoid" id="A8Q3M2"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="216" mass="23656" checksum="1AF39A4D75A4223F" modified="2008-01-15" version="1">MSFRAFLSQTRASFAALTAPMIGARSSIMPSPPSAVPGQIRCASNLGPRRTKYRKAQKGRVPFPTGGSVKGTTVTQGVYGLRALDPSRITATQLTAAETALKRKLKVVRGSQVFMRVFPDIPFCVKGNETRMGKGKGSFEYWACRVPVGRVIFEIGGHVEIRPEVAKDEFITSSTPPRLGREVSHELHHVKPAGMPRLSHELDPQLVQKKATDMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4L8</accession>
    <name>A8Q4L8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730187.1">
        <property type="nucleotide sequence ID" value="XM_001730135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4L8"/>
    <dbReference type="FunCoup" id="A8Q4L8">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4L8"/>
    <dbReference type="GeneID" id="5854494"/>
    <dbReference type="KEGG" id="mgl:MGL_2569"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2569"/>
    <dbReference type="InParanoid" id="A8Q4L8"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="8">
        <location>
            <begin position="619"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="825"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="825"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1020" mass="112662" checksum="5D988E73B0BA09B9" modified="2008-01-15" version="1">MSMPLSMPPTTADIHRHHRHRTRPTTPPTPPTPPTPPTPPTPPTPPTPPTPPTLPTPSTPPLATTFRFLPARYTAWKESTRAFKAMRHNRSAQTTLPPVCVSPVPSVVAFEPLDAMIPITMRQGERMLKVTQNKVAMRLFRVDTESASIVWESKRGNSVRLYAVRDVRVGESARSYRHSLQISDEHEPRWISIIYQTARAYKAVHMVALSDESLARWRDSLLRILAQWHALVSGRVTASRAQGEWLQASWDVEKRLDQSALARLCQRMGVQISRPELDTLFLEADRERVGALNFEAFQRFVAALKRRPDVEQLFYQLAKRDAQESCSISLSSFTSFLHREQGEWKWTSDDIAHIYQRYRVDTLDGFAAFLMSRDNGAYNDPVLSGGEAAGKEKESGSLHARTQASSGRLDEPLSSYYISSSHNTYLEGGQWKGDSTVEGYVRALHKGARCVELDCWDGPGGQPQVTHGHTLTSRVPLDDVVAAVAQYAFVASPYPLILSLEVHNDLAQQVVLANILQARLGDMLVTAPLDDDVQPGMLPSPEQLRFRILVKCKDHVWIHSQVSQDADDQQPLPQGRSSSSTEQTEWESDSFLDQARNLVRLARHRTERGKIARPLARELVRLLVYTVGVPFRGLNKKEQYAAEHMFSLSERSAARLMRQSHADLVKHNLTHLTRVYPSMTKLSRLTSSANFLPMDMWASGCQLVALNWQTHDQGMSQNLALFARSAGYVRKPSALRVRSCLKNDGGTLLVSCVLTIVSAQQVPHMRSADEAVCPYATVSADVPQQWGKDAVQVSVPAAVPRESPSMATCQGDSLAGCTASGLAASGAGSRTRSTGSGSGSTTRAASLGSTPSPSTSLLPSSSSSSASSTGVANLLPPISSSAPVSSRRSPFRTPAVRSNGLNPVWQTSFLLDIRMPAGHDAKAIVLQRAQRLKHGKERTDDPCVWEDVTRGLLHLCFVQVQICDEQTSSQVPLATTTLSLGRLRHGYRHVPLYDMQLSPLMYSSLFVHTSYTHMEVLPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4M1</accession>
    <name>A8Q4M1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730190.1">
        <property type="nucleotide sequence ID" value="XM_001730138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4M1"/>
    <dbReference type="FunCoup" id="A8Q4M1">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4M1"/>
    <dbReference type="GeneID" id="5854497"/>
    <dbReference type="KEGG" id="mgl:MGL_2572"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2572"/>
    <dbReference type="InParanoid" id="A8Q4M1"/>
    <dbReference type="OMA" id="TRFNKTH"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="204" mass="23274" checksum="E1B475E688658A7B" modified="2008-01-15" version="1">MSLMQSTPFIVDGKGHLLGRLASIVAKQILLGQKVVVVRSDLINVSGSFFRNKLKYLEFMHKRHLVNPCKNGPFHHRAPSRIFFRAVRGMVPHKTARGAAALQRLKVYEGMPPPYDRKKKFVVPDALRVLRLKPGRKYATLKRISSEVGWKYQETVDKLEAKRVVKQQAFHERKMANIKRRAAAATAAASELEPINKQLEQYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4N2</accession>
    <name>A8Q4N2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2583</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730201.1">
        <property type="nucleotide sequence ID" value="XM_001730149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4N2"/>
    <dbReference type="FunCoup" id="A8Q4N2">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4N2"/>
    <dbReference type="MEROPS" id="M67.A13"/>
    <dbReference type="GeneID" id="5854508"/>
    <dbReference type="KEGG" id="mgl:MGL_2583"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2583"/>
    <dbReference type="InParanoid" id="A8Q4N2"/>
    <dbReference type="OMA" id="AHASEYY"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000203">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0736">Signalosome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="14">
        <location>
            <begin position="56"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="369" mass="41674" checksum="89E9701EC9598F0A" modified="2008-01-15" version="1">MDDAAKEAQHVFENKHSVLQGEVHGDAALYTHDTTAYQALLRAAPWRRDRQYFRRVRVSVIALLKMLLHARSGGELEVMGLMQGHVRGDTVYVIDVFALPVHGTETRVNAQNEAYEYMVMHLEASQRVHRLENAIGWYHSHPGYGCWLSGIDVQTQQTNQQQDPFIAVVIDPLRTMSSGHIDLGAFRTWPQDQEADDTQPMRQHIPASKMAEYGAHASKYYALDVQYFKNAADRPLYDQLWHKYWAQALCVGTSTSMSMPAHTQQAEPSRQPQIPPSLELQRIHELREQMQDTVASIRSTNLLPGGVSYAQTARTVPRSADVDLHALAQQLEKRANEQPLGRVAHQAAAMASSAHHALEQERRRAMLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q563</accession>
    <name>A8Q563_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2733</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730351.1">
        <property type="nucleotide sequence ID" value="XM_001730299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q563"/>
    <dbReference type="STRING" id="425265.A8Q563"/>
    <dbReference type="GeneID" id="5854656"/>
    <dbReference type="KEGG" id="mgl:MGL_2733"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2733"/>
    <dbReference type="InParanoid" id="A8Q563"/>
    <dbReference type="OMA" id="HDANSKR"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="198" mass="22081" checksum="90743DE9C03C11C1" modified="2008-01-15" version="1">MRIEAQGSSLASYDRRWLEHFYLVACGYSPSKVVPIASKRAEHASPEFTRVTGLSNWPAIQVLFPTQSYVEHVSVEGSMGGGCFFGKPEEFRKRGLRCLYAQPVSSRGHLLMHAKSLLVTNHDNSCGYVYLGSHNFTRAAWGTISGTQAQPTQSLSNWELGIVLPLTEYDAWDAIPYNRHIEPYGADDIPWDASNLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q686</accession>
    <name>A8Q686_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729896.1">
        <property type="nucleotide sequence ID" value="XM_001729844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q686"/>
    <dbReference type="STRING" id="425265.A8Q686"/>
    <dbReference type="GeneID" id="5854203"/>
    <dbReference type="KEGG" id="mgl:MGL_2882"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2882"/>
    <dbReference type="InParanoid" id="A8Q686"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="55" mass="6403" checksum="C216B79F52960503" modified="2008-01-15" version="1">MALFSAQSYMLAREYSAHVKDRQVLSGEMLREYDEKFVMPRAMPLVRDASTMTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6C7</accession>
    <name>A8Q6C7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease</fullName>
            <ecNumber evidence="10">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2923</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729937.1">
        <property type="nucleotide sequence ID" value="XM_001729885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6C7"/>
    <dbReference type="FunCoup" id="A8Q6C7">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6C7"/>
    <dbReference type="GeneID" id="5854244"/>
    <dbReference type="KEGG" id="mgl:MGL_2923"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2923"/>
    <dbReference type="InParanoid" id="A8Q6C7"/>
    <dbReference type="OMA" id="YVMPNQV"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000008">
        <property type="entry name" value="Probable NUC1-dna/rna non-specific nuclease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="13">
        <location>
            <begin position="84"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="12">
        <location>
            <begin position="85"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="346" mass="36951" checksum="1245E3F95F42CA4D" modified="2008-01-15" version="1">MSLAAHVGLFAGGVLLGAGGATIWARRSPASSPQASPVVSTTSPTPTVKAPSSSPAAVVPPSAASVSDALLLSGHPGPVADFFQQQAYVTAYDRRMRHPSWTAEHLTAESIRRPPGTDANRSQSIFAEDVRLPAMFRATNKDYFRSGYDRGHMVPAADAKSSQDAMNETFLLTNIAPQVGPGMNRDYWAHTEDFVRRLTSQFKDLYVFTVPLYLPRQSMDGKWRVSYEVIGTPPNVSVPTHFAKVILGSGHMSGMPGGLGMGLGTTHNSALALGAFIMPNSMIPDSAPLRSFEVDVDAVERAAGLTLFPAAIKKSAKKLCDTVKCEIVVRDFSDAAKALPKPARTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6L7</accession>
    <name>A8Q6L7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopropylmalate dehydrogenase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730017.1">
        <property type="nucleotide sequence ID" value="XM_001729965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6L7"/>
    <dbReference type="FunCoup" id="A8Q6L7">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6L7"/>
    <dbReference type="GeneID" id="5854324"/>
    <dbReference type="KEGG" id="mgl:MGL_3003"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3003"/>
    <dbReference type="InParanoid" id="A8Q6L7"/>
    <dbReference type="OMA" id="DSFVMGE"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="3">
        <location>
            <begin position="14"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="373" mass="39903" checksum="AB3C9AA440E0950A" modified="2008-01-15" version="1">MLRPSTILMQRAMRIGMIPADGIGREVLPVAQRVMTAAPGAPQFEFVPLQAGFEHFQTTGEALPQVTIDTLKNECDAAMFGSVSSPSHKVEGYSSPIVRLRKELGLYANIRPVSGPILPGSPIQSPVDIVTIRENTECLYIKQETLEETPNGKVARAIRQITESASTRIGKKAMEVALSRKTMRAKAGSQDPTKVTICHKSNVLSVTDGLFRTSVRAVYESDKKENGGQGRYEGILLDEQLVDSMVYRMFREPNVFDVVVAPNLYGDIISDGAAALVGSLGLVSSVNAGDSFIMGEPVHGSAPDICGKNVANPIAAVRSAALMLEYMGYTEPALAIYRAVDAVLTQGKVLTPDLPGGKATTSEVEGAILRALA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-07-24" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7G1</accession>
    <name>SEAP2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable inactive secreted aspartyl protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2024" name="Biochimie" volume="216" first="181" last="193">
            <title>A Malassezia pseudoprotease dominates the secreted hydrolase landscape and is a potential allergen on skin.</title>
            <authorList>
                <person name="Chua W."/>
                <person name="Marsh C.O."/>
                <person name="Poh S.E."/>
                <person name="Koh W.L."/>
                <person name="Lee M.L.Y."/>
                <person name="Koh L.F."/>
                <person name="Tang X.E."/>
                <person name="See P."/>
                <person name="Ser Z."/>
                <person name="Wang S.M."/>
                <person name="Sobota R.M."/>
                <person name="Dawson T.L. Jr."/>
                <person name="Yew Y.W."/>
                <person name="Thng S."/>
                <person name="O'Donoghue A.J."/>
                <person name="Oon H.H."/>
                <person name="Common J.E."/>
                <person name="Li H."/>
            </authorList>
            <dbReference type="PubMed" id="37748748"/>
            <dbReference type="DOI" id="10.1016/j.biochi.2023.09.023"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>MUTAGENESIS OF TYR-107 AND 137-PHE-LEU-138</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Probable inactive secreted aspartyl protease (PubMed:37748748). May promote an inflammatory immune response in the host when the host skin barrier is breached (PubMed:37748748). Has no detectable protease activity in vitro on fluorogenic substrates, a peptide library, or with the general protease substrate casein (PubMed:37748748). The presence of the enzyme also does not affect the activity of the secreted aspartyl protease SAP1 (PubMed:37748748).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expressed on human skin of healthy people and patients afflicted by atopic dermatitis or seborrheic dermatitis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Although the two active site Asp residues are conserved, appears to lack catalytic activity in vitro. This could be due to the active site motif diverging from the canonical Asp-X-Gly-X motif (where X is Thr or Ser) to containing a Tyr residue (Asp-Ser-Gly-Tyr). Additionally, a Tyr residue positioned close to the catalytic site that is potentially involved in coordinating water molecules for nucleophilic attack is substituted to Phe (Phe-137) in this protein. Also, a Gly residue typically conserved at the tip of the protease flap to enable substrate binding is substituted to leucine (Leu-138).</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729787.1">
        <property type="nucleotide sequence ID" value="XM_001729735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7G1"/>
    <dbReference type="SMR" id="A8Q7G1"/>
    <dbReference type="GeneID" id="5854093"/>
    <dbReference type="KEGG" id="mgl:MGL_3331"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3331"/>
    <dbReference type="InParanoid" id="A8Q7G1"/>
    <dbReference type="OMA" id="NEMQIAR"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000460581" description="Removed in mature form" evidence="4">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727244" description="Probable inactive secreted aspartyl protease" evidence="1">
        <location>
            <begin position="70"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="86"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Does not enable protease activity; when associated with 137-Y-G-138." evidence="4">
        <original>Y</original>
        <variation>S</variation>
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Does not enable protease activity; when associated with S-107." evidence="4">
        <original>FL</original>
        <variation>YG</variation>
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="37748748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="37748748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="390" mass="41672" checksum="F7CF39315F24E4BA" modified="2008-01-15" version="1" precursor="true">MQLTIKALVGILTTISAATAVSFDMENLGAEKRGVSGEELHMLHGNEVLARFANGVYPEVANGTRVSKRAGGAEVDLTSVGGGTAWAVKAKIGSNEEEVTMLLDSGYEHALVAADSDYSPGKSSSNENTGEKFFAGFLTGGGNEGTIHLDDLSVGGLKASKFAFGYTKNRDFSSNQKLGGILGMSLPGHVDYVPGFKNHGWGGFIQTLKNQGVIDEAMYQMTLKGDGGKLSIGEVDDSQYEGDLETLMNTGKAYGHCGFKGTLNGEKHNFLLDSGTTGIAGSYDSVKKFLQGMSGVELVEEDKRGSVTGKVDCDSMPSFKISVDGKFDVKLSDDVMKKYDLGNGKCLLPIYGYTNMPKSYSYNWIVGGAFMREVSVVCKFDSNEMQIARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7T0</accession>
    <name>A8Q7T0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729566.1">
        <property type="nucleotide sequence ID" value="XM_001729514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7T0"/>
    <dbReference type="FunCoup" id="A8Q7T0">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7T0"/>
    <dbReference type="GeneID" id="5853872"/>
    <dbReference type="KEGG" id="mgl:MGL_3110"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3110"/>
    <dbReference type="InParanoid" id="A8Q7T0"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="57"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="201" mass="21526" checksum="9249AEFFA27D96D5" modified="2008-01-15" version="1">MLPTISPSGDLVLHARLPFLRVLSMMPFATSELKSRYPEVPPDLPAKKLDPSAGLGLRLGDMVVAISPSDPSRTVCKRILGMPGDTVLVDPREGVLSDAAELLAAHFEAGAGAALPLLRMQSSRTVTVPPGHVWLTGDNLANSTDSRNYGPVPMALIKGRVIARCYPRPQWFAPALKKVRPAMDLAADQRAAAGTMEHYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q843</accession>
    <name>A8Q843_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729654.1">
        <property type="nucleotide sequence ID" value="XM_001729602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q843"/>
    <dbReference type="FunCoup" id="A8Q843">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q843"/>
    <dbReference type="GeneID" id="5853960"/>
    <dbReference type="KEGG" id="mgl:MGL_3198"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3198"/>
    <dbReference type="InParanoid" id="A8Q843"/>
    <dbReference type="OMA" id="YKLDFMP"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="169"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="337"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="545"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="835" mass="92981" checksum="492361F4263B5937" modified="2008-01-15" version="1">MSRRDRDAPPHADASSLSTPSNTSQRRSVAALGSSLPLASTRRATPGQASAPGSSSIVRRTHSAQGPLGSYRSLSRSRTTPVREESLLGKRSFSSTHLQDSEFSTPQTSLAKRPLVSSALATAPRATDGSTGSAEPWNTPLARHRSGKSDNLLTSSPTLDHAYELQMLRTEYDRRIQTEQRAYQTLETQLRSQSRELDALKCQRVEVLREWETERALQQERQKDWEKAKANLEEQLTSLRTETLNLRSINEELRAQCQASASDARADVTSCQSQLVHLQAEYELARTENATLSHKNEALNARIEEIESAASPHRRAESDADDVALYKDQLSQHITAVHRLEAANMRLKAENTRLLEVSARVDVLHETNKGLESKLNRMDALQAALLKKDNELPSIHEEQQRWISVLSKGVATDEQAAFVAAAQASDQVPQLGVPDTLTPETLPAYISTLRGTIMGLTARIEGLKLSAEQLRTTNVELSRRAAQDSETEISLRRELEHTSELLLRTQRRADIESDDLHRCKAVLASFEQEAQQGHASYESTHQLRISGLEERITSLQAECESLRQKLRDTNTIKTEVPAPDTVSKETQHMLETWETQYRDLEKHAQSLESENETLWMRVGRGEYNVANERCLVLADNPVSRDLAVRTSALEALRKENQGLLNQVESLHKELAMAGTTAKLSELAPTDALVPLQTVENLRTELAQMQESLQLKDKGMLRLKQVFTAKANEFREAVQSLFGYKVRFMENGKVKLTSAYAGGARGTTLVFRSEEGNVGEMKLQGEANDGLANVSHLRDYWLSDGIRHSVPCFLAALNLELYENTTQAIRGSFGSADVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q850</accession>
    <name>A8Q850_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3203</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729659.1">
        <property type="nucleotide sequence ID" value="XM_001729607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q850"/>
    <dbReference type="FunCoup" id="A8Q850">
        <property type="interactions" value="595"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q850"/>
    <dbReference type="GeneID" id="5853965"/>
    <dbReference type="KEGG" id="mgl:MGL_3203"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3203"/>
    <dbReference type="InParanoid" id="A8Q850"/>
    <dbReference type="OMA" id="STMPKFE"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="166"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="369"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="521"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="560" mass="60521" checksum="EFB2AB3FD4F98B98" modified="2008-01-15" version="1">MPYGSYSGGNADGENGGYRSGYGGASRGGYGSGGGYGGGYGGGYGGGYGGSYGGGYGGGYGGGYGGGYGGGYGGGGDLGAGLSRINWNEADLVPFEKNFYKEDPRVTERSEQEVNEFRRAKEITLRGSNVPRPVTTFEETGYPDYIMREINKLGFTEPSAIQSQAWPLALSGRDLVAIAETGSGKTIGFALPSILHIKAQAPLQYGDGPIALILAPTRELAVQIQNECQRFGSACRVRTTSVYGGVPKGQQIRSLQRGAEIVIATPGRLIDMMEIGKTNLRRVTYLVMDEADRMLDMGFEPQIRKIVEQIRPDRQTLMFSATWPKEVQRMASDFLNDYVQVNIGSMELAANHNVKQVIEVCTEFDKRGRLIKHLEHISQENGKVIIFTGTKRAADDLTKFLRQDGWPGLAIHGDKQQDERDWVLREFKSGNSPIMVATAVASRGLDVKDISYVINSDFPTNTEDYIHQIGRTGRAGRKGVAITFFTSENSKSARDLVGILREANQEVPPELQDMVRYSGGGGGGFRGRGRGRGRGGGFGGRRFGGPRSSGANNIQVGSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8A5</accession>
    <name>A8Q8A5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="11" type="ORF">MGL_3235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729691.1">
        <property type="nucleotide sequence ID" value="XM_001729639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8A5"/>
    <dbReference type="FunCoup" id="A8Q8A5">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8A5"/>
    <dbReference type="GeneID" id="5853997"/>
    <dbReference type="KEGG" id="mgl:MGL_3235"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3235"/>
    <dbReference type="InParanoid" id="A8Q8A5"/>
    <dbReference type="OMA" id="HAMMVEL"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="86" mass="9773" checksum="74B91553B48E9114" modified="2008-01-15" version="1">MLPLTLLNAAHDGPILVELKNSETFNGHLVACDNYMNITMRDVFQTSSSGEQFWKMPEVYIKGSTVCTLFRAHECPRSSIVVWHMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8E0</accession>
    <name>A8Q8E0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729710.1">
        <property type="nucleotide sequence ID" value="XM_001729658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8E0"/>
    <dbReference type="STRING" id="425265.A8Q8E0"/>
    <dbReference type="GeneID" id="5854016"/>
    <dbReference type="KEGG" id="mgl:MGL_3254"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3254"/>
    <dbReference type="InParanoid" id="A8Q8E0"/>
    <dbReference type="OMA" id="YFILHAN"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="35971" checksum="D9F85BCCD260024D" modified="2008-01-15" version="1">MGTLPLAFHLSRQSLRKLELWGAGLLLGAALTVVIPEGISNVYRHQIPPRDATTSLISSKDLIAVCLLSGFLLMFIVDQQMIVHSITRGDSSAQLPVRDDVSESGATMRWQPNTGTPQVPFRSVIGGLLGVLVHAGADGVAMGSSVESSDVSLRVVVILAIMVHKAPASIGICTLLMARQLPKSQIRLAVLVFAVTTPIFAFLTYGILQALLSATGTKPGFIGTRDIGAILSFSGGTFLYVSIHAVMELASPAANLHALSNQRVHHPHDHDHPIHAHATEARRLSGTSPPLPSFLQEHPTDESERLLSHSAWSLVFVALGSVVPRLLQLVVGHDHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8F2</accession>
    <name>A8Q8F2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729716.1">
        <property type="nucleotide sequence ID" value="XM_001729664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8F2"/>
    <dbReference type="FunCoup" id="A8Q8F2">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8F2"/>
    <dbReference type="GeneID" id="5854022"/>
    <dbReference type="KEGG" id="mgl:MGL_3260"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3260"/>
    <dbReference type="InParanoid" id="A8Q8F2"/>
    <dbReference type="OMA" id="DSINMID"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="215" mass="24181" checksum="0CC20B92A922ADAD" modified="2008-01-15" version="1">MNYPMIPPASVGARKTFLARVLTDGSYLDPETKRLQEKALNRKPDEMPESPFNNEAMMENMMEQAKRSLLMMVPQTMIMGWVNFFFTGFVLIRLPFPLTQRFKVMLQRDIDTADLDVAWVSSLSWYFLNLYGLDAIYRLVMGNTRAADSMRDVAAFGGGAALLNNQQMPGQQVDHAKLHVAERESLKLIGAVNVKGVKWVGDGIEARVLGLYGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8G8</accession>
    <name>A8Q8G8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3268</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729724.1">
        <property type="nucleotide sequence ID" value="XM_001729672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8G8"/>
    <dbReference type="STRING" id="425265.A8Q8G8"/>
    <dbReference type="GeneID" id="5854030"/>
    <dbReference type="KEGG" id="mgl:MGL_3268"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3268"/>
    <dbReference type="InParanoid" id="A8Q8G8"/>
    <dbReference type="OMA" id="TISCANY"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="200" mass="23121" checksum="E58C62B64F1DA29A" modified="2008-01-15" version="1">MHATNTKTATSANEKDDDGAWFRDVRARVSEAFAWPPENEKHVLEPYAYLEQLPGKEFRSKLLDAFRVWLDVPENALEQIKGMVRRLHNASLMMDDVEDQSEIRRGAPSAHEVFGIAQTINTANYVYFQVLADMAQLEPRALPELIHELGWLHRGQGMELYWREHVECPSEEAYVDMVIHKTGGLFRHHTSARGMCFRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q911</accession>
    <name>A8Q911_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729352.1">
        <property type="nucleotide sequence ID" value="XM_001729300.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q911">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q911"/>
    <dbReference type="GeneID" id="5853659"/>
    <dbReference type="KEGG" id="mgl:MGL_3387"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3387"/>
    <dbReference type="InParanoid" id="A8Q911"/>
    <dbReference type="OMA" id="ELREWPD"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="109"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1601"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1133"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1702"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1133"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1757" mass="189623" checksum="A5B6C4D8B8EAD637" modified="2008-01-15" version="1">MTDPEHAPGPLTMENVKRLEREQEAAASEAWDANVNANANANVSSVTMDTADMLGEGPRHGALLQAEAEDWVLLESPYMTHWNNKRHNTNGIPRARRASDMPDWRMRERLRTVTAALVMCLNIGVDPPDVSKTNPCSKLICWMDPESLDASKALPAIGRNLQVQFETLSMKTRYKQYLDPIVEETKRFCTNLRRTAKDERVLFYYNGYGVPKPTPGGEIWVFNKAYTQYIPLTLYDLQTWLGQPCIYVWDTSAAGHIVANFRRLAEARAEDEIKAALAEGREPPPMPSPDGITIDATGEPQFPLRDSIHLAACGADEVLPMNPDLPADLFTCCLTSPIEISLRWFVLQNPLPSPLNVDMVMNIPGRLQDRRTPLGELNWTLTAVTDTIAWTVLPRALFRRFFRDDLMVAALLRNYLLAERIMRFYHCTPVSHPRLPPTHNHPLWDSWDLAVDQCLSQLPTLLAKEQARADAENLGIPMPPHLASFEYRHSTFFSEQLKAFEVWLSQGDVSRHPPRRRVQRHPVVRVNGSSMSDVSTSLSATSSLAAKAVASAAASATGTTTVAPSSAVPDLASSTSGLGVVSMHRRQSAGPGSMTGVASGTVEDSDSDTDSVADDPDAKATLSREHDPPSQLPIVLQVLLSQVHRLRALILLSQFLDLGPWAVNLALSIGIFPYVLKLLQSPAADLKPVLIYIWARILAVDHSCQVDLLRDNGYLYFAAVLSPFQPGQMPGHGVAAVPTTAVPSTAAPAVATDAHPMAHAHGGAAAGSVPNVGGAGAGQTLPIPNVSEHRAMCAFILAVFCQDFSLGQDACLETDVMDACLEHLEDDDYLLRQWSALCLAQLWDNNDVGKARAIAKDAHGKLCCLLSDASPEVRAAILYALGVLLGTSGGALCDASDGATSSDRRRERARGAGRPPCICTGALTGLTPARQRNMEVGIAMAILASGSDCSPLVRKELVIALSALVHHYHGFFVLAAYLCYMRDTAVYGEETPTQHAAAAPADMNADIEERLTQEERLLTGIVRGIIQHGESVETSDIANVPAFVTLFVALLDLSVDAHPEVANLASTVVDQIMAALVEHGALYADNSTMRQKSLEQLSQPHIMPTAAEPLSAAANHTSSLAGAAGALGATATKSRGSVSSLPSGMNTRASASASANASATDSRARPNAASHGVGVGAGVGSGAGYAAAPPAAATVGLPGYPSDRGFVDPSGDEPAGRGSTIARTIRAISSIAGTPAPSHAPAKVAPVLTSVAAPTRAAAASADGTPIATYKAPYGGGSQQPVCMTSQDSFSAGMPTARSRREVHIEDALAECIAADLHRLSVRGRDDTPPTTWLGRVQEQLPLKSRLFEWCSEYYTEPQMKSAEADEPGSSQYNRQMWRRQRCEQHMAEAMEQVGDAGSVRWSERVGMLTMPSAVQMLCFHEYDPHVVSVTDQDTLCVWDWQEQRLLSSFCNGHRPHGPVTSLAFINEEVDALLLTGAADGHVHIYRQYARGCGSKHGPELVSAFRVLPDLLRSRYPSGVRVTWQQVSGRLLAGGDSRLVRLWDAHRELCISDVPTHVNSCATSLTSDTDIGHLFMAGFGDGSIGVYDQRNPPTSSLVQLWEEHNAWVQTVHLQRHGARELVSASVDGQVRVWDIRARSSVLQCSAAWDHASTLSDMAVHDRIPVLAATSSPRPGGSSHIHTTQMYSLADLSPLGRPYQRPLQAPSLLSSGPARSLRDRFTPPSRYSPSTSIVAFHPHHPVLAFGGPDHLVEIFRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q928</accession>
    <name>A8Q928_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_3398</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729363.1">
        <property type="nucleotide sequence ID" value="XM_001729311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q928"/>
    <dbReference type="FunCoup" id="A8Q928">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q928"/>
    <dbReference type="GeneID" id="5853670"/>
    <dbReference type="KEGG" id="mgl:MGL_3398"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3398"/>
    <dbReference type="InParanoid" id="A8Q928"/>
    <dbReference type="OMA" id="LPHFNAR"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP42149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="480" mass="53371" checksum="946007AC7D8F29C2" modified="2008-01-15" version="1">MAFPALVISLVLSVIAYFVAYMSIKYSKDAFAQQGLNGIDLLKRDLWPKEVIPPIVPETQGLPCAAVYLLVLVVFIPFRYFGSSMYGLPKLLVGHAHSAPGLHQDLASFLSALLSIYSGTLLGFVDDVLDIRWRYKLPIPLLSSIPMLVVYMAGGGSTSIIVPAWPPAFRTVLGQNPLELGMGYYAYMMLLATFCTNCINILAGINGVEVGQALVIACSICINDLLYLNLPAVIRTAVMNKTYLPQHDSLLLGYHGSKDLVVRHLFSLHMLLPFIGTSLALFMWNRYPARVFVGDTYCYFAGMVLVSCGVLGHYSKTLLLFFLPQIFNFLLSCLQLFGVVPCPRHRVPFVDPDTRMLFPSCVRLHEETNAYVHCVLAILETCRFVQRIRDDNGHIVGVTNLTMLNALLVLRGSRVAPATVADIQASLANQDPTLRPAPIRTTLHVTEHLLWYHVMAVQIVGSMIAFTMRYWFAYIIFPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q930</accession>
    <name>A8Q930_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729364.1">
        <property type="nucleotide sequence ID" value="XM_001729312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q930"/>
    <dbReference type="STRING" id="425265.A8Q930"/>
    <dbReference type="GeneID" id="5853671"/>
    <dbReference type="KEGG" id="mgl:MGL_3399"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3399"/>
    <dbReference type="InParanoid" id="A8Q930"/>
    <dbReference type="OMA" id="SKSTITW"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="589" mass="63218" checksum="6D406D518177249C" modified="2008-01-15" version="1">MEERARVFAWADLATALCRYSWVVTTSTAMSRHLNPNIEAAKSQADAARSQGMECVNLALNIQSHVRLWILLGNLNFTHNVSMAQHAYIVAIEANRKSPVPWSNLGFLYLSVREDALAEEAFARAKTLAPDWPGSWLGSALIHRLHLKDASASTRLFQQACVLSNGSLLDADYGLAEAAWKSTKQSMSIQPMRAMAPFLALKRYLARIPNDDAALHLNALLAEQLGSSLLAARQIERASVLIESEFEATESVANAVRYGMASLNLGRIRLGKADTQGAIDAFEAALSLLEDAGDEHPIPATRAWSAIGLGWAQCLVGDTASGMAGLQQVLATLPSLSFAEEDMPQRIHASAAVLLARFQWRLQVPVAEIAAGLDAALDVAPQDPLLITTRAALASVVGDVSQYNMVLAKLVAPLPPAAQTSLRNAHKTAMLSMLHLAASFDTPTLLQHLASSYTRADNTTDTLVFVAHTHLRVAAGCAVQGKPLPALPLPEGQDGNLLPLARQVLSTVEQRASTEGLTHWSTMQWVVGLAELMCTEHATQTTVDPAPSSVAAQRHSAKAVHLAPWSQEAWNALRVASAAPSDKKPTVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q942</accession>
    <name>A8Q942_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729372.1">
        <property type="nucleotide sequence ID" value="XM_001729320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q942"/>
    <dbReference type="GeneID" id="5853679"/>
    <dbReference type="KEGG" id="mgl:MGL_3407"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3407"/>
    <dbReference type="InParanoid" id="A8Q942"/>
    <dbReference type="OMA" id="TNIITWI"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="317" mass="34654" checksum="27689B0FA852569B" modified="2008-01-15" version="1">MLRQFLFYVTVVPLSAPYLEQQWGTKELLLFSTIVTIVTNIITWILALLISTVQMAVGISSGKLSMLHSHFDGMHIILTGFLVAYAQLMQDQSVFWVYSYRIRDLLMLLIGLTNIPILLGIVAPFLQVQVAWIVAWVYLRFYQYGAAGQRGDASESFAFVEYFPSFIRPFLSPVMHSVHRIVSAWGLLPSAARYTDLELSIANVPLVDARTEAERRRTMALSALDSRSSSDKAQMQADSDLASRRPAKGVVPGTDRDAGHKLWLGSDNEAAPISGFSAASTPIPRPMPSMTSTAPGPASRIAAPSMAGADLSPSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q960</accession>
    <name>A8Q960_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylisocitrate lyase</fullName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729383.1">
        <property type="nucleotide sequence ID" value="XM_001729331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q960"/>
    <dbReference type="STRING" id="425265.A8Q960"/>
    <dbReference type="GeneID" id="5853690"/>
    <dbReference type="KEGG" id="mgl:MGL_3418"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3418"/>
    <dbReference type="InParanoid" id="A8Q960"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="220" mass="24519" checksum="43BCF28068D44975" modified="2008-01-15" version="1">MSSKTQKEFKDAASKLSNKAARDLAAKYGIDASSGFFWDWDAPRTREGFYQYRGGTQCAVNRAVAFAPYADLLWMETKSPILAQAKEFADGVHAVYPNQWLAYNLSPSFNWDAAKLSEQQMKDYVWDLGKLGFVWQFITLGGLHSTAYITDLFAKGFAKEGMKAYVSLVQRREREIGCDVLTHQKWSGADFIDNLLKTVTGGVSSTAAMGKGVTETQFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9J8</accession>
    <name>A8Q9J8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial GTP/GDP carrier protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729459.1">
        <property type="nucleotide sequence ID" value="XM_001729407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9J8"/>
    <dbReference type="FunCoup" id="A8Q9J8">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9J8"/>
    <dbReference type="GeneID" id="5853766"/>
    <dbReference type="KEGG" id="mgl:MGL_3494"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3494"/>
    <dbReference type="InParanoid" id="A8Q9J8"/>
    <dbReference type="OMA" id="GQPWFSD"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="159"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27370" checksum="67836BAB5FAC38B5" modified="2008-01-15" version="1">MTVLFKEKAHAPMMTRFLSLFPGLGYAAGYKVLQRIYKYGGQPYFNDYLTKHHKQQFESVFGERTGKFMMNATAGSLTGIGEIVLLPLDVLKIKRQTNPEAFRSRGFVRILLDENVNLYRGWGWTAARNAPGSFALFGGSAFTKEYLFGLKNYSDATWTQNFVASIAGSIASITVAAPLDVVKTRIQNANFESKVGGVAIIRDMIKNEGFTAFFKGLTPKVLVTAPKLVFSFTLAQSLIPWFGKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA51</accession>
    <name>A8QA51_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729143.1">
        <property type="nucleotide sequence ID" value="XM_001729091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA51"/>
    <dbReference type="STRING" id="425265.A8QA51"/>
    <dbReference type="GeneID" id="5853449"/>
    <dbReference type="KEGG" id="mgl:MGL_3610"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3610"/>
    <dbReference type="InParanoid" id="A8QA51"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="15"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="390" mass="42803" checksum="9B58CDAF0281517C" modified="2008-01-15" version="1">MRHASDWWRPIAAMQSNRQKMSASVRDEAATLAYRLARYIGSEQDLRALGLPSADALMELVCQHETNAFTLADAHLNPLGVCIEPTFALINHSCDPNAVIVFPDRVRGMPSKMHLVAIRAISAGEEVRISYVDVASCQAERQATLLERYCFACECRLCKRMGWRDPRMALWCPQPKCTGWVVFQNAASSWTACTQCEQVPNYVDTRALDAAPALVRHVQQAMYAQDESATLPSSSIICDTLRQLCTQALPSHYSVWPLLYAAHTLAIEAHAWHDAVQWTMLLCVGMQAGERTSQNEISTALYPAGHPQRAVLLATLARLLCQDAVLGLDSLVRSVTRALAWPPIHLDAPDARGRLAQAALVQALQEAMVAFGKETGGGAIGAEIRESLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA54</accession>
    <name>A8QA54_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3613</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729146.1">
        <property type="nucleotide sequence ID" value="XM_001729094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA54"/>
    <dbReference type="STRING" id="425265.A8QA54"/>
    <dbReference type="GeneID" id="5853452"/>
    <dbReference type="KEGG" id="mgl:MGL_3613"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3613"/>
    <dbReference type="InParanoid" id="A8QA54"/>
    <dbReference type="OMA" id="ARIVCIH"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04421">
        <property type="entry name" value="Mss4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="128"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="691" mass="75707" checksum="9C6965623B41D88A" modified="2008-01-15" version="1">MPLGRATKFGSQAAQDSASHLSSSPTSEPVSHVSTSPQSHLLSQTQSQAQSPSAISPSHSQPQSLPPSSSAQPVNVPRWPSGVPTSHGPSRVEHTNSRKHLSREHSTNFSSSLRRQRSNSRSASKSSFTIDTLRPDEIRSAIAVLGSYFPREETPSSSQLSARVDRAPHLTLGVFVSLPPPMVAGPLSVSGDLRRRLIGVLSATAAPAHIMQSMYGHSQSSLARVVCIQDFGVEQGYRHQRIGSRLLSEFIRRLQVPEYGSAPHQQEYEIVSVVCPMKRRSFFEEFGFRFHSFSYESRAMDPWIEMRRHVSGHVLPSLDTSFAQEDWADQHSLLSAISSPATQGLSFNTTRADMAALSLSTSSERGLNTRPASPLPFGAMSFSPANMSPLDTTSATSNEQSISFLLHKAHIGDGAARDLGLAPPLSARPQPKRNPGKAFEAIFGEAMASKTFSETFQTALKSRIVDFKYGLNLYPLLCPNEACDCTLVARKSAEWTMRETGPLTDTVASIKGEDTSSHVDNPEVAHAPWAIAMSQACTESTATIGPVRGFWHVPNPMGFDNVTFTRNMEWTVPSPTTPLPTSMARTSSSSNQHSRRRDSRNSMSTLRQTLRMHEAPQRESSDSAVPDMPDDCHWDVTPGEVRTIKYIMCPDCGCGPLGFSILPRGTTEESQQSVMQNNDCYLAVFRVRYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAA1</accession>
    <name>A8QAA1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729193.1">
        <property type="nucleotide sequence ID" value="XM_001729141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAA1"/>
    <dbReference type="FunCoup" id="A8QAA1">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAA1"/>
    <dbReference type="GeneID" id="5853499"/>
    <dbReference type="KEGG" id="mgl:MGL_3660"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3660"/>
    <dbReference type="InParanoid" id="A8QAA1"/>
    <dbReference type="OMA" id="PDGVYWA"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="145"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="732" mass="82519" checksum="3ACA9D0C9DA15D5E" modified="2008-01-15" version="1">MSGANQEYADHYIHHSTEPLGLRDAQAADGGAMPNEPASVPTEPSNTNMSDLTRYNPDATEMYKGDMNSPYDAPAMPSEAESAFNDILFPPDSYYHGTYWADLPLGERAKFINRQTGQILKDELIAVGRMFKRDPFSPISAYFSTYVVNGMGMFVEGYTLFSVGNLKPMFANTDVPKADNSFSGQSQFFRCWNSSDDMKKKLNIPKEQSGPERICDKQWLNAIDYLEIVGIIVGQILVGIEGDWVGRKFGMVQDALVMTLGSVMLTCMWGTSFNGWVICYAWSLFIYGIGVGGEYPMTSTRAMEGNSNRYASTTGDRLHRGRNVLLAFLMQGWGQFVNQVLLILLLLIFHSSLNAPISPVAAQYTFRVSFGIIAAFTLYLAYYRYYKIQYAEGALRDAKARLNTSGYDARSLALALTHYWHRLIASTVGWFANDFFFYGNKIFSGQFIKIINPGGTFTTTWLYNLINVGVQLPGYYLAALLVDNKFYGRKWMQAISFMATFALFCGATFAFNKLTDKNDMPRVKAFQFIFFFSSFWNQFGYNSTTFLVAAEIFPASIRATCHGVGAASGKLGALLPTIIYHYVGDHAKFYIVTWFGLAGLFVTLLFLPDTTGLDLREQERYWEYVMNGNAQDYHGVAIHPRHLSLFERVVLKRHLPYNPQLDAQQKMAEFRTVFHSTVGSGHYGEEDLTVQQREFLSSELGSKFSKDPKFVQNGGHFNDLHDSKLETLEKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAB1</accession>
    <name>A8QAB1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729203.1">
        <property type="nucleotide sequence ID" value="XM_001729151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAB1"/>
    <dbReference type="STRING" id="425265.A8QAB1"/>
    <dbReference type="GeneID" id="5853509"/>
    <dbReference type="KEGG" id="mgl:MGL_3670"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3670"/>
    <dbReference type="InParanoid" id="A8QAB1"/>
    <dbReference type="OMA" id="FECEARA"/>
    <dbReference type="OrthoDB" id="21151at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Myosin-binding" evidence="6">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="676"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="709" mass="79656" checksum="12F3B9680E910C28" modified="2008-01-15" version="1">MTDLIREAEAVAYAPDHGLYEFSEKFKYTIATSYLLAPTLSISMYERRSDDEQMRPSKSNDSCPHTNIYRVPFPNAQHHVSGSIRPAIPLIHATGAVILFCALIAFRVPIAYVILIMVALDALTLMPVVSESALWRPRTLSFYMSSPPTKHPSFLAANVPNPIWMADERVRLQACILLQVQEFVAAAQAMDHSINDALAAVQEVELVSRGHKLTSPLAPISRIETAAYMGDEGMPQMRRATYPQRLVSLRKEMVDALEESTYFCDAARRRLEKHQVVDDQLARGLTTVRHKPKRGELTLSTSPTPRTLSLTSTGTPTHTPYRKAQLPTATYSSQTEPSDILHHRSLISPLPGRSDVSDESPGGYFQQRPSGQDRLTLLSLRTGFEGMHSARQSLLYALLCLDWDRMHVHSTYESLLSFWNTEVLQGVLNSLTTHFRHTAQRMNRQLEQHMIQDTAPMPSTSTLLHHVGMGDCMTEMARMLRTIQCKLHVCGEELDLKTPSLHGMPNPSQETTHDEDKVRTVFESMREDLLALSSEWEAGSRILDPKPPELSPPAVEIPHFPETKSTMLHLDEDAQPINMLSDEKSEFQSGKHDSYMLHSLLLDSTSPSHLPAATGQEEVFEGASRSFGTRRVPPVSMLPRAERIRLMNEKRRKRADRADEFQPHFMVNELKGVLKRRTDTMPYRRSTTPPTPTSTSSTPTSSSRAIIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAB4</accession>
    <name>A8QAB4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3673</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729206.1">
        <property type="nucleotide sequence ID" value="XM_001729154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAB4"/>
    <dbReference type="STRING" id="425265.A8QAB4"/>
    <dbReference type="GeneID" id="5853512"/>
    <dbReference type="KEGG" id="mgl:MGL_3673"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3673"/>
    <dbReference type="InParanoid" id="A8QAB4"/>
    <dbReference type="OMA" id="RIVNECQ"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="180" mass="20931" checksum="FE0B8AFEE663A994" modified="2008-01-15" version="1">MNRSNPAFLNKLRSMVDDPNTDELIRWSAAGDTFLVPNHVRFGEEVLPRFFKHNNFSSFVRQLNMYGFHKVPHIQQGALKSDQPSQSELWEFSNRCFHRDHPDLLSKVQRKRSGKEREHQHTNSIDESNRVLHNMSGALTRGDFDSVGDPQECIERCRPCADDESTKCYPRYQEQSAHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAC1</accession>
    <name>A8QAC1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729213.1">
        <property type="nucleotide sequence ID" value="XM_001729161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAC1"/>
    <dbReference type="FunCoup" id="A8QAC1">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAC1"/>
    <dbReference type="GeneID" id="5853519"/>
    <dbReference type="KEGG" id="mgl:MGL_3680"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3680"/>
    <dbReference type="InParanoid" id="A8QAC1"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="5">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="411" mass="46039" checksum="3A5EE968A9BDD8E6" modified="2008-01-15" version="1">MRPDSRTVTKRDRKRIHNLQKAYQKQVSKHGEPPILFDILDLIGKSRVDEILSKNQEFERVPPFGQEITVKIERLSSHGDGLALTPQGDRLLAVPFALPGEVVRVLPYASERLYFKSRILELLEPNLTMRDPSLVQCRYFGQCGGCQYQMIPYAQQLEIKREVVRRAYANYSRLDASLVPDVLPTMGSPETMHYRTKLTPHFDLPAVLRRTHGTDLPVDMSVSVPIGFDNATTGRVMDIEECPIGTHVLNEAMTHERQRVRDSIRSYKNGATLLLRDSLCSADSDASTVVTDHKATVHERVGGTTFSTPAGAFFQNNRSIIPLVMDYVKSQLPSKSSPQYLVDTYCGSGLFAICLAPLFDQVAGVEISTSSIECAKANAKQNNVQNATFLAGEAERIFSVCIVWTMHMTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAE6</accession>
    <name>A8QAE6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729238.1">
        <property type="nucleotide sequence ID" value="XM_001729186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAE6"/>
    <dbReference type="FunCoup" id="A8QAE6">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAE6"/>
    <dbReference type="MEROPS" id="T01.A02"/>
    <dbReference type="GeneID" id="5853544"/>
    <dbReference type="KEGG" id="mgl:MGL_3705"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3705"/>
    <dbReference type="InParanoid" id="A8QAE6"/>
    <dbReference type="OMA" id="KQHLFRH"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="10">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="285" mass="31034" checksum="ACC23203FE4618F7" modified="2008-01-15" version="1">MTRVVDINEQRGSGFDFSGHLRNASLSAQGHAVPRATSTGTTIVGLIYKDGVVLGADTRATEGPIVADKNCEKIHYITDSIRCCGAGTAADTEFVTNLISSNMQLHALHTRKRPRVLAALTMLKQRLFQYQGYIGAALVLGGYDSTGPQLFTIAPHGSTDKLPYVTMGSGSLAAMSVFESAWRPEMEEQEAVNLVVAAIEAGIFNDLGSGSNVDVCVIREKETKMLRNYRRPNERAQKEQSYKFARGTTAFTKEEIYNMIVKEDVLQLDQPATTGQADAMETDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAK4</accession>
    <name>A8QAK4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729296.1">
        <property type="nucleotide sequence ID" value="XM_001729244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAK4"/>
    <dbReference type="FunCoup" id="A8QAK4">
        <property type="interactions" value="608"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAK4"/>
    <dbReference type="GeneID" id="5853602"/>
    <dbReference type="KEGG" id="mgl:MGL_3763"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3763"/>
    <dbReference type="InParanoid" id="A8QAK4"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="24995" checksum="4855ACC3CBD215D8" modified="2008-01-15" version="1">MSCVTLDAKTEAAKLVQDYFKSQLSRAASAKPLLDLMLSSSENRPILFILHERMINLPPQVMPPLLRMLLAEVEETLAETSAPAPTHALFFSRAFSADALDEGRGDSNEADDTGNDEEPSGLAGARKRKASGKHAHPVDAANAALGRQVHNKKRPGVTNEHDDGLGSFHPEDEFIREAATHSYTFRFPAPRDASETFEPPLYGRILAVPYTKMPAVLERLLEIWPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAN8</accession>
    <name>A8QAN8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3797</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729009.1">
        <property type="nucleotide sequence ID" value="XM_001728957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAN8"/>
    <dbReference type="STRING" id="425265.A8QAN8"/>
    <dbReference type="GeneID" id="5853316"/>
    <dbReference type="KEGG" id="mgl:MGL_3797"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3797"/>
    <dbReference type="InParanoid" id="A8QAN8"/>
    <dbReference type="OMA" id="DEIQWHM"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="485"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="579"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="583"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="721" mass="78451" checksum="9C8EC10786025016" modified="2008-01-15" version="1">MDHSRQFGARPLRLTAQQPSLKLPPAKTQGVQRAPRPALVDVSNRDTYSQNQPPAAAVSLPQFKPPLTKQASTGSIPLPAVAGPAPAPAPAPAHAPAPVPTSSQAHMSVPMPVPVSLPVSTGAPTQPPAPAFPITRRLTLMEPVAPQASQTKPQAPLQLQPQPALPSHPHPPALPLSQSQSQSQSLSQLQLQSQPPQTQSYSHFPSHPHVSTQTHAHLPSQPADHRQMSAPPSHAAHASTSLPMPVPTTATAATAAVGAPASAPASAPAATWLSGTSANLRRFSTVPGSRTSYVPSAIPNALPVVLPVRSDGQGGASDVSMATDTSMHAAATIDTTPEDILPQSRSSVSVRSDDSEVLAELEMDLDPAGIVTLTLDQEVIEQRRVLDISDRFEMCVLVPQALAAQSERRDLVRHGQMAASAAAHDDEMMRLGLDTEEARDISMVAEYAQDIFDYMACTERESMANPNYMDFQDEIQWHMRATLIDWLLQVHMRYHMLPETLWIAVNLVDRFLSARIVSLAKLQLVGVTAMFIAAKYEEILAPSVEEFVYMTDGGYSREEILKGERIVLSTLDFNVSPYCSPYSWVRRISKADDYDIQTRTLCKCLMEVTLLNHLFLRVRPSMIAAIGMYLAKRMLGGLWDDAFVYYSRFSEAQLLPGANLILEKLMEPGFEEQFVYKKYASKKFLKASIYARNWALRHRTALSAASKSQSPSSSASPNDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAR3</accession>
    <name>A8QAR3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729027.1">
        <property type="nucleotide sequence ID" value="XM_001728975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAR3"/>
    <dbReference type="GeneID" id="5853334"/>
    <dbReference type="KEGG" id="mgl:MGL_3815"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3815"/>
    <dbReference type="InParanoid" id="A8QAR3"/>
    <dbReference type="OrthoDB" id="3351759at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="71" mass="7545" checksum="C91B3306C39B6FAC" modified="2008-01-15" version="1">MHETDVAQRTKASPANVSDVSSPSLTSAQSVRDALSALAPHAPDAQPKFGILHRVYGDENTHYMGQGASLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB25</accession>
    <name>PMIP_MALGO</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial intermediate peptidase</fullName>
            <shortName>MIP</shortName>
            <ecNumber>3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">OCT1</name>
        <name type="ORF">MGL_3874</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EDP41872" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.24.59"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41872.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729086.1">
        <property type="nucleotide sequence ID" value="XM_001729034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB25"/>
    <dbReference type="SMR" id="A8QB25"/>
    <dbReference type="FunCoup" id="A8QB25">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QB25"/>
    <dbReference type="GeneID" id="5853393"/>
    <dbReference type="KEGG" id="mgl:MGL_3874"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3874"/>
    <dbReference type="InParanoid" id="A8QB25"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000055">
        <property type="entry name" value="Related to mitochondrial intermediate peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000338588" description="Mitochondrial intermediate peptidase">
        <location>
            <begin position="30"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="806" mass="90373" checksum="C7156509B4D06706" modified="2008-06-10" version="2" precursor="true">MLSRHLTVLRSACRVSHDLRVPSTQAVRKSAWSVCYSRRPLHISRSDAASTAALDMGVAPAVEKDHEILKELLDTRHSSGHVLSQGVPTGLFQIDHLRTPSDFLLLAQRTLIRCQLLVQRIARAIGNPSELARVVRNLDRLSDMLCGVIDMAELVRHAHPDQGWANAANDAYEYLCNYMNVLNTHTELYDALRCVMETKDIYHSLSQEAQAVAHIFMRDFEKSGIHLPPHERNRFVELSDQIMILGRAFLQDMSTGTSDTIVEFPTDLLDGMDTSIFAQNLFRLRPSKSIPVVPGSWELHYISKYAPNPQARRLAYMISYTGRTQPVAVLEQLLHARYELAKLTGKQSFAEMTLVDKMAGTPEHVLRFLRLLADAQRPVAQRMIAEFGQLKHALEGSSQVEIWDREYYADAYLQRHHPSQLAPLSPYLSLGSIFTGLSRLFYLLYGIHFRAAETLPGEVWHPDVLKLEVVDETESSVIGLIYCDLYTRDGKPPSAAHYTVRCSRRIDLDDTHLDMELGASADLPPVADTEHLLGVKGATGFGRPGRFQQPVVVLMTDFAPPNIGHGGACLLRWHDVETLFHEMGHAIHSMIGRTEFHNVSGTRCATDFVELPSILMEHFLTDPSVVALTAHHHRTGSPLPYVQLQKHLATQRSLDALDTHQQILLASLDQRYHSERAGAPTFSSSQELESLQADMGLFPPVSNATWQGQFGHLFGYGATYYSYLFDRAIAARVWEQVFAKKPLSREAGERFKMEVLRHGGGKSPWEMLSRLLHEDKIADGNAGAMEAIGRWGLGQNQSNETISAHL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB34</accession>
    <name>MDL6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Secreted mono- and diacylglycerol lipase MDL6</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDL6</name>
        <name type="ORF">MGL_3878</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Microbiology" volume="162" first="1069" last="1079">
            <title>Secreted lipases from Malassezia globosa: recombinant expression and determination of their substrate specificities.</title>
            <authorList>
                <person name="Sommer B."/>
                <person name="Overy D.P."/>
                <person name="Haltli B."/>
                <person name="Kerr R.G."/>
            </authorList>
            <dbReference type="PubMed" id="27130210"/>
            <dbReference type="DOI" id="10.1099/mic.0.000299"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">Secreted lipase involved in Dandruff and seborrheic dermatitis (D/SD) probably via lipase-mediated breakdown of sebaceous lipids and release of irritating free fatty acids (PubMed:18000048). Shows activity against monoglyceride and diglyceride substrates, but not triglyceride substrates and does not exhibit regio-selective production of diacylglycerols (PubMed:27130210). Cleaves oleic acid from 1,2 isomers of diolein on both the 1 and the 2 position of the glycerol backbone, resulting mainly in free fatty acids but no monoolein is detected (PubMed:27130210). Shows activity on monoolein and liberates mostly free fatty acids, but can also perform the reverse reaction and produce diolein (PubMed:27130210).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729090.1">
        <property type="nucleotide sequence ID" value="XM_001729038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB34"/>
    <dbReference type="SMR" id="A8QB34"/>
    <dbReference type="GeneID" id="5853397"/>
    <dbReference type="KEGG" id="mgl:MGL_3878"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3878"/>
    <dbReference type="InParanoid" id="A8QB34"/>
    <dbReference type="OMA" id="NWKFYPG"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00120">
        <property type="entry name" value="LIPASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728054" description="Secreted mono- and diacylglycerol lipase MDL6">
        <location>
            <begin position="17"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="54"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A8PUY1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18000048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="302" mass="33547" checksum="C5657A853FED26CC" modified="2008-01-15" version="1" precursor="true">MRLILLFLAFISFVLCVPEPRKVFGPTSYEEPTSLPVDLPLLSQAAGMAHEPYCHFNDEGKTVGDAEIVWTKWIGLAVQRAKIFHSKSLGVTVSFEGTTASILSILHDVNLALRDPPKELNDAYDEGSQLLSGFVDAYMDVRDDTYAEIVKCMQKYNDTRVTVTGHSLGAAMTALAAMDLEHRLEHGIYKAFAFAMPRTGNAKFASSVDNRIGGRFFYIANGRDWVPHMPPRDWGFQHPSGQVWINPVNSDNWKFYPGQENHFGANTVDPIWTFDDHHGYYFGTGVGHGPGTCPASVGTHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB63</accession>
    <name>A8QB63_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_3885</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728891.1">
        <property type="nucleotide sequence ID" value="XM_001728839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB63"/>
    <dbReference type="FunCoup" id="A8QB63">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QB63"/>
    <dbReference type="GeneID" id="5853199"/>
    <dbReference type="KEGG" id="mgl:MGL_3885"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3885"/>
    <dbReference type="InParanoid" id="A8QB63"/>
    <dbReference type="OMA" id="CVTHVGP"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="182"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP41677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="492" mass="53877" checksum="E12BE656214C1208" modified="2008-01-15" version="1">MSREAVADIGLIGLAVMGQNLILNMNDKGFTVAAYNRTTSKVDDFLANEAKGTNVVGAHSIEEFVSLLKRPRKVILLVKAGPAVDAFIEQLVPHLEKGDIIIDGGNSHYPDTERRCKEIEAKGLLFVGSGVSGGEEGARHGPSLMPGGSEAAWPSLKEIFQKTAAQTDGEPCCDWVGDGGAGHYVKMVHNGIEYGDMQLITEAYWILKQGLGLRESEIAHIFKKWNKGVLDSFLIEITSDILAYNDDDGEPIVTKVLDSAGQKGTGKWTAMNALELGQPVTLIGEAVFARCLSSLKSERQRAAKILTGAKPRAFEGNKSQFIDDLEQALYASKIVSYAQGFMLMREAAKEYNWKLNNPSIALMWRGGCIIRSVFLKDITNAFRKDPQLENLLFDDFFSHAIKKAEDGWRRIVAQAVLWGVATPAFSSALAFFDGIRSETLPASLLQAQRDYFGAHTFRVMPGKENDRLKAGEDIHINWTGRGGNVSASTYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB89</accession>
    <name>A8QB89_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728897.1">
        <property type="nucleotide sequence ID" value="XM_001728845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB89"/>
    <dbReference type="STRING" id="425265.A8QB89"/>
    <dbReference type="GeneID" id="5853202"/>
    <dbReference type="KEGG" id="mgl:MGL_3891"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3891"/>
    <dbReference type="InParanoid" id="A8QB89"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="112"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="216" mass="24397" checksum="BD2D02D5051B7961" modified="2008-01-15" version="1">MSSERDFERDYMSRPAPESRKFAPPMRSLSASKEAMFDVDSDDMDDVLSMPDPRYVPSITNRSPTKPNRKTSQSASESRTSLDLLGQSVRQISQSLPPSWDSEQLPDWLRRGAGVFEGTVNMANSILGAGIVGLPYSMRESGFVAGLVLLIGIALLTDWTIRLIVLNAKLSGPCYIYRYYGPLLRQARAYGRVDLSVCVCIWWHVRILCCRWRYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCB8</accession>
    <name>A8QCB8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3991</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728824.1">
        <property type="nucleotide sequence ID" value="XM_001728772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCB8"/>
    <dbReference type="STRING" id="425265.A8QCB8"/>
    <dbReference type="GeneID" id="5853130"/>
    <dbReference type="KEGG" id="mgl:MGL_3991"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3991"/>
    <dbReference type="InParanoid" id="A8QCB8"/>
    <dbReference type="OMA" id="RIAMSPY"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="53"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34549" checksum="A12A8738534E767C" modified="2008-01-15" version="1">MSRLGLQGLQRFTRCMPVAFHRTHMHKYMERPLWPAFRNGIRFGARTLATSCPTRVQTRTETSRSAMPKLPVQTVEKSATSSMPSPPPGSPLTSSTSPRSPPAAGPPHVTLSEDILTIPNILTLTRMSLCPILGWAVATHQAPLTLALLGVAGCTDLLDGWIARRYQSQTVFGSIADPAADKMLMATMVISLAIGGGMHWSLAAIILGRDVFLVALAFIMRYRSLSPPRTLARYFNPRLPSAHVTPTQLSKFNTFLQLVLVGVLTLFPLLPESVQTHPHTTRTVSVLEYVVAGTTLWTGVDYATSRRSVRFLHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCN9</accession>
    <name>A8QCN9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728863.1">
        <property type="nucleotide sequence ID" value="XM_001728811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCN9"/>
    <dbReference type="STRING" id="425265.A8QCN9"/>
    <dbReference type="GeneID" id="5853169"/>
    <dbReference type="KEGG" id="mgl:MGL_4030"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4030"/>
    <dbReference type="InParanoid" id="A8QCN9"/>
    <dbReference type="OMA" id="ICCRLET"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="189" mass="21064" checksum="20486A5A9552CAE4" modified="2008-01-15" version="1">MSWSLPATAYVARVKPQVDAPVRTHIAARSNLCVTDVTSNNINQVRRLNAALFPETSSEEIYKQALDKDTNSLYQLALFNDIPVGDICCRVEDGSDPTKCKIYVMVIGVLAPYRRLGLATVLIKHILNTAPPGSVFAGRRVESIYLHVQTSNEIARAFYERLGFALTQTIPSYYSHSEPTSAWVFEKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD25</accession>
    <name>A8QD25_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_4093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728758.1">
        <property type="nucleotide sequence ID" value="XM_001728706.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8QD25">
        <property type="interactions" value="586"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD25"/>
    <dbReference type="GeneID" id="5853039"/>
    <dbReference type="KEGG" id="mgl:MGL_4093"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4093"/>
    <dbReference type="InParanoid" id="A8QD25"/>
    <dbReference type="OMA" id="NEWNQMQ"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="1493"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="2261"/>
            <end position="2586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2054"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2067"/>
            <end position="2086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2629" mass="298078" checksum="7AF28B19EF8F84F7" modified="2008-01-15" version="1">MLEAMAHSIDGVDMKGDTPHLEILLAIVRQFLDDCEHVPATRTRLGHTVMHALASSFCSRCYEHHWHRRLGGWIGIDTLVRRASLGANWVADHQLEIVRALLYMLKDMPSDPPRDIERISATLYHVLEQAYTGKAPKHDANETTSRAAKVYNESSPHLRWLVGILIPELSSANEIARETTQRTLELLARLTECSVTELLEPQRDRLLLPIFTKPLRALPFGMQIGHIDAIRYTLQLPRPLPAFNEELFRVLTEALALADADDQALVGRTTLYKNLLAITKLRVVAIQLLAAAMQCTEFQTQEHVTMRMRIISVYFKCLYSLSDEVVQVAYHSLKATLAQQNKLPKDLLRSGLQPILMTLADRNRLTTAGLDGLAHLLQLLTNYFKVEIGVKLLDHLSALAEPAMLRRAAAGSLDTNEQLKTLAAIVRVFHLLPDTAYQFLPRLLMYVAEIESHLRRSGPTPFTDMLTLFLDHFAEHTIRYFFESDQLQNPRLLRLLRLALASDHGASLRRQLDERADVYILPLLSDASKTTHIRVALQLIEPLVAYGTPSSSSWLLVHRPVLDRLIALWNTPDMHAQRRAEADVLATQPPLTPLYLSLLHSALRHEPLVDVHMSLLDMYTYHQARDLSSHTRFVYEYVCGRGSVETKRALMQRVVHLIADPHAASVRKTYALRVLLNPMLVSSYAAEEAPLSVETQASAASSQKPECAHTIVSAANHEPLLNKEMVLLVVNQVWRIVQGHGMAMFTDDELRVELLQMSTLILEHGADVLAAEGTSKLDAIKFGWSFLPLEDVTVKHAAYLFISRFLQKFESPIKITGQVYVGLLRLTPSDGRALVRRALDTLVPALPERVPSKDGQTPLWVKWTKRTLLDEGHNVLQLCSILQLLVRYSDLFYDSRDLFVPHMVTSLAKLGFASSSTAESKKLAIQLIDLLIKWDLPSSADTDAQGGDAESVSRKRIKTGTDTYADSSTATLASASLSVSYSMPLHLRDLVFRFLVRFISLSMESITANDVTKHAFSLLEQVHRLPAWHGVQVRLALLQRALIHTDVSEQHVGPIANALATLDVISRDRDKEWLFSHMAQMQKLLEKTLASDHPVLLDAARPALERLCSVLPAAPPGEDDAPLPEDLAQLCTSVETAVTEGLRSGTNLASALTLLSAWSHTHPTCIDRHQPLLIKTLTRLTKEHLAAPAAGGESTLKMLMEVLQLLKARISHLGDQRRWFLSAVVQLVEKSSSTKLCHFLLSMMRVWILKEPEPFPTLKEKAGILVKMLCFEHRDLPLSKAFMDLILGIYKDPALARTELTARLEPAFLLGCCHADASLRREFIDLFDASLTRSMSARLLYLLGTQGWECIAQRYWLHQVLDLLLAAIDTSGPLVGEPCDGDNLFAQMMKSGTTQPFVNALRTLQYLDANAADALWQTLFPAIWRTTQKRHQTDLNHALIGCVTHEYMLRQAPARPNVVQSLLGGALACSPTLEIPPYVLRYLGKTFQAWYVSMEQLQHQLFSLRSDDAVRESTQDALAEAYAELSEADYFYGLWRRRCMFPETNAALAYEQSGKFAEAQVLYEAAQVKGRTSGVPLTESEYNLWDDHWVLSALELQQWDVLSDLAKLENNQDLALECAWRLSDWTAERESLERSLESLQVMSTPRRKVFEAYLALLKSQAAPDKPSDFGRICDEAIQLTLYKWFTLPVHVSQAHVPLLQIFQQFVELQEVSTVFASLAHTNATNLNHRSAELKTLMQTWRERLPNLWDDINAWSDLVAWRQHVFSSVNKAYLPLVSLIQRNEGPGSSTNSYAYRGYHETAWIINRFAHVARKHGLEDVCISSLTKIYLLPNIEIQEAFLKLREQARCHYHNPHELTQGLNVINNTNLMFFAAAQKAEFFSLKGMFLNKLGMGDEANQAFATAIQMDLNLPKSWTEWGRYNDSLFREKPAAMHFAANAISCYLQAAGLYKNAKARKILVRVLWLLDCDDAQGTLWQACDNYNGETPIWYWITFIPQLIQLLSHRQSKFARKLLMQIAKSFPQSLYYYLRTSKEDFALMKRNSLLLAQRALRAQGKEPQPQASQPGLAKDEVKPKEADEKDSTKDPSRYPADYVEEILNILKTAFPLLALTMENMAEQLQQRFKPSNDEDIYRLTNALLNDALQQYIHRAPLTSDNGQLPQTSQMNVKLFAENLPPGPLKAAFEGDFVTSKPNLHEYVARLRRWRDRYEESLDKRPRLQHLEHCSHYLVEFQHQKFDEVEIPGQYLKLQDNNSNFVRINRFLPEYGLLRSNGMCNRRITILSNKGSLHSFAVQLPSARYCRREERIFQLLRLLNTVLERKIQTRKRGLIFNVPTAVPISPQLRLLTYEESFISLQDVYERHCKQAGIGKDDPIVAWVEKMRSTWDGGSHRRTNVDFANLRMELLEEISVKMISDKILTNFITKTMASPSDLWIMRKQFTLQMAAAMFLTYILFISARYPGRIHLCRSSGAVIMSDMVPTFSPQAPHFKSPDPTPFRLSPNIQHFIGPIGIEGLVTSSFMALGTALTSSEHGLEDYLGIFVHDEVRFWFSGMQQHAKNLEPTIDLVKQNVLEIVKRARLMSCRFGQDKVRDLHYCVCLTICADNNHPNEPSRFRPNQLCKPSEQACPSGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD53</accession>
    <name>A8QD53_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_4121</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728786.1">
        <property type="nucleotide sequence ID" value="XM_001728734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD53"/>
    <dbReference type="FunCoup" id="A8QD53">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD53"/>
    <dbReference type="GeneID" id="5853035"/>
    <dbReference type="KEGG" id="mgl:MGL_4121"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4121"/>
    <dbReference type="InParanoid" id="A8QD53"/>
    <dbReference type="OMA" id="NGEVHKM"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="172" mass="19647" checksum="211E6763059BEB63" modified="2008-01-15" version="1">MTRPMICGEDTPKAPFPVYLRGTVEHGYGRGSKQLNCATANLPISALDDPVNDPQHRLHETGVYFGYAQVRFRDGAPHVAADREIYPMVMSLGWNPQFQNQQKSIEVHILHNYAADFYGEDMHVVVLGYIRPERKYANLEALMDDINIDKRVGLNSLDRPAYCAYQKENWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD55</accession>
    <name>A8QD55_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_4123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728788.1">
        <property type="nucleotide sequence ID" value="XM_001728736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD55"/>
    <dbReference type="FunCoup" id="A8QD55">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD55"/>
    <dbReference type="GeneID" id="5853085"/>
    <dbReference type="KEGG" id="mgl:MGL_4123"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4123"/>
    <dbReference type="InParanoid" id="A8QD55"/>
    <dbReference type="OMA" id="LAHHNAI"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="297"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="553" mass="61032" checksum="F717FCBDCEA1F57F" modified="2008-01-15" version="1">MTSSGDGLALSSTQRLVRGNVTPSRASRFFLPRTPCPRQDPLCTPERGTSAVIDIEASTPYSGMSPYDADHTQQSLSSSPASSEVLTPKHECEREWPSSPTLDRKRPRAQRSYTPTGHARLDCIEDVPALSLTRHAETRTVSMPSSMSRYPLATHAGPRIPLAWQRVQSRFTSHARHARAFLSSFRTDADSYYHLESGCIPHGTSSPLSAAYMHSACATRDTPQCLAVGDDEGRVHLLDTLRPPHAPDACRHVTEPLLHGSIFALDWRKDDRVIALGGSDYSVSAWDVEHQLCVASYDAHRGSPRALAWDPNEAAGGRILASGGRDGDVYIWDLRMSEAALHIPRAHGMPRTRRLPTQERQRPRPRRRALQPTGSAGVTALAFVPGHGLATACSENAIVHVWDMRKAHCSASSVDCSKRASWNTRPHGISSLVVAHSRREMYAACTDGCIYVLNTDDVARPLIPGRVCALHHEIQRQNTLYARLALYHDTYLALGCHSGDVVVWDVSKPMSMTPLVDEAGISREGGIVLPRAHELKYVLMHTRTPRRKKKTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD81</accession>
    <name>A8QD81_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4149</name>
        <name evidence="8" type="ORF">MGL_4155</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
            <strain evidence="7">CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728670.1">
        <property type="nucleotide sequence ID" value="XM_001728618.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728676.1">
        <property type="nucleotide sequence ID" value="XM_001728624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD81"/>
    <dbReference type="STRING" id="425265.A8QD81"/>
    <dbReference type="GeneID" id="5852972"/>
    <dbReference type="GeneID" id="5852986"/>
    <dbReference type="KEGG" id="mgl:MGL_4149"/>
    <dbReference type="KEGG" id="mgl:MGL_4155"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4149"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4155"/>
    <dbReference type="InParanoid" id="A8QD81"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="171" mass="18450" checksum="A14862C843086D97" modified="2008-01-15" version="1">MIYLLARAAGATPIILVDVALSRLEFAVQQLGANIENVVHVDANQSMAEASTKVLQAFKGIKPDVAFECTGYSMPIHTCLGVLEAGGCLVQVGIGAPVNELSFSELLHRQVDLRFVMRSNSCFEDCIRLVENGVVDPSLLITHVFPIQQASEAFRTLSQPESGAIKVHIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR23</accession>
    <name>A8PR23_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF455-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732804.1">
        <property type="nucleotide sequence ID" value="XM_001732752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR23"/>
    <dbReference type="STRING" id="425265.A8PR23"/>
    <dbReference type="GeneID" id="5857110"/>
    <dbReference type="KEGG" id="mgl:MGL_0579"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0579"/>
    <dbReference type="InParanoid" id="A8PR23"/>
    <dbReference type="OMA" id="LAWDTIV"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007402">
        <property type="entry name" value="DUF455"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42782:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42782">
        <property type="entry name" value="SI:CH73-314G15.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04305">
        <property type="entry name" value="DUF455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45204" checksum="C15B4C1122D46DA2" modified="2008-01-15" version="1">MLCYLSRVCHPNHLHQQYDFSLSTGDSSTGLRACIYDVRVDELGIVYIEPPTPESTWSCKAIQPVPSEFAAIPPPPPESTTLAQLGHIHLFDPDAVKPPDPEPQTLIAWATLILNTASPLHKIAYTRYAKNAFDRGISIGGGHWDGATWHVPANEQPPERPPRLRDEQRVEPGQQSKRGRGGSERSRIALLHALANIEQWAIDLAWDIIARGPRLSARYMQTETNQTPEMPLPRAFFADFSQVALDEAKHFTLLQQRLIEMGSFFGALPVHHGLWDSAIETAEDLCARLSIIHLVHEARGLDVNPLTIQKFRAAGDALSVESLTTIHLDEITHVSAGHRWLTYLCHVHPEHPSPVDVFRSSVRKHFVGQLKGPFNVDDRQQAGLTPQWYEGLCGEKHAERHVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR33</accession>
    <name>A8PR33_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0589</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732814.1">
        <property type="nucleotide sequence ID" value="XM_001732762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR33"/>
    <dbReference type="STRING" id="425265.A8PR33"/>
    <dbReference type="GeneID" id="5857120"/>
    <dbReference type="KEGG" id="mgl:MGL_0589"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0589"/>
    <dbReference type="InParanoid" id="A8PR33"/>
    <dbReference type="OMA" id="EYIVTHA"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="336"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="995" mass="113591" checksum="EC1289E39E21BF14" modified="2008-01-15" version="1">MSADGSESSSLTDALYRGQNRFLSALNLRKPRSPEPSRQPGEQPQPLNQGRGARSDIEHRSTSSSPTPSQATSTTTSQSSVAEERLRKLEDQRAFERMVNMRRRVSAANAALIESPEQKSRYGEWDAYHVETNEWQHLSDVLAMSKMAEQDPSRLTMCYGTEWRFRARIHVIRNMSSHLAFVVLREHGVTMQAVLSEHGTNITSHMMHWVMRLPSESLVFVQGTLQKPREVITGCDIAHLELHLTHVHLVSGISEKMPFTVYAAERALSSHLEEHQDLDEDESLDHSSSVLSDADRQSQRSTSHVPVITQRTRLSNRLVDLRTPTMQAVVMIPSVICREFRQYLSQHEFIEIHTPKLQGGASESGASVFDVAYFGRSAFLAQSPQLYKQMCIAADMRRVFEIGPVFRAENSNTARHLTEYTGLDLEMEINHYYDAMSLIDRMLKHIFTVLRDKYGHVTQFIRRHYPSTELQWLEQTLVLPFWEGIRLLKEDGYREEDGSEPSPFEDLATRGEIRLGEIVKRLYGTDYYILDKFPRNARPFYTLPDQNDERYTNSFDIFLRGQEICTGGQRIHHAQMLEDNISRLHMDASSLEDYLEGFRLGAPPHAGCGLGLERLVMLYLNLDDIRLASLFYRDPKSFPTKPPQTLRYLEGSTNPPPWLQAASSSGSDSRTEPGEKQLQPLELLIANYGDSTNTSWLDDRITVWRDQDTGAAIGYWYQRHYVLIVGNPLCDMSQYNRVIERFLEFVERELRAKPIWLMVSEVVESILGSRFGWCTLTCTDDQRIPDVRKNPAKHDHEIERKIRHADKVGVSIQSFAYHEIVPEDVRAECDEKIKEWSASRRGTQVHLTDVRPWVDQEHRQYFFARDSDRKLCCLVVLAQLAPIHGAQVKWALNFPNAPNGAIEMTILHALDTLGSGSVTFGTAASPKVKAVHGLSGLAFKILSRVYNSVSERTHLLSKGDFRDKLGTVRDPTYICYPKGGMSMLAVREVLNFFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR37</accession>
    <name>A8PR37_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732818.1">
        <property type="nucleotide sequence ID" value="XM_001732766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR37"/>
    <dbReference type="STRING" id="425265.A8PR37"/>
    <dbReference type="GeneID" id="5857124"/>
    <dbReference type="KEGG" id="mgl:MGL_0593"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0593"/>
    <dbReference type="InParanoid" id="A8PR37"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="444" mass="48656" checksum="23FDB6F726D81BC4" modified="2008-01-15" version="1">MASEQLIQCMAYLGLKSPFSSSTPTPPVASHPPSRLPSAITSFFDHVFPAERMPSRKIIVYTMGGIICVGLGVLTMPYVSTYVQHHLRSSRLPLKGAISKDGTRRQCVIVLGGDTILGSEFVRHFLAHDLIVLASASTEQSVRELESNVPSESQGYIRLFQLNPVAASDKEMTKFVHAIHASLCMRFPWNATGDPYARPGSTVELVGIVNALSYVPDMIDWTSHSGNTESPLAALEPKDVDAALHKHVSAPLSVLSRLLALVTTSKPHKPSNLPILVVHIVSLPGARFVWPAHGATAMIAQAAQTGFTSLRREYTQEWMASLTSTHVPWHQNTGMERKISWTTFQVGPGAMTSSGVSRLLPKVTRLILTPVRSLSLSYTIFGGSLWHAMVMRCIHAALRIVPTTWLDVIISVHERFLERHNTRARVQQAHANPHPSSLQPGVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR48</accession>
    <name>A8PR48_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear control of ATPase protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732828.1">
        <property type="nucleotide sequence ID" value="XM_001732776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR48"/>
    <dbReference type="STRING" id="425265.A8PR48"/>
    <dbReference type="GeneID" id="5857134"/>
    <dbReference type="KEGG" id="mgl:MGL_0603"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0603"/>
    <dbReference type="InParanoid" id="A8PR48"/>
    <dbReference type="OMA" id="VARMWRS"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59863" checksum="962B60A5212EB7D3" modified="2008-01-15" version="1">MWTSAMHASLSDALHALPPPTPGTWSAQTLLRLRTCAALCTALARARNAGAKDADLARIVYATYLHVTTTLISDAQALEEAEAYWRRVTRDHMRAGLLWLQTLPERLVWGRRQTKWIGLHGVRAEAEAKCERLHRAYEATARALGALAIAWHTSSSSNLSMSERAKTLCKEGWLALSSDLPSRPKDHLSHTTAAFLDAVVTHEAGVSRVLRACGIPSVMTHAWPLLIVYPLVSWGATSLVYRHWTQITTQMAAAWETVQGLVVGWVYVPALRLLDTLRAGRKERALLVRRESLAADEQSLERMVESLGRDTLQLDPAALADLAARTRAGDLTPVWQVYEAAMRSPVRGFVSGSLVRTLLIHVQKAKVDLEIALSGIDWLLKSQELLLGAVGLAPALGLVYVLYASVRGSVRWLCQKPASLRASSTTQLRMDAWQALRRADARCCYCRCASSASSSHGPVDANDPASSRSMALLYGRLLLDLRVLRTSLAALIKHACHGDRLVHARLLSEADADLQALECADAWTDRANVVARMWRSWGHLISVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR93</accession>
    <name>A8PR93_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732859.1">
        <property type="nucleotide sequence ID" value="XM_001732807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR93"/>
    <dbReference type="GeneID" id="5857165"/>
    <dbReference type="KEGG" id="mgl:MGL_0634"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0634"/>
    <dbReference type="InParanoid" id="A8PR93"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="321" mass="34525" checksum="5ED29294F8957EDD" modified="2008-01-15" version="1">MPSLATSDRIAINDVLEQYKPGEDSMVDTSHSLLQNPALSHAPSRTNLAPPITAFLGNPSVGMGSQWVHEDVSLSAYIRDENTTQEDPGMRTGTTTTGARPDASSVADAAAFTNATSEPSARVSAPAHVSATRHASERAAPSRDTSLHQPDEASEQDAQRPTNMPTASRVHVVGTTRSSPTKKAPDMTSVYDSLPTPRTNEIFPDGLFTSVVTPVLDQSSASERPARVPDDFLTTTNESISREPLLDRADLDKFLLAGDDENALHIKLDERAPNEGEQLNAEPEQTVSKANDREPVPEGVNTSMSYHPQNTVSERRGYEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRB4</accession>
    <name>A8PRB4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Symplekin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732238.1">
        <property type="nucleotide sequence ID" value="XM_001732186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRB4"/>
    <dbReference type="FunCoup" id="A8PRB4">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRB4"/>
    <dbReference type="GeneID" id="5856538"/>
    <dbReference type="KEGG" id="mgl:MGL_0013"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0013"/>
    <dbReference type="InParanoid" id="A8PRB4"/>
    <dbReference type="OMA" id="NVRYGIM"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="737"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="968" mass="105695" checksum="619F84C00BC4D194" modified="2008-01-15" version="1">MATYAKLACECFASVYPRVFLYVNQDRSPVSHHLWQIVTAIKERIQLTLDGGALGARIGAAKACQRLIQVQTRPDGDPRLQNRAEINLNAVPPDHPFLQTATLEGEADQVFTKLVALLYTCKAPSLVMGVTQVLTRLARLRSKLNKVVIEAFVSWTPSALTSLAPVHIRSVENTVRLAMVHFLQHGSVEPQTTQLTHALERQKQRMDVALREAQAAQRDGLSRKREALKDSDGVMASKRSRASTPTDPRRPAGLTAHDIARLPLEQVVDAIIAGLQSVPEKRLKTAIASFVSAVSPAAPTEPVDPLKMDVGDEDVPVVPASAAGAAVTTPGTAITSDAGSGGLEAEDTAPLASLEHFELPEPARLEQREAQALIIDSVTRICESGSQLVPPQALERASEGHAALWIKLVVRLATRGLDMYGTNATPPPELQAQADKVRALLLDFVSQDFSARRGIALQWLMEEWACDRLRQKQGAQSEHYLMCLDKMLDTQLSSPNIDDIALGTFLRELPQVPLVVLDRLYELCLDRSTIGEGFSLLRDVSAARPPLRVPVCHKVLQLTRHSERLVRGRAIVTARTWVLQKGPLAEVVLSFARESLQLLVEEARANETQEEAQDTSVEAEEADETAADPLGLSEQDVLRLIELALVLSVKQPSFFAEVVRIYPHVPAPVQAAMQKHVTPVARSVGPNSTALLDVLRAYPEGADTLVVAILRILTDKGHTRALAELVRDLVETRDLSVEYLLPLVPQLDRDAMMHALPRVVSVLADGSEEHKVAVHHLFQTLVAPAMQAAGAETASKQPTTTASLTPVELLVLLHVHEKQIGLKASLLAVQLCFSMSEVFRSDVLTAVLNRLVDENPLPMLFMRTAIMATKSFRTLGSYVSTSLLSRLVQKEIGKEPRLWDGFALCANLPAPTSFGAMLQLPAPQLLELVRKQPSLRDPLRDYLIYKAGGPARHGALLQMLDGNNGPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRE0</accession>
    <name>A8PRE0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732256.1">
        <property type="nucleotide sequence ID" value="XM_001732204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRE0"/>
    <dbReference type="FunCoup" id="A8PRE0">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRE0"/>
    <dbReference type="GeneID" id="5856562"/>
    <dbReference type="KEGG" id="mgl:MGL_0031"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0031"/>
    <dbReference type="InParanoid" id="A8PRE0"/>
    <dbReference type="OMA" id="PMLNDYR"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024767">
        <property type="entry name" value="PRP38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12871">
        <property type="entry name" value="PRP38_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 38 C-terminal" evidence="9">
        <location>
            <begin position="178"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="315" mass="35270" checksum="F042D61D5E5A1A87" modified="2008-01-15" version="1">MSNTTAFGAQAIHGTNPQFLVERVIRSRIYDSTYWKQDCFALNAATLIDKAVDLTYVGGTYGAQRPSPFLCLILKLLQIQPERAIVLEYLAAEDFKYLRAVAALYVRLTFPAIEVYELLEPMLNDYRKLRWRDMAGNYSLTHMDEFIDQLLTEERVCELILPRLTKRSVLESNDGLRPRVSRLEDALLRGEAPGLEDRRKTCDSDASDSDDSLAALRTERATRIAQADRLRHSKHAAVKPGAGTHANADTDADSEVYASQQSESEEEKLQARLIRSRTPSVSPDRQMSPKISARSGSVSPPAFQSRSPSMSPSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRP9</accession>
    <name>A8PRP9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732326.1">
        <property type="nucleotide sequence ID" value="XM_001732274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRP9"/>
    <dbReference type="GeneID" id="5856632"/>
    <dbReference type="KEGG" id="mgl:MGL_0101"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0101"/>
    <dbReference type="InParanoid" id="A8PRP9"/>
    <dbReference type="OMA" id="HARMASM"/>
    <dbReference type="OrthoDB" id="3366517at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="414" mass="44221" checksum="C5288792980947D4" modified="2008-01-15" version="1">MRLTALPIPSLPSQPSSSPSSAVASKATLCDTRSEAGARPQTPIPQDHYASQTARERLARVASAPQLGSPHHRTQKSSDLHNYPTPELLLREQKGVTDVSHKRRRLASSTSPQTSIPSSSSTFRFPAPASSSSSSTLSSPPFPVSRQAHGSRQFAGLNGHRGASSASAASHGLGVACATSYPATFAPRRVPISHSGHVRNASMPEARRAHDHYVPIRGSDPVPSTATLSSSAASRTDLGLLRPPADPAQRHAHLSSAPHDNHVPRSHVRTQGRHLHPPQRGVRSHRRSISHSTVELSRPVFHSHDRNDRFTTPLAGVASLPTSNERGGGITTPPASAASLPDTPKSMGSKSLNHGDYLVMSPSPEPHTHTRDGYASRQAIKPSTPQRHAVARMRMSEVPNARSVCPLWAQSSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRT4</accession>
    <name>A8PRT4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732348.1">
        <property type="nucleotide sequence ID" value="XM_001732296.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PRT4">
        <property type="interactions" value="741"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRT4"/>
    <dbReference type="GeneID" id="5856654"/>
    <dbReference type="KEGG" id="mgl:MGL_0123"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0123"/>
    <dbReference type="InParanoid" id="A8PRT4"/>
    <dbReference type="OMA" id="SELFACY"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="7">
        <location>
            <begin position="54"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="6">
        <location>
            <begin position="632"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1266"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1266"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1401" mass="152026" checksum="9433216D8389D61A" modified="2008-01-15" version="1">MSEAAARQQQRLSDAQKFIEKWCQPGALTLPDVKARLPPREAPYEEHTQPDDAWTGFSVQRRLPIPSIVFETITSRAPVATLALFPDISRACITVENRLYLWDYANGQSAFEYHELPSDDLILAVGLVRVRPGVFIDGIKHVLVLSVGPTAVEGRRVTLLGVELLNSQQQQQQHQQQQPQSQQQQQQQTYSSSIPGAPTTPHASGSGIKLYETGMSAATNGIVMRAIHGTDSGRVFCVGSDQCVHELVYQAQEGWFRSRCYLYNMTQPHLANLLPSFFKTDKKVSMISIDNARQLLYVLRDGDQIDVYTLGSKDASRAPSHNGSMRGLLHSQQHVGPIVWLGPTEPDPRSSVCLVAVTERGYRLYLDDFQRRSWAQLALRIPPGSSHARSLPTVQAAPNLAMLYTGQGPGHPQLFTSTASSSTGAAPAAASVPMAQRATSALYVNGVFLCAFAASHTMGAHLYAMGPSSPATSATLTYASGVNPAWQEGATLIHLGAGGTAPVLAEAKVPASQSVLMHGAVCRPCAAQTTMPPRVFLVLDANGLTELVERRPADVLADLLGSAASAAASVSSAPAIVDFFSRHGPVEACMCALALAAQNPCVVPRHHARDDMAHAIRVFFGPLGAWPAEQRALACYMACLVRSVWREPLVPASYIDGREPASAAASPPPIVGSGRLAAVLAQMTPLYAFMQRHTQLFDDERSERQDVQKWHLLLQRMMEACHFVLFLADHQLRTLAKALPDDVQKRLTNLTFAELVASEQGRSVAQELVTALIESQSGARASVDAIAEALQARCAGFCSADDVRQYKASECLRNATELYARLCAESATTFDAVDEELAQSLRLLLPGAAHLPWDKLSHVCSTYEQLGYVSGVVTLALACARAADPADAAVSFRADGCPPDEPTSHRYAMYTLRRRMYALVLRAMETVEDGGGGGGSNSSSSRYANDAGTVTSSKLLLARPTAHKDAMSLALASDDALFHEELYTYLIAKGRTADLLSCTTPFLADFLLGTPVLLDGQSLETYERRLRDLLWQLYVRQGQYLAAAETLDALAHTDMYPLHLHERIEYLALAVGNAKSVRPSEAAAHVQDLVGFCTQVEEDLEVAQVQAKILSALPRLDTLDCEPEERAQLTASAAQLDRSLMDITSLYKEIAEPFGLLEEQLLILHTAQYQDADLVAQLWEALIAREHNASSPTQAHRAVAALVTDVYVRLNGSPIACALDIVLVLLERYAYDTYIASQGDMPLGSALDWHAFATVTRATSSVAAAAASPSPSSTSPAATDGPSTAKGLIPPGWAPRVLLEAGAPPDALFHVLQGLLSMAPAPWNTNRGVGFLLPDVAEFCEAWLRRTDQNKYTLFPAHQIEQVLSDALLQLHSRRYTRSDEALDARIEQIQALVHRVRRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS28</accession>
    <name>A8PS28_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732406.1">
        <property type="nucleotide sequence ID" value="XM_001732354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS28"/>
    <dbReference type="FunCoup" id="A8PS28">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS28"/>
    <dbReference type="GeneID" id="5856712"/>
    <dbReference type="KEGG" id="mgl:MGL_0181"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0181"/>
    <dbReference type="InParanoid" id="A8PS28"/>
    <dbReference type="OMA" id="VLCAEWE"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="303"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="350"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="489"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="531"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="573"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="604" mass="66819" checksum="4BAE8AF1DB07F81A" modified="2008-01-15" version="1">MATQVPKPSAKRQRRAAEAEKRANEELSESGMLNSNMSSVLVQFRSGQDDTFLGPTISLPAQVGQAEMAKLVNELRRQARSQRGRTETGAGEQDDVDEDEDIPYAFHVLLRETDTSTSEPTRVPIHNSLHDDVMNSAVAKKLGISMEDSLTIVFEPQAVFRVRAVTRCSSTLSGHGSPILCCSFSPSGLLLATGAGDKVCRIWDMDTEMPLHTLEGHEGWVLCVEWEPLERRLATGGMDGQVWIWDALVPPLPGRRGWGARSGEQVDAEHQAQQTQTGAEAPRKMSVVERRAARRAAPRGQMLRGHTKWVTSLAWEPVHRNASAPRLASSSKDGTVRIWNVVSRQVDFVLGGHTASVNCVRWGGDGAIYTASSDRTIKVWNDQDGRLIRSLNEHSHWVNSLALSTDYVLRTGAFDVKGAYAAHLCKQDYTDLDAFTQSMAQKRYEESTANGARPEMVVSASDDHTLFVWPPQVHSTEATMSPKKPLARLTGHQKTVNHVCFSPDGRLIASASFDNSVKLWDGRTGKFIANLRGHVASVYRVAWSSDSRMLASASKDSTIKLWNLKTFKIKVDLPGHEDEVYCVDFLADKLASGGRDRTLKIWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS58</accession>
    <name>A8PS58_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell division cycle protein 48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732423.1">
        <property type="nucleotide sequence ID" value="XM_001732371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS58"/>
    <dbReference type="FunCoup" id="A8PS58">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS58"/>
    <dbReference type="GeneID" id="5856729"/>
    <dbReference type="KEGG" id="mgl:MGL_0198"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0198"/>
    <dbReference type="InParanoid" id="A8PS58"/>
    <dbReference type="OMA" id="VWPAYPE"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="80"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="192"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="465"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="728"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="85779" checksum="D16977AAFAAAC89B" modified="2008-01-15" version="1">MEELGLFRGDTILIRGKKRRDTVLIVLTDEDTEDSKIRLNRVARNNLRVKLGDLVNVHACHDIKYGKRIHVLPFDDSVEGLQGNLFDVYLKPYFLEAYRPVRKGDTFIVRGGMRAVEFKVIETDPAEFCIVAQDTVIHTEGDPVRREDEEANLADVGYDDIGGCRKQMAQIREMVELPLRHPQLFKSIGIKPPRGVLMFGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKREKTNGEVERRVVSQLLTLMDGLKARSNIVVMAATNRPNSIDPALRRFGRFDREVDIGIPDPTGRLEILRIHTKNMKLAEDVDLEQIASETHGYVGSDIASLCSEAAMQQIREKMDLIDLDEDSIDAEVLDSLGVTMENFRFALGVSNPSALRETVVEVPTTTWADIGGLDKVKQELQETVSYPVEHPEKFLKYGMSPSKGVLFYGPPGTGKTLLAKAIAHECQANFISIKGPELLTMWFGESEANVRDVFDKARAAAPCVMFFDELDSIAKSRGGSSGDAGGASDRVINQILTEMDGMNAKKNVFVIGATNRPEQIDPAILRPGRLDQLIYIPLPNEASRLDILNATLKNSPVSSKVDLGFLAKHTHGFSGADLAEVCQRAAKLAIRESIEADRRRESERKDRGEDVKMEEDVALELEDDPVPEITPAHFEESMRFARRSVTDADIRRYEMFASTMQQSRGTMGASFRFPEGGIDGGAPTSGGNQPSETGGGAPAPAAFGNDEADDDLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSL3</accession>
    <name>A8PSL3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732503.1">
        <property type="nucleotide sequence ID" value="XM_001732451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSL3"/>
    <dbReference type="STRING" id="425265.A8PSL3"/>
    <dbReference type="GeneID" id="5856809"/>
    <dbReference type="KEGG" id="mgl:MGL_0278"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0278"/>
    <dbReference type="InParanoid" id="A8PSL3"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000538">
        <property type="entry name" value="zinc finger protein 853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="310" mass="35144" checksum="7B2D7D4309BEAEBF" modified="2008-01-15" version="1">MEEFTSQMQQAHVPDHDTKLLQEYLSTPIPLGSSREKENDTCITTIAPADRELDPSTDTGTDTDIDADTAAWCDHAVRGQCMLGEEEKALDDMATACFCPPAQDGQRKRHPCGWINCSCSFDTHAELTAHIAQVHVGSGKTEYECGWVGCERAMQGRKFTQKQKVLRHIQTHTGDRPYECPSCHKRFSEASTLTQHMRTHTQERPYKCDFPGCNKTFSVVGSLTIHKRTHTGDRPFKCPYPNCDKQFSESSNLNKHIRVHRGDKPFQCPECLRRFTRPDQLTRHRKVHDKSLSAPRARNIPTPTPPVLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSM7</accession>
    <name>A8PSM7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxypeptidase</fullName>
            <ecNumber evidence="8">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732510.1">
        <property type="nucleotide sequence ID" value="XM_001732458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSM7"/>
    <dbReference type="FunCoup" id="A8PSM7">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSM7"/>
    <dbReference type="MEROPS" id="S10.001"/>
    <dbReference type="GeneID" id="5856816"/>
    <dbReference type="KEGG" id="mgl:MGL_0285"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0285"/>
    <dbReference type="InParanoid" id="A8PSM7"/>
    <dbReference type="OMA" id="AIANNMS"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120516">
        <property type="term" value="F:diacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF452">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006521990" description="Carboxypeptidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="554" mass="61954" checksum="8FBA101E52F70376" modified="2008-01-15" version="1">MARISVVLCLLAFCAYVHAQFALMDSALSRFMSVTSQIFHTLKKPSSAIPLASWNPWTSNSRIQAGNLSAWLGVRIESIGGIKYQRLFLPLFPDYQLRVAMDENDDEENNDETPFCDPKVKQIKGYLDIREDAHLWFTMFESRSDPSKDPLVLWLNGGPGCSSSTGMLFELGPCWVSQQGEGTTYNEHSWNSQANLLFLDQPLQVGYSYSDSGEFVDTSNKSAEDVYAFLQLFFARFPKYADLPFTVAAESYGGHYAPHIGAEIHRRNKELANLPDNYLATAKPIRLDSLMIGNGLTDPPVQFPSVVEYACSPENKYHLFDRESETCKTLEAKSEVCTKLMNLCEKMDSRLSCVPAALYCWGSLYGPAQDTGVNLYDVRRKCDHEKDGDLCYPEMEHIETLLNKPRIKKMLGVPATVDFQSCNMQVNARFMMQGDSMQNSATLLAPLLADGIRVLAYAGEADFMCNAIGIHEWILDFQNVYREAINNATETPMFTHSVNGAKPRQAGFVIKAGKGAGNLAFAWIQRAGHMVPHDQPAVALTMLNRWLANEDLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT42</accession>
    <name>A8PT42_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial proton/calcium exchanger protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Leucine zipper-EF-hand-containing transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_0364</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LETM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732589.1">
        <property type="nucleotide sequence ID" value="XM_001732537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT42"/>
    <dbReference type="FunCoup" id="A8PT42">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT42"/>
    <dbReference type="GeneID" id="5856895"/>
    <dbReference type="KEGG" id="mgl:MGL_0364"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0364"/>
    <dbReference type="InParanoid" id="A8PT42"/>
    <dbReference type="OMA" id="QNEMIAD"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="15">
        <location>
            <begin position="250"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="635"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP45375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="696" mass="78829" checksum="1075CD81BDCC9ED3" modified="2008-01-15" version="1">MRSFGTRPRCAVVSLVTPLKGSPIRRPVHAHVSAHYDKGLRHARGSIRDHCLDSFVTQDDMSAPLVRLVAARAERQSALTLRIGGMWTIYAQQRMTSAAHRIPRGGGMPATPASRGVSTSAVRHSSSKDKDVTATTSSSSDNPKQSMPVRAWNKVKEEVLHYWHGTKLLGKEISISTRLLRRMIMGYTLTRREHRQLRRTMGDLLRLIPFIPFILIPAAELLLPVALRIFPNMLPSTFESKFAMEEKRRRLLKLRIEMAKFLQESIKAGGLQVSDSVMDSDVFKEFYHKVRIGMHPTPEDVIKVAKLFDDDLTLDNLSRPQLVSICRYMQMTAFGTDNYLRFQVRHALTRIRQDDVVISDEGTDSMSYQELLSACQSRGVWTHNRTREQLKEGLDVWINLHIREKISGTLLILSRAFYFVGEPEDASTTYKDMQIKGLELTMSSLPDKLLNEAELHFSKEAATNKQRLDVLQEQEELIEDEAEQEEEVQAARNAEKSRKDAETVEASKIIPNASSKQNIDDARMTEEQLCELGEALSILSAKSSVLRERRELSELMKDLPPDETVEVSEPDGTSSSPKAKSLYRRIRSMLKRIDQQLEEFDKDVGGRMHLIEASSTGKISVDDLEQALRLIKHRPDEEVMHKLVDKLDVDHDGLVPLNDVLELAGKDSALANDGQVGDIKKESQKLRSKNHKKETL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT44</accession>
    <name>YTM1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">YTM1</name>
        <name type="ORF">MGL_0365</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732590.1">
        <property type="nucleotide sequence ID" value="XM_001732538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT44"/>
    <dbReference type="SMR" id="A8PT44"/>
    <dbReference type="FunCoup" id="A8PT44">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT44"/>
    <dbReference type="GeneID" id="5856896"/>
    <dbReference type="KEGG" id="mgl:MGL_0365"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0365"/>
    <dbReference type="InParanoid" id="A8PT44"/>
    <dbReference type="OMA" id="DHKYVEF"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000369593" description="Ribosome biogenesis protein YTM1">
        <location>
            <begin position="1"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="136"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="232"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="383"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="429"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="489"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ubiquitin-like (UBL) domain" evidence="1">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="528" mass="56122" checksum="F554342620B7572D" modified="2008-01-15" version="1">MSDRPDRVHDQAASSSRDSMTSTPSISSSNAPATVPIRLRTSLPGCSIPYVPYMVPVTWRRSQLSTLVNKVLATAQGAGHEEASYKAVPFDFIVDGSLLRCSLDEYLEQRGQSAETTLELEYIRSTLPPAFKDAARQDDWVSSVDARHAHRILTASYDGIVRIFDSESLATSPPQSYTPAYASNVSLTSAKWLRNTADAIVTGSMSGTVAVWRVPGTETKSVPVLQAAELEHHTSPVSSIDVAVAATNASAERATIVSAGWDGSIALWDVPADARFETQEETGGAPGKKRRKQHGSDARPISSAIITPPPLMVLHHVTPSLGATAARALNTAPTPGPNARTIAALGDGDQRIWSAAWDGTVKYWDVVAGGGLAGRKQTDKVPLCLDPLQSLSLSSFTTPQLVCGHMDHSLALYDFRDAVSNAALAMSGAHAAPVSAVKVHPVSAHLFASGAYDGRIKVWDVRSPKQALFALSEPVSTSSKSSHMASSKQPRTKVLGLDWTPDGNALVSGGEDCRVCLYQGQAIGIEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTB8</accession>
    <name>A8PTB8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endonuclease III homolog</fullName>
            <ecNumber evidence="12">3.2.2.-</ecNumber>
            <ecNumber evidence="12">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="12">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NTH1</name>
        <name evidence="19" type="ORF">MGL_0399</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="12"/>
    <dbReference type="EC" id="4.2.99.18" evidence="12"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732624.1">
        <property type="nucleotide sequence ID" value="XM_001732572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTB8"/>
    <dbReference type="STRING" id="425265.A8PTB8"/>
    <dbReference type="GeneID" id="5856930"/>
    <dbReference type="KEGG" id="mgl:MGL_0399"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0399"/>
    <dbReference type="InParanoid" id="A8PTB8"/>
    <dbReference type="OMA" id="IAMHRVH"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 15" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="18">
        <location>
            <begin position="33"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="HhH-GPD" evidence="17">
        <location>
            <begin position="435"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="13">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="13">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="13">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP45410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="663" mass="73965" checksum="3361208ACEF11D89" modified="2008-01-15" version="1">MSAATQTYEERAVKHTNACAKSLLETIARKQSNLCVSVDVTTKEDFLAVVDAVGPFVALIKTHIDILEDFDEDLIEKLAQLSVRDNFLIFEDRKFADIGNTVSLQYAAGVHRIVRWSHMTNAHLISGPGVISGLASVGLPWQRGLLLLAEMSTKGSLTTGAYTTANVQAAMQDESQFVFGFIAMHRVHEDPAHIPPDATPEQRAKDLLILTPGVGMDVQGDGKGQQYRTPQQVIKESGCDVMIVGRGIYGALLNSDAPRSEAIEQVKAQAQRYREAGWQAYLERVQPRNTQHLRRSRRGIRPLHTNTATVVAATASRAQDHQSSTPDMLSVKREATPPMLPLSQTRSSPVKKIKMELTEDEAQKIQVPRRWQEVYALLSKERQHIITPVDTMGCEENGQEDRRADRGRRRADGTEESDDDKARRLRFTTLVSLMLSSQTKDPVTADAVYKLQTRLPDGLTLVSLRDAPPEQITDCIAKVSFYRRKTDYLKTMTRILEEKHHGDVPQTVDELCEIPGVGPKMAFLQMQSMGLNVGIGVDTHVHRISNRLGWCKTKTPEQTRLALQSWLPRDLHGVINKQMVGFGQVICLPVSPRCDLCYIGQAKLCPSYRRVDPKTVGKRVPVYYVDGTVDRGDGRVPVDDQKTHENPTDAAIEAARKDKALEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTN8</accession>
    <name>A8PTN8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732679.1">
        <property type="nucleotide sequence ID" value="XM_001732627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTN8"/>
    <dbReference type="STRING" id="425265.A8PTN8"/>
    <dbReference type="GeneID" id="5856985"/>
    <dbReference type="KEGG" id="mgl:MGL_0454"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0454"/>
    <dbReference type="InParanoid" id="A8PTN8"/>
    <dbReference type="OMA" id="QHECERS"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14516">
        <property type="entry name" value="DSP_fungal_PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053239">
        <property type="entry name" value="Dual_spec_PTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047949">
        <property type="entry name" value="PPS1_DSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="480"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="553"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="696" mass="77807" checksum="5E0348D3348D1B8F" modified="2008-01-15" version="1">MSVVDDRVNAPAPVSAATLINNSVNVPKATDTAMSSSHTAAAALGIEFLPPTELRHLYARHLSHEVPANTVFPFLYCGRSGTPQQHVFLHGSTDLPPVPTHRGLTIVRAESHDTMPDHSVLLSSLRLQDLVDVHAPHGPRFLVPSKVGDSTGIRHFAAQSIHYAMISDIVVYGPDGMCDTVFDTARVLRDAQLEFFRERRTTNPHASKFRTYILPDPFTTLEIECPNLVAISSRGERRRLIDLFERENDELHFLTAPTAISKNVWVSTSDHVHPDTPSMSPAHRPFTINIEVYPHAVPPAASFLQSVTQSLRQFDASQGHGSPSRRVPRAQLECPNAVQQTKALPELALRILELCAWLHRQVHPDKCTAPQIPRHALMHCDDGYTEVSVLALAYLMYQHGLTLSDAYLYMHLHLERPFFVTPSDFQLLLLIEQRVPWMRRQSLSSKVATSPTALKSCSSAFSSSPASTMWIQSTHFDGSLPSRILPFLYLGTVFHAMNARLLEQLGITHVVSVGESAMQVKGPYTLQTAYYTGEVDVLEIEHVPDDGLHGLGEHLITAIQYIERARQQGGRVLVHCRFGVSRSATVVLAYVMAHMDWCFVDAFVFVRSRRLRILIQPHALFVWELCNWETYLARQKRTGHMSSPIDIGCGRHAYVLLPKFRHALGDFPVTWSYLCHHIAALHHAYVQRGAALSAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUP9</accession>
    <name>A8PUP9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732148.1">
        <property type="nucleotide sequence ID" value="XM_001732096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUP9"/>
    <dbReference type="STRING" id="425265.A8PUP9"/>
    <dbReference type="GeneID" id="5856454"/>
    <dbReference type="KEGG" id="mgl:MGL_0741"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0741"/>
    <dbReference type="InParanoid" id="A8PUP9"/>
    <dbReference type="OMA" id="PRILITW"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="85832" checksum="5712198D0256633F" modified="2008-01-15" version="1">MSWLKSAVGRSKSNAHERLPPLHSRLADWTGDFRDANKFAECFLDQLTLPGEISTMAYEPGMGYLAVGTSAGTVHLFGAPCIRMAITLRPALRVKHLLFKSDTYLLICIDEKDNLSIYDLSRRDPHGSTLHASRRTAPGQPQMANADTPMRVGIHSARNVVLCAEVTSVHSMLFLGLTDGSVETYDLERFSTTSFRIPNLWWNEEEILRRSQVPNAPSRLHTPLIIDIQTHPRDAAILLLCYEGGAILYSIRDNAALHTFQLRLLPGAPGPVPDAPMDVIWSERLCPATAIAWSPCGSMFAMGHENGAISFWSVKEEDKPIMVRTLDDIDIDRPVLPETLPKSSAGPREPIFKLTWSAFPEQGWYEYGAQAAGAWTSSAGASQNDKTASAGDGNGNGSGSGSGGNNTTGITSRTSPPNGTVLTIMGGTPVNQPATCLYTFHLSSPPATSGIFASQTPEALSRERAVLRDALQPFFVGMYRTASTVEDFCLLPRLNPHFRGTFDPYAIVILVGQDTMLPSLAVQSTRRGMDVFSFPPQQGTRAYERLSLPLPLTFAGRGTVLGAYVATVPVAQYRRLVQQATEHVVGSIKDNEPMGGLAKPQLHGALPIHAQALAQKGQPRILITWHLDGRVRWHDVSPHLLLLGDEDPRRGTILREPFPTPLPHLTVSIRDVVMHPSAIGMPALDALQRFPMQIQIASVHMAWDALECAISLTTGHVLHMALGTGTNINTSAVSPLIGSIQNMHMDSGAPSQHAFEFTSLETVADIHSGGLPAQCHDAASSWQCYVQCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV11</accession>
    <name>A8PV11_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP45007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732221.1">
        <property type="nucleotide sequence ID" value="XM_001732169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV11"/>
    <dbReference type="GeneID" id="5856527"/>
    <dbReference type="KEGG" id="mgl:MGL_0814"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0814"/>
    <dbReference type="InParanoid" id="A8PV11"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="393" mass="44131" checksum="913306D04BCE140A" modified="2008-01-15" version="1">MRTSSTAFDRNYQFDEAPEDRRTSRRISHRLSVEEREPETDQFVDAPEFPDEQIAIPRAKQTFHEQGGCDPIHKSEGLTRQAESFVPSKDSKQFDSQLFATNAQERSARMSKLTFSDVFQSTEEMFEDISVVRGALHLFLSSRMIEAYEIIEPRSERRLYYAVGFALLSSIKAIMTFEHQDLGTAISHCKDALHVASLLRKKASAFTSFGRFVRGSGASVSWLSSMTPLEKHAELSSSECTLVKAVLGIAYSGDFLGSLSEAFHLRAAYGEYRSLLKFIDWEDSNGGEKSDEDFRSGIYLGSGCISLILGLLPTRVLKVMEIFGYEGSVPVGLNLLSKSSGWSTDPSEPLPRRNIKTEGIRSPICDMSMLTYHLVISTFILYHKLTSTFRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVG3</accession>
    <name>A8PVG3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731588.1">
        <property type="nucleotide sequence ID" value="XM_001731536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVG3"/>
    <dbReference type="STRING" id="425265.A8PVG3"/>
    <dbReference type="GeneID" id="5855894"/>
    <dbReference type="KEGG" id="mgl:MGL_0856"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0856"/>
    <dbReference type="InParanoid" id="A8PVG3"/>
    <dbReference type="OMA" id="ESHYELF"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF147">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE OF THE SEVEN BETA-STRAND FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="434" mass="47601" checksum="8DE51C0EC870AA9D" modified="2008-01-15" version="1">MSEWANEARAALALPPTSALPRLRTEPTLASMESALRHVDILYGSAEQRPADLDDELLDELDAARADPTERSFVLDWLTRVVETELSWISDTHSRRAATEHAAQILSGCTSALDDGDIVREFTFPLQDETGVPPHIQTAQNTTVPSPSCASFSSVPGARMSVSVCVRDAPLPPSDAHSVQGAAQAADAVGVQTYASSVILCDLLVRCPSAWHQCLEVSSRPKSTWLNERAFRVMELGAGTGIVGMVAAHVVSHIFGQWTNACRPTVYVTDYHADVMKNLFYNVEHYLHVPEEHVDVQCMPLDWRALHDLVYPERAHGQSVACTPPAPQSISLLLVADPVYDPMHATWLIAAIVYLLALPDTDADARAHIVLPVRTAGRLAGLYATVDDALAAQDARHGFRLAKRQQMRLPRRPGLGRQDESEYIWTELAWRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVK4</accession>
    <name>A8PVK4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:38443"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
            <dbReference type="ChEBI" id="CHEBI:235323"/>
            <dbReference type="EC" id="2.3.1.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731626.1">
        <property type="nucleotide sequence ID" value="XM_001731574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVK4"/>
    <dbReference type="STRING" id="425265.A8PVK4"/>
    <dbReference type="GeneID" id="5855932"/>
    <dbReference type="KEGG" id="mgl:MGL_0894"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0894"/>
    <dbReference type="InParanoid" id="A8PVK4"/>
    <dbReference type="OMA" id="LMIKIHH"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="9">
        <location>
            <begin position="320"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="10">
        <location>
            <begin position="577"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="725" mass="83133" checksum="1DA9F2AC1260215B" modified="2008-01-15" version="1">MMSRRARRTAPAQTAHGSTPRRSRRSEFYDSTDVPTPRHARASELGGEHGMTPKTRRSRRPVLDDDDDAGDPVRRRSRRADLGGDTDAPLRPRRSRRSDASRNAAAVAPHAHRHQSRPSHGPRRKSMPRQEPTNRAFVSSSRTANLLEGSGRSAMDARSIETSGSTVFHDTIENHDVMMAAREPPRTNKTRHLAVPPRNQVNTMKEGRVFAMNGIDNLTLLMEDDTYQPACFSIYLFKTRLDYKTVRAFFEVLVQLYPKYRYVVDFEPYSAHRRDKRRRKQTAEDAERVHRERNEAMKRGNLPPNRGPRMMYSKTLRAGSWLRPAQWRIDEDFHVSENIEVISCEGHGTDEQLFKVAGRFLARHFDYNKPVWEALLVQGLDTADGGKSALMIKIHHCFSDGQGMIQSYHAALTAMSKGMGIKEVQQWVDTSKQKKKSQRKALKPSVFGTISHTCYTIRELYMRRRRSFVYRNMKMKRTPQRLYFHSDGISMDAIKRIREAYSTETMNLTLNDVAIAILARAMAQASRRLSPIGTSSDNRAAIFIPISVRPQGNWDLHNFTTGAMIWLKYPNLDETPVENMLADVHKEMMRLKKSHLPKIWYKLFLYWCRHRVGFLPNYPVTRQLFYRAFSEYHVATNVPGPTEPVKFGRHEAYSYHVLPPSSPGKATMAIGMISYAKDFSLAVSCDDVPEFRDVPHVLCKAFEEAAKVLIQAADHRLANRKESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVR4</accession>
    <name>A8PVR4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0936</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731668.1">
        <property type="nucleotide sequence ID" value="XM_001731616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVR4"/>
    <dbReference type="GeneID" id="5855973"/>
    <dbReference type="KEGG" id="mgl:MGL_0936"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0936"/>
    <dbReference type="InParanoid" id="A8PVR4"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KA1" evidence="10">
        <location>
            <begin position="526"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="580" mass="61863" checksum="0E7CA7C1B22DAE95" modified="2008-01-15" version="1">MLSAVTPATTTVAAPTETSFAASATSAAAPSAATSPVAAPPLVFPLRETQLTAAENMYDATKRSSWAPYSQGKAERTRPVSMPVPVTIPSQDAWASSSKPLPETQSRARPMSTTVAFGDAAGLTTVDSATPVVSSQSTVPTSAPAVTLTSPPTDVAGAPTTSLSTMPVLASQATPLPTVASSTVPATTTVVPASRASLDTSLERLHVLEKASSKPDTSGVSTTTVHPAQVDRNQTWWRQLGGSQPAAPTTATTPMTTAAAAGTTGTSATAATLAASAANASGPAPAERKSRVKSMDVERERPRIDAPLSLEEERLQWQRREAGRLEGERAERQRREAERLHQKELDHEYRQARERLEGQHQQKPVNTLEVALAMEKRLGVHSGPVDQAALTTRNPEEVFVDIIRVLQKMGIAVRQSKGEFSIECLRPKRLNALERLFSSRRHDDSRSKWMRFGSGKTSSGAGQQQASRVSMSDVERNMNRLSMGPGMTQTGTGGGPGGMMSTSATAQSLDSYSVANVPPEYGGSASGDGGHEVRFTVEMTRIVRLQGLYSVDIRRMKGNVWSYKYLYESLLERLDLGSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVY4</accession>
    <name>A8PVY4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731716.1">
        <property type="nucleotide sequence ID" value="XM_001731664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVY4"/>
    <dbReference type="FunCoup" id="A8PVY4">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVY4"/>
    <dbReference type="GeneID" id="5856021"/>
    <dbReference type="KEGG" id="mgl:MGL_0984"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0984"/>
    <dbReference type="InParanoid" id="A8PVY4"/>
    <dbReference type="OMA" id="AVRNCRW"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="9">
        <location>
            <begin position="89"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="250" mass="27768" checksum="BA091C2A53281CDB" modified="2008-01-15" version="1">MMPTPVARGRVVRPLGKEPEKCSSAESMEAASQSYAALMNQPVPPEPSLAPIPTAESIRHWIHAAIYEPDPARPYSIMKPPEDRPVRIYADGVYDLFHYAHALQLRQAKLSFPNVHLIVGVVSSTLCATHKNRPILESAERYEAVRNCRWVDEVIEDAPWVIDQAFMDKLQIDYVAHDEAPYAMASSGAASTDVYDWIKQAGKFLPTRRTEGISTSDLVARIVAIYRDGHLDAKLKKMGEDALVSTANAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW14</accession>
    <name>A8PW14_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731736.1">
        <property type="nucleotide sequence ID" value="XM_001731684.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PW14">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW14"/>
    <dbReference type="GeneID" id="5856041"/>
    <dbReference type="KEGG" id="mgl:MGL_1004"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1004"/>
    <dbReference type="InParanoid" id="A8PW14"/>
    <dbReference type="OMA" id="KAVFFCA"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="309"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="1276"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="1376"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1525"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="772"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1610" mass="178094" checksum="32087B3E9685EC96" modified="2008-01-15" version="1">MLHEPVLVTPLVGDGDVDAPLSTYANVDGDGFSHVLAQEKRSHDRVDAVWLCQDTLEYAIDRDPPASLHGVPVDLACVREWHVRMCPGTLMHPAHATLLDVFVKHHGGQEIQRGGSTSDSKRKGIECDETSPILTVPLLQGTSSWLLTCLALPIVHVDTRLSWSERRLVLRMDVLLSHACFAPHPPSTADQLRTIVEHANQLAGTFFLSHAHAIDELSGATLVYESLCRRERERSTQMPPAEQPRALLATLLPFQRRSVSFLLEREAPPSERRTLRTECGPWWIHAGNKAGLYFNVLTGEFTVDATAAVGVAGDVRGAILAEEMGLGKTIEVLALILEQADPHRHEKHEAYWDVQNEVCVQPIGTTLIVSPETLRRQWLDEVATYAPSLRLYSYTGHKQASEHRGRTETWGQWASQYDVMVVSFEVLARDLAASHAAPVRALRHPSRYERPRSPLVQLEFLRVVMDEVQLVGGNAAKTIGMIRRQRSLAVSGTPVRRLADLRTSLWFLGLVPPSMTTPRAWKRILSAELAPYVCELLANVGIRHTKAQVAHEMVLPPQTRFLVPVDFTHVETAFYRDVWQASLAALNLDADGAPMSDTWVLDTGILRSQLLRLRQACTHPQVAMRGGHVLGAADPSNASGGSASAGALGSVEAAGTSNVASGAINLRSIEHVLAQMIEASRLDLNTLKHALISRRIYRASILLFAPADELACNHLFSSSGKGSSEADEKKDIHSHDRFVAADATTMAPSPVTAATTALMEDVRTRDRRNVARDQLETLLAEAQAHVDALNEAIREAHVRGPWYVLTEAEQEQLAAYAQAADPSGPALPDAPIHEKLRLRQQYVGALKSRQRHWLQVLHRIQQFSGHCYFQLGQSITSKCGGEPAGEHLDNGLSNVNTGPSPSPYSALEDTAYQAAELTRQQLLADARMHVEQCASALQKQVVDVDQLAQVKMPSMTGLTGRAILDDVAERVHMLQAHAELILDWRAQIYARLMKPVNREVNKAREDDDVYAENLDAQIEAETLLEMYRPLLAQRDELLTGRIALGATARPQLFVELDRELRSARLRRFQVEHVDEGIGDAYDTDGKGKGDKDEFSEQVRQTKRLQLNHFRTLEEARRCVMLPPYAPPLSALLSAIRDVRDSSLHHEAQLLASMHAAVQTLLREQQRHLDALRREQMLCQALFNARAMYFKQVQELSDQVQDPVMPNGPWASISTSLAQERTLRQKIGATEGRLRYLGHVQLMQEASTKYRHQSGSTGGTGTGDADTDIDADEARRCFICTNLIETGILTNACGHLCCEACFHAWLSHGHRTCPMCKTRLAPRDVHRVVYRTATTWTGPSASSAYTSSNTFQVLPAEMRQALDNMALEGGSGSKLDLLIRHLVHIQCTTGEKSLVFSSFARGLDLVASNLERHGLAYARVDGTGGKRSSAAVHAFQHKPDVRVLLLHSEAQSAGLNLLAATHMFLLEPLLNHAMELQAIGRVHRIGQTRPTYVYGYMVRDTVEERIVALAAERKQSLYVCAHSHRERGDTTTTHDEHNHDGVDENRNDSDRMNAEAEDSALLQAAHDAAARNTTQEIRRGDLVGSTNDLLACLFPQHLGSAPMPPSMSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW23</accession>
    <name>A8PW23_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pseudouridine synthase I TruA alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731742.1">
        <property type="nucleotide sequence ID" value="XM_001731690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW23"/>
    <dbReference type="STRING" id="425265.A8PW23"/>
    <dbReference type="GeneID" id="5856047"/>
    <dbReference type="KEGG" id="mgl:MGL_1010"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1010"/>
    <dbReference type="InParanoid" id="A8PW23"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24315" checksum="9CB59DA5BE54704F" modified="2008-01-15" version="1">MSASPPALGDKRAHTPDDVRCAKLARLETDESGRSAGDRHGGDSAKEDAASGTGKEAGPSPTADTNDEGASTRLQKRKVALFFGYCGTDYSGLQVNPGVKTIEGDIFEAFCRAGAVSKENAVNPNKVQLQRAARTDRGVHAAGNLLTLKLILDPPNLPPNQTLTTYVNSLLPDQIRIWGMRRVQSAFNARTSCDSRLYEYLLPTYVFLPPKAMERNVEDAAPPQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWM2</accession>
    <name>A8PWM2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731881.1">
        <property type="nucleotide sequence ID" value="XM_001731829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWM2"/>
    <dbReference type="STRING" id="425265.A8PWM2"/>
    <dbReference type="ESTHER" id="malgo-a8pwm2">
        <property type="family name" value="abh_upf0017"/>
    </dbReference>
    <dbReference type="GeneID" id="5856186"/>
    <dbReference type="KEGG" id="mgl:MGL_1149"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1149"/>
    <dbReference type="InParanoid" id="A8PWM2"/>
    <dbReference type="OMA" id="LDWHGPH"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="45"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="512" mass="55640" checksum="C5CFAC41E772B228" modified="2008-01-15" version="1">MNTSNTDDITYKRKVMMVPDGGIVALDFAPVSMAEPSSTDSTPTVVILHGLTGGSNESYVRNAIAQLIKSREEGGAGVRCVVVNFRGCAQTPLTSPQLYSACKVTDLESALLLLTRMFPQSPMVGLGFSLGGSILTRYMGLTGKNTPLIGAIPVGAPFDLSKSSASLESTSLNRIYAKVLGSSLYKMAQRHADVLALSPDLWEPLELIFRTKIDPDASKPVAKPTFESPQYCTLRFVDHVMTRVAGGLPTPYGDFPFSSAEEYYKSSSPQNTLANIARPLLALSADDDPIVPLETLEAAITGVKKNQNLVLAHSQCGGHLGWFAGPRGERWIKHPITEFVCALCDAHAASKVNALGKGLGTGGPQASAWRWRSIDKRSVQVEVLPKSQVPSVLPQSLRAASEPDNELSNELVWLRSQVLPHLPLRHPNDSPAKRQDIPKGRMLSLTLVCTRICGYCGWHSFIRLTRDLPQHSDSIRPEVGFIELPDDVRVAVFIPSPRNTQIRQDCHIVSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWT9</accession>
    <name>A8PWT9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731947.1">
        <property type="nucleotide sequence ID" value="XM_001731895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWT9"/>
    <dbReference type="FunCoup" id="A8PWT9">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWT9"/>
    <dbReference type="GeneID" id="5856252"/>
    <dbReference type="KEGG" id="mgl:MGL_1215"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1215"/>
    <dbReference type="InParanoid" id="A8PWT9"/>
    <dbReference type="OMA" id="NTEEVRW"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25261" checksum="70F6094BD6379096" modified="2008-01-15" version="1">MSSTPSYEVYARWEKVLWRRQSFDDNYVDASFLGQLRINATAAFPTSVSLVLSSLSIGQQMASVFLFVALFVQLHMGWLHAAELVWTSLACSLLLAGAESTARKYSIRSIVRGAMSLTVLGFALHALSPVVRTFSEATTNDSVWACAAVLFVGHLAFANYSMRPDSGSRLTSTISLNMAMCASVVLSSRLMSDVDVFALLLVALQLFGIFPLLRDRMRVFESGARCCVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWU7</accession>
    <name>A8PWU7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1223</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731955.1">
        <property type="nucleotide sequence ID" value="XM_001731903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWU7"/>
    <dbReference type="STRING" id="425265.A8PWU7"/>
    <dbReference type="GeneID" id="5856260"/>
    <dbReference type="KEGG" id="mgl:MGL_1223"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1223"/>
    <dbReference type="InParanoid" id="A8PWU7"/>
    <dbReference type="OMA" id="RITRICC"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="66"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="203"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="384" mass="42620" checksum="8D29A4365081C76B" modified="2008-01-15" version="1">MKLNLSPGACIFEAGTGSGSFTHFLARTVARGPPAANGHGQTSNVWQTQRDSLTPAISNVHESEYEGRVYSFEFHAERVERARKEFAEHGLDTTVVLEHRNVCKDGFGLTNKADAVFLDLPAPWEAVPFAKEALRQDICTRICCFSPCIEQVLRTVSTLSEHGFTDVTTYESLVRTHESLTNVAPLDSISQVIERIRQAEAKRETRRQLQIANSKAERERRLQAQQTEGQCEYTSAEPDVRESVGETVAPQCDGANQGATSVSKASASLNLENQDIDTEGPPRLDSPRHGAPNPASHPAQKRKSDDLEQEDGDADQTQTTHAGEETSPNVYEQEPEAEILFSHGFRQKVERRPMQPANVYSRPYAQMRGHTSYLTFALLLPRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX24</accession>
    <name>A8PX24_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex subunit Exo70 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732032.1">
        <property type="nucleotide sequence ID" value="XM_001731980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX24"/>
    <dbReference type="STRING" id="425265.A8PX24"/>
    <dbReference type="GeneID" id="5856337"/>
    <dbReference type="KEGG" id="mgl:MGL_1300"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1300"/>
    <dbReference type="InParanoid" id="A8PX24"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="156" mass="17723" checksum="9C7AB8F9ECAF3B7D" modified="2008-01-15" version="1">MFVRILTITSNYTYVHVVLRNMVPSLGPIIMSMCESLLTQALRFARMSYLESWNIVVQSLQDGTSVPRPVPSQQRSMLSNPFLKFFEHLDMMDKVHRAHPLLHEMDLSKSICEDVTRIVSPLYGIVLAKLQGDLSLAQGSILSVPELERTIAQMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX30</accession>
    <name>A8PX30_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732038.1">
        <property type="nucleotide sequence ID" value="XM_001731986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX30"/>
    <dbReference type="STRING" id="425265.A8PX30"/>
    <dbReference type="GeneID" id="5856343"/>
    <dbReference type="KEGG" id="mgl:MGL_1306"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1306"/>
    <dbReference type="InParanoid" id="A8PX30"/>
    <dbReference type="OMA" id="DMIVPCL"/>
    <dbReference type="OrthoDB" id="2561385at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="720" mass="79803" checksum="F4F79FA128338788" modified="2008-01-15" version="1">MNKNELVLDSEKDASSPNVSTEKELSRLIINDGPFQPPSKSSVGTESTLSSATAEISDSLGGSTFQHSAELLWNQGGRGDASVHHDSKTKYNQFPLKSANLDTLSPMDHVSDAPWHYYFHSQLPVAYSFLESSEIIRQKLSGQLAAEKKLSQTPNPYDDSSAISTWSSCKKVPENTWADSHISSPHLSTTASSKVAPTENTLQNQKNEGTDRGQSTNVVNQSTYFGATKTHPNYDKKQTQPHSKVSESNKRPPLAQTGSSSSVSTFSDLASNAHNNQFGPGVRAKLNTVLPSLIQTIPLSGSRTIFITEYGCMNSRAVHLFRTIIEKFVTRVMEKELNDSSFQKKKQLEPQRASRNGFPEETADIVNFMVIHEDSNQSEMRSFQHMLETHPDSYLDPLWQSSHSPSLQHAIFSTLATRPFGSRIVPPDSLHLGFSLMDMHWTHAPTNNVSIASMAHAELTMSLNARAREFRRGGIFILAFVARSEVTAVDENGTKNSKSDVRSELGASAIEAKRVSNSPAAISEQDGSRLASIQGPIMEPNPRDIWATMSDMIVPCLQRLVSCGMMKVDVARQMLTLPMHPRSVSQTLRVLEKFNNVWSLDWSCGLGKSDLNEIVTDTGGVVTLQSEPNALRLPQPAWLALKAGKITHAAYHEHVIHMFKNLYEGHFRVVLRERGQLSKGAVEFILDSLWDVLRSRIDEPESFPLANCELEVQLLALRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX58</accession>
    <name>A8PX58_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">MGL_1334</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731151.1">
        <property type="nucleotide sequence ID" value="XM_001731099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX58"/>
    <dbReference type="FunCoup" id="A8PX58">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX58"/>
    <dbReference type="GeneID" id="5855458"/>
    <dbReference type="KEGG" id="mgl:MGL_1334"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1334"/>
    <dbReference type="InParanoid" id="A8PX58"/>
    <dbReference type="OMA" id="PHYYARA"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="24">
        <location>
            <begin position="422"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EDP43937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="765" mass="83896" checksum="C585321F70BBAA92" modified="2008-01-15" version="1">MYSPSPPAVAAASNPYVYINHQQPMSSAGQYGARTQPSGMGAMGLGPATSGSGGPLPSSSSGAGAYGHSPAIATLGSTRFGSSANLGWVSRQQQQSHFVSHFGTPPLSSIPPSMSQTYGSSMTPSSPSFTSLGSPHTMSMMKQTVSPVVPAPPTVSSSSTTSSANASPEWQQQLVCAEISRQSFSPHHHARAAALAARSSVSNGQDPKKGITLPAGIVANGLSLPLNKSSDETSRIRDESCGMSPTKSSFRTKETEGKEPGKSWSIIDMGGLKLKNIGIEVFRYTFLTSLFINHNNLTTISPAIVHLRNLTVLDASSNKLLALPAEIGMLTALRALFLFDNQLTILPPEMGTLYQLEMLGIEGNPLQSNLFDIIKQDGTQALIAYLRDSCPVPVPPPEREWVSLDVEAPSSGEDDSNTFAVLSYNVLCEKYATAQMYGYTPSWALAWNYRKEFILQEIVSYNAEVYCLQEVEMGQFNDYFEPKLKQHGYEGIFWPKSRARTMRDDERQHVDGCATFYKSDSFELVDKQLIEFNQIALQRPDFKRTEDIFNRVMTKDNVALIAMLENRTSGYKLIVANAHMHWDPEFRDVKLVQAAMLLEQLEVTGNRFAKMLPQVKLTQGRQPPKYSSGMQIPTLVCGDFNSTPDSGVYEFMSKGSAPGNHEDFMNHIYGTYTSEGLKHNYAMRSAYGNVGELPFTNLTPGFQGVIDYIWYTSNTLAASCLLGEVDRTYLSRVVGFPNAHFPSDHVCILAEFKVKPLENETTHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXB1</accession>
    <name>A8PXB1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731204.1">
        <property type="nucleotide sequence ID" value="XM_001731152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXB1"/>
    <dbReference type="FunCoup" id="A8PXB1">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXB1"/>
    <dbReference type="GeneID" id="5855511"/>
    <dbReference type="KEGG" id="mgl:MGL_1387"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1387"/>
    <dbReference type="InParanoid" id="A8PXB1"/>
    <dbReference type="OMA" id="QFVKELW"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="260" mass="29972" checksum="B78C2DA0E89B84C3" modified="2008-01-15" version="1">MPARGVSMEQDSRFKNKEDILLKTTKFPSILSERVDASKINMSVMRPWIAMRVEQMMGFDDDILVELVVSLLEADQFPDARKMQISLTGFLEQRAAPFMNELWRLLLSAQESVGGVPRAFVEQKKREMQATREQTSSVMSEFRRRQAPSASPGSSFQAHERRWDRGRSPIERRNSDAERSSSSLSRPSSWRHRAAPPSLRERDHGWGSRARMRRHSERDSESRCAEERDDFGRARRREESPEYSPPPARSRSASPGHDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXB7</accession>
    <name>A8PXB7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731210.1">
        <property type="nucleotide sequence ID" value="XM_001731158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXB7"/>
    <dbReference type="GeneID" id="5855517"/>
    <dbReference type="KEGG" id="mgl:MGL_1393"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1393"/>
    <dbReference type="InParanoid" id="A8PXB7"/>
    <dbReference type="OMA" id="WAREVMS"/>
    <dbReference type="OrthoDB" id="3358664at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="413" mass="43374" checksum="7BABDD2F817F24EE" modified="2008-01-15" version="1">MRKGGTSLSADASARQGKAVPVAPVDPAVQVAMMHAEFLLGQTRRNVEQLAATHALDPLLCRQLQTLLESAKIRPPPAPRSAPETQVAKKDTKKEVTGKNKWAREVMSDTSLLPTLVDTALSVTAGPILSSTQREAIVDIVGISQSRIANALTDPERQAAAQRWTQNTAKSAHQGLKGGLMGANDNWDKWYKKQLLDSDTRKERRKEERSLQEELRNERSQFHAPAYVGDTRSPSSDAAVSMTGLPVSKFSAITDNPATASVACLPSQQVADDSSLSTLTRAGAVTTTFSPWPGLVLTMSTVASSGSVDMPSTSGLDDQSGGRSLPPPPVPGQPTPPKPSISSQVAPPPPRRGPTGPTATSLPPLSPVQQPPPPHPASGVAASPLASQPLPPVPPPQYTTGSYGGVPSSLRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXL5</accession>
    <name>A8PXL5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731292.1">
        <property type="nucleotide sequence ID" value="XM_001731240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXL5"/>
    <dbReference type="STRING" id="425265.A8PXL5"/>
    <dbReference type="GeneID" id="5855599"/>
    <dbReference type="KEGG" id="mgl:MGL_1475"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1475"/>
    <dbReference type="InParanoid" id="A8PXL5"/>
    <dbReference type="OMA" id="WSQAGPN"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="7">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="6">
        <location>
            <begin position="118"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="693" mass="77691" checksum="E1570FF1ED90D3ED" modified="2008-01-15" version="1">MAPMATEQAHTLCTPRSPGPINQRMDMIHFSSFDVTDQVFFCSNDVAAIVNLKPVVPGHVLVIPRIPYKRLADMPPHAVGALFETVQKVGRVVEYAFSGDSLSIAVQDGASAGQTVSHVHVHVLPRRPRDIEPNDLVYDMLDKFGLELRDIHTGKQMDSERKPRTKTQMREEASWLKMQCDHVLGSEGDENDSHGKSTLPVTLLSGFLGSGKTTLLRHILTSPEHGLRIAVIINDMGELNIDAQLIANGQLIRGKDHLVELSNGCICCTLRADLLEHVALLARDKRIDYLLIESSGISEPMQVAETFSAEFAATAVEDERLAAIFQRGGLPAIAHLDTCCTVVDAASMLHDFDTSDFLVDRHGPTVPEGDDRNISDLMVDQLEFANCVIVNKCDLVSPDALETVMALVKMLNPSARVIPASYGRVDVNAILSTKSFSLEKAALSAGWLRSLVEDVKPETIEYGINSFVYRARRPFHPARLWETIRSCFVVIQEETMDDGVEQNRDDTEMSSNDDMNEDAQPALCPQQRLACKRASPLWNPVLRSKGFLWLATRPVMFGNWSQAGVMLTLTGGARWRCEVPENEWPDDPEVHAAIRRDFDPLTPWGDRRQELVFIGQDVDISKITKAMDSCLLRDDEWRQWEKIMRNKAMSMDEKHDALADLFEDGFEDWVDEEMVVEEHDQDHDHDHDTPKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY27</accession>
    <name>A8PY27_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1578</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731395.1">
        <property type="nucleotide sequence ID" value="XM_001731343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY27"/>
    <dbReference type="FunCoup" id="A8PY27">
        <property type="interactions" value="632"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY27"/>
    <dbReference type="GeneID" id="5855702"/>
    <dbReference type="KEGG" id="mgl:MGL_1578"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1578"/>
    <dbReference type="InParanoid" id="A8PY27"/>
    <dbReference type="OMA" id="KFIEWQF"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="60"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="216"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="824"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="12">
        <location>
            <begin position="975"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1111" mass="124627" checksum="4F88AF360B842083" modified="2008-01-15" version="1">MATKQATPAAGPIKLENTAKRDSLRALEQKYQDAWAATRVFDVDAPVNEPEMRDMTPEEVRAKYPKFFATIPYAYMNGSLHLGHAFTLSKVEFATGYERMCGKRALFPWAFHCTGMPIRAAADKLIREIEMFGDDFAGFEAAKAAEEADLQKKAQEEEAKAAEAGPQRVDKATKGKLAGKSTGLKYQFQIMENSGVPRDEIKKFADPTYWLRYFPPIAKRDCDAFGMRIDWRRAFLTTDVNPYYDSFVRWQINKLRKMEKIKFGERYTIYSITDGQPCMDHDRSDGEGLGPQEYTGLKMEVVQWSAEAAPLVDAKLQGKRVFFIAATLRPETMYGQTNCFVGPKIEYGAYKVNDTDVYICTERAARNFAYQGIFDERGRIECIVNVPGSALVGSQLKAPLGVHEQVYVVPMETVLSTKGTGVVTCVPSDSPDDYATLMELRKKAEFYKIDPQWVALDPVPVVQAPGYSDMIAADLVKQLKIQSPKDKNALTEAKEIAYKQGFYNGRMLQGSFKGEPVTEAKSKVQKEMINLGLAFPYAEPEGKIISRSGDDCIVALCDQWYLDYGEPAWKAQAEKLLAQMNTFQPETRNSFEGVLSWLHQWACARSYGLGSKLPWDPQFLVESLSDSTIYMAYYTVAYMLQGGVEDGSVVGPLGIKADDMTDEVWDYVLGGGEFPTNSPVPREKADLMRREFLYFYPMDLRSSGKDLINNHLTFCIYNHAALFPEELWPRGMRANGHLMLNGAKMSKSTGNSLSLRQAVEKFGADATRVSLADAGDGIEDANFEEKTANANILRLHTLIDWCTEMMQQVRENKLRTGALDSFWDKTFENEMNAAIVATHDAYERAAYKEASKLGFYEFQSARDLYREATSDVGMHADLVRRWIETQALLIAPIAPHFAEHVWSTILGHETSVHKALFPQPTKPEDAAMTAAAQYVRGTIKTIRDAEIAVTRRKAKGPAAPAKYEERKPKEVSIFVADAFPEWQDVCVNAVQKHYDGASGRVDDVKVREEVAAAGLLKDKKAMPFVMAFKKRIAEFGPEMAFNRQLPFDETETLKASSGYLKKTLNFRDVHIESAKDALTRADELQGKHGFDKHVVEGAEPGSPSFAFYNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYD9</accession>
    <name>A8PYD9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731460.1">
        <property type="nucleotide sequence ID" value="XM_001731408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYD9"/>
    <dbReference type="STRING" id="425265.A8PYD9"/>
    <dbReference type="GeneID" id="5855767"/>
    <dbReference type="KEGG" id="mgl:MGL_1643"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1643"/>
    <dbReference type="InParanoid" id="A8PYD9"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20026" checksum="E72F27B7A6D64C74" modified="2008-01-15" version="1">MMLVPSNRRRVEREMSTAMNDIAKSLMPPSAVPTIWELPAHGRDSTWVQAQLEALQRLGAHGEADGRDVYLDGQVSGTVYHGGEQLNQLLAASIERFLLTNPLHPEVFPGLRKMEAEVVSMVLQMYHAPVGAAGTTTSGGTESILMAVLAMREWGRAERGITRPEIVVPSSAHVAFDKAGAITLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYE3</accession>
    <name>A8PYE3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731462.1">
        <property type="nucleotide sequence ID" value="XM_001731410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYE3"/>
    <dbReference type="FunCoup" id="A8PYE3">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYE3"/>
    <dbReference type="GeneID" id="5855769"/>
    <dbReference type="KEGG" id="mgl:MGL_1645"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1645"/>
    <dbReference type="InParanoid" id="A8PYE3"/>
    <dbReference type="OMA" id="WPVIVCD"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05840">
        <property type="entry name" value="PWWP_ScIOC4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035503">
        <property type="entry name" value="IOC4-like_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF70">
        <property type="entry name" value="JIL-1 ANCHORING AND STABILIZING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="365" mass="40971" checksum="F1F2B42ED824BF56" modified="2008-01-15" version="1">MSAPHEFKIGDVVLAKIKGFPSWPGIIMDDENVPRAVLEERPSGKSSLHTIRFFPAADYHWASARDLKLLTNEDIDTFLEGSTRKSGDLLKAYKLAKDPHKWNAEQNRIVKEANDWLEEHGDEEEEEEEEEEEEEEDNESAEEDNDDDDNDSDKQGKKYGAKRSTKAGSKKRTASAKTSRRASSTKRARASEHESDDAKEADELVDGLEDRHKAGSASDASKTGNKEKATATTDAGADADADADADADKDAHSGKEHDASEELDPATRKVREWRHRLQRAFLNKGGVIVARDMDAQDATFKTVEAYTDMTVDQLKSTKIGKVMKRIQQLADIPRDDEFHFRERAGELMKKWSALLDAQTEEDKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ61</accession>
    <name>A8PZ61_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730892.1">
        <property type="nucleotide sequence ID" value="XM_001730840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ61"/>
    <dbReference type="FunCoup" id="A8PZ61">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZ61"/>
    <dbReference type="GeneID" id="5855199"/>
    <dbReference type="KEGG" id="mgl:MGL_1891"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1891"/>
    <dbReference type="InParanoid" id="A8PZ61"/>
    <dbReference type="OMA" id="DVMIHIN"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727149" description="Cation efflux protein transmembrane domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="305" mass="33762" checksum="71E2B0C1F39DFEDB" modified="2008-01-15" version="1">MLVNWAAAAWLQSFSLLAEASHALSDTLTDILTLVCLYKARQKPTTKYPLGYAKMEPLGSFFSSAMLLLTSVGIGAQALVHLATWLIPSHAWIGQLLSWTRIYHDDMHHHNHQHQSTSIIYAVISIVLSILVKEAVFRMLKNAAQSARSSVLEASALHQRMESLASAMSLVTIAATWLGYAWLDPIGGMIRAVYNGKDAWALLVESVDRLCDCSAGDEWTRRIEHALEQAAHCAVNTSDMPAFTWSELLVVTNGSALTVYVTLTLPPQITLQKALAAESFVREYIGTHHNEVRIFLRLHTRVGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZM8</accession>
    <name>A8PZM8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730934.1">
        <property type="nucleotide sequence ID" value="XM_001730882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZM8"/>
    <dbReference type="STRING" id="425265.A8PZM8"/>
    <dbReference type="GeneID" id="5855241"/>
    <dbReference type="KEGG" id="mgl:MGL_1933"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1933"/>
    <dbReference type="InParanoid" id="A8PZM8"/>
    <dbReference type="OMA" id="FKVMMQM"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="475" mass="52442" checksum="DBA31264A3E4FB09" modified="2008-01-15" version="1">MPSDSWRSKSIAQDVPYDDPKQLENVTKQLSSLPGLVTPAEIDRLHEQLARVADGKAFLLQCGDCAELFSYCNANQIEAKIKLILLMSLIIIYGARLPVVRVGRMAGQYAKPRSKPYETITLPSGETKEVLSFRGDVVNSAEVDHRSPDPERLLSAYFHAAATLNYTRGCLASGIADLHTPGTWRFHHVQSKSLQQEFERIADAISDALDFMKTVGADPTGDSNVLNTVDFFTSHESLILEFEHALTRDTPQGSYDLSAHTVWLGDRTRQPDGAHVEFARHVRNPIGVKVGPSMKPEELITLLDTVNPHVQKGHVTLITRYGESKVKDLLPEHIKAVQNSKHAKAVIWCCDPMHGNTVTSPSDPKLKTRMFSAVVSELTSCLQIHASLGSVMGGVHLELTGDEGVTECMGGSMELSDEDLKRCYLTHCDPRLNYEQSLDIAFLISDVLKSQRRGIPVNNALSQALLRSNRVEGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q016</accession>
    <name>A8Q016_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730972.1">
        <property type="nucleotide sequence ID" value="XM_001730920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q016"/>
    <dbReference type="STRING" id="425265.A8Q016"/>
    <dbReference type="GeneID" id="5855279"/>
    <dbReference type="KEGG" id="mgl:MGL_1971"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1971"/>
    <dbReference type="InParanoid" id="A8Q016"/>
    <dbReference type="OMA" id="FHECASI"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX-associated" evidence="3">
        <location>
            <begin position="177"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="446"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="914" mass="104570" checksum="A9F5909CE8F8F3D6" modified="2008-01-15" version="1">MPSGDPTLQNEPPTPAAAATAAARVKSDAQTGLAPARRMMLFRALPKIPTLRRDPVKMQRKFDAAQLRKQQKEQAQQRKREAAEKRKQERDKYAQKRKVAALVEQQKRDAEKARRQQAKKDAKQEAQYAKKAKASEAYMLLQRQQRQQELAEMDRKQKRLLAITPFQQRNATLDHHLLTPTQRHVLIRSLVMMQMQHEWLSLGQRGVIALYGYPFTKVQRSHRTSWAVPFSLFARQPQQARADDPLAAAENVTPSNEPLLLRHLFQTHVRTFPGLCSAPVSYWQSRIQRLIDDYVSLGLSTSRERGQHVLSHMLTLVGTQYIGLFFARGIGIRGADELRGPGIGEPGTEEWGVGKGWGSGTVKRGMAKPYVLSEKDHTLIESLYDGTDLRAWKAAGRESARIQHDWAAFKEKIIEQEDGLNEMTSYLTVSNVNNLPMELQNTEEWPAGTDSLLQRIISSAISRDVSTIQNHVVEPLRKELPNIVLVNKIELYVRDRTAEDAVRMDEDTDATGNDMLTTILLSNWDPFLDMDTQDHVLAMQKAFAASPYRTNLDLAYPSSTPQGRNKPPIPMWDATTVDMSNAREFALLKLLLRALLEKRDRTNLAKWFGSNVFVHFVKDSLQHVFYTGLQEASRSADLSARLADLQKLMEDFIEVRTNTDNGIEHWLGLSNRHHQSIYFFFHEIAPVLGPVWRWCQEALDFMSLSTSDPQHPDDRSAQDIEVNLDEMLQDQRLTEADVQDILREVDDMIVYSRWSKIRRELEYRRLFLLSQQHNHDGHDDSSMSGMSQAMREDMHDIDGLMAELLEKEGVPIDDGTCDDVRGTERRNMPWAYFDVVDPLGQAIMAEPETKHSFKPTRVSPRPPSLFHTRKLLPMFRELLVAELPDWLDPDLNGPPLPHAKQLRLSSLHALRQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q062</accession>
    <name>A8Q062_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S ribosomal subunit synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730988.1">
        <property type="nucleotide sequence ID" value="XM_001730936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q062"/>
    <dbReference type="FunCoup" id="A8Q062">
        <property type="interactions" value="745"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q062"/>
    <dbReference type="GeneID" id="5855295"/>
    <dbReference type="KEGG" id="mgl:MGL_1987"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1987"/>
    <dbReference type="InParanoid" id="A8Q062"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="8">
        <location>
            <begin position="298"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="542" mass="59308" checksum="71B6D7451DF6629D" modified="2008-01-15" version="1">MPGTPTHVLFESAVGLALFKVEQVESIGSQTKQVQEAMDDLPSFGKMVKLVSFSPFKSAPDALQGALDISEGIVNEHLKSLLTQNLRPEGKKVKGIGLGVCDRNLASSIVGELGIPCDTGETSQELVRGVRLHAEKLLKGMAEGDLARAQLGLGHSFSRSKVKFNVNRSDNMIIQAIALLDTLDKDVNTFAMRVREWYGWHFPELVRIVPDNITYARLARYIKAKENLGENDLEEMAEILQGDETAAHNVLDASRASMGTEIGELDMINIENFADRVVRLAEYRKNMHDYLVEKMHLVAPNLSALLGEVIGARLISHAGSLTNLAKYPASTVQILGAEKALFRALKTKGNTPKYGLIYHASAISRAAPKNKGRMSRFLANKISIACRIDCFSDAPSTKFGEVLHMQVEERLAFYETGKPTTKNSDAMRKAIAAMEEAAGDLMDVDGDDDDGEDHEDQDGSDDKDVEDNKDADDDEDSDDGPAEKEKKKKTSSKASSKAEKKKKKDKKSKSKASDVEKAAKKAAKKAAKEGKEGKDKKKKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1C1</accession>
    <name>A8Q1C1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730766.1">
        <property type="nucleotide sequence ID" value="XM_001730714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1C1"/>
    <dbReference type="GeneID" id="5855073"/>
    <dbReference type="KEGG" id="mgl:MGL_1765"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1765"/>
    <dbReference type="InParanoid" id="A8Q1C1"/>
    <dbReference type="OMA" id="NISHEKW"/>
    <dbReference type="OrthoDB" id="3259825at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="940" mass="102535" checksum="91AA4AD5E453912F" modified="2008-01-15" version="1">MLFSLYRGLAALLLAPNGEEISVTSIQNVLHMQRSSSENPKDVLNNRKFLTVGEELAVVQRLQQHLNHVHAGYDSIYGEGGTDGFGALDSSQTTWDVKIFKENVRRGVEQIVKTVLRSSLNYITLPGSGETPPSAENKTRTPSMYAVQSDTISRMVTVLEEAYFIITNEPSLISSHRSSFTTQANPAMNQSLSSHQAYPSLQARFPTGPPTNMDKDVRSKNVHFFSDGYQTNGGSYSMTTGAPLEGPTQSNAKTSNPTQDDAVQKTVMLTEALKPSKVLSRMDSKSGLRWTKTISRRKSKKALKRSISNPYLVTTTQNLDNAIDLGNLPIGHVPYDQVASGRLRSTSPILSNAQDINESSPMNSPSSRPGIPSYLLASSKDNSNTQSTPHVSFNSIDGNNARIAFASNPVPLSATLQPYTEKVPEFATTRGEESARSSADTRSLKISPSIRSKNQALPPLPSDGVSIPDSSHVSTIPETSITSIPAASSTPRRSSSYRVPVQYQTPESGGERSHQIPSPESSFSSARSPVGLTSLMNEQSRESLDSQEPKPEKPIATTLSPAVPRAQLLPWQTERSESPESNIQHRSIDSKSTVSPRRLDASSTHNRTPSKSSLAPSSLSASPTDPRYSHNSVVLTGNGMNDNSSNVDSISTVDPNTFPSPAKYEHHRSYANTSRISTVSTYIRESHNGDIITFPSATDQEIDQSDIMPGHFDAGDESGLKPGQRQSIPRKQVKPLKSHGDSLYDLYYSKTHDQDAQARRQPVTDNLKNEVHMGSRPVTGYGFTDAVKSKSRSPRIGSTSNPIWQVVAGLSDRTSIYSEMDPPNKRASGISVASRIPDSFNVGNRDMTSFSTDLEKRALFTEARSAKVDDVPMDNILIPSASEHIVHDRDDDLESLSSEGSDTEVHRQPSPVPQNAASEESEPLPSTQWHLKKRGIQLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1E8</accession>
    <name>A8Q1E8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730778.1">
        <property type="nucleotide sequence ID" value="XM_001730726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1E8"/>
    <dbReference type="STRING" id="425265.A8Q1E8"/>
    <dbReference type="GeneID" id="5855085"/>
    <dbReference type="KEGG" id="mgl:MGL_1777"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1777"/>
    <dbReference type="InParanoid" id="A8Q1E8"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="45"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="119" mass="13432" checksum="C20D9ACB71D511E5" modified="2008-01-15" version="1">MWERKKAQQEAMARGEVPSVLPTKRSSTARTQANQLPDEYVPPNRILFLQQMPATVTHEELTRIFGHLPNLYQVRTIPGRTDIAFVEFHDIPSSVAAREATNGYAFPTGEHLKVSFARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1F7</accession>
    <name>A8Q1F7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730782.1">
        <property type="nucleotide sequence ID" value="XM_001730730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1F7"/>
    <dbReference type="FunCoup" id="A8Q1F7">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1F7"/>
    <dbReference type="GeneID" id="5855089"/>
    <dbReference type="KEGG" id="mgl:MGL_1781"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1781"/>
    <dbReference type="InParanoid" id="A8Q1F7"/>
    <dbReference type="OMA" id="KQLWRQS"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="121" mass="13485" checksum="203A95A28171038D" modified="2008-01-15" version="1">MGVQVISSYDQFKQVTGGDKVVVIDFWATWCGPCKMIGPIFEKISETPAGEKIGFYKVDVDEQSQISSEVGIRAMPSFVFFKNGEKVETVVGADPSKLQVCIQSTRAWLWEETAPHRHGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2A7</accession>
    <name>A8Q2A7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730726.1">
        <property type="nucleotide sequence ID" value="XM_001730674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2A7"/>
    <dbReference type="FunCoup" id="A8Q2A7">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2A7"/>
    <dbReference type="GeneID" id="5855032"/>
    <dbReference type="KEGG" id="mgl:MGL_2180"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2180"/>
    <dbReference type="InParanoid" id="A8Q2A7"/>
    <dbReference type="OMA" id="ACLTHSL"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="285" mass="31262" checksum="56C6CDB9E7FAA8BB" modified="2008-01-15" version="1">MFCDLNVPWPVQAQSSAPSMSKKAKKLAQKAATSEDIVDEQQNALDALSPSEKKRISEITYELMEMGYTTVAYNYIVHTKYDPAIQKNPFSGTPPFPKLDPRTRKSYGVESYREGIKQLTRLTVVLDNDQAIKSGSGFVSANALALQRYDLLSVTPTTEMAFQHACITLSELKPFSVDIISLDLAVAPRLPFHLKRSTVGAALSNGVVFEITYGAAIDAKSSSLSSKSTSEMSDLSDARRNLFSGAREILRVTNGKGVILSSQAMDAMGLRAPYDVMNLYVRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2G2</accession>
    <name>A8Q2G2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="4">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730397.1">
        <property type="nucleotide sequence ID" value="XM_001730345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2G2"/>
    <dbReference type="FunCoup" id="A8Q2G2">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2G2"/>
    <dbReference type="GeneID" id="5854716"/>
    <dbReference type="KEGG" id="mgl:MGL_2192"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2192"/>
    <dbReference type="InParanoid" id="A8Q2G2"/>
    <dbReference type="OMA" id="VTLMGDN"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0385">Hypusine</keyword>
    <keyword evidence="2 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="5">
        <location>
            <begin position="41"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="114" mass="12698" checksum="4D87D7F85ABC4689" modified="2008-01-15" version="1">MSTSKTGKHGHAKVHLVAIDIFTGRKYEDISPSTHNMDVPNVTRREYQLINIDDGYLNLMSNDGTSKDDVKMPEGELGDQITNDFEDGKDLMVTIVAAMNEEHCLAYKEAPQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2S6</accession>
    <name>A8Q2S6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730433.1">
        <property type="nucleotide sequence ID" value="XM_001730381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2S6"/>
    <dbReference type="FunCoup" id="A8Q2S6">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2S6"/>
    <dbReference type="GeneID" id="5854740"/>
    <dbReference type="KEGG" id="mgl:MGL_2229"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2229"/>
    <dbReference type="InParanoid" id="A8Q2S6"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="118" mass="13284" checksum="3AB48DA08FC4213B" modified="2008-01-15" version="1">MSQNLTDEDQKELSTFLDAEQAKARVQSTVHAFTERCWDQCVKSSIGSHFGRGEEACLSNCVERFLDTSLFIVCVIERLTAGQKTREPARSERLSTHGQKKSARCMFDMSATMCMHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2U9</accession>
    <name>A8Q2U9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730443.1">
        <property type="nucleotide sequence ID" value="XM_001730391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2U9"/>
    <dbReference type="STRING" id="425265.A8Q2U9"/>
    <dbReference type="GeneID" id="5854750"/>
    <dbReference type="KEGG" id="mgl:MGL_2239"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2239"/>
    <dbReference type="InParanoid" id="A8Q2U9"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0137">Centromere</keyword>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="1" id="KW-0498">Mitosis</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="54" mass="6331" checksum="EB3E98F3636E78A2" modified="2008-01-15" version="1">MKALEDEKFDLAKNINDQESTLSMLESEIDELRRESEVVENWDVEEEVGMDRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q319</accession>
    <name>A8Q319_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730496.1">
        <property type="nucleotide sequence ID" value="XM_001730444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q319"/>
    <dbReference type="STRING" id="425265.A8Q319"/>
    <dbReference type="GeneID" id="5854803"/>
    <dbReference type="KEGG" id="mgl:MGL_2292"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2292"/>
    <dbReference type="InParanoid" id="A8Q319"/>
    <dbReference type="OMA" id="GQLTRNH"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="635" mass="70165" checksum="F860D952FE3C9DEE" modified="2008-01-15" version="1">MEAGSVVPEGSPAPRTPLAYIGPDLAAQAHVHMPPAVTHLLEQLMPVTPKILSSRPKQSTHASVWMDHWRPRCAAHVLGNEESALFLRDWLHDLRVSYSGARQRPIQTRTVSRKRGRPRSLMSGVSDMVDDPASDAADDAIVDAGYGNEDDEYKEFHPEEIAWFNQFRTDAPDPGPVATSLELSKLTNCIVLTGPTGVGKSAAVYACATELGFEVFELYAGMGRRSGKDLASAVGQLTRNHMVLGDARVRLHDMPHQSLILLDEVDVLFDDDAGFWPAVVELIGESRRPVVLTCNDLDAVPLAELPVQRVLTWEPAPAPVAATYLQLIALAEGYIVSNAAMHTLYTSTRLLADRLDPPSGPVSPMSNLFPSSYMMPHGHAYDLRAALAQLPWICLHTRAEDLLREMRSPKAGGMNESRNEHESTSAACESGCTDTASLTHSSSSINRARAELAALRTMYEAAETQSYADLVCHAREYTDEYVPLPARNRASVSRIPSVPCTSMHVPSDGSRLERSIQRALGVDETAHNSLTQRMDQDRLEHCQQLHTLLQLLHVPVQEQLPRTSIPLDYAPYVRVIHTMDMAHQQAWAAYLYNNQATLMRVTRNSMRLAPDVRAYQAWLPFGPAEREAAQRTSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3C8</accession>
    <name>A8Q3C8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730566.1">
        <property type="nucleotide sequence ID" value="XM_001730514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3C8"/>
    <dbReference type="GeneID" id="5854873"/>
    <dbReference type="KEGG" id="mgl:MGL_2362"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2362"/>
    <dbReference type="InParanoid" id="A8Q3C8"/>
    <dbReference type="OMA" id="LAFHQCM"/>
    <dbReference type="OrthoDB" id="2581252at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052848">
        <property type="entry name" value="CHCH_domain-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031731">
        <property type="entry name" value="CX9C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47106">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47106:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16860">
        <property type="entry name" value="CX9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMS import disulfide relay-system CHCH-CHCH-like Cx9C" evidence="1">
        <location>
            <begin position="5"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="105" mass="11558" checksum="2082135B310EA79A" modified="2008-01-15" version="1">MEPLMESVGKQCQDQLAVFQRCIYVHRNDPASCTQPQQELAKCASNAVPMLQTIKRTCGHLIREYDQCLAANKDASSDELAVQCTSKLRALAECAEAVKLNSQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3G4</accession>
    <name>A8Q3G4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730596.1">
        <property type="nucleotide sequence ID" value="XM_001730544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3G4"/>
    <dbReference type="STRING" id="425265.A8Q3G4"/>
    <dbReference type="GeneID" id="5854903"/>
    <dbReference type="KEGG" id="mgl:MGL_2392"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2392"/>
    <dbReference type="InParanoid" id="A8Q3G4"/>
    <dbReference type="OMA" id="RNEGYNW"/>
    <dbReference type="OrthoDB" id="42919at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="88" mass="10491" checksum="8A4C461E9E7FA035" modified="2008-01-15" version="1">MTCVHIVLFKVKAQVLKNGYEEFKARAETIRDLPIVKEHAKELQLGPPIWDTRSHGFNYGLYSVFETRESLERYKEDNDHKEYVYELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3G6</accession>
    <name>A8Q3G6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730598.1">
        <property type="nucleotide sequence ID" value="XM_001730546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3G6"/>
    <dbReference type="FunCoup" id="A8Q3G6">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3G6"/>
    <dbReference type="GeneID" id="5854905"/>
    <dbReference type="KEGG" id="mgl:MGL_2394"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2394"/>
    <dbReference type="InParanoid" id="A8Q3G6"/>
    <dbReference type="OMA" id="AEHKYAV"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="58622" checksum="012978A0552F9CC1" modified="2008-01-15" version="1">MRASEHKSRALSDPASFQHSYLHSRVLASFVCVILAAVPAWWALTTITRLSLPSEEVRAWEVRGTCPIRATWAVILEDAQPDLSLCERAQTQLQTHTDRHDLCLDWHVSAPNVCAAGEPLDHATRTFPVPLSAYENQGTAGIVEYLSSLFGGSSYQARADAINTSAIASASQHDDPRVVQYAPHIRIVFSLLQEDASLGNGFDGWDLTHALQDIKAHKALAPLAQTLEALERVYSVQLESQVQWYAPLESTPQPVHHPERMNETYYAVSMQDVSVFVNSVHWALDSYGTADLSPATEIRTLQMVLFVPSVQHSPLYIEGPDVGTVAEPAWLVPQWGGVVVWNPTQRVEGPPSTVLSLETLQKPMSRFTGQIRTLLGLHVEPLAMTEPEQQHALLQAAEGLEWRRTLEMTRSAVETLASIVRLVNKMPSLGVNAKVRDEFLASLHELAFCDSSRLDTLARATSAHTHASRAFYDPSMLVTLYFPNEHKFAVYTPLFGPMVLPLILAVIREWKVRKRQRAVKHRSLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3I9</accession>
    <name>A8Q3I9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purine nucleoside permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730621.1">
        <property type="nucleotide sequence ID" value="XM_001730569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3I9"/>
    <dbReference type="STRING" id="425265.A8Q3I9"/>
    <dbReference type="GeneID" id="5854928"/>
    <dbReference type="KEGG" id="mgl:MGL_2417"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2417"/>
    <dbReference type="InParanoid" id="A8Q3I9"/>
    <dbReference type="OMA" id="TMFEPER"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727970" description="Purine nucleoside permease" evidence="1">
        <location>
            <begin position="21"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25133" checksum="91C882B2137EFCD7" modified="2008-01-15" version="1">MRLGLFVGWLVWGLAGLVSAASLLAPKVLIVTMFEPERNAWLDNMPLSRNISVPGLSPLFPHVSCNHDGEVCLITTGEGEINAAASLSAVVYSLSFDLRKTYILMNGIAGISPDAGTLGSVGLARYAVQVGLQYGIDARQAPKNWTYSFWNYGTMKPGSYPRNFYGTEVFELNSSLRDRVFELVKNVKLKDTSAVKKYRSTYSQERAKAPPSVFKGDVTTSDLYFTGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3J0</accession>
    <name>A8Q3J0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730622.1">
        <property type="nucleotide sequence ID" value="XM_001730570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3J0"/>
    <dbReference type="GeneID" id="5854929"/>
    <dbReference type="KEGG" id="mgl:MGL_2418"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2418"/>
    <dbReference type="InParanoid" id="A8Q3J0"/>
    <dbReference type="OrthoDB" id="76038at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55897" checksum="F35B91E8C8A9EBF3" modified="2008-01-15" version="1">MSKHKWKQSKHKKYAQMVRALGPVVNERDRQDYHNPSAALFRDFTNELVDRFDLQPDIGPDGKVRPLQEWLAEENSELANASVTLLRADVSDIDYGLMHCECLDGSIDHEAEGFALTTTDGSHIAAKYVVSAVGTGDCPLIPTWVRNAYSQDTTTQRNSNKSSSGQELTSACPRDNLCHADPMQRLSRPSVDKYEEPSPESMGDGWAHSSAISAPQFTFPPPNVSAKIERGQSTTALVIGGGLTSAQLADLCVRRGFSRVILLLRGFMKVKPFDFSLDWVGKYANAQKMQFWQTEDPQSRMDMIHQGRSGGSINPVYAKVLLQRARDGQLEIRTHTEVEDAHWDPEKERWSLMLHRSSDARPDSQFMNHTQKAGTSVSCLADYVVVATGTDLGFRELPFMKTLRSKAHVPEVHGIPIVKEDLQYGPWPLFCLGAYSAIQIGPTAFNLGGIREGAERVATRIQDMEERNVHPEHLDPFKHRSSINSYVHFSYDRLDIDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3K3</accession>
    <name>A8Q3K3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730634.1">
        <property type="nucleotide sequence ID" value="XM_001730582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3K3"/>
    <dbReference type="STRING" id="425265.A8Q3K3"/>
    <dbReference type="GeneID" id="5854941"/>
    <dbReference type="KEGG" id="mgl:MGL_2430"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2430"/>
    <dbReference type="InParanoid" id="A8Q3K3"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="92462" checksum="7D884407FB4F4D23" modified="2008-01-15" version="1">MAPAPSLQYAPIKGVVQVALDEAFIDQPARLGLFSLCVIKRQSLWLIVLDHTGWSVYKVRRCYDRGCFDTHEQDISIPRDAFIAHRFNDVVCLATLSEYYLVNLETEELTPIALPISQTTTVGSARNRPSIVSMPAYDNELPCFLITSHSDHSTLGAFLRVDGEPSARLLEWPSHPRSVVSHFPYLFVLLRDNSLYIHNLYTLEIVEKVRINSSMEPRFLLHVPPLPGWLPRRPGVPSAQVLPSDAYPEIPSSSCVRWAPISVLFVCKHALHCIASRTPGSQALLALGSPRETSILRAPCDDEEVRAALQMLGVYHLKHARFEQAQAYLIAGLFPPAMLLCMWPTLFGGQYSYVCEAAAGLWASLAPTMDEHISQHVAWNYCPPMEDSDPVLDLLRQQLRCRARAMLLHVLQARRNDSPLVSTAVVQLALECDPKTSLESLKPFLSASKLDIVKALAIQHERYVLAMHVSAEHGAFSEALHLACQLWEHSFHDSVDTLSEDDMRTYAKHLSKLDLAKFCLWLARHDMPQLHRYIHLQWDALADDDANSIWEELLTISTPRAHAYMESIVLAGHHVTDAMRRVLVNRLVRASQRDITARKKLHVWLEYGPSLQIEPSLHDLPVMRATVLARNSQYGEALELLIDEAHDYDAAERVCEYGHVLPLYLARALVCEESLSLYTRLLPARVRNPSKEKRARLYETLLHLYLSRCQHGSEFHEPTMRLLNTCASQFDLLYVLSRVPPKWSVQSLSQFLQRSLQEQLHARRSMEMAKSLALKSSLNAHDTFWRMSRAMGGVVENEPSTYDRADVEMRPSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3K7</accession>
    <name>A8Q3K7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730638.1">
        <property type="nucleotide sequence ID" value="XM_001730586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3K7"/>
    <dbReference type="FunCoup" id="A8Q3K7">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3K7"/>
    <dbReference type="GeneID" id="5854945"/>
    <dbReference type="KEGG" id="mgl:MGL_2434"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2434"/>
    <dbReference type="InParanoid" id="A8Q3K7"/>
    <dbReference type="OMA" id="YALDDGW"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="471" mass="51838" checksum="43D021FB8AF82109" modified="2008-01-15" version="1">MALRAGLTSRQTSSQLSKSTQHYQARPDMSDLHTLQAGVLDECARGDVLAWSKRTLAAFEAFGMPRELIRKQALQPRPRTIVRATTHDVLRLCNDAQENVSRHLLVGEPGCGKSMYLLQAVAHALESGWAVLYVPRCIDLINSSSAYMYSPSFATYLQPDIAAHMLQALLKVNGEILRRIETEGIQVEGTTVPKGSLEQVVQRALAEDNAHLRQLSLEHVIRTLAAQKDVPFLVALDDIQAFFMTSKYRDPDFVPLEAYELAVPRALLELVLAPPKDKESGLQRGAVLTALSSTHAEFPPSTELLKALQASTSIPDAPVPWPRLFSTVSCRGSATRVPEPHAYSKVHDTHLAFAQASAFQPVDVGQRLDRTEAASLLDLLHRERAIWTVPNDEGVYWPKLVESHGKYCFPFEKSWRSTAHVVAYKIVAHSPSPSALTVHQPPIPPPDVSIAVSWLAPSLCALAHCASCLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q479</accession>
    <name>A8Q479_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein BMS1/TSR1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730126.1">
        <property type="nucleotide sequence ID" value="XM_001730074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q479"/>
    <dbReference type="STRING" id="425265.A8Q479"/>
    <dbReference type="GeneID" id="5854433"/>
    <dbReference type="KEGG" id="mgl:MGL_2508"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2508"/>
    <dbReference type="InParanoid" id="A8Q479"/>
    <dbReference type="OMA" id="WSASANK"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="206" mass="23138" checksum="AB1DD8B9577FE4EF" modified="2008-01-15" version="1">MYKYERFLPHGIGAAVGSIYAPVTFGGSNVPVVLLRMRSESKEFGYDDDGVSAEQTPHLVGAGSVLDVAPTRIIAKRIVLSGHPYKLHKKTATIRFMFFNADDVRYFAPITLRTKYGRTGHIRESLGTHGYFKAHFDGPLSQMGTWIAYRMQLYADEYHRYSAYEPIQGMCGMAGCVCVCAYRQRVYPRWTSLFTGSRDGMPLVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4A7</accession>
    <name>A8Q4A7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2517</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730135.1">
        <property type="nucleotide sequence ID" value="XM_001730083.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q4A7">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4A7"/>
    <dbReference type="GeneID" id="5854442"/>
    <dbReference type="KEGG" id="mgl:MGL_2517"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2517"/>
    <dbReference type="InParanoid" id="A8Q4A7"/>
    <dbReference type="OMA" id="WRESLYC"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="8">
        <location>
            <begin position="22"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="9">
        <location>
            <begin position="362"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="11">
        <location>
            <begin position="659"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="10">
        <location>
            <begin position="863"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="12">
        <location>
            <begin position="1035"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1194"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1286" mass="142820" checksum="B170C5B0CD1F53CC" modified="2008-01-15" version="1">MPCVADFRLLPDGGSTVDHVPALCIVCTGGDIVLLPVGGDEAAPADVVGCVDQGILAAAWSPEEDLLTIVTGGEKRLLIMTREFEVVSESILVTDTFGDDQPVNVGWGSKSTQFHGSEGKQAAMAAAQEPASGDPRGPLVPDDDGLPRISWRGDGSFFVISNAEPFSDTTALHRVLRVYTRSGTLSATSDRSVRGISHVLACRPTGNLIATSQRMGGDYAPGRQGRHDIVFFERNGLRHGEFSLREEHGACPDVLHGTAPLPPWSCEHQIKALAWNADGSVLAVHLQRGSDHVLQLWTSGNYHWYLKHESVYEGMLNHLSWHPEQPWTLYVAAHGRVEKRTMWLETACSRGPPPHDAACAAVVDGHALYLTPFRRENVPPPMCSVAIFDSPDTHAHAPPETPIHVAWTTDVDADGNTSDLVALLYSQGVVHVWRLPYGSLSAAQPRPRAPLLPECIRTLTVPRDTYPYQVALSSKSSSLTVAVLATDGDNAAVWMLSDSEESQPVRVTLDGHGPRRLVSVPSSAAFALHDDRGDVTRLAPTEPPTPLDPLLAFCPTLHVLDMDETLMPVGLAADSRLLAPDRVLAKDATSFTSTNGLLIWTTHSHEVKFLPLSALSTTPNIVQLSRRVERGSRIVTAVPSAMSLVLQIPRGNLETTYPRPMVLDVIRSKLDQCLFGDALRLSRAHRVDLNLLHDHNPTAFLSNVPEILHQVDNIDHLNLLLSNLRNEDVTQTLYKPWDPSSHTPVRDLDTKVNRICDVFLDAFQSADERRFLSCILTAHVRKVPPDYEGGLRVLLKYIDTDPPLAEEACKYIIFLVSADQLYKVALGMYDLSLALMIAQQSPRDPREYVPFLRDLRSKEPLEYQRFCIDDHLGHHAKALAWLARSGDESRMESAMAYMVQHKLYREGLKAFANDPERLREAYARFGDYLSSHQRAAEAATAYELAGRLIDAMNAYKEADQWQQALTLAQKTRMAGPELTHFMRSLAEQLEEQHKYEQAARVLLRLPDMEAGIELLCRAHAFVDAQYECAAHDRWDLMETHVAPGLLETQSSLLEEASEIEEQMTKQVRRLFELDAKRDEDPSAFYVSEDVQALNNVEVSSDMSQMTQFTRYTTATSVAPSMSTLSLGSKSRQRAKAKKEEKKKNAGKKGSVYEEGYLHESLQKLLQTRLGTLQKDTARLLPVLVMFGERHRLAAQELQQRLLALEQSARRAAADLEERYARQMQDRAETTQALAAQVTQLAHGPGAPSETASSTLSTLWRWRQMQEPKKAPTVSHESWKLHLLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4G5</accession>
    <name>A8Q4G5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730156.1">
        <property type="nucleotide sequence ID" value="XM_001730104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4G5"/>
    <dbReference type="STRING" id="425265.A8Q4G5"/>
    <dbReference type="GeneID" id="5854463"/>
    <dbReference type="KEGG" id="mgl:MGL_2538"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2538"/>
    <dbReference type="InParanoid" id="A8Q4G5"/>
    <dbReference type="OMA" id="WITAKEF"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="104"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="401" mass="44177" checksum="F2383712239F70EB" modified="2008-01-15" version="1">MTHFREPITLDLVLRSLDKVPFSKPFVVILPILALLWERRGQSLSSALLKLPSLSEWSTLLTTRHRWVFRMVIFIVLKELSKVCSRSASNLGVSKPDRPKWKKDVVVITGGSTGIGRDVVQHLSRKFGARIAVLDITEPTYAPAKYGAPDILYVRTDVTNKDEVAVAHSKIKDHFGNSPSIVVSCAGVALAGPILTTSSRTFSRTFDINALANVILAHEFLPYMVENNHGHFMVVASSASYFSLPLLGPYSMSKSAALAFYETLRAELRSVYKAHRVRTSVVTPTKVRTLLGHALKDSDNNFLTPVLEPIQVASAMVDTLDSGLGRAISQPMFTSLLPYVRALPEWFRGLLTTVGNTDSSVTAESIANSFEAGYGKNWSKEDFANVFGEMESMVRASAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Q1</accession>
    <name>A8Q4Q1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2602</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730220.1">
        <property type="nucleotide sequence ID" value="XM_001730168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Q1"/>
    <dbReference type="FunCoup" id="A8Q4Q1">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4Q1"/>
    <dbReference type="GeneID" id="5854525"/>
    <dbReference type="KEGG" id="mgl:MGL_2602"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2602"/>
    <dbReference type="InParanoid" id="A8Q4Q1"/>
    <dbReference type="OMA" id="KMINYRM"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="194" mass="20652" checksum="8954B19A63952654" modified="2008-01-15" version="1">MPPVKAKGGRMMALIDYRLRVTLNDGRQMTGQLLAFDTHMNLVLSNAEEFRRIKPKKKKTQKANKKQKVSHGDTAAGQAHIDEEEDDDDEPLPPVQEQKRTLGLIILRGETIISISVDAPPPESKRDMPVMAPGPGRGVPTGRGAAMGAVPMVRPPFGPPPGFGGPPPMGPPPGFGGPPPGFARPPPGFRPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4S4</accession>
    <name>A8Q4S4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730242.1">
        <property type="nucleotide sequence ID" value="XM_001730190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4S4"/>
    <dbReference type="GeneID" id="5854547"/>
    <dbReference type="KEGG" id="mgl:MGL_2624"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2624"/>
    <dbReference type="InParanoid" id="A8Q4S4"/>
    <dbReference type="OMA" id="NVDNEDP"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF17">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="718"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="794"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="89670" checksum="A21AB1F1252A2381" modified="2008-01-15" version="1">MHGALNNEHGEHGVNGSFDAALARQVPSRLTTGESSRNDELHLPSTGSAAADTAGSRMGSFSFKQRPRDVSTGLSSMRRWLGRESYRNSSTFSARYRGSGMPEGWEHPARYLNVSQITVPSILPAVQPVPQSTPIPMLPYTVLCLLIFGEFSSSGVAGPFLFFMLNDFQLGDESRVGFWAGILSSIFFFAQFLTSLMWSSVADKHGRKYVLQMSLIGNSLSLIAFGLAPNLQLAILFRLAQGFFNGAVGVARGAVRSLTDETNEGRAYAQMGFWWGMGGIVGPILGGVLEHPAIKFPWLFGRSAFLHAHPYALPCMFAASSTILGAILSFFLESDAPTATGRIRLMSDHEVGHEHEHETDPNRSAWSLASSTWSRSRRSHHWPQAFGPRTRPISSGSAYGYQGEPARAHRESMLRRMSVVSSAAHPSSYFAVPHDAGHHDVPHAELDHENANPRASLVERFVLANDDTVLSITDLWVAAAANTEDVPEDDDRNTIAEADEAEEEDDEGQHHSDAEHSAPADLPTTSSSETRPTSTLSSTYVPPMHFTRSNKLHRMNGHDTSAAYRRPSSAVNAAEADEDVNSHAQSGALDSVDSTTADVSAPNVSPSPIWLLPLVVIGHYGVLSFHSSMFDQVFMAFLVTPEPSGGLGLTASHYAGLIAAMTFCQLLFQFQVYPNFGPPNGSLSHLAVLQWGVLLYLPCYVLFPFLRTFLLPNTDVAVMLGMILFAAIRWLANILSFTAVMVLLNAWTPAHLVPLANGLAQTMSSFARCVGPIIGGIIWAKSIEGGPNAHAWPFNFHFGFWVVGLVALAGAIHTRWMRDVIMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q530</accession>
    <name>A8Q530_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial Rho GTPase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">GTPase EF-hand protein of mitochondria 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MGL_2708</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730326.1">
        <property type="nucleotide sequence ID" value="XM_001730274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q530"/>
    <dbReference type="FunCoup" id="A8Q530">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q530"/>
    <dbReference type="GeneID" id="5854631"/>
    <dbReference type="KEGG" id="mgl:MGL_2708"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2708"/>
    <dbReference type="InParanoid" id="A8Q530"/>
    <dbReference type="OMA" id="HETTWGI"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="20">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="20">
        <location>
            <begin position="473"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP43112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="761" mass="83075" checksum="8CBA579976CE1FF1" modified="2008-01-15" version="1">MSHSHTEIRIVLAGDVGVGKSSLIMSLVKEGFVEHVQNVVPEITLPSEASPAGVTTKILDSGSGAAFQERLETELRRAHVVVLVYSVVDQESFERISSYWLPMMRSLGINVPVILVGNKVDQRPADIEEDALEDEIAPVMAEFKEVETCIECSASLTLNVGEIFFYAQKAVLYPTAPLYDSRSHTLKPACVDALRNIFHLCDSDKDGILSDEEINNFQFECFDAPLQLQELVGIKQLVMQGTHSDASMHLRDDGLTLAGFLYLHTLFIQRGRLETTWTVLWTFGYGMDLALTNTYVYPRFDVPHGMGVELSPLGYQFFTELFKAHDKDHDGALSASELEQLFQTAPGGQHPWGALNFPSGTVTDESGAVTLQGWLAQWSMTTLLEPRTTLAYLAYLGYPYFAHGMRASGSPPSSGTSSPCYVSAAPASYAWLDGTAVGNRSGCHARSALTTSALKLVRPRRLGERRRSHAEQCSVFLALVLGAHGSGKSALLRQLVGKPFRGKYAPTHRLQRAVAAVEQDGAERYLVLQEYGSHNEAEALRNPAKLERVSVIVFVYDSSDTHSFSYVSNLRQQYPHLASFPTLFVATKSDLDLARQRHEVQPDMYCRKLGLNIPHLGAGPLNVSAQLGEMAELYNIILSIAMDARGAVPAHGRSLGTVRLRWRTVALWLVAVSGSTAVLWTVWRLVFSSQTTAAVGLGSSGGTVNGSGSSSSHAARSWSLWWSSWWKTAPGVSSGNDVGFRSTPSATPSSASVTSILKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q535</accession>
    <name>A8Q535_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730330.1">
        <property type="nucleotide sequence ID" value="XM_001730278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q535"/>
    <dbReference type="GeneID" id="5854635"/>
    <dbReference type="KEGG" id="mgl:MGL_2712"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2712"/>
    <dbReference type="InParanoid" id="A8Q535"/>
    <dbReference type="OMA" id="LEWIHAC"/>
    <dbReference type="OrthoDB" id="10261563at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="239" mass="26911" checksum="A0118A4F715008E6" modified="2008-01-15" version="1">MGKRLRRRSSKKARAQTDADVDGAGSTAPQKDELDHASKHDSGEYEHQESVNDEVVHTTSAHEASTESEPALEQVHHNDADHEPDVAVAGDMKKKRKRSRKRKRSNVPHPGPDTEFIEDLSDSAKKAIAYTQQYLCDKEAWKFSKQRQNWLLRHVLWSPRIYELGRQLTEVPQEEIDEQEKLLIPPSLPLPDNGSWIADEYVSVVAFYLASMMGLAKQVPNVACVGICDKSSFGPNNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q547</accession>
    <name>A8Q547_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730339.1">
        <property type="nucleotide sequence ID" value="XM_001730287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q547"/>
    <dbReference type="STRING" id="425265.A8Q547"/>
    <dbReference type="GeneID" id="5854644"/>
    <dbReference type="KEGG" id="mgl:MGL_2721"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2721"/>
    <dbReference type="InParanoid" id="A8Q547"/>
    <dbReference type="OMA" id="AGPKWFG"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="150"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="238" mass="25408" checksum="301F32ADF9C3DE1A" modified="2008-01-15" version="1">MYEDEEALIAASCKAYQTVSQLAGSSNTSSAPFNDGSDLIVLDEADPSSTPAPNTVHSETGHSAKRLGKRRESNVLIHNTSLDALEQFGGFSAPRKPTKREIRELRAKDAGPKWFGMPGFPGSASHHKNTDARVEGGRGSFTGGDARAATEKEMRRQVTAIRLRNALDPKRFYRGSGGTGSDGSMPAYAQLGKIVGGGLEPSSMLTRKQRSDSVVGELIRDSASVSYSKRKFGEACGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q594</accession>
    <name>A8Q594_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730374.1">
        <property type="nucleotide sequence ID" value="XM_001730322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q594"/>
    <dbReference type="STRING" id="425265.A8Q594"/>
    <dbReference type="GeneID" id="5854679"/>
    <dbReference type="KEGG" id="mgl:MGL_2756"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2756"/>
    <dbReference type="InParanoid" id="A8Q594"/>
    <dbReference type="OMA" id="CHRKCHE"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF14">
        <property type="entry name" value="PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="REM-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="396"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="464"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="58869" checksum="E4FA409F69D89A25" modified="2008-01-15" version="1">MNQPSLSASALTTSSAASPNPDPDTSATASYLADEFSKRSPSDASVPPSAMFPIDSSAAYRTGAFTNGAVMAPGSDPAALTRVSTAARRNYTPLDLMKYDTPLTSAKVQRMISQLEYKLQLERQFKHGYDKIARLYQAESDRRSQGDAMNQRTESAGKLVLIQQALKRYQQLDMRDDEEVQQENPYAARRAHKPQSGTLSIAIKGAKEVDHAAISSSTRSMRESYVSIKVEESERVRTPASRSDAWNVSYELPLENTNEVELVIFDRVGTSAPVPVGLLWLRISDIIEQLRKIKAGQVGADGLPSASPSPMTPNSSDWVTADTMASMTSSLFPAQPTAQQAAKSGLEGWFTVEPRGAVYLQLGFTKQNVPKRSYDTGLGRHGAMRKRRDQVSVVNGHRFVPRQFYQVIRCALCGELLLNAAGSQCEDCNYRCHRKCAPKIVTKCIGTKSGASANDEVELKHRIPHRFEPFTNLGANWCCHCGTMLPLGRRASRKCSECDLTCHADCVHLVPDFCGMSMEMANQMLSNIASIKKPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5M2</accession>
    <name>A8Q5M2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729808.1">
        <property type="nucleotide sequence ID" value="XM_001729756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5M2"/>
    <dbReference type="FunCoup" id="A8Q5M2">
        <property type="interactions" value="531"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5M2"/>
    <dbReference type="GeneID" id="5854115"/>
    <dbReference type="KEGG" id="mgl:MGL_2794"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2794"/>
    <dbReference type="InParanoid" id="A8Q5M2"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002454">
        <property type="entry name" value="Chromosome 10, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="195"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="543"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="766" mass="85716" checksum="41CBBBA568CC88FA" modified="2008-01-15" version="1">MAAAVLLKEALPSLDEPIVTYLDRYIQDAGEDPSVDVMRDVVHPMLESAVICEPHDSANRKALPALLEKLGAMVAERVPTVLSRNDRGLTRLDKVVDMGAVEMSSTITYDAGNDSMDLALGRSSRNRTTVDVKKLEKQEAKTRAKLAKRAQRDLYESSKLVENAKKMASYEEMYMQVNPLESISSGAAKGKNKDIHLPNIDVSFGSNRILSNAELTMAYGRRYGLVGRNGVGKSTLLRHMALRDVPIPTNVSLLYVEQEIVGDDTPAVDAVLKADVWREKLIAEERRLNAQLQSLEEAANAAVVAADEKESEEGLSRGSAVDLPTRQRENQRDELSSRLGDVQAKLVDMEADTGPSRAATLLNGLGIVGADQRKPTKAFSGGWRMRLALARALFCKPDLLMLDEPSNMLDLNAIAWLEDYLVNEWEGTLFVVSHDRAFLNQVATDIVHMHSERLDYYKGNFDQFYETRDERRRNQLREYEANQQKRAHLQAFIDRWRYNAARAAQAQSRIKELERLPVLEPPEKESGEHFTLPEAEKISPPLLQLDNVTFGYSKDKILLRNINFDVTMDSRIALIGSNGAGKSTLIRLLINQLSPLSGDAKRNSRLRIGYFSQHHIDQLDLTQNPVAFLAARFPGRTEQEYRQHLGSFGITGTTGLQRIATLSGGQKSRVAFAQLSLLKPHVLLLDEPTNHLDIEALDALMDAINRWNGGVIVVSHDERFINSCLKEMWVCDNGTVYKFDGNVSEYKRVIVESNKRKLEEAARTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5M5</accession>
    <name>A8Q5M5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729809.1">
        <property type="nucleotide sequence ID" value="XM_001729757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5M5"/>
    <dbReference type="FunCoup" id="A8Q5M5">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5M5"/>
    <dbReference type="GeneID" id="5854116"/>
    <dbReference type="KEGG" id="mgl:MGL_2795"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2795"/>
    <dbReference type="InParanoid" id="A8Q5M5"/>
    <dbReference type="OMA" id="SSYMHAA"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="212"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="599" mass="68155" checksum="C34817931D62068B" modified="2008-01-15" version="1">METIAKALYASVSFKKVPGTLILHPNGVLEWNPSSSTSSVRGFRVPDIGLKGIQVSKPGAAQVALRIIANDQTTINGDSSALLVFSADADTAGKHRETFKERLAAAIAKTRVDQQQPPTQTGTATAHTAARMQNGTKAGREVNEVTLRGRVLRSNPQLLALHKEVVGSGTLSDADFWAHPTRATLLRAERAQMEQQAGRRGQLADPHPTQNEAGELKINITPQLIRDLFEQYPVLTRAYDENVPSRLDENTFWMRYFQSKLYHRLRTSLRSAASEQHLPSDDIFDKYLEAEDDGLEPRQPRNPHDALLNLASTEEDHTATGNIQDWTMRPGFDRRTLPLVRRFNKHAESLLTSSLGTLDERDARRVRRKTGGVDEEYEAGSEQQRKDRNLARDRSDIPWESHYEKDIVIPDLTERQSKAGRRLIIHDPHMYQAPDTNEEKSEEAEQTRFDYQRFRDDMAQWRLDLRKYVPSGATMDKTLRHMLENMKRQKEQRTSRALDELSADVYKRIVSCHAATSEFLQQFWQAVLPSMDHKHVDMEERVDKARYMLKILRRTDTRIEDIATAADSSLPGEGYDIVMDAFRTTREAVKMALTYAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5N2</accession>
    <name>A8Q5N2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FFD box profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2797</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729811.1">
        <property type="nucleotide sequence ID" value="XM_001729759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5N2"/>
    <dbReference type="FunCoup" id="A8Q5N2">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5N2"/>
    <dbReference type="GeneID" id="5854118"/>
    <dbReference type="KEGG" id="mgl:MGL_2797"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2797"/>
    <dbReference type="InParanoid" id="A8Q5N2"/>
    <dbReference type="OMA" id="WYPPPGH"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="12"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="50229" checksum="4087EBD3A1C95C32" modified="2008-01-15" version="1">MASPAAPSAGSSQDDSAASFIGALISLTSHSNIRYQGILSNIDAAQATLSLEKVHSWGTEGRCAAVGNPQDEVPKNDQVYDYIVFRAADVVDLRIDDPSPKSAPSQDPSSQPTMAPAASSMAGAPGPAHAELQGMVHNPYAPVGPYGPMYASMPQMYGMMPDAYPYSGYMPHSYVGGPMYASGQDMNFGLPPPHMHGMPLHQPTMYDTSTDLTQHSSLYPQSTSASVPSTVSAPPSVPPTSNTSKEPGTNAAQSRSTNDNSTKPSQLDKQALPNEKSILSERTSTPSLSASSKPESGSAPSLTTTSATTTSSAAQDNKNPKASGNLSDDAISIPNKSAGASAPSQDTSAPPAEFDFEKANALFRKESGSGSLGSDESGRMTSIPPASKSSFYDKKTGFFDNISSEIKDRLHGNDRTGRSALAEENERNILTFGDQAANFRGSNYRGRGRGRGRGRGRGRGGRGGKGTGGGHGRSENLPAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5N5</accession>
    <name>A8Q5N5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729812.1">
        <property type="nucleotide sequence ID" value="XM_001729760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5N5"/>
    <dbReference type="STRING" id="425265.A8Q5N5"/>
    <dbReference type="GeneID" id="5854119"/>
    <dbReference type="KEGG" id="mgl:MGL_2798"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2798"/>
    <dbReference type="InParanoid" id="A8Q5N5"/>
    <dbReference type="OMA" id="FIQCMIL"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="70373" checksum="054BE48375B78854" modified="2008-01-15" version="1">MTDNSMSVGEWTPNLWHMSAPKPTPVLSSEPSQPSLGLAGISNVQPNNPLWMTPDSFQTSQEPFMEMPFKNNIGVNIPFNSSNNNTGDNEASPGISDMSINNCAVLDTPVHNVTSVGPTNAHLNGTFAFSSPGQDLSLLTKPVNVQETSMKHESSAPTSPASPSTPSFTQAKAAVRETRSSSITTDFSTKQLLDFCLSHDMNKSSLLPHRSASVSSVSGVELGNSEDILCICILDPSGSVAYRAKNSYYPTLEALYHVETHEIELPGGSHMLASSTNKSGTKEMPDMFPLHSRSWEGSDYFKLGCEASSLLKVSAVNTLIHTAMNDLETFLPFIQPYEIEECVTNLVKARSASSWSPLQVRQKTSLLLLLCALGSSLRLSVSVPMDSKRNHSTALPWEFGHRCFLLARGLLCPRQLKLQSEEMTMEFIQCMILVHMYMIRCNDREASWSPLAYGGMALKHACQTMHINQSDVLFTQSMLRWEMTKRCMWVLYIQEATSRIEGYLVSPRCLWTYAPLSIELPVYLHGIFTPEGRADDAITSECMNRFNSQIELCQIFVRALQMKLHENAPVSQEQKNAAVSLQNQLTEWALKTPCLAHVTAESDTPALPSKKWAGSEALDSSNVYVLCSYLLSQATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5P9</accession>
    <name>A8Q5P9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729817.1">
        <property type="nucleotide sequence ID" value="XM_001729765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5P9"/>
    <dbReference type="FunCoup" id="A8Q5P9">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5P9"/>
    <dbReference type="GeneID" id="5854124"/>
    <dbReference type="KEGG" id="mgl:MGL_2803"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2803"/>
    <dbReference type="InParanoid" id="A8Q5P9"/>
    <dbReference type="OMA" id="YPFTEHV"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="588" mass="68685" checksum="BD49D736E79E1486" modified="2008-01-15" version="1">MNELLFEAYRVQSVNYGLDALFSAYANHIRDNGLIVSSGRTTTTVIPLVNGRGFLDNAKRLSWGGIPATDFLLRLMQLKYPNCPQRMTPYEVQCMLEELCYTSSDYDADLRAMHDPDTLARVDRVVQLPYSGPERKEKTQEELDKIAERKRAAGKRLLEQTKLMRQEKAQRNENDLRYYTLLSEWKEKESPEAYQARLESEGFETEHEFEKLLKRLDTSVRKHRAEEQGEEFEEEKKEPEFPLVDVPDAELDEEGIKEKRRQRLLKAGHEARLRARAEKEEEKRLQAEEEARETKERTDDPQAWLHKIRTQHRDSIARIDERKRLREMLPNRKSAAAQQRMRSITALASEHESASSGSQRRRKRGDDEDTFGADDNDWSVYRAINDATNEEEEAQDQETLAELERKLLEFDDEFTEESTYEAIQARKTRLTYTFLRGQEPRWDPDDPVQFHQVHMNVERIRVPEISWQPIIAGVDQAGVGELSRHVLFSVDQNIRDRMIRNVLVTGRYSSLPGFDARLSSTLQSYLPPHAPLSVRRAKNARFDPWRGMRQWVTEQNEDFRSSSVSKAEYEEKGSGWFKEHALSACWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q682</accession>
    <name>A8Q682_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <shortName evidence="11">DHOdehase</shortName>
            <ecNumber evidence="4 11">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2878</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="4 11"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729892.1">
        <property type="nucleotide sequence ID" value="XM_001729840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q682"/>
    <dbReference type="FunCoup" id="A8Q682">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q682"/>
    <dbReference type="GeneID" id="5854199"/>
    <dbReference type="KEGG" id="mgl:MGL_2878"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2878"/>
    <dbReference type="InParanoid" id="A8Q682"/>
    <dbReference type="OMA" id="GPYADMI"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="13">
        <location>
            <begin position="115"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="612"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="665" mass="71434" checksum="97B427FD0DC1DD60" modified="2008-01-15" version="1">MVFRTVATRSPLAPACHVARAYVKPKTQLNVRAMSMRARPSTPRRVVSGLVTVTAIVAGAAFGVYCLDSRAGVHRWLFPPMMELLTDPESGSKISIKLLEHGLAPRDCGKDDEVLRTELFGKTLTNPIGLAAGFDKQGEAIDGLFDLGFGLVEIGSITPEPQPGNPTPRMFRLPLDAAVINRMGFNSEGHEAVRERLHARLHKWVQRVLSAGEGLVSSVGAPAPEPTALAEAQVFANYPVINTSLLDDAHVPRSLKQDRLLSINLGKNKSSREDSVVDYVKGVQALGAYADMLVINVSSPNTPGLRRLQRRSVLEGVLRDVVTARDDVAKQRIDSLPLVVKVAPDLSDAELEDVADAARASKIDGIIVSNTTVSRPAGLLSTQHVHEAGGLSGPPVKPLALHALQVIYKRSEGKIPLIGCGGIMTAEDALEFARAGASAVQLYTALAYRGPGLPRRIKDDLAARLRAEGKTWKDIVGSGLRDVPSYAPDAVNQVGLYPGAQDAFDRSVASVRHEIEQLRESFEGHASEERRALPFDIDEHDDRFKELLREAHRVTDDVPHFNDASSPQAGVLPQRTSSVPEHLLLMAKERGLTQGEVLHEAVHDAAAVPQAPAPALAASHSADATPMSTDKAAPDHTTLGGLKGHEAKSVPEAYRAPSTAEKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6E1</accession>
    <name>A8Q6E1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729951.1">
        <property type="nucleotide sequence ID" value="XM_001729899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6E1"/>
    <dbReference type="STRING" id="425265.A8Q6E1"/>
    <dbReference type="GeneID" id="5854258"/>
    <dbReference type="KEGG" id="mgl:MGL_2937"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2937"/>
    <dbReference type="InParanoid" id="A8Q6E1"/>
    <dbReference type="OMA" id="MAPWHAK"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="280" mass="31411" checksum="B23613793E06E6BB" modified="2008-01-15" version="1">MVSANSTALARWDAKLGFQKHVFVSSLARLLPDGGLIGKIDVIVERVYPVGYMEGTLTSRGTVQYGGPQYSEDEEAERHATWELRCAETRARFAAILPQLSKAAAWLDSRTTATVFQPGDSNDAHDAGAMGMLDMEKAHAYVRELETQADPFASVVQATESDSYTNAYLSAILHALHERVHVLSEPSSGEYTSALHERCPRRHIRAFRIVRVRDAWPTRRTSRRTAQLSVWGDTDVLEEGGRYEITQLVPTQGRSWRARECVADAFLSTTRDTRYIRRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6F1</accession>
    <name>A8Q6F1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_2947</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729961.1">
        <property type="nucleotide sequence ID" value="XM_001729909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6F1"/>
    <dbReference type="STRING" id="425265.A8Q6F1"/>
    <dbReference type="GeneID" id="5854268"/>
    <dbReference type="KEGG" id="mgl:MGL_2947"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2947"/>
    <dbReference type="InParanoid" id="A8Q6F1"/>
    <dbReference type="OMA" id="MRLGCNQ"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727995" description="3-hydroxyacyl-CoA dehydrogenase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="15">
        <location>
            <begin position="9"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="193"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP42747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32317" checksum="E73A12F27623A046" modified="2008-01-15" version="1">MLMQFCRFGAGLMGAGIAQVLAHVGQYNVTLTDVTDKAIANGQNIISKSLARIAKKKMADKSAEEQQSFVKSVVDSINVTTDAAKAVESTDLVIEAIIENMKIKRELFGFLDTKAPGDAIFASNTSSLSINEIASSTKRPELFGGFHAFNPVPQMKLIEVVRTSQTSEDTHKALTEVAKRMGKVPVSCIDSPGFIVNRLLVPYQLEAIRLVERGVASAEDVDTAMKLGAGYPMGPFELADLVGLDTLEHIAAGWRETVAGSEHVPANLVTESPMLTKLIEEGKLGRKTPEKGGFYQYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6I3</accession>
    <name>A8Q6I3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729989.1">
        <property type="nucleotide sequence ID" value="XM_001729937.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6I3"/>
    <dbReference type="GeneID" id="5854296"/>
    <dbReference type="KEGG" id="mgl:MGL_2975"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2975"/>
    <dbReference type="InParanoid" id="A8Q6I3"/>
    <dbReference type="OMA" id="WSINDEP"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="1">
        <location>
            <begin position="876"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="2041" mass="224911" checksum="88A7752697CAB7C7" modified="2008-01-15" version="1">MHHRLTLAASLYRELSYLMLYVSSSDWDLSFQRCESHPDSRVTIRLMECLHWRWPQLDRFLRAKHRDLPLLPRTLLSAYVVMIRRIVHKWALFHADERNAVCASEMPEAASLLFDGLYVLLDSPRRRVMIWPTLGVLVGLAPVAYAPTRMRRESHSKKWSYLDALYHHMSHPRLGPAAWFSTVLIHNLCALGKSASVPQAITSATSTRLCELLHLYRPEDARLAGLFLASLIVLGHTETAMDLIHSFLYARPSHAGVLVVAHALLKLLVRDLGAWRRKLYPPCAPVLRRTYRGIIRTWIATTKVDDMSIAVLHSILYLALLDPMAVLTLLPNESDAELRLPQTPTVAQLDAALQKDSRVSLILGFLHMPTTVVSLHAASLAALKRLSGGTPASAVLSRFPYVPSWVVEGPKAAFTDTSQILAILAPADLESARSASHHVLQAESEGAMLYWLVALHTALSRILRSHGSIKPTIGPTAVLYGLCMPNLSVVQQSLDVGIVLDQLADLPTPLPLLIKTRPNLSLICQVLSAVEPPNAMVVTAWTGLMRVLQHILPRYSHGRVSKSELTHMAHVLVAGAHVALHDAPESSEMPLVRTVADLLLYYSTLHDLAFILLEAVPTPVLPHIVSIVHEGLPRDTASLAAWLRLLHDIIPRVNVATLPSTMLRQLVDMLLVCARSAESSGSRRNVCQVAGLLAQCERVEVDCARAELVDCILPWALSDEALRKETLECVAPLTTRLTDDIAPIVLRLDSSSQSALSRRTARIVDRLICAASLDKDMDAGVRDMALGHEPSLAVTALEHVLRQNMDFLAREAVTLTVSPLSSARIAIMLAVSRLFTLPEFAALDSAAEVPQFDIADALFAEDGCWIARCISSGAISDAQLLERVLAGMMRIDKIHKILLALLDMEIDTCTGNAQWLRTNSSTLAFLSAYARRSAYVHTQSVVHRLAGVVASLPPDALDWDAAQSEDAQSMRLNEAMRLILIASDELIEFIRMLPAELHWLCEQVYSAVQVRFGADLAAHSLGTFLCLRVLGPAIAAPETIAVTMPKGDAARRALLFLNKVLVALPQGRFPAHREGTFTALNDLMMERGQVLVHVLHESSRHGQQHAQQLDVTTRILPQPVLRPLRRLMEERALHGDAHASTLLQLLPRSPSLHERIATALGGQSASTMLDFFLKTYSSGDLRGTSAIRTTICSDGRIILMLLYSKFDTVRADFVALAHMVLTTILQFKRPWSMLLDLTGATERQLLQTQFIVFVATLIPAPIFLALQSIIVVHAGTVVKRHGWSINDEPFHNCFLIRRENEGGPPLTFTWVTYADDIKALHPDIRASLPPSTTRLFTLKPKYIHSNISIDDGFCTPMPATLTLFEDVIVVRNKPLAISSHTATMRVCDVMPLADIYIRSDHVSRLCIQRLSSDDVLYISTLDCAELEHQLYTRCMALGAYAVGLYTPVSQQRIRAVFVGMGLFYRTSSDMPTRFAADTMLRAAGVIQDEMQPVFIPPNMPDLSSLRIQELLRAGALRSALGIATCLGREHVLFGYVDQLISAVCDMHLPQILHTVLLLWMLHPELRTALHSTLSVLHTLPYKATQAFLDVCIDLTPMSASPVLNSIQDTVLTAALPHLHDEIIAHLRNVLTCPQSPGLLHKMHALIALHSVQCLVPGTPVRKYMPDAMRIVLLFYQDVSMTFHTASYMTLFHVLAAWPAPSLAPLAREKLKPSMSLTALVELVNTIIFTLSTSVEECSHWTLTLERQIQAVAFASGSLMQSRALHVLGHLSNSSQAIMHSLGGVLMSSFPHVPSTSDAAAMCLSRVFLPQYAPILFWAGLVLITGGAYRGGLRLALTALDALGSDAFASIAQSRLQFPDDAAAFDTALGISFERDFSFACASVLRKPLWDGDSGIQKESRMLIERLNAIVPNEANDGENKDASGLSLLLFFMNPSDTALSAHPLPPQYDHLKDKTRSNNRILSVALARSFLPHASDAQLQAMLPLLTEADPHAPSKAHGDVFHDASPLSQLGFSGLKREGGSGQMITECRTWLQHIVQQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7L2</accession>
    <name>A8Q7L2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729538.1">
        <property type="nucleotide sequence ID" value="XM_001729486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7L2"/>
    <dbReference type="STRING" id="425265.A8Q7L2"/>
    <dbReference type="GeneID" id="5853844"/>
    <dbReference type="KEGG" id="mgl:MGL_3082"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3082"/>
    <dbReference type="InParanoid" id="A8Q7L2"/>
    <dbReference type="OMA" id="LRENEHE"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="203" mass="23198" checksum="9EA9766EE644D8CA" modified="2008-01-15" version="1">MRKELEDVTQELDGFEDLDPVDQEKVMAAFALGHVREKDMTPCLRENEHEHAEERKEVIDMGDATATSHDHSKNRASKKAGKKRGHPTNEENTSDDNDGASPPAYIEDLPPKRQRRRPQFYDPSRTDLSRRSTKQADMGAHAEGKKYMHSDENATHETAEDQEEEDDEEDEDEDEEDEDSDDSDIFEGDDDDDDDEDNDVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7Q7</accession>
    <name>A8Q7Q7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione peroxidase</fullName>
            <ecNumber evidence="2">1.11.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.9" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729550.1">
        <property type="nucleotide sequence ID" value="XM_001729498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7Q7"/>
    <dbReference type="FunCoup" id="A8Q7Q7">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7Q7"/>
    <dbReference type="GeneID" id="5853856"/>
    <dbReference type="KEGG" id="mgl:MGL_3094"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3094"/>
    <dbReference type="InParanoid" id="A8Q7Q7"/>
    <dbReference type="OMA" id="IYTSPLC"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="103" mass="11223" checksum="46ACC96075DFBF12" modified="2008-01-15" version="1">MVAKQIAEKLISENAIAIFSKSYCPFCKRAKEVISGLSVEPSKIGTLELDEVNDGPEIQNYLAEKTGQRTVPNIFISGKHVGGCDDLLRAQQSGELQQMVGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7V8</accession>
    <name>A8Q7V8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3138</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729594.1">
        <property type="nucleotide sequence ID" value="XM_001729542.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q7V8">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7V8"/>
    <dbReference type="GeneID" id="5853900"/>
    <dbReference type="KEGG" id="mgl:MGL_3138"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3138"/>
    <dbReference type="InParanoid" id="A8Q7V8"/>
    <dbReference type="OMA" id="PPCVDEN"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045801">
        <property type="entry name" value="MEKK4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19431">
        <property type="entry name" value="MEKK4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1027"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1319"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1332"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1362"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1056"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1428" mass="159115" checksum="D76B5D3825E392C9" modified="2008-01-15" version="1">MASGADAHAHARPQRSDAAESMGPPENADKDLAYLTSYMKRIRTDHAAPVETPAQLSTPQAERSVLDHVASEDDPKKRMEWQKMLRSVLESEVLSSETKRIAAADATTPTPTQLMHSVWLCVRALRVGHIHYRDEPESEEHLITEERDRLVPAVVADVLAFSKDTLPPSNDMRKQLFEAVQVLLERIEAVDELFPSQRQLLAGYPTWAQPHFQARLSALQAWFNVTRELRAQVQLLHRWTGTLTSSDGTLRPTMSPALPRVDTDEENTFVVERIFRESNIHEAFEQRTLKRLRMLIDMARTTLRQHHQMFLEMGLSSFEPDVLPLVRFPMWLAEGALRQRLEYADKLQEPSVLLVDSLADDLRAALALACRIKENYVQLTVPEPDIGWSLPLESDDKFDASICSALHFFFRLLYFRLKSTPYFKEVDVLEPEWDFLSSAVRVVPGGDVIVAHKTAALVNRVFARIIAYFKRELQVPTSSTAAPSAKMPLRSQATSASASGSTAKNRTSAEPASAGRVAGGRVPMNVLEMTRWIHTVFNNTRVRSRRLIGFARRMRLTLETAAEYDLRTLKTAKTQPNDLHGFLQTMLYADYFLVYTSAFEERGVFVLAEPSLHDKPLVIQDLIFQCVRPSASGADDTLGTSGVSVSLGHGPTTHFSARPPWQPQYLLFLTPREPFLWTGRVMTLPLPWIDLDLKENRVRLVADGAGARLEQCKQHWMWQFSMHATEGSAVPSVVGSPAATSTAAAAAATAAAAHLHGGTKNVNGGSSSSVPGYAFSLMPVYERMAHLSLIQHELKLMTKAGYVLTDTVVHAVPIIRRQMLKLRPLAPHDRAACDELVQACFSIAFDQGARALGYIQSVRLHSLMSTALVQLSVDWISFICDDCVLTERRTFKWAVEALENAMTRTMGENIFLLSEHEFFQLRGKVSSCMALLISHFDILGARSSAVKEQEEKRAKRAAHGTHLDLALDSEKEAKHLSEQRLVALDACDAAREDVMRERREIGHVLDDTRMEDRGLQLLASKGVQMRWQQGRFIGGGTFGTVYLAVNLDTGGLMAVKEIRFQELTSSPNLFKQIHDEMNVMEMLRHPNIVEYYGIEVHREKVYIFEEYCQGGSLAQLLEHGRIEDEIVLQVYALQMLDGLMYLHSQGVVHRDIKPDNILLDHMGVIKFVDFGAAKVLSRRSLSMHTGGRAPVHLPGAVDARGQSLQGTPMYMAPEVVRGETHGREGAADIWSLGCVVLECAKGTRPWSQLDNEWAIMFHIGMAQQCPALPDETQLSALGIDFIKQCLTIDPFKRPTAVELRQHAWICALVDVLNAENEAEEEAQRAAEEEAAESAVAASESALASSTDPATDESEQPGYTGHAPDDQRLTHSLDASRDDPARLAPGAHVPLSTNSPGYPDHSHPGHEALVADVQYRREGAQIKAMLEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q804</accession>
    <name>A8Q804_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729629.1">
        <property type="nucleotide sequence ID" value="XM_001729577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q804"/>
    <dbReference type="FunCoup" id="A8Q804">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q804"/>
    <dbReference type="GeneID" id="5853935"/>
    <dbReference type="KEGG" id="mgl:MGL_3173"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3173"/>
    <dbReference type="InParanoid" id="A8Q804"/>
    <dbReference type="OMA" id="ARAQMEM"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="267"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="310" mass="32227" checksum="4D24BDBB6AC0243C" modified="2008-01-15" version="1">MNPSNLHRTDTIHMVRAAIKSSGPSNTMPASSTSSKESATRAAESQGVPAGFSAGQQFMNNPLSALNRADYAGPHMASLLNEAGGMFGNFGGMNPRDPNVMMGMMQNPEFLQHMRDMLSRPEVIDQIIASNPQMQAMGPQVREMMRSEYFRDMITNPETIQRMTQLSQILGGGGGAGLGGAAPTWPPPGAFGAPTSQPSAGTDQNSSTSTTATNAANAGNPLASLAQLQQMLGGVGGAGTDPASMNPLAALASLGGAGTQAPTDSRPPEERYATQLEQLQNMGFFDARANLRALLMSGGSVEAALSILLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8B1</accession>
    <name>A8Q8B1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729694.1">
        <property type="nucleotide sequence ID" value="XM_001729642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8B1"/>
    <dbReference type="STRING" id="425265.A8Q8B1"/>
    <dbReference type="GeneID" id="5854000"/>
    <dbReference type="KEGG" id="mgl:MGL_3238"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3238"/>
    <dbReference type="InParanoid" id="A8Q8B1"/>
    <dbReference type="OMA" id="WHEYKTR"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="105"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="937" mass="104521" checksum="F11032ADCB93A1F1" modified="2008-01-15" version="1">MTERMATPGLRRLPPYWHEYKTRAKTRWYGRQILEVFTTEFRDRTKEYYIWAIHHGLCTVNGHPVTPTYQIQNNDFLVNRVHRHEPAVTNAPVRILHRDDSQGRIVVVKPGSIPVHATGRYHHHTLVEMVKEQAKLQNLYTSNRLDRLTSGIMVCSTTKEAACELGNDFNAGLVNKAYVCRVVGRFPDGIVDCTEPILSVDRQSGLNIVHPKGKECRTLFQRLSYDAATDSSVLVCRPITGRTHQIRVHAQWLGHAISNDPLYNHPVWATVDRDVLSTAQPRHYERVGGESGNVEVERVLTALKGQRDDSEGWARWRDQVLFGALNRQLGYEDIYVPGPNGQPAYRPSFCQAHDNDDDSNTKDNKGTDGAKDVEAAATATSDTCSVCHIPLLPDPAPGELFIYLHAIKYWTDSWVFEDELPWWACTTTWQNPDAPPQHERLPSLPLIEHHAGHDALGLGKGGAHRRVDASSSSAISPGISLGNIPYASRPQHNVSDREMPPVCVEVTRGLEDAVQRELLQCVPHTDTCCITTALHSGILKVDAPLHAHVLACYNADELPIAIALYFLMGHTTLPRVMLDALFAERVEALGKSGPQHEKNAPPTPSEHALLAWLEELWDAHAGDRIHALAAWKHHAAGTPPQTWCVVVDRSSYVFPTLSTAALESHISKLVTTWLDTEAVPALPAPRSQADMLIKCTFAPRYGVDESLVSGPRARQGNPSGTCFFQLHVPGTLAVSSSDALRTRIARARAHALSALLPIGDGRCRISTCNSTTPSFIEALEHMLRVRGREACVVRGAPKQAYSMQSMLVEMPERARDMPHAFLFDHYMAELEHIAQGLEPGGHALVLADEPKTLQRAVRELENRARREQHEHVLRWSPVTWLDTRAWPSEDARTLADARVESQMRGGWRSYMYHRTFLGMLVQAPLYDVSKATVSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8E2</accession>
    <name>A8Q8E2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729711.1">
        <property type="nucleotide sequence ID" value="XM_001729659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8E2"/>
    <dbReference type="STRING" id="425265.A8Q8E2"/>
    <dbReference type="GeneID" id="5854017"/>
    <dbReference type="KEGG" id="mgl:MGL_3255"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3255"/>
    <dbReference type="InParanoid" id="A8Q8E2"/>
    <dbReference type="OMA" id="EWVSHVA"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="678" mass="73610" checksum="C648908E273C4E82" modified="2008-01-15" version="1">MTYRVPDIYASSSSSPPWGIGAPSSSPPSSPTYIRSTSTASTVQVSDPFSASAKSLTISGPRSSKRWIRSATTPARTDRDNHTHEPDLHSLDLLPSDTHAAPGVLEQFFDDSADDAIASSSMDEFGSSFDMSQDQANAPLRTYRPFGRTDSASTDPLSATGRSESMQRAPQRLRLAGTSPKRLSRRDHGDLAPWERQEEEGGAMRAQSSRIQQLQPAWQNPLQWDAVVCRIFDEGRERPTLSLGGCGLTHIGSAVGDLRHYVTIDPRRSDHTTTHMSTQPRSWARSQSSSTGDSAELARRQVQFYLFDNQLTRLPSALFQLTNLGVLSLRKNQLTQLPPAIGELRHLRELNIGGNELTYLPAEIQQLHLDTFTYVPNPFRPVPAGAVLQTRALYGHMNVSPTHHSTQPLGPSASLRWSRAHTLATSVLDTGHGTHHGPRIHMARVLGRCEPQSRPSLAALCIQRLLSEEPLIIEQYETGCLRSLQHTLDVRVVAQLEAARRSATASWGAQVDVQASTGAGAGLAGTKREHAEERWYTGASFHGGDAVSVDGAVSSAAPGVSTVDVDSILEESDDACKNVWFNRCPGVGAHDLRGASGMKEDTDDSDWPIDDGKGPLYVHAAEQRMEWVSHVAGMRVAKQGIEMAGDSVRGMPAEHAGLLPILWRGCSPGCLAFLEQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8Y3</accession>
    <name>A8Q8Y3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729333.1">
        <property type="nucleotide sequence ID" value="XM_001729281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8Y3"/>
    <dbReference type="FunCoup" id="A8Q8Y3">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8Y3"/>
    <dbReference type="GeneID" id="5853640"/>
    <dbReference type="KEGG" id="mgl:MGL_3368"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3368"/>
    <dbReference type="InParanoid" id="A8Q8Y3"/>
    <dbReference type="OMA" id="MYSAREN"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="STI1" evidence="7">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="7">
        <location>
            <begin position="529"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="580" mass="64653" checksum="9BA263963976EE94" modified="2008-01-15" version="1">MSVAELKAQGNASFAAKDYEKAIQHYTAAIEAAKQSGESDAVHVLYSNRSASYAGMKNWDAALSDAEETIRLNSSFAKGYGRKGSALHGARRYEDAIAAYKTGLERCPDDTALKKGLADVERASADGLRGDPSASIGNLFRDPQLFDKLSRNPMTESMLQDPSFVQKLKDLQSGKSNPMAALQDQRMIQVMGALIGVDMKAFERPSSEGAQPMEEESMPKPTSASRKEETKKESQSEAKSEAETKPLDPNVAEAEKEKKLGNEHYMKRDFDVAAQHYQKAWELHQDITYLNNLGAVYFEKGELDECIKTCEKAVEEGRSMLADYKLVAKAFGRIGSAYLKKDDLEHAITFFEKSLTEHRTPEILNKLRQTEKEQKERARQAYIDPAKAEEERNRGNTLYKEGDFPGSVQAYTESIKRNPSDPRGYTNRASAYTKLAALPEALKDAEEAIKVDPKFVKAYIRKSNVLFSMKEFTKALEAANAANEVDETIEGGPQHKREIQPLLTKCMQALYDQRSGESDEQTLERAMRDPEVVGIMQDPVMQTILQQAQSNPAALQDHMKNPGIRAKIQKLIAAGIIRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q925</accession>
    <name>A8Q925_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729361.1">
        <property type="nucleotide sequence ID" value="XM_001729309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q925"/>
    <dbReference type="FunCoup" id="A8Q925">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="GeneID" id="5853668"/>
    <dbReference type="KEGG" id="mgl:MGL_3396"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3396"/>
    <dbReference type="InParanoid" id="A8Q925"/>
    <dbReference type="OMA" id="PAKYWDI"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="122"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="334" mass="38317" checksum="CB2DFA4553A3EE03" modified="2008-01-15" version="1">MNPSKTASSVAPVDGAESSAYDHTFGSRTLDEGDDVWSHNAWDHVVPPQEHTDMVEELLNKQAESRVCDDDAARYHAHASEYWDSFYSRHENRFFKDRQWLRIEFPELIAATRADAPPTTIVELGCGAGNTVFPLLSMNKNANLRLVACDYAPQAVQVVQNHPLYQNQSTCEAYVYDLSAGTQHARSTATEAERLPPNIEPESVDIVVLIFVLSALHPNEWKAAAENVYRMLKPRTGLVLLRDYGRHDLPQLRFKKNRLLDDNFYVRGDGTRVYFFTPEELMSIFNVAPRGQHKQERFEAQQMAIDRRLLVNRKERKQMFRVWMQAKFLKTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9C1</accession>
    <name>A8Q9C1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin-14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729419.1">
        <property type="nucleotide sequence ID" value="XM_001729367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9C1"/>
    <dbReference type="GeneID" id="5853726"/>
    <dbReference type="KEGG" id="mgl:MGL_3454"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3454"/>
    <dbReference type="InParanoid" id="A8Q9C1"/>
    <dbReference type="OMA" id="PYGAYQK"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="55476" checksum="9F101984264E27D4" modified="2008-01-15" version="1">MHAGDEDAHVRHAQAVRFLTSLRSSSKDTRIHLTPKHVDFLHSKGMSDDEIERARQDAERPDYTNMMHIFDDDQARIHASGDSAAFEQAADSFRAPLLGLTTTSDAPPIPPAASYPRSPLVLYSAADAPVPRRDATQILSDFAASMARPRYDTLVSYFRLLHLLLMLTGGGAAIVVAMYRKFLMPKIAAMIEARTSLLSLQLENFGKMLESLTCLRSTKLARLLPEDYKPTWTEQELDSKQVQKSESGQECGSNLGNNQDDHSVQDEKQREHTKHESSDGAMVNSSSNKQDSALSFCANRPKSEPEEPSQWHVSSVNDDETSEGENAHVSARIRPTRRRVLEPIDITHPLRESLSRLAQTLRNAHRSSTYDTIPSDTDEHGLLDLTPIPEADAASSGQSLPHSDGPSAGIRAFRKTLDQVRNELRASVLSDDEPMSLASHRFSAYTQASSSRPTSGPAVEIMQMKADIRSLKGLLLSRRNFPSFMRSARATSSLPSSTATSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9C6</accession>
    <name>A8Q9C6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3457</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729422.1">
        <property type="nucleotide sequence ID" value="XM_001729370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9C6"/>
    <dbReference type="STRING" id="425265.A8Q9C6"/>
    <dbReference type="GeneID" id="5853729"/>
    <dbReference type="KEGG" id="mgl:MGL_3457"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3457"/>
    <dbReference type="InParanoid" id="A8Q9C6"/>
    <dbReference type="OMA" id="VPYGTMH"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="11">
        <location>
            <begin position="9"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="12">
        <location>
            <begin position="141"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="296" mass="34490" checksum="A7D00394F8DFC9E5" modified="2008-01-15" version="1">MSDEIDRQSNDLHDTVLDGELVYETSEEGVNKTKLLLFDCLAINNENVTKLPFQWRYACLQNQVLPIIEAFLRRRTDIRSTLGFEPLLKPMSRAYDVAIVLQKMPNLQHRTDGLIFTCLHSPYTFGSNFKILKWKPPGYVTIDFLLRFKQNMSEKSTCRNTMDKMIEKPSLELHLRTNDNSHVYFDDIAIDDDEWTRWKQCGTCLDGRIVECAPIFVTSCTGKIRENWKIIRLREDKIVANHYSIITRTLESIHHGVSESKLVKSVPGIARNWFHPKRRAKRIRFESTMPSILPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9S6</accession>
    <name>A8Q9S6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729517.1">
        <property type="nucleotide sequence ID" value="XM_001729465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9S6"/>
    <dbReference type="GeneID" id="5853824"/>
    <dbReference type="KEGG" id="mgl:MGL_3552"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3552"/>
    <dbReference type="InParanoid" id="A8Q9S6"/>
    <dbReference type="OMA" id="PMVYISI"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41164" checksum="A45CE418835A09A6" modified="2008-01-15" version="1">MASSLNQDKWIGFMLAVSSSAAIGTSFIITKKGLMSAAEDSDGLASDRLSYLGNPIWWAGMATMVVGEVANFIAYTFAPPILVTPLGALSVLVGAVLASFVLKERLGRLGILGCALCLIGTIVIVVNAPEDKEIETVDEILSYAMRAPFLTYCVFVAAFSIFLIVRVVPRYGHQTPVIYLSICSLVGSISVMSVKAFGVALRLTFNGHNQLTHLSTYCFGLMVVLCILIQMNYFNRALDQFSTNVVNPIYYVMFTTSTIFASVLLFQGFNTSTAPVISLLGGFLVTFIGVYLLNINQQSDDPSMNLPSSLESGTRANYERLSHSHGAHQEAPDAFIFDQSEHDQDFAPHQQQQSYPLAQFHDKLNANPPELTSSTNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9S7</accession>
    <name>A8Q9S7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729518.1">
        <property type="nucleotide sequence ID" value="XM_001729466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9S7"/>
    <dbReference type="STRING" id="425265.A8Q9S7"/>
    <dbReference type="GeneID" id="5853825"/>
    <dbReference type="KEGG" id="mgl:MGL_3553"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3553"/>
    <dbReference type="InParanoid" id="A8Q9S7"/>
    <dbReference type="OMA" id="FETWIAL"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="302" mass="34361" checksum="1B48BE34BA0E9E47" modified="2008-01-15" version="1">MPESKAATAAGVEAEADAASQMPRPEAAKKHEASNMNKENKDSPAHATDHVPEHGLRVALPTSSAFEDYIVYPILFVTVLYHIIHFIPSTLLPATFRHAWWGYPSDLFLLSQAPTSVPTLVLRESLKPNGLLGQSTWIAQWRNTFGNDILEQLITRLSSVEGRVRMIPRCLQSHACQKLYLVLGTEPFLACAFCHTVQDFQMYKIYGLWRMYIAHAFVLSIATISPHGTLPRVMEHMSRRVQQKRVLSAVRTRVHWRMWAWIVLVLAFVLDVAAILYAEDLPLPSGRWEHVRLRDTNSHTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA30</accession>
    <name>A8QA30_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729124.1">
        <property type="nucleotide sequence ID" value="XM_001729072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA30"/>
    <dbReference type="FunCoup" id="A8QA30">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA30"/>
    <dbReference type="GeneID" id="5853430"/>
    <dbReference type="KEGG" id="mgl:MGL_3591"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3591"/>
    <dbReference type="InParanoid" id="A8QA30"/>
    <dbReference type="OMA" id="IYASHND"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="15726" checksum="A8D1A6BC4B318026" modified="2008-01-15" version="1">MAPKVRSDNQEVSLGPSVDDGKIVFGVAHIYASFNDTFVHVTDLTGKETIVRVTGGMKVKADRDESSPYAAMLAAQDCAARCKEVGINAVHIRLRATGGVGPKMPGPGGQSALRALARAGMRIGRIEDVTPIPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA44</accession>
    <name>A8QA44_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729136.1">
        <property type="nucleotide sequence ID" value="XM_001729084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA44"/>
    <dbReference type="STRING" id="425265.A8QA44"/>
    <dbReference type="GeneID" id="5853442"/>
    <dbReference type="KEGG" id="mgl:MGL_3603"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3603"/>
    <dbReference type="InParanoid" id="A8QA44"/>
    <dbReference type="OMA" id="RIHASHP"/>
    <dbReference type="OrthoDB" id="3350372at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="721" mass="78918" checksum="2C7BAC4AF6F11FCF" modified="2008-01-15" version="1">MGSGPTTLTIALVVGLCGGMLVITALGLLCGYFLRRHWMAKRHESFERARIHASHPVMVSKSATGFRPYVRPEHPVLHNIPVSLSQHPPSLAPGNPYKHIHPTHLRPSAASHCSAPNLALSSTETDNVRFPSIIPEHATQPATIAEGPGSPLRRTGTMSSKYKLGLSRPSMRNTSLRYSRLSHSMLSRLPSHFRSGRSSRCISLESGESLGMPENQIPMARRIQRKEQRFQYDSSSYSSSVATPEDGWNMPETDSIMPPPPAMLKSEQEHENDKLHERIKEWQEQSIVADAPESEDGHSHIAELPPSKWRTDKTRIARYGTPSSSYSSGSESLYSHTTLSDVINPYMRSNTPTSLMRIPSIRPHFMAETSLESWLGPSDPRVQVRRQRATPSPSPSSLFKEVPMGGLSAEAVAASGRTPSPWAPESNSVHSSHSHLVRGQDVQETPQRSSRALLPTTPPPTSAGMAEPTPSTEVQLYLHPVTTTQRQRISQAGSTSSRSSYPSSARLSVEFPQDWKHSSNGTMSTELTWVEEASPAVMSKDAEVDGFNPQQAHTPDQQQHDFHGTAQHDISAPALPVPLPRRDVSAATDVEAMGYAYDPTEPELAVYPPQTPQILRAMHTRRASNTSPESHVPCYPNTPRKSDVTQGGVPMLSSGSVRPNSPASTASSESVSTEHGSHHTRPFMSPSSLLASPMETIQAWFQVHGEKLGTRDTPLGPRAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA67</accession>
    <name>A8QA67_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729159.1">
        <property type="nucleotide sequence ID" value="XM_001729107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA67"/>
    <dbReference type="FunCoup" id="A8QA67">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA67"/>
    <dbReference type="GeneID" id="5853465"/>
    <dbReference type="KEGG" id="mgl:MGL_3626"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3626"/>
    <dbReference type="InParanoid" id="A8QA67"/>
    <dbReference type="OMA" id="KIFQWAA"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="79"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="670" mass="74104" checksum="3D7A8FD78B4532D2" modified="2008-01-15" version="1">MASVSVSKGEGHNGDVRRSSESPDKLLERPEANVNTMAELMQAARKRYGSKKNIAWRDVIREHTEEKVVSKKIGDEEVQETKKWTYFELSPYKYITLEEFFTMVDQFASGMAQLDLDFKTHFNIFASTAVNWQVVAQSCFRQGVTFCTAYDTLGPEGLHVSLEEPEVQGLFTNAAQLPVVEKVVDSTPLLRVIIYDGEADEKILQSIQQKLQGRSNAALIHFDEVMKLGRQTKTEPAKVSGKDVACIMYTSGSTGKPKGVILTHANLVATIASICTLMNPYIGVGDSLLAYLPLAHILEFVVECFLMYFGIGIGYGRVKTLTSASVRNCEGDLQAYRPTLMVGVPAVWELIRKGILSKVQQSGATKQKLFNWSMWAKDKEVPCLKQLADSVVFKSVRAQTGGRLRYALSGGAPISRETHQFLNTALVTIIQGYGMTESSAMCALLTPKFFQYGCVGCPMPSVEVRLIDVAEAGYFANGNPPQGEICIRGPSVTQGYYKRPEITKESITPDGWLLTGDVGQWNPDGTLCIIDRKKNLVKLSGGEYIAIERLESAYKASGVVSNICVVASSDAKQPMAVVFPREDALRSALRENGKDSLADKQLSDLCHEKEVSQMVLRDLNSLGKQSNFAAMELLQCVLLIPEELPLTAAQKVQRKEVEKKYHDLIKRVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAE7</accession>
    <name>A8QAE7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729239.1">
        <property type="nucleotide sequence ID" value="XM_001729187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAE7"/>
    <dbReference type="FunCoup" id="A8QAE7">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAE7"/>
    <dbReference type="GeneID" id="5853545"/>
    <dbReference type="KEGG" id="mgl:MGL_3706"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3706"/>
    <dbReference type="InParanoid" id="A8QAE7"/>
    <dbReference type="OMA" id="PRCTHYG"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="538" mass="58789" checksum="28C53A7D272EA225" modified="2008-01-15" version="1">MPVGSLTEVPLSGDTDMPVNALVANVHGTYYATTSKCTHYGLSLTKGILTDEGRLYCPFHGACYKVMTGDIEDAPALEPLKTFEVKVEDGKVYIFVDYEALNQSNWKPCKHSSSQSRSGPHTVFVGCGAVTLHAVQEMRRCGYEGRITVLTAEPYPTIDRPRLSKAYAPELKHALVRDESFWRETLDVDLRLSNYVYAIDTNMKRLSIRGGNTVIYDNLVLATGSVPRRLPIEGANAKGVYVLRSLDDAQSITKALKKRPSPELVIIGTGFIGLEMGIALAKHAKVTLLGQTHVPLEGPLGRSVGGGLQTAIMNERPLRFLNAVDVVRIETDMNNHVRGVVVQPRARGSPELFLNADLVLMSTGAKPATEFLRNSPSFPDLRADGSVEVDSALRVIGLQNVYAGGDIAAYPSDTGVVRIEHWNVACNHGRDIGRTLATGKLHPYRHVPVFWSGLTSPLRYAGTGVGYNQMHVDGEPDEAEFIAYYAKDDRVIGVATMWKDPMMVQAVALMRAGKMPKLSVIAAGLDIMTLTTRPTRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAF4</accession>
    <name>A8QAF4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin associated protein KTI12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729246.1">
        <property type="nucleotide sequence ID" value="XM_001729194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAF4"/>
    <dbReference type="FunCoup" id="A8QAF4">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAF4"/>
    <dbReference type="GeneID" id="5853552"/>
    <dbReference type="KEGG" id="mgl:MGL_3713"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3713"/>
    <dbReference type="InParanoid" id="A8QAF4"/>
    <dbReference type="OMA" id="WCAAREL"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23805" checksum="40F4DCCDB5680176" modified="2008-01-15" version="1">MALLVVTGLPCSGRTTRVQEIRANFESRLASSPTLSSVRVVQDADVHVDRHVYESQRTEGRARAAYLSAVRRALSTSAIVIADGGAGLNIKGSRYELWCAARELGLRCATLYVACTQDLCRAWNAKRRAHGEPCYTDACLDELMFRFEEPTPEARWHRPLFTTTSVGSADHPECLPTPLDAIWDAMTLAQVQPPKAVTAVLGTSRYHHTERTVGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAJ5</accession>
    <name>A8QAJ5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTP-binding protein rhoA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729287.1">
        <property type="nucleotide sequence ID" value="XM_001729235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAJ5"/>
    <dbReference type="FunCoup" id="A8QAJ5">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAJ5"/>
    <dbReference type="GeneID" id="5853593"/>
    <dbReference type="KEGG" id="mgl:MGL_3754"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3754"/>
    <dbReference type="InParanoid" id="A8QAJ5"/>
    <dbReference type="OMA" id="EVNHYIP"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21916" checksum="42A5BE8E03C8D18C" modified="2008-01-15" version="1">MTELRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGRHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAIDSPDSLDNVQEKWISEVLHFCQNLPIILVGCKKDLRRDPKIIEELRKTSQRPVTPEEGMAVASKIGAVRYLECSAKTGEGVREVFEHATRAALIQKPRGSRSGKSKCLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAL8</accession>
    <name>A8QAL8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728989.1">
        <property type="nucleotide sequence ID" value="XM_001728937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAL8"/>
    <dbReference type="STRING" id="425265.A8QAL8"/>
    <dbReference type="GeneID" id="5853296"/>
    <dbReference type="KEGG" id="mgl:MGL_3777"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3777"/>
    <dbReference type="InParanoid" id="A8QAL8"/>
    <dbReference type="OMA" id="SRGMNRQ"/>
    <dbReference type="OrthoDB" id="4087970at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="137" mass="15432" checksum="854BBE26A7A3D554" modified="2008-01-15" version="1">MAKSLRSHSKLAARNRKRYTPDSDYAVTAAARLQQVSERLKQRIHTPKVSEQNGTQEGDSIEEDVIDTEAQYDPSRAEETSSMTMPAQGDMQVEAPAPKKISTSQPRGTRNGQLRGSRSQKMQRHKSRNAGKPKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAS2</accession>
    <name>A8QAS2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729032.1">
        <property type="nucleotide sequence ID" value="XM_001728980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAS2"/>
    <dbReference type="FunCoup" id="A8QAS2">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAS2"/>
    <dbReference type="GeneID" id="5853339"/>
    <dbReference type="KEGG" id="mgl:MGL_3820"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3820"/>
    <dbReference type="InParanoid" id="A8QAS2"/>
    <dbReference type="OMA" id="PADMHLH"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="7">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="354" mass="38891" checksum="21EA616E4CED730A" modified="2008-01-15" version="1">MVVDSRLYDVLGVAPDASTDEIKKAYKRQSLANHPDKNPGDETASQRFQEVANAYETLSDLDARAAYDKYGEDGGPGFPGGGVDMDDVLASMFGASGFGMGPRAPRRAQDSVIPYDVTLEDLYNGKTAHFSLEKNVVCSHCHGTGGKPGTVQKDCVTCGGKGRLLQQRHAGNGLISQTMATCSDCNGKGKKYREKDQCKKCRGRCVVGAKAKLRLDIPRGGYDEQRIVFEGEGDQLPDTKPASIIFELHQKPHSTFQVRNLDLLANVTITLSEALTGFSRTILTHLDGRHIHVTQKRGQVIRPGQVDVIRGEGMMDQRYYDRKGDLFIQWNIEFPTDEWASSVDAKVRACLCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAV2</accession>
    <name>A8QAV2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729048.1">
        <property type="nucleotide sequence ID" value="XM_001728996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAV2"/>
    <dbReference type="STRING" id="425265.A8QAV2"/>
    <dbReference type="GeneID" id="5853355"/>
    <dbReference type="KEGG" id="mgl:MGL_3836"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3836"/>
    <dbReference type="InParanoid" id="A8QAV2"/>
    <dbReference type="OMA" id="TERDAWD"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38758">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="62734" checksum="E5A01A11B06669D5" modified="2008-01-15" version="1">MRQQKEEERLRKEQEKAAEEAAAREADRKRQEELQRKREAERKEAEKKEAARKEAARKEAARKEAERKEAERKEAERKEAERKEAERKEMERREAAKREERRRQAERKAEERRLADEHKADERRRRNQERRQRLKKSESDLRSLAQAHAQAPATKQPHSLFSPSPSSTTTPASAPTHIPARKSAPFPAQVPASLPGTVDHALFASEPFAPLAFGSVTTERDAWDHQRLPSLGRHAFESLPRAATTHGPSGISHTAQPANMSSHGAPDFAPPPTTSAAPATPASFFDYMPSTTHALSHLSLHPTSTPTRRRGAGVGSGASHDFDLGLNALMPHAREAPSTGASTAASALPSTPSRPVVAPIGPIERPRRSLTTGNDVVAEGGVVGSAALGDDEPIEPRGRRTAANGPPLGTSPFGQPPLTTPGFYGSPWSAPGYHLGLGGLSISSPPTSHASSAAAAATAAAAAAATPGSNMAPASSMASVPPAPTTSHLGPIPSLPSLSTPSASMAHAFEPHGFQPAWGSSWDRARHAFEQQPIDGFSPADTLSDLAGVAHASPFVSGARSRNTMGSGTSTSAKFLPHAAGDSVHAFAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAY2</accession>
    <name>A8QAY2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldose 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729064.1">
        <property type="nucleotide sequence ID" value="XM_001729012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAY2"/>
    <dbReference type="STRING" id="425265.A8QAY2"/>
    <dbReference type="GeneID" id="5853371"/>
    <dbReference type="KEGG" id="mgl:MGL_3852"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3852"/>
    <dbReference type="InParanoid" id="A8QAY2"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25109" checksum="D729259FAB373520" modified="2008-01-15" version="1">MELGRIHVQYRARLVDDATTATPLNLTQHWGFNLGASSVAHRGTGVDGHALQLGGGARPLYRLVLDTDGIPTGALESCAGTRYDWSRPNQQIRADTDYDHFYVWGPSTAASNSETAGRRNAIDRNPVMATLSGPTGLTLRFRTNQTGVQMFVPPNACKEGARKVRHRIEPTKPELDGRHHAIFLEFSAPHATFLRPTLWNWAGHDTLLRQGETYQSVVTVELSQQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBI1</accession>
    <name>A8QBI1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728919.1">
        <property type="nucleotide sequence ID" value="XM_001728867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBI1"/>
    <dbReference type="GeneID" id="5853225"/>
    <dbReference type="KEGG" id="mgl:MGL_3913"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3913"/>
    <dbReference type="InParanoid" id="A8QBI1"/>
    <dbReference type="OMA" id="ELMWAHC"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="778" mass="87659" checksum="92200366FFCD163E" modified="2008-01-15" version="1">MEAADGVEDEDENDAWNSQDGDGDASSSTDAQGGHRNSATIAHDFDMDDDEKSLWNEDKNFSHANDAIVAPTYTNVKVTRSMCMQNDEELRSDLEVAHEAMQLFLNSQMLEAEELCVEGAESRLYRSACMSMINVIKSLMTFEPDDLRIAIKCCKHTKSVAGVLRKGHGKLSSLLPGKSTLNDMSRLQQHAELVYAESLLHKSILSILYTGDTVGLIREAMSLRTAYLCLRNLLKMVEAGDEVVDEANRTGQSPTKSIDEDLRSGVFFNMGCCMLVLSVLEPRLLKFMEGVDFENSRPKALAFFERAGGWTRVQSEPRIPVTQEGFRRPLCDLAILVYHLVIPSSVPLPDVDLVMADHVLTWNQRRFPQGVFYLFFSSLMYVSQALPDKAIDCFRLAIDSQKAYKQLHHLCYWRLALAYLSLCEYKKASECFDLLVRESNWSKAICQYGKAAVLFEESSDNHMQAESMMRTVPSFARKMAGRHLPFERFVTLRAERFSQQTPLGLPAMEFAYLWHCLAQTPVFILLDEQLKRIDHVLRALQRFESPDSFPGGATAFYSQFCLAHFLRGVAFRYVAFPKKHTVLQYPLNDRPDVAKAAVEAVTSLSKVCENGMRLDAVDRYLVYFAHYELGNLYCAKGDFAQARFEFELILSHKALVPQTRPLKSDKASYLLSHACQMRANIAMESMQHMLSQFGPPRSSGLRSSAPSGAAPPITTTTMPTAGAATAENIAMQMPFAQSTTQRQFTPTTHYNDIPEHFTRSSSRSRDISRRARQSRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBS1</accession>
    <name>A8QBS1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728942.1">
        <property type="nucleotide sequence ID" value="XM_001728890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBS1"/>
    <dbReference type="FunCoup" id="A8QBS1">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="GeneID" id="5853248"/>
    <dbReference type="KEGG" id="mgl:MGL_3936"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3936"/>
    <dbReference type="InParanoid" id="A8QBS1"/>
    <dbReference type="OMA" id="EAFHFCY"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="472"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="704" mass="78382" checksum="A1AFB7C5D343C7DD" modified="2008-01-15" version="1">MAQRPGPGSSRTAESGAQRHLPLPGISSTASALRTRRNESRAGEHPEEMDDFEVETPGDAALNELPSGIIMPSVKSSRVSQSSSQGMTDPSKGQGGRTKTLKAGAAPLRAPRAPPPKLPGSAVIDKPGLQFKGTPARLPRYSLPVRAEKPVRASKFSGRHVLLPSESQLAPLPVPTTKGKKGMKQKTEGYTKEGGAGNGGKEEEDDDDDDDDDDEDDEDNEEVEEEDADESGHVTHGGDRAKLEHRRTHRRPQQRKNPVYYTFERMSPLTRATTPLPRLTSYAVSTSLQLQTALAFIRREHGVRPRLYEGCVYALYFKPLLPGFGRASVRSSRVPQTGSPGAESRHEREIQRDDESGYIGNYFVPQSERDIDTDGYIPNEHREDAIQPAHHHHHHHPAQMLPSNSASEEPSDPDSASARDMLMVEEDAQDRHQMKAGTRVVRVNQASHTHEADVNEHAPQSVRDALDMAELVLLPYGVVVMFNFTQEEEELILADLMTSGAIRNPHKAYDRELFHFCYDPNVRAPRIMNDFFTFREPNHLLKLSLAHAIAQSTKLSEFEENMHNTLELTSHIPKELAQTGELRVSRRGALRMSGHLFKLRVDVNLTSDVLDTPDLFWNEASLQALYDAIRTYLEIDERAQTLNERLAVANELLEVIHEHLSNAAMSKITWIIIILIVVACIVAVGEISARLIQHAGKTVNVYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCE3</accession>
    <name>A8QCE3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728832.1">
        <property type="nucleotide sequence ID" value="XM_001728780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCE3"/>
    <dbReference type="STRING" id="425265.A8QCE3"/>
    <dbReference type="GeneID" id="5853138"/>
    <dbReference type="KEGG" id="mgl:MGL_3999"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3999"/>
    <dbReference type="InParanoid" id="A8QCE3"/>
    <dbReference type="OMA" id="QERTITH"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="583"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="868" mass="96282" checksum="D11E6F1DDE094210" modified="2008-01-15" version="1">MPQVLSLPDVYLEAQTTEPHTALLYLLSQYNHLVSEFTHLYTHSHTGNDLNLDRSETLGLGFDALAPPTSLTGRIRNLRRRSFKNLRGDSNKSSVTHAASQVHDISAENSSGSLELTSPSSPKRDQGTNNLLQVTSPSPRIWNKSSSSALYAHGRMPESPSQRGSSALPSRQSAATSPKMPSRSPTISSSRTLGRKSNSRPATPVGRLLEDSFQHLVTEYCPFSLVDIQVCGSMVRGLQGPDAVAVRIRLQPPASVSEASVRRRQKSIRVEKRWSDLVALRELIAARINSQPGLSNISLCPVPDQNYFEPPYNPLHLAERNAAVTAFLHSLQGLPSLFEDIMSHFFATNLVPDSEVDSHYGSCFQQDGLLLGTGEGWTFVHCALFANLFIMQDPYKKQAPLLFDLRKTRIGRQFETTAPGREANSRTAMIILQKMQSSPNVQQPQIKLATESFCQHTTWMAALLREGEDNRSDRSLSEGMLDKDVNSSAALASTVLTKESDEMQHLNSSLRTDRTVLVPESSSVTELSRQGSAIKNRLWHGNDQSSTFVPTDKRRFLFGILPLNTPDELSTSSSTSHKAVFGAPLSDVVRDTGMFVDGIAGPVPALLKRSFDFLEQSSIISDEGLYRVNGSLSTIKVLQERFSTFGDIHLVAEYQEAKRTGNGSLLDSHAVTGLVKMFLRDLPEPLCTDVLMPDFVAAIEQENHEDKLQTFRRLLAYLPAENYSVLSLLFLHLNHVATMSHMNKMSLQNLNIVFSATLRMPTELVWTLLHDYYLLFHQQKLFLGEHREPTMNFSASPKNDTTAKVSSLHGRMKSLSLRSPNDRKSGHFQRTSDAPLFDSKLSSFTNPDAFPVPKEPETSILAGKDHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD71</accession>
    <name>A8QD71_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728804.1">
        <property type="nucleotide sequence ID" value="XM_001728752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD71"/>
    <dbReference type="STRING" id="425265.A8QD71"/>
    <dbReference type="GeneID" id="5853042"/>
    <dbReference type="KEGG" id="mgl:MGL_4139"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4139"/>
    <dbReference type="InParanoid" id="A8QD71"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="259"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="889"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="637"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="891"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1133" mass="125452" checksum="07975EB2C7C6BC4D" modified="2008-01-15" version="1" fragment="single">MSATTRSQLREPLRPHVSLLQTDARGKFELPPLKHVSKPDEVRGAGRPRSVASPGPIGTDVKVHSVQTDHKLASNPFVQQAAAQAREAAAHVNERSPYRGRGRENRPIHPSAAGAVTTKAGGSKPETGFAAARRLFAAPASQESSVMSRSKTARKISEASGALGTSRIRLSRQSLASFPSVEANVSKASSGTSVTATTAAAAAAGVAGAGAGAAGSTSALGTRSVLPSMPEHASSVSGLGGGSKWLEQERDNIQAYEYLCHCSEAQQWMERCIGEPLGGDIANMAEEMRNGIALAKLAKSFEPACVPRIFVHPKLQFRHTDNINYYFQFVDKIRLPNCFRFELTDLYEKKNFPKVVYCLHALSHFMAHHGRSDKVDDLVGKLEFNEEQLCKTQKTIDAAGIAMPSFGGVGQALAQEIGAGASACGSADARTAGARRAGANASDVRASSVQRAPEASTLVTQRAHLRPVPASPTKAKTATATAIATGAAPHSVASLRAHLKPVDSEPTLRSTDPRARDALDRERERERDHDRQRDRERERIARMEERERARVQREQREHEQQERERERIRLREERERRVQELERDRVQKRKDQQLERERERERLRLESQRELADDRERRERLYLNARTSTQRELALQREHESALRQRMEERMREAEDRARAQEQARADEREERFKRELEYEIQRKREMDAYAAELAAAHAETAAVEARLLALTEEAARRDAADRARAETRLAVPLQAAVRGLLARHAHNARRMPIRSHAATWTHLQAHVRGALVRQALYTTLSSLDDIWAVQMQAAVRGILARRSLYATIMQAEAHADSITHIQAMVRGMLARRALLAKMRAMDESMACATGLQAAVRGALARRAFRQMRMAFSRVAVVKAGSPASGLATIGTSRGPAASGTSGTSGASGASETSRASRVSGAPVSVRASLSRKKHHQELRKRMEYVRPDVSGIQAQIRGVLVRQDYSWWQAHLHGSVDVVVYLQAMLRGVLARRAFDDGLGRYLAHVPDIVRVQSLFRGRRASAHYQALLRGHHVPLETVRVYAHLLDDGSRDYDDEVQLTQMRTQVVQRIRENQSMETHVADLDRKIALLVKNQIGIEEIVKAKTERGWLGAGSATARDHVLTQANDPFAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR27</accession>
    <name>A8PR27_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732808.1">
        <property type="nucleotide sequence ID" value="XM_001732756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR27"/>
    <dbReference type="GeneID" id="5857114"/>
    <dbReference type="KEGG" id="mgl:MGL_0583"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0583"/>
    <dbReference type="InParanoid" id="A8PR27"/>
    <dbReference type="OMA" id="QLWAVRI"/>
    <dbReference type="OrthoDB" id="76224at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="275" mass="29482" checksum="E6DE3198FD468524" modified="2008-01-15" version="1">MAVQGASRANTNRNANDFEPPPGYVPAHLSSDETASHGDEVWVIRVPDGVDARALDGVTIPLEALESASSSPLASVRVSETDTYDVLQARGSSSSSSKAPSSAQPAASQLIEMAAPTTTGHVFLDEEFLRSEQNAGVAAELQSICALMPSGSNGSSLRMTPVSRRFYMARQAPSSLYPHGIPVPVPPKHKQPWDRLQGVFHPAGSQRNAPTSRAKGTDDVDRRRNEHDADEVNADAEASTQDADAKLDKAQKKRKKEAGEDSSKAEKKKKKKQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR42</accession>
    <name>A8PR42_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0598</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732823.1">
        <property type="nucleotide sequence ID" value="XM_001732771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR42"/>
    <dbReference type="FunCoup" id="A8PR42">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR42"/>
    <dbReference type="GeneID" id="5857129"/>
    <dbReference type="KEGG" id="mgl:MGL_0598"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0598"/>
    <dbReference type="InParanoid" id="A8PR42"/>
    <dbReference type="OMA" id="YMGENTC"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="11">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="68" mass="7184" checksum="F98537E167A8133A" modified="2008-01-15" version="1">MGLFGGSSSSASASNANSPQLDAAMAELDMITDVFNRLVESCHAKCISPRYAEADLNKGESVCVDRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR45</accession>
    <name>A8PR45_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732826.1">
        <property type="nucleotide sequence ID" value="XM_001732774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR45"/>
    <dbReference type="FunCoup" id="A8PR45">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR45"/>
    <dbReference type="GeneID" id="5857132"/>
    <dbReference type="KEGG" id="mgl:MGL_0601"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0601"/>
    <dbReference type="InParanoid" id="A8PR45"/>
    <dbReference type="OMA" id="FFIFWDR"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="164"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="374" mass="42900" checksum="717510C6EBDE8727" modified="2008-01-15" version="1">MGDAAVMTAAEVQGLVARTLPSFYTSSPRFLQSISDHDLALLLPILIYWGASLAYHALDVIRPAWSEKYRLHAPEELEKRNRVSMKRVIAMVAFQHAIQTALGIAIMEDTPATKTRRLDADPFTDIPALVQTMRSLHLPLYDSVLVRAAIALYWWGIPWLQFWFACFVLDAWQYMLHRTMHEVRFLYRTMHSHHHRLYVPYAFGALYNHPLEGMLLDTLGAELARVVSRMTLRQTMVFFTLSTFKTVCDHGGYAFPWYFNPIHALFPNNAAYHDVHHQTQGLRYNYSQPFFVHFDTILGTRVDPEDFHTMLEKKGLQTRKIASAKNDNEAEEENARPARLPVPKRSSPYSTATVWSSVLFMGILAVPVLVYSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR46</accession>
    <name>A8PR46_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732827.1">
        <property type="nucleotide sequence ID" value="XM_001732775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR46"/>
    <dbReference type="STRING" id="425265.A8PR46"/>
    <dbReference type="GeneID" id="5857133"/>
    <dbReference type="KEGG" id="mgl:MGL_0602"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0602"/>
    <dbReference type="InParanoid" id="A8PR46"/>
    <dbReference type="OMA" id="CFNARER"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="935"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="746"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="824"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1132"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="448"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1155" mass="121371" checksum="81CFF15515BE7CA8" modified="2008-01-15" version="1">MSAQAHTRASVCVSAPILLASVYTSYAIQLMHARAAMSITSANAPSVISAASLSAHISDLTQAALDAVAAQASASRVELFITSPTTLLLTAVRTDGTQASPFAEAADTSNTPWYPSATYPIAALGLLIHVLSWLVHNVAQDSRVVIHPSVDAPANQTLVYVYFDATVPVDETSWPPWLGPYVDMQTVLDDIGCHLVQTPVSLETLQDKPYFQPLLHAQHPTCLNITLKRPASSDLMSSEPNTERDVPLIAPGITVLSAMQIIHLRRVHFASPDDDLCRQLQEYLVDWQCSLVGLDQQPEIAIVHHDQKQLHAMAKAQVPCVFLAPLPRIVSVLQSMPPRCMALSEPISRARLAYAIYCLLYKDNGSPRPEANEQARIAQALPPQGPVPLPVSMQAVATQMVTPSSDLSSPDARHGLGLGLGLGLIPMSNNVSTPTSMPSLASSATAEPTRTPVPTSTSASTSIPAPTTASTAALTEAPTPVQAPTSAPSTTLSTTTTAPPPVAPTSSALAPASMAMSAPAPTPVPPLALEQASVSVPAPPPASVSASSPHLAHDSSSAPAPDPHAIADLEPGSCQVSLGTQEPKSDPVSTSTSASAFTQASQPVHSPAHAPPAAPVHSSTGSVSTPASGASSATRRASLSSSASLAARGITHPATTNVRASSRSPHPMPAGSASMSMAASGMPPTSMIASPTLSSSSSSVPAISAASYSASPATASDVVSDAADATTDYFTQAVSRLASHANTAGGRLVHGADGRPAGLYFQPRETPPDPGSRVSPRTKNKHASEPLSSSVPPPSYPSASMLRAAQLSMRGMPGVPSVGAFPPNSPQLPTTLSFSQRERGSRPGAPTSIHLPPLQFDPKAYPSRPTPYAHLPSRSVRTSAQPQEGVMIGVRDESWRRTNDAALSPPYAPPLSPQSSTRIQRRKMALREEFLPPVKVLIVEDNVINQRILATFLRRKRIDYDMAKDGHEAIDKWRRGNFHLILMDIQLPGLDGIQATKEIRRLEGQLRLSQQRKSPRSAQDPALHHYHARHSVIIVALTASVLSSDRVEALAAGCNDFLNKPVSLPWLQRKILEWGSMQYLLHAGLSPCGTSTTTPTFAAASESACPSMGALEAAFHRQADQMADQVARHLHLPTIPSPSGSPLPSPSPPATAPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR63</accession>
    <name>A8PR63_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">MGL_0614</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732839.1">
        <property type="nucleotide sequence ID" value="XM_001732787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR63"/>
    <dbReference type="STRING" id="425265.A8PR63"/>
    <dbReference type="GeneID" id="5857145"/>
    <dbReference type="KEGG" id="mgl:MGL_0614"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0614"/>
    <dbReference type="InParanoid" id="A8PR63"/>
    <dbReference type="OMA" id="RIWFRPK"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 22" id="KW-0349">Heme</keyword>
    <keyword evidence="12 22" id="KW-0408">Iron</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="24">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="25">
        <location>
            <begin position="105"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EDP45625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="493" mass="54849" checksum="4186437088BC9DA9" modified="2008-01-15" version="1">MGKLTYDEVAKHSSADDCWIILYGKVYDLTEFIPEHPGGPQIIVKNAGRDATKLFDTVHPKGTIEKYLSADKFKGEFDESTLPGEYKEQQKKEEAEEQERRANLPPMSSCLNLHDLELVASKVLSPEAWAYYSSAADDLETYHENKTVFRRIWFRPRILRNVRVVDPSTSILGIPSKLPIYITATALGRLGHPDGELNLTRAAAKTGLIQMVPTLSSCSFEDIVNARTEDGAPTQFFQLYVNSDRRVVVDMLRRAEKANIQAIFITVDAPQLGRREKDMRMHFSDEGSNVQGGEIQNRDEGAARAISSFIDPALDWDGALWIKRNTRIPVLLKGVQTWEDAVMACEMGFAGVVLSNHGGRQLDYARSGVEVLEEVVRELRKRNMFPSPAFQILVDGGFRRGTDILKAIAMGATAVGVGRPFLYAYSAYGVDGVVHAINLLRAELEMNMRLIGANTIRDVVPEMVDLRALHTHNGLPTPGDGSSVLDVMDKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR78</accession>
    <name>A8PR78_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732849.1">
        <property type="nucleotide sequence ID" value="XM_001732797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR78"/>
    <dbReference type="FunCoup" id="A8PR78">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR78"/>
    <dbReference type="GeneID" id="5857155"/>
    <dbReference type="KEGG" id="mgl:MGL_0624"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0624"/>
    <dbReference type="InParanoid" id="A8PR78"/>
    <dbReference type="OMA" id="ILVMNDM"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="354" mass="38022" checksum="C27A5F47BEC5E561" modified="2008-01-15" version="1">MRAHARVLHTTTKDASAWPVPMKQGSTDRILSPITPSDLQRKREEGTPLVCITAFDQPTALSVRAAGADLCLVGDSLTNVALGHASTRVLSLDAMIHHARTVRAGVQAPELQYDARCPRAPMVVVDMPFGAYGVSFDESVRNVVRVIKETQATAVKMEGSTELVPLIEHLTTLGVDVMGHIGLQPQRFGDASGFRVQGATAESALNILKTARALEKAGCFSLVLECIPSKVGGVISERLRIPTIGIGAGPQTHGQVLVCSDIMGDLASPAHVSAVLAGLDGSDEHVSLSVPTPSSWPQPPKFVRTFAASHIGMQRVLALRQFAEAVRTRTFPENASEAYRIKTHEWERFVAMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRA8</accession>
    <name>A8PRA8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 69 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732234.1">
        <property type="nucleotide sequence ID" value="XM_001732182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRA8"/>
    <dbReference type="STRING" id="425265.A8PRA8"/>
    <dbReference type="GeneID" id="5856534"/>
    <dbReference type="KEGG" id="mgl:MGL_0009"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0009"/>
    <dbReference type="InParanoid" id="A8PRA8"/>
    <dbReference type="OMA" id="FGAYDMW"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="57669" checksum="82DCEFAF7D81B9C5" modified="2008-01-15" version="1">MSQARLLEMRAESYQNRVRIAPHEQLMLSDEEAIEYRASVPWKYTILKFLKWLRIREKSDLVIARISVALFAYMSIHFYVPSSLYIYVVCICFTAPAIFTTAILRLRHGRTDQKKRLLITGGICTYVIACLLADCFSTRPSYPHQPNTHSKYYIASLLHNSEAILPHYSHSLVQLTKELGPSNVYVSIYENDSKDLTPTLLHKLDGNLRKLGVRTKIVTAKRSEQESRKNRIERLSAYRNLAMAPLNDELHGKLDGIPFEKVIWINDILFESSTVHQLLNTEGGQFDQACAMDYCWLGFYDTWVMRDADGKTTRPFWPYFKAEQDQKAVQAGLPVPVNACWNGLTAFDARWFSNTTISPNETMPFLTSALTLNPPPIFRADSLDVPATVPLTFRNSDLCFSSESLLSSLDMHRIARPYRPRIYVNPNLVVAYDKPNYFLYRSMMRWSVVGPWRHFWQYWIEHRLFGFALHVLGRVDPCTDVFMPNWVPRSPSKGPNIDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRE2</accession>
    <name>A8PRE2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732257.1">
        <property type="nucleotide sequence ID" value="XM_001732205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRE2"/>
    <dbReference type="FunCoup" id="A8PRE2">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="GeneID" id="5856563"/>
    <dbReference type="KEGG" id="mgl:MGL_0032"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0032"/>
    <dbReference type="InParanoid" id="A8PRE2"/>
    <dbReference type="OMA" id="NIKYWRP"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="127"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="620"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="914"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="917"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="939"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1057"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1110"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1217" mass="133220" checksum="2A9F706FBD1579B0" modified="2008-01-15" version="1">MSRFVSADDADYASLQEQLLRRSGTEDTETSGISLGMNEGDNEVDEAGATSANTPKKSALTENILPRRRNSDLEIQKPEGSFSARKGDFESLSSSAAAGNSYSLLRGANNLTGTQDAPIRKLGTWDGVFMPVTLNVMGIILFLRFGFILGQTGLVGSLLLLVGSYAIDTLTVLSLNAISTNGQVRGGGAYYLISRSLGPEFGGSIGLIFFFGQAFNAAMNVLGFVESFIGALGESNGHSGMLPEGSPFLYLYGTIVLWLCTLVCLFGSSLFARATLLLAIILSLAVASIPISSILVEPFEDSARDVYYSGWNWLTFAENLWPNFTAGAAGSSTAPEKENWRSVFGVLFPAVCGILAGTSMSGDLRKPSKSIPKGTNWALAFTFFVYALVFVILAGTVPRESFYVNLTIVESVSRWPSIVLLGELASCAFSALMGVMACAKVLQAIARDDLLPFLAPFSQGTVQSDVPTYAVLFTASFCQLVLLLDSINLIAQLVTMTTLLTFGVLSAATCALKAGGAPSFRPSFRYWNIWTAGAGTIVSFGSMLMTDAYTASVCIAVTVLFFIMIQVLSPPKPWGDVSHNVTYHFVRKYLLRLDERKGHVKYWRPQILLLANDPGKEWNLIIFCNSLKKGALYVLGHVLKGDFHECLPQLRKSHLAWLKLVDVSGIKSFVDVVIARDVREGARNLILSSGLGGMRPNIIVLGFPAALQRTSEQPRGPIARVRPSEPVALTKHAMPDVEPIDCTKYVGILEDALALNKALAVAYGFDAMDLPGPSKVAQYEPARGEQYIDLWPIQIANSACGDTPTWDTYTMVLQLGTILSFTGTWRQHKLRVSVFVEHPEEVQAEHTRVRTLLDNLRIPASLRIFCLSNGSVPRYDAIVLGKRALDPELGEILRGDPWWSQVCCVRRAVEKKKHQQHHDEHSLPQQLHKSEPIDTNNMRRSNSSSSLDSRQRKRHSRQFGVSLPDEHLAYHYNNIRLGLSHPHSQDVEGSDDEPDAFRLDTENTIDDLESELASLAVDWDPRYLMRQRRVRPRTESDALFDGTPSTLSSYGTLSSSQRTVTPATIHTRQAQGSHNHNLSSSSSNGHVSVSPPASESLSPSMSPSMLSSAQTHPSYSQASTMPTHHKQRWIPMQQDHYTLSFNELPNRAQYLILNELIRRHSSRSTSVVLTALPAPAPGTSTNKEESVAYLRQLQNLYGGGPPILGVHATTLTMTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRX0</accession>
    <name>A8PRX0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732371.1">
        <property type="nucleotide sequence ID" value="XM_001732319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRX0"/>
    <dbReference type="FunCoup" id="A8PRX0">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRX0"/>
    <dbReference type="GeneID" id="5856677"/>
    <dbReference type="KEGG" id="mgl:MGL_0146"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0146"/>
    <dbReference type="InParanoid" id="A8PRX0"/>
    <dbReference type="OMA" id="YEIRALY"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="628" mass="70233" checksum="792BE251EAF0681F" modified="2008-01-15" version="1">MPFTKSALRAEKRMQVGGSGSSSSKGAGPSMMMRPNREKLVQQLDPDASVRGPGAWDMEDMHYEKALIRSLFEYVRAGELDMALDLCVQTSQSWRAASLRGAIFYHDPDVSAPSNGDLAGPLGNRTRSIWRRIAWKAALNVSLDPYERALYGALCGELSSVLAVSETWEERLWGYINARFEQQLEHGMIQTAPFADVQRTEETTAEATESLESIFEQLAHASPQATTEALDPYHIVQRAVITDSVPDLLSRVNARLPEMQLLDERVYARLVRFFAHLALFCHLIHIPLPVPLRAPILNAYVGVLQRAGQSCELVALYASSLELENAHEVYADFLCTLDPDTSLEDRRHALVQVKPHGMDPAIVARKTVDLLFAELVPAIVDEAEIREWNAHLSIDERRLILSIDWLTFFDATYADAIVQANTIMRVFLTTGRLHAAHSLLHRLPTELLTVLSEITVSEDQLVELDHWRIYFDVLNKSVAVRGLWSDAALADSHAEFHDWASALRSACDAARLATLELLELGWLQFPVSDPARQEQLALIRRKYIPEIVVSLHLMLVDTSHIVTENLAHALALPNLVADERLCLYMEFAVPASSSTHPLRKYLDHVREAALLALDRRQDVLGCNAAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRY9</accession>
    <name>A8PRY9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732383.1">
        <property type="nucleotide sequence ID" value="XM_001732331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRY9"/>
    <dbReference type="FunCoup" id="A8PRY9">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRY9"/>
    <dbReference type="GeneID" id="5856689"/>
    <dbReference type="KEGG" id="mgl:MGL_0158"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0158"/>
    <dbReference type="InParanoid" id="A8PRY9"/>
    <dbReference type="OMA" id="KLYCLLQ"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="175"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="406" mass="47159" checksum="EDC79799275F4E82" modified="2008-01-15" version="1">MELSARDKAKARVAQIEIYATTAVSFLLLVMACAHWFTDVRQRVATFQWLQGVWDVYEQYASVPRRPSHTSWDSWCDLVHSFTSSCFFLSGATNKSVVADGWEHVRSLWTTSPSSPKTMYRRDPRDVLFATTWGMVFFVVRFVLMQCFLLPLGRLLVSRPTTARDKAHYQAQLQRRIARFGQQAWILILYSVSLIFVVRVIQRQPFWIWKPQYFWLDYPATTTDALTKAVYLWEASNYIHQVFVINLEERRSDFWQMLIHHFVTLLLIGGSYACCFHYVGISILFLMDPADICLSIAKLFKYMGFSTFCDVLFAIFMLVWIITRHVGYAFVWWSCFKDAPALISFTNQLDLASGHMLTRTTYVFFLILLTALQAILLIWFSMIVNIAVRVLTQQGAVDTRSDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS09</accession>
    <name>A8PS09_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732395.1">
        <property type="nucleotide sequence ID" value="XM_001732343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS09"/>
    <dbReference type="STRING" id="425265.A8PS09"/>
    <dbReference type="GeneID" id="5856701"/>
    <dbReference type="KEGG" id="mgl:MGL_0170"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0170"/>
    <dbReference type="InParanoid" id="A8PS09"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="311" mass="34692" checksum="F52732FD72470E29" modified="2008-01-15" version="1">MLLTQRDKLPASLAIARSALSALAMRLPTSEVWAWRQVGAELSGLVDQARDLVSQYERVQTEGTPLERHLWFQQGTSFDGCWECLSLVQALWCYAVVGAFDDSMGPAHKGTAASMAQRVWNPSLLPSAMTVLEQLLCVLASIGTTLQAQSWKCSTVSSNAKSSDTFGFLWWGLCESIRRSVLATHALLVVWQYTRAASEETHAPAPRLGSPLICQHIPSKVWDHIMQLELPAIASVFEADNVTQWRLNMEKHATQHGVSEQKLSLMMCMQYRPSSASEDRANIPFYLTSYFHHHDEFTNICLCALFGLTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS16</accession>
    <name>A8PS16_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0174</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732399.1">
        <property type="nucleotide sequence ID" value="XM_001732347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS16"/>
    <dbReference type="FunCoup" id="A8PS16">
        <property type="interactions" value="893"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS16"/>
    <dbReference type="GeneID" id="5856705"/>
    <dbReference type="KEGG" id="mgl:MGL_0174"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0174"/>
    <dbReference type="InParanoid" id="A8PS16"/>
    <dbReference type="OMA" id="HIIEYVI"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="12">
        <location>
            <begin position="13"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP45185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="338" mass="37486" checksum="EE2D412BD4F2977B" modified="2008-01-15" version="1">MPRNRARSFLREECRILVIGAGGLGCEILSNLALSGFQHVHVIDMDTIDVSNLNRQFLFREKDIGQPKATTAAAFVESRVPGVKITPHVCRIQDMDVTFYMQFHMVICGLDSVEARRWINATLVHMVDEKNPSSLKPLIDGGSEGLKGQARVILPTITSCYECSLDMLPKRTTFPICTIANTPRLPEHCIEWASVLEWPRANPGKKLDNDNPEHVQWVLDTALGRAESFHITGVNWSLTQGVIKNIIPAVASTNAIIAAACTQEAFKIATSTAPYLNNYMMYTGNEGVYTFTFDYERRADCPVCGGDIRSLTLTPQDTLATLVDLLSTLPDMCVFAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSL1</accession>
    <name>A8PSL1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732502.1">
        <property type="nucleotide sequence ID" value="XM_001732450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSL1"/>
    <dbReference type="FunCoup" id="A8PSL1">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSL1"/>
    <dbReference type="GeneID" id="5856808"/>
    <dbReference type="KEGG" id="mgl:MGL_0277"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0277"/>
    <dbReference type="InParanoid" id="A8PSL1"/>
    <dbReference type="OMA" id="NDRESLC"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF108">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="278" mass="31018" checksum="6899AD521648B786" modified="2008-01-15" version="1">MLIQVGGHPGIVQECGQYVLKSALNTETMFYETTYKTSGGSDAKKAMFRAWMPLCYGIADAQGHWLPGWPRIPLDDVQLPQLSIGSHTLVLENLVRPFVYANVCDIKLGTILYNDQNTELSSEKRERMHQKAFDTTSGTFGIRITGFCTWDASKQAFVQSGKAPGKAARTKEDLQRLLYDAWVVSSPVRERVIHTHLLPRIEALRDTLAHVPVKIRSASVLVIMEGDDARLQALLARGERVLDVRIIDFAHSRWAEAPDDGVLLGLETLYELGSRLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT77</accession>
    <name>A8PT77_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732605.1">
        <property type="nucleotide sequence ID" value="XM_001732553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT77"/>
    <dbReference type="STRING" id="425265.A8PT77"/>
    <dbReference type="GeneID" id="5856911"/>
    <dbReference type="KEGG" id="mgl:MGL_0380"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0380"/>
    <dbReference type="InParanoid" id="A8PT77"/>
    <dbReference type="OMA" id="EHAMSPR"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="518"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="541"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="413"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="580" mass="61380" checksum="72C96E15B4C118AE" modified="2008-01-15" version="1">MTGLPPSMYHPSSSGRISRGHSLDRGRLLGDQALVQRAPPELHRAGSWSIHGASVPQVGSGTPWDTDTPIASPPTLSSGRRRPRRTLTDNATEFLHAVDDLLGSNVPRHAPPVSHIMSPADGVRSPASPFGPPPIGMSEHPFAAAGLDAPSLRLGASKFGFSMPNSAVGSPRIRPQEDRFLNNPSSSSLSADWPAPTTTDPEYTRSMWSSVRLPGQVPDPLLYGAPSGSVLSSSPDETTAPLHAETSVAIALGDDEPHPNATQSPPFAVHSRPEVFERTPTFSSIDHDLASRMRSMTLPVDLSIPPLLRDRAGSMNRLHESPPPGHRVAPRNASKTGAHAMYSPYVPSPPPPLSFSSAAAFASPSSVTSPNIPDSPEAVSFEHAMSPRSMKRREDGKWFGRPGTLRLGDTVQVGPSSSSSSTPTPAAASSTSAPAVSGAPAASVEEDAMGPINNPGMTAPSQLGRAKPNVAHDVHGVAESFDASMRRRNSARSRTVAHAAAAYEGAVNGGRFHRREDGSSGPLRTVPPPLQEGAGHWDFGDVRGQLAEISMDQHGSRLVQEKLDHCTPEERTLVFEELFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT90</accession>
    <name>A8PT90_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732611.1">
        <property type="nucleotide sequence ID" value="XM_001732559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT90"/>
    <dbReference type="FunCoup" id="A8PT90">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="GeneID" id="5856917"/>
    <dbReference type="KEGG" id="mgl:MGL_0386"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0386"/>
    <dbReference type="InParanoid" id="A8PT90"/>
    <dbReference type="OMA" id="NALPCDT"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30861" checksum="209CB41B541ED320" modified="2008-01-15" version="1">MAPTSRIYLTRHAEAEHNATGDSLIADALLTPKGQQQAERLAYMTPDLQERVELIVTSPLRRTLQTTEAGYKPAIARLGGHTKVICLPQLQECNDVPCDTGSARHVLESQPDFAKYDLSSLTPDWTSKRGFYAADPVSLDARAQWVRQFLRERPEQHIAVVAHGDFLRRLTDDPMSYWGNAEVRAFQFAPSSVATDACPIVHVEVIEKGDWNGEKVVSGTQNLSTMEARVKQIQASLKSQTNELEELDRMLEETERRQMELVSRASTTTGPSHGGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTB6</accession>
    <name>A8PTB6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732623.1">
        <property type="nucleotide sequence ID" value="XM_001732571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTB6"/>
    <dbReference type="STRING" id="425265.A8PTB6"/>
    <dbReference type="GeneID" id="5856929"/>
    <dbReference type="KEGG" id="mgl:MGL_0398"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0398"/>
    <dbReference type="InParanoid" id="A8PTB6"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="148" mass="15877" checksum="395D48711AF7E227" modified="2008-01-15" version="1">MPSAGVRESRKTQHAKAASKLPEQSASSGSSSPIGLDNTGSNVLGESTSLSLAGHALPPPKAVAKTLAQFKQVRRLDVSDIQVSESWPDGLRDLDWLVKAVRHSQKARRDEQALDERLTWLNVSKNPALGQQSDPLQGIEVLASLFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTC0</accession>
    <name>A8PTC0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732625.1">
        <property type="nucleotide sequence ID" value="XM_001732573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTC0"/>
    <dbReference type="STRING" id="425265.A8PTC0"/>
    <dbReference type="GeneID" id="5856931"/>
    <dbReference type="KEGG" id="mgl:MGL_0400"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0400"/>
    <dbReference type="InParanoid" id="A8PTC0"/>
    <dbReference type="OMA" id="VFPMETT"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="110" mass="11883" checksum="DDDCA8ED995DDD07" modified="2008-01-15" version="1">MAAHVKVVARFRPAHAPGDRIQSGDDAVIVEHKDSQSVSLSRGSDATFTFDHVFPMETTQAHVFEHSIKGTVDDVLQGYNGTIFAYGQTGSGKTYTMMVCGFMLGRCGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTQ7</accession>
    <name>A8PTQ7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732688.1">
        <property type="nucleotide sequence ID" value="XM_001732636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTQ7"/>
    <dbReference type="STRING" id="425265.A8PTQ7"/>
    <dbReference type="GeneID" id="5856994"/>
    <dbReference type="KEGG" id="mgl:MGL_0463"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0463"/>
    <dbReference type="InParanoid" id="A8PTQ7"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="146" mass="16261" checksum="295A69652D7F65F5" modified="2008-01-15" version="1">MTQEVPNENQVRHGLTNVHLGRGGAGNVRSPSRDPQEQYLHEQEKLRALEEQDAMQAQELVSQVYATGRGGAGNIPAQAPVADPPHERGRQLHETSRPERVSSPRNVASIFRPLSRSRSREPRTSAGRDSSLSRVAKFDRVREEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUE4</accession>
    <name>A8PUE4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732075.1">
        <property type="nucleotide sequence ID" value="XM_001732023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUE4"/>
    <dbReference type="FunCoup" id="A8PUE4">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUE4"/>
    <dbReference type="GeneID" id="5856381"/>
    <dbReference type="KEGG" id="mgl:MGL_0668"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0668"/>
    <dbReference type="InParanoid" id="A8PUE4"/>
    <dbReference type="OMA" id="WINQDSH"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="372" mass="42382" checksum="BB28CA9E0ED17358" modified="2008-01-15" version="1">MLPMHTPQEQERDARSQRASLRIVERDGDKPLRESLRSRGVTIVTPNANATESVQMNQTTLTPQQAAEITPSLWSTREFYAYYVAAMIIIPYMIYVPIYLSSDKRPEYPRYANRLVKGWMGGRLRDDSDHQYRLLRKNGVILMAVMTVYALLSHCIRWIAQQCRNTVYAKRIRLAFLGVTGLVFVTALHGANVIKLLLIALLNYVIASSAAWLPPAVVTCAVWMFNGAVLFLVFYTNGAPYKTLSLSLAWLDEHPGLIHRWYISYNFTMLRLVSFAMDYVWARSSRHQPVSAGSAGRESKVLSSKDRATWPHALSSYTFVTQITYLFYPPLFIAGPLMTFNDFYAQMCKPLHIPLRVIAGYALRCHRIGLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUK8</accession>
    <name>A8PUK8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732115.1">
        <property type="nucleotide sequence ID" value="XM_001732063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUK8"/>
    <dbReference type="STRING" id="425265.A8PUK8"/>
    <dbReference type="GeneID" id="5856421"/>
    <dbReference type="KEGG" id="mgl:MGL_0708"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0708"/>
    <dbReference type="InParanoid" id="A8PUK8"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="156" mass="17681" checksum="037FBFAA3C416053" modified="2008-01-15" version="1">MNSLIAKDETVTPNGLYVGVVTLASIVFTRHGSFPIRWAVPPVVLLASMKYFLPHTTQNIGEYYETKEQSYAPSFSKARREQWDRARQFWFTGMDHMQMTRERVSDTFASGLHDIEQSTGLKLSSLWHNRFASSPSSASSNELPATHEHTSSKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUL5</accession>
    <name>A8PUL5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732119.1">
        <property type="nucleotide sequence ID" value="XM_001732067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUL5"/>
    <dbReference type="FunCoup" id="A8PUL5">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUL5"/>
    <dbReference type="GeneID" id="5856425"/>
    <dbReference type="KEGG" id="mgl:MGL_0712"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0712"/>
    <dbReference type="InParanoid" id="A8PUL5"/>
    <dbReference type="OMA" id="GEKTWQQ"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="6">
        <location>
            <begin position="400"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="6">
        <location>
            <begin position="509"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc knuckle" evidence="7">
        <location>
            <begin position="961"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="836"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="931"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1015"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1015"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1041"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1050" mass="120109" checksum="6FB73C5C93DBDDE4" modified="2008-01-15" version="1">MDIEQDDAVTQLGGLALGQVLQDLGVVGADSDLSRIGLGSKKTATTPALHREEIYRNDFDDDADDDIKLGPVGQDDEDDTIMEDVTNLRKTPVNREPGRGKFLVRGEEEDFADEDEEDHQEGDARKGMVQLATVPTTQPPLNKTDELVAPKSALPYQQQQAEPPMSPTTEARMLFPDFQPGKLLDFTELFGTRSLKRRKLIGRLPQYTKPHVDISVRESDKDEFFSAEGFERERQPTFLGRIVNPHLADQEYESAKIHCQVLFDDSAIEDQSANGDTHEPIQLLNNVEVDDWQRRVLLDSHKDQAEFSTDEKLLPPVLSMETVSRPRNHELANGMWFENIIWNPHHPFRRFDRLLMDMNDAEMILENENTQREKQVSLLRADAPPNLLKSSKFAAELDPFNLSNDRMYEMSKEHRHRVRQTLGQLVVRHAWPAIKLQLPFYKTRLSKHETRSWHRPRIQFPSNMPITFSRVRTSRKSKDGERKSKDPSEVLHSTRDLTLKDASNYIMYAKDDHIPRSELGEAFVLDITDESPFMKFGSVEPGQTQPVLYNNMTRAPLFRHKPSQNDFLFIRSTTKNDVRYYLRDVPNLYVVGQTYPTTPIPGPHARLVTNNIKYRLQMITYKLVEKSHAHRIKIHRVMKYFPDQNELQMRQRLKEFMVYNRKSGDVHQGFWRLKPDVPIPDEAELQKLLTPEHICLVEGMQVGQRHLLDAGFTKTAEGADDDADESKLEIEQLLAPWITSKNFLHATQGKAMLKLHGEGDPSGRGEAFSFVRVSMKEIFLRAGEDVDERLAAEAETRAKSGHRYNVAEQQAIYRSEIARIWKAQLAALSNPEPPRITAKEEQLWRDEQRRERKQQEQKATRPLLVKRLFHGVWYKHIVRDPSVINAYVKQRQEIEEQSIVTESLVPTGDAALDAMRKKRLEEEIAARVKNQDRRLQRKNAKAAAEGIDGGYKKMPNKTNTKRRCGRCGQVGHMLTNNACPQYHADKANSGRPGASGANAVRPPSVMPMPNSTYYTSASTQQQGTAMPTTFPPFGMNDPMGPQSPPPPMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUN2</accession>
    <name>A8PUN2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732132.1">
        <property type="nucleotide sequence ID" value="XM_001732080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUN2"/>
    <dbReference type="STRING" id="425265.A8PUN2"/>
    <dbReference type="GeneID" id="5856438"/>
    <dbReference type="KEGG" id="mgl:MGL_0725"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0725"/>
    <dbReference type="InParanoid" id="A8PUN2"/>
    <dbReference type="OMA" id="MFANGAK"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="40"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="197"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="257" mass="27058" checksum="ED87D925ECE60E9A" modified="2008-01-15" version="1">MFANGAKTDYYSNNPLYECLVCSRQVSSNRYATHLEKCMGAGNKSTRKGSTRNAKTASTAVTQRILNTNSRSASPSTSSPTAAPRKQGSSSPAPQMPAAASKEKQSIKSEKPSTPLSKQVDLPHTSVLGSQSSHLSKGAADASYPIKSSGSTPQADSASAAGHADDEELFDDADFASGFSVSVRCTVFRRVYTNYVGGKSESEESGAHGSDVDEGETKAMDEVVDDIEFDLDEDDGSDNAVDLDVNGMDSEDDALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUW0</accession>
    <name>A8PUW0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0784</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DExH box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732191.1">
        <property type="nucleotide sequence ID" value="XM_001732139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUW0"/>
    <dbReference type="STRING" id="425265.A8PUW0"/>
    <dbReference type="GeneID" id="5856497"/>
    <dbReference type="KEGG" id="mgl:MGL_0784"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0784"/>
    <dbReference type="InParanoid" id="A8PUW0"/>
    <dbReference type="OMA" id="HPHQTVE"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001714">
        <property type="entry name" value="ATP-dependent DEAD/H RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000526">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF203">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="377"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="638"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1235" mass="138430" checksum="74FA078D0C0FC040" modified="2008-01-15" version="1">MAGRECLNLGKKSRYCWRVFVHLRQLTSPSKHSKSAASDFPVLSYPIQTSDEIKARLAHLVALAKTQWLDNPKNVVFAYVQSRTGSYPEFRFAEGRYHGKSHKVIRSTLVIDEEYNIVATGDGKSQKEAEKAAALHGVLLLLERDFIAHPPPGIFGSGGKGNSKVLTAALFDGTSVSLEQAREFIDFFCREGHFGSPDVVFHEAHEVRGRRVLIHGWKATMCIGGTPVGESLESNKKTAQNAAYLNTATTLADEYRDMWVKYLQMPRSKLAGKAPPVYFRVSNELEEKMRHLYDTIRDSELYANRPRTTAVLSSPPDATPATKKADATRHALSDEQHEQKSQQMLENLNAYQTDERVKSLRIAREQLPVMQHAGDILVKTELNPITVCMASTGSGKTTQVPQILLDDFTLRKQGSRCNIICTQPRRIAAISVAQRVAKERGESVGDSVGYQVRFDSKMPKPDGSILFCTTGVFLRRLQSALEDASGTSFLDNVTHILMDEVHERDVETDLLLAVIKRVLQDRRERGCPEIKLLLMSATVDPKLFQQYFEGFSARPVPVVEIPGRSFPVQKYYFDEIYQQLQELALPLNQGGWVWHEQSVRDYVHREIIEHGGRISDSVGSSDDKLIIDNLELPYPLVALLIAYVLTRSRDGHVLVFLPGWDEIKIVHQLLLNSKEYPLMGVCFDDSSQYEIHILHSSVPVTDQQAVFEPVRHPHIRRVILSTNIAETSVTIPDVVYVIDTGRVKEKRYDPERHLSSLVSAWVGTSNLNQRAGRAGRHRSGEYYGLLSMARYNRLGVSQTVEMKRLDLSNVVMHIKALNIPGMEVEDVLASTIEPPASERVQAAMVDLGRIGALDYHSNLTSLGKMLLHLPVDVNIGKMCLYGAFFRCLDPVLSLAAILTNRDPFMAPIHLKREANEIKNSWCPTTFRSDPLCVLNAYYEWNRLLSLHPSQANRFLYQNMLSRSTMFQIQQVKENLFQSLRKANVIQLIRSSAGVPPRYRRRIRETDPEFNANAHSTALLASLIAVSSPNFAVRTGERTFRTSQDKSCFIHPSSVCSAKFQKDKAKMSASPSMPNKDIYAFAEKVRNTSQMTGSAGHAMTFMRTCTRIDPLSYMLFGATEARASPQGLDCDSWLPVTGDYDALDGVERIKSVMDACILRVLEGIQIPLTNLTAKKSSIEPVASDVLNDTFSDDEEDADPTIPPVGPLTMHEVQELESLTSRIVDLLDHYASENPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV14</accession>
    <name>A8PV14_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">MGL_0816</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP45009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732223.1">
        <property type="nucleotide sequence ID" value="XM_001732171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV14"/>
    <dbReference type="STRING" id="425265.A8PV14"/>
    <dbReference type="GeneID" id="5856529"/>
    <dbReference type="KEGG" id="mgl:MGL_0816"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0816"/>
    <dbReference type="InParanoid" id="A8PV14"/>
    <dbReference type="OMA" id="HNAYFDY"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002724995" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="23"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="172"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EDP45009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="424" mass="47042" checksum="87281BF4B816A8D5" modified="2008-01-15" version="1">MRFTSAVSSGAIFSVSALLASAHVGPGLVYHDNGAKKLESRDYHMGRFMARARPSNAAQMAKVSDPTKECSYYGLPESSELSSAYPRDGTIATIVDGDEQAKQVWQEIQSSGVIPHGASPKAGTQDHMGLSPNALSQYDTNSDPDCWWSATRCTSPKKSKLSHDIVTCPEPSTWGLTFDDGPNCSHNAFYDFLKEKKIRASLFYIGLNVKNWPLQAQRGLADGHDICVHTWSHHYMTTLSDEQVFAELYYTMRIIKDVVGVTPQCWRPPFGDVDNRVRAIADGLGLRTIIWSDDTNDWNIKPSGELPKSKIDRNYEDIINKGKDGSGVVVLSHEIRADTMNEFMEMYPKIQQAYKHVVPLTACMNVSHPYAENNISYRSFAEYTSGNIRAKGLPSLKDMSVNPKSKLQITPVSKQKSGFSPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVN8</accession>
    <name>A8PVN8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731650.1">
        <property type="nucleotide sequence ID" value="XM_001731598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVN8"/>
    <dbReference type="STRING" id="425265.A8PVN8"/>
    <dbReference type="GeneID" id="5855956"/>
    <dbReference type="KEGG" id="mgl:MGL_0918"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0918"/>
    <dbReference type="InParanoid" id="A8PVN8"/>
    <dbReference type="OMA" id="WTIFDIT"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="77" mass="8560" checksum="87C1939B7CA7462B" modified="2008-01-15" version="1">MPNGKGWEDWTDDVWTIFDITSPKPGNTVLPVPSKIRARLHSMGIQLDVQNTRQACSTFNLLVEEGRNVAAALLPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVP6</accession>
    <name>A8PVP6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0923</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731655.1">
        <property type="nucleotide sequence ID" value="XM_001731603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVP6"/>
    <dbReference type="STRING" id="425265.A8PVP6"/>
    <dbReference type="GeneID" id="5855960"/>
    <dbReference type="KEGG" id="mgl:MGL_0923"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0923"/>
    <dbReference type="InParanoid" id="A8PVP6"/>
    <dbReference type="OMA" id="SWAEVYH"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725001" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="26"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1036"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="81"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="846"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1063" mass="117200" checksum="22BF421C5FC189BB" modified="2008-01-15" version="1">MLVRLVPVLVCAAVFLSLVPSQTCAYAFLQLLNPKKPSPPIVAHLSQYLGVPITDSDTPMRFLHPRMQRFIRDSQNVNDKASAAFVTLTDTGVLGALNPRDGGMAWRRLVDQDDHIRGLFSIDDDLLVVSSKNHLTARMLHGERGSIDWQYQTNDTIDGYPVYAASWTTGEFDALIVAGNKLHYVHGGNSTWVWQSSNENYRLLFATPYDNLVRIVGVVPSEDGHWSVDLTSLTIEGQVESAYVMGYTIENPDSIVLLPYRPRSHIDEKYHATEQGGPHIAWLASDGVIRAHRIIDGDVIIKEVRSNTSPYTDIQDVGLGNRGLFLARRADGTAEVIEVSAAGDMQSLWTFAEIAPDAVYDGALDREGNAYVMRMYYEPSQHMIQQHLFRADELTGDVRGVMTGLAFRYDYERHGPLRSAAAEVGKVSENTVSLRTVIVTASGSIQLIRDAKNEWSVEQGLSKPAKTLLVQLPEALLGRSAVSSRALPSWPLPFEALETESLMGRWVRHISELRHFPDALQAFARGPLYRGLQALGVYLEWILGHNPTEYVQKPTAGGPVLPRRPRPMDPPAQNSDTTLHHDRFGFDHLVLAASRYGKLYGINATLDGSNIVWEHAVVPYQQPQAVVNVTHLIQTRATNTLAHGVPVAPIVAVVAEVTMPQSVEDESDQSAEISMGELQTLVFKLNPLTGERVGPSNEPYVLCHGPAQDVYVFEEAVGAVCADGSVVSPKSHVGMHLVRSDAPHALKGIFLESLEVPTWRMAFAPSEKLVLMRDASRDHVASPGKVRGDRSVLYKYLNTHARLVLTFDTEAKSAHVYVVDVVSGDLVYHLVVPNVASDVMHATFVENWISVQYTGTNDDAPNMLLSVELFERETSGQSGLYSSSLVRAGSNETLAANAPPVAYAQIFALPFGVRAMETTRTNLGVASRSMVIATNQSDIVLVPRRLVDPRRPLGKPTPAEMEERLIPYRGMLLNDSLPLLTTMKDRAAHINMLRTSPTLLESSSIVLGTGIDWIYTIAAPSGQFDRLQASFNKPQLLLTIIGLVIGIMITQPLVRMRMLNARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVX9</accession>
    <name>A8PVX9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731713.1">
        <property type="nucleotide sequence ID" value="XM_001731661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVX9"/>
    <dbReference type="FunCoup" id="A8PVX9">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVX9"/>
    <dbReference type="GeneID" id="5856018"/>
    <dbReference type="KEGG" id="mgl:MGL_0981"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0981"/>
    <dbReference type="InParanoid" id="A8PVX9"/>
    <dbReference type="OMA" id="MCLKVKY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="324" mass="37059" checksum="282F5819B85AF4DC" modified="2008-01-15" version="1">MAVGNPDTWIAQLRECKYLPEEDMMVLCDQVRQIMLEESNIQPVSSPVTVCGDIHGQFWDLLELFRVGGNLPDTSYIFMGDFVDRGFFSLETLSLLLALKARYPGRITLLRGNHESRQITQVYGFYDECMQKYGSASVWKNCCQVFDYLNIAAIIDGRVLCVHGGLSPELRSLDQIRTIMRMQEVPHEGPFCDLMWSDPEEIETWSVSPRGAGWLFGRLVTKEFNHLNSLDLIARAHQLVQEGFKLMHDNNIVTVWSAPNYCYRCGNVASVFQVDDLLDPKSQAQQDEAQEESRFNPSHFKIFDAVPDQERTHPARSTASQYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW67</accession>
    <name>A8PW67_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731768.1">
        <property type="nucleotide sequence ID" value="XM_001731716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW67"/>
    <dbReference type="STRING" id="425265.A8PW67"/>
    <dbReference type="GeneID" id="5856073"/>
    <dbReference type="KEGG" id="mgl:MGL_1036"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1036"/>
    <dbReference type="InParanoid" id="A8PW67"/>
    <dbReference type="OMA" id="SWAFVIY"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="63433" checksum="18C1DD1BC9697AC0" modified="2008-01-15" version="1">MSLRMFKRQPPKLLAQFLVSLLWGIVPLSWVYVILYVGVRMAHERRTGVLLRMLLHGTMPREVLLRPWLANFLRKRFAFFWASLEVCFSIYYRHLVRRIQGRRRTSSPNSHTRIIRALGMSVVDGLDDDSLLANPRDTQKFPKLKEALARDDPRAIAFRKEMGGWFLGIRPEDITRLDVLNWLAWSIFDKYYDEVVLFDSPKHEMQLFLLDVLHTFEQRRGLRFPDRAVLSPIEEKRRRTMMLTLDPVDVHTRPLLLYILIFGLNRAVHAVLNMYGMRRMRMHGITYLLYMPPGWSVEAACKGEALRPVMFLHGLGLGLSEYVLPLFTMLRPNGVPASYPIVVPLQPWISYEFFSPRFLRPWQHEEAANVVRSILELHQFDKCKVHVLSHSMGTIVHTWFLRTWSSLIARSVFVDPVCFQLWEPHICYRFLYKPTESFIEFVLRYFVARELGNANLLMRYFDWTANVLVCDDIPEHHDPKHVRVYLAGADTVLNAWRVQHLLKRSGMQDVIHYDANLHHGELIMAPGHRVKEMLDMLHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW99</accession>
    <name>A8PW99_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731786.1">
        <property type="nucleotide sequence ID" value="XM_001731734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW99"/>
    <dbReference type="FunCoup" id="A8PW99">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW99"/>
    <dbReference type="GeneID" id="5856091"/>
    <dbReference type="KEGG" id="mgl:MGL_1054"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1054"/>
    <dbReference type="InParanoid" id="A8PW99"/>
    <dbReference type="OMA" id="CFRSASY"/>
    <dbReference type="OrthoDB" id="5550464at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40286" checksum="E044ED0345FC4A09" modified="2008-01-15" version="1">MVHIQHAEGRAVLRRAVPLDEVGAPRFSHLECKFPFRLLAPVQAANDATVNAAKYVDTADRSAPIKSVGILFTLGFGGGLISGDSVNLEIDVGEHTRLLMLTQGNTNVYRVRRGGDPVASIMRAQGPNEVSRQHTRYHVRKNATLVLLPAPVTCFARSRYAQTQRFDLHCGASSSLILLDWFTSGRLAVNKTDYRIPELWHFYMYHSRNEVRVNGDVIVRDRQHLAQDLPDQLQEDTRTDLAQRCEPYTCFGIVILYGIECEALCRSLSEEYDQIQQPQPLLRSGGTLGSSRVSPPEVLWSLSPLCSGAPVPGGNMKTGSSVDKGLILRVAGTETDTVRAWLHKHLLPVKYLIGDDMYRIALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWN7</accession>
    <name>A8PWN7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731896.1">
        <property type="nucleotide sequence ID" value="XM_001731844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWN7"/>
    <dbReference type="STRING" id="425265.A8PWN7"/>
    <dbReference type="GeneID" id="5856201"/>
    <dbReference type="KEGG" id="mgl:MGL_1164"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1164"/>
    <dbReference type="InParanoid" id="A8PWN7"/>
    <dbReference type="OMA" id="WAEVPDP"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="32"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="364" mass="39320" checksum="1A2665C5C711C1FC" modified="2008-01-15" version="1">MHSTSKVSSVPEMMRAVVIENETGPSSALRIGQVQTPKLPMHVTTPHVLVKVRAFGLNRMDLLQREGHYPVPPGASKILGVEFSGEVAETYDGNGSPGTATQLKVGDPVFGLTHGGAYAEYVTVPASMTWKKDASMSWEQAASIPEAYMSAFQALHTLSSLKHGEDVLIHAGASGVGLAAIQLAKFLGARHVYVTAGTPEKIERCKQLGATDGFNYKTEDWADQLKRATNGKGVDVIMDFIGASYFNSNLASLRLDGRMTLQAVMGGFKLPEGSNILPLLMKRLRIEGSTLRSRSIEYQSDVARDFARLGCVDALVRGAQPGESSGQNTLRTILHKVWDWHDIKSAHDAMTANQNIGKMVAVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWV6</accession>
    <name>A8PWV6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine dehydratase-like alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731964.1">
        <property type="nucleotide sequence ID" value="XM_001731912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWV6"/>
    <dbReference type="STRING" id="425265.A8PWV6"/>
    <dbReference type="GeneID" id="5856269"/>
    <dbReference type="KEGG" id="mgl:MGL_1232"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1232"/>
    <dbReference type="InParanoid" id="A8PWV6"/>
    <dbReference type="OMA" id="SAAMGGC"/>
    <dbReference type="OrthoDB" id="192663at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000001">
        <property type="entry name" value="L-serine ammonia-lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051318">
        <property type="entry name" value="Fe-S_L-Ser"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182">
        <property type="entry name" value="L-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182:SF1">
        <property type="entry name" value="L-SERINE DEHYDRATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine dehydratase beta chain" evidence="11">
        <location>
            <begin position="90"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Serine dehydratase-like alpha subunit" evidence="10">
        <location>
            <begin position="366"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="77090" checksum="4F13B3797C66F4E7" modified="2008-01-15" version="1">MLLYAWKQASPRITRFAAGHHGSLTRRIAWARSLHMTHEQTIGPDPDPESFSHTHFPKTGQGNKGPPNHTDRNDAMSSASHSSKEHAVISMFDLFSIGIGPSSSHTVGPMRAGAIFVHDLRKSALIESVARIKLALYGSLAATGKGHMTPQALLLGLEGAECETVDTETVPIRFEAIKKNKCLALGKDMPEKGPVKVIEFDYDRDLEWKWGQTLPMHSNGMRFSVFNHDGDLLATNDFYSIGGGFVVNGLMAVADKPGPRPAASNNARSENDPDAVTNALASLNEAAITPSQKESHPVDVMENVYYKSITRDDVEGGRREGTESNMALSQPALPSPSKLDSSEQKAPKEPRFPFRTMSQLLALTRKHNLTIAQIVYENELTWYTPEEIEEKIINIWNVMDEGIRAGVLSEQEVLPGSLQMKRRAPKLYNRLIRGLYMGPRRLGHMRGSSDTINVPLDSHESPSSAAAIASSSNASGGYVPSIKTRSSSRVPTIRGSFQHEIMPVPPRRTNFPAMDWLSCWAIATNEQVAAGGRIVIAPTLGAAGIIPSVLRYVVEFVALTPEDEENLVKTFLLTAAAIGMLFKRGATISAAEGGCMAEVGTSCSMAAAAFAACMGGSPEVIEQAAETAIEHNLGLTCDPVDGLVQAPCIERNAVGAVKAVVSANLALSTEGIHTVTLDEAIQAARLTAADMHTKYKETSLSGLATTVKIPVAVPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX15</accession>
    <name>A8PX15_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase CBK1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1291</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732023.1">
        <property type="nucleotide sequence ID" value="XM_001731971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX15"/>
    <dbReference type="FunCoup" id="A8PX15">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX15"/>
    <dbReference type="GeneID" id="5856328"/>
    <dbReference type="KEGG" id="mgl:MGL_1291"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1291"/>
    <dbReference type="InParanoid" id="A8PX15"/>
    <dbReference type="OMA" id="HDNAYYQ"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000828">
        <property type="entry name" value="Serine/threonine-protein kinase CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="164"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="471"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="539" mass="61229" checksum="6B3BBAEC751B9147" modified="2008-01-15" version="1">MDHTASWGAPSGGTSYGLGNGMTYPHTNHPETCTLHVTNKQASLSYGQVLAPESIDQHATQPTNLPAAQEKDYVFFERDTRQMNKATIDAARSAKIRLEHSYRMAVNQAVERSQRRTELEKRLLNPPDGALVSDERKARQLAQLGRRETSYLRLRRTRLGLADFRTVKVIGKGSFGEVRVVQKVDTGKIYAMKTLRKSEMLKKDQLAHVRAERDVLAESNSPWVVQLYYSFQDTAYLYLLMEFLPGGDLMTMLIKYDTFSEDVTRFYIAECVLALEGIHQLGFIHRDIKPDNILIDRKGHIKLSDFGLSTGFHKQHDNAYYQKLLEDPPPQSSSQSNRNSVAVNSITLTLSNKDQIATWKANRRKLAYSTVGTPDYIAPEIFLQQGYGHECDWWSLGTIMFECLCGYPPFCSDNAHDTYRKILAWRETLQFPDDIHLSPEAEDMIHRLITAPEKRLGRNGAQEIKDHPFFAGVDWTTIRQIDAPFVPHLSSITDTSYFPTEDYQDVPDVPVGADTDVGAKDLAFLGYTFRRYEANENAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX64</accession>
    <name>A8PX64_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731157.1">
        <property type="nucleotide sequence ID" value="XM_001731105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX64"/>
    <dbReference type="STRING" id="425265.A8PX64"/>
    <dbReference type="GeneID" id="5855464"/>
    <dbReference type="KEGG" id="mgl:MGL_1340"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1340"/>
    <dbReference type="InParanoid" id="A8PX64"/>
    <dbReference type="OMA" id="MPEAYVI"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="7">
        <location>
            <begin position="271"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="394" mass="41331" checksum="0658A7408F173D3B" modified="2008-01-15" version="1">MTNAFIVGSKRTAFGSFGGKLSNLTATQLGGHAAKAALAQLPSNTPVSSTVFGVVAHSDSTAPYTARHVGHYAGLPISVPALTINRLCGSGFQAVINAVQEIKTGESDVVLTGGTENMSLSPYTLHGVRFGNTRYGVDLKLVDSLAISLVDQVPVPTPMGITAENLAEKYGITRQQCDEFALQSQKRWLKAQENGAFKDEIAPMEVKVKKATESFEVDEYPRPHSTIESLAKLPSVFKKDGVVTAGNASGICDGAAANVVASEDAVKEHGLKPLSRIVSYGVTACEPSLMGIGPVEAVKLAMKRAGLSIADMDLIEVNEAFAAQFLAVQKELELPSDKTNVFGGAIALGHPLGASGARILSNLTYNLHRLNKKYALGAACIGGGQGIAVIIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX73</accession>
    <name>A8PX73_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731166.1">
        <property type="nucleotide sequence ID" value="XM_001731114.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX73"/>
    <dbReference type="GeneID" id="5855473"/>
    <dbReference type="KEGG" id="mgl:MGL_1349"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1349"/>
    <dbReference type="InParanoid" id="A8PX73"/>
    <dbReference type="OMA" id="AGTHITQ"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="161" mass="16830" checksum="4AEB7D0217DD39D0" modified="2008-01-15" version="1">MSIQKIEGRMIIDSRGNPTVEVDLVTDKGLFRASVPSGASTGIHEAVELRDKDSKSWVGKGVNQAVKNVNDVIAPELIKSGISVTSQKEVDDFLIKLDGTPNKGKLGANAILGVSIAVAKAGAGEKGMPLYKYLSSLANTGSPHIXPAPAMNVINGGLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX78</accession>
    <name>A8PX78_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731171.1">
        <property type="nucleotide sequence ID" value="XM_001731119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX78"/>
    <dbReference type="FunCoup" id="A8PX78">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX78"/>
    <dbReference type="GeneID" id="5855478"/>
    <dbReference type="KEGG" id="mgl:MGL_1354"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1354"/>
    <dbReference type="InParanoid" id="A8PX78"/>
    <dbReference type="OMA" id="RTKAWAV"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="395" mass="44303" checksum="942E72689EC495DF" modified="2008-01-15" version="1">MSTTIKASDVVEKLASAMMQERQQLMENAQASVVASQRIKDLEAVHKTWSAWREQLQCVQDTQRLCETEKDKDMLEMAEQELSQMRDEADARHEALKQQILSNSRSIQSKGAIMELRQGVGGQESCLFLGEMLRMYIKFCETRAQKAQDEDDPSMLGAGWSTDLLSATPVDVSATSGAGDAYREAILQIHGPNAFEALRFEAGVHRVQRIPATQNLGKLQTSTMAIIVLPMQAENDVSKDIVDSKDVRVETMRARGAGGQHVNRTESAVRLTHDPSGITVSMQDSRSQHQNRVKAWDVLRARLLDIHLQKEASENRALRRSQVASAERSERVRTYNFPQDRVTDHRIGISLSDIHRFMDGDDSSGTGLSYLIEELMAREDEIRLHALLESQEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXA5</accession>
    <name>A8PXA5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731198.1">
        <property type="nucleotide sequence ID" value="XM_001731146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXA5"/>
    <dbReference type="STRING" id="425265.A8PXA5"/>
    <dbReference type="GeneID" id="5855505"/>
    <dbReference type="KEGG" id="mgl:MGL_1381"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1381"/>
    <dbReference type="InParanoid" id="A8PXA5"/>
    <dbReference type="OMA" id="HVTCSTI"/>
    <dbReference type="OrthoDB" id="2550823at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="159" mass="17879" checksum="A36518D5B9097082" modified="2008-01-15" version="1">MSHMDINRLSAFNVFWLLHVFLELPVAMLAYIHPYAFPLANVTESTVLIMKLLATFILTSCVGCLLCFMLPDYLPGKRALALQLFLFHGIVAILFWLLPPGIVLYKLPVFVLNLFPLLEQVPNTVFIGSAHAVVSFVGICWWQATIPTVQAFTARLKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXC1</accession>
    <name>A8PXC1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731214.1">
        <property type="nucleotide sequence ID" value="XM_001731162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXC1"/>
    <dbReference type="STRING" id="425265.A8PXC1"/>
    <dbReference type="GeneID" id="5855521"/>
    <dbReference type="KEGG" id="mgl:MGL_1397"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1397"/>
    <dbReference type="InParanoid" id="A8PXC1"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="231" mass="26132" checksum="2983DDD8C6080A9B" modified="2008-01-15" version="1">MVGSEQAASPRNTVLFLLQRAGLMQRDHQTNDKLNITSLGFQFLLQDVNSQLWALLLHYLSMADERNMDLVEVLAFFFTVGGLELGRAYESRGFSQTQLQTLEELSDYGLVYRPSKSAKYFFPTRLASTLTSTASPLLSRLNDQEEQGYLILETNYRVYAYTANLLRIAILNLFVTLKSRLPNLVIGQLTRHSVKSALNKGITADQIITYLTHHAHPQMYKNVSVKVTHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXE8</accession>
    <name>A8PXE8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731241.1">
        <property type="nucleotide sequence ID" value="XM_001731189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXE8"/>
    <dbReference type="STRING" id="425265.A8PXE8"/>
    <dbReference type="GeneID" id="5855548"/>
    <dbReference type="KEGG" id="mgl:MGL_1424"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1424"/>
    <dbReference type="InParanoid" id="A8PXE8"/>
    <dbReference type="OMA" id="SHMAPSY"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="852"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1177" mass="124311" checksum="D2E34EAA9243FA70" modified="2008-01-15" version="1">MSVSEPYAHVSATAAPLTAESKPSWASASTSTAPSAGVTAPFATSAHDSDHPGREYERRPELVQEVTSVSTPTAERATEPVPPLTPSKNGIQRPNKSPYASAYAGMQPTPPKHMYTPSLPQTQVPQVPQPTSQHTPYVPVSPSATPYGQPQPQSQSQAPQRLDSLSAQYPAFPMQGYPPASHLPSRSMAPWQSYASDQGPTTGLGSSQNSALPPPKPNTYSQQQELPYVQPAPMSSQSPAPASHGPMYSRLDGTQPSHQARSPLPMQQTWSYSRSSATPAYSRPGYLPQQVSPASQAPMHARQGPPPQAQGLMSPYGPTPWQRHYPQQHHQPHSPRLPLVPLAPVPPTSSPYLSPVPRAPVLPVHSSQAWPPPSSQPSSPRLPTTQPNYAATPHAPGSHARAAPYGAAYSPMQPPSRPVPTGMPRSVSSPVSSMTSPGYARPLPSQHAQPSHPMPQHQPAYQAPQAHPQSFSPYQQPPPSATPLHLGSPAPASMGYAPAHRGASPTPMSAQRPAMSPPAASPMGTAATDRMTAGLPSTTPYASWMPSSSDMRAQHPSSMPPAAAPTLFQSSKPDSSVQMPHPVSPQLAQLRPGAIVPSGALKNKPLHAPPRAEMLMSPTDREAMGSMMPQVPMHPSFELTQPHPGPLSDPGSDARMQSFPVTVWSESQRAFMSPDPSVGGARNAGSESSSTKQQARHFAGSPTNSMRVGGEYPASQMQQPMLPPPSAAAMNPVTASAMKKAPLGASTNQYLNMNNLPAGDDSGESPPESSASMPMTSAGRIRPAGEAFENRTTMLTVDVLAGGGGNSSGPGSTTGTLSRRSSLNVGSTAGGGRARPSSGDWHGSDFGPARGGGKGTIVLSSHMAPPRKVSSTNVIVQIIAVAIDGVDRALVHERLQGEPTSSPFVPGRSFCGRILDCGIDVKKLRPGDLVFGLQDLRKCGALAEFMTIDKDLVATAPESRLSAEQVAALPATGVMVHQIVQNHCMLLPKGSRVLILNAHDNIGLLAMQEASRLGLVIVAQVPPHTSEGVSICRANGAAEVVSGEPLWTINVLHESSFSLVIDTIGGRQIYDACRRILASQGQFVTCFGDEHSVPSPTYRSHLRSLRRSFFRKDRKAIGYEWIGLDASADCRSALESIKTAAQRGVISPRIQSIIPIDDAPRAFDDSMDAGITVVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXI1</accession>
    <name>A8PXI1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ER-derived vesicles protein ERV14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731269.1">
        <property type="nucleotide sequence ID" value="XM_001731217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXI1"/>
    <dbReference type="FunCoup" id="A8PXI1">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXI1"/>
    <dbReference type="GeneID" id="5855576"/>
    <dbReference type="KEGG" id="mgl:MGL_1452"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1452"/>
    <dbReference type="InParanoid" id="A8PXI1"/>
    <dbReference type="OMA" id="HKKECFI"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15912" checksum="4C0A35D01A49A13E" modified="2008-01-15" version="1">MNGEGWLFLFSILLTAVLLFVMVFYVIMYSDLESDYINPIDLCTKLNQFTLPEMCAHGFLTVLFLLNGQWIALAINLPLLAYNVHKFMNKTYLLDATEIFRTLMTHKKESFLKLGFYLLTFFFYLYRMIMALVAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXJ7</accession>
    <name>A8PXJ7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731280.1">
        <property type="nucleotide sequence ID" value="XM_001731228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXJ7"/>
    <dbReference type="STRING" id="425265.A8PXJ7"/>
    <dbReference type="GeneID" id="5855587"/>
    <dbReference type="KEGG" id="mgl:MGL_1463"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1463"/>
    <dbReference type="InParanoid" id="A8PXJ7"/>
    <dbReference type="OMA" id="KESVQYM"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="97" mass="10623" checksum="DF88B7AF2BC2361D" modified="2008-01-15" version="1">MDKFENQLEDVDVQTSYMENTMSTTTASGMPQDQVDLLLQQVADENGMELHQQLGKAGLAGKVSELPTEMSSARRNAPSADQDEALAQRLRALRPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXS6</accession>
    <name>A8PXS6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731332.1">
        <property type="nucleotide sequence ID" value="XM_001731280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXS6"/>
    <dbReference type="FunCoup" id="A8PXS6">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXS6"/>
    <dbReference type="GeneID" id="5855639"/>
    <dbReference type="KEGG" id="mgl:MGL_1515"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1515"/>
    <dbReference type="InParanoid" id="A8PXS6"/>
    <dbReference type="OMA" id="RKCWWGE"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="50391" checksum="AE5C7DAAB79361D7" modified="2008-01-15" version="1">MADEYESAGDGLATFSRLYLDLRGVCFVIDRETLMSLPESILLCLFPNGLLLPDPNDDISEEKQVYFVDSDPQCLQFVLSFFRRAQEYFYGTDVAAGVYRGAGLSPSYLDLVDPVNGDMMNGFGHPLHLPLFHKQAVILLREELEFFTIPPRSMAKSAAMPDVPPNMPPNATPAFTQLKDACGNALLMRRQIFTALQRNVNKENNMAEQHLIDMLCMSGFEPNDQWGYRAREPARCAITSTALVLLKTGVTQPGELLDGRAPNAPPLQRPIGVHRAGVNMDTGIPVNLTPSPDELGEWVDDGQGGSLCVNQQQLSTTQKLLLFWRKPAVCIYECVGILKCQMLEHTCTDAIFLSSQRKCWWDGIDIVVPQRTMHSEPPTPLPPHVLGTLSPQERSWLDQGIGQCVRVWVRRVWTLEVSLVSNMMGSASPGNLCSHSQAESPRSPCGVRLLAAHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXU1</accession>
    <name>A8PXU1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1525</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731342.1">
        <property type="nucleotide sequence ID" value="XM_001731290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXU1"/>
    <dbReference type="FunCoup" id="A8PXU1">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXU1"/>
    <dbReference type="GeneID" id="5855649"/>
    <dbReference type="KEGG" id="mgl:MGL_1525"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1525"/>
    <dbReference type="InParanoid" id="A8PXU1"/>
    <dbReference type="OMA" id="NVPMTLN"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="173"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="320" mass="34509" checksum="ADAECD39FD73FD25" modified="2008-01-15" version="1">MPLSAMPVELIVGVVALLQGQLRIVQMSLVGSILSNLLLVLGLSFFVGGIYKPENQFAQTAAQASGSIMTLGCFTMVLPAAYWGSVKGGSGDNSVLSALFTRSKEQPVPAPNVGFDAMDGILFISRGTAVILLGIYIGYLVFQLRTHAFLYEAPEHEQIEEQQEEVEMSPKASIIALLVVTIITSFNADYLVSAIDDVANEYSISKVFISTILLPIVGNAAEHVTSVWMASKDKMEIALSVSVGSSVQICLGLVPLLVLVGWFVGQPLTLYFHDFETINLVVSVLLVNSLIQDGKSNYLEGALLVALYLVIALSFWVQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYA4</accession>
    <name>A8PYA4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731440.1">
        <property type="nucleotide sequence ID" value="XM_001731388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYA4"/>
    <dbReference type="FunCoup" id="A8PYA4">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYA4"/>
    <dbReference type="GeneID" id="5855747"/>
    <dbReference type="KEGG" id="mgl:MGL_1623"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1623"/>
    <dbReference type="InParanoid" id="A8PYA4"/>
    <dbReference type="OMA" id="RRTKMNI"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_eL39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="51" mass="6339" checksum="E9761E1A54E5A516" modified="2008-01-15" version="1">MPSHKTFRTKVKLAKAARQNRSIPNWFRMKTDNKIQYNKNRRHWRRTKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ33</accession>
    <name>A8PZ33_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730885.1">
        <property type="nucleotide sequence ID" value="XM_001730833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ33"/>
    <dbReference type="STRING" id="425265.A8PZ33"/>
    <dbReference type="GeneID" id="5855192"/>
    <dbReference type="KEGG" id="mgl:MGL_1884"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1884"/>
    <dbReference type="InParanoid" id="A8PZ33"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="209" mass="23193" checksum="9F49B151CB837868" modified="2008-01-15" version="1">MQNGFRVAVADSDELLLAAYELRINVFQDEQGYERDIDSLDRTAVPMVLIRACDEKVVGVLRILSWPVPTSHATYDTAESLTSVDIPGRGRSHADMQAAFMQHQTTSVQDDTCWYSGAKLGRIAVSKDSRGQGCGRLLVEGAQAWVVQAVRQHASVPAEVHRLGIVFQLSSQIEVQPFYESLGFQVQGDSYMEEGHPHIWCKKSVLTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZV0</accession>
    <name>A8PZV0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730953.1">
        <property type="nucleotide sequence ID" value="XM_001730901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZV0"/>
    <dbReference type="FunCoup" id="A8PZV0">
        <property type="interactions" value="877"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZV0"/>
    <dbReference type="GeneID" id="5855260"/>
    <dbReference type="KEGG" id="mgl:MGL_1952"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1952"/>
    <dbReference type="InParanoid" id="A8PZV0"/>
    <dbReference type="OMA" id="ITKAQPV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="125"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="655" mass="75152" checksum="60AD0246BABEE71D" modified="2008-01-15" version="1">MSLWTGFTLYVSQDTYTFVPNKSEPGRQANKLVIDRHENALRLEPVVLGSEVPKHEKQFIVHGILGIISLHTSEFLVVITNRKRVAHILNSTIYLATDFRMLPVRSDANPAMLSHPIEKRLLSLVKESLYSGPLYFSYEFDLTSNLQRQVQQSASSMGAGVPLWKRADERFFWNAHLQGRFVKHSERYPNEDLSPFIMPVMFGFLEVKLARIENRSFVLGLIARRSRHRAGTRYFSRGVDDSGNVSNFNETEQFVLLDPPSLQPPQEIEDIEGLIRMSFVQTRGSVPVYWAEINNLRYKPDLLIPDDPRTLTSFEKHMSKQVSIYGKNYLVNLVNQKGYEKPVKEAYEGAVKFLDHPLVNYTYFDFHHECKGMKFDRVSRLVEHLENEGLTSHDFFSLDTVAAPRLQLQKSVVRTNCMDCLDRTNVVQTTLARWVLNDQLRSVGILQPNDCVENHPKFISLFRNIWSDHADVISKAYSGTGALKTDYTRTGKRSMEGILQDGINSLTRYTKNNFFDGQRQDAYDLITGAWDPQSDMPFVDTRPWGVRLMPWLLYLSIFFVLASVLLPGGEPLRPYRIDTGSVPTFAILWGLVALYAIYFIWQHGVEYVGWPQLNRPEHLIHYTGPGYYSSLRGRAGTPCDPKLLKKQQVAAKKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0Q1</accession>
    <name>A8Q0Q1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731066.1">
        <property type="nucleotide sequence ID" value="XM_001731014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0Q1"/>
    <dbReference type="FunCoup" id="A8Q0Q1">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0Q1"/>
    <dbReference type="GeneID" id="5855373"/>
    <dbReference type="KEGG" id="mgl:MGL_2065"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2065"/>
    <dbReference type="InParanoid" id="A8Q0Q1"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="435" mass="49808" checksum="5A9AB3136CB832E2" modified="2008-01-15" version="1">MRDRTHAILLNEHWQLQVQADQSPDARLADVCGNDKFLSATGECLPRLAMPPPVPMTDLEFRRSIEAKIALEVERLPIIDKRTVQFFGKWPQLRVLGMQEPMSVLFSIANLLVQVYAISRMFPEKLPTTFPLKRVYVANATVASVAWIASTVFHARDLWWTERWDYFSAAAMLMSGLFLAICRIFRIQPGSLVFRRLLMGCVGTWVVHVLYLLSHRRLDYTYNMAACLFVGFVHNILWIVYAHAPQLILRLREYVRLSFDQGRQAPVKPETASDSKQTQFALPLSARRQLELLVILTFAAPALELFDFPPLFRLLDAHALWHLATVPLTLCWYRWLLEDARQCVMMHAWYLDHHGMDVTDIDELQDTRPHGELPASALALPVSMPHVLAADSMLSTPQMSSALSAQISSMHNLLISLKLWGWNMLRSLRDMFISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0V9</accession>
    <name>A8Q0V9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731090.1">
        <property type="nucleotide sequence ID" value="XM_001731038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0V9"/>
    <dbReference type="FunCoup" id="A8Q0V9">
        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0V9"/>
    <dbReference type="GeneID" id="5855397"/>
    <dbReference type="KEGG" id="mgl:MGL_2089"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2089"/>
    <dbReference type="InParanoid" id="A8Q0V9"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="216" mass="24025" checksum="54251EB07003C903" modified="2008-01-15" version="1">MRQYKSVGEELWRQNPNKVNSELFSLTYGALVVQLIKDFEDYEQVNIQLEKMGYNIGTRIIEDFLARTNLPRCTDIREMAEVVSKVGFKMFLNITPAVSFLAPSASTPSASADGASMLKTASSDTASAEGKSTSQEFVLQLAENPLAEFVELPEEALHGGLWYSNVLTGVLRGALEMVQIQTECNFVTDVLRGDETTEIRVKFLRFLDEEAPPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q115</accession>
    <name>A8Q115_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731113.1">
        <property type="nucleotide sequence ID" value="XM_001731061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q115"/>
    <dbReference type="STRING" id="425265.A8Q115"/>
    <dbReference type="GeneID" id="5855420"/>
    <dbReference type="KEGG" id="mgl:MGL_2112"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2112"/>
    <dbReference type="InParanoid" id="A8Q115"/>
    <dbReference type="OMA" id="IHSRKYQ"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058535">
        <property type="entry name" value="MafB19-deam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="58" mass="6440" checksum="8D981FA739271A10" modified="2008-01-15" version="1">MLTTTLYVTIEPCLMCASALRQIGIQRVVFGAGNERFGGNGTVLPIHSRKYQRYAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q117</accession>
    <name>A8Q117_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731114.1">
        <property type="nucleotide sequence ID" value="XM_001731062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q117"/>
    <dbReference type="FunCoup" id="A8Q117">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q117"/>
    <dbReference type="GeneID" id="5855421"/>
    <dbReference type="KEGG" id="mgl:MGL_2113"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2113"/>
    <dbReference type="InParanoid" id="A8Q117"/>
    <dbReference type="OMA" id="GLWSTHR"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19518">
        <property type="entry name" value="RecA-like_NVL_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="127"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="474"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="737" mass="80605" checksum="3C22B9E385D7FE22" modified="2008-01-15" version="1">MNAAITGAWSKQRTRISLNGTPPTGSAAAAAAQSRAECKQEGLENTPGEVAPSDKKDKSMKRKARSSREQVSKRGKMKSLSADDKYAAPPTRLRDIGGMAAAIEKALELVAMPLCHPEIYLHTGVTPPRGVLFHGPPGCGKTMMAGALAGELGVPFLSVSAPSIVSGTSGESEKALRDTFDEAKSIAPCILFVDEIDAITPKRETAQREMERRIVAQLLTCLDELAWEREEGQPVMVLGATNRPDAIDPALRRAGRFDHEISLGVPDEHGREQILQVLCAKLRLAGDFNVKYLAKRTPGYVGADLTSLTAAAGIIAVKRIFQYLHDTQESMQCDDEAPIEYKQVATKTQVSNEDQESEVERKLIKEEEGRILAGPGFLEGLPDSVQSSSIAMFLKRFVNPLSNEQLEHLAITNDDFLEALKVVQPSSKREGFATVPDVTWDDIGALHQIREELSMAVVQPIRRPELFRSLGISASCGVLLWGPPGCGKTLLAKAVANESRANFISVKGPELLNKYVGESEKAVRQVFARARASSPCVIFFDELDALVPRRDDTLSEASARVVNTLLTELDGLESRVQTYVIAATNRPDMIDPAMCRPGRLDRLLYVDLPSPDERLDILQALTKMSPLATSTDPQDLEHQPVRLELIAHDHRADGYSGADLASLVREAAVTALREKIVSPLQYTDDSEPVERVLVYQNHFVHAFDRVQPSVTPEQRLKYEALRSRIASGSTRSGQALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1L4</accession>
    <name>A8Q1L4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="7">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1806</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730807.1">
        <property type="nucleotide sequence ID" value="XM_001730755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1L4"/>
    <dbReference type="FunCoup" id="A8Q1L4">
        <property type="interactions" value="640"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1L4"/>
    <dbReference type="GeneID" id="5855114"/>
    <dbReference type="KEGG" id="mgl:MGL_1806"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1806"/>
    <dbReference type="InParanoid" id="A8Q1L4"/>
    <dbReference type="OMA" id="QDRGDTF"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="10">
        <location>
            <begin position="210"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="9">
        <location>
            <begin position="499"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="692" mass="79000" checksum="128041B1019070B3" modified="2008-01-15" version="1">MSAGDNVAHVRLMTLLNVKNVHPREEDRPKAAERAHVYPKQGASSLSKRKRDAAPVSAPAEKHTKAEQGTASHASELHQQRMIPVIVANEEEDDDDGDENHGPSRLKSQDNSNENASIQVSDQQDAFHWHFDAESKALQGIDPEHLVWGQPEPVPQFGGAQLVRIHREASSQVPHSRPVSRPHARIWRAFSGKTEPTALQIEFLQYLGEYMDVWHSRVTIPEHAPLRQVTAMHAMSHLAKTRQRILKDNERLAKAVAAQVENDKADQDSVGDDELPEFRDQGFTRPKVLVLAPFRHTAKVWIESMIACSGCEQVEQKARFEREFSLPPGSIDKLADPESAHRYPEDHRHTFQGNIDDNFKLGVKLTRKTLRLYSAFYESDLIMTSPLGLRLLIEKDHDSDYLSSLEIVIADQLDVMLMQNWEHVKFVWERLSVIPKEAHDTDFSRVKPWYLDGQAPLLRQSILFSSLDAPEFRHLFHSLQNVGGRLRTTSLDEHHVPSMSLVTPGVRQTFFRFECSSAQSEADLRLLAFKDRIMSLLKKSAVTTSHTMIVVPSFFDFVRVEDYFRKLDPPISYTTLSEYSSTRDISRAREAFFSGKKSVLLLSERFHYYRRYIVRGAMTVIFYAPPEHATFYAELTNAPLTSRYETQAVVDAGDLQVWTLFCKYDLLRLERIAGAQQARHMLTGMNASYHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q244</accession>
    <name>A8Q244_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 11">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_2129</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 11"/>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730675.1">
        <property type="nucleotide sequence ID" value="XM_001730623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q244"/>
    <dbReference type="FunCoup" id="A8Q244">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q244"/>
    <dbReference type="GeneID" id="5855001"/>
    <dbReference type="KEGG" id="mgl:MGL_2129"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2129"/>
    <dbReference type="InParanoid" id="A8Q244"/>
    <dbReference type="OMA" id="WTCDAND"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="17">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="201"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="13">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="13">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="232"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="14">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP43461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="421" mass="48542" checksum="DBD527BE45EA7A28" modified="2008-01-15" version="1">MSSKWTSHANEATCLYLAGAPSRCDRVFHPAFTYPIFGDAETIYGYERLHIQLSFASGSLRPSLNIEYRAKNTMTTAKVDDVDKQLREFLPEADLVSPDAFPQLVQADAASFQPPGTQITSYTQRAKGQASDRTFCIFHSTWDTPGFRAWLKRAQIFTLFFIEGASYLEEEEKNWEFFTIFERAHAPSTQQQSDQHHATWHFVGYTALYRFWCWPDKTRWRLSQFLILPPYQGQRHGTHLYDTVYAHALSDPAICELTVEDPSEAFDKLRDTCDLTYLNQQNDVVHHIAAPMDRAWRSNARLRYKLAPRQWARLLDMLGLLHLDPGASPDQFRAFRLQVKARIYQQNREVLDMLPHEQRVEKLHETFEAVLDEYADITGVEVPEALLEMSPSPQPKRIPSSLNDDDHSEGSSVPRKTPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q246</accession>
    <name>A8Q246_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730677.1">
        <property type="nucleotide sequence ID" value="XM_001730625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q246"/>
    <dbReference type="FunCoup" id="A8Q246">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q246"/>
    <dbReference type="GeneID" id="5855002"/>
    <dbReference type="KEGG" id="mgl:MGL_2131"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2131"/>
    <dbReference type="InParanoid" id="A8Q246"/>
    <dbReference type="OMA" id="YPPPKVA"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="251" mass="28122" checksum="E7BD91B3F75ACC72" modified="2008-01-15" version="1">MSQINKACCSIPPVKTDYQPQGRMEKCADMDAYVIGPADSKTVLVCVYDMFGFWDTTKQCADLLSEVMKVKVVMPDLLRGNPWPIDHFPPRNDEEGKKLSEWFSSIASMPERSKDLKNVAADLKEKGAEKLGLYGFCWGGSVASLAGKAGTPYLGVSIIHPPIVAPEDSKELSVPVAFFPSKDEPRDECDKYWDTLKSSHPELIEKSVYHYYGDMFHGFASARANLKDKANYDAAVDVYQRLANFFCYVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q292</accession>
    <name>A8Q292_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2171</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730717.1">
        <property type="nucleotide sequence ID" value="XM_001730665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q292"/>
    <dbReference type="FunCoup" id="A8Q292">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q292"/>
    <dbReference type="GeneID" id="5855023"/>
    <dbReference type="KEGG" id="mgl:MGL_2171"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2171"/>
    <dbReference type="InParanoid" id="A8Q292"/>
    <dbReference type="OMA" id="YGICTTA"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="136" mass="15420" checksum="8C61017DF91DA7A8" modified="2008-01-15" version="1">MILAAVGSGSYFMTLDIDPSQTIAGIDPMFVYLGATLTCTGLGWLIGPSFGSTAWSLLHRRQASRMAQRDKQFFDHIRKMRADPTRQVVHNPLPDYYGEKIGSLREYRHWLRKQCSMFSPKRKKKRAGSTGHVIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q311</accession>
    <name>A8Q311_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730491.1">
        <property type="nucleotide sequence ID" value="XM_001730439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q311"/>
    <dbReference type="FunCoup" id="A8Q311">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q311"/>
    <dbReference type="GeneID" id="5854798"/>
    <dbReference type="KEGG" id="mgl:MGL_2287"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2287"/>
    <dbReference type="InParanoid" id="A8Q311"/>
    <dbReference type="OMA" id="WRIYEAN"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08029">
        <property type="entry name" value="LA_like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="114"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29258" checksum="30A90B74453AAB5A" modified="2008-01-15" version="1">MTQDEGAGASATRAPMSIDEAKSAVLKQVEFYFADANLPFDKFLFTLTRKDPEGWVPIDTIASFKRMKPMREVLSSQDIAEALRGSTSLLEVDSDGKRVRRKAEMKPVPDAHARSIYAKGFPDEFDGLQEELESFFAQFGKINGVRMRRENEKPRKFKNSVFVEFADAAEMRAFLEKAKATEPQEDGGHGIEYKGAKLVTMSKPAYVEMKMKEKGIDPNNNSSSKSSSSKGGRKFNAFREMERERRAYTWTGCFEELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q351</accession>
    <name>A8Q351_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730516.1">
        <property type="nucleotide sequence ID" value="XM_001730464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q351"/>
    <dbReference type="FunCoup" id="A8Q351">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q351"/>
    <dbReference type="GeneID" id="5854823"/>
    <dbReference type="KEGG" id="mgl:MGL_2312"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2312"/>
    <dbReference type="InParanoid" id="A8Q351"/>
    <dbReference type="OMA" id="TIAMYEY"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="32150" checksum="03222412AFDC8FF6" modified="2008-01-15" version="1">MTRAPVYFGLVPKEHWSYPSWIDQEKAAREREKMGEQGIIYGDSESYRHMCRFQSGFFFEHPLTYELGLEYYWRVEPGVHLTCDVDFDPFVFMQLNNKAYGFTISVHEFEDTIKSLWPETIKFVLKHPEYIAPDNARHFVLQEERDFAETEYNLCHFWSNFEIGDLRFFRGKQYKEYFDHLDKAGGFFYERWGDAPVHSIAAALFLNRSQIYHFEDIGYYHAPWGHCPYNREKFHNNGKCSCNPEESFDRDGWSCTALWWETSYEGDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3N3</accession>
    <name>A8Q3N3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730659.1">
        <property type="nucleotide sequence ID" value="XM_001730607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3N3"/>
    <dbReference type="GeneID" id="5854966"/>
    <dbReference type="KEGG" id="mgl:MGL_2455"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2455"/>
    <dbReference type="InParanoid" id="A8Q3N3"/>
    <dbReference type="OMA" id="HEHDAVS"/>
    <dbReference type="OrthoDB" id="2532734at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="69" mass="7625" checksum="7FEFE789C81780B9" modified="2008-01-15" version="1">MSSQDTSFHIQPHPAKDNNPRADSHEHDAVSGAIHAPPGIQKLDEQTASQLEAPKSDEELQKRSEELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3P2</accession>
    <name>A8Q3P2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2462</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730666.1">
        <property type="nucleotide sequence ID" value="XM_001730614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3P2"/>
    <dbReference type="FunCoup" id="A8Q3P2">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3P2"/>
    <dbReference type="GeneID" id="5854973"/>
    <dbReference type="KEGG" id="mgl:MGL_2462"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2462"/>
    <dbReference type="InParanoid" id="A8Q3P2"/>
    <dbReference type="OMA" id="QPKGDHV"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="487" mass="53564" checksum="AFC9D050B4E7EBC0" modified="2008-01-15" version="1">MVRDVFEPSNIANLVGTMGVGHVRYPTAGSFAHAEAQPFYVNSPYGIVLAHNGNTVNQDQLRTMLDSEAHRHVNTDSDSELLLNLFAHHLQRTGKFRINEDDIFTALQAMMKEAVGAYTCVATLAGFGIIAFRDPHGIRPLGMCKRKSQTPQSEGHGYDYCFASESVVADSLGYEDFEDINPGEAVIVTPKNVTRRKLVTMPAPNTFTPDIFEYVYFARPDSVIDGVSVYRSRMAMGDSLAKQVEAELLAKGERIDVVIPVPDTSRVAALQLAQTLQIPYREGFVKNRYIGRTFIMPGQSSRRKNVRRKLNAMALEFSGKSVLLVDDSIVRGTTSREIIQMARDVGAKKVFMASCAPPIRHSNVYGIDMPSRSELVAHDRSVEEIAKTIQADAVIYQSLEQLVEAVRSLNPAITKFDCSIFNGEYVTGGVDEAYLSTLEKARADHEQAKKAAQQLMTTSQSTSESVLSCSGPMNGAGDIALHNGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3Z4</accession>
    <name>A8Q3Z4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2482</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730100.1">
        <property type="nucleotide sequence ID" value="XM_001730048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3Z4"/>
    <dbReference type="FunCoup" id="A8Q3Z4">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3Z4"/>
    <dbReference type="GeneID" id="5854402"/>
    <dbReference type="KEGG" id="mgl:MGL_2482"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2482"/>
    <dbReference type="InParanoid" id="A8Q3Z4"/>
    <dbReference type="OMA" id="AWISCET"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15552">
        <property type="entry name" value="PHD_PHF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21538">
        <property type="entry name" value="SPOC_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="11">
        <location>
            <begin position="211"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="858"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="358"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="786"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="899" mass="96356" checksum="5BEF809D3A8CD590" modified="2008-01-15" version="1">MPDSTAHAVSRKRGHRGSQGHDAAKRTRASKSVNNEAEAEGVKEEGGEVGDNDEDEDDDEDNSVYCICRQGNDGSPMICCSHCGEWYHFRCVGLSKRAADQIQEYVCDECNKAEQAPQKQAEQDPEYQHPENEKGEEDEHYNHRSMDADARIELAGDDAVDPQPSSDGVDDDASDQGTATHSRAGSHKYRRSTSSSTKNAARTTVSGQDPVRKHVLTTFTSIFEPLFSAKNAEPTKPHEYASQLEAELFRVYGQDPALRAYKEKFRSLLFNVKDHRNTSLHERITSGNLPAADIVHMSNEALANDTIREATEKAKRDALHQAVLRDQANGPARKITHKGEVDIERDASMSFAPGDMGLSTSTTIHTGPEPSTSSTNEHVTLSAPGSASVASDTSGSNDSFEKPNVAASTHRSDQSDQRVPISPSRTPSQDGTDVLVPPEPISFSGVWDTSQRQQHTETSTNSNYDIEPTNFAAADGSSEFGLEADAQADTCIDSFLDHEQPEAASEAHTPPGTPPPDAFVVRASQAASKSPIDHCPVVWDGVITMPEYTSAYVHARQLTEPTFAVDAPAWQDFFPTQERVVEGRLPSQTAIDYLLQVRLSPRNTMVVLLVDAGGATAASERHTSTVSTLHGSPALDKLVHYFADKQRFGVLTPAPGAQGSLVKDFYIAPLLSHMPVPEWLKQIHPEGLGKAWDAQRPANVLLVVLVLFKSALEGRTKVVDTPSAPPHPRSIEQSVQPVSLDALLNVKPDAIQNLLSTLSGSASPGTTAVPPVVPAMPGVPLGAPSPLTPPGPAPISSPPGPVSGAPPLARPMRPWGGVVRDQTPSSHGYVTPIQPGLLPVGGTAVPPPMDMGFRPFPVGPGGWYGGNVDRTKDKSRRRGGDRGGGGSVSSGSRRGGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q447</accession>
    <name>A8Q447_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730115.1">
        <property type="nucleotide sequence ID" value="XM_001730063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q447"/>
    <dbReference type="STRING" id="425265.A8Q447"/>
    <dbReference type="GeneID" id="5854422"/>
    <dbReference type="KEGG" id="mgl:MGL_2497"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2497"/>
    <dbReference type="InParanoid" id="A8Q447"/>
    <dbReference type="OMA" id="CNAWLSQ"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="853" mass="90579" checksum="02BA31BCDF6E9C9F" modified="2008-01-15" version="1">MTTAATEPAGVAAPAASGSSSSARHSAAAPLLHTPIQLCTYAQPRPSQHTATYELCNASARTTRHSHVAVGDVVRLSSRGALGSVRRRRGLVALLEQGTAIVLMDLQTQTPVHTHTLAPSDHVCTPPLVVERSLYVPAKQPVRTTYVGVQATSEHTEVRAYTEILDSRGKHIPAHAPGSADPNGSRNGASSGVGMDMGHQTVGTVPGTLCALYALGNGQLLATRKDGAVLLLADPIAAQSVRVLATYDSGNMLLHHVCLLDSNDARTLLPHEHDAARPLLGALALAASASPTSTDVLVHIVGVHTDSLHAQTCMLPAEQDIMSCALEPHGRLHVLTSGQKLLSARFHAVDARLVIDEPSALQLPPVDDASLVCLSASHLLAVVLRTEHGRTRASALLWDMDLDAVVATVEWSVALSGPARISATRAMDDYVLVQVDPYASSESKCSVVALPVSVPTTGLLRHALGAAARTAPWLVSPETSSVRSPDSCSTHASGSPRARALLDRLQGLPTHDAAARAKALDAHVLAWLEAESDALREATQTKAGRKAPKVPLDAALVQQVMDMALPALPGTSASALASSGTSMQAGRVSSRSAVALPYAREAVRYFVERGAVSTSLLPDLVPRARLTHDWSLVFLLLRHVPDLSEAQALTFLHDALRAAADSDPQAPAIPRVLQHILLPPAFSKPALRVALRTHITDDADVLILLDILNTWIDLHMASAWDSSSVHRMKDEVRTLPLSSATAASKPSLSYRTGGVQPARFDACLSFMEDLIDTFFPQWLGATAMHPFLRECTRSLSTHAHTLQMVSRLRAPLEGLISSAQQAESGDDAQRSRRLALHEASLLVPAYSKEVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4C1</accession>
    <name>A8Q4C1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2522</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730140.1">
        <property type="nucleotide sequence ID" value="XM_001730088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4C1"/>
    <dbReference type="FunCoup" id="A8Q4C1">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4C1"/>
    <dbReference type="GeneID" id="5854447"/>
    <dbReference type="KEGG" id="mgl:MGL_2522"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2522"/>
    <dbReference type="InParanoid" id="A8Q4C1"/>
    <dbReference type="OMA" id="FRMNLAD"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="176"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="253" mass="28435" checksum="D628E2B5042470C7" modified="2008-01-15" version="1">MASEHDADAMDVSAEAPVVPPASTTVLDFSDLDASIQSFTRRFDHYVQTTIASCDEARLAADAQRTEIQERVRALEREREDTKHAQKELWENVASERDADAKLRASVQNLMAQREALVQRTAGIRKEVSEIRAQMEARKQHKQMQVQRLREQVRRNAPELAQLERLTGCTISPSVRAGTIDFAFSLISRDNPARSATLSLDVSKTQYKVPTYDSILSAATVKALLQELERTGDVYTFLKRARSAMVDSLAREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4D0</accession>
    <name>A8Q4D0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2525</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730143.1">
        <property type="nucleotide sequence ID" value="XM_001730091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4D0"/>
    <dbReference type="STRING" id="425265.A8Q4D0"/>
    <dbReference type="GeneID" id="5854450"/>
    <dbReference type="KEGG" id="mgl:MGL_2525"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2525"/>
    <dbReference type="InParanoid" id="A8Q4D0"/>
    <dbReference type="OMA" id="RTTYQPN"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase HACE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="227"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="562" mass="64303" checksum="280C45CEF7437D5D" modified="2008-01-15" version="1">METSSDGLAEMLSRLQSGGANPFTLLMPDAGAIPVTSLRRQRSSSQESAQGDESTKNVSAEEKREGEEKLARVYESFDFDALWTRLSEALTRLRRDPGSAQVLLPMIESLMVVSQHVMGTYAPEDAPLESVTSAPGTRRAQMEADFLVFTEKHRKILNLMVRQNPALMSGSFSLLVRNPKVLDFDNKRNYFSQQLHKGRREHYTPLSLTVRRQHVFYDSFQYFNRKSGPEIKHGKLNVRFHHEEGVDAGGVTREWFQVLSREMFNPDYALFQPCAADRTTYQPNRMSSVNDMHLAFFKFIGRVIGKAIYDGRLLDAYFTRSFYKHILGRKVDYKDLEAVDPEYYNSIEWMLHNDITDVLELTFSVDEDVFGETRVVELKPGGASIPVTEANKHEYVRLVTEQRLTNSIRSQIDAFLDGFHEVIPHSLIQLFSEQELELLISGLPDIDVDEWKNHTELQGYKSSDPVIQWWWRAVRSFDQTEKAKLLQFITGTSKVPLEGFAHLQGVNGTQRFNIHRAYGEDRLPAAHTCFNQLDLPAYDSYEKLRSQLLLAMNEGSEGFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4F7</accession>
    <name>A8Q4F7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730153.1">
        <property type="nucleotide sequence ID" value="XM_001730101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4F7"/>
    <dbReference type="FunCoup" id="A8Q4F7">
        <property type="interactions" value="646"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4F7"/>
    <dbReference type="GeneID" id="5854460"/>
    <dbReference type="KEGG" id="mgl:MGL_2535"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2535"/>
    <dbReference type="InParanoid" id="A8Q4F7"/>
    <dbReference type="OMA" id="QENYLHY"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="154"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="795"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="805"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="850" mass="94103" checksum="3E11376307C5742A" modified="2008-01-15" version="1">MGASRFPLPLALYVFSSTATRRGEGQWVWPVFVPDTHTSITRPRLLSFRASWQVVGREKEKERERKRERERESVCVCVCQTSAPYITTVCTSAPFFLLRTMDARKRSATTKTGSSKRVKAEENDSPSNVPVWKQMAQRRAAGPVAPGSKAIPEGAPNCLAGLTLVFTGELSSISREDAIDLAKRYGAKVTTAPSSKTSYVVLGDGAGAKKLETIQKNKLKTVDEDGFLALIAERGARELDPNVKQKIQAEEKKVVAAAKALDTPNVPGQLWTSKYAPKQLRELIGNKAQVDKLQAWLRDWPKSRKAHFKKPGPHATNTFRAMLISGAPGIGKTTAVHLVCALEGYETLELNASDTRSKKLLESELSDTIHNRSIAGWTHKQQPNVSTSGPDTKHDRLAIILDEVDGMSGGDRGGIGAINALIRKTQVPIICICNDRRHPKMQPLLATTFNMTFSKPTVQAIRSRMLSIAFREGLQIPAEVMDQLIIAAQSDLRLVTNMLSTWKLSHASMSFDQSKSFGALHQKPTMHTPFSLYGELMSPQRFGPLNKQSLNDKLDFYFQDHSIVPLMVEENYLKSQPLSVQKESTPPLRDWKHLELLSKAAHSISDGDLIDTMMRGPQQHWSLLPLHGIASTIRPCSLTYGGHSSFPAFPAFLGQNSKRLRLQRQLVDLQTHLRLRTTGSKDDVRQSYVPGLLSLVVDPVLQHAQAGIQDAIHNMDEYFLLPDDRETLVELELGDQRREDRLKKLPAAVKSAFTRAYNASSHPVAFQPSSSSAPKVRALKGEALPDNEEAYGVRWSLDSSRTGTDDDDNVEQVDEEPMDDADDATADSKDDDDVAKVRSYVPPRLVALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4J6</accession>
    <name>A8Q4J6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730168.1">
        <property type="nucleotide sequence ID" value="XM_001730116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4J6"/>
    <dbReference type="FunCoup" id="A8Q4J6">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4J6"/>
    <dbReference type="GeneID" id="5854475"/>
    <dbReference type="KEGG" id="mgl:MGL_2550"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2550"/>
    <dbReference type="InParanoid" id="A8Q4J6"/>
    <dbReference type="OMA" id="PHEEFRN"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="45"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="452" mass="51647" checksum="D9FBBD8ECAB2B38C" modified="2008-01-15" version="1">MLMYFEECSDESEDDLYAGRDEESIERLEEEISQLNDTIDGIEAYHIVDKLGEGTFSSVYKAIDIHHEMYANAEWFKSNTPYIKPRERSRGGTVYVALKRIYVTSSTARILNELEIMESLRGEPYISYLITAFRSADQVMVVMPYTRHSEFRDYYRIMPLSDFPCYFYCLFSALEAMHRQGIVHRDIKPANFLYDPRTGYGTLCDFGLAERLDASEWHGKCHHTLPSPEHPHGEQCINYTTQSTHIQPGGALARSEDGGKSSSYVSRMAPMGPPDRVGYLRNDPRPSIRANRAGTRGFRAPEVLLKCPDQTPAIDIWSAGIVLLSFLLRRFPLFNANDDTEALLELAAIFGQRRMEQCAMLHNRTFSCNLPTVNHSGRRIPELIQQFRPDLFEPPDGCPEPSDYRQQVQYVVHLASVCLYLDCTRRWPASRILQHAFFQDVAISPDAELSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4L9</accession>
    <name>A8Q4L9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730188.1">
        <property type="nucleotide sequence ID" value="XM_001730136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4L9"/>
    <dbReference type="GeneID" id="5854495"/>
    <dbReference type="KEGG" id="mgl:MGL_2570"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2570"/>
    <dbReference type="InParanoid" id="A8Q4L9"/>
    <dbReference type="OMA" id="HQERETS"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="63399" checksum="A8A3D8FEB0A1E4B3" modified="2008-01-15" version="1">MDVPLAVGIGLIASFVQSLGITIQRRSHIQNERLPESQRQPEWLRPLWVIGFVIFLGANISGTLFQIGTLPVVILAPLGAVSLLYNALLARVMLDAFFSWHMLTGTCLIAIGAVLIGYFGTVPHSPRTLDELIALYERPAFVALAVLYLLVFVSLLTMAHLTEWQLTWHSVQAFQRRAYRRRPRFGLRRYLPVPSLATVAEVSENSSGITSPLLQNTEDDRVDKLLSGDVRAIKHMRGTLPENPASSSSSSSAHSQYGAISNPDGAFHAKDVPETTRKSRPSLMTSRSAPTLPVSSAAAGTRSSLYDSPSLRPTVLALAVVYSSASGTLSGICLLMAKSGVDLLILSLQGRNQFGHWKSWLLAIALLIAALLQLWYLHKSLKLADPVLIAPLAFCFYNISSITLGLVYFDDLSRLSWLSVLMVTTGTVLLLWGVWIISLHKQSSTEMTSDPTGAVQASSSHAGDRTSCSGHVEAPPPSFLVPSLKLYVHRRMHSSAAQLGIRTRSSSSISLDHTPPFGTDHAHESPSTHRTSWFAMLAERGLSVGLSPSSPGFHVQPHLPHHRMSTPSSALRHDIEEQHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4P8</accession>
    <name>A8Q4P8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730217.1">
        <property type="nucleotide sequence ID" value="XM_001730165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4P8"/>
    <dbReference type="FunCoup" id="A8Q4P8">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4P8"/>
    <dbReference type="GeneID" id="5854522"/>
    <dbReference type="KEGG" id="mgl:MGL_2599"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2599"/>
    <dbReference type="InParanoid" id="A8Q4P8"/>
    <dbReference type="OMA" id="PFTRPHT"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="770"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="820"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="875" mass="96511" checksum="D3B493332065C6FB" modified="2008-01-15" version="1">MQYMAAVMRMFDILEQNVTKVDKIEKPREPEPGMETAYLLCATTHNVERIIEDMTPTRTRPPLYDAAHVFFVDAVSDELVEKLTRSKAGPKLKQLVELFINMWPTESQTFMLKHPSSFFTVFQPMDTKFSPSMDEALALMQDELDMSTQAILNVCVTLNENPLIRYLHTPGKILGPLSPEALSDTIEGTFAADDARISDVPGRIQIGVPFTQQLAHRVQAALDDYSKNQMLGDPGRPRGVLFITDRTMDLVSPYLHEFTYQAMVYDLVQIHDNTYKHTYVNSEGAREELVVELNDEDEIWTSIRHLHIAEAIVYLTREFQQHMGEASQFSDSMSISGMRDMLTALPHMQQTKEKLSVHLALAQLCMDKFERSKLSAQAMVEQNAATGQTPEGSRPRSLVEEMVPILDDPSITNSDKVRIIALYILYSDGVQDEDRRRLFQHARLTGGETASITNLSLLGARVTREPSTSSLDAIFRKRRKTLAPRLPAAGQSEYELSRWQPLLRTMLEDHLLGRLEQAMFPYVRDAPPEQPFSAQLQQRSMSFSASASDMATSMLHSAINATGGKDSPLARVGAGFGFDQSSSTRAQTLRGGGTTSLRSARPTWHQKGRSQSAASIAAPAGAGSSTAAGAGGTLGSQRAPSTVLEEMSNPSAQRLIVFMVGGVTYSEMRTAYQVGKRNNAEVYLGSSHVFTPLSYMDSLRVIGTPRQPVPPDLHVEARRRAQEAEREQLLAQQQGKKVKNAPPLKKPQYPQELWPQARYDLRFTTEDEVPSATAATATPADTPAAPPPMPEKSANRLARLKKGGKDVSMGASASSPAKYDSAPPNSDSPDPSNAAAGAVPAAPTSVAAPDPPISTSRNRWGRDMSKFKHALFHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Y0</accession>
    <name>A8Q4Y0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2669</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730287.1">
        <property type="nucleotide sequence ID" value="XM_001730235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Y0"/>
    <dbReference type="FunCoup" id="A8Q4Y0">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4Y0"/>
    <dbReference type="GeneID" id="5854592"/>
    <dbReference type="KEGG" id="mgl:MGL_2669"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2669"/>
    <dbReference type="InParanoid" id="A8Q4Y0"/>
    <dbReference type="OMA" id="CCGGCVI"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24291" checksum="E240343798EAA32F" modified="2008-01-15" version="1">MSKAKFLREYKLVVVGGGGVGKSALTIQFSQNHFVDEYDPTIEDSYRKQCMIDNEVALLDVLDTAGQEEYSAMREQYMRSGEGFLLVYSITSRSSFAEIATFHRQVLRVKDRDYFPMVMVANKCDLESERQVSTAEGYAMARSIGCPFVETSAKQRVNVDEAFNDLVREIRRFMREETSYRGVSSQEVPGENGILAADSLRDSGVDKSCCKGCVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q551</accession>
    <name>A8Q551_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730342.1">
        <property type="nucleotide sequence ID" value="XM_001730290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q551"/>
    <dbReference type="GeneID" id="5854647"/>
    <dbReference type="KEGG" id="mgl:MGL_2724"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2724"/>
    <dbReference type="InParanoid" id="A8Q551"/>
    <dbReference type="OMA" id="WANHLME"/>
    <dbReference type="OrthoDB" id="3363153at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="410" mass="46108" checksum="B1356EDAE80143A9" modified="2008-01-15" version="1">MGSTLHNAESNTSDVGHSAQNAEATATAVTPVEDVRVALRLAALNSLKSRTLSKRVQRSSEPKTISGNLSLTNTETQNVQPATVESNSNFSHIKHDSHCPSFSDVLFSKKPSRRPIIPKRPDYTDVDAPEIDGGNELSYTCEENLLRQDSRNSRKRISYADEFSSRPEAPSGDDGGASWLDRIHGASSTTGYGDQWTNSRKMSEQERQSITGNYSQHVRAPSTPFFEYKPRQPMIIEWSDDEDHDASEVDNEAKIHAFNDVRLSRENLDIIGFVNASATPCLTKGKHSNKKKTLSSLSEKEREIQAMLCKIKALEKKKQLQGLNKEQIDTCTELKSTLGKRKAKDAESDDQVHTDVHANLEQSTKVCFWNELESNMVKRARMNYRSSLAWLKEGFTNVCRVFFFFFLNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q562</accession>
    <name>A8Q562_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730350.1">
        <property type="nucleotide sequence ID" value="XM_001730298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q562"/>
    <dbReference type="FunCoup" id="A8Q562">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q562"/>
    <dbReference type="GeneID" id="5854655"/>
    <dbReference type="KEGG" id="mgl:MGL_2732"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2732"/>
    <dbReference type="InParanoid" id="A8Q562"/>
    <dbReference type="OMA" id="RTKKDNH"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054600">
        <property type="entry name" value="TFA2_E-tether"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22254">
        <property type="entry name" value="TFA2_E-tether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFA2 Winged helix" evidence="2">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIE subunit beta E-tether" evidence="3">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="203" mass="23038" checksum="2690E453D749B0F1" modified="2008-01-15" version="1">MSTTLFQRFKQHPKVRYDEKTDLWSYKPDYEVHSAGDIVSLLRKKYYHPFALTSESSAAGMRVAELRESYPPAREAIEELANEKPVEKRQVLVLRGKRDGSIKHVFWNPIQGDLVKPIDDEFKELWHSLNVPNVVDLATDLENEGLSATKLIETAPKATSHSTTAAQRGKKGKRGTAPRKFKLQNTHLKGVDLSRDFVKPGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5Z3</accession>
    <name>A8Q5Z3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2833</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729847.1">
        <property type="nucleotide sequence ID" value="XM_001729795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5Z3"/>
    <dbReference type="FunCoup" id="A8Q5Z3">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5Z3"/>
    <dbReference type="GeneID" id="5854154"/>
    <dbReference type="KEGG" id="mgl:MGL_2833"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2833"/>
    <dbReference type="InParanoid" id="A8Q5Z3"/>
    <dbReference type="OMA" id="NEMPSIC"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="333"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="464" mass="52043" checksum="153B50ED40E492FB" modified="2008-01-15" version="1">MHRAYHISAKLWSQINRFAAFPPTGVSLRQMVIFGRNANPGTLLLASSFLMEELPVRFAHRVKDLQELPGNLSDMPSIIKVKNWYAQSFDELVSFPQPHLPDSLQRKLLKSTVSDTLEPAPATPNPSLEENALLDDGVSKTHLIANSKRAEHSPMRRRPTLNYGTQTRLDGIDWPADVIEFNNRFTRCLERIKHRHDGVVTTIAQGVLEYKRAKKNSTNQADLQVFLDRFYMSRIGIRMLIGQHIALGRACMAPKKSALNYLSAQATKGALSDVSGSEPEEYVGVICTNTNVGAVAHEAIENSRFVCEEHYGLFRAPPVQLVCPKNLTFMYVPSHLNHMLFELLKNSLRAVVERYGVENEDHFPPIKVIVVEGKEDITIKISDEGGGIPRSEVPQAWTYMYTTARSEDLDPDFHSSDFQAPMAGFGYGLPLARLYARYFGGDLRLISMEGACMCLFMLACATRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q643</accession>
    <name>A8Q643_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729864.1">
        <property type="nucleotide sequence ID" value="XM_001729812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q643"/>
    <dbReference type="STRING" id="425265.A8Q643"/>
    <dbReference type="GeneID" id="5854171"/>
    <dbReference type="KEGG" id="mgl:MGL_2850"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2850"/>
    <dbReference type="InParanoid" id="A8Q643"/>
    <dbReference type="OMA" id="NFTHRVH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000348">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="82"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="582"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="381"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="510"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="854" mass="94695" checksum="CFA0914720C13D1C" modified="2008-01-15" version="1">MSHSPINDARWQDMYGLTPSRPAPGPPPVGTRAGSDLYDHSLTNSSSSAISMTPPLTNISPTTSQSSGLTTAPGSTPKSSASVVRKGYVSVKEDGLRSWIWSKKWLVLRESTLLFHKNESTVQATNIVLLRDVRNISRTDLKPYCIEIETKDKTFFLQVKSDEELYGWMDDIYNRSPLGASSPTNFVHQVHVGFDPVSGSFTGLPDQWMRLLTQSAITKEDYAKNPQAVLDVLEFYTDIHNKRSRDDFGLGSPTMNLHAGSSGRQAVDMFKRAEPVISSSQLPPVDSRRATPLPPRGKPKQSPLPAVPREDNMATPSPTGDLSLSLSESDTSALSFRTQQMRLSEEQQRQHIEREEPREYLRRQQQQQQQLLEQQKYAALTERRKLSQPRTLQPPYLPYESPAAVPTSNIPSMAPTTSSTSSTPNSRPNSKPTRFMPTQTQDMPSLPTTNLGMVAPPLTSADMYQAHESPGTTSSSLPSPAQVHSRSQPQVQPQPAHSHSPSPSPSQAQTRPMPSTSPMQGTTTSNAPTHHPPSNTGSGATTAPTVPQRRPEGQKRSSAMSDAQIMEKLRAVVSRNDPNTMYRKVKKIGQGASGSVYVAKALATSQLVAIKAMDLAHQPRKELIINEILVMKESQHPNIVNFLDAYLLRDHDLWVVMEFMEGGALTDVIDNNTLDETQIAAICLETCKGLEHLHRHSIIHRDIKSDNILLNNYGQVKITDFGFCAKLTDQRSKRATMVGTPYWMAPEVVKQKEYGAKVDIWSLGIMAIEMIENEPPYLDEEPLKALYMIATNGTPTLKKPENLSRELKGFLAVCLCADVKSRATADELLQHEFLHKACPTSELPKLLEFRHHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6A5</accession>
    <name>A8Q6A5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729915.1">
        <property type="nucleotide sequence ID" value="XM_001729863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6A5"/>
    <dbReference type="STRING" id="425265.A8Q6A5"/>
    <dbReference type="GeneID" id="5854222"/>
    <dbReference type="KEGG" id="mgl:MGL_2901"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2901"/>
    <dbReference type="InParanoid" id="A8Q6A5"/>
    <dbReference type="OMA" id="MNGSFQI"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF20">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="5"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="342" mass="36795" checksum="818A5E3843BB1D88" modified="2008-01-15" version="1">MSRTALVVVFGPCSLHDVRAGLEYAQRLREYAEKAKDDLHIVMRVYFEKPRTTVGWKGLINDPNLDGSFQINKGLRLARGFLLEVAKIGLPAGTEFLDAISPQYTADLISWGAIGARTTESQVHRELTSGLSMPVGFKNGTDGSVRIAIDAIRSSSSSHHFLSVTKQGISAIVETAGNDKCHVILRGANSGPNYSSEHITSTRSSLEKAGLPARIMIDCSHGNSEKKHENQLKVSENVSEQLSAGDDNAWSILGVMLESNLVEGRQNVPPEGPNCLTFGQSITDACMGWDMTVQALDKLRAGVQARRAKAPASHHTRINSGVLASTSNQSGFNDAALATLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6A7</accession>
    <name>A8Q6A7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MGL_2903</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729917.1">
        <property type="nucleotide sequence ID" value="XM_001729865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6A7"/>
    <dbReference type="FunCoup" id="A8Q6A7">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6A7"/>
    <dbReference type="GeneID" id="5854224"/>
    <dbReference type="KEGG" id="mgl:MGL_2903"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2903"/>
    <dbReference type="InParanoid" id="A8Q6A7"/>
    <dbReference type="OMA" id="QPIMFRR"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="19">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="20">
        <location>
            <begin position="93"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP42703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="892" mass="95928" checksum="BD5DC10ED7D9D4DB" modified="2008-01-15" version="1">MKSLAAAECGIRAQHIKLPSGATEAEIRDKVRSLNDDPSVDGVLVQLPLGDHIDTDAERRITEEIDPSKDVDGFHTINIGQLSSKACNPKFAPCTPVGVLRLLESVGLHNLAGLFAVVMGRSDIVGNPVTHLLRSRDCTVTQVHRHSKHVQQVLAMADIVVVAIGNPQFVQGSWVKPGAVVIDVGINYVPDATKKSGQRLVGDVDYESAWPVVSAITPVPGGVGPMTVAMLMENVLTAAERRADREAEIPRGVTKLNPIVLQRPVPSDIEIARAQVPKRITSLAREIGILRSELEPYGEAKAKVSLDILERLKGRINGKYVVVAGITPTPLGEGKSTTTIGLAQALGAHLKRPSFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDNHAVMAANNLLAAAIDTRMFHEATQSDAALYDRLTPRQKGVRKFSEVMLKRLRKLQINKTDPDTLTEDERRRFARLDLDPASITWRRVVDTNDRYLRQITIGESPTEKGLTRQTGFDIAVASECMAVLALSRDLVDMRERLGRMVVGSNKQGEPITADDLGVGGALAVLMRDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSILADAMALKLAGREAHEPSERAGFVITEAGFGADIGMEKFCNIKCRESGLVPDAVVLVATVRALKSHGGGPDVSPGKPLSDAYTQENLSLLDAGCGNLVKHIQNAKQFGLKVIVAVNRFASDTPAELDLVVQRSLEAGADAAVPSDHWANGGAGAVPLANAIVEQLDHTESQFQFLYALDQPIVAKIEKIARCMYGADGIDILPEAQAQIDTYTRQGYAHLPICMAKTHLSLSHDPLRKGVPTGFKVPIREVRLAAGARFLYPLCGTMQTMPGLNTRPGYYDIDLDAEGQVIGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6M9</accession>
    <name>A8Q6M9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730026.1">
        <property type="nucleotide sequence ID" value="XM_001729974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6M9"/>
    <dbReference type="STRING" id="425265.A8Q6M9"/>
    <dbReference type="GeneID" id="5854333"/>
    <dbReference type="KEGG" id="mgl:MGL_3012"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3012"/>
    <dbReference type="InParanoid" id="A8Q6M9"/>
    <dbReference type="OMA" id="TAWMWIN"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="122" mass="13597" checksum="B97452A6F0CE469F" modified="2008-01-15" version="1">MRASFRSLALSIAGAVAGVLGLQNLWGFGFFAISVVFVNLVLIAVNTGYRPELFFVLVPSPVLTTSMEKLVPGKAEQLRKPLPSIKRLAYMAQWVVVQGAQENLLSFILWWTLWFGLVHVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6P5</accession>
    <name>A8Q6P5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730039.1">
        <property type="nucleotide sequence ID" value="XM_001729987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6P5"/>
    <dbReference type="FunCoup" id="A8Q6P5">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6P5"/>
    <dbReference type="GeneID" id="5854346"/>
    <dbReference type="KEGG" id="mgl:MGL_3025"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3025"/>
    <dbReference type="InParanoid" id="A8Q6P5"/>
    <dbReference type="OMA" id="HEANQVM"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="187" mass="20845" checksum="A88AFDBDCB9E1D92" modified="2008-01-15" version="1">MGAGHSRDLQVVLEREHEVAKIAIREGKKERARLALRQRAYQNGLISKTDQQLATLQELVSNIEFAQLEQSIIYGLTQGNQVLKQIHRETSLERVEHLMEETAESQTYQREIDQMLSSTLSADEQQAVEDELEQLVFQAQQEKIALSGSQPAAKLPSVPTNIPTPASSDSTTVVNTSPERQAILEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6R3</accession>
    <name>A8Q6R3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730051.1">
        <property type="nucleotide sequence ID" value="XM_001729999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6R3"/>
    <dbReference type="STRING" id="425265.A8Q6R3"/>
    <dbReference type="GeneID" id="5854358"/>
    <dbReference type="KEGG" id="mgl:MGL_3037"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3037"/>
    <dbReference type="InParanoid" id="A8Q6R3"/>
    <dbReference type="OMA" id="RFHEIVP"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="1">
        <location>
            <begin position="134"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="242" mass="27496" checksum="64F415A9069508CE" modified="2008-01-15" version="1">MRNGGNMSENQNNSIQVQHRLHSYDILIHETMTVAELQEQICRATGVLPKHQKLLTPPKARQLGQILRSGNTNQQLLPDVGLSADMRLTLVGAPVHEVEREQMQEASLDKSYGPRRLHPSLLKNMQPTKSLPDAQVTAAFGRCRPHSSTQDADPWHKNVRQYLERLASDPAVLHVCKLHHYKVGELCELLPHENPELLGLNVNKGQRILLRVRTDAADGLRDYKTTRRVLLHELCHNEVRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7S0</accession>
    <name>A8Q7S0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729556.1">
        <property type="nucleotide sequence ID" value="XM_001729504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7S0"/>
    <dbReference type="STRING" id="425265.A8Q7S0"/>
    <dbReference type="GeneID" id="5853862"/>
    <dbReference type="KEGG" id="mgl:MGL_3100"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3100"/>
    <dbReference type="InParanoid" id="A8Q7S0"/>
    <dbReference type="OMA" id="YSERITY"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="211" mass="24968" checksum="6B5AF965EC6CF1FA" modified="2008-01-15" version="1">MPAESSAVGPRGRLLADHQFTPSPTNTSFRDLLIFEERLKQNAERMKKRKHKYQMDFMQTRFVLQTSAYTCANGVKVADHVRFVPQANRSLRTFNMHLNMPHTSNAFSWIPVWRKSYFAQRESHANTEEQRMPRSSTRMFSRRPFAPQIPPCQNQRGEIIFSSRVDPDFREGYERYRNAFERKRREKMEAQQRSQPGLWPFWRSSSSSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7W7</accession>
    <name>A8Q7W7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729601.1">
        <property type="nucleotide sequence ID" value="XM_001729549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7W7"/>
    <dbReference type="STRING" id="425265.A8Q7W7"/>
    <dbReference type="GeneID" id="5853907"/>
    <dbReference type="KEGG" id="mgl:MGL_3145"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3145"/>
    <dbReference type="InParanoid" id="A8Q7W7"/>
    <dbReference type="OMA" id="VFPITWW"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725167" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="34606" checksum="CFC6E7AD91E3DD7A" modified="2008-01-15" version="1">MKTFLVALVLGVGIATAFLDPEVLEANVKNSSAHTLRKRSAFSGTATWYDVETYQAGACGYDIDNSMHIVALNEPMYGDLDSRSKWCGKHIMIANGLKTVRAVIMDACPETSQCHHGSLDMSMSLFQEFNDLTLGVFPITWWTIDDSHNDDGDKGRGNGGGKSNSGSASSDSRSQSHSYSRSHSHSQTHSHSRSYSSSTPTSSSYHEHNASRSSAQAEAAASASSARARASSIAREQSLSKASAASSRSSASEASLRSKSSESASHDSSSTRVATSSSDSHSSSTTASSSSSQTTGSSSQDDPRVGNLENFVKVLNGLSMLVHAAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q831</accession>
    <name>A8Q831_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729647.1">
        <property type="nucleotide sequence ID" value="XM_001729595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q831"/>
    <dbReference type="STRING" id="425265.A8Q831"/>
    <dbReference type="GeneID" id="5853953"/>
    <dbReference type="KEGG" id="mgl:MGL_3191"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3191"/>
    <dbReference type="InParanoid" id="A8Q831"/>
    <dbReference type="OMA" id="NIVHMFI"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="356" mass="39577" checksum="17E744532ACEE7FF" modified="2008-01-15" version="1">MRIDSVGIRKRPKLDSDSDDVANGHDDYQNHAKDALAQIEQGLLCGICIELYDRPCVLSPCGHVFCASCLVSWFSVAQEVNEDPYEERRTGLVRRKKVCPSCRAQIVSPPLELWALKDVLAAIHNYRGTAPSTNEIQQSLWDGLFDPTTFYHVIRDQDDGVLRCGMCSSEILEGQCTNRECGIIYENLSEEERAWHASENVHDDSDMISDDDNDDEDAGSLDDFVVDDDVDEGDDVNVSTNESEHTDEESRSVSSDSSVSVIDNSSARNQPSRPVSISSDGDTSSEHSDESNSRNDESSADDECTEVPLNASFVRRKRLEALMKSRARRRDASRSLDLVDQDSRSADATDHDDVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q987</accession>
    <name>A8Q987_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729399.1">
        <property type="nucleotide sequence ID" value="XM_001729347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q987"/>
    <dbReference type="STRING" id="425265.A8Q987"/>
    <dbReference type="GeneID" id="5853706"/>
    <dbReference type="KEGG" id="mgl:MGL_3434"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3434"/>
    <dbReference type="InParanoid" id="A8Q987"/>
    <dbReference type="OMA" id="SLSEWML"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF21">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="288"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="557" mass="62023" checksum="6A96EDC8AAC10323" modified="2008-01-15" version="1">MSALELLTYSSHPLGLRPLGNAYLEGAKDFRTQSLGMLACFEDAFLLQFLVEWMDVQSLLCLSATSRSFYALVNAPLVWREKFIRDYGGRMSGGWPGSWRGAYAAAACTDHAKVKAFVACHISLAHVYSDAVFHDFVTASFDPRPFIEHHTSREIRKLLRKRKMATAATDDVPERPRIPDHIDRVDARAFDTLKFVTRFAHASWPCILTHATDDWPCHAWNLDYIRDVWADRLFQAEALQVNGRTYVEYAHSAGGGGMPVADLGVVPDTSPFYLFDADVAAGEDDAARGWRVPSLIARYPIGAKGEGDAREADERTRADLFSLLGEIRPDYRWLIAGPARSGSCWHKDPNLTSAWNAVTQGSKYWMLLPPKTVPPGVYVTEDESEVTAPASLSEWMLDFYAETKAKHGRRECGGDGQLIEGVCHAGEVMYIPSGWWHLVINLDDSVALTQNFVSVTELPSVLSFMKYTPEQISGFRAGTSKTSVFDQFVERLRAYDAEMTDEALACMPKRKSCRAPTLANEGSDWRVRLSCGVTDESNTTCTLSSLVADEELGDTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9E0</accession>
    <name>A8Q9E0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729429.1">
        <property type="nucleotide sequence ID" value="XM_001729377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9E0"/>
    <dbReference type="STRING" id="425265.A8Q9E0"/>
    <dbReference type="GeneID" id="5853736"/>
    <dbReference type="KEGG" id="mgl:MGL_3464"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3464"/>
    <dbReference type="InParanoid" id="A8Q9E0"/>
    <dbReference type="OMA" id="EVQMQIN"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="164" mass="18961" checksum="2EFA0B5F55AF46C9" modified="2008-01-15" version="1">MGFFSSFTDASKAQDESVDTFEIGRTLLNKLEAAQPDSSAPGPEASRQSVLDENVQKKLSEELAKLRKQEKEVQMQINLALEKENLDREDKPWFGRKDKGQSSHVMQQELDRIKAQVEKYKRRDMSSFPDLQKAREAVVQCYRYVRPHTSMLAHLPHLHAKIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9E8</accession>
    <name>A8Q9E8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3468</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729433.1">
        <property type="nucleotide sequence ID" value="XM_001729381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9E8"/>
    <dbReference type="FunCoup" id="A8Q9E8">
        <property type="interactions" value="689"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9E8"/>
    <dbReference type="GeneID" id="5853740"/>
    <dbReference type="KEGG" id="mgl:MGL_3468"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3468"/>
    <dbReference type="InParanoid" id="A8Q9E8"/>
    <dbReference type="OMA" id="QINETIM"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="82"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="188" mass="21519" checksum="EE45914C5C7782E0" modified="2008-01-15" version="1">MEDDRMEFDHGAYMVWASSTDIKDARIRRRGRGFGANDSSEPDGVKSQGFEQLDVEMDKVDDDDGVKERFNETKAVRSMEGWVLVVTNIHEEALEEDVMDLFMEYGKVQDLHLNLDRRTGFVKGYALIQYKTQQEAENAIDACKRGLTLLEQPLDADYAFVQPPKQPPHARGGSRRPARERSLSPMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9G3</accession>
    <name>A8Q9G3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729441.1">
        <property type="nucleotide sequence ID" value="XM_001729389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9G3"/>
    <dbReference type="STRING" id="425265.A8Q9G3"/>
    <dbReference type="GeneID" id="5853748"/>
    <dbReference type="KEGG" id="mgl:MGL_3476"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3476"/>
    <dbReference type="InParanoid" id="A8Q9G3"/>
    <dbReference type="OMA" id="ARIMRME"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="2">
        <location>
            <begin position="138"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="2">
        <location>
            <begin position="292"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="395" mass="43248" checksum="F9899DF71C662582" modified="2008-01-15" version="1">MHVHPSSRSLPFYCWPAIDLPAVLACPYLHTIGRRAHGQRAHAPPPLVCKWVGGWRFEGTPKERYFYPGPCAQRAYVPTDSHHDSSAIQIETTMSLLSRFSQAFRRSLLGWQSEAARIMRMEVSATENATQSQLFYKINNSADLSQIATGSDSDIGGLSRCHMSLEHDDPGQEKTPASFGRFYGTLSSQIPRGSALERSGYAAFRNKSRPTLFSTETWDTSFHPYLALLVRNRTAAVKGTGPSISPSHSRTHSLRSALHASDPTGPAIPRAIDALGLTHAGMTGHASNLPLFFVNIQTDGPVTTDLYQHRLFLDDSQGNAWQTITIPFDSFVLTNTGVVAEDQISMMREKILTVGISALIEPPLLPDSQDVVEEEPASPATQGPSALRRTSSPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9L3</accession>
    <name>A8Q9L3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cwf19-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729467.1">
        <property type="nucleotide sequence ID" value="XM_001729415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9L3"/>
    <dbReference type="STRING" id="425265.A8Q9L3"/>
    <dbReference type="GeneID" id="5853774"/>
    <dbReference type="KEGG" id="mgl:MGL_3502"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3502"/>
    <dbReference type="InParanoid" id="A8Q9L3"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23324" checksum="8352A69A7A85BD5C" modified="2008-01-15" version="1">MKCLLRMAVSKNQSMVFFETVLSLRMQKHTFIEAVPIPNDVFPQVPAYFYVALSEVESEWSDHKQVIGFSEQRPFQSSMVSRLPYFMIQWDYKGQRGYGHVIESRQDERGRFAPSGRDEPVYDDGDHVGGTGFPAYVYKPFLRTDTLTLPTSLFSNFAHEIIGNMLQLEPQRWRKPKHVAGMRQLVDQFKASWDAFDWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9L5</accession>
    <name>A8Q9L5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729468.1">
        <property type="nucleotide sequence ID" value="XM_001729416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9L5"/>
    <dbReference type="STRING" id="425265.A8Q9L5"/>
    <dbReference type="GeneID" id="5853775"/>
    <dbReference type="KEGG" id="mgl:MGL_3503"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3503"/>
    <dbReference type="InParanoid" id="A8Q9L5"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="193" mass="21817" checksum="8BC9B40F395C36D5" modified="2008-01-15" version="1">MPIASSVSHEHSVLSASELNKLEAQVLRAEFANRPDAQALRRELESARKKIVSIAPSERVEPVPVIDGFGRMYDIGSRSSSEATIQAESLRSSKRPKFESDAPDDVSLSDLVRQERFTAGRADQKDYDMMLSQQIAGDRAFVNDTDYLDDEAQRFARKRMRDDAMKRQFAIQGTCIYRTGLENVVFSQWAYTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA34</accession>
    <name>A8QA34_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729127.1">
        <property type="nucleotide sequence ID" value="XM_001729075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA34"/>
    <dbReference type="FunCoup" id="A8QA34">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA34"/>
    <dbReference type="GeneID" id="5853433"/>
    <dbReference type="KEGG" id="mgl:MGL_3594"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3594"/>
    <dbReference type="InParanoid" id="A8QA34"/>
    <dbReference type="OMA" id="SGIWRQI"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="194"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="482" mass="53054" checksum="CA5EEEF2B6A61779" modified="2008-01-15" version="1">MPSNAVGQDMGANDVMSDAAHTLAPSAIENDVKIDTRVSEHNLIKAMQQLQMSLIDPNDIPILRLSAIRLNGLKNTRHGFLSSLCRPYVDPTAPFTFMADLRYGHRMNFPPLGEPTTVHTILQAATSFSSDISRMDIAKDISVHMEPSRVSQEHPTEDVDLILDIKPASRFFLKTSTSVGNSEGTASIQGKIRNLFGGAESLEGSAMLGTRTKHSYNLVFASPVFACPDLWVNVSAVSQHRDLTSFISAHEGQHMLRSALMYAQNDGTRHELAYEASHRHFHHMMPDASVAIRRLALPSFKSAISYTVERDSRDNTFATMAGTYFRSLWEYAGLGGDTSYMKVETHSSVSDIFADGCSWSLGAKFGMMVPLNGQTPCLNDRFMLGGPTCIRMFRLNSLGPKFKRQLSQLQQSTCDLVLTPPGSFWTMQRLVELAQPSASAGLGLLFQQGPIRLELNFGLPIMARCGDGLRKGLQFGIGIDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA47</accession>
    <name>A8QA47_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729139.1">
        <property type="nucleotide sequence ID" value="XM_001729087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA47"/>
    <dbReference type="FunCoup" id="A8QA47">
        <property type="interactions" value="712"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA47"/>
    <dbReference type="MEROPS" id="T01.987"/>
    <dbReference type="GeneID" id="5853445"/>
    <dbReference type="KEGG" id="mgl:MGL_3606"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3606"/>
    <dbReference type="InParanoid" id="A8QA47"/>
    <dbReference type="OMA" id="QPIMRRY"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="270" mass="30264" checksum="309DDBA71F27EDF8" modified="2008-01-15" version="1">MYAYPGQTWSSRPQADCVSSQTNVFDMHAPERRPVDAFDGARQHTQQPIVTGTSVLGLTYKDGVMLATDTLASYGSLARFMNIQRLAQFGERVVIGASGDMSDWQNIRHSLTKLMEKEEMESDGHTLTPAQMYAYLSRTMYERRSKLDPYWNALVLGGFDTKTNAPFLGYVDLLGTTYQSSTIATGFGLHLAQPMLRKAVEGRETHLTENDARAILEECMRVLFYRDARSLNRFQIAKITADGAHISEPYSVPTHWGFAEGLRGYGPQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA96</accession>
    <name>A8QA96_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729188.1">
        <property type="nucleotide sequence ID" value="XM_001729136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA96"/>
    <dbReference type="STRING" id="425265.A8QA96"/>
    <dbReference type="GeneID" id="5853494"/>
    <dbReference type="KEGG" id="mgl:MGL_3655"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3655"/>
    <dbReference type="InParanoid" id="A8QA96"/>
    <dbReference type="OMA" id="SSKWRQG"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="361"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="395" mass="43738" checksum="28F3B73C44DBEED9" modified="2008-01-15" version="1">MLGRAVHMARAVCSMSTHSLRRHGAKISSVRFIHGPQVPPAEPVSADASIGSQDDTSELYALERSSPLVHTRLTYLSPETRPQGKRAIAYVPMSSHVFNTAPHQHAMHMAVVYYLDALRSGTASTKSRSDVAYSGKKLRPQKGTGRARLSDAGNPMLRGGGVAHGPKPRDFKTDLPRKVRELALRSALSARFREGRLHVVPSLDWYAPPMSTNKLARLLSAKQWTNTLFLTAPRDPVSPVANERGSMRPSSVNLMYTDQQLTRHAQYIRHFALAQRNLPDVDLVRLHELPPHPRPRLEHAKQPGELHAYQVLEFQRIVLDMGALEWLEEKLGGSLVHQVYAEEMLRWREERNPSASDEDAFSPSTSSISESENSASSGLSSTSDTASSMQSPTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA97</accession>
    <name>A8QA97_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMR1-interacting protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729189.1">
        <property type="nucleotide sequence ID" value="XM_001729137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA97"/>
    <dbReference type="STRING" id="425265.A8QA97"/>
    <dbReference type="GeneID" id="5853495"/>
    <dbReference type="KEGG" id="mgl:MGL_3656"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3656"/>
    <dbReference type="InParanoid" id="A8QA97"/>
    <dbReference type="OMA" id="EWINQRK"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMR1-interacting protein 1 conserved" evidence="2">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="623" mass="69403" checksum="BC228E15F7123771" modified="2008-01-15" version="1">MVEHVPSQARRVKKVAQYDDYGNYLGDIREDELMKKMSAHEKEPSASTIESAPLPLPASELQPSLPGFSASSQPTDSSIRAISSQIPRKLPARPRWKPSGPVLYCGVDTTLLSTPSRCTFSTHSELELMLHRADRHLLYPPGGMEELKRRDPMRMAEEREKQVRLRKGGTRAADGPADSTIFGLNIRLDTPELMEEWIRQRRKRFPTSAVIAQKQVKHQARLLRDKRSAQTKDFACATSTGTEPHKTPARDTSASQTHDSKQSFDLNRDMELKEGPNGHGKETPAASTEDSSSSEKESDSSSASGGKGSESGDSDSNSDMDSEADAISSKIEPRARPDDEVRSETRQGQKHAVSENTQPVRRVRPRNTASNPFQVPDLLRQLLEREILQHVDALSQCIQFILDNDMLTHVERSPGEAQQQRKQRSRVVVVGEQTEEIGEMRDTNETARPALPRVASPALRALDELEWPDEPDPLIYLDPLRAADPKPLRHEELMSLATDTQLRAILQPISALHPYGEEHRPLRRALESWAALPTPRHREAALQLILGVGADSPMHAHEAYAPAYQRARVTSRGTPMRQNRPIGETELFRLGLRVGPGEVRLIQHIAERVSVVTAGLEYAATAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAC7</accession>
    <name>A8QAC7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="15">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_3686</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="15"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729219.1">
        <property type="nucleotide sequence ID" value="XM_001729167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAC7"/>
    <dbReference type="STRING" id="425265.A8QAC7"/>
    <dbReference type="GeneID" id="5853525"/>
    <dbReference type="KEGG" id="mgl:MGL_3686"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3686"/>
    <dbReference type="InParanoid" id="A8QAC7"/>
    <dbReference type="OMA" id="KGPEMQK"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000069">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="4 14 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="72"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP42005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="324" mass="35548" checksum="FDCD64F6C157ADB2" modified="2008-01-15" version="1">MKSAARPAQYMRQFSSGKTNANAPSSNLGLYLSAGGVAGLGAWYAMGGFNGDIRSKIQQVNADSGDVALSGDEFRALKLKEVRPYNHDSSFYVFELPDNKRSGIFTASALVIRGAGEEPKDKDGKPVIRPYTPVNPPTDKGELVLLIKHYPQGQMTQYLKSLKAGDEMHFKGPIPKHPYKANQFEEIGMVAGGSGITPMWQLIQEISSNPADKTKVTLLYGNKTEADILLREKFDEISKDDRFKIVYFLDEASKNMKAEKGFITKEHIQKYLPGADKGEKAKIFVCGPPPMLKAVAGPKKGFQQGELSGALADLGFKSEQVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAJ9</accession>
    <name>A8QAJ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729291.1">
        <property type="nucleotide sequence ID" value="XM_001729239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAJ9"/>
    <dbReference type="STRING" id="425265.A8QAJ9"/>
    <dbReference type="GeneID" id="5853597"/>
    <dbReference type="KEGG" id="mgl:MGL_3758"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3758"/>
    <dbReference type="InParanoid" id="A8QAJ9"/>
    <dbReference type="OMA" id="QTFKKMD"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="127" mass="14487" checksum="674EE9C3E1AC523A" modified="2008-01-15" version="1">MDEDDREFSQSLVWNYFEQAESTFQKMDGALYVDKDGGTYNYRIAKSLEELSTLGHFLKGSSAAVGVIKVRDSCEAIQHYGKCHEPDGVTQLDPDTALLRLKDTLHNVKEQYEEARSTLRAFFRVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAP1</accession>
    <name>A8QAP1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729012.1">
        <property type="nucleotide sequence ID" value="XM_001728960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAP1"/>
    <dbReference type="GeneID" id="5853319"/>
    <dbReference type="KEGG" id="mgl:MGL_3800"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3800"/>
    <dbReference type="InParanoid" id="A8QAP1"/>
    <dbReference type="OrthoDB" id="17066at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="116" mass="12604" checksum="8C0B3D4BDC9E2AD9" modified="2008-01-15" version="1">MAAGGREKQIMCEPMWGTWSMSRFVRAMSSLSSQYMLSTVHVSTLLPQLCAPPRSEPSNASSKPRSALTMLIKLPCLHTSGVTANAPSFGSDADALAGASRHFFEHICETEVRSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB93</accession>
    <name>A8QB93_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728898.1">
        <property type="nucleotide sequence ID" value="XM_001728846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB93"/>
    <dbReference type="FunCoup" id="A8QB93">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QB93"/>
    <dbReference type="GeneID" id="5853203"/>
    <dbReference type="KEGG" id="mgl:MGL_3892"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3892"/>
    <dbReference type="InParanoid" id="A8QB93"/>
    <dbReference type="OMA" id="WQMQSSV"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="160"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="855"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1092" mass="122104" checksum="D71B5A9EB638CCB2" modified="2008-01-15" version="1">MVDYAPSVQNAMHSDKGVSAAAPHRRSTSSQRHASMRRTGTSPATPNTTVTPTTSNSVPNATEAAELNAAGIMLGPGVRMEEERERHVRKDQVCVKCSEVITGQFVRALSGVYHLDCFTCADCGRNVASKFFSATEEMVKAAGGEQFPLCETDYFRRLDLLCAKCGRALRGSYITALGSKYHVDHFTCSLCSTPFGPEDSYYEHEGQVYCHFHYSTLFAIQCTGCQTAILKQFVEINRNNADEHWHPECYMIHRYWKIKLAPAGPAPSDTLPDEVPLSMPGGLTLTPSSSEEQLVQTRRTHEETPTSVLQKQRAMEIRVFTIWRVLSSFEESSAGCISDMLRHVSNGKYVGGVRFAARFVLHVEVLFSAIDELAVYFQKAHASTIQYVREARMLCKKIVNFFSLLSHTQEMGVQRMHITQELLSLVTGLAHYLKILIRISLTGALRLDQEHGVPTALESFLARLDELVTLQGGDTDTVHGYTSLPQVCIPTYDTESASDLCVTCGKTVEDECLRVGITMRWHWSCIRCTNCQRVVVKPDGTIPVRQDNEDIEPTPAPGAITHFVVHSMGRHDRPSTFCTTCMPSDANGHFLPVTRLEQYAFLLCVALNRLDALLKRRARLQVPSSANTSSSDEPDVGELTDAESSTYRKSPETKRLENQYLNRHMSNKARVPRISTVVNEPTVTDDSGTSAAAAEVAGTATTVLASADPSPLTRERAIVPTHEEVVVRERDRIRERSRERERTPIPSRTDIDLTHDEGITLADIPMILQAEQDREQREQLGVHVRRPISSLSAEEMQVSKCVAILRLQKSALAELVDTDELLDLVETRKNTFWGKILFRGSSRRSDVRKKGVFGVSLDYLVDRHGADSVLGATPTPMRVPAFVDDVVSAMRQMDVSVEGIFRKNGSVRRLKELSDALDREVEAINMLDDHPVQLAALLKKFLRELPEPLLTSRLYRLFLQTQTIDSAKERHRLVGLIAMLLPRAHRDTLEVLFVFLRWVATFAYVDDEAGSRMDLHNLATVMAPSLLYSRNSEPSHGEAILAQAVVCHMLEYQDDLWFVQHDMDAALRDRSLIAAVPELTPHELLKRCALYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCD6</accession>
    <name>A8QCD6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="6">dUTPase</shortName>
            <ecNumber evidence="6">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728830.1">
        <property type="nucleotide sequence ID" value="XM_001728778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCD6"/>
    <dbReference type="FunCoup" id="A8QCD6">
        <property type="interactions" value="841"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCD6"/>
    <dbReference type="GeneID" id="5853136"/>
    <dbReference type="KEGG" id="mgl:MGL_3997"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3997"/>
    <dbReference type="InParanoid" id="A8QCD6"/>
    <dbReference type="OMA" id="GREFHTQ"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="8">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="152" mass="16088" checksum="9B7A395C23F434AE" modified="2008-01-15" version="1">MAMRLLVKRNPAYPLAKLPTRGSAQAAGYDLYACEDATIPRGGRTVVQTGIHIALPEGHYGRVAPRSGLAVKHGIDVGAGVVDSDYRGLLGIVLFNFGTEDFQFHAGDRIAQLVIEKISNPEVEEVESLEATERGSGGFGSTGGFSSSTRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCH1</accession>
    <name>A8QCH1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_4008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728841.1">
        <property type="nucleotide sequence ID" value="XM_001728789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCH1"/>
    <dbReference type="GeneID" id="5853147"/>
    <dbReference type="KEGG" id="mgl:MGL_4008"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4008"/>
    <dbReference type="InParanoid" id="A8QCH1"/>
    <dbReference type="OMA" id="SEKWIIP"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="61220" checksum="28CAE3CA7D933A21" modified="2008-01-15" version="1">MIKYLFKILEGIILYLYEFIQLFISVFFSPLPPTKDSPRIGHVAVIGAGITGISTAAHLRSHGFEVTIFDESPDIGGIWRRVNSTSNLQINSLFYRFHPLAFYRSFYPFRDEILAQQHKVLTTYGLDKCIRFNTRVTKIERHSSSSSQDSKIGGPSRWIVNGNKSEVFDGLVVTIGTCGKPRIISLPNQDQFKGKIIHSCELDDLDYTGKSVVVIGGAASGVEVAETVVAKGAKKATILARSDKWFIPRNVILDSCLSMFPYIFKTLTTLVPEQLIRRLHYRDLEEKMTPTFPLYSSTPVVNNAFFRLVRQGSADYHRGEVTSVKSDGLEWNYRLRSQRKGEEGEKKFINADIIVLASGYHRPSMDFLPKDLFPDGYSGPNMYLQCFPVHDPSIVCTNATYVDGFGSVGSLHIGIYARLLALFLRRPETRPSSQFMRFWVDTVRIFKRGFFGGPLEFFTYPEVCIWLAVCMLQCPERIPYFFFVMFGFGEWYVAKDGSSRFRYPIMNFWSRIMKQLHRLPLERPQFYIPGPQQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCW0</accession>
    <name>A8QCW0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hypothetical aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_4053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728886.1">
        <property type="nucleotide sequence ID" value="XM_001728834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCW0"/>
    <dbReference type="GeneID" id="5853192"/>
    <dbReference type="KEGG" id="mgl:MGL_4053"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4053"/>
    <dbReference type="InParanoid" id="A8QCW0"/>
    <dbReference type="OMA" id="FMQYMRA"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728081" evidence="3">
        <location>
            <begin position="21"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="98"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="394" mass="43220" checksum="5BF501E19C92AC07" modified="2008-01-15" version="1">MLLLPKLFAGVAAIASLVAAQKHEGISIPMSRRGISKGETNFHELAAGIKKVFNKYEFGMNNFKLKMGKDHPLLGSKLEKRDSTSSIKMFDIAGETQWIGEISIGTPPQRMLVQFDTGSANVIIAPDAYKPSQSNSSFKAKDQFKTGYGDGTKVEGNVYVDNFELGGIKARNLSFGLTNENFLQDFERESSGIGGLSFPSISNFDSKYLTLIEALMQQKSLKQNVFQFTLKPGEGSTLIFGDIDHSKFNGDLTWVKVNPLFGFYIADAKINGKKIRTAVDSGTTVIIGSRSQVKDLVERTNGVHYAEDRSTNIGYGLFDCDFSPEVIITYGGTDFKLNRDQVSRGTANGKCLLSVIGIDSILPFDTWIMGDPFFQAASIVFDHDNNRLGFASQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD59</accession>
    <name>A8QD59_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Manganese/iron superoxide dismutase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728792.1">
        <property type="nucleotide sequence ID" value="XM_001728740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD59"/>
    <dbReference type="FunCoup" id="A8QD59">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD59"/>
    <dbReference type="GeneID" id="5853098"/>
    <dbReference type="KEGG" id="mgl:MGL_4127"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4127"/>
    <dbReference type="InParanoid" id="A8QD59"/>
    <dbReference type="OMA" id="YLKRFWT"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF3">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [FE] 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="107"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="280" mass="30719" checksum="A5BF289C79F0EAA7" modified="2008-01-15" version="1">MPAALTEGCDPFLSKRTVHLLWTQWQAGLLQRLNEEVKGTPNATESVVETVMNTARDREKILMFNYASLALNTSFFLSSLVPHAAQSVQAYPQPSTHMGAVPTFYGKTLATAIADQFGSLPQLKLAVSSAAMGMVSSGWIWLVKDDHGRLGIVPTYGASTVLVHQRRQCGPSDLVTTVQDGQTSSDAATPATTPASNESTSATTPAQELRASAPNRFDSLSRSSAAGAIGHHLYPLFCISMFEHAWLGDYGFWGKERYLTHFWDCLHWERVERLWGDDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2023-06-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDF6</accession>
    <name>A8QDF6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_4200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728721.1">
        <property type="nucleotide sequence ID" value="XM_001728669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDF6"/>
    <dbReference type="GeneID" id="5853006"/>
    <dbReference type="KEGG" id="mgl:MGL_4200"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4200"/>
    <dbReference type="InParanoid" id="A8QDF6"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="182" mass="19955" checksum="E484C7BF19A1E1F3" modified="2008-01-15" version="1">MMAAMMAMSMASPVTQRDIGGQEAEEACKPVYRGTLVLHDGENTYGVKEEGVMYGAKFVKKQDEVNNDLKYKFLDCKKGKKGSEKRYGVLELDHSPDECVLGSTVDGSKKAPALVVGMCGYNGDHEFAATREGKDVKLTYVLEDGTEHDGWESKNATGMLVKSIRMVKGNGKWMGLSDVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDU8</accession>
    <name>A8QDU8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000023">
        <property type="protein sequence ID" value="EDP41425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728639.1">
        <property type="nucleotide sequence ID" value="XM_001728587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDU8"/>
    <dbReference type="FunCoup" id="A8QDU8">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDU8"/>
    <dbReference type="GeneID" id="5852932"/>
    <dbReference type="KEGG" id="mgl:MGL_4238"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4238"/>
    <dbReference type="InParanoid" id="A8QDU8"/>
    <dbReference type="OMA" id="WIEYHEQ"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="260" mass="27611" checksum="87F058715B3B67DF" modified="2008-01-15" version="1" fragment="single">MPGMEAMIVDGKSAASVKHVEAPKLRPRSILVRVHCNALNPTDWKHLDYFGKEGATLGFDFMGTVIEKAPDAGTSVKVGDRVAGFLHGGWDAGVGAFAQYVATMPEYVVAVPDSMSDEEASGLCVAGITALFGLFQNKQLGLPEPSGTELPPVDPKLKVLVWSGASSVGQFVIQMARAIGAYVIVTASAKHLDWLKSLGASELYEYSNSETPKRIAEAHPDLKYAFDTYSMNGSQAACAASMSKTEAGKIVSLLPFDHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDX9</accession>
    <name>A8QDX9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_4243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000024">
        <property type="protein sequence ID" value="EDP41404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728618.1">
        <property type="nucleotide sequence ID" value="XM_001728566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDX9"/>
    <dbReference type="GeneID" id="5852928"/>
    <dbReference type="KEGG" id="mgl:MGL_4243"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4243"/>
    <dbReference type="InParanoid" id="A8QDX9"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727327" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="65"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="388" mass="42584" checksum="7944F8F2152E159B" modified="2008-01-15" version="1">MFLNLVALALIQAVVIASARLTFQLERSSQPPATHIDSLVKDELDVLSAKYIHNAFAFRKNTGLHDSSVNATTLRKRSAAQIQMNEEADHSDPWSTFISVGFPPQSVAVTFDTSSADVTVDSSYDAEKSITSRQLSDPDSVHVDDISFGPFELKKVAISPSSYNSARIGLAFPSISSAPPVNSFTNVLSLHLEKNIYQFTLGEKHGSLNVGSFDHSMFFGNVSWNAVNPAQGYWTTPFTWNGLSFRGTVDSTSRVVLGSNADVKRLLMSMEGVRITKSKDGSYIGLFDCDKATSSDLVLGGVPLKFSASVKHNNECQVPIIGMDGLNHWILGEPIFQLVSVILDFDNHRIGFARRRVNTQRSTRPRSVNTFRSRREGKSPNIHAPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8QED3</accession>
    <name>A8QED3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_4265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000032">
        <property type="protein sequence ID" value="EDP41386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728600.1">
        <property type="nucleotide sequence ID" value="XM_001728548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QED3"/>
    <dbReference type="FunCoup" id="A8QED3">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QED3"/>
    <dbReference type="GeneID" id="5852906"/>
    <dbReference type="KEGG" id="mgl:MGL_4265"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4265"/>
    <dbReference type="InParanoid" id="A8QED3"/>
    <dbReference type="OMA" id="NENGAMQ"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="10">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="345" mass="38468" checksum="98B0FCCFE2D2390A" modified="2008-01-15" version="1">MFSEYCSEPYVIEPIRVIYPDGREVITPNLDPRKTTLHVSYVNRCTGLKQTGEEIAGLLKRMGHGACPSASDPDIVDVLIPVTRPDILHECDLMEDAAVAHGFDNLPKTFPQTNTVGGPLPINKLGDVIRHQCAQSGWLEVLPLILCSHDENFGWMNRSDDGKTAIVLENPKTSEYQIVRTSLLPGILKTIRENKNHALPVQVFEVSDVAFKDASEKQRMARNERHVAAIYCNKAAGFEIVHGLLDKLMMMLDVPRIFNGDEKAQRGYYLREAEDPSFFPGRAAHIVLRQPVPSSRGLESTHDLMQALGGDQCVGTIGVLHPEVLHRFDLAFPCSAFEFNLEPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQY4</accession>
    <name>A8PQY4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732765.1">
        <property type="nucleotide sequence ID" value="XM_001732713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQY4"/>
    <dbReference type="STRING" id="425265.A8PQY4"/>
    <dbReference type="GeneID" id="5857071"/>
    <dbReference type="KEGG" id="mgl:MGL_0540"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0540"/>
    <dbReference type="InParanoid" id="A8PQY4"/>
    <dbReference type="OMA" id="PREWSIA"/>
    <dbReference type="OrthoDB" id="3357304at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="240" mass="27313" checksum="824700198D4C4C6C" modified="2008-01-15" version="1">MLALVFHQCFTAGYHYPLNRLNFVLQILSSILLVIYQAVTLGVNLSELSQFSKNWPFMFPYIAYRLPRRDTWTLAQVVFFIILESLMALLAHANYIQFLMLIFPSKLERSLIFWMLGPMALVQAGMFFADFAKFNDFKTIDLADALVNICDASLALLYTSGLLIWGGFVNWRRAWRTDGSTAAFGIAVLVVAVCKTVVSFVHIAYDRAYWIRLLSATFTNWQCWLGVLVVGVGGHGDWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQZ9</accession>
    <name>A8PQZ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="15">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_0555</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="15"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732780.1">
        <property type="nucleotide sequence ID" value="XM_001732728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQZ9"/>
    <dbReference type="FunCoup" id="A8PQZ9">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQZ9"/>
    <dbReference type="GeneID" id="5857086"/>
    <dbReference type="KEGG" id="mgl:MGL_0555"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0555"/>
    <dbReference type="InParanoid" id="A8PQZ9"/>
    <dbReference type="OMA" id="LDMKGPF"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP45566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="235" mass="26509" checksum="72975270980D16E5" modified="2008-01-15" version="1">MPKRPSPAILTQRRYRFEIPHKFGLPVGQHVSMRAMIRGKYVMRSYTPISDNDATGYVDFLVKTYEAGNLSRVFNNLKIGDTMQMKGPKGRFKYLPNMTERIGMVAGGTGITPCLQILRSALADPTDKTEFKLIYANVSEDEILMRKELESLQRKNPLRFSVYYFLNVAPPNWQGGVGFVTKEAMADFLPAASSDCRILMCGPPPMMNVMKKHLVELNYPATGDISHGDDKVFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRU9</accession>
    <name>A8PRU9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732358.1">
        <property type="nucleotide sequence ID" value="XM_001732306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRU9"/>
    <dbReference type="GeneID" id="5856664"/>
    <dbReference type="KEGG" id="mgl:MGL_0133"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0133"/>
    <dbReference type="InParanoid" id="A8PRU9"/>
    <dbReference type="OMA" id="MAVWAYS"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="225" mass="21658" checksum="21F3F1A9C0FD3175" modified="2008-01-15" version="1">MDQQEQVSDDVSALEKRKGGSGGGGGGHAAGGGGAARAGSAGSGGSKPRPAGHDSAPKEPDGGKEGGSPPPAPPPPARPPPGNQGSNAGSRNNGGPNNGSGNKGIGFGAGAGAGAGAVAGAGAARHRHNHHDTSSSCSQVTSTCEGASCSSVSDSCAQSTSSSQTPTKTSARQAAPTSESKPTSSDSSQASSPPQTSQPSSASKRMAVWAYSFGVIFSIISYFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS69</accession>
    <name>A8PS69_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732429.1">
        <property type="nucleotide sequence ID" value="XM_001732377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS69"/>
    <dbReference type="FunCoup" id="A8PS69">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS69"/>
    <dbReference type="GeneID" id="5856735"/>
    <dbReference type="KEGG" id="mgl:MGL_0204"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0204"/>
    <dbReference type="InParanoid" id="A8PS69"/>
    <dbReference type="OMA" id="FVFICPM"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="161"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="319" mass="37204" checksum="D4BFAFD4443664AA" modified="2008-01-15" version="1">MDLVLHLADEFLLDNVWAKMLPASRYSPICSATHAMALNQTITEADRLMACGAPGQEVSWLPRDNIIRQIISLYVITYIGIILLYFSCAGFSYYFLFNKDLKKHPLYLKNQVKLEIQSSLRAFPMLDLLTLPWFVLEVRGYSLAYDRWDEYGLWYLILSVPLFLVFTDACIYWVHRSEHHPRIYKYIHKPHHKWVVPTPFASHAFHPLDGYAQSLPYHIFPWIFPLNKLLFLALFGFVNIWSIMIHDSDMINNTGLEKYINGPAHHTLHHLYFTCNYGQYFTTCDRLCGSFREPQAEDDPLLEANGVPRPQRAKPTKSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSC0</accession>
    <name>MDM12_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MDM12</name>
        <name type="ORF">MGL_0230</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732455.1">
        <property type="nucleotide sequence ID" value="XM_001732403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSC0"/>
    <dbReference type="SMR" id="A8PSC0"/>
    <dbReference type="FunCoup" id="A8PSC0">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSC0"/>
    <dbReference type="GeneID" id="5856761"/>
    <dbReference type="KEGG" id="mgl:MGL_0230"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0230"/>
    <dbReference type="InParanoid" id="A8PSC0"/>
    <dbReference type="OMA" id="IYWERIT"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000384293" description="Mitochondrial distribution and morphology protein 12">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="298" mass="33442" checksum="C8B164A4A635C24C" modified="2008-01-15" version="1">MSIELDWTGLEKSFADSLCERLNAALADMDMPTFLGPTRVQAIELGSEGPDVQVIHIGHVWREFREAAVHASSASDKYNARATTPPRMPMRLRTFRQYDDNDLPTSVHGGADADSIASEHEESLSRWSDTESETGTCDSSSLWEEQTRLSDIPSLQMHLSVQWLTSTMRLSLTTSLKIAYNNDTIMSLPISLVVTGMELFAQAIVALDGVHRCVYLSLSEDSTEECAPDGLRAVHDARIRTRHQGQRILPFLALESKVGESAKHVLENVGKVERFVGDMLRQWLEDELVYPHFYTLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSG2</accession>
    <name>A8PSG2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732477.1">
        <property type="nucleotide sequence ID" value="XM_001732425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSG2"/>
    <dbReference type="STRING" id="425265.A8PSG2"/>
    <dbReference type="GeneID" id="5856783"/>
    <dbReference type="KEGG" id="mgl:MGL_0252"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0252"/>
    <dbReference type="InParanoid" id="A8PSG2"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="58" mass="6605" checksum="A8D24122DE70414E" modified="2008-01-15" version="1">MDQDYWGVDDILAESQHIPCVFHVDVPGLGYLEGSGDDDIHKHSRLELPYWIAHMLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTE6</accession>
    <name>A8PTE6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Golgi to ER traffic protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732637.1">
        <property type="nucleotide sequence ID" value="XM_001732585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTE6"/>
    <dbReference type="STRING" id="425265.A8PTE6"/>
    <dbReference type="GeneID" id="5856943"/>
    <dbReference type="KEGG" id="mgl:MGL_0412"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0412"/>
    <dbReference type="InParanoid" id="A8PTE6"/>
    <dbReference type="OMA" id="NGMKYLQ"/>
    <dbReference type="OrthoDB" id="5393181at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38270" checksum="8019017F696397F4" modified="2008-01-15" version="1">MSDDAAAKREARKRRILEKSGDRLSRITNTGRGKDYEGLDTKPIPGMPSRGISDTADALTGPTPSAALKNEEPPAHDASDPFTSMMAAMQSRMGAQEQGSGASRGADGSNDSNMPSDPMALMQQLLSGSGMQQPGAMNNGAGDASNPHTMMQVKEARRIERSVRRVKLLQATLVFLFAFYIVFSSIFSHAHDTGLTGRSIPTESMSEFSRESFQKQWASLAWEYTPISAWLSKDDPSVFPWGALRTPLDSLRPYIGHETLGKELPSWPIFWVFVSMEMGLQGVRLAMLQRMPVSLPGGLKSVISVYAPGIQRLLTPALTLLSLASSLVDDLCILLFAIGTGVLFCHVRTDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUN3</accession>
    <name>A8PUN3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732133.1">
        <property type="nucleotide sequence ID" value="XM_001732081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUN3"/>
    <dbReference type="GeneID" id="5856439"/>
    <dbReference type="KEGG" id="mgl:MGL_0726"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0726"/>
    <dbReference type="InParanoid" id="A8PUN3"/>
    <dbReference type="OMA" id="RFAACIC"/>
    <dbReference type="OrthoDB" id="3334163at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="364" mass="41106" checksum="3D8BBD0193CD6859" modified="2008-01-15" version="1">MSFTLPPPLKQQLTLYRDSLNSQIEAWAAEYHVNPAAIRRHLGFSREFGRQPNSWNLYQRYLAEQKRKNANGDPSALDVGSGTGRTDAGASQAQRIRDELAPLYQKMKEDPEFMLRTRQEISAWEQDNRLEKSSTITRAEYKRAVRRFEQFSQQCSQNLGAESFTIIAHPNIGSNHVQITASPAGLHAFQTALGAGKPLETFQNRFAACICLTIAPTDDPTALERETNLDVQVPLQPQEPIILPEDPTLLTSIQKRKLATPLFQRLVESGLDPVGLANFRKKSQSRFPWKGLMTWLYENGYRFNYWPNDSTLYGVRHAAGEAALLPAHLRCEGLNTPNCWKSDAMNAILRACVDPTDPLRVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUR8</accession>
    <name>A8PUR8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732163.1">
        <property type="nucleotide sequence ID" value="XM_001732111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUR8"/>
    <dbReference type="STRING" id="425265.A8PUR8"/>
    <dbReference type="GeneID" id="5856469"/>
    <dbReference type="KEGG" id="mgl:MGL_0756"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0756"/>
    <dbReference type="InParanoid" id="A8PUR8"/>
    <dbReference type="OMA" id="TDKVAKC"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="153" mass="17715" checksum="83A8FD274279078A" modified="2008-01-15" version="1">MHYGPLYKHIHKIHHEYVAPFGLAAEYAHPLEVLILGLGTIGGPFLLCAYTKDLHILTVYIWIVLRLFQAVDAHSGYDFPISLHNWIPFWAGADHHDYHHMAFLGCYSTSFRWWDHFLGTDRGYQRVRAKQNAAKLRAKADELDQVAAKYKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVB8</accession>
    <name>A8PVB8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vesicle transport v-SNARE N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731564.1">
        <property type="nucleotide sequence ID" value="XM_001731512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVB8"/>
    <dbReference type="FunCoup" id="A8PVB8">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVB8"/>
    <dbReference type="GeneID" id="5855861"/>
    <dbReference type="KEGG" id="mgl:MGL_0832"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0832"/>
    <dbReference type="InParanoid" id="A8PVB8"/>
    <dbReference type="OMA" id="SKMRQHK"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vesicle transport v-SNARE N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="187" mass="21472" checksum="2A91C4D784EC65C6" modified="2008-01-15" version="1">MTDLFESYASDFAQLRQSIENRLAVDFSSMSAETRHSALRHADAEAEEAGELVSQMEIEVQSFPSAVRDRYVAELRALKHSLEKLQQDIYRDSDLEANDDVQQRQRLLRGTDVLERGSRRLADSTRLAMETEDIGANILQDLQRQREQIEHSRDTVCAKLVAPISNFCFSYMEQIHTLIGRHGRCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVI1</accession>
    <name>A8PVI1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0874</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731606.1">
        <property type="nucleotide sequence ID" value="XM_001731554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVI1"/>
    <dbReference type="STRING" id="425265.A8PVI1"/>
    <dbReference type="GeneID" id="5855912"/>
    <dbReference type="KEGG" id="mgl:MGL_0874"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0874"/>
    <dbReference type="InParanoid" id="A8PVI1"/>
    <dbReference type="OMA" id="FYIRESF"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="442"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="553" mass="61775" checksum="21B7F3F83E463F1C" modified="2008-01-15" version="1">MTIYDHLGVGFGPANLALCISLYENADARASRFTMCFIERQPVFAWHPSLLLPGAQLQVSPLKDLATMRDPTSSFTFLNFLHEHGRLMPYINREEKVPSRREWSAYLAWAAKRMDSFVRYGRQVVDIVPIEENGSFSYFQVECLENSTQKREAFFARNVSLGVGGWANIPDVFQPMYKHPLPASEAVCRVVHASSFLPQMMHLGPVLNATQLSSRPLRLAVIGGGQSSAEMLCYLRHHYPQAALDMIFRAPALVPSDDSPFVNAAAFDPSSVTTFWESTASQRRRQLAEFKRTNYSVVRNDLLSELYEIVYDQDVNYREPLEEDMGLVCILASTELVRAEQLPDGRLQIDTRTNVGERLERTHTYDAVFLGTGFQRDPAQLPFVRTLANHFPLLSQQGSAQLREQELALDDQVSLSQDPDSLRAQLRGITRDYRLVPSDASQWKLPLTPPSSTIQHIPRSQLGREGRREPTLSRHNARWPPASSTHPTSESTSTSTSTSTSTSSAPLKPMAGAVFLFGCNEPTHGLSDSLMSMVAHRAGIVTASLLYGMQAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVK0</accession>
    <name>A8PVK0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731623.1">
        <property type="nucleotide sequence ID" value="XM_001731571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVK0"/>
    <dbReference type="STRING" id="425265.A8PVK0"/>
    <dbReference type="GeneID" id="5855929"/>
    <dbReference type="KEGG" id="mgl:MGL_0891"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0891"/>
    <dbReference type="InParanoid" id="A8PVK0"/>
    <dbReference type="OMA" id="WRCLEWM"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36635" checksum="65A3C530F747D25B" modified="2008-01-15" version="1">MAPALATRPRCPPVSVPWISRRPSVTAHWSRAQSGSNSASLLPPSLSGVLNRAIKNELKKNRHSRNAGLNGVGLGCGPWAGNQVLKRCQQKLQAQRAQRIEQRKQLKRERKARGLKNASSGGSASSETAGSDGADSVASELSTASSSSSHPSTPPSEADNGAVGLTLTETSKVNVNAKTKASATCPQTTAVAYRKVVARRSQPIMTDSRVRGADLYVVRLLQDTESKAKAKEQRRRQHGFTSSRIPIPTVEPRYADSRPCWRCLEWMYWAGIKRVYWTDPDGDWYGDKVAHLLFGSTSHDSSSATTVYVPVHLTQYEHAAAMLRIKAGSSSTSNVACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVP4</accession>
    <name>A8PVP4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731654.1">
        <property type="nucleotide sequence ID" value="XM_001731602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVP4"/>
    <dbReference type="STRING" id="425265.A8PVP4"/>
    <dbReference type="GeneID" id="5855959"/>
    <dbReference type="KEGG" id="mgl:MGL_0922"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0922"/>
    <dbReference type="InParanoid" id="A8PVP4"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="140" mass="15226" checksum="AE03402359BE5A17" modified="2008-01-15" version="1">MPKRPESDSQPLTINLQNSNDLSFNESHTAGDPDSSNDGPRPPPIFVGPTPLNTPTDLSPTYDQSQENNLRKAILKSQTNHTGAIVAPSSNFPPVPLSEDYVEEHEGGLIASAVEIINTARDLFGVIIGSPRNMSRSWYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVS8</accession>
    <name>A8PVS8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731678.1">
        <property type="nucleotide sequence ID" value="XM_001731626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVS8"/>
    <dbReference type="FunCoup" id="A8PVS8">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVS8"/>
    <dbReference type="GeneID" id="5855983"/>
    <dbReference type="KEGG" id="mgl:MGL_0946"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0946"/>
    <dbReference type="InParanoid" id="A8PVS8"/>
    <dbReference type="OMA" id="QANCINI"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="554" mass="59484" checksum="D0A8A26921A0020F" modified="2008-01-15" version="1">MTKQAQEHAAARASPSAARALLALQIGLRLLTFVLNQVLVRTTPPAVFGAANVQLELVLSTVLSLSRDGVRAIMMRHRESLRKHGATGMLHNLALWPVGLGGVLAVLVGWMYMAYLAPTDLWIEGGASVYLSVVLYCAGAWIELAAEPLHTYALGLDREYVTMRVAMEAGGVLTKSLVNVLLLQPACLAWMSRVLSPYIPLPPTPIPYALLAFALARLAYGCAVLAIAIAGVARICGSWRKALMTLAPERAPWIDRPMFAFLRVTTGQALLKLLLTEGDKLAMARWTSLDDQGGYALASNYGSLVARTLFQPLEESSRLRFSRCVDEQQDAEQTAAAWADAAEFLGALLHMHLLFGLGLVALAPPISRPFLRIVAGARWTLPTSPAARILASYCWYVPVMGVNGLVEAFVQSVAPPAVLQTYSSVLMGSSGVLVGVLGLHKYVAMGLAPLGWGAESVIVVASMASLGVRAYASARYVVRAFEQRARSAPSLAAYRTSVSAVCPHVGVIAVLGGCAALLRLRLSLTSFGTCALLAMLCVWHWERVACVNAWRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWR5</accession>
    <name>A8PWR5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. uL22 is associated with the polypeptide exit tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731924.1">
        <property type="nucleotide sequence ID" value="XM_001731872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWR5"/>
    <dbReference type="FunCoup" id="A8PWR5">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWR5"/>
    <dbReference type="GeneID" id="5856229"/>
    <dbReference type="KEGG" id="mgl:MGL_1192"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1192"/>
    <dbReference type="InParanoid" id="A8PWR5"/>
    <dbReference type="OMA" id="NTYETAR"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000012">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21887" checksum="DE4BAB0C0E2B114A" modified="2008-01-15" version="1">MQTRYAFDDSKLPETTAKSRGAYLRVHFKNTRETAAAISGMPLQKAYEYLGNVVEHKQAIPFRRFNGGVGRTPQVKDFNTTQGRWPVKSVKFLLGLLKNAEANAEAKGMEVESIIIRNIVVQQAPTTYRRTYRAHGRINPYRSSPCHIEIHLSTPTEQVQKTKDAVVTQRLNKRQLAKKRVAAARAITAAPLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWY2</accession>
    <name>A8PWY2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731990.1">
        <property type="nucleotide sequence ID" value="XM_001731938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWY2"/>
    <dbReference type="STRING" id="425265.A8PWY2"/>
    <dbReference type="GeneID" id="5856295"/>
    <dbReference type="KEGG" id="mgl:MGL_1258"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1258"/>
    <dbReference type="InParanoid" id="A8PWY2"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="600"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="907"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="698"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="827"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="863"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1113" mass="124402" checksum="ACB13D8C0AC4B89A" modified="2008-01-15" version="1">MTVRIHEADGTPYEHVLDIKNEHQRYDVPFNTKYKRVRRNTKRFQARQAAAAAAAAGDEDAAEAIGMIDLGFGLGMWEDEDERKRWRVADWTEEDEAIMASAPYEWIRLDADFEWMAQIQFEQPDYMWVSQLQRDRDVVAQLAAVHALSQMPSLITSSTLTRTVLVTKYFYRIRAEAAYGLANCALPHLDLLGLFHLFMLFRTSYCLDVPHEGDSTSLEAPCIPKPNDFSDMADYFVRRALIHAIARVRDHRGRALVIVQRFLIYLLRYNDNSTNRFVDDYYLASIINALAGTLIPIDSAGYSTHADETYSPEEMELRAVAIQEVERLQVLDRLVPSYHNVVTIAALDFHQALVFANLRPLELVHFLEYTREGNFPPVRMAALNALLLLRGLQHKVLTRYYFAILASDEDHVIRMHLARSLCDALAVAIATGELGITRQRHEMLQEGDPLGNVAEQEALLADEAAQNEQMIKVLRREIGRSASVRDGFLAAFRASKDQAVARWALMRLAELLFKPVEDTKVPTEQTTVSVPAGEQTGAMRIRLMIKNAPQQEKRSTSHPLRVVLPKTAKPKKPKAPEPGQALGMSSSDFSACRMCIQKLMANKHCEPFTRPVDPVRDEAPDYFDVIKEPMDLSSVSNKLQSGQYKDRFQFKDDVDLIFQNAKTYTPDPKAWIHYEASRSESAFRQLWNRIGKALEQAAARAEKHSTDDVDEASAPKQPPSAAAAAGILPTSVCTTAPNGSTTSDTSDPVSSAPPPKKITIKLNVGKGEKRTASEAPPRPTLKVKRPRSEASSPPPRPPPAAAAAAATAAPGELESSASIKQSSAGVKSSTSAKPSSNTSKSSAKSKSQNTTKPSAIAPSALEPKQEPMAETIDPDKAKSASEDPVLPGEQETPLHMKKVRSVLQAIYRTKEAAIFYYPIDPVRDNAPTYYEEIKHPMDLSKIDRKLKAGEYKTMGDFAADMRLMFANCRQFNPPGTEPAIMEQAVSRVWRREWSRAMVRKLEYSHKRSLQSMMGRLKQHPTGGLFLYAVDPVALGIPTYFDVIPQENARDLTLISDKLRSDRYDSIDALDADIQLMLSNCFTFNAGNEVVCDIARAFEKVYQQELRALRKAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWZ9</accession>
    <name>A8PWZ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1275</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SQRD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732007.1">
        <property type="nucleotide sequence ID" value="XM_001731955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWZ9"/>
    <dbReference type="FunCoup" id="A8PWZ9">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWZ9"/>
    <dbReference type="GeneID" id="5856312"/>
    <dbReference type="KEGG" id="mgl:MGL_1275"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1275"/>
    <dbReference type="InParanoid" id="A8PWZ9"/>
    <dbReference type="OMA" id="ERYSMFI"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="12">
        <location>
            <begin position="34"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="616" mass="67851" checksum="62D6DCBD0412AA55" modified="2008-01-15" version="1">MMLAQVMRKAAMPQRIGNVSLFSTSARVLDAAHKVVVVGGGTAGLSVSHQLLNTGKFAQDEIAIVEPSNFHDYQPGWTLVGGGLKTRESLRRNEDSLVNSKIQLYKDAVTTISPEQSQLTTASGKKLDYEHLVIASGYTVTLDGIKGLREALHDPNSSVCSIYTYESVQHVHPKIDKLKEGQAIFTQPGSPIKCAGAPQKIMWLALDKWTKAGLYKKHDASSPIKISFATGMPTMFSVPHYSKVLDGLREERGVSGFFQHNLVAIEDQGKTAVFQRPNGDQVKMPFDFLHVTPTMSPPEFLRKSPLANGAGYAEVDQAKLQHVKYSNVWSLGDSSSLATSKTAAAITGQSPVLVANLLSALEGKELTATYNGYTSCPLLTEYGKVLLAEFKYGAQLNETFSKYGIDQSKPQRAFYYLKKDFFPWVYYRNMVKGTWAGPKGFLGTIRTFSSSARKMRNTPARHPRDPLDTSVHASRFSLPTRETFVVRPAPSQPSSRMSVPAAETLFAAPAPISETELAGLPPALRKHHRQARLATNVLSPEKVAELQQLRAQDPFKFTAGKLAKMFGCSPTFVSIVAPAPKNVRKARQAETELKRATWGMNKRVAHEQRAERRALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX16</accession>
    <name>A8PX16_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732024.1">
        <property type="nucleotide sequence ID" value="XM_001731972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX16"/>
    <dbReference type="STRING" id="425265.A8PX16"/>
    <dbReference type="GeneID" id="5856329"/>
    <dbReference type="KEGG" id="mgl:MGL_1292"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1292"/>
    <dbReference type="InParanoid" id="A8PX16"/>
    <dbReference type="OMA" id="SASIECG"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="143" mass="15815" checksum="0A9362062F5EE841" modified="2008-01-15" version="1">MGGEPPICEQKDVVYLTADTDNTIDILEPGKVYVIGGIVDRNRYKHLCAKKAEALGLSVARLPIDPSYLDGQKMQARKVLTVNQVFSILIGWTETRDWTAALKRGLPTRKFDTVIGNELEKDEVECSNQDDNESASIECGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXA7</accession>
    <name>A8PXA7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731200.1">
        <property type="nucleotide sequence ID" value="XM_001731148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXA7"/>
    <dbReference type="STRING" id="425265.A8PXA7"/>
    <dbReference type="GeneID" id="5855507"/>
    <dbReference type="KEGG" id="mgl:MGL_1383"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1383"/>
    <dbReference type="InParanoid" id="A8PXA7"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="161" mass="17768" checksum="DC1B73BD3FE99BAB" modified="2008-01-15" version="1">MDHPDVYGGRKAVTSKTRQDAAVSEAKSSAESAGKGGKQVKSAVSAAASSIEPFTPSPSVLILTVLIIVLLISNVWVYMRGSPGSMRDPNNPHRLLIPTRPKQLDMRQANVVLQDEVQNLLDTLANSRRITEEIELDLRELQKFIQKESKHRHSRTASTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXB9</accession>
    <name>A8PXB9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="15">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_1395</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="15"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731212.1">
        <property type="nucleotide sequence ID" value="XM_001731160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXB9"/>
    <dbReference type="STRING" id="425265.A8PXB9"/>
    <dbReference type="GeneID" id="5855519"/>
    <dbReference type="KEGG" id="mgl:MGL_1395"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1395"/>
    <dbReference type="InParanoid" id="A8PXB9"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF153">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="17">
        <location>
            <begin position="226"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="642"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP43998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="705" mass="79360" checksum="86F24CCD741E57FD" modified="2008-01-15" version="1">MEALADELERDFILLGATAIEDRLQDGVPETIADLKRAGINIWVATGDKLETAIAIGYSTMLIAPDMNLIVVRGGEYGSKHSAYTQLEMAMDRFFGGIDASEMEHPPPPSMVDTFDGQSVMTNTSLVGEENGSRPGGYALVIDGHALSFALNEPHSRELLIRVSKNCRAVICCRVSPLQKALIVRLVKQGLNGITLAIGDGANDVSMIQAAHVGVGVAGEEGLQAVNSADYAIGQFYFLKRLILVHGHWSYYRNSTMVNVFFYKQMVHTGTLFWFQIYCAWSTSQAIDYVYLLLYNAIWTVAAVIGIGIFDRNVSDHVLMQVPELYGVSRKQQYFGMWRFLGYMLDGVFQSVVLFFLLMYFYDTTSTRIDGYDIDLYEPTTNMVLSTVLAANLYAGIESMAWTWWIFGVVWIPTLLLFVFEPIYAAFPPTLIWTHSWGNNYYLYRSAQFWVGGILTAFLSILPRILYEYLRIHFFPTDVDILHYIDARDPNHDYVHDPQMPGLRAAQAYESEVDADASRAPVGDTYPLMPTQSRTSSIYHDMSTGEARPYRGYSFSASDKPVPKPKKVMRRLKQIFKPHGKRKHSDFSYVRSSQTRDDDIVERKEPLHVDDATDVDGMKHQSYLDDGVIFAESSGDEQHTRFHTAFSAPPPSDFPYGGYPSLQQEQQGHLPQAPPLFVPVHGPIPSSSEAYYTAMEHNGSRQVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXD3</accession>
    <name>A8PXD3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_1409</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731226.1">
        <property type="nucleotide sequence ID" value="XM_001731174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXD3"/>
    <dbReference type="FunCoup" id="A8PXD3">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXD3"/>
    <dbReference type="GeneID" id="5855533"/>
    <dbReference type="KEGG" id="mgl:MGL_1409"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1409"/>
    <dbReference type="InParanoid" id="A8PXD3"/>
    <dbReference type="OMA" id="YVDYYPQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="179"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="323"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="594"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="787"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP44012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="811" mass="90643" checksum="EFA524E72F238367" modified="2008-01-15" version="1">MLLDIQRKFFSRSERVKSVDFHPTEPWLLAGLYDGTVFIWNYETGAVVKTFEVADVPVRCVRFIARKNWFLAGSDDFFLRCYNYNTHEKVAAFEGHPDYIRSIAVHSTGPYVLTGSDDMTIKLWDWERNWRLVQTFEGHTHFVMSLCFNPKDSNSFASASLDRTVKVWTLGSPMANFTLMAHEKGVNSVDYYHGGDKPYIVTTSDDKTVRIWDYLSKSCVQTLTGHMSNVSFAVFHSSLPLIISGSEDGSVKLWHANTYRLESTLDYGLERVWCIAHRKSSHDIALGYDEGAVVVKLGKEDPCMSMDQSGKIVYARNAEILGANLATTSESELVEGERVRLSTRELGTTEVFPQLLEHSPNGRFVTVCGDGEYTIFTALAWRNKAFGSALGFAWASDSNTYAIRENSTTRVRVFKNFKEQSGLVLVNYVVEGIAGGALLAVIGVGFVCFYDWVSGTLVRRINVDARQIFWSQTNELVVITTVDSFYVLRFQRAAYEAFVESGMPSDGDGFEDAFDVIAEVNETVRTGRWTGECFVYTNAANRLQYFIGEQTYTIRPCDTELYVLGYLPQLSRIFAADKDMNLYSFSLSLAVVEYQTAILQGNFALAESLLPQVPHGQRGKVAKFLETQDMPDLALQVATDPDHRFDLAVQLGDFDIALDIAHHGPTSGAESRWRTIGDQALARWNVPLAQECFEHANDVHSLFLIATAKQDDALLRTVAAAASDKGELNLAVAALLQVQDTQGVVRVLQRAERLPEAALFARTYAPHLVPEAVRAWKASLASQKSQKQQQMSERIGDPLSIPELFPEGGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXR8</accession>
    <name>A8PXR8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731327.1">
        <property type="nucleotide sequence ID" value="XM_001731275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXR8"/>
    <dbReference type="FunCoup" id="A8PXR8">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXR8"/>
    <dbReference type="GeneID" id="5855634"/>
    <dbReference type="KEGG" id="mgl:MGL_1510"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1510"/>
    <dbReference type="InParanoid" id="A8PXR8"/>
    <dbReference type="OMA" id="QMMFVFA"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="286" mass="32327" checksum="62B4F3BF2FA3795E" modified="2008-01-15" version="1">MSKYLAPEDLIFLIRYDRAKVNRLRTYLSWKDVRKNAKESGGDSAGTGGGGAGAGDGGDGIDEAGEDTPLRVNKRKMRLPWDLGSIFSEFPRVSGQAVEDAEDDDDDANETNEDSIRRLKAADETTRRMTREEYVYYSECRQASFTFRKAKRFREFIHANLYLDVKPSDDTIDILGFLAFEVVHELCTRAMRIKRDWEQRAKTLRTRRNAKATDPSFSSSPLSSEDHEHQEACTLFRLPADSEPPLEAWHIHEAFTELQSKHSFVDTGRGAAGPAGGLRRTQVFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXX5</accession>
    <name>A8PXX5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1546</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731363.1">
        <property type="nucleotide sequence ID" value="XM_001731311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXX5"/>
    <dbReference type="FunCoup" id="A8PXX5">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXX5"/>
    <dbReference type="GeneID" id="5855670"/>
    <dbReference type="KEGG" id="mgl:MGL_1546"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1546"/>
    <dbReference type="InParanoid" id="A8PXX5"/>
    <dbReference type="OMA" id="FDTIPQE"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="14">
        <location>
            <begin position="512"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1023" mass="116254" checksum="C8C56B62EBEC29E1" modified="2008-01-15" version="1">MNPVTPGLVARHLLPTYYAKVVPLRTYLSEVSPSSLVPCNESFHDAATDSAAWQLILDGLVAMPNGIDAPSSREGGYGLDSLNHVDNHAAVLHNVLEQAQYAIYTQRRRDILLLGFHYSAGRLVRTHWNSIVQTFLENPAWHLLLQRMGSTAFMRLLCSTAYFFPAAPDHDCYVQMWGIPLTELPPPSTSVEKMTPSRSVHAAQIYLRRSRLFHARATHVYRYGIALGLPPTHAFHLPMRWSQMSHMERRMHTARILRDMMPHDFGYPFGWERAHPTHSPRRRRWPKGLGCLSRFVACMLRRHDKCRYDMILDACCPTVLPRGRVLRARRMEVVSQFAGLDPQAASASTSTTPGSTCASALSAPYVPHGMPPFLHYATPPGRVVWFVCVVLRKLLPSAMVGSQHNWAIIRRAVHQFVHARRFERVTLHDTLQGFKSRDCGAWLAHRDPTQTQMRLCSWMWWLMDALVLPLLRTSFYATETAVFRRRVLYFRQDVWVRVTTPLIRDLCTQRFSRVSAVPRDGRVPYATVRLLPKETAVRPIINLGRRPQGFGRSINAQLQNALAVLTYESTQQSHMCGAAISSVKAMYAKLKMYKDHVFSHGSRRLYLVRADIRAAFDSLHHTRLLELVRMLLPRHATYVIQRYAQVRPGIGLIRRCHTRRAYPAETSPAFMKHAAEQPSRHAVLVDGITYTTVSATDVMKQVEAHVKQTFVRFGDALYRQTTGIPQGSILSTLLCNLVLADAERTYLYTESRPGAKEQPVSDADDCLLRFTDDFLYLTPSLERAQRMCVALHAGFPLHGCQVAREKSLVNFDAYLPDGYVVRRVAPHVPFPWCGVCIDPTTLALLPDPDRDPHHLGDTLTIRRITGLAPMLLHAMHARTRFMFTDTHLNTTDGAYTNLLEGFVVAAAKLHVYLRSMTHVHVLHVQRSVVRAVRSIYPMVRASLREAQVSFSTVSDVQLRRDCIEWLGFFAFARVLQRWQVHSALASAFANYMQAPQYARARGKIGRLAISAWTTHRQRIAQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXX8</accession>
    <name>A8PXX8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731365.1">
        <property type="nucleotide sequence ID" value="XM_001731313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXX8"/>
    <dbReference type="FunCoup" id="A8PXX8">
        <property type="interactions" value="549"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXX8"/>
    <dbReference type="GeneID" id="5855672"/>
    <dbReference type="KEGG" id="mgl:MGL_1548"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1548"/>
    <dbReference type="InParanoid" id="A8PXX8"/>
    <dbReference type="OMA" id="PYVQRHF"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="344"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="391"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="500"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="542"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="7">
        <location>
            <begin position="641"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="842"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="843"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="885" mass="96803" checksum="CE8998653D161835" modified="2008-01-15" version="1">MITASRSLSLHVYALADMERVRTISKAHEAPVALMAVDPTSSLLATGSADGSVKVWDLRGGYCTHVFRGHGGVVSALCWHVESRRAGSSARGVQLITGCVDGKVRVWDLRGGAKAASKPTAVLHAHAGVVRGIGISSDGNTIVSGARDQTLVFWDWKEGRWTRRDIQLIHERIEALKFLPGTPWFATAGSKGILRVWDVSSGSEVTRQESTRETDSGAGWVSATHRGDNAHGDGHEHGGGGKDDVDDDDDDDDDELRGLMDALVSSESHAIVTVSATQDLAFFALHASSDTEPQLVQTHQLVGYNDEIVDVTLLEQQKFLAVASNNSQLRIYKLDTHDHDVSLVDGHADMVLSLDASPDSKWLVSGSKDQTARIWARVDDGRDSWTCLGICEGHAESVGCVKFARKSLEMTPFVVTASQDRTLKLWDLSQLTDDNRFTKLSSLITLKIHEKDINAIDIAPNNGLLVSGSQDRTVKVFRLNYTAPGKHTKPSATLDTLATCRGHKRGVWSVQFSPAEQAFASASSDQTVRMWSLQDFACVRVFEGHTGSVLRLQYLPSGAQIVSSGNDGLVKVWNVRDEECAVTVDAHEDKIWTLAVREETASTPLQIISGAADSTITLWSDTTAAVEAEKMAVAKEAVEREQQFTNLVLLKDYRNAIALAFQLDQPRRLLQLFSQVATSRPDYDAMASMDRLLADALGTRHVRGAAHDEDEDEDTRRGSITGLAAVDGILQTLPRSQLVQLLSYIRDWNTSSRTSPIAQLLLHAIVRQWDAEAILDAFEEARKQKDSHTGHAHGMSALSMLDGLMPYTERHYARVDRMLVESAMLDYTLQAMDSVLGVHGEEAMDDEGDMEEPSSRVLTDTARMDDDANDSDSDSDDAAMDESHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY51</accession>
    <name>A8PY51_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731409.1">
        <property type="nucleotide sequence ID" value="XM_001731357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY51"/>
    <dbReference type="STRING" id="425265.A8PY51"/>
    <dbReference type="GeneID" id="5855716"/>
    <dbReference type="KEGG" id="mgl:MGL_1592"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1592"/>
    <dbReference type="InParanoid" id="A8PY51"/>
    <dbReference type="OMA" id="HNLADCF"/>
    <dbReference type="OrthoDB" id="10267182at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="234" mass="26556" checksum="19FA48078E7D57FF" modified="2008-01-15" version="1">MVDQASLAVHSIVLEDPPLDFEPLPAVSSQLVVFDFDWSLADQDTDRWVHEVLSPQRRIEFVQLKPTMQFTDMCALLLEKLHEEGHSREALEDALRKMPMSKGLADPPLFTEIVTNPAHWEPNGLLRLTRRIPPDGPQHSCRVGCSANMCKGDELDAFQQRHADRKYERIVYVGDGGNDFCPIQRLGPNDVAFVRRNRGLAKRILDEGGVQCTVRYWSGAWEAEQLLKLLSIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYI9</accession>
    <name>A8PYI9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP11-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731488.1">
        <property type="nucleotide sequence ID" value="XM_001731436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYI9"/>
    <dbReference type="FunCoup" id="A8PYI9">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYI9"/>
    <dbReference type="GeneID" id="5855795"/>
    <dbReference type="KEGG" id="mgl:MGL_1671"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1671"/>
    <dbReference type="InParanoid" id="A8PYI9"/>
    <dbReference type="OMA" id="FLQWGFH"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39896" checksum="1B2623B69A9F192B" modified="2008-01-15" version="1">MFSLRTVRTRNIVVPLRCTYRCVHVSLVQRNIPKAEELLDQFAQGNDKGASVTAKRQAYLNKYNDKLREKIAKEGFKSVDDMAASKRAAEAKVRETQRESESHPGTSVEARDEALREKLSEKRRATENSKLMDDSGSPSPVQPLSSFMKLEKVVHETPDNIGKLWAGFHIMKNKVSAVVPAATYVQMIVTAKKFPQFVLPLPRAVKNEAGNAENGYEIYYLQWVSLPKPKEASSNAPPPMAVLFTPLAEYKLRQEYAQPTLVLTHYTELLESKGIALMRGDITESENGKVHVQQQDAQLLALGLQRFYNLDWALEGLDNDEEAEKRRALLRSFYERPEAFKLEDLIELAWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYT2</accession>
    <name>A8PYT2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731537.1">
        <property type="nucleotide sequence ID" value="XM_001731485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYT2"/>
    <dbReference type="FunCoup" id="A8PYT2">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYT2"/>
    <dbReference type="GeneID" id="5855844"/>
    <dbReference type="KEGG" id="mgl:MGL_1720"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1720"/>
    <dbReference type="InParanoid" id="A8PYT2"/>
    <dbReference type="OMA" id="RMSAKFV"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="76"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="182" mass="19965" checksum="1A371501977EEA12" modified="2008-01-15" version="1">MFGVATSRFLRPATLTVPKTQIYRAMGTVATNSMRSGFSKDRLSEASTSSSSDSVADKRSKVSEKIQARAQKKAAIKLTPTAVEHIRKLLSASDGPKLVRVGVRNKGCAGMSYHLEYVTPGEEGRFDERVMQDGVEVLIDSRALFSIIGSEMDWKEDRMSAKFVFNNPNIKDACGCGESFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZE8</accession>
    <name>A8PZE8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1913</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730914.1">
        <property type="nucleotide sequence ID" value="XM_001730862.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PZE8">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZE8"/>
    <dbReference type="GeneID" id="5855221"/>
    <dbReference type="KEGG" id="mgl:MGL_1913"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1913"/>
    <dbReference type="InParanoid" id="A8PZE8"/>
    <dbReference type="OMA" id="LTTCFQD"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="788"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="870"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="950"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="974"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1083"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="152"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="488"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="816"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1146"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1415" mass="157361" checksum="BC1C46398D5802AE" modified="2008-01-15" version="1">MCSNMRTAWMHTASTLGLVQGVAAIAVLLGLLLRRQMFPQPDRVKQLRFVHSSTGMDPASSAQLKPKVSNDEPSPESFTSVLGRITFLFMTPFVWRQYFHPTTFASIPQLPAKFRAATIVARVRLATGTKRESLLARLWHVLGPSITYQLTLSFLRACFRVVPIACLSQLLTFMTLRDEANAHGMSRPPPMHAGLFWASCLFAAQLTEFLLDINVMQHGRSQSVELRAYLSTELFSKILRRVVHGTPLASPASSSSSERLTDGHIASLLSVDMFKIDSFLAFLHQPLVDYPLTIIFCCIYLFRLLGVSALVGLSVLLITAPLQTQLSKLMVRLQDHILQATDARLDLVNEVLTCIKTVKFFAWETPFLERLRASRARELIMLARNNLMSITYNFIFVGMPMVVTMATFGTYTYVLGHALTPKAAFTALSIFTTLRMPLSDYPEMIVSALAAVVSVRRIDGFLRTENTHKYDQLMTMNDSAPNRHPTYLGFLDASFAYDPHDPEAFRLLNLTCRFPVGQLSMVLGPVGSGKSSLLLALLGELHRLHGSTVLPCPTARSMTLADPTTLLTESTAYCGQNAWLLGTTVRENILFGSAYDEPRYREVLRACALEPDLDILEHHDETEVGEKGTSLSGGQKARIALARAFYSYAKHILIDDALSAVDAHTGEHLLRHCFHGPLSRGRTIVLVTHAVPLVLSHATYAVILDHGRVAAQGTPTDLVRAGHINSTIQYPDEQSRPLPPTVSEDKGMESKVHDAKWIEANERRARKNQNARAESIQRKARGMDLYFMYARSVAVHTSVAIGLWMLLMSLYASVRMADVFSNAWLKQWANSYSSASQALLDPVFHALDSMLAFLRSAYAAPTDPHEKATLYYLVHYIVLVVFFILLSTLRDCVQYYIALRASRLLYARLLHALLYASPRFFDITPIGRIMNRLSKDVETVDQDMTPSLRMMIEASIALAAILGIICWATPKFLYMAGFVMVMYYIIGALYLGSSRQLKRIESIERSPLFTLLGETLAGTVTIRAFSDGERVIRRCMHVLDRTHRAFLYLWYENRWLTLCVDLMGAIVTYTTAILLVITGADAALTGFTLAYAVLIVQTVLRIVRRYTTTEINLNSVERIQEYLHVPSEQQGGKKPPAHWPTDTCPIQVRDLSVRYSPELPLVLSNVSFDIQPGHKVGIVGRTGSGKSTLSLAFFRFLEAESGSIIIDGIDISSISLESLRRRLTIIPQDSQLFRGSIRSNLDPFGLTDDGDMWFALQRCQLAVPGSSPNVPGEGSVIKSLDDAVEQGGSNFSAGQRQLLSLARGLLKMRESRILILDESTANLDAESDALIQRTIREQMAPGATILTVAHRLKTIIDYDKVLVLSNGHVVEYDAPVKLLDNEQSTFYALCERSGELQHLKAAAATAAASKVRPDP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-11-07" modified="2025-02-05" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZM4</accession>
    <name>SEAP1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Secreted aspartyl protease 1</fullName>
            <ecNumber evidence="4 5">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SAP1</name>
        <name type="ORF">MGL_1932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2018" name="J. Invest. Dermatol." volume="138" first="1137" last="1145">
            <title>Skin commensal Malassezia globosa secreted protease attenuates Staphylococcus aureus biofilm formation.</title>
            <authorList>
                <person name="Li H."/>
                <person name="Goh B.N."/>
                <person name="Teh W.K."/>
                <person name="Jiang Z."/>
                <person name="Goh J.P.Z."/>
                <person name="Goh A."/>
                <person name="Wu G."/>
                <person name="Hoon S.S."/>
                <person name="Raida M."/>
                <person name="Camattari A."/>
                <person name="Yang L."/>
                <person name="O'Donoghue A.J."/>
                <person name="Dawson T.L. Jr."/>
            </authorList>
            <dbReference type="PubMed" id="29246799"/>
            <dbReference type="DOI" id="10.1016/j.jid.2017.11.034"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 89-395</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2024" name="Biochimie" volume="216" first="181" last="193">
            <title>A Malassezia pseudoprotease dominates the secreted hydrolase landscape and is a potential allergen on skin.</title>
            <authorList>
                <person name="Chua W."/>
                <person name="Marsh C.O."/>
                <person name="Poh S.E."/>
                <person name="Koh W.L."/>
                <person name="Lee M.L.Y."/>
                <person name="Koh L.F."/>
                <person name="Tang X.E."/>
                <person name="See P."/>
                <person name="Ser Z."/>
                <person name="Wang S.M."/>
                <person name="Sobota R.M."/>
                <person name="Dawson T.L. Jr."/>
                <person name="Yew Y.W."/>
                <person name="Thng S."/>
                <person name="O'Donoghue A.J."/>
                <person name="Oon H.H."/>
                <person name="Common J.E."/>
                <person name="Li H."/>
            </authorList>
            <dbReference type="PubMed" id="37748748"/>
            <dbReference type="DOI" id="10.1016/j.biochi.2023.09.023"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Dominant secreted aspartyl protease that has a clear preference for aromatic residues in the P1' position directly adjacent to the cleavage site and, in particular, Trp (PubMed:29246799, PubMed:37748748). In addition, it generally cleaves peptides containing Lys, Arg, Phe, Tyr, or Nle (norleucine) in the P1 position, Nle and Glu at P2, and Arg and Val at P2' (PubMed:29246799). Has important roles in facilitating the interaction of the yeast with the external environment (PubMed:29246799). Is able to rapidly hydrolyze Staphylococcus aureus protein A, an important S.aureus virulence factor involved in immune evasion and biofilm formation. Shows anti-biofilm properties and thus plays a role in inter-kingdom interactions, beneficial for host skin health (PubMed:29246799).</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="4">Inhibited by pepstatin A.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="4">3.4 uM for peptide RPKPVE-Nva-WRK</KM>
        </kinetics>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Highly expressed during exponential growth in rich media (PubMed:29246799). Also part of the 3 most highly expressed extracellular proteases in minimal media (PubMed:29246799). Expressed on human skin (PubMed:29246799).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="4 5"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730933.1">
        <property type="nucleotide sequence ID" value="XM_001730881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZM4"/>
    <dbReference type="SMR" id="A8PZM4"/>
    <dbReference type="GlyCosmos" id="A8PZM4">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="5855240"/>
    <dbReference type="KEGG" id="mgl:MGL_1932"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1932"/>
    <dbReference type="InParanoid" id="A8PZM4"/>
    <dbReference type="OMA" id="LSECHTR"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000445601" description="Removed in mature form" evidence="4">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727153" description="Secreted aspartyl protease 1">
        <location>
            <begin position="89"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="105"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="29246799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="37748748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="29246799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="395" mass="43273" checksum="288119C61EEFEFA9" modified="2008-01-15" version="1" precursor="true">MQLSIQAIIGFVVAAGLAVASELPSPMTVNLERRKMLVTKNDTVDFKAVRKQANALNYKYDKLLRNFRKNTGRDHPLLHLLLDLIDKRDGKGDVDLDDIGEGQLWAGDVQFGQSKFKIDFDTGSADTLVNPFVYFPHRSKSSRKTHHTFSTAYGDGTTASGFIYTDDLKIGGYKAKDVAIGLSVTKFINDEDNQGIAGMSFPAVQSFPKKFDPFFVALVKQKVVPEPVFQFTLKRGSGSTLHLGGIDNSRFQGELSYVDVNPEDGFWISEGKVNGKKIDACIDTGSSIIFGPIDEVREVITKMDGVTPFTAGGALHGAFDCSKPPKLDFEFAGQKFNLGENQVSFGKYQGQCVLSIMGQKNLPMNAWVVGDSFLQTASVVFDMGKNRMGFAPSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZU7</accession>
    <name>A8PZU7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730952.1">
        <property type="nucleotide sequence ID" value="XM_001730900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZU7"/>
    <dbReference type="FunCoup" id="A8PZU7">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZU7"/>
    <dbReference type="GeneID" id="5855259"/>
    <dbReference type="KEGG" id="mgl:MGL_1951"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1951"/>
    <dbReference type="InParanoid" id="A8PZU7"/>
    <dbReference type="OMA" id="VCEAFIS"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30362" checksum="3E8D1F7709921E53" modified="2008-01-15" version="1">MSGSGRPFRTPRGHAPAWTASDHMHWHQADAFDKNSYRDLAASCTAVVHTIGILLESSYKGKGGSALGALQGLFKGWGLQSGSNPLASESKENAVTYERMNRDAALTVAEAVIEAQHRRAHDGARTPIPFVFLSAADIMRPIISSRYTSTKYEAEQRLSDMAEDILRPVFMRPGLMYHPHNRPWSTVPATMIDASNHLHRLHRRSGIPIPSPADMLRSSYMPESLRPLSGALTTPALHVDTVAKAICESIDRPDVYGAQFAESIRQLAGWPAATEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZX6</accession>
    <name>A8PZX6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1959</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730960.1">
        <property type="nucleotide sequence ID" value="XM_001730908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZX6"/>
    <dbReference type="FunCoup" id="A8PZX6">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZX6"/>
    <dbReference type="GeneID" id="5855267"/>
    <dbReference type="KEGG" id="mgl:MGL_1959"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1959"/>
    <dbReference type="InParanoid" id="A8PZX6"/>
    <dbReference type="OMA" id="WYQSTYF"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="6">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="eIF3h C-terminal" evidence="7">
        <location>
            <begin position="181"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="409" mass="44428" checksum="2BBF8259BDEFD47F" modified="2008-01-15" version="1">MSRTESIAAVARGEEASENVAPQVERGAFTEKDQENLAMDSDAITQVQVDGMVLMKIVKHCKDNHAVNGSNAWGALLGMDMGGTLEVTNAFGLPGMRSERGDEEERTTKSSMQYMGEMLRLLHQVSADINPVGLYQGAFLGPFLNTAVVDGLNTLSLLMEREGQHGRGKAVMLVHDYAQLAQGNTVLKAFRLSSSFIDAYRKGKFSSQSLIEHRLTFSNVLIEIPVHIRNSALLDAMLTTLTTEQASDARIVPPTSREELSSSLSSGHVLVPPNYMDLNLALEPVLVSTMESTLDAAETYAAEAGNVGYQARQIAREKARADAFVARRKAENATRESAGLAPLPLDEVHKLFKIPAEPNRLESLLLLNQLDSAAQRLSETAAVGAVQLDAARTGTALDRIVCERFPYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q019</accession>
    <name>A8Q019_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730973.1">
        <property type="nucleotide sequence ID" value="XM_001730921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q019"/>
    <dbReference type="STRING" id="425265.A8Q019"/>
    <dbReference type="GeneID" id="5855280"/>
    <dbReference type="KEGG" id="mgl:MGL_1972"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1972"/>
    <dbReference type="InParanoid" id="A8Q019"/>
    <dbReference type="OMA" id="KMCYVEF"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="555"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="729" mass="75935" checksum="161E6F4F9AC30AB8" modified="2008-01-15" version="1">MRTDYGVDVPSPLPTTATTAATATATAMPVAAATSPSSAVADASAGTAPMNAGLPTVAGSGGSSSSANGAGKGSGSGADEESAADAAPSSAPSGMASRRGVRANIHVIHGAAGRIACVSDIRGNMKQLNEIANATRAAAIVHTGDFGFFMPDTIGRMGDRTLRHAVQYSPLMSNKLRSVLLDSRDSRETHPPLTNGPVPTTLRQMLADHQREAVLSEFPQLLSGQLSLQVPVFTVYGACEDVDVVERVRSGEYKVPNLHLIDEATSHAIDVGALRVRLLGLGGAVVPHKLFDHGAATGSMAGGQGTMWTTMLQIGELVETAQHVYDPADVRILVSYASPGRDVLVDQLAHALQADFTMSGGLHFRYGMSYNDFGVYGQLDTYRAKILRAKEEFQDMWDAVRMQVESAIDPSQRTLLSHALHVALHAPSAPAVPAVGATSGPAAYAAAHTTPVATRAEAFKNMWHWNLPDASFGSLVMDVAHGRISTELRSQGVSFAPRRGRASMPPVKVALPAPRDHASRPGAGASAAPGVSSTMGAAAAPASPGTSASLATTLATLFLGHLGDAHPVSEQDVRVYFGERAANIMRVQFFPSERDRRANDKDEPRMRNFVHVVFKSEEAAKDALQCQGNTIKNTSVVPTLERLERSRPKTRPPKDAKSDEASSSHRPRAGRRGRGGRGGRGRNSAGASSSTTPASSAAKEAPAPAPAPAPAPAPAPAPAPASAPTQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q044</accession>
    <name>A8Q044_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730981.1">
        <property type="nucleotide sequence ID" value="XM_001730929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q044"/>
    <dbReference type="GeneID" id="5855288"/>
    <dbReference type="KEGG" id="mgl:MGL_1980"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1980"/>
    <dbReference type="InParanoid" id="A8Q044"/>
    <dbReference type="OMA" id="PAWYLNG"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="170" mass="19116" checksum="3E490F71A63376F4" modified="2008-01-15" version="1">MRGISSRPVQPGHWDPHVTRVKHPIPPLPNRKPLYIAGGASLVALWYVLSAYFNNKERVGSSVLRMVSQRVRSAPEVYELLGEPVRIKRSMFGDPWIEGIINPLKGKVDMSFEVVGPRGVGTVYFTSVRKHKTDPFELLRFLVVPHGDTSRAISLLSHGIEHNMLNSQNQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0E3</accession>
    <name>PURA_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenylosuccinate synthetase</fullName>
            <shortName evidence="2">AMPSase</shortName>
            <shortName evidence="2">AdSS</shortName>
            <ecNumber evidence="2">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">MGL_2020</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731021.1">
        <property type="nucleotide sequence ID" value="XM_001730969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0E3"/>
    <dbReference type="SMR" id="A8Q0E3"/>
    <dbReference type="FunCoup" id="A8Q0E3">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0E3"/>
    <dbReference type="GeneID" id="5855328"/>
    <dbReference type="KEGG" id="mgl:MGL_2020"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2020"/>
    <dbReference type="InParanoid" id="A8Q0E3"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000399343" description="Adenylosuccinate synthetase">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="24"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="2">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="2">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="2">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="313"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="345"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="427"/>
            <end position="429"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <sequence length="445" mass="48982" checksum="EFBADB2F594D47DC" modified="2008-01-15" version="1">MASMPKPNQSARGRVTVVLGSQWGDEGKGKLTDMLAGEMDICARCAGGNNAGHTIVANSGPDNVKTKFDFHLLPSGLVNPKCIGFIGSGVVMHVPSFFSELDTIEKKGLKCDNRLFVSDRTHLVFDFHQVVDGLKEVELGGSSIGTTKKGIGPAYSSKASRSGLRVHHLYDFDTFAAKFRKLVEGRFKRYGNFEYDTEGEIARYRAFAERLRPFVVDGVTFIHSMLSSNRRVLVEGANALMLDLDYGTYPFVTSSSTGIGGVCTGLGIPPQCIGGVIGVMKAYTSRVGAGPFPTELNDEIMTHLQEVGAEYGTTTGRRRRCGWLDLVMMRYSCLINGYTCLNLTKLDVLDNLPEIKVATTYMLGDKELSSFPADLNILAKVDVQYKTFKGWRGPISNCTSYEQLPDTCREYIEFIENFLGVHIEWIGVGPGREAMVHRPLPPHEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q103</accession>
    <name>A8Q103_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731108.1">
        <property type="nucleotide sequence ID" value="XM_001731056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q103"/>
    <dbReference type="STRING" id="425265.A8Q103"/>
    <dbReference type="GeneID" id="5855415"/>
    <dbReference type="KEGG" id="mgl:MGL_2107"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2107"/>
    <dbReference type="InParanoid" id="A8Q103"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="197"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="267" mass="29576" checksum="E0D5E512CB2AD0E4" modified="2008-01-15" version="1">MENASGGFMSDLTFHGGRFGAWMGNQQFTVRNVYFSECKTAICMHWNWAWTFIDVHVHNCEIGLELLGMFPDKQGVGSLILSDWDVSDSSVVVQLEKEGTGRLILDNMHIRDVQSIVKGPSGPLLLPKCTQDTVKFWLKAPASLPSAPSELQLRHTPDGPIYMGHISPPVRPQCLTNKKGHWFGREKPSYETWHNLVNVQKYGAKGDGVSDDTKAIQVVLDEAIGQVIFVPYGVYVLHDTLHIPTGTLMVGEAQPIFVGTGPKFQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q110</accession>
    <name>A8Q110_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731111.1">
        <property type="nucleotide sequence ID" value="XM_001731059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q110"/>
    <dbReference type="STRING" id="425265.A8Q110"/>
    <dbReference type="GeneID" id="5855418"/>
    <dbReference type="KEGG" id="mgl:MGL_2110"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2110"/>
    <dbReference type="InParanoid" id="A8Q110"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="223" mass="24890" checksum="19DA7A83F6E51F47" modified="2008-01-15" version="1">MRTLTTKSNRSVDRGQRTHNHRTKSMAPPVPSIAATDDDDVDNQVPMFPSLNSAQRHVQSHTPKGRSAQSGLSGLRVPAAPGPSRLDIPVARKKVALEPGCSPLDWARLKSTTDLRGGVTTILRITPSELKLHSSPDDAWTAIHGKVYNITPYLKFHPGGVNELMRIAGRDGTRLFFTSVRFEHLENRNFAWAFVGQSSFRHKLFLWDSPRYASLRSDQSQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1E0</accession>
    <name>A8Q1E0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730774.1">
        <property type="nucleotide sequence ID" value="XM_001730722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1E0"/>
    <dbReference type="STRING" id="425265.A8Q1E0"/>
    <dbReference type="GeneID" id="5855081"/>
    <dbReference type="KEGG" id="mgl:MGL_1773"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1773"/>
    <dbReference type="InParanoid" id="A8Q1E0"/>
    <dbReference type="OMA" id="AQNDYLD"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="501" mass="54240" checksum="7C84D4CA9F88190D" modified="2008-01-15" version="1">MADLPVSLPETEQGNTRGQVIVPPRVGERTARRQTVLDEETYTRGLSQIIQRDFFPDLPRLRAQNAYLHALEEGDVGSIESCARALVREEARAGVLEDMTRRGEAGNTLTPVAMGGDATPMSDTGFSDLDLDLTEPGHSATSTPFADAGADGSTDGSMPWPSHGKKRRFPLLLMSMDEYQTRYTTEDNASFAQLMDLDRKRRRDKYQWAYDAAHVEQAKRVARIDSARSEAEQGRQLAMPERLLIDAPASARVSHAGTPSRAVSNSAASSVSATSTTSDSVSMMPPPPPPSRKRIEARTSSSSSSQNAAPRVLHANTRLPAQEASETSEPSTPSSSVLDRAMNASSTPRIHGYNFVSATSTPRAEHMSERRLEQLMTWGQLAATPRRLDTPEPPTPSSVMTDVTPLASQTPSQTPSRTPSHMPSATPRRSSGAAPRTPSTRRLHDLSPAARSLLHRTSRSASSLYRMPSSTAASSASTATPSSSRGTPRWTPTPSPVTRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q259</accession>
    <name>A8Q259_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="10">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730690.1">
        <property type="nucleotide sequence ID" value="XM_001730638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q259"/>
    <dbReference type="FunCoup" id="A8Q259">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q259"/>
    <dbReference type="GeneID" id="5854986"/>
    <dbReference type="KEGG" id="mgl:MGL_2144"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2144"/>
    <dbReference type="InParanoid" id="A8Q259"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="11">
        <location>
            <begin position="8"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="369" mass="40890" checksum="4D7E67E38B22527D" modified="2008-01-15" version="1">MTEKKRVLIPGGAGYIGSHVALTVLNTRKFRVTIIDNFHNSKPEAVHRIEELALRELPSDASEQDKADCRIELVMADLRNPRAVENVFKDRSEHDRIHSVILIGALKAVGESAEIPIDYYNVNVGGLLNLLSAMDKYDARRLVYSSSATVYGAPETIPIPETTPMDPHSPYGRSKQICEMIIRDVCASNPAWRAITLRYFNPAGAHPSGRMGEDPRGKPGNLLPLLAQMAVGKYREPGLKVFGNDYPTPDGTCVRDYIHILDLAEGHLNAMVALDDDTKFADAKYGKCRAFNLGKGVGMSVLSMIEAMRKVTGYEFPYEIVARRPGDVPDLTANPALAERELGFKATRSLDDMCSDLWNWQKLNPNGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2L7</accession>
    <name>A8Q2L7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translocation protein SEC66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730412.1">
        <property type="nucleotide sequence ID" value="XM_001730360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2L7"/>
    <dbReference type="FunCoup" id="A8Q2L7">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2L7"/>
    <dbReference type="GeneID" id="5854719"/>
    <dbReference type="KEGG" id="mgl:MGL_2208"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2208"/>
    <dbReference type="InParanoid" id="A8Q2L7"/>
    <dbReference type="OMA" id="KPWFPAH"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22995" checksum="AD142D75A2E84849" modified="2008-01-15" version="1">MALSIFVPIAYIVTLFVSLSLFSKVYRRRALRVMQRYQAVSSQEAEIQPDRAIFKALSEIQGNYPNEPADSDEWIVPRQTLQAALLARAVAVLRSMSSLRLDKQALQSLLDRGSLGDDAATMLEAKEGEVRAEAFDVVREANRFHPAWGKLIFETANHISTNLTYRDVLLNIHKQREEEVAKMRQMGLEAPKLKFAVKPVVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2T0</accession>
    <name>A8Q2T0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2231</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730435.1">
        <property type="nucleotide sequence ID" value="XM_001730383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2T0"/>
    <dbReference type="STRING" id="425265.A8Q2T0"/>
    <dbReference type="GeneID" id="5854742"/>
    <dbReference type="KEGG" id="mgl:MGL_2231"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2231"/>
    <dbReference type="InParanoid" id="A8Q2T0"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="11">
        <location>
            <begin position="387"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="578"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="697" mass="75974" checksum="F92D0B6FF661042E" modified="2008-01-15" version="1">MLMPTPHTYLAMPESSPHAMDISSPAAMVESSDTQSFSIPYPSMMQHSQSLQRQQQQQGIPTLAPILSAAPSSSLRRADRSMRKSMPVLGQFGSMLTYSSSPESPEQKQRPKKRLASTRQLQDASFETDGPDRCVFFSEETITQSQPMNRARTHTRTQSESMWWTTTATDIQVPETRPVSPTRTVSAIGDHSCTADSSGSDSFLVPTQLNQPEAKSTSPMASYFFDPQSPHVSTIISAVPSSPMSSPSLGAVDQVPWNHRASAPLVPPSSSRQDFEADLHGLDDSCDETALIQQGGGSPVRSSVRRSTLAVPRRIKTMTETLGAKENVPPGPLSSSSTSLSTHSIPGFGSHEMDHKILPCFPVKCDGLMRVTPQTVSELMQGHYDDRISGFQIVDCRFAYEHEGGHIAGAVNLNTIEQIHRHFLTPGQGLHAGRILPTRTQSGQPDEHGDMRKFVLIFHCEFSYKRSPSMALALRQADRSLFNDYPRCYFPDVYILQGGYADFFQYRPDLCEPRAYIGMDDPRYLQARSSELSGFRRQFSRNRSFAYGDAPTFGRTTSASATAMAQMRRAPTLVPTNFVPLMPASTNAHKQDAPAGRAKRSGSATSASQPAAFTVTKSATTATAASSLAPPMHESVARDTSYSSGDSSFEASASDSPCAVAGWSRPVLGEVPQSRSSLANRLLKRADTINTISTLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q322</accession>
    <name>A8Q322_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_2294</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730498.1">
        <property type="nucleotide sequence ID" value="XM_001730446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q322"/>
    <dbReference type="FunCoup" id="A8Q322">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q322"/>
    <dbReference type="GeneID" id="5854805"/>
    <dbReference type="KEGG" id="mgl:MGL_2294"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2294"/>
    <dbReference type="InParanoid" id="A8Q322"/>
    <dbReference type="OMA" id="PHHKANA"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="259"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="355"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="544"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP43284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="668" mass="73126" checksum="2633538D6E22154B" modified="2008-01-15" version="1">MLATASSSMPVKTALDVSPDDSDLVDISLTQVQDTKVPGISATADALSPIPSSTPAVRDAALKKLPKLVHGLIPVSNRFWFAVFPKLVDADQLNVGDGLAMAHIPEDIPTSARPRKLEWFCIDEDLIYLSFSNDWGPLNVAMFYRFCVHVHQVLMSPGMEDTHLVLYTSMHPHHKANAALLCALYAMTIDHISPADAFHPYSEMEFKPFRDAGYGRADYSLTIQDILYGVRRALDHELLDLTTFDLESYEFYEQVQNGDWNWITPHFLAFASPKDRAYMATLASQGPYAAECTAKRMPVNPSLQRTVEYFQQHNISLVVRLNNALYHRGVFEDAGIEHKDLYFDDGSNPSDDILRTFIQDADRTIQAGGVIAVHCKAGLGRTGVLIGAYLIWRYGFTASEVIGYMRLMRPGCVVGPQQHFMYENASKWVRWGVEDRLRAELARQISTAAVPSDIPQTPATSRIVDMPATAPVHHIHKPTPCVGQPRKSPSPKRRRLGIVEESVSTRAQVTADDADAKLVAAELGVAPCTDAEVLGVIDANEASSPATRASKLVSTTRTSNPAPTASTTNANPLPTPKSPSPIVTTTDSGAMRATKPASPVGLRERRTMTPAQQPKAGVRTVRSPAAKPVVTRMQTRPARPGAENRPPTAIRTRPAATATAATRQPRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3C5</accession>
    <name>A8Q3C5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730564.1">
        <property type="nucleotide sequence ID" value="XM_001730512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3C5"/>
    <dbReference type="STRING" id="425265.A8Q3C5"/>
    <dbReference type="GeneID" id="5854871"/>
    <dbReference type="KEGG" id="mgl:MGL_2360"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2360"/>
    <dbReference type="InParanoid" id="A8Q3C5"/>
    <dbReference type="OMA" id="HAYVCEL"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="529" mass="58031" checksum="38B7019C4050694D" modified="2008-01-15" version="1">MPPDPTVDMNVLGAESDIIKPSKEWVLPARGKPGRKPSDSVPPTKRKAQNRASQRAFRERRHAYVCELEQKVAQYQAREIDANVQMQRIALQCREEANALRKSNEELRARYEQMEQQFLAYRRCAEAQATTHSTGCQPPLHEKTHTHCSSRDAISIRGTPTSGTTGPSKFSAVGTEGTEVNVAGSHAQDHKHFYGLRSANSTFSPPSSPTLSTSSEVKTAEAIPSTSYTPTRAVPLRRKHEPSLPLASLSEGEDLLLDLDCGFCKDATVCVCRGKARLELDEAKPSVTGAGSDSGSAPKPTLWYTKAPEPSSSNAMRLPIRPHHSSRPRLWAVTPGNMSQFGAATCSASSSQLAPQCTGDRRTCSACQTDPTLAEFCTAISRNVHLPVSTQRETKTLCESVPHAFTRLRSHPNFPSWRGGLEMLAEIVARDPVSLAFDTAQPPTPPHQQSQSTSTSTSIRTNVDPNIHRYTQCNRHKPTMLVRSKAVSEALDILDHQPDNQRVCPCPWAQLPSRLPWPRTPQAKASDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3P1</accession>
    <name>A8Q3P1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phytase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2461</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730665.1">
        <property type="nucleotide sequence ID" value="XM_001730613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3P1"/>
    <dbReference type="FunCoup" id="A8Q3P1">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3P1"/>
    <dbReference type="GeneID" id="5854972"/>
    <dbReference type="KEGG" id="mgl:MGL_2461"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2461"/>
    <dbReference type="InParanoid" id="A8Q3P1"/>
    <dbReference type="OMA" id="MGPLTPY"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="87"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="232"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="462"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="54846" checksum="791262B85C8F3D9D" modified="2008-01-15" version="1">MKPNAFPTYIGYPGSYSSGAPAAFANDMKPAASPTRGVEPIQTALAHFDKFNPFRHMGPLSPYYSAQHGNVDNARFLATPVSANGTCTLSQVHILHRHGSRYPTGGSQASLVANMLASKPKGEKAPLSFTGPLAFLNTYQYQLGEELLVPLGREQLHMSGIKAAIDYGRLAEKDLAENKRLFVRTGSQQRIVDSALAWSTGFWGNSWVNKTDFEVQIEEPGFNTTLAPNFACSAAADSFKIQEWIESYLGKATARLQQYVHGAEITPMIVYGMQQLCSYDTVAFGRSDFCSLFTEEEWLGFEFTWDKRFFFDYGPGNQVGPAMGLGWLNEFVSRLTRTPWNSTTQTSENATFNAHADLFPVDRAIYADFTHDSVLTSVLAALRLAEFSIPPKLDDKHRAFRTSQVVPFGARMVFEVFDCPTPVPPPSALEHRRIPLKAYPPEQYLRMKLNDAIVPLSGLSQCEDRKDGLCTLSGFLDSHADRNNQGWWDRCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q413</accession>
    <name>A8Q413_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730105.1">
        <property type="nucleotide sequence ID" value="XM_001730053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q413"/>
    <dbReference type="STRING" id="425265.A8Q413"/>
    <dbReference type="GeneID" id="5854412"/>
    <dbReference type="KEGG" id="mgl:MGL_2487"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2487"/>
    <dbReference type="InParanoid" id="A8Q413"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="104" mass="11883" checksum="3E835508FB30AF86" modified="2008-01-15" version="1">MVEGKPHGGAVDLWAMGVLTYEFLEGVPPFEELSGASMTYKRIAAVDLHMPERFSEEAKDLVRSLLRYNPADRLPLSKVLRHPWISRHDPTAYARASRYVRMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4I5</accession>
    <name>A8Q4I5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730164.1">
        <property type="nucleotide sequence ID" value="XM_001730112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4I5"/>
    <dbReference type="FunCoup" id="A8Q4I5">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4I5"/>
    <dbReference type="GeneID" id="5854471"/>
    <dbReference type="KEGG" id="mgl:MGL_2546"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2546"/>
    <dbReference type="InParanoid" id="A8Q4I5"/>
    <dbReference type="OMA" id="TPYEFQL"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="179"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="497" mass="54943" checksum="0B7AB18D86EB0CA2" modified="2008-01-15" version="1">MGSSEQDNYTFTVGKLDAGIVSPMFLTQAILIGDHASLIEFPSVLLPRGVGLGSVVDIRVTRNETQEQRKREEFITLQDEILQKYGVKSPSPNADLLSLDVLRNGERIAKIPRARSSTSTKLSGLAMDTEYSIQLVMSTSAGLFASNELLIKTHTLDDLSGIFVCLGCIPDARLCEATKKVVEALGARWSNQIQLETTHLVCSVSPGPTEEQQMKLYEKAEQLTLPIIQPHWLFACSDKKRMLSISPFYVDCMPPNALEVQEQISRMQEQSENTQRPVSDTADTADVRPHASVEESTNNGQVNAGLPVIPASDREVLDVHEKSAPAMLNDDTIDVWASTEPAKQRSPRNASIAAENPQSDALMAQNVWDETSTQNEHERAPVDEMRPEPTMLETDEAKMQESEAKKQSNQTPASTREGPEEELVNDKAYPVDSGLHQFVEQESESKKPTPDDESAVKGNQPVTEETQTQHTDKEALTDNTPERKTEADMENIDLNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4J1</accession>
    <name>A8Q4J1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Creatinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730166.1">
        <property type="nucleotide sequence ID" value="XM_001730114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4J1"/>
    <dbReference type="STRING" id="425265.A8Q4J1"/>
    <dbReference type="GeneID" id="5854473"/>
    <dbReference type="KEGG" id="mgl:MGL_2548"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2548"/>
    <dbReference type="InParanoid" id="A8Q4J1"/>
    <dbReference type="OMA" id="LTHFRYT"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF17">
        <property type="entry name" value="AMINOPEPTIDASE P, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="4">
        <location>
            <begin position="340"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61623" checksum="5147934AD6E6F22C" modified="2008-01-15" version="1">MGCVASRPKVTIDEKRALLAEYASNAVHFECVDTTERLNALREAMKACCLDAYIVGTEDAHASEYTANCDRRLAYISGFTGSTATVVVLMDSAHFFTDGRYHVQAAHQLGDAWTLHKVGERDVPNWREWLHTLREGSYVGLDARLISYKDAVEIKKSLAAHSITLTFPEINLIDDIWGSERPLQVLYPVQEYKLQFAGVHASDKIARLRTWLLEKGDAAYVISALDEVAWFLNLRGASIPCNPVFPAYVIVTAQEVALFVNPRLIMQHIRTYLAKLGVTVYDYEAVWKWLRDTSVGHVFVDSKASYALVTAAGERNTTVQSPASPVAMAKARKNVVEILCMTRAYKRDGAAWVKWAAWLESEMNNGAEVSERDAAQAFERIRAKDPFFAGMQAYDAISASGPNAALPHYETPTENSRIIDRMTPYLNDSGPQYYDGTIDTTRTVHFGTPTDEQKRAYTRVLQGHIALAMAKFPLGTTGAQLDMLARQPLYQDGYNYLHGTGHGIGAFLNVHEGPHGFSSSSGGASEPVALQPGMILSNEVRMDSQALGPCMNMYSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4L1</accession>
    <name>A8Q4L1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730180.1">
        <property type="nucleotide sequence ID" value="XM_001730128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4L1"/>
    <dbReference type="STRING" id="425265.A8Q4L1"/>
    <dbReference type="GeneID" id="5854487"/>
    <dbReference type="KEGG" id="mgl:MGL_2562"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2562"/>
    <dbReference type="InParanoid" id="A8Q4L1"/>
    <dbReference type="OMA" id="DANDAWI"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="50"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="340" mass="37268" checksum="50D4B79A26DD77AC" modified="2008-01-15" version="1">MAPDANDAWIDAFLDSSTEVEETRAAVSSSARAAARSLGEPGVRRRAQDLVRLAVFTEYDRMPIKRDIIIKNVIGKEASRAFPVILACAQQILRLTFGFELVEMRAKGTENPLLAEQTSLLDERAGSKRRRTDNDNTQSRKTSAASHGYVLRSTLPAEVIQFMTTSGPPVPPSDQSSRDAPHARNDLPMLDWQASEGELGITGLLFVVLGLILVSGRQASDTRIRSCLAQLSLSIDRPLPKALHPLGSGTHEQGSHTLDTFLQQAQRRGYLERVRVASAAETSSQACDWEWRWGARAEIEIGEHAVAAFMVDVYHQDAKPESSDSLTKRIERAAGTPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4N7</accession>
    <name>A8Q4N7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730206.1">
        <property type="nucleotide sequence ID" value="XM_001730154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4N7"/>
    <dbReference type="FunCoup" id="A8Q4N7">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4N7"/>
    <dbReference type="GeneID" id="5854511"/>
    <dbReference type="KEGG" id="mgl:MGL_2588"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2588"/>
    <dbReference type="InParanoid" id="A8Q4N7"/>
    <dbReference type="OMA" id="TFIVHRE"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="23"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="516" mass="57075" checksum="FAB0D295BE29585F" modified="2008-01-15" version="1">MHVRALHSSRMCCKAATIAFDELETRSFSIIAHIDHGKSTLADRLLELTNTIPSDSSNKQVLDKLKVERERGITVKSQAVSMLYQPAGQRQPLLLNLIDTPGHVDFAYEVRRSLSVCQSALLVIDATQGVQAQTISVYKIAQQCGLTIIPVLNKVDLPASDPERCFSQLQDILSLDTSVHKPLLVSAKTGKGVDQVLQALVERTEPLGGAQNMSSENRQPRGLRALIFDSWYDQYRGVIALVSVMDGAIRKGDSVVAFHSGKRYDVLDLGINNPEPVSVPILRKGQVGWLITTMKETEEASIGDTFYRAGERVQPLPGFRPALPTVFAGIFPTDKSEFLKLEDAIQRLCINDRSITLQKETMSALGQGYRLGFLGTLHLDVFRQRLEDEYGHEILVTTPTVPFRITYNDETQVLCSNPADFPDEATKKTHVACLEEPTVIGSLVCPEEYTGAMMDLCAEHRGEQLDIEFSTAGLSQVYMQYRLPLAEIVTDVRPKANRILTCSNMTNAPSPPTAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4P2</accession>
    <name>A8Q4P2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730211.1">
        <property type="nucleotide sequence ID" value="XM_001730159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4P2"/>
    <dbReference type="FunCoup" id="A8Q4P2">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4P2"/>
    <dbReference type="GeneID" id="5854516"/>
    <dbReference type="KEGG" id="mgl:MGL_2593"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2593"/>
    <dbReference type="InParanoid" id="A8Q4P2"/>
    <dbReference type="OMA" id="PCVLTCL"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="438" mass="48159" checksum="496331128AB914D0" modified="2008-01-15" version="1">MFHYLGAQHRANLAQYKYASGGSSIVSTYVLGPYWNWLVTLVPLSVAPNTLTLCGLLLVVANLGTMMYLDGDMELATRVRMNVMQNDGAVPKVPILPNGGMPERLLQQGLEPSTTSGVPSWMLLVWAICLFMYQSFDAIDGKQARRTGMSGPLGELFDHGCDALNTTLEVILASTACGYGRSYWTLVSMVSSLASFFLTTWEEYHTHVLFLSQFSGPVEGILLLCVLYTAMALGGPMIVVRGLLDLFHVAENDWVRTHLAWANFPLGDVLMSLASLGLSVNAWQAYQNVRVQCEREQRSALMPLVGLMPFVVQVCAHIAWALGNDARIMVEGSLFVPFLLSWGLSFAYLVGLVILAHVCKRAYPYWNALLVPSIVLAVDAHLPQPILQTSVAATQQLVYGVVGICAVLYAYFVYDVILTITQVTGKPCFRVPEKPHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Q0</accession>
    <name>A8Q4Q0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730219.1">
        <property type="nucleotide sequence ID" value="XM_001730167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Q0"/>
    <dbReference type="FunCoup" id="A8Q4Q0">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4Q0"/>
    <dbReference type="GeneID" id="5854524"/>
    <dbReference type="KEGG" id="mgl:MGL_2601"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2601"/>
    <dbReference type="InParanoid" id="A8Q4Q0"/>
    <dbReference type="OMA" id="LERINMH"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="57"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="320" mass="35213" checksum="7023AF04C7968591" modified="2008-01-15" version="1">MYPGLLPDLASRGIHTVNIATDEEGLSDSALASVLENWTSHEQTSKMRFPKAIYTVPTGSNPAGTTASADRKRKILALARRHQVLIMEDDPYYYIGFDGLGEDPVTRERIPSYFALEREQADEYGYGYVLRFESFSKIMSAGMRLGYVVGPKPIVTAIVAYTATSSIHASSPIQVIVAHLLRHWGVNGFLQHVDKVASMYRERRDVFASSLEKILGSGPTPVATWTTPVSGMFFWLKLHLPPTPEAPEGDSFQVIAEKALDEGVLVVPGSSFYAGGCKTPYARVSFSVIPENDIAEGLHRLRRAIESAWKDAGYSTIPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4V6</accession>
    <name>A8Q4V6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730268.1">
        <property type="nucleotide sequence ID" value="XM_001730216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4V6"/>
    <dbReference type="GeneID" id="5854573"/>
    <dbReference type="KEGG" id="mgl:MGL_2650"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2650"/>
    <dbReference type="InParanoid" id="A8Q4V6"/>
    <dbReference type="OrthoDB" id="3361273at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727220" evidence="1">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="256" mass="27508" checksum="DB7F943A5466E327" modified="2008-01-15" version="1">MLWLLLTIVWALANAVLGMGQHARMVKHHEKYSAQVSSDVVSSLKPTTTKKLGARSVPQSTLSPTSLFIPSLPGDESANDPTSVYYYGEGFISYTSVYALITGRPSKDGGLKTNYMYQGPTEIKIPHVMRTAVVGDKTLSGLFDVDCSVKTGKKSGWQCQYGYETSGATSSYSVVPTNTQPNTFITPIVGKLDQAQKQSADGISDVPSFSDGKVVHVHPSNRAQRLTSIFSTLPSSFTIPCVLFSAALVALCAMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4W0</accession>
    <name>A8Q4W0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730271.1">
        <property type="nucleotide sequence ID" value="XM_001730219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4W0"/>
    <dbReference type="FunCoup" id="A8Q4W0">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4W0"/>
    <dbReference type="GeneID" id="5854576"/>
    <dbReference type="KEGG" id="mgl:MGL_2653"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2653"/>
    <dbReference type="InParanoid" id="A8Q4W0"/>
    <dbReference type="OMA" id="KCINLMK"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="439"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="822" mass="94089" checksum="AB901BFE57ECE90A" modified="2008-01-15" version="1">MSSGAPRRVGARHHKLRAPRTHGLSVSVDEMWSRLSSAIAQIQHHNISKLSYEEHYRYAYNLILNQQGDMLYGGVRRQVHEHLVHQSDQRLVPLFLLSTEDAVAVTEALSSKGKRREDAAREEARVFAWLPGQADELLPSIPAGERFLGAVTDVWEDHCSCMSKIRDVLKYVDRVYVPNHHRAPIWDLGLELFRDSVVRSARVPCRANLIVAMLRQVYCEREGATVERRTMKAAADMLLSLSHDAHSSVYAQDFEPVFLATTSQYYAAEAARLLSVQQATYYLQAVERRFADERVRVEACFSPATLAPLKDLVERHLLSEQLDAILDMEDGGLVSLLDADARADIERMYRLFRLVPPGLDALNKVLRMYVTNRGKTINETTLAGQDGAPSAEVALSWVNQVLDAKNRLDGILHTSFHSDKSCEAAINEAMDAFINMNVRAPEYISLFIDEHLRKGTRAADDTTLEQMLDKTITIFRYIHEKDVFERYYKMHLTRRLLHNRSVSDDAERSMIAKLKVECGHGYVQKLQGMLNDMKLSEEVLAAFHRAQEREQRQLPLQMNVHVLTATYWPISSPTEPCTLPPALLEACESFEKFYGTRHRGRVLTWQPTLGTAEVRVRFKTRTHELVVSTYALMVLLLFEHSDTLSYRDIRAATRMPDVDLQRTLQSLACAKYKVLQKEPKGRDVHETDLFSFHADFTCPLARVKIAQIAAKVESPQERKETTAKVEEERKNQVEACIVRIMKSRKTLAHNDLVHEVVHQLLPRFQPSPALIKKRIESLLDRGSYMRLSLHEAFIRFACILTRTHTPEYIERTEARHVYQYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4X6</accession>
    <name>A8Q4X6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="3">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730284.1">
        <property type="nucleotide sequence ID" value="XM_001730232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4X6"/>
    <dbReference type="FunCoup" id="A8Q4X6">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4X6"/>
    <dbReference type="GeneID" id="5854589"/>
    <dbReference type="KEGG" id="mgl:MGL_2666"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2666"/>
    <dbReference type="InParanoid" id="A8Q4X6"/>
    <dbReference type="OMA" id="VQRDIKH"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000720">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000056">
        <property type="entry name" value="Putative Hsp70 family ATPase KAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728090" description="non-chaperonin molecular chaperone ATPase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="667" mass="72624" checksum="6D6AA46608FDDED9" modified="2008-01-15" version="1">MTMMSVLFGLLSLLSLSLLLSSTPYAGSAVAAQDKRSEYGTVIGIDLGTTYSCVGVQRQGRVEIIANDQGNRITPSYVAFSKDDERLIGDAAKNQAAQNPENTIFDAKRLIGRKWGEADIKKDIKHLPFKLVEKKGKPAIQVTVHGKEKVFTPEEISAMVLQKMKDTAESYLGHKVTHAVVTVPAYFNDAQRTATKDAGTIAGLEVLRIVNEPTAAAIAYGLDKKEGESQIIVYDLGGGTFDVSLLSIDSGVFEVLATAGDTHLGGEDFDNRVSEYLLKQFKKKEDLDASKNKRSVGKLRREVERAKRTLSSQMSTKIEIESFFEGKDLSETLTRAKFEELNADLFRRTLKPVEQVLKDAGVKKDEVDDVVLVGGSTRIPKVQQMLKEFFNGKEPSKGINPDEAVAWGAAVQGGVLSGDESLGGVVLIDVNPLTLGIETTGGVMTKLIPRNTVVPTKKSQIFSTAADNQNTVLIQVFEGERSMTKDNNLLGKFELNNIPPAPRGVPQIEVTFEVDANGIMKVSAADKGTGRSESITITNDKGRLSKEEIDRMVAEAEEFAEQDEAIRKRVEAVNNFQNFISMLRTQITDKEGLGGKLESSDKTTIQQHIKDAEKWMEENGESAEAQDIEEQLSELQAAVSPITAKVYGAGGGSGAGSDEPLNYHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5J9</accession>
    <name>A8Q5J9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729801.1">
        <property type="nucleotide sequence ID" value="XM_001729749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5J9"/>
    <dbReference type="STRING" id="425265.A8Q5J9"/>
    <dbReference type="GeneID" id="5854102"/>
    <dbReference type="KEGG" id="mgl:MGL_2787"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2787"/>
    <dbReference type="InParanoid" id="A8Q5J9"/>
    <dbReference type="OMA" id="VENMMGG"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000010">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.5, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="2">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="114" mass="12444" checksum="79015D1A7972C16A" modified="2008-01-15" version="1">MCNPKLGLETNIQKLRSIAEKECDPKLGLRVIVEPGGCHGYVYKMELTSEYESDDFVFVESNARIIVDSITLSLIKGSTVDYVTELIGSQFAIVENPQAKGSGCGCGVSWEPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q657</accession>
    <name>A8Q657_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729869.1">
        <property type="nucleotide sequence ID" value="XM_001729817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q657"/>
    <dbReference type="SMR" id="A8Q657"/>
    <dbReference type="FunCoup" id="A8Q657">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q657"/>
    <dbReference type="GeneID" id="5854176"/>
    <dbReference type="KEGG" id="mgl:MGL_2855"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2855"/>
    <dbReference type="InParanoid" id="A8Q657"/>
    <dbReference type="OMA" id="XRISAMI"/>
    <dbReference type="OrthoDB" id="2532770at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="11">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="134" mass="14758" checksum="CB7AFEB9861216E1" modified="2008-01-15" version="1">MCGTPLDLTTFSSLHLFPSNNHVWTYVCANVLTAGGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYDETRGVLKLFLESVIRDSVTYTEHAKRKTVTSLDVIYALKRQGRTLYGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6G4</accession>
    <name>A8Q6G4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729973.1">
        <property type="nucleotide sequence ID" value="XM_001729921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6G4"/>
    <dbReference type="STRING" id="425265.A8Q6G4"/>
    <dbReference type="GeneID" id="5854280"/>
    <dbReference type="KEGG" id="mgl:MGL_2959"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2959"/>
    <dbReference type="InParanoid" id="A8Q6G4"/>
    <dbReference type="OMA" id="DRNSHAN"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF2">
        <property type="entry name" value="FE-REGULATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="102"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="485" mass="53672" checksum="2561F237F47722F8" modified="2008-01-15" version="1">MEAAIMRDSENLVEKEQLDHSKCCILQVSDLISNQLHVDKDHARQPVEPLHKNNQHFEDDPYAYAHPHMIVHGSVQAIRDTYVTVKQHNSESADCAKQPSKKPLWSLDTINIPYTHLIYALGSHMPDPLRRDSVSKQHGVEWMQRNQQRIRESHDVVIIGGGALGVEMACDIASLYKQKGEPKNVTLIHSRKQLLPIFDPRIHEVAYKHLKDLGVNVVLGHRLATAEGCPLGSTVRKVATTDPSNVSKDAMEAVAGSSRQRIRTTLGLELECDLLLMCTGQQPNSEIMAEFSPASVNPSTRLVRVLPSLQVMISEDEEATSQPFSVVPPCVDCDCFLDRKAEGASRTFDENGVIPPHFQNIYAIGDVADAFGALNAGFQAWFMADIAAENILRDILHVKSTTDPENNKLDDSEPVPLTSFKPGPPLLKLALGLHKLVTQGAPEPDESLPGKPIRPTIAVKEDSEDMDIELTWKYMALADPSNMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6I7</accession>
    <name>A8Q6I7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729992.1">
        <property type="nucleotide sequence ID" value="XM_001729940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6I7"/>
    <dbReference type="GeneID" id="5854299"/>
    <dbReference type="KEGG" id="mgl:MGL_2978"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2978"/>
    <dbReference type="InParanoid" id="A8Q6I7"/>
    <dbReference type="OMA" id="FESHHEV"/>
    <dbReference type="OrthoDB" id="3361805at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725487" evidence="2">
        <location>
            <begin position="27"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="421" mass="46753" checksum="4F614241520A887F" modified="2008-01-15" version="1">MKSSIAFISSCAFLFILAVLIALVLQCTNPPRLEARHPSLPPVGVRKRDDQVNAVQYPAPAPTTETSQLPTNPLNRAQPAASMSSQTLSMDPFENDTTKQPFVQSSYGQLPQPTVDATAPILQPVAETGRYKKTRSRALPQPPVPSRSDHGSHQGYYANGTSAYNNASATGYSDVGNVYNQQGYGYGYGYGYGTGTGASTGYTHVPNYAYPYEGMYQDASSPFNAYEVSAPVRGQASYQSHGYVPLPVPSASQPYGNYQDPNTFNSVSPSQHWSSKYNDYSHHRPLARHASQASSGKNSHLSRVDSVGAGDYRRHSQRRRNRKSEADTTLEKSQPRKSFADTTGNKQAPTPYSYDPGFSVAPNETFAVNYSFNEDSHYPLRDEYKYSQPELLWNSDYTNKGHYNSYYDAYPNKYQHRYDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6J0</accession>
    <name>A8Q6J0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729995.1">
        <property type="nucleotide sequence ID" value="XM_001729943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6J0"/>
    <dbReference type="STRING" id="425265.A8Q6J0"/>
    <dbReference type="GeneID" id="5854302"/>
    <dbReference type="KEGG" id="mgl:MGL_2981"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2981"/>
    <dbReference type="InParanoid" id="A8Q6J0"/>
    <dbReference type="OMA" id="WTIDMKK"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF28">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="122" mass="13313" checksum="0F8B579DA39184E3" modified="2008-01-15" version="1">MSDFKSAQLFKQIQEGISGFSDAQKKDLQKKTNAVFEFHVKNAAGKELVQTIDLKKDVAVYEGKAKGKADCVINVSDDTFSDLGEGKLNGQKAFMSGKLKVKGNIMLATKLDNVLKAQRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6J7</accession>
    <name>A8Q6J7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LSM1</name>
        <name evidence="8" type="ORF">MGL_2987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730001.1">
        <property type="nucleotide sequence ID" value="XM_001729949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6J7"/>
    <dbReference type="FunCoup" id="A8Q6J7">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6J7"/>
    <dbReference type="GeneID" id="5854308"/>
    <dbReference type="KEGG" id="mgl:MGL_2987"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2987"/>
    <dbReference type="InParanoid" id="A8Q6J7"/>
    <dbReference type="OMA" id="VFVGNRY"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="147" mass="16263" checksum="DB0A9AEFDE7F2F7B" modified="2008-01-15" version="1">MEAQEILANIAFTTSGALVDLVDKRVIVVLRDGRKLLGVLRSYDQFANLVLQDAVERIFLGHRYGDVPKGTFIVRGENVVLMGEIDLEKEENIPASIASSIPSTAVPQLLETLAAENEYKAKWEQRRAAVLRRERGFSGEGAEGDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6Q0</accession>
    <name>A8Q6Q0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3029</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730043.1">
        <property type="nucleotide sequence ID" value="XM_001729991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6Q0"/>
    <dbReference type="FunCoup" id="A8Q6Q0">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6Q0"/>
    <dbReference type="GeneID" id="5854350"/>
    <dbReference type="KEGG" id="mgl:MGL_3029"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3029"/>
    <dbReference type="InParanoid" id="A8Q6Q0"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="180" mass="20436" checksum="9DC3D9E2F343A838" modified="2008-01-15" version="1">MRPLTDAETTTLFEKLAHYIGKNLVHLIDRPDDPYVFRLHRDRVYYVSEANMRLAVSVARPNLMSLGTCFGKFSKTGKFRLHITALDYLVQYARYKVWIKPNGEMPFLYGNHVLKAHVGRITDDTPEHAGVVVLSMSGVGLGFGVTARSTSDTRNMDPTNIIVFHQADVGEYLRDEETLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6R1</accession>
    <name>A8Q6R1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730050.1">
        <property type="nucleotide sequence ID" value="XM_001729998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6R1"/>
    <dbReference type="STRING" id="425265.A8Q6R1"/>
    <dbReference type="GeneID" id="5854357"/>
    <dbReference type="KEGG" id="mgl:MGL_3036"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3036"/>
    <dbReference type="InParanoid" id="A8Q6R1"/>
    <dbReference type="OMA" id="HSHFANR"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09252">
        <property type="entry name" value="AP-3_Mu3_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="265"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="552" mass="60799" checksum="E50E0C17A04BF174" modified="2008-01-15" version="1">MLSRFRNGNTLYPMMHVSYLCEKIKDVLGRSENGAYSSLDPAAPMAVRDIPPVLSVPLADSVLESSSESDGMEDEVADDDDDDHGSEEHETSPQQGSQTLPDLPDEALAWSDGAERNYAPKAPDSNSETCIPLEGGSVLCHIMVGSLRFLCPMSHDLDPLISFAFLHKAADVLQDYLVGSKDPALLTEDLIRQHFDIVYQLMEEMLDGEGNVLLTEINALKDIVVPPRWLDKIANKVGLNSSPEHARMSLASPVPWRRTNSRYSKNEVYLDMIESIEGVIDANGCPVALDVWGKLTCSAWLSGMPELLVSLNHPSLLELPAWHQCIRQQTWEKQQKLCFVPPDGECVLSEFRIRVPSKSTSSSCTLKRPISSDSSASEFNSNSLPMKVYAYYSPYNAAHGGLPFNITVDHALDPAYDLQDVCIDWLLGDGVQGVDAITQVNTVATKTSMSSDIGSIPNLSRTAGNMVFDRKQQHLRWVIPKISPCTQSVLKGTILSTSACRPMYALDVQFSVFGYTMSGLRVSSIQIQPESYVPTKGARVCHSGRLEWRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q731</accession>
    <name>A8Q731_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MGL_3299</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729755.1">
        <property type="nucleotide sequence ID" value="XM_001729703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q731"/>
    <dbReference type="FunCoup" id="A8Q731">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q731"/>
    <dbReference type="GeneID" id="5854061"/>
    <dbReference type="KEGG" id="mgl:MGL_3299"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3299"/>
    <dbReference type="InParanoid" id="A8Q731"/>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="69"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="258"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP42541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="406" mass="45041" checksum="F73CF25EEF803659" modified="2008-01-15" version="1">MSSPLTRTTLRSATRVSSTPLRAPVRSLSVLASHATRATRVMPSSSSVRPAMPSVMRGMKTLDFAGTPEKVYEREDWPLEKLHDYFKNDTFALLGYGSQGHGQGLNLRDNGLNVIVGVRKDGESWRQAMEDGWVPGKNLFTIEEAATKGTILMNLLSDAAQTSTWPELQKYVTKGKTLYFSHGFSIVYKDQTSVVPPSDVDVILCAPKGSGRTVRTLFKEGRGINSSVAVFQDVTGQALEKAVAIGIAVGSGYIYETTFEKEVFSDLYGERGCLMGGIQGMFKAQYDVLRAHGHSPSEAFNETCEEALESLYPLVAQNGMDYMYKACSTTARRGALDWAPEFEAACKPVFERLYESVKNGSETRRALEFGSRKTYREDYDKETDAIADQEMWRVGHVVRALRPNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q748</accession>
    <name>A8Q748_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729759.1">
        <property type="nucleotide sequence ID" value="XM_001729707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q748"/>
    <dbReference type="STRING" id="425265.A8Q748"/>
    <dbReference type="GeneID" id="5854065"/>
    <dbReference type="KEGG" id="mgl:MGL_3303"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3303"/>
    <dbReference type="InParanoid" id="A8Q748"/>
    <dbReference type="OMA" id="YEYFDIQ"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="311" mass="35077" checksum="CE009A826B5F0C74" modified="2008-01-15" version="1">MSFEVCRMPDGATIGYKLLGKEHAGATLVMVTGMSAVMDDWMPLAECLAHTRRVLVFDHRGMGTSSMTAEQDEDITIELLAQDVLQLCNALHVRHVHLLGFSMGGIIAQAILTHPDARATSDQAGVSGVSVQGVEVRRVLLAATFTKSPRTKFRANQVPVPEHASWEERSLAYIRYILALQYHADVLGDGKPLQPMFDERMRVGIHHKRPQTVIGYQAAAISRYANRDQLRHVPRNLPIAVIHGRYDQMVLYEESNDILRFLPQAMRLYPNVASPDDREAFAHMWFDYFDMERAWVVPIIKFLDAPLSARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q794</accession>
    <name>A8Q794_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="9">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3315</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729771.1">
        <property type="nucleotide sequence ID" value="XM_001729719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q794"/>
    <dbReference type="FunCoup" id="A8Q794">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q794"/>
    <dbReference type="GeneID" id="5854077"/>
    <dbReference type="KEGG" id="mgl:MGL_3315"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3315"/>
    <dbReference type="InParanoid" id="A8Q794"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="104" mass="12098" checksum="0D5CE2D73B126446" modified="2008-01-15" version="1">MSQYVNVPKSDLDEGQIRELEQYEISQGPLSVLQQSVRNHSQVLISLRNNKKLLARVKAFDRHSNMVLENVKEMWTEVPFGRFKVARQRCNELHLPSNDSIGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7M3</accession>
    <name>A8Q7M3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial 20 kDa outer membrane protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import receptor subunit tom20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translocase of outer membrane 20 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_3085</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729541.1">
        <property type="nucleotide sequence ID" value="XM_001729489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7M3"/>
    <dbReference type="FunCoup" id="A8Q7M3">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7M3"/>
    <dbReference type="GeneID" id="5853847"/>
    <dbReference type="KEGG" id="mgl:MGL_3085"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3085"/>
    <dbReference type="InParanoid" id="A8Q7M3"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000002">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="122"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP42327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="210" mass="22815" checksum="65BCA893FD192002" modified="2008-01-15" version="1">MFRKKLRKQSKQSMKEAKRELKAAAQQETMMIEKAVRDAAEPGALPSGVQEKEAFFMEQVATGEALFAQGAAYHVPAAIAFFKALKVYPAPVELVMIYQKAVPKEVFDLIMKLVTRDAAVNSAGASSQSSGLDQVDDKVSNDKNNKEGGSESADQSSPEKKPEVQSQEEKLSRAENNAETSAEKPGNTQSQEAKSEQSSKANTDKEAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7U4</accession>
    <name>A8Q7U4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl-CoA thioesterase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729580.1">
        <property type="nucleotide sequence ID" value="XM_001729528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7U4"/>
    <dbReference type="STRING" id="425265.A8Q7U4"/>
    <dbReference type="GeneID" id="5853886"/>
    <dbReference type="KEGG" id="mgl:MGL_3124"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3124"/>
    <dbReference type="InParanoid" id="A8Q7U4"/>
    <dbReference type="OMA" id="FFETRYC"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF35">
        <property type="entry name" value="ACYL-COA THIOESTERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="29"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="269"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42033" checksum="2F0C7F7B56CA7E31" modified="2008-01-15" version="1">MVEASAFLRSIGVRQTEEPWVFEGVSPPLGMGNVRPIAYGGYAIATGIVAAGQTIPSTTPHFVPYSLLGHFLGPANLQHPFVCHVTSVRDTRTFATRSVLVKQLSKGGEFRNVLSITLDFIASPNSEPEKIMQLHQENIDPSCVGSLLRYDPITPWKIERPEELPKPHEYTQQRLADGYVDEFIVDLQHKILGLWSEIFDTRSVPSCMMQQNSIGMMDVPTTQDRLPLVQRRTFDWMRAREKLPTANSIECAHGTGKQKGMLPISSVIAHVATIAFALDGALSFAPLSLAKQSFLSASAASTLEFATRFHTDVLDINQYLLREIQPIHAGWQRTFSEARLFDTSGRLVASCSQQGVMRPADENAIATPQVPPPFRPAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2023-06-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7U6</accession>
    <name>A8Q7U6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729582.1">
        <property type="nucleotide sequence ID" value="XM_001729530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7U6"/>
    <dbReference type="GeneID" id="5853888"/>
    <dbReference type="KEGG" id="mgl:MGL_3126"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3126"/>
    <dbReference type="InParanoid" id="A8Q7U6"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="96" mass="11029" checksum="430327FD97287AB4" modified="2008-01-15" version="1">MRKQVQNMTGVLYTNTHIHIPSHSFIPFRSVPSLHIRHPSHKHTGVHTHTHTHTHTHTHTHSHACAHRHDNQNAYKALVVCPPFVQVVQTLLGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q836</accession>
    <name>A8Q836_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729650.1">
        <property type="nucleotide sequence ID" value="XM_001729598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q836"/>
    <dbReference type="STRING" id="425265.A8Q836"/>
    <dbReference type="GeneID" id="5853956"/>
    <dbReference type="KEGG" id="mgl:MGL_3194"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3194"/>
    <dbReference type="InParanoid" id="A8Q836"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="5">
        <location>
            <begin position="228"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="345" mass="38406" checksum="529B0E77DE1773B1" modified="2008-01-15" version="1">MSRGEPSRMPISFSFKHAGSKVSPLNARKVWIDHDMDEDVHASGKHADVPLSGKRKRDDAAASSSRTTAPQPKVIPLISSSNWHDERRRRIGISEKHGWQSEPLTPGSKRLTSLSRQPPDELATEQAFSEPSKQGLVRRAPKEGTERDSTPPAEQISSGASTPRESFSTSNEPTDHDALQALLAGEKGAVSNPLAKVIQQPNEEEMFHRDVGTRPNEPTLDDYQSMPVEEFGAAMLRGMGWKEGMGAGKRRNGPAHAPIIQRRAALLGLGAKERASPTMISGQRRDVDRHYKPVTSRDNRSRHSASYGPSRYREGENLPRREKHGSNNRSEHRYQSQYGSYHHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q894</accession>
    <name>A8Q894_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729685.1">
        <property type="nucleotide sequence ID" value="XM_001729633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q894"/>
    <dbReference type="FunCoup" id="A8Q894">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q894"/>
    <dbReference type="GeneID" id="5853991"/>
    <dbReference type="KEGG" id="mgl:MGL_3229"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3229"/>
    <dbReference type="InParanoid" id="A8Q894"/>
    <dbReference type="OMA" id="VHITFVD"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="204" mass="22473" checksum="0794875CD45A582B" modified="2008-01-15" version="1">MSGLGETRRVCRIRLPKIPLNMQANRHAMGVCLAGALFAGGWWLFFDACIRSGRLNMSTPAPLPSPVPQPRPGEPIPQPKHGVFIKFDDWVPGLCATIGLSIVNLVDKRHLMDEDGTGQIGAWQDDPVMWRTRTWLFIGFAFLAGGIAGSLAILIIKYMMNPDAVGFVEFGVAGVLQNLAIMACAMVLWFSQHVESDYEYNLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8E4</accession>
    <name>A8Q8E4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729712.1">
        <property type="nucleotide sequence ID" value="XM_001729660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8E4"/>
    <dbReference type="STRING" id="425265.A8Q8E4"/>
    <dbReference type="GeneID" id="5854018"/>
    <dbReference type="KEGG" id="mgl:MGL_3256"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3256"/>
    <dbReference type="InParanoid" id="A8Q8E4"/>
    <dbReference type="OMA" id="MSASHAH"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35130" checksum="4FDFEB2199DBD655" modified="2008-01-15" version="1">MSASHAHEQRQDRPPMELEVSSNGREGSFAQIPLPSKRQHTREPLAVPKDTLEAWHEATVSSLSLLPVACVEPNATVRTALAASRAHRGQSVLIAEQGYLRGYVDLIDLVSHETQGSLDDLVQDIQHRFVPLSDGTFRVIHAGTRLAEVAVFLESAPLALVSDEAGTHITNVVERGDLMRYAETSGMHAPGGMEQETSMPNRNDEESRRDRSLVDVLRRLDGYAPLIPDEVTDYYLERAGFQCEDVRLKRLLALATEKFVADIASDAFQYARIRTNAGPARSSRPTRDRARTVLTMDDLSAALGEYGIDARRAETFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8H9</accession>
    <name>A8Q8H9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729730.1">
        <property type="nucleotide sequence ID" value="XM_001729678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8H9"/>
    <dbReference type="STRING" id="425265.A8Q8H9"/>
    <dbReference type="GeneID" id="5854036"/>
    <dbReference type="KEGG" id="mgl:MGL_3274"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3274"/>
    <dbReference type="InParanoid" id="A8Q8H9"/>
    <dbReference type="OMA" id="GNQVRYT"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="272" mass="30271" checksum="2A91529638F7031D" modified="2008-01-15" version="1">MTTTDDTGNLKGASSSATHTAKHVWHALLGAEAGSDAQYDARIHGRKLQLANVDRAAPPPATPLLEKQYRKALRRTQRHAFPSYVPPPPRKPKTKNSKRKNQRIHHDEKLSLDQVQPLVHLWTAYIRDALHLRGMTCCSAQQQLRQASWANALQTSLLKMDWTGAHITGTPPLHGIPQLTMASVVRSSQPNLVHTSGIVVKETHETFAIVQKNLPTDVVVPPKCIPKCNTVFQLALPLDDGQLGVDLHGNQVRYTLPVRVTRKHKARKTMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q950</accession>
    <name>A8Q950_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L22e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729377.1">
        <property type="nucleotide sequence ID" value="XM_001729325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q950"/>
    <dbReference type="FunCoup" id="A8Q950">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q950"/>
    <dbReference type="GeneID" id="5853684"/>
    <dbReference type="KEGG" id="mgl:MGL_3412"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3412"/>
    <dbReference type="InParanoid" id="A8Q950"/>
    <dbReference type="OMA" id="YQLRFYN"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14902" checksum="3F8E14D5ACD641D2" modified="2008-01-15" version="1">MAVTKTNKVVGAGASKASAKGNSFFIDFSGPANDKVLDGDAFEKFLHDRIKVDGKAGQLGDVVQISREGEGKIWVKTTIPFSKRYLKYLTKKFLKRAELRDWLRVVATSKAGFEVKFFNVSYDQEEEEEGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q963</accession>
    <name>A8Q963_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">MGL_3420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729385.1">
        <property type="nucleotide sequence ID" value="XM_001729333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q963"/>
    <dbReference type="FunCoup" id="A8Q963">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q963"/>
    <dbReference type="GeneID" id="5853692"/>
    <dbReference type="KEGG" id="mgl:MGL_3420"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3420"/>
    <dbReference type="InParanoid" id="A8Q963"/>
    <dbReference type="OMA" id="VAMWDFQ"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="138"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="306" mass="34196" checksum="C36824D4DD09856C" modified="2008-01-15" version="1">MVRARGRGRGRGRGQVREWEPEDGADCLGSSVWNDKDTSGSPRAYLKSDSEDEDVDDEEYEGGHADAEDEEDTDQEDADDDDDEEEEDELGSASDLATPVPVAMWDFQHCDPRRCSGKKLARHGLIKELRVGQKFRGIVLTPHATQVLSPSDTPILREFGVAVVECSWARLDEVPFGKIKSPHERLLPRLMATNPVNYGKPFKLNCVEAIAAAFYVCHARPLGDQLLSKFAWGCNFPALNHAYLARYRACRSSQEIAQAADQFAMEEEQERIERQLAKTELGGYGSIPLPPVEDSEDEVKLDNRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9N6</accession>
    <name>A8Q9N6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3519</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729484.1">
        <property type="nucleotide sequence ID" value="XM_001729432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9N6"/>
    <dbReference type="FunCoup" id="A8Q9N6">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9N6"/>
    <dbReference type="GeneID" id="5853791"/>
    <dbReference type="KEGG" id="mgl:MGL_3519"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3519"/>
    <dbReference type="InParanoid" id="A8Q9N6"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="70"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="355" mass="38650" checksum="4871974F4CFDD3B4" modified="2008-01-15" version="1">MTTPSKRTFHIKVPCTSANIGPGFDVVGLSLSLYLHMDVMIDATQTDQKEPILSYSGHGADDAPLNPYKNLITRVALYVMRVNDIKSFPTGVQIHVRNDIPFGRGLGSSGAAVIAGLLLGNELGELNISRDRLLDYALMIERHPDNVAAALIGGFIGSYLLELTGEAAATTQVPLSEVLPEYPENASESWGYDPPVPPQGIGHYIRFGWAKEIKVIVIVPHFEVLTAEARRVLPDMYSKKDLVFNLQRLAVLTTSLARSPPDVNLIFQAMQDRVHQPYRKHLIPGLPRILASVTPTTHPGLLGICLSGAGPTILALATDNLQHIADTICGEFAKENITCDTKFLEVTEEGAAVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9T1</accession>
    <name>A8Q9T1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729521.1">
        <property type="nucleotide sequence ID" value="XM_001729469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9T1"/>
    <dbReference type="STRING" id="425265.A8Q9T1"/>
    <dbReference type="GeneID" id="5853828"/>
    <dbReference type="KEGG" id="mgl:MGL_3556"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3556"/>
    <dbReference type="InParanoid" id="A8Q9T1"/>
    <dbReference type="OrthoDB" id="3134107at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="70" mass="7525" checksum="734EC40F8376C064" modified="2008-01-15" version="1">MSAHNLAIVFGPTLLRSPHEAQMAGAGAAASHGGVGQMYFPDMSLQCKAIETILLKYRDIFVESDEDDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA56</accession>
    <name>A8QA56_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729148.1">
        <property type="nucleotide sequence ID" value="XM_001729096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA56"/>
    <dbReference type="FunCoup" id="A8QA56">
        <property type="interactions" value="533"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA56"/>
    <dbReference type="GeneID" id="5853454"/>
    <dbReference type="KEGG" id="mgl:MGL_3615"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3615"/>
    <dbReference type="InParanoid" id="A8QA56"/>
    <dbReference type="OMA" id="DKATHPR"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="210" mass="24252" checksum="B5B864013B2A470C" modified="2008-01-15" version="1">MESPQKPPGPPPRPPPSLRQRTQSQEARMPKPIDESQLSPKERYVLSQRREVDRVLLRAFRMNPYDVLDLTQDADDKSIQKAYRKKSLLIHPDKMADDQARAEEAFDLLKKSLDHLLDADRRKLLDETVVSARCLALRELGLPMTLTPEEIELEKVPGGRLDQLAPSFDDRIKIFVKDIVLDEELKKRKKDVDEWRLHDTLQSSPAEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA70</accession>
    <name>A8QA70_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729162.1">
        <property type="nucleotide sequence ID" value="XM_001729110.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA70"/>
    <dbReference type="GeneID" id="5853468"/>
    <dbReference type="KEGG" id="mgl:MGL_3629"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3629"/>
    <dbReference type="InParanoid" id="A8QA70"/>
    <dbReference type="OMA" id="IKCICSF"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="389"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="806"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="899"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="906"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="938"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="965"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1081"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1100"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1116"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1135"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1151"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1164"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1218"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1256"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1286"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1306"/>
            <end position="1326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1333" mass="144310" checksum="A14C335D7CB79CA2" modified="2008-01-15" version="1">MITAPESQVQDESLHGAPSTFVQGQDVEGKSFPTLPVAPVMGSFVRSEEGFVAPSTTAGRAEMNSNTNLEYHNHEEGENTHDQGTDEEAGVIRCICLCDDDDGFTIQCDRCLVWQHCACLGMSHSSVPDEYLCEKCDPRPVNVDYARAVQRRRLQQEAQKSFKARDFDISSTFATNAAAAGMMESAANAATESSLHGTKTSAPRRKSQHSRSPTTRPIPDRDVPDDMDLNTPHVTRSRPRNKRSRSGSRKSLPTPSRHKGSDDENAHTKLESWQVEFSPTDVNQVRESTTMRLLAQFMLDWHRGTPLTAAQDDEGFFIAPLRFMQDSQEEASSLDDSSPDLCSPNGLAAVGNELVPVAVHCSSLSEAGVSLSVRSISDHTTNNFFNNIMHVQPRSSEPQKIWSASKMFCRPSMHGLFADTSIPPGAFIMEYRGELYGADTYRANRINQYDKIGTTKPHVQMLPHPLNMVIDARMYGNIARFARSSCHPNAVLRPIFQYSGESDMPKLAFGLFAIAPIPKSHEVTLGWNWDDNHIVHVLPALVRHSSQSADDVSHLKGYSVSTNIAAERGEFPYVSSILANKCNAVVSILLSYATCACLGPSLGGSNTNAYLVRRQNCAVTQMLRLSQGMPLLYTTQSPRIPAKAKPIILNPLVGVFRQWLPPVCMDEDSQLCTKIAQNSCYVQRVSAMPHQSNPSVAPKSHAPPHRDEIEDKMSVDDDDVTSDAGSEGQVSLASTDIVTEEMPFESDPEDPLVSKALTCMVEEAKALLPLKKRGNHHRFGSISFQAHEHKSLAHTGMHRHVLPQNSPTKVAAHSAKESTSNEVKPKHSRGESSGHKDDMTFFDRNRPDVLLPTHHIHHDPSQVCMLQDNEDHIQSHQQPSPKAEDQAPTITIPSSWEHSAIRTPSGLPPQSPLPPLQPPPRRNGTAALESGHTAQQTSSHLSDSRMSSDAPSSSSMVSSGELPFASSSNEAVQDASNDATMPTPPAPPKRLSLAEYKKRLSSRRKSENQSQGETADPVASVTMPPSSNPSSSIESRGSTSHKSSLQSPPISFSSTADSPAATREAGEVSHVPEATPVAAPSSSQVFLSSSSQSDRHASVPNHQSSWTRSLQQLGKDASHSEQHHASLGEPGAAAMRHEPSSVRAKSDMSHDSLSVTHPQQFTTSPLLPASPPSSGSVSVRMSESIHGPACAPGSPPLPAATRPSAQGAMSFSKYLARPTSNSNALSPPAPSFSPHLSLAPPPSQSLHRVSTGPMRLSPPPPPGPPPPMPAKLRAAQNRVDVRSKQVHSLQVTNRSPGPPQLKAPTGSLTPHGSLASQRGRSTTHGRSSWRPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA90</accession>
    <name>A8QA90_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_3649</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729182.1">
        <property type="nucleotide sequence ID" value="XM_001729130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA90"/>
    <dbReference type="FunCoup" id="A8QA90">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA90"/>
    <dbReference type="GeneID" id="5853488"/>
    <dbReference type="KEGG" id="mgl:MGL_3649"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3649"/>
    <dbReference type="InParanoid" id="A8QA90"/>
    <dbReference type="OMA" id="NGVCIRN"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="40"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="284"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="584"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP41968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="925" mass="103667" checksum="AB44525308D4FFD5" modified="2008-01-15" version="1">MFFLQPIYQYFNPQSAPRFSSMSVPQNESKWFRLPTDVRPIHYDLTLFSDLEQLQFQGVADIALDVGRDTQTLSFNIGKGLDLSHVLVSYNHQQHVLIPSIDMPHERVTVSLPEPVTKGTNLSLVVGYRGAIDQSMMGYYQSTWHHEGRTGNYALTQFEPTSARRAFPCWDEPELKATYSFRMLHRESTTALANMPSVQTKAVEKDAVAKLLRVDELKLEAPDLGNDAWVLTEFAKTPKVSSYLVAWANGVFEHIDGSFTSPLTGKKVPMRVYTTPEYIHQAQYALEVKQKVLPEYEKVFDIAYPLPKLDTLVASDFDAGAMENWGLITGRTSVFLYDEKSGLQGMKTTAAVQSHEVAHMWFGDIATMAWWDNLWLNEAFATLMGEVIILDRVFPEWKSASEFIVSHLNRALDLDGKRSSHPIEIPLQGENVEDAVNQVFDAISYSKGASVLRMLSKMLGEDVFLKGVSLYLKKHLYGNTVTSDLWDGISQASGRDVNAIMSNWVLKQGFPVLTVSEGSNSIRVRQNRFLATGDPTPEEDETLWQGPLALKVVKDSKPTTDYDAMLNGEREKEIPLPDARNSVWKLNAETIGVYRVAYSPEHLAKLGKAAAQKDSAFSLEDRVGLVSDAFTLAQAGYSKTSGGLALMHALRGDDSSLVNTAAALNLAKLASVWWEQPEPVREGINKFRADVFGPMARELTFEFGGNDSSELRELRETVISAAASAGDEWTISEIRRRFAPLQEKGDYSLIHPDLLRTVLAQAIKHGGEKEYETVLSIYRSPPTPAHKTSAMIALGNAQDTALLQRTFDFLFSGHVKTQDFMYFFASLSSNPRSRRTLWETVKARFDELVKSFEGNFSLANLIKSSISTFTSDKDAADIRQFFEKRDTSKFSMSLAQGLDSVHAQARWLERDVTDVQSWLQSKGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAC4</accession>
    <name>A8QAC4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729216.1">
        <property type="nucleotide sequence ID" value="XM_001729164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAC4"/>
    <dbReference type="STRING" id="425265.A8QAC4"/>
    <dbReference type="GeneID" id="5853522"/>
    <dbReference type="KEGG" id="mgl:MGL_3683"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3683"/>
    <dbReference type="InParanoid" id="A8QAC4"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="924"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="862"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="879"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1107" mass="116605" checksum="61DF3B6901C4AC11" modified="2008-01-15" version="1">MCQNIIDSTTFSTVDGRIRCLHCQQHSTTPLMEKEPTFTVTTPGRASHASPESSTTSPSMVKQAPGKDHTSAPEPNPASSPIPIPTQVPAPAPAPAPMSASAPVSSPASMPALAPVDALTTDSAQDSVSATPMGLSDGGVSRRVSNDSHTQERLSDVIQSEILQAYYANQTGHSTPSVEESRPHRMTPQPTVSSTISDLWSHTRSVTESEILRSLSMYDSEFEALISTPDFAARRSSLFGSGPSRSPIASLGLSSAKASPNPDDENASSQDPSVLSPRVPPAPPSPSNEVLPAAIDELTQLELQRHLALAELLGIQSAAQQYEASDDKSVHNRVKLVLSSLMAHLDTVKWEYRRELESLLLTRQSIQQELKPMLQVHSTLMQESQALAERIDAMTAHLSSLELSESSSSLQPVMRTSPSTSSLTSSLPLAPAAAAAPPPPPLPPRSVSPSRTQPWHVSAPGGDDVRHVDAESLPAAASAAGSGAAARPGRSPRGRTGKTSTDPVSIPNHGASDRPVASDLSVHDTSLSDWSPHVTSPPLPARSPRPSLEEPRPLFSSLSSSARPSPQHEQHAPFFAPSSAPTSSYGDTPLRTSAGSPVSVMSVPSSASVHPDPEGSAHVQQPASQEHAAQRPSHSRSHSAQVHLSSSLSSHAPKSGGSPELPEQELPTSPDLPPLPPVSPMATGDGQLPPDVSGSVSNQGDPSLSFSSAHTMGSGPSSAPSSISSYTPETYTPTVNATPVSAAAMDTLPSASPAPPAPSAGPQTVRRDASLPPLPSPRKFRWIKPRIPAASELNALSGTLLLPAHELARTPKGASSPSYVLNNASTPKADTPPYQAGRRVNDVHPPGTSSPAVSYKPARDMQPPPVPARRVTSPPPQPSASSAAATTAHPPLSSSSPSTSALSFSSPRVLPMSRPGSKNSMMGRSLIEEVELEGTAVPALVSHCVVAIEANGLEDEGLYRKSGSSQQQRQIIQLFDSGSSFDLCDLDQFNDVSAIAGVLKSYLRELPDPLIPYESLSSFVELAEKPGALSIASMRSLLSQLPVPHYETLRRLCVHLRVIHDHNTSTRMTARNLGIVFGRAYLFCHAYLPLTVHSYHHAFQRASDGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAD3</accession>
    <name>A8QAD3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3692</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729225.1">
        <property type="nucleotide sequence ID" value="XM_001729173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAD3"/>
    <dbReference type="FunCoup" id="A8QAD3">
        <property type="interactions" value="516"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAD3"/>
    <dbReference type="GeneID" id="5853531"/>
    <dbReference type="KEGG" id="mgl:MGL_3692"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3692"/>
    <dbReference type="InParanoid" id="A8QAD3"/>
    <dbReference type="OMA" id="ECHMIEW"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="37"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="337" mass="39767" checksum="F5C1A9764367958A" modified="2008-01-15" version="1">MAGLSVARVYANANEARGREWWDYDNLTLQWGTQDNFEILQKVGRGKYSEVFEGVNVASPDFDKCIIKVLKPVKKKKIKREIKILQNLMGGPNVVQLIDVVRDPQSKTPSIITEYINNTDFKVLYPTFSDYDVRYYIFELLKALDFCHSRGIMHRDVKPHNVMIDHEKRQLRLIDWGLAEFYHPYTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGCMFASMIFRKEPFFHGHDNYDQLVKICKVLGTDEFFVYLDKYKIELDSHYDVILGRYPRKPWPRFVTPENQHFVSDEAIDFLDKLLRYDHQERLTAQEAQQHPFFDPVRATLTSAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAD6</accession>
    <name>A8QAD6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AVL9/DENND6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729228.1">
        <property type="nucleotide sequence ID" value="XM_001729176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAD6"/>
    <dbReference type="FunCoup" id="A8QAD6">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="GeneID" id="5853534"/>
    <dbReference type="KEGG" id="mgl:MGL_3695"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3695"/>
    <dbReference type="InParanoid" id="A8QAD6"/>
    <dbReference type="OMA" id="SHADRRW"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AVL9/DENND6" evidence="2">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="458" mass="50051" checksum="51E33942D4C1EBB1" modified="2008-01-15" version="1">MFYGYPVEHLCTLQYSLISLVPALLPHLQDAASPGLDTLSSGRSKADSLRMSDRQSLLTYMGLPLPLFSGGAFFQPYCPLQQIDTLKCDSWLIGTTNQVFKHQRASQPDVIVDVRCCHCSQVQLDKMQLSFHDPALQSLVSLTPADRKWMDEVIGVVQTTWNSADPAQPTLMQYKGSDDYLRARFEEYVFGLLSLAKHRELHPTMNELPSISSFGRDFLDAFRRTRAFQTWHQFTDESLCELISYQHPCTGKTTTLSDVTIRLQAGISDLNLEENLAPTRERLGAAWQAGSAGLSRVAMNWRQDLGRMTASYTRNTSPNATDATASKGSDTLSALQATGAQGAAALSQLGSYLSSRQRAWYGAFSKTPKRGDTAESSPTSSRPSEEMIDAKKANASVFGAEGGKAAPTHRASASDTSAAPAATRPNEKEKDNHTTSSNENDSASKETSTESTKASHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAH5</accession>
    <name>A8QAH5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3734</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729267.1">
        <property type="nucleotide sequence ID" value="XM_001729215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAH5"/>
    <dbReference type="FunCoup" id="A8QAH5">
        <property type="interactions" value="663"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAH5"/>
    <dbReference type="GeneID" id="5853573"/>
    <dbReference type="KEGG" id="mgl:MGL_3734"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3734"/>
    <dbReference type="InParanoid" id="A8QAH5"/>
    <dbReference type="OMA" id="GMVEYWR"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="489"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="647" mass="72760" checksum="AE2904C9BC75D760" modified="2008-01-15" version="1">MSKEERKRFAPEDAEVSSEEDVGPMPGPAADGESEAERIKRRKTLQHERLYMDQLPCADRYVKSLMHRDTINFVQVTPHTDFIITTSVDGHVKFWKKQASGIEFVKHYNAHLSMIVGVATSADGAYFASIAADGSVKVFDVINFDLIHMFELPYTPRTCAWVHRRGSVDAVLAIAEEHSTAIHFYDGRGSDSTPLYSAEHVHKKPCHILTYNEPWDCLVSADVSGMIEYWHPREPYAIPQGLFSLKSATDLFEFKKTRSVPTTLSLSPDQKQFVTTSICDRQVRVFDFQRGKLLRKYDESLTAIQEMQQADTAVYQLDDMEFGRRLALERDIDASSLAGLADATANATGASTMNAVFDQSGHFVIYSTMLGIKVVNLKTNRVRRLLGKDESMRFMHLSLFQGIPTKKPATNIALAASNNPLAQSEQRQDPTLFCTAYKRNRFYMFTRNEPETDPNSKLAGQDRDVFNEKPTREEQAIASDTPDVKKKQVVTSAILHTTAGDIHLQLFPHLVPKTVENFVGLAKKGYYNGVIFHRVIKKFMIQTGDPRGDGTGGESLWGGEFEDEITRELRHDRPYTLSMANAGPNTNGSQFFITTVPTPWLDNKHSVFGRATSGLDVIHKIEHAPINRFDKPKEDIQIFSISLHGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAI6</accession>
    <name>A8QAI6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729278.1">
        <property type="nucleotide sequence ID" value="XM_001729226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAI6"/>
    <dbReference type="FunCoup" id="A8QAI6">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAI6"/>
    <dbReference type="GeneID" id="5853584"/>
    <dbReference type="KEGG" id="mgl:MGL_3745"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3745"/>
    <dbReference type="InParanoid" id="A8QAI6"/>
    <dbReference type="OMA" id="YIRDAWK"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="204" mass="24009" checksum="CECA03B73568C265" modified="2008-01-15" version="1">MGAYKYLEELYKKKQSDVLRFLLRVRCWEYRQLNVVHRASRPSRPDKARRLGYKSKQGYVIYRVRVRRGNRKKHAPKGATYGKPVHQGVNKLKPQRSLRALAEERVGRKVSNLRVLNSYWVNQDGVYKYFEVICVDPHHKAIRRDARINWIVDAVHKHRECRGLTGAGKKSRGIGKGHRFNNTIGGGRSAAYRKRQTLQLRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAM8</accession>
    <name>A8QAM8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3787</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728999.1">
        <property type="nucleotide sequence ID" value="XM_001728947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAM8"/>
    <dbReference type="FunCoup" id="A8QAM8">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAM8"/>
    <dbReference type="GeneID" id="5853306"/>
    <dbReference type="KEGG" id="mgl:MGL_3787"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3787"/>
    <dbReference type="InParanoid" id="A8QAM8"/>
    <dbReference type="OMA" id="QPIINGE"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="164"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP41785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="537" mass="58728" checksum="EC9B62A8B21CD897" modified="2008-01-15" version="1">MDPDDRTTRRRSGRVLEKARATGDTQRESPVMTSSRVPTSTKVQSTPKSGRSRNSLSRTSPQPSQPQQRPPSTTPSAPASTPKRRKTEAQRASAPTLPDLPLPSLPRRPHSLHSLPASVLARMTPHERVRRLLHVGATPESLPCRDEQFQAVVDCTSDVLRAGAGGCAYICGVPGTGKTATVREAVRTLQAMQERGHLPSFTFVEINGMKLASPMQAYTELWCAISGDRHRLHPRAALTRLSSHFHAPAPAGRQPTVVLMDELDLFVTSRQDVIYNMFHWPDMPGSQLMVLAVANTMDLPERTLQPKVASRLGMTRIPFMPYTNRQLLDIVRARLNVDESGNRCSDAPATLGCESVFKMDALVFASKRVANVSGDARRMLDVCRRAVEAAEERAAAHHTAPSPITIHEIRDVMDRMARSGRAAHIAALSLHAKLLLASMYACMRRTGVSEVVWGDILTHHQALCRTHAHAECNEHELLRPLATLCQLGLVIAVGSGAGHARGGVFSRFLLAVQEDEVYGALGDDAELQALFALRSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAQ9</accession>
    <name>A8QAQ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3813</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729025.1">
        <property type="nucleotide sequence ID" value="XM_001728973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAQ9"/>
    <dbReference type="FunCoup" id="A8QAQ9">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAQ9"/>
    <dbReference type="GeneID" id="5853332"/>
    <dbReference type="KEGG" id="mgl:MGL_3813"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3813"/>
    <dbReference type="InParanoid" id="A8QAQ9"/>
    <dbReference type="OMA" id="QQYQERW"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="730" mass="79603" checksum="3FCCB6961231242D" modified="2008-01-15" version="1">MNVGELLTNSLSPARDNYPMYMTSLSAELATETSPVHIRTASGLALKNALAAREARRAQDYAERWVSLPADARDQVKSKVLMTLCSSEHRAGTVAAQVTAAVAAIELPRGMWPDLVSQLLAAIGDLTNPYQRQAALQAIGFTCEVVDPAVLATQSNEILTAVIQGARKEETSPEVQLAALQALLNSLEFVRLNFEREGERNFIMQVVCEATQSAHVPVKVAAFENLVRIMQLYYDKMRFYMEQALFGLTVLGMRDPEPKVALQAVEFWSTVCDEEIELSLEAAEALEFNEEPTHVSYHFAQIALPEIAPVLMELLTVQDEDSDEDEWDTAKAAGTCLGLLAQVVGDQIVSLAVPFIEGNIKSPDWRRRDAALMCFGSIMDGPESSLLMTLVTQALPTVLETLHDSSAAVKDTTAWTLGRMCEFVHDAITPDMHLGALIHALLGSLHDEPRIVTHSCWALINLTEHKGILASLDDPDPPTTALSPYFETIAAQLMQVTDRATNESNSRTSAYEALASTVANSASDCLNQVSTVLVHILERQEALNAMVSQLIGLDDRNNWAELQSNLCSVMIAAVRRLHSGMAPIGDRLMTSLLTLIQNSAKQPTVLEDAFVAVGTVIVALEADFEKYLDAFLPFLVEGLRNHEEHQLCTISVGIVGDVCRSLAERATKYSETLVLALFEDLQSPVLHRNVKPHILSCFGDIAMAIGPAFESYLADGHGRPAAGEHGAECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAV4</accession>
    <name>A8QAV4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729049.1">
        <property type="nucleotide sequence ID" value="XM_001728997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAV4"/>
    <dbReference type="STRING" id="425265.A8QAV4"/>
    <dbReference type="GeneID" id="5853356"/>
    <dbReference type="KEGG" id="mgl:MGL_3837"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3837"/>
    <dbReference type="InParanoid" id="A8QAV4"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="106"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="226" mass="24753" checksum="05728EE6FF2AD3F5" modified="2008-01-15" version="1">MPEWGGVPAAAPEGKEAVDADFSASSSPSSFFARRRNQHVEAEERPDSDPDTTPVPPARKPPVVLGPDGKPCRACSSKLAFGSALRAASRSSTNTSSAPVPPQDDCPPDVEELGRATWTFLHSAAAYYPNEPSDIQRRSMRALLDALPHVYPCSVCAEDLGRAYATSDIASEHARERAVQSGPGLRRWLCEVHNQVNEKLGKPVWDCNDVKRLAFRWFEPPEEREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAY4</accession>
    <name>A8QAY4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_3853</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729065.1">
        <property type="nucleotide sequence ID" value="XM_001729013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAY4"/>
    <dbReference type="FunCoup" id="A8QAY4">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAY4"/>
    <dbReference type="GeneID" id="5853372"/>
    <dbReference type="KEGG" id="mgl:MGL_3853"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3853"/>
    <dbReference type="InParanoid" id="A8QAY4"/>
    <dbReference type="OMA" id="TTMIAGW"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="323"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="397"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP41851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="769" mass="87836" checksum="5F7FC9575BFFFEA8" modified="2008-01-15" version="1">MVQDTRQSRHRNASASRKAKLAPKVNESEKTSVSSLYGLSPAMVNTAITVGLCATAFYVRAYQIELPNEVVFDEVHFGKFAAYYVTRRYFFDVHPPLAKMMIAAVAWLAGFDGKFEFDNIGDSYIENNVPYKPIRLFIAAVGSLHVPLVFQILRETGTSTTMALIAALAILFDNAQVLQSRLILLDAPLVLFVLCSLYSYVKFYAQRYRPFQPAWWAWLTATGVSLALTISCKMVGLLTFFTIGGAVLFDLWNLLDIRRGLSMRVFVKHFCARALCLIVVPFLIYLSFFYIHFSVLTQTGSGDDFMSLEFQQTLNGNEYLETPISIHAYDSITLRHVGTNAYLHSHPSRYPLEYEDGRISSEGQQVTAYEHQDDNNLWRIEPVEPVDNEDGSFNETRRMIHHNQLIRLLHLGTNTYLMTHDVASPLMMTNMEFTTVSGDNEQEYANTLFKVMVEGATTDDIAWDSRRTSVRLVHNDTGVVMWTRADGRLPDWGYGQLEVNGDKNQREKTAIWTAMDVRPDPESPLFESRSNIPQEPLAPIPRSFLQKYTELQGLMLSHNNQLTSSHPYDSRPQSWPVVYDGVAYWSKDEAQEQIAFFGNVVSWWCASFAVLAFVAIFFTDLLCRRRGLYYLSTAERCRYLHTTGFFVYAWACHYVPFFLMHRQLFIHHYLPAHACSVLVFAGMLDFVTSRSIDLPITPAGPELPAERRRPVMRRRQGRLAQGFAFVFVLSLVAMFQFLSPFTYGNVGLSEAEVRARQILPSWRLQFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB16</accession>
    <name>A8QB16_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729081.1">
        <property type="nucleotide sequence ID" value="XM_001729029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB16"/>
    <dbReference type="STRING" id="425265.A8QB16"/>
    <dbReference type="GeneID" id="5853388"/>
    <dbReference type="KEGG" id="mgl:MGL_3869"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3869"/>
    <dbReference type="InParanoid" id="A8QB16"/>
    <dbReference type="OMA" id="NTRYCVK"/>
    <dbReference type="OrthoDB" id="360923at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13579" checksum="73C185ABCFE020B3" modified="2008-01-15" version="1">MVYIKRWGEFKAQSLDLCKRRPSKARLVLKARPKTQLLTVKVTDSSISLNFRSKSSIILNRLDEFQRDMFVVMSGITPTSPKQESSGAHATEMHEETATSKPTTQTSHAKSGKKKKNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBD5</accession>
    <name>A8QBD5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728908.1">
        <property type="nucleotide sequence ID" value="XM_001728856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBD5"/>
    <dbReference type="STRING" id="425265.A8QBD5"/>
    <dbReference type="GeneID" id="5853214"/>
    <dbReference type="KEGG" id="mgl:MGL_3902"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3902"/>
    <dbReference type="InParanoid" id="A8QBD5"/>
    <dbReference type="OMA" id="STNTHYA"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14417" checksum="F194AC5D7A2DD62F" modified="2008-01-15" version="1">MAKYTTLDKPCMLIILIYIDRVCERMSGFTICSLTVHRFLCAAVVCANKALCDSFSTNTHYARVGGISLVEMNLLEKEFLNVINWRLMVTAPVMQHYYASLVQMHPNYVLGPTTGPLPNAFPAMPSSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC31</accession>
    <name>A8QC31_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728975.1">
        <property type="nucleotide sequence ID" value="XM_001728923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC31"/>
    <dbReference type="STRING" id="425265.A8QC31"/>
    <dbReference type="GeneID" id="5853281"/>
    <dbReference type="KEGG" id="mgl:MGL_3969"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3969"/>
    <dbReference type="InParanoid" id="A8QC31"/>
    <dbReference type="OMA" id="EWASVKW"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="740" mass="80468" checksum="03584129EEE306AD" modified="2008-01-15" version="1">MSRHDQWLLHSPQHKNAVLSEPIGQYVLPAVNSETASLLSGSGSSIYAESIAGVPSMSGTSRMRAAPAITSGLKTVHTYTGANDTLFVQLQTPPQTSPTFMGGSKQRGNGAVTGRVILRCTEKLKATELRLKLKCVVAIMAPRASQATNGNNTNFSGLTPSSTSTSSREQVLVQLDHRFLPSNAKYSASKDAASTNNTTGRLDRKGYYEWDFRIDIPERGTTKGWHSNEFPGIGTYYPSSYVLESEKNKVGKSEEWASVKWYLKFTVERPGLFRTNDRVLIPFIYLPPPPENVSSLLIRRQALSSQTQNLVSTISGPVILPKSLAEPASSWKTYYFPLSQLALGQPIKRSLVDKMFGSKKPKEERWGISFPGNPMATFPLRSVVPFVLTLVHSAGIPLVVHPCVSLIQKVQLRGRHVASHIQTIAHAKVFPSPLNKSGMQQWFGHVQFPKWCSPSFETALLGLEYYIQVKPLNAPESHVLQTIPLGLYCMPPRLMQTLRSSTITQSMSQAPSRRGSTVTDISSGGMANSGSTPRRRVPPVPSTPSPSTTLIPSGMTPMPVPHVPAAMPAQDPHAAGMAGIGRSHLLEARVDGQTSGMPLPVESRPSLPASALASQQTQQDQALEPTTTRANLPNFDREEQSRDTQSIYPQLTETTGDTVSVQGPHINDDVSLHEGTQPMIPDDASSDGLVHDAGPLTQEQENAWTMDILANAINEDDVAAGFDLPPSYFEATGILDHEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCM4</accession>
    <name>A8QCM4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_4025</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728858.1">
        <property type="nucleotide sequence ID" value="XM_001728806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCM4"/>
    <dbReference type="FunCoup" id="A8QCM4">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCM4"/>
    <dbReference type="GeneID" id="5853164"/>
    <dbReference type="KEGG" id="mgl:MGL_4025"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4025"/>
    <dbReference type="InParanoid" id="A8QCM4"/>
    <dbReference type="OMA" id="EEFVQWS"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="78"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP41644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="301" mass="33137" checksum="E761DEC48B28EA02" modified="2008-01-15" version="1">MYDDGGPTSTGYQRARSEAMTTPMADESMARWVQSIDATYELVRNPAIRAKYPVLAEKVASALEACESALHDYGVNGCALSFNGGKDCTVLAHILCAALRKFLNVQKDHKLLPPIRSLYVACKDPFPEVEAFISYASSQRTGYNLQLQTAHGALSSALGTYINGKAGEGVRAMFIGIRHDDPHGSSLQVRSPCDPSWPPIMRVHPILDWNYTDIWSFLRCPVLCANEREVVPPCVAGQDVGVPYCILYDYGYTSLGNRFNTIPNPELLDISTNSYKPAYRLCDGAKERFGRLPNSTSPQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCR1</accession>
    <name>A8QCR1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_4037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728870.1">
        <property type="nucleotide sequence ID" value="XM_001728818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCR1"/>
    <dbReference type="STRING" id="425265.A8QCR1"/>
    <dbReference type="ESTHER" id="malgo-a8qcr1">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="5853176"/>
    <dbReference type="KEGG" id="mgl:MGL_4037"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4037"/>
    <dbReference type="InParanoid" id="A8QCR1"/>
    <dbReference type="OMA" id="HEDGWYR"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120516">
        <property type="term" value="F:diacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122005" description="Carboxylic ester hydrolase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="92"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="631" mass="70730" checksum="A844FD29917BD7E2" modified="2008-01-15" version="1">MKSVVAIILTLLLTVAIGATADSIQAGNVGIRRHEGMFRRAKSNDNQSHNKWHGHNGNDNADNGEKDDGDHEGRNDKGSGSSDNDDVEHYLVVKTNEGRVRGFYNSTSQAYAWRGVPYGMDTSGENRFMPPKPAKKYKGVKDVTKQAKGCPQHGSGTSRAAISLFGLSTDIFKDENQSEDCLTMNIFVGKDNWESFRDSGSEGKKLPVWLNIYGGSFEWGASNVEMYQAYDLVSKNDIISVSINFRNWIFGFPQAPQLYPTKHTDDSDYQGANPGMLDIDLAIEWVYKNIDKFGGDPEKITIGGTSTGACAADNWAYTHYNKPSSKYVNGIILQSGSMTSLGRYFVADPGDDFTGDDSVWNIVAKYLGCGTSNSREQFKCMQHQRWEDVIHATFATNTSFLMTPDNITAYVDYGERLVQHRFVDAPMLLGNTKDEGNAWLIHNAYLTRILGPIITAEVWVCPTRVQAKHRRGYAPTWRYRFSPSFYIPDTPKKYQSLLTYHGSDTPYSFDTWQQLSYIPTEEAKKDKGPVFQNPLATDDNSVRAPVASLYSAAFVAFVSDPQKGLYNFHSGWPEYTPDQRSIGDFGYKNSPHFRLADSSEVDGLCPFTDAEIKENNEKWKATAQRYRSYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCS3</accession>
    <name>A8QCS3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_4041</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728874.1">
        <property type="nucleotide sequence ID" value="XM_001728822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCS3"/>
    <dbReference type="STRING" id="425265.A8QCS3"/>
    <dbReference type="GeneID" id="5853180"/>
    <dbReference type="KEGG" id="mgl:MGL_4041"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4041"/>
    <dbReference type="InParanoid" id="A8QCS3"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP41660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="38" mass="4216" checksum="619FBB8465C66BF4" modified="2008-01-15" version="1">MNIAMEDTTEHVDGVLKTTYGDAFIRGNNVLYITALDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCZ9</accession>
    <name>A8QCZ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_4067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728732.1">
        <property type="nucleotide sequence ID" value="XM_001728680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCZ9"/>
    <dbReference type="FunCoup" id="A8QCZ9">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCZ9"/>
    <dbReference type="GeneID" id="5853050"/>
    <dbReference type="KEGG" id="mgl:MGL_4067"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4067"/>
    <dbReference type="InParanoid" id="A8QCZ9"/>
    <dbReference type="OMA" id="HQNAISK"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="221" mass="24372" checksum="5F5DFA4F767487C1" modified="2008-01-15" version="1">MADAARAEQASGHGQPNAALAARIVTHHLQAYRNKRCLLVYHRERLDWLRARVWDKAGALALVLNEDRSIDPSGAASIRTLLDPAELEWLRSYAALVALYKDAFLDVLDVTWPLSQSSSSSTSFDRPSSSSGPGSASTSRARQALCGGFDVRSDAAYATTAAPNSVRPPDDVMIYVLVTRNVSDVETERGTIHLRVGERLYVRRDEVEALLLRGWLREIDP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD14</accession>
    <name>MDM34_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MDM34</name>
        <name type="ORF">MGL_4082</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728747.1">
        <property type="nucleotide sequence ID" value="XM_001728695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD14"/>
    <dbReference type="SMR" id="A8QD14"/>
    <dbReference type="FunCoup" id="A8QD14">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD14"/>
    <dbReference type="GeneID" id="5853066"/>
    <dbReference type="KEGG" id="mgl:MGL_4082"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4082"/>
    <dbReference type="InParanoid" id="A8QD14"/>
    <dbReference type="OMA" id="MSFNFTW"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1134">Transmembrane beta strand</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000384348" description="Mitochondrial distribution and morphology protein 34">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="367" mass="40274" checksum="BA59D718A3A5E0A9" modified="2008-01-15" version="1">MSFNFTWPEFSAEFYEYAVQTLTTALNRGQKPKSIVGDIHVKGLHMGRVPPELEILEIGDLSRERFRGIFRFVYAGDAHLEFSTGVQANPLARGSEDHGIFSGPMTSRGMLFAASPLTVPMRVCLSDFKLRAIVVLVVSRTKGITLVFKNDPLESVKVSSTFDSVGVIQRYLQEEIEGQLREMFRADLPSIIHRLSQDWLRTESKEKVVPTPSAQPAKPAMPPVPSDVWPSHHTADVPLSVLALEEAAPSAYASHLTKLDTASQSSQGLKDLVQPAGSHPAGARTFHTTSRVRVPSSLESNAPPTPIALSSPGGLDVAGHLAELLRANHTLSPYTPHPRLVALRTMPAHRPRSSRVHARQKRAFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD26</accession>
    <name>A8QD26_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728759.1">
        <property type="nucleotide sequence ID" value="XM_001728707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD26"/>
    <dbReference type="STRING" id="425265.A8QD26"/>
    <dbReference type="GeneID" id="5853040"/>
    <dbReference type="KEGG" id="mgl:MGL_4094"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4094"/>
    <dbReference type="InParanoid" id="A8QD26"/>
    <dbReference type="OrthoDB" id="3041178at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="918" mass="101949" checksum="100DBE078AD4929C" modified="2008-01-15" version="1">MRCCRCRWILLETTACAFVSDAPEQRLRHGLIETIYRYPQHEAVRPHTDRLMQVMLKIVQEDTEDNATLAFKVIIDLHRAFKAVLQSQVQPFLELVQKLYLNMRSAVAEAFGTEQSPGKAVAVPGEEDALLTLSEGQDHTPGGTASLSATATASASTTTSASSTTAAAPSAPRTLLKSSQSFKVLTECPIAIVLIFQTYRHVVSSAINIFVPLIFEHCLTLQALPQRQAHEAARQRGQIFVGIAPGIKNRALFGEMVTTQVKTMSFLAYVLRGSAPIVRQYAHLLPEVNVRLLKDCPPENAVTRKELLVATRHILSTDFRVHFVGQIDTLLDERVLLGTGITIRELQRPLVVSMLADLMHHVRQELTTEQITRVINLHAQLLHDPTLAPSIQTMCVKLLLNLVETIVVKHADRSVVMLQGIFSTFLDKLPELARLGEDLRQLRGRTESNDENDVDVQAKDSAEQTQMAQLAITIEQAKLIQSSVAVLEHVADPMKNARFLFRNLLFGFKTLVTVFKHRGIPEPDGEVMGRVFVGGVRCCLLQTQRDGREEKDMIDLFTNIFIDLPPETFHEVFSTHMPFLFEQILQAPALLGIPQNLLSNDAVTRRFVDILLKFLVQRLDALGTPDKTPASVSLRLFKMAFMAVTIFPEENESVLEPHLTHLIMHSLKCASKAEEPTNYFLLLRALFRSIGGGRFELLYKDVLPLLPVLLEKLNLLLDAADPSHRDLFVDLCLTVPVRLSVLLPYLDQLMHPLVLALRSSSELVSQGLRTLELCIDNLTQEFLDPIMQPYIQDIMAALWTHLKPLPHNHQHSHTTMRILGKLGGRNRRFLQQQPTLAYHAGTTPSIALGMNGSVDKVCSAAGDGPGACKARGCRRGVPPAGVRCAHDGGRRACERRPGPRAARGAAAHHDRPVPCGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDG9</accession>
    <name>A8QDG9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_4204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000022">
        <property type="protein sequence ID" value="EDP41429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728643.1">
        <property type="nucleotide sequence ID" value="XM_001728591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDG9"/>
    <dbReference type="FunCoup" id="A8QDG9">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDG9"/>
    <dbReference type="GeneID" id="5852968"/>
    <dbReference type="KEGG" id="mgl:MGL_4204"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4204"/>
    <dbReference type="InParanoid" id="A8QDG9"/>
    <dbReference type="OMA" id="VDMSYSR"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="10"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="327" mass="35174" checksum="3EF16B2DD4F833EC" modified="2008-01-15" version="1">MKAIRIHQTGGVDVIQCDNVPVPSLGTDDVLIKPEIAGVNFIDTYFRTGLYPVELPFTLGQECGGKVARVGINVKNIQPGDRVVALVGSSFAERVIAPRSKVVKLPKELDTRTAVAAWLQGLTAVALTHTSYPVKSGDYVLVHAAAGGVGLLLVQIASSLGAHVIGTTSTTKKAERVKTMGAEHVFLYDDDLVSCVNGITNGKGVQVIYDSVGKATFEKDFDLVARLGTLVSFGQSSGLPDPIELHRLSPKNLKLLRPSLFGYVSTQEELNYYSKILIDLLVSDKVYPGVWREYLLSADGVKEAQDELASRSTTGKLLIRIPPTADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDL5</accession>
    <name>A8QDL5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_4221</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000022">
        <property type="protein sequence ID" value="EDP41446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728660.1">
        <property type="nucleotide sequence ID" value="XM_001728608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDL5"/>
    <dbReference type="FunCoup" id="A8QDL5">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDL5"/>
    <dbReference type="GeneID" id="5852949"/>
    <dbReference type="KEGG" id="mgl:MGL_4221"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4221"/>
    <dbReference type="InParanoid" id="A8QDL5"/>
    <dbReference type="OMA" id="ESIGIMW"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12303">
        <property type="entry name" value="RRM_spSet1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="585"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="684" mass="77232" checksum="7DA30923654C3897" modified="2008-01-15" version="1">MNDARLDDPSSSKALLPSEIPSSGRNYQTIHDPQLGRNKEMLRRYETHPRRSTTDPRMLSHHNKPPKSSRLKPRKHLEHLHYKYDDHSVGPPPPREIVICHLSPLTTPAPVLQQCRAFGAIDASELKVDPQTGESIGIMWVCFGGPRLDDASEAASNARRALDGQRMGPAFVQVFLDHDRKVYVQQYRALLKERYARKHQALAREREHEQKRLREELRERERQIRSSMRKRPNSYEPHSHSKNEPMSAVIAHRLSNLGHPYIFIPRMFSNTTDAESIRAYFSSFAPVLVERDHLGWYVGFEDHDAAFRCKMVLGSGTLHGCRLRFDIREPEDRGSNTEPSLTPNPALPLSSEKIRPTSTKTTWSTDELVSEATSRILADFTSIILRDIKTRTVTPLIAHFLRSDGKGGAIIASHKSHSLSRSTSLGSVIPSFRRLDSIPKRAPVDQKGAVQDKLSLTSDSRAFLDPVGIGLAQDDEEMYLLDLVLRGQHAQECPPIATPDAPDLHEAGSARAQGFYRIPAAEKAAHLADRNRAVVEATSATRSLASARNNRADSRRLALDIEQNRRETLADTDILHVNQLQTRKKQLRFAKSPIHDWGLFAMEHISAGDMVIEYVGEVVRQQVADHREKMYERSGNFSTYLFRVDDDVVVDATRKGNIARLMNCQTDCSPWAGVDLRLQVCVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QEN4</accession>
    <name>A8QEN4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000037">
        <property type="protein sequence ID" value="EDP41371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728585.1">
        <property type="nucleotide sequence ID" value="XM_001728533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QEN4"/>
    <dbReference type="STRING" id="425265.A8QEN4"/>
    <dbReference type="GeneID" id="5852894"/>
    <dbReference type="KEGG" id="mgl:MGL_4274"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4274"/>
    <dbReference type="InParanoid" id="A8QEN4"/>
    <dbReference type="OMA" id="WFQLYWL"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF143">
        <property type="entry name" value="FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASE PB1A11.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="324"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="399" mass="43549" checksum="E2316E472EFC706B" modified="2008-01-15" version="1">MEPAKLIAETFENGCNNEFTTFGFRFSQWEEKARQILSANSYGYVKGSAGDGYTDNQECQDFKKWHFVPRRLVPVAQCDVVPKYKVLGQNVPSPIAVAPIGVNTIFHREGECGMSAAAKEAGVTYIMSSASSTSLEDVAKANGDGHRFFQLYWPPNECNDVTASILRRAKQAGFTALVVTLDTYTLGYRPTDLNHGFNPFLLPEITGCGLGLSDPVFQEQFKQKHGKTVMEDLATSAPEWASKMFCGAGHSWDDLKYLREYWDGPIVLKGIMDVEDAKLAVKHGMDGIVVSSHGGRQVNDSVSSIEVLPEIVDAVGDKLDVLFDSGIRSGTDIAKALALGAKMVLVGRPCVYGLAMGGQKGALHVLRCLLADLELSMRLCGVASIEKEELNPSRLRLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8QES1</accession>
    <name>A8QES1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_4281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000046">
        <property type="protein sequence ID" value="EDP41366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728580.1">
        <property type="nucleotide sequence ID" value="XM_001728528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QES1"/>
    <dbReference type="STRING" id="425265.A8QES1"/>
    <dbReference type="GeneID" id="5852888"/>
    <dbReference type="KEGG" id="mgl:MGL_4281"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4281"/>
    <dbReference type="InParanoid" id="A8QES1"/>
    <dbReference type="OMA" id="ANLAYIW"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727337" description="Sodium/calcium exchanger membrane region domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="194" mass="21056" checksum="CC97CF784FA0E0F3" modified="2008-01-15" version="1">MFVLWLLVLFSVLGLVASDFFCPNLSSIAAKWGMSDSIVGVTLLALGNGFPDVVSTFRAMDKDAGTMAMGEIMGAAVFTVAIVCGSIMVFYSFDIPPVAFVRDVGTYMLASLYEGHQHIQKAADDGMIKSTSLISSLLNPKNFAFSNHIFRCAASQESVNCNNDGDSEYCGHKGRTEYDHLWIYGQGKVPRSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR32</accession>
    <name>A8PR32_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732813.1">
        <property type="nucleotide sequence ID" value="XM_001732761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR32"/>
    <dbReference type="FunCoup" id="A8PR32">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR32"/>
    <dbReference type="GeneID" id="5857119"/>
    <dbReference type="KEGG" id="mgl:MGL_0588"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0588"/>
    <dbReference type="InParanoid" id="A8PR32"/>
    <dbReference type="OMA" id="WDYVVVT"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000609">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF26">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="204"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="337" mass="36806" checksum="775FEE199DCB59D6" modified="2008-01-15" version="1">MPFNVLVVGAGAVGCFYGSKLDPEHTRVSLVCRSNYELAKTQGFELETHSFGTYQFTPHSVYATVEEAAALASEPWDYVCVATKALSMDLSSVEFLAPVISETTTIVLLQNGVDIEAPYRERYPRTPIISAVTVISAAKTHPTRIVQYRWTRISLGPYTDLHGSATTPEARALLNRTEDRVRDFAELLTRGGIKDAETYDALGIQLVRWHKLCINASMNTSGVLAGGRSNPDMVRDPALRKHIEACMHEVLEATPSVFGCPMPDKFASPAKLLESTARNTSQSASSMVQDWKAGHALELDAILGNAIRVAEAHGASMPRLQSMYALLQSAEAMRAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR57</accession>
    <name>A8PR57_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0609</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732834.1">
        <property type="nucleotide sequence ID" value="XM_001732782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR57"/>
    <dbReference type="FunCoup" id="A8PR57">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR57"/>
    <dbReference type="GeneID" id="5857140"/>
    <dbReference type="KEGG" id="mgl:MGL_0609"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0609"/>
    <dbReference type="InParanoid" id="A8PR57"/>
    <dbReference type="OMA" id="CYETSIC"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP45620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="372" mass="41275" checksum="EE775CB8EE9B100D" modified="2008-01-15" version="1">MKPARLALTNRLVHGYGLHKYMSVYSPRWASREELEMFHDSDYVDFLSTATPSTPLSSAFTRFNFADDCPVFDGMYDFCRAYAGSSLAAARRLAAGATDIAINWTGGLHHAKKFEASGFCYINDIVLAILELLRTFPRVLYIDIDIHHGDGVQEAFYTSNRVMTVSFHKYGNDFFPCTGDISETGVGLGKHFCLNVPLQDGIDDGAYVCLFKSVIEPCVYTFQPSAIVLQCGADSLGLDRLGCFNLSIAAHGECVAFTKAFGLPMLVLGGGGYTIRNVARCWTYETSVLTGTQIPDDLPHTPYDAFFAPTHRLHEPLIARVENQNTRTSLERTRIQVLEKLRYLHGAPSVQMNELPPDLAGGWVDEPIKDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRL0</accession>
    <name>A8PRL0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732301.1">
        <property type="nucleotide sequence ID" value="XM_001732249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRL0"/>
    <dbReference type="STRING" id="425265.A8PRL0"/>
    <dbReference type="GeneID" id="5856607"/>
    <dbReference type="KEGG" id="mgl:MGL_0076"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0076"/>
    <dbReference type="InParanoid" id="A8PRL0"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="464"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="703" mass="78616" checksum="1451CE5BA228FBBB" modified="2008-01-15" version="1">MNAPGHAPIALWRMMTTRWICVLNDMASEHMLGRLVAFLQDTLQDTPCNTPRGMLSELSHYLLRNAQFLEQNRWQAAVLRHVLASTESLVDVSQALASVRILALVPVEYCSRQHVSILAPRLWCLDAHLMQEHSLLTAHGRAASELKLLLRRWWTSFPHTMKLSTTCLTDYVDMLLSMPWDPLASLTQELYENSSISLLQVLLPHCDDASVPMEKWMSIALANEPGGKRYVARHVMAEILEFAVEIKPRWFSFSAPMASSLDWLKMTLMVALEPIRTHSWASVSPLEQAFFLRVLSAQIRCLPQDSSVDELATMLSHAIEFLCASVREDCSLAERLAPLAHSLFTCATTLGPMLHEKHYFYVTCAFVSFSAAFCDKATQLTPLYLSVLAKMDTQSFESTLNAIASLFESDSCCFIHELSSFLHVLCLMLEHAPAGTSHASSRCISALLLCLTTLAMKLPALTRSIVDWLSCVCQHRARVLRPFDVPRILALVGTLLGPCASTTRTDACTDAPWIFRGICAALRSIVRQRKDLVTPCLPHLTDILSQQLRLLSHMLRAHPGLAILRRIHASTPCWIDIVEHPLGVTEAQAFRRLLTELEGKTSVASLGVKRARTETRSITESLAKPMSKYAVYIMVAYVRCVTMPDTTITAALRQELQPGMFALCNMCGDFERDAALKSMLDAAGQLVFKSIWTQWDAQRYKGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-03-08" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRN6</accession>
    <name>CHO2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="1">PE methyltransferase</shortName>
            <shortName evidence="1">PEAMT</shortName>
            <shortName evidence="1">PEMT</shortName>
            <ecNumber evidence="1">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CHO2</name>
        <name type="ORF">MGL_0093</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732318.1">
        <property type="nucleotide sequence ID" value="XM_001732266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRN6"/>
    <dbReference type="SMR" id="A8PRN6"/>
    <dbReference type="FunCoup" id="A8PRN6">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRN6"/>
    <dbReference type="GeneID" id="5856624"/>
    <dbReference type="KEGG" id="mgl:MGL_0093"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0093"/>
    <dbReference type="InParanoid" id="A8PRN6"/>
    <dbReference type="OMA" id="RIWYSVG"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000405896" description="Phosphatidylethanolamine N-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="138"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="221"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="303"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="326"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="468"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="525"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="554"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="616"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="970" mass="109788" checksum="FE73F36210AA96AC" modified="2008-01-15" version="1">MKAESSSMAEWHASEGLRQRYALDEAKQGDASRKESVQDELTDTKDDPAAEAMGGSPSMVLGRTPDGRLFHVIDTPDMVTSIFRLDRPKAPLDILTLVLLLWQVCLFCVLPRKQAQVFFAVYFAFWRIMYNVGLGYVLTKQSRSRWIVRMLDSSGWLDACKNPRMHAWVQYHFKTKLGASSQRIAAAPIDFQAWILFRSVVDVILLNDVTAYAFFALSNIQGLGEHGVLLFVIRWLLGLLLLAFNAWVKLDAHRVVKDYAWYWGDCFFLCLQKLKFDGVYEVAPDPMYSIGYIGYYGLSLLTGSYAVLYVSLAAHASQLLFLVLFENPHMDRVYGERVPIAARVSERRPSDVPPATGVQRSREEIRTPQLAGAASAANGSYATSERGTAAVPSPPCTNVHDLHHRLFRNDNVVLSHIDLFRSSDFLLVLCLIYALSPLVLTRCGPRALLLFATIHAVAWRLFHSFGLGFALRWQSEERWIVHHFLKHYHFADGQAAVTESFSHWKTIYNTSLIMTYVSFALLAIRSYTSWTDNIYRLRYVLGVLLILVHMWSARSSYRVLGPFGWLYGDFFIDAYPKRLSYTGIYRFLNNPERSMGSAAFFGMALLSGSLTATVVAQLAHLSHWWFLGCVEGPHMRRLYGADVRQDSGVTKQLRQLCQSQWLRAAQPSIEELQGILQRAQGVVRQLLEQSRPRLERLADDTCALLQQKAEHVLTMHTGDSVQQIDQAKYRVTPVASPHTHEQRFHVGEPIIVQWMAAENHSRRDWIGLYAVNALDAHPDEHHGSLLVTRTTSRGKWLGVAEDEWEGHVHVGLTQSPLGTHGVSSVDTDTHQVSGVSVFQGSRLPWAAPGTYELRYHHDNTHYVLAKSERFTIYADSPEDPYSFDETFMILSKILRYALVEAPSTTSAAAHEYESADKADLTLWTQDQAQHIRDGIWSAFHVDFTKDVVIASANTTLLTRDILMARQLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRN8</accession>
    <name>A8PRN8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase</fullName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_0094</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732319.1">
        <property type="nucleotide sequence ID" value="XM_001732267.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PRN8">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRN8"/>
    <dbReference type="GeneID" id="5856625"/>
    <dbReference type="KEGG" id="mgl:MGL_0094"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0094"/>
    <dbReference type="InParanoid" id="A8PRN8"/>
    <dbReference type="OMA" id="GRNKMGF"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000024">
        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="19">
        <location>
            <begin position="14"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="18">
        <location>
            <begin position="64"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="16">
        <location>
            <begin position="701"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="15">
        <location>
            <begin position="876"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="17">
        <location>
            <begin position="1388"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP45105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1491" mass="168234" checksum="B9B9713A02666412" modified="2008-01-15" version="1">MPASRPERALDLFITNVEYTVQESGSFDTYRSAFGINGCLPRVPVIRAYGATRHGQRCCLHVHNVFPYLYIEYHGSLEPTNGTCQIRGFADPDVVLDYIDELGHAVQTAIAASLRLSPTRKHFLAAIHLCKGTPFYGYHVRPAYYLKISYVDPAIRHRLRALLEQGHVLNTVFQPYEAHVQYHLQWMMDYNVYGCDWMHIESVSYRSSVDKAVPQDSYCAVEADTWAHSIKNRRYIHASEPGGSQPSLNVQEDPVVPSLRALWSQDRERRAYWDLGPTPPSAMDERECRSRLPAADMQWDASPRLNAAWHERVGRAYRDHHDVAVHELDKYVLAAYQTVELFHENGYDHVGWEDESGRSAKMFDYAQSQTSSLMGTTQATPIPEPTSPPNFSSHETSDFVPSTFPNESPIPVPVSQTDRLPQRSPVPPLALAALAAPPMQLPTCMPSSLYTYKVPPPTQVQLEDSWSQFQQPRVLYETCHYSSTADVPRQAHEYGGQVKTLPSTGLDGLDGFRGSTSSRVARSLSQIRYWQWAHAPPSQVDVQAWLTMQDTKEQGDEQKRHYKLQARNADLLTGRAKRADQAVSWQHEPSLSDPSRRSCAGRSPPLEKKHLSTLCMDLLVCTRGDLGPDSMRDPISAVVYTWMDEAQSDVDFKHAQHGMHHNSDADGHACDWQQEARHASRSGIILVRDSGLPIKLGLREPITVVDSEVALFHNLVDLVRMWDPDILAGYDVARTSWGFLVRRASAVPALDMDIVYELGRMRTQSAVGAMTDWSASTTSSLRICGRHVLNVWRLMRTHIALTQYTLEHVVMNVLHRRTPVYSCATLTEWLRSYRAADVARALRYALRRVRFCVALLDKTEMITRTAEFARMYGVDFFSVLSRGSQFRVESVLLRITKPRSYVLPSPNRAQVAQQNAPECLPLVLEPCSGMYRGPVVVLDFQSLYPTMMMAYNLCYSTCVGRVTPFKGSYKLGFTQHAELPPRTAAAPVASPATAWQQQSQEQQQQDTNVYILPNGLAFVRPHIREGILPRMLHEVLSARIMTKHTLKRLPKEAGHVPQRRLQAQQLALKLLANVTYGYCGATASGRMPCVEIADAIVQSARETLEKAMALIEQTPEWGADIVYGDTDSIFVHLPGQSKDDAFRIGHEIAERITAMNPAPVRLNFEKVYLPCMLVAKKRYAGYRFDTKEQARATLDVKGLEMIRRDGHVALQRMQETCLRILFETHDMTAMKRYCQRQWAKLYTNDVLPLYLLMSKEVRMGTYASGASMPPGAAVAMQRMRHDPAYMPHAAERVPYLIQHGAPSAKLQDLALSPHELLRVWPLALHMEYYVRRTILPALDRLLGLVGVNVYAWLEDMPKQVGRPRRPLLCLPPTRPNAPTLLQTLAHTCLVCGNPGTSQAHPFCIDCLRNPETSMQRITSAQHAAEAQQLGLHHICTACAQEMERPPCEAIDCAVLYKRISNDRLVQHLHALPGDLERDLEQTKPGSDAWTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRP1</accession>
    <name>A8PRP1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732321.1">
        <property type="nucleotide sequence ID" value="XM_001732269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRP1"/>
    <dbReference type="STRING" id="425265.A8PRP1"/>
    <dbReference type="GeneID" id="5856627"/>
    <dbReference type="KEGG" id="mgl:MGL_0096"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0096"/>
    <dbReference type="InParanoid" id="A8PRP1"/>
    <dbReference type="OMA" id="MRIELCQ"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="122"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="300" mass="35073" checksum="85ECE51B5ED7A925" modified="2008-01-15" version="1">MAPFFGHKRRSSRQHEDDHPEQMTTEVKLEPSPECKLLPARKIDSADEEKIQALAECIRDYRATNPCSPDYDEYEQKWFMDPLMYLRVLRSVRGDMKHAKKRILETLQWRRDYRPDLIPPDEVAPEAETGKHVINGFDKESRPIIYLRPGRENTKASPRQIRYLVWTLERAIDLLQPDQETLTIVVDFHDTHLSSMPSLGTARHVAHILQTYYVERLGRAFVCNSPRFISAFFSALSPFLDAVTKDKIRFNYPDMTDFIPPDQLDAQFTGGQYYYKFDFPTYWNALVQRCGIAPDGTHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRT7</accession>
    <name>A8PRT7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732350.1">
        <property type="nucleotide sequence ID" value="XM_001732298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRT7"/>
    <dbReference type="FunCoup" id="A8PRT7">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRT7"/>
    <dbReference type="GeneID" id="5856656"/>
    <dbReference type="KEGG" id="mgl:MGL_0125"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0125"/>
    <dbReference type="InParanoid" id="A8PRT7"/>
    <dbReference type="OMA" id="IIYEPIR"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="372" mass="41127" checksum="0921C651ED4FF204" modified="2008-01-15" version="1">MPSEVPAPSLTLGRPFRKGGSASSRSVCSDGDAVRATDSDALGSRLAACRAGYLTPDVYAELLATEAPVPSLSIRRPPLISIGTYLRSCETDSLVQHFIDTGTIGPTDSFDGRALSSPSKVQIISLGAGSDTRFWRMGCVPKVARYIELDFPETTALKAACIQRHAPLHEALTDVHISEHVFESSKYVLVGADIGSLATRHEWETRVGRFLDASLPTLILCECVLAYMDVSVADEMLRTCFSTLGQVSLLSYDMCVSGDREDRPHDHIAHDTEPTRFGKVMLQNLSARKLILPGARQCTTPAAYKERFEQLARSERAYSSCSAAHTLRDAWHNLDRRERARVSMLEHLDEIEELEMLLGHYCMAWIDRIIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRU3</accession>
    <name>A8PRU3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732354.1">
        <property type="nucleotide sequence ID" value="XM_001732302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRU3"/>
    <dbReference type="STRING" id="425265.A8PRU3"/>
    <dbReference type="GeneID" id="5856660"/>
    <dbReference type="KEGG" id="mgl:MGL_0129"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0129"/>
    <dbReference type="InParanoid" id="A8PRU3"/>
    <dbReference type="OMA" id="SHVYGLM"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="122"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="704" mass="78856" checksum="397664754866747C" modified="2008-01-15" version="1">MFTKEEISARWAAHLDKQMIEVPGTAKPGFTPVYRNAAFPMDPPDDRPYNLFKKRVAENPDAKCLGHRPWDEKKNDLADYFEWRTYAQTDAEVTALGSAISWFQEQGWLKPRENDKNISEPGISGFTVAYWGANRPETMITLLSQAAYSRVSVSLYDNFDAAGSCYILQHSQTRVLLCPTQYVPIVLRNADKIPALKVIVLIDRPCPSKSMLGELKKVELVREWASMHGIHVVQYDETIALGRQNPRPHIVAGSDDQLASLCYTSGTTGLPKAARIVNGSMSQAMEGLRWIVNDQEMVSISYLPLAHILERGWETFILCMGGAIGFFSGQIERLMEDLQILKPTMMPSVPRVLNRIAGQIEAQMSAPGLKGKLLSKAVQVKLDNFYKTGAITHAFWDRLIFRKVRALLGGRVQFMITGSAPCRKDVLALLRVALCVDVREGYGQTENSAYATFMAPNDPRLGCVGPANPGVDLRLRDCPELGYMSTDMPCPRGEIMIRGKAVFDGYEGDEKKTKETFLDDDDGKGPWLLTGDVGRVDEYGRLQIIDRVKNLIKLAQGEYIAIEKVESVFASLPLVQQVWLYGDSYQPHLVAVAVPQPDTFAAFASRILQKTVKHDDQTAMQSAVNDSMVVEAVLREFIKLGKKQRLGTLEQMRALKLRLDPFSPENGLMTPTMKVKRQEAAKILKGDLDELYRRQPYDLNDVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSS7</accession>
    <name>A8PSS7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732534.1">
        <property type="nucleotide sequence ID" value="XM_001732482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSS7"/>
    <dbReference type="STRING" id="425265.A8PSS7"/>
    <dbReference type="GeneID" id="5856840"/>
    <dbReference type="KEGG" id="mgl:MGL_0309"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0309"/>
    <dbReference type="InParanoid" id="A8PSS7"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="370"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="819" mass="89961" checksum="06F8D4AB6822EC5E" modified="2008-01-15" version="1">MELGKPAAPIGQSSDSARPCCSSRFHTADDVHACMTDSNKTSAHTLHFDSADIRPSLQRSSSTPTSSGPALRSTYRSRLSLCNQMHHQYIQTDHASPSDLRHSPRAHSFQLESNSSLSHGRNRRIYGAPQTLSSSRPIKRPSHLQREKLVRAADDWAFCPSDSLPSLPASPSRVRAEHHAKDVSHRPEILPHGPFKGSFPGTHVSNHIAPQSPSFLIQRFNFKLDSTPPMQPSIFSFQGDTTQPHTTSSLASVDSDCPRQVQALSPSRIPPTMRPLSPFTMDQPCHPGRMSHHSDGPLLPVQNTDCDACVQCYQPQNNSPCTLEHGAPIAPFRVGDRIGPGLVHDNEIVRKAQANAGVDGRELSEFTKPLEIVKLLGHGSYAVVYLVREVISSYDTSTLFPLPCVPSVTSSGSSPSLPTNLDKAMTTAANAHQAQHVDTAALDSCIDAYASVQSYVAPPSNQANDSPKEYALKCLSKRNLTPDQLSFQRLEAMIHRSIPSNPNIVTLYNVYETDNWLFLVLEYCPGKDLYFWLQEANDSIGKPGWCHNSSPSSSFQPSPNGDARMSPSSRRDATRSAWLLMSRSPNSLLSKSRLQLISTMFGQMCDAVQFCHDHGVSHRDIKPENFIIQDCSQQGINDDRVVVKLTDFGLATVNERSSEFNCGSKPYMAFECRHDLTSTYDPKQADTWSLGIVLLNLIFLRSPFKEPSVQHCASFSAFCLKPVTFLMQAFDGLTEEVAHFLCDHVFCDVTHGQRRRIAPGALGNWAAGLPYMLGVHHTTSQGAHHKIDARTNNTSLLSVSEQNIGSLSSLGSKAAHGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSX0</accession>
    <name>A8PSX0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732555.1">
        <property type="nucleotide sequence ID" value="XM_001732503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSX0"/>
    <dbReference type="FunCoup" id="A8PSX0">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSX0"/>
    <dbReference type="GeneID" id="5856861"/>
    <dbReference type="KEGG" id="mgl:MGL_0330"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0330"/>
    <dbReference type="InParanoid" id="A8PSX0"/>
    <dbReference type="OMA" id="SYFDYVM"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27551" checksum="25E9659542A5BC5E" modified="2008-01-15" version="1">MTATFDSESELQQAFLQFRDEIDAYHDRRDRLIKTSRDITSLSKKVIFHLHRFSMEHAWPTYDENGQLTQTPANGRLLVSANAKLHEIYDVIRTCAMKEELASETHKPSASMLRYERCIGMSLEELVEAASFLHFLEHNSLIHHEDIQQHLRTPDGHLIMYVSPMRYLLGLCDLNGELMRLAINAAACPDPMHVIERVLSMQRAIYDGTLKSFGREGKMWLLSMSILTHATDTLQPWSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT79</accession>
    <name>A8PT79_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732606.1">
        <property type="nucleotide sequence ID" value="XM_001732554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT79"/>
    <dbReference type="STRING" id="425265.A8PT79"/>
    <dbReference type="GeneID" id="5856912"/>
    <dbReference type="KEGG" id="mgl:MGL_0381"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0381"/>
    <dbReference type="InParanoid" id="A8PT79"/>
    <dbReference type="OMA" id="NGARCIQ"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="294" mass="33346" checksum="C4DA061457382249" modified="2008-01-15" version="1">MLGEQLEGHVLPLSLGTYGCRVVQKAFERVDEKQKIRLGQELHPYVLDCVRDQNANHVIQKILEQVPSTHLDFIAAAFRGHVQILASHCYSCRVLQRIFAYCSEDQRRPLLDEMHRDTLRLMQDQYGNYVVQWVLQHGDERDRLAIVRVTKTHLPLSRHKFASNVVEHVIQVAPPTDLTDLLEELLAPLSPSDAEGLPLLLEGTSPLCIATIMMQDQYANYVLQRFLQTLHGHNRERLVQTIRPVLYALRQRQAILAAQTNAASPYTASIRIPGGGHIGNKPLQAIERLIEQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTA9</accession>
    <name>A8PTA9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitase A/isopropylmalate dehydratase small subunit swivel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732620.1">
        <property type="nucleotide sequence ID" value="XM_001732568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTA9"/>
    <dbReference type="STRING" id="425265.A8PTA9"/>
    <dbReference type="GeneID" id="5856926"/>
    <dbReference type="KEGG" id="mgl:MGL_0395"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0395"/>
    <dbReference type="InParanoid" id="A8PTA9"/>
    <dbReference type="OMA" id="CLATTHD"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="5">
        <location>
            <begin position="2"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="6">
        <location>
            <begin position="314"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="82428" checksum="DCE060E1751B8D8B" modified="2008-01-15" version="1">MSNMGAEIGATTSAFPYTPAMGRYLEATGRAAVARAASQASDSGLLSADAGAEYDKIIDIDLSKLEPSLNGPFTPDLNVKLSDFVERARREDRSHPRELSAALIGSCTNSSYADMSRCADLARQAGKRGMKVKVPFDVTPGSEQVRATVERDGIEETLTNAGARVLANACGPCIGQWKRTDKQGETNVILTSFNRNFRGRNDGNANTLNFLAAPEIVTAFAFAGRLDFNPMTDSLEAPDGSTFRFEPPAEKELPENGYALGDKTYMPEPMPMPQPDVQVMINLESERLETLQPFDSYFAAEDVARGSFELPPMRCLLRIRGKCTTDHISAAGPWLKYKGHLSNIAENTLIGATNDETGTVNEARDYVRPSSASESPNDTIPAIAKRFKARGQPWILVADHNYGEGSAREHAALQLRLFGCAVVLARSIARIAETNLRKQGVLTLLFENEHDYEKIGSGDLVETLNLTELMRPGADIAAVQVRVLVTKFHDDGSVREQFELPTRHSLSKTHLDWIRAGSALNNIRANATVAQAAASGAPFSTSSSQRTPSPLSSSSTSTDIPSGARRFSTAALRRASAPAASSSGNDPRYEQLRQLLFPAPATNKKQTGPKTLADAIGHGKASAEVYETISRAWHLHERRQKAAFAASLATKRARFDEALADLRKTDTALWKRANEYVGPTKRNMEELHRLRRMGLAQQGAGAGGASADGEAPGSRMLAKRRARLMARTRLATLFPRELRAPTMTPPAKGWPAYRPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTM2</accession>
    <name>A8PTM2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732672.1">
        <property type="nucleotide sequence ID" value="XM_001732620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTM2"/>
    <dbReference type="STRING" id="425265.A8PTM2"/>
    <dbReference type="GeneID" id="5856978"/>
    <dbReference type="KEGG" id="mgl:MGL_0447"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0447"/>
    <dbReference type="InParanoid" id="A8PTM2"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF329">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR DMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="581"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="653"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1055" mass="117985" checksum="666C0B83A51A3B81" modified="2008-01-15" version="1">MTSPTVGFFTSALFTHHALQWLWSYTVEFHPRWLCEQGMKSGGRATGGACYRRWRSIRTLPTVYAPVDHRRGDQRAKLPDGRAFRHTSAPVSPIDTFPLRRSSRASYLEHVSRAAHAVLDPPPTQPLGLGTIHRIMDLVASCVYTEKTRDARSQLRRFVGERLWPQCSSEAVAIELLALQGNLDAALSRFAALLSQHEALLRHLQAQSLQGMHTRQRGENATLDAVYRAATAVLSTWVENCMHEKAQSVYSGMTADRAAAWFWEHPLILAMAQPPFPKVVHSIYTLLSSLVDPHAHLQRVLAMQRPSDERAHFASVLVLSYANRGSPHMSAQLMNEVMASEIMPHEGAVRRVLRTIAPLRDRDLAQPLIQWLEQYSRSATTFSVLAMYYAELGDVDGMERALIRCPDSSGSLCARARLVCAASRGDVAAVHHRIGPVLQTEEDAFWLLRAHVRSNDMAGARQVFLDATQEYASERLYGEMARMVARMGHTNEALDIAAQLEGIGIVCTPTTLTYLVQALGRAHLPERAAALVARQFERGTRPALRVYTALMDAYIRVGHYVAAQGIFQWLQTQHDPSLLPDTSAYNTLLKAHVHKGTPVKHVVQFLLDMRRQRLMPDARTYALVVQSACDARRLRLAEQLFELADRSLQGGASLQLHTILIHAYLKANDTIRARELLEQVERRGMEPSYITYAVLLHSYANGTESSLQIAQDLALRLIDQASLSQEPRTWTVPALEQGPMLENLLVPLIDAHGKRGDIWEAQYLFRRLLHGSEPLSPQALTVMMNAHRSAGDVEGVLRLWDELYAMMTLRAQADVSAADTLVGSIGAAMSLTTPSADASPCIGPFQRNLLCIPLSLTIDTASRAGLHDRVAEIWTQAKRDGFAFDAQNYNHLCRALARADRVPDALSIVQHVLYESPPSLKHVDDPAPADFITHLGAKQTVTEYAANPLYQARLTLQNDARTAVPVSPPNRRKHRFTPTYLQQCQDSVDAQPDGILQDTNLLHGRELWFASLNTMRTLSEALEKHRSRRDEWLALFPRAAERLDECRKYCPRAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTS9</accession>
    <name>A8PTS9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732698.1">
        <property type="nucleotide sequence ID" value="XM_001732646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTS9"/>
    <dbReference type="STRING" id="425265.A8PTS9"/>
    <dbReference type="GeneID" id="5857004"/>
    <dbReference type="KEGG" id="mgl:MGL_0473"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0473"/>
    <dbReference type="InParanoid" id="A8PTS9"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="144" mass="16129" checksum="020E36E27AA81C5B" modified="2008-01-15" version="1">MFATKAVRYFPSAVRAEATQFLRTKRSTNIAGLEIHPDPLPELESTYTQTLRVLKTMPESAVFRQSSEAVTQQRLDIVKAAMSETSRKNAYASEAAIDQVVAQLDSGLIEEIVDQAQDELHLAAKMIDWKPYVYLIESNVSPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUB8</accession>
    <name>A8PUB8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732053.1">
        <property type="nucleotide sequence ID" value="XM_001732001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUB8"/>
    <dbReference type="FunCoup" id="A8PUB8">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUB8"/>
    <dbReference type="GeneID" id="5856371"/>
    <dbReference type="KEGG" id="mgl:MGL_0646"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0646"/>
    <dbReference type="InParanoid" id="A8PUB8"/>
    <dbReference type="OMA" id="YICLYAE"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="126" mass="13129" checksum="13EFC87DA6FD81CC" modified="2008-01-15" version="1">MSWQGYVDNNLVGTGKVSMAAIIGLKGGVWASSPGLNVSMEEQTAIIKGLDDPSPLQANGIFVSGKKYLTLQANPRSIYGKAGGDGLCVVRTNQAVLIGIYNSPLLPGDANKVVEGLADYLISVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUH0</accession>
    <name>A8PUH0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732091.1">
        <property type="nucleotide sequence ID" value="XM_001732039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUH0"/>
    <dbReference type="GeneID" id="5856397"/>
    <dbReference type="KEGG" id="mgl:MGL_0684"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0684"/>
    <dbReference type="InParanoid" id="A8PUH0"/>
    <dbReference type="OMA" id="ERCGASE"/>
    <dbReference type="OrthoDB" id="2527463at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="334" mass="37369" checksum="F1B214D16CAB7D3C" modified="2008-01-15" version="1">MGDDSRLWLATHGKSEKISGPSGEALESSHAQGGASSTNWRVPDFRSQTARESNTEFDAFQHERSALHGPNAILSNISIEQTDSNPALMERAWQQNPHYMSVKVQQDGHRFIDAIESELHAPEAGAPSHEFDSMRPLVHLEETWRPPSPSQGLSMSREQYAMHENLAKLQTGTGNDIQPFRQAESIQPPEDDAALEEGVYARTPEAALESVWNPQKARMSRVAHFREATAGSIPSSSYTKVRGQAIVDRLRGWLVREGYADEVYGLPPLTAKMFGEATMDAPDAKTEERRATAIRRLDALYRHLSISQTEKGDRRINRERCGASEMEAWLQKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUH4</accession>
    <name>A8PUH4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732094.1">
        <property type="nucleotide sequence ID" value="XM_001732042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUH4"/>
    <dbReference type="GeneID" id="5856400"/>
    <dbReference type="KEGG" id="mgl:MGL_0687"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0687"/>
    <dbReference type="InParanoid" id="A8PUH4"/>
    <dbReference type="OMA" id="PGLDCKT"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="311" mass="27424" checksum="F0F3F945275EB5D9" modified="2008-01-15" version="1">MNSQQGGYGSSGGMTGGSNGYGGSSSGYGGSNSYGSSRMDSNTSGYGGSSGGYSGSNSYGSSGYGNSSGGYGGSDSYGSSSMGGSAGGYGASSGGMSGSNNYGSSGMGGGMGHSHHHGSSSTGTGGGMNSSMGSSSGYGGSSGYGDSSSGYGGSSNGYGGSSGSYGGTSGGRGDSSSGYGGSSNGYGGSSGGYGGSSGGYGSSSGGYGGSSGGYGGSSGGYGGSSGGFGGSSSGMGSSGGYGGSESFGSSGMGSGMGGHHSSGGMGGSNGYTSGGMGGSGMGSGMGSNGYGGSSNGMGSGSGGYSGYGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUN4</accession>
    <name>A8PUN4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0727</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732134.1">
        <property type="nucleotide sequence ID" value="XM_001732082.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUN4"/>
    <dbReference type="GeneID" id="5856440"/>
    <dbReference type="KEGG" id="mgl:MGL_0727"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0727"/>
    <dbReference type="InParanoid" id="A8PUN4"/>
    <dbReference type="OMA" id="CPQDWPS"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="987"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1067"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="260"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="650"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="948"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1263"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="610"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1381"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1521" mass="170128" checksum="6756E29217F779D0" modified="2008-01-15" version="1">MASNVGSLEEKNGGYISSPPDSGNTSKMLTKGIPEQDDELALDDQHPKTKTADMNTKREDRQGNQKFGVRVREHWWQFWRFKNPPPPPPESIDDAQELPLGRTNIFSDYTYHWVAPMLSLGYRRPLEATDLWAMDGPRQAKHLSSRLVDRWDARVAKADEYNRKFDEGKVKVTSSMRRKWRNQAKKEHAQNLGGEASVEERIAAKEAIWFLPDLSVMKQIDITPEIRRKKALAGTVKSGRKRANLFLACVDIFWPHIIEAFCAKILADVAQMCSALVMEHLIGAVRDGDTGLGCGYTVVMFVMLLIGNVLSNRFFYKSLYVGVFCRAALVSGIFRRALNMQGRDRSTGKLVNHVSTDVSRIDFGAQWWLLTFTAPVEIIVCLIILLTRFGVSCLSGFALIVVVMPFQLYFMKFLFMLRAKSMQWTDRRARRTQEMLSGMRIVKLFSYESNFFKLISTLRKHELKYVFFLAVARAGLMATAISLPLLAGVLAVITYYFKNDKLDPEKVFPAITLFQLLRLPLMFLPFGISVIADGANSFIRLRDVFYAEQHDTTLTSDETSPYGLNIDNATFVWEGVEEDDTLKPVKKLNEKSNSKKKMKQKRMWAFLRRNRKDKSKGAKGPKKLNIFSRKKKGTSGGQEPVSQEVPVAAEKDAQPGKAADEDEMPFQLQNIDLKVKRGELCAIIGPVGSGKSSLLLGAIGEMARSSGQVVWSSQRVAYCSQSAWIQNATVRENILFGQPWDAKRYWDCVERSELFADFAMLQGGDMTEIGERGVTLSGGQKQRINIARALYFNADVVCLDDPLSAVDAHVGKALFNNAILPMKKQGKTVLLVTHAIQHLPLCDRIVLMDDGRIEEMGTYEELMQKGGSFYTTMYNFGMLKDEDEEDADELAAETEDAKAPPKKYTLAELSKPGAGKTMESEERNTGSVDSVVWVSYLKAGSGTLIVPIVLAAGACMQASTNLSSYWVVWWQKWHYEHRKSIGMEAGIYATLGIIQLIFNFIMDVALGLLTFLASRKLHDRAMKRVVFSPMSWFDTTPIGRIINRFGKDIDVLDNQLSNLVRQCASTVLSILGAAIMVIVFTYYFAIVVVAVFVFAYFFATFYRSSAREFKRVDALLRSTLYSHFAESLTGLTTIRAYRESDRFLHDNYKYMDLQNRAYFLTIVNQRWLGLRLDFLGSLCVLITGILCSVRVGSIDPGKTGVSLSQVVTVAQTLGFLTRQLTELENEMNSAERLVYYANNLDQEPPQQIPENKPEPAWPAHGSVELDNVWLRYRENLPNVLKGVTFSVHGGQKVGIVGRTGAGKSSILTVLLRLSEATQGRVLIDGVDVSKIGLEDLRRNIAILPQDPLLFSGTLRSNLDPFERFDDARLYDAMHRSYLTSAANASQPPTGAVTPVVGEDGQPLPSATQGEATVPAQPKALTRLTLDSIIDEEGANLSVGQRSLVSLARALVKDCKIILLDEATASVDLETDAKIQRTIRTEFADRTLLCIAHRLTTIIGYDKIIVMDDGKVAEFACATCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUP1</accession>
    <name>A8PUP1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0734</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732141.1">
        <property type="nucleotide sequence ID" value="XM_001732089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUP1"/>
    <dbReference type="FunCoup" id="A8PUP1">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUP1"/>
    <dbReference type="GeneID" id="5856447"/>
    <dbReference type="KEGG" id="mgl:MGL_0734"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0734"/>
    <dbReference type="InParanoid" id="A8PUP1"/>
    <dbReference type="OMA" id="NGLVMYP"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="14">
        <location>
            <begin position="230"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="239"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="300"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="442"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="509"/>
            <end position="510"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="522" mass="58032" checksum="B8C4571831CC9416" modified="2008-01-15" version="1">MLSSATVLPVWPPHELTEPERNKCITQDARDYALGHGLVYRALPAEQGGLPPQDVTIHAPTTIVPTPFPRALYEKAQRLQPLFNELYAKVAMDAEFLSTILENSVVKVDDFQRRLYQIWRAVLEEGGSQPMQLGLFRSDYLMHANARDELELQQVEFNTIAASFGALCTRASNMHHHLLKNGAYAGVHPSLCAENMPRNDALSTLVHGLADAHRHYLSETGQPQHMSSPAVLFVVQPNERNAFDQRAIEHELEDQHRIPVLRISLDELCTKATLHGTNRVLVVQSPLHLTPIEISVVYFRSGYGPDDYTSQDAWDVRLMLERSHAIKCPSVALQLAGSKKVQQVLAEPNVLEQFLGQSAHDVRVTFSQLWPLDESHLGQEGLELARTSPDKYVMKPQREGGSHNIYKHDIPLALDAMHKRDQERKSHGEDVAVKEHEGYILMSLINTPKDRGAMMLRAGRGDMAQTVAQTVSELGVYGTALFGVTGKESMRSGGYLLRTKASDSNEGGVAVGFSVIDTPLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUU4</accession>
    <name>A8PUU4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732181.1">
        <property type="nucleotide sequence ID" value="XM_001732129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUU4"/>
    <dbReference type="GeneID" id="5856487"/>
    <dbReference type="KEGG" id="mgl:MGL_0774"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0774"/>
    <dbReference type="InParanoid" id="A8PUU4"/>
    <dbReference type="OMA" id="HRIETQI"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="943"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="976"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1028"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1102"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="745"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1214" mass="131083" checksum="25CA5C47360C5580" modified="2008-01-15" version="1">MSHLPQSLDGGDRVYHEVADGSHEGDLSKDTFNEVIDNADVHEEEIPLRNMEHPAPPILSALSGSPPPSSMQPSATVQQHQGPDVASPESHNETLNRSQSRSARIFVHTDGRGPTITLSQPPVSPTAADSSTFRPMHSLKESTGIKRANHPGNINLEGLQPKIPDVLDHDETDMDNQLGRTGVVGVHSDDHDRLAALADELDGMDSEAVSEQPSPGHAIIRDEAFLPGLATLPPGEADPEKVPVGLDDGGLTTPGTTSDGSYDPMDDLDNVDLIEGETDGMPSKPPRSSRKKIQDQGKTGWNKLRRLLSVGGNDRNNEDLSEKGLFTSEATNLKSVPVKTSSGIRGTRHRKRPSAMDREAAKLVRAHKLLHGRADSEASDDEVDHIPDMNRDHLPDSEVSTPDALETAQSMDARPAETSGVLGQLLKLYDQQNEEESRADESQAPESVITSENGTSLGGGLNLIGHNVVDAYGNQAAIEDVDPKLLKQAAASKRSSESWRDPAKQSIYRTGGGLINLANQNITLASSVGQSVVKNVAADVGLDVMDERPKAARSGAGTIGGLIATTGNLIGAVSPLHAQLGPNPTRAGYTLDRYLLPDMNEKTLRRTAKIVAEAAPVPKKMRAAQSLTSGAPLTPNTFAAYVQNTNGTNPYFLQSDGKSVAGNSATSSLKRSGNAVGHVGKQLLHRKWPSSSASDDKADYFANANPEEVARREWKKKLRRRKMRSKKQEIFITMHVAAILKRQEFLLKLSRALMMFGAPTHRIEQQIQSTANVLEVNCRCVYFPSVMLLSFGDEATHTSETKIIKQGSVVDLTKLTDMHSIYWKVIHDKIGVEQGSKQLDALMRRKPLIPKWQLVIISGLASGFITVGEWGFKGSLLDAIASACLGAFMCFCQLSTTSELYSNVFEIVFATLNSFIAMGLHHIGQVHVNDQVHYGRYFCYKAVVAGSIVLILPGFIVLTAALELQSKNLVSGSVRLVYAIIYSVLLGLGIMIGALPLMGSRTFQIECTARDDFPHWYNTPPGQSGSPSFAWAFLTVPGYATLLSLRNQAKATRKEFPVMILIAICGWLVSNFAMIADNVNSDCMGKSDGHCPVPEVLKDHTYLYSAMGSFTVGILSNIYGRFFDGRSFVVSVPGILYQLPTGMTGSPDQATLWNLAKNPQSNTSAQGSEVTSGLQIGAQLLNISLGIAIGLFASSLLMFFLGGRKVRGGGMFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVF7</accession>
    <name>A8PVF7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731582.1">
        <property type="nucleotide sequence ID" value="XM_001731530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVF7"/>
    <dbReference type="STRING" id="425265.A8PVF7"/>
    <dbReference type="GeneID" id="5855888"/>
    <dbReference type="KEGG" id="mgl:MGL_0850"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0850"/>
    <dbReference type="InParanoid" id="A8PVF7"/>
    <dbReference type="OMA" id="QRPGWAW"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32920" checksum="4852F867547FB0E0" modified="2008-01-15" version="1">MLRLFASVARPVALPMKRTFFPAAHMRQFGSTPIRASFWDNILPLIQGNRRERQLQRKQGGLLQEDIERVQRDQRRDEMMAAQSSTGDMLIDDAMDAPEFRQENVRRQATEEKRQKRLLRKRWGGTTELGGPEKLEHKYSTAVFRISPRKLNMLAHQISGKPIDFAILQMQFSAKRAARRVRATLALARDHAEAKGMDPRRLIVSEAWVTKGLYMKRLEIKGRGRFGILEHPQARLSIILRPGKSTSARERETIVKARRHVRSLGSGGVVRGSPKIVNGFQRPGWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVU5</accession>
    <name>A8PVU5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-arabinono-1,4-lactone oxidase</fullName>
            <ecNumber evidence="2">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731690.1">
        <property type="nucleotide sequence ID" value="XM_001731638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVU5"/>
    <dbReference type="FunCoup" id="A8PVU5">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVU5"/>
    <dbReference type="GeneID" id="5855995"/>
    <dbReference type="KEGG" id="mgl:MGL_0958"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0958"/>
    <dbReference type="InParanoid" id="A8PVU5"/>
    <dbReference type="OMA" id="VSWLPRQ"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="43"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="603" mass="66439" checksum="D9C250E8C5427F35" modified="2008-01-15" version="1">MSLSALDALIDPVTLSPRSSSAHMQNWAGVYASDKASTHDGAFSHIERRVFSPNTIEQVVAIVERARRASMPVRAVGRRHSPSDLPFSLGWTIRTDELYGIVHIDKEAGEACALGGTYIKTLSAALASHDPPMCLPNLGSISEQTIAGLISTASHGSGIHFPVLSAHVVALDVVCPLSSGTEVLRCSRTERPDLFNASLCGLGATGVIVSVTLNVVPAFRLLQVTEEVPTEALLGDAVAANSMPSLSTLPPDMLSMQSYDSFIEHPAWLGIMLAHGVPLPPPRAHDLAPASRSPECVHPFEPSASAPSSPSLVPWNVATVQAHIDQLVESAQHVRFLWSPHANMITIDRANRTDAPADEPTSSIFSLRHVSPAPLIKAMLFASRFHKSLPSLAARMTHYLTHPSPPTHARDPAATPGGLHPVRTDTAISVRVDDAPRIFNFDCLCEQYTTEYAIPYEYTGAALVALRAWLNLEHAQANGERLHFPVEVRFVDADGIWMSPCYGRRSCYIGIVQYRPYGWPVRYRRLFRRFESLMRQFNGRPHWAKTHTLYRHELLLHYPHLSDWLATTAKFDPQHLLVNPYVARHIFDEHAAGRQGVFRKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW02</accession>
    <name>A8PW02_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731728.1">
        <property type="nucleotide sequence ID" value="XM_001731676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW02"/>
    <dbReference type="STRING" id="425265.A8PW02"/>
    <dbReference type="GeneID" id="5856033"/>
    <dbReference type="KEGG" id="mgl:MGL_0996"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0996"/>
    <dbReference type="InParanoid" id="A8PW02"/>
    <dbReference type="OMA" id="TTANDHF"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="315" mass="34914" checksum="290F767C40D49438" modified="2008-01-15" version="1">MPSADNATQLTVLFATETGNAEDIAYRIADIALRHHVPTRICDLHDYDRTDLINESYIIFVVSTTGNGELPVSARPLWRFLLRKGLPGDILSDLTFTTFGLGDSTYTRFCWASRMLHRRLQDLGAKEWLPSGEADEQHELGLDGGVLPWLDSLVQHLKQDLCEPNGPSPISNDVLLPPRIEAHVVQAATQPADKQGCVRCDAPSPPTDPATKAFSSARLDDSTMYATVVKNDRMTDKSHFQDVRCIELALPSNTPVPAYHAGDVVCVRPENKAADVDWLLERLGWSSFADDALTLTRHDPRTYTRASPWSLTPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW62</accession>
    <name>A8PW62_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731765.1">
        <property type="nucleotide sequence ID" value="XM_001731713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW62"/>
    <dbReference type="FunCoup" id="A8PW62">
        <property type="interactions" value="762"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW62"/>
    <dbReference type="GeneID" id="5856070"/>
    <dbReference type="KEGG" id="mgl:MGL_1033"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1033"/>
    <dbReference type="InParanoid" id="A8PW62"/>
    <dbReference type="OMA" id="PNYREYM"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="244" mass="27868" checksum="B5C21240BB835061" modified="2008-01-15" version="1">MKLTAELLAQCDSSINTLKERELDLRGFKIPAIENLGASRDLNDTIDLTDNDVRYLGNFPRMLRLRNLTFSNNLISRIDPHIHKQLPYLESLVLTNNAVTDFQELAHLRRLRYLRYLCLMGNPIARDKHYREFIVWCMPHLRVLDYRRITERERAVARKAFESSGGRLSELAASLTRYKSPVVGAAANAARALSFDPGAPMPTAGRRLTAEERAAISDAIDQSQSMEEIRRLEEQLKLGYVPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWH2</accession>
    <name>A8PWH2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731831.1">
        <property type="nucleotide sequence ID" value="XM_001731779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWH2"/>
    <dbReference type="STRING" id="425265.A8PWH2"/>
    <dbReference type="GeneID" id="5856136"/>
    <dbReference type="KEGG" id="mgl:MGL_1099"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1099"/>
    <dbReference type="InParanoid" id="A8PWH2"/>
    <dbReference type="OMA" id="WCLCESG"/>
    <dbReference type="OrthoDB" id="288703at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="750"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="845" mass="90991" checksum="C33031F3978D8CDA" modified="2008-01-15" version="1">MPKARPDVARRVQRARRRDPLRRPEHVDVPVPSAEEVVPVLTKLGMDASAPAIETGDKVWALASVATLLADDNRKQLRLLLSHKVVPRVLYALQSDTNLEVRREASGALRNLCLCGDDEILAEIANKRGVEIVLSVMKWAALGLQSHERRLERARAPLIEERERLMAKPLDQMNRKERRHMAKLAQGRLPDATAGATAEFGGESHDAFDMHAWGTDAPTSLQAMDSTAAQCLIETCESLVTCLSSLCELSEKISTRALHWSWHTDLSCATAPASSASLPSAFVGEGLSAWLCEALSLGTRACKAEDPELARLPECLPALISLGIACAQALWVLTDSADGGGTGELVRSLCGRYASTLPKGAAMPTPADERAALQRARHRLECLMQASSFVAPDAAPRAAILGAAACGTLVHVYAFLCTDADVQNEDESQDVQELSSFVQVRIFSRVMQVLKDAQPEMLREDTQSALEVCLELVADMGQAVGPDVSRAAWQPTSQLIPSPLMVSLLRLAAPSPESATENSVAATARRAIETRALAALNNLLWYLALHAPPVPSELPGEDDHDAWDRIHAWRAWAGTQCLEWASSGTISTTTAITSAHEALVSAWNDVFAIAAFWAGVEDVANAAQSSTSTPASMSLSSPDAHQLASSVANDGLAQVSTSIGCLWSIARMLEGQLPLVQPDSSEPTPVVTALMAAYYSAQDASVRVKVLGTMACLARSQHYKMTSSGSSGSGRHGAAALGNAEVPSSYMHVYTSVAEFWADVAGHVPDPETLAALLHAIVDTYADERAPWDSVYRATHLHEKLCSLMPRFMAMAKRVDRRADPAMYRAVQESVETMGAFLAYRQNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWP1</accession>
    <name>A8PWP1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1168</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731900.1">
        <property type="nucleotide sequence ID" value="XM_001731848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWP1"/>
    <dbReference type="SMR" id="A8PWP1"/>
    <dbReference type="FunCoup" id="A8PWP1">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWP1"/>
    <dbReference type="GeneID" id="5856205"/>
    <dbReference type="KEGG" id="mgl:MGL_1168"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1168"/>
    <dbReference type="InParanoid" id="A8PWP1"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="404" mass="43540" checksum="CB91C5AF1C2D56E5" modified="2008-01-15" version="1">MSTFGSTYRVSTFGESHCKAVGCIVDGIPPGLAVSEQDIQRQLTRRRPGQSSLTTPRDEKDKVEILSGTEKGVTLGTPVAMMVRNQDQRPHDYTDVKLDAIPRPSHADYTYLEKYNVKASSGGGRSSARETIGRVAAGALAEKYLTDVLGIEIVAFVSSVGHVGLSTYDADDDETPLRNDYLELLNNVTRDQVDRENVRCPDATTAEKMRARIMEAKEKNDSIGGTVTCVIRNVPVGLGEPSFDKMEAKLAHAMLSIPATKGFEIGSGFRGTCVPGSKHNDPFVGKPDGSLGTSTNWSGGIQGGITNGEHIYFRVAFKPPATISQEQNTARYDGEQAVLENRGRHDPCVVPRAVPIVESMAAIVIMDMFLAQSARKSAANKIDPAAVSALPNSMKKRKLPSSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWY7</accession>
    <name>A8PWY7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1263</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731995.1">
        <property type="nucleotide sequence ID" value="XM_001731943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWY7"/>
    <dbReference type="STRING" id="425265.A8PWY7"/>
    <dbReference type="GeneID" id="5856300"/>
    <dbReference type="KEGG" id="mgl:MGL_1263"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1263"/>
    <dbReference type="InParanoid" id="A8PWY7"/>
    <dbReference type="OMA" id="YKMGGED"/>
    <dbReference type="OrthoDB" id="2505961at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000535">
        <property type="entry name" value="Chromatin modification-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="377"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="213"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="296"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="430"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP44781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="468" mass="50913" checksum="293EF9905B6DCB99" modified="2008-01-15" version="1">MMPSEYAGMYGVPSGMQPGISGTLDSLHPFFSQARVPEAPLTEDDLALFMLLVTYSDALDALPMETTRIFSDLRELDAVLGVHLGSLAHRLNHLASVIENPDVSPGERLLVLKEAADEARAYKMGGEDKIRVAVNTCDMLASHTEYIESILRSLTSLSALAPYVRESRAQYKHLSDLSGFPNHGESLAGPSAVNPPVDMASASASYPFAPFPDVSSSRAPVERDSQSAVRAGKKRKVPPHSVSSQSSTRSSSETQRNNASNPHPKRREIASRHHNHEETDQGESSDEQSELFVTGNSADRLARTHHRARTRGTALPMEPVAPSKTTSGSATWSGRRVVDASVPVDHASQGDAPRTTSRSRISKASSAGSNRDDADDQRYCFCNNVSYGDMIGCDDDDCEREWFHLGCVGLSKPPQGTWYCDACLERRMQQSKNKTKRSARPTRAPTSGVPPATSDVPTSARRVASHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWY9</accession>
    <name>A8PWY9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731997.1">
        <property type="nucleotide sequence ID" value="XM_001731945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWY9"/>
    <dbReference type="FunCoup" id="A8PWY9">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWY9"/>
    <dbReference type="GeneID" id="5856302"/>
    <dbReference type="KEGG" id="mgl:MGL_1265"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1265"/>
    <dbReference type="InParanoid" id="A8PWY9"/>
    <dbReference type="OMA" id="SQMKGVC"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727990" description="30S ribosomal protein S12" evidence="4">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18529" checksum="709EBCE676B49442" modified="2008-01-15" version="1">MWRALRGIASGFVHTAAWARAPAMATMQVYPVRTLKTTPVWNVTLQQAMRGARRPHRPPVNRVPALEGCPFVKGVCTKIFTTKPKKPNSAIRKMARVRLTNGRTVTAYIPGEGHNLQEHSVVLMRGGRVQDVPGVRYTLVRGALDFGGVVGRTTSRSKYGAKKPKETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX36</accession>
    <name>A8PX36_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-phytase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731129.1">
        <property type="nucleotide sequence ID" value="XM_001731077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX36"/>
    <dbReference type="FunCoup" id="A8PX36">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX36"/>
    <dbReference type="GeneID" id="5855448"/>
    <dbReference type="KEGG" id="mgl:MGL_1312"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1312"/>
    <dbReference type="InParanoid" id="A8PX36"/>
    <dbReference type="OMA" id="FEVMECD"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="61107" checksum="ECDB80779D643435" modified="2008-01-15" version="1">MKYGAKPFLAQKDRLNTTRSNNDSSVEMRWLPWNAEEDAATSDDIFRNLGTTSPYHQAFDLFPETIEHQVLPPQCKIKSAHILHRHGSRYPAGPGGPSSLGRKIKLAQKTGQLKAHGDFEFLEHWEYDLGEDVLVHKGAQELFDSGVKYYYEYAKLLENYDKKPVIRTTSQSRMVDSARYWALGFFGWDMQDKVNIEVLTETFFQNNTLAPYMSCPNPFSPKVLKALAWRFKMLKKATDRINKHVKGITFSSSDVSNMISLCGYETVALGYSNFCKLFTKQDFEEYEYEQDLMHQSVFGFMSVTSKAWGVGWVTEFIHRLKHKAFDGPQTSQNSTLDHNPKYFPVHQPLYVDFTHDIVIESILTALNFKQLADELDGGRMQPNRRFRTSHVVPFGARLVFEVMECDENGDKSEYIRAKLNDAVVPLDGNQGCESRLDGLCRLDNYLSHLEKHAFQNSNFDFLCRLKIDENFDLKKLLDGGILSNDDLKQISKTPPGYHEHHKKSDDPLGFALNSKMTRHTRSGFVGRFAQILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX63</accession>
    <name>A8PX63_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Conserved oligomeric Golgi complex subunit 5 helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731156.1">
        <property type="nucleotide sequence ID" value="XM_001731104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX63"/>
    <dbReference type="STRING" id="425265.A8PX63"/>
    <dbReference type="GeneID" id="5855463"/>
    <dbReference type="KEGG" id="mgl:MGL_1339"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1339"/>
    <dbReference type="InParanoid" id="A8PX63"/>
    <dbReference type="OMA" id="MMVEYFE"/>
    <dbReference type="OrthoDB" id="3356019at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="779" mass="88218" checksum="1CDD450E7E2D928C" modified="2008-01-15" version="1">MTAHNGTCFCEQLTLSARKAIRGPLDTIQSEQARLKQLDHIQELLVHSKTVISVSNRLVEKMDAVAECDVMGCMQDPAALDHHAAQVVSASAFLEELFYMLDARDVSGTETSMAADAEQQELMKDVMHLLIIQPYASQANPMKSALREHIENLLLCGLRNLSPNLLGAALQAAFHLDILSSVVGNLLEDLTNVLVERTSSAFDLIAIGKELGETQPPIVSFHSVLPPYRARFLSPAANKSSEQLQRWTVAVWHRIRALIVDELAPIHAKVYMMERVLRLKQAHDTDLTFLDVVTRQLTCSPTDLLWTAFCSNFDALCSESIQESEFWKFMFVSSFPKLLHIFYELVSRVAMLTDQSSETRGEIPEPIRIFLKNRSQTYLQSVSERWDEGCQRVQMAMTLGSRNPQHYNADVQRFVQMLLTDLEECGFDRVLSSDIASMGTNLFKTLLSQIPSMTRKDENAFLLTVHQPTSSQTINISVGRTLKQLHAHLSHIESTDFPKIRELASAWRKSVLNVIRTNLLDPLLVSARYNLATVLTRIHRFRFDKSHNMNSDAMGAETSAYMMEFCGRMSFLRTKLLPFYVVPEDELHWASELASFALCTFLLHATLLRLPSDAEKLQLVTDMTTLELSLSQFLSDVSRSTNNRPLSLHDCDASFHAVRSFRTLLFEPLSSWKNPSNIREMWHIPDVILVQHLLSKSTTLPLPSDIRGMSKPAYVDWAISMSQVKTSLLSPRVESTVLQEIHQWLSKHGVILENTADEKDKEVFACLKVWDTFFALHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX93</accession>
    <name>A8PX93_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731186.1">
        <property type="nucleotide sequence ID" value="XM_001731134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX93"/>
    <dbReference type="STRING" id="425265.A8PX93"/>
    <dbReference type="GeneID" id="5855493"/>
    <dbReference type="KEGG" id="mgl:MGL_1369"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1369"/>
    <dbReference type="InParanoid" id="A8PX93"/>
    <dbReference type="OMA" id="AWHAETD"/>
    <dbReference type="OrthoDB" id="3346336at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="182" mass="20224" checksum="0F671218A41C89C6" modified="2008-01-15" version="1">MAATSLVQRIERVISQDGRDDPASRDACLAMVADATPLVSELKSMNRTAYEALAAERVHVESAQLALDKASLEYEALLLEHQELKAQIDAHLEVERLDHDVLSPDDLTQLATLGEEEQHAAHLARLQEILNERRKMETDAKSLDEQVRQLQAQSRLSHRTLVRLEQSVAALQASVQEQAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY38</accession>
    <name>A8PY38_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Leptomycin B resistance protein pmd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1584</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731401.1">
        <property type="nucleotide sequence ID" value="XM_001731349.1"/>
    </dbReference>
    <dbReference type="GeneID" id="5855708"/>
    <dbReference type="KEGG" id="mgl:MGL_1584"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1584"/>
    <dbReference type="InParanoid" id="A8PY38"/>
    <dbReference type="OMA" id="RANVMHQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="749"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="797"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="894"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="977"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="362"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="753"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1106"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1388" mass="151917" checksum="3825A72611635467" modified="2008-01-15" version="1">MKYVDLFRGLQPVEGLLLFVGTLASIAAGVPLPIIGLLFGKMVDGFNRQACASRSGMPTDPAERDDFLHQVSNHVVQIIIVAAINFVLIWIYTCSWSLLGERIVRRLREQYVRAVLSQDMAFFDVLPPGEISTRLSENLIAVQNGTSEKVGIFLSSVSYFLTSYIIAFVLLPALAGELVSLIPAFLIVSLVGAHFVSKFSAQMSSHLGNASGIATESLNNVRAVQAFEAQKPLCKLYNSHLHLVRRSGLFRALSAATMLGCLFFVAYSANALAFHSGSRMVTDRMRSNPDDASSTVGSVYTVIFLLLDASFVVGQIAPYLQTFSAAGGAGSQLLSTISQESPINALSDTGTMPPLSSEALGFHLRNVTLAYPARPDAKVLDNVDLDIEPGTRVGICGFSGSGKSTIVALLHRYYMPLEGQITLHDDTPIDELNVGWLRSQMGLVGQEPVLFDCTVLESIAHGLLGSSSHNDVQDAIRWLSRYAFDHAVIPKDWSQHCPSDLRPGLRRLQALCEEAAQLAHAHEFILQLPHGYLSRVGDAGRCLSGGQKQRIALARAIVKKPRILILDEATAALDSQSEMAVQTAFDRVSQNRTTIAIAHRLSTIKHYDKIVVMAHGKVMEQGTHAELLALNAHYASLVRAQSDYGENDVEQVSTTESTGEQKVAAVEDECQEDDDKQDVVDSAPLTSMALPLPTQPVVPPATMGDVEGIHPQEPEPMSVLKTEPDQMKSRRLSYSRSLVRLMRWALMKWPFAVAGFLASAVIGGAFSGEAVLFGHVIEALNPCKPAREVEHQSDLFALYFFVLAIIELFCYFVSGAAFGFVSEWLLLRIRKLMFRALVTQPLAWYERKDLSPATMIANLSADTSNLGGLTGTVVGTIFSILVNFVAGITLAHIVAWRIAVVILATVPILVTAGYMRLKVIADFQKRHETAYARSTAIAVEAASCIRTVAALGRERDVIQLFSYSLERPYRESMRHILMGNACLAISLSISYFIYGFAYWWGSKNVAEERFSQVAFFTVLPALLFSAQSSGQLLAFAPDFTKAQVSASNIFSMLDQANHPVDMPGYQWPDRRERRRLRQQRKHQHYLKDLESEKSLEPVGAHGPLAVSFDHVWFTYPGRDKPALRDVVLDIPAGSFAAFIGCSGSGKSTAMSLIESFYEPTSGTVRVGGCSTTHVPTKALREHMALVPQEAMLFHGSIEFNVALGLADPLSVEAVIEETHAHRQRQQTLSHACHMGSHQHASTKARVTKPDERILAACQAAKIHDAIAALPDQYRTNIGSGGSQLSGGQKQRVSIARALVRAPRLLLLDESTSAMDASSEKAFQETLSKLHSSRSCTIVAIAHRMRTIRTADVIFLFDQGRIVARGTHDELIKTCSRYQAMISHQSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYC1</accession>
    <name>A8PYC1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1633</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731450.1">
        <property type="nucleotide sequence ID" value="XM_001731398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYC1"/>
    <dbReference type="FunCoup" id="A8PYC1">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYC1"/>
    <dbReference type="GeneID" id="5855757"/>
    <dbReference type="KEGG" id="mgl:MGL_1633"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1633"/>
    <dbReference type="InParanoid" id="A8PYC1"/>
    <dbReference type="OMA" id="FDCTFQY"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="17712" checksum="D4A0111D6EB32841" modified="2008-01-15" version="1">MPITQTGHPGQDHSRDPCPWVILNDFGGAFAMGCIGGTIWHGIKGARNSPRGERMLSSVSAIKARAPVLGGNFGVWGGLFTTFDCSVKSVRQKEDPWNAIIAGFCTGSTLALRGGPKTAFGAGVMCGILLGVFEGVGVLMQRLLAENNKPIAPIIPDSPLAPAGGNASVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYJ1</accession>
    <name>A8PYJ1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="8">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731489.1">
        <property type="nucleotide sequence ID" value="XM_001731437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYJ1"/>
    <dbReference type="FunCoup" id="A8PYJ1">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYJ1"/>
    <dbReference type="GeneID" id="5855796"/>
    <dbReference type="KEGG" id="mgl:MGL_1672"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1672"/>
    <dbReference type="InParanoid" id="A8PYJ1"/>
    <dbReference type="OMA" id="AKCETWG"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 8" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="559" mass="63024" checksum="61C4BA3578602EB4" modified="2008-01-15" version="1">MSWSEAWSSYKRDKEEWIMGQSGSSIAYINLLSLTPLASYALWLCVNGRRKHNLLHSYVADFVMLVVPLMLACTTSSHDIVALLSCLSLPTVVLMLHEYRTRTKIGTHRVQASEDGRLPLKHANNRVTHTQLHADESNDASFRESFCVHADGSSTQEKKDLDSDTSIKRETLLSRNGSQSRSSSLHQADLQGKHLSCMSLSPLCFETCSQNSMSTPITNDLAQSDKFPSQKWSYVTIYRAYLMMLTTFCILAVDFPVFPRFLAKCETWGTSLMDLGVGSFAFSHGLVSLRSKRSSFSRLLRRTLPLVLLGAVRVLTVKRTEYPEHVSEYGVHWNFFFTMGLVLPFIDVSQQIWRPGFAPFGLYSLGIALVHESVLAWTPLGTFAISDARNPLSWVSLNKEGLVSLPGYVVIALAGLDIAHIMADTRRRDKLERDLCIRSFCLWLGVWIVRCLGFQISRRLANFPYTLWCAAFNVSLLLGFKVLERVFYDDSFPPVPRLFDLINRHSLILFLISNVLTGLINLLVPTMYTSVPVSMILLFLYMAIVCAVAPVWVYIAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZN9</accession>
    <name>A8PZN9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730937.1">
        <property type="nucleotide sequence ID" value="XM_001730885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZN9"/>
    <dbReference type="STRING" id="425265.A8PZN9"/>
    <dbReference type="GeneID" id="5855244"/>
    <dbReference type="KEGG" id="mgl:MGL_1936"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1936"/>
    <dbReference type="InParanoid" id="A8PZN9"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="31"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="229" mass="25353" checksum="8AABD03DC9340516" modified="2008-01-15" version="1">MYGYPAYASLPPSHASAGIYGVPPVQQELSNPAVFESMYRGQLAQLTFNSKPIITNLTLIAQEHVHRMSTIVAKLVDAHIMMAPPPHRLPALYLMDSICKNVGSPYTELWAPRAAVLFMESYRIVDQPTRRRMEELLATWRDAGPGGRPMLGDTTQQTIERSLYGSQSAPVKSSVGPSKAQVIANIERLMALSTKNLSHQPSSTVAQEQLTCCVSSRTRSSIRIPRRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0R0</accession>
    <name>A8Q0R0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2069</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731070.1">
        <property type="nucleotide sequence ID" value="XM_001731018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0R0"/>
    <dbReference type="FunCoup" id="A8Q0R0">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0R0"/>
    <dbReference type="GeneID" id="5855377"/>
    <dbReference type="KEGG" id="mgl:MGL_2069"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2069"/>
    <dbReference type="InParanoid" id="A8Q0R0"/>
    <dbReference type="OMA" id="ACELEWL"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="297"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="684" mass="76591" checksum="B793FA606CA4C36B" modified="2008-01-15" version="1">MNAMEVMDPVMDAGMAYPQEMIPEKERIEPLPTDAAGASHFAELTWRDVCWVMDRLLACELEWLRGTSLVQTVYTCTFFHKHVLAGTSAYVHWSHSVLSAYVLAVVKTCALQWYELARHHVLDQEDYCSETGGTPFPDAVEPRTIAAQLSEADECVRRVYSHVGEPTAAECISLRLLFRQHWLLCVESLTSDEPSGLDASMHLDECLRIWHAIAQSQCPILDTAMRTAPRHLHSYFDVTLSRALSSHFPLRPVALPDVAHVCAGWHNLMTKHMSIPLRLLASDDVLAWQSLLVCMSLSFQQDHGAPEPLIRSLIPTLLANGSTAMGGTRDLEHLAACLIEAWHPISVQDLQVRLEWHQAPSSSSSLSSVGASAGLGTVSSMLGSFLGRLASCVAQSLAIFVQNRSRQKRSFGKAYTVWMSLLDSATSLNPRVCAVLPAVPPDALVAPVQYMLLVHMEQVIGSGFDLELYDVRERACMYWVLAHLFEEASALGAVHNEWKGSASPGSTWQCYAHSARAQRDLCYAHAILYARTFGPDLSRAQAAFSRRLKWLRRPAWCSQARLHLVTSSEPFDLNLFWASYARWHSDTLSESQWIEPLLELLETSSHHAKQTLELRASDPSALLCRRERRTLDQHVLDTSTALETWVRTHRCAPTPDTWIPSMHPWYATLRSLSQQNEPLSRGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q106</accession>
    <name>A8Q106_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731109.1">
        <property type="nucleotide sequence ID" value="XM_001731057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q106"/>
    <dbReference type="STRING" id="425265.A8Q106"/>
    <dbReference type="GeneID" id="5855416"/>
    <dbReference type="KEGG" id="mgl:MGL_2108"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2108"/>
    <dbReference type="InParanoid" id="A8Q106"/>
    <dbReference type="OMA" id="CAYERYS"/>
    <dbReference type="OrthoDB" id="3353457at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="277" mass="30954" checksum="880B43A7EBD7AA48" modified="2008-01-15" version="1">MEWNVHERQQGSVAMFDAHIRIGGFRGSEQELTECPKHAKLTELPRAAFLSLHVTKQASGYFQNVWIWTADHELDKGAPEQLNVLTDRGVLIESKGPTWMYGTASEHALLYQYSLKNASNVLLAMIQTESPYFQGHEFEPASQSALTHPAYPDPDCSRIFAQGTNALSCAYERYSEDRALGLHLAGCSDVFVLGSGQYSFFNSYKQTALAGHACQRRLCTIDHSDGNVWLLNTATVGTQTLISIDGYDYLSEQPHREGFCSTLTLYAIRRKGQSYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q162</accession>
    <name>A8Q162_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730741.1">
        <property type="nucleotide sequence ID" value="XM_001730689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q162"/>
    <dbReference type="STRING" id="425265.A8Q162"/>
    <dbReference type="GeneID" id="5855048"/>
    <dbReference type="KEGG" id="mgl:MGL_1740"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1740"/>
    <dbReference type="InParanoid" id="A8Q162"/>
    <dbReference type="OMA" id="PAHECIS"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="137"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="299" mass="33296" checksum="1A171D3E0EF25B7F" modified="2008-01-15" version="1">MPANPNTHIPAGTPYFALSLSHRPPNIELPTPCEVLRDTLLKRYDVLDMRFAVAFGSLTQDDASILGPARSLLDWNERYKFCPACGSALYSAWSGHKRICSSLLSTLAKPSMFVQLSGQVPAHECISWTSMQNYTYPRTDPVVLVGVVNATNDKILLGRKKGWPNGFYSCIAGFVEQGETIEDAARREAMEETGLDIGHVTYQCSQPWPFPAQLMFGMLAHVKAPDAHIRLDLDNELEEAFFASRSDVLSILENRHNKEGNGFRRHGHTVTVPGRRAMAHMLLSKWASKHVEGSEQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1B4</accession>
    <name>A8Q1B4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_1762</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730763.1">
        <property type="nucleotide sequence ID" value="XM_001730711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1B4"/>
    <dbReference type="FunCoup" id="A8Q1B4">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1B4"/>
    <dbReference type="GeneID" id="5855070"/>
    <dbReference type="KEGG" id="mgl:MGL_1762"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1762"/>
    <dbReference type="InParanoid" id="A8Q1B4"/>
    <dbReference type="OMA" id="VYCWKCI"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038074">
        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="30"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP43549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="427" mass="49011" checksum="1ECC759CE366881B" modified="2008-01-15" version="1">MDVLANIDPTSSDGSAADPFRPSFFELIAQKQLSDLLKPAIRYVLTVLAQHYPRYLLRIVNRFDELYAVLMLAVERHYLRTWNASFTEHFYGLRRRRRPAVSTKRLDASVPPHKLHATRQLRDREVNVSLLFLVGLPYLEAKLSDYWERLGGGVVIEGDSGDDLFADEETVRLERSVSRQEAPAQRIRSRLKMLFRRGFPLVQVGLQLWMLAYHIKYLFGITPYWRPWLAAMRVDVRRAMGNETPLRLGAASKRLPQFSRFPLLFMLRSLQKGGAHILDALKYALPASIFFFKFLEWWYSPNNRRRGDDDESKSRKVLGPPVVSHPSSSGVLENPHESYRDPKVLKTKNQTPYVTDADDEIIVDIPSLLHNSCPLCGAMPIQNPCALPTGFAFCYRCATDYVDKWHVCPVTQIDLPGGIEQIRRVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1F3</accession>
    <name>A8Q1F3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730780.1">
        <property type="nucleotide sequence ID" value="XM_001730728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1F3"/>
    <dbReference type="STRING" id="425265.A8Q1F3"/>
    <dbReference type="GeneID" id="5855087"/>
    <dbReference type="KEGG" id="mgl:MGL_1779"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1779"/>
    <dbReference type="InParanoid" id="A8Q1F3"/>
    <dbReference type="OMA" id="MEDAYIK"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="25"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="363" mass="40159" checksum="D8C79849749F352D" modified="2008-01-15" version="1">MERFPLLPFAREARIDAISLESLEVSHDKTHERVAHQVLSSKVLAAELAACIRSLIPLIMPASDIPASLDTAHSNDPTPKSDSKAHAHAPEETSKHETKAKETPRSVSATLSSRPRSTKTRSETGAAAAADEYESDDGMGNTDMTWDRANLDAMVASGSDTESDSDSDSQDHARKKRPRDSDDDGDDDIETDHQDAFLPSLNTGFIPAADGDDWSDAEADYADTGGKGPAKSQRKNRRGQRERRAIWEKKYGRHANHLKLREKEPRKATKRTPRDSVREVESRRDTRTTHHDLVSTPSHARAKREERTRTKDESQPGMQAARAASSAHSHHVPPAVHPSWEAKQRAKEAQQTAKPQGTKIVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1Q0</accession>
    <name>A8Q1Q0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_1821</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730822.1">
        <property type="nucleotide sequence ID" value="XM_001730770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1Q0"/>
    <dbReference type="FunCoup" id="A8Q1Q0">
        <property type="interactions" value="398"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1Q0"/>
    <dbReference type="GeneID" id="5855129"/>
    <dbReference type="KEGG" id="mgl:MGL_1821"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1821"/>
    <dbReference type="InParanoid" id="A8Q1Q0"/>
    <dbReference type="OMA" id="ENYETKW"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000016">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="3"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="67"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="284"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP43608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="392" mass="44246" checksum="8D7B2AE8F6974BE5" modified="2008-01-15" version="1">MTLILPFLDLELKYYDLGIENRDKTDDKVTVESAEAIKQYKVGVKCATITPDEARVKEFNLKKMWLSPNGTIRNILGGTVFREPIILEKIPRPVPGWTKPICIGRHAFGDQYRCQNFVAPGAGKLTISFTPTDPNGEKISMDVFDFPENGGVAMAMYNTKDSITGFAHSCFRVAIDKKMPLYMSTKNTILKKYDGMFKDVFQDLYDKTYKPEFEKLGIWYEHRLIDDMVAQAIKGNGGFVWACKNYDGDVQSDVLAQGFGSLGMMTSELITPDGDMIESEAAHGTVTRHYREHQKGNETSTNSVASIYAWTRGLIFRGKVDQNNDLIAFARTLEDACVHSIDVDGVMTKDLALSIHGKNMKREHYVNTFEFLDHIKSVLMKKLEEQGILSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1R6</accession>
    <name>A8Q1R6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730829.1">
        <property type="nucleotide sequence ID" value="XM_001730777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1R6"/>
    <dbReference type="FunCoup" id="A8Q1R6">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1R6"/>
    <dbReference type="GeneID" id="5855136"/>
    <dbReference type="KEGG" id="mgl:MGL_1828"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1828"/>
    <dbReference type="InParanoid" id="A8Q1R6"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="254" mass="28783" checksum="8FF78C3BFB001734" modified="2008-01-15" version="1">MENYMTAQRNQVFSSVCALVYVVDVVGTDVDGGSDASDWETDLRYFRDSLSALQTHTPDAEVFCLLHKMDLIEPSRRKNIYMNRVADLRKKAREVLNEHASSSPHAAHAIHLRCYATSIWDATLYKAWSNIVHTIVPDVRHFEASLSELADMCSATEVVLFEKATFLVMSHYSRLDANETDATKHSKMMDTSSVVRIDDPQDSKEVLLAGLSSSMLPHSENMNDTAERHVVMSDDRFERVSELVKQFKLSCLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1T3</accession>
    <name>A8Q1T3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730836.1">
        <property type="nucleotide sequence ID" value="XM_001730784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1T3"/>
    <dbReference type="GeneID" id="5855143"/>
    <dbReference type="KEGG" id="mgl:MGL_1835"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1835"/>
    <dbReference type="InParanoid" id="A8Q1T3"/>
    <dbReference type="OMA" id="TWDLWSY"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7137" evidence="1">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="179" mass="19050" checksum="123A557AF133CD38" modified="2008-01-15" version="1">MLKLPAGGLSITEPAQTAQASYYKIAPHETITFGWEFTSLTATPSRLYVVASCSKNGNTYPIAPSPSGIPGDAKSVTWYPYGYRMDAQKHGGPDLVADKYRLIIYDDKGPTGVAKGGEFQANNMAEFSMYFPKKYTPLSEWTCNSCNGASRSSPPLPSSALLITLGALAFAAAGGFACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1U6</accession>
    <name>A8Q1U6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730842.1">
        <property type="nucleotide sequence ID" value="XM_001730790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1U6"/>
    <dbReference type="STRING" id="425265.A8Q1U6"/>
    <dbReference type="GeneID" id="5855149"/>
    <dbReference type="KEGG" id="mgl:MGL_1841"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1841"/>
    <dbReference type="InParanoid" id="A8Q1U6"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="119" mass="13570" checksum="4344D277E8E47C5B" modified="2008-01-15" version="1">MPPSSTTEQARQIRHKRMSLFARTTSKDDEVWHGYERIVGFDTMPDALDTVSGNASYTLQVKAKGYARTKHTRTFMCAVDATESSERALEWIMENLVDDGDELVAARVIDWDQDRTFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q226</accession>
    <name>A8Q226_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730877.1">
        <property type="nucleotide sequence ID" value="XM_001730825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q226"/>
    <dbReference type="FunCoup" id="A8Q226">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q226"/>
    <dbReference type="GeneID" id="5855184"/>
    <dbReference type="KEGG" id="mgl:MGL_1876"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1876"/>
    <dbReference type="InParanoid" id="A8Q226"/>
    <dbReference type="OMA" id="NGRITMH"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728039" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="76"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="231" mass="25999" checksum="1CAFFAA3709E5A00" modified="2008-01-15" version="1">MRIVCLVVGLLVLSAQILANPISGMIKTDPHNSMYAHAEPMDDIVHRMVSEARAHDIPLGKDLHSLGKVQSNAWSWEWCDDVDAEGYLVRVDSVQLQPDPPVMGRNLTFHGAGSLSGRVAQGSYVDVNVYLGFLRLYAERMDLCDVLRENHVEVQCPMEPGQYNITHVIEMPKTRVPPIPFRFRVLGISQDKQTIACINGRITMHNAILSWSSYPMHLLRSIGRVIWSPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q241</accession>
    <name>A8Q241_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730672.1">
        <property type="nucleotide sequence ID" value="XM_001730620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q241"/>
    <dbReference type="STRING" id="425265.A8Q241"/>
    <dbReference type="GeneID" id="5855042"/>
    <dbReference type="KEGG" id="mgl:MGL_2126"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2126"/>
    <dbReference type="InParanoid" id="A8Q241"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="893" mass="96523" checksum="1829EE13FDD131D3" modified="2008-01-15" version="1" fragment="single">MADAVTKNPRSNDLAHVYLEHVSRTLSATAEHMPNADFDESMQVQGQWPMADELAYTVVEGLLKIALCMPTMRSDMLTALNTLVNGLCSQLMSHGTDEQVLRLALRCVPQMHGVARALQDVAFVWESSTVTSLSHALSRLVSGADMVARLDRLLVALPEQQEAALQCQAVAAQRSRGETSMDLALTARTELADVRDQLLEQYMVLGTPLSGQLIAWCGMSAIASILSQAAIGTGQAAAIPNDTPAYAFTWQQMVKGTLPKPLYVPAMARTTYTMVANACGAMEVGTPLHAELYMSEQLCTALKLQVLATATNTDDATFVLDTLCDVLSERAPMQDMAVQRTALESAAVLGMARPTLSLKLLYHIRRWVQESLPFTKESAAPGMPAKVEPLPVTALSPLTSVTALSMAACIRGSGQDEAAASTTYTMLNYVSREAEPASINATLAVITRLAHHLRTPSFTALVISLLLQRTEGHGHLPISILFSHLVLLAITAPRSSFVNVCTSLADAMRRALAAGDMAQFQSMQQVCLQLMRQLTPQAEALGRQADAVAKEPVAEAGAKTDGAPCLRKETVLPEMLALVIEAGMRTHGGRANASKAVQELTHVLAALVAHDDMHVHWKPSTELVYLFRSAWIVMALTAAAPQSALTAPMPHGDALNIIALKTPTLIPTSARNYLDDDIDTYTVMKHDTLGVTPESLRQALSPIIGARVLDPRALSLARLAFVYAVLQVEWRRAACGRPSMALCYFAHAGVAASSVLAPLRAVAERTFSAFLVHVAERTESHTADECLANEARNILVATCHLRTAVREEAHAYLERLVPAFPWLFARSDVVATMLELTSLVGRGCDCELTNAFLPQYTDTSTLAGISIDLSDQYAERRTLLDQVLGRVRDILAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q248</accession>
    <name>A8Q248_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730679.1">
        <property type="nucleotide sequence ID" value="XM_001730627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q248"/>
    <dbReference type="STRING" id="425265.A8Q248"/>
    <dbReference type="GeneID" id="5854995"/>
    <dbReference type="KEGG" id="mgl:MGL_2133"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2133"/>
    <dbReference type="InParanoid" id="A8Q248"/>
    <dbReference type="OMA" id="NNFSTMW"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="230"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="395"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="75336" checksum="E72E3D6BDCC05DE6" modified="2008-01-15" version="1">MDPIVQKLEAGMLKLGQSMRQTFLAIIQASQTDPESSYLCDIGASEASLAILPKDLANKFPTLAVRVHMLIKYLQDPTHSSKNHSEYTKEQSRFEGLAHQFIDTMTFLKHEVLDNQRILLSSRSESPLSMEDLGSEGVHATDCSVSPVLSSPAPRNDSAKRPGMRRASTSEIFSSLLRFSPVSINEGKIELAGLTSMSSDHRVPIVEPDSPVSDTFLGSDIPPGDIVFSPQGTVKGGTLEALVVQLTRHDTFDTKYTMAFLTTYTSFTTSERLMELLIDRFHLHMPVGLDEGRLKQWDELKKIPVQLRTVNVMRLWLEYHCDGLKDEKALDLIEAFANHALIHRPVKGMRGMLLRLIDRRRQGLETIPRRFSRPKSMPQPLLPEDMVNPSLLGIDPIELARQLTSMESDLFFRIRPLECMNKAWTGPDASQNAGGIVDVISFHNRITDWVSNVILMGETAEQRAILMSHFIAIAQECRLLNNFSTMWAIFSALNCASIFRLNASWSLLNNKSMGILAELNQITQASRNYHYYRELLCRISPPCVPFFGLYTKDLTFIEDGNPDQMYSDTRLINFCKRFLITDVIVEIRRFQSTPYSLARVPALIDFLEKQMQSGWDDDERYDRSLLLEPRLSSTHSKPPVRQNLNALDTEADEHLSNLLRQNGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q253</accession>
    <name>A8Q253_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chitin synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730684.1">
        <property type="nucleotide sequence ID" value="XM_001730632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q253"/>
    <dbReference type="STRING" id="425265.A8Q253"/>
    <dbReference type="GeneID" id="5854980"/>
    <dbReference type="KEGG" id="mgl:MGL_2138"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2138"/>
    <dbReference type="InParanoid" id="A8Q253"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="56075" checksum="CCBA8939135C7E58" modified="2008-01-15" version="1">MMFQPSAVCKTVVPDTFRVLRSQRRRWINSTVHNLFELIQVRDLCGTFCFSMRFVVFMDLVGTMVLPAAIAFTVFVVVQAILTPFQNKGKDDGEKKEFPTMPLVLLALILGLPGVLIVITSRRFMYVIWMLVYLISLPIWNLILPAYSYWHMDDFSWGATRMVQGEKKGESHGSAEGEFDASDIVMKRYVEYERERRWRSGMESRDAPSESGGMSTLGSLNEEKALPPPGADERSARHRLDSVPLLELPAPLGSDSRQRAGTMSPPVPGGKGPNGARSSPAGTTSPPNPWTSSGALTQTGPAPLTAQRVNPSPNPSASAMARQHLFGATPTSAAHASMPVRPPGTISPPPRPSNIGASGPVSPPSFRGNVSPPPMFPAGPLSPVNTRPTPPVRPVAPSPSGWNAASQPARPANTQAYPSPPSSGTQPGSAPTLAGFQPLSPPSASRPPPLRAPSNAQQMRGDVRRVSLVDDGPVATSGGSMRQVVRGARRQSSINSGAPNSASTASPPSNSNPFSRPANPFSPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2I4</accession>
    <name>A8Q2I4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730403.1">
        <property type="nucleotide sequence ID" value="XM_001730351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2I4"/>
    <dbReference type="STRING" id="425265.A8Q2I4"/>
    <dbReference type="GeneID" id="5854705"/>
    <dbReference type="KEGG" id="mgl:MGL_2198"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2198"/>
    <dbReference type="InParanoid" id="A8Q2I4"/>
    <dbReference type="OMA" id="MRRANSY"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="305"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="305"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="436"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="646"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="800"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="810"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="857"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="892"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="936"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="980"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1165" mass="123616" checksum="7A514A4C5B460A78" modified="2008-01-15" version="1">MFYFAGMPPVSTSAPTTSGVAAGAPDGPGPRDDIACHFVAPGTMPPPPATMQGNLEADVTPFMTPMRHSLSETTVDSASISPTLLRQIQAGSMPNVSSPLAVHSVLAPPSSDGKRRRMSASQFGSPPNANMATMDPSTSSPFSNAMMSHAASPAAAAAAAHQNNLFFQHAMLPFGMPDSPSSSPSVDTSMQALSMTPNNNLSPLTHRTLRAASSSAASPTGAFRGGPMTATASVQESPLMRRANSYGSVGSPWGSHDNMYMFGMAPGISPVAGPAPMGPPISAPVQMQRNYSSPQPRAMRERGTRQSSTDVWPDDVEVAFWEALRLIPKLGRRKVLVHGKPCGRNELIADYIERKTGKTRSRKQVSSHIQVLKNVKRNDLEFQQLISEPTHEEDYYTPAGGMMYAHALSEYSVGLLGFSLTTTDPTVSPMAASSAAMSPSVSSPLPPTHSPAQSPASGMISKALDNLHVSNSPRLDDNGRTLSPRYPSAPAPPSASMSASLARRKKVPLVDFDPMPVLVPTAFSMWTSSTTTDERHLYTNLDTLSMSRTLQSGGELPVLSSTDPIVTSFRFPQLVDMFKRVACPFVHVHVPMSLPRADASAAQYNRLGVALSIASTRNTRLCSVLSIYSHGKCVLSMVDHLEPPRPLAPARSDSVRSVLHEDPSEPSNQRSPAPSNDARFAWAYQVPFASDFWADFLSRNHPMHIYGPGGVEPMTSYCKEPSERASVGMAVSGLAFIQELVVPQSDGVSTITPRSIVSVDSPGSQVGDIIGVVAWDFECVEALGCEPGVPIVSVISHTSSALNHPTTPHRPSSAALSSESRAATTTESALSSSPTSHRSSEKGLLGLEIHASSRPCPQSGPQQQSLKQSQDPSSSSSTSTLPDNAVSSSNTDHQHRETPSSTPQKEKTDEDSAQMQSKPDSSLLRANTPPPPPTLIRTQASPFTSSSPVKVHDESEPNKKVSPTPKPPMLSSSGAISSLQRDEHRSWAPSEAEKLAAAPPPAQSPFSNDSSLFTSSSYTSGLNLSNVFRQKHVTPHGMTTTLSPAASHADLFSPVGPSPPPSSSSSSLLAPNVSIPGSVSSLPMPVRSNSMSMLEEHDDDVFQPFSTQVSSPSLLSDSIPSYLDPTDVGGRFGLSTHVQWNAQQDLMDAFLNSSMMESSSGISPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2Q2</accession>
    <name>A8Q2Q2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730423.1">
        <property type="nucleotide sequence ID" value="XM_001730371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2Q2"/>
    <dbReference type="STRING" id="425265.A8Q2Q2"/>
    <dbReference type="GeneID" id="5854730"/>
    <dbReference type="KEGG" id="mgl:MGL_2219"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2219"/>
    <dbReference type="InParanoid" id="A8Q2Q2"/>
    <dbReference type="OMA" id="PPYPPWM"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727173" description="FAS1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="28"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="226"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="379"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="533"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="915" mass="101131" checksum="4E58E8BB59C8AEC0" modified="2008-01-15" version="1">MRGWQWGAWLSALVVGALANVSESSTQDVNLVDIISTYPELSTFIHYLQRARLIPSLNRMQEKSDVSSGMTIFAPTNAAFESFWRHGDLGNKSVVSEQEQHLPDNIQAELRQQLLYHVLNYTLLDGNDANLFLETLHFPSRKRLFEPTRPGTVPQKPQDPPHPGAEDRGGLLGGYGQMLRVVRAENGSITHVGMDHRGMHGARIVHVDRRSRHGIVYLIDRVISLPPSLDVFLREQSVSTLFRHIPNDTLRTLATTAHLTVFLPTDAAWHQLDPLEKKYLLGSSPEALQDRLRVFGWHASSTGLGDGRVAYASELLAAPQTNLTTILGGDVHVRTQAGPTPGSPRSLSLDGMSIVQQDILTENGVVHIVDGMHMPFGDLGMTAEKYLLALNATEFVALMKHAGLGDYITQDPHEARRPATPRGPFTFLVPPNSALRNWVHQHVAQPISKHSSSMQRLRDMLLYHILPDHQRTLTNETLLTTQLYPTGLLGAPQRIPVILSDNKTLTFGHARVTHGPVHAHTATMYLLSDIARVPTDPVHTAARASLSTYVQALSKAHLDSSIRKAPLMTYLAPINEAFENMGLAAKYLLHTSNADLSHVIASFALPGALYLSSLEANWTRVVTGDGSFVWLRRDEAGIAVRTPTTGATLMQTTQTDLITDTGVVHAVSDVQLPPSVPMTLSKLARGAPTQKMLSLIHAAGFDWVWNSSLTIQADRKCKQQKLIVLLPEDRAFAKLNISLYEANPESLRALVALHILVMDECHSRKRTDEHLPLPLFDEMVHSTMLDKRLGGSSAFGRLAFRRTSASSKNQLGYMVGIKGARSTVGKEHAANVLDLGHAVLHETLADGHVVPGGVLTIDTVLEPFEPGWLLRWNWTWKMCLLLVLVSGACVTRAYTRHRRWGYTRVQSDAFEGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2Q9</accession>
    <name>A8Q2Q9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730425.1">
        <property type="nucleotide sequence ID" value="XM_001730373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2Q9"/>
    <dbReference type="GeneID" id="5854732"/>
    <dbReference type="KEGG" id="mgl:MGL_2221"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2221"/>
    <dbReference type="InParanoid" id="A8Q2Q9"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="78" mass="8907" checksum="5C6822EEE4C6C34D" modified="2008-01-15" version="1">MNETDALETMTRLRDASSIDSVEKLYAFHGNKSVGDGWQLYNAAKEFKRQGLGTHTRTWRFSSVNADYAVRDRCAFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2W2</accession>
    <name>A8Q2W2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Origin recognition complex subunit 3 winged helix C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730456.1">
        <property type="nucleotide sequence ID" value="XM_001730404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2W2"/>
    <dbReference type="STRING" id="425265.A8Q2W2"/>
    <dbReference type="GeneID" id="5854763"/>
    <dbReference type="KEGG" id="mgl:MGL_2252"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2252"/>
    <dbReference type="InParanoid" id="A8Q2W2"/>
    <dbReference type="OMA" id="RETYWER"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="2">
        <location>
            <begin position="578"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="744" mass="82358" checksum="6C7F609BE584EC34" modified="2008-01-15" version="1">MYERDHIPAQQRSKAFETTWECALKRMRALVHKLYEPSVARLRERLSVGRSLLVPATILDLSGSATYEALPAWLSDELAQSERITVHLMPAHCANLAHALAAFVAQIIQYIPSTPELLRMSQGYEPNDLALIPALFSAADRALPQIVLLVHEVQTFPVAVMNDALAAILTWSELTCPAPSLHILLSYTAPLPALPRVKKLSDVNQSGPSSAASTTAHVSAGSEADIATEAWHTYLLTERVRSCLDVSTVSFPDKSTFWEDVLCVFFAEPVSGLWLGRSLFELVRRRFWHTSPSWDAAAQCIRLSYVEHFRARPLSAFVHEFPDIDALHQHWTAEMLAHMRVTLFSSYMHTQRMSSRMRMLAHDDRALVSALSGLQSDMVVCMTHRAVALATVREMLRLLHMTGVYGTKLGLSACTALALEWLPPYTDWDASRTAVNALTATTPTSQQVQALLNHLCSTLNQAQVTQLVDGLRQRLNDIAASLDVGAAAVVRMICSDLELAHQQQRPLKRVRSELGAIAMTMAAETDASDASDAGRAVLAEWVTSTWQKATEAPSDLGLAIWTYDFAEPVSCALDGAARATVLLALDAPTDMLASMTAAACTASGQREQSEQAPWLELDDHISEVDELRRVHRDLNCASIPDVCRLYALYKDTSKFINLADWYDAFAQSLEGDERRREQQRRQRDGQEAPPCTDASDSVVTSPQMRFSLAVNELAYMGLLGPSSRKVEHLSRLVWDLPVNGMDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q374</accession>
    <name>A8Q374_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic Fe-S cluster assembly factor NAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cytosolic Fe-S cluster assembly factor nar1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nuclear architecture-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2327</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730531.1">
        <property type="nucleotide sequence ID" value="XM_001730479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q374"/>
    <dbReference type="FunCoup" id="A8Q374">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q374"/>
    <dbReference type="GeneID" id="5854838"/>
    <dbReference type="KEGG" id="mgl:MGL_2327"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2327"/>
    <dbReference type="InParanoid" id="A8Q374"/>
    <dbReference type="OMA" id="GYLHHVL"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000042">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="11">
        <location>
            <begin position="108"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="595" mass="65276" checksum="6E4C106FDC07F75E" modified="2008-01-15" version="1">MAFSGALTLTDLNDYLGPSQACIKPVEAPTTTASSNAPESTIALEGGVYVEAPVNAPRARTQLETAQISLNDCLACSGCVTSAESVLIGVQSIDEIRNELAQKRERIFIATISSQTIASLQARWGMQPPAVWTRVCAALKQLGFDQVHDLSLARHMSLYETVREFRLRREARMRGTKDAPTLPMVASACPGWVCYAEKAHGELLPYVATTKSPQQLAGILAKRFWGPQQKGVDISQDSAPYVYHVSVMPCYDKKLEAVRQDNEQTSQTKDVDCVLTTGELHDLIVGVDVHANAETEPRESESERASDKQMDEASDAWKHVMSGSSSGSASEQNEARITPRPQVATEFCDPAHVPAHQEPGSSSGGYIFAVLLDAYMSWIRSHPDTSQPTVELHILRSTDYTDYTLRAPDGTTLFKGATCYGFRNIQNVVRKLQRETGARSTRGRGRMRSVARPSPQDTHPYDYIEVMACPGGCVNGGGQLRPPATWALDTSSLSMAALPDAQQASEASPVQGWQGTDRRWVQHVENLYWGDDMKRGATVDSAQSLLERAAHGPLRSWLDAWDRQASDALSLFKHDDLHTKFNAVESNPQGLTVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q388</accession>
    <name>A8Q388_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2336</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730540.1">
        <property type="nucleotide sequence ID" value="XM_001730488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q388"/>
    <dbReference type="FunCoup" id="A8Q388">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q388"/>
    <dbReference type="GeneID" id="5854847"/>
    <dbReference type="KEGG" id="mgl:MGL_2336"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2336"/>
    <dbReference type="InParanoid" id="A8Q388"/>
    <dbReference type="OMA" id="SERMERC"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF242">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="86"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="386" mass="43463" checksum="32222BD7D28EBDFD" modified="2008-01-15" version="1">MVVPVDKVDRIHHEWTLRFFGLLVLVNFFRLLAYYEVYSTDKLRPQVKDDVKVTKIRVPSRDKGRYITAYVYEPVNMPAGPRPVNVNIHGSGFCINAFYGNSRWFNYCVASNLQCYVIDSDYRKAPEYPFPLAIYDCQDVINWVFTQHEKFDLDRVSMTGFSAGGNLALATTNHFGPDKIKAVTSFYAPLDGSTSNASVGDSGVEKGPFRSGIIMDNFVFSVFFAAYVTLQCDPGDPRISVMNLPLERLPDHILFVAGDADTLYPESVRFYQHVMKNGRFSQQRHCRFLSVPNEAHAFDEQPKCPESVAWRDKAFAQTIDLIRSSWTLDALSSVHSPRKMHSSKESPSIDGTASDDLSNPANQTITTMSQPRGPDGELIPAPSIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3I2</accession>
    <name>A8Q3I2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_2410</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730614.1">
        <property type="nucleotide sequence ID" value="XM_001730562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3I2"/>
    <dbReference type="FunCoup" id="A8Q3I2">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3I2"/>
    <dbReference type="GeneID" id="5854921"/>
    <dbReference type="KEGG" id="mgl:MGL_2410"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2410"/>
    <dbReference type="InParanoid" id="A8Q3I2"/>
    <dbReference type="OMA" id="MYLFAYW"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP43400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="386" mass="45010" checksum="B6D6D05524201165" modified="2008-01-15" version="1">MASHVYQDAFPTPRAFIGYGGLMLVEFVLAWIMPGYMQEGLPVPSLNYKTLMYKCNALGCLYSTLIIAAALHVSGVFRLTQIIEHFGEYMTVSMIAGFAVSFATYFHAVFTHTTHRMSGNFMYDFFMGAALNPRIGPIDLKMWAEVRIPWILLFLISVSGACQQYEQYGYVTPNMAFMVLATGLYINACAKGEECIPQTWDMFHEKWGFMVIFWNFAGVPFTYCYSIVYMAAHPPEYYRFSTPTYIFMFSLLLFAHFVFDSSMAQKSRFRMQLQGTLKVRWSFPQWPWSTLKDPRYLQTEHGNALLIDGWWQFLRKPNYTADWTQAFLWGAIAGTRSVIPYYYSLFFLAVLTHRCGRDFERCARKYGKDWEKYCQIVPYRFIPFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3J3</accession>
    <name>A8Q3J3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730625.1">
        <property type="nucleotide sequence ID" value="XM_001730573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3J3"/>
    <dbReference type="GeneID" id="5854932"/>
    <dbReference type="KEGG" id="mgl:MGL_2421"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2421"/>
    <dbReference type="InParanoid" id="A8Q3J3"/>
    <dbReference type="OMA" id="VEWIMRY"/>
    <dbReference type="OrthoDB" id="3352386at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="490" mass="56842" checksum="3C35F02C939A3B5B" modified="2008-01-15" version="1">MRKLTRQHPSMTAGALLDWYSERVKESRNRIPSGSGDSPAAVEWIMRYAARRQDIYTLRRLRPLAQFWSHQVLKNDALRAHVDGSHSLAYASLAIRLDNALFGIAAKQDNWRVMHSLVKDKLPRDRWTPYMCLALLRAKSTVALAQVPRISSSVSYDPVAGHQKDEQVKLELWNMFLSEFGHYLRAAQVSETDPNQKTVLLSPWIIAALMELYSRSGKPEQTWNLLHMYTTMLFRDTLPNQYRKSSRPFVLRNSASRLLSHRHIYIPGPKLLNAILRAYLGCQKPAMALEAFSELSSTPLPAALAIPGAASPIDTRLVLEPNNQSILLVMDAIRYQKTLNHEAICLMLSFLKQIDRTWGTWRARDEPLYHPMFLSLRPMQRLLDWCLQVEAYKLVRPILRFQQGLFRRELRWNISGNRSHLWLQVSNEFSLLQQWKATLDKLCSRRWVKHDQVDALYAMALRVAQYREEARGTKAIRILPRRRIIPKNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3L8</accession>
    <name>A8Q3L8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730647.1">
        <property type="nucleotide sequence ID" value="XM_001730595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3L8"/>
    <dbReference type="FunCoup" id="A8Q3L8">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3L8"/>
    <dbReference type="GeneID" id="5854954"/>
    <dbReference type="KEGG" id="mgl:MGL_2443"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2443"/>
    <dbReference type="InParanoid" id="A8Q3L8"/>
    <dbReference type="OMA" id="IMHQSEY"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="139" mass="15188" checksum="F30B4A2BE064DD4D" modified="2008-01-15" version="1">MGVGVIFADKAGIKFDQMNYTDQSAAIGRRAMSEADKAWESLSTADKALTWTKDHKFSVVIGSWLASMGGSWLYIQSQPLTFAQKLVQARVWAQGLTVASLIGMAALVQIPSAGDKLISGKGTDDHSWEKRLQEAQQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3M5</accession>
    <name>A8Q3M5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730653.1">
        <property type="nucleotide sequence ID" value="XM_001730601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3M5"/>
    <dbReference type="FunCoup" id="A8Q3M5">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3M5"/>
    <dbReference type="GeneID" id="5854960"/>
    <dbReference type="KEGG" id="mgl:MGL_2449"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2449"/>
    <dbReference type="InParanoid" id="A8Q3M5"/>
    <dbReference type="OMA" id="YRVVMNC"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="8"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="138" mass="15474" checksum="FF0F306CAA015515" modified="2008-01-15" version="1">MSHDANCIFCKIIDGKIPSMKLFETDKSYAFLDIGPCSQGHSLVIPKYHAAKMHELPDDYLQDILPIAKKLAIATGAAEYNILQNNGRMAHQVVDHVHFHVIPKPSTEKGLVVGWPSTQPPKEELQAIYEKLQQNMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q455</accession>
    <name>A8Q455_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730118.1">
        <property type="nucleotide sequence ID" value="XM_001730066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q455"/>
    <dbReference type="FunCoup" id="A8Q455">
        <property type="interactions" value="438"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q455"/>
    <dbReference type="GeneID" id="5854425"/>
    <dbReference type="KEGG" id="mgl:MGL_2500"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2500"/>
    <dbReference type="InParanoid" id="A8Q455"/>
    <dbReference type="OMA" id="FGNMANF"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="7">
        <location>
            <begin position="272"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="6">
        <location>
            <begin position="631"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="92593" checksum="5A8BA9038AAD3367" modified="2008-01-15" version="1">MAHGGVRLKKRERPMPKQNARTPNQEKKQLKKHSHKRARVDGNGEDVDDSWVQDAQDMAVDAEPGQLHFLSEARLPDVTSSGAQGRAKERVRDEKRRQREILDAQRTDAKDESDESTDMEGASESDEDEMDWDKDISEDDLEESDLDEDADEHDPLEDAYLLKAEQREKRARAERHALAQLPLPVRTSEGIIEQPNSKESRNSRAIYEPHVMEDSDDDDDDNDNGDVSKTSPGVTSSSSADAQYLGYQTPYDIAEWALASNRTTSTQAILAAREQIARLSSSIMADPEQGQASLRRLLVFAQRNVHVPPEDPRPRTKRLPMHPYIRQLAMLSLLAVFVDILPGYRIRALSETEQKDRVSQDVARRRDWEQGLVRLYRDYLECCEGDVRDASSPLAPVARKCFCTLLVRAPHFNYRKNLLASVISLLSRKAWTPASEQCFEALAQLLRQDADGELGLELVMLLYRMIRERKLAVHANVLEILVHLRLRDELSRRVRRGPMGSANASNSMPTASEVRHADPRQVRKGLAVHRSKKQVKRDRELRQIEHEMREADATLDLEERERRQSETLKLMFALFFRILKTDDVPLPLLASALEGLVHFAHHVSADFFRDVVGVLRTHVTKAIDAHEPRHALLCIVAALELQAGQGGALELDLGAFYVALYQVMWPLAMSTQIEEGAPRQGSSVRGLRSWSMASMLFHALELALVKSSRSTLHVSLDRTAAMLRRLLMSALHWPTTTTLHALQIAHAILARAASVDTRFEALVDNRDAIHDGTFDPYSEQPESARVLASGQPCWELIMLSRTHANAQVRETASALLEWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q461</accession>
    <name>A8Q461_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730120.1">
        <property type="nucleotide sequence ID" value="XM_001730068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q461"/>
    <dbReference type="FunCoup" id="A8Q461">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q461"/>
    <dbReference type="GeneID" id="5854427"/>
    <dbReference type="KEGG" id="mgl:MGL_2502"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2502"/>
    <dbReference type="InParanoid" id="A8Q461"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="230" mass="25654" checksum="89F9000282FB749B" modified="2008-01-15" version="1">MLPAASRNAVFGVFTRPMLSAMRMQTSLPQRFYSDKAEEQKKTDNDNGAVPEKESAQSETAPEEDATTKQLKEKDARIKDLADDLLYCKAELQNFQRRTAEEKKTMGDHAISRLAKDLTESIDVLDLALRSVPESLRKSSQTDEPSRALAELYDGVSLTRKSILDMLRTHGIEAFNPIGEKFDPLLHEALYQAPVPSKQPGSVLDCNKIGYMIKGRLLRAAQVGVVQETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q473</accession>
    <name>A8Q473_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730124.1">
        <property type="nucleotide sequence ID" value="XM_001730072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q473"/>
    <dbReference type="FunCoup" id="A8Q473">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q473"/>
    <dbReference type="MEROPS" id="M67.973"/>
    <dbReference type="GeneID" id="5854701"/>
    <dbReference type="KEGG" id="mgl:MGL_2506"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2506"/>
    <dbReference type="InParanoid" id="A8Q473"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="10"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="325" mass="36676" checksum="159555A3D84BA81C" modified="2008-01-15" version="1">MSMISAATTVVVHPLVLLSVTDHASRVSISSRKRVVGVLLGQDNGKSVNVANSFAVPFEEDEHDPKTLFLDHDYIDGMLEMFKKVNAREKMIGWYHTGPKLRSSDLEINELIKRFTPRPVMVIIDPQRDDVGIPTDAYVAVEEIKDDGTATQKTFMHVPSTIEAEESEEVGVEHLLRDIRDTTTMGSLSDRVSQQLASLHGLHRRLMDIRDYLQAVLRGELPVNHEIVYELQNVFNYLPDLEKPETVRSFRVANNDRLLIVYLSSLIRSVIALHALVNNRLEMARGEHNTDEKNGTDENKDKKLDDQGGSVPKESPQTKDSLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4A0</accession>
    <name>A8Q4A0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730133.1">
        <property type="nucleotide sequence ID" value="XM_001730081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4A0"/>
    <dbReference type="STRING" id="425265.A8Q4A0"/>
    <dbReference type="GeneID" id="5854440"/>
    <dbReference type="KEGG" id="mgl:MGL_2515"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2515"/>
    <dbReference type="InParanoid" id="A8Q4A0"/>
    <dbReference type="OMA" id="IKNHYKV"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="202" mass="21316" checksum="4B03EA763CF9290A" modified="2008-01-15" version="1">MTYEEMIIEAIMAHGDDARSGLGRPTLKKYILMKHPDTSKLPLASFNSHLNQAIVRGKDKGVFLLPKGVSGKIKLAAKAKHAADKSNAKTSVTKKAAPKKKTSKPDTALQGSQKKTKSSTTKRVTAKKPSTSQGKNTSARSTKARSTTKKGTTSSSSRKAAATTKATADRKGTAKTNSSASSSKKAAPAKKATAKVRIVQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4G7</accession>
    <name>A8Q4G7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2539</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730157.1">
        <property type="nucleotide sequence ID" value="XM_001730105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4G7"/>
    <dbReference type="STRING" id="425265.A8Q4G7"/>
    <dbReference type="GeneID" id="5854464"/>
    <dbReference type="KEGG" id="mgl:MGL_2539"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2539"/>
    <dbReference type="InParanoid" id="A8Q4G7"/>
    <dbReference type="OMA" id="LEIVQCR"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000236">
        <property type="entry name" value="Vacuolar protein 8, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000128">
        <property type="entry name" value="Vacuolar protein-like protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="199"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="435" mass="47321" checksum="C6DB7BFB1A273283" modified="2008-01-15" version="1">MLSPNVEVQCNAVGCITNLATHDENKSKIAKSGALVPLTRLARSKDIRVQRNAAGALLNMTHSDENRQQLVNAGAISVLVSLLSSADTDVQYYCTTALSNIAVDSVNRKKLAQSEPRLVQNLIGLMESGSLKVQCQSALALRNLASDEKYQIEIVRSNGLPPLLRLLRSSFLPLILSAAACVRNVSIHPMNESPIIDAGFLHPLIELLSHEENEELQCHAISTLRNLAASSERNKAAIIDAGAVERIKDLVLHVPLSVQSEMTACTAVLALSEDLKPQLLDMGICEVLLPLTDSPSIEVQGNSAAALGNLSSKADDYSPFNAVWEKPAGGLHGYLVRFLESDDTTFQHIAVWTLIQLLESGNRDLEQHIRESPHLLQLVRQLQSREDGSHTAEEDVDGTNQDLSPEREIAALSRRIEEILFDDSDGDDEGAGNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Q3</accession>
    <name>A8Q4Q3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730222.1">
        <property type="nucleotide sequence ID" value="XM_001730170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Q3"/>
    <dbReference type="FunCoup" id="A8Q4Q3">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4Q3"/>
    <dbReference type="GeneID" id="5854527"/>
    <dbReference type="KEGG" id="mgl:MGL_2604"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2604"/>
    <dbReference type="InParanoid" id="A8Q4Q3"/>
    <dbReference type="OMA" id="PNIKPFC"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="315" mass="34591" checksum="D0BD0E6E2125FED0" modified="2008-01-15" version="1">MTSTVPLIIEYALASPEVTLEAITLTFGNTTLDYAHSNILRLAHALEVANKDGAIKNATLRERIEHGFNGKPVPIALGAEKPLGGRLFTASYFHGRDGMSGVSFIEGNPYPATKSSVLFGSRPANLPADECILDILRRHPPHTVRIAAVAPLSNLASAYLKDPETFCRVGSISVMGGALDVPGNTSPTAEFNFFADPWAAKVLLEDAVHDGRPLPIQLLPLDTTSRHTVPYELLVLDESSELYKTNYLFRLISLFLRKPRAVTNSFALKVFRSMRRNTTCLRHTILWPSRMRSFVQTPSSGLAQVDHSSLRQKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4X7</accession>
    <name>A8Q4X7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">MGL_2667</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730285.1">
        <property type="nucleotide sequence ID" value="XM_001730233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4X7"/>
    <dbReference type="STRING" id="425265.A8Q4X7"/>
    <dbReference type="GeneID" id="5854590"/>
    <dbReference type="KEGG" id="mgl:MGL_2667"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2667"/>
    <dbReference type="InParanoid" id="A8Q4X7"/>
    <dbReference type="OMA" id="YCDVVQL"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="372"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP43071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="428" mass="48787" checksum="1EEFECABF525A607" modified="2008-01-15" version="1">MREEKVTSLSTPARYRYPRSAQAEIVRLHQKDTYYRDAFHEQLKEFAINVFGSRATHKYENLLILGSSLVYFGLCTLNGAQSLGEEYVNAMMRHRKTGHIVSAKRRAAFLLLYVVAPYIVARSYSAVRAWVVRVGALNDEKREEEKQLESMGIVGMENPTLCSRIWSRWKVDELIHWLSRHLPGAHELAGSHGFFAYVSAAQLAMFYLWGRYYTLAHRFVGADYMYASARRPGSPPMSYEVLGVLLTIQFLVKLGLMWRNRLLRANGGVAVRDVIFASRSRNPNQKPHLKLDDKEVFPHDGTVVTREPGMFMPQPYTFPLIYPCADGEVKPADLGMEQVSTEEESRDFDAAQAAIRTRTAQLEAISSQILRCTLCMDRREPQKGDSAVTECGHVFCWACIEEWLSEKPECPLCRQGVSITQLMPIYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5A9</accession>
    <name>A8Q5A9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Yos1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730385.1">
        <property type="nucleotide sequence ID" value="XM_001730333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5A9"/>
    <dbReference type="FunCoup" id="A8Q5A9">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5A9"/>
    <dbReference type="GeneID" id="5854690"/>
    <dbReference type="KEGG" id="mgl:MGL_2767"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2767"/>
    <dbReference type="InParanoid" id="A8Q5A9"/>
    <dbReference type="OMA" id="VNSACII"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728099" description="Yos1-like protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8386" checksum="2A32703360572CDD" modified="2008-01-15" version="1">MLGLGTVLYVALLLVNSIAILNEERFLSRIGWSTNPRSLHGLDGAASESSVKQRLIHLISAVRVLLRMIIYELILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5B7</accession>
    <name>A8Q5B7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730391.1">
        <property type="nucleotide sequence ID" value="XM_001730339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5B7"/>
    <dbReference type="GeneID" id="5854696"/>
    <dbReference type="KEGG" id="mgl:MGL_2773"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2773"/>
    <dbReference type="InParanoid" id="A8Q5B7"/>
    <dbReference type="OrthoDB" id="3360632at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF671">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_75, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="55622" checksum="5CC950497CBBF62C" modified="2008-01-15" version="1">MVTDPMAIDPSTSSAASRYDQVAEQDESPMEEVIHIHGTEENQHMQLVGNGSTSEEDDFDHGLVRVWDEDSDDDEHDASRSTNHSVIPSFHLGGRLHSSHRPEFPSIQNWWRTLLIGSAAPGTLSTGHVAINLFSSGLHPGVLLAMPVYFCKSEVVPGMIVLTLVALLGIFGGGLWVALGRYVGGHTIESITSKAFGMNTRWKRNIGHGISSVALVMYCTGAAVIAYHAMTDLLLQVFFHYTAKGQLLHDRAFVTLAIGGALTLPLLLSSTPKRNMFQIQSWAVLLSYPAIIGILLARINDWNLPGLQKTSLSDRFSGDPTLLVPQPHLSDYSWPWASTAMLPLLTLSASPAQILAHNRSLKRKNAYESNVLSFLFAQFIQIALIIGTTYVVGVEIGTLGSSKFLGGLHANFFNALPLDDDYVNTARVLFAILLAAHLTVCLASARSCWSRLLNLLNLNPLGAMTPPTPQIVSRRMPQRHRSSSLFFSPAWLPSNWYSPSVPSSEATYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5R2</accession>
    <name>A8Q5R2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729821.1">
        <property type="nucleotide sequence ID" value="XM_001729769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5R2"/>
    <dbReference type="FunCoup" id="A8Q5R2">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5R2"/>
    <dbReference type="GeneID" id="5854128"/>
    <dbReference type="KEGG" id="mgl:MGL_2807"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2807"/>
    <dbReference type="InParanoid" id="A8Q5R2"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="9">
        <location>
            <begin position="592"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="783" mass="87413" checksum="11952E2EB5182C29" modified="2008-01-15" version="1">MNEDSDTSAISERTIGRQINSSAFRWNDPHTLVSEMEDTANEHTPLWPDRTHSYDTITEPRKEVSTGQEAIEAVNHRWIALRSRMNVLKDKTVSAWDRPWKWLQTLGSMTPKDWEKALTEPVRLIPAVILGLFLNILDGVSYGMITFPTTMPIFANFGGDGVSMFFVTCIISQLIYTLGGSIFKGGNGSMMIEVVPFYHILVKDIVRVVGEDNGAAIVPTTMVAFALSSILTGLLFLLLGVFRLGVLISYFPRHILVGCIGGVGVFLMETGFSVSARIESEGGFKYNWDTIRQLTVNIETILQWLFPLGQAVLLNVIASRCKHPLLIPAYFLSVFVLFYFTTLVVLRMDMSDLWSRGWVFDIQEAAHAPFYRFYTYFDFGQTSWKAIWASMPTQMALVFFGILHVPLNVPALGVSVGEDNVDTDRELVAHGISNMTAGFLGTVPNYLCYVNSVLFYRVGGGSRLSGLMLAGATLVILLMGPSLIGYLPIMVVGALIFVLGLDLFREAVWDTWNRASRLEYLTILVIIVVMTLSDFVVGCLAGICLACVFFVMQTSRRNAVRTVFSGRAARSTVRRQLTQRRFLDDVSNQTQVLKLQGSLFFGTINSIETLVRKMLDLADWQHYPISFLIMDLGLVHSMDFSAVEAMTRIHRMLMMHGVHLVFCGLSLEGDVASALQSVDLWADEAKQVDVFASLNEALEWTENEYLRGLYSSNLTAATHLRQATMSGPSALRLPNVQRKPTIELDDTVQDSPRYQHLHEAAERVTQDIQAHIKTGSAHKVTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5U0</accession>
    <name>A8Q5U0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">prolyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2816</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729830.1">
        <property type="nucleotide sequence ID" value="XM_001729778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5U0"/>
    <dbReference type="STRING" id="425265.A8Q5U0"/>
    <dbReference type="GeneID" id="5854137"/>
    <dbReference type="KEGG" id="mgl:MGL_2816"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2816"/>
    <dbReference type="InParanoid" id="A8Q5U0"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722:SF1">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="45"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="133" mass="14818" checksum="E247402B5642726D" modified="2008-01-15" version="1">MYLSKATNEDWKYSQTDPYASGYLDVENGMHHVFWAEYGNPNGIPVMCIHGGPGGGSEAFVARFFHPEKYRVLMFDQRGCGKSTPSASTDNVTAALSNNTTAHLIDDINQLRKTRRIDTPMCLYAVPRGVEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q633</accession>
    <name>A8Q633_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729861.1">
        <property type="nucleotide sequence ID" value="XM_001729809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q633"/>
    <dbReference type="SMR" id="A8Q633"/>
    <dbReference type="STRING" id="425265.A8Q633"/>
    <dbReference type="GeneID" id="5854168"/>
    <dbReference type="KEGG" id="mgl:MGL_2847"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2847"/>
    <dbReference type="InParanoid" id="A8Q633"/>
    <dbReference type="OMA" id="QEEWHCK"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="234" mass="26483" checksum="3F7D1F23ABAFB1F0" modified="2008-01-15" version="1">MLEAVQFIHEKGNLVHTDLKPANFLLAKGRLKLIDFGIAQKIPIGTIHISRDAIVGTPNYMAPEAIKIAKAHGRRVYKAGKASDVWSLGCILYQMVYGRPPFDRFMGEKKLETIMDPQHHIPFPPHRVLDDPSSERVDPPMLEALTSTLHYDAQQRARIPALLESELLNDHLHETVTLTRKTLRALVARLRLHSVQGELNEDNVIQCTDVRMREPCTLCFSESLSYFTNMLGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q675</accession>
    <name>A8Q675_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729885.1">
        <property type="nucleotide sequence ID" value="XM_001729833.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q675"/>
    <dbReference type="GeneID" id="5854192"/>
    <dbReference type="KEGG" id="mgl:MGL_2871"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2871"/>
    <dbReference type="InParanoid" id="A8Q675"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="562"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="997"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="733"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="836"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="866"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1354" mass="150258" checksum="7242A04AD04284F9" modified="2008-01-15" version="1">MSTSDMFSTSRPPGMGMRLPPSRIESGRSAPDFEHMRTADTLSTPHEPMHNQTTTYPAFVKVDALPPSTPAPASEPLPSIPAFPPTEVPLPPPKPSDVYPPQVVHVGPPFVQPSESGTHMATEHQAPDNALASKIRDHPAAQRSWPEYQPEVNYHHNFDTSTSTLDQSVGNISLPVGIAAGGSHLPWTSHNEPIDAPPSSELATAVISPPPQNQELYPDNTRAGTEPNVSSVSETVDAPYSGVGDALVRPYHVSADGSSYRLSTWTMPEQEDSVLSDKPMSGDMKDTLALESASSPNRAKNQQTRTSVKLDNNTIVTAEPSLFDSTSSSQTVPPLDVTKMVSRDSGSFLSQDDVASGASPVKTAPRASQPPGLLPRVAELQEDQRSLVSPQPVVEPKPEHTIRSTNAQKQFAQHGAPAPLSESVQTSTPVTSQPQLYRVECMLGSHTLVYNDPVLQGMPPKPVAYTYDNWYLEPVPPPTSVQRGPSISAIVAKSPPAQQAYAVPLCLGVFTSHLERMEEGGYVLDVAVPMELEGPPHVAPSQEPRPVSLSLCLRNAALFSMSSHLVIAATPHRLVAEMTSGSSPGLMQDILLGYRQCFNARRLLDLLLLRMEWAIQKLDDPHIVSTALRVLTYSQSALWHWLRHYYQDDFQNDEALTRRLVQWTADQDARCQFWQVAKAVDAPEKPLVAPHLPVPPITTRHAHNEELPATEPQERMQVIYSLVQALVPASLLPPREEKGDEKKESFFLRKSRSLSRMLSNTQSSPRSRRGHSRKSSGMSGTSAGGAGQTPSMRTGSGAWPVPTTSATAVPPPTPPRRVSDEANSSGIGANADVGISTDTSTDMPETKSQIGRSRSMRSLRRMLQRNGASGVSGSDTCNINSFESTPDEDSRGSVRKYEKLVPDEDGDVDMDGDEHDTALQQLEQALSDTPRAEDLHSARVREGPFQWIPRHNTSTWKEAQRMSMMTAKEIQPHVPQQARGSVEPAVAPRDSFLLCQRSSTIARQLSGVEREIMSNVKWTELSEAFWDQHTVRQEQWQLEYQEFVALRVREAMGEKEESSRRKCFDGKGIHMLIARFNRTCAWVASHIVKATNLSERVAIVNKFIRIAWHCYRQGNMESLCQIMFGLQSPWVARLQQTWDRVAMWELRAFEALRRFTSPRDQFAFLRYSMREAVESNVPMRRFSKISTPSKPYIPFFGLFVSDLSTIDSLASFVDAAGMPNMMPLYDDQELSQSWDALVNVYRMRMKACIVREFITLQQYQRHATSYPVELPILVEMLQLDTLSAMAIQRYALHESLCYTANHLAARHSHWSPECIPSCMQLHAISLLCAHVVLEWHIEMEGSALSVPVERRAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6D6</accession>
    <name>A8Q6D6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729946.1">
        <property type="nucleotide sequence ID" value="XM_001729894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6D6"/>
    <dbReference type="STRING" id="425265.A8Q6D6"/>
    <dbReference type="GeneID" id="5854253"/>
    <dbReference type="KEGG" id="mgl:MGL_2932"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2932"/>
    <dbReference type="InParanoid" id="A8Q6D6"/>
    <dbReference type="OMA" id="PHANEMP"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="544"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="806" mass="88219" checksum="0EE591488410B545" modified="2008-01-15" version="1">MRTRLTRQPYHLPFPSKKKSGDEASPTPPTASGESSSVSVHPPHQHQANGDDTKNLVRCTTSHLPRDSNSTAHAAPAHRAAEPTSPASTVSPTQQQCSQGPSATHCSRPIAQSYGSNISSDMASLRSSPTGHSHTSVEECTDTSETESVTSAFSAEPSETPGSLPPPFLYPVPQDAIPHVTNPASGYATPLVQTSPAPHISSTSFISTPHLLRSPGPPLSVSTAGLRVSPHAMGMQPSVSPAHAGHVRPNSHETTAQSQLAPHATPQETFVSPYLSPMHQQKLEEYHQTSMPSPLTLHSPLEQQQQSSSSASLLLPPSSTRAQPANQDHDEIPPTPTEIMTRRSSKMGAPALWMTSQAPTPSGSATPTVVRSQLGTPGFTPSPSSCWNALGIGRGRLGTSAMTPIEAPASNDVPVCSEPLEHQTRKGLASEPEMTDESQVSQPLWQRRLQRNEKPFINLAPVTTVSNKAKETEGDSRELDDTNIMLAHATQALNCLVLEQERALVAEEGRRNMSLLDGNRHSLALMGSEPPKDGEEELPPYECTVHIEGYLPCKMEVHGSGDPSKMHDWKSLYFVLHGTALHLYKKDISLLYSKRVNLINVWHVQDGALVHTVPMNEEPHANEMPSGRNLKHDEKAHTNPLPLEDLVLRGIELGRSLAHTTSDTTQTRTENVEKELDDVQRALKNHHAHTYSMEGAQCGFAADYTKRPHVIRVKVASDQFLIQTRNNYHLVDWIEAIQGSINVSTDLDRRTMPKFVTLPRRRRRRRDMEAMVIRDQNAEQHRRPSIQSPTSISDSHLNSYAQNLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6P9</accession>
    <name>A8Q6P9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730042.1">
        <property type="nucleotide sequence ID" value="XM_001729990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6P9"/>
    <dbReference type="STRING" id="425265.A8Q6P9"/>
    <dbReference type="GeneID" id="5854349"/>
    <dbReference type="KEGG" id="mgl:MGL_3028"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3028"/>
    <dbReference type="InParanoid" id="A8Q6P9"/>
    <dbReference type="OrthoDB" id="3269056at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="302" mass="33903" checksum="764CA3B343F16291" modified="2008-01-15" version="1">MGRRRADRRRQERIMPRDISSSDEEGDSRLRGPRVFDHSDDEPEGIVGEDEDIDSDEAFGEDDEYEMGQMSGRYTSRKPEKYNDNNEGDEEDDMNEEDEDEDEEDGEDMVALSNLLDEAPEDDEPGSGSEEEDDGQNGKYHEDDLDDTDWGAIWTKKRAHHDDELVPQKRRPARTERTEAVHESTDAAGGGAKLRLEDLMAHGSGASLQNVQALTEKRNAIGQQPVASKRGGGVLHAPLPGIVQDRLDRVEAYKLSKEEVEGWAPTIKRIREAEHLSFPLQPPAQPPAAVKCRTHCILYAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q798</accession>
    <name>A8Q798_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3316</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729772.1">
        <property type="nucleotide sequence ID" value="XM_001729720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q798"/>
    <dbReference type="STRING" id="425265.A8Q798"/>
    <dbReference type="GeneID" id="5854078"/>
    <dbReference type="KEGG" id="mgl:MGL_3316"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3316"/>
    <dbReference type="InParanoid" id="A8Q798"/>
    <dbReference type="OMA" id="GKTRWQR"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000410">
        <property type="entry name" value="Peroxisomal multifunctional beta-oxidation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="584"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="770"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="881" mass="94662" checksum="91683B76144C673C" modified="2008-01-15" version="1">MADFPATENGKISFKNRVVVVTGAGGGLGKTYALFFASRGAKVLVNDLGSTPDGKKAADLVVEEIQKAGGEAMANYDSNGEGAKIIQQVIDKWGRVDILINNAGILRDRSFKSMSDKEWDQVMAVHVHGSFACAHAAWPHMRKQKFGRIINTSSAAGLYGNFGQANYSAAKLSLVAFSKTLGIEGQKYNILANSIAPVAASKMTETVMPPEMLENLKPDFVVPIVAYLTSAENKDVNGEVFEMGAGFYAMLRRERSHGHVFRTDASFTPEAVREQLNTILDFDERPEYPQRITDANYLELLERAKEAPENPQGDHKINYKDQTVLITGAGAGLGRAYALLFGKLGANVVVNDMSDKAAIAVVDEIKKAGGKAAPSIGSVEDGEQRVKDAVDAFGSLHVVVNNAGILRDKSFAGASEKDWHLVMNVHLRGTYKVCKAAWPIFSQQKYGRIINTTSAVGIYGNFGQANYSTAKSGILGLTQTLAVEGERNNILCNTIAPNAGTSMTATIWPQEMVDAFKPDFVAPLVAYLGSNECETTKSLFEVSGGWIAAVRWERAGGCSFSTAKPVTPEMIQKKWAKITDFDPERASWPTAPSESLGDMVANFGNEEPEDDDGADAAAGGDYVDPEDTPEIKQAKQTEFESTDFAYEDRDVILYNLGVGATEKDLDLVYEQADEFKALPTFGVIPPFSAGGSIPFDSFLPNFSPMMLLHGEQYLAIKGPIPTSAVLVNKPRVIEVLDKGKAAAVTTLTTTVNKNTGEPVFENQMTTFIRGSGGFGGKKTGRDRGNASAANKPPSRPADKVVSEKTTESQAALYRLSGDLNPLHIDPSFAAVGGFDKPILHGLCSFGIAGKQVYRAFGPYSDIKVVERGTQALGAAAVTLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7J3</accession>
    <name>A8Q7J3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical phospholipase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729533.1">
        <property type="nucleotide sequence ID" value="XM_001729481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7J3"/>
    <dbReference type="STRING" id="425265.A8Q7J3"/>
    <dbReference type="GeneID" id="5853839"/>
    <dbReference type="KEGG" id="mgl:MGL_3077"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3077"/>
    <dbReference type="InParanoid" id="A8Q7J3"/>
    <dbReference type="OMA" id="PGEWIED"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16014">
        <property type="entry name" value="PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728004" evidence="2">
        <location>
            <begin position="28"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="654" mass="72827" checksum="36798479A7D4A83D" modified="2008-01-15" version="1">MFFNQAWASALAVAFAVALGSAGSAHASESGEQKWSNPGKDLKKIKHIVLFMQENRAFDHYFGTMHGVRGFQDPNVMVSNNTGQSVFHQPVDKTILSPAPPKDVHELQPFYLNWKGGDWNEKTQCMLAGVNDWVFNHAAWNNGENDHWALRNSVYSLGYFKEDEIPVQWNLADSFTVGDMYYESIIASTDPNRVAFFASTINPQHGSTVEGSNKHMGGPVLNNHASDGCQIAANGGPLSCMPLRWKTVPEYLQDAGISWQVYQDEDNFGDDPLAFFSQYEESSKHKGELAKRGTSYVGLKKFYEDARDGNLPEVSYIVAPENLSEHPPFMPKDGAWIQRKVAEAVMNGKDWDSTALIYSYDETGGWADHVMSPHPPRSEKGEWMVDPFLNFKGIQPIGPGYRLPFYIVSPWTRGGHVFTEHAAHESQTMFLEKWAEAHGKGFQSKEIPTWRRQQLSDLVNAFDFSKEDTSVPYIPRVRKPSQDHLTHRFNGGIKCLISHAGLVFPPVPYGKQDSSNSMQVNKGYKSVRGDLTEGRKLAFEANGRALSHANGKLGTSATKKNHDGGDQLFILHWLGSAPKDNRFHIATEKGDYITKKLSLSDNKNDAGVFSIRDVGNGAGYNVTELNAGKQVTISKDGSPEFGDSSFLKIYSVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7Y2</accession>
    <name>A8Q7Y2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729612.1">
        <property type="nucleotide sequence ID" value="XM_001729560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7Y2"/>
    <dbReference type="FunCoup" id="A8Q7Y2">
        <property type="interactions" value="820"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7Y2"/>
    <dbReference type="GeneID" id="5853918"/>
    <dbReference type="KEGG" id="mgl:MGL_3156"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3156"/>
    <dbReference type="InParanoid" id="A8Q7Y2"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="290"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40882" checksum="EAA07BA6C6B66AA3" modified="2008-01-15" version="1">MGVAEKIKEVEAEMARTQKNKATEYHIGLLRAKLAKLRMQLLEPDKKGGKSGEGFDVMKSGNARVVLIGFPSVGKSTLLSSITETESETAAYEYTTLTAIPGVLEYEGARIQLLDLPGIIEGAAQGRGRGRQVVSVAKTADLVMMMLDATKSAQQRPLLEKELEDVGIRLNQNKPDVVLKKKSGGGIVVTKAMGLTLTKIDEKMIRSILQGYKIHNCDVMIREDITVDQFIDVLLGNRKYVPCLYVYNKIDGISMEEMDRLANEPRSVVISCNLNLNLDYLIERLWEELNLNRIYTKKRGQHPDLKDPIVVRRGATIEHVCHGVHRALVDKFAYAMVYGKSSKFPLAQKVGLNHLVANDDVVTIFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q841</accession>
    <name>A8Q841_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729653.1">
        <property type="nucleotide sequence ID" value="XM_001729601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q841"/>
    <dbReference type="STRING" id="425265.A8Q841"/>
    <dbReference type="GeneID" id="5853959"/>
    <dbReference type="KEGG" id="mgl:MGL_3197"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3197"/>
    <dbReference type="InParanoid" id="A8Q841"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12276" checksum="691BA09F3BC17AE9" modified="2008-01-15" version="1">MTTTPSLLTAEEVAAPAASGVPEEAARVLAQLARHQHVRGCIALTASDLRVIWSGGVVFASKEKLAQIVHFVRDTLNVTRRHYVYIQVHHEELCSQSGETYVLVVLQDPNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q855</accession>
    <name>A8Q855_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729662.1">
        <property type="nucleotide sequence ID" value="XM_001729610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q855"/>
    <dbReference type="FunCoup" id="A8Q855">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q855"/>
    <dbReference type="GeneID" id="5853968"/>
    <dbReference type="KEGG" id="mgl:MGL_3206"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3206"/>
    <dbReference type="InParanoid" id="A8Q855"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="270" mass="29434" checksum="1FC9DF86063ACDF1" modified="2008-01-15" version="1">MTAAKALATVHGKPLVYVHHMRAHALTPLLTEPEPPSFPFLTLLVSGGHTMLVLVHGLDAFQILANTLDDSVGNAFDKFARELELGWQSASGALVEALAAQHDPLQAVDKPYLPRILLGTPTFSYSGLRSAAMRQISIAGGARTMSSKEKAALAYDFQLAAFAPLEDKIVRALVPQRGRGWQLANSCASIHPHEIRSVVCSGGVASNAFLRRRLRDALDSHGRHDVTLHFPPVSLCMDNAAMIAWAAHLYWHERTHDLSPHVVAKWPLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q871</accession>
    <name>A8Q871_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729672.1">
        <property type="nucleotide sequence ID" value="XM_001729620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q871"/>
    <dbReference type="FunCoup" id="A8Q871">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q871"/>
    <dbReference type="GeneID" id="5853978"/>
    <dbReference type="KEGG" id="mgl:MGL_3216"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3216"/>
    <dbReference type="InParanoid" id="A8Q871"/>
    <dbReference type="OMA" id="CMRQSRQ"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000050">
        <property type="entry name" value="Related to MRP4-mitochondrial ribosomal protein, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41841" checksum="5156090773D99803" modified="2008-01-15" version="1">MVWPLRLARSCVRITKPRVFVSRRLSSSIPTSSSAAATFSIPEQPIDVPHADANAVQTSQQDVRAQLETEDPVGAQDALERQIRRMRRNMMLDMSGMASTQTRDTSFRPFKMRTQPVEPHQLTLSHLLAATAQMGHAKQHVTRSFEPYLYGYRHGMGVIDVERATLPALRRAIQVVRGITENDGIILIIGTRPNLRPAIRSAIERLGGNGFHVSMDRWLPGVLTNASKLLASATQYSVRSKHSDDDVEEVPNMTKLATQGYRPDLVIVLNPTENGHALREATQCHIPTMGIIDTNVDPRSVTYAIPANDDSPRVAELVIGLLSKAGEDGLRRRRAALEAWEKSQRHQKRKNTSSTSTSTSSSSPSSSSSRGRSSPRPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q907</accession>
    <name>A8Q907_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729349.1">
        <property type="nucleotide sequence ID" value="XM_001729297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q907"/>
    <dbReference type="GeneID" id="5853656"/>
    <dbReference type="KEGG" id="mgl:MGL_3384"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3384"/>
    <dbReference type="InParanoid" id="A8Q907"/>
    <dbReference type="OMA" id="QEHGQNA"/>
    <dbReference type="OrthoDB" id="3355916at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="90" mass="9292" checksum="DFCFF47AB8F2D324" modified="2008-01-15" version="1">MSNFMNQAQDAVSQAGSKAQELAGQAKDQISNFGQGGQGGQSISQQAGEYAGQAKEQAGNFGKQAQEQAGNLGKQAQDQVNNLSNQFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q910</accession>
    <name>A8Q910_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729351.1">
        <property type="nucleotide sequence ID" value="XM_001729299.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q910"/>
    <dbReference type="GeneID" id="5853658"/>
    <dbReference type="KEGG" id="mgl:MGL_3386"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3386"/>
    <dbReference type="InParanoid" id="A8Q910"/>
    <dbReference type="OMA" id="GTHIVHP"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1441" mass="160111" checksum="4ABEE5AF7679D424" modified="2008-01-15" version="1">MVQDTSRRRLDAVTRHFHASLQYPAKSLSAANELGTFRLGPHVAIPVHAADAPERIPPERLLLDLEDPIVLEHLEFLGKKWQLRQDVFLSSPPGPYTRRLCQTFAALIQVPVEYVSLHRDIGEAELLQQRSLEAGGNLRYDDGPVVRAMKHGRILILDGIERAERGVMPILNNILENREQNLADGTQLVPAERLTAANHQLQQDSGNAHARFIPVHPDFRVFCLGLPVPPYRGHPLDPPFRSRFQARWVEGAVFAPPPISDSTKQGSSLLERWNEWLTLLHMNAEASLQEGILPSTELLPHVPTTAMPLLRDMACLYPPSKNMPKPAGPADADTPVAESTLALLSTAYPALLSFDKKKRSSLHEMLTRVALHKGVGTSHMFSSGLGLSGYTIHHNERTSPSTARLTFRHESAASVTTEVPCGPLPLVPLTALEEMHVSLTPRVRSLLSAMLQLHSIGRDIALVPSSLDNELHTQASSSKSTCIHLFGALLGYPVETIWLWKDISGTELLMRRATTPDGATVWHPAPLTSAALRGSLVHLAGADVLGSTLESLSRLTQDREMELWEGTRLTTEADVPVSSQLVSGQVCHMSPSLRIIATAPKVGNWLTESAATMFATLAAPPMSDAEERAVVMKQAGAAPSASLDALFAFVHEYRAQATDTNVGLHKARRFGTRQLIRIARRLSKWPDEDLYNLIFRNQLCDFLPRTVRDVVHQTLLQAKIVPHGFEGAFQYKPPLRLMPPIVDGDMLRFVDENGTEQLALRRFHWREHDPEGASLIPNAHGSFFHNTQQTGLMYSFAQDLEILGEHLLLMGAQGTGKNKTIDQVLELLDRPREYIQMNRDSTVGELLQRAYLEDGQLKYSDSPLVRAIKLGRVIVVDEVDKCSASVSAVFKSLAERGELTLPDGRRVVPQGTVADADAITVHPDFRLVLLANRPGWPFLGNTFTDVVGEGFSSYAVSNPDVESEVQLLGRMAPNVDKELIRSLVLSFHDLREAFDQDQISHPYSLRELIHIVRHLSRYDDETLGDVMLNALAFDLHKPESLKIIARVFANHGLKLGGITLEQVQRKLEVQAKKKQLRVEYRPKGDTSLDKPKKGKDDPNNDPHVGGNTWRGGTGGRDTAGLGGRGGFERLYKGHKIHQIPKELKEDVPEHIQAEAREMAKKALAEKLAEDRLDRDEARFMQSVKANVEGQVLHLANVLNGLTANEHERRWLVRQQEGQLDERRLGEGLVGERAIFKRRSEAPPEIGAPQMKPKRIRIILDASASMYHMQFDGRLTRELETCLMVMEAMQRVDPTRFEFDIVAHSGDQVVIPLVKLGSMPKTDGDRFRILRDIVAYTQYCMTGDNTVECITQSIKDVRSQDADDYFVIALSDANLGRYAITPQVLGSALKRDEKVKAAVIFIDKGGAEAGHIAKALPGRAFVAEDTKDIPRVLSDILTSLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q924</accession>
    <name>A8Q924_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor spt8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729360.1">
        <property type="nucleotide sequence ID" value="XM_001729308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q924"/>
    <dbReference type="STRING" id="425265.A8Q924"/>
    <dbReference type="GeneID" id="5853667"/>
    <dbReference type="KEGG" id="mgl:MGL_3395"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3395"/>
    <dbReference type="InParanoid" id="A8Q924"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="2">
        <location>
            <begin position="246"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="378" mass="41090" checksum="1B75086651101331" modified="2008-01-15" version="1">MPDVMVHASATEPMDMELAESSTKMELEPKVESSLLADDDLEMELNRTLNEQMSDDKPESSRMMDEPDAEGENEGDNDSLFGGENDDLGEQQDITADGDADGDMDADGEADIENVANAFGETDADADADTDSDGGVGTSNGYGRADPKTAQPQRSAEHDTPPVPSERSASPSKTAERPGGAISLPGRQVNKQDDKKTITPQIPKQATPEAPHPVHQNSGRKTLPKPMFGSMNMAWQYDADVSRFSHDIMLTSTLSGQVMIWDRRVDPKSSKHGVRALALPAGTPPWCTDACWNHTGDKIYVGRRNELVEEWDVRMLPDISTSASHQNRSQYGTVPSLARTLRMPRGSGPVSSVAVLPNNRHIVWCVCLPVCQVCILAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q944</accession>
    <name>A8Q944_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729373.1">
        <property type="nucleotide sequence ID" value="XM_001729321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q944"/>
    <dbReference type="STRING" id="425265.A8Q944"/>
    <dbReference type="GeneID" id="5853680"/>
    <dbReference type="KEGG" id="mgl:MGL_3408"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3408"/>
    <dbReference type="InParanoid" id="A8Q944"/>
    <dbReference type="OMA" id="AKNDHAR"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000218">
        <property type="entry name" value="WD40 repeat-containing protein HOS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="306"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="445"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="500"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="551"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="653" mass="70545" checksum="DD2743FF6836B420" modified="2008-01-15" version="1">MFICQKSGFAADRRRHTRLLTRRCLIATTTACLYLGVLLADTILIPIAACVLWRLAHTRPIVQPGQLLHFLHRGLLYTEAERHVQKLRSITEASPSGANDNPSPSASLPKPEALVAPTCLTPSIEVQPEKVEKYVNASSQTSALPCQPSAMSPPIEQPGSASTPSISVGSTSAKRRLDWDVRASDKRSRNEAVAMDVSPPSGELQSEGSARRSKSKAKNDHARRSSSNEQPLPTTSSSRSPKITPSQPASIDPDAIVLSGHTAEVFVSAWNPTVPDLLASGAGDGTVRIWDMASPHDPPVVCKHLPPTQAKNVSSVAWNPDGTLLASGSYDGILRLWTPQGDLHLVMSMHQGPIFSVRWNRKGNLLLTGSADGSAIVWDVSSGRTRQQFSLHADNVLDVQWLTGRTDEKVAHPNQALADSLFATCSADNTVHVCKLGEPKPIKTYSRHKDEVNAIRFDPSQTLLASASDDGSVHIWALCVSGLAMATSVVQNDADPLHVLRGHTQEVYALAWNSTGPGSSHVDQPRMLATASFDHTARIWHGDTGACLRIIDGHEMSVYAICFSPCARYLATGGIDHRVLITRILDAHSKYTYMGDGAVMDLSWNKQNCTAEKTEHGERSVSASSSTHATSLPRISVALTDKHLVILEPRGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q952</accession>
    <name>A8Q952_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3413</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729378.1">
        <property type="nucleotide sequence ID" value="XM_001729326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q952"/>
    <dbReference type="FunCoup" id="A8Q952">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q952"/>
    <dbReference type="GeneID" id="5853685"/>
    <dbReference type="KEGG" id="mgl:MGL_3413"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3413"/>
    <dbReference type="InParanoid" id="A8Q952"/>
    <dbReference type="OMA" id="QRKDKYY"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="243"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="681"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="508"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="644"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="846"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="810"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="655"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="902" mass="103379" checksum="495D31DD4B9D1E43" modified="2008-01-15" version="1">MGKHEKKAGKGRLDKFYWLAKEQGYRSRAAFKLVQLNKKYNFLENAHCCIDLCAAPGGWLQVASKHMPPNSLILGVDLVAIKPIPRCITFAEDINSYRCREQLQEHMKDWKADVVLHDGAPNVGTAWVQDAYAQNELTLQSLRLAVEFLVPGGTFVTKVFRSKDYNNLMWVFQQLFHHVEATKPPSSRNVSAEIFVVCQRFKNLSRIDPKFLDPRYVFKELDPSGKDLLGTSSQNLLENVLNPEKSRRKREGYEEGNYTLYKTIGADAYIRGADAVAMLGTYNRITFDTDVDKTYLQHPATNDDIKANCEDLKVLGRRDFSSLMKWRKAVRQSMNLDARPDKTESHNVTVEMEPLNEEDAMDEELARLNEEASRRARKERRRRNEARAKSLQKLQLNMTLPADAGEDWQDRALQGEDMFSLDSVNRRPALERGANSVDLLDADEAQSSDNNDDVHHEQGNEEDDDDDDDLDVDDDRERRIRELESGMDTLYEQYQQQLQRRDTKYLAKEARRKSGKYEEWDGISSKSDDGTDQGDSDEDGPKAMGYDAMNKRKFHEETYDSDDAEDDEDERDNSRELEVSSDRSQLRKPHAAAKSTPKLSQSGDISLRPLEPFKSVDQQQSAASALWFDNPVFQDMVPLEMLAPMSKKVSREPTPELEEEGEEEDEEENDSEELDDQHDMDEDDDTMELVPSNELDSIPDDDWNVDDEDQVARNQERIRKHGLQTAEAVSMAHALVNRQMTKTDLVNQGFNRHSFNDKSGLPEWFLEDENKHYKTNIPLSKEAVEALRARQRALDARPIKKVAEAKARKKHRAAMRLERAQKKAEAINENADLSEREKAENISKIIARSGQKTEKKAPQLVVARGPNRGIKGRPAGTKGRYRMVDRRMKKELRAQSKSKKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q972</accession>
    <name>A8Q972_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729390.1">
        <property type="nucleotide sequence ID" value="XM_001729338.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q972"/>
    <dbReference type="GeneID" id="5853697"/>
    <dbReference type="KEGG" id="mgl:MGL_3425"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3425"/>
    <dbReference type="InParanoid" id="A8Q972"/>
    <dbReference type="OMA" id="HTRWWLT"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF10">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="825"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1307"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1360"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="680"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1562" mass="172738" checksum="BE19FB87827C5816" modified="2008-01-15" version="1">MEHPLSFLLDLPGPPAGASLGEYMASQVTDNGRVKTLLDCLPSTNKRALISPDLSRPPLTHRMLKQFVASFTVPNSAHLKPLAENNRVMMALPTGPENALALLCIACYFNCAPVNASCTAEELRDDALRLGARAVISTADSIQRLELDRLYSQYGIEILLVEPRPSGPAGLFDISLMGDEQPGSRQRGPPKPNGLMNQALVLHTSGTSGKKKVVPYTLRHLIVGACCVIQSWNLHSKQVDMNMMPLFHVGGIVRNLWAPVLSGGSTILCAGFDPNAWWTLTMQLGATWYYAAPTMHHAILASKPADVDPSTQLQIGMICNAAGGLLPSLANELRATFNCAVLPSYGMTECMPIASPPVTYKLERPGCSGVACGPDLSIRDQLDINKELERGQTGAICVRGVPTFSGYEMENGELDTSVFSKDGWFDSGDCGHMDQDGYLYITGRSKEIINKGGEVVSPFEVEEAISQACKERVKQTLAFSVEHKVLQETIGVVIVPKPGQPRIGLVELQNLLRNYLHPSKWPFVIVYMDDLPKNQAGKPLRIKLGSRLGITGMSDDVPALDRHFESKAPSKETPLSRPIACSRVTVDSRAVQRACYRIPGVLDAAVAQQRDRSLMAYIQVSEDAEFDAADIDRALSQILHGYAVPNPLHVFRQPLIKTNGEYDFAAMESIVREQNAASMSQTSILVSQIIGNLLDLDPSSITDESDFFLLGGNSLLLGRLIFMIRKETGVSLEVSSLFVNSTVAKIAALIDEQSGSGGGSDPDDFYKLDEKGAGLYSSFNLAHTYDDSDPAFSSHGYKGRSQTHPLVIFVQLLPFLFFYPLKAAWTWTIILHGLAFFAYYIEDSFWQRIGALLCSIAIARVSSRVICPIGAILFKWVVIGRFRPGKYPMWSNYHLRWWIVNQSIRTSGRGVFALSPLLLKMYFRLLGMKIGSGVYIDSKTKLYEHDLITVHDRAQLDRCLVRGFCVERDGYFRLEPVVIGRDCVVNTYTYISPGARLVDGTVWGPQSSSHEAPSPDSYAAFNDASVRAPHFLLRFLIGWPIIILIRIVSYVPWYAALFLLLSQPFSVADSDSSDSLQTILAWYAYPHRIGYHIFARIIRKIFPPMINLVLGIIVKRILGLNSPGSMRNASQLALFRRWMTAQLLSQYRLKRAFEIIGTHYEMTSVVFRAMGAKIGKRVYWPGSGINCPDPELLEIGDDVVFGSRSEILTSDSISFDPIRINRGAMIADRVVILPGATIGTQCVMGSGALARRNGNYEDRSVWMGSKNGEAVSFGKSQGPSELGEDDTITPFGRAYYKRQANYFVMPYLMIVALNVFLQAIAAAYWACGFAATVVAINRIVEVYHSRSHWLFYDHWYRPAFLYLAIIIFFAVILPGQAIISLAWVVATKWAIIGRRREGKYNWDMSSYCQRWQVHLTLQKPAMQGFGGHIFNNLSGTVFAVWYLRCLGARIGKDCAIWAGGKPTLTLTEPDLVTMGDRVSIDDCSVVAHINSRGQFSLNRLRLGDGCAMRTGSRLLSGASMESQSMLLEHTLVASGEITESWAVYGGWPARRLNLRQAQPPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9M7</accession>
    <name>A8Q9M7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_3510</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729475.1">
        <property type="nucleotide sequence ID" value="XM_001729423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9M7"/>
    <dbReference type="STRING" id="425265.A8Q9M7"/>
    <dbReference type="GeneID" id="5853782"/>
    <dbReference type="KEGG" id="mgl:MGL_3510"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3510"/>
    <dbReference type="InParanoid" id="A8Q9M7"/>
    <dbReference type="OMA" id="MTAFPEP"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="279"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="402" mass="41745" checksum="DE1C38B83736CECC" modified="2008-01-15" version="1">MSFAKYTGKTQILEKHDDDVVICGAYRSPVTRARKGGLAQCTPEECLGVVFKGLIAKTGVDPKVIEDVSVGNVLPPGGGATGARQAALWAGIPNTAAVNTVNRQCSSGLASVTQITNEIITGQIDVGIGAGVESMTLNYGAGVMPVKMSDEVMSNEEAADCMMPMGITSENVAKKYNVTREKQDAFAAESYKRAHEAKAAGKFKDEIIPIKYVDDDGNERVVSEDDGIRPGVSKESLSKLKPAFAKDGCTHAGNASQVSDGAAAVLLARRSVAQKLGLPVVAKFAGAVVVGVPPNIMGVGPAFAIPKLLEKAQISKDDIDIYEINEAFASQALFSVEHVGLPLSKVNPVGGAIAMGHPLGATGSRQIATALSEAKRTGAKLIVTSMCIGTGMGMASLIVSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA36</accession>
    <name>A8QA36_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase III subunit Rpc25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729128.1">
        <property type="nucleotide sequence ID" value="XM_001729076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA36"/>
    <dbReference type="FunCoup" id="A8QA36">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA36"/>
    <dbReference type="GeneID" id="5853434"/>
    <dbReference type="KEGG" id="mgl:MGL_3595"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3595"/>
    <dbReference type="InParanoid" id="A8QA36"/>
    <dbReference type="OMA" id="LGPTLWW"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="7">
        <location>
            <begin position="83"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25811" checksum="DA7D11E334EEFD58" modified="2008-01-15" version="1">MFVLSEIEDVIKVEPRHFSRPSAKAIAEQINVKYANKVLQDIGLCICVHDILRSSEGRVRWGDGCLYYTVVFRLVVFRPFTNEVLVGRISSSTSESIRISVGFFDDIFIPPHFLPTPSAFDYQEQAWFWLLDPASEAHVADPLLSAQEERMYLDIGEVIRFAIESDSFYDLEPGPSLGEGMLGETPAVTSNFSGESGSRRSNFSSYKINASIAGQGLGLVSWWAGAEQVSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAA8</accession>
    <name>A8QAA8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729200.1">
        <property type="nucleotide sequence ID" value="XM_001729148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAA8"/>
    <dbReference type="STRING" id="425265.A8QAA8"/>
    <dbReference type="GeneID" id="5853506"/>
    <dbReference type="KEGG" id="mgl:MGL_3667"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3667"/>
    <dbReference type="InParanoid" id="A8QAA8"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="2">
        <location>
            <begin position="176"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="306" mass="35056" checksum="31E557677CA124F3" modified="2008-01-15" version="1">MRWLCAYPRSRAAMQDVVLWLEKTDERTELARAFSQALHERLLHPDVDTHAILVYYVNIVYALRIVDTSGVVLSRVLPPVQHYLRTRKDTIQAVVHALLGDDAAFELLRTELVHTQPAEPDVPGGGGYAVGAATAEEEEEEQYTRLEYWTDPTWAPRPVDAGPAFSHMRTRDVVGLLVSIFDDRQGFLHALEQHTAQRLVKTMDYDTSRVQRNNAIFKRRLGEQNLHHCDVMLTDVAWSQRFDTHFHAVAHGGMADHVHPMVISRQFWPDLDTRMYTLPKRLAEALEKYADFYAAQHPAKRCGRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBF1</accession>
    <name>A8QBF1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728912.1">
        <property type="nucleotide sequence ID" value="XM_001728860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBF1"/>
    <dbReference type="GeneID" id="5853218"/>
    <dbReference type="KEGG" id="mgl:MGL_3906"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3906"/>
    <dbReference type="InParanoid" id="A8QBF1"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="65" mass="7063" checksum="546DCF3CEAD9D6EC" modified="2008-01-15" version="1">MEDRPASALATDKKLSSEPTTPPANGFTAQKHDQAQDTDEEHASKATPSAAEDDEYINNPFDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC59</accession>
    <name>A8QC59_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728808.1">
        <property type="nucleotide sequence ID" value="XM_001728756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC59"/>
    <dbReference type="STRING" id="425265.A8QC59"/>
    <dbReference type="GeneID" id="5853114"/>
    <dbReference type="KEGG" id="mgl:MGL_3975"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3975"/>
    <dbReference type="InParanoid" id="A8QC59"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="39" mass="4411" checksum="BF2D4EAEC9C14423" modified="2008-01-15" version="1">MREQARKEAGKSHKDKVDSFNAYLDSLSEHHDMPKIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCF6</accession>
    <name>A8QCF6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">MGL_4003</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728836.1">
        <property type="nucleotide sequence ID" value="XM_001728784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCF6"/>
    <dbReference type="FunCoup" id="A8QCF6">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCF6"/>
    <dbReference type="GeneID" id="5853142"/>
    <dbReference type="KEGG" id="mgl:MGL_4003"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4003"/>
    <dbReference type="InParanoid" id="A8QCF6"/>
    <dbReference type="OMA" id="CNNCRPR"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="22">
        <location>
            <begin position="112"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="21">
        <location>
            <begin position="408"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="23">
        <location>
            <begin position="876"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EDP41622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="970" mass="109946" checksum="96733595D5DA7F30" modified="2008-01-15" version="1">MYGSTNEGNPVLVHVHGFLPYFYVHAPRGFTMSACPDLRNYLNTTFGGQCVAEVSLESKKNLMQYTGPENIAFLKITASDLRSLPRIRGAFERGEIAFRDLFVTGETCVSFDNIAYTLRFMIDHNIVGMNWIEIQANQYTLRSPNECISRCQIELDCSPSAIRSHAPHGEWLRMAPLRTLSFDIECAGRKGVFPDPNVDPVIQIANMVTRHGESTPFVKNIFTLGTCSHIVGCHVMSFENEVQLLEAWSDFVQRVDPDVVIGYNISNFDFPYLLDRAKALKVTTFPFLGREKNARSEAKDTHFSSKAYGTRDSKHTELQGRIQLDMLQVMQRDYKLRSYSLNSVSFEFLKEQKEDVHHSLITELQNSGPEARRRLAVYCLKDAYLPQRLMDKLMCLINYTEMARVTGVPFNYLLSRGQQIKVISQLFRKAREDGYLIPAYKGEGGDEQYEGATVLDPKQGYYDKPVATLDFASLYPSIMMAHNLCYTTLVDKHTIDRLKLVEDKDYVVTPNNNYFVCKTVRKGLLPDVLEALLAARKAAKSDLKNETDPLRRAVLDGRQLALKVSANSVYGFTGATVGRLPCLEISMSVTAYGRQMIEETKRQVEKHYTVKNGYEHDAVVIYGDTDSVMVKFGVSELEKAMQLGAEAAEFVSKSFVKPIRLEFEKIYFPYLLINKKRYAGLYWTRPEHYDKMDTKGIETVRRDNCRLVRTVIETCLRKMLIDRDVRGAEDYTKQVISDLLQNKIDMSQLVISKALAKADYAAKQAHVELAERMRKRDPGSAPALGDRVAYVIVKGSKGSAAYEKSEDPLYALEHNIPIDTRYYLDNQLSKPLLRIFEPILGARASSLLSGEHTRVLQVATSNVGALMKFAVKTVQCLGCRTPLKDQKAAVCMNCKPRETELYFEKVQRASEAEVEFSRLWTCCQRCQGSLAHDVLCSNQDCPHLLQAGSVPKWTLKMPTELYSVSIRHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCU5</accession>
    <name>A8QCU5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_4048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728881.1">
        <property type="nucleotide sequence ID" value="XM_001728829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCU5"/>
    <dbReference type="STRING" id="425265.A8QCU5"/>
    <dbReference type="GeneID" id="5853187"/>
    <dbReference type="KEGG" id="mgl:MGL_4048"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4048"/>
    <dbReference type="InParanoid" id="A8QCU5"/>
    <dbReference type="OMA" id="NEWISFN"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="490"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="898" mass="101424" checksum="7E899EB381CA3FF2" modified="2008-01-15" version="1">MSGRSQDCVRTPAALAQSGLMCCELTYTPLLKGATELQSVLPDPDATFCPDRMKWIACKRSEDPLHTPACWSDMATDIIDQGPIWYTEWRDPWLLHKNIKDLADRVVWKTREYDAALPMELWTAFKTSRERAPAPGHTPDSELARALSLLVRILGNALHGEKRPVPLDSKTFAQSLGWDPSLKAIMDHLGWHLAPLDEDMHRSALHPPSDTASCWPVYVELATWCAHLNGTPAAPEGMTWQIQPFISPLVPSNVARPDERIHFASARLGVSTEESAKRICDMYRLNSSCFPSRHQELFLALEYVEDVRHLGEPITTLMVMEQSQGMCTYKDVRASYERLGIPTPVVAPGCVSLWDEMPPPPPMAPDEALRAYNRAVHEALLHGTDEELRSARRALRVLARYHSPAPELDERERANPVQDPQDAYELLQTSPDIDDGLVLMGYEVYVNEAKSRAELLRMALEAIADARQSDYLHRFLRGEQESGSPVSLPRGLYNIGNTCYLNSLLQYLDWIRPVREAVRMACESASRNIASAQQERALTFAQLLDALFSTMASSNEPALFPSKELAYLALVPLVWEQAYDCTKDELMRQVTTQQDVCECLDNIVSLLDTACASEATQAPVRRLFSGASLQKLDPAPKDSSGTDGTKQTFTSIPVTILPGTRDVYDALDTFFNEEFVFLGNDAKVRREITLQEAPILLQIHVQRVQYDRTAQRIVKNQAALDLPDTIFLDRYMDLSLSKSERRPTLTLLHTRSQELRREKTKCTDRIQLLEDEHLTGLERAANALDSLQNTTLDDDELHLLLQEHSPEELMREASHMRAEVHQLRMQADTLRTELQGVWADERHVPYQLASVCMHRGEATHGHYFVNQRDFAKNEWISFNDTNVSTITGNECRESTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD27</accession>
    <name>A8QD27_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728760.1">
        <property type="nucleotide sequence ID" value="XM_001728708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD27"/>
    <dbReference type="FunCoup" id="A8QD27">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD27"/>
    <dbReference type="GeneID" id="5853041"/>
    <dbReference type="KEGG" id="mgl:MGL_4095"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4095"/>
    <dbReference type="InParanoid" id="A8QD27"/>
    <dbReference type="OMA" id="AYVFELK"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="587"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="880" mass="97801" checksum="CDE6650C6C530B1F" modified="2008-01-15" version="1">MQAHLSDLASEPESPHFRTCQRVYNRCQRILFEDPDPEMMIPDRHLLPLFHPFFEVRRKMWPGNTKTALAGMASAVLAIGRPDVAQYGQNLALQQGRLPPSDLIIHQPSRDASAASASSSVDHPPGEDTEHAVSSVHASSTPTSASLSTTAPSAPEKPPASLVSPSGAAGFPDDRHAPLPHEPPATFASAQQHDTKPDPVQQVFGQDDSGTPRNAAPLPLPQPLPSTPTTPSAPTTMPSHTTTTSALPPLNPNSHEYALHQKYLCSHYGRTEMQFLQALQDIPSRLQQLPKPARLSALRAELTSLNRTLPAEVCFPTWCAGSPAGSAHPERHHRVMRISASEAVVLNSADRVPYLLHVEVLRNDLDFDPNRRYNRELLHSILQNRDRSLRPLLMAHTKRPSIPRHPGALPDDPAPGDQQSGEVDLTEQMYGSDLSAFGMVHEDVGIQEEFGTKNDTLDTAAWAHASNANEQRADFSLDEYSQRMRTAAVMLAQLNKGSTLPRTAAASDAAEPGNEPAPTRVSYADAQVIRQRIMDEMTALEEQRMKRMKRGGQFFTRRKRNMMGAEDESAVLKAVNKDDPSAAYFRESWTIKKDRIRASSPYGSLPGWDLFSVIVKTGADLRQELFAVQLIHEFKRVWSECRSSCWVHYFRIVTLNESAGLIETITDAISVHSIKKAAYASQMAGQPISTYTLYDYFVQTYGDPHLPRFRRARRNFMESLAGYAIVSYLLQIKDRHNGNILVDADGHLIHIDFGFILGLSPGGVGFEAAPFKFPRDYIDILGGMDSDGYNEFKALMRQGFRDVRKHAERFILLVELMQRNSHLPCFAASDNAAAQLRDRFQLNFTSAQCDEFVDKLVLSAAGSAFTRLYDQYQNFTQSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD56</accession>
    <name>A8QD56_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_4124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728789.1">
        <property type="nucleotide sequence ID" value="XM_001728737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD56"/>
    <dbReference type="FunCoup" id="A8QD56">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD56"/>
    <dbReference type="GeneID" id="5853086"/>
    <dbReference type="KEGG" id="mgl:MGL_4124"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4124"/>
    <dbReference type="InParanoid" id="A8QD56"/>
    <dbReference type="OMA" id="MACEMEG"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725266" description="Carbohydrate kinase PfkB domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="4">
        <location>
            <begin position="3"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="296" mass="31297" checksum="E680AC9812589A7B" modified="2008-01-15" version="1">MWARPGGKGANVAAVLGLAGVQVKMLGAVGSDATWPIDCLKERHVDTTDMYVSPDVPTGRAFIQISSEDGENSIVLLKGANFATNTPLDEPNAWFSRNEQQITHLVLQNEIPLACTIAFVEHAASLGNVCTVFNPSPMLTPDELRAFPWSGIRVLIVNQGEAADMHRALSGRDAGSEPAKALASLPAFASIQWIVVTRGSQGSCAGVLVGSERVWVDTQAAKTRTVVNTTGAGDTYTGYLVAGLMSLHERDSLSSERIKAIMHRASVASAMAVEVDGAMESIPSAKEVDARIALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD69</accession>
    <name>A8QD69_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_4137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728802.1">
        <property type="nucleotide sequence ID" value="XM_001728750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD69"/>
    <dbReference type="STRING" id="425265.A8QD69"/>
    <dbReference type="GeneID" id="5853057"/>
    <dbReference type="KEGG" id="mgl:MGL_4137"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4137"/>
    <dbReference type="InParanoid" id="A8QD69"/>
    <dbReference type="OMA" id="ICRIWDF"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="54"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="311" mass="34997" checksum="C7E9E1006C8FC8F8" modified="2008-01-15" version="1">MCEAPQQTTPAATAETSIRASKEPARSPIYHDTQIWPDQHVQKSIQRVVRQVAVYFLRDCMTKDLLPAMGQLKVVQHILRAADAPYAYALERVFSPNHVVVCLSWLLTLFAHDVSTLRTAQRILDFAWSFGPASILYVCASVLLSQKESLHPRLYAMDVAEVHQHLSDAPRSLAADDVLADTLQKAASLMQQYPLTCPAVHAHHVLSCESVLFTWRAERVNIPMIMQLPTTHIALDVMPSPRDEVDFHSVVRSHLRPTWHRIFRELAHLHPMRRVLLYPKALFVSSLSLLLGGSVVTLLLAIHVTDHGRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDE2</accession>
    <name>A8QDE2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728714.1">
        <property type="nucleotide sequence ID" value="XM_001728662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDE2"/>
    <dbReference type="STRING" id="425265.A8QDE2"/>
    <dbReference type="GeneID" id="5853013"/>
    <dbReference type="KEGG" id="mgl:MGL_4193"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4193"/>
    <dbReference type="InParanoid" id="A8QDE2"/>
    <dbReference type="OMA" id="CREEREM"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="200" mass="23350" checksum="48C6F61947A55A76" modified="2008-01-15" version="1">MGLKNDGEFVNRMGLSRKHILDAVEASVKRLGTYLDVLWIHRLDRETPKEEIMRALNDGIEWGWVRYIGASSMAAWEFQQLRNIAERHGWHKFVAMENLYNLLYREEEREMIPYCQNTGVGLTPWYALASGTLARPWNGDSTERSRNDTIRGVLLGKGEEADKVIVDRVEEIAKKRKAFSWHKSIAWLLSKNCDTYSWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDG3</accession>
    <name>A8QDG3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_4202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000022">
        <property type="protein sequence ID" value="EDP41427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728641.1">
        <property type="nucleotide sequence ID" value="XM_001728589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDG3"/>
    <dbReference type="FunCoup" id="A8QDG3">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="GeneID" id="5852966"/>
    <dbReference type="KEGG" id="mgl:MGL_4202"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4202"/>
    <dbReference type="InParanoid" id="A8QDG3"/>
    <dbReference type="OMA" id="YWCTSYA"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="519" mass="57381" checksum="110F510F59E2E473" modified="2008-01-15" version="1">MKRVPEIDVEREISNDPFVTKEEEVYCSSVMENGTYHRGLFAGLLRIEAWLDKKVGVESEAIERKRPEDRKPIKWYEELNMAFLWASGTMNLACCATGMLGWEFGLDLKQSLLIIFFGSLLGSMGTAYCATFGAPTGLRQMSVSRYSFGWYPNKILALLNTVQQIGWSAVGAITGGLALTAVADGHISIVVGIIIIAAAALIIGLFGLRLIMIVERYAWFVFFVIFLIIFGETGKYADNHSPAKATGTTPLAGAALTFLAVVYGSSASWATIASDYYVQYPVNVNKYKVFLLTTCGLCIPTSIGMWSGAVMASALDNHPDWKQSYEQGGIGYLIRDILYPMGFAKFLLVILVLSGIAINLLNTYSAAISFQQISPWLAYVPRIIWQVVLFGIVIALGLAGREELNSYLQNFLSLLGYWCTSYILIILMEHSVIRKGSFDNYDLDGWNDKERLPHGIAAAVVFLVGVVCWVMGMAETWYVGPLAGLFGETGGDLANEFTFTFTLLAYLPLRLLELKFFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDL0</accession>
    <name>A8QDL0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000022">
        <property type="protein sequence ID" value="EDP41444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728658.1">
        <property type="nucleotide sequence ID" value="XM_001728606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDL0"/>
    <dbReference type="STRING" id="425265.A8QDL0"/>
    <dbReference type="GeneID" id="5852950"/>
    <dbReference type="KEGG" id="mgl:MGL_4219"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4219"/>
    <dbReference type="InParanoid" id="A8QDL0"/>
    <dbReference type="OMA" id="RNRDYMA"/>
    <dbReference type="OrthoDB" id="3361163at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42850" checksum="57434DFF99973B3D" modified="2008-01-15" version="1">MRRAHHDEPSSSSSPSMQSEDEEDVRADFLSEIDQQRFFQQLEVFQASSRVSPPAAVPETSRVSVPSTAPATNTGVTTATFVSPANFQSSPNQLSNSSCSNMPRSMDSSEFYSTAIQVLTHVLGSSKPHPWLSDQTLSHGEDPALSHTSTVSWDPKNSLASSPRDHAGHGIHASIDQFGASRSEPMRDKEQDLTQLLQTLLARGPNQTASSESHPQSEPVLAPPVPMPFADLAFPEDEDDDPDFMPVSSDRGGNELAMPSATAWTRAMEEMAPQESETSSTKSRRGRPRQFTSEEAAERKRDRNRDYMARLRTLRRQRRPYTPANSVDSRESSDRLVLEAENRFLRSEIERLQQENAKLRSREELRLYAAQFRMNQDHDGFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDR8</accession>
    <name>A8QDR8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000023">
        <property type="protein sequence ID" value="EDP41418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728632.1">
        <property type="nucleotide sequence ID" value="XM_001728580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDR8"/>
    <dbReference type="FunCoup" id="A8QDR8">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDR8"/>
    <dbReference type="GeneID" id="5852939"/>
    <dbReference type="KEGG" id="mgl:MGL_4231"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4231"/>
    <dbReference type="InParanoid" id="A8QDR8"/>
    <dbReference type="OMA" id="KICVLNG"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="231" mass="24758" checksum="3152C4486D01E35C" modified="2008-01-15" version="1">MSPVDDTFLSAAVDDSVRLWDLRSPAAQGNLRVQGHPVVAYDPSGLVFGIALNERSSILLYDLRKFDQNPFATITIDDTAALSQMMMPPRIPVITYLSFNQTGQYLLAGTSGDVHYIVDTFSGKLIYRLTGHVGLERADGASVGLVPKAGISGQELCWTPDGRMIVGGSAAGQVHVWALPDQPPATPPVTLHSTTTLQGQEGTPRVVAFNPRCAHLCTAGTQVAFWLPDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDX4</accession>
    <name>A8QDX4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000024">
        <property type="protein sequence ID" value="EDP41403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728617.1">
        <property type="nucleotide sequence ID" value="XM_001728565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDX4"/>
    <dbReference type="GeneID" id="5852929"/>
    <dbReference type="KEGG" id="mgl:MGL_4242"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4242"/>
    <dbReference type="InParanoid" id="A8QDX4"/>
    <dbReference type="OrthoDB" id="3349465at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725269" evidence="1">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="217" mass="23831" checksum="238E763AC49EE8B9" modified="2008-01-15" version="1">MRMQLGSVMAVAALSGLVYGAPAQNGRCHPVAKPGPLVGLGDYEDTSVQQLSFGAAKGYKGHVLVASDDAGEALQFYECEPPSDKYEGSNDYWYYGQVRSKNDPSLCLTPGTVNRPIKGSKHKWEAYPEDGEKAVRMEPCAQEASLTMRKQWFRIPRTGPKGCSRELDQAGWKGDELSLRLEYDGGSPVTFGVTTRDYARILMLNSGKAEHRCINAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR31</accession>
    <name>A8PR31_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732812.1">
        <property type="nucleotide sequence ID" value="XM_001732760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR31"/>
    <dbReference type="STRING" id="425265.A8PR31"/>
    <dbReference type="GeneID" id="5857118"/>
    <dbReference type="KEGG" id="mgl:MGL_0587"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0587"/>
    <dbReference type="InParanoid" id="A8PR31"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="65"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="380" mass="43150" checksum="254CE66E7FB244A3" modified="2008-01-15" version="1">MCIRTRSRRAATMPDTVLKATDVAKRSFIPDTDALTSLKSAKLPKLQAKSESCARKPRCASRASQRRTEHSVIERRRREKINDQLICLQCIVPACREQACACVQKRAKSTTSPLFVGDDDNVDGYISTHVVLEKLCIISHALDYVMELRAKLQVYERQGHDHAARRGTGSLDTIAQDSDMPAYDDKNQLSPGYKNETLHHHTSKLAQIDSFTPKPTAALDHPLHLDHDRLGDGHLLRHANHHLLLHNCPTPYVHVHDHVTHGAQIVNVLSALDQDPSPKSPQHHYHHFHHHHKPGCRAWQQPWIPWHVRASHIQTCRDAPVHAAAAQDSLASSQHRTFPNAWPLRYEHHSWDRGPSYLDTLCRPKRDPVQHASIHHHQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRL1</accession>
    <name>A8PRL1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732302.1">
        <property type="nucleotide sequence ID" value="XM_001732250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRL1"/>
    <dbReference type="STRING" id="425265.A8PRL1"/>
    <dbReference type="GeneID" id="5856608"/>
    <dbReference type="KEGG" id="mgl:MGL_0077"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0077"/>
    <dbReference type="InParanoid" id="A8PRL1"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="471" mass="51717" checksum="FDEEB05D2FF051B8" modified="2008-01-15" version="1">MSLDLATWGISTSEQLVQALKRSEGYKNRQPNAAGGVPTIKILQAAWIDNAVYIPRKAELLLECILEVLTMSAKNPAKLGTKYLEVSYWQLLEHVLVGLRAQHDFLHALVSKHNILVLVSAVTQNASIDVWGAALPVLKVLLPVSIRRIGASQIELINACFRDLIKALPRACTLATMHLMVTLFDAIIKPWYSDVELGVNAKKTAKNFVSEILCPYAAARIHVGSFGTNEASVLISQLDYFATVSLYGPQRLGGKPSGSLPDSVDTLVESLTALLKSSSTSTDICEILSPLLYNLVEKVSPSSERAQAPPAHTRHAVLERFLLPIMTSLLPSSHTLPTVLSLLRNIDEAALYQPGGEDQDTWLALWAKLVTYTLKESESPQLKDRPECFLTLHALWNICTDEVAPFLSVVLTRISQVSLGEPAWEAAINLNHAILSHFAAERRMPRLVEFLCETLHHMCRESPQACGPVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSE5</accession>
    <name>A8PSE5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0243</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732468.1">
        <property type="nucleotide sequence ID" value="XM_001732416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSE5"/>
    <dbReference type="FunCoup" id="A8PSE5">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSE5"/>
    <dbReference type="GeneID" id="5856774"/>
    <dbReference type="KEGG" id="mgl:MGL_0243"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0243"/>
    <dbReference type="InParanoid" id="A8PSE5"/>
    <dbReference type="OMA" id="MHCASPQ"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="129"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="142"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="223" mass="24627" checksum="3CB8B88FF9117C59" modified="2008-01-15" version="1">MSRAFEKVGATGLGRLGLFQSRAMIQQREASNLLGVHHMAVTQYLSEQLARASSIQASLQQKRVDMQRQRYEKLSDNTPQSISTQTGSALPAEALQGSIGAMGQQGVDVVDQLSTEQRQVFEEEASALVQSLQADLAAVQHAEQQLQDISSLQTKIVQHLEEQNEHVDTLLSDAGTHGEQVTRGNQQLRRAKERNRQANRLLSLFFVLSGLLLLLMHCASPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSW8</accession>
    <name>A8PSW8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732554.1">
        <property type="nucleotide sequence ID" value="XM_001732502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSW8"/>
    <dbReference type="GeneID" id="5856860"/>
    <dbReference type="KEGG" id="mgl:MGL_0329"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0329"/>
    <dbReference type="InParanoid" id="A8PSW8"/>
    <dbReference type="OrthoDB" id="2554945at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="250" mass="27526" checksum="BD4DAA31F2BDE921" modified="2008-01-15" version="1">MTQSNRVQRQEKDEADGDDDGGGEENEKADEPEALDPALFAAAFARTGDAAARDVLTKHKVGRRPRKARSSESSIRLPGERTVLRTWNDEPEHEDLTDAPLQHTPLDPHHSMPSARERGYKKRKLGLRSKDVRANPIEKPRRPRRTKAKSKTTDPDDPLGLQDPAFMPGGEFFHLTGRPTSKRQRAGQRIGHDLAIRERGAGGRVQGTYAKWEDGQLPAAGVPTSDDTTTASHTVFYTLVGLPGSQPAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUC0</accession>
    <name>A8PUC0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732055.1">
        <property type="nucleotide sequence ID" value="XM_001732003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUC0"/>
    <dbReference type="STRING" id="425265.A8PUC0"/>
    <dbReference type="GeneID" id="5856351"/>
    <dbReference type="KEGG" id="mgl:MGL_0648"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0648"/>
    <dbReference type="InParanoid" id="A8PUC0"/>
    <dbReference type="OMA" id="HHMKAKP"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20866" checksum="0980E0DDC0A00A0B" modified="2008-01-15" version="1">MAHPMNKFNAAGLMPEHSMNLPVRAASSPDENLIIHALMSMPAMSDEDLSKVFAPEIIYTAPNGQVLVGKIAVSAYLRANMQPDSMNLLETPSLLPPQAMVIDMHMPSGKRHLLVLKRRVQDGLVSTMTDEEGHCKTWASLAVRAASSSIHSPTDTMVSPCTSKLSLAKRRHHLKAKPTTLFAGMRDQQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUD6</accession>
    <name>A8PUD6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732070.1">
        <property type="nucleotide sequence ID" value="XM_001732018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUD6"/>
    <dbReference type="STRING" id="425265.A8PUD6"/>
    <dbReference type="GeneID" id="5856366"/>
    <dbReference type="KEGG" id="mgl:MGL_0663"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0663"/>
    <dbReference type="InParanoid" id="A8PUD6"/>
    <dbReference type="OMA" id="FGSCTES"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727874" evidence="2">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="258" mass="27892" checksum="7ADDA4ADFECF11D3" modified="2008-01-15" version="1">MYIPRIWQALFIVLVTSQLALGDDNSLYLSPSKHGGSMLTKQKEPLNVIISATSDSSVLDKEGFLQFANATGFELDENAGKSKNNGAQSANLGDGRGEVEQDGLMRAKPALAEVVNGGNHFRFWMQTGDKAKTNAIFIAASVEKSIKQNHDIVKNGYDMGRDQLVKNATQQDRSANGKTFRTKLLKMDSSLLNDISKNNLNHNIGTDGRVAILEVKVSDDTKSGSGKSGQNYGVSVHTRLSIFKALAVGAFVGLVIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUG2</accession>
    <name>A8PUG2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732086.1">
        <property type="nucleotide sequence ID" value="XM_001732034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUG2"/>
    <dbReference type="GeneID" id="5856392"/>
    <dbReference type="KEGG" id="mgl:MGL_0679"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0679"/>
    <dbReference type="InParanoid" id="A8PUG2"/>
    <dbReference type="OMA" id="THICTIA"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF160">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="335" mass="36612" checksum="003FE639E3534AC0" modified="2008-01-15" version="1">MSHIKRQQRRWVSLLGSVIIALSAGSTYVFSSYAPQLQEALHLSSTQLNILGLAGNLGMYMSGPVWGRWIDQAGPYGAVISGAFLVLTGYGMLSRAHKYAWTDMPVLMLSFFCLCTGLGNSAGNNAAINVQAKSWGEDHRGSAMALVLSAFGLSAFVYSTLSHTFFTGNVTGYLDMLALGSFSCFIVGMMLIKIVPPSEGEQAQQTASSSQYERVPDREDPERDAMPGRKPLRRMRSSSETSARVIAWIRDVHESEYGHADDDQVIDERDPGTTDITGLQLVRNVDFLLLFTILGFLSGSGLLLINNVGTITRALWDHAERENRLVVGKTTTDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUQ4</accession>
    <name>A8PUQ4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732152.1">
        <property type="nucleotide sequence ID" value="XM_001732100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUQ4"/>
    <dbReference type="STRING" id="425265.A8PUQ4"/>
    <dbReference type="GeneID" id="5856458"/>
    <dbReference type="KEGG" id="mgl:MGL_0745"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0745"/>
    <dbReference type="InParanoid" id="A8PUQ4"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="317" mass="34914" checksum="8D36B59B28267125" modified="2008-01-15" version="1">MNPLAPQLRSMFAPTTYPTSGSTSALRRAATCDILSFVARFGICTPDVMRMLERLVIRSKWCGNICQLYGIFATMPEGTQALVPTRLACHAVPERLFRHSVVVSMPSYLDGTPALEHGLLLSFVRHVCDLTPVGMPESEVRLPPLSDLELIARMILLHRASPNSSQGYPLAMAVHLDSTPLVCLLLATGADPSLKKSIALHVACKKGSLAVVRLLVEQDDALEFQWRTRLRAIVDDLHALDVVRATRQEPPRARRSLPEKGAVPSKRRRLADRCQVDVPMLTTAVRAGAWDAVSYLMQTKGVVPDVSTLRMMDQKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUT0</accession>
    <name>A8PUT0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 12">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0765</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 12"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732172.1">
        <property type="nucleotide sequence ID" value="XM_001732120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUT0"/>
    <dbReference type="FunCoup" id="A8PUT0">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUT0"/>
    <dbReference type="GeneID" id="5856478"/>
    <dbReference type="KEGG" id="mgl:MGL_0765"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0765"/>
    <dbReference type="InParanoid" id="A8PUT0"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP44958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="359" mass="39555" checksum="952B7550496506E4" modified="2008-01-15" version="1">MNDASHPRRRFVRSDSTKDEGPMMGGIPTSVLEDPLLNVAIDSLLPKHYNFEIHKTVHQIRKYEATCVALQMPEGLTMFATAIADIIERFTGAASVIMGDVTYGACCVDDYTALALGCDMLVHYGHSCLIPVDQTMIRTLYVFVEIQVDTTHLYQTIRVNFPADRACFRQRVLTSPYEQATHAALPVQAQEPTTSKKQPTHIALVGTVQFIGAIQAIREALTTCPSEDDISARKAIAPKEESEIAGAEHDNSIFGTSGAHGAFKASVPQIKPLSPGEVLGCTSPKLDASDVDAILYVGDGRFHLESIMIANPRIPAFRYDPYTKRLQRELYDHAEMRRLRKKAVLEAQATLEDASLPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUU1</accession>
    <name>A8PUU1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0772</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732179.1">
        <property type="nucleotide sequence ID" value="XM_001732127.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PUU1">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUU1"/>
    <dbReference type="GeneID" id="5856485"/>
    <dbReference type="KEGG" id="mgl:MGL_0772"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0772"/>
    <dbReference type="InParanoid" id="A8PUU1"/>
    <dbReference type="OMA" id="AQWAFGG"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="914"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="998"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1049"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1060"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1082"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1161"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1232"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1357" mass="144546" checksum="EB7E0F8DED63F1DA" modified="2008-01-15" version="1">MKAYLPRTAAFAWAPSNAEVSGPVMATGTVAGALDESFNNDSVLELWHLNASADDTMNLSPTMASSVNANGRFNRLGWGFAHKDKPYGLLAAGLENGEVGVWDVGLMLDPHTTAQSQVLRNSMHKGSVRGLSFNQPQPNLIATGSVNAEIYVWDLKAPNKPYTPGSRSQHLDEISSLAWNGQVPYVLATASTNGCTTVWDLRHKREIAVLRNNSAPAAAAMSSARSISALAWHPLSPTRIATATEDDMNPGIVLWDLRNSRAPEAVLSGHEQGVLGLSWCRQDENLMLSCGKDSRTLCWNPQSHEIVAEMPPRSNWAFDVQWNPRNPNMLASASFDGHIIVQSLQNIPTEGEQDAGAVSTANMNPDDLFTALGNAPPPTTGGVPLKTAPKWLSRPTSVAFGFGGQLVTIPKTAPHGAQSFPITIHAVHTEPHIAERARDLSEALDANTLVDFCVAQCQNPNTRPSDMASWKTLQTLFHVDSRDELVELLGFSRDSVSAQVQQAVGALGLPVLEDEAPTDQVNAPLTDDTVPAQDEDPAAFFDQVPAKPLTPPPPPAEPFRLHPGGEHDPDRLITKSLILGDFENAVSLLVSQDRFADALVLATRAGDELLVKTQRAYFKRHASRLPYLRLLQSIVTEDLTDVVQNADLAEWQEIFVVLCTFARQEDFSSLAERLGQRLEDRYLHSVQNGQRTTEAMDDRKNAVLCYLAAGCLEKVMSMWIEEMREEEHAIKAGSIQSDSSPYSAHAEALQTLMEKVVVFEHAVQYTDEDLQLPPANPDGTMPVREFKLAPLYNYILEYVNVLAEQGLVDIALKFVALTPPDFTPHALSALADAEWTHDRLLRASQASSYGQPSTNPYVQGAYGQSAYGAYSAPSAPSMATAASMPSIPTVPTVPTVPTVPTVPTVPTVPTAAQTLAPPPTVQQQRSRQTPPVAQIPPPPPHVGMGTTTSTMPMAQADSSSSPYVPAYNTAAVTPAQPPQASAYTNTAPPVMQAPPPPPIIGAPTAGMPNLMPETQAPSMVPPPPLQREKGGWNDVPAATLPPPPKRVPSAASSTSAITSPFPNQAPAGSTPMSTAQGGPGAGPMPPPPPPPRGPPMGGPPRPSSAASSHVPPSPRSGLGLGQPPRAADYGRRMQDGMQNAPGGVMRPQTPTVPGRPPMARTPNTLRPQMTGPPSQFAGQQAAAGATPRGFSHGSGMPMTPRAMGNGGPPQARGGRPGPPPRSMTPAGGGYGAPPSTSTPGTKPGFQYPRGDRSHIPPHLKAVSDSLIREVARLRSIDAQPRRILDDADKRVQLLLDLMNNGLVDAKLVPVLQQLGKAIDARHQQGALSLHVQLVTMATGDVATALVGVKFLIAKLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV82</accession>
    <name>A8PV82_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731553.1">
        <property type="nucleotide sequence ID" value="XM_001731501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV82"/>
    <dbReference type="GeneID" id="5855873"/>
    <dbReference type="KEGG" id="mgl:MGL_0821"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0821"/>
    <dbReference type="InParanoid" id="A8PV82"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="191"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="270"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="339" mass="39037" checksum="4F508ABC3D403C0B" modified="2008-01-15" version="1">MISALSRAKDTCAKHFVRLQQALVVQGSYPTELLQAWDTFKEENANRSENVRPDVLSSTQLYVLIVMDDAGKDLECTPIASWMERAAAFWQVACAVAVAERATAFEHRDLHLGNILVQRVDKQENLDQIEVYHREQLEKNTMKQVRHMTHIDQILTMYEPRRTGIHATIIDYSLSRMELGKKIIAYDFSDESLFSGQGDTQYDVYRKMRSLVADQWTAHVPMTNVLWLQFVLQRLLASNAPPREETEHESETKAYDLLVHAEQLAHEALENERRQQLPQRRMSTRSKRRSTQRARDALQSTPDKMVPTFAPPPRITSAWTWIEAVVAAAFEEDVEDLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV95</accession>
    <name>A8PV95_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731557.1">
        <property type="nucleotide sequence ID" value="XM_001731505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV95"/>
    <dbReference type="FunCoup" id="A8PV95">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PV95"/>
    <dbReference type="GeneID" id="5855877"/>
    <dbReference type="KEGG" id="mgl:MGL_0825"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0825"/>
    <dbReference type="InParanoid" id="A8PV95"/>
    <dbReference type="OMA" id="VCARSWD"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="223" mass="24474" checksum="B35AA6DCB436F576" modified="2008-01-15" version="1">METIYLPAVFPDDYRCVYIAQFDHVKNGSELRHALVQASKTPVHSDERRRMDMAFVDARLVCSRQQLITAILQAIVGAQRRDIKREELEPLAITGLKTPSIHSDILWTLNPNNNIGDALRRFGVSAATSSLLLVHVAKAPPEGPQPQAVAQQMNDLVDGTLLHGIALSMDASSDATGDKIPAEAWKDVGKTYKIQDAPAYLQHDTQQVNACICSMVASKYVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVN4</accession>
    <name>A8PVN4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731647.1">
        <property type="nucleotide sequence ID" value="XM_001731595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVN4"/>
    <dbReference type="GeneID" id="5855953"/>
    <dbReference type="KEGG" id="mgl:MGL_0915"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0915"/>
    <dbReference type="InParanoid" id="A8PVN4"/>
    <dbReference type="OMA" id="ESQAHEF"/>
    <dbReference type="OrthoDB" id="3346227at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="178" mass="18590" checksum="DC178029EEA5DA9A" modified="2008-01-15" version="1">MSSQSNNFGAQAQQFGDEMSNKMQNAANEFQSNSQSAKAEGKDLLDKAEQKLPEAKEQGKSLLEQGQEQLNKATDYVKEQSDQLANRGAEGAESGQSTFAQISEQAQKYASDAMNSVSNALHGAGDKASDGATKAAEGTSKVGPNDSYVEAARKTASDTISSVQNYFSGSSAGSGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVQ6</accession>
    <name>A8PVQ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731662.1">
        <property type="nucleotide sequence ID" value="XM_001731610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVQ6"/>
    <dbReference type="STRING" id="425265.A8PVQ6"/>
    <dbReference type="GeneID" id="5855967"/>
    <dbReference type="KEGG" id="mgl:MGL_0930"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0930"/>
    <dbReference type="InParanoid" id="A8PVQ6"/>
    <dbReference type="OMA" id="IVEYKHI"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF530">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0271350-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="472"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="544"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="670" mass="73046" checksum="3C2B048DDE95A90E" modified="2008-01-15" version="1">MNASGTNEPPQGVVAISADELVVRLGRILQGSGPNDEEVVTQQQQQQQQQQQQQHKTQSHQELPSQPQQQQLPNIDCCDACTETNSQNERQGSWDTDAILTHPSNSPAPKSSHEKSWIHAAPSDPPTSKSSVSMPGSPALSATRINCAAESYPPLPFVAHSHEPMLLIDTRPAHMFQGCHDSSMDRNLCTGHLKGAINVQIPTLLLRRSQRALGASPALLDSIDIASYIHTDADKQRFRMVCHSQLASAPSGVEPSTITELVRALWFIDVVVLYEHDKSAFAGHLFLRILSAIRARAAAHAEPHLASLRRGLYFVRGGMRQLREDAAYAAYFEVGDVPAAPGNDNGNGHDIDSGSTVSGSRADTHGGSANVQDVAPDSLRLGTPAIDASMLTKQMGTFDLSAPPPRRPALPRIDTTIQHVPDTVDPPWRNSGIDVPLRLPLTASLHVSTDYKGPLMDEPQTAHIISELSEFEVSTIVPGEVYLGSGVQKPSDMEKLEQLGIKAVLNTAAEVPYLHDASPLRHHPHIVEYKHIPMRDVVEAVGVQQHLEEACCFLEQMCSRGLPTFVHCRAGKSRSATCVIAYLIKTRRWSFKQAYAFVAARRPRTSPNIGFIAELMHFERVVLGTGPAMSSCLPLSPRKSLPCPPESLADGPTHLRDAVSPWRTRSPPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVT5</accession>
    <name>A8PVT5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Muniscin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731683.1">
        <property type="nucleotide sequence ID" value="XM_001731631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVT5"/>
    <dbReference type="STRING" id="425265.A8PVT5"/>
    <dbReference type="GeneID" id="5855988"/>
    <dbReference type="KEGG" id="mgl:MGL_0951"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0951"/>
    <dbReference type="InParanoid" id="A8PVT5"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Muniscin C-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="229" mass="25341" checksum="C9FECD41B2B5A06A" modified="2008-01-15" version="1">MSAVYTPALVQTKSVASVPHTPVPIQVHLYERVNAIWQRGRLDHVMVVGEVRVSAGPLSSSLTSFTSSTSKPEPVRILLRLLHIEAMAQTRLGSLCTRTKEPDLFELQLLESAEIRALDYQVHVPESEYDRYLPLLLQVQWRCEPTQSSALLMHRTNPAMPCGDRLEDVSFQLTLPADTQVTGGVRSEPVGEWGPPTPDPFLGVPPRSMARGARPLSPLLARYASARSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVY5</accession>
    <name>A8PVY5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731717.1">
        <property type="nucleotide sequence ID" value="XM_001731665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVY5"/>
    <dbReference type="STRING" id="425265.A8PVY5"/>
    <dbReference type="GeneID" id="5856022"/>
    <dbReference type="KEGG" id="mgl:MGL_0985"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0985"/>
    <dbReference type="InParanoid" id="A8PVY5"/>
    <dbReference type="OMA" id="CKTDYDR"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="126"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="209" mass="22960" checksum="1352924AB869A629" modified="2008-01-15" version="1">MYHRHCLKCVVCNRRLDSVSLLEHDGEPFCSNCHRTHLGQGKDRFGTAVPLKPKIPILTSQNPPTTSHCKPSQPPPSKANSDTNISARKPLPISPSGSQDPLPIPASLSMQNVVPLHGPPAVGQTPLCGRCQTPVYFAEQKHAANRKWHRACLRCEGCRASLEPNRVEEGPADLWDQGWVNTWCHMCYSKKFGPKGIGVAGMSYPTPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW06</accession>
    <name>A8PW06_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methionine aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731731.1">
        <property type="nucleotide sequence ID" value="XM_001731679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW06"/>
    <dbReference type="FunCoup" id="A8PW06">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW06"/>
    <dbReference type="MEROPS" id="M24.017"/>
    <dbReference type="GeneID" id="5856036"/>
    <dbReference type="KEGG" id="mgl:MGL_0999"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0999"/>
    <dbReference type="InParanoid" id="A8PW06"/>
    <dbReference type="OMA" id="SIKRPDW"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="74"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="272" mass="30335" checksum="92AD0FE119FACD46" modified="2008-01-15" version="1">MVDKPELYDPFQKVRGFKYTGSLRAVYPLSPKTKIPAHIRRPNYGREAVSMATAHLKLFPSRRIRVNTTEDQEGVRKVAKLARESLDHIAAMIRPGITTDALDEALVQASIERKCYPSPLGYHGYPKSVCTSVNEIICHGIPDQRPLEDGDIINLDVTLYHNAGYHGDLNATFPVGEKARESEPLMRLIRTARECLDAAIAICGPDMPYAEIGRVIEPIAKANGCCVVKEYTGHGIGRVFHGPPPVYHYPTKKSYGTMRPGHIFTYGVFHCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW28</accession>
    <name>A8PW28_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731745.1">
        <property type="nucleotide sequence ID" value="XM_001731693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW28"/>
    <dbReference type="STRING" id="425265.A8PW28"/>
    <dbReference type="GeneID" id="5856050"/>
    <dbReference type="KEGG" id="mgl:MGL_1013"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1013"/>
    <dbReference type="InParanoid" id="A8PW28"/>
    <dbReference type="OMA" id="CLEVHGD"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="424"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="464"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="544"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="636" mass="69858" checksum="0484211251F4AD5B" modified="2008-01-15" version="1">MNVSSPLEQLLQSFAVATVSDRRAFLEAVVRQCNVRELSELEALLLPRLKVDFLHRLPMEVALHVLTFLDDPRSLASTAAVSRAWYRLSTDEYIWGLMCVRHAFHTPQRLRWMTTSLLTPSAWSDADGTAHMRMCANGHHSNNGSHASATKRHDVSAMDVDEGGSRLRRRRSFFADVGAMPPPASAASVSLREYFRLAYMVQQEWLRGGRVLRSYETTELADADPDPNRRLALTCCAMDEEWIIAGMTNSTIFVFSSRTGKLERVLRGHESGVWCLMLATGTHDAAGADAMPLPPASAADDGRGELVCVHADRRPSVHLSLEQHGGLAIHDAAYVAQQSADTDVACARTRGWGQRGTRLVSAGSDRSLRVWNVHTGECENVLRGHTSTIRCVHVVAGQPVAVTGSRDGTLRVWDLELGQIRHVLAGHQHSVRCLAVQGNVVASGSYDFTCRLWDWTTGRCLHVLKGHQLQIYAIAFDGVYVATGSSDSTVRVWDAATGAALAVFHGYTHVVAQIQLDGNMLATGSSDGRVIVYSLATMECMYRIVAHESGVTTLQMNERYLVTGGSDGLVKLWDAQSGRYIRTLCEPCGAIWCVRFMDDICVVLGKRHGRCAVDVVSFRPPALYKSTQMGEQQLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW48</accession>
    <name>A8PW48_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731757.1">
        <property type="nucleotide sequence ID" value="XM_001731705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW48"/>
    <dbReference type="GeneID" id="5856062"/>
    <dbReference type="KEGG" id="mgl:MGL_1025"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1025"/>
    <dbReference type="InParanoid" id="A8PW48"/>
    <dbReference type="OMA" id="TESMKAN"/>
    <dbReference type="OrthoDB" id="3366874at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="679" mass="73168" checksum="ACF236233408D16C" modified="2008-01-15" version="1">MSGERVRESLYAFRQPQTKPHLALGHGYSPNTSKSVLYTEKPHSFSTPSLVRIASASPLPQRAVTPTQPSPTRRATPLQPLHDTPTSSSPGGWIRRLRKSRSATTLSSRKWNSKPRSPAPQSANKSTRASPIESQIQTPSRMPTNDSIPGSSQRATTRSIPSCDLSLSPASSLHQLSYSMEPNVSLGNTNGNVGLSRPSQDVMQYGVDCDTSHMSFNNSTMSPTSSLVEEEPRPAFSSSQTPEADELFGATTHGVNVMKPNRPSKASISNALLLEDLPRLPYKQTSSYARKSWTDPAARQRAGSEPSINDLKSVSPMAPRVVCVDQASSSQVSPLHRGVPLTISSPHLKHSQEVPSPTSTVSPERQCLFNVTPSPSTDFDSSKCAPDPFARRLPVRPQSPANDPFISFSPHRDHDGSGADQLPSNVTPATENTLRRPSCDQIREPPLVPGRRNDSQSEASTTASMSRQEYLRPSFQTSGDPSSSPSTSTSVHMTPVDFEHAAPIHIDDMLQSALNEASTSATSTPAGFSDRKIAPTNSGTSSNPKTHLAHNGSSEADKELSPPSPTSTKATNPIDSMSIRIEQFQAQQASLRGSIESSKMEIVRLREQIRAFRKEVGGECDVDSAALSNAHADKGGSDLLPSPSSLTPGQHLRLRDSLSSMDDLDRRLSDMLASHATVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW60</accession>
    <name>A8PW60_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_1032</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731764.1">
        <property type="nucleotide sequence ID" value="XM_001731712.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW60"/>
    <dbReference type="GeneID" id="5856069"/>
    <dbReference type="KEGG" id="mgl:MGL_1032"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1032"/>
    <dbReference type="InParanoid" id="A8PW60"/>
    <dbReference type="OMA" id="ISHFYQF"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="14">
        <location>
            <begin position="101"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="15">
        <location>
            <begin position="458"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="13">
        <location>
            <begin position="902"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="16">
        <location>
            <begin position="1053"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="17">
        <location>
            <begin position="1250"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="327"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="626"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP44550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1518" mass="167893" checksum="51C525B8C7450580" modified="2008-01-15" version="1">MDAKHSVHADTAGDWSADACRTVAQALTSSLDLGLYRDAIVDTMVWMHVVAADLGERVRTWTGRQYHRSPQHILAMLHSFSAIMREQYEQLEDQQRFRLMGLEKLHATVAQVEDMQALLSTKRTRLEAANVEANDRLQLMVQQQQAAETKREASIALQSALQQQEADMAQQRASVLQELSEAEPALLDAQAAVSNIKKQHLSEVRSMTNPPAPVKLTMESVCMLLGHRIDGWKTVQSLIRRDDFISTVVHLDTASIPHALRERLQREYLNRSEYNLESIHRASTACGPLARWVLAQVHYAHILERVEPLRAQVHTLEAQAADTRLEASRADTTVAELENSIAEYKREYASLISEIQALTNELQAVEARVARSVRLLDGLSSERERWEQGRQTFDAHMQTVAGDSLMCAAMVAYAGFFDQACREALWRAWLARLDAVHVPVRRTLSFADTLSTADERAAWHDAMGLRSDALSIDNAVILQRCTRVPLLIDPSGHAVSFASALYACAQPAVTSFLDGGFVQVLERALRFGTPLIISDAEHLDPVLMPVLNAEKRRTGGRTLVRVGTADVDWAPSFCLVLTTRYAGVVLPPHVFARVQVINFTMTRKSLEAQALSKILHYERPDIEAQRADLERMQNEFKRRLLRLEHALLTALNEAQGHILEDDHVVSTLETLKAEADDISRKAASTESIVRSVAEATHAYEPLASACSALYFLLEHMQSLHAFYAFDMRLFERLLTDVLSHRSFAQDTESRRHALYDTIFVATYRRAAPALLHADRLVLAIALAQLYCRAGPRAGALDGADFFSLLHGSDTATLRLAAHDEKAHPDAWRTWTSQATPELIESPLPHAPDDEIGASVRQALLLRTYRPDRLEPALVRLVHHVFGAPLLDMPLLPLQDIVEQVSSDTPLALFGVAGYDASGTVESCAASLNVSCAQVALGSPEAMALADRAMASAARSGSWVLVKNAHLAPTWLAQLPARLAALCPHERCRVCLTCELSPSVPPAFVRAARIVMHEPPAGCKSILLDALHALDMRDVLGAPTASSAATPPPPERERVYMLVAVLHMMVLERARHVPQGWSRPYEFYDTDLDAAYTLVDTCFAHAAQTKRHLAPEEIPWLALRTLLAQDVYGCRMDSEADRKMLDALLAHLFTPAAFESEFVLAPDLVQPLCAPDGVRRELFRSWAAALPEPQPVSWVLLAPAAERVTAAQHAIRALQRLQTVRQCAEREQDIVIEHASLDQVPQPSVPAMTTELAAFVDTYLAKLPSVLAGPTAGSAEFGAEADDPLGRFWARERRTAFEFGSLVRADLVRVSDILAQRAPRTSPMAALIALLEQGDVPVSWRRGSSVPLGSTLRAWLDDLCARVHHATLPIHERVELGQLWSPSAYLTAARQMTTRETHASLEQLELHWVLDSGSAPPHSLKDAAWWPIGSLWLDGGVWKDGCLHLNDGASTSVSLNALLWTCRKEADSPPQSSEPFPQLSVPVFLDAQRQHFLCHAHIPIAKDASMELAVLHAVAIRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWH4</accession>
    <name>A8PWH4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731833.1">
        <property type="nucleotide sequence ID" value="XM_001731781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWH4"/>
    <dbReference type="GeneID" id="5856138"/>
    <dbReference type="KEGG" id="mgl:MGL_1101"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1101"/>
    <dbReference type="InParanoid" id="A8PWH4"/>
    <dbReference type="OMA" id="HPRCAVI"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="309" mass="31931" checksum="7533472A1B0D542E" modified="2008-01-15" version="1">MPPMSSSSSHSAEPRAPAWDDSDSVSVQGARRTRERGDGANTATSRPSSGVGAAAVAAGSTAVPPRKPVSDTKRTPSIRPKPDWQRSSKAMHRSSTWDSTRPASRPKTFVDEGTSPGLPSSPVDEVPPVHGISQNTPVVMPEPQPALDRPHTSVSSLKGATTAQLSDMLAHQRDGRVRLTRQASRSSTGPPARQRVISPLASQVEMTESSKPPKPATTTAGTAAAAAAAAAAAVAANATASTATPTPESPDPSASPLRSATPKPSSHKTSRPDALSVMEQADKPASDQASESFQGVSALINKWQARPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWJ7</accession>
    <name>A8PWJ7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731856.1">
        <property type="nucleotide sequence ID" value="XM_001731804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWJ7"/>
    <dbReference type="GeneID" id="5856161"/>
    <dbReference type="KEGG" id="mgl:MGL_1124"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1124"/>
    <dbReference type="InParanoid" id="A8PWJ7"/>
    <dbReference type="OMA" id="YWRRSFE"/>
    <dbReference type="OrthoDB" id="2104935at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="263" mass="29551" checksum="6332DEC886162ABB" modified="2008-01-15" version="1">MPPLQGREKGLNDELTWAMMIQDAWGFVHQLLGLDEKHVLFDVGDRVKTGDVIGLAPSTPLSAMPPSKRPPLDVPVHYQEEGYEPYPFRFRKLEIRVARPHRHWTRYMSPDADGWSYFNPLLMYVRGRAPPVMIPPFMDVSTLVFAPSTSVEVPHAFPAYSGKRAIPIPSSKVDVFVRMQTFVESPGDAADAMDPVTPYAMDWAVQPVVKGAPKTLCAAKDVYWRRSFEHSKLELDDTSLDDASFMIPRRARCMGCGSSEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWJ9</accession>
    <name>A8PWJ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731858.1">
        <property type="nucleotide sequence ID" value="XM_001731806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWJ9"/>
    <dbReference type="FunCoup" id="A8PWJ9">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWJ9"/>
    <dbReference type="GeneID" id="5856163"/>
    <dbReference type="KEGG" id="mgl:MGL_1126"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1126"/>
    <dbReference type="InParanoid" id="A8PWJ9"/>
    <dbReference type="OMA" id="DVNRNAC"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000077">
        <property type="entry name" value="HemK methyltransferase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21733" checksum="93AC801C48B9E0F2" modified="2008-01-15" version="1">MIPTPEVAHLRRAEYTNEVYDPAEDTFALMDALENDAEALQALNASLCVEIGSGSGCVSAFVSKMLGSSADELTRKTLLHPVVASVLDGLRPRIDGAVDLLLFNPPYVVTTEEEEANEQARASLGGAWAGGTNGTKILDTLIHDDRVLRRGGRFYVVAIRQNDPHALVRAMQSKGLDASIILHRRANREQIFILRAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWK1</accession>
    <name>A8PWK1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dephospho-CoA kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731860.1">
        <property type="nucleotide sequence ID" value="XM_001731808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWK1"/>
    <dbReference type="FunCoup" id="A8PWK1">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWK1"/>
    <dbReference type="GeneID" id="5856165"/>
    <dbReference type="KEGG" id="mgl:MGL_1128"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1128"/>
    <dbReference type="InParanoid" id="A8PWK1"/>
    <dbReference type="OMA" id="IRMRIVV"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16059" checksum="7BD8EC08E7BD332E" modified="2008-01-15" version="1">MIIVGLSGGIASGKSTVSRILRENRIPLVDLDEIASLVVQKDSPTLKRLAADFGPSILNEDGSLNRGELGRLAFSSKERTRALNRITHSAIRRVLIWRLIRLWLSGAKRVVVDTPLLIEVGLYKWCAEVVIVWWYVTPICVHAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWM3</accession>
    <name>A8PWM3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731882.1">
        <property type="nucleotide sequence ID" value="XM_001731830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWM3"/>
    <dbReference type="FunCoup" id="A8PWM3">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWM3"/>
    <dbReference type="GeneID" id="5856187"/>
    <dbReference type="KEGG" id="mgl:MGL_1150"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1150"/>
    <dbReference type="InParanoid" id="A8PWM3"/>
    <dbReference type="OMA" id="CLNAREV"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="12">
        <location>
            <begin position="139"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="631" mass="70457" checksum="D8E3104F17C6EDB9" modified="2008-01-15" version="1">MASHFELRAKPEPSVDAESAAGFDMPAAYSAGVTAETCEEIFVEGRDRLCASIDATNAVLRDLRTFNKDQWILRYPSKEVSTDSSTWPLSILRLDLKLGATQNASALVSSLEKSSVGQLLDERMSRSLKHLQSLRMRIIDTQSKVLVTGDLNAGKSTFINALMRRDLVPTDQQPCTSVFCEIHDAERENNGREEVHLVRDVSSYDAENSSTYTRRSLDELEAIFAEEEDKEDESEPPVLKCFCLNAREVHESLLHNGAVDIALIDAPGLNQDSVKTTALFAREEEIDVIVFVVSAENHFTLSACEFLLNASNEKAYVFVVVNKFDQIRNKEKCRRRVLEQIRQLSPRTYEEAEELVHFVDARAMCETTNDAASSNDQAERFAALESNLHQFLLRRRTKSKLLPAKTYMERLLNDMLFLVQLNESAAKEDLAAARRELSVSRPALAACESNALKAQRIVENEEDKVVSSITQSTEEAISNALETVGQGQSAHASVKLPAYPGLLSLWQYAQDTREALLKSLQAAVNECESKARDFTADAVNRVTHTGEQFLPKDMELPKRVFVPEAMFTKRHENTAFAGLGVSLDIVSVRLTDLFDVPYHFSLVMGGERAKVSSESEEKLSQRQALLLASVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWZ7</accession>
    <name>A8PWZ7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1273</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732005.1">
        <property type="nucleotide sequence ID" value="XM_001731953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWZ7"/>
    <dbReference type="FunCoup" id="A8PWZ7">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWZ7"/>
    <dbReference type="GeneID" id="5856310"/>
    <dbReference type="KEGG" id="mgl:MGL_1273"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1273"/>
    <dbReference type="InParanoid" id="A8PWZ7"/>
    <dbReference type="OMA" id="EIRYRRI"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="276" mass="30610" checksum="7182335FAB54DF09" modified="2008-01-15" version="1">MLARMSRRWIFPIIPQTRAASSYAQRPAASASSFADRMASATRTRAPAPSSSSSSATNSTSTAHSSAAIKKTEEESEINNKSSLDVRTPLGEAFPAVSEWHSGYQGIGLRPFPAQVAHVLCEPVDKNDVEIKPDGLLYLPEIKYRRILNRAFGPGGWGLAPQGEPEVSQGILSREWTLICLGRFVSTARGEQEFFKPTGIPTANEGAKSNALMRCCKDLGIASELWDPRFIRQFKAKHCVEVWCQTSDGKKKRYWRRKDDEPFQYPAKETGLVSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX56</accession>
    <name>A8PX56_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731149.1">
        <property type="nucleotide sequence ID" value="XM_001731097.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX56"/>
    <dbReference type="GeneID" id="5855456"/>
    <dbReference type="KEGG" id="mgl:MGL_1332"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1332"/>
    <dbReference type="InParanoid" id="A8PX56"/>
    <dbReference type="OMA" id="GAPERAY"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="690"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="820"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="906"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1154"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1203"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1239"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1310"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1367"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1701" mass="178290" checksum="31BF43F2ADD2C0FF" modified="2008-01-15" version="1">MGSRAPVHAEMSMSPTSPSQLSSVSKELPHTFQRSGLSSNGPAQQALTRVGSSQSPPAIKPVLSPTQAPSSNSLLPTTTPGSLSTLVRPNDGASGPNGQESFSNARPVLQPTSPTSVGPSVRPSLHQPLLPASSSSASAAHSTMISPLSQASPSNGKAPEGKTLTHTDLAPLNLKDLDDKSVSGTPNGSSLSPTPLPFLERLSTIQPQIPNPLANKDTETRKVPNGTFQSEGSSVDESQPLVNSPTGDDDRLLDHRHLQPGETVSLLSHKKTLDMYRENAKKTNDPQLNYELAIFMLDVSRSLEFSEQILSRGQDPAAEREHLAKEAVNLLRRLADRGHVESQYLVGDCFMNGYGLSKGRPDLGLAYSYFTQAGKRGHPDAAYRAGTCYEKGWGCRRDQAKAVQFYKMASSRKHPGAQYRLGTAELNGELGLKRSAREGVKWLKRSAENATPEFPHALHELALLHEKGIYNVLFVDYEYSCELLAQAVEMGYAPSAYKLGVNYEYGRMGCPQDSGLSIHMYNIAAQQNHKEACFALTAWYLVGAPGILPQSDTEAYLWAKRAAEQGLAKAEYACGYFSENGIGTARDLSEAKGWYQRAVEHGDSRASSRLNTLSGYTAKQVGSAPDESATRNQPKAIPVQPLSAPFPSAAPMSTMRTLGVLNYPTPKAMRETQAVQRDLHQQALVAAIEERDRSRSDLSSPQGGSFFGPGWQAGRLPNKPFSPSQPPKEGGKPMNLIAAGPRAGFPKPPTPPPPEPEPEPEPEPDAAQAGGKHRLKARVFRFGRKNKSDKGAELPEQAEGEVPASSSAPNVGIAADGPLSPTTTQEATLVQSDGSNPVSPTSPPPPGQLAITSKPEGELDNGNKPNGPSQALSLLPRPPGQRPGAPLQPETKPQETSQQGQAQSKKPNETEPKDVEPFIGEKPKEESSSKPGFSLFGLGKKNKNKGSEKSSAREDDSKANKESRLPPSDSSAVASPGLKGQQVGSDTTTSPKLEPQDASKTSAQQKSVNPSQSPQGLQPSGSTATWTQSNSSGPPVLAGFAPGRPPLRPQQGMPGHAKPGSPLEGPRQAMPGSLVPGHPSSEHKPVGPTPISPAHPPDQLGGPQHGTSHGNFSGPLPAAHQQGANAHSTSGPSLNGPQQSAGSIVALRPPNVPPSSSHAPNHTPSTRSLAETQPVVPVNATPVRPSSGPVVRGSYESTDDSRSVGNLQPNPIGSTGHPRPASNGRPGVPAGLVPARPSIGTSSGMQGTHNAGRLTSMNSRSSMPNPTMSGQPTASSTPTDVSHEQARMSMPNNMLQLRPVSPSRPPAALQPSTQTPQRPGNPSVLTASGQPHVLRSPGPQSPSSPTPTHQEPGHRPLIRPQQARPSPGSPPPSMMPGRPPVGPGGPVSPQAGPRQQQPLSQNQGVMPTRPNFPPHPNMAGLNGQSSPRGTPQPHLHPGRIPPSSSHSYVRPPSAMPPPSMQPGSASPPGRMPAQLHSGRPMNVQSRGLGENQPISMQALMPGQSYSGGNPSIPPGMSSQQAGRPSAQMGRPPTAIMPPNQLPGRPIPPNSAPGMNPSFPNHPGTLNPTRPSMPSAVAPGMQSGHMVPGQVRPGVPGLPQSGGPPASHNARPWAMSSPVRPVENNTIRPSGPGSPPHGTGAARSMLGSPNSVGTDIDKFEDAPSAEIAQGPPGAGGGMSSPIKPDPNMAGDKNARRKFLGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXB0</accession>
    <name>A8PXB0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731203.1">
        <property type="nucleotide sequence ID" value="XM_001731151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXB0"/>
    <dbReference type="STRING" id="425265.A8PXB0"/>
    <dbReference type="GeneID" id="5855510"/>
    <dbReference type="KEGG" id="mgl:MGL_1386"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1386"/>
    <dbReference type="InParanoid" id="A8PXB0"/>
    <dbReference type="OMA" id="DNLWTEP"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000007">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF46">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="323" mass="34979" checksum="F3F12C5DECB1CE32" modified="2008-01-15" version="1">MELLIILSACKTASARRITAVIPSFPYSRQNKKDKSRVPITAKMIANMITVAGAEHVITVDLHASQIQGFFDIPVDNLTCEPSIARWIRHKVDDWRDAIIVSPDAGGAKRATSLADSLGIDFALINCSRHLQKNHRQRSNTNESADMALMAHSHSSSEVANGVHSLSESGEWFITSEGGGRVRSGGARKQVSAAEESADEVDSIMELLVGNVTGKTAILVDDMIDTGRTLALASKTLEAAGAKRVFAIVTHGLLSGRAMDLITRMQIVKLVVTNTISNTEKALQSNGKVEVIDMSAVIGETIRRSHHGESISTMFRQDAEMMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXE1</accession>
    <name>A8PXE1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731234.1">
        <property type="nucleotide sequence ID" value="XM_001731182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXE1"/>
    <dbReference type="STRING" id="425265.A8PXE1"/>
    <dbReference type="GeneID" id="5855541"/>
    <dbReference type="KEGG" id="mgl:MGL_1417"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1417"/>
    <dbReference type="InParanoid" id="A8PXE1"/>
    <dbReference type="OMA" id="QRCPPAV"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="400" mass="45896" checksum="BB91C5FF1C2E45AF" modified="2008-01-15" version="1">MGLHLQVCRWPLRLPQQYRAPLPMVIWHGLGDSAYSEWLIKLKEDLEDMYPGIYVHLISLDSTPSGDKSATFMGNVNDQIEQVQRQLAKVPELQAGFDAIGFSQGGQFLRGYVERFNTPRVRNLVTFGAQHMGITQLPGCAEGDRLCNLVMRSFEGRMYSDFAQTRLVVAQYFRDTRLASQYQQYEQRNRFLYDINNEGPSKQELYKTNIKQLEKFVMVRFSEEETVVPSESAWFSAYEDPEHRRDDAVNMTIPLRTSRLYKEDWIGLRHLDARGGLAFHTCEGQHMQLSPPCKSLVFHTYVGHPRFDEASMNILEGFMNISLYALICIGLMICMRRLYRPLGDATHVTAPSSLGALEPRAKHEAAFPNLVGTQRFRREPIYGNANTPHDMRQVSFVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXH3</accession>
    <name>A8PXH3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731264.1">
        <property type="nucleotide sequence ID" value="XM_001731212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXH3"/>
    <dbReference type="STRING" id="425265.A8PXH3"/>
    <dbReference type="GeneID" id="5855571"/>
    <dbReference type="KEGG" id="mgl:MGL_1447"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1447"/>
    <dbReference type="InParanoid" id="A8PXH3"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="169" mass="18443" checksum="0679924F3B7611D7" modified="2008-01-15" version="1">MLSAERRSSDDQNARWYAPHDDHILLQRIRAQGKPSAADIDFDQLVTPDWQWPMYVIKKHWIVMLRKRVPPDFHGSFAELLDLLSRHVPSPEEYKMLASGRRPASNSNSTANALANVRKDVQSPASTLDDASGTVPHLVASTPSAPLGPSGQAPTPPPPAPPPAPPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXJ6</accession>
    <name>A8PXJ6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731279.1">
        <property type="nucleotide sequence ID" value="XM_001731227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXJ6"/>
    <dbReference type="STRING" id="425265.A8PXJ6"/>
    <dbReference type="GeneID" id="5855586"/>
    <dbReference type="KEGG" id="mgl:MGL_1462"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1462"/>
    <dbReference type="InParanoid" id="A8PXJ6"/>
    <dbReference type="OMA" id="CAMSIPF"/>
    <dbReference type="OrthoDB" id="5554402at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019419">
        <property type="entry name" value="AIM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28177">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28177:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10315">
        <property type="entry name" value="Aim19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="163" mass="17879" checksum="8E507DA98D205729" modified="2008-01-15" version="1">MPDSMTTPMLKHINPFLADMRKHASDSRPAYAMSALCAMSMPFGFGYAIKTAGNEAAKKAPRLIPPFWQLLGFSVFFGTGAYMIDHGDVLNGSGVISAWSLTYVTFHTLRTARWLLRSPLALLLSSTVTGIGLGVYANYYFDKSSWRGAVPGLLPKPRESRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXL0</accession>
    <name>A8PXL0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXL0"/>
    <dbReference type="KEGG" id="mgl:MGL_1472"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1472"/>
    <dbReference type="InParanoid" id="A8PXL0"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="17" mass="1949" checksum="7F399341E78CAFDE" modified="2008-01-15" version="1">MPSITFSLPNNVFGFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXV9</accession>
    <name>A8PXV9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1536</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731353.1">
        <property type="nucleotide sequence ID" value="XM_001731301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXV9"/>
    <dbReference type="FunCoup" id="A8PXV9">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXV9"/>
    <dbReference type="GeneID" id="5855660"/>
    <dbReference type="KEGG" id="mgl:MGL_1536"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1536"/>
    <dbReference type="InParanoid" id="A8PXV9"/>
    <dbReference type="OMA" id="RANSPHI"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000341">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="207"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="525" mass="57079" checksum="24721F6B9A280BB4" modified="2008-01-15" version="1">MNNEQPASNQESQREQIKPSLPTINFPEAEHPRVSVPKGVAGGFAGINARTREKAAAKLPPSLRAKLEENARLSSLGSPTGTSGSATVMGHAEKIDPSLLMPKGPVPRPVMPPARPRPNLRLSDMGALQARAGAEGAKNLNRAGPSNRPNLSLGMLPEAAKPDTPFGSFSKIVDPSGRLVFDGKAVLHASGVEFKNGTTFNINMDELELLEQLGHGNYGTVTRVRHTRTGVEMAMKEIRLELDEAKLNAIIMELDILHRAIAPQIVEFYGAFFVESCVYYCMEFMDIGSLEKLTTGRHCVVPEDVLAHITLNTVKGLSFLKDELQIIHRDVKPTNILINSRGEVKLCDFGVSGQLEKSLAKTNIGCQSYMAPERIKGDPRSMMNTYTVASDIWSLGVSLVEITMGTYPYPPETFTNVFAQLQAIVEGAPPRLPTPSSEPITVTMPNGTTVDLELGTCEYSARACDFVAQCLCKIPEQRPTYAQLLEHPFLTHVPDVDMAAWAAHAHATRRVPAKDEHAAPPVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXZ4</accession>
    <name>A8PXZ4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1558</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731375.1">
        <property type="nucleotide sequence ID" value="XM_001731323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXZ4"/>
    <dbReference type="STRING" id="425265.A8PXZ4"/>
    <dbReference type="MEROPS" id="C54.001"/>
    <dbReference type="GeneID" id="5855682"/>
    <dbReference type="KEGG" id="mgl:MGL_1558"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1558"/>
    <dbReference type="InParanoid" id="A8PXZ4"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="159"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="187"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="606"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP44161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="651" mass="71863" checksum="2433B831F42DB9DE" modified="2008-01-15" version="1">MHASEPTAARNVSAYSPQQHHTHDGSSPTKPRGSDEEPSPYSMFRRHSATQIQRSRHRPRRNRVMRPMSLAPLSEWSLLDRVSNRIRGQVPAALWQMTCDRLWRLWPSSDPQVWLMGEFYGTPEPSSSVSRSSASDASSSMSEHTSHSTGREVQADLDCSIASLVWCTYRSNFAPIPSEDTASAASEVLSTSSYSPDTPSTATAVDSSHQSDPSAKETPLCPSQMHSSQQPISDHQPVSTLLSLVEAVLGSSDTLPTSVTWLAHQLKARGWELLASHGVPYTSPTAHTAFPGVWHSVHAVFQHILSLTHRTCFTSDVGWGCMLRSVQSMLANALIRVHLGRHWRRRAKQKTHPQYARILSWFMDDPSLECPFSIHRLVDEGQRLGVQAGDWFGPSTAAFALCKLIQAYDACGLGVVVTNDGMLYKEQVVAASFAPGRSDPWTRPVLILLVQRLGLDQVPPHYRPALKQSFTMPQSVGVVGGRPRSSLYFVGVQREHLLCLDPHHVRPCVPFRSPPRMTRASVGASTDLASTVSPWFEEAYTAEELDSFHTPHTSLLPISQMDPSMLLGFVCEQASDLIDLQARIESSETRLFDVADNMPSYYRLSMSMGGEGEGDDDDNHRTHKAEDGHSDRVAAHSGVGDNVDDSGWTMA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYF7</accession>
    <name>CBP4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName>Assembly factor CBP4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cytochrome b mRNA processing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CBP4</name>
        <name type="ORF">MGL_1653</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CBP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731470.1">
        <property type="nucleotide sequence ID" value="XM_001731418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYF7"/>
    <dbReference type="SMR" id="A8PYF7"/>
    <dbReference type="STRING" id="425265.A8PYF7"/>
    <dbReference type="GeneID" id="5855777"/>
    <dbReference type="KEGG" id="mgl:MGL_1653"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1653"/>
    <dbReference type="InParanoid" id="A8PYF7"/>
    <dbReference type="OMA" id="AKARWIQ"/>
    <dbReference type="OrthoDB" id="5576752at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000341598" description="Assembly factor CBP4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="73" mass="7949" checksum="C8032C1289DA4E00" modified="2008-01-15" version="1">MAGGPANWARAITGGSVVIGFGYLLLKTATPNEQQLYDSLSPDLKRRVDAQRSSQADSERSAKVKEEQSKRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYH8</accession>
    <name>A8PYH8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endomembrane system</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731482.1">
        <property type="nucleotide sequence ID" value="XM_001731430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYH8"/>
    <dbReference type="STRING" id="425265.A8PYH8"/>
    <dbReference type="GeneID" id="5855789"/>
    <dbReference type="KEGG" id="mgl:MGL_1665"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1665"/>
    <dbReference type="InParanoid" id="A8PYH8"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="84" mass="9255" checksum="61872E8FC1D457A8" modified="2008-01-15" version="1">MSDRPDTQRTVSKEEGQAFAEKHNLLFFETSAKTGQNISEVFTTVARDIFERYKSNPSSARRSINPTDSVDIASTTSSAASCCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYJ3</accession>
    <name>A8PYJ3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1673</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731490.1">
        <property type="nucleotide sequence ID" value="XM_001731438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYJ3"/>
    <dbReference type="FunCoup" id="A8PYJ3">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYJ3"/>
    <dbReference type="GeneID" id="5855797"/>
    <dbReference type="KEGG" id="mgl:MGL_1673"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1673"/>
    <dbReference type="InParanoid" id="A8PYJ3"/>
    <dbReference type="OMA" id="MVDNIQD"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="221" mass="23851" checksum="3E5DE89DCEE94961" modified="2008-01-15" version="1">MMASRFVPRVLNQTRGYASQAAIRPPIQIEGLAGKYATAAYVSALTKSEKDLSKVESDLKYFHDVLKSDSPDAVKLRSFLTNPTVPAQTRTSTISELLSKQKGGADELTTNLFNTLSQNGRLGLSEKVIEGFLQLTSAHRGEVIITITSAKPLEKSISSRLESALKTSQFATTGGAKSVKFDYKVNSSLQGGVTVDLGDRSVDLSVANRVNKLNALLRDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYM2</accession>
    <name>A8PYM2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731505.1">
        <property type="nucleotide sequence ID" value="XM_001731453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYM2"/>
    <dbReference type="STRING" id="425265.A8PYM2"/>
    <dbReference type="GeneID" id="5855812"/>
    <dbReference type="KEGG" id="mgl:MGL_1688"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1688"/>
    <dbReference type="InParanoid" id="A8PYM2"/>
    <dbReference type="OMA" id="DASCMWR"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="560"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="661" mass="74685" checksum="E3093D8371B6D51D" modified="2008-01-15" version="1">MLFARKELNFERMSERDRKHIVSEVNILRTLQHENVVRYEERYVDTENGILYIVMELCEGGDLGSVIKRCRRTKTHLPEETVWAYFAQMTAALEACHYRKVPSSATNVGARAVQAILHRDLKPENVFLDADQNVKLGDFGLSKQMAAQSFANTYVGTPYYMSPELATGQPYDMKSDVWALGCIVYELCALSPPFDAENQTELTRKIKQGTVPALPRTYSRDLQDAVHAMLQLDHRRRPTTRQLLQIRQIKMACRTHDIAVLHKKVLLEKERLQVQKLALDEREASLSEREQKLLQDEGAWHRSSAGSSTLSKALEDRALALNQRELELCRREEACASHHQTALEEWEHQRALMQEKIKLLQQQLDETKTALSQASMSDAASSYTRPRPRKSTVMSTPKGEEFLRSRIAEGALSLQSPPRAGRQCHVADDEWVDDEDEPLHRAATATATGTTTRAPPLIGRSRRAEADLSDCSMKDASCMWREALPFRGRAEATPAKAKRTSLPETVLEGSDAPSLPTSRTMPMNLNNLPQEPQWHLMEEDERPSPFLKRVNRIPLENLRSDGLADDTNAGMRLVPGPAKPRSGPIRTQDAHADQENLSSPRARVLADHRRRRSSLLRPSEARPIYSNNTSRVEALRSRPSGIPHSPSARSLRPFSAAQRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZC2</accession>
    <name>A8PZC2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_1907</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730908.1">
        <property type="nucleotide sequence ID" value="XM_001730856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZC2"/>
    <dbReference type="FunCoup" id="A8PZC2">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZC2"/>
    <dbReference type="GeneID" id="5855215"/>
    <dbReference type="KEGG" id="mgl:MGL_1907"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1907"/>
    <dbReference type="InParanoid" id="A8PZC2"/>
    <dbReference type="OMA" id="PISHYPQ"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="19"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="307"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP43694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="398" mass="46255" checksum="FD4109EF6AEB7407" modified="2008-01-15" version="1">MARVFPTTQLPYQEHHPLKILRDEIERVFGKKYTPIRAPSPVVTSKLNFDDLGFPADHPGRMPSDTYYVNRETCLRTHTSAHEVETFRAGYKRWLLTADVFRRDEIDSSHYPVFHQMEGASVWSYDAFNRGGPVEQECIAMETILQQAGMEIHDDVNIDEADGWQDVHMRDHPDATKLALRHLKASLNTLVLALFRKRWAEEAQTNEPLRVRWIPATFPFTAPSFEVEVWFRGKWLEILGTGIVKQRTLDVAGIPKNLGWAFGLGLERIAMVLFSIPDIRLFWSEDARFLNQFKSAEPLNITFKPYSKYPPCYKDVSFWMPQSFHENDMFETVRDRAGDLVEDVVCIDDFLHPKTGRHSRCYRINYRSMDRNLENDQVNALHAEVVNALVSRCHVQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZT2</accession>
    <name>A8PZT2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730948.1">
        <property type="nucleotide sequence ID" value="XM_001730896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZT2"/>
    <dbReference type="FunCoup" id="A8PZT2">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZT2"/>
    <dbReference type="GeneID" id="5855255"/>
    <dbReference type="KEGG" id="mgl:MGL_1947"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1947"/>
    <dbReference type="InParanoid" id="A8PZT2"/>
    <dbReference type="OMA" id="TNDLREH"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11815" checksum="0244C626B2747682" modified="2008-01-15" version="1">MALRIQQRRNELQTIVEKIGEIESDADEHRLVIKTLKEVHEREPDRTCFRLVGGVLVERTVKDVLGTLQTTMDGLNKVLVELAKQYKARESELLEMQRELDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q072</accession>
    <name>A8Q072_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase-like protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730992.1">
        <property type="nucleotide sequence ID" value="XM_001730940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q072"/>
    <dbReference type="STRING" id="425265.A8Q072"/>
    <dbReference type="GeneID" id="5855299"/>
    <dbReference type="KEGG" id="mgl:MGL_1991"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1991"/>
    <dbReference type="InParanoid" id="A8Q072"/>
    <dbReference type="OMA" id="CIINDAC"/>
    <dbReference type="OrthoDB" id="61116at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36149" checksum="F275A69CFDEB0655" modified="2008-01-15" version="1">MADLHIVAPRAQTASDTLHKCVAEATQHAASCIINDACHSSADPTACPRRVPFFLLQLSTSTTLHGTQVAYTLCVNEHETPQRIHWIWRGRQSTFTLPPRSGFLLMDLLREERQLPRAWHTLTERLDTMGGADLVLLDPPWPNQSAQRAWRGQSRFKYRTMLDLYDMWRLRPAMESLIRPHTLVAVWVTNHPKVQTFVRSKWFPGLGLTHHATWAWLKLTAPEEGASPDMLVPWGDLSFRRPYELLLIGSRDDSCTVPKHHLIMSAPLGHSCKPYVSNMLCPEGSAVVELFARHVSCDARWHISVGDEAVRGNEEWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0F2</accession>
    <name>A8Q0F2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731025.1">
        <property type="nucleotide sequence ID" value="XM_001730973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0F2"/>
    <dbReference type="FunCoup" id="A8Q0F2">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0F2"/>
    <dbReference type="GeneID" id="5855332"/>
    <dbReference type="KEGG" id="mgl:MGL_2024"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2024"/>
    <dbReference type="InParanoid" id="A8Q0F2"/>
    <dbReference type="OMA" id="TYNDVHN"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28619" checksum="240C07A931C406FD" modified="2008-01-15" version="1">MSSDSLPRTMASLPDDHWRPTYEDIHIMIRDISVKIREEFQPDLIVAIGGGGFFPARVLRTFLKKRDAQNPNKMRNLPIQAIGLSLYEEVEGVSGEMIGKEVIRTQWLDKGDVVGNSTTQNDAGGLLGKNVLIVDEVDDSRTTLHYAYHELLKDVRKAIQSYTPEERAKIPPTRFAIFVVHNKLGPKRAELPMIKEPKDEVIEDGVSTGVYYYAAEMMPPVWINFPWEETDILEHNRLSELAKHLGVGQPPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0R8</accession>
    <name>A8Q0R8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2072</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731073.1">
        <property type="nucleotide sequence ID" value="XM_001731021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0R8"/>
    <dbReference type="FunCoup" id="A8Q0R8">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0R8"/>
    <dbReference type="GeneID" id="5855380"/>
    <dbReference type="KEGG" id="mgl:MGL_2072"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2072"/>
    <dbReference type="InParanoid" id="A8Q0R8"/>
    <dbReference type="OMA" id="AICAMRI"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="756"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="678"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="737"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="865" mass="94817" checksum="FF4F125D67772371" modified="2008-01-15" version="1">MSSFFQTQQQVAALDPRLGSLMASAGLYNLRALIKGVRACKTLADERALLQKESAAIRTSFKDDDAYMRYNNLSKLLYIHMLGYPAHFGQMECLKLVASPRFADKRLGYLGIMVLLDENAQVLMLVTNGLKNDMNHSNMYIVGLALCTFANIASEEMSRDLCNEIEKLMSSANSYIRKKAVLCAKRIIRKVPDLVDHFRHRTLQLLSDKSHGVLLCTISLAIQICETDPSSVALFRRATSSLVAMLRNLLSTSFSPEHDVAGVTDPFLQAKILRFMRVLGRDSAEVSDMINDILAQVATNTDGSKIVGNSILYECVLTILDIKADSGLRVMAINILGKFLGNHDNNIRYVALNTLIKVVSIDTNAVQRHRATILACLRDVDISIRRRALELAYTLINENTVLSVMHELLQFLEVADTEFKLGLTTRIGMAAERFAPNVRWHVDTMLHVLRVAGQYVREEVLASFLRLVCHTPELHAYAVEQLYVALHSDMSQLYQTLAAVWVIGEYGDLLFERGSVEIDGSVYKLDPKSVIDVLAMLLDSVYATEPVREYTLTALPKLYTRMQDVTQQKRIQSILAQYDESIDLETQKRALEYGALLKRASIRDAVMEVMPLPLQRPLTTGSASEAQSSLGAAAAASSAATSDSLLLDTDAGASSTGGASTTPAPKQNAHDLLADIFGSGNESASENTSSASSTASTVTKKPSSAQQDILGLFDSPAASEHTTASDVAQTTSAFGEMDLLGSSGDDTSSMSKAPTPLPEDPPVYSKNGLNLALVVTRQEGKDVLVQARFLCTSGAVESIMLQAAVPKTQHLQMHALSKSTLYAGEQAMQDMDIAGVMSGKVRLRIRLIYRVRGEEVRDQLDWTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q169</accession>
    <name>A8Q169_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1743</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730744.1">
        <property type="nucleotide sequence ID" value="XM_001730692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q169"/>
    <dbReference type="FunCoup" id="A8Q169">
        <property type="interactions" value="652"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q169"/>
    <dbReference type="GeneID" id="5855051"/>
    <dbReference type="KEGG" id="mgl:MGL_1743"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1743"/>
    <dbReference type="InParanoid" id="A8Q169"/>
    <dbReference type="OMA" id="QVVTKIF"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="420"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="155"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="525"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="597" mass="67269" checksum="F55278EC85F7FCEF" modified="2008-01-15" version="1">MATTQFDNVYHGNGKALGMIRFSQAGLGWKPLDEGSTVTIPADQMTAFAWLRVARNFQLKIKMKGDGEGEHVATFENFQREDHARLEQVLRECYDKALETIEISTRGWNWGSAEVGEHDMLFYVKNRLAFSLPLANIANSNIAGRTEVSMEFINPKDQRPEQNTGASSGADGLQFHGSKKNRPDQLVEMRLYIPGQAGREEDDEDENDNGQDSDIKKEPSAGGGESKQATKREDGDERADDEEEEEEEEEEEEEEEESAALAFHNAIKAKADIGQVAGDGILVLKEVLILTPRGRYDIDLFPTFLRLRGKTYDYKILYSSITQLFLLPKPDDIHVLFIVALDPPVRQGQTRYPFLVLQFPREEEMDAELNLDEETIQTKYEGKLKKRYEEPTFRIVTNLFRVFSQQKVHVPTGFTNSTGQESVRCNVKANDGMLYPLNKSLIWVSKQPILISYHDVHQFVFSRVGGAIASAKTFDLRVELQHGTDHTFQSISREELDSLNNFFAERKLRVKNELTDEAMGVGAAVDELLGEDDENVTSGKRGRGDDEDDDDEEEDEDFEAESEDDGGSPSEASSDDEDGDAVVSEEDEKPKPKKPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1B7</accession>
    <name>A8Q1B7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1763</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730764.1">
        <property type="nucleotide sequence ID" value="XM_001730712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1B7"/>
    <dbReference type="FunCoup" id="A8Q1B7">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1B7"/>
    <dbReference type="GeneID" id="5855071"/>
    <dbReference type="KEGG" id="mgl:MGL_1763"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1763"/>
    <dbReference type="InParanoid" id="A8Q1B7"/>
    <dbReference type="OMA" id="MELPDIM"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="13">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="14">
        <location>
            <begin position="80"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="225" mass="26307" checksum="4C8EE7E3F2D62235" modified="2008-01-15" version="1">MQEFKGHITLAFGESDEYRYMSFLIDKNSTLYNRRQSKLVTHIVSLFTSAYVFYWNTYMSTPLKEAPSFDGRLVVYPGEQEVRDYFSWRQADTHINNLYNTVFWALVLEGKKTEREAHNILKGTVSADKHEILFKEFGINYDKLPAFFRKGTTLVWAPVRDPNRTKPRTRLFTLHVDIIGDDFWRTSGESLAPVEARCEGESVDHFYEQAERHYGTGFGSNVLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1C3</accession>
    <name>A8Q1C3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730767.1">
        <property type="nucleotide sequence ID" value="XM_001730715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1C3"/>
    <dbReference type="FunCoup" id="A8Q1C3">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1C3"/>
    <dbReference type="GeneID" id="5855074"/>
    <dbReference type="KEGG" id="mgl:MGL_1766"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1766"/>
    <dbReference type="InParanoid" id="A8Q1C3"/>
    <dbReference type="OMA" id="FVANVQD"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="1">
        <location>
            <begin position="215"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1010" mass="114178" checksum="C770566D0CC71B2F" modified="2008-01-15" version="1">MEDNELFQSVLRSDGIEEASENWIVAYQGEPHESLAQLVTFLFRLCGCTATITSDEVQDSEHVDDVLERIQDEFAQHLHSQYPIVSRSKSLKNIRKHAALLIKKIFSDASEAELLSDEDFLDTWQQWLLAMSVSSLRSFRHTSSLVAMWTIGAFSHELEQVRENYDVAVRQRDAEAKRQSANRTRLVHTAHKMEQLDSLRESLDAHLDDYVKHVFSPRSRDFDALVRLDCVDQLGSWMKEFPTQYLQEYYLRHVGAALSDPDVTVRLHALRSIKNVLVPEHAIQLVSFSEAHKSRMVDMALYDVDLGVRTTAFAVLESANELDMLSNDDRAALAVHIFDLESRIRAAAAAFLNGLLQNHVAAKMQDNTSDESIVRVHCLVKLLSHYTQQLNAGTDDLDSDKLSLIEPGLGRVSVAFEALWDTTDSLHAWKPYIDILIPDEGDYELVADEEAVAVEILAMCVHLVKERTDPDSDETAWEECSVYLIHALPKLLAKFSADTPRISDLLFIIPSMKLDVYHETRNMDAFESLWEDLCGHFMRHVEPVLLQRAAEAIKLLALAPMDTNTSNNRLLSLKETVLSLLQDTLHQRQLDTTVFSEDDVHNIQASLARLHALLKKMDVSTLLDDDLIWNQIKALSLRGRLNYPQECQFVALALETLSLYLMWRTKDALLNETKQMDRDDTLLSRRNAVLDVIHSFLDRTSRVQSSALHVALLLYTLFFSIPGKDNSKHYLYMTCPSHIQERCAALFATELHTLVSSYHEHNKSRPRKGTFMPLDSTLLASDLHLFTLAGVYAAAIRVGALNVSYAAPMLSYYAYFSLDFDALCHELVAVMKDDALHSNRGWIVCETILETLKGSFSLFLLFNDDASEAHYISLSRQLANATMIRGPGFSVIQSVDPKAITTLHVAGVQQFISYFHEGTGNKGREPVFFKGMANLLATLLPADAMKIHTTMQQRFLATNIKPEQGAREWEPYFSYEKRLLNLAAKDADIVKEASHYANDSSTQLPTANST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q208</accession>
    <name>A8Q208_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730869.1">
        <property type="nucleotide sequence ID" value="XM_001730817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q208"/>
    <dbReference type="FunCoup" id="A8Q208">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q208"/>
    <dbReference type="GeneID" id="5855176"/>
    <dbReference type="KEGG" id="mgl:MGL_1868"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1868"/>
    <dbReference type="InParanoid" id="A8Q208"/>
    <dbReference type="OMA" id="NAREREX"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="6">
        <location>
            <begin position="101"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20638" checksum="49B9905D92E4F143" modified="2008-01-15" version="1">MATLFSLITCLDYLERAYVRGAVHEEAYATQCSRLLGQYKTVIKLITDPSQPPAYRFHDVHAFMQHFHMDHPAAAHRLALGIPATIEHGGNETTGPASQGVGAQIVAETTQNFITLMDALKLQMRAKDQLHPLLSDVLSAYTKAGTNSGESREKLLEWCVGTCSCSMCDDRLTHHIQAHSVKSTQCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q250</accession>
    <name>A8Q250_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2135</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730681.1">
        <property type="nucleotide sequence ID" value="XM_001730629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q250"/>
    <dbReference type="FunCoup" id="A8Q250">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q250"/>
    <dbReference type="GeneID" id="5854997"/>
    <dbReference type="KEGG" id="mgl:MGL_2135"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2135"/>
    <dbReference type="InParanoid" id="A8Q250"/>
    <dbReference type="OMA" id="ITYCKTR"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="193"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="596" mass="65574" checksum="61020BB14FFCE6F1" modified="2008-01-15" version="1">MRDLHADNISRLVRIPGIVISTSVPSSRVTRLHLMCRDCRAVKTLNVSSGFGGFVLPRQCDAPKVDPSLRCSVDPFVILHERCSFVDAQTLKLQEAPDMVPVGELPRHMLLSVDRALCGKVVPGANIIATGIFSTFASSRGGSTPNAVALRTPYLRVAGLEIDTGGVGGRGTPRVFTAEEEEEFGRMAKTPDLYEKFAASIAPSIFGSTDIKKAITCLLFGGSKRVLPDGMRLRGDINVLLLGDPGTAKSQLLKFAEKVAPVAVYTSGKGSSAAGLTASVQRDANSREFYLEGGAMVLADSGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNCRTSVLAAANPVWGRYDDLKSPGENIDFQTTILSRFDMIFIVKDEHNESRDRTIAKHVLGIHMHGASEQADAEGEFDLQRMKRYIAFCRARCAPVLTAQAAEKLSSHFVAIRKQVAQMERDHDERSAIAITVRQLEAIIRMSESIAKVTLSPYATEEHVDEAIRLFRFSTLNAVESGNVEGMTRGELQEEVQKLEREIRRRIPIGWTSSHAALRKEFVDAQGYSLHALERALYILEKRDVLRFSNQRKTLTRTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q269</accession>
    <name>A8Q269_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730700.1">
        <property type="nucleotide sequence ID" value="XM_001730648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q269"/>
    <dbReference type="GeneID" id="5855006"/>
    <dbReference type="KEGG" id="mgl:MGL_2154"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2154"/>
    <dbReference type="InParanoid" id="A8Q269"/>
    <dbReference type="OMA" id="YRGHENC"/>
    <dbReference type="OrthoDB" id="2524732at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727956" description="MARVEL domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39714" checksum="FE41D6F0167163F7" modified="2008-01-15" version="1">MMSVLFTMKLEILFQFAMSAIWISGALAYAADYRGHENCQWNGYYHYPKPSNWNHLCDMINWVVGMAYATFGIQAAFLAFDLLVGAYIFMFLDQDSISEPFYEWGNRAWEYKHKPAAPLSSVHNPMLYHANPEARGARMYGPHYDEKYSYDSTLRESYSDKWSRSTLAEHPPNRRGVAYSDPSVSDRMSDESSTLASETRYYGGTYSRSSANSRRAGLAEAPRPAGSGGTSSGGAPSWKAPSVTTDSGSTRAPVSIRAKPRKPRHASAPQSLGSRGRRGTSYLSRDSDTLDDHSEVTESMINSRAYDDNDFMPAGRGVSSRRIRRHRNVDGDDADDYDTDDDDGWHLREDAYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2V5</accession>
    <name>A8Q2V5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730449.1">
        <property type="nucleotide sequence ID" value="XM_001730397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2V5"/>
    <dbReference type="STRING" id="425265.A8Q2V5"/>
    <dbReference type="GeneID" id="5854756"/>
    <dbReference type="KEGG" id="mgl:MGL_2245"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2245"/>
    <dbReference type="InParanoid" id="A8Q2V5"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="198" mass="21991" checksum="AEBCFB813EE79347" modified="2008-01-15" version="1">MLQRVALTSRASITSCISRSLAPPIRHTGVSVALIEPNELRLWRDLWRTLGRDDRVASLPIEYSFLGPIRERLALAREIDSLSHAQTKASHDDAWLRTLARDADLDYESDASDKDADVDASRRKKQKRSPSATKLASLKQRLAQLLARPLQAQGTSQKYLTSGVRPEYVQALLSGHHAPHMLGVIKSSIHADLAASKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q393</accession>
    <name>A8Q393_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730543.1">
        <property type="nucleotide sequence ID" value="XM_001730491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q393"/>
    <dbReference type="STRING" id="425265.A8Q393"/>
    <dbReference type="GeneID" id="5854850"/>
    <dbReference type="KEGG" id="mgl:MGL_2339"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2339"/>
    <dbReference type="InParanoid" id="A8Q393"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="41" mass="4522" checksum="BE6EDD1E3848361D" modified="2008-01-15" version="1">MSVDITPSRVGRPGPDPARVALFVAPITAYYYAKDNWLQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3B3</accession>
    <name>A8Q3B3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vta1/callose synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730556.1">
        <property type="nucleotide sequence ID" value="XM_001730504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3B3"/>
    <dbReference type="STRING" id="425265.A8Q3B3"/>
    <dbReference type="GeneID" id="5854863"/>
    <dbReference type="KEGG" id="mgl:MGL_2352"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2352"/>
    <dbReference type="InParanoid" id="A8Q3B3"/>
    <dbReference type="OMA" id="IISYWCK"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="107" mass="12054" checksum="7C39DDADA4E66287" modified="2008-01-15" version="1">MPRNVPTILKDAAPFLARADEVIKADPIISYWCKYYAAQIGIEKSAGDTEAQSFLMQLMDELERLKDSMSEQDAVKSETVAYAYIENFALRIFLGADNQDRQGQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3L6</accession>
    <name>A8Q3L6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730645.1">
        <property type="nucleotide sequence ID" value="XM_001730593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3L6"/>
    <dbReference type="FunCoup" id="A8Q3L6">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3L6"/>
    <dbReference type="GeneID" id="5854952"/>
    <dbReference type="KEGG" id="mgl:MGL_2441"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2441"/>
    <dbReference type="InParanoid" id="A8Q3L6"/>
    <dbReference type="OMA" id="LCEIICD"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="300" mass="33833" checksum="33C662C0B3BE4E62" modified="2008-01-15" version="1">MSSDLDRQISQLKKCESLTEAQVKDLCDRAREMLIEEGNIQHVDAPVTICGDIHGQFYDLMELFSVGGMCPDTRYLFMGDFVDRGLYSVETFLLLLALKVRYPDRIVLIRGNHESRQITQVYGFYDECSRKYGNVNVWRYCCEVFDYLSLGAIVDGRVFCVHGGLSPNILKLDQIRSIDRKQEVPQDGAMCDLLWSDPDDISGWGVSPRGAGYLFGGDVVKGFVHTNGLDFIARAHQLILEGYKQMFDATIVTVWSAPNYCYRCGNVASILELDDALNQKYKTFDAAEQGCVHERNLDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3P9</accession>
    <name>A8Q3P9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2467</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730671.1">
        <property type="nucleotide sequence ID" value="XM_001730619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3P9"/>
    <dbReference type="STRING" id="425265.A8Q3P9"/>
    <dbReference type="GeneID" id="5854978"/>
    <dbReference type="KEGG" id="mgl:MGL_2467"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2467"/>
    <dbReference type="InParanoid" id="A8Q3P9"/>
    <dbReference type="OMA" id="TISLWMT"/>
    <dbReference type="OrthoDB" id="3038496at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727198" description="chitin synthase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="280" mass="32057" checksum="05E96D6FF1B15353" modified="2008-01-15" version="1">MWLYGFFLALQFILALGNRPVSETFAYMLSFTVFGVLGSYTLTISLWMTIRSLSHLAAENKPAVDIVLNNTTAVLIASLAAMYGIYLIASLLYLDPWHMFTSSFQYFFMAPSFVNVINVFAFCNLHDVSWGTKGSDKVDALPSVTTTQESQLSEDMAEEVALQQDDLDLRFKSVVERAISPIHSKRERIYPSMDDSNKTFRTRLVALWLLTNAILVAVIMNLYLFKPGENLGQEVEEGRHNQELYFKVTLWSTFGLAFFRFCGCVVFWLHRQCTRWSRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4E9</accession>
    <name>A8Q4E9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730150.1">
        <property type="nucleotide sequence ID" value="XM_001730098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4E9"/>
    <dbReference type="GeneID" id="5854457"/>
    <dbReference type="KEGG" id="mgl:MGL_2532"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2532"/>
    <dbReference type="InParanoid" id="A8Q4E9"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="447" mass="49154" checksum="B1D277A0DFF4638B" modified="2008-01-15" version="1">MHGTRAVQKTIDFISTPAQTQAIIDAFARNVVTLIKDLNGNHVIQKCLNRLPAGDNQFIYDAVAAQCVDVATHRHGCCVLQRCIDHASESQRQQLVNEITMYSLTLVQDPFGNYVVQYVLDLNDPVSTESVTNQFLGHVFQLSTQKFSSNVIEKCIRVAEPPLRHKLVAELVDPSRLELLLRDSFANYVVQTCLDYAEPAQRTHLVECIRPILPSIRNTPYGKRIQSKLQRDGSEPSRHRRSEQSRSSFAPSHHHHHHASRFGSTRFNQADAGHGSGHSSTHTSNSPLSQFHSTSNDHSHSQPIYSASPSASTSSPMMSSTSMPGAPSSRHGRSSHQHHQHHHHSSKRPDGLYYQQHHHASHHLPSHDSSANSTSATPSPTTSAYALAASASAPAEAAGNSSFLHAQDAAAPLYAPLQRMQLSNGIPSYEYHPDEKALSAHAGKGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4L3</accession>
    <name>A8Q4L3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-keto sterol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730182.1">
        <property type="nucleotide sequence ID" value="XM_001730130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4L3"/>
    <dbReference type="FunCoup" id="A8Q4L3">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4L3"/>
    <dbReference type="GeneID" id="5854489"/>
    <dbReference type="KEGG" id="mgl:MGL_2564"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2564"/>
    <dbReference type="InParanoid" id="A8Q4L3"/>
    <dbReference type="OMA" id="HAQENNV"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41603" checksum="4EBB3F497A07CBBC" modified="2008-01-15" version="1">MNRPIILVTGANAGLGLGVCERLLIQLSSTMPSDSGMLDDPKHNVASTPFHASEGCTLLLACRNQAKAREAVAQLESLLHRLSTTDDEYLEKHGLPSPAQKNTQPATASSPASAPAASTLSSTSSSAIDMSSTSSLRHRDMTTSRLNSPLDQRTREARKMYRTSFCKGTVIDVVPLDLASLESTKACARTITAKVPYLTHIILNAGGAAWLGVDWLKATWEILTNLHKAVTLPSFKLQRSGDKSSDDLGWVWQINAAGHYVLAKELEPLLCASPYATPSRVIWTGSLEANEADFHAQDIQCLDPQTSPRPYESTKYQCELLALGMDQRYTSSTQPHMPRAYTAHPGIVATSIFSGVIPAIMMVLMKLVFYLVRISPTCLFDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q693</accession>
    <name>A8Q693_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729903.1">
        <property type="nucleotide sequence ID" value="XM_001729851.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q693"/>
    <dbReference type="GeneID" id="5854210"/>
    <dbReference type="KEGG" id="mgl:MGL_2889"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2889"/>
    <dbReference type="InParanoid" id="A8Q693"/>
    <dbReference type="OMA" id="YTRKSMG"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1104"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1463"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="830"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="951"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1254"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1386"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1105"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1135"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1463"/>
            <end position="1490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1497" mass="167933" checksum="845F0A4BE81FF09D" modified="2008-01-15" version="1">MATPIREIEAGIDAVKEQTYAAGLLGQGLLEHQRMLEALLEELNDPSQGDQSTEIAERVQAELQDLQEQRDRMFHEISSTLTFAAPRPSITRQLQFGFSPSPSFKSREELDKLRQGKADAEKHFEAMKARVLELERKHEVFKQENWDLYVMQQQLEEKLASRSTAQSRAELDRQRLGKELEKLRESLEHQRAQFEENEEALRKLRKQRETEDASSRRERAGFRRNISDLHGQIKRLQSDQPAQVPALPAQIDEEVPETTTSNEHASNERSLRKRLSLQDGDSSHDTSGVIRDALPFNAEADELRSKLSMAIKRLGRDNQQQRKLREQISELRKLLTRAGVSPPAEEASEDGDDDDDEDDAWIMEAAEKPESPKPRRRLRRHAQPRIISRGPSSNAAVMPTSEWLDASFGDDSVIIREPNLDSTTANLLSDMPNASAENLKPFVGATAGDLGSELDAEGYSTKPDMLDVNTMTDVHPAESELQEARASFESDVQELKQAHQADMDGLRAKHEDELTSLSAAHEKVLQNKAAELASALDALRKDHASELQHTRNQHQDEMKAYGASQSEAVASIRSEHAKVIKQLEKKHFDALASQKKEHAKTLADLTKKHEAEAKSSTSKHTQALTSLKQQQEKEIATQRSELDAVIKKLEKEHETALASCKQTHEKATDDAKAKHDEGLRALKESHANELTRLKDQLSKAHAKELSEQEAKLRGALSDAEKRHDDALAQLQKEHATVLSSRGTEHNEMIAKLKNEHASALSTRDSEHEKAIATLKQTHSDALSSRGRDYEDAVTKLKEEHAAALASHEKTHEENLADLKAEHTSFVNSRKKEYDEAMAKLKEEHASLLATTGSDHAQSLTTLKEAHASELSSRSKEHEEAVTKLREQHASELASRRQAHDASIAKLKDERDQELSTLKKQHASELAARAKEHDDAVTKLKTQQEDTLVLRNRSHEEAIARLKDEHDRAISKLKEEHASALTAWRKEHDMALTELKEEHASALTARSQDHDKAISKLKEEHASALASLGKEHDKALAKLRKEHGSALASRNKEHSSALDQLKEGHASNLRAEVQKHEQVVSKLKDEHATALANRDRDQAEAISGLEAKHREETRSLGDQHAKEQANMNKKLKEMQEQSSRNSQQLTAMREEHAAELEAKANEHKDAIASLEGMHVDARKELEKTHAAELEQTEAKLSKALEAKEKEHANALATLSEKHAAELDAQRRAFAEDRATWDQKQASSEDAHVSAITKLKEELAAKIAHHAKDVEALQQLNEQHARQIEDLIAKHKVELATRDKTHEDAKKALQTALDESKAADLHAMEEKHATEMQAMKDEHNRALEEHKLALDAQHAREMASLKQRHEQELATQIASREKALSSDKQAVLDEARKAVDALKKAHAEELAQCDARLRSELASLEERLRSQHTQAMASLRDTHEKALVELKRHAADELAAATDALEKQRVSELEEQRRVAARSTRERARCPADRARTGAPVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6H9</accession>
    <name>A8Q6H9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2972</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729986.1">
        <property type="nucleotide sequence ID" value="XM_001729934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6H9"/>
    <dbReference type="FunCoup" id="A8Q6H9">
        <property type="interactions" value="780"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6H9"/>
    <dbReference type="GeneID" id="5854293"/>
    <dbReference type="KEGG" id="mgl:MGL_2972"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2972"/>
    <dbReference type="InParanoid" id="A8Q6H9"/>
    <dbReference type="OMA" id="FNAWDTA"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="216" mass="24305" checksum="7BA87FDF7C621741" modified="2008-01-15" version="1">MSDAQNIPNFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLQFHTNFGPIVFNVWDTAGQEKFGGLRDGYYIQGQCGIIMFDVTSRITYKNVPNWHRDLERVCENIPIVLCGNKVDVKERKVKTGAVTFHRKKNLQYFEISAKSNYNFEKPFLWLARKLVGNPALEFAAAPALAPPEVQVDQNLMEQYNKELETAAAAPLPDEDDGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6K6</accession>
    <name>A8Q6K6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_2994</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730008.1">
        <property type="nucleotide sequence ID" value="XM_001729956.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q6K6">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6K6"/>
    <dbReference type="GeneID" id="5854315"/>
    <dbReference type="KEGG" id="mgl:MGL_2994"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2994"/>
    <dbReference type="InParanoid" id="A8Q6K6"/>
    <dbReference type="OMA" id="AVCPPYN"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="224"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP42794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1376" mass="153867" checksum="04A877C2835C8198" modified="2008-01-15" version="1">MSKQEIVNLAELEVVTRDIYDLPNRDPRRGGVLDRRMGVSDKVSTCETCGQRMADCVGHYGYIKLVLPVFHVGFFKHVVSILQMICKSCARVLLEEPDRRRFLRRFRRPGLENLQRAQTFKAVNAAARKMLYCPHCGSTNGTVKKAGVLKIVHEKFRQKKTEEEQLEFRKTFSTAVSMGNGELAPHLNKAQEDLNPLRVLDLFRRISDEDCELLALKPQFGRPEEYIWQYICVPPVCIRPSVAQDGATNEDDLTVKLTEIVFTNNIIKSGLTKGSKGTTTAQLVEQWDFLQLSVALYINSEMPGVPPMSGHKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLAIDEIAVPERVAKILTYPERVFAHNIEAMRQAVRNGTDTHPGANYHVNGRDGFKRFLKFPGMRDDIAANLRVGDIVERHIRDGDIVLFNRQPSLHKLSIMCHRAKIRPWRTFRLNECVCSPYNADFDGDEMNMHVPQTEEARTEALTLMGVKHNLVTPRNGEPIVAATQDFITAAFLLSRRGRFFTRAQFVQICSYFGDASLHIDLPPPAILKPVRLWTGKQLFSCMIRPNKQSPVLVNLEARCRTFEKPRDGHVNEMSPNDGYLVIQNSEVLCGVMDKATVGDGKKQSVFGVILRDYGPDAAVASMNRLAKTCARWLSNQGFSLGIGDVTPGQHLRETKDRNVEIAYRQCRDLIELAKRGKLENLPGCDQEQTLESKISGVLSSVRSDVGEICMTELSRHNAALLMSVCGSKGSKINVAQMVACVGQQIISGSRVPNGFQDRSLPHFPKKSKDPPSKGFVRNSFFSGLEPTEFLFHAISGREGLVDTAVKTAETGYMQRRLMKALEDLSTHYDFSVRNSEGGVVQFLYGDDGLDPAELEGNALPVEYNRTFRHASAKTADVPSRYLLPYEVMDLVNHLLSQDRFERVCTSKYIDQVREFCYEQVAKRMAETREAYGMYPALERDGDWDVDTDLSLGADDAQRAVVENKVRVSEATILEFINLCWDKYMRAKIEPGSAVGAVGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINAAKVINTPIIAATLVSEKSEQAARIVKGRIEKTYLGDVASVIEEAWSGTYTYIGIDIDTAAIQKLQLEVTLDDIKRAIVAMPRMKIKEERIIVLPNQDRLQIYIHPDEKEKDVYYSLKQLKRQLPKVVIKGIPHASRAVISDEKGQRKLLVEGYGLREVMTTEGVVGTHTHTNHVMEMQQVLGIEAARSSIYREIDYTMASHGMSIDPRHVMLLADVMTYKGEVLGITRFGVAKMKDSVLMLASFEKTTDHLFDAALFGKSDSISGVSESIIMGNPAQTVGTGMPALVSQKPTLAPPRQLVFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6L6</accession>
    <name>A8Q6L6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730016.1">
        <property type="nucleotide sequence ID" value="XM_001729964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6L6"/>
    <dbReference type="GeneID" id="5854323"/>
    <dbReference type="KEGG" id="mgl:MGL_3002"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3002"/>
    <dbReference type="InParanoid" id="A8Q6L6"/>
    <dbReference type="OMA" id="DWQRGAM"/>
    <dbReference type="OrthoDB" id="3366139at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="524"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="664" mass="73031" checksum="45B5074260352EBC" modified="2008-01-15" version="1">MDDAHLTPGPVHSVRHDQHELAVRRKRMLDEDEDTDHELITPKHLRESYEPRQHVALVGSELRPAVFNMPSTVASRLSERASPTKPKRAPLLFSPRDLEHSQRAAHRMEQVLALPYVLDAQLDLPTSFQQLIIYHKAVEHSLLVHMATHGAPAAEPCTPSSRQQVVIPNVLTFQRLRPLVERTCRRSFSVADFRRLVWLWSHAPDTPDMPGLHTGGMGFRISRVSTVDMHTSRRMYDWAIGIEMSLHRIRAPPLKVHYGPSQNGTKSLERPHSPLQTPAKSPTASSPPQTPSRDDLSHLAVWNAGIDERHMEIKYRLTHLVAAAHAQWLGGHPEKSLDACLESGSPSSHEALALAVSSKIDPSTVRTPGAALAPPLTPTSTSKPRSMAPQGYNTRESGLLTPAASRSSDGHAKRVVMDVSELSPPASPLAARSQHLETPMTPPSPSMHGSSPSLRRVSRRLVRWHPDFSLDSLPPIPLAQLPPLAALPSELTKSTSTTLSSMSASAQSPMSKVVSTPVQARPQSLEERIRAKEQAIRASTQASNSMSALQERSVLSRLGEMADAIYVLYTSLPSTQAAHGDRRSSVLPLNDVLASLEKSARVAMSRAESRACLDKLMHIVPGWLEPCTIGSRTWLKLHHDAAPGRGLREVREKIHAAMTKSTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6N2</accession>
    <name>A8Q6N2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730029.1">
        <property type="nucleotide sequence ID" value="XM_001729977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6N2"/>
    <dbReference type="STRING" id="425265.A8Q6N2"/>
    <dbReference type="GeneID" id="5854336"/>
    <dbReference type="KEGG" id="mgl:MGL_3015"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3015"/>
    <dbReference type="InParanoid" id="A8Q6N2"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="199"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="398" mass="42690" checksum="E72FEDD840783A90" modified="2008-01-15" version="1">MRGKLDIRSHRTHASAPVLLEAVSMSMCECVPVADNSTDTARSIKRVADTSHVPRQLSYHTCSLPSVYPALDDNSTLAAASDSSILSKASRRASTASQNTSFHVGHGSSSDPESVSRRLSQVTVEGPFTCMHEGNSSLSLSPVERKSSRLLAVSPLSRSPTNVDAGGCDERSVMAWHSSSDASDVLVECNSEYSESSSSSKRKSFLERNRQAALKCRQRKKAWLASLQARVDFLESENNSLRTTVEALRSEVVFLKSQLIHTHAMGTTMSDTAPNESLPSLSRSSMSTAAPYGSVHLEPSPEFGDSTPAATSSSSPSSMATTLMPPNPLVVYATDPNFSPRVLSSQAVTHGAGIPSITHPMDGYDARDMHRFVQLRPNGAMASSYAASTPYLASRSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6V1</accession>
    <name>A8Q6V1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730074.1">
        <property type="nucleotide sequence ID" value="XM_001730022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6V1"/>
    <dbReference type="FunCoup" id="A8Q6V1">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6V1"/>
    <dbReference type="GeneID" id="5854381"/>
    <dbReference type="KEGG" id="mgl:MGL_3060"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3060"/>
    <dbReference type="InParanoid" id="A8Q6V1"/>
    <dbReference type="OMA" id="WPAINTH"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="377"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="729" mass="80316" checksum="C531097FA9AB4386" modified="2008-01-15" version="1">MAMLRPSKRRESASALMDTPNNASSTVASSTTDHMTPSSSLTSTQVTSPVPSSMSTNSPIGTAPGRRIMYGMGQNASTTSSLASGSSVLITGPSLGMLGDVLDKQPAHLPHLYSKYDDHWIRRVASAPDTNALYQATPAPPVFQGWPAINTHDGVPHAPDSVSTSPRLEGSSDLFHGYTQDALWNVSLQTQTLPLPHSQSHIQLHTQPSRLQQPTQPMTASQQQVLRNMSPPPPPLSATTSPTESTHETSVPTPWESQSAIGKGSSPLRLQPAAQIDAIPATHMAEPISPRRTRFLPSLRIAPKSRQASDNTNDAPMRRLTRLFKSKSSGTLQADATKAEESRPPMPTTVTTATTAATLRTTSRVKTSDVLVSIDEFQTIKLLGKGDVGRVYLVRHRQTDTPYALKVLSKAEMKKRNKVKRVLSEQAILIASNHPFIVPLYHTFQTTDYLYLCMEYCCGGEFFRALQSRPGRCLSEDDARFYAAEVVAALEYLHLMGFIYRDLKPENILLHQSGHVMLSDFDLSAQAHEQVAAPAVFQASPRAAPMVDTRACIADLRTNSFVGTEEYIAPEVIKGCGHTSSVDWWTLGIFVYEMIYATTPFKGTSRNTTFANVLRKDVSFPDGVPMSTSGRNFIRKLLVKDEHKRLGSQLGASEVKQHRWFANISWGLLRNQTPPIIPDSQQLSTLIQEAEAKPVRSHEWEHQTVLDMKKYDATPFHDFRNVSILRTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7I2</accession>
    <name>A8Q7I2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729530.1">
        <property type="nucleotide sequence ID" value="XM_001729478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7I2"/>
    <dbReference type="FunCoup" id="A8Q7I2">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7I2"/>
    <dbReference type="GeneID" id="5853836"/>
    <dbReference type="KEGG" id="mgl:MGL_3074"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3074"/>
    <dbReference type="InParanoid" id="A8Q7I2"/>
    <dbReference type="OMA" id="WIEGPEP"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="284" mass="31198" checksum="5D3D3A1FE8C5251B" modified="2008-01-15" version="1">MKNRFESQRKNNEKKKKSSASKKKQSTKNDASSDKYGPLAHLDFPKGKGHHAFGGEMQPGMFGSVKDRKVANPAPLGLCGVAFSTFIVSLINVGTLDLKNFSVLVCIGFVYGGLIPILAGMWEMAIGNTFGATTFTSYGAYWISYALLVMPSQSLNIMEAIKKAEGGHGELQTIGLYFMGWFIFTTLMMMLTLKSTVAMFLMFFSLDLSFFFSGVSHLYNDGISPHIPLLRLAGAFGLVSSFSAWYNALSGVADNTNSFFVVPALRFPWTSGYRQKKLDKSQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7T2</accession>
    <name>A8Q7T2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729568.1">
        <property type="nucleotide sequence ID" value="XM_001729516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7T2"/>
    <dbReference type="STRING" id="425265.A8Q7T2"/>
    <dbReference type="GeneID" id="5853874"/>
    <dbReference type="KEGG" id="mgl:MGL_3112"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3112"/>
    <dbReference type="InParanoid" id="A8Q7T2"/>
    <dbReference type="OMA" id="ENGHIAH"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="480"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="823" mass="92359" checksum="7B7A447B6B039C4F" modified="2008-01-15" version="1">MRVSRSSTPHSASDHAWHPLLRSLWPWRRPRAGTKPRSSQTTAGHAARALTAVLAQQYTPSEPTLILQHDDATIRTIATARPLTPASAWSGAGAAAAMTSADDDELPLSLPRPASTASPDAISHSRTVNPMNPRSAHLDRSAILLRWQHVFLERGTRHGIKWWSMSSPACLPLTTRYLPSDQELATSWHEYPYTVSVHSDTTSIMLKRDASSSPALMMLLEMCAQRLSQGFQLVERVVARPDAAPGTRDASHLVVRQPTELLRPGNFASGEPIYLSSMNQVHCITYKRQEGMINVTRYVQKVPYSTAPIPYRCCVWPRSQLGYRITSTQFQHPDPHAYNWTYLDSMIAGYEDTFTESLLYWRARFVLVPSEGSPNKILANAGEYLSDEEVRLAGMDRLADMFARVEYRAPGEPKSEVPLRFLPTTLDPSSSLRDDAFIHAITELYDELTKRKCSSDARSRTQRDATSCTLAQLADDMRSSSKELKIHTRLWHSELYPDAFTGADLVTWLCRTFRDIHTREDAVLLASKLQENGHIAHVLNVHGFMDGHYFYRLTGRGESAEGTTRSTRKPPTAGSGASPSARSRGKANVLHPGTRQVSSPPRPNHRRVPLSRSMLIDVDPGRRSPRSEVAVLHHDLAHNAENGFNFQIHWLGATARLIDELVQTWTRTVERYGLRLVEAPIAQIKDVGQNNPFQAPMPIALALAPPKRSAYAALLERARHAKNASMPDDHDYMETWLVRHVLSQCTSTSHTNPLFEVALLRHFGFVLDQEAKSMYPDDMDFYYSSRPNNFDYTQFVHRSGVAFVQIVGGRDGFLWYVSPLCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7U1</accession>
    <name>A8Q7U1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729577.1">
        <property type="nucleotide sequence ID" value="XM_001729525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7U1"/>
    <dbReference type="FunCoup" id="A8Q7U1">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7U1"/>
    <dbReference type="GeneID" id="5853883"/>
    <dbReference type="KEGG" id="mgl:MGL_3121"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3121"/>
    <dbReference type="InParanoid" id="A8Q7U1"/>
    <dbReference type="OMA" id="IGTMSEQ"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="83"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="294" mass="33568" checksum="4DD1C7C72C18C9B3" modified="2008-01-15" version="1">MLRRQARERREYVYKKALESKQRQIYERKQKIREALASGKPLPPELRGPEAEALAKNLALDAAQEEPLTSIDDEYSRAGQYDPRILITTARSPSSRLSQFAKELRLVFPNSTRMNRGTYTMPELAAAARSNGITDMIVVHEHRGVPDAMVVSHFPHGPTVMFTLHNVTLRHEVASHGNSTVSEQFPHLIFDGFGGRLGERVKSALRFLFPVPKDDARRVMTFANRNDFISFRHHVFVATHRDVHLAEVGPRFDLRPYEIRLGTLEQSEADVEWVLRPYMNTTRKRSQLTGPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7Y6</accession>
    <name>A8Q7Y6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729615.1">
        <property type="nucleotide sequence ID" value="XM_001729563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7Y6"/>
    <dbReference type="FunCoup" id="A8Q7Y6">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7Y6"/>
    <dbReference type="GeneID" id="5853921"/>
    <dbReference type="KEGG" id="mgl:MGL_3159"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3159"/>
    <dbReference type="InParanoid" id="A8Q7Y6"/>
    <dbReference type="OMA" id="LEDMTWE"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="91"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="167" mass="18639" checksum="A112519BD4DE440A" modified="2008-01-15" version="1">MNHDVSTSLSSSCDAYEVLGIHPSANASEIRAAYLRLAREHHPDKVRSHSQGGEQMQRIVQAYEVLHDTVSRAYYDEERAAKQRRNVPVRIAETVPLECMEAVEQPTMHFQYPCRCGQAYVIAPDALVQENGYVGCMGCSETIHVVWDEDSDDDGDSGPGERIENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q806</accession>
    <name>A8Q806_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729630.1">
        <property type="nucleotide sequence ID" value="XM_001729578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q806"/>
    <dbReference type="STRING" id="425265.A8Q806"/>
    <dbReference type="GeneID" id="5853936"/>
    <dbReference type="KEGG" id="mgl:MGL_3174"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3174"/>
    <dbReference type="InParanoid" id="A8Q806"/>
    <dbReference type="OMA" id="DMADNYL"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="219" mass="24052" checksum="D1523C332765E8D1" modified="2008-01-15" version="1">MDLDDLLKNSHGKRTVENLQERLPQLSPEQAQSEALRFEQRIIELSDENRAKATKEPTADDPQGSIVGLPGVKDLLSQLNEGPKQDPQRNPGWAIVTSATGDYARRAFLSTKSSELPKVFVSADDVSKGKPDPQPYAKGAELNHVNITNCFVVEDAPAGVLSGKRAGARVLAVKTTHDAERLWRQGADFVVDNLTKVKARWSGNKIVLTIDSELRPSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q812</accession>
    <name>A8Q812_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein Bfr1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729635.1">
        <property type="nucleotide sequence ID" value="XM_001729583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q812"/>
    <dbReference type="FunCoup" id="A8Q812">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q812"/>
    <dbReference type="GeneID" id="5853941"/>
    <dbReference type="KEGG" id="mgl:MGL_3179"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3179"/>
    <dbReference type="InParanoid" id="A8Q812"/>
    <dbReference type="OMA" id="AHWKEDQ"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="54936" checksum="D8DC2D030450BCB3" modified="2008-01-15" version="1">MVDTQKTTPRSGTAPDAAAAAPAPADTLASGVSAVHIVKQPGGRPDQKHHNGEIERLKKEIDQTHAKIAQIRAALSGESTNDTPAGRRRAALKEELNSLRSEQAGRKGTRGKVFDELKQVQDDISNKVKALQQAKSKAPFKSTAELDAQISQIEAQIESGSMKIVEERKALNEVSTLKKSRKSVEQFGAQQKEIDTLRAKIDELRSLLDDPDMAAANKRYEAIKQELDDITKEQEKTVGSRSKLMSQRTALSKRLDELYQARRDRLSAYHHENDKYFARVQAERERRQEAIRKEREEAEHARQQAEVQQLRDDAAIPAFSKEIEDCDVLIRFFSGTSTEEQKKDETVAPTRSEGLPSLPSVPKPDAAVPEGAVVARKKGDEDDYFAGIGTGKKKGKGKKSGAASAATSSTTNASAGAAGDGDHSALNVPFGMLSALLNLSIPPPTSHADLGRVVDNIKLKREYFVSNQPHQTQENIRKAEEKIAALKAKLGSSSSETNNESHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8E6</accession>
    <name>A8Q8E6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729713.1">
        <property type="nucleotide sequence ID" value="XM_001729661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8E6"/>
    <dbReference type="STRING" id="425265.A8Q8E6"/>
    <dbReference type="GeneID" id="5854019"/>
    <dbReference type="KEGG" id="mgl:MGL_3257"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3257"/>
    <dbReference type="InParanoid" id="A8Q8E6"/>
    <dbReference type="OMA" id="IMGDDVP"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14812">
        <property type="entry name" value="bZIP_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="860" mass="89635" checksum="617DFC86D11EDF81" modified="2008-01-15" version="1">MSTLESSSRGGFSPLGSMFRSMEPGSSEFDAFIHSDLCAGSSGSQDVGGMNSFAFLPYAPPSLSKQDESAAVLSLWPGASGSTASSTASMMPADPPSSGAALRMPESSFSQSSLWASASASGTGSLGPSSCERSSGLGSASGAESTSHASASSSLPIDALATPAPPVGGSAHVPREHHDESPISANVSRHQDGMSSMSPGSSAYPPGQGAYMMRPGVAQHASASRSASVSAEASPALRAAPASTSAPTSASAVASSIPGIPSTARSLDLPIKGEDDVGTSPSPSTSSITTAKTTNTAPLSASTTASTVLAGLMGEGKCMPLHAPTSNGSSWFHGMEQNNAVLSGPPPTKRSRSSESPERKTRSVSAMDPGSMDPTRARVLPPPRRSASTGARRPPPSASQVTESGLPFPVIDTSAKHSSLFVPPDTSGLTKKEARLVKNRAAAFLSRQRKREQFDELASKCRSLARLSWLLWDALGHATMEPASRMAMMATHGGIEQVIQTTLLRDKLKYESEDVWTTLQQVVQQHGSMIVEGIMGDDVPPLKTRTNEMVAQLAATQKECDELRAEVQRLQSGAMATTPAQAFSSGDIKALPGSQMRASPIQSATTQIPGQGPGSLVSMPTSGASPAAESLVQLVGRALIQLRHATPDCDAHELLPRDDGSLQLRMSVSPTSDVLLCTLASESGGTDSSVHADELDDKQWRCSTPIESSEAASVPSLSTSTSPSLSSLSSGSAFSRRHRHVIAYYTGTERSASFMHELHALDLNEWVSQYGTALGGGQPDHISRAVQDLHTRLLQRRLGVQPGCFLAASYEHDAGKNSPCRLTLYAKCVATPESMETHAHFVSAVRDTLGALHHEPTQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8G4</accession>
    <name>A8Q8G4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729722.1">
        <property type="nucleotide sequence ID" value="XM_001729670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8G4"/>
    <dbReference type="FunCoup" id="A8Q8G4">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8G4"/>
    <dbReference type="GeneID" id="5854028"/>
    <dbReference type="KEGG" id="mgl:MGL_3266"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3266"/>
    <dbReference type="InParanoid" id="A8Q8G4"/>
    <dbReference type="OMA" id="AWHQIRI"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="331"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="625" mass="69205" checksum="678ED43435C8F374" modified="2008-01-15" version="1">MPRGVRVTPSRPGRREGWDDDEAWASNSDDDEFVTRVATEPVSLPAERHQHYMAPAPTSHGAWTLMTSDMYDAHPADARSGTPSVPYGAAESTLERSPHASTSATLSARLAAPRVGAAASASQRIVSPSATTDDADGHVVHWAERSIAMTTSPHLDTRKNGYLEAVVEDPLNLLPKSKMLTYTMSIPAPSQPATPKQEEPLAPASQPTEDVAQSFLIAWVGAAAFDPIATMNDGVFTTPMSPETLPYVSTAPKSNTTSSARNTASNTPLSSSSTPASGAPPPASRAASADAESGLERRTSTRTIRNRERLEQCLQNDNIDLAALRSLAWKGVPSDLRPIVWPLLLGYLPATSSIRTATLARKRAEYMSGVDRAFAHGTESLDRAAWHQIRIDVPRTNPGLRLWQQAETQRALERILYVWAIRHPASGYVQGINDLVTPFFEVFLSAYIDSDPETFEFASLPLYVRQALEADTFWCMSKLLDGIQDNYIFAQPGILRQLSIMADVVKRIDAPLHEHLAEQGVEYMQFSFRWMNCLLMREMSVKSIIRIWDTYLAEGADSFSEFHPFVCAVFLHRWRKELLRMDFQAIIMFLQSLPTQHWSDHDAEMLLSEAFMYKSLFGNSAHIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8V8</accession>
    <name>A8Q8V8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729310.1">
        <property type="nucleotide sequence ID" value="XM_001729258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8V8"/>
    <dbReference type="STRING" id="425265.A8Q8V8"/>
    <dbReference type="GeneID" id="5853608"/>
    <dbReference type="KEGG" id="mgl:MGL_3345"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3345"/>
    <dbReference type="InParanoid" id="A8Q8V8"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="97" mass="10802" checksum="585DC7F1C632201C" modified="2008-01-15" version="1">MLPVSRHPPAHRDKPDAGYLWGLRCLSLALHEIWDRERKRRLDASLASLHEHATAEDRLSSLRTADIGPLQVPGGEIFLQLFGDYHASGSLSGYIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8Z5</accession>
    <name>A8Q8Z5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729341.1">
        <property type="nucleotide sequence ID" value="XM_001729289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8Z5"/>
    <dbReference type="FunCoup" id="A8Q8Z5">
        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8Z5"/>
    <dbReference type="GeneID" id="5853648"/>
    <dbReference type="KEGG" id="mgl:MGL_3376"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3376"/>
    <dbReference type="InParanoid" id="A8Q8Z5"/>
    <dbReference type="OMA" id="NHNTHIN"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="116"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="254" mass="28167" checksum="16731376E66E3D51" modified="2008-01-15" version="1">MSASSAEVPDLGAYTSHTQPGAHDDEDDEVFAELEREVEALNEADADEAAHITGNSSGRSTDGDLSKAFQEYRAQRLAEIHTEVAARAGADASDPDSGKYKEVRDEKELLSMSVREPNVVIHFAKPEFRRCRILDRHLEHMARQHPSTLFLKADVERTPFLVNKLEIRVLPCLFVFKNGVCKDKLIGFQEFGNSDVFTTAALEWRLGQTGKHKRTGPPHTTGVIVPQQKPNNPILGFGVPQSSQNAMASDDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q998</accession>
    <name>A8Q998_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="1 7">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="1 7"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729405.1">
        <property type="nucleotide sequence ID" value="XM_001729353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q998"/>
    <dbReference type="STRING" id="425265.A8Q998"/>
    <dbReference type="GeneID" id="5853712"/>
    <dbReference type="KEGG" id="mgl:MGL_3440"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3440"/>
    <dbReference type="InParanoid" id="A8Q998"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="289" mass="32680" checksum="53493C851E83DEED" modified="2008-01-15" version="1">MPNLPNSQYACKRLMPRYHMQRLYKELRYEGNHGTHAHLRITPADVGKWYNPLDLFSADAKRIEKAVQALTADWTHDAGHMRVFIDGKCVTYTQAKKHVPHIDTDEGLRMFARRVTNTLMESENQALLTELKWQQERLDPYDIEGIAAIWRHVTGTDLATVPLNVLPKVALSDYMWIALHAVPSVILPRSSSGDAEVGDANATEHRMICEPRTLRYVLAAYLLAATLKDVTLFVPLKPNAASRRPVSVVDLDAKRVSKLQRHVKQDNAVAVLATQWLQKADMCAPRNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9A1</accession>
    <name>A8Q9A1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729407.1">
        <property type="nucleotide sequence ID" value="XM_001729355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9A1"/>
    <dbReference type="STRING" id="425265.A8Q9A1"/>
    <dbReference type="GeneID" id="5853714"/>
    <dbReference type="KEGG" id="mgl:MGL_3442"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3442"/>
    <dbReference type="InParanoid" id="A8Q9A1"/>
    <dbReference type="OMA" id="FWMPDLS"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="20382" checksum="59BEA919BEA58A4E" modified="2008-01-15" version="1">MHPNSRHAYQKARVMLRQRRLSEAKLARQRQRSAKVDRIMAFVLLLSEDKTHLPDLYSFHDFMTTFFLARHDQELAALQKEHRPGRAKSKRLAELENLIASEKREYHDGIDVPDLCDEINVGLLRQWEGDPQALPLFRFVRISGQYRDTCRVIQHGTHKLLQNDKGKSSNDESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9I1</accession>
    <name>A8Q9I1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Component of the lid subcomplex of the 19S RC.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729450.1">
        <property type="nucleotide sequence ID" value="XM_001729398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9I1"/>
    <dbReference type="FunCoup" id="A8Q9I1">
        <property type="interactions" value="449"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9I1"/>
    <dbReference type="GeneID" id="5853757"/>
    <dbReference type="KEGG" id="mgl:MGL_3485"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3485"/>
    <dbReference type="InParanoid" id="A8Q9I1"/>
    <dbReference type="OMA" id="RLHCKVD"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="194"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="389" mass="44113" checksum="3E7E0CF9CA6FEC8A" modified="2008-01-15" version="1">MEDDSITPIPNPVVQQQVFLLQRDGSSESTQRQALEKLLHNIDQDEMAPYLTFLLSDARIAAHLPQNEDRLQELRAKNENELARLEALQKQAEDSEGDVELHTVLKQRAMYLARIGDKDGALPAIDEAFAKATGTGSRIDLTLLKIRLGLFYGDTDLTQASMTIAASLIEEGGDWDRRNRLTAYRGVYAASIRDFETASKLCTEALSTFTATELIEYLEFVLLTILTSMVSRSRRELKKLMESPEVLQAIDDLPFMREYTSALYNSEYALFFRTLAEIEQRYLLPSRVLSRHTQYYVREMRIISFSQLLESYRSVALDSMAAAFGVSSDYMDQELSRFISAGRLPAVIDKVDGIIENRRPDQKNAQYGRIIKEGDVLLNSLQKLSRTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9Z4</accession>
    <name>A8Q9Z4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729104.1">
        <property type="nucleotide sequence ID" value="XM_001729052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9Z4"/>
    <dbReference type="FunCoup" id="A8Q9Z4">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9Z4"/>
    <dbReference type="GeneID" id="5853411"/>
    <dbReference type="KEGG" id="mgl:MGL_3571"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3571"/>
    <dbReference type="InParanoid" id="A8Q9Z4"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="140" mass="16082" checksum="21C361391C0B7118" modified="2008-01-15" version="1">MFEKYPWGTLAVTNGLLTAVADGLAQTFDRRSEGKPLLEWDFPRSSRFLIFGSAMAPLLAEWNHFIEHKFRIRGASGSLIWSGLMRRVMTDQIVFAPFGLALFVGAMGIMEGRHSFETLKEKYNDVRKESTYSRYTFQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAJ6</accession>
    <name>A8QAJ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729288.1">
        <property type="nucleotide sequence ID" value="XM_001729236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAJ6"/>
    <dbReference type="FunCoup" id="A8QAJ6">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAJ6"/>
    <dbReference type="GeneID" id="5853594"/>
    <dbReference type="KEGG" id="mgl:MGL_3755"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3755"/>
    <dbReference type="InParanoid" id="A8QAJ6"/>
    <dbReference type="OMA" id="WTCRIKE"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="179"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="454" mass="49684" checksum="8B00FE9841F7F54D" modified="2008-01-15" version="1">MPVYDAQGNRRPLVQYAIMMDAGSTGSRIHVYKFNYCKASPELEFEHFDHIEPGLSSYGANSNAAAQSLRPLLDKALEIIPSSLHRCTPVQLKATAGLRLLGPEHSTAIIDAVRTMLADSYPFPIADGINNQGMLTSNGVEIMDGRDEGVFAWITVNYLMKLIGSGGKKKTAAVMDLGGGSTQIVFEPQLHPSEPMHPGEHVYELKNFENVSFTLYQNSYLGFGLKQARQSANSLAAFTHLTSHPDAVKHLDDISAWDKFTPESTFIPSPCYAAGTQKTAKVAMGKSKGSEVTMLGTSGGFRACQRLIEVMMDKDAECYAAPCSFAGVYQPSLSQTFKNAEIVALSYFYDRIAPLGLGPTFSVKELEQLAVRACSLPSQWSSFKSPAFSPEALSELQKRSDYCLDLTYMHTLLRLGYELEDSRKITLAKKLGNFELGWALGAQLAVLQQGVLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAM7</accession>
    <name>A8QAM7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MTHFR SAM-binding regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728998.1">
        <property type="nucleotide sequence ID" value="XM_001728946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAM7"/>
    <dbReference type="FunCoup" id="A8QAM7">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAM7"/>
    <dbReference type="GeneID" id="5853305"/>
    <dbReference type="KEGG" id="mgl:MGL_3786"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3786"/>
    <dbReference type="InParanoid" id="A8QAM7"/>
    <dbReference type="OMA" id="GLMPINS"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="332"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="589" mass="66093" checksum="17BC196BD2D2B24E" modified="2008-01-15" version="1">MSQAEAQLSARIDEKLNDSTQDAYVWSLEFFPPRTALGLANLCARVARMSEALQPGWVHVTWGTGGSTRDASMELAARVQKGVYDPLEDYTNVKERRKGACDVCLHLTCTNVERAYLDATLDEARQIGIRNILALRGDPPRSDEYWVATDQRLQNATDLVRYIRERHGDYFCIGVAGYPEGLKQGIDCDMRHDIKVLKAKQEAGAHFIVTQLFYDVDALVRWTKECRAAGITIPIIPGIMPIQNYTMFRRMANLCGVHTPEDVLEQLEPIKMDDAKVKEHGIHLSIDMIKSIREQTGIRAFHLYTLNLEKSATCVIKVLADVPDQSASISGSVTWDEFPNGRYTDARSPAFGEMDGYGANLKVPPEEAVRLWGTPVDEDDISSIFSRFVDGRLACMPWCDIPVWDETMQLLPALLHLNSPPSAGGKAWWTVGSQPAVDGCDSTDPTFGFGPQGGYIFQKAFVELFMNENDKNALVQMIQGSSTPVTYFAGKCDPTTFETNLTTNGLNTVTWGVFPGTEVAQSTIIEEASFRAWRDEAFAIWREWELLFPPNSATRSLLRRIHDERWLVTVVHHDYKDPQGLWRLLETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAS8</accession>
    <name>A8QAS8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729035.1">
        <property type="nucleotide sequence ID" value="XM_001728983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAS8"/>
    <dbReference type="FunCoup" id="A8QAS8">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAS8"/>
    <dbReference type="GeneID" id="5853342"/>
    <dbReference type="KEGG" id="mgl:MGL_3823"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3823"/>
    <dbReference type="InParanoid" id="A8QAS8"/>
    <dbReference type="OMA" id="RVHNTME"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="199"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="306" mass="34504" checksum="DB748009909EF7A7" modified="2008-01-15" version="1">MSFNDLEQGRLVPDEPRHQLSEDSGHEASRVESQAFMHLTEQVGLHVFRINANVATLEKLDADLRKATDGDQSKTDKIMKHFADLCEQTRSIVKEATEDVKSLSRFPVGGTGGAVRRTSPSRLMQVKLQHDFQDALAAFQKIQKSGIRKEKVALAHAKQRGNEANSLETQSENQPQLQEQQQTQVHVSRLTNEEIEFQESIIAEREAEIREIEQGVQELNEIFRDLSHIVQEQGGMIDNIEYNIGNISTSAQGADRELLRANTYQRRAKHRGLCLTMIVAMVVALVLVAVRIVHLTISCWDSICEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAX6</accession>
    <name>A8QAX6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729061.1">
        <property type="nucleotide sequence ID" value="XM_001729009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAX6"/>
    <dbReference type="FunCoup" id="A8QAX6">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAX6"/>
    <dbReference type="GeneID" id="5853368"/>
    <dbReference type="KEGG" id="mgl:MGL_3849"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3849"/>
    <dbReference type="InParanoid" id="A8QAX6"/>
    <dbReference type="OMA" id="ANCMHAL"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="660"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="696" mass="76676" checksum="B1402FDC381591E8" modified="2008-01-15" version="1">MTVGKDVSALFPDVLKNMQTEDLEQKKLVYLYLMNYAKTQPELVILAVNTFVKDAEDPNPLVRALAIRTMGCLRAEKIIDYLPVPLNRCLNDESPYVRKTAVLCVAKLFGLKAELALEGGFVDRVKEMISDNNPMVVANAIAALNDIHEAAQDLKIQGEPVFVLDSDVLMKLLVALNECTEWGRIIILNTLATYRSADERESEHICERVMPQFQHANGAVVLGAVKVVLVHMESTRKPEFVQQLVRKMAPPLVTLVTSEPEVQWVALRNINLILQKYPDILSNEMRVFFCKYNDPPYVKAEKVDVMIKLAKESNVDMLLSELKEYATEVDVDFVRRAIRAIGQCAISIESAAERCVYVLLELIGSRASYVVQEAIVVVKDIFRKYPHQYTRIIPQLCANLDDMDEPEAKASLVWILGEYAEQIDNSDEQLAYFVEQFVDDEPEVQFQTLSAIVKLFLKKPESPLAQRIVQDVLEKATSKCDNADLRDRAFVYWRLLSSTDTDAARAVALVPAPLISVPLTTVPRSLLNELIRELSLLSSVYHKPASTFIGRGRVGMQSLQALYVASIPSFLTNHRCSSNDEAARTRAIVTVAQGEKSETLLDLGEDTSSSTAAQAAAQSLGSLGDLLGDDAFSTPAMTNTAQSVPQKGAMDDLLGIFDTPSQSAGLSQPTASAAAAAPSTSSSTSSAQQNDLLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBA6</accession>
    <name>A8QBA6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728901.1">
        <property type="nucleotide sequence ID" value="XM_001728849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBA6"/>
    <dbReference type="FunCoup" id="A8QBA6">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBA6"/>
    <dbReference type="GeneID" id="5853206"/>
    <dbReference type="KEGG" id="mgl:MGL_3895"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3895"/>
    <dbReference type="InParanoid" id="A8QBA6"/>
    <dbReference type="OMA" id="FMAQGED"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="428"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="720"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="763"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="838"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="873"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="838"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1101" mass="118604" checksum="9C59D7E84A4FD180" modified="2008-01-15" version="1">MRCLGIAEALYDYAAQADDELTIAEGDKLYLDELVDEAWYKARPRSGDRQGQGLVPANYVEICAPEQVVVALYDYEAQGDDELTFTEGQVLDVLERDGEWLLARKQSTPEVGLIPSNYVEMQGDGQADEGAAALTASSVDPNAGSTAAEPKPEPEPELEPEPERLPASTTTSSPSAAAAATTTTTTTTTTTAASAAPANATSESQPKRTRTVAPPPPFPTSAPSAPSAPAVTAASASAPAPAASVPLPSEIVPQVTGIDDEMDETDGQTSTVAPRAVPASWTSSDSSKDEIQMWSVTEVDPKKRKRKNKGTLGVGNACMFFATDADGAAVPRVDIRHVKSTTLEKNKYLLVTLDPAANIDGDTWAFHVGSRTAYQAISARIGESKSLAMSSSTASSARNQPSSSVSRMPTATTAGSVSSSAAVASPRPAQEMVVVLYDFDAQADDELSVSEHDQLVLVERENHEWWKLQNASGQVGVVPAAYVQLLQEHNTPDMRALNEKYSTMRDPRRSAPRLPVDRRDRAHDQRGMPDPRATQAPLQALPPAHSAGRMRTWVDATGKFRVDAELIGVRRESVRLLKGNGALIDVPLAKMSLPDLRFLEGITGRDLVSPPPARASGGHDPHDALRHERHVHHRAHEREREREREARRLLQHQYRPDIDWFEFFLEAGVDMNYCSRYADTFERDHMDRSVLTELEPDTLRRLGLREGDILRVRRHIHQKYANKTTSQSMSARSSSGAPVSEEDQTRQAREDEALARRLQAQEIAAQRRAAPRQPRSKDTDSQQSPQPLPPRASEDKQSSDAATIASTKDTSAAPLQPAQTGVDPETIAAAVEIIRRREREEAEEREKAAKKDERPADPNSALFDQLERLKPNAKPTTASAPSPSTPDPNAPRAPFAPVPVNQSLLQPLIPLQGTGNYVPTGGFASQPTGMMAPQMTSPFSMSSQPTGMYGVPQPMLFGATGTAPIPSSMQPPQPTIGAATEDTTGPIKQQDRFSAANVFEQMKTGTGAFASDNKPPSAPQSSSRYDALRAQPTGFAPGGIVDPSPFGGGMMMSQGMPSNMMNMQPISSMPTGGGMMMGMTGPGPSQQQSAAFMPMHGFYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBK1</accession>
    <name>A8QBK1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_3918</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728924.1">
        <property type="nucleotide sequence ID" value="XM_001728872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBK1"/>
    <dbReference type="FunCoup" id="A8QBK1">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBK1"/>
    <dbReference type="GeneID" id="5853230"/>
    <dbReference type="KEGG" id="mgl:MGL_3918"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3918"/>
    <dbReference type="InParanoid" id="A8QBK1"/>
    <dbReference type="OMA" id="CGGGNFK"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="55"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="326"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP41710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="542" mass="59626" checksum="9B72F6E0CE73428A" modified="2008-01-15" version="1">MEAQLDKLRALNASEAPAEAVAPELAALQSLSTQLSELSISKKNKGKITLKTPKGTRDWEPLAMALRKHVFATIERVFTTHGAVTIDTPVFELKEILAGKYGEDSKLIYDLQDQGGELCSLRYDLTVPFARFVAMNPTEYGNIKRYHIAKVYRRDQPAMTKGRFREFYQCDFDIAGSYDAMVPDAECLCVLVETLDALDIGSFTVKVNHRKILDAIFAVCGVPEDKIRTISSAVDKLDKSPWADVKHEMVEEKGLEESVADQIGTYVQQRGGRELIAKLQGDAVLTQNERAVEGLAEMELLYQYLDVYGVTDRLSFDLSLARGLDYYTGVIYEAVTALSAPPSMTAASSDNKDGSEKTKKKNVAAENGELDESTVGVGSIAAGGRYDHLVGMFSGSKRPDAVPCVGVSIGVERVFSILMQRIQEMQARGERSSVRQKEVEAFVLSMGDGLLLERMRVCKMLWDAGIKAEFLPKKKPKLQQQFAVVDKEQIPFAVLLAPGEWANGTVRVKQQIGKGEAGDDKGTEVPLTELASFIRSKLATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBT3</accession>
    <name>A8QBT3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728945.1">
        <property type="nucleotide sequence ID" value="XM_001728893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBT3"/>
    <dbReference type="GeneID" id="5853251"/>
    <dbReference type="KEGG" id="mgl:MGL_3939"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3939"/>
    <dbReference type="InParanoid" id="A8QBT3"/>
    <dbReference type="OrthoDB" id="3357566at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="493" mass="55257" checksum="76D833DAA113BE01" modified="2008-01-15" version="1">MLFRLFDQKTKEQQQRPKNEARKRWSFPLKRQSYANGPAERRVSMDQDLEQQEPPPPPLPVPKIVLQTATPASLSMHHVDSKQETQEPSISAHTLALDEAAQTVENDMPNPHTATPSAANGVHASSQDVGALENLPDTKEFSNSTASASVANEPILMFPSEELGSTGMAPNGTPAAQEDVRTLCALFQQHCQTLSYLRQVVLGEQQYVYSVKFSISDFQTNVPLQALNTWSANSAKVCKALEKTKQVTWPHEVLEILTDIVEEVSTSSGTDVTASTGQELNIVECLCSLLDSLSEVYAKLLLWLDRDSLMNLTGQSRVTPVVPSCELLDILEKNDRKLKKFIKCVAKDLSYVARCVCQHEVNEWDKILCDQNLDWENLSIRLQTLPEQQQHHALKKRAENVHTPNKEPSEHVVPSPSDVPTPDTEICEQRQVTSIKRRNVLSRIIRGKEPTRQSFLKDMNITARHPWNKRGEHSQLDRITITGPMLGRVSVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBZ5</accession>
    <name>A8QBZ5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NEDD8 carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728962.1">
        <property type="nucleotide sequence ID" value="XM_001728910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBZ5"/>
    <dbReference type="FunCoup" id="A8QBZ5">
        <property type="interactions" value="748"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBZ5"/>
    <dbReference type="GeneID" id="5853268"/>
    <dbReference type="KEGG" id="mgl:MGL_3956"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3956"/>
    <dbReference type="InParanoid" id="A8QBZ5"/>
    <dbReference type="OMA" id="CRETIYH"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000239">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="103" mass="11786" checksum="16E4B0B4AEDAF975" modified="2008-01-15" version="1">METQFPDPTNIKRFELLISPDEGMYRGGKFRFSISANDNYPHDPPKVKCLQRVYHPNLDLDGNVCLNILREEWNPILNLNSVVVGLLFLFLDPNADDPLNKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC13</accession>
    <name>A8QC13_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728968.1">
        <property type="nucleotide sequence ID" value="XM_001728916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC13"/>
    <dbReference type="FunCoup" id="A8QC13">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="GeneID" id="5853274"/>
    <dbReference type="KEGG" id="mgl:MGL_3962"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3962"/>
    <dbReference type="InParanoid" id="A8QC13"/>
    <dbReference type="OMA" id="DAQRNWD"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="259" mass="30147" checksum="7273FAB284194F92" modified="2008-01-15" version="1">MVEKTRRDAGRAWDKFYKAHEDRFFKNRNWTDREFDELREDTPNLVHGEEPVLLEVGCGVGNTVYPLLEKNAKLRVHCFDFSPRAIDIVQKNPCYDQHRVNAFIHDLLDGQSTQVLLHQLKQRPNWPPVSTLSIIFVLSAIPPQDQVRMLRSLITAIPLGATVVFRDYAHGDLAHLRFHTRKDAQWSEPSLLSDAHHWYRRGDHTMAYFFSRDEVERLFAEAGGVTGVVEEVVHTKVNRKTSTIMERRFIQAQFVRIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC69</accession>
    <name>A8QC69_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728810.1">
        <property type="nucleotide sequence ID" value="XM_001728758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC69"/>
    <dbReference type="FunCoup" id="A8QC69">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QC69"/>
    <dbReference type="GeneID" id="5853116"/>
    <dbReference type="KEGG" id="mgl:MGL_3977"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3977"/>
    <dbReference type="InParanoid" id="A8QC69"/>
    <dbReference type="OMA" id="ATILYCE"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="343" mass="37272" checksum="39E8DDFFE3B8D50A" modified="2008-01-15" version="1">MLSIALVDTLFLRLLGIAIASFASGLGEITYLQYSTRYVPQVTTYCVGWFASGTGAAGLVGASAWWIVRPLGVRLGLSLLAFLSFGTAISFFCVLPEPKKMPVSVPSEDESTEALMSLPDQESDHTRLVALSFSDKMKLLKPMLLPYILPLVLVYFAEYTINQGVAPTLLFTVPDPKQHRVLATLIHTLRDYYPLYQLVYQAFVFFSRSYTSVLPLPPIPQSWLWTPAVLQLGLLVLLSTESLFDWFKESIARSMVIVLIAVEGLAGGSSYVSVMSHIGGSDRSSVGPSGDSALSVQEYEFKIGSVGVGDSLGIVLASLVSIPLQVSLCQAQVARGRDLCTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCA3</accession>
    <name>A8QCA3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Purine-cytosine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728819.1">
        <property type="nucleotide sequence ID" value="XM_001728767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCA3"/>
    <dbReference type="FunCoup" id="A8QCA3">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="GeneID" id="5853125"/>
    <dbReference type="KEGG" id="mgl:MGL_3986"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3986"/>
    <dbReference type="InParanoid" id="A8QCA3"/>
    <dbReference type="OMA" id="ARWGWET"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="56785" checksum="915C588F65AAD870" modified="2008-01-15" version="1">MAPLDTSISNAGSVDKASALETKSIDADLGHDMERNSQSPRIYKRFRQVLSSPRWTGFAWLEWTNIEPIKPDEQQLKHPFSIALIWLSVNLNVLSFSTGMLAPQMGFGFRYFSYTTLGFLIAWGVFPACFSIFGHKLGLRQMVHCRYSFGYVGASIVALLATITGIGYTILNGILAGETLQAVSPHGSMSATVGIVIVTVLALLVSFCGIRVLNMIDCVFWLPVLISFAIMAGEAKSGPAGLHTDPNETRPTSQSVLALGCLHAGYYVTYASFSSDVSMYYHRDRSSWLLFVAVFVALIFSAPPIMMLGAAFATSADTVPAWREAIASNPSPGPIIHLVLSSHLGNFGKFLTVLIALSAMSNMMTTFYSMGLCIQTAFPPLMVLPRFVIPIFAMAIVLPIAIVGQNEFYTALTNFVSVIAYWACLFIGVVCADFVVIRRCRMSSYDLTIWDDWRKLPPGIAAITASVLSLGLIIPFMDQAWFTGPLGRHVGDLGFEVGLGLSFVLYCLLRPIEQWLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCA8</accession>
    <name>A8QCA8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3988</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728821.1">
        <property type="nucleotide sequence ID" value="XM_001728769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCA8"/>
    <dbReference type="FunCoup" id="A8QCA8">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCA8"/>
    <dbReference type="GeneID" id="5853127"/>
    <dbReference type="KEGG" id="mgl:MGL_3988"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3988"/>
    <dbReference type="InParanoid" id="A8QCA8"/>
    <dbReference type="OMA" id="GPIRTNS"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="46"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="395" mass="43933" checksum="99E7E00E5F6BDC40" modified="2008-01-15" version="1">MSATRELCTELEPSSKRIKTEDSKSESLMPSQSHALMPRFEHGLFLAPMVRTGSLPCRLLSLEYGASLVWGPEVVDRAIMETERDVDPTTGVVEFRKGDKPVFSTHPIERPYLIYQLGSATPEFAAEAVRIVTQHDDVAGVDLNCGCPKPFSTLGGMGSNLLSTPDLLCDIIKAMRRAAPPHVSVSCKIRLLPTQEETFSLVEKIVRARAIRVLTIHCRTKPMRPREAALLERFRAVAEHVAKIAKETEQDVTVVCNGDCFSVADIPHLRELTGASSFMMARGPEANMSCFQSQRECTATVLAPKWLRYAIRTNNLFGNSKYCITQMAFTTTAGAKDTDAEKISPLKKRDLVEIRSALSASQTHEDMARALHLPWPLDTSDVLEHLQRKLDERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCZ4</accession>
    <name>A8QCZ4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728727.1">
        <property type="nucleotide sequence ID" value="XM_001728675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCZ4"/>
    <dbReference type="STRING" id="425265.A8QCZ4"/>
    <dbReference type="GeneID" id="5853112"/>
    <dbReference type="KEGG" id="mgl:MGL_4062"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4062"/>
    <dbReference type="InParanoid" id="A8QCZ4"/>
    <dbReference type="OMA" id="WAVNGHI"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="238" mass="27089" checksum="E4011E676A21BABF" modified="2008-01-15" version="1">MYTYTQLVDDGNGLSDAYPELSPDDPKHKWAVNGHISNEVFAMADYDLLTIGNHELYNFSVARDVYEYFVPHWGDRYLTSNVNISLPEADGTLRSRPIGQRFTRFKTRNQQLDIQAYGVLFNFQLGAEGIQVQDPKDMVREPWFQESLRAFSHVDAFVIAGHMPVTGHDGWDALHAAIRDVWPTTPILMLAGHTHVRDCRMLDDYAMALESGRYLETIGWMSVSNVSFRATHILAALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCZ6</accession>
    <name>A8QCZ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_4064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728729.1">
        <property type="nucleotide sequence ID" value="XM_001728677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCZ6"/>
    <dbReference type="FunCoup" id="A8QCZ6">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCZ6"/>
    <dbReference type="GeneID" id="5853047"/>
    <dbReference type="KEGG" id="mgl:MGL_4064"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4064"/>
    <dbReference type="InParanoid" id="A8QCZ6"/>
    <dbReference type="OMA" id="VKQPIDM"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728082" description="Sodium/calcium exchanger membrane region domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="495"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="653" mass="70574" checksum="0A7A9B58D7E909BC" modified="2008-01-15" version="1">MFVLWLLVLFSVLGLVASDFFCPNLSSIAAKWGMSDSIVGVTLLALGNGFPDVVSTFRAMDKDAGTMAMGEIMGAAVFTVAIVCGSIMVFYSFDIPPVAFVRDVGTYMLAVILVLSFLRDGTLDLSDGISMLGLYVAYIGVVVMGDLLSERRTAPSTPTPAKTQDHSVSIQIPVEHTPLLRDRSESQIGSPSGPRVARHSILSAMRMHDMALHSDAGLLFTPSLAEHVIDPVSRAVWRQSTRTQRVASLSPSASFSNKHSPASPSGPVQDRRKLTRCFTYNSMECVPPTHTHPRTSKTFDQAPASRATASIMCKIMALQDCHNNHLSFSRIVFVALCPSLVNFTHKSWGNRVASVACAPALFVLRLSVPLISPDEYRLHDSLRMLRQTLSDEPADGAARAVELREAVWDEAVAVLETPGPLVKTSERVAADHFLSSIQCVAVPEMMLWSYGASPALLASVGVCGGIVGVFVWRKLRASPDRDSPAQLQRFLVVRSLLGFFMGLLWIVASVDGVLALLRAWGYIYHWSEAILGLTVFALGNSLGDVVTNLSIAQLGHPLMALTACFASPLTNLLLGVGLSTTWLTSTHPSRAPYRIALSPALFLSSAVMVCMLLVMLITVSMNAFSSSRPLGLFLLITYVGVMTCNLVLEIKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD12</accession>
    <name>A8QD12_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728745.1">
        <property type="nucleotide sequence ID" value="XM_001728693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD12"/>
    <dbReference type="STRING" id="425265.A8QD12"/>
    <dbReference type="GeneID" id="5853091"/>
    <dbReference type="KEGG" id="mgl:MGL_4080"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4080"/>
    <dbReference type="InParanoid" id="A8QD12"/>
    <dbReference type="OMA" id="GHVMFRT"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="155"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="431" mass="50240" checksum="58265FEF8B1930B5" modified="2008-01-15" version="1">MEESDFIRDTYDYFLHKGISNDGLADGVEYTRQKQIVPPWENEVADTTQREETPVDRYGFFDTPDKRNLPTIVLSRAAYVHRRFFVRARKTRAPKKRMHQPSAQAVWSVRRHLESLNEVLELRRTRKWYSMVDEEQRRIRVDVSRDLLLKRVYKGIPDEMRGLAWDALSSSQAYGHSQQGTRHRHTPQPVDELLSHASEHDVQIDLDVPRTVRGHERFYTRYGRGQCELFCVLHAMSLFCNECGYCQGMGPSAAMLLMHMPAQHALKVMERLHDEYGFHDVYRPGFPGLRSEFYVLRQLLATFVPRFARILYDAGLAPSAYATRWLMTVYHGVLPYSTQMRVWDVFMAQGRDALLLVAVAILRVLDAQRYDEHTSDILDFVSMQILPEDDNAMLTWIRHAMKDPAVQSCIAKSRADWKRLVELGKDVEEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD29</accession>
    <name>A8QD29_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_4097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728762.1">
        <property type="nucleotide sequence ID" value="XM_001728710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD29"/>
    <dbReference type="FunCoup" id="A8QD29">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD29"/>
    <dbReference type="GeneID" id="5853031"/>
    <dbReference type="KEGG" id="mgl:MGL_4097"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4097"/>
    <dbReference type="InParanoid" id="A8QD29"/>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="267" mass="29749" checksum="0530A8E2AF8C4BCE" modified="2008-01-15" version="1">MEVSRGVPIATWSCGQCARTVPNPYAKTPHPTVLDHHRPSSTIPTLEGMAGWFSWVSGKRDNKNTARDAIIGLREQLHLIAKKEEHLQTKIDEELRKAKDNVTSNKRAAQAALRQKKMYETELDRLAGSRMTLETQVNAIENANMNLETMRAMQRGSAALKHIHANMDIDKVDNTMDSIREEMALTNEISEAISNPVGLGHELDEDELRNELQELEQDELHNRLVGAEAAPAHHISTPTQSDATKNAHADSVDEDAELRALQAELAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD65</accession>
    <name>A8QD65_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_4133</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728798.1">
        <property type="nucleotide sequence ID" value="XM_001728746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD65"/>
    <dbReference type="STRING" id="425265.A8QD65"/>
    <dbReference type="MEROPS" id="M67.A09"/>
    <dbReference type="GeneID" id="5853038"/>
    <dbReference type="KEGG" id="mgl:MGL_4133"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4133"/>
    <dbReference type="InParanoid" id="A8QD65"/>
    <dbReference type="OMA" id="QYLCLAK"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="664"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="851" mass="92166" checksum="BDE248FD65B34439" modified="2008-01-15" version="1">MKLRRFRAQEASAVPCSAPGTLAEQRMLTSPMNQVSLLARTDTQQPQTQPGAGFFSRTNRRPASLQELDEQVADLRQELRFSSSVPISHWIRCADVLKRRADQHHHASDLEGQYLCLAKCEKILAELIPHEHTAWHKLDSKNAVAIHSLVSLTRDALLDARGEARSSASSASSAQYKPPLSPSALAGTPSRSSFRRNSSTRKRVSFAEESVSSPSMNRTTPRSGWSLRSILPWHRPSLSATSSSDKPAPAVVTTLSSRPAGLPLSTPDAWASSAAEPAVPATSTSASGYVAADPKRFSRPHASHVKHTAQARASASTARPPTQPDTRPASYAALHPAPMPTYPPSVEAGPSRAAAPPPVDGRPRQDPRRSMSPTDAAVGRRGTTYSTTAQHKPTPVPATVTRRASRTASRAVSPPLSVSPSPPTLSPSTSRASSPTGFARRSTYLSTSIPSIPQAPIPTSSPPRTSSSAAPIASLSRSPPSVRRRSSERRFLTSDRPASLVVRPSTSLLGMPASSRAPAGKERLASVADTEQEYERRTPARTSTEAVRHRDQDRDYDRDRDRDRDREVHARARAHMPLQRRASKPHGPRPSSVDIRTNLAGWARLPEVQSSPPLTSLDLFMLPSEELGEVAAQSRTSAASGATAATDGKQARCPTTEAGDVLRQVVLPGTLPTRFLAHAQANTKAERETCGYLLGHRRFDALCVTHLVIPEQTGTNYSCQAYGEEQLLAYQIQHDLLTIGWIHTHPTQTCFLSSLDLHTHSGYQALLPEAVAVVCAPREQPSVGVFRLTQPPGLQYILQCKDPEPFHAHADQDATSTPLYTDATHGHVVWKEQAPLTIEDWRSSHPACPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD76</accession>
    <name>A8QD76_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="13" type="ORF">MGL_4144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728665.1">
        <property type="nucleotide sequence ID" value="XM_001728613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD76"/>
    <dbReference type="FunCoup" id="A8QD76">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD76"/>
    <dbReference type="GeneID" id="5852989"/>
    <dbReference type="KEGG" id="mgl:MGL_4144"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4144"/>
    <dbReference type="InParanoid" id="A8QD76"/>
    <dbReference type="OMA" id="VWHITLA"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728086" description="UDP-N-acetylglucosamine transferase subunit ALG14" evidence="12">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="175" mass="19298" checksum="D562AAEA3890133C" modified="2008-01-15" version="1">MWVCLILCSLCMSAIIGLGCIGRIHQVRRRAPPKRPQRQLCIAALLGSGGHTAELLTILRALPQDQYTPRIYFTTTGDALSLKKAADAEGGSLARHEMQGLCIPRARVVKQSWLTTPLSVANSTAFCVWHLGLAPIFRRRDKSREEHVPWADVLIMNGPATCVPVVIAIIFMRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDA1</accession>
    <name>A8QDA1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728689.1">
        <property type="nucleotide sequence ID" value="XM_001728637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDA1"/>
    <dbReference type="GeneID" id="5852982"/>
    <dbReference type="KEGG" id="mgl:MGL_4168"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4168"/>
    <dbReference type="InParanoid" id="A8QDA1"/>
    <dbReference type="OMA" id="DMWESED"/>
    <dbReference type="OrthoDB" id="3366950at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="78554" checksum="D1875018B57C3D83" modified="2008-01-15" version="1">MASALKGVIDESSAAAEPVKQARFILARIQQLNVLREKPRSTWDLGALNAEDHHALIRAANDAEGVAVVDGQVAKLKERITELKFQFGEQMKHAFQASMQSMFPSTDNVAASSGRINEERQVLNEEGLPFVDPLESLPDSPPQTPRWDTEQPPPPTGNVLGRVPGHIVPFDPSLQGDERKKWMNSVMDQLEEEERAEQAKLDEQQQQRQETNRSALKLRRGFLQSDAHRPKKHVRIAAPSDDSDESEPVSKAKKVPPGMDPEDVGVQEEAARIVELLGPEVIQGHPNAERIFAEMEASHPKVIQKPAPAPSSDASKPAIGETVLERSAEAETKRTPSVGAKRKPSAFKQRQQLQKQAQEQIPTAPTVSQGISAIERAGRVEDELGQERSKQGLPPRVPHARPTKAYAAKLAQRAVQASEQKDDIDDEIVEKPGRRVRFGGEEVLNNDESEQPMDQDEEEEEDHHDESDELDLDDDYDADMWESEDESLWDSDDQYGAEDLEALKPTMQGHPGDEYWTEELAREYAEAKARLSLHPRMPQSAHDDHGDAQESYGIAPLSASVSDSHSHPSSQERPRVSRFKAARMMGESVPDPNGHYHYPSAEVPAAEVAGHELTHTLHESNVSQNSHGSQPIMVLPSLAPVRFPRPVSDQREGSGLGFDLDGESDEDDERLHALMRARLSMHDEEENGLGSTQPPPRASQRPPHVGHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDA8</accession>
    <name>A8QDA8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_4173</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728694.1">
        <property type="nucleotide sequence ID" value="XM_001728642.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8QDA8">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDA8"/>
    <dbReference type="GeneID" id="5853004"/>
    <dbReference type="KEGG" id="mgl:MGL_4173"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4173"/>
    <dbReference type="InParanoid" id="A8QDA8"/>
    <dbReference type="OMA" id="MTKMNVG"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="2"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="419"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="730"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1222"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="116"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1118"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1118"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP41480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1409" mass="158950" checksum="BDA2CF0C16F604B6" modified="2008-01-15" version="1">MMEDDFIEDDDGSGYVDHGQDEWANERASESESESEHEYYERTGRKKPRKKSSRRANRSVQTDYLGSSRRSAPVPSHTKETEEAFMSNLFGGLDQLSTPSRPMTTLVLDDAHDSPSLAMARKRKQLHTPTTLPALVPDMSSSTEPSSDTLDDSWHDIHTQGGPKKLKSETNDQRSPPPSPPRPSPPRNAPSHSLSTPESMDEDDFGVISVGAKREVPVAQDDAIKTTKIPPARPHKPHDAPEEPTSHLQTWRSVHDGLVTESTESPASQVASSTYSGVAKKVECFQDDRSVHFFWIDYFDANGKIFLFGKVLDRATNKYVSASVAIDGMERCVFLLPRTRTIVDGHETDMVPGEDDVFEEFETMRSRYGIKSWLGKWVRRKYAFELPDVPAEGPYLKVKYGFDEPALPADISGATFSRAFGTHTSAFELLVLKRRIMGPCWLRIEQASLPSGPPRTWTKLELEVDDPKSVSPFSDTDANAPKEPPPLTIMSLALRTVVNYKENKREIVAVSARVWRDMALENPTPPEQLPSSSFTAVRPLGASFPPRFEEQAAQGKNKIKAFKFERMVLNSLLGQIQWHDADVILSHDFVGSTMDTLLHRMRDLKCENWTRLGRMRQDVSKMVKQSLHALHTRMLVGRLVADLSSDTAKGMIPSTTWSLSEMCRTHLNAQREDIDPEDVASFFDCTAPTPERLLTFVRHCEVDAFFQMAMACKMQLLALTKQLTNLAGNAWSRTLNGGRAERNEYILLHEFHKKKYICPDKQSMWDKKAAKKEEGSAKKEKFKGGLVFEPKRGLWDKYILVMDFNSLYPSIIQEYNIDFTTVERHADQDGDDVPDVPSSDVAQGVLPHLIATLVNRRRQVKALMKDKHAPALKQLQWNIKQQALKLTANSMYGCLGYENSRFYARPLAALTTFKGREILSTTRELAESMSLDVIYGDTDSVMINTRCIDYQAAIKIGHEFRRAVNERYRLLEIDIDGVFQRMLLLQKKKYAALLVNETGATQTEIKGLDMKRREYCALSKRASAYVLEQILSGEATETVVEKMHEYLQQLATDVREGRIPLDDYVIYKRLGKRPQDYPDAQNQPHVQVALRMLAKNETARSGDVIPYVFCVGPQTPSSNDSINNSNHNSNNHHHHQHTKATQAERAFHPDDVRRHMDDPAYAIDYKHYLSLQILPPIERLADSMEGTDRSRLAACLGLDVHTYTSSSHASSDSSREWMTLESQVPSSIRYAHCDPLRVRCRQCGAVSDAVPLAHSARTSEGAAPWLSCPSCSTAWTLPSLVVQLQLAIRAHIARYYEGVQTCTEPSCRASSTMTGVYSGRCVVPGCRGKVLAQYPDKALYTQLCYYAYLFDSTQAMAETSEAAQHLRLRDTIDARRADLDVLYATVQQYLARNARRFVGLDKLFSFMRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDB1</accession>
    <name>A8QDB1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_4175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728696.1">
        <property type="nucleotide sequence ID" value="XM_001728644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDB1"/>
    <dbReference type="FunCoup" id="A8QDB1">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDB1"/>
    <dbReference type="GeneID" id="5853019"/>
    <dbReference type="KEGG" id="mgl:MGL_4175"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4175"/>
    <dbReference type="InParanoid" id="A8QDB1"/>
    <dbReference type="OMA" id="WTHISEQ"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="43"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="300" mass="33235" checksum="2F24968A78B73F4F" modified="2008-01-15" version="1">MDAAHITGLLEAIESNGLLRQNRVLTGYTPSPEALCAVESFIRKLREQKPDMIYLLDPVMGDMDRGMYVNADVLPVYRRMLPLSTIICPNQYEAQVLADENITCLDSLYRVLEKLHTVYKVPHVVITSLDLPPADLAKLGVEPTMSDGKPTMLLVGSSWTGHLSPWFLTFPSQGEYFSGVGDLFAALVLARFAEHAHELPEAARTPLSDIPPSSKEECALPISHAVMLAVASLQHVLTRTRATMEAEGARLGLDPFAPAHKASVEDRVQIMRMRELKIIQSAPAILQPQVQYRPRWMPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDH2</accession>
    <name>A8QDH2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_4205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000022">
        <property type="protein sequence ID" value="EDP41430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728644.1">
        <property type="nucleotide sequence ID" value="XM_001728592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDH2"/>
    <dbReference type="FunCoup" id="A8QDH2">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDH2"/>
    <dbReference type="GeneID" id="5852958"/>
    <dbReference type="KEGG" id="mgl:MGL_4205"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4205"/>
    <dbReference type="InParanoid" id="A8QDH2"/>
    <dbReference type="OMA" id="DNINIMM"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="430"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="502" mass="55185" checksum="E96B63E719A0A8D9" modified="2008-01-15" version="1">MAMAPINAFDSSRSSLSSSFNGENNGPWISSQSSAHLSRSESMPAFHATVDKIQEDHFEAAKSIVLKDDLLRTELERGITEDCYRLREFLQAARILNEVSPRSRDLIMGIGERLACRLVVAALEERGIRAELVTLETIVDELDEEVLRPASTSYESSNYLEQSFYDRLSTALANRIMQCEGVPVVTGYFGNVPGSLLSQVGRGYTDLCAALCAVGLKADELQIWKEVDGVFTADPRKVPTARLVPAITPEEAAELTYYGSEVIHPFTMEQAIKKSVPIRIKNVENPTGCGTVIFPDHISPSVDDDIKHDPFVDGHVEQPEPPLNGLSTPMHSRQQQKEPRKTPTAVTIKDNIIVLNVHSNRKTISHGFFAGIFGTLNRYGVVVDLISTSEVHVSMAMTADIKARTLERLSAELEHIGTVSILRNMVILSLVGKEMRQMVGVAGRMFSTLAEGNVNIEMISQGANEINISCVIHEGSALKVRISNNSLPLTHKGVEPHSLFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8QEC3</accession>
    <name>A8QEC3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_4264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000032">
        <property type="protein sequence ID" value="EDP41385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728599.1">
        <property type="nucleotide sequence ID" value="XM_001728547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QEC3"/>
    <dbReference type="GeneID" id="5852907"/>
    <dbReference type="KEGG" id="mgl:MGL_4264"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4264"/>
    <dbReference type="InParanoid" id="A8QEC3"/>
    <dbReference type="OMA" id="CCCTIFA"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="44"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="434" mass="47579" checksum="D48FA03965D4D03A" modified="2008-01-15" version="1">MMPSQRDIAQDQIYTAEPFEDPTPIPVVPLTTETQENRLKNWVSFLQVASAFTFLFCSWGLIGCYGTFFVYFKDHLVPANSASELSWIGSVQTFLAMIVGILTCPLVDKGNMFSMCTAGSIIIVLGVMMDAQSTNYVQVFFSHGICIGLGSGLIYLPCVTCCSEYFSTRRGTALGVATLGSSIGGLIWPVVFNNLQPSIGYVWTMRTIGFMILGLLFFALSCFRPRKEAIEPRRMIAMNVFKDPPFLIFILAYLLCMFGLYVPNFFLPSFGKHSNFSSSIFPYTTCLSKSGGIAGRLLSILLTQRIGAFNLFIPRTIIAAALIFVWVSISQQGSFVTLVILYGFFTGSLLSSVPMLVSMLTEEASEINLRLCMASFISSFGVLLGPPIAGSLLQVEPPKYLHAQLFAGVMLTGSGLCLALARAMKVGLHPIKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8QEM3</accession>
    <name>A8QEM3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_4273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000036">
        <property type="protein sequence ID" value="EDP41375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728589.1">
        <property type="nucleotide sequence ID" value="XM_001728537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QEM3"/>
    <dbReference type="GeneID" id="5852897"/>
    <dbReference type="KEGG" id="mgl:MGL_4273"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4273"/>
    <dbReference type="InParanoid" id="A8QEM3"/>
    <dbReference type="OrthoDB" id="4009151at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047741">
        <property type="entry name" value="DIP1984-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038048">
        <property type="entry name" value="DIP1984_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20935">
        <property type="entry name" value="DUF6847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="69" mass="8225" checksum="B8D7F3FDA0F02CD9" modified="2008-01-15" version="1">MALKRRKLYSDVATKASTAQDRYTRSEIKYVSVIDVRKMQKQVDKLAGEYRTLDTRIQKMNWEVELIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQX5</accession>
    <name>A8PQX5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0531</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732756.1">
        <property type="nucleotide sequence ID" value="XM_001732704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQX5"/>
    <dbReference type="FunCoup" id="A8PQX5">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQX5"/>
    <dbReference type="GeneID" id="5857062"/>
    <dbReference type="KEGG" id="mgl:MGL_0531"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0531"/>
    <dbReference type="InParanoid" id="A8PQX5"/>
    <dbReference type="OMA" id="WFEESSN"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP45542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="452" mass="50153" checksum="A2BD73838F4B2342" modified="2008-01-15" version="1">MDADARASAEAAEKQWDDTSAPSVDMSELGGPFEGPEKLLELWFAPNVDALPECQRAMAERGVRLGGRLGLRRVPKSTWEGMLDLVKCKILSVETSAEVDAYLLSESSMFVYPHKLILKTCGTTTLLFGLDRLLRIAKATLFDEEALSLQASSVSSTMIANAVAGDADCKILGGCVRHCFYSRKSFMFPEKQQGPHRDWMLETRFLDQYFDHGAAYTVGKMNGNHWLLYMAQGVDMEAETEAKKEAELELQSTSAPAIARRSLPDTDLTLEILMTELSPKACEPFFFDAKDSTNIESAHKLGRDVSAKLGLSSLFADTQLDAFAFEPCGYSANALVSATPHHSAGYWTVHVTPEEASSYASFETNVHLDCDGAIQDAHTHVTNVPELVSRVVDIFRPGNFTLTLFISMDHADSAAQLRSLELPHYTKSDRILYEFEGYELLFLSFHRRMTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQZ7</accession>
    <name>A8PQZ7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mog1p/PsbP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732778.1">
        <property type="nucleotide sequence ID" value="XM_001732726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQZ7"/>
    <dbReference type="FunCoup" id="A8PQZ7">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQZ7"/>
    <dbReference type="GeneID" id="5857084"/>
    <dbReference type="KEGG" id="mgl:MGL_0553"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0553"/>
    <dbReference type="InParanoid" id="A8PQZ7"/>
    <dbReference type="OMA" id="ECSSAWM"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="18997" checksum="DD45E8AE8E32BE24" modified="2008-01-15" version="1">MPHYQLFGGAISIHLDGNYMDASDLRQVPDNQEVLLSRDSDVSVIVEVLQCVGTSTDADAMDHGVRYHFDSLAHDNSALESQILKVASTTCIPQNPAQGATPTPSLAQGLQIVRKFGKASDEDRVQISIAMWRLPSKNVDLVLSINDPTCARIDWSVLQQAASSLHIVDWGLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRJ2</accession>
    <name>A8PRJ2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0065</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732290.1">
        <property type="nucleotide sequence ID" value="XM_001732238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRJ2"/>
    <dbReference type="STRING" id="425265.A8PRJ2"/>
    <dbReference type="GeneID" id="5856596"/>
    <dbReference type="KEGG" id="mgl:MGL_0065"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0065"/>
    <dbReference type="InParanoid" id="A8PRJ2"/>
    <dbReference type="OMA" id="IEPNGDW"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="152"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="339"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="446"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="58870" checksum="104DE7F9A3A50DBC" modified="2008-01-15" version="1">MELGAVSILSDYVKSLKVADLKEHIKAFNERLPFCPHMRLSGNKTELAQRLTEAVLASCMNPQYFQEMLCVIAPLGYTCWSSDQDRLRRAANQYTSFYGRSPANGEAPPSLSILGVPASGSFESFTASSNARVNAGSASSTNSASTSTAPKSLTPNSLKQLRFWPSPFYEVQEFVSSIVQVPEAPPASGRRQVGVSFTLSEKQVDRLLDTQHLHQLRLFCTTFDQFMASVSPKREAAPVEFPYTCDARINEHSLNVNLRGNKKHAGRVSPPNLNRNGHLSLQPGKLNRVELSYANAPSRYTMVIALCKITTAEQLTEQLKHRRYRSKEAVIDMMHKKSRDEDIETGASTLKLTCPLTYVRMAVPCRSNTCDHIQCFDASSFFSMNEQSPQWQCPVCSQDIKPEDLRMDGYVEDILRRVPPDLDAVLVESDGSWHSPDDQYHSGSAYITSLPPSIPMDQDTLLDHTPSPERTPQRSLPSNQLEPTKQEVATPPCISFPADLNTSGTSLVHPTEHSEPSADVIDLTLSSDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRK3</accession>
    <name>A8PRK3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732297.1">
        <property type="nucleotide sequence ID" value="XM_001732245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRK3"/>
    <dbReference type="STRING" id="425265.A8PRK3"/>
    <dbReference type="GeneID" id="5856603"/>
    <dbReference type="KEGG" id="mgl:MGL_0072"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0072"/>
    <dbReference type="InParanoid" id="A8PRK3"/>
    <dbReference type="OMA" id="HKKYLVH"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17914" checksum="93828E5649E14191" modified="2008-01-15" version="1">MGATTLTGIVTKAGFMAKTVTMTVAKVKTHPKLHKTYVRHNKYLVHDPESSLSIGELIRAQACRPLSARKRFVVTERLGFQHGASTDATTQADAERLRRERTEASMPAAQREWLDIEQRVRDESLLIEDTKALLKKYPTFYKNEHWLATCNVACVFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRU5</accession>
    <name>A8PRU5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732355.1">
        <property type="nucleotide sequence ID" value="XM_001732303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRU5"/>
    <dbReference type="FunCoup" id="A8PRU5">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRU5"/>
    <dbReference type="GeneID" id="5856661"/>
    <dbReference type="KEGG" id="mgl:MGL_0130"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0130"/>
    <dbReference type="InParanoid" id="A8PRU5"/>
    <dbReference type="OMA" id="THYIPNI"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="13"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="413"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="498" mass="56220" checksum="9F5A51A6DF9153DB" modified="2008-01-15" version="1">MHVGDFEGAMQQFCHTIGVISPSMVIRKFLDAQRLQFLTVYLEALHARHLANADHATLLLNCYTKLRDTDALDRFLRAPDVPLDVQVAMDVCRRAGCTEQAAYLAQTHEIHDIYLNIQLRDKLDPKAALAYLETLAPSDVMDYFPPCARLLLEAEPEATADLLVRVYADSSDSKVTLLPSMLSHFVGHERTLERFLERIRTAKRDRHELVLVHDTLIELYLKHAPDKALAILESHDDVTPYTPSSALVLCQDASYTPGLLCLYERLGMVDAIYEHWVHAHEAGDAEAPRQLLQMLEKFGTSETHLYVSTLAFFTSSSDLLEAHITDVERMLAYIETHALLSPSEVVQLLGRNSVAPMSLLTPYLMKHVHNERTELLSAQKLVASYREEAQTKQAEIAALQSLDEPRVFQHHECGLCNQPLELPAVHFMCRHSFHFRCLPEGEAARECPICADEHKTVRALRDPSMLSSLDMVLEEVHAAEDGFDVIADMFSKELTLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRY1</accession>
    <name>A8PRY1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732378.1">
        <property type="nucleotide sequence ID" value="XM_001732326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRY1"/>
    <dbReference type="STRING" id="425265.A8PRY1"/>
    <dbReference type="GeneID" id="5856684"/>
    <dbReference type="KEGG" id="mgl:MGL_0153"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0153"/>
    <dbReference type="InParanoid" id="A8PRY1"/>
    <dbReference type="OMA" id="YVGCTFI"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="446"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="880" mass="96907" checksum="EA1BB467E7718F55" modified="2008-01-15" version="1">MEELLRSLRNLELAEPHGEQIVALVDPDPRVEKQLAQQLAVPARIELHEDDASALMDAALMSGATEAMLDNYNAALKKESDMLQKEFENRKKPSRVKPVPLKALLAAQEAAIRRRHAEREAGSTHDGHVYVPRQIMDTEHTYASEKPVSALSRMDMDELMAPKRYEHKYLLVQVASRLALYASCCFVGVTPQGGAIPVSIAHFTPNLHLYGDELDALLPIGSVLLIREPYVSQHYMGVGGPVTGGKGMVGVRVDTPADVHVLDARDPILQGVEWKHKVPVMEEHAVSNVVWRQEGPLTRAWQLHIEPIDMSRESVHATVRTLLQQERPGAAWREICAAELFGIWSAARKTRRRENSRCPALVHDTLLKAEVLFSLQLYDRVCECLDKCAGMSLSESEQAAVTDRRSAAQLALEVGRKGPSDTQLYDMFLRTLQDPTPRYDYAEYVGPVCVADIPGAGRGLVLTRDVEEGELLLFCRAMGSSYAKDAACLGMPLLRCNPDTGVTSTTTQVLAATRCMHAMMDRPELALPFLGLTAGPDTPYSHYVLEPYPLQTRAMYEVKDALHMVSPLSSATPLCVSSHYVNNVLRFNAFGPAAVPAAEAGNDPMSRSTMPHPLPAILNHACLPNVSSVFFGDFVTTRALHPLPKGTQIMHQYVQGEVPYDARQAQLAKHGFVCTCGLCELDAADGAERRKRRDEILARDWPPLQDRSRALLKGDTHGHAAAAEAHKDMAESLISVADALAQTYAPTRGKLQPDMVDVWHRAAMHVRVYDRQQAMDLAHLSLAATGAVPCADGPHQRISHLPQLHLDGAVRSMLMLAGLHWDTDAPDSRQQALGWLESAVHSHTCMIGGGRALFLQRWGGDRAEGEYEKPLHAWLSTNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS04</accession>
    <name>A8PS04_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0167</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732392.1">
        <property type="nucleotide sequence ID" value="XM_001732340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS04"/>
    <dbReference type="GeneID" id="5856698"/>
    <dbReference type="KEGG" id="mgl:MGL_0167"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0167"/>
    <dbReference type="InParanoid" id="A8PS04"/>
    <dbReference type="OMA" id="CKERTTT"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902903">
        <property type="term" value="P:regulation of supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF60">
        <property type="entry name" value="CLASP N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLASP N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="7">
        <location>
            <begin position="73"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="374" mass="41188" checksum="85990711D881EE18" modified="2008-01-15" version="1">MRGKLLSERTRLSGTASDLLNSMAPRLAERFSPFVSVFIPPLLQLCGRTNKVALRRAEKSLHLICRHCRLPNVVPYLIQSLMDKSGSTRASAAECLVVLLESCDPERLQRRVKDVEHAIQLLATDANPQARALCRQIYGLYAGMWPARCASFFPTLSPTARRYLAAVQPVERLYTHDDVQHQEDTPSPIATHPMITRVSRIEPRQKTRSPTLVSKTQSTSNTLQSLTIPRTPPTPLASSADPFERTGVPPVPPRGSNPSDGVAYRLALAREQAKLRATQRLGATSTDTPGTRLASRALARSSASIGSARRVVVGRSEPTTPTTPQPYTVDKKNTSPFTASSQFTPKRRPFSVVNQDRSPQARMGLRTTHANIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS24</accession>
    <name>A8PS24_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732404.1">
        <property type="nucleotide sequence ID" value="XM_001732352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS24"/>
    <dbReference type="FunCoup" id="A8PS24">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="5856710"/>
    <dbReference type="KEGG" id="mgl:MGL_0179"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0179"/>
    <dbReference type="InParanoid" id="A8PS24"/>
    <dbReference type="OMA" id="APFNAGM"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF1">
        <property type="entry name" value="UPF0590 PROTEIN C594.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="1">
        <location>
            <begin position="345"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="498" mass="56127" checksum="528D70041B878C6E" modified="2008-01-15" version="1">MPRLEVKVGPDRFNMEPCRLNDTKHPHEIDTEHFCGRVLVRVLDAPGARVGEPGREYFQDRTRRFCIQIEGRFKKYWTGDDILFGSDFDMFVPFPRAPFNAGMRVARMIDPCTFYEEHPPSGRPYIMSPYAACMNTFCAWPSPDRLGDAVVVSNDHGDIPSYAADHGNDGDIVPVERIDYSHSHDAEKKSSSRWFPSILGSHKDERVTNSYWRFLGLSDDPAVQAYIRQHPPSRPGSADIRVQRSNTTIPIAPAAAMAVPTPVVAPVPSLAPAPSLQRPIPIMANPMPRRLQQGIDTHTMTALGSSKKPNVVLTRLHLDRPDTPDLPVFLSSNLSLSSTDTFGSPGMTQSPVQQSPIPMRPGTAQMLERRYMTPSPASSLHQNSSLNEKLGPWRFSDPSSDMVEDNAFIFKTESVSVPKRRKYFSDEAHRKSFVYHPDIVYGASFFTNLFDFNTFDLNIGPVHINVHPFFQQMPIRYTLRSKTNEELVFCTISFQLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS47</accession>
    <name>A8PS47_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732417.1">
        <property type="nucleotide sequence ID" value="XM_001732365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS47"/>
    <dbReference type="GeneID" id="5856723"/>
    <dbReference type="KEGG" id="mgl:MGL_0192"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0192"/>
    <dbReference type="InParanoid" id="A8PS47"/>
    <dbReference type="OMA" id="HITVGPY"/>
    <dbReference type="OrthoDB" id="3339751at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="74" mass="7977" checksum="95EB4B7E0AF10EA3" modified="2008-01-15" version="1">MSSKEVSKSPDLTRDQPAVVAPELADENGAPVPEIGQDAQTGPEIVGEEVPNRDSVKKKKTLFQKLGSLFKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSA3</accession>
    <name>A8PSA3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor IIIC subunit 5 HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732446.1">
        <property type="nucleotide sequence ID" value="XM_001732394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSA3"/>
    <dbReference type="FunCoup" id="A8PSA3">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSA3"/>
    <dbReference type="GeneID" id="5856752"/>
    <dbReference type="KEGG" id="mgl:MGL_0221"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0221"/>
    <dbReference type="InParanoid" id="A8PSA3"/>
    <dbReference type="OMA" id="KLKXLQK"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="2">
        <location>
            <begin position="46"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="390" mass="43528" checksum="E616D21CAD16B7A9" modified="2008-01-15" version="1">MALHRALMQLDVDAMRTYRYPPESETYEVPETTKDGSTRMRSNLAMLPPPFFSRQELPFPFGYRQNPTSSLQTLSHATTSKRSRRTARKGEADTEPKHGDDRGQTTITRYINRARWRNLAPIAIKFSDPAPVPTMPDASLATMPLSEKQKAQLAMLQEQWQKRPIWSRLALLNQFSEADARAIMQVKELFALVAYTFADGPWRDALVRFGYDPRTDRQSRFYQRIHMRGKAPRAPTTRGSLKAEYGDTATSARSSRGGGNVGFSSKRPPTHVFHGKTTTLHTSTFQLCDITVLSIVPLIHADGPSNLLLSPDISTGWYTPQAWEAIRTKISSTFHALLNAADADSGAVSSTQLEEHENEPTSDGASDDDNYSSSSDDDDDDVNDVVDVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSA6</accession>
    <name>A8PSA6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0223</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732448.1">
        <property type="nucleotide sequence ID" value="XM_001732396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSA6"/>
    <dbReference type="FunCoup" id="A8PSA6">
        <property type="interactions" value="715"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSA6"/>
    <dbReference type="GeneID" id="5856754"/>
    <dbReference type="KEGG" id="mgl:MGL_0223"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0223"/>
    <dbReference type="InParanoid" id="A8PSA6"/>
    <dbReference type="OMA" id="NRMMVLA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727068" description="Nucleolar protein 58" evidence="10">
        <location>
            <begin position="21"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Nop" evidence="11">
        <location>
            <begin position="299"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="547" mass="59785" checksum="2364BC2B77CED086" modified="2008-01-15" version="1">MVLVLFETAVGFCLFSLSDEAKVNSPNLYKHFENETEANRLLQLSAIHRFQSTVEAVEGVTATNEGKLSKGLKQFLTSEILEKGGSTGAKGASAEKLIVSEPKLASAINKKLGIQVTSESSLMDLYRGIRENLASLLSSGSPEAGALDPRDLNTMSLGLSHSLSRYKLKFSPDKVDTMVVQAIALLDDLDKELNIYAMRVKEWYGWHFPEMGKIITDNIAYAKVVRAVGFRTNASSCDLSEILPEEVEQTLKAAAEISMGTEVSDSDMEHIWSLCEQVVSISEYRAQLYSYLCNRMAAIAPNLTALVGELVGARLISHAGSIMNLAKQPASTIQILGAEKALFRALKTKHDTPKYGLLYHSSLVGMAPPKMKGKMARMVATKAALSTRLDALADADSKSDLSAPTIGSESRAKLEARARGLDYVQTMAGIRANRGADAGSKQKSFSMEAGGRGYNVGADAPPVVTGVADDDDDEEEKEEEEQGEEDDEPKEKSKKDKKDKKEKKKEKEEKKEKKEKKAKKEEKKSKRPASDADDSTEARKKKKKSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSD0</accession>
    <name>A8PSD0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="5">1.2.1.31</ecNumber>
            <ecNumber evidence="4">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_0235</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="5"/>
    <dbReference type="EC" id="1.2.1.95" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732460.1">
        <property type="nucleotide sequence ID" value="XM_001732408.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PSD0">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSD0"/>
    <dbReference type="GeneID" id="5856766"/>
    <dbReference type="KEGG" id="mgl:MGL_0235"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0235"/>
    <dbReference type="InParanoid" id="A8PSD0"/>
    <dbReference type="OMA" id="FHEVACA"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="17">
        <location>
            <begin position="931"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP45246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1026" mass="112661" checksum="1EF08C927616C1D2" modified="2008-01-15" version="1">MTHPPASGTSSEKNLDYWSQQLRNLPRLALPLDYPRPATTRVVHALKSCVLPPATCRALARLSLYEDENEVPSRFSETMEEEEQPRACHFLLAALVVLIHRYTGDTDIVVASNHPDTGEALILRIRVEPGDAFLQVAKCVQAVEAEAIRHLAPYDDIARRLESDRVATEGPAPSGTSHAPFRVRFFDETASMQWFMQRTNATTDLSMFVTPPEASVDAEVGPAHTTAAQSSVKPSRDGVSAFRAPAHAPVAVHISYNALLFSAHRIESILSQFDQLICSAAKHPMTPVGQILIRTKAESHMLPDPRKDLDWCGYRGSITSYLERHAQTFPERRCLVESVMSAAPDGKLPAPASQVRTVSYGELDRASNVVAHHLLHSGVQRGEVVTVYAHRGVDLVVAVLGVLKAGATFSVIDPTYPSSRQNIYLQVAKPRALIVLAKAGSIHQQVRACIQEELELRTEIPALELGADGVLRGGNVGAGDVLKEAQAFAGQPTRVVLGPDSIATLSFTSGSTGIPKGVQXRHYSLTHFFPWMGERFELGENDRFTMLSGIAHDPIQRDIFTPIFFGAELHIPTSEDIGTPGRLASWMASSGATVTHLTPAMGQLLSAQATTPIPTLRNAFFVGDILTKRDCTRLQSLAQNVRIINMYGTTETQRAVSYFAIPPASVEPAFLQTQKDIMPAGQGMIDVQLLVVNRNARQETCAVGEVGEIYVRSGGLSEGYLGPPEVTAEKFLFNWLAPDLEIADTLQGTCEGQFWKGPRDRMYRTGDLGRYLPDGTVECTGRADDQIKIRGFRIELGEIDTHLSRHPRVRENVTLVRRDKDEEKVLVSYFVPTDDVQSESEAVQDVKEADIPDGPGRDSLWRIRQYNRLIKDIRDYLKGKLPSYSVPTLFVPMTRMPLNPNGKIDKPALPFPDTVLAQRMAQVSSVQSESRERSHTERAIADVWRQLLPGVAEPVPLDESFFDLGGHSILATRLVFQLRQKLGIHVPLGLVFDAPTIAQLASALDQLRSHESDLAMTPAGGATPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSH6</accession>
    <name>A8PSH6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732484.1">
        <property type="nucleotide sequence ID" value="XM_001732432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSH6"/>
    <dbReference type="STRING" id="425265.A8PSH6"/>
    <dbReference type="GeneID" id="5856790"/>
    <dbReference type="KEGG" id="mgl:MGL_0259"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0259"/>
    <dbReference type="InParanoid" id="A8PSH6"/>
    <dbReference type="OMA" id="GKLWAYD"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="130"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="258" mass="27989" checksum="092111A21E8E15BE" modified="2008-01-15" version="1">MSLESIPADVQNALQTNISMPVQLTVMYPSFQAPDYSTGTDSVVGRIWAFDTVSNLVVLETGNSSALPPAMRRAAASAVYEAGSTRGPSSGLVTGFKIVRASSIKQLKVLNEAQYEKLMPHGPSQLTHISAVPVAAMEVREAAATKKCQERSMQLAPSEASDIGQIVFDAVNKTLPCRWHESHIIVLDEVVISGPSYSVSATYVPSLSRNQLERLLNDDDVDAVQIASHVERAKDKARTWLRVTKVLDGIHTKFALVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSX4</accession>
    <name>A8PSX4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732557.1">
        <property type="nucleotide sequence ID" value="XM_001732505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSX4"/>
    <dbReference type="FunCoup" id="A8PSX4">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSX4"/>
    <dbReference type="GeneID" id="5856863"/>
    <dbReference type="KEGG" id="mgl:MGL_0332"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0332"/>
    <dbReference type="InParanoid" id="A8PSX4"/>
    <dbReference type="OMA" id="AFAIAHW"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="46777" checksum="1F7F93EB6088EF4A" modified="2008-01-15" version="1">MATLCTTWLSVYSVILQLKHYYKPSLQRYVVRILVMPMLYAVASTISLFSLQLAEMIDLMRDLYEAFVIYCFFSLLVEYLSGERAMLTYLHGRPPMPHLFPLNMFFYPMDMSDPYTFLAIKRGILQYVQIKPILAIATVFLKIYGKYEDGHLHLKNGYTWIAIVYNFSVFVALYALTVFWICLHTELAPFRVAPKFLCVKGVIFFSFWQSLLISVIVSTGLIRHIGGIYGDTYMSTALQDFLICLEMPLFALAHMYAFSHLDYIPRTSGLVGRMPFLFALRDSFGTGDVVADTLATVHGTNYTYRSWEPSEDVRHHLYAFKGRSRAGLRYTDDGRTKYWINGNATAHGDEGTPLRIASQTHYLSINNECDELADVHFPKLTQEEEILYQLSRKLPFGDYRYPCIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTJ4</accession>
    <name>A8PTJ4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732659.1">
        <property type="nucleotide sequence ID" value="XM_001732607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTJ4"/>
    <dbReference type="FunCoup" id="A8PTJ4">
        <property type="interactions" value="734"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTJ4"/>
    <dbReference type="GeneID" id="5856965"/>
    <dbReference type="KEGG" id="mgl:MGL_0434"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0434"/>
    <dbReference type="InParanoid" id="A8PTJ4"/>
    <dbReference type="OMA" id="YAFFDFT"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="11"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="310" mass="34048" checksum="5E0DF2F11A720159" modified="2008-01-15" version="1">MRRAHIVIDAFTGVASEVIKNVVLAGIGKLTIVDARSIQPEDLSASFFFRSEDVGTPRIGDAPLQRIKQLNPHVHVDGVSHEGVLSEEAFERLKPDVVLVTQGNRDELIRWNDACRKHSAMFFAAATHGLSGFIFCDLLALEYVEERPVAGAKEKVPVRYRQDFVPLRSSLESRWSFHPSPGLLATWALWSTMDQECANELKDEAAFQGELEKHAQLIMDEHGVKTASVFRRMDAQAYFASFARATFPIVKGQCDAAFAPTSAILGGIVAQSVLNALGRREEPIVNWCILDASRGTADIHSIGPPSAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTU0</accession>
    <name>A8PTU0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732703.1">
        <property type="nucleotide sequence ID" value="XM_001732651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTU0"/>
    <dbReference type="STRING" id="425265.A8PTU0"/>
    <dbReference type="GeneID" id="5857009"/>
    <dbReference type="KEGG" id="mgl:MGL_0478"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0478"/>
    <dbReference type="InParanoid" id="A8PTU0"/>
    <dbReference type="OMA" id="RTRNKFR"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="138" mass="15687" checksum="F73B636C71EDD9FE" modified="2008-01-15" version="1">MSVATPTREQILSLYRAHLATARSFASYNFREYFVRRARDQFRAYLYPQMSVAAQNVNASASKLSNVPTANTAIKPVEPMSAEKLAKFYEEACDELKVLQRAVMTNKMYAGERLVVEDEGRKEWIVRSSEELGHETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUP6</accession>
    <name>A8PUP6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732146.1">
        <property type="nucleotide sequence ID" value="XM_001732094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUP6"/>
    <dbReference type="STRING" id="425265.A8PUP6"/>
    <dbReference type="GeneID" id="5856452"/>
    <dbReference type="KEGG" id="mgl:MGL_0739"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0739"/>
    <dbReference type="InParanoid" id="A8PUP6"/>
    <dbReference type="OMA" id="CILAWIM"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46046" checksum="BC6FFBEC69721359" modified="2008-01-15" version="1">MSYMFSFTAITALKSSTGAIIATILGEYVTRVGMHLLRGPDVGDDYHKFHLAELPSLYVKMIASGAILFIFLTHAFHPIVGPRVQLTVTAAKILLLCCIPILALVMVLMGNVPTESKHAFSSFTGLFDGTTKDVGQYALALYSGLWAFDGWDQCTFVTGELDDPARKVSLAVIASTEVVTLLFLSTVVSYFLVLPPGLVARTNSVALDFGIATFGSTGGVVFAALVAFSCFGALNGHMYTYSHLAAAAGREGYLPRQIGVQHTKFGTPLYAQMLTHTLTLLFVVFGSGFTSLVNFAGVCSWFWYGCTVTCVLVLRIQEPHLERPYRVWLSTPILFSFVAIFLLVMPVFSAPWEALAAFIFIFSGMPLYLITHPQARRAAWSVFASSNAYAFKPIATSAGTTDAQNNIPMWELNESRTHSPSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUW7</accession>
    <name>A8PUW7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0788</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732195.1">
        <property type="nucleotide sequence ID" value="XM_001732143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUW7"/>
    <dbReference type="FunCoup" id="A8PUW7">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUW7"/>
    <dbReference type="GeneID" id="5856501"/>
    <dbReference type="KEGG" id="mgl:MGL_0788"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0788"/>
    <dbReference type="InParanoid" id="A8PUW7"/>
    <dbReference type="OMA" id="NACPLDN"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="113" mass="13169" checksum="F4F9E8BFCA8033BA" modified="2008-01-15" version="1">MSENAMHVEATHEGAPRFQVKKWNSVCLWSWDIQVDNCAICRNQIMDLCIECQANQGSATIDECTVAWGACNHAFHFHCISRWLKTRPVCPLDNREWVLQKYVHTCHDLSWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUZ0</accession>
    <name>A8PUZ0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732209.1">
        <property type="nucleotide sequence ID" value="XM_001732157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUZ0"/>
    <dbReference type="GeneID" id="5856515"/>
    <dbReference type="KEGG" id="mgl:MGL_0802"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0802"/>
    <dbReference type="InParanoid" id="A8PUZ0"/>
    <dbReference type="OMA" id="QSHETEN"/>
    <dbReference type="OrthoDB" id="3366661at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="171" mass="19562" checksum="51609513FB31EA4F" modified="2008-01-15" version="1">MSYHSQYVSQIADATSRWSKIFPPLPARPSLTLPPSNKNEKVFTWEYLSEVFEAFSQRERAMEMRIEALCFNAEQSLQALSDDENIQSHETENANPVLGVRLLQRVDLLQKENDDLAERVKDLMQLSSSEQQIQDLKREVEGSSFRRSLTTDSHKLISALDSALSRMEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVE8</accession>
    <name>A8PVE8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731574.1">
        <property type="nucleotide sequence ID" value="XM_001731522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVE8"/>
    <dbReference type="STRING" id="425265.A8PVE8"/>
    <dbReference type="GeneID" id="5855880"/>
    <dbReference type="KEGG" id="mgl:MGL_0842"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0842"/>
    <dbReference type="InParanoid" id="A8PVE8"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="186" mass="20521" checksum="5197648917C1CD87" modified="2008-01-15" version="1">MSLQYLEEFEIRPESTDQDAAIWQVAWTQHGVVAARASGTVDVIDMKSMLVKTSIKNEHKLGIVALTRSSNDELLLTSSMDGVVTLWQWCDARLTKVAQRASLRGETFDNDAVFQIDVWASALHPQSMLFAAGGENGNVAVFSAEADSFGKGIRHLVHDAPESDFCLSLAFTILSPYALFYLHDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVL6</accession>
    <name>A8PVL6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731634.1">
        <property type="nucleotide sequence ID" value="XM_001731582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVL6"/>
    <dbReference type="FunCoup" id="A8PVL6">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="GeneID" id="5855940"/>
    <dbReference type="KEGG" id="mgl:MGL_0902"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0902"/>
    <dbReference type="InParanoid" id="A8PVL6"/>
    <dbReference type="OMA" id="KLAYARM"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF85">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="557" mass="61561" checksum="AA8CCED2B542BD58" modified="2008-01-15" version="1">MSEKKKEELFGGTTADAVDTVDAVALTGSAEWTDRSCCENGAPLEATLDPTEYKKLERRARFKMDVQVVPLCLLLYLLSFLDRTNIAQAVLDGDPASGQSTKNPGLLTSLGLTPHDYAVALTVLYPTYIALEVPSNLLIKRLGPRIWIPGLVILWGIVETLQGLVSSRTGLYINRIFLGANGGWHSPGIAVYLTFFYTPNELQFRQAFFFTGASLSGAFSGLLAAAIRKMDGIAGQHGWQWIFYLEGIFTVLVGVACIFLMPNEAESCFLLTNTEKQLVRERLNRANDRFRDRHELAAKLEKCECTTGVEDAPQPVPAPWHRDVMRAFTDMRLILTCVLGFCSALSVYSIAYFSPTIVKNMGEYSTIQAMLMSCPPFAVSFAYSILMAIVSDRLRQRYVTIIAGLGLCTIGLAVVLGCKESMTRYGGIILMTSGSFSVPPALFTWLANNASGHYKRATGLALLIVFTNCSGLTSSWLFNTKTESPDFTRGISTNLAIAALGMVISTAIELSILYERKQRQAGRRDERVVSLYQKTGWSNDHMRLYMGDDHPDYHLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW92</accession>
    <name>A8PW92_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="8">2.4.1.132</ecNumber>
            <ecNumber evidence="8">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="8"/>
    <dbReference type="EC" id="2.4.1.257" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731782.1">
        <property type="nucleotide sequence ID" value="XM_001731730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW92"/>
    <dbReference type="STRING" id="425265.A8PW92"/>
    <dbReference type="GeneID" id="5856087"/>
    <dbReference type="KEGG" id="mgl:MGL_1050"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1050"/>
    <dbReference type="InParanoid" id="A8PW92"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="10">
        <location>
            <begin position="36"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="341" mass="38555" checksum="E1FDCE2D92A9B745" modified="2008-01-15" version="1">MQQGKAKGTCEKRPTKGTGAARAPLRVAFVHPDLGIGGAERLVVDAAESLQDRGHTVYILTSHFDASHAFEPTRDGTLEVIHAKTWIPRSLFHMLHLPMAILQQLSLVMQVVVAAYGSSLARHLPHVYRSLTHVPTNSLPDVFVIDQLPTAIPLIKLLCGRRVMYYCHFPDKEISAALARQRGTRGLRALVRAIYRFPLDVLEEATTQWADLIVANSRFTATHFHRVFPRIAKRPSVVYPAVDEAMYTAQHVEREMATYVSTCTMQVGEVGSYAREHLELVQRVIHANDCPMFFSINRFEAKKNIPLALHTVARLRQQAQRETRRPRRAQTTCCHPRPSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWD6</accession>
    <name>A8PWD6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731807.1">
        <property type="nucleotide sequence ID" value="XM_001731755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWD6"/>
    <dbReference type="GeneID" id="5856112"/>
    <dbReference type="KEGG" id="mgl:MGL_1075"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1075"/>
    <dbReference type="InParanoid" id="A8PWD6"/>
    <dbReference type="OMA" id="WITRASH"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="269" mass="30015" checksum="47F1848088E1B0E5" modified="2008-01-15" version="1">MSSALMQVNVFKPESLGTIEIFGTSLSTQTQALLIALQECNVKYIHHPSMPNSPEIANFSPFGKIPVLVHRPNGIYSTRDAVVLFEMTAICQYLTELVGFMECSGRFCLMPKIQDEHSREFADSVVLRSNVLQLNTIVSSYIQTVVEDRYVKPFFALRNNGASDADIHAALTENFDNAMNALIQLEQIITKVQERLHILPETSFILGKEPTWVAVFLFPILRDFRATNPRMVLAGGSQERLPLLTNFVQAFENRASAVNTLRGSFAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWG4</accession>
    <name>A8PWG4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1091</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731823.1">
        <property type="nucleotide sequence ID" value="XM_001731771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWG4"/>
    <dbReference type="FunCoup" id="A8PWG4">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWG4"/>
    <dbReference type="GeneID" id="5856128"/>
    <dbReference type="KEGG" id="mgl:MGL_1091"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1091"/>
    <dbReference type="InParanoid" id="A8PWG4"/>
    <dbReference type="OMA" id="DQIEYMH"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="514" mass="57021" checksum="AE377F034F58F045" modified="2008-01-15" version="1">MNPGDKYKPYTPVNLTDRQWPSNIQRTAPIWTSVDLRDGNQALANPMTEEQKLIFFKTLVSCGFKEIEVAFPSASDTDFGFVRRVIEEGHIPDDVSIQVLTPAREELIRRTFEAVKGAKNVIIHMYNATSPLFRQVVFGNDKARTLELAVRHTKLVRELMDHYSQPAHGGTNFRYEYSPETFSQTEPDFAIEICEAVREAWGLASPSNKIIFNLPATVEIGPPNHYADLIEYFCRNVRDRDSIIVSLHPHNDRGCGIAAAELGMLAGADRVEGCLFGNGERTGNVDIVTLALNLYTQGVQPGPLVLTDLPSVIEVVTSCNNLPVHPRHPYAGELVMTAFSGSHQDAIKKGFAAQEKRWNAGDKVWSMPYLPVDPADLGLTYEAVIRVNSQSGKGGIAYLLTQALGVELPRRMQVAFYRVVQSVAERTSKEISTNDIVQAFSKQYHVPIAGVSKVEGRFSLRSFRLSDEGDDEVVSESMKTNGESTPRHRRFTGKIAHNGEIVDVCGTGNGLFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWH7</accession>
    <name>A8PWH7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1104</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731836.1">
        <property type="nucleotide sequence ID" value="XM_001731784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWH7"/>
    <dbReference type="STRING" id="425265.A8PWH7"/>
    <dbReference type="GeneID" id="5856141"/>
    <dbReference type="KEGG" id="mgl:MGL_1104"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1104"/>
    <dbReference type="InParanoid" id="A8PWH7"/>
    <dbReference type="OMA" id="WMGNFTA"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="22"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="395" mass="44744" checksum="C8A5B9013040AF39" modified="2008-01-15" version="1">MPFHLSEKLSKLIHKGHGSSEHVSVGYFPNWSIYQKGYKPEHVPFQYLTHILYAFANVNPDTGDVYLSDEWADRQIKYDGDEDVGESPMHGNLNQFLQLKKKHRHLKTLLSIGGWSYSGNFQCLTDKQKRERFVQSGVKILADCGFDGLDIDWEYPQSDQEAKTYVDLLSMLRDALDKYGQRATPENPHYLLTIAAPSSPQQYQILRLKEMDKFLDFWNLMAYDFSGSWDQTANHQANLYGGAISVSKAVEDYKHGGVPMNKLVMGIPLYGRGFLGTAGPGQPYERVSETPEGTFLYKDLPTRNAQEHFDERAGASWSYDGREFISYDSPQAACAKAEYIKKHGMRGAMFWELSGDAAHGHERCIVHCVANAMGHLDSSENHIVYPESVHSNLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWN3</accession>
    <name>A8PWN3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="3 12">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1160</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="3 12"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731892.1">
        <property type="nucleotide sequence ID" value="XM_001731840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWN3"/>
    <dbReference type="FunCoup" id="A8PWN3">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWN3"/>
    <dbReference type="GeneID" id="5856197"/>
    <dbReference type="KEGG" id="mgl:MGL_1160"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1160"/>
    <dbReference type="InParanoid" id="A8PWN3"/>
    <dbReference type="OMA" id="ARLYGWV"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="50"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="300"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="532" mass="59968" checksum="B2EDA0273522DF18" modified="2008-01-15" version="1">MLLVFVACTVGVNFISTFAWRKVLRDTNAEKRRRILQDLQLPIGRVRYMFVGFLHPHSHGGGGGERVLYEAILHHQRADPNIVCVVYTGDIAPLPGGVSKQEMLDKVRTQFGIELNENRVAFLPLAYVRLVGDNFWSMFTLAGQAIGANRMGYSAMLQLVPDVFIDTAGHAFTYSAVKNFSSRVRLGAYIHYPTISTDMLQRVRQRRPGHTNPPQIAQSLPRSMAKYVYYRLFAAVYGSALRHADVIVCNGHWTRAHVMDLLQYRIPRPWRTPTLPRLHVVYPPCQTASFTSLPLEGRDPHSLLSIAQFRPEKEHELQLRIVHGLLQKHPELKRPSSSGRALRLTLIGSCRHDADKKRLVALERLAKELMIENHIEWCVDAPFTTMIDKMRTASIGLSTMVDEHFGIAVVEYMAAGLLTLSHASAGPLMDIAVPVSGMQTGFHASCLDEYIDTAYRLMTMPPSTALKVRRIARERAASSFSDVEFHRRWRECMWKELVPPELLVENDRLLKQRAMALQAQAAGASPMPTVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWS1</accession>
    <name>A8PWS1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1198</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731930.1">
        <property type="nucleotide sequence ID" value="XM_001731878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWS1"/>
    <dbReference type="FunCoup" id="A8PWS1">
        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWS1"/>
    <dbReference type="GeneID" id="5856235"/>
    <dbReference type="KEGG" id="mgl:MGL_1198"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1198"/>
    <dbReference type="InParanoid" id="A8PWS1"/>
    <dbReference type="OMA" id="LHPRIMT"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="480" mass="52260" checksum="42B7241643772F9A" modified="2008-01-15" version="1">MSAVELINPRAESVRRLQALQVNIAGAVGLAQVVRSNLGPRGTLKMLVDGSGNLKMTKDGKVLLTEMQIQNPTAAMIARTAVAQDEQCGDGTTSVVLLVGELLKQAERYIQEGVHSRVISEGFDVAKGGALQFLETYKQSSQGDRATLVSVANTALATKLPAKLAKQLAESVVDAVLAIRPRTNSTAEVPKPKADGSSERIDEWKTQDPIDLHMVEIMKMQHKSATDSQLVRGLVMDHGARHPDMPKRVRNAYVLTLNVSLEYEKTEINSGFFYSSAEQREKLVESERRFVDAKLKKIVELKNQVCDAPASTPESERKSFVIFNQKGIDPMSLDILAKNGIFALRRAKRRNMERLQLCCGGVAQNSVDDLSPDILGWAGLVYEQTLGEEKYTFVEDVKDPKSVTLLIKGPNTHTLNQIQDAMRDGLRSVKNAIEDGALVPGAGAFEVAAAAHLLDHVRRNAKGARQTGRGGFCPGADGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWS4</accession>
    <name>A8PWS4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731933.1">
        <property type="nucleotide sequence ID" value="XM_001731881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWS4"/>
    <dbReference type="FunCoup" id="A8PWS4">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWS4"/>
    <dbReference type="GeneID" id="5856238"/>
    <dbReference type="KEGG" id="mgl:MGL_1201"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1201"/>
    <dbReference type="InParanoid" id="A8PWS4"/>
    <dbReference type="OMA" id="FCEHHFL"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="11">
        <location>
            <begin position="50"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="228" mass="25733" checksum="3CEC58EA912AA828" modified="2008-01-15" version="1">MTIIRGFSDEKDPIAAVLNKHGLGWPAKSTLDRLNFSPEEATANEDRLAGAVRTILECLGEDPDRSGLQDTPKRYARALLWMTKGYEERLCDVISNAIFDENHDEMVIVRDIDVFSLCEHHLVPFKGKIHIGYIPNRMVIGLSKLARIAETFARRLSVQERLTRQVALALNEALKPRGVAVVMECEHMCMAMRGVQKPGSNTVTSCMLGVFRDRAKTREEFLSLIRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWU0</accession>
    <name>A8PWU0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731948.1">
        <property type="nucleotide sequence ID" value="XM_001731896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWU0"/>
    <dbReference type="STRING" id="425265.A8PWU0"/>
    <dbReference type="GeneID" id="5856253"/>
    <dbReference type="KEGG" id="mgl:MGL_1216"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1216"/>
    <dbReference type="InParanoid" id="A8PWU0"/>
    <dbReference type="OMA" id="HADYDPE"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="6">
        <location>
            <begin position="117"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="447" mass="50089" checksum="9B31E390A554E44B" modified="2008-01-15" version="1">MNIPRANRPRRSWSWTKAMLVSITRRCTVYICKTHILLAGSPSEKEPVCRKSKFVWIDPADLLEPATPETAGDIRGELKRAMQLQSIKPARISGFFVAATGAPIPTDERACEDERLIVHLHGGAYWMGTANESSVGAVCCRDLLGRMRNSDDVPRRAFLVEYRLARHTNYRHGSYPAALLDSFLAYLYVVRTCGFKPENIILSGDSSGGNLALALCRYLRDEGIESVPGSLILLSPWCDISRSHSGPLPAPNPFSTTVLNGHSDIITPSLLYRNSAVCALLGCMPASEAYTNPYISPVSLQLDPQADVRPPHWGFAGFPKHVFINTGNAELNYEQHITLAHRMAEGTLAGVPKYSGDCAYSADEAHMWAWREQFPRTEKWVSEHDSAMNDPPPHVEPFEERYVVLDEVRDGVHVYPMFTWFEPERSQTLDRIAAWIEREPELRILSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWW0</accession>
    <name>A8PWW0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731968.1">
        <property type="nucleotide sequence ID" value="XM_001731916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWW0"/>
    <dbReference type="FunCoup" id="A8PWW0">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWW0"/>
    <dbReference type="GeneID" id="5856273"/>
    <dbReference type="KEGG" id="mgl:MGL_1236"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1236"/>
    <dbReference type="InParanoid" id="A8PWW0"/>
    <dbReference type="OMA" id="VFGADMK"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="166" mass="18442" checksum="1DAC1057300AF19B" modified="2008-01-15" version="1">MRAVLQRVKQASVHVQGRQVSKIGPGILALIGVCQDDTPEHMDILTKKILQLKLWPEGMRLDESGSLASADEQVRPWRTNVMELGGEVLCVSQFTLYARTSKGTRPDFHLSMGGGEAKPFYDAFLAKMRNMYAEDKIHDGEFGAMMDVSLVNDGPVTISIDTFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWW4</accession>
    <name>A8PWW4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731972.1">
        <property type="nucleotide sequence ID" value="XM_001731920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWW4"/>
    <dbReference type="STRING" id="425265.A8PWW4"/>
    <dbReference type="GeneID" id="5856277"/>
    <dbReference type="KEGG" id="mgl:MGL_1240"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1240"/>
    <dbReference type="InParanoid" id="A8PWW4"/>
    <dbReference type="OMA" id="ACLLEPC"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="281" mass="30974" checksum="BE420BC7C68C2CBD" modified="2008-01-15" version="1">MFPTALPPVTHSVVRLSAADRHVIRRAAVVVGLGNYTHPKTRHSIGQYCLSPLMRLAESHDQALRREIARRVSRLPPDAPTFELPETTPLQSFRHVRASKGWLACVSVLLDSAPSKGSALRRAPDFRLGKYPYVLFDLVFYIPRVLMNVNGTGVASALRMYPDVTLEHAILVHDELQRPFGKVAFKAGGSAAGHNGVRSVQQVLRCSGRSMNQPDIARIRIGIDRPQDPSHDVGAYVLGAMPPAWLTACDFTPDGTPGPVLQQLWQVLHSWCLSHIAPFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX12</accession>
    <name>A8PX12_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732020.1">
        <property type="nucleotide sequence ID" value="XM_001731968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX12"/>
    <dbReference type="STRING" id="425265.A8PX12"/>
    <dbReference type="GeneID" id="5856325"/>
    <dbReference type="KEGG" id="mgl:MGL_1288"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1288"/>
    <dbReference type="InParanoid" id="A8PX12"/>
    <dbReference type="OMA" id="DGPSWMI"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="502" mass="56065" checksum="5E73CA5C1CE385BB" modified="2008-01-15" version="1">MSTQQVDTLVIGAGPTGLGAAKRLNQLNLGSWTLIDANEEAGGLASTDVTKEGFLFDVGGHVIFSHYAYFDDVLAQALPNQDDWYEHQRISYVRSRNVWVPYPYQNNISMLPTEDQVKAIDGMIDAAELRVRAKEPPKTFDEWIVRMMGEGIADLFMRPYNFKVWAVPTTMMQCKWLGERVAAPNLKMVVSNTLNKKVAGNWGPNATFKFPARGGTGGIWKAVAKTLPQENLQFKKKVVKVNAEAHTAYLSDGSLIKYNHLVSTMGLDFLVNTMEGIDSGLKQQLQKAVSDKLVYSSTHVIGIGIRGELPNRIGDKCWLYFPEDDCPFYRATIFSNYSPNNCPQKGAKLPTLQFADPSKGAPSSEPQDGPYWSLMMEVSESHLKPVDNEKVLEDTIRGCVNTQLLLPESEIVSTYHRKFTPGYPTPSLDRDAALQEILPPLLNKYGILSRGRFGSWKYEVGNQDHSFMLGVEAVDRALFGSPEVTLETPDFVNGRRNVERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX34</accession>
    <name>A8PX34_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phenylalanine--tRNA ligase beta subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732042.1">
        <property type="nucleotide sequence ID" value="XM_001731990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX34"/>
    <dbReference type="STRING" id="425265.A8PX34"/>
    <dbReference type="GeneID" id="5856347"/>
    <dbReference type="KEGG" id="mgl:MGL_1310"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1310"/>
    <dbReference type="InParanoid" id="A8PX34"/>
    <dbReference type="OMA" id="FTERRYA"/>
    <dbReference type="OrthoDB" id="2667672at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phenylalanine--tRNA ligase beta subunit B1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="184" mass="21255" checksum="2F7ADB7A95BAAE46" modified="2008-01-15" version="1">MPTVSVDKALLFEGLGHEYTTQEFDELCFQFGIELDDDTTEEVAGTDERPALKIDIPANRYDLLCFEGILRALRVFLKLQEPPMYRLSIPNELVTIRLSPDTAKIRPYFAGAILRNIKFTQARYDNFIDLQDKIHQNLARHRTLVAIGTHDLDTIQPPFVYEALPPNEFRFAPLNREEVFQVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX92</accession>
    <name>A8PX92_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731185.1">
        <property type="nucleotide sequence ID" value="XM_001731133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX92"/>
    <dbReference type="FunCoup" id="A8PX92">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX92"/>
    <dbReference type="GeneID" id="5855492"/>
    <dbReference type="KEGG" id="mgl:MGL_1368"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1368"/>
    <dbReference type="InParanoid" id="A8PX92"/>
    <dbReference type="OMA" id="DGCVNKK"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="506" mass="56090" checksum="47CD5CB15E9321FC" modified="2008-01-15" version="1">MSDGSGGSSQNEAASTVFVGSISPGVSDRWLVQLFQACGGYRSFKRVSKAFGFADFSTLRDALRVLAVLHDLELPSMGSERGKPTKKLIVRADEKTSAFLGEFEKTMVRTDADSLQDAAARARVDYVIQAMSNPNAESGDEPERYEIPSHLKDLSMSEIPVNRRKHVLSEIEKFRLGAVASDAADRKRELELERQRAAALAMRHSSPMSNSGSATPLSKMRDTPDASDHTSTAADDPEVTDERNEADRQRVEASRRARDARQAEHAYLEREQARLATWAEHTLTENASARSMEAWLNLDEDTELARESFWTDRRRWIQRRAEARRREEEADRADRDAEKAENAEAKRQADAFLAELAPMAAGHAPGAPSSAPSWRPSSGAPPLKLHVRQGEMLPGVQRRLDLEQKMRDAPDHAHVIRLVQSLPRTELWGITPAWTRVDLAHIAPTIDAGIAASFGESVPDLQEAVLDKLREHANAQDVADVLEPVLDDEAADVVDQVWRALLLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXK7</accession>
    <name>A8PXK7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731287.1">
        <property type="nucleotide sequence ID" value="XM_001731235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXK7"/>
    <dbReference type="STRING" id="425265.A8PXK7"/>
    <dbReference type="GeneID" id="5855594"/>
    <dbReference type="KEGG" id="mgl:MGL_1470"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1470"/>
    <dbReference type="InParanoid" id="A8PXK7"/>
    <dbReference type="OMA" id="PANYDSQ"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000728">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF9">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="758"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="285"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="814" mass="86527" checksum="88DEABD41F187894" modified="2008-01-15" version="1">MGSAHSRGVRGRDERAQDQDNRIPSVSIPARRDREDAGEHVSSEHSDRRLRRRRLSLGLRSRHLDQEEDMAVDGAPASRTENLSRRIQAGWNRTPLSSLSRRSQSSVSPGPMAAATSPEYEAGTGSAPSVASNTSNPFGRRNSSLSSESSSSRLSRMPYNDMNTPDSNTTTPSNPWEAERASTFRMLERAFGSLPTSSAPSQSRAQPHAHAQPHPRIDPSSLPGTFGQRNARSTNLGPNADRPSSALTSVLAELLSAPREGAPMPMTAPLSGTSVIVQGALIARTASQQDSGEHNLPRTSSSSSTRSAPTPLSAEHAESPGPLPSSTSTSANEPTPTQPTADASSSQSQSGSQNESNIPHVATLEEQGEMLGRILRIAAAATAASVVNQTPLNPSVAASATAFASSAMQQPSSGSDAQPPANDPSIASEPSRTAGTGLGPSSESNSAEGRSPETSRAPDSEVAHDNQSTSSSGAPQEAGFARELLNRLISTRGGAPRQSSLQRNDSEAASSISRLLRDALRASLPQRSAPSSSSSAESDQTTMASVLSTLERARQNQPLPDGEPGSFDRFLRDLLDDLNVAIHQLSASGTTTASTEQDPSNSAHVDEETRERRESDVLSGQLAFFRMFRFERNAESALVPCVMVGVRSLRAEERLMGGEQALPRDGADSRSGVARFVLFVSGGRYHENHPLLSARPRDAGRDLMFIMELLGTIAAMSNKRPTASAADIERSGLAKVRASELVHFRAAGRITENTSDKCLVCLDDWQDEDECRILSCKHVFHASCVDQWLEHSSNSCPLCRTEAVSTTGVASAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXU8</accession>
    <name>A8PXU8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731346.1">
        <property type="nucleotide sequence ID" value="XM_001731294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXU8"/>
    <dbReference type="FunCoup" id="A8PXU8">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXU8"/>
    <dbReference type="GeneID" id="5855653"/>
    <dbReference type="KEGG" id="mgl:MGL_1529"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1529"/>
    <dbReference type="InParanoid" id="A8PXU8"/>
    <dbReference type="OMA" id="ECLWIHL"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="8">
        <location>
            <begin position="15"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="769" mass="84498" checksum="C8F5F2A497EF707B" modified="2008-01-15" version="1">MSNGNVVLTHPNIHDGWFHEENPQWPGQAMSLRVRRILHHEKSQYQDVLVFESETYGNVLVLDGAIQCTERDEFAYQEMIAHLPINSHPNPRRVLVIGGGDGGVLREIVKHESVEEAILCDIDEAVPRVSAKYLPKMAEGLNHPKSTVIIGDGFAFLNDPKNKASFDVIITDSSDPEGPAEVLFQKPYFELLKQALRPGGHISTQGESMWLHLQLIRSLTQATKELFPVADYAYTLIPTYPSGQIGFVVCSLDANRNVREPLRTVPNCSYYNNDIHRASFILPQFAHRVVVDGQPAPGPVIATGYGESRDAHTPPKKVLVLGSGYVAGPVIQYLLRFPQFSVTIGSARHAAKLGKQFPRAQTMQVDVKEAASLSAAIQQHDLVISLIPYIYHADVIKAACQHKVDVVTTSYVSDAIRALEPEIKAAGITVFNEIGLDPGLDHLYAVKAIKDIHDAGGQVKSFLSYCGGLPAPEAATNPLGYKFSWSSRGVLLALRNTAKFIQGNQAHTVSGLDLMATARPYYIMPAFAFVAYPNRDSTPFREWYGIPEAEECIRGTLRYQGFPELVLALVRLGFLDESAQDWLASKDLTWSQLTARLVGSSATDEASLVRAVRERCAFQNDEDAQLVLRGMRWLGLFSNEPVKVGGLPEQLASGTGNLLDTLCVNLEGKCAYEPGERDMVMLQHRFSVLTKDGEHKTLTSTLLDYGVPNGTSSMAKLVGVPCGIAARFVLEGHPAIKKPGILAPYSFDVAEPIRLELVKEGIALEEAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY90</accession>
    <name>A8PY90_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1615</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731432.1">
        <property type="nucleotide sequence ID" value="XM_001731380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY90"/>
    <dbReference type="STRING" id="425265.A8PY90"/>
    <dbReference type="GeneID" id="5855739"/>
    <dbReference type="KEGG" id="mgl:MGL_1615"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1615"/>
    <dbReference type="InParanoid" id="A8PY90"/>
    <dbReference type="OMA" id="MRYAGEM"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="556" mass="62127" checksum="75C5A3E9AC4E6319" modified="2008-01-15" version="1">MASQGNHHDEQNTHTEPYPLLGMDISMFSKAGFDMDHVSLKRNAPVAQLYEEAVRKEGAVIASSGALINLSGKKTGRSPKDKRIVYEETSKDDIWWGPVNIKLDEHTFEINRERAIDYLNTRDDIYVFDGFAGWQPKYRIKVRVICARAYHALFMHNMLIRPTREELENFGEPDFTIYNAGHFPANRFTTGMTSSTSVEINFKRHEMVILGTEYAGEMKKGIFSVMHYLMPAKFGQLSLHSSANMGDKGDVSIFFGLSGTGKTTLSADPSRKLIGDDEHVWSDHGVFNIEGGCYAKCINLSAEKEPEIYGAIRFGSILENVKFDEATRDPLYDDSEITENTRCAYPIEYIPNALIPCMTTTQPSNVIMLTCDAFGVLPPVSRLTSEQAQYHFIAGYTSKTPGTEDGVTEPSPTFSTCYGQPFIVLPPQRYASMLAERMSHVNCNAWLVNTGWIGGKYRVGRRCPLKYTRAILDAIHDGSLANAEYDQFAPGVFDLRVPRAVNNVPSEVLNPANSWPDKAAFEAELKKLAGMFAEAFVTHEKEVNPEVLNAGPHKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYF9</accession>
    <name>A8PYF9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731471.1">
        <property type="nucleotide sequence ID" value="XM_001731419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYF9"/>
    <dbReference type="FunCoup" id="A8PYF9">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYF9"/>
    <dbReference type="GeneID" id="5855778"/>
    <dbReference type="KEGG" id="mgl:MGL_1654"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1654"/>
    <dbReference type="InParanoid" id="A8PYF9"/>
    <dbReference type="OMA" id="YRHRHLM"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="34"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="302" mass="34530" checksum="68280B258D113990" modified="2008-01-15" version="1">MSTVYNTALKREAAAGKKRESEEQNDVQLRRNKQRVLMLPSRGITARMRHLINDLEALLPHAKKDSKLDSKSDLSVLNELADLNNCNNCMYFEARRHEDLYLWLSKTPNGPSAKLLVQNVHTMDELKMTGNCLKGSRHILSFDKGFDAEPHWTLMREMLTQIFGVPRTARRAKPFVDHILSFSILDNKIWFRNYQIIEKDPGAIAAAEAQGTDPKKAQTEPTLVEIGPRMVMTPIRIFEGSFGGPTLFDNPEFISPNAVRHAMRRGKGEEYKTRVLQAENLRMKRDKYKGEESELSRANVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYK0</accession>
    <name>A8PYK0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">MGL_1677</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731494.1">
        <property type="nucleotide sequence ID" value="XM_001731442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYK0"/>
    <dbReference type="FunCoup" id="A8PYK0">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYK0"/>
    <dbReference type="GeneID" id="5855801"/>
    <dbReference type="KEGG" id="mgl:MGL_1677"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1677"/>
    <dbReference type="InParanoid" id="A8PYK0"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="BRENDA" id="1.6.2.4">
        <property type="organism ID" value="13511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="56"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="257"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="444"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="462"/>
            <end position="464"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="479"/>
            <end position="482"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="628"/>
            <end position="629"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="638"/>
            <end position="642"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="713"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EDP44280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="714" mass="80025" checksum="B9229857EB149576" modified="2008-01-15" version="1">MAGITLWLVAGLVGLITVFILRNTLFKSQEVAEPIEEDDGDGSNFVERLELQKKRIVIFFGSQTGTAEEYAIRIAREVKSRYGTSPLVVDPEPEEFDKLDLLPENCVAVFVMATYGEGEPTDNAVAMMDFLKSPDVAFTNGSTLENLHYVAFGLGNRTYEYFNEAIRQLDARLLELGAHRIGERGEGDDEKGLEEDYLAWKDPMFEELAAYLELEEGATGDVSDFAVTECDSEMPSVFRGEYHSRGLMGLSGNHDARNPCPAPVAHTRELFVEGAASRSCVHVEFDISGSGITYQHGDHLAVWPSNPEPQVERFLAVLGLWEKRHTVINVKSLDPQLAKVPFPVPTTYEAVARYYLDIDAHASRQALASFAQFAPNEVARDELVRLGKDRDYFRERVSDHCYKIGQVLQLVAGDSLADDDILKSTPWPIPFDRVISAIPRLSPRFYSISSSPKLSPDRIHITVVGLRYTPPQASFDTFGLASNFLSAVKMAVHDETPALGDPRYGAPLYHLGGPQGKYMSTDESGRKNIKVPVHVRRSNFRLPTSTKVPIIMVGPGTGVAPFRSFVQERVATARKAKDKLGSEALNDWADLHLYYGCRRSDEDFLYCDEWGQYAKELNDKLKLRLSFSREVFKPDGSKLYVQDLIWEDREYLADAILNKRAYIYICGEGKSMCHDVESTLARILGEAKGVDEEAGRAELKQLKERNRMMLDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYV2</accession>
    <name>A8PYV2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="12">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALA1</name>
        <name evidence="15" type="ORF">MGL_1729</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="12"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731546.1">
        <property type="nucleotide sequence ID" value="XM_001731494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYV2"/>
    <dbReference type="FunCoup" id="A8PYV2">
        <property type="interactions" value="596"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYV2"/>
    <dbReference type="GeneID" id="5855853"/>
    <dbReference type="KEGG" id="mgl:MGL_1729"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1729"/>
    <dbReference type="InParanoid" id="A8PYV2"/>
    <dbReference type="OMA" id="NKKDNFW"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="14">
        <location>
            <begin position="12"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="923"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="927"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="730"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="963" mass="107230" checksum="6364F8EE0E6C32DB" modified="2008-01-15" version="1">MSNSSATVVNEWPAAKVRSTFLDFFREKEHTFVPSSSTVPYDDPTLLFANAGMNQYKSIFLGTVDPSSEFSKLRRAVNSQKCIRAGGKHNDLDDVGKDTYHHTFFEMLGNWSFGDYFKEEAISFAWKLLTEVYGLPSDRLYVTYFEGDPKQGLEPDVETLEIWRKVGVPDERILKGNAKDNFWEMGATGPCGPCSEIHFDRVGGRNAASLVNMDDPDVIEVWNNVFIQFNREEDGSLRPLPARHIDTGMGFERLVSILQDKRSNYDTDVFMPLFSRIQELTGARPYSGKLGAEDVDGLDTAYRVVADHIRTLTFAISDGCIPDKDGRGYVLRRILRRGTRFVRKYFQVPIGAFFSQLVPTLVEQMGSFFPEITRKTKELQAILNEEEQSFARTLDRGEKLFEQYANAARTEGRTKLSGADVWRLYDTYGFPVDLTSIMAEEQGLTFDQAEFEKAQAESKEASKGQGKQQEALAVKLDVHDLGHLDADASVPQTNDVFKYDTPSMQAHVKAIFQEHKFVSDSNSLAKAGEPFGILLDQTNMYAESGGQQADTGSLVIDGKAEFEVSDVQASNGYVLHIGFLKYGKLSVGDQVVVSYDESRRRPLQNNHTGTHILNFGLREILGDHVDQKGSLVAPSKLRFDFSHKAPVNVSELQKIEDISNSFIERDVSVYAKDMVLEEAYKIPGLRAVFGESYPNPVRVVALEFDIDQMAKDLTNPRWRQTSIEFCGGTHVKKTGEIGRLVVTEESGIAKGIRRIVAVTGDEAVAVTATADEASKRLDEIDQVSDDVAKEAQLKAFSVELARMDISVVRKDELKARFTKIRKALDTRLKARAAADVKVAQEAVQTYFNENPDARVYIAQLDTGANSKALQSGVAVARKLNKSVYLFARESGSEKTKTLYGNFVPKDELERGLDAVSWNKAVSEKLQGRGGGKPDGAQGQGEGTKADVDEAIKLAQSFFDMQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYV6</accession>
    <name>A8PYV6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731548.1">
        <property type="nucleotide sequence ID" value="XM_001731496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYV6"/>
    <dbReference type="STRING" id="425265.A8PYV6"/>
    <dbReference type="GeneID" id="5855855"/>
    <dbReference type="KEGG" id="mgl:MGL_1731"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1731"/>
    <dbReference type="InParanoid" id="A8PYV6"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="142" mass="15444" checksum="B53EA311ACBAE59E" modified="2008-01-15" version="1">MKYAIRGLAESLRSELQMHGIQVHMYFPATILSPGLEEENKSKPQLTKDIEGTDEGLTPEACAQHLLRGVERNEFSITDGLVGLLLRISSGGCAPGNNFLLDSIFMLPSRIQLKLCTSVILKCSQTGFDSCSLAPHVLASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ49</accession>
    <name>A8PZ49_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730889.1">
        <property type="nucleotide sequence ID" value="XM_001730837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ49"/>
    <dbReference type="FunCoup" id="A8PZ49">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZ49"/>
    <dbReference type="GeneID" id="5855196"/>
    <dbReference type="KEGG" id="mgl:MGL_1888"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1888"/>
    <dbReference type="InParanoid" id="A8PZ49"/>
    <dbReference type="OMA" id="VCWMRLE"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="263" mass="29145" checksum="9EFA2FE85935A349" modified="2008-01-15" version="1">MSPAGRDGVQVWTTLDVNTVFTNYKIESHNNNEITVEVSAESLARVLRSAVGALEVMLRLGKRDREPLLSWSIAMTSQNGTRLDVVQELVVRILRASELALIVEPMCPTPDVYIVMPPLSEMHAMSELMRTLSSYVSLSANQQGTLKLSLSDQHVEGSACWFQLEHPQVHTQANDNHASNTSPDAFHEVHISMKAMQNVFSCASMAKSTVACICAGYCVVFYVYISGASQHRSIHQTNGPQQVRGVVNFKFKFHQPEAVSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZD5</accession>
    <name>A8PZD5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730911.1">
        <property type="nucleotide sequence ID" value="XM_001730859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZD5"/>
    <dbReference type="FunCoup" id="A8PZD5">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZD5"/>
    <dbReference type="GeneID" id="5855218"/>
    <dbReference type="KEGG" id="mgl:MGL_1910"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1910"/>
    <dbReference type="InParanoid" id="A8PZD5"/>
    <dbReference type="OMA" id="RPKVQPC"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="364" mass="41782" checksum="0CA977503CD96AC6" modified="2008-01-15" version="1">MAHNQRPVTVPCAYKTGRTLGQGTYAVVKEAVHIETGKYYACKVISKQLMRGREHMVRNEIASLKRVSQENSGVVSLVDYFETMNNLYLVTDLCQGGELFDRICERGSYYEKDAAHIVRTVTKAVEFLHDRDVVHRDLKPENLLFRDRSEHADLLIADFGLSRMLDQDKMDVLSTTCGTPGYMAPEIFKKTGHGKPVDMWALGVITYFLLCGYTPFDHDSQKDEIQRILTADFRFEPEIYWQGVSQEARDFICRLLTINPETRMTAKEALQHPWLANVSTSLDTVQRDLLPDIKNAFNAKRTFRKAVNGIRMINRLRSETIEHQSARQEMEQQHRLAEEESSNLDRVWQAEAARAQERPAGHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0G0</accession>
    <name>A8Q0G0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731028.1">
        <property type="nucleotide sequence ID" value="XM_001730976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0G0"/>
    <dbReference type="STRING" id="425265.A8Q0G0"/>
    <dbReference type="GeneID" id="5855335"/>
    <dbReference type="KEGG" id="mgl:MGL_2027"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2027"/>
    <dbReference type="InParanoid" id="A8Q0G0"/>
    <dbReference type="OMA" id="CHNVLAW"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="541" mass="60369" checksum="8904DA75C3586E3F" modified="2008-01-15" version="1">MLKSSATLSLELVAARHDENVEKDAMRLMEDLACNAERIPARDMVISLAKYVPALNLDIQLDALDTAQWQDPWCRPVLTRRAEDLLEATDVTYDDVTCILTEYIRPIFQQQHRDKHSYGQRAASHLREWKDDTDMPAWTRTEPNSHGHIPIGCHNVLAWLISQLNRLTSSSSSSHAPLPGLTSAAKEPLRTSREWDQVWPLVLPPVITWLDTPNPREKILGACIAQRLIRFAPPALLVRTGIDRLLRESVSRMLSFMTDAHRGPLVLCTAMQGRLALISRLPMDHQFDAQASLFSDAVLTALSYCAPASSSTQALLPVDSTRTATLSSPRLQQALAYTACTCAQSLLCRMGEPSLRFWNAWMDWACAWLEHALGAVHAPFPVPSAYACPARPMSDMVDEIIEHGHLKSDSHGPRSAVSDWVDAGRVLLHSLHACVQATQTLVEYATDATVVDTPLPTHAPGLRVWMPRLMAAACKCSIRLQDLDIQEPPVVHTRASTLLASLQTLCYTILRTDDSFYTVRMCLAREDDLLYERAPPSLYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0P3</accession>
    <name>A8Q0P3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731063.1">
        <property type="nucleotide sequence ID" value="XM_001731011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0P3"/>
    <dbReference type="GeneID" id="5855370"/>
    <dbReference type="KEGG" id="mgl:MGL_2062"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2062"/>
    <dbReference type="InParanoid" id="A8Q0P3"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="434" mass="48286" checksum="DE58AF6EFE93F153" modified="2008-01-15" version="1">MSSSSSRSHKLVTEHDISSDSNKKRKGALGHEMEEAAKPKRRIYGPDFPVHESYMPKSPTLGAHRHSDHVTLASSTTNGSNVSNMNRTRLSHPVQSYGYPSLTGRVSPPYIFAGGYGRSGHTNLDSFLGSGLIPPLMTPLKNSFSSMERHRGRPYLKPLPSLSPEPAFYPSSTASKAPHNSTDLPFHHSKIGKDSNPLRYSAFLSTVDSEKGLLLPSMLDRSRESLSNLPVRSLDPHSTSHSDWSPLSAEQRYNDRPYVSPSLDFRERNTDFGHTKPLSAGTLDAAALKPEVRKPTFLPHLATRYDRDDLDVKYNRSSNIESYHSFQSRPLSYEARRLASERLPEERKSVHSSSNGGRLLTHPTSTRPISRDLVYREGIDGFLGRRDLRKVPSLKPFKSLESQSSPHAVPSFNQDGSGYSSICPGAHRRYALIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1C8</accession>
    <name>A8Q1C8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730769.1">
        <property type="nucleotide sequence ID" value="XM_001730717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1C8"/>
    <dbReference type="FunCoup" id="A8Q1C8">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1C8"/>
    <dbReference type="GeneID" id="5855076"/>
    <dbReference type="KEGG" id="mgl:MGL_1768"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1768"/>
    <dbReference type="InParanoid" id="A8Q1C8"/>
    <dbReference type="OMA" id="KEHEWIR"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="62"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="144" mass="15835" checksum="A2EF9B63BD0257FE" modified="2008-01-15" version="1">MIAAPLRSACFSSLRSAMRPVPRALPRVNMVRTFRSSSITNRVKTLYTLEHEWIKYDDETNEGVLGITDHAQNSLGDVVYLELPSVSLEVTRGDQIGSIESVKAASDIYSPVSGIVAEVNEKLNDEMSLVNKSPMEEGALSHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1T5</accession>
    <name>A8Q1T5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730837.1">
        <property type="nucleotide sequence ID" value="XM_001730785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1T5"/>
    <dbReference type="STRING" id="425265.A8Q1T5"/>
    <dbReference type="GeneID" id="5855144"/>
    <dbReference type="KEGG" id="mgl:MGL_1836"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1836"/>
    <dbReference type="InParanoid" id="A8Q1T5"/>
    <dbReference type="OMA" id="PHCEKRY"/>
    <dbReference type="OrthoDB" id="2333993at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="746" mass="78834" checksum="6DA64C49FC540BF9" modified="2008-01-15" version="1">MTSLEAPSSTSRDVPAWLWASGIPPAAPAAPSGGAGTSPALYWDMGLSLHERPIHSQSPSRCMMYRNDSGAEHGMFPPHSLIPPPVPAGTSAAGTGNTTGAGTAASATTPESTHAHLPPPHAMYPPSTAFHVPMHPEPAPGYSSVLSFGPGSTYPFFDAQGFPMLMHVPPGMAPSYPMAQQQEHIPSLIESSRADSFSDTWSTLSSVTSDAPSSMHPQAQSTTTSMDDLLALSRQAQNDGEGGQNPNIFVCPHCEKRYTGKHARSIWRRHLQDKHAIPLSVQPRRTRWDRDMNRPRNAAERRERMLESKRRWARKKREQERRVAAANRGASVATDTATPTPSDPDVDQFDALSKEMASTMHSVTKPSLPPSSSSMHMPIHLPPPAPPPASASASSAAPAVTSSSSSAPNRTALAPRDINIPSSQNWRTDAGAGIVKSPGFLDSKLFMPSPLQSTPLRSALSNPPSLYGTMHSPSDSRTAPDSARRFLPFPHPPSSLTKRTPSERSKFAAFTRIEPSPRKLGLGGQASRADAPASPSVRSVRASRGDQFSSPQHLNLTQSLGLAPHSATKGGGTGFTPSFSSNVHMTPLGAGGGTPFSRMPLGLTPSIHGFLRGTGGGLGGLSASATGSGGGDMSGSGLLGGGDFSGYMMGLTTLDSPHILRSASRPSPLRTGVSFHSSSERDEDDDLDHEGEMRIISPSLRQRVRGNAKASPLGQDTPSKVGSPLRGPGSFSFGLRRTPHRAPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q247</accession>
    <name>A8Q247_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730678.1">
        <property type="nucleotide sequence ID" value="XM_001730626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q247"/>
    <dbReference type="STRING" id="425265.A8Q247"/>
    <dbReference type="GeneID" id="5855003"/>
    <dbReference type="KEGG" id="mgl:MGL_2132"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2132"/>
    <dbReference type="InParanoid" id="A8Q247"/>
    <dbReference type="OMA" id="FCELWMR"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000014">
        <property type="entry name" value="Cation efflux protein/ zinc transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="459"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="775" mass="86000" checksum="E7BC08B61CA4A3DF" modified="2008-01-15" version="1">MAVAQAMMPAQPDPRQRGKVKLDALRSSSLNVSHKIRIHHLLALLVTKTMVASAAWLTRQWLLVPQVDTDFLQLQQDGILSSDAGHMVAQDNLVHEPASLWAVATVSMSMAAFFLLTTLRVWRWDIELTSHAVRHLLVLGAVVFLQLIFWLMSLKYLGATFTLIFTQFCELWMRDIQFGRRWSKSGGMLVILSMCMSFAVATLTHSSVSLRRPYADTLDNIMIRTLTFKASLQDRVSVWDLCKGFAALLVHAVLSMELGHLVSTTARHVGGRRRAMVLATSFAAAILLPLSTLGAICGFKLLPAPLVPGREPTAQDALEINHLAAYLVLGIGLLMLDVLVTLTLESYVTLIMHVAHAWPMVVFAAMAIGFAVFNVNVSFIQVVCAACVGFALRAILRRSPLYMTSWYRRATIEEQRVAMAGSDSDTTLLTDLVVLTYRFMIQLRHMINVILKNRDSRRIFLFLCLNLSFMVVQLVWGVWTNSLGLISDAIHMFFDCAAIFMGLVASVMASWKTDDKFPFGYKRVEILSGFANGIFLVLISVFILFEAVQRIIEPPIMTNMTQLLIVSTLGLVVNLFGMFAMGHHHHHGHSHGCHDHHHHGHDNGHSHNMLGLYLHVMADTLGSVGVIISTILIHYFHWTGFDPIASLLIGLMILGSVVPLVIDAGRILCLELGKDDANALQCALEKVKALPGVVSISDPHFWPLDGESIVGTIHVFYDTPLTSLTNDKPVSIDPSTLAVEVETVLRSWVQSLDTLHVQMHPTDPTVLAPEKHFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q266</accession>
    <name>A8Q266_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730697.1">
        <property type="nucleotide sequence ID" value="XM_001730645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q266"/>
    <dbReference type="FunCoup" id="A8Q266">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q266"/>
    <dbReference type="GeneID" id="5854993"/>
    <dbReference type="KEGG" id="mgl:MGL_2151"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2151"/>
    <dbReference type="InParanoid" id="A8Q266"/>
    <dbReference type="OMA" id="YKMSVPK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="112"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="220"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35085" checksum="F80352451F66653E" modified="2008-01-15" version="1">MDESYSWWMRWCNESHPCKSVREIKKQVQPASADGKKTYPGVWKGLSRIWQEEGFYGFMRGNGLNCLRIAPYSAVQFATYESMKRALLRFSSFRQQHLGFSDKASSSHSTELHTFERLVAGAVAGFTSVVSTYPLDLVRARISIASASMYTTAGTSTTVLPRVPGVWETTMKVYRDEGGFRGLYRGCIATSLGVAPYVAFNFVFYESARSFLTKSDGTPPGPFTKLCIGAFAGAVSQTLTYPVDVVRRRMQVSGMKNSSLGVQDKGGLDSLRNMVAANGIRGLYHGLFPNLLKVAPSTGAYFLTYELVVSLFSNMWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2X2</accession>
    <name>A8Q2X2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2261</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730465.1">
        <property type="nucleotide sequence ID" value="XM_001730413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2X2"/>
    <dbReference type="FunCoup" id="A8Q2X2">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2X2"/>
    <dbReference type="GeneID" id="5854772"/>
    <dbReference type="KEGG" id="mgl:MGL_2261"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2261"/>
    <dbReference type="InParanoid" id="A8Q2X2"/>
    <dbReference type="OMA" id="MIRYLTF"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725074" description="Mannosyltransferase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="374" mass="41295" checksum="307CF72E5024E8C0" modified="2008-01-15" version="1">MSVRMNSAIPAGVLLGALSAQVWLAPLTKVEESFSLQAVHDILTYGVYPSGRDHYDHLTFPGAVPRSFVGPLILSIFSAPFSWICGLLGGTSAHVQVCVRMVLAVATWTSFVFLAHCLFPKTSRLRGFFYIVCSVQFHLLFWSSRTTPNGLVFPFVTASLGAIIHGRHAYVGLVALASLAIILRLELVCLAIPSYLWVWLHQRRRFFVLFLLGMVSCLCSVAVSMMLDSYFWKQRMLWPEGYALFFNVIQGHSADWGTSPPWAYLVQDLPRVLGGALPLALVGCARRRASTRTSLLVHIVVHVGLMSALAHKEWRFVMYVVPLCNALAALGLEALWKKRIGIFLSIALLCMSAAFCALATWISMSNYPGGEALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3C6</accession>
    <name>A8Q3C6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2361</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730565.1">
        <property type="nucleotide sequence ID" value="XM_001730513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3C6"/>
    <dbReference type="FunCoup" id="A8Q3C6">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3C6"/>
    <dbReference type="GeneID" id="5854872"/>
    <dbReference type="KEGG" id="mgl:MGL_2361"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2361"/>
    <dbReference type="InParanoid" id="A8Q3C6"/>
    <dbReference type="OMA" id="HYLRYHH"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="245" mass="26936" checksum="CFACD00648B0AB7A" modified="2008-01-15" version="1">MEVFLGTHAPQELGPGNVWVTLTFAQSQDGKIAGANKRPLRLSGEKSMNMTHHLRAMHDAILVGIGTVLADDPRLNVRLDNYSGLSPRPVILDCHLQMPCECRLLQRVPRADPLVLCAEPADQNARKAWETRRQALEHAGAHIRTVETFTNPQGKLHLAWPSILHVLAHEQLHSVMVEGGAAVIDSILASHHLLHKVIVTVSPVRVGEDGVGYTATPLQHAPYLQHIDTLELPPDTVFAWDVVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3F2</accession>
    <name>A8Q3F2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein LEU5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730584.1">
        <property type="nucleotide sequence ID" value="XM_001730532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3F2"/>
    <dbReference type="FunCoup" id="A8Q3F2">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3F2"/>
    <dbReference type="GeneID" id="5854891"/>
    <dbReference type="KEGG" id="mgl:MGL_2380"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2380"/>
    <dbReference type="InParanoid" id="A8Q3F2"/>
    <dbReference type="OMA" id="VYERMKW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="109"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="239"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36651" checksum="48D067B58A37956C" modified="2008-01-15" version="1">MTQRHRNSWDYVLRSGLAGGVAGCAAKTAIAPLDRVKILFQASNPDYQKYSGRWLGVVNAMDNIVKQQGVMGLFHGHSATILRIFPYAAVKYMAFDMFRLVMMPTPRDETSLRLFLAGSMSGVLSVFITYPLELIRVRLAFDTKTKPQAGSLRNIVTNIYHEGAEIVTNDGSHKSTLLNRMPLLKFYRGFGATVMGMIPYAGTSFLVFGRTKAWLYTVLLNKDTQGTPLSEHPPLFDLNRTVVDLTAGALAGAISQTASYPFEVIRRRQQVGGLLHPSRMMGFTETVRWIYTTRGILGFYIGLGIGYLKVVPMTAISFAVWSEMKCILGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3F3</accession>
    <name>A8Q3F3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730585.1">
        <property type="nucleotide sequence ID" value="XM_001730533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3F3"/>
    <dbReference type="STRING" id="425265.A8Q3F3"/>
    <dbReference type="GeneID" id="5854892"/>
    <dbReference type="KEGG" id="mgl:MGL_2381"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2381"/>
    <dbReference type="InParanoid" id="A8Q3F3"/>
    <dbReference type="OMA" id="SINECMS"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="434" mass="47800" checksum="73831DE5918D507C" modified="2008-01-15" version="1">MDDLDFGQYVASHSADPSACNGAHGGLLASVRDWVFSMQAYAMAAYGLQSSAMSKASHRIGTCHRGLVQHALAEQHMHNAMQALTQAVVHAERLSRELAQRTSSLDENNRQVHLRQVQLRNEQQHLDTLRQKLEHERTSLKHKLKHAAQTKRELAEQHDALERRGQSMEKEQQAQAMRTQEAIACAKSQSAEAIRKAALAEEAAMQRASEAEDRARAAEERASDMADALHATRAKNQSMADQMRALQAALASNKSKRRSERETSDRLRSRVFQLEHERDASASPLRERSINECMSLSRSRQGHHVPETPDAGAKRKRATGVGAGANTDAGVAASFETETDPHLSASSEFAPTLISLKPRAESSAPTPSPSQAFLSSLTYDMDDNEFPMPGGSWPTMNQPHSRISPHKHTAVSDSLWIHSSTQGTVALGPRRRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3M3</accession>
    <name>A8Q3M3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730651.1">
        <property type="nucleotide sequence ID" value="XM_001730599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3M3"/>
    <dbReference type="FunCoup" id="A8Q3M3">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3M3"/>
    <dbReference type="GeneID" id="5854958"/>
    <dbReference type="KEGG" id="mgl:MGL_2447"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2447"/>
    <dbReference type="InParanoid" id="A8Q3M3"/>
    <dbReference type="OMA" id="SPFFMNA"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="57"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="225" mass="24755" checksum="32A820B127BF999E" modified="2008-01-15" version="1">MSDITLQPYQSEYIDLALKWNILRFGGPFKLKSGRESPYFFNAGLFNTGHKLQKMAECYANRIVESGIEFDVLFGPAYKGIPLVAATALELARIHGRDVPFCFNRKQTKSYGEGGNLIGAPLQGRVLVVDDVITAGTAINEAVDIISAQPDASMVGVVIALDRQERASEETTESAIMQVEKRLGVKVYSVVTLAQIIKHMEVTRGDSARADIESMQAYRQKYGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3U3</accession>
    <name>A8Q3U3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730087.1">
        <property type="nucleotide sequence ID" value="XM_001730035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3U3"/>
    <dbReference type="FunCoup" id="A8Q3U3">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3U3"/>
    <dbReference type="GeneID" id="5854405"/>
    <dbReference type="KEGG" id="mgl:MGL_2469"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2469"/>
    <dbReference type="InParanoid" id="A8Q3U3"/>
    <dbReference type="OMA" id="WSALHAP"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14797" checksum="97876A69BD5A6490" modified="2008-01-15" version="1">MFASSVLRAPRIPRSALSTQPRLGGAARTFAIPCRKVVVEYCEKSVASKGTRDYLLQQAVSIARAYPSVEFVVIPRPQKSPVLRGFYPTQVGPKMQLILDASGAKTHHLKRTPVASSNESARGVWSPMHDNLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q464</accession>
    <name>A8Q464_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730121.1">
        <property type="nucleotide sequence ID" value="XM_001730069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q464"/>
    <dbReference type="STRING" id="425265.A8Q464"/>
    <dbReference type="GeneID" id="5854428"/>
    <dbReference type="KEGG" id="mgl:MGL_2503"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2503"/>
    <dbReference type="InParanoid" id="A8Q464"/>
    <dbReference type="OMA" id="RKHITER"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12812" checksum="FEDA16BC4730B516" modified="2008-01-15" version="1">MYFSLYALETPKPQDDIQWLTYWVVFGFFNFVETFVNFVLYWFPFYYTFKTLAIVWLMLPQTQGAKLVYHRILRPAFLSITGSTPSTRAPATAADTSKTGFAASSTGGLHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4D2</accession>
    <name>A8Q4D2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2526</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730144.1">
        <property type="nucleotide sequence ID" value="XM_001730092.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q4D2">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4D2"/>
    <dbReference type="GeneID" id="5854451"/>
    <dbReference type="KEGG" id="mgl:MGL_2526"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2526"/>
    <dbReference type="InParanoid" id="A8Q4D2"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="123"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="123"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1066"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1066"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1094"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1847" mass="205060" checksum="236E1E8E2CA5CC0D" modified="2008-01-15" version="1">MDHASAVVELLPRIASIPIPGNPDTYRVPAARAREVRQRLCHELLSTVPVTSLFPASIASTSADAFALLDQCDWHITMAQQRAETLQDAHASAAAAAAAAAPSEGVAATASSQPEYSKNRRGMACGHVFRKGEPIFRCHECSFDDTCVQCAMCFRHSIHAREDHDVVFSVADEGGACCDCGDEEAWNRDLGCEFHSLRPHNAPEHESGEQVPRGEQTLDEILGIVPENVQQDLGEFVALLSAFLLETFLHAPKQTQLVMGPDVVDSIKRQPSFENAFPAKGKARQDMSDGAERDPQPPLFVALLWNDEKHSFNEVSDKILEVCTTMTPKDARNFAEAVDRHGRQVVAMSDDVRRLVLMARRIGVIYLLVTVQHAFDYYVEEVAGCVLEFLMELASCSLYSADATSDGRMIKAQITKTLLRPWLVPEWAEAPAAIRRDLFDPTRLCILDTLLLLDTKMWKGARLQMRHLLMDLLACREAKRQIALRFGAVYPKLVEAFILHDREPEHSIYHMTVQLFSVPSIATQLVVERQFLVVLLYVLQALFANDNETRITSLVLPAPLPARGQASPDTALLRQQKCYHIFYDIRYLLGARDVQLDIVKHAEMYLGMWLEFFALFHGMAPDKRAVHAHVEFESELWIQVFHINSHLGRIAKLLGEAFAGADNARLCEAIGFIGTTILRHMARLSALDPATHPPLAMRPMKLPALEHAPLQDTRSGTEAKRHDVDVVPFSVSSQPVSFHHPMHWLLAETLKHLHKVQSIDALLPVLNEDDWLRLMEHPVRVAVKLAQIRCNVWVRNGFVIRSQAYHYRDSMWMRDIMYDQDLFLQQCGMAFTTPERFLATLLDRFELVDFLSGRSAQHNVYDAQQLVFMTEELFLLLTVLLNEVSVMAHWPIEAQVRHELIHYLALGPCTYSDLTKQIPERYTDHGCFDHELARVAHFRKPDGSADHGLYELRPAYLADVQPFFHHYSRNQREQAEQVLAEKRQQGCTLPLYQSSQLHVLANTPFSGLAHVFTSPVMADMLFYALSYAISQPEPPDTLMNVTLHLIAQGIEECGREFVANILMPERTSRDASSETNERAESAHEVPVHTPDPISATKGATEGATEGATAAASAASSPRTLVALLVQLSQHSQQAAAYKPKVTYILEKAAVWAPDTAGLVQHVQKPTEQPTDDDARRKAARARQTAILQKFSAQQQSLLAELEDELGSDDDDDTEQGYGPCILCQERLDSGSSFGTLVHVQHSRLVRTSVPRTSEALSDVLATPLNLDRVRAAPHDDIHSSHGSSRDRMRGQYTRTDERGSQLGYPAPAHVTGLVAVSCGHSMHVSCFHTYLQSTEQRHAFQVARNHPEDLSRFEYVCPLCKSLGNLLLPEPGVSSLGSQALWDTSHAIPSSPAQSLGHVQLSPAPLTEWVRSVNIAILKSTPADSAVLTDHQDMVHGTGCFVPWLVSGSAQPHNPDLGAGIFGADECHMLHRYTSVLQLLSDETAHSRLQERHATVLDALGSNNTAMYVPESLVAYTIAQLDIAQRGMPQPIAHSLSATQVRVVQMLLESLGASARLVAHHVHDAHMLQQGLYKRLLPQWASEPAVRSPIILRHAMGVLVEAAVLVPDQMRHVATLMFYVNLVQCVFGLAQPMMKPTKPASPVDSSDLDAALRIFPHARWLVTSIVSLVGYVRGNMTLGFDQLSDGELAKALCSYTLPFLRRAAILMRVVAGEQAVPVVDADSEYESLLASLQIIPPTEALPVHSQPNALLTMLVEGWTKHAYVHLAPLFRPLPIQQGPAQSVDSLVLEHPHIYELLPLPARPHDPPAADASPHVPSLRHVAAHIFPLPAMWRSAVRTVVLLLGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4H4</accession>
    <name>A8Q4H4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730160.1">
        <property type="nucleotide sequence ID" value="XM_001730108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4H4"/>
    <dbReference type="FunCoup" id="A8Q4H4">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4H4"/>
    <dbReference type="GeneID" id="5854467"/>
    <dbReference type="KEGG" id="mgl:MGL_2542"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2542"/>
    <dbReference type="InParanoid" id="A8Q4H4"/>
    <dbReference type="OMA" id="AYIPHFQ"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="4">
        <location>
            <begin position="878"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1060" mass="114821" checksum="4AF4EA82F7B881D2" modified="2008-01-15" version="1">MAQISGVGDKMASLADEVVQLIIPSLVEQIESPIEGLQTNALDVLNDVLVHAGTFVSSHAPLEQAVADILLSKLSSGRASLVRRGIQGLSFLSQVCRIHTYDAILERGLAGLQPPFLSEAVAVQLLGVLARETPQRLRPHKTKYTHGLISALERANQKEEADEFRESCLVSLQSLARMAGAEPECMKGALETALSMLQYDPNAMDAMDEDDIGDDLELDDDDMLDTFSDDDDLSWRVRRAASRLLGTLFEENPQEMVPSASRVTAALVERLKEREETVRLEALGALKSVLIAAPEAFRSHTSIVEALCTWRGAAAQVAALDALDKFVSSFGMALSQGENALNLALCAVEDETKTHSKGRCIAGLALLRQLCVCVPTVVLPHAVRVATALAESSQLSHHHTALEGLEASTQFLWHVGPRVPQQAELLCDAVCTRLERSDTDASVRDAALVALDAALCSTGAQLTDRLPRALALIYARLTHEVTRARCVQVVHDVMTCRSLQTCAPTKDFARQCLAPLSDLARQRDTATSSLRALHSVAVLLQNEAQPTLLNILSRELPAVNSPMLPPTLELAELAVQCDPSVAHTVVDNVLPGLLKQLSDVPPPALEALHSLLTSLASAEDSLAPALVTALEHAWELHCSDRAAQVPLVYAQCLGAAAAASDSISTVLARVQALLKEQSTTAQTLALYALGVLGQKGLLTGWPHAQHVFKTVLNLHLHGRAFALGGMILSNASFASPVIEKLAGGEADAARILCEALSLASETQTRDLAPMMWPYLQSAILAEHAPDACAECIARIVVVDTKRLGELAQLVQAPQVPMRVMGLVAVRTLLSLDRQNAADDEMNKYSGKFFERLGDPELPVRRAAMMVLHAAVNSRTTLMLKHASLVLPFLYDATVVREDLKRKVLMGPFTVIQDDGLDLRKNALETLFTFVDTCIDCLQLRDVMDCVLRALSDDDSVKLLGCLMLMRLADLEYMDLTPYLDAITPKLQAILTRKVRDNATKQEVEKASEITHAVLRVLTRLAPLAPLSPSFTELLAQTRASPHGEAWLRLMADRSTEGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4J3</accession>
    <name>A8Q4J3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730167.1">
        <property type="nucleotide sequence ID" value="XM_001730115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4J3"/>
    <dbReference type="FunCoup" id="A8Q4J3">
        <property type="interactions" value="644"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4J3"/>
    <dbReference type="GeneID" id="5854474"/>
    <dbReference type="KEGG" id="mgl:MGL_2549"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2549"/>
    <dbReference type="InParanoid" id="A8Q4J3"/>
    <dbReference type="OMA" id="WRAAQCA"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21377">
        <property type="entry name" value="CTWD_Cns1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="6">
        <location>
            <begin position="261"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="396" mass="44391" checksum="AE0513A33AD25B85" modified="2008-01-15" version="1">MANDIMTSSSAPVATAEPPKRPNYEEKMKELDTVPLFMRDLPKQETPNPALEALQTLAFDGPPNEAAENFKNQGNEYFRAKRYKEAAGFYQQGLQAEPEDAKLKETLHLNCAACHLELQNYGRALHEARAALIVNPKSVKALYRAARGFLALDRVADAKGCSDLALELDPSNPELVKLQERVSQRKERLDLLEAERAERKRRQGLENQALQMAFVSRGLWMKQSNDPPDNPTPAHFDHESLPPASSKDIPLVGALRPWKAPDPITTPVIFPVMMLYPQYNTSDLISEYHEDTPVGMHLDVMFPPESRGSLPWDTKGEYVSPNLSVIAKTRKGRLLRMGHKLSLRELLDQGAQLSENNDPKERDGIVLRDGIIDLYVLPKGSDAEKAWISTNKGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Q2</accession>
    <name>A8Q4Q2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Q2"/>
    <dbReference type="KEGG" id="mgl:MGL_2603"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2603"/>
    <dbReference type="InParanoid" id="A8Q4Q2"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="19" mass="1988" checksum="625387EA6C8E6256" modified="2008-01-15" version="1">MLGRLGLKNVNAPSSSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Q4</accession>
    <name>A8Q4Q4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730223.1">
        <property type="nucleotide sequence ID" value="XM_001730171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Q4"/>
    <dbReference type="STRING" id="425265.A8Q4Q4"/>
    <dbReference type="GeneID" id="5854528"/>
    <dbReference type="KEGG" id="mgl:MGL_2605"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2605"/>
    <dbReference type="InParanoid" id="A8Q4Q4"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="174" mass="18729" checksum="267D4F00DD65965B" modified="2008-01-15" version="1">MLVAVTQMTSGGIIRENLAIAQNLVRCAANAGAKLLIDDKGQIQARYRKMHLYDVQVQHGMSICESNTTIPGTELVPPVSTPFGRTGLLTCYDMRFPEVALSLRRSGAQILTFPSAFAVRTGAAHWSTLLQARAIDTQCWVVAAAQVGTHPGTTRTSDMPPFEAAFGLADIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4T0</accession>
    <name>A8Q4T0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730247.1">
        <property type="nucleotide sequence ID" value="XM_001730195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4T0"/>
    <dbReference type="STRING" id="425265.A8Q4T0"/>
    <dbReference type="GeneID" id="5854552"/>
    <dbReference type="KEGG" id="mgl:MGL_2629"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2629"/>
    <dbReference type="InParanoid" id="A8Q4T0"/>
    <dbReference type="OMA" id="HFTITHI"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="45"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="531" mass="59483" checksum="3DDD335D2CADA918" modified="2008-01-15" version="1">MTWSPQSLDPLRFFPPLTQPAPPLDTHASTSALQLTLSDKKRFYVGLSNPSIDCYFNSVVQSLASLVHLAQYLDDVTVMSRRWHVATPVTDALRSLLVLLNTPQSHRMTVAPRDLRRALQHRASHSQGIRTLLSAQQQQDAHELCVLLVEALDAELGTVQQARSDALRAACVGLQVLTAPSHIVHGRLRTQLGFDGDHSSNPFRGTLAQRTSCGQCGYMEAIRHFSFTDIDLVVPGAACTLEYCLSAWMQLEGIEWVCHRCSLLATMKRIELERIARDAQAIDHRQSARQLKKIRLLDAQLDRVAKVIRSGVHESELEASHALDGIVQERVLSTSATKQIMLAKAPRILLLHVNRSSFSLGQFGASKNHARVLFSERLNLAPFITGSSLSSHPMKRLSTSHTPTWYVLRAIVTHYGTHNYGHYVSYRRRPNGVWTRVSDENVQLCAWDDVQAQNPYLLMYERVDGYDDNGCSESVNDIGNPHGGDHGEPRIFHSAPRTMIPPLHKTHLQPRTLHRWDAYAFLSRNHATPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Z9</accession>
    <name>A8Q4Z9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcipressin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730302.1">
        <property type="nucleotide sequence ID" value="XM_001730250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Z9"/>
    <dbReference type="STRING" id="425265.A8Q4Z9"/>
    <dbReference type="GeneID" id="5854607"/>
    <dbReference type="KEGG" id="mgl:MGL_2684"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2684"/>
    <dbReference type="InParanoid" id="A8Q4Z9"/>
    <dbReference type="OMA" id="ACHATDE"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28289" checksum="D229E9B093CF4F0E" modified="2008-01-15" version="1">MFVHFPPTFFASENAVSLFLDVLHAYGHVVDWTPMPAFRQAMAVFEEVSEAQRIKQVLDRLLIPHDDDDDEGSSETSMLRVYYDHETPLVLLPSGEYVVARTLDGSTTFLEPPVPERDFLISPPGSPPVGWEQQVEGRPNTDTLAQDLIEALQKLSTTAETKPVLEHEHRSCHEPSGECDYSEQRRISMLLSPEDAVNDVPGVILHATDEPTACHATDEPSLIHRVKATNDSMLGSTLSSKSFKRPTPRPPMCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q524</accession>
    <name>A8Q524_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2703</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730321.1">
        <property type="nucleotide sequence ID" value="XM_001730269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q524"/>
    <dbReference type="FunCoup" id="A8Q524">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q524"/>
    <dbReference type="GeneID" id="5854626"/>
    <dbReference type="KEGG" id="mgl:MGL_2703"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2703"/>
    <dbReference type="InParanoid" id="A8Q524"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="32"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="175"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="37"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="346" mass="36235" checksum="D6F2DA4F896A02A5" modified="2008-01-15" version="1">MFARAALRTPAQAVRVPAASRLFSQTASANSKVAVLGASGGIGQPLSLLLKLNPNVTDLRLYDIRLAPGVAADLGHINTPSQCTGYAQENLEQALEGAEVIVIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAAKVSPKAHMLIISNPVNSTVPIVAEVFKRAGVYDPKRLFGVTALDIVRASTFLSGIAGSKPADTNVPVIGGHSGVTIVPLLSQAQQGSSVSPGEQYEKLVHRIQFGGDEVVKAKDGAGSATLSMAYAGAVFADALLRAMHGEKGVKQCAFVESPLFKDQVQFFASPVELGPNGVENIPALPQITAEEQKLLDNCLTDLAKNISKGVNWAAENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q552</accession>
    <name>A8Q552_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2725</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730343.1">
        <property type="nucleotide sequence ID" value="XM_001730291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q552"/>
    <dbReference type="GeneID" id="5854648"/>
    <dbReference type="KEGG" id="mgl:MGL_2725"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2725"/>
    <dbReference type="InParanoid" id="A8Q552"/>
    <dbReference type="OMA" id="YIGAEMP"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="2"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="437"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="489" mass="55525" checksum="BEAA7F02F18B3AD7" modified="2008-01-15" version="1">MGLTVLLGSDDLLAAFACGTAFAWDGWFQKQTADSNFSSIVDLIFNVATFIYIGAEMPWREFNDSAMNLSVGRLIGLSILVLILKRIPIVILCWKFIPDIKTFHEAIFTGYFGPMGVGAIFMCTYGRRMLPENVNIPPQTPNEVLSLTIQPIVFFFVLASVIVHGFTIPFFAFGKRAQVNLNRTLSIYPSTFPNSEPSWVHRIRRFNTNATAASAEPDQVPSSVVQAMQEGYERHKASGNVEPEENPDENMPKSKPFTKPEKSVGFGRVQTIDDVDDANVSEGDDWEGEDTVEMRRHRMRLEDEKRKEMFEGQDITDVPRNNDDHDLEKQAVMFSDDENNQEYPKMREWVEGNNLLVEVTERPLDEPETVVVPLTEEMREDLELKENPLRSALMMYEDKLAKHIGWEGKSKLFDLPLSQLRQHRVLSKLSEFTSHIRKERRNSVTGSRDLGSSSSIQQQQHPNSIRPNNHDSSSELEVVAVKPDGTILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q575</accession>
    <name>A8Q575_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730360.1">
        <property type="nucleotide sequence ID" value="XM_001730308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q575"/>
    <dbReference type="STRING" id="425265.A8Q575"/>
    <dbReference type="GeneID" id="5854665"/>
    <dbReference type="KEGG" id="mgl:MGL_2742"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2742"/>
    <dbReference type="InParanoid" id="A8Q575"/>
    <dbReference type="OMA" id="PEDQFTN"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="340" mass="38805" checksum="35C6F26B64780813" modified="2008-01-15" version="1">MFFYRNSVSGSIATVFGATGFLGRYLVSKLAKVGTQVVVPYRDEDEKRHLKLLGDLGQIVPLEWDIRNEQQIDECLRHSDTVFNLTGRNYATKNFSMRDVHVDGARRIAEIAAQAGVARFIHMSHLMADVDSESEYMRTKALGEDAVRKVFPSATIVRPSSIYGHEDRFLNKMASWPITWKLNNGQTVLRPVHSLDVAEALLVISQQDRLAMGETFSLYGPKAYTIRELLQIVENITYQKIVSPDVNIPRFMFSAIAKLGEKIAWWPMFNQDEVTRRFINEVPAPGTKSFADLDIAPDVLEDVAIMYLRRFRSHLRYEQPIENAHSGAVKLRKRPFRVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5B4</accession>
    <name>A8Q5B4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730389.1">
        <property type="nucleotide sequence ID" value="XM_001730337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5B4"/>
    <dbReference type="GeneID" id="5854694"/>
    <dbReference type="KEGG" id="mgl:MGL_2771"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2771"/>
    <dbReference type="InParanoid" id="A8Q5B4"/>
    <dbReference type="OMA" id="NTSICSH"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46588" checksum="FC8940E333E6CBA5" modified="2008-01-15" version="1">MRSVDVSHTGDPIEEASNRQDDVELRLLDEENHRDTEAEKHHPLSSEEEEDSHHLVRQVVPETDNPLLPSLTLRAILLGGLFTVLGAGMSQLFFYKSNAPSFSSYFVILVTLPLGRWLARLLPERDVSLFGWRFPLNPGPFSVKEHVLIAVTVSSGATSAYASDIINIQELFFGEHMSALPSMTLLITTQIIGFGFAGLVYNLLVRPPSMIFPGALVTVSLFNTLHDDESILTQKRMRFFLITFVAIFLYQFIPTTLFPTLSSIAVLCYVHRSRIAQILSSGYKGFGILNLSFDWNVLGTSGPLFTPWWAALNFYGGLIIMMYVIMPILYFSNFWNAKLFPSVLSSALYNTTYQTFDVNAVLRYDNTLDESAWNEKKPMLLTPFFAISYGISFAMLTSTIVHVLLWHGKEITKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5R8</accession>
    <name>A8Q5R8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_2809</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729823.1">
        <property type="nucleotide sequence ID" value="XM_001729771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5R8"/>
    <dbReference type="FunCoup" id="A8Q5R8">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5R8"/>
    <dbReference type="GeneID" id="5854130"/>
    <dbReference type="KEGG" id="mgl:MGL_2809"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2809"/>
    <dbReference type="InParanoid" id="A8Q5R8"/>
    <dbReference type="OMA" id="FGCQALV"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="60"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="241"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP42609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="402" mass="45686" checksum="869334C59777E74D" modified="2008-01-15" version="1">MSMPEDTPAATDMQLTDGEIQSNWEEVYDNFDNMGLSPELLRGVFAYGFERPSAIQARAIVPVIKGHDVIAQAQSGTGKTATFSVAILQRIDPNLKAVQALVLAPTRELAQQIQNVVVALGDYMNIQCHACIGGTNVREDMARLSDGAQVVVGTPGRVYDMINRRAFRTDHLKMFCLDEADEMLSRGFKDQMYEVFQLLPQDTQVVLLSATMPEDVLAVTKKFMRDPVRILVKRDELTLEGIKQFYIAVEKEEWKFETLTDLYETVTITQAVIFCNTRRKVDWLTEQLHAMEFTVSAMHGDMDQQQREVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTHDDVRMMRDIEQFYNTQVEEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5Z5</accession>
    <name>A8Q5Z5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729848.1">
        <property type="nucleotide sequence ID" value="XM_001729796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5Z5"/>
    <dbReference type="FunCoup" id="A8Q5Z5">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5Z5"/>
    <dbReference type="GeneID" id="5854155"/>
    <dbReference type="KEGG" id="mgl:MGL_2834"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2834"/>
    <dbReference type="InParanoid" id="A8Q5Z5"/>
    <dbReference type="OMA" id="YTEWADG"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0138">CF(0)</keyword>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="245" mass="26729" checksum="49F089E7844AAA1B" modified="2008-01-15" version="1">MVFRIVSRSAQAATRHSLAASVPRPAAVLPAVMKTPARFYSDKPSPEAKASSIIDSLPGNSLISKTTWVTLGAGLTAFGVSNELYVANDETVILAGFLIFATLLGRSVSTPYRDWADATIAKISGILNEARSGHTKAIQTRIDAVDEKKDVVDATKGLYALAKETVQAEKEAFELKQKTQLAAEVKTVLDSWVRFEAQEREAEQRLLTETVIEKVAQTIRDDKTQKQILDSAVAEIEQLVKSKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q601</accession>
    <name>A8Q601_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729850.1">
        <property type="nucleotide sequence ID" value="XM_001729798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q601"/>
    <dbReference type="FunCoup" id="A8Q601">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q601"/>
    <dbReference type="GeneID" id="5854157"/>
    <dbReference type="KEGG" id="mgl:MGL_2836"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2836"/>
    <dbReference type="InParanoid" id="A8Q601"/>
    <dbReference type="OMA" id="PRDKTIC"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="243"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="620"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="74071" checksum="9AE4BC3AE7F87B02" modified="2008-01-15" version="1">MVHAQSEHNAHDPTEDNTDATDATLNAERREESSRHKTDGRHAPSTATSDMAGMLRHKEVRQPTETVPIDQQADLQENHADGENGRTNDDTTEDSQRQEAKGKGKERAISAENGVSDDTSDMHAKSTPRRPQLPAEKPFDFNRFLEQMKHRSAVPVNEYVRSFFRGFTRRPYKPDEQVKLIFDFLDFIAKRMMEAAVWADLPPNEFDQATEAMEKLVMNRLYTYTFSPAIAMEGRWSVQTDDLEHDRKLSERIQLFAWVREEHLDVKRGQHSERFYNFAAQELSKINHYKAPRDKTICILNCCKVIFGLIRHLGSDESADSFMPLLILVVIRANPPNLISNLEYIQRFRSPQRRSSESEYYLSSLAGAITFIERMDHTTLSRITQTELDANVQREAAKMEAEAAEKSESTARPFSLAASVAAVSLADDTRAFFQRTGEAARLGFNRLFTERSDMVQQDARTSELRPLPSASSSARPVVPPVTPAGTAPQPHLKPARGVAPNAPLRVAGADPMHDDSPRSVTTPHTQVSSATRVPRWRSGLMPRFDDDDERDVAGAYDDDDGNDDDADRTGSGLRDSPSRHVAAAIRYADGDGTLDDVDDERGDTERHAQGDDADIDASVDVAAAIQTLQSIFPQADTSVLQLVLEECGYNVETSIDRLLEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q616</accession>
    <name>A8Q616_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729855.1">
        <property type="nucleotide sequence ID" value="XM_001729803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q616"/>
    <dbReference type="FunCoup" id="A8Q616">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q616"/>
    <dbReference type="GeneID" id="5854162"/>
    <dbReference type="KEGG" id="mgl:MGL_2841"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2841"/>
    <dbReference type="InParanoid" id="A8Q616"/>
    <dbReference type="OMA" id="VKQMQVW"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="117"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="518" mass="56010" checksum="E6E8FD6F3F097FA4" modified="2008-01-15" version="1">MHVTMIDANKVHHFGDWMSRMKEHTRPASDQHDGIPWENRVISMNLDNLSWMQDIGAYPYLDTSRMRTVERIRVWDGLTGAAAEFGSGQQALSSMVELSNLQQALYRFVQAHLPSSRVTLDILDQTKVQGIEADTSEDWPRVSVANAAGESTTIRTRLLVGADGNNSPVRKFAGIESFGWPYGCKGLVATLRSGLHTRSAEPIVDTMAWQRFLPTGTLACLPLSPTTATIVWALPPELSDPLVAMHRSAPVREDGTSSVLATLVSAGFRLPWNLLEPLLYEAPNIEPRVFEQRVLETMKSYEQAAGAQAPSAFSSAVPPWGDAVDARSVASFPLQVKHAGCYLGSSLNQQLGQSLAPSVLLNSVLTTLGLTPGGAARGGGQARTVLVGDAAHSTHPLAGQGLNLGIQDVRALCATLEDACAHGMDIGTHSALAGYERARYLPNQIMLSLTDHLHWLFATRPASAYTSPMGPLHKAVREQALKALVWARSTGLDIVNELGPLKRLLENGAGSIRTPKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7C6</accession>
    <name>A8Q7C6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729779.1">
        <property type="nucleotide sequence ID" value="XM_001729727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7C6"/>
    <dbReference type="STRING" id="425265.A8Q7C6"/>
    <dbReference type="GeneID" id="5854085"/>
    <dbReference type="KEGG" id="mgl:MGL_3323"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3323"/>
    <dbReference type="InParanoid" id="A8Q7C6"/>
    <dbReference type="OMA" id="FQWTRSE"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="343" mass="37885" checksum="B5F5BE74283E8686" modified="2008-01-15" version="1">MSASGEDDMGVEATNTADGTCDMDVQKDATTESAEEDMDDFGDFEEGDAPSATYEREAHVDSNVTKHTSTSHVSSTLKQLPLGIDSNDISMREAIRELLPREFTNVHASMSDGSASDVVEEGMRQVEGLSQVLVSEQSRSMFRELDSKDMPSAPLDWRRSHTRRQYLISLGVPINLDEVLGNGPTKEALPPLQLNLMTSDHDSSSLSVPARPGAPKVSSKESWGDHRRRQIGLHEPSLPIGRIEKLLQLSEDDIKLLTLPELRELFREMESLSKRMGDALQYHLMIRETFSTDSEVYHGMIRDLVAGASNKVAARAKQEKRGFMGGRGSKNEDISRPGTPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7K8</accession>
    <name>A8Q7K8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729537.1">
        <property type="nucleotide sequence ID" value="XM_001729485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7K8"/>
    <dbReference type="STRING" id="425265.A8Q7K8"/>
    <dbReference type="GeneID" id="5853843"/>
    <dbReference type="KEGG" id="mgl:MGL_3081"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3081"/>
    <dbReference type="InParanoid" id="A8Q7K8"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13622" checksum="24375B858E90A6EA" modified="2008-01-15" version="1">MTHQGESISHGGAIANDSRHTHGGNTRLREQSPHRPVRDEHIRERSRSPRHDEARPARLAAEPIFERSGLLAKESNSVNGIALKYHEPPEAKKPRHPWRLFVFKDGKEIGTLAKVVLTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7T3</accession>
    <name>A8Q7T3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar membrane-associated protein Iml1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729569.1">
        <property type="nucleotide sequence ID" value="XM_001729517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7T3"/>
    <dbReference type="STRING" id="425265.A8Q7T3"/>
    <dbReference type="GeneID" id="5853875"/>
    <dbReference type="KEGG" id="mgl:MGL_3113"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3113"/>
    <dbReference type="InParanoid" id="A8Q7T3"/>
    <dbReference type="OMA" id="NTCAYVT"/>
    <dbReference type="OrthoDB" id="3217084at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="421" mass="47311" checksum="6975A1E3DD552B47" modified="2008-01-15" version="1">MELYFKDQYMGRADMWRLSVSRIETCVYVGQCITLPTGLRAKVGRLFVHEHSVMSGYMDASTKSIFRSESARCSLFLQMSSEMWEFDESGELYYEKVLHGFLPDLLRKWKVIGTNHVVSVILFTRVLYDASECEHLAGRPVLRTASGQLYIDYYKVIVDLDSSTDWTVTMRALKEEFFRFQHDVLLQPRWAAGGSVVPAAMPRDDADGADLEDSAVGGRVLLGRIARAYEGNLLEAVNLELNSADKHYIDRDLTRTGFSIIVLTPGTGHFYADKALLRLTTQRMFDRAVSMDLVCLTQMPLHMVPVFHYESTVQREPRFSAPRSPPQVHLGQQSDPLFQDSGLVGPKRTCHSMPFWINCSFYNIEQDRLHWKSRFVPPLSHGRHAHGGAVGLSAPETCSAVPLAATCAGPQCSSSTNSRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7Y8</accession>
    <name>A8Q7Y8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGT1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729617.1">
        <property type="nucleotide sequence ID" value="XM_001729565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7Y8"/>
    <dbReference type="STRING" id="425265.A8Q7Y8"/>
    <dbReference type="GeneID" id="5853923"/>
    <dbReference type="KEGG" id="mgl:MGL_3161"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3161"/>
    <dbReference type="InParanoid" id="A8Q7Y8"/>
    <dbReference type="OMA" id="AHKMSRF"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="96507" checksum="634199A2F2CB9F39" modified="2008-01-15" version="1">MDQEKQGPWQEEGIGALGPMPDDDAGESSSHFVAHVVLAEDADVAAMGLLLEQHLQRICSLPPPEGVNGYIWDREPPMVLQVPEGTEKALEVSMRVQECVDDEWFLTYVLREWTKTYTDVCIRVNDEDGEFLLIEAADALPSWAQPDTTQNRVWIYQAQLHLIPIDASSRDTSLSVSEAVRLVRDPHCATQAPSLVQDKAFARVDAYPAAALTHHHTTLAFLPPNAAKVFATYPQSTAEAVHALESRDAVSVRSLRHLPTPLRVQACNEVDDDAATVPKPPATDAVLVRVTLTRHLYARLSYDRFFAPASLGRRWQRFVELYRLAKRGEASMAEKNDLALWGRWCDTGAKLVAGLAMWLDTLGRRQMTQMQDALSSSSSSSPTMAPHRYEQFIAALTKFGFFGNELCGSAAWKEREAQAAATAARLGSVSPGSAESSRSSSGVSYRQILSAMQAQDPEKELWQALPLTSQSIPSLQMHEDSEAWLSMAPQDIEALLSGRTQDEAEDASMDRFQSFMSKMQSFLHRQGDVEGALFDDDANFDTLEDGDEAGADADANDSSDSEAERKARMDALVEPLAPGEWGAESAKAHDGSLASDDKAATTVQAHSKSMTHLQPALHPRGEKRTNRLAGLSRLERFDGDSDSDEASLPDDDHDAAEDRAERHRALEMIDDDEPEDDEEDAPIEQDMGDFFEFTRRTLGLSDSQYAEILEERRNRGAFVPSAACPDTWAEKVHDSKSTDSTMSETAALMPTTTTKPSLASLDAALDAMEQELQERTRPSTSTSSGRAMLSDPMEEDEDADDLNEEETELLHHLLASGMSLPESLQRFATEHDVHNADVEMLGHFLESFKAQNGHPGPVGTLSQRLGVGSLPRDTDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q865</accession>
    <name>A8Q865_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729668.1">
        <property type="nucleotide sequence ID" value="XM_001729616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q865"/>
    <dbReference type="STRING" id="425265.A8Q865"/>
    <dbReference type="GeneID" id="5853974"/>
    <dbReference type="KEGG" id="mgl:MGL_3212"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3212"/>
    <dbReference type="InParanoid" id="A8Q865"/>
    <dbReference type="OMA" id="MSHELAY"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="109"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="301" mass="32220" checksum="0C0BCD712F886697" modified="2008-01-15" version="1">MRNTKALEPLDVDDHVEKVSVVSSSVPTSGWSARGHIHAKVTRHASSPVTTDLSDSIDTDNTWPAQEVASVSHQPGSAWRIQTPALRRSVLGLYAPMSRSQLSKYMIPGAILAVLCGGVPISMTYVLGRAFSALGQYVPEPDASASLLDKMRNDALGLLGLAIAALVLRSLDTYAWLLLGENGAQAWREWMLSAIVEKEVSWFELGMGLESGTGAAGLMALYASDTDDVRLAMGIHVGGILRHISTVLVATGFALSRHWALTLVIYATLPAVIFIMVVGDRMAAPLEAATRCRARELSTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q870</accession>
    <name>A8Q870_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729671.1">
        <property type="nucleotide sequence ID" value="XM_001729619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q870"/>
    <dbReference type="STRING" id="425265.A8Q870"/>
    <dbReference type="GeneID" id="5853977"/>
    <dbReference type="KEGG" id="mgl:MGL_3215"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3215"/>
    <dbReference type="InParanoid" id="A8Q870"/>
    <dbReference type="OMA" id="NDRGERM"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000545">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="291" mass="31848" checksum="4A8CB6323594C3C3" modified="2008-01-15" version="1">MNPRQTVFDAKRLIGRRFDDPDVKKDMQSWPFTVADKDGSPVIEVEYLGEKKQFAPQEISAMVLLKMKEIAEAKIGKEVKKAVVTVPAYFNDSQRLATKDAGTIAGLDVLRIINEPTAAAIAYGLDSKSSQEKNVLIFDLGGGTFDVSLLNITGGVFAVKATAGDTHLGGEDFDNTLLEHFKKDFERKNKVDMTGDARALRRLRSACERAKRTLSSVTQTTVEVDSLFQGIDFQANITRARFEEINAAAFKGTLDPVSKVLKDSKIPADKVDDIVLVGGSDTYPQDPVACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8J3</accession>
    <name>A8Q8J3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729737.1">
        <property type="nucleotide sequence ID" value="XM_001729685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8J3"/>
    <dbReference type="STRING" id="425265.A8Q8J3"/>
    <dbReference type="GeneID" id="5854043"/>
    <dbReference type="KEGG" id="mgl:MGL_3281"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3281"/>
    <dbReference type="InParanoid" id="A8Q8J3"/>
    <dbReference type="OMA" id="GWEQAMW"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725509" evidence="2">
        <location>
            <begin position="21"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="656" mass="74061" checksum="E469771C7728EFA6" modified="2008-01-15" version="1">MRAAWLWCVAHAAFCAYANAAHKVAASSLEVAQLPSEKLVPFFMQHYSQPQEALDDALILLRSLIGEPSIEFDSSKDQAFPTWIERMTSRLESIGLPGMSQLRQSVHRWIRRQSAMFPRGDYNTYTSTLRVFLARFVELLVEKPTYKQRGAHTYYDMPLEPLWPNWDFDHVKAYHASQRQDTLPVINGWEQAMWGPFIGPVREAPHALMHEIVHNYTSSYTKSALVDLARANPSPDVDFHTASASLRAVRTHAIRLLEWVAYPPDDDTSVDAMLRASFAFFNETSRAQADALWILGEHYFWGTHGSAPNMTKAYQAYERLSKTGNATAHSRLGYMHSSPFLTKVYGFKGSDTDAIVHLALATQEGDWLASNAMGYRLMHGIGTSANCTESLVIFDHLARRSHEVFEQGPPGGRTLPYSKVRLSDRMRLSGPSHQLASGQGFKAFFSVVPFSYYRTQAIIKKDMNAMFDQAALDELMDQYSYLAHEDPIKQFEYASALYFGSIYGYRESLGAIRPNPELAAHHALSLATSRWPIYIKLAHIDDELYRDGYPDKMLAIMSQSSAHAYAARNAAVLLGVMYLRGEGVLQDFKKAKVWLTRAAHEQQPLAMSYLGMMYANGYGGLTPNMSRAWNLFKNSHEKSTLSLLEIAKQHISTYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8L1</accession>
    <name>A8Q8L1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Asn/Gln amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729746.1">
        <property type="nucleotide sequence ID" value="XM_001729694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8L1"/>
    <dbReference type="FunCoup" id="A8Q8L1">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8L1"/>
    <dbReference type="GeneID" id="5854052"/>
    <dbReference type="KEGG" id="mgl:MGL_3290"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3290"/>
    <dbReference type="InParanoid" id="A8Q8L1"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="7">
        <location>
            <begin position="323"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="485" mass="54487" checksum="9B3FBF4FCAC7EE14" modified="2008-01-15" version="1">MMWAWRSVRALHTSLRRTKGTKALLPTGWEAVIGIECHAQLLAPTKLFSHLPAGYQITQKRKPFAHSGTVSIRFEDGYLSTPNDAVDVPILQLQLEQDTGKSMYAATDADSHVSLIDYNRAGVALVEIVSAPVLRTPEQAGAYVRKLRQLLRHVGASDGNMNEGSLRCDVNVSIHRINEPFGTRCEIKNLNSVKFMMHAIDYEIRRQFRELSQGRIIEPSTLGFNEATGETYVQRQKEEMLDYRFMPEPNVAPLEISPERIEALNSSLPEMPDARHARLREQYGLSIRDVNVLTRLNAEDDASEIAVLGPEHAGRTSHPNAVDYFEALVHFGCEPQVAANWTIHLLPKYLGQAQLTFSLNPVGPAALAELLHILEEQVITQSTAQSLLREFVLNQSIPQRDGYLCIREVIKERGLLRMQDTELLPLCKEIVQACPEEVEAIRRGKNKVIMRLVGETLRRAKGRADPEHVQRLLTELTSVETASTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8S3</accession>
    <name>A8Q8S3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729301.1">
        <property type="nucleotide sequence ID" value="XM_001729249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8S3"/>
    <dbReference type="FunCoup" id="A8Q8S3">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8S3"/>
    <dbReference type="GeneID" id="5853614"/>
    <dbReference type="KEGG" id="mgl:MGL_3336"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3336"/>
    <dbReference type="InParanoid" id="A8Q8S3"/>
    <dbReference type="OMA" id="WRILFVY"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="60"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="559" mass="61224" checksum="DD34FDD2B01A8CCD" modified="2008-01-15" version="1">MSIIAEEVSDTKPPPALSSFASVHLPESMQSSKPLHSDVQSDALQIDPKSGVKRGLKNRHLSMMALAGIIGPGLLVGAGGALAKGGPASIIIGFGVVGIIAYSVMQSLGELTTIFPDGGAFLQLADRMVDRAFGFVVGWNYFIVWAAVLANEYNVITSVLVFWSDKVPQWGYFLIFWFAFLAFQMLGVESFGEAEFWLALVKILGLVAYFIFSIVYVSGGVNGDAVGFRYWNNPGAFGEHGFRGVASVFIFCATFYAGIESVSVAATETRNPQKAVPSAIRQVVWRILFVYLGSAFFFGLTCPANAPGLVAQDGALQSPMTIAIQHAGWTGGVHLINSFILVTCLSAVNSSIYIGSRTVLYMAQNKKAFKFLGYTNSRGVPVFAVILINAVGAISMMNVSTGASKAYSYIVNLSGVSTFIVWAAISFMHLRFRRAMRVQNRSLDELPFKSLLFPWIAIFGFVLSVFLALVQGWTTFSPFDTGDFVDAYILIPVSLVGYIIYKFVYRTRFWRAREIDLDIGRRQDLDSFSSIISFETQDDLNQEVAQEDANYSVEKQQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9F9</accession>
    <name>A8Q9F9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729439.1">
        <property type="nucleotide sequence ID" value="XM_001729387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9F9"/>
    <dbReference type="FunCoup" id="A8Q9F9">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9F9"/>
    <dbReference type="GeneID" id="5853746"/>
    <dbReference type="KEGG" id="mgl:MGL_3474"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3474"/>
    <dbReference type="InParanoid" id="A8Q9F9"/>
    <dbReference type="OMA" id="LHIEYSC"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13717" checksum="7094FC7F748C0668" modified="2008-01-15" version="1">MVLLTTSDNEHFTVDRDVAERSVLIKQMIEDIGETDQPIPLPNVSSSVLTKVLEYCSHHRHDPPVPADDTDEMRRRATDISEWDAKFIQVDQEMLFEIILAANYLDIKSLLDIGCKTVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9N5</accession>
    <name>A8Q9N5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinetochore protein Nuf2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3518</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729483.1">
        <property type="nucleotide sequence ID" value="XM_001729431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9N5"/>
    <dbReference type="FunCoup" id="A8Q9N5">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9N5"/>
    <dbReference type="GeneID" id="5853790"/>
    <dbReference type="KEGG" id="mgl:MGL_3518"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3518"/>
    <dbReference type="InParanoid" id="A8Q9N5"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="104"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="277" mass="32192" checksum="EA768485FC5F52CD" modified="2008-01-15" version="1">MVQKVYLAFLDTLAGTMQEMLEKQRDSLCEPLECKEIYEDGVAWLLFFREVRTMMEAATVHDFHLQDLTRPTPKRFKRHMSALVNFFRFRSDRLAEFDELVLETEDLENRRIELEDGIEQARSAIEKIVSQRKSDEPRVKQLQEENLAHSDRLLDMKKEQSRLLAEVDALKGEKTDAIQKQTDVQYQLQIVSTELTKLQARIVTRPDDIKRDVRDMQVQVQGERVSLGESERKARELSAKMDVLTQLDADIAASMAHIHTSTRRKCIGLSNWIAKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9R6</accession>
    <name>A8Q9R6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729510.1">
        <property type="nucleotide sequence ID" value="XM_001729458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9R6"/>
    <dbReference type="STRING" id="425265.A8Q9R6"/>
    <dbReference type="GeneID" id="5853817"/>
    <dbReference type="KEGG" id="mgl:MGL_3545"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3545"/>
    <dbReference type="InParanoid" id="A8Q9R6"/>
    <dbReference type="OMA" id="INLYSHW"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF2">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="124"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="447" mass="49472" checksum="2206510F2F86064B" modified="2008-01-15" version="1">MGSKTDLLWSTITLPCGAVIPNRFTKAPMEEMLSTLGGGKPNDDVYRLYKAWADGGWGLIITGNVAVDRRYIGMFFDMVVPDAGNEKVDAEYLTEFIKYARATKGFDVGDARADSSPPDGRRPLAVVQLVHCGRQSMRCAYRMPWVPAVAPSVVPVQTFRDKRSWFDAIMFGTPHALTFDEVQDVIHRFIRAAVFMEKAGFDGIELHAAHGYLLSSFLSPKTNLRDDEYGGDAERRFRIIREIIEGIREKVSPKFVVGIKLNSSDYIHGGQTEDDALQNVKWLAETNMVDFVEVSGGSYESPAFAESASERTKQREGFFVGFAQRAHSILPSGCRMCIIVTGGFQTRAGIYDTLASGVADSVGIGRPACLEPHLPRKLMDSTVSDEDAKAVVWKPPAPPVFIPKLPLAGFGWATMWHSAQLHLIAHGDPTDPHASMGSFFYNLHFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA41</accession>
    <name>A8QA41_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit RPN1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729133.1">
        <property type="nucleotide sequence ID" value="XM_001729081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA41"/>
    <dbReference type="STRING" id="425265.A8QA41"/>
    <dbReference type="GeneID" id="5853439"/>
    <dbReference type="KEGG" id="mgl:MGL_3600"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3600"/>
    <dbReference type="InParanoid" id="A8QA41"/>
    <dbReference type="OrthoDB" id="3005355at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="93" mass="10248" checksum="AE18C9F1F9467D65" modified="2008-01-15" version="1">MFWLTAAMRPRFLITLDESLEILPVSVRVGKAVDVVGQAGKPRTISGFQTHTTPVRLGSRERGVIATEEYLSYTPIMEGFAVLRKNPGSEPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAA2</accession>
    <name>A8QAA2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3661</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729194.1">
        <property type="nucleotide sequence ID" value="XM_001729142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAA2"/>
    <dbReference type="FunCoup" id="A8QAA2">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAA2"/>
    <dbReference type="GeneID" id="5853500"/>
    <dbReference type="KEGG" id="mgl:MGL_3661"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3661"/>
    <dbReference type="InParanoid" id="A8QAA2"/>
    <dbReference type="OMA" id="FAVHWNL"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="331" mass="36042" checksum="752C9AF91A68A516" modified="2008-01-15" version="1">MHRPGAASASKRYPTPGYAGYNVAWSPFFPDRLAVASSANYGLVGNGRLHLFGSTPAQVKVFDTQDGIFDVAWSEVHENQIVSACGDGSIKLWDATLDDHPIRNWQEHAREVFSIDWNNVQKDFFASGSWDGSVKIWTPERPTSVQTIPAHSACVYRCAWSPHNPNLLATASGDGTASVFDLRGGARPVATMSAGGEVLALDWNKYKPMTLATGGTDRAIKVWEAHTAAPSSGGLVPERCVLLGHQYAVRDVAWSPHKNSVIASASYDMTTRVWSMDDASVPAQIPMVNTPRQVYSGHREFVVGVAWSLFEPGVLASASWDMETHVWPAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAE9</accession>
    <name>A8QAE9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729241.1">
        <property type="nucleotide sequence ID" value="XM_001729189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAE9"/>
    <dbReference type="STRING" id="425265.A8QAE9"/>
    <dbReference type="GeneID" id="5853547"/>
    <dbReference type="KEGG" id="mgl:MGL_3708"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3708"/>
    <dbReference type="InParanoid" id="A8QAE9"/>
    <dbReference type="OMA" id="MSASSWH"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="332" mass="33913" checksum="9939BACB72C15691" modified="2008-01-15" version="1">MQFRDAIQYDSADRLDRGDTSRDDIDAMPLPGGFPSQSDGTSKIGTRAPSAMTGPGTKAAVPASREQQVPMSASSWHSPASVPKGKPGMPVQVIDLPPPEPRSPNANAAAMPAADVMASSIPPSSASTVVLPSTSEPQTPNVNMSGPAQDDFESAFSHMGLANVVHKSSGQTQPAQVAAGTPPSAAAVPAGTSSPHGVMPAYLQTSSQVVAPRARSASGAAAGGTPGLSSVSTTTAVPAMSASMPQTGASTPALATAPRDAFDDHFSPTKPLSPPQPASDRAPSPAMPGDIGPVRQLCQMGFSRSSVVKALERSNYRTERALERLLAMQSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAH3</accession>
    <name>A8QAH3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729265.1">
        <property type="nucleotide sequence ID" value="XM_001729213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAH3"/>
    <dbReference type="FunCoup" id="A8QAH3">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAH3"/>
    <dbReference type="GeneID" id="5853571"/>
    <dbReference type="KEGG" id="mgl:MGL_3732"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3732"/>
    <dbReference type="InParanoid" id="A8QAH3"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="298" mass="33711" checksum="41FE6BE339B60297" modified="2008-01-15" version="1">MRFYEKPLPDTDEIVMCQVRQIAEMGAYVNLLEYDNAEGMILLSELSRRRIRSIQKLIRVGRNEVVVVLRVDKEKGYIDLSKRRVSPEDVIKCEERYSKSRAVNSIVTHVAHKLDYPLEQLYEKVVWPLDRTYGHSYDAFKLSVTESGKVFEGIEIEEHALRELQANIARRLTPQPVKIRADVEVSCFGYEGIDAVKQALRAGEAVSTEAIPIKIKLVAPPLYVLVTHSTDKAGGIALMEHALEKITETIEKSDGKINIKMKPKAVSAVEDEELAQLMARVERENTEVQGDDDSGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAJ3</accession>
    <name>A8QAJ3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prenylcysteine lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729285.1">
        <property type="nucleotide sequence ID" value="XM_001729233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAJ3"/>
    <dbReference type="GeneID" id="5853591"/>
    <dbReference type="KEGG" id="mgl:MGL_3752"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3752"/>
    <dbReference type="InParanoid" id="A8QAJ3"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prenylcysteine lyase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="172" mass="18817" checksum="DFBE7C12583704DA" modified="2008-01-15" version="1">MINGVTRANYAQQVNQVHPLVSMVAMGAVNQFSIQGGNAQISKRFLEQSGASIRTGLRGDVTGLLHLRPSSSTSPSHAQWWVGTRDGHGEIFDAVIVATPWHDSRITLLDTDRSVPMYEMQKVHVTIVVTDASQPSHDYFHYGPSFKVPLTIVTTPAPDRSAPEVCMLHDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAU3</accession>
    <name>A8QAU3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729043.1">
        <property type="nucleotide sequence ID" value="XM_001728991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAU3"/>
    <dbReference type="FunCoup" id="A8QAU3">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAU3"/>
    <dbReference type="GeneID" id="5853350"/>
    <dbReference type="KEGG" id="mgl:MGL_3831"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3831"/>
    <dbReference type="InParanoid" id="A8QAU3"/>
    <dbReference type="OMA" id="ITYDSHA"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="294"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="617"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="71928" checksum="D9FD8D76649BF6FF" modified="2008-01-15" version="1">MLFPEEDAAAVKQWLIRELEPLCDADPDVLADYVLALFKNDTGEDELVAMLNEQLVDFLEGNTESFVRKAVDTLKNRSYTAGAGQTRKREDVEDIEVEEEHDDQPSKRQAYDAHDAQEPHDVQNSNNANDEQQTATSQGEGGESHAHVQSRPRRSPRVPKGWCRDYHTLGFCSRGANCKFLHSDDSIMGTMPQVPAPPPPFAMPAALPFMPPFPVGPDGSMPPDMMGMMPMPEHFAQMMQQMQQMAGTNGMMMGGRGGGMSRGSARRGSRGRGGSTRGGLPSSAPHAPVARSQDTIVIENIPSENLELVHVNDYFKRFGTITNIEVDKPNKKALVTYATPAEADQAHKSPDVIFGNRFVKVYFQRLERPPPSKPNYMNDKGSNVYLAPELRSATSATMTPADEEKHRLLELRKKRQTLVHMQLAEQKALLQKLENKDLTPQGRKSIMTMLEKLSAEIKGATEMLKKDIQSSNDMGSASTTEELQAKLAQLKAEAASLGLDTKGHPTSMAYRSAYRGRGSSSMPSFRGRGRGSTMMMNRSMTLDNRTTKVGISGLPAGYDASKLQEHVQQFGDINSMEYNDDQVIVTYKNRASSERAMRAGGSIPDVGNASLAWVEAPVAPTPPSLDNNASGTPTDTAPVAGVELDEGSERENWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAZ6</accession>
    <name>A8QAZ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exportin-1/Importin-beta-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729071.1">
        <property type="nucleotide sequence ID" value="XM_001729019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAZ6"/>
    <dbReference type="STRING" id="425265.A8QAZ6"/>
    <dbReference type="GeneID" id="5853378"/>
    <dbReference type="KEGG" id="mgl:MGL_3859"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3859"/>
    <dbReference type="InParanoid" id="A8QAZ6"/>
    <dbReference type="OrthoDB" id="5548448at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="85062" checksum="25DCFA69A0117032" modified="2008-01-15" version="1">MWQLCFCIPEIPTLLGYVARIAVVAMIRTSTMVAPALAARSQDLSHVCASHANVTTRAVHEAMLHVASYLPWDVHASTTWPAQRVALLDELNQVLHVLAAQLNTLDTERVALLQRLTHVYTQLMHGQSGCVLIQGGIVGANVLLDSLVRVTKTCFQVAFELVPRMRDAEDPITATSASEAAVDEVLSLWRSLLITLPPPDAAYTHPYVRDHVVLPYQAGRLHAAMLTAESDWDDFVAAENTSDADLYDEHLTLYAALARTCVYQAVQQLVASKPAVSDRGHISPAIWEQWHWLALMTGHLIADDSASEVALVPEGIQASCPEAQDQIHALLQDFMSLLAYLVSNGPNSSTPCSPQALISTLWLTARWIPVYLLRESPSRVEAPFAGSMGERFLDELVPCLRTALVAWRSDSDVIVAISLVWEALARSSGAMQIWLAKEPVFALVKDTLATLELLPDAAQPFILRALVRCVDATRDGHALAAQVRGMYYPLIMHAAQARFDSAAHASPVSLSSALSLWHALVDAADPSTSGAVHIHILSQLPAMVTSVEQHLANTDVQVSAGRATLALLRALPELQNTSTLLAGSAQHVLELLRAMLTSLTDQPRVSGLDATFEDLLVLYLSLLEELVRACASSDAAEANAPHADDLRLLCLGAFGAVMPMLKRDVLTIPSVAEAFAQLVHVLLIMARSALYSSTHGACPFLEGMTASFDLLDMGMHSILPQNVQSNTVMTLMNPLQMVLRAAVLHWLALLTHLPRALLVVSRRALAMYPRYCHAYRPARVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB10</accession>
    <name>A8QB10_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3866</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729078.1">
        <property type="nucleotide sequence ID" value="XM_001729026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB10"/>
    <dbReference type="STRING" id="425265.A8QB10"/>
    <dbReference type="GeneID" id="5853385"/>
    <dbReference type="KEGG" id="mgl:MGL_3866"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3866"/>
    <dbReference type="InParanoid" id="A8QB10"/>
    <dbReference type="OMA" id="VWVPDSL"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="171"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="416"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="75131" checksum="A8DBCED8B8A32682" modified="2008-01-15" version="1">MVSSSQKSLKETYQAETKVDWDPVHDAIGDLLVPIAPFLKMYSLFMQNFSNSMQCIENEQRSNERFRSFLREATKNFDGASSRGTLLGLEAQLLSIVQRVPRYRLLLHALLQNTPLEHKDHPWLSETYAVVDHIATFVNEHVRQHELTLAAITLQRTLIGLDEPLVIPGRRLIKYGTLLKTRRKDIQPRRFYLFSDCLIIAAANSDTSSLVFEDESQLSSSKLLYSVQNHSNDHSSDSSIDRCSSQSTHGLGGANEILHLTNKLYLSDMTVISYDEWPMLPSESLSSSRTMPSISSRPIPSLRHKFEILSPQCSFSLYASTKAAKDSWVSAIRDTQSEFQTSLPSIRKSSELSERPLSFTSLSSDGTIFDGDLSESEQVSMSTESRRPKSKSMLFTSSQTTLPSLEDYHAPVWVPDSLVKRCKRCSEPFNIWRRKHHCRLCGNVFCASCCSGLFLLRGTASKVPNVRARVCVTCYTSNFCSSMPHTPTRPRMSRSLSSSNSDLLDTSVLSSSPLTSPTRSNASLRPVLHALPESTSMSTFVPSSPSASCASAFVSLPPLSRAESVNDFRAPPKSVLSPITNAPAAKPSKPHRRKWSIVSVPDENKSELPRVQVETKTVGLPTLEQHIPFNGMVSSASTPALTTYTSSHSILRRNTSRESLRTSQAVTWLQSVLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBQ6</accession>
    <name>A8QBQ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UEV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728938.1">
        <property type="nucleotide sequence ID" value="XM_001728886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBQ6"/>
    <dbReference type="STRING" id="425265.A8QBQ6"/>
    <dbReference type="GeneID" id="5853244"/>
    <dbReference type="KEGG" id="mgl:MGL_3932"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3932"/>
    <dbReference type="InParanoid" id="A8QBQ6"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UEV" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="289" mass="31854" checksum="9612F324CD0818FC" modified="2008-01-15" version="1">MVFVIPTQAMLIRSGSHTAHDGRVHVPYLDVWQRKIEGYSLIELVRECQAAFSIEPPVMAKPKQPLSVEASIAGRSQDASASPIRNVDSVSQKPAPVPSRPPKAIPNSTVSPPHPKRPERPEILEHLEPFGFTPGTLSNESASPSGSSSLRTDIASGEIEPSNIPAPQRPMNPALLELHAKVYAKVSSRVTEIFASHSQSKQRLHLLLEDLERGTPAIDDEIRRLRAVRDICLTNVHRLTTTIDAAKRCTAEMEMRPEPDVDRMLSATSLVENQYVIVSLREMANGHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBR3</accession>
    <name>A8QBR3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728940.1">
        <property type="nucleotide sequence ID" value="XM_001728888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBR3"/>
    <dbReference type="STRING" id="425265.A8QBR3"/>
    <dbReference type="GeneID" id="5853246"/>
    <dbReference type="KEGG" id="mgl:MGL_3934"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3934"/>
    <dbReference type="InParanoid" id="A8QBR3"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="DDH" evidence="2">
        <location>
            <begin position="73"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="265" mass="29461" checksum="DBBAC486839FB4BD" modified="2008-01-15" version="1">MLRQHKLVQLVCCVLGLLAWPLFVLYRRPTFVYPHILNMTSEDYIPSELNEYLSWTKAYAFTHVNHKEQHMTILMGNEAGDLDSAASAIALSYVMNHRQSYFTTKYSLPPSVYVPLIQTPRSQLRYRQENLLVYRSVGISVDSLLCVDDLGDLTSTAFSAASNVSLGLVDHPSLRPAWKGSGIGNARHVEVIVDHHEDDGAHEDAKLRFISSPSREPVGSASSLVAKLAMESRPNGIIPSKLADLLLSAVILDTRNVRGSPYARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC77</accession>
    <name>A8QC77_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728812.1">
        <property type="nucleotide sequence ID" value="XM_001728760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC77"/>
    <dbReference type="FunCoup" id="A8QC77">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QC77"/>
    <dbReference type="GeneID" id="5853118"/>
    <dbReference type="KEGG" id="mgl:MGL_3979"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3979"/>
    <dbReference type="InParanoid" id="A8QC77"/>
    <dbReference type="OMA" id="TICHLPP"/>
    <dbReference type="OrthoDB" id="3354588at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="212" mass="24061" checksum="9FA52E85C9419523" modified="2008-01-15" version="1">MEFCEAGSMDSIYRRVKSRGGRVGEKVLAKLAESILKGLEYLHQRRIIHRDVKPSNILVTRNGQMKLCDFGVSGELINSVAGTFTGTSTYMAPERIMGRPYTITSDVWSLGVTILELALNRYPFAEEGEAPMGPIDLLFFLLNSPLPTLEDTEQIRWSRSLRDFVDRCLERDGAIRVAPLTLLAHPLIRRAEHISNTDMARFVASVWRWDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCJ0</accession>
    <name>A8QCJ0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728847.1">
        <property type="nucleotide sequence ID" value="XM_001728795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCJ0"/>
    <dbReference type="STRING" id="425265.A8QCJ0"/>
    <dbReference type="GeneID" id="5853153"/>
    <dbReference type="KEGG" id="mgl:MGL_4014"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4014"/>
    <dbReference type="InParanoid" id="A8QCJ0"/>
    <dbReference type="OMA" id="ITSFSEC"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF14">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52398" checksum="229F2994099C241A" modified="2008-01-15" version="1">MPRNLLCPPMRFGTVAFPLPAQDSDSDSSLGPSSSSRVTSFSECVYRGAYPKPRNLRFLETLHLRTIISLTPKPITDDESLETWSKSQNGGAGIHVVHVRTEKPKEDSGGLTREGAARALMEVLNSENLPLYIHCLDGVDVTSTLIACLRKIQGWKEPAIHDELARGVYASTSKSAGPKESAPKHLLQFVERFGQPDGVLLPQRDRIPGWVWPRISVHLMSHDTWDSRPATVRHPTLDIHFERSESYIASQQARFGAVWAVFDHNRSRTPSLLSISDSSEGVAPDISLGSVKPSPVPERQQMYRRFSDFTHEKLTRAFLGQRDRDMEQPSDMCAFMSVDDQDLRTPRAKPQYVEGDVPPLIGLDLRTHKAVAARAAETDALAGGAVSPDERTPLVVAQDAQKHRKPEAFQTEEPDDIPPLGLSPHNAMVGEDNDDRIVDLVDDMEEECDDMDDDAEQEEPSLALQALNLEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCK9</accession>
    <name>A8QCK9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_4020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728853.1">
        <property type="nucleotide sequence ID" value="XM_001728801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCK9"/>
    <dbReference type="STRING" id="425265.A8QCK9"/>
    <dbReference type="GeneID" id="5853159"/>
    <dbReference type="KEGG" id="mgl:MGL_4020"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4020"/>
    <dbReference type="InParanoid" id="A8QCK9"/>
    <dbReference type="OMA" id="ANIYERT"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP41639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="420" mass="47556" checksum="13E8AA11666152CD" modified="2008-01-15" version="1">MLRGHSAGIAVCACVQQLYGARVHESPTCIPTHPLTQLYFCEECYALRCNDCIDWEISSTYCPSCLFEVPGTSVRAQKSQCARNCFTCPVCTHVLSIVGSDPPRREALTAPEASLGIAPFFLSCSCCRWDSKRIGLVAEKAADLSAVFHSMEQNAWPMQEYERLIEHMAPEVQANIYERTRKTRSSRRFRPNLVRPPPSNYHADYEPTRSQALTKYASRLSRQCGLVQRDMMQVSTVQQRWTMPCEQPYQVTALHPRRVRLLCKLSKRCSTCRHILVRPEPRTNSNAYKIKLLASQFLPSCTVMPSANGLWTLTLTNPLMDAMDITLRCVGAELSIRHVQVPAFVDAFEMDDDDVAARGLAPVTPNTGWDAFVHGTYVYRHHAVLSVRVRADMQVLPLEIQWSVAETMRSHTFWSLVPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD22</accession>
    <name>A8QD22_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chaps-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728755.1">
        <property type="nucleotide sequence ID" value="XM_001728703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD22"/>
    <dbReference type="FunCoup" id="A8QD22">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD22"/>
    <dbReference type="GeneID" id="5853055"/>
    <dbReference type="KEGG" id="mgl:MGL_4090"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4090"/>
    <dbReference type="InParanoid" id="A8QD22"/>
    <dbReference type="OMA" id="IEAYQHC"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="71573" checksum="72E363AF7138B788" modified="2008-01-15" version="1">MGDTFATLPEFFETELTESLRSRTESLVSFRELGPPDLCHVLKSNGRKDLGSYHLVSGVDASSSATLATYITSLSYELEHSTAWIGSKSTFKLKGGVYCCFNAFSRVDLRVEVCIPGSVQAYTVNVRGERGEATPEIWQETYLSGVLRAILYADDPNYSLLGYRKIDPIPTPDHEVRFLMAAENLFFKGWQLGSEPEIQVATIVNNHLSVGIFKYFGELSRYEQAVNLFEKLWAREHEVAALVAKAYLGMNEEIKAVQIMHKSLQQNPHSYVVLHVETDFLRSKGQLIWAVELAKQAVCCAPSEFVTWAKLAECHIEAENWAEALLTLNSCPMFTYNEYDLHRIPPAARTHFPIPPLALQSKILDESQLGNIETDPALMRLPAPALRGTFACAYAILTKLVSKLGWDELLRYRSEVFVMEEEYRNQSTKPSSKSNNTTQHDTSSGTLDKSKEGHWLSFTDKRLCERWLDNLFMVLYEDLRIFTIWRAEQAHYDAQSLPYERPGSDWEILGELALRLHHPEEAHDAFVQCILTKNSPKAYTHLLEYFTKICNVEKALSMAMHLTAYNHRWYGDNVFPGTVGKHLFQLIKVEGLGKVSNTLVSMKPRPAMLRLMQWYFSYAQDFRLPGSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD23</accession>
    <name>A8QD23_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_4091</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728756.1">
        <property type="nucleotide sequence ID" value="XM_001728704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD23"/>
    <dbReference type="FunCoup" id="A8QD23">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="5853051"/>
    <dbReference type="KEGG" id="mgl:MGL_4091"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4091"/>
    <dbReference type="InParanoid" id="A8QD23"/>
    <dbReference type="OMA" id="TIFNMAC"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="201"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="642" mass="70970" checksum="709E4D010BC251E6" modified="2008-01-15" version="1">MAEPLSPTQNSHTVSNDEPEVIPISIPPSEAAKLAEDTSPRHVEYAPVSSIFEQATHNYQNTSVAFEKDHESSRAPSMPARSAASAGQAWNTLTSAPSRSSLKPLTSRTARGRRASVNFQDSNATGPRRLSYSSFNDDPTTDNSDVVMGQGATTLETGARIPHSINYGGEEEIKSDIIIVEWDGDDQELGTTWSYLTRCYITLLVGALAIASSMTSSLPSMLIEGISEHFQVSEEVVKLSSFIFVAGYCLGPLIWAPYSELFGVRWPFILSTAGSTIFNMACALSPNIGGLIIFRFLAGAFGSCPLVVGGGAMANIWPKELLGLGMCLFSMSPMAGPSCGPLIGGYIAVEKASWRWGYWACTILTGFLTLLSFLTLRETNPGINLKKKARRLRKKTGDDRYKAPVELRTIEIREILTRWILLPILMFIYEPMLQAMTMYMSFVYGVLYLFFEAFPIVFGVYHGLNELQIGLTFMGFFTGCIMGGSFYSLVENRRYVTSMKNHPQGILPPEQRLMVALYGAPLLVISLFWFAWTSYSSVSIWSTIAASTVYGIAMFFIFFALMTYIADAYRAQTACALSANTIVRSAFGFGFPLFATQMYNRLNPQWATCLLAFIAVLLFPIPFILFRYGPWLRSKAKYAFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDT6</accession>
    <name>A8QDT6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000023">
        <property type="protein sequence ID" value="EDP41422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728636.1">
        <property type="nucleotide sequence ID" value="XM_001728584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDT6"/>
    <dbReference type="GeneID" id="5852935"/>
    <dbReference type="KEGG" id="mgl:MGL_4235"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4235"/>
    <dbReference type="InParanoid" id="A8QDT6"/>
    <dbReference type="OMA" id="EGRAESM"/>
    <dbReference type="OrthoDB" id="3363403at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="307" mass="34215" checksum="AFCBA490C3746954" modified="2008-01-15" version="1">MAAVHTLWAFQAQPATRELRQRQAHHADLNEADSSEDEIDDTSPLRDEGMVFNGLRASMTSGGLPHDMLALAEQAEDRRWLQSTNVVARAGSTQETAEVATRQRTLQEARRAARGQHLPWRGQAAEDARLLRVLDGVPPLGSTDDADQLSDWEETFEIAKQERIRFGERDIVQIGRRRTLHEEELSRADDDIQQRPSAMGITDVSPLPDLMPPPPPLLVPTPWDSMSADMDPNSASWSDTSRSYSRLSIPTRHGNRPRTSLPHRWTPQRIPATNAAIAVAALDHVAQQSHYMGVDLDGDVDDMDTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDW9</accession>
    <name>A8QDW9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_4241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000024">
        <property type="protein sequence ID" value="EDP41402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728616.1">
        <property type="nucleotide sequence ID" value="XM_001728564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDW9"/>
    <dbReference type="FunCoup" id="A8QDW9">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDW9"/>
    <dbReference type="GeneID" id="5852930"/>
    <dbReference type="KEGG" id="mgl:MGL_4241"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4241"/>
    <dbReference type="InParanoid" id="A8QDW9"/>
    <dbReference type="OMA" id="RHWKPNA"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="87"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="303"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="497" mass="55089" checksum="1DA6A7AFED8B1DF0" modified="2008-01-15" version="1">MSKHTLADGAEAPEAERPRLEERIHENGDPEGGMGEFEDPFEDEIESDGEIVDANPDETDMEEEDEESKVPTKAYMPGTMPLEEGQTLVPDQSAYDMLHRMNVTWPCLSFDFLRDHMGSQRQTMPHTAYLVAGTQADTAKNNEVLIMKASAMHRTSHDDNDDDDDDVDEDAILEYKTIPHLGGVNRVRAAPTTTPTSELEPCLDPYPVATWAETGKVHIWDVRPLFNALNQPGTKIDKKKVESPLFTINAHRTEGFAMDWGGLLGGGSSGNTGHLRLLTGDMHSKIFLTTSNNTGFTTHAQPFESHTSSIEDLQWSPAEPTVFASCSADRSIRIWDVRIKSHRSALAVDAAHDQDVNVISWNHGTQYLLLSGGDDGALNVWDMRAFKHGQRPSPVAHFEWHQAPISSVEWHPDEDSIFAASGRDDQVTLWDLGVEHDEDEDPAQLPKGPNGEPVPSQLLFCHHGATDIKEVHWHPQIPGVLGTTSSDGFHFFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQZ2</accession>
    <name>A8PQZ2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732773.1">
        <property type="nucleotide sequence ID" value="XM_001732721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQZ2"/>
    <dbReference type="SMR" id="A8PQZ2"/>
    <dbReference type="FunCoup" id="A8PQZ2">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQZ2"/>
    <dbReference type="GeneID" id="5857079"/>
    <dbReference type="KEGG" id="mgl:MGL_0548"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0548"/>
    <dbReference type="InParanoid" id="A8PQZ2"/>
    <dbReference type="OMA" id="GDEPYTF"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="227" mass="25515" checksum="B44C732ED79422D3" modified="2008-01-15" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGEDPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASYENVREKWLPEVRHHCPGVPCLIVGTQVDLRDDPAVIERLARQKQRPITTEMGERVTRELGAIKYVECSALTQKGLKNVFDEAIVAALEPPVVKKKVRLFRFSNDLDLHTLFSDEMCNSLSACIERKAIYNMDLIPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR88</accession>
    <name>A8PR88_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732856.1">
        <property type="nucleotide sequence ID" value="XM_001732804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR88"/>
    <dbReference type="STRING" id="425265.A8PR88"/>
    <dbReference type="GeneID" id="5857162"/>
    <dbReference type="KEGG" id="mgl:MGL_0631"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0631"/>
    <dbReference type="InParanoid" id="A8PR88"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="492" mass="53605" checksum="46B184B45F1A5027" modified="2008-01-15" version="1">MNDDNESELEDAAVEAIVLHRYNAGQDRVEYLIQWQDATDGAAFSWEPEENAVDADELVYRYWREKRGADHAAAREYVEATKRNQALHGVDHPPTKAETVDPSSRVAAADTPSNVTGSELEPVARPTLTATTNTSLSVAPNSVRESQTVNAEGESTLSATDSQPRAYGTTQVAHFQNSVSKMCTGSEPHVVDHPLSGKRIQIHRSTQSNLDRESPTSSRRSSPHPTAPESSLNSGTTPLLTAPMSSEPVSSQFLRNKGDSHAVDSSIIQSIPENASIEREFQEQFGVDTTEPVSAAKPRAASEPPPGNLLVTRKLPAYGNPVTNANSFCSPVTLTPSLSNLVPKTASDDPAKHATAILESKRPRLDSDDPSLAKKHSNTYAKDWASSSSSMSFTPAPKGEKKKFVDQTQEPEKEESGDWDAVRVRVLTLRRQDAELHALLQFPHGTYLHPVSVAKKRCPQALLAFYESRVRFTPPAENADAAHSMPRDCPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRI8</accession>
    <name>A8PRI8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732287.1">
        <property type="nucleotide sequence ID" value="XM_001732235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRI8"/>
    <dbReference type="FunCoup" id="A8PRI8">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRI8"/>
    <dbReference type="GeneID" id="5856593"/>
    <dbReference type="KEGG" id="mgl:MGL_0062"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0062"/>
    <dbReference type="InParanoid" id="A8PRI8"/>
    <dbReference type="OMA" id="LFACEVE"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="162"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="496"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="674"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="800" mass="87152" checksum="2E2BC9684E51FF50" modified="2008-01-15" version="1">MVFLTTTATTTMPVEHEPRPSGQISALAFSPNGRYLAAATENCFVYVWMMESQKLVRMHAAEAVVTGLSWHPSKDVIAWTDMQGQLTHWESVLGTSMPSAREDVPMAESSTHAAGLEPMEHELDDLFDDTPLDDNAGDEPRPKRMRMIPPDVAGKSVVRQPSFQPSSTPMIAQRRYLAVSNFGTLTSIDQDTHQTVVFESYDTSARRNFRFTDHFGYTMASMASQGILFACEVEGGNPSVIFYRPFDDLPGIQMEWSVNLPPGETATAVALGGIPNVGSFADMHEGSSGVVDESFTSRATSVVSTSRGMLRFFGPSGMQCYVWALGAPVVALAACAYSVMVVYEAAASTSSNTHLAYMVIELSQWCIMQQGTLPVGPNATLTWLGFDELGTPAVFDSAGMLYTLNRVWRPGQGRWVPSLDCELALLPKDSDSNVYTDAPIKPRVRLWPIGVTGTHLLGLLIPSSQLYPQPSGPRPLVQELELTISMAQRESAATPLEELALRRSLLASAVRDTQAATGLELRPKRLSVQESDPAVLDMEADKALLQLVHLAGKADRYARALDATRSLHSESTLDAALKIAHFLHLPSLADRMERVRAPLVVYQQSLDEVTTRSCGTDALLRNFAHVPVPITSASSMPPSDARHDHARFALQQEGFGPRVQRWASKPTLAREGLSHFHQSPDLGPTPSDWSSSLHTATDEPTSSMPSQSLDHDSVPRSMTPTLPMRANPFARTHSVAKERQLQKSSSFFDRADAASASAPDEADGGVVPAGKRSTAPSSSRQATLARFAYKEPSKMPKERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRV7</accession>
    <name>A8PRV7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732363.1">
        <property type="nucleotide sequence ID" value="XM_001732311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRV7"/>
    <dbReference type="STRING" id="425265.A8PRV7"/>
    <dbReference type="GeneID" id="5856669"/>
    <dbReference type="KEGG" id="mgl:MGL_0138"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0138"/>
    <dbReference type="InParanoid" id="A8PRV7"/>
    <dbReference type="OMA" id="KRSEHVW"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="435"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="836" mass="92717" checksum="3C33BA759BA6C36C" modified="2008-01-15" version="1">MLSATSPGGAQGGAHGSSLRVMDTNDPLSVVRRALDAEEQLIRVSDSETHETYDVTLSRTMPYASPLVMPVHLDEKKERLQPTLLTPPPTRRRRLRWMRSSEDNRITAETPPSEPSQRPWASYVSPWSYSRTDSPGVVPSSGTSGHVASPATSGPSSVVEPSTPHSPVMSGPSSAAAASNDGSMATPPMPTHLSGTENTSALPSSGAQAVIPTGPDQMSQVPAPSQLAPMPVSPHPDTKFASPHTPLPPLSNIQSMLGQSLSSQDITASSARGDNVPARSTTTSPQVELPSISTTVPSSVHALDHTQSLDHPGLHTIPIQPQSQTLSSSMCQTRSETQSRSPSQTATQTHSRRLPPSEFADHIPSGATRASSMQARQKNRVSAVSNASAAERTFDEEMAANANALRLSWRAKGQHAPDVSHTNVSVRLKGNLIGEDHANYVLMYHMLTGIRIAVSRNESRPRMPLTQADFVAKYKFTFDIIGKELRPSSNYDFKFKDYAPAVFRELRVHFGLDAGDYLLSLAAKYILTELGSPGKSGSFFYFSHDYRFIIKTIRPTEHKLFIKFLPAYYEHVRANPHTLLSQFYGLHRVKLPGRKKIHFVIMNNLFPSDRDVHEVYDLKGSTISREQTSTKPTAVLKDMNWIKRGRFLELGPERRALFERQLRSDVALLQRLQLMDYSLLIGLHDLSYHARPNVSPIDKSAPMLRRPSILVSRVDGPCHEKSYSPSSRGDRDGAGAHLHFSRNHPPETTLQDMQGKRAEQQHSLFYQDEGGFRATDEQDRPLGVVYYFGIIDLFTRFDARKRSEHVWKAVWHNRHAISPVPPVEYGERFIQFLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRY3</accession>
    <name>A8PRY3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="3">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0154</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732379.1">
        <property type="nucleotide sequence ID" value="XM_001732327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRY3"/>
    <dbReference type="FunCoup" id="A8PRY3">
        <property type="interactions" value="679"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRY3"/>
    <dbReference type="MEROPS" id="S08.A56"/>
    <dbReference type="GeneID" id="5856685"/>
    <dbReference type="KEGG" id="mgl:MGL_0154"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0154"/>
    <dbReference type="InParanoid" id="A8PRY3"/>
    <dbReference type="OMA" id="SLRDFQC"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04857">
        <property type="entry name" value="Peptidases_S8_Tripeptidyl_Aminopeptidase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034051">
        <property type="entry name" value="TPP_II_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046939">
        <property type="entry name" value="TPPII_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048384">
        <property type="entry name" value="TPPII_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022229">
        <property type="entry name" value="TPPII_Ig-like-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12580">
        <property type="entry name" value="TPPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21316">
        <property type="entry name" value="TPPII_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="38"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="12">
        <location>
            <begin position="566"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II galactose-binding" evidence="13">
        <location>
            <begin position="689"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II second Ig-like" evidence="11">
        <location>
            <begin position="812"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1270" mass="138731" checksum="117AD0E5CA4EF2F8" modified="2008-01-15" version="1">MCTKSATYGVADTFPKHGLLPKQATNSRSRQRFPDYDGRNVRVAVLDTGVDPAALGLDGPNKVVDIIDCSGAGDVPLQQVEAQARTDDSAILELESPTTKRKLLVDAAWPNPSGVWKVGTKRAYDLWPTGLVERRTKERKKAFDVSHAALLQRALDELASERASTPSSTSDAKDRDAAAQRCEELQARVSVLKDMHKAWKDPGPVLEAVVFHDGMHWRAVVGGAEGDVIDSSKGEPESQHAMVLDLREKPRLTDYRLEREWAYFGEMDLLTYSVNIMNDGQLLSIVTLSGTHGTHVAGIIGAQTQDPATDGVAPGTEIVSLRIGDARLGSMEQGQALLRAAQALIDTRCDVANMSYGEDGAFGVEDKGAFAHALHQVIREHGVCFVSSAGNNGPALTTVGQPGGTTSGVLSVGAYVTAGDMQQAEYALVERGVPSNVTTWCSRGPTADGAAGVSIYAPGAAITSICRYALQSTQLMNGTSMSSPNAAGAVALLVGACKPEGITPTPFRIFRAIQESGADVRDPQGIKFLDVEKAWDYILAHRDDPYADADMRVRVTRAGKPLNVVDQRGVYLREVEETHRTTQFLVTVQPTFRSGETQRAYKLDLKTSLSATQPWVHVPEFLALGGNGRTFEIRIAADALPPGLHTAQVIAHDTERNGAVVFDVPITVAKPVVLPTATYAYPRVRLASGDIHREFVQVPMGATWADVRVRSVKHEAPGTSVRFWLHMLQLVPQRRLSKVEQHFVLALNENEPISKRVPVYGGMTLEVCAAQFWSSKAGFELELDVEFHGLDTVPKLVAHSGDAHTKVDVTSLVRCEDLKPSASLDTRRTYVRPSKYVLRPLREPRDRQPSGHQLHELVLEYPVIVKDACALTWRLPLSGYLYDASVTLLTQLLDVNQAQVAFGDVYAKPVDVAKGEYTLRVQALHESAAVLDHLHAMPLSLEQKLKKDISLDVYRDHVDLQSHVRPAKEALKLHKGERAVLCIDTALHGERWPSDGVSVHTGDVLCGTLTLGGSSDAKAAKVPLDVVVGLPPPSKSAATAAPNDPQREPASLPTLLAGLVCKVPESDKSAFVEQLVQKYPTDLSVRVAALDACDAEDADASLRAAQGVRECIDETALRLWLGAKQPPTAEQTHEQKATAKTMQTHKAALVNALVREAKAHAQRDPSSQVCTDAIMHARQYVDDSDARLRAMHTNLLTAWHQRNERYGYALQGVRKQLDDLGRGTSDTRDDLRRAHDLQCELLEHLRWDVWRHYETRWAWLRRPSTGAAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS07</accession>
    <name>A8PS07_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732394.1">
        <property type="nucleotide sequence ID" value="XM_001732342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS07"/>
    <dbReference type="GeneID" id="5856700"/>
    <dbReference type="KEGG" id="mgl:MGL_0169"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0169"/>
    <dbReference type="InParanoid" id="A8PS07"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="193" mass="20789" checksum="98EF2AF0E2AF0CC4" modified="2008-01-15" version="1">MPNLSAAGQSLPNSPFHPVDQPVSWNTVPELDLNVVPSRHFSDTSGDESDGDQTTDSLETRFGNTSWETSTAPTPLPSTSAPLSYSLDTSHWGIAYNNSPMLASQGPPNTQPSFTGKQRETAPTSDPVFPSSMFPYSAPSSLTPTSAPESMDVASTKLEPPPIRLDMPPIGTSDHLAPRRKTPLSFHSYVHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS38</accession>
    <name>A8PS38_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0187</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732412.1">
        <property type="nucleotide sequence ID" value="XM_001732360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS38"/>
    <dbReference type="FunCoup" id="A8PS38">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS38"/>
    <dbReference type="GeneID" id="5856718"/>
    <dbReference type="KEGG" id="mgl:MGL_0187"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0187"/>
    <dbReference type="InParanoid" id="A8PS38"/>
    <dbReference type="OMA" id="RASECQQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="174"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="836" mass="94180" checksum="C08B346275CF8650" modified="2008-01-15" version="1">MSTSAEVRSELAELDRAEEARSVRMKASLQQIVHVLQNTQASVKEDMAPSLDRAIQRVGALEKRFQTTASMAEKLYHEMNVLYEERRRVEEAMHWCAEVTQLRTSLGLLADALERPDWDACIRYCRDALSVSGDVLHSEFARAVVVRILLSNQEPILTECQPTSMHPEMPTQFLSQLRTSLLQKISQNFEHYTRERNEEQATRFLGYFAAIDAHEEGLAAYRYVCACVQDFLATFYEICANVTVILLALLYTPMVQTWRNVFVCQVRLFQPRLPIASSNSVYYGMLWTALFEYLAIFINKHQPVVDRLLHAPGHSNFLQGVLPSLEREWTRLGLSILEAWHAERQVDKIVAQVNGAKFVALEKVRAVPFTPGRIFGQEDRSSNPANSAMSTSSPAVSMSDSLHVDPLLCEMVSFSAQWTLFEQFLRRSMQPAPDVRMLHTGLQDALTNVMMQVYVPLQTYALRASVEQVHNLDTPDLQSRSYSSSLPDDMFFALRAVLTRALSTSSLAIVERVISHAISIVENDYVEIVVLRMDGCRRALNISRLVDGPRRSAAVREVRTTICVYLNVLDVSAMYTDRILADLSSTTFLEAYFDAESGSATEFDASLGSDPSTNPQSGKKDAPAPLTPHLSALALAQSAVGRLSVLTPKLRTTLHFEMEELFRFLVEPRIQALVSDVLRDMEYRLDEISYARVKESDAMADRVRTGWNSCILGFRDQLTESNYALLFTMAVDALVLPWEQAVMQLAFTELGALRFDKDLRGVLTALSDLASWGIRDKFLRLQQISYVLNMDEDETDTNDVFEAGIASGISWQLTPAEVQSVRSLRVNTAPQERSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSE9</accession>
    <name>A8PSE9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732470.1">
        <property type="nucleotide sequence ID" value="XM_001732418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSE9"/>
    <dbReference type="STRING" id="425265.A8PSE9"/>
    <dbReference type="GeneID" id="5856776"/>
    <dbReference type="KEGG" id="mgl:MGL_0245"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0245"/>
    <dbReference type="InParanoid" id="A8PSE9"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12763" checksum="BD3004F741FBA2C9" modified="2008-01-15" version="1">MPAFYPVTFATELRLMLPETMTTTIELPKRNETTTNSKKSDDKKTKEAPKNLVEFLQRYWIYLLPLLVLFVMPAAEPAPEPEKDNGSAAHVQQGRVKAGPAAGGGKGSRNHGKAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSJ4</accession>
    <name>A8PSJ4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732493.1">
        <property type="nucleotide sequence ID" value="XM_001732441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSJ4"/>
    <dbReference type="STRING" id="425265.A8PSJ4"/>
    <dbReference type="GeneID" id="5856799"/>
    <dbReference type="KEGG" id="mgl:MGL_0268"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0268"/>
    <dbReference type="InParanoid" id="A8PSJ4"/>
    <dbReference type="OMA" id="RRMAYVH"/>
    <dbReference type="OrthoDB" id="2536675at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="26826" checksum="4E1805DC4E87A4DF" modified="2008-01-15" version="1">MWHVTDSAWPNHVFVVFEDTSKPTRAGADAPAEAASATPGLRRWHAHVLSAEIHTLLRQSSLPGPLGSPAGTPGPGAWIQRGAQVLLDGFSFRVKLGAHSQMRRGALDAVGEQEECILSIGNVIVGSDRIAGGIVEIQYLPLTRLAPDSTLLGSILTMLLPPDIVHLLVPPSAPPMPLSLPTMALPTMISPTQLAEIVPASGTSSSASFTPGAPGFDPWEDEVNTDSIGWSGVEMRRRMAYVHLVMLRAEGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSK4</accession>
    <name>A8PSK4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lumazine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732498.1">
        <property type="nucleotide sequence ID" value="XM_001732446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSK4"/>
    <dbReference type="FunCoup" id="A8PSK4">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSK4"/>
    <dbReference type="GeneID" id="5856804"/>
    <dbReference type="KEGG" id="mgl:MGL_0273"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0273"/>
    <dbReference type="InParanoid" id="A8PSK4"/>
    <dbReference type="OrthoDB" id="10258924at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="120"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="120"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="293" mass="31815" checksum="94AB343CE076DBEC" modified="2008-01-15" version="1">MFTGLGTLRVSWKRCTYIFKVECVARIVDVAQVDAQSGSYALTIGDCALILGDCHVGDSIAVNGVCLTVTQFSLEAHGGSFRVDVAPETLFRSNLGRLQVGDRVNCERAMAPTTRFGGHIVQGHVDTVATLQAVEPNESALTLTLRLFHDTRAGVDAHLPLPSTLAPYLVPKGFITLDGTSLTLIDVSPPQGGALQRRTEDDVTTPASETIEFTVMLIPHTQDHIALPQKPVGSLINVEFDMVGKYVYRSLLGQFERLDAEHGSDASALSMSMLERVVERAMQNVSERHRSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSL8</accession>
    <name>A8PSL8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS15 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732505.1">
        <property type="nucleotide sequence ID" value="XM_001732453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSL8"/>
    <dbReference type="FunCoup" id="A8PSL8">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSL8"/>
    <dbReference type="GeneID" id="5856811"/>
    <dbReference type="KEGG" id="mgl:MGL_0280"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0280"/>
    <dbReference type="InParanoid" id="A8PSL8"/>
    <dbReference type="OMA" id="MHTRRKG"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="151" mass="17031" checksum="3DF746254264A7D4" modified="2008-01-15" version="1">MGRMHSKGKGISKSALPYSRTPPSWLKTSPEEVVQQIVKLARKGVTPSQIGSQLRDSQGIAQVRYVTGSKILRILKSEGLAPEIPEDLYHLIKRAVSVRKHLERNRKDMDSKFRLILIESRIHRLSRYYKTTGAIPPSFKYESSTASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSW4</accession>
    <name>A8PSW4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0327</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732552.1">
        <property type="nucleotide sequence ID" value="XM_001732500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSW4"/>
    <dbReference type="FunCoup" id="A8PSW4">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSW4"/>
    <dbReference type="GeneID" id="5856858"/>
    <dbReference type="KEGG" id="mgl:MGL_0327"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0327"/>
    <dbReference type="InParanoid" id="A8PSW4"/>
    <dbReference type="OMA" id="NVYPQED"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000008">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="306"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="676"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="753"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP45338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="861" mass="95077" checksum="BFA23BE79CEE095D" modified="2008-01-15" version="1">MSDGIDIDIPILDDDLFKDRARTFVEFLDDQSGVTDYRSAIRRMLAADERRLIVNIDDLRTYNRAYSHGLLDEPNGYLPPFEHALQVLVEQLHDPLKDDIQGKLYHIGLRGSFGDNHISTRMLRSVHLGKMMSLEGIVTRCSLVRPKIVKSVHYCDATSRFHMREYRDATMYGSGPPTTSTYPTTDESGNRLTTEFGLSTYRDHQMISIQEMPERAPPGQLPRSVDVVMDDDLVDQVKPGDRIQLVGMYKSLGNRVGQSNTSTFRTLMIGNYVYVLSNKAGGGISQLPLTDLDIRHINKIARRDEVFDLLAQSLAPSIFGHEYLKKAVLLMLLGGQEKNLANGTHIRGDINILMVGDPSTAKSQMLRFVLNTAPLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMSDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPIYGQYDVHKEPGRNIALPDSLLSRFDLLFVITDDIDEKRDRLISEHVLRMHRYVQPGQPAGVPAKDNLDQVLEVGDSGNDDERHQREPDDELPFEKYNPLLHMGLQGDRRQQVLSIAFVKKYLQYAKSRIAPVLTPSAAAWISNVYANLRNDEQSGNVRRTAPLTARTLETLIRLATAYAKARLSQSIEEQDAEAAEAILRYALFKEVMHSRTTSKRRKTKRDQSAGDDEDDDDENAAFDSDDMDQDETDRQLGGKSAMQTQSFSGQNVYGTRASTRAAAAAVTTETSAATSTVSASSPASRTPQPPTSSEQLRSRAVPKPSRNEAAWKSFRARAANALSSTFAEDEFVDLATLLHAVNAAGPPISEEDARVALEAMSEENQVMLAEGACSCAGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTM9</accession>
    <name>A8PTM9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamate--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0450</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732675.1">
        <property type="nucleotide sequence ID" value="XM_001732623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTM9"/>
    <dbReference type="FunCoup" id="A8PTM9">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTM9"/>
    <dbReference type="GeneID" id="5856981"/>
    <dbReference type="KEGG" id="mgl:MGL_0450"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0450"/>
    <dbReference type="InParanoid" id="A8PTM9"/>
    <dbReference type="OMA" id="DRRPNAN"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="107"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="353" mass="38615" checksum="0B99D367AF3360D7" modified="2008-01-15" version="1">MITKNNSLLAPYLKLSQGGKVAAEYVWLDACGVPRSKTTTCNGPIKSLADLKEWNFDGSSTGQAPGENSDIYLRPVAYFPDPFRGGDNVLVLAECYNNDGTPNKANFRHNAVKIFEHCKDQHCWFGIEQEYSLMGADGRPFGWPVGGFPGPQGPYYCGVGSGRVVGRDIVEAHYRACLYAGINHSGINAEVMPSQWEFQVGPCEGIEMGDHLTMARFLLHRIAEDWGVSVSMHPKAVPGEWNGAGCHTNFSTEAMRNEGGIKAIEAAIERLGKRHQEHIAVYGEDNDMRLTGRQETGHIGQFSAGVANRGASIRIPRHVAAQGHGYLEDRRPASNIDPYRVTGIIAETVCLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTX3</accession>
    <name>A8PTX3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732718.1">
        <property type="nucleotide sequence ID" value="XM_001732666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTX3"/>
    <dbReference type="FunCoup" id="A8PTX3">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTX3"/>
    <dbReference type="GeneID" id="5857024"/>
    <dbReference type="KEGG" id="mgl:MGL_0493"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0493"/>
    <dbReference type="InParanoid" id="A8PTX3"/>
    <dbReference type="OMA" id="GRELHKI"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="62"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="270" mass="30274" checksum="45C926C3191099FC" modified="2008-01-15" version="1">MDENTLGAKTSALPSVEILVQRRKARDGSGRSSSSSSSILSQSEPERKDRNESSVRKLPGIIQHTPKVLVLDLDETLIHSRLGSASVWNTWNVRDHVGTRITDAVMNIVGLGSGIPSHARLQIRGIEVHIDGRRVFYQVYKRPWVDYFLRKVASWYHVVIFTASMKEYADPVIDWLDGGQGLISGRLFRDSCTLRNGSYLKDLEIVEEDLSRVCLVDNSPISYLLQEANGIPVEGWTHDPNDEALLDLLPILDGLRYASDVRHILGLRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU88</accession>
    <name>A8PU88_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PinX1-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732044.1">
        <property type="nucleotide sequence ID" value="XM_001731992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU88"/>
    <dbReference type="STRING" id="425265.A8PU88"/>
    <dbReference type="GeneID" id="5856533"/>
    <dbReference type="KEGG" id="mgl:MGL_0637"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0637"/>
    <dbReference type="InParanoid" id="A8PU88"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="8">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="241" mass="26171" checksum="676632217EBA5946" modified="2008-01-15" version="1">MGLSEPRKKQRLIGAATQRNTAWLNDLSLPGQRMMSMMGWAPGTGLGTSNQGMSTNLTVSMKLDNKGIGAHRHEREALEQGKADAWVGAGGDLGSLFDRLNQANQDDTTSRSPEASTSTALSPGAPVETQIEPRPAFSRLAHRAKFRKAKQLGDTSTHSMNEILGISSASKSAMRSLAPTSDSEDANARGMKHVERETRSLREARQTRQHARMGKARLVPKMARTRARQRVKSLATTVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUJ7</accession>
    <name>A8PUJ7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732108.1">
        <property type="nucleotide sequence ID" value="XM_001732056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUJ7"/>
    <dbReference type="STRING" id="425265.A8PUJ7"/>
    <dbReference type="GeneID" id="5856414"/>
    <dbReference type="KEGG" id="mgl:MGL_0701"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0701"/>
    <dbReference type="InParanoid" id="A8PUJ7"/>
    <dbReference type="OMA" id="PWHTTFK"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394">
        <property type="entry name" value="YALI0E31793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="2">
        <location>
            <begin position="245"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="392" mass="45413" checksum="AB7270657696AFCE" modified="2008-01-15" version="1">MLRRYLKRGTVRRIQCARYSQKASDKLFEDAVREEAQESSVKTPLVLQDPNDPVWTGDERLEHTVLRMLMDKYKPLRRQEDGRTAEKNRLARAQKPTDLPTTTSLEEHSRHTILKPHTPQGQPWNAVYVRPSHATSNEPQVYRGKYLSPESHKSDMAKQLAKRGITSSQLALDDRKAMGELRDSLRRSLHRDRIEKAMDIRLLRYDKTRLADAKEKPQDEEVKLPSSSQQPFLAMVGATKGLAGIAEQKIVEALKSGQLQANSLRGRPIPRDYNETNPYLQREEFVLNRMIQRQGAMPPWVQLNNDMQRDILFLRQRVQHAWICRALKNLDETNAWLDLAPVGVQWHAKSNDADNDLPSFRIEPRNEAEQRTLEWVRAFRDAAWIPARVNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUM3</accession>
    <name>A8PUM3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732124.1">
        <property type="nucleotide sequence ID" value="XM_001732072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUM3"/>
    <dbReference type="STRING" id="425265.A8PUM3"/>
    <dbReference type="GeneID" id="5856430"/>
    <dbReference type="KEGG" id="mgl:MGL_0717"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0717"/>
    <dbReference type="InParanoid" id="A8PUM3"/>
    <dbReference type="OMA" id="VKTHVFH"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="502" mass="57914" checksum="47E4AE7C3A3A8AEF" modified="2008-01-15" version="1">MAPPLYTTQSGRLWHAGQILVVTVGLPGRGKTHLAHSIQRYLRWMGVQCRVYNLANMRRSMLGPLNQLPGDYFGNVQHDTETKMMRLNVMERLESTIRQFFEQGGQVAVYDANNSNHERRCLIQEEFGKMGVQVLFIECVCDDEMLIERNIRSMHHFNPDYQGWSPEDIFANFRQRIAMHELDYEPITEPTAPHVQLLNLGQRIVVNNVHGYLQNRIVFFLMNMHNQQRTIYFARTGEALIEHLYKADADLSSLGSQYAQRLHDFVMALRAKKTFASDESCATLSQQHTLSFITSSGKSVLSDDVEGWDDECRELQVWCSTRKSSLNTATPFRLQGTRVMEMTQLGELKPGVVDGMTEEDLHTRFPRYQEEQAKDPYSFRFPRAESYHDLAIRLESVILELERAREDVLIIAQPSVLRCLIAYLQGNKPQEIPFIQVREGDLVEIRPQAFGLATRLFSFWDPEKEREQRDIDFAMRAAMAVSQDSESRLPQHTDLHGNSLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVH1</accession>
    <name>A8PVH1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731596.1">
        <property type="nucleotide sequence ID" value="XM_001731544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVH1"/>
    <dbReference type="STRING" id="425265.A8PVH1"/>
    <dbReference type="GeneID" id="5855902"/>
    <dbReference type="KEGG" id="mgl:MGL_0864"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0864"/>
    <dbReference type="InParanoid" id="A8PVH1"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="151"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="278" mass="32370" checksum="670B2B9777CBD55D" modified="2008-01-15" version="1">MTFYLQLGNVDKARQVARRAIQVIHFREEQEKLNVWMALLNVENMYGSPETVEAVFKEAAQYNDALEVHSRMLSIYEHGNKIDDAAALFPRAVKKFSFVPDMWIRWYEFCLRHDREDEAHALVPRSLQSLDRKQHLRVLTAYALAEYKLGDVEHARTMFETLVSRYPKRTDIWWQYIDQEVRLENAAGARSLMERCLAARKHTTKQVKSLLQKWLVIEKRVGDEAGVQRVLDRARAFVASVQKRAASIGDDDARDEDEEDAQNDGDDSDDFDEGENYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVN7</accession>
    <name>A8PVN7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731649.1">
        <property type="nucleotide sequence ID" value="XM_001731597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVN7"/>
    <dbReference type="STRING" id="425265.A8PVN7"/>
    <dbReference type="GeneID" id="5855955"/>
    <dbReference type="KEGG" id="mgl:MGL_0917"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0917"/>
    <dbReference type="InParanoid" id="A8PVN7"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="77" mass="8624" checksum="69E737662D0CD57C" modified="2008-01-15" version="1">MSITSTITGAGTKGRPIVFFDISIGDTPVGRIKFELYNDVVPKYVPEVYPHNRTAENFRQLCTGECRFLSLLNLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW11</accession>
    <name>A8PW11_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731734.1">
        <property type="nucleotide sequence ID" value="XM_001731682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW11"/>
    <dbReference type="GeneID" id="5856039"/>
    <dbReference type="KEGG" id="mgl:MGL_1002"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1002"/>
    <dbReference type="InParanoid" id="A8PW11"/>
    <dbReference type="OMA" id="LFVTYYD"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12276">
        <property type="entry name" value="RRM2_MEI2_EAR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="193"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="544" mass="59712" checksum="306E59491B3A72AB" modified="2008-01-15" version="1">MPRHHPYGGYDDGPRQHRGSQEHRRPSSSSMRGRGGRGGRSRTNYAQSPYGASPANWNMSPSATPFPPWGAPFPMAPMSYGLPYFMFGGGTAEAARPPPTMYGSAVRPPMSMPMPAPMSMPVSVPSSVSPGAPMFPWNAKHMPVSPPNLRRGGGPRAGRGSHPERKSQRSRFTRSIYQPDPDAERPEDSKPCRTLFVRNVAFEVDIHALRADFASFGEIRVWFDLIHRRGMLFVTYYDIRAAEKARVAMNQKAYVGRTLDVHFSLPKDEDQEQHCDREKNQGTLFVVVQDATEPITYEAFHAHFEPYGEIRAIRTYKDQEHTRFVEYWDSRACVAAHDTLQDSEFLGGRTHIKFAWDLSTVSLVNDARTRSEAKAAAEARARADHRQPAAPLPMAAMEYSALPDNVATTASTANAAPAATGATKDTVWPRYDVAIAPEARLEQAQRVQKLLASLGSQSGQEPINAAQNTAPSLSTSQQILSEEGSASGSAPASPRSNNANVCRTDMDAQHGDHEEVDAAVKAPEVECTESVRTPPNAATDEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW17</accession>
    <name>A8PW17_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731738.1">
        <property type="nucleotide sequence ID" value="XM_001731686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW17"/>
    <dbReference type="STRING" id="425265.A8PW17"/>
    <dbReference type="GeneID" id="5856043"/>
    <dbReference type="KEGG" id="mgl:MGL_1006"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1006"/>
    <dbReference type="InParanoid" id="A8PW17"/>
    <dbReference type="OMA" id="ENERHTQ"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13585" checksum="E59FC7B13D888A49" modified="2008-01-15" version="1">MDGGPTTLRVRDVDVPVKPTPPGPEECCQSGCVNCVYTLYADDVDEHNKAMQDIRSRLRDYDPPITADEWDIQRLGPMPHASADELENERHTQDREARQAQPADPSLAAFLELERNLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW30</accession>
    <name>A8PW30_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731746.1">
        <property type="nucleotide sequence ID" value="XM_001731694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW30"/>
    <dbReference type="FunCoup" id="A8PW30">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW30"/>
    <dbReference type="GeneID" id="5856051"/>
    <dbReference type="KEGG" id="mgl:MGL_1014"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1014"/>
    <dbReference type="InParanoid" id="A8PW30"/>
    <dbReference type="OMA" id="MDMHDMH"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="271" mass="29670" checksum="1322DD555191CA1B" modified="2008-01-15" version="1">MPLPMALDLHEKSGMGDMGGMGDMGDMGDMGSMGGDNGGMSHDHGGMSMGGGGCNLSMLGNWNTIHSCFLTSSWSINTHAQFAGTCIGVACWVILTECVRRWAREFDRAIIAKAIQDLREHDASPTEAWVEENYVADMQADTKPSRMNQETRIAFPMSGATTVLQSPPAVTVSARDYRVRPTLWQQVIRALLYAIQFTSAYLLMLIAMSYNGYVLISMMLGALIGYFAASWDTLGTINPSAIQRQKYLKPYAVKNDVAENHQNDGVCMNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW80</accession>
    <name>A8PW80_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731775.1">
        <property type="nucleotide sequence ID" value="XM_001731723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW80"/>
    <dbReference type="STRING" id="425265.A8PW80"/>
    <dbReference type="GeneID" id="5856080"/>
    <dbReference type="KEGG" id="mgl:MGL_1043"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1043"/>
    <dbReference type="InParanoid" id="A8PW80"/>
    <dbReference type="OMA" id="THLDTEW"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="77"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="970" mass="101375" checksum="1FE6CDA815C7FD4B" modified="2008-01-15" version="1">MYPTSHTYFSSENIDLPPWGPFRSTMSPVNPAQSMRRGASLDSSPGMRYDTLRDPMWSSVYPDVTQRPLSIPWSAQMQLWYYLDPSSTMQGPFPATSMQAWYEQNYLYPDLLVRPEDDAQFRPLHAYVAEIGDPVRPFLIPPKRVGHPSSASAPTPPNIPSSVLGSPHVSATNSPQLVHASPQLDPSVRATDHLRQNSAVAAAATSANVPSTTATTVSSNASNLSADDILTALRVMSQLQALMPNSTETQTLQMMQNVLATSVPHANEAGLNDILHAMQRQAASDAFRASQARAYADAEHPVHASSMPTSSSSSVHNDTNWPYNHDQELSLYSDEDDDPFSPEPKRGSDAPKQIPTVLPDASALRAPVAKPLEQAHPDRAGSIGTPSGQADASDTVAALGESTTATIAAQNPDLPAHDSMPGSDTISNPVSNSNPIDPKSTLPPKPAFLSKPQLPSGLESADPSQNSEPSRGLAKDIFPSTDPTPSRKAASHMESSTQVYSSSQVPEPSKALQAVSPSKAPKSDKALDAKPIPTSDSHATEADAAVSASVNVPPYSSVRKSSTATGLSGGSTGSNGSRGLASSSATSDSGTPTPSDPSTRSTSTSSSSATPKPASVRPAPWASASAKPAQASTPNMREILEAEQRERKAREAKERAKNSAMLASAMASMHMSQPTLTSSSSTTGGTVSTAATTPRSTGVAWNVPKSTTPAKSLSQIQQEESARSASEKAAHAQVARSSASRAQGEPDSPNEAGWVKVGSSCGKAHALPPKPIAAVKNSAGGSGQGNNNSNNGGAGAPKSSLTQVRASLPNRPPALSSSGSGSAVTTSSSAVPSEADEDGWVTMKPKHQARRDALSQMNDSIPRPSGSAAGSASSASSATRSSTSTMVPSSTPQPPSPEFVKYCRDQLKGLRANIDDFIEMLLSFPLNPSPDVTVIIAEAVYANSSTLDGRRFAADFVTRRKADAYRAVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW86</accession>
    <name>A8PW86_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DnaJ homolog 1, mitochondrial</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1047</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731779.1">
        <property type="nucleotide sequence ID" value="XM_001731727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW86"/>
    <dbReference type="FunCoup" id="A8PW86">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW86"/>
    <dbReference type="GeneID" id="5856084"/>
    <dbReference type="KEGG" id="mgl:MGL_1047"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1047"/>
    <dbReference type="InParanoid" id="A8PW86"/>
    <dbReference type="OMA" id="YSIFRVW"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008035">
        <property type="entry name" value="PRK10767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="13">
        <location>
            <begin position="210"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="14">
        <location>
            <begin position="347"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="11">
        <location>
            <begin position="347"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="567"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="614" mass="66091" checksum="1AF534014A5FF8A3" modified="2008-01-15" version="1">MDAEPINVLFCCLGNICRSPMAEAVFKDTVKKENMMDQFGIIDSCGTADYHEGEEPHSTSVRVCMKNNVPIKHQARAIRNEDFNKFHYIFGMDTNNVRNLTKIQPKGSKANDDNGTVFDPYFIGDSAFYTVFEQCQSVASGKLRRIPTARVSADVTPRTLVTVSSAVTHGRCSSSSSRFARASSQPSQKTAVYNVRGFHSSSNRLSTPKDPYATLGVKRDASAKDIKSAYYQLAKKFHPDTSKEPGAKEKFVEIQAAYDILSDDQKRASFDQFGSADGPNMGFDPFGGAGAAGFGGFHPGSAESIFESLFGGAFGGGRTARTGFGGETRGEDIEASVNITFEEACKGTSRTISINPIDRCGTCTGSGLKENAKRSTCQVCRGTGTRTFVIQGGFQMASTCPACSGTGSSIAPGDECSSCSGAGRVKSKRSIMINIPAGVDDGYRIRQDGAGDVPLMGPGPPGSLYVRIHVMPSRTWRRQGTNLFYPAQIPFYTAVLGGRVRVPTLEGDVSVRVPSGTQPGDEMILRGRGVPRLGGRKSYENHGDLMVQFDITIPRSLSKRQKELLQQFADEYEGRSTSTSSSSTDAPPKADDTNSPGGNTNTDESRENNKHGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWB5</accession>
    <name>A8PWB5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731795.1">
        <property type="nucleotide sequence ID" value="XM_001731743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWB5"/>
    <dbReference type="FunCoup" id="A8PWB5">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWB5"/>
    <dbReference type="GeneID" id="5856100"/>
    <dbReference type="KEGG" id="mgl:MGL_1063"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1063"/>
    <dbReference type="InParanoid" id="A8PWB5"/>
    <dbReference type="OMA" id="YYFIESL"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725006" description="Pyrroline-5-carboxylate reductase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="8">
        <location>
            <begin position="192"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="6"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="300" mass="31739" checksum="1FA6F98B2B8B1724" modified="2008-01-15" version="1">MTMAVLACGTMGTAILSGVLDCQAAMSRGEVSTDLSATSQAGETFERVPLPRKYIATVGRDSTAKRLVRTFEEAGHTNVEVFKQNNVEAVRKSDLVLLCTKPQRVSEFLSEPGMQEALEGKMVVSIAAGTTIAKIKQCVPSSTKVVRAMPNTPCRIREGMTVISDVKELSHEQRDLLATIFSAVGRCNFLDEKYFDAATALAGSGPAFATLFLEAMADGGVMMGLPRAEALELAAQTMQGAARMVLQSGAHPAVIKDSVTTPGGCTIAGLLQMEDGRVRSTIARTIQTAAEHAAGLGKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWD5</accession>
    <name>A8PWD5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosducin thioredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731806.1">
        <property type="nucleotide sequence ID" value="XM_001731754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWD5"/>
    <dbReference type="STRING" id="425265.A8PWD5"/>
    <dbReference type="GeneID" id="5856111"/>
    <dbReference type="KEGG" id="mgl:MGL_1074"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1074"/>
    <dbReference type="InParanoid" id="A8PWD5"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10692" checksum="2C8C555E59044101" modified="2008-01-15" version="1">MDTSKLLAGYLDTLAEKYPSTKFVSIVGSQCIPNYPDHNLPTLLIYRSGELRRQIVGLRPEIGLDGMRTKLAGMCLMLGEPEYRLTHSPQTLSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWH0</accession>
    <name>A8PWH0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731829.1">
        <property type="nucleotide sequence ID" value="XM_001731777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWH0"/>
    <dbReference type="FunCoup" id="A8PWH0">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWH0"/>
    <dbReference type="GeneID" id="5856134"/>
    <dbReference type="KEGG" id="mgl:MGL_1097"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1097"/>
    <dbReference type="InParanoid" id="A8PWH0"/>
    <dbReference type="OMA" id="MSDQEGW"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="90"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="312" mass="34794" checksum="109B0DFCA9F73DB3" modified="2008-01-15" version="1">MSQDAPIAVQDAIAWLEQQRLTQERNPYDIVRFGEWLLEHNYLSKLGSDVWAFLEQLGMAAAELGNQDLAELCLSRLQSRFMDSTRVALLKGVIEESHGRLDEAQSLYEKLLEKEPSNLLVNKRRLACIKTKPEGVTRATEGLAELVDIYPTDHECWLELASLYLSQNKYSQAAYALEELVLLAPHNVFYILKYAETLYTTGDIAKAYKMFLRILELGDGNLAPSSERTVDRVQGPWVRALWGLKMCTAKLLGNKALSLSQEGDIKAEHLEAVDALATKLLLDSVYAPNATFATPQSSRSAARTVLTPSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWR2</accession>
    <name>A8PWR2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731921.1">
        <property type="nucleotide sequence ID" value="XM_001731869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWR2"/>
    <dbReference type="FunCoup" id="A8PWR2">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWR2"/>
    <dbReference type="GeneID" id="5856226"/>
    <dbReference type="KEGG" id="mgl:MGL_1189"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1189"/>
    <dbReference type="InParanoid" id="A8PWR2"/>
    <dbReference type="OMA" id="DEYGMTS"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="667"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115413" checksum="C1682EFF7A517E67" modified="2008-01-15" version="1">MVDRSVTQVSRSMATHTAPEKSISSVKVQKSDPASYASAVDKKAQAKRVEAILESNGMIPRDRVHSEVAWFYESLGIDITYFILENAETIAGHIVSLYAAKISEYAKHTGHIKIDLQKRSDDSAVFIHSSDPGVSTIDTLWERRIDSEYLNKPTLDRAFRLESYRSSGLLTENAPEQLRCHFLQKCQFAEPVPDLSSEQAQDIRAVSDKTFLTKTSDHVLDIYQNVMRQALKNDGPAIEVFKVDDSTEHHVVIGYRMGTTSNFFSAMTDLYHYYGLYSTRKYVEHFSNGITIMSIYLNPLPPTDTPSVDMSILRVLEEVSLIYALPDNPFFTANGSGKSLTVQEATYAYVGWLFAQHFCNRLGTAYEALREIIDESNSHHAAVLHDIKMRLREETFTRQSIFEVIRNFPEVTRLLYARFAYLHYSDQTPATGIEPSAHEKLMPDVPLSDQELYDVIIKSASNSHERQVLLALLAFNKSVLKTNFYTPTKVALSFRLDPSFLPESEYPVKPYGIFFVVGSDFRGFHVRFRDVSRGGIRIIRSRNKENYSINQRTLFDENYGLARTQHLKNKDIPEGGAKGTILPDMGAEPSRCFEKYVDSILDLLVQPTSSGAKQPIVDFVGKEEILFFGPDEGTADLMDWGAEHARKRGAPWWKSFTTGKTASALGGVPHDVFGMTSLSVRQYIHGIIRMLGLKEQEVTKVQTGGPDGDLGSNEILQSKDKTVAIIDGSGVIHDPHGLDREELVHLAKERKTISHFDPSKLSKDGYRVLVEDRNLKLPSGEVVPDGFNFRNGAHLRYKADLFVPCGGRPESINVTNVQQLIKGETTNYKYIVEGANLFITRQARLELEKNGVILYPDASANKGGVTSSSLEVLVGLSLTDEEYIQNMLFVDGKPTPFYMNYVRDIQSIIARNARGEFEAIWRENEETGKPRSFVSTDLSRSLNLLSLEIEKTNLFEQDTLRNTILKLVFPQSLVAKVGLDELVRRVPESYLKSAFAAQVAAGFIYAKGPRASHVDFYDHISALLQGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWR6</accession>
    <name>A8PWR6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731925.1">
        <property type="nucleotide sequence ID" value="XM_001731873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWR6"/>
    <dbReference type="FunCoup" id="A8PWR6">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="ESTHER" id="malgo-a8pwr6">
        <property type="family name" value="Fusarinine_C_esterase_sidJ"/>
    </dbReference>
    <dbReference type="GeneID" id="5856230"/>
    <dbReference type="KEGG" id="mgl:MGL_1193"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1193"/>
    <dbReference type="InParanoid" id="A8PWR6"/>
    <dbReference type="OMA" id="NANELTH"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="269" mass="29223" checksum="052BB113D2AD7F12" modified="2008-01-15" version="1">MTPAPLQGVLRLYQIKPIALPYFETNAHHSNKLVFVPGLTDTIGVVPYLPRLASVIDEVGFSLVQFVKCSDLGGFGTSSLEGDAQEIAQLLEHLITRSDSPCTGKLVVMGHSTGCQDVVAFLSRERRLLSGRDGPIRVHGGICQAPVSDREYFDAHDGQNPLGQLQLAESRAYIAEGKPGTLLERSSIAQTPRYTDNGRGDGNSASALQPAMTAYRFTSLNARGGDDDLFSTDLRQDELQRTLGPALERAPLLMLFGANECVFQCHCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWY5</accession>
    <name>A8PWY5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731993.1">
        <property type="nucleotide sequence ID" value="XM_001731941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWY5"/>
    <dbReference type="FunCoup" id="A8PWY5">
        <property type="interactions" value="601"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWY5"/>
    <dbReference type="GeneID" id="5856298"/>
    <dbReference type="KEGG" id="mgl:MGL_1261"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1261"/>
    <dbReference type="InParanoid" id="A8PWY5"/>
    <dbReference type="OMA" id="QFVEYYY"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="147" mass="16757" checksum="439237C7232433F9" modified="2008-01-15" version="1">MEAVAQQFTDFYYSTFDTDRSQLGSLYRPHSMLTFEGAQTQGAQAIVEKLVSLPFQKVQHKVDTRDAQPTGDGQSLVVLVTGMLLVDDGQNPLKFSQSFTLLPEGGSFYVFNDIFRCKVDVKIVCWSRSSMRHWAFVEDFFRESYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWZ3</accession>
    <name>A8PWZ3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732001.1">
        <property type="nucleotide sequence ID" value="XM_001731949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWZ3"/>
    <dbReference type="FunCoup" id="A8PWZ3">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWZ3"/>
    <dbReference type="GeneID" id="5856306"/>
    <dbReference type="KEGG" id="mgl:MGL_1269"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1269"/>
    <dbReference type="InParanoid" id="A8PWZ3"/>
    <dbReference type="OMA" id="FWCIAIN"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="60077" checksum="0B666E3460E05F66" modified="2008-01-15" version="1">MSAVDVKKDDKADFGDANPRVVTKPVSNLGDEVLDDDDAALAQRVGHRSEFAREFKSFSTISFAFAIMGLVSSIATTFASPFTLGGPASTVWAWFMGSIFNMTIGTAIAELVSASPSAGGLYSASGLLVPHKYRATVAWVTGWLNLTGQIAGIAGTEYGLAQMIYAWANVISDGSFSANRHETVGLYYALLVIHGIINSLDSKTLARMTSGYVIVNLGITFVIIITLLATTPLHEMWGPSYTFGTIINQSGWEGQGGTAISFLFGLLSVQFVMTDYDATAHISEEVHRASIAAPVAIMVAVAGTGMVGWLLNIVLVITSGDVVHQDVDDMPGGLPMAQIMVNRMHKVGFLVVWPFVCLVAFFVVTTAMQANARSFYAFSRDHGLPDKGFFAKIYKRTGTTVNAVWLVVLCCIILGLLGFISQYAINAIFALAALGMDISYLIPIVCRQIFQDHPEVMFKPGPFTLGRGFFGRLINGIAILWTIFECTVLSIPQEMPIDEKNFNYSWVIMLGVLFLSLIWYVAHAHRHYHGPRSTMSPEQLAKLDEGVKDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX22</accession>
    <name>A8PX22_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 4E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF-4F 25 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">mRNA cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732030.1">
        <property type="nucleotide sequence ID" value="XM_001731978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX22"/>
    <dbReference type="FunCoup" id="A8PX22">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX22"/>
    <dbReference type="GeneID" id="5856335"/>
    <dbReference type="KEGG" id="mgl:MGL_1298"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1298"/>
    <dbReference type="InParanoid" id="A8PX22"/>
    <dbReference type="OMA" id="MSARANF"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="298" mass="33379" checksum="5529E15DA326483E" modified="2008-01-15" version="1">MASESSVTSTANKRPMKTGETSSTTNSLAADSEAASKSTLATVQDEKQVPTSLNTEKDGDEIRTVFQDPVKFNVKHPLYNVWTLWFDNPGHKGSGSAKERRETWGANLHKVVDLQSVEEFWGLYNNIVPPSLLPQSANYYLFKQGIQPAWEDPANGGGGKWSLQLPREKHRNQIDKLWLYTMLSAIGEMLETPAPDSKLPESRDDEIVTGVVLQARANYYRISVWTRYSDEWDTELPEGSEASESLMRGRRLIGLGRFFKTEVLGYPLDAKVGGGFSSEVEFQSHKDSEKKRGKRSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX68</accession>
    <name>A8PX68_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731161.1">
        <property type="nucleotide sequence ID" value="XM_001731109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX68"/>
    <dbReference type="STRING" id="425265.A8PX68"/>
    <dbReference type="GeneID" id="5855468"/>
    <dbReference type="KEGG" id="mgl:MGL_1344"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1344"/>
    <dbReference type="InParanoid" id="A8PX68"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11313" checksum="D7B31813FF149A20" modified="2008-01-15" version="1">MVSGMTPSTTPTQPPREDPFTPEELSKYDGTVDSKPVYVAVKAPGKGYSIFAGKDASRALGMSSLKPEHAVSDYTTLTPQQMKVLDDWFEYYKKVQSWKCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX90</accession>
    <name>A8PX90_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731183.1">
        <property type="nucleotide sequence ID" value="XM_001731131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX90"/>
    <dbReference type="STRING" id="425265.A8PX90"/>
    <dbReference type="GeneID" id="5855490"/>
    <dbReference type="KEGG" id="mgl:MGL_1366"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1366"/>
    <dbReference type="InParanoid" id="A8PX90"/>
    <dbReference type="OMA" id="NSWFLGH"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050592">
        <property type="entry name" value="GDSL_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642">
        <property type="entry name" value="GDSL ESTERASE/LIPASE EXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642:SF139">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727131" description="SGNH hydrolase-type esterase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35428" checksum="044256ADA39D9550" modified="2008-01-15" version="1">MKTGTAVWFAASLSALCVTAAQLQFPFALRDGGAAGFSRIVVFGDSLVDNGNGTYLFTNKTWPSDPAYMNGRFSNGETWPEQLASLMQVPHVDDFAYGGATTNNSVAQGMSGYNESIAVPDVRAQLHEYMESVHGKVDRNALYILSGGSNDVYYGTKETLNIWRLGNQCAATLKRLAQYLIDLGATTIMIPTLVDGSKVPSTTQYSNVIDQVGGAAYIKHFNTKLQDAVQELQSQNNQKARIVLVDLYERGREILAHPGEYGIKNTEDACLVGTTKVEKQKGVTRHVCSDPDSYFYWDIFHPTAHTHQLLAQTAQQVLQERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXA9</accession>
    <name>A8PXA9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_1385</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731202.1">
        <property type="nucleotide sequence ID" value="XM_001731150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXA9"/>
    <dbReference type="FunCoup" id="A8PXA9">
        <property type="interactions" value="781"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXA9"/>
    <dbReference type="GeneID" id="5855509"/>
    <dbReference type="KEGG" id="mgl:MGL_1385"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1385"/>
    <dbReference type="InParanoid" id="A8PXA9"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="44"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="262"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="556"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP43988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="663" mass="74440" checksum="6082CEBB1B53F5BE" modified="2008-01-15" version="1">MDAAATCTLTLDVRITKATYAQKRLDVIASLGFEQMTPVQSSAIPLFLSHKDVVAEAVTGSGKTLAFVLPILEILQRREEPLKKHELGAVVVCPTRELAQQTAGVVQRFLDAKPATSKLHGMQLCVGGTGVSPADDLQYFREHGPDILIGTPGRMEELLKRPGVKTSELDVLVMDEADRLLDLGFTNVIRSLISYLPKQRRTGLFSATMTEALSELVRVGLRNPVRVVVKVEYKQRGHGPTQDLRMPATLENLYHVSRPEHKFAQLLRILQHEARGAYHARKAIVYFATCAQVNYLFSLLARYAKSHPAALEGLRFFSLHGKQTPKRRTATFSAFSHAQTDHEKPPKAPHQDTDDAGATNASISVLLCTDVAARGLDLPDVDVVVQYDPPSDPKVFHHRSGRTARAGRHGRAIVMLHAGREEGYVEFLQIKQVLLQPYPYLVVDDTKGTLLDGQEPEGQRDGHAHALEKELRATVHQDRALYELGLRAFVSWTKAYLKHEVAYIFRLTDLPLDGMACEFALLHLPRMPELRSWHMQTKPLFTDDVPDLQTFAYADKQREKQRAARQHARASAPAPEGPRVPRGKTEAWSEQKRKKETRSLRREKKQRKRQWLQSQQEQAKSAQMLTVDADKEDDWGAEERAAKKLKKGSMTQTAFDAAFFDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXD2</accession>
    <name>A8PXD2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731225.1">
        <property type="nucleotide sequence ID" value="XM_001731173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXD2"/>
    <dbReference type="FunCoup" id="A8PXD2">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXD2"/>
    <dbReference type="GeneID" id="5855532"/>
    <dbReference type="KEGG" id="mgl:MGL_1408"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1408"/>
    <dbReference type="InParanoid" id="A8PXD2"/>
    <dbReference type="OMA" id="PACTNWK"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="156"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="362"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="614" mass="68525" checksum="AD7D0E07426EBEBC" modified="2008-01-15" version="1">MDVASGALALSPAPKMRGPPPSTGDASPSSSSGTDVPDFDEMAPSGIGGADISMPMNEAPTRSTSFADLPHEILLHVFRFALGSQQDLQACLFVCRRWCACAVQVLWYRPSCHKRSAIFQLIDVMDRPDSSFPYASYIRRLNFSMLAGELDDQLFRRMAACHRLERLTLSGCSELTEPSLAYVLSHMPQLVAIDLSGVTHVTDNTLNVLATTCSRLQGANLTGCYRITSRGVRSIAQHCPMLRRIKLGACTQVHGDALVDMLEKCPLLLEADLVQCPRMDDASVREVWLRNTQLRELKLANNHTLTDHAFPTSALRDTWTIPRAFLVCENLRMIDLTCCTLLTDETVRAIVEHAPRLRNVSLAKCVRLTDQGVYALSELGRHLQHLHLAHVSNVTDRAIIRLAHQCTRIRYLDLACCTQLTDESVFALASQLPKLRRIGLVRVAQLTDRAIYALVEHYTNLERVHLSYCEHIQVPAIFWLTLRLPRLSHLSLTGVPAFRCVELQSMCRPPPKEFNQHQRQSFCVYSGRGVHELRRFLQHVYADEALARQFGPLHPDRNRVFQAGLARQQAAQAALEAPDTVRAAPAAPSSVPTPTTYAWSRPSLTPRSRLHSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXL6</accession>
    <name>A8PXL6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1476</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731293.1">
        <property type="nucleotide sequence ID" value="XM_001731241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXL6"/>
    <dbReference type="FunCoup" id="A8PXL6">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXL6"/>
    <dbReference type="GeneID" id="5855600"/>
    <dbReference type="KEGG" id="mgl:MGL_1476"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1476"/>
    <dbReference type="InParanoid" id="A8PXL6"/>
    <dbReference type="OMA" id="EPPCKVM"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="190"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="517"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="572"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="660" mass="72568" checksum="293CC6E6E8F5056D" modified="2008-01-15" version="1">MRCTNCGSLAIDFADSQAVCSACGVVLEESQIVSDITFAENTAGGAVVQGSYLGADQVRARTSAPGFRGSSAGESRECTIANARWNINRMATARGVPAHVAERALRFFQLALDGGTATATGSQPRNFVLGRKSDYTVASCLYVACRMAKTTHMLIDFADVIQVNVFVLGRSYLRLLRVLNLQIPLIDPSFYISRFAALLEFGDETQRVVTDATRLVTRFKMDWMVEGRRPAGICGACLLLAARMNHFRRSITEIVQVVKIADVTLRKRLEEFKATPSGQLTIEDFRSVWLEEESNPPAFARARMPKKHKDPRVNLVDSTSMDARHAKSTDSRPNRHDLNENSHADGNSNGDSGIDSGDDDQVSPDKEDHGSLQAQPIRSDIDQLADQATEQEITSFLQQAEVQELSNDLSKQERERTERAKAGRVHNVSGALAEPPIKLSDSQKEAAHAADANLAPPSSAESKPNAAANDGLDDLDEEELDSFLLTDEEVKVKERVWMEFNKDYLEAALARQLKLEADQKAGIAPAPRSRKRHKPRDGTTAPTSSAAESAKQMMQQKRWSRRINYDVLNSLFPSAKGKEDTGSASGARKAHGSTNEDDGIDEDDDEDDDVDEEVDEDDTVGPSSSTKRARLDEDWMALGGLTRQDYGDEADYGDDYNDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXV1</accession>
    <name>A8PXV1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731348.1">
        <property type="nucleotide sequence ID" value="XM_001731296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXV1"/>
    <dbReference type="STRING" id="425265.A8PXV1"/>
    <dbReference type="GeneID" id="5855655"/>
    <dbReference type="KEGG" id="mgl:MGL_1531"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1531"/>
    <dbReference type="InParanoid" id="A8PXV1"/>
    <dbReference type="OMA" id="VEKINCP"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="251" mass="27284" checksum="C1C014C9118ABAEC" modified="2008-01-15" version="1">MITRTTISNRELVLKQRRDTHVAQRITLCVCVCVCVCDMVYQQPALHRACLDVMPSWISLKCYFLPGSIDVNARDHSGWTSLMIASSAGASSIVRWLLRHGADVHASNTKRITALHYASSKNHVDIVRELLEAGADVNALDGANQRPIHRAASAGHDHVIRVLLSPPPRSDGSPHPKTRVNPADRLGNTPLHLAIDSAHAQTAALLIDVGGADRLRVNTDGIVPEQMEGVGGLEQKRVRDFLAQSFGPIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY33</accession>
    <name>A8PY33_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromodomain-helicase-DNA-binding protein 1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731398.1">
        <property type="nucleotide sequence ID" value="XM_001731346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY33"/>
    <dbReference type="STRING" id="425265.A8PY33"/>
    <dbReference type="GeneID" id="5855705"/>
    <dbReference type="KEGG" id="mgl:MGL_1581"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1581"/>
    <dbReference type="InParanoid" id="A8PY33"/>
    <dbReference type="OMA" id="IGRRIEF"/>
    <dbReference type="OrthoDB" id="3030170at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039880">
        <property type="entry name" value="CHCT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21765:SF1">
        <property type="entry name" value="CHD1 HELICAL C-TERMINAL DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21765">
        <property type="entry name" value="SIMILAR TO CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1 (CHD-1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromodomain-helicase-DNA-binding protein 1-like C-terminal" evidence="4">
        <location>
            <begin position="170"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="308" mass="34966" checksum="D913790B3D6113FA" modified="2008-01-15" version="1">MLERVNDVRQWRIPVDNLKSTLNWHCEWGHKEDSMLLVGIWRYGFGSWEQMEVDPDLGLQGRFFLEEGKRHSDTTKDEDDTSTSAASAPVSTAKDETTKSKTGAGKSRPIPNAIHLVRRGDYLLKTLRESVSHHSHHHHGKRDDEGGKPRKRSSRSSSGSGRAEKSKRSAAQYSSDESDEDGYASMDELECKELMRPCKKQLKTLKDDTEHLDRDRKIATLKQCLSAIGTHIDHVIASKFANLPKARQQKWYEHLWAFSSFFWPKKVEPEKLRAIYAKLTGHATKEDTKRKASAEPTGADASKKPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY50</accession>
    <name>A8PY50_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731408.1">
        <property type="nucleotide sequence ID" value="XM_001731356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY50"/>
    <dbReference type="FunCoup" id="A8PY50">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY50"/>
    <dbReference type="GeneID" id="5855715"/>
    <dbReference type="KEGG" id="mgl:MGL_1591"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1591"/>
    <dbReference type="InParanoid" id="A8PY50"/>
    <dbReference type="OMA" id="FREFPHE"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="311" mass="35490" checksum="DCD9DEB648B30BA1" modified="2008-01-15" version="1">MALDLDACIEKLLNKQLLVDTILKEICERTKELLMMESNVVHISAPVTVVGDIHGQFYDLLEIFRIGGDAPNTNYLFLGDYVDRGLFSVETISLLTCLKLRYPHRVQLVRGNHESRAVTQTYGFYAECSRKYPDSNVWQYFTDMFDFLTLSVVIDDDIFCVHGGLSPSIHHIDQIKILDRFREIPHEGAMADLVWSDPDPDKEEFAISPRGAGYTFGASVVKHFLEYNHMSHILRAHQLCMEGYNVLYDDRLSTVWSAPNYCYRCGNLASILEVGPNGTRHFNTFEAAPENEHDGPLQAVHTRSETVEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY58</accession>
    <name>A8PY58_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-methylcitrate dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731413.1">
        <property type="nucleotide sequence ID" value="XM_001731361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY58"/>
    <dbReference type="STRING" id="425265.A8PY58"/>
    <dbReference type="GeneID" id="5855720"/>
    <dbReference type="KEGG" id="mgl:MGL_1596"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1596"/>
    <dbReference type="InParanoid" id="A8PY58"/>
    <dbReference type="OMA" id="DHSVMYI"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="49"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="319"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="56664" checksum="3F1BC8C9A4FC4AD9" modified="2008-01-15" version="1">MPLTLTARALRAGCSFRAARISGIRAMAVAAGIGKGESNVRPPPDQVMQDMADYVHSYDIQSSTAYNTARLCLLDSLGCAIEALRFPAVRSVCGPVVDGTIVPNGAHVPGTNYVLDPIRAAFNNGALIRWLDFNDTWLAAEWGHPSDNLGAILAVADWVSRTNVAKGQAPLTVKDVLTAAIKAHEIQGNMAIENSFNRVGLDHVVLVKVASAAVVSKLLGLTREQTIDSISQAFVDGQSLRTYRHAPNAGSRKSWAAGDACARAVHLALLVQRGEGGYNSVLTAKTWGFYDVLFKGREFQFQRPYSSYVMENVLFKLVPAEFHAQTAVEAAVQLHHKLRDMGKTSDDIRSIKIRTQEAAIRIISKQGTLNNYADRDHCIQYMVAVPLIKGSLEPSDYTDEFAADSRIDALREITTVEEEPRYSKEYLEPEKRSIGNAVSVELKDGTKLDEVAIDYPVGHARRRDEAVPLIASKLQKHLTGMFNDAEKEQILSLLTDHERLISMPVHEFTDLWTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY87</accession>
    <name>A8PY87_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1613</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731430.1">
        <property type="nucleotide sequence ID" value="XM_001731378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY87"/>
    <dbReference type="STRING" id="425265.A8PY87"/>
    <dbReference type="GeneID" id="5855737"/>
    <dbReference type="KEGG" id="mgl:MGL_1613"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1613"/>
    <dbReference type="InParanoid" id="A8PY87"/>
    <dbReference type="OMA" id="MFRNIFP"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="7333" checksum="2F57E243489C5D85" modified="2008-01-15" version="1">MTDLYRDPWAKREAWRKHPIFSMRYYVRHMFPGLGLGVTAFAVYCFWEKYSKPKPVAHASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYW0</accession>
    <name>A8PYW0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731550.1">
        <property type="nucleotide sequence ID" value="XM_001731498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYW0"/>
    <dbReference type="FunCoup" id="A8PYW0">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYW0"/>
    <dbReference type="GeneID" id="5855857"/>
    <dbReference type="KEGG" id="mgl:MGL_1733"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1733"/>
    <dbReference type="InParanoid" id="A8PYW0"/>
    <dbReference type="OMA" id="WVNRYGR"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="511" mass="55480" checksum="652C7452A92CDA1D" modified="2008-01-15" version="1">MSETCTVVTPTGREITVPTGLLIDGGFRPAQANDKLDVYNPATGSVIASISGGDQADVDAAVRAARNAFDNAWGKHTTPDQRAALLNKWADLIEAHTDELAELESLNNGKPVWISKSMDIATSVKTLRYYAGLADKLNGRTIELAEGKRLAFTRLVPYGVCGQIIPWNYPIMMFAWKVAPALAAGNTIVMKPAEITPLTAQKLAELSIEAGFPSGVVNVVNGLGSKVGKAISEHKGINKVAFTGSTATGRTIASAASASNLKKVSLELGGKSPMIVFEDADLEQSAKWIAMGFLFNMGQNCTAGTRVFIHNSIKDKFLNLLLDTMKQHKVGDPFDPSTFQGPQVSESQYKRILSYIQSGKEQGAKVLYGGEPYKMEDEKFKNGYWIQPTLFGDCKKGMKIVDEEIFGPVACVFTFDTEEEAIEMANDTDYGLAAGVFSKDSDRCMRVVHALEAGTVWCNNQQILNPAVPFGGMKQSGIGRELGYEGIHEYVQTKAINWNYGEKLEWPPSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ85</accession>
    <name>A8PZ85_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730898.1">
        <property type="nucleotide sequence ID" value="XM_001730846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ85"/>
    <dbReference type="GeneID" id="5855205"/>
    <dbReference type="KEGG" id="mgl:MGL_1897"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1897"/>
    <dbReference type="InParanoid" id="A8PZ85"/>
    <dbReference type="OMA" id="RTHWEAE"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037847">
        <property type="entry name" value="GRAMDC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402:SF1">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="878"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1193" mass="131321" checksum="6CE5B8B76547FD07" modified="2008-01-15" version="1">MTPHDMFSSADDPDDDWTDSEPDTGVPHVAAMSTHFPDARAHSRDTRDTHGPSERSFLSEYERRNYDSQTLVDDVQDAYPTPIRRVPLPTVSDEQDVDAPKTVPSAPRVRTAMQEAMSGETKHVPVEEEEEVPVVHATASAMERLVDSSPEEPIPPVHDRVTQEPPEREHRHQHPMHRKKGKSTDAAHGLGSDGEAMKKKKKKKKDQDGDKREPSRRRKKRFDDTVAHDLEPESAVQDDPLYDPLIDPMPPATMLINAERFDLDADQNNTSAAHRVREDLEVAARTKHEEVAAPAPLFTITSPKPTVARAGTADAPGQNMAMENGADHPAPSSPTHSLALTERTRHVSPAKGMAATNPALKQERARMHVFNYNATRLAVNVYILYWGMFATLRRLWRWENPWVTAGIAALYLVIWWRGDLLAVFFLAAFLYVATFRIWQMPAMGGEQERSAASMPASANTSTHAGASFSHPSESSAQAITRRGTEALGLVTLAPSRETLQQVGDQVLVVAHGLADMHERLKNLMLWRSPLITLRYLGWLLLFALLSMQATTWMLMRLPGALVFVLLFILAPIVEYGHLHRLLHVLSELSGAPPPDPKMPHAATRTVLDSVLAGVPTDEEYLHEKLARTHWEAERELRRLGEWVDSNRIVEEQDDDVSLSRRKTKGKSHHHVPRVSKQMWSNVNADDLPTQSKEFGAHTRGHAHGPSSEYDLPISSTSPVAPSTMRRHLRDSSRSDGLLSDERNRLLEVESMSDYGSQAGMMTTMEADTEPATTWKEGTQFRHRATKPTIDAAADTPFPPNLPRNTPRANGMNGNQSLLFATPVTDSDLPTPQARSINVENSALRNGTNSIDADGGLDAGPSSANGPAAEPQDLERASHAPAAAPLPTPTSTKAAVPPTQAAPVAPVLPATDTIPTGDIASFSHASSAGVGSVPTSNHPGNTSGPTLLPSQMSKTHSDSSQNSSFPVLNRPNTPFIPARSESLQTYENERQQRLKNWAMSPPVPTEIMNLVSSPTVASRPISSLTRDLDMGHGLHLAVFRKRLGHLIVLPTRVVFLLSYTPHRLPETAQGLTSDEEDELTHAVDGRLFYPMMSPTLIKDMVELEMDGQGLTDFQIASVPLARVPKQNDILFEVPVSQITGLKKLRKSTPILENCTEGLEIVLSESEKGLSLPAVIDRDLAFQRILTLDPQRWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ99</accession>
    <name>A8PZ99_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1901</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730902.1">
        <property type="nucleotide sequence ID" value="XM_001730850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ99"/>
    <dbReference type="FunCoup" id="A8PZ99">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZ99"/>
    <dbReference type="GeneID" id="5855209"/>
    <dbReference type="KEGG" id="mgl:MGL_1901"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1901"/>
    <dbReference type="InParanoid" id="A8PZ99"/>
    <dbReference type="OMA" id="EMIQMLY"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="544" mass="59986" checksum="444DF40438289932" modified="2008-01-15" version="1">MSSFRDTSRRQDTYKAKGAFKHDELRRRREEAQVEIRRQKREESMAKRRNLNMHQVSDAPDSEEEDEAVDGLDMKITSELPAMVQGVLSDNLDQQLEATTKFRKLLSKEKNPPIDRVIACGVVPRFVEFLRSPHSMIQFEAAWALTNIASGTSEHTQVVINCGAVPIFIDLLLSPVLDVREQAVWALGNIAGDSTKCRDFVLQQGGMQALLQLLSEDHKVSMLRNATWTLSNFCRGKNPQPAWELVAPALPTLTKLVYAMDDEILIDACWAISYLSDGANEKIQAVIESGVCRRLVDLLMHPSAAVQTPALRSVGNIVTGDDMQTQVIVASGALTPLLALLSSPKDGIKKEACWTISNITAGSPGQIQAVIDANIIPPLVHILSHADFKTKKEACWAISNATSGGLQQPQQVRYLVSQGCIKPLCELLKCMDNKIIQVALDGLENILKIGEQDKEAMGAGATNQYATYIEECGGMVTIHALQNHENFDIYKKCFYMMDKYFPDDEEDQDTGIDAPQVSDSGAFAFPTSVAAPQTGFQFGPSQNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZB8</accession>
    <name>A8PZB8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730907.1">
        <property type="nucleotide sequence ID" value="XM_001730855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZB8"/>
    <dbReference type="STRING" id="425265.A8PZB8"/>
    <dbReference type="GeneID" id="5855214"/>
    <dbReference type="KEGG" id="mgl:MGL_1906"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1906"/>
    <dbReference type="InParanoid" id="A8PZB8"/>
    <dbReference type="OMA" id="WYEGRRV"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="115"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="406" mass="45786" checksum="A4193A3E4BFE9EE9" modified="2008-01-15" version="1">MGKLAFLLKAQVYAILACILYVLACLCLSHPILQRQYLFLHNVRIPMFAKFDTPDLYGTEVGQVRNFRLESTDNITLGAWHFLPEAFYNAKKQDLLSGESELLDDIYDEALREYPTFVFLHGNGLNRAASFRVRTCNDISKHMQANVIAIDYRGYGDSDGYPTEQGVIDDAYAVVQYAMRKGYNAETDRQQGLSLVGQSLGTAIATQCALRMYRERQHLDALVLLAAFKELRPMITEFRMGGIVPMLKFLDYLPQKEQLLDNVFIYNFKTLDALAEIMNSTNDPGAIVPPVMILMHAMNDRVIDIYHSRDIFERMLEITSATKLSSAYQIWSSSVPNLGYVNAIVSKTARAPERRGLIQGARFVLPRSASFSLVQLEKGGHDHLLNGNVDVLQLMLPAYMMGNSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q057</accession>
    <name>A8Q057_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730986.1">
        <property type="nucleotide sequence ID" value="XM_001730934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q057"/>
    <dbReference type="STRING" id="425265.A8Q057"/>
    <dbReference type="GeneID" id="5855293"/>
    <dbReference type="KEGG" id="mgl:MGL_1985"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1985"/>
    <dbReference type="InParanoid" id="A8Q057"/>
    <dbReference type="OMA" id="HRGRVMF"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13145" checksum="CF0AC69A811DCBF9" modified="2008-01-15" version="1">MLLPYREQPSTRGRLTTIAGIVLFLHAAYSAYEVLSQGKSIDLSTSTTAYESNVPLDIKFETLVAFVVLVVGCAMTTPKLRQMTWTARMRETDIDLVDARPSFATVYHRGAKLFAARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q091</accession>
    <name>A8Q091_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731000.1">
        <property type="nucleotide sequence ID" value="XM_001730948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q091"/>
    <dbReference type="STRING" id="425265.A8Q091"/>
    <dbReference type="GeneID" id="5855307"/>
    <dbReference type="KEGG" id="mgl:MGL_1999"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1999"/>
    <dbReference type="InParanoid" id="A8Q091"/>
    <dbReference type="OMA" id="FTCWDLG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="169" mass="18480" checksum="C322868CD3FA1DEF" modified="2008-01-15" version="1">MGVAFSSLWNSLFGQKELKICILGLDNAVVATAPTIGSNTETFEYKNLKFLLWDVGGQTSLRASWAQYLTSTNALIFVVDSNDRDRVSLARAELHRIAADENLDRAPILVWANKQDVRGSMSASELSDALNLSSFRDRTWQIFGCSALTGKGITSGLDWLATTLSDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0J3</accession>
    <name>A8Q0J3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2041</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731042.1">
        <property type="nucleotide sequence ID" value="XM_001730990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0J3"/>
    <dbReference type="STRING" id="425265.A8Q0J3"/>
    <dbReference type="GeneID" id="5855349"/>
    <dbReference type="KEGG" id="mgl:MGL_2041"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2041"/>
    <dbReference type="InParanoid" id="A8Q0J3"/>
    <dbReference type="OMA" id="VEQCKGW"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="348"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="815" mass="91481" checksum="9EF4410B7FC80649" modified="2008-01-15" version="1">MLVPLWRASVAPSWKTSYRRLHSCVGRLAEARTVRLESQRGTGRPVAHVLQEVCSGDAGSYVVARDNHGRPLSLGDSIDSTLSSLTFLPFEADDKLAQRTFWLSSAYVLTIALSRVCGPIICDIPSVKESSGAHADGISGYVVEFLRVPSLPTIELGEHSFRELRAQVEQSIQILVDEQRQVGAPKVSPEEVSSVDQFMKQLCAKSFDFQIARVNWKEAWSLFKHNPLLLRSIVSYGEQDALVPVVYMGHEACGVLPLNEVLLRRTKPIKAAKVLGWSTSSLPVAGMSDESTQPLLRVRGISFPSAQDLQQYSARMSELEKSDHRHLGIAQGLFFAHDSSPGSPFVMPHGMRLLRKVERVIRDLYDTFGYDEVQTPQLFRSSLWKQSGHWEKYREDMFSAQGFSCCGAHDDVFGLKPMNCPGHCVMFAHQPRSYRELPMRLAEFSPLHRNEASGALSGLTRVRRFHQDDAHVFCTPAQVATEIESMLHMLSLAYRVFGFGDRFELVLSTRPPNFLGQVEAWDHAEASLKEALDASGKPWTLNEGDGAFYGPKIDIRLVDAMGRKHQTATIQLDFQLPERFGLEYATSSQVPSTEQVRPGYARPVMIHRAILGSFERFLAILVEQCKGWWPFWLSPRQAVVIPAFSGNEETHQAVADYAAHVQYTLSGHTHETRETRSPFLSPTMAHQTLQVPSRTRFQIELPPQSLVPAGDTLGKKVRHAQLSRFNFFLIVGPQEAKNRTVSVRMRDEKAAPAWHAGEDAFHTMPCKIQDLTWAVIKATFPDRYAAHDAKMSLDLGTWTLPDLWRLFCVLDALHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1E2</accession>
    <name>A8Q1E2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1774</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730775.1">
        <property type="nucleotide sequence ID" value="XM_001730723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1E2"/>
    <dbReference type="STRING" id="425265.A8Q1E2"/>
    <dbReference type="GeneID" id="5855082"/>
    <dbReference type="KEGG" id="mgl:MGL_1774"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1774"/>
    <dbReference type="InParanoid" id="A8Q1E2"/>
    <dbReference type="OMA" id="NICPLAN"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="598"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="718" mass="80622" checksum="E81C4E3165502377" modified="2008-01-15" version="1">MHRSFVWRVAAHVPATWRPRKVARLEHAAEMSEALGSASPADTSLRYAFLRHSDDTSASSATQRMSPAARLGSSKVDGNAIVSLPEGLRTKLEALVLASNKDQLRRDAMHVSALDRAHHDKTGLLPRHSQHFVHALPRQRAVPLYVATHFAARYAILVRVFDEARRRLFSDRPDGWRPSRLVDFSSHTSEALWACAHVFGPEALHEYVAEARSGTMLKAHVDLQDDDCWKHMRTTFRVRGDKPHVYRDVPLASVQDSSLTHPPTTQPMSGTTIGVHAFGLSSLSSDVARERDVLRTWKSDADVLVFIEDATPRGFACIAAARSQLLELGRRSPDRTCHVVAPCPHDQACPLLHASSSDMPRRTKGIEVCSYAQMYQVPPFMRATLRLLRGDAVSQYCYLIVQRGPRPSLASATHTWAHAMPKHLARSTQDGVEALLQSARTGVLDQIRGGSQQRVVVSVDRDEHEIDGDHQHHTQQSGTDIDACTSALTSMGVDERRVMQTDAYAWPRLIRPPLKKGGHVTMDACCATGDIRRFTMPKSAGRQAYQDARKALHGELYAHMQDGSRATVSIRAPFSRRATAAAKTRRRSERARIPRTTQMPWRCPGKPRQRTTHHSRQSLMPPTSRVLPSKRFRSTCIWVRMHNTSHAQQVAYRSASRVVRRNDAELSWRPLTTRHGQHASRVGQIWRRHCVCGVTSPTHEALYTRYHDQEARLRAPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1S5</accession>
    <name>A8Q1S5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730833.1">
        <property type="nucleotide sequence ID" value="XM_001730781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1S5"/>
    <dbReference type="FunCoup" id="A8Q1S5">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1S5"/>
    <dbReference type="GeneID" id="5855140"/>
    <dbReference type="KEGG" id="mgl:MGL_1832"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1832"/>
    <dbReference type="InParanoid" id="A8Q1S5"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000015">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="47"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="371" mass="41026" checksum="E53EFAADCBE72CB1" modified="2008-01-15" version="1">MSSSTGKAQAPGYELPWVEKYRPRYLRDVVGNSATVERLRAIEEHGNCPHLLLSGLPGIGKTTSVHCLAHALLGDAYKEAVLELNASDDRGIDVVRSKIKAFAQKKVSLPPGRHKIIVLDEADSMTPGAQQALRRTMEIYAPTTRFCFACNQSNKIIEPIQSRCAILRFGRISDEELLRRLLQICEAEHVKYSDEGLAAVVFTAEGDMRQAVNNLQSTWTGMGYVSPDNVFKVCDQPHPLVVRDVLDKCYAGRVDSALDQLESLWSLGYSSLDIVTTLFRVVRTMDSLPEAVKLEYIREIGWTHMRTLEGVATLLQLSALVARLAKLVRMRVGAMHPSTNEHVAGHGPSAICAEVECGSEHPSMHTQRHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q262</accession>
    <name>A8Q262_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730693.1">
        <property type="nucleotide sequence ID" value="XM_001730641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q262"/>
    <dbReference type="FunCoup" id="A8Q262">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q262"/>
    <dbReference type="GeneID" id="5854989"/>
    <dbReference type="KEGG" id="mgl:MGL_2147"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2147"/>
    <dbReference type="InParanoid" id="A8Q262"/>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17865" checksum="DF3427CE1FA5795F" modified="2008-01-15" version="1">MAPKIDPNEVRIIYLRTTGGEVGNPAALAPKLGPLGLAPKKIGEDIAKASGEWKGLRVTVQLTVQNRQAAIAIVPSASSLVIKALKEPLRDRKKTKNITHSGNIPIDEIIEIARTMRYKSFGRTLASTVKEILGTCQSVGCKVDKKHPHDIIEAIDEGSIEIPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2R3</accession>
    <name>A8Q2R3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730427.1">
        <property type="nucleotide sequence ID" value="XM_001730375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2R3"/>
    <dbReference type="FunCoup" id="A8Q2R3">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2R3"/>
    <dbReference type="GeneID" id="5854734"/>
    <dbReference type="KEGG" id="mgl:MGL_2223"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2223"/>
    <dbReference type="InParanoid" id="A8Q2R3"/>
    <dbReference type="OMA" id="NGSMEAW"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="43465" checksum="EC9BECCB0E5165CF" modified="2008-01-15" version="1">MDAASGTSSGIFNILGKGLKLNSKEDISPYLAELEKIEPLHEIHLGGNTLGVGACQALANVLKTKKTLRVADMADIFTGRLITEIPDALRALCDALVDHEQLEEVNLSDNAFGGRSAEPMVNLLTNNRHISVLKLSNNGLGVSGGTIVADALYESAKHLKDGEKSQLRVVVCGRNRLENGSAIAWARAFAQHRGITEVSLYQNGIRMEGVRALCEGLSDCKDLEVLNLQDNTATLRGSRSVAKALPNWPHLRTLNLSDCLLKSKGGSLLFESLSMGRNKKLTTLHLQYCDLNRDALHKLGHAIEHHLSELKTLEINGNFADVDDDCISKIAASLEKWGHSEALDELDEMDPEGEEDEEDEEDEEDEEDDEEDVGEKEKKDPEADDLADELAKTHIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2V4</accession>
    <name>A8Q2V4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730448.1">
        <property type="nucleotide sequence ID" value="XM_001730396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2V4"/>
    <dbReference type="FunCoup" id="A8Q2V4">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2V4"/>
    <dbReference type="GeneID" id="5854755"/>
    <dbReference type="KEGG" id="mgl:MGL_2244"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2244"/>
    <dbReference type="InParanoid" id="A8Q2V4"/>
    <dbReference type="OMA" id="STYITEW"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="901" mass="97053" checksum="645D30A07706204F" modified="2008-01-15" version="1">MNDVSDKVGSLGPGAKPSSVPVPLHRVRFVDWSPSAITALALSPIPYQGSTSAARSVLAVGRDNGNIDLCMWCEDTSSGHASVAKGWTPVMTLLGDEHYKIESLAFTVSRDAKYGVVGDAYLRLFSTSGGSIVSEHFLPASIAYMGERSIFAQVPDPPKVPTRTLSSHGGAVWSMAASPTGKYLAIGCEDGVVRLIDVGGDAFEHVGTGMRVAPRMTRVASRILSLAWGPPRRNVPSKPKKHVSRQGAIHTDDSDDDEDDDDEDEDVEDEWIDTFLLGGLGNSTAAVWDVMTGQLRSRLTLLKNRQEHTIVWSVAVLRDGTLVSGDSTGRVTFFDARTRIPIPGATFQCHTAGADVLTLCVSADSCAVYSAGVDQKVVEYMHVGHAWTHTGTRRLHAHDIRALAIDPPLNFLSGPASVSTSQSTPTSMSNVPILISGGLDFHLVLTPASHASWRSKQQPNNPVSSSLSTSFADTTQRRVAFVPTNGRDSVVGVAPLKRWIMLRRERSIAIWALGDHESDPWHKVWELELSTRSNLGAAAISADGQFLAVSDLYETKLYSMQATPRRIASLGPAIHGRDVSAPGASALVFTPDSSRLVLCTVHGSYVHVVQLPASATDEPVLLKSFAQHRTKRFAAASAAGSNTPTSASASDGRVLSKGHVRPDLYTTTPLSEPANHKSSAATATELGSGREVLRDSYAPILLAVVSPDGQWLLTADAARRMHVFHLDTLSYQRALASPVCVPSSACFHPTHPSLLAIALPTNQVLFYDLEADDAPAWEASLRHEVDAQLGRIREPVVGCMWLSGNEGACSLVLYGPTWLCTARPLTTRTSVRKKRRNGQDDPTMGSGESAWSVRTTFKYQPLLYVGAMSTNEPELLVVERPYFALAQSLPPAFYRGAKYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2W3</accession>
    <name>A8Q2W3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 16">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_2253</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 16"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730457.1">
        <property type="nucleotide sequence ID" value="XM_001730405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2W3"/>
    <dbReference type="FunCoup" id="A8Q2W3">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2W3"/>
    <dbReference type="GeneID" id="5854764"/>
    <dbReference type="KEGG" id="mgl:MGL_2253"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2253"/>
    <dbReference type="InParanoid" id="A8Q2W3"/>
    <dbReference type="OMA" id="AQTYSEN"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP43243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="268" mass="30391" checksum="A3F56E200274B3AC" modified="2008-01-15" version="1">MAGARRKQSAARIQKVHVQRESQVTRENVFLFVPNLIGYTRVILAAISLYYMRGNPRVCTVLYCVSCILDAFDGKLARMLQQSTRFGAVLDMVTDRCTTACLLCYLTAAYPNFALIFQGLVTLDFSSHYIHMYSSLVSGSTSHKKVDSKTSRILALYYTNTRVLFVLCAANELFFLCLYLMAFYTRPLGLNIASLLPSALFDWVTADKMSWQFKLVYETIPSLTWPQIVGAISFPMCAVKQVINGVQFWKAAKVLADMDVQDRSRRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2Z8</accession>
    <name>A8Q2Z8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730482.1">
        <property type="nucleotide sequence ID" value="XM_001730430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2Z8"/>
    <dbReference type="FunCoup" id="A8Q2Z8">
        <property type="interactions" value="587"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2Z8"/>
    <dbReference type="GeneID" id="5854789"/>
    <dbReference type="KEGG" id="mgl:MGL_2278"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2278"/>
    <dbReference type="InParanoid" id="A8Q2Z8"/>
    <dbReference type="OMA" id="PDYHYLF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="212" mass="22971" checksum="97232C26666C47E0" modified="2008-01-15" version="1">MAGLSPDYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELEGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDESTFANVKQWLQEIERYACEGVNKLLVGNKADLTNSKAVDFESAKQLADELGIAFLDTSAKDATNVEQAFLTMAKQIKDRMGVSAMQNGSAGGAGKSTLKVGQGQNVQASSNSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q318</accession>
    <name>A8Q318_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730495.1">
        <property type="nucleotide sequence ID" value="XM_001730443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q318"/>
    <dbReference type="STRING" id="425265.A8Q318"/>
    <dbReference type="GeneID" id="5854802"/>
    <dbReference type="KEGG" id="mgl:MGL_2291"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2291"/>
    <dbReference type="InParanoid" id="A8Q318"/>
    <dbReference type="OMA" id="SMDPNLT"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="232"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="498" mass="53259" checksum="8A70BB211BA99D45" modified="2008-01-15" version="1">MSENALGFVSSSVPGRGSDQPSGIVSLDPLHSSQRPSPYPMHSSSGKGEGGSSSDLTFQSNPPPAAYAPASDEKKGMNDANSHSSSMDPNLTGARRSEGTQPGYPTMRQEQPPYRLDLLPTDPNLESNAPALHGDATEQDNVARAFPFLSNTMAGQDNDGRATIFPPNFSSVGSTATQDAAGAGALGYKKATDASEGADASSAFHSKSGRETSYDTLSPPEKKETPYSRSPSLRVTHKIAERKRRKEMKDLFDELKEFVPVDRGPKTSKGDILTKAVLQFQTLHREREQLIEALEAAHHELNQLRQMTGNADHASTGLSHHVYPHASAAAAPYLSRPPALAPPSRLPGSFLHGAQDQHLSRARGENKGDAPSHAAGVSMAPSPARTGEAFLSDLRLDRLRQPEEAVHANFKQLDHSPGVLDQSLGATTRSFQPESYQTGLVSSDLAEHQDNSMNTDASTAHAGRPVARDQPFSTAPRYVPRTDGDLIPDSTPGDATHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q320</accession>
    <name>A8Q320_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730497.1">
        <property type="nucleotide sequence ID" value="XM_001730445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q320"/>
    <dbReference type="GeneID" id="5854804"/>
    <dbReference type="KEGG" id="mgl:MGL_2293"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2293"/>
    <dbReference type="InParanoid" id="A8Q320"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1211" mass="127905" checksum="94CA77293ACB7188" modified="2008-01-15" version="1">MANYQAFQYPDYRNGYRVLVAKGAGDGIVRRGPENLAPALSYMQASGAVDPHGLAQLKSLARSNGKVGSDARARLAELGYEVPYLKSTKPTKKRTSKTAAKTGAPTTVQASSGVRSDVVMPGSAPLRLGPGVHEPSQNARAAAMAAVPPTTYGMSSKTAATKGDVPPLKKLSATLPVNSVTLTVTSSKAPVKTSKGTRKSRTVASRPVDISPIPVPVAPTLTGASGMVPVPRAPLPVTGAPASLTRTTSPTYESRTTTQNALLASQRMMLEHDRNTQAQLGVMSLASPRPKPKTKKKKVPKSSTMSTLFATARATKTNDTAAVSQLFMPLYSAPFLGFKHRDSVTGNKIAGLIKGLGSSSKEKNVKTEVGQELDPLLRPTIEHSARPSAGPVVYPGMSSLADQNVARGTVHHPTMGYFVEQDVAPATNGSAGHHAYQTIHHGTPPATNQVAEQLAGYDVGPHISTNQLSVQPTVMPTAAVPSAMDPTAPVHPIHERIPTYEQALTSVSDPHARLARRISQLRLNRDLPDVPEMQPLESGMPSSSSQEVQDIPVAKEMRHGVRGHNQSLEPVWEYAGADPHVVPVAPTTAGMTTSVGRSDGLTHPMWTTHASSDEYNVVPPGVSSDAYKMATQSEPEAEPGVGVYWRGRPIEYSSSATPVGVPAPHAASETHNKHAMHELLHGRHIKENDEEALLSKKKHRSAHQQDSSTPIATDTPGHFHEGPMDHLLHTSVTGEDLHKSNGHTHNTEEAMQTSDAKPTLLHAHTSGVRIPSASQLKAQQLVPVNELAPVTVPAVTTQASSVPQEVRMATTHSSLTQGGLAPPMPSTSVPSESMTATVDAAMPVTASSGAVSSAVPSESVAAPDNGTIPGTAVRTSAAPATAAPAIATSSVPAVPSNAVTAAPALDVSKPVVTTSSKTAAPMASKSQQDLGSFLSRQSMPASLASAQLPYPAIPIYTLAQVPASPAGAREHDPKVAHVPRLSATANKEQDGQVIMLRRANPVVGQEQELPPVQQTISDHETKAPLHRARSPIHAINHHAGQILLPVRSTSYPPATMLRLASNSEQPGQLQVQVRHSAQVPPTLPALSFQDKEFGLHAISLLPYDDMLWLPHVPSHDATPDTTNHLTSVLEQERRGSLSWSNRVPDLAPAYLRASLPSESRVTRVISQDPPTAEPVTEFSHGSSQPQKQHHPMAVVLDERNLAHSSPGAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3C3</accession>
    <name>A8Q3C3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730563.1">
        <property type="nucleotide sequence ID" value="XM_001730511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3C3"/>
    <dbReference type="FunCoup" id="A8Q3C3">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3C3"/>
    <dbReference type="GeneID" id="5854870"/>
    <dbReference type="KEGG" id="mgl:MGL_2359"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2359"/>
    <dbReference type="InParanoid" id="A8Q3C3"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="225" mass="25029" checksum="8F0565C059310AFF" modified="2008-01-15" version="1">MRLVGSHPLWGHYLWNAAPTLSMYLEEHDALVRDKYVLELGAAAGLPSIVAMKLGARAVVATDYPDPDLMQNLSFNLARYGSAKALGYIWGADCAPLKEHAPHGYDLLLLSDLIFNHQAHPALIDTLDRCLHPQGQALVFFSHHRPHMAERDLAFFTLASQRGYICEKLDEWLLTVRTGSTSKPPPSPLLPFLTAYANSSTLYISSRTAPMLVTFFHLTRIAHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3D7</accession>
    <name>A8Q3D7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730572.1">
        <property type="nucleotide sequence ID" value="XM_001730520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3D7"/>
    <dbReference type="STRING" id="425265.A8Q3D7"/>
    <dbReference type="GeneID" id="5854879"/>
    <dbReference type="KEGG" id="mgl:MGL_2368"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2368"/>
    <dbReference type="InParanoid" id="A8Q3D7"/>
    <dbReference type="OMA" id="QLWQQHA"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="691" mass="75991" checksum="2E6BF05E3855458A" modified="2008-01-15" version="1">MPSSFKSSRKTRSDTSQIKSRLEDYMDAEDLAEYRQLQTTSEYADQGPETNDPFLRLLSNSSSHLQAGSSQKGQAIMQLMGWKPGQGIGPLVSGDQRAQLIDLLERMHLASPSLLQTKHAAPHDEARRYKFPPPDTHMYEPPKDRRQSLGVESSSSRSDALQLALQQYHRAQGQQRRPQIGAAGMDSDDEDHVYAPGPSMQDSTLAYTEQDSATLVEDTEPPKPATQAKTHTPAVSGSVTWHDGRPLPPGFVLAKEPLPTERIWNPPPVPSNWVPDPHRVWLSKRSDPSNASNASRPSNANDRRAILGEAPPPGPPPMITEYIKVKAPSSDTSHLESPAARVTSPKQLKIHPLDPVTARRALAAFRGTGKDPRKDQRYQAYVASFLEGPVYLPPKGVALDAQQDEVDEFYQTACRHRPVHGDMAHRFTSSTFLQDESVGVQGGLQHASELQNHAQKHASQALESVPQTMESEPPSAAVRAARNGEFGALTRHVGVFYPPHLLCKRHGVPDPHPERDADSDDLDPTDLPDSNDRLSNVPGAPGTSSSWSSTTTSTTLTPMSSEVDDTPGIAFAPMSQELETAMEREMQASRPPMDLFKAVFQSDDDDDDNVEDDRSDRNKNSDSAGMRSRQSETTTHVTFTHKRAASGPKKKKRERAGPLTFSMEDDVDANDTSVTNKVPRRCHRSSHASNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3J9</accession>
    <name>A8Q3J9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730631.1">
        <property type="nucleotide sequence ID" value="XM_001730579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3J9"/>
    <dbReference type="FunCoup" id="A8Q3J9">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3J9"/>
    <dbReference type="GeneID" id="5854938"/>
    <dbReference type="KEGG" id="mgl:MGL_2427"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2427"/>
    <dbReference type="InParanoid" id="A8Q3J9"/>
    <dbReference type="OMA" id="WEEQFKQ"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF9">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="423"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="77061" checksum="08F7C0BB46E44286" modified="2008-01-15" version="1">MAFQSMISGAECSTSNNTLSQFLKHTQTDRSLQQDAMIGPTGISARPGFRTRPPPPAGVQDVDKFSRQRETPRAPVFDMHAMHAEMEALHARMPPQVRSSPNAWAHELQQQQKQPQPPLDPRIAHQLSAPHQIDSGPSWGKEFHADLSRMTEMRGTRGDTMSLRAPVGGGMGVGMNMGMGMYGVGQSGMFLGHGMLSNMSRPEAHANNPRVVELDHAKWDEQFRRLEEADAEAQAELPSQTDSSSRDQMREPDDNEALALKELREMEARLRDEVQDENPRFEELWNALKDPSLLEKSDDLAKWEEQLMEAVAAEDPINSTHPGGGLGPGVLGLEEEDGLGEAEALLRNELNEMDESGFPTLGAYEFEANNPFATHPAPYAEGIRLVENNGNLTDATRLFEVATQRDQDNISTDEIDRTRAEKSRAWQKLGETHAMNEHEEKAIQALVQALNIDASNLGAHLSLAVSYINEGYDQAANATLLKYMARSRPHLAPSNNFPPLETERTDPWARLNYVRDLFLKAAREDAAHGVMDPEIQVGLGLLFYSTSSYEQAKDCFQAALESRPNDWQLWNRLGATLANGGNSELATEAYHRALELRPSFTRAIYNLSVSCMNLGAHHEAAEHLLSALALQRSQSVPDTPASTTMPPPLSHARESESLWNTLRSIMTVMNRIDLANQCHVGSDLHVFRRAGFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3M8</accession>
    <name>A8Q3M8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2451</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730655.1">
        <property type="nucleotide sequence ID" value="XM_001730603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3M8"/>
    <dbReference type="FunCoup" id="A8Q3M8">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3M8"/>
    <dbReference type="GeneID" id="5854962"/>
    <dbReference type="KEGG" id="mgl:MGL_2451"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2451"/>
    <dbReference type="InParanoid" id="A8Q3M8"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000365">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="198"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="347" mass="37976" checksum="ED90F5ADE4D493B8" modified="2008-01-15" version="1">MVAHKQKVAIIGSGNWGSAIAKIAGFNTARHSDVFEPIVHMYVYEEIVDGRKLTSIINEDHVNTKYLPHAKLPENVVATPSPEEAARDATLLVFVLPHQFILNVCKSLKHALAPDAHAISMIKGVEVADKNISIFPDVIEKALGIPCAALSGANIANEVASGLFSETTVGYRPHQRALAEYYVKLFDTPKFRVGMIEDVAGVSLCGALKNIIAVGAGFVDGLGWGGNAKAAIMRIGLMEMRRFALEFFKDVRPETFTETSAGVADLITTCYGGRNRKCAEAFVKTGKPFNVLEAELLNGQKLQGTETTRDVYEFLQSRGKIEEYPLFKTIYDISFNGLDPKLLTERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q458</accession>
    <name>A8Q458_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyadenylate-binding protein</fullName>
            <shortName evidence="13">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_2501</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730119.1">
        <property type="nucleotide sequence ID" value="XM_001730067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q458"/>
    <dbReference type="FunCoup" id="A8Q458">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q458"/>
    <dbReference type="GeneID" id="5854426"/>
    <dbReference type="KEGG" id="mgl:MGL_2501"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2501"/>
    <dbReference type="InParanoid" id="A8Q458"/>
    <dbReference type="OMA" id="QQPGFMP"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000441">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000520">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000648">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="80"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="168"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="260"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="363"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="16">
        <location>
            <begin position="579"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="536"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP42905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="664" mass="71825" checksum="CF736E0A0EF4C22B" modified="2008-01-15" version="1">MSSDVAATQPAATANPPAETPAPVTSEATSSVPASTTESKQPENKKEKEEKEKPKAAASPAPTPATTTSSSSMNQGSVNTSLYVGELEPNVNEAILFEIFNMVGAVSSIRVCRDTVTRRSLGYAYVNFLNAEDSERALEQLNYTPIRGRPCRIMWSQRDPGQRRAGQGNIFIKNLDEAIDNKALHDTFAAFGKILSCKVASNEHGSLGYGFVHYESNDAAEAAIKHVNGMLLNDKKVYVGHHISKKDRQAKIEEARAHYTNVYVKNLDPAVTQEEFEKLFEKYGKITSAAIATDQEGKSRGFGFVNFSEHEQAAKAVEELNDTEFHGQKLFLGRAQKKSEREEELRRAYEAAKNEKLSKYQGVNLYIKNLPEDFDDERLQEEFAPFGTTTSAKVMRTPTGASRGFGFVCYSAPEEANKAVAEMNGKMIENRPLYVALAQRKDVRHQQLAAQMMQHNQLRLQQQQAAAAAAAQMYPGAPGMYYPQPPAAAGMGQFPGQVRPQYAPGIMQGMPPMAGQPAGPYPPGQFPPAGGMFPQGYRPPRPPRGAAAPPAGAPAGVPAGAGAPRTAAVPAQPVQPAQPEVLTAAALANASPEEQKQMLGEAIYPKIASTQPQLAGKLTGMILELPVGELLHLVEDDEALASKVDEALTVLREYESREGAEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4L2</accession>
    <name>A8Q4L2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730181.1">
        <property type="nucleotide sequence ID" value="XM_001730129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4L2"/>
    <dbReference type="FunCoup" id="A8Q4L2">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4L2"/>
    <dbReference type="GeneID" id="5854488"/>
    <dbReference type="KEGG" id="mgl:MGL_2563"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2563"/>
    <dbReference type="InParanoid" id="A8Q4L2"/>
    <dbReference type="OMA" id="YKNSCIT"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="388"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="552" mass="60482" checksum="589407B1FD800B63" modified="2008-01-15" version="1">MLPVRGLLHNVVCPAFRDGECEKQRAGGCLFSHDANLLEKRPHPDNATGAVKRAGPTLTTEGVPRKQARREAISESNLPTEAPALPRITSQRHPSTSKISLAQRQDGLKKVHTTLCRFYAPIWQHSDPRLQKLGREMAASDALRMEEDVFQHVNEYTYKTSSIAAAASVNKRATDVLASAVHEAAIALAGSETQGAKTSDSIGRAKSVLDACTETGSEADVQQKRQAQERRKKGRLTRERIIKAGFLCPKGDLEKLGYVTEIPPTWGAGSEKPDACGERPTCARCGIVYRVGPLGRVNTDNVNEQDPEACHFHSGRPRPEKLGMARARKVYRWSCCGRTVDSHTLGDDRCATGPHVFKEEGAEALHKRSAYVTWSDIPGQANAQEVLPVAALDCEMSYTTAGISVTRITLVDETGDVVFDELIRCPDGVSMIDLNTQFSGIHAEAYEAEAIFDLDTARRALAQYIGPQTILIGHGLENDLHAIRLVHTNVVDTCQLFPHPRGLPYRLALRDLVAKYLGRIIQAGGASVGHSSAEDAQMTLELVRWKWLDMCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4M8</accession>
    <name>A8Q4M8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2579</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730197.1">
        <property type="nucleotide sequence ID" value="XM_001730145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4M8"/>
    <dbReference type="STRING" id="425265.A8Q4M8"/>
    <dbReference type="GeneID" id="5854504"/>
    <dbReference type="KEGG" id="mgl:MGL_2579"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2579"/>
    <dbReference type="InParanoid" id="A8Q4M8"/>
    <dbReference type="OMA" id="CISEAWP"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13182">
        <property type="entry name" value="EVH1-like_Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11797" checksum="D04CF7BC84DA2AD1" modified="2008-01-15" version="1">MDLDARLQLNTRVLRRIDPCVTQLLSVASFAVYYKYENEWTKTSVEGPLFLYQRSEEPYFGLQILNRNDPENFYVGLSPLDDIELSKEFLIYRSHQQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Q9</accession>
    <name>A8Q4Q9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730228.1">
        <property type="nucleotide sequence ID" value="XM_001730176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Q9"/>
    <dbReference type="STRING" id="425265.A8Q4Q9"/>
    <dbReference type="GeneID" id="5854533"/>
    <dbReference type="KEGG" id="mgl:MGL_2610"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2610"/>
    <dbReference type="InParanoid" id="A8Q4Q9"/>
    <dbReference type="OMA" id="MAYGRIP"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="368" mass="41225" checksum="9353B7B01B62FB7A" modified="2008-01-15" version="1">MKHVRETRTLTLDYDTETGHRMINQYVVDSELGRGVFGSVKLAHDVYSRANVAIKIVQREAPRKLGVPYTPRQTDERVVREIRAMSLCLHPNVVQLFEVIDDPMSRKLFLITEYMQGGELVWRDELEQPTLSLTDARRVFRDILHGLNALHENGIIHRDLKPANILWTRDRTMAKISDFGSAYVRMTPSSVDELSSATDPVLARTAGSPAFFAPELCYGASDGPPITKAIDVWALGVTLYCMLFGHVPFDAETEYLLLECIVHDDYAVPTCMCCDRVIVGPRAPRWAPLYPNSQDLCGSGSGNTYSKSAGTDSRNESTKPAETNRSHSLSNEAHAVRHLLDALLDKDPATRMTLDRAMTHPWLVAVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4T8</accession>
    <name>A8Q4T8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730253.1">
        <property type="nucleotide sequence ID" value="XM_001730201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4T8"/>
    <dbReference type="FunCoup" id="A8Q4T8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4T8"/>
    <dbReference type="GeneID" id="5854558"/>
    <dbReference type="KEGG" id="mgl:MGL_2635"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2635"/>
    <dbReference type="InParanoid" id="A8Q4T8"/>
    <dbReference type="OMA" id="GLQAYGI"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="157" mass="17203" checksum="FC7737BAFAB5E93D" modified="2008-01-15" version="1">MFPMYRQMMSQATRRMQAQGARGYASASGDFAKNMTQRAQALGTSVFQAAERALGSYAEPIIYNLRVAGSLAKQVYIAEKLAPPTSVSQVTSAYQQIWSSISKASWWTHSLPAGEWRKIAVYGVEAVGIFSIGEIIGKRSLVGYKIKEHAGAHGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4V5</accession>
    <name>A8Q4V5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate carboxylase</fullName>
            <ecNumber evidence="4 13">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">MGL_2649</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="4 13"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730267.1">
        <property type="nucleotide sequence ID" value="XM_001730215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4V5"/>
    <dbReference type="FunCoup" id="A8Q4V5">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4V5"/>
    <dbReference type="GeneID" id="5854572"/>
    <dbReference type="KEGG" id="mgl:MGL_2649"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2649"/>
    <dbReference type="InParanoid" id="A8Q4V5"/>
    <dbReference type="OMA" id="AEACICY"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="20">
        <location>
            <begin position="32"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="19">
        <location>
            <begin position="152"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="21">
        <location>
            <begin position="567"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="18">
        <location>
            <begin position="1104"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="16">
        <location>
            <position position="747"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="777"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="779"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="912"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="17">
        <location>
            <position position="747"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="17">
        <location>
            <position position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP43053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1184" mass="131076" checksum="262DD41027028049" modified="2008-01-15" version="1">MAVSINKEQVVSHEFPSVEHLRDDLRELSGINCRRLMVANRGEIAIRIFRTAHELGLQTVAIYSYEDRMCGHRYKADFAYEVGKGLAPVAAYLAIDDIIRIAKENEVDMIHPGYGFLAENPEFARKVEDAGIAFIGPRPETIDALGDKTKARDLARAANVPIVPGTPGPISSYEAAEPFIKEVGFPVIIKAAMGGGGRGMRVVWSMNDFQASFERAVSEARSAFGDPTVFIERFLDKPRHIEVQLLSDGQGNCIHLFERDCSVQRRHQKVVEVAPATQLDDSVRQAILEDAVKIARTAQYRNAGTAEFLVDQQNRHYFIEINPRLQVEHTITEEVTGVDIVGSQIQIASGATLKDLGLSQEKLAVRGCAIQCRITTEDPEAGFQPDTGRIQVYRAAGGTGVRLDAGSGFVGAQITPHFDSLLVKVTCRAATYEMARRKMIRALVEFRIRGVKTNIPYLVRLLRHHYFVEARTWTTMIDDTPELFILWHSANRAQKLLMYLADLYVNGSSIKGQVGEPGLWREAHRPTIFKDGKPVDTSKPMLQGWRNIIVNEGPEAFARKVRAYKGTLIMDTTWRDAHQSLFATRLRTIDILNIARETSHALHNAYSLECWGGATFDVAMRFLYEDPWERLRAMRELVPNIPFQALIRGANAVGYTSYPDNAIYEFSKRAVENGLDIFRVFDSLNNLDSLKLGMHAAKVAGGVVEGTICYTGDVADPSRHPKYTLEYYLKLVDELVATGNLHVLGIKDMAGLLKPVAARLLVGAIRAKYPDLPIHVHSHDTAGIAVSSMLACAEAGADVVDVAVDSMSGLTSQPSMGAVVSSLEQMELGTGISHENIQRLNLYWSEVRQLYQCFEQNVKASDSSVFDHEMPGGQYTNLMFQSQQLGLGSQWSEIKHAYMEANMLCGDIVKVTPSSKVVGDLAQFMVANKLSAKDVEAKASELDFPVSVIEFFQGFLGTPPGGFPEPLRSHIIRNKERIDGRRGASLPPLDFQKIKDDLTVKYRRVMSDCDAVSWAMYPKVFEEFQDFVDAHGDLSRMPTRYFLGKPKVGEEMHIPIEQGKVLIVKLLGLGPMNDSTGMREVLFELNFGPRSVCVKDHSADVEEVHHDKATSDPGSVGSPLAGVVVDVKVKEGDAVKRGDALFVMSAMKMETIVSAPIDGKVSRLAVKLNDSLSQNDLLCEISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Y3</accession>
    <name>A8Q4Y3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730289.1">
        <property type="nucleotide sequence ID" value="XM_001730237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Y3"/>
    <dbReference type="FunCoup" id="A8Q4Y3">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4Y3"/>
    <dbReference type="GeneID" id="5854594"/>
    <dbReference type="KEGG" id="mgl:MGL_2671"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2671"/>
    <dbReference type="InParanoid" id="A8Q4Y3"/>
    <dbReference type="OMA" id="MNIGPKT"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="794" mass="90130" checksum="83D0EA93B8E8A668" modified="2008-01-15" version="1">MSRMTNNYGGLLAEYLKSPDDLAKIPSLRRKLVQEHASLSAKLKMGAKDQLEATREGLLQLQSTRREIAGIQEIFSQIEGLCQDPRDGNRPDGTQSFRLISELSQLRRALVQTEEIHQKFEAMSQDVQMLSKVLRQYQRDIMGPAPELLALHYKISRWETFRNEALHLAGTSARDTREQLIAMLAPLEDLLDAFEYYIISLFAHTLNLARCGHQSVVVCLVKIMERENQEDERTAAIRFAKHAKIDGAARFHGIATYGHSIKLYWHKFQDTLRVSALQRLLKAWTSLREPSPAELYSQIDWLYDELDQARAWLVPLFPPTCNVFKMYVQAHHRALGELLQAQMPLDEVDAASLLELYHVAQEHETRLLKKKHGIDASWLEPSLLGGREQNIMDDYTGLITRKMDDWTATLMYDEVNAFVHREKAPEETSEGMYQLSCCVIFFRMMNQQLDLAAETKNADLLLRVVDHACGVMHQTQATWMRTAQQEFKKQTTAKQPEEVNGGLVEYLIALANDQLASADQCEQLLHRLVNQVPSENRGRVRELLDNALNGFLDISKHCLQLLVDIVLFDLRPAFKDMFTFPAWYIEGTTAMITETVRDYAGDYAARLDPNLYDVLSDDLLMRLLAAYLTALRRSARLRMPKAAERFGVDISELSNLISFMRPGDEATSRVEVLHMIHAILSSSSSMVFLPYWTFAKAHGPNLAFIEAVLRARDDMDKNDVTAVLESAKRKIRQENLPDVPEGGPTIMSAVSQTQASAFSNLFSNWHAGPDGDTWSALAQSAQNYLGAAGWRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q539</accession>
    <name>A8Q539_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730333.1">
        <property type="nucleotide sequence ID" value="XM_001730281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q539"/>
    <dbReference type="FunCoup" id="A8Q539">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q539"/>
    <dbReference type="GeneID" id="5854638"/>
    <dbReference type="KEGG" id="mgl:MGL_2715"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2715"/>
    <dbReference type="InParanoid" id="A8Q539"/>
    <dbReference type="OMA" id="IREWDRY"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="9">
        <location>
            <begin position="406"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="753" mass="86550" checksum="19101132326A8DE4" modified="2008-01-15" version="1">MATRAADGTNLPPSNDIVATWNFLESGIDVMMTRLTEGMSYERYMQLYTAAYNYCISSGMGGTSGMATGAHLVGGELYMRVANYFLQHLQGIYTRLAPLSGEELLRAYSAEWERYTNGANFVHRMLIYLNRHWVKHEREEGRTDIHTVYTLALVQWMKHIFVPIQRGHALMDAVLYQIEKQRHGELVPTALLKCVLDSCVSLGIDDVDAVRLNLDVYLREFQQAFLAATASFYKAESAEFLAHNSMTDYMKKAELRLEEEENRVEMYMHSSTRAPLMEVCRAELVSAHQDLFWQEFKTLLENDMTEDLARMYTLLSQLPGDLDPLRVQFEAHVKASGLDSVSRDMEENSDVIEPTTYVHALLRVYHDSVRIITKSFDSEAGFFASLDKACRVYMNRNQATGVSASRSPELLAKFIDALLKKHSRGGDEESSLDESLDAAMIVFKYIEDRDYFQKFYAKFLSRRLVSFASASTDAEESMIARLKEACGFEYTSKIQRMFTEAGLSKELNDRFQESGMLQNKELSFYSFVLTSGVWPLQAPQTDFLVPAELQSTYDEFTRFYHKQHTHRQLAWLWHLSTNELHTNYLSRKYIFTTSTYQTAVLLLFNSETVLTFDEIAAATRLDKSTLHAALVPLVKLKVLHLLDDSYSLNMDFKAKKVRINLHIPVRAEQKVESAEVARTVHEDRKVLLQATIVRIMKARKTYKHNLLLNEVILQLQSRFHPKVPDIKKAIDTLIEKEYLQRVEGEKDTYSYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5A7</accession>
    <name>A8Q5A7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730384.1">
        <property type="nucleotide sequence ID" value="XM_001730332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5A7"/>
    <dbReference type="STRING" id="425265.A8Q5A7"/>
    <dbReference type="GeneID" id="5854689"/>
    <dbReference type="KEGG" id="mgl:MGL_2766"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2766"/>
    <dbReference type="InParanoid" id="A8Q5A7"/>
    <dbReference type="OMA" id="KELEYEC"/>
    <dbReference type="OrthoDB" id="2564267at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="916"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1112" mass="123482" checksum="16756A33FB67AB33" modified="2008-01-15" version="1">MHSGSADLMIRPHLKASSSDGQYTKPSKKEQRKLRRRRQLAAALIEADNDDIERRVNYLTQYDAASSDIPALLSVAKFATQSVMLSAAATDQTQENDRPVYTYPLNTMQELSRKFLGLSAQWEGDDSSHDAANDDSLVDLYADEDSKLGRVEIGHLTFGSPLTHVLHDVQDIQTSSNQVQASTPVHSPRRTKPPHLSASVSMPQLSQKALTDSRGEFLLQRIQHLQEHPEPTPNPDISTSSQEDTSATFEDVGSASSERHPAKHRTSSLSLSSKASLSGIQPISDSTLFEQRNALGIQLGSDSEAFFSFRQRVLRGKEAARNPSGRRHSLSVSGWPGEMHSVAEEAGFLYDKPLDGLEPNPVQFGQQEPLSDMENKHDSLHEEGDKHYDGSHGTNNNDGSTHNHQNNHVTLRAKQWAQKFNTFRSLDKKRAKLSNVHTDPSDTKLAVSSEYPQLDGLSPVLDVPETSAPNSAAVSTPKDDALTGVSLHSPMTNPYDMASDRAPSSANTLRPNELLSPSASLSSSPPSPYPSAPQSSSLQAPPSAVEQMPLMNAKDSSFAAGEPIQASSSFYMNDANTLRHGPSWIPTYICIPMPLENLPIDVRDTQTDDDDKAFFAPHGAFILERGVILPSIQKNAGTYGPVQVPVNIGRRVLHPSTALFRNVLVQRDDEREGWGWERHTNASRYFADLQADDDDSDDELPLMDVRIQARDEWLAQKRQHRERVRRRQAKRERQRLRVQALEKGVHPSEYGVSEQSSDDGNQSGSDTTIDDGDELSEESDPERPWVDDKRPAGRLYGSSLIEMAMRQKQEQQQTARYYGRESMSANHMFTNDTKARMQRLFGEVSLWDEEMQRHQTSNQSPPAVAGTSVSMDEPVEPMLEPGAASAIVYPAADEVLVMEEAALDCEDDHVGDTWDDTSSSSSVSTSQSHNQDEQPRQKRLTYPIRRMARYSRNDPNRPRWLEKGEDDVPLAALRDDAEKYFSSSDEDVEPLGARHPQAEVIAEKEALIRRLQEENAQARMLLLRSSMQMHMPMPYMPWMMPPWMMPSISSEAHSLLGDDTLAATAAAATEHGELTDDVPVSYMYDPNVHAHGMYSATPAPVAWSVDDAHASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q604</accession>
    <name>A8Q604_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2837</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729851.1">
        <property type="nucleotide sequence ID" value="XM_001729799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q604"/>
    <dbReference type="FunCoup" id="A8Q604">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q604"/>
    <dbReference type="GeneID" id="5854158"/>
    <dbReference type="KEGG" id="mgl:MGL_2837"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2837"/>
    <dbReference type="InParanoid" id="A8Q604"/>
    <dbReference type="OMA" id="IAFIKHE"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="353"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="512"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="642" mass="70370" checksum="47F73246505097CB" modified="2008-01-15" version="1">MTTKSNAPTKVPSSLPVPFAEPHGTNGSFDTELDAMFAAAPIPSTTARPVKPQIPGQPEKENEELTTSDLNSASEEEEETDATGGAEEENGQVDDDVEADEDISDEDMDEEKAADMVLRGHFDKKRKSKVILEDEYESDEARSKRTIFLGNVPIAALTSRAVRKELLRHILDMSPYPTCTHVMSLRFRSVSFRAPTTDLSQSTGDAPSSQGKAKRRERARKFRELKGVGTDGDKTTQPPLTSQQKRKIAYIQQDVNERADAVNAYVRIGDPALVHQHRKATEPLDLRLTGAILSTLLARALDNTTFHERHIRADVVRPLAMHEIIEAGLDKIRTADGTPLSHASAVGATDPKRTVFVGNLDFEAHEEDVRALFERLVREERGPPPAVPISSLRLDDTPTVASTSSMAPSSLMKPGEWVQSVRIVRDRATQLGKGFAYVKFLDPMCVDEVIALAEAEEAFVAAGRPQGRARSTRTGAQGAASGAAGVKSISLQEGQEFRRRVKLNKRALRVSRCKSITGDERKRTRSQHGSDPSASRPQTPPKRPIPESLARARASGAPTPNGSSPHVHAMPEKARFLSSLSKEQRALAKKSDPDRQARRAQKKLDKRKAQKVASSMGRGRERVALPKRGTAKKITRAKSTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6A0</accession>
    <name>A8Q6A0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729910.1">
        <property type="nucleotide sequence ID" value="XM_001729858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6A0"/>
    <dbReference type="GeneID" id="5854217"/>
    <dbReference type="KEGG" id="mgl:MGL_2896"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2896"/>
    <dbReference type="InParanoid" id="A8Q6A0"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="112" mass="13587" checksum="B0B245C3E0A06A5E" modified="2008-01-15" version="1">MRNQQVDLKPWYTQPKTSIGFDHKRDEHDLERAKRCDEKRKHDEDPLETVRKYVKMKPESSGEAEYMKNNRSLQEERHQREAHEAERAAALKKQRSFFRTRARALREARVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6B5</accession>
    <name>A8Q6B5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729925.1">
        <property type="nucleotide sequence ID" value="XM_001729873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6B5"/>
    <dbReference type="STRING" id="425265.A8Q6B5"/>
    <dbReference type="GeneID" id="5854232"/>
    <dbReference type="KEGG" id="mgl:MGL_2911"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2911"/>
    <dbReference type="InParanoid" id="A8Q6B5"/>
    <dbReference type="OMA" id="VCDFYVQ"/>
    <dbReference type="OrthoDB" id="10253390at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="99"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="764" mass="87401" checksum="3EB36348048FCC04" modified="2008-01-15" version="1">MSRVALVMSGIAGGVALLALICQPVRQALVFSYNCFLQPLGKTKNQAERLDRFYEHQAGVYDATRTGLLRGRKTMLKLCAAEMRQLREKEPHRKLVWADIGGGTGWNIEQMDKFFPVAEFDQIYLIDLCEPLLKVARERFKRLGYKNVQALCQNAKDFTLPGLDPEQKVDLFTCSYSISMIPPFYAVLDRINEFLDPKVGVFGVADFYVSSSESTSDQLTLVGGSIMRRCHWLNSWFWRHWFALDHIELHPARRDYLEHKFGTLKCFNGRNNFVIPYLVQIPYYVWLGVSRQRDTSNAATAFEVEAGNHVIVPPSFPDVARERLSQSKTNNMSTEGAIERLKGDSSMQWPQSSFHYQKKLWRLPFVDDRFSDMFRTWIYGFTWEDPYVDMEHLDLGPSDSILCITSAGDNALHYAATAKPHRIHAVDMNPCQGHLLELKLASIATLDYATFWSMFGEGKIDNFPDLLDQRISPLLSSHAYQFWKSNNKSFERAFYFRGYSGHALRLAKAAFNLMGAKKDVVAMCTTKDLAEQKRIWDTKVRKTIINETLIRVFLSNPAFLWNALGVPINQFDIFKNEGCSVEQFAVDTLDPIPARSLMSTDNYHYRLCLMGNYSHESCPLYLKEDAFNALKADNAKALDCFRLHTDAIVSVLRGMQDASLTRAILMDHMDWFNPVEDSVPMPSLDAARNEEDKSVADLDREVVELARVICKGGAVFWRSAAKHPWYSQRFEKAGFRVAPIHIRETGKPIDNVNMYASFYKAVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6E7</accession>
    <name>A8Q6E7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729957.1">
        <property type="nucleotide sequence ID" value="XM_001729905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6E7"/>
    <dbReference type="STRING" id="425265.A8Q6E7"/>
    <dbReference type="GeneID" id="5854264"/>
    <dbReference type="KEGG" id="mgl:MGL_2943"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2943"/>
    <dbReference type="InParanoid" id="A8Q6E7"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="6">
        <location>
            <begin position="54"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="211" mass="23941" checksum="0FDDF3FDAAA839B3" modified="2008-01-15" version="1">MKSTLEEARQATLRNQQLEQEMKERNIIIGKLRHEAVILNEHLKNALSRLRRESSEDCVDRRLMSNLILQFLSMPRADTKRYEILRLIASILQWDDAEREKAGLQRQSDRSHGYGFLGLGGLMSSPRKASTAETQSSADESVSNLFVEFLLSEVERSKTDPQQTSGPSFGQGQEDQFQLQPQFDHQHPPSPPSQLHHSAQHQPESGPPTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6K1</accession>
    <name>A8Q6K1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TPPC8 first Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730004.1">
        <property type="nucleotide sequence ID" value="XM_001729952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6K1"/>
    <dbReference type="STRING" id="425265.A8Q6K1"/>
    <dbReference type="GeneID" id="5854311"/>
    <dbReference type="KEGG" id="mgl:MGL_2990"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2990"/>
    <dbReference type="InParanoid" id="A8Q6K1"/>
    <dbReference type="OMA" id="ICTHMAT"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058541">
        <property type="entry name" value="Ig_TPPC8_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24545">
        <property type="entry name" value="Ig_TPPC8_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 first Ig-like" evidence="2">
        <location>
            <begin position="404"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1032" mass="114561" checksum="E98912DA75558178" modified="2008-01-15" version="1">MSRSMALLEEVRKTYGLDCAIVHVNSAQEPDPLVHAIYTCKMHASMSRMHADDQRSSPMTSSAAKAADDSTTIAASQEALKGARLSMLDVQRIQAYVREMITKSLVPYLERTVQQLGEHIASQRRGLTGRLLGAGRKWFSSRPSSDQVLSDHGIYPTTSLPFQTRRLADMAMHIRDYRLAAQMYEAARRDFQADQATLHSACAGEMYCLAQLLHATTTPAYHNSLTQLFLHVCDEYVSIRVGEFFALRGAVLYGTMQELVSDYEHMAMAYMRAAEFTDEIVRALLLEHASLAYLRMSRPHMRRSAAALLLAAAQYESCGQNELALRCYMRTADFYKACNTPLHDHSLFKMAHLVHSSGRMDDALAYLLPLLHGSLPELDAVLLHALETVTKYAHDTRVTLPVPLFQPGASYILQSTASDNGIPCVREKEPFHVQLTLRNPLGVEVALTNVALHFVSAHKNGHASSAQVNALGRLDDLTLGPHERRSVVAAAYVHDAKAEYVRLSHVTYTLAGMLHVQQDMSKHGKRLNSTLEQRRTRMYAPDLSLLARVRQDMPHVDMHVDVPTHAYVGELVHIRMRLVNTSVSNISSLTIKSIPAHMQCSCLTASELELPWNPSSSFTHAAPLPALQGGQEHEITFVYHVLSPGEQVLTWVLCYENAAHEHFEARMEQSLIAHVAMQAVARVRLTARREPLYGLAIDTKNCSSDTLTCDGITFVSPLWKAHTEASLPATLTAGDVLTTFVRLQPTLLPQNADIVTHMLNELHRYLSGKAYDSSLTTSMQIATHVSQLGHAHDPALTSMPSLYSASRYIQRQTELDRLYNFMPKRLAQRAFPLIGPNDVDLVLHWHDANHRRGQTLLCGVKVGIQHCTAQDMASLKTLLDLHGPSHAMYEETAREQAMIRGRLRHTPLGSVGMPLSVYANLDSVMLDQVPAAQSITLFIRNEAPWPLSFSLTLVQPTSQAGFAPWLGKLSHSGTVGAWTSCPIDVCVLVTEPGTFQLGNVQCQATLYDKEQAIKSWNVISAMDVLLVARLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6N7</accession>
    <name>A8Q6N7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5'-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730033.1">
        <property type="nucleotide sequence ID" value="XM_001729981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6N7"/>
    <dbReference type="FunCoup" id="A8Q6N7">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="GeneID" id="5854340"/>
    <dbReference type="KEGG" id="mgl:MGL_3019"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3019"/>
    <dbReference type="InParanoid" id="A8Q6N7"/>
    <dbReference type="OMA" id="TIFESWE"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25433" checksum="16001640B749284A" modified="2008-01-15" version="1">MVDTVGMGYTERRKINEEIVAERIGFRDGFRQMLESVKHPFEEMKELTRRDVKLDPGFKEFHAFAKENQIPIVVVSSGMTPIIRAIFSNLIGEEEAGKLDIISNDVEFTDAEKEGKTWQIKYRHPDNSYGHDKSLSILPYRDLPNRPLLFFAGDGISDMSAARHADVLFVKDKKDNDLARYCDNNKIGYHLFKDWTVPKQMIQKFLNGEMTLDELVTRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7D4</accession>
    <name>A8Q7D4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729781.1">
        <property type="nucleotide sequence ID" value="XM_001729729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7D4"/>
    <dbReference type="FunCoup" id="A8Q7D4">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7D4"/>
    <dbReference type="GeneID" id="5854087"/>
    <dbReference type="KEGG" id="mgl:MGL_3325"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3325"/>
    <dbReference type="InParanoid" id="A8Q7D4"/>
    <dbReference type="OMA" id="HIMDSVE"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="279" mass="31496" checksum="0B6CBE48755433EA" modified="2008-01-15" version="1">MGKSEEILGKALRVFNIPRERVVIMSKCYFGVATDGTMPPILSMASNDGDMVNRVGLSRKHILDAVEASVRRLGTYIDVLQIHRLDRETPKEEIMRALNDVIEKGWVRYIGASSMAAWEFQQLQHVAEKNGWHKFISMQNFYNLLYREEEREMIPYCKATGVGIVPWSPIARGVLSRPWDARSTKREGTDAVLHRLIRSRETEADKAIVNRVEEIAKKKGTSMAQVATAWCLSKGANPIVGLSKMDRIDEAVAALQVSLTQDEIEFLEQPYMPKAVAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7G6</accession>
    <name>A8Q7G6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729788.1">
        <property type="nucleotide sequence ID" value="XM_001729736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7G6"/>
    <dbReference type="GeneID" id="5854094"/>
    <dbReference type="KEGG" id="mgl:MGL_3332"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3332"/>
    <dbReference type="InParanoid" id="A8Q7G6"/>
    <dbReference type="OMA" id="NISQRTA"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="881" mass="92145" checksum="1EABAA944B9EBF2E" modified="2008-01-15" version="1">MTIPNKSCQSSTTPKPPTPNSSPKKSCQTVPSVMASTTKVVDSNGRTHTSATTFTTMVLESSCRSKTTPKPPTPNSSPKKSCQTVPSVMASTTKVVDSNGRTHTSATTFTTMVLESSCRSKTTPKPPTPNSSPKKSCQTVPSVMASTTKVVDSNGRTHTSATTFTTMVLESSCRSKTTPKPPTPNSSPKKSCQTVPSVMASTTKVVDSNGRTHTSATTFTTMVLESSCRSKTTPKPPTPNSSPKKSCQTVPSVMASTTKVVDSNGRTHTSATTFTTMVLESSCRSRTSPRKPHETAAMPHSHRTSSCKTETSVVTSMTTSVDSRGETHTRATTMTTMVPESSCRSMTTPKQTKSCSSMTSVIETDVISTDSKGRKHTSSTKKTTVVPASSCVSTTPHTTKRSTVKPSKKSTTSCSSMTSVIETDVISVDSKGSTHTSSTKKTTVVPASSCVSTTPHTTKRSTVKPSKKSTTSCSSMTSVIETDVISTDSKGRKHTSSTVKTTVVPASSCVSTTPHTTKRSTVKPSKKSTTSCSSMTSVIETDVISVDSKGSTHTSSTKKTTVVPASSCVSTTPHTTKRSTVKPSKKSTTSCSSMTSVIETDVISVDSKGSTHTSSTKKTTVVPASSCVSTTPTSTTRSTVKPSKKSTTSCSSMTSAIETDIISIDSKGSTHTSSTVKTTVVPASSCVSTTPTSTTRSTVKPSKKSTTSCSSMTSAIETDIISIDSKGSTHTSSTVKTTVVPASSCVSTTPTSTTRSTVKPSKKSTTSCSSMTSAIETDIISIDSKGSTHTSSTVKTTVVPASSCVSTTPTSTTRTTTRASRSSNTSPTTNTNKSKHTSGKSVWRSGTVSCTEPFQPVFTRFVPPYEHTTTTSFVDCEIINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7H9</accession>
    <name>A8Q7H9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729529.1">
        <property type="nucleotide sequence ID" value="XM_001729477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7H9"/>
    <dbReference type="FunCoup" id="A8Q7H9">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7H9"/>
    <dbReference type="GeneID" id="5854097"/>
    <dbReference type="KEGG" id="mgl:MGL_3073"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3073"/>
    <dbReference type="InParanoid" id="A8Q7H9"/>
    <dbReference type="OMA" id="WKKGNTF"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="304" mass="33412" checksum="DCBF659B7F1EE1D4" modified="2008-01-15" version="1">MADENVTDQKFMNDLGHIIDVHNQYEDQYKATVQKITSRMSKKERNTAVDAASYGYGPLAFLRFPQGTGHLAFGGEMQPGMFRSIHDRKIANPAPLGFCGFALSTFVLSLINVGTLNLKNLSILVCLGFVYGGLIQILSGMWEMAIGNTFGATTFTSYGAFWISYALLIMPSKSLNIMEAIKVAEGGYGELQTVGLYYMGWFVFTTLMTMLTLKSTIAMFLLFFSLDLCYLFSGVSYLYNDGNEPQAALLRVSGAFGLVASFSAWYNAFSGVADNTNSLFVLPALHFPWTSGSSIKKLDESHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q814</accession>
    <name>A8Q814_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729636.1">
        <property type="nucleotide sequence ID" value="XM_001729584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q814"/>
    <dbReference type="STRING" id="425265.A8Q814"/>
    <dbReference type="GeneID" id="5853942"/>
    <dbReference type="KEGG" id="mgl:MGL_3180"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3180"/>
    <dbReference type="InParanoid" id="A8Q814"/>
    <dbReference type="OMA" id="FPHCDES"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="12"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="410" mass="45615" checksum="4C52BD9653B9AE58" modified="2008-01-15" version="1">MPSSSTVLDEPYEIVAQVGEGTYGQVYKASAGRHGRLVALKKIRMENAREGFPVTSMREMKLLQALRHENVIRLHETMTSRTGSVYMVFEYMEHDLNGILVHPDVDFSASHVKSLASQLLHGLAYLHGRAVLHRDLKGSNLLLNSQGTLKIADFGLARTYSKRKPGDYTNRVVTLWYRPPELLLGATRYGAEVDAWGAGCLFLELFRRQAVFQGRDEIHQLHVITQTLGPLTASAWPSLQHLPWYELMRLEDSNHADTTSAPVATALTNTNDTPTDHDRDVFVQQFGSVLSHGAMELARGLLTYDPDQRWSANDALGCAYFTTEAPVPEKPAQYVSMKCDVDRCINQHSQAFSHTRWRMARNAVETCLATCPSSNAHTCAQRVSTTFHVTRSTPHAAGARVDIGGVWPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8R7</accession>
    <name>A8Q8R7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729300.1">
        <property type="nucleotide sequence ID" value="XM_001729248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8R7"/>
    <dbReference type="FunCoup" id="A8Q8R7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8R7"/>
    <dbReference type="GeneID" id="5853834"/>
    <dbReference type="KEGG" id="mgl:MGL_3335"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3335"/>
    <dbReference type="InParanoid" id="A8Q8R7"/>
    <dbReference type="OMA" id="HELIYNG"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="2"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="298" mass="31752" checksum="BBF8EA31D352509F" modified="2008-01-15" version="1">MGTVIEKAPDAGSSVKVGDRVAGTVHGGWEVGVGGFAQYVVTTPEYVVAVPDSMSDEEASGLGVAGITALFGLFQNKQLGLPEPSGTELPPVDPKLKVLVWSGASSVGQFVIQMARAIGAYVIVTASAKHLDWLKSLGASELYEYSNSETPKRIAEAHPDLKYAFDTYSMNGSQAACAASMSKTEAGKIVSLLPFDHGTVTEANPMAKCTLFLLPSVSCMGIRTFSAEFKPYYCPDDAKYIVHVCRGKDGLYYRLLSSGLVKPNRTSPQTGGLSGILSGLDRMRHNKVSGEKLVYKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q908</accession>
    <name>A8Q908_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729350.1">
        <property type="nucleotide sequence ID" value="XM_001729298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q908"/>
    <dbReference type="FunCoup" id="A8Q908">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q908"/>
    <dbReference type="GeneID" id="5853657"/>
    <dbReference type="KEGG" id="mgl:MGL_3385"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3385"/>
    <dbReference type="InParanoid" id="A8Q908"/>
    <dbReference type="OMA" id="MSYQQER"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="361" mass="38417" checksum="439157DD37CE2712" modified="2008-01-15" version="1">MESYLVDERNTSMAAVRTACSITTKVFKTLTTAESVTKKDKSPVTIGDFSAQATINYILNKKFPHDGIVAEETSSDLQGEAGKTNRDKVCALVNEALQASGEIQAPLSDDDILATIDKGAFQGGRQSRFWTLDPIDGTKGFLRGGQYAVCLALIVDGNVELGVMGCPNLPCDKSKPKPADGEIRTSSMEGLGVMFVALRGHGAYSVPIDDVHAPLVPVCMRDLQGDIRQATFCESVDAGHSSLGTNARIAELLGMGDRHVRMDSQAKYGSISRGDGDVYLRLPVGDGSYQEKIWDHASGSLLVEEAGGKVTDIAARPLNFGLGRLLSANKGVVACQANMHAKVIDAVAQALEEEGRASLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q970</accession>
    <name>A8Q970_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729389.1">
        <property type="nucleotide sequence ID" value="XM_001729337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q970"/>
    <dbReference type="FunCoup" id="A8Q970">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q970"/>
    <dbReference type="GeneID" id="5853696"/>
    <dbReference type="KEGG" id="mgl:MGL_3424"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3424"/>
    <dbReference type="InParanoid" id="A8Q970"/>
    <dbReference type="OMA" id="DEPEFQD"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="146" mass="16119" checksum="E7821C52F061A566" modified="2008-01-15" version="1">MSFEAGDENEADYFDEGVDFDAAEMDEPLNEEAGAGDDEDHFGDNEVVHSSADGNIPMNMDTSGKANSERITTPYMTKYEKARILGTRALQISMNAPVLVPTEGEMDPLAIAQKELLAKKIPLLVRRYLPDGTFEDWSVSELIITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q996</accession>
    <name>A8Q996_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729404.1">
        <property type="nucleotide sequence ID" value="XM_001729352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q996"/>
    <dbReference type="STRING" id="425265.A8Q996"/>
    <dbReference type="GeneID" id="5853711"/>
    <dbReference type="KEGG" id="mgl:MGL_3439"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3439"/>
    <dbReference type="InParanoid" id="A8Q996"/>
    <dbReference type="OMA" id="DRNLAWW"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725514" description="Transmembrane protein" evidence="5">
        <location>
            <begin position="27"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="434"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57056" checksum="529F2B633F343446" modified="2008-01-15" version="1">MRQMTTTACAVAVVLALLGCVLRVHADMNYHPVRLHGRGSNMQSKFIVPSKVIDVSSIIDKKANKKWMEGEKHGSPNVPDGAILTSLDVGDTGTQIPAYWTSKPENHKATHAFVMFHGRLRDGDRYWSVMNHALESAQKDNFDGVPKHAIVVAPQFYSHKLNLGQYNDSTLAWDDVNSWQSGSVAVHPHGTAVSSVDAVDAIVDHFSDSSKYPKMKNLTLVGHGGGGQLMNRYATVGKDASRKGLYIRYIVGDPSSSAYFTHHRPLNDKSIASIDDCPSYNNWRYGFDHFPGTLSSNEHPRAYYKRYINRDVVNIVGYKDVAHNGDQKCMALLQGGHKRRDRNLSWWRYINMIGGTNENLHGFPGDFSDLPDWSDDSNGIIMTRLTVVPDASHDASAVFGGKHGRSALFSRYDVEMGWRPDGWSYHEPKAKYTEHSNWSSSSGSSGSSGSSNMTHSNAHVRKDSNKEQGPNSASDSGSQRSAGDGQFYARSSGSRPLWIMQLMGPMVILLPLLVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9D8</accession>
    <name>A8Q9D8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MGL_3463</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729428.1">
        <property type="nucleotide sequence ID" value="XM_001729376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9D8"/>
    <dbReference type="FunCoup" id="A8Q9D8">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9D8"/>
    <dbReference type="GeneID" id="5853735"/>
    <dbReference type="KEGG" id="mgl:MGL_3463"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3463"/>
    <dbReference type="InParanoid" id="A8Q9D8"/>
    <dbReference type="OMA" id="PTGIWRM"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="72"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="522"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="77"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="466"/>
            <end position="467"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EDP42214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="657" mass="71902" checksum="0B8F4CACEBB65C28" modified="2008-01-15" version="1">MIAGSALMRTVSRTSVPRAHSLRLSVRANAFHASAQASRVVGTQPLRAKAMSNTPGMPDLTKGYPVIEHEYDAIVVGAGGAGLRAAFGLAEGGLNTACITKLFPTRSHTVAAQGGINAALGNMTEDDWRWHMYDTVKGSDWLGDQDAIHYMCREAPNTVLELEHYGLPFSRTKEGKIYQRAFGGQSLHYGKGGQAYRCAAAADRTGHAMLHTLYGQSLRHNTTYFIEYFAQDLIMEDGECVGVMALNLEDGTIHRFRAHRTVLATGGYGKAYFSATSAHTCTGDGLAMVSRAGLPLQDLEFVQFHPTGIYGAGCLITEGSRGEGGYLLNSEGERFMERYAPTAKDLASRDVVSRSMTMEIRDGRGVGPMKDHIYLQLSHLPASVLHERLPGISETASIFAGVDVTKEPIPVLPTVHYTMGGIPTRYTGEVLTQDENGNDKVVPGLYAAGETACVSVHGANRLGANSLLDIVVFGRACASHIRENLEPGKPHKELKGDNGQQAINDLDAIRTADGPRTTADIRLEMQRVMQSDAAVFRTQKTLEEGVEKIDKVVSEFPKVAVKDRGMIWNTDLTETLELRNLLSSAAQTMHSAEARKESRGAHAREDFTERDDENWMRHTLSWFDEESGKVSLKYRNVISDTLDESECKSVPPFKRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9I2</accession>
    <name>A8Q9I2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">26S proteasome regulatory subunit Rpn6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729451.1">
        <property type="nucleotide sequence ID" value="XM_001729399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9I2"/>
    <dbReference type="FunCoup" id="A8Q9I2">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9I2"/>
    <dbReference type="GeneID" id="5853758"/>
    <dbReference type="KEGG" id="mgl:MGL_3486"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3486"/>
    <dbReference type="InParanoid" id="A8Q9I2"/>
    <dbReference type="OMA" id="GHREMEV"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="26S proteasome regulatory subunit Rpn6 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="253" mass="28772" checksum="F2A12ED7336AEFD8" modified="2008-01-15" version="1">MASIAKAKTAKLVRILIDYFNDIPNSREVQIRVTKENAEWARQEKRIFLKQNLETKLIAQYYEARAYREALPLIAQLLKELKTLDDKMILTEVHLLESKVNHAISNFPKAKAALTAGRTAANSIYCPPLMQAQLDMQSGILHAEDKDFHTAASYFYETLEGFDSMDDPRTLPALKYMLLCKIMLTQPEEVHSILEGKVASKYAGHREMEVMKAVADAQSDRSLTKFEKALQQYKDGMCSVIVEIELLTLSKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9K8</accession>
    <name>A8Q9K8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor IIIC putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729464.1">
        <property type="nucleotide sequence ID" value="XM_001729412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9K8"/>
    <dbReference type="STRING" id="425265.A8Q9K8"/>
    <dbReference type="GeneID" id="5853771"/>
    <dbReference type="KEGG" id="mgl:MGL_3499"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3499"/>
    <dbReference type="InParanoid" id="A8Q9K8"/>
    <dbReference type="OrthoDB" id="6021743at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="1">
        <location>
            <begin position="308"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="390" mass="43562" checksum="3E708A2A450B7D17" modified="2008-01-15" version="1">MACNVTGLAWHEGAWRWTTPGGCYAWNGEPNTQASRITEGCDAMTHAAGYDWNHECLFTVLDDARMLNMDQRESPRKIARESLAGGHSPVWGYRRDACGLVAMLIDANECKPWQYHITHKLSYVLTMPNEEPMYVRDRPPVVAWRAWMLWLKQYGAAACAPLWHTLRSRAMHLQEHVVTLAQQRPKSVRVWSDLHKEAQAVSWWMTYAPDEALTQVGSDMAKATWISAWVSGVRRAVAYLESGPSDTGVSVQNGDIQDYVQRLAGALFCMAHDDAHATSHEKSCLAYYSQSLVGQDTYDAWKRAGAPQLGEQCPACKEPIPFDLAPYARCAARHVFDRCIATFALIQGIDTLTCTCCKRQASATALQHISVYAYPSTSSCISCGNRWCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9N0</accession>
    <name>A8Q9N0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729478.1">
        <property type="nucleotide sequence ID" value="XM_001729426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9N0"/>
    <dbReference type="FunCoup" id="A8Q9N0">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9N0"/>
    <dbReference type="ESTHER" id="malgo-a8q9n0">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="GeneID" id="5853785"/>
    <dbReference type="KEGG" id="mgl:MGL_3513"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3513"/>
    <dbReference type="InParanoid" id="A8Q9N0"/>
    <dbReference type="OMA" id="HCIINEP"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="3">
        <location>
            <begin position="49"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="342" mass="38840" checksum="83B3B761BD395B2F" modified="2008-01-15" version="1">MTSEEFKVEIDVPNPGITKEEWYDLRGDGKKQYYLKHWCPTDSTNKLIAPKATIVFVHGFADYCDRYTGVFPVFTDRGYQVSGFDQLGFGRTWHESPDRAKTHGWTTWPDQFHDVACMLKMMRSRLDKQWGTDQVPLFLMGHSMGGGISSGFFTREPTSPPAEDVKRLVSGVLLLSPWLDIHFPIPTSLSIPIVRNVLHWLPRIMLPLVPPANDLSRNPNVVRDVKMNPMSSWYVYVRCLYGPLSGGPKIVTEDYKRWPEWLPLLICHGTGDKVTRWDCSKQLYENLKGLGRSVKLMSFKGLYHEALFEPGQDKVLFGRALVEYVFLLCAGGLVGANVHSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA16</accession>
    <name>A8QA16_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729114.1">
        <property type="nucleotide sequence ID" value="XM_001729062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA16"/>
    <dbReference type="STRING" id="425265.A8QA16"/>
    <dbReference type="GeneID" id="5853420"/>
    <dbReference type="KEGG" id="mgl:MGL_3581"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3581"/>
    <dbReference type="InParanoid" id="A8QA16"/>
    <dbReference type="OMA" id="GANDMHD"/>
    <dbReference type="OrthoDB" id="3365359at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="311" mass="33275" checksum="81883ADFFC4D46D7" modified="2008-01-15" version="1">MYEDRRTALIKLAADGVLDSHAPEESEPQLGSSYAPQGTTQVALTADNLEQIPEAEHLAPGIRLDEPILNEVLCELRIPVPEDASKCNQSIFGLEHEPVEQESVPPELDPRTSEFRPGIPSAGSVFSVAVQPGSPKSVTLESGDRTHDLSGVVTSSQISSRMDSSMGESVSNYRFTTPFRPMSIGTASSSRANSVSVANSEAGSITSDATPFNAEVREQEFAIEQQRMRERAISGGELGIGGPIPPHVSLPQVNISLPQRTFSSSATIGSSPATSVRDGDPEIPSSPTANKFRRVVDSPTPMERQNNNQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA26</accession>
    <name>A8QA26_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cdc23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729121.1">
        <property type="nucleotide sequence ID" value="XM_001729069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA26"/>
    <dbReference type="FunCoup" id="A8QA26">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA26"/>
    <dbReference type="GeneID" id="5853427"/>
    <dbReference type="KEGG" id="mgl:MGL_3588"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3588"/>
    <dbReference type="InParanoid" id="A8QA26"/>
    <dbReference type="OMA" id="IAARWEM"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="467"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="501"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="541" mass="62095" checksum="FFC409162042010E" modified="2008-01-15" version="1">MNHRFATLDGIDDIAPVKARSALRDASHQLIERGLLDAAQWCLELLSCVPHPQGAPLSTPRLGTDEFAHKFPVHSTPALNLESPSWANEEQVGEGATSWMSWENTSPSGQSRGMPSPARSMDPPTSPDEHLHVRISEPSQRNQNSMQYDDVYLLAKTFFDRENFQACIAHLEEQQDLSDKARFLLLYAKLLMYDMHPTKPNELLPPLAYADKSAIDGAHPVLVSLLQDLISPSDPFLLFLKGVILRKLHKRIEAMDCLISSLRAFPYNWSAWKELSRTLNQKNAEREQILDLLPSSFMSVFFLEYSQRQSTQIDLEHFERIDALLMHFPRSAYLLTCRAQALYLHQELEDAADTFQHALELQPYRLDGISEYSNTLYVLDREDTLAQLVQQFAHVSNSAEIWCMRGNFYNQRGEHFRAVESFKQALRLDQECVAAWILLGHEYLEVKNSHAAAEMYRRAIELNPHDYRPWHGLGHVYELNEAWSAAIDYYQQCAMIRPHDARMWASLGVCYDRLGRNAQAIECFKRHLTFRGGNCTDYRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA42</accession>
    <name>A8QA42_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729134.1">
        <property type="nucleotide sequence ID" value="XM_001729082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA42"/>
    <dbReference type="FunCoup" id="A8QA42">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA42"/>
    <dbReference type="GeneID" id="5853440"/>
    <dbReference type="KEGG" id="mgl:MGL_3601"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3601"/>
    <dbReference type="InParanoid" id="A8QA42"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="6">
        <location>
            <begin position="54"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="792" mass="88191" checksum="AFF2199BF8082581" modified="2008-01-15" version="1">MGRDESQAQKLSVTSRDPEVKEDDRPHHTEEMRPSNNKVANELSEEDQQLKTELEMLVERLGEDHTQMHRPALEAMRSIIRTSTSSMTSVPKPLKFLRPHYAQLKSVHEKWTTPTDEKVLLAEILSVLGMTYSNTGEHDTLVFRLLADSMRGANTTAEDLGHWGHEYVRHLSTELGEEYNARMEKDQDTSELLRLALLVVEFSLKHHAEIDAVDLLLELEAVDQLPQFVDKDTFERVCLYLVSCVNLLVPPDDVMFLRTAREIYRKFQRYFEALVISVRLMDPERIREDFESPKNEVMQKQMAFLLARQQIPVEWLQDESNPIKDQALLDCLFNTHLSSHFINFAKELSVYEPKSPEDVYKTHLETARFPVVDSARGNLANIFVNAFVNAGFGNDLLVVGADEGNSYVYKAKDHGKLSAAASAGLSLLWDTEMGLSHIDKFTYSSNEYIKAGALLAYGILHTGVRTEMDAPLALLSEHVESKSSPLQHSAIVGLGLAYAGSCREEIVALLLPYVQDETTSIETAALCVLSLGFVFVGSAHGEIVPSVLQMLMEREPSQLDNSWVQFISLGLALLFLSRQDASDATIETLKAIEHPVSREAQILVDACSYAGTGNVLKIQSLLHDCAEHVTHDSKKEGGSEQTDNESEGARNWYQAFSVLAIALVAMGEDVGAEMTLRHMSHLMHYGDPVIRRTVPLALALLNPSNPVITVLDTLSKYSHDSDLDVALNSIFAMGLVGAGTNNARITQRLRQLANYYAKEPDCLFAVRIAQGLVHMGKGTLGIAPISHRSANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAB5</accession>
    <name>A8QAB5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729207.1">
        <property type="nucleotide sequence ID" value="XM_001729155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAB5"/>
    <dbReference type="GeneID" id="5853513"/>
    <dbReference type="KEGG" id="mgl:MGL_3674"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3674"/>
    <dbReference type="InParanoid" id="A8QAB5"/>
    <dbReference type="OrthoDB" id="3363309at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="497" mass="54559" checksum="A19D2C30DF5DF45D" modified="2008-01-15" version="1">MADLLRESIEAKQPKKGLPAAEHMSYTPSSRIGATFSFVPPPSNPSHFDAQSKMKEPALTTHHDQHTSPNTSPNPNKRICIQRPHPNASCASSTPSTTHADFPSETGSTYSRTTLQSTEVCMEARGGYSRPMSPFQHSFSPKQSMDDSVPTPTMHEPVHQISPPLTARTPKRAICQHEDNENYATSAYESDENDDCANNASQDALELLIDAVYEPEYPNANSNETPVDEQINTSPLSAQRSASSTPPTPTLVRLGQEKCSDTFTPAASTVHPTVSTQESEGIRASYPTQPRSPAAASSEMSVRQRHSACVGSLSASRETEWFTPDLPVGTDLEQQYHESVSDADKRRPYVDRNDGRQMHRQRLSKMSMGKMARRMRSFLESSPATTRESLPNRSDKDPKSSKHNKPQLDPDYYGVADANMLRQALYSSTKMPTSTVPVIATLPKPKDENEPPCSAVRVRSLRTTRKLNVTNGANPAAAATNTSPEKLSAIRSGRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAD0</accession>
    <name>A8QAD0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729222.1">
        <property type="nucleotide sequence ID" value="XM_001729170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAD0"/>
    <dbReference type="STRING" id="425265.A8QAD0"/>
    <dbReference type="GeneID" id="5853528"/>
    <dbReference type="KEGG" id="mgl:MGL_3689"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3689"/>
    <dbReference type="InParanoid" id="A8QAD0"/>
    <dbReference type="OrthoDB" id="266663at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="376"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="493" mass="54775" checksum="C047798A1B2EAD10" modified="2008-01-15" version="1">MNGTKDVAPTCVVARDKLAHDVYQSVLRTRRCDWIELMNCAPMASQYHLSAYSVLKFGLSGAPYAYLPLSLQQPDLTESILSRQQKNEVHSWRLMPHLNARVPIPDSHNAIQMVEKHTDGAHERIALDLEVAMVDKSQDRHMSDTHDTARVVKTSNSHPIRYVSAGVVQLTISSLSPIIPVQLLPNISARVLGHLPPGLRLIHTRDELVDLAHISLTDTVPRSSLGMHLQNSLQDADAYALGQIRGEHLIRMPESVPLEHMLSDNGTPLDSYASSAPKTEAPVLGNLLLSSCPGKKVRLDEPAQGRSPICRDLKIDLDRIKQMGVRAIVCCLDDDELNLLGAPCREYSDEAQSHGLDLIRLPIAEGFAPIHMVRFDMFMSMLILNYTLRGSSILVHCRGGVGRAGLVACIWLLKMNLIAADPEAGPRLCPTADESCYVRSTVLRLIDIVRKRRSVRAIETAEQVRFLMEYVRFVFSQERAHHCLQTCAATHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAD4</accession>
    <name>A8QAD4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3693</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729226.1">
        <property type="nucleotide sequence ID" value="XM_001729174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAD4"/>
    <dbReference type="FunCoup" id="A8QAD4">
        <property type="interactions" value="736"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAD4"/>
    <dbReference type="GeneID" id="5853532"/>
    <dbReference type="KEGG" id="mgl:MGL_3693"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3693"/>
    <dbReference type="InParanoid" id="A8QAD4"/>
    <dbReference type="OMA" id="CIYDNFG"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="318"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="358" mass="40391" checksum="5A1732E1B366ECBB" modified="2008-01-15" version="1">MILTRYEQQKPFYLYTGRGPSSASMHLGHLIPFLFTKWLQDVFDVPLVIQLTDDEKFLFKYDLKIEQVQKFAFENARDIIACGFKLEKTFVFSDLDYVGGAFYHNIVRIARYITTNQSKGTFGFTDTDSVGKMHFVAIQAAPSFSNSFPQIYGTRSDVPCLIPCAIDQDPYFRQTRDVAVRLKYPKPSLIHSKFFPALQGAQTKMSASNESSSIFMHDTPNQIKNKINKHAVSGGQETLEEQRRYGGNPDVDVSFQYLTFFVDNDEEIETLAKDYRAGRLLTGELKKRCIQELQRVVAEFQERKAKVSDDVIRQFMDASRKIDSTPPVPRSASNKPNTAGICSDAGLSTASEASSTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAH9</accession>
    <name>A8QAH9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729271.1">
        <property type="nucleotide sequence ID" value="XM_001729219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAH9"/>
    <dbReference type="GeneID" id="5853577"/>
    <dbReference type="KEGG" id="mgl:MGL_3738"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3738"/>
    <dbReference type="InParanoid" id="A8QAH9"/>
    <dbReference type="OrthoDB" id="2551464at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="168" mass="18991" checksum="CB69C951508747D3" modified="2008-01-15" version="1">MHTIGLREHVRQKEREAGLRCDAPACLPYDSDDEKHRSPLIQLMPCRHEIHLDCLCMGMRIEMAQAQMNCSEIQGDQSSRHAGSKKETGRDLENPDEEEDAADDNEYAWATSSTSLSTGMHSDSSSLDQDTIGKWVTCSACRKDAWARLPRRRQPRRMPRSACTNLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB08</accession>
    <name>A8QB08_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729077.1">
        <property type="nucleotide sequence ID" value="XM_001729025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB08"/>
    <dbReference type="STRING" id="425265.A8QB08"/>
    <dbReference type="GeneID" id="5853384"/>
    <dbReference type="KEGG" id="mgl:MGL_3865"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3865"/>
    <dbReference type="InParanoid" id="A8QB08"/>
    <dbReference type="OMA" id="WTHELIE"/>
    <dbReference type="OrthoDB" id="2386201at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1153" mass="129352" checksum="ED9AE7DADD2FDD6E" modified="2008-01-15" version="1">MQLVSPVQSNAATSSSTSSSRSLSVHISPAGSESPSSGPDTLPAQSTAALEESDSPTTSSEDSTDYERRFRVLKRMMPAHMARACIDDLRAMRHGDVDHPGVSSERPHHVHASSPVSDLQPGQSRRRIRTTHRDSPPIPLLSDVSAESSDEEATEDHSPSPQPRPRESDLRWWTISKQASPPAREGDAIDRMLSRTETRRRRRLRVPSGELGHGRHARNSAIRHRGFSNRTERIHSIPVSAPAWIQSSVEPASHGQSRVAPSASQQKRPDSGIYVVEQKSRFDGVPTRRGDLTSHVRLPYVPHSQAVCNVAQEIHSSPALSTSTAPRPVPRSTYAPAFLSKTPVATASHHSVPLPVSTVYIPTEWQNAPQEWHDELQELLTWDGVRRIQLDYGIVPPTVGLGFAADTDLARGRLHALLRVSSAAAIQSSTSYRGYEQALDVSMGFDEIARAIIPLTDHLEEHHRSTRDLFYFLGSWFSWQAATRSSIHAGVHAIQEDVAAVPAVVTAVSGAAFNAQAACDALCAWAQDLLHLPHSPEVVLWILWFRVDLFWRAMHVECTSVTEVSIMEAAYPLVLRLLSMGISRVVESYISVEHVRDTAAEMWVCVIHVLQAIDAQAFWDVLEAALNEWLGMSPSSLLVDCERIWYTIFAVCALSHFHASTGMAGYKSDLQAHWLGIQRLMMRMKLRFNEQVEQAAPRALLQRRDAYIHLLIHRCFLLHSRWHWSLEHADHLLTHFFDIFNAHRLADLPSEVDHDFAPFLRRFDMGLLYSEPTGTAYHKFLQLLGQASSALQVGPDAQRRLARLFSRMTPVRVMAFSCTQPPTSFEFAMLFNHYSLVMLFLYFEPQSAVQRLRQIRSFLPFARADRSSQIACIRAVVYAGVLFRHHRLDISPIVAWLVDVFHALRSPMSIRDVSEDEPFGARRAKQAARETTRMMAVLLRSVQHLITHATMHSGGVSHAYPPLGLLHPAWTHELIESGELPMEVANEVLNLIRVYLEARARQLQPVLIDTDDDDEFVDDAAWLTDPGLGALLGEETPQPPLDTQLADQLQTHLSPALFHWLSRGTSNSQHVSRPSHWLPHSEAMPLERLIAHAEDDACLTSLVSVWAACAYVLVYHRRRDWSGYLTLGQESWKRLSDSVRKRDVAVQFVLHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBB4</accession>
    <name>A8QBB4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728903.1">
        <property type="nucleotide sequence ID" value="XM_001728851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBB4"/>
    <dbReference type="STRING" id="425265.A8QBB4"/>
    <dbReference type="GeneID" id="5853208"/>
    <dbReference type="KEGG" id="mgl:MGL_3897"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3897"/>
    <dbReference type="InParanoid" id="A8QBB4"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="249" mass="28643" checksum="07EE9CAA2A0DD602" modified="2008-01-15" version="1">MRKIKLKEEEQPELVGIKKKTERREATRETKALRAAKLEKSIERELLERLKRGAYGDAPLNVNEDVWNAVLENAQARVPDAESSALELEEELSDEEAEEDIDAMDAEMRAINEDDDEYGQREFISDDEDESEDDLEDMDSVRGNSQFLTHFSLMIRKAVMMTRMKKMKKMEMQVKKVRRGNLASVHNRSVHLSAALIREANEVSVSYLRAYHQVIHMSKSSMSVKRNRSLLNNSHSGEYEVTGFNVCCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBC3</accession>
    <name>A8QBC3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728905.1">
        <property type="nucleotide sequence ID" value="XM_001728853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBC3"/>
    <dbReference type="STRING" id="425265.A8QBC3"/>
    <dbReference type="GeneID" id="5853211"/>
    <dbReference type="KEGG" id="mgl:MGL_3899"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3899"/>
    <dbReference type="InParanoid" id="A8QBC3"/>
    <dbReference type="OMA" id="ANRRSYY"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="205" mass="22699" checksum="1DF577B4DB634E9C" modified="2008-01-15" version="1">MASSNICKSFIKAIQSRRSIYALSKKPILPDAQVVQLIQQAVREAPSSFNVQSSRVVVLLGNQHDNYWKQIVPTALRQVAGGEAMEASKGKLEAFAAGAGTILFFEDSNLIKGQQEAFPQYASSFPIWSHHSSGMAQIYTWTALETEGYGANLQHYGNLTGETLKKVYNLPESYEIQCEMVFGFPEQPAGSKTFLPDNERVVVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC80</accession>
    <name>A8QC80_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728813.1">
        <property type="nucleotide sequence ID" value="XM_001728761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC80"/>
    <dbReference type="STRING" id="425265.A8QC80"/>
    <dbReference type="GeneID" id="5853119"/>
    <dbReference type="KEGG" id="mgl:MGL_3980"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3980"/>
    <dbReference type="InParanoid" id="A8QC80"/>
    <dbReference type="OMA" id="QCPIPHE"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="356" mass="40254" checksum="1835B57A3BCD66E2" modified="2008-01-15" version="1">MGATQSSDLNVQAQRSRPHNNQAAVAALLLHHHQLALQQTPSTSDRPAKCPVPHGPRGAMARSLASDHEAQLNPLNKMPTLSQKRAPEQKMELSRERTVSSIPRAKSSAAPGDSPYGAPQCPIPHDQRTRHEKEASCPVTHDKKSLDDGGINNDSETPGFWEYPSPQQFYNALVRKGWETPEEHVEMMVLIHNFLNERAWKEIIDWETLAGSDVSQLQLARFQGRPGTLSPRARMFMWLAWAFPNKFSSEPPFDRHDWIVRRGPTEAHPEGEEIRYIIDYYSNEDEDAHSDENEASFNLDVRPAISNLSTIQMRWKKLLQEYESGELFEPFRSDSSSAQPRTSVPVPEQHRSASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQY2</accession>
    <name>A8PQY2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732763.1">
        <property type="nucleotide sequence ID" value="XM_001732711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQY2"/>
    <dbReference type="FunCoup" id="A8PQY2">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQY2"/>
    <dbReference type="GeneID" id="5857069"/>
    <dbReference type="KEGG" id="mgl:MGL_0538"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0538"/>
    <dbReference type="InParanoid" id="A8PQY2"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="228"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="502" mass="55580" checksum="37B44BF452F7D828" modified="2008-01-15" version="1">MSNMLIAPSLEVVREALTKEGHAQIGRIIPVYTKIPADLLTPVMAYLRLSDGAKVGQESFLLESVNTGERLGRYSFLGVKPRDVLRTGPGLDCEGDPLAHLEKRMRSYEYVAVPELDMFTGGAVGYIAFDCIQHFEPKTKRELRDPLGIPECVMLLCDSVVIFDHVFQTVYCVSHVHVTEDAADIDALYTACSNKVESLVRTILQDTTPLPEQGKIGPHGQPVSNVGKAGYEHFVTELRKHILQGEIFQAVPSQRLACPTQLHPFNCYRHLRRINPSPYMFYVDCGDAQLVGASPETLCQVVRGKVAVHAIAGTVRRGHSPQEDLKLGHQLLHSEKDRAEHIMLVDLARNDVSRVCDPTTTRVESLMNIEKFSHVIHLTSRVTGQLRPSCSKFDALRSIFPAGTVSGAPKIRAIELVSELEQERRGVYAGAVGRIDFAKDDLDVCIAIRTMTFKNGVAYLQAGGGIVYDSVEEEEYVETVNKLGGNLRCLAQAEEAYRETHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQY7</accession>
    <name>A8PQY7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732768.1">
        <property type="nucleotide sequence ID" value="XM_001732716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQY7"/>
    <dbReference type="GeneID" id="5857074"/>
    <dbReference type="KEGG" id="mgl:MGL_0543"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0543"/>
    <dbReference type="InParanoid" id="A8PQY7"/>
    <dbReference type="OMA" id="PGDWIPW"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725328" description="T-cell immunomodulatory protein TIP C2 domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="9">
        <location>
            <begin position="519"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="668" mass="73755" checksum="9071F8DA781E3760" modified="2008-01-15" version="1">MRLGADVLLAAVLVCAVHAWSLFPRKRFKEEGFLRAGSLGLEDVRGQVAAWGYFRDDRFLDAWIVDASRQSMTVHEWNHANFSFHSTPSAHISVPSDMRIANAILADFTYDGRTDVLVMASSTSRASPPLSMFLWPMLPDGQLGEPISLPASMDAQPMSVDAAGSLRGDLLGHAHSSPDTLSVWRNVDGQMRLETPVMNGHIPPCRLAHPHSSANVDMNGDCLADLFLVCQGARAGQLTYQIWTARADTPMAYDLARTGDLPPGAGALSFADMNRDGTMDVVFPSCDRSQCYINIAYNEQMPLCSQERRGTLFSSGNPMAPERCRDALRLCEPDASFVLDMSTDATNSRFARLPVQDLTGDTRILLTDDVGTYPQPVPVRIGDFNMDGYPDLAILTVPRGALHGQTRVHLLESVRCKKHGSVGCTASKPEHRTFRRVPNTVLDQEAYVRSVSFVDLDEDGTLDFVLQSLPPATTRTSDARVLSFVQNNYFHDAFFLKTLTLNAACGARCEREHERAYSPWGGSLLGASYKFAVLDPNGVRRAQQVAQQPQTGYSALTPPYAFFGLGRTNNYVESLFVGSTLRQADSFLVLEGVIPNSEVIVIPTDESPDAWRRELFLHPADWIPFVTMALAGLIALLSLVVFMLDLNEKHEDERERRRAVHAINFDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRD3</accession>
    <name>A8PRD3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0026</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732251.1">
        <property type="nucleotide sequence ID" value="XM_001732199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRD3"/>
    <dbReference type="FunCoup" id="A8PRD3">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRD3"/>
    <dbReference type="GeneID" id="5856557"/>
    <dbReference type="KEGG" id="mgl:MGL_0026"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0026"/>
    <dbReference type="InParanoid" id="A8PRD3"/>
    <dbReference type="OMA" id="QARIVHC"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="881"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="232"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="329"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="448"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="603"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1120"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1191"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="687"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="752"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="910"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1219" mass="134482" checksum="B544AE7FFB778280" modified="2008-01-15" version="1">MSHDASTMGGNMGSAHGSGNLNTSYLQTPPRNYLRQQQPTLLTPTMHPQRSPQVNQPITMTSSPWSTSPRQSDASLSPKGLYDRRDQVGLGELTTPRWMMSHGHPDADFPQRLLPLDSPAYTGSVFANTSGGTGDLSTPGVAATRDRNSAREKSARAISYSLSNTNHASSSKLMPSFSSMQFDEAPVDFPSPPIEPYEVSSYETPARRADRRWKPSTACTASVANGVDGAGTSAATGSSASAVPAGAAGTPPAPPPASMPVQMENSLHSPPVHGSLTDITDNMYHMNMSPLSTPQTQSSSLDVFLDNPAQSPFQSQSHTQVQPPYLKVHPQTHSSQASFVASSVPSSSIPSQERAGFSRVEEQAGPDHSRWSVAPARAPPSPSVLPSGMTFSEAAVPTSETSSPRVPKSPRWRQRAVSRVDDTDESSSLAGRLSRRSLVALSSFFKSSPRRTTKDVSDANAGSAGGSTGNGTTAMPSAVAYSSAKVATPEPSTPPSRSRLSFSRRRRQSLQHVRNSLARQARADQPGVPDVPHVRDTPNTRASTGANLSTPTKYAPNLPPKSSRREGADVVVPLRTEPSPYYTAKAQGSRIPRASSMMRILRRKSGDQDDLRESRLPVSSSMQSISSASESPFVSLRSNNNQNNAGQRSEQRPLRTSSRKAVEASPVKARTLRKSQASAEAAEALRRQQTAQTNSDVGMSTTSLSIPATSTNANATSVQETARSHASRTPSMASSMLESGIPVPTDVRRRPPSAQSRRSIRVSVDDSQAGDDEMERHIQRVFRRKLAGGARYEDLEKQLAFPQPTAATKRLSPRQAEVIYGNHMCPYELQEIHQYDSIYYVGSYARHKHYAVPEKTDRNYGYDDERGDYIVNLRDHLAYRYEILKSLGRGSFGQVLQCRDHKTGQYVAIKLIRNKRRFHHQAVVEVRIMEHLTRADPDGQHHVVHMTDSFTFRHHLCVTMELLSINLYELIKANSFEGFSATLIRRFTLQTLQCLALMRQARIVHCDLKPENILLVHPRRSEIRVIDFGSSCYEDEKVYTYIQSRFYRSPEVILGMEYNMAIDMWSLGCILVELFTGYPIFPGENEHDQLACIMEVLGLPDRHLLEKSTRTKLFFDSTGAPRPVVTSRGQKRRPQSKPLASVLRTNDEWFLDFVARCLTWDPERRIKADAALHHPWFVHRADSVIPRLPQTRRLTRPDTARSLESGSLLPRATPASHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRR7</accession>
    <name>A8PRR7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0112</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732337.1">
        <property type="nucleotide sequence ID" value="XM_001732285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRR7"/>
    <dbReference type="FunCoup" id="A8PRR7">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRR7"/>
    <dbReference type="GeneID" id="5856643"/>
    <dbReference type="KEGG" id="mgl:MGL_0112"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0112"/>
    <dbReference type="InParanoid" id="A8PRR7"/>
    <dbReference type="OMA" id="EQNEAKY"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000087">
        <property type="entry name" value="DNA methyltransferase 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="196"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="517"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="562" mass="62382" checksum="69AF28A414B550CB" modified="2008-01-15" version="1">MSSSDVRDILSLPNRATTAESGQHRAPARAPPTLPGDTRQKQRPEGMSRELYALLGPNAPSLVMSSATGGPDGLASSGGTQPTFQPKFQRKANSGVVRRWAWTPFRNPAREDTPTDTDSAASEALLGQGLPTRRGLVLHHWKPVLSSTSSLSKQSGADDDDKEMGDEVALDEAWAPFNTSSQVFHYTTEEYTQYLTDSDWTRDETDYLIDMCEMYDLRFIVIADRYEWPGSHRTIEDLKARYYTICRRLLRERISNENVETRHTQLQTFAYDRQQEMERKNAVQKLFSRTPEQLAEEEALYVEARRLEQNETKFARERADLLRLLGGFDGVPSYSAATVAAVGAGLVWPGSSHHVDQPFDDKKHKRRRTDVPSPPAKSKSDAKQQLFDAQHFITRFSTTGPHVLRTPYPNLIGTPSALPPVASATSGSSTKSENAAHHGAYLRSTRMLTFRPNQYTRVMQALSELHPPVGARLVFPTATNVEKWETLLGAVAGGLEIKKQLDRVEAEYQIARARLAAAEQAAAKAPPPRTESGTSDTKVHGSETESQDSTSRSSGAQKSQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRT8</accession>
    <name>A8PRT8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0126</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732351.1">
        <property type="nucleotide sequence ID" value="XM_001732299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRT8"/>
    <dbReference type="FunCoup" id="A8PRT8">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRT8"/>
    <dbReference type="GeneID" id="5856657"/>
    <dbReference type="KEGG" id="mgl:MGL_0126"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0126"/>
    <dbReference type="InParanoid" id="A8PRT8"/>
    <dbReference type="OMA" id="CCMQALY"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="290" mass="32163" checksum="0EF45DF1A777718E" modified="2008-01-15" version="1">MRQKRAKAYRRLLHHYVLHYHFREPYQVLIDPTFAEALVRFQVHEPLKQLGSVLHGKVKPMITQCCIAALYDAENHARNELQNSDEQQTYKQAIALAKTWERRKCNHKGTQTAGACLASVIGEKNQHRYMLAADDVQVRRSLRRSVPGLPIVHYSQSVLVLEPMSDVTEQHIRHMEQSKSALSIEEQRILQTPAFSPASTNANAPSQPAAPKRKRAKGPNPLSVKKSKSAGKSAGKAGGLPEGSAPSKSHATPAGRSGTSSQSYVSSISQPTSQRRRNKKRGRGSHSTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRV9</accession>
    <name>A8PRV9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732364.1">
        <property type="nucleotide sequence ID" value="XM_001732312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRV9"/>
    <dbReference type="GeneID" id="5856670"/>
    <dbReference type="KEGG" id="mgl:MGL_0139"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0139"/>
    <dbReference type="InParanoid" id="A8PRV9"/>
    <dbReference type="OMA" id="CPVESEV"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="465" mass="49875" checksum="ED0C87FBACDF87BE" modified="2008-01-15" version="1">MEEDVEVPGSLTPQIHAVRQYPSFSCSLRDFRLPTASMETDVPRTPETRTAVRRPAVRRMPPVLRDKNKMRVAELLSEEQCPCAFEVASEARLQRYLMGQTSPQDHVSRRARRSRMAMESGSTAAAAAAASATTAATTTAMSESIPSLAAAATQSRDARMASAFGTITHHISPMRPDTDMLCDMDNSLSAPAPVPCMFSTASNIGTQDMYEDDDKDFDDDDDDDDDDDDDDDDNDDDDDDNGGGGGGGATTATNQEGITSAVGHFALESHPRPAVDGMFPQPIASDMAVPEDSMFPPSSVPDSPWPVVPSSPRITGIKRKHEEDPGSTYARRPAPLPPWLLMSNANSPRRPIWTAPGGTVSPSSSPLAFGMGHSQRRTPTPLPSMPPLFSFPPLSRDEPMTRPSSPTLSAWKPLARSPGTGSGPGYGSGAIGLRLGSRVAWDASHLQDHTEGHDMDEGVRMMGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS50</accession>
    <name>A8PS50_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732419.1">
        <property type="nucleotide sequence ID" value="XM_001732367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS50"/>
    <dbReference type="GeneID" id="5856725"/>
    <dbReference type="KEGG" id="mgl:MGL_0194"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0194"/>
    <dbReference type="InParanoid" id="A8PS50"/>
    <dbReference type="OMA" id="PRTYFLE"/>
    <dbReference type="OrthoDB" id="3350668at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="307" mass="33298" checksum="F22B1FBC0F4D3BC7" modified="2008-01-15" version="1">MDLATRIATAYDAACVRAATPGVAESDTSTAGGFIVDVNDETAGGFVRETSCFSNSNASPVLPVSALPYALDTLELEGAKRRDVQELLEAHSGYDEMHAEPVVPRTYFLEAVEAVMGGIRRSKRRRLVRRQNGEEASSNSDGGTASQDEYAPPDKEPAFSSDEDDTGARDENDRAASSMSSAQVSKHDKNTNISKAKKEQGRLLYRLLLERIPLVAPTMLANYPSIGIREDVTDEEIESRQIGIDELRYATRSLGESRSTSELADMLYEAQALASNSTQTRSRAPAEAPRIGLNEFTFITGRAGVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS64</accession>
    <name>A8PS64_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heat shock protein Hsp88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732426.1">
        <property type="nucleotide sequence ID" value="XM_001732374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS64"/>
    <dbReference type="FunCoup" id="A8PS64">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS64"/>
    <dbReference type="Allergome" id="7672">
        <property type="allergen name" value="Mala g 10"/>
    </dbReference>
    <dbReference type="GeneID" id="5856732"/>
    <dbReference type="KEGG" id="mgl:MGL_0201"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0201"/>
    <dbReference type="InParanoid" id="A8PS64"/>
    <dbReference type="OMA" id="WEQSPEI"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="742"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="87471" checksum="D11CA625DCA9D19E" modified="2008-01-15" version="1">MSSVVGLDIGNISSKIGVARARGVDIVTNEVSNRSTPSLVSFGQKARALGEGAANAQTSNFKNTVGSLKRLIGRTFQDESIQQFEKPFVNAELVDAKGEVGVKVRFQGEEHIFSATQLLGMYLGKLRDTTQRELGGSGVSDVVLSVPIWFTDAQRRAMLNAAEIANLNPLRVMNEPTAAALGYGITKTDLPEPENPRNVIFVDIGHSSYQVSVVAFCKGQLTVLGAWADPNFGGRNFDRALMEHFAKEFNDKYKIDVLSNPKSTFRLAAGCERLKKVLSANTFAQLNVESLMSDIDAASQLKREEFENLIAPYLERVHEPLDAALSQSGLTKDEIFSIELVGGSSRVPALKERISQWFGRPLSYTLNQDEANVRGCTLACATLSPVFRVREFSVHDISSYPIKVSWEPAPDVPDEENELVVFNTNNPVPSTKILTFYRKEPFTLDAAYCNPETLPKGTNPWLGRVTVKNVAPNAQGEHSIVKVKARLNLHGVLNVESAYTVDEIEKEEEVPVVDPAAPEGTEPKTEKRMVKKLQRKDDLPIVSGIGLLDQSMIADLKEQEGKMYAADKLVADTEDRKNALEEFVYDTRSKLDERYSQFVQPQEKEQLFSMLGESEDWLYTEEGEDASKSAYVSRLETLQKAAAPVHFRWKEHDERPRAAAQLREVVNKYMSVFENEPEKYDHLSDDDKMKVIEKAATVGKWLDDYMYKQSELPKNVEPKLTSDEILRKKDDVIYVCTPILTKPKPRVPVDTPKPEGNREGAPQSEQQQQQSNENQKQGEMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSI8</accession>
    <name>A8PSI8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein NUP160 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732490.1">
        <property type="nucleotide sequence ID" value="XM_001732438.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSI8"/>
    <dbReference type="GeneID" id="5856796"/>
    <dbReference type="KEGG" id="mgl:MGL_0265"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0265"/>
    <dbReference type="InParanoid" id="A8PSI8"/>
    <dbReference type="OMA" id="ASMYQHA"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056535">
        <property type="entry name" value="TPR_NUP160_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23354">
        <property type="entry name" value="TPR_NUP160_120_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="80"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 middle TPR" evidence="6">
        <location>
            <begin position="904"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="5">
        <location>
            <begin position="1138"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1407" mass="153856" checksum="EE10817C87BF859F" modified="2008-01-15" version="1">MLPQGIASVPLDVLHPRTLTPHARSSYTVPSSRRAAWRDVSSTSPSLGGDAAAPHTVASHASHAATCHVSVLGAHVMALARVLVSTRELEVQIVGPQLHAPPMSFIFPAPILAHVGIVEDAASSDIHVLAITQTGFLYRLRLPLASFLRGQPLPHAWAHEHQILHLSSHASASSTSSASASTSQPSRSPSTSTSLADTAVATSVHVIDIALILVSCADGALLRINSELDDRGAFTGAWLESVLRPSTFLFSRLFSRSHSEHVAPTQTLALATHIRDTDTPLAFSVCRDRKLRVWNIATDTLVRTLDLPGSSDTVWEERTTQPLVQLFYPADRSFSFYVLVYVPMQAAACLAAYGVELEESSSWSGGVGDMALVWSRACDARTNAPDIELRDMAVVYTGQVWRVWLLWHAAGAPLLQTTLVDGLRAPAVNQAPLVLGDTDDPWATVHPLSPYTPLHGPDMDAALESQASAVATVFVSRLCEPARFSATTLAAALEAEGVHVMGEPLPRIVAAIAATVGAGSLEAWLRFTRRVELIDRAARWPLRLCMLDDVPCIIARHALGIACARDAGAWLASLAARLAAAAPHPDRPSARLAGEAASAEYAYVVNSLAQLPHSDGTHDLKDYARIHDGSTHLLRVATLAAELYDSLGPRAPRLVDAYIAEAQRTTSPMRVRIPTSLHGRLSALIEQMGGDGLVREAERLVTLYQHDSWPSFAWLDALTAYAHMAGVHARLHGTRALLVLLSLVTHTHVPQIQRIRSIATDVWHTARAMYVLASSIDDEPTVGLVHRALQRGVPQGASVDAFCNAVLTDAPDVVRTCLLTAASSCSSSTGSNDSVLVHDTACTPSTTYLIAKADACRGRVHEAYQGFVCVNAALTAAAKTHPVWERVLPADVLEASDHPTTQFRFWCHAATLVEGDVRTSYECYRHAMHALEAGAKDVLESDARKVWTLVFRSQLALHMYEAAGATILSLPFDDLRTTCITSLVTTLCEAQETRTLLRLDLLEWQPHIERTLSFQARHASPLAHPSYFHILYAYHVSRGDYKSAAASMYQHAHRLGVLTRDAPSLESMQAYAVQQAQSFLVCINALVLLPATLAWFAHDNTDSLAATGCPTDRHALRGRVTHYVPQPAGPASLAIVQLADVRREYHELLTRLQLMQTYPELAHGATPWRADDALPLFVANDDYDAAWSTAEQLQLPMDSFFDALTLKCVLLERAFHKRAAHYEHEDEALKSLYMGDEEEADPNAAFLRRSARTASWPGHAHERAWKYLRVHLEATEHGVQYRRIIAERLIALRAWDLSPEWLIDWFRQHAPDVLIRVWMQYGMLEHALAYCIQLVDASLSELRTSNAQPKACLPYTLMDSLLVAADKRGLHEPSTTLRKSLDARMNALKKKHPIPHAPSSTAIATSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSP9</accession>
    <name>A8PSP9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732521.1">
        <property type="nucleotide sequence ID" value="XM_001732469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSP9"/>
    <dbReference type="FunCoup" id="A8PSP9">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSP9"/>
    <dbReference type="GeneID" id="5856827"/>
    <dbReference type="KEGG" id="mgl:MGL_0296"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0296"/>
    <dbReference type="InParanoid" id="A8PSP9"/>
    <dbReference type="OMA" id="KPLIWCD"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="169"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="439" mass="50397" checksum="D8C17B266098BD78" modified="2008-01-15" version="1">MASVVAILDLKGKPLIQRSYRDDVDPAALERFLPLLTEIEEERGAGAIQPCLSSQGVNYMHVRHSNLYLLALSRRNTNAAEILLFLHKLASVLEEYFKQLEEESIRDNFVILYELLDEMMDFGYPQTTESKILQEYITQESYKLEVQVRPPMAVTNAVSWRSEGIRYRKNEVFLDVVESVNLLVNANGHVVRSEIVGTIKMKCYLSGMPELRLGLNDKVMFESMGRSTRGKSIEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQIKPLIWAEAVVERHEGSRIEFMVKVKAQFKRRSTANNVEILINVPDDADSPKFRAAIGSVSYAPELSAMVWKIKQLSGGKEYLMRAHFGLPSVQDEESIVRRTPINVKFEIPYFTVSGIQVRYLKIVEKSGYQALPWVRYITQNGEYDLRTQSEKNSANLAHFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSQ3</accession>
    <name>A8PSQ3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732523.1">
        <property type="nucleotide sequence ID" value="XM_001732471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSQ3"/>
    <dbReference type="STRING" id="425265.A8PSQ3"/>
    <dbReference type="GeneID" id="5856829"/>
    <dbReference type="KEGG" id="mgl:MGL_0298"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0298"/>
    <dbReference type="InParanoid" id="A8PSQ3"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="690" mass="73025" checksum="952D2BF231127AE0" modified="2008-01-15" version="1">MQQALARMQMGHGINLASLTPQQHQQLLVTAAFRQGIPMDEIKNMTPSSRLALLHSVTQGMPLPNTPTNRSADPQLHARLLLQQQQQQQNMLFMQQMQSQAAGQVKMPQSGNATLQALLQRQPQRMPPGTPLAGSKAPVNGAEMGTGGNMGVMDASMAGATAAAHAAMASRPMLPFSRGDTQSPSMQPHGSASFAGGASGGGMQTPEQFTLQQRQMLMIQYQTLQAAIKNEWMKAQSATVPGMAQLSLATAQQLQAKAQSILSFLHTDPSQPASFAGDPSMQVQMFQHLQQQQQQQQQQQQQQQQQNALPQQQQQQQPQAQLPQPPQQQQQQQQQQQQQQQQVQQPPAPSQTSQLHSQPMLASTQLPGGQAAMNTALLGQTQMAQKMGPVLPGQNLPAGARMHELDFSSVPSVNGSNMTPYFPPSMGMNGMAPSLSTSQHPTPTQPQTQAMMNGFMSPGMPNANGTAPSTPLTSHATPQAAASNTKGRMNTARASVGPSQGRAVTDMPMSPWQTHPPTPHAHESPSAPMPKKERTRKHARSSSTKTPSASHASTHGAGAAADRSEDVPPKDEPQDWDSSTKSDGALAPAPPSKSLVSGSTSSTSGAQPMLSMPSMMDDMVTGSLSSASGTGNNADDFSVMFGVSDIFDFDGGDTTSNSGGGFLGNSTFSGEGDGGDKTETKTSESNSDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT00</accession>
    <name>A8PT00_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732569.1">
        <property type="nucleotide sequence ID" value="XM_001732517.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PT00">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT00"/>
    <dbReference type="GeneID" id="5856875"/>
    <dbReference type="KEGG" id="mgl:MGL_0344"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0344"/>
    <dbReference type="InParanoid" id="A8PT00"/>
    <dbReference type="OMA" id="LFRVCNM"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="660"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="913"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="576"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1466" mass="162460" checksum="1A72B1654B37456F" modified="2008-01-15" version="1">MAPRKKNAAIKSSGAMSSKAAPLPDWVKGGGAKPPPPTGTNRDGTAQLFPPRYKTPLNIMYERIQKMPGWLKPEVEPLHRKDGYTCAITLRKENKQEKSNPFTIRMEPKEPGARLRCETSLHAKHWGATYVLFRLFNNLGLHRVLPPGPREYWMQLEEVKAQSPDHDSWKWAADPFDAIAKRDAEREVREKERAAREAARNDPTKKPLSKAWQRAMEVRMAPELRDFVEATIRARMTDVPAVEVDGLDSSMQGMSIDVDARELEHELASLGVRPGYIRRIVSWLQDARAKYATPAAWQQLRLSHPLLASILALPNKEAAVEYLVLYTPEQDLPVKLRPTATSESFIKSAASGGGQDALVDRWTIDKFSKSAGFPRENVAQAIEAVRESDQQLSNTAREGVVLDLLLRKLLGQHAPVSSLVTCDPRPDDDLTQKRHDERVMLAACLGDDMLQPVPEQDAITSDDYDICLGTFEKDKVFLRVSPSHPASRYLANSEAWPSVYVTSPTLPSFLRLALTRHALQCLQGQRSDIKEALDLCEGGVLFLLCEELRECIPAYVRDPPPLDEVMESLVEAAPNAAARAIQETEATRRHKQQQKSTISSQSHSLSPQRTRKARKLERNGHVDTAMHEAHTKWHSSLKYVESVGPIRESLPAYASQDMLLKTLREQRVVLIAGETGCGKTTQVPQFILDDAIQRGCGSLCSIVVTQPRRVSAMGVAARVATERGESLDTSDIPDEAQVGYAIRGERRASKSCRLLFTTTGVLLRRLATGTDPNLESVSHVIVDEVHERSTDSDFLLLLLREVLARNPSLHIVLMSATIQAETFTSYFDGAPYLFIPGRTFPVQEHYLEDIVRLTSYRVPVPFTREDERLNKLVDGSMLSDADISTVRALCASNHTDYDLLAHTVAYAMKRAEKVDFTGSLTGRAAILVFCPGVGEIRQAMDAISALCTDGVVLLPLHANLAPSEQRKVFQAVHKTERKVIVATNVAETSITIPEVCYVVDTGRVREAQYDAQAGVSRLLDAWASRAACKQRAGRAGRTMSGECFRLYTKGMEEHLQRPQSIPEMQRTPLEGVVLQVKAIQPTGDVKAFLQKALDPPPLDALEATHKRLIIAGALHAEGGYAAKLTPLGRHLAQLPLEVRQAKLLVLSCLFGCVEPMLHVVSLLSCRSIVASSSQRDETKAKARSAFLYGQSDLLSYANLFATWLAMRHERRPMKEVRTFCDAHGLSMQALQDVDMTRITLLRQLEELGLIGRDYVISYRSQGPAWPSKISMLPLDTNSGNINLLRALLLASLWPSIARVDQPTAKYNASTSGAVLKEAQAKELHYYDESDGRVFLHPSSMLFHATKYKTNYVVTFAKSASGAAGQARTYLRDATEVPLYALLLLGGPLYVDHEVGGITISTGIEASKDAWVRLRASTRIGVLCRQLRQLLDRVLEEGVLDVQALSAAHNQHVVQAMIALLAQDGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT16</accession>
    <name>A8PT16_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732577.1">
        <property type="nucleotide sequence ID" value="XM_001732525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT16"/>
    <dbReference type="STRING" id="425265.A8PT16"/>
    <dbReference type="GeneID" id="5856883"/>
    <dbReference type="KEGG" id="mgl:MGL_0352"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0352"/>
    <dbReference type="InParanoid" id="A8PT16"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="160" mass="18435" checksum="7C099994E5FBE8FC" modified="2008-01-15" version="1">MRFVSGTKLDERVIRCDLDPGYRDGRQYGRGRSGGQVRDEYRQEYDAGRGGWGHNRLREEEEKKRQEDAQQRERERHERREEVYQEAQGTADAHKAPVGADAEYYETEHAERAGHATDEMTRDSGATKRQRDDDPDEQAGETGERHLDAGDAKNPRIESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT51</accession>
    <name>A8PT51_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732593.1">
        <property type="nucleotide sequence ID" value="XM_001732541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT51"/>
    <dbReference type="GeneID" id="5856899"/>
    <dbReference type="KEGG" id="mgl:MGL_0368"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0368"/>
    <dbReference type="InParanoid" id="A8PT51"/>
    <dbReference type="OMA" id="FIFRSGC"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="232"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="491" mass="54327" checksum="26EE1C20C2D8549B" modified="2008-01-15" version="1">MLARHGHRGITTKHAVRTFVAASAVRHARGPSSAMPSSSRKPSSSSPARGDKPRKSVLRHFLESGGILHQNDAPKFDFVSLKSSMPSSHTFRRTRLPMSKAKALAQESRALREQVASSASATQGNVSLASSAAMLADASPSASDGLSKTQTSAPWTEAEPRPTLPLTSTHITSSELPEVAAFATAKSYNFDVLLSSGRLPANWIWLEDREVIYIPSWPPTPAKASTTQRGSVFIFRSGCYVTWGMSTEQNSAFYRDVIRDGSVPPVEESRYDVAGDEAMEYVHIPNEVTRVVGDLIVIGHQRDEKERHARSSRAPSTPSLTLQARLAFSQGLAASARLSVQESVLLDYLESVAPIPSRLESSGKVPLPRKEVIRKLGTLLRIRQRLNLDRDNFIDDPELYWENSHMEALYRSICSALDMKPRFEALNAKLNHCENLLEVLRALLTEQSSHHMELIIIYLIAFEVGMALVSHEYVPTPQTFWQWLWSSATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTV2</accession>
    <name>A8PTV2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0483</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732708.1">
        <property type="nucleotide sequence ID" value="XM_001732656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTV2"/>
    <dbReference type="FunCoup" id="A8PTV2">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTV2"/>
    <dbReference type="GeneID" id="5857014"/>
    <dbReference type="KEGG" id="mgl:MGL_0483"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0483"/>
    <dbReference type="InParanoid" id="A8PTV2"/>
    <dbReference type="OMA" id="VPPINCI"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000013">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="87" mass="10182" checksum="8286A07D7B76990B" modified="2008-01-15" version="1">MSGRQQRVMIQPINVIFRHLQQQTRVSLWLYDNVEYRLEGKIIGFDEFMNVTLADAEEVHMNAQKDRKPLGRLLLKGDNITLIQPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU24</accession>
    <name>A8PU24_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732745.1">
        <property type="nucleotide sequence ID" value="XM_001732693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU24"/>
    <dbReference type="FunCoup" id="A8PU24">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PU24"/>
    <dbReference type="GeneID" id="5857051"/>
    <dbReference type="KEGG" id="mgl:MGL_0520"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0520"/>
    <dbReference type="InParanoid" id="A8PU24"/>
    <dbReference type="OMA" id="CGYFNPS"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="260"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="416" mass="48324" checksum="F27939E4C0593D36" modified="2008-01-15" version="1">MAGSMWPWWPKAWNPFTRWSWSNTFDYETILDALEKEIRTTESTLVDIRARKRRAIHNVLQIMITLWIVSLIVLWICSSFFWGREWAASRSLVVVVLLLGTPLFIAVLHRLVSIWFRRLERAQETHLNTLRKQKREKINEIKKATDFDHLNNLLERYDEEKQRPQLNPPSIQPRFETSSKPLRRSSTLSLRRHASSDTLQNSSKGSNPSDEQRTGQLELLKSLAPPISGLPVLGVPSAQGNTESRPYRTPSPQPPYPRGWMDKLADMILGTDPYGATPEDQQYALICRHCFRHNGLVPKNELHEIRMYDRIHSTFTHTSTEYICPSCHKLNSRRPSSRPVSSPFVRERRQFTPADDKRASLPAQSMSASRLTDYLHWPSQDSLRRSSHLRTHSKDERPKVPREGQSDTDDMQLDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUB5</accession>
    <name>A8PUB5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732051.1">
        <property type="nucleotide sequence ID" value="XM_001731999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUB5"/>
    <dbReference type="FunCoup" id="A8PUB5">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUB5"/>
    <dbReference type="GeneID" id="5856376"/>
    <dbReference type="KEGG" id="mgl:MGL_0644"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0644"/>
    <dbReference type="InParanoid" id="A8PUB5"/>
    <dbReference type="OMA" id="KQDRTTY"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="483" mass="54441" checksum="297665814A074412" modified="2008-01-15" version="1">MLTKVTKLNAIREERRISDAAQDATKDSDAPEISGGMGNSDYTTTKNTRVDTMLVDVFYLLSLFFLTVGRSRECPAMFSQIGCMKQLLDHMDESAVYTEADLTPFISRIQELRDIIKNDERQNKHPPQLTKLMAHKLEACQQVVNRLQNSLSVISVELLAIHQKLVQIRRQLNAAAARPKPPKGDVKQLQEELRKIDAKRVDGKFLGPGGSSVPEGQEMLAGLLESCFELSNDILVRNSTVSPTLQPIYDRLLETKQQLEHLEQRHRWSLRETDLWTYHLTLKDIDRMRVNGKFLDSEGRQPEGQLVLLYLLRRSYGLINKLLSSSEPLSEELIPVSDKLSTISKCLREVSKYGGTFSLRDMYPYRLALHQIDSMRKPVPDKDGHPTDVARWLAPDGTVPEGQSIIQAQYEEVEQTIEELLNREEEDEEDNETLDGSGVSETLECDTLSDSDRVMSSSQVVESHSGNSVASPSGELDTKRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUI3</accession>
    <name>A8PUI3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732100.1">
        <property type="nucleotide sequence ID" value="XM_001732048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUI3"/>
    <dbReference type="STRING" id="425265.A8PUI3"/>
    <dbReference type="GeneID" id="5856406"/>
    <dbReference type="KEGG" id="mgl:MGL_0693"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0693"/>
    <dbReference type="InParanoid" id="A8PUI3"/>
    <dbReference type="OMA" id="IRHTIAC"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="7">
        <location>
            <begin position="37"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="258" mass="29130" checksum="A975B496DA148597" modified="2008-01-15" version="1">MSVSTTHATGTNIGLAASVDTTMTSASKSAANQGHGADMVIKFEGMPQAYAEGRKRAPMELLEERAHELERLMERLREVGLSCISRAGPRVRGQVLIFVRCPEHLLRQMRHSERVHDFLHGVVTSSRLNQDEAFKPAQRVRYTQIRIAAPYKDSPQKHRGAGVSPKCAEFPHVMDMLPLHDKEFNRAWISSWSKMSLSSFFYGIGQHEFDKLRDQFGVDIAMYFSFLNTYFLALAPISVLGLIFWAAIRHTIACMRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUQ7</accession>
    <name>A8PUQ7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732154.1">
        <property type="nucleotide sequence ID" value="XM_001732102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUQ7"/>
    <dbReference type="GeneID" id="5856460"/>
    <dbReference type="KEGG" id="mgl:MGL_0747"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0747"/>
    <dbReference type="InParanoid" id="A8PUQ7"/>
    <dbReference type="OMA" id="DRQGITW"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="309" mass="35190" checksum="255DC1D6F85D73E2" modified="2008-01-15" version="1">MKNMDVLFHTSMAPKLRISAGPTANKLELVAVNHDDKPVVIDSDCFQGKLTVRVKNFHGELPENVEYLEDVKYFSMPYGSQMSYSIQMQGRFPAGVNANDLVFGNEFDEPIRDSLPYGMGLVLRFASFIDPNLKHDLYGDKPWALSPFLSTVFRAKADRAVEGTFSSCASAKECFERDAWPKFPQPNSEETFLEDDISSLFYHSGPDAKEPQLDRNMEVDENVVKTFSNNDKARQHRMSWLGSASNRKKLNVTPDDVITADFGNGFVRSDKKAARRLTADRFQHRYWRGQPVRYVCKNLKTGQVYFVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUS2</accession>
    <name>A8PUS2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732166.1">
        <property type="nucleotide sequence ID" value="XM_001732114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUS2"/>
    <dbReference type="STRING" id="425265.A8PUS2"/>
    <dbReference type="GeneID" id="5856472"/>
    <dbReference type="KEGG" id="mgl:MGL_0759"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0759"/>
    <dbReference type="InParanoid" id="A8PUS2"/>
    <dbReference type="OMA" id="VSHHTPE"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="226" mass="23982" checksum="FB9C7B527EA63C75" modified="2008-01-15" version="1">MSVGEKKHISAPAWLMEFTANASESFVTAYYAASDSPQRGNLLPSLYLPNSSISWNGNPISGATQYKQWLETHPGSQHEIQSFDCHPLGPFDAYDQNVAPSLMLNVSGTVAHYTPESLATDQSNAPKSATSTGGASGHSSGGASSKRKFNADAPIETYPRVFSQSFVLINGAGTGAEGGVPFVWMPSRSSNGSGKGSKNIANSDKATETRTVAKYFIQADCFRFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUS6</accession>
    <name>A8PUS6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732169.1">
        <property type="nucleotide sequence ID" value="XM_001732117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUS6"/>
    <dbReference type="STRING" id="425265.A8PUS6"/>
    <dbReference type="GeneID" id="5856475"/>
    <dbReference type="KEGG" id="mgl:MGL_0762"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0762"/>
    <dbReference type="InParanoid" id="A8PUS6"/>
    <dbReference type="OMA" id="YWLASEE"/>
    <dbReference type="OrthoDB" id="5392202at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21373" checksum="E7CEF44B1A073F84" modified="2008-01-15" version="1">MAWEKRARSSWTVSFQQRRDSNSRRLSPEQLQDCFQAGSDLFDHIYSRQSHKLRQVLTHNHPDLGEYILNFQYGPLFAPASQYLHTSEPVWEVNRVRMSLVAIAALHAQGGVAPQVVSHIYGLLRARPVLEQMTKDAERESIEFLTSEHGAQWALQLVNEVCRVVEGSEDAERESSSPDTSASRPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUT3</accession>
    <name>A8PUT3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquinone biosynthesis protein COQ7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732174.1">
        <property type="nucleotide sequence ID" value="XM_001732122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUT3"/>
    <dbReference type="FunCoup" id="A8PUT3">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUT3"/>
    <dbReference type="GeneID" id="5856480"/>
    <dbReference type="KEGG" id="mgl:MGL_0767"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0767"/>
    <dbReference type="InParanoid" id="A8PUT3"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21579" checksum="636FA440BDAE0FD8" modified="2008-01-15" version="1">MFRVASRLSRNGLRQHHVQTRWFRTENLASDVFTKSTPSLAERAAKSESFLAALSPADRKAVSSMLRVDHAGEIAANTIYEAQADVFGFRGDQVTKRLMMEMWDNERKHLCAASAMLDEYRTRPSALTPAWALAGRILGGFTALLGEKSAMACTEAVETVIGEHYDEYVAHTFLYPANPLVNFFIWSRFARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVT8</accession>
    <name>A8PVT8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731685.1">
        <property type="nucleotide sequence ID" value="XM_001731633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVT8"/>
    <dbReference type="STRING" id="425265.A8PVT8"/>
    <dbReference type="GeneID" id="5855990"/>
    <dbReference type="KEGG" id="mgl:MGL_0953"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0953"/>
    <dbReference type="InParanoid" id="A8PVT8"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF2">
        <property type="entry name" value="VHS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="76003" checksum="13D94D60226A4875" modified="2008-01-15" version="1">MNPTSANASRSAAVASDASARRVDQECHPHHDQSYSEQRRPPSEVAGATQSMTIPTPEMLPSYPSYGEVYEQETYPDCTRPPPKEPRISTSHMSVTREMDQPRSSGSSSPDKRRTKPKFHLFRRPFHRHNEHDDLFETDSALDAALHDNSTPTMCPSHPHTESVHRVLGERPVAARYGVSTHIARATMDPDVVAHSVTEFCLADPTSLDWNIVHELGEHVHSGEAQSKAAMDAIRRILHSHKLRAQCRAIRAWGFWAMLGSGPFSTQAVHSRFLQDVEAILENPLTFAPLRNDILLVLGALAHRSKHNERLLRIARLWARVRPGASAEEGIPLSGPLFAIEDDDLSLSNDDMTDTPHMTTSGRPHLPAIPRTEQARPHVDMPIALMPGALLAPRSAPGHLPVTKGRGTPVSATGDAAVAAATLTKTAPTVATTTRARGMSDPGDTMAAPSDHITPTSLPTHLPHMTPDAWRTAGRRSPSATSHGVSTDSVRQNASSLWVQSQEPRSASDNSIMDDVRRSCVMAHSSANVLLDTLMSEEKDAALVQEFSEEAESQYARLESYLSWATERAPHEHADRDARQQDAEESLVDELIGAISHVGEALTLRDEFLTAATAAATAATPEPRGPVSPHQQRSKETAADPHILDTPMSPQESVLDIPMDGPVQPSAKALGKRRAVDPDMIDHTQKPPLPPLPLLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVY1</accession>
    <name>A8PVY1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0982</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731714.1">
        <property type="nucleotide sequence ID" value="XM_001731662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVY1"/>
    <dbReference type="STRING" id="425265.A8PVY1"/>
    <dbReference type="GeneID" id="5856019"/>
    <dbReference type="KEGG" id="mgl:MGL_0982"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0982"/>
    <dbReference type="InParanoid" id="A8PVY1"/>
    <dbReference type="OMA" id="FWKQTTH"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="131" mass="15153" checksum="5E1E0B618C6B6D50" modified="2008-01-15" version="1">MTTIPARLAKAAQVSHSLQHAQSRARSLYRSFYRSVPEICALYPLDVPPALLRAKIRTKFERYRNVTDVAVLDVLLLKGHQEYQETMNAWKQAPHVMQWFREEEAPAKPKSFLEKFYATRDEGRGPTHEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVZ1</accession>
    <name>A8PVZ1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731721.1">
        <property type="nucleotide sequence ID" value="XM_001731669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVZ1"/>
    <dbReference type="STRING" id="425265.A8PVZ1"/>
    <dbReference type="GeneID" id="5856026"/>
    <dbReference type="KEGG" id="mgl:MGL_0989"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0989"/>
    <dbReference type="InParanoid" id="A8PVZ1"/>
    <dbReference type="OMA" id="ELTWPLT"/>
    <dbReference type="OrthoDB" id="2593174at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="822"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="530"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="615"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="868" mass="97084" checksum="A50B6228B5703B12" modified="2008-01-15" version="1">MYNGGLYTPQPKSVGILRSPHTPGTGSSVRFGMRTYEDGEESLLTASVSSRAEDEDVRSHDMSISGDSMEMSFTESFLRREVDGALAGLDQSSSSSWKQPTTRPLTPIRSSSGAEAPETIKPLKSMIQDADDTSPWSSPSSPREGTSTSPLSSPTVRPSLRRAPTPDDHVEHRRRSLEDDTKPESDKNGIEMLAHKSDQDPAREPEKASAPSPERTGTVSEPQADSAEGTEMATEEQQADPRNDNDVVMAQAPREATVDQAPHDTLVQPEEPLDAAAPLSGPDPALVTHHEPLETVGSASTSSDPLAPASIHEGESSLTAQHTPTRPDASFASSSYSWATPRTESSARSASSPHTSAHWPGMYEFSYLTDKEELDDLDTGPLVPFAAQELSTKLFAIDSLADVDARELLDMVAALDRTHTERTIFLQHRLARSYRQCQILREQLRDANDYIHVFEGHVREFVRCKATWDEDDETKRATLQALTEQLESRLALLHTSTTTLWPEAITAPEPELTSKSTSAPAPTTSMDQQRQSTELDMERAELQKERAALEEERVNLQLQQAQLHDDWRKLDVGRRDLEVRRAEPSINVHEQVQQAIESTRQACMRDAEVRILVVRQEAADAVRELQARLTDAETQPSEAELLHAELENAKERTASMERHAGELKAQLQAQAKQIRAQEAWEAERLALEDVRAKAEMREKTARAELRQCEKARDETEAALKADISAWQQRVRTLEHDVAHRELDNVQLQKQRDSMKQELQTFTLALAAKDQELSMLKRGTQGSAYWDLITQRTRSERRPLQNTTNRVRSTQETVDKAQKMLHSTATFTDKWPRVPTISPRADEELSRKPTRASRRQLPSQSRPRHEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWP7</accession>
    <name>A8PWP7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731906.1">
        <property type="nucleotide sequence ID" value="XM_001731854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWP7"/>
    <dbReference type="STRING" id="425265.A8PWP7"/>
    <dbReference type="GeneID" id="5856211"/>
    <dbReference type="KEGG" id="mgl:MGL_1174"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1174"/>
    <dbReference type="InParanoid" id="A8PWP7"/>
    <dbReference type="OMA" id="ANIPWGP"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="7">
        <location>
            <begin position="41"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="433" mass="47088" checksum="DB2EF98712FCE54C" modified="2008-01-15" version="1">MSDQQLLQISPSYYAVPPEQRPSTGTVPKDVQESHEKIPLLFQPTEITCGNKKMVLKNRVIVSPMCMYSSVDGFPTPFHLVHHGQFALRGAGAIVVEASGVSPEGRISPRDLGIYKEEHVAAHASLVSSVKSLVSGVHIGIQIVHAGRKASTWPPYQPQPSAEHANVPTSEGGWEDNVVSASALPFDHTHVTPKELSLQQIHEVEDDFVRAAERAFRAGYDFVQIHSAHGYLVSSFNSPLTNKRTDEYGGSFENRTRLLLNIVRRIRQQFPDRGVWVRINGTDGLPEDSKDESWTSESTKAVAPLLEQAGVDMLDVSSGGTIGSIQLRASPGYQVPGAIAAKAGGLQRMRVSSVGALNGGTPEDPSREGLFAEKVLQSGDADFITLGRAFLRNPCWVEDAARNLMGVDPVCVLQYGYAYPRLSPRSNTDDKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWV0</accession>
    <name>A8PWV0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731958.1">
        <property type="nucleotide sequence ID" value="XM_001731906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWV0"/>
    <dbReference type="FunCoup" id="A8PWV0">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWV0"/>
    <dbReference type="GeneID" id="5856263"/>
    <dbReference type="KEGG" id="mgl:MGL_1226"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1226"/>
    <dbReference type="InParanoid" id="A8PWV0"/>
    <dbReference type="OMA" id="AQHFPRK"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="6">
        <location>
            <begin position="226"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33728" checksum="78BC1CF006ADA943" modified="2008-01-15" version="1">MGFAPERVDWALHSTNGTLEAALDHLEAHQDEAIPADAMAAAPQPTSAADPHSTEAPEVNSIRCNVCEKVFRDMDLAMYHADKSGHEDFSESSEKIKPLSPEEREKRLQELRTRAAEKRAVKEAENAREQRANELIRRKAGQDAGQAREELERKERIKEAERKRRERLDDIAAKERVRQQIEEDKRRRAERAAREKELRQGIQTQATPAEGVPSLAAQLAKTSQASAGSETRLRVRAPGGTWMGTLSVEATLADVEKAVISDGKGGSGSSLTFSTTFPRKTFSQDERSQTLKALGLVPNAALEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWY0</accession>
    <name>A8PWY0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication ATP-dependent helicase/nuclease DNA2</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">MGL_1256</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731988.1">
        <property type="nucleotide sequence ID" value="XM_001731936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWY0"/>
    <dbReference type="FunCoup" id="A8PWY0">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWY0"/>
    <dbReference type="GeneID" id="5856293"/>
    <dbReference type="KEGG" id="mgl:MGL_1256"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1256"/>
    <dbReference type="InParanoid" id="A8PWY0"/>
    <dbReference type="OMA" id="NYCEAAI"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000721">
        <property type="entry name" value="DNA replication ATP-dependent helicase/nuclease DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0347">Helicase</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="22">
        <location>
            <begin position="135"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="23">
        <location>
            <begin position="751"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="23">
        <location>
            <begin position="848"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="24">
        <location>
            <begin position="926"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EDP44774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1210" mass="133937" checksum="0FE3F2D090E809FA" modified="2008-01-15" version="1">MDGVEEEFFHQLLDSLPGPSSSARSIRNAPHDAFADGLSQQLPSLTKACSEKDVPVLNQQSHRAMLATRAYSRARVVKVYANEYSGIRGIQIEKILELDITHGLIPSTKCTSPLSQSMYFQPELHHFPAVHGYARLRDQWESTFVKPDDTVHLIGEWDSEDGVPCMILSTFSHSSTKESVRLLVVHPDVIISSSRLASVASCMRKSMLQERIRSPTESTYVAVLGTMVHSLLQACLTGSIDPMHESPAPSPEVSAPAKWDRIGNFSCAFITAEIERQLEEAQQALVLVDTKTDTARRDLIAAVPSLVRFAETFLSFRDDSRRKAMAQIHDTRMNAHIRMCITRIIGTESDILCPMYGLKGRLDLCLEAEIETSAGGRKCILPMEVKTGRITSSMEHTAQTSLYTMILADAYGVSVDYGLLFYVQNSEIRPVHCNTKEVRSLIMARNEMASFKVQLALLPSPTEGTIDILPQQSVDPAHVSAPSEPAEVPTPASEDSFEFDLTEADLEDLACDVSPRFLPATIDNKYKCQRCYSRDSCMLYRRAVEHVSDTESPIADLYADSTDHLTPEDMAFFAHWDALLSHEERGLLRFQHELWTMPADARAATGRCVPNLMMIRKMDGLCAFSIPASKVAFMPEDVVCIAVQTPVTAFLLRGRVVASTTQFHVRPESSLDLALTQYESQYGKPQTFRVDLDDIMSVMGVPRYNLACLFYKQVTPQITMLRRRVVHLDTPQWTCINDKMAAFVQRHAASCNADQRHAIERALCARDYTLILGMPGTGKSTTIAVLVRILADMGQCVLLCSHTHSAVDTIVSKLLDIPVLRLGPLSRIHPRVHACALATKLGPQASAEALVDLVQDAQIVAATCLATNDAALARRTFDVCIMDEASQITVPTCLGPLRLADRFVMIGDHHQLTPVVRNTDAASHGMSVSLFQRLCKAHPDSVAMLCMQYRMNAEIMALSNALVYEGRLSCGSEDVACARLIIPSCDQKKDCATDNEAGIAAMLEAIIDPSRPCVFVDTDPVHAEESRTDTLVENEAEAAWVARIIEALRQAGVQGTDVGVLTPYRQQSKRLRDACASTEVLTIDQAQGRDWPVVLVSLVRSNTAHVAGELLRDRRRVNVMVTRAKTKLILVGSQSTMAADHASHSPMRELVRLLDEKQVIVSLHKEAHKSIDIPSRMSPRRQRPVKKARGVLVRRPVLTEVLHEHGLTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX13</accession>
    <name>A8PX13_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1289</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732021.1">
        <property type="nucleotide sequence ID" value="XM_001731969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX13"/>
    <dbReference type="FunCoup" id="A8PX13">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX13"/>
    <dbReference type="GeneID" id="5856326"/>
    <dbReference type="KEGG" id="mgl:MGL_1289"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1289"/>
    <dbReference type="InParanoid" id="A8PX13"/>
    <dbReference type="OMA" id="ADCVQQF"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="18"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="219"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP44807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="471" mass="52984" checksum="2A0AB4337C44E697" modified="2008-01-15" version="1">MCFETPGAKENVLHEKEKHFEKLLSVSDETLQEINRNFVKVLSRGLEQEDQVVPMFPTFVFNWPTGKETGDFLSLDMGGTNIRTCLVRLKGDRTFELTQSKFRIQETYKHVDGQILFDYFAECIRDFIEQQYGSCDNISEDLSLGFTFSYPTVQKKIDHGVLTHWTKGFGNPNTEGHDCADLLRQSLKRARVPVKLSSIINDTTGTLIASNYVEPDTQIACIFGTGCNAAYMEDVSEIPKLAHLNLPPNEKMAINCEYGAFDSFDHKYLASVRTKYDEEIDLTSNKPHQQAFEKMIAGLYLGEIFRLIVCELIYEGVLFLGQETYKIEKPFSFDTAFLSLLETDPTDELLTVMGLFKYFFGLETELDERQFFRRLAQLIGTRSARLSACGIAAIVSKKNLLEKGCTVGIDGSLFSKYPHFSDRLHEALEGILGPKAKSIKTRQAEDGSGAGSAVIAAMTTARKKEGHLVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXA0</accession>
    <name>A8PXA0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731193.1">
        <property type="nucleotide sequence ID" value="XM_001731141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXA0"/>
    <dbReference type="GeneID" id="5855500"/>
    <dbReference type="KEGG" id="mgl:MGL_1376"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1376"/>
    <dbReference type="InParanoid" id="A8PXA0"/>
    <dbReference type="OMA" id="VIQEWAD"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="97" mass="10512" checksum="19C47F25A438AD3F" modified="2008-01-15" version="1">MSSKAEVIQEWADLDANGASFERGRMEANIQSICFLDPAGVPEAMKDRHKGVKVKSADVLTLTSELLVEPEVAEYALVAAAGDVEQAFHLLMRHASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXB3</accession>
    <name>A8PXB3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731206.1">
        <property type="nucleotide sequence ID" value="XM_001731154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXB3"/>
    <dbReference type="STRING" id="425265.A8PXB3"/>
    <dbReference type="GeneID" id="5855513"/>
    <dbReference type="KEGG" id="mgl:MGL_1389"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1389"/>
    <dbReference type="InParanoid" id="A8PXB3"/>
    <dbReference type="OMA" id="IEWPMSI"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052467">
        <property type="entry name" value="Sorting_nexin_PX-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15813:SF9">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15813">
        <property type="entry name" value="SORTING NEXIN-22 AND 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="205"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30976" checksum="F416912DA40FA030" modified="2008-01-15" version="1">MAAQKNELDSCVPIQQIAVPLYERREKPNPHIVYAVQVTLPDRTWTIRRRYNDFCLLHERLPSPAPPAPLPPKHRLKQTWRMLTQMGGILPTSDAQKLDDDKDLELRREALEKYLRAIVVSPDAHWRESHAFIEFLDVQDHMQLHEQSQATSASAGKPRIMSSGMCSASLRPWNQHSKSHENAKARETDATRPLTDAELLQYQTDDLMRAQDKQADALAIVLRRQRELGLRIHDELGMHREMLDSLHTDVQSTQTRMDAAEAEMKRLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXJ0</accession>
    <name>A8PXJ0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731275.1">
        <property type="nucleotide sequence ID" value="XM_001731223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXJ0"/>
    <dbReference type="STRING" id="425265.A8PXJ0"/>
    <dbReference type="GeneID" id="5855582"/>
    <dbReference type="KEGG" id="mgl:MGL_1458"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1458"/>
    <dbReference type="InParanoid" id="A8PXJ0"/>
    <dbReference type="OMA" id="ANSHIMN"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0117">Actin capping</keyword>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="96" mass="11216" checksum="FCDD222DC3B84E78" modified="2008-01-15" version="1">MLTLKRQEPTTLGLVDMSGHLTREGEDTQSVTDANSHIMNIGRLIEEMENKIRNQLQEIYFGKTRDIMDQLRSIEDLEAMRLARQVQEELRGGWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY97</accession>
    <name>A8PY97_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET3</name>
        <name evidence="13" type="ORF">MGL_1619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731436.1">
        <property type="nucleotide sequence ID" value="XM_001731384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY97"/>
    <dbReference type="FunCoup" id="A8PY97">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY97"/>
    <dbReference type="GeneID" id="5855743"/>
    <dbReference type="KEGG" id="mgl:MGL_1619"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1619"/>
    <dbReference type="InParanoid" id="A8PY97"/>
    <dbReference type="OMA" id="MEMRYAG"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="174"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="397"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="9">
        <location>
            <begin position="171"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="397"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="436"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="575" mass="63711" checksum="A808F59690B082EC" modified="2008-01-15" version="1">MVNPPHGGVLKDLLARDAPMAEKLREEAESLPEIMLNGRQLCDLELIITGGFSPLEGFMNKADYEGCLTNMRLASGALFPIPVTLDVSKEQVETLGLKEGARVALRDARDDTIIAILTVSDLYDVNVSREAELVMGADDKAHPAVAFLYQNAKDYYVGGNVQAVAKPQYFDYVELRYTPAELRHHFSKLAWPQGQWPSQTSNPMHRAHRELTVRAARQLQANVLIHPVVGLTKPGDVDHYTRVRVYQSLMPRYPKGMAHLALLPLAMRMAGPREALWHAIIRKNFGVTHFIVGRDHAGPGKNSQGEDFYGPYDAQDLVKKHTDELGIEMVPFQMMTYLPDLDEYHPVDAVPEGAKTLNISGTELRKRLRSGAPIPDWFSYDSVVKTLRESYPPKTSQGFTILLSGLLNSGKDQIASALQVKLHEQGGRSVSLLLGDTVRHELSSELGFSPEDRHKNLQRIAFVASELTRAGAAVIASPIAPYEHSRQMARDTILKGGGSNNFFLIHVATPLEYCEKHDRRGNYAKARRGEVKGFTGVDDVYEAPKDADLVVDLSQQSVAEITHSIVLLLEANGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYC8</accession>
    <name>A8PYC8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731454.1">
        <property type="nucleotide sequence ID" value="XM_001731402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYC8"/>
    <dbReference type="STRING" id="425265.A8PYC8"/>
    <dbReference type="GeneID" id="5855761"/>
    <dbReference type="KEGG" id="mgl:MGL_1637"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1637"/>
    <dbReference type="InParanoid" id="A8PYC8"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="321" mass="35181" checksum="CF2EA692A5021418" modified="2008-01-15" version="1">MRGRCNPPPWAPWFGGGPDVTSSEMPGSSSGPGRRAPVREAAPLLRRSRTTESFVHPMSSLLPPSPPPSPPPMYRFNPIHVHHGAVSRGVDSVQDTNDDDHVQYDMGRGSDDYVLDEGGERHSERHCSRCRDHHSSMTSNAALAPLISPTAFIRTSLQLASRFDVPGTPDMSPANMDVRHQPTAMAEAFLRRIFVNWNASGAYKAEDAGIELLCPGWTGAVVQKNTCTTRSAQLRSLYVHMPRSFDRSTLRDHMLRILDAASDSVCASRVVFCLERDIPDLSSLLHGLCYVGGQLSSLQGQRDEWMQATPLASLVLVAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYF3</accession>
    <name>A8PYF3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731468.1">
        <property type="nucleotide sequence ID" value="XM_001731416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYF3"/>
    <dbReference type="FunCoup" id="A8PYF3">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYF3"/>
    <dbReference type="GeneID" id="5855775"/>
    <dbReference type="KEGG" id="mgl:MGL_1651"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1651"/>
    <dbReference type="InParanoid" id="A8PYF3"/>
    <dbReference type="OMA" id="NQWFFTK"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="136" mass="15744" checksum="F6FBD3D1BCA4C907" modified="2008-01-15" version="1">MPKIYKPGKVAVVLQGRHAGKKVVVIKQQDEGTKEHGFPYVVAAGIERYPLKVTKSMSSKKIARRSKIKPFIKVINYNHLFPTRYALDLEGLKSTVSNDTFKEVSQREEAKKAIKKLFEERYQSGKNRWFFTPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYR4</accession>
    <name>A8PYR4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731527.1">
        <property type="nucleotide sequence ID" value="XM_001731475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYR4"/>
    <dbReference type="STRING" id="425265.A8PYR4"/>
    <dbReference type="GeneID" id="5855834"/>
    <dbReference type="KEGG" id="mgl:MGL_1710"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1710"/>
    <dbReference type="InParanoid" id="A8PYR4"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="96" mass="11031" checksum="AF7A302A7FAE65DE" modified="2008-01-15" version="1">MGWNYRRWVVEELAKAMSKVDGIPPFPASLSSELDPETRTMHLALAYQELKYTLAKIESDFSNFSAWHSRSKLLPRIWDGERLDSCARSKQRISGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYV4</accession>
    <name>A8PYV4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731547.1">
        <property type="nucleotide sequence ID" value="XM_001731495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYV4"/>
    <dbReference type="STRING" id="425265.A8PYV4"/>
    <dbReference type="GeneID" id="5855854"/>
    <dbReference type="KEGG" id="mgl:MGL_1730"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1730"/>
    <dbReference type="InParanoid" id="A8PYV4"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000007">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="625"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="655"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="691" mass="74418" checksum="97DB3E00A752B09E" modified="2008-01-15" version="1">MTRTMEQPVLYIPGSNVTMPQLAGQVGSSWNGISSCDPSMQTNPAPSNNPAEPPIINVSEAGPLPSGQDPMAMMNVFGSSSPLCPKQGAYASHVSKSVILGNQEDLSSSMSVYYSPDSAMSSGTPCFSTRQTGPENVLDPTNGVRRQDSSNLKGFLKLDVNMGFMGDGKIDSPTSGLQPVIGWKKRRSVSDVGPRTPSMLGPSMDALPSPIDDLSYLINSMGSRAQTDRPSMNLTHSDEQDSAFNFGSLNLHAEKHPVSHVASQSTASAPGAMEGDGDATSMTQAKSSLQNTLEQAGKSAATLDPSYIPTMMNPTPLVDSSIVDALSSQNLYETTLEDAKEESSTGPIRTCPSGRSSRSVSPYHASTRSLTPESERSLEESAIYDSALRMSQWRFPLNNSQAGHKSDSLHPLDAYGHAVNTSTLTFPGSVRYPGHPRSARRHMRAAISEDFHGRVRVGGISSWGNSLDLTHQGFPLLNHLPTTGDSQVLSPAMVRCASSPGKPSEFQASPAGQVMDTGNISDPNDKLDLERSKNEPQLKPELSSQMVDSSPSRSKVKVEPMDNALQTAAQTHTPVVTTTAAQAASASRRKAEALFTCPFPDCGSTFTRQYNLRGHMRSHMDERPFKCEWPGCGRSFARTHDCKRHHNLHLNIKPYQCESCGKTFARLDALNRHHKSEASTCGAKLHESKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZF6</accession>
    <name>A8PZF6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730916.1">
        <property type="nucleotide sequence ID" value="XM_001730864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZF6"/>
    <dbReference type="FunCoup" id="A8PZF6">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZF6"/>
    <dbReference type="GeneID" id="5855223"/>
    <dbReference type="KEGG" id="mgl:MGL_1915"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1915"/>
    <dbReference type="InParanoid" id="A8PZF6"/>
    <dbReference type="OMA" id="DTWIMRR"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="960" mass="106922" checksum="5C20794BC681FDAA" modified="2008-01-15" version="1">MLLPRRGYAWACQGARRYVHASICTRRVQRKSTKDLPVHAHKPIPLKHSEPGGTTISHDWPPLALGVLENMRAFPKCILLTRVGGFYESYFDQAPTVAQTLSIKLASRKWAGQSIPMAGFPIHQLEKYLKVLVQDCGMLVAICEEFKASLSSGAPSFQRRVTRVVSPGTLIDERFLDPFHNNFILAVSSPPPLSPTPSSSLPSSASAPGSTLSAGRSYGLAWLDVSTADFGTVVHNDEKTLRDEIVRLAPREVVLIADAFDASHPVYEATNRVQAPVAFVPTLTHAQENILGVSQANLCDAERKAIEILTSYLQTRLLEHMPGMSVCEEGGSARASGDYVMHLDAATLNALEIRETQDHSARGSLVSIVRRTVTQGGARLCVQWLTQPSMSLRLIRARHALVELFLQRSFLRQDLRVLLRTGVGDIMRTLQRISLRRNDEQDLLEIRDFIRTSERLVASLASIDVHELHELLQRFTALHALGERLEMAIDERVMEKRIQQQEARLQTYDAMYAGGPMPPADASAPSKRTRRTSSPPSLTLPESMWGDNIEHLIRPDASPLLLTLTNEFNALRAEARTLENALRAEHSEPVTLRFLLGQGHVVHFPSVRGHVSESLSLAYKTKTTRTYYHAEWTRIGTQLQKLRDQLSECERRMLETLRLEVLEHTAALRRNARLVDQLDVLLGFAQVAEELSLVRPQMDESTSFDIKGGRHLGVEMGLLERERLFTKNDLELGGQARLHLVTGPNMGGKSTFLRQNAVMAVLAQAGSFVPAESARLGLVDAIFSRVGAKDDLFHSRSTFMVEMAETAELLHRATQRSFVIADEIGRGTNTSVGLSVAFAVLYTLAMRIQCRSLFATHYYELADILEKHPSSSQLPQTQALRRAVGFFCTRLEQRSDGALLFSHRVRPGVNRASHGLDIARLADMPPDTMELAVRTHSWLVKHGQAHMRTHGLVDQVLMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZH3</accession>
    <name>A8PZH3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730920.1">
        <property type="nucleotide sequence ID" value="XM_001730868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZH3"/>
    <dbReference type="STRING" id="425265.A8PZH3"/>
    <dbReference type="ESTHER" id="malgo-a8pzh3">
        <property type="family name" value="BD-FAE"/>
    </dbReference>
    <dbReference type="GeneID" id="5855227"/>
    <dbReference type="KEGG" id="mgl:MGL_1919"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1919"/>
    <dbReference type="InParanoid" id="A8PZH3"/>
    <dbReference type="OMA" id="AIFDWSY"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="4">
        <location>
            <begin position="135"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="396" mass="44450" checksum="C2D4E144055740FA" modified="2008-01-15" version="1">MYGIAWTSYILLAQKDRPSYTMLGVPSLTKYIPFLPVTPQRCFKVTKAVLGYIWSCCSIMNMAKNWFLLYKQHKARPGSESIIYSMPFSRKQLDVYPPTSSTVDASDVRRNAPVLVLVPDAIVPVTLTSHRKMYLPLATRMQQLGYCVVVPQITYYPADQIRQSVIDLRLALSWVGAHIFHYAGDPSRIYVMGHGLSAELVALTLVQEAVVLSQTIKKHRDIDDATNHDLTPKSNIIEPETFNKHLEIYAPQVRLPNIAGVILLAGHSDVIKSNLNEADLGIEHLSSHRRWTGPQQFQCLLHSPTHLLMHSKACLDPTFLPPKFLLIHGGLDKLVPISQAILLRSLLLEIGVKNAELLAFREMNHFDTFKLFLASPPLASSKYEIAILKSICSFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q000</accession>
    <name>A8Q000_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_1966</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730967.1">
        <property type="nucleotide sequence ID" value="XM_001730915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q000"/>
    <dbReference type="FunCoup" id="A8Q000">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q000"/>
    <dbReference type="GeneID" id="5855274"/>
    <dbReference type="KEGG" id="mgl:MGL_1966"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1966"/>
    <dbReference type="InParanoid" id="A8Q000"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9 13 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="59"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="142"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP43753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="908" mass="100656" checksum="2999FE2B1C1D206D" modified="2008-01-15" version="1">MALPHRRTHLGVRAPSRTAPATASMAGTLRPGVPNRSGSGAQQQQRQLSQGDLRRTETSMRVMVRVRGTASTGNSVLVTEGARGERITVIQETQPSSSRTKTYAFDHVLSAEADQNMVYTDAVGSLLDDVLLGYNCTVFAYGQTGTGKTHTMEGDLASYMETYAPEAGVIPRTLYRLFHVLESRGDDYAVKMSLIELYNEELRDLLGDEHASTQLRMYDDPRGRGVVLQGLEEVPLTSAAHGLSLLRYGSERRHVASTLCNHTSSRSHCVFTLTVQIKDTGARGEELMRIGKLNLVDLAGSESIGRSGAENKRAREAGAINQSLLTLGRVINALVDGSTHVPYRESRLTRLLQDSLGGRAKTCIIATVSDDRDNLDETLSTLDYASRAKSIKNRPEANQRMTRTALLREYVTEIDRLRSDLVATRARNGIFVSEDNWARMETEQGMLKRQVDEYRRAADVAASRLTSMQEQLEQNTRVLAKREADAVQAETKLRTCTEQAERDISSLEEQLARRADVDAQTRTAMSDLVQQLHEARFHINACAGIDIRQTLSSLSEQVQSQASSIQNIIHEYLTAFPALDKPAIKSLAASVLQLMTQQLHGLYSTHMDTADRMSSCLETHTSRVSDLLYASEQVVRAWDQASTQIEQHVDSLTHHANDGLTRAQARAALETQQWNDVRHSVQLETESLRKTLLSAIDSFALTQDERLERHLKAAKLAEHAAMHERETLSKLMSEYTSTASDTQRSKDAATQHLDKTIELVRTSGHDEALQWDSHRRGLSLSTHATLDHIVSSTRSITEPMETYMDAADASSKAATQAMRRVQGALNFFDARAVASSVRDEASILQTAMSNVTDRLEQAIAPLATDRLREASPLVTHEPNVQGRTNMPLQERPSQENIIPAVTPLKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q039</accession>
    <name>A8Q039_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730979.1">
        <property type="nucleotide sequence ID" value="XM_001730927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q039"/>
    <dbReference type="STRING" id="425265.A8Q039"/>
    <dbReference type="GeneID" id="5855286"/>
    <dbReference type="KEGG" id="mgl:MGL_1978"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1978"/>
    <dbReference type="InParanoid" id="A8Q039"/>
    <dbReference type="OMA" id="NEFEATH"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725399" description="Thioredoxin domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="163"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="579" mass="65125" checksum="11A7D31C14890CDC" modified="2008-01-15" version="1">MHRLAFVTIVLALWSLLHVSAAPIDDVFGVERSLSLGNFSLTNRGTWLVEYYAPWCPHCRAFAPKWHELVQRVDFMAQETENPFTLARVDCVEEAELCGQEHITGYPSAKLYKNGKTVENNVFKIVSRDIDRLEEYIRNEFEATHPAFAKNAALNNAPSGSGSGSGALVPVTHLTEFGMRPIETIEQLNRYFGPDHGQGPSFVKYYSPSCPHCRAMAHDFELAAREMVGQVNPIAVNCQKYSDVCAEHDVGGWPHMRLMNDGNSIVYPDFGREKDDFLNWLREQNVLDAVRPVDSKSWFKKIKMKKQSVLHLMPQSDLEVQLLDEVKSRVKTDMQFLVSSDRTLSRRFGDSGAILVFNDNPYRPMAKLPLSSITMNIDQGTADTVARWLDMQNEPLLLELTGPDAGESLHQDPPTVLAALSSEKSATVLELQLQQLRSVAQSWRSSPDLSRQPLRFRWFDVDGREANPLKVIYDIDVKSVPSLYLVAGALGTPYKYPKSSRWIKQDKVIKWLNDVQAGRVANGLDDSLLARTLSVGSAAEEVNPVLIVLVVIAILCVIPRTRRFLLRLFSGTRANRKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q051</accession>
    <name>A8Q051_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730984.1">
        <property type="nucleotide sequence ID" value="XM_001730932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q051"/>
    <dbReference type="STRING" id="425265.A8Q051"/>
    <dbReference type="GeneID" id="5855291"/>
    <dbReference type="KEGG" id="mgl:MGL_1983"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1983"/>
    <dbReference type="InParanoid" id="A8Q051"/>
    <dbReference type="OMA" id="HTRGREI"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="60559" checksum="B4056259C665909E" modified="2008-01-15" version="1">MQHGSPAYLSAFTNHTRGREILATWLSDATPPRKSDMEDISDMYATVVEPLLALLLRLPIELEHLKDHVGLGKLITGAQKRLRSEHARKLADEVKEKWSALVPSSTASRAQSAPPLSTTVKRPAATNSLQDPTTKRARSNSASTAVPPTRSAVGASVRPASSMLMSGTSRARTASASTQSERRGSPQISDAKPLTSSSAATRRSVSSRSASAQSNANRDLASFMTLIDQPRPSPPPTASASAPVSAGEASSTSSVESGTQPKKRKKTVHWRDHDGQALVAVKLIEPAVYEEDEQGGIASVGQLDMEEGGAFRLAHADMEEYIDYYPPREVSLSVLSPMIPECGAHSEAKQIQAEYENDVAEVTYSEPSMIPESPAEPVQDAYLSAFSTTLNEPRVMTTGSVIRPFVFDQISSPSVSTSSSSSIPGLPSNLADLLQQLKDESTTATSSPTTSLTAPTLSEVPKTPPAAMPMPMPVPTSQPSMPSDAPTNESTIPLPLPLSPWGGLPGMLPPPWPFPSLPTSEAMTTMQTTVAPMNMPEPDSKTPSETTRSRAGRPKRTGKYSRPLEGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0D6</accession>
    <name>A8Q0D6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">MGL_2017</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731018.1">
        <property type="nucleotide sequence ID" value="XM_001730966.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q0D6">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0D6"/>
    <dbReference type="GeneID" id="5855325"/>
    <dbReference type="KEGG" id="mgl:MGL_2017"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2017"/>
    <dbReference type="InParanoid" id="A8Q0D6"/>
    <dbReference type="OMA" id="WDGPAAM"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000160">
        <property type="entry name" value="Glutamate synthase (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="26">
        <location>
            <begin position="64"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="873"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1467"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1467"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1658"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EDP43804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="2055" mass="225669" checksum="2AE595807E7AAC47" modified="2008-01-15" version="1">MASSSEFVFARNHTKDNDIVSEYLSSEDLQDSGYESVVRDSESWAGAMPASQGLYDAQYEKDACGVGFLCHIKGKASHKIVSEARFLLCNMTHRGATGADARDGDGAGVMTGMPDAFLRREVAIDHDFELPPVGQYACGNLFFTSQDDQARAEHIQLFETIAEKLGLRVLGWREVPVDSTILGPASHSREPKTMQPFVVMGDHYGWTSKKCEMNGGSFDDKHFARQLYVLRKHASHRIGLANWFYICSLSPTNIVYKGQLSPVQVYNYFHDLNNSAYSAHFALVHSRFSTNTFPSWDRAQPLRWAAHNGEINTIRGNKNWMRAREGLLRSEVFGDDLDLLYPIIENGGSDSAAFDNVLELLVINKVLTLPQAVMLMVPEAWQGSEKDPAKVAFYQWAACLMEPWDGPALFTFCDGRYCGANLDRNGLRPCRWVTTNDDIMVNMLMLPMINDSKEALGSMGSDAPLACMSQTPRLVFEYFRQLFAQVTNPPIDPIREAVVMSLDQYIGPEGNLLEMNEKQCNRIYLQSPVLSMEQMAALRQMHLVYPEWKSVTVDTTFDHALGVAGYEATLDRVCAEVSHAIEENIRIVVLSDRHVGPHRVAISSLIACGGVHHHLIRQKKRNRIALVIESAEAREVHHVCVLLGYGADAICPWLAQEAVLKVHREGLSKTDVPAAKLTENWRAATDSGITKVMSKMGISTLQSYKGAQIFEALGLDNSVVDRCFAGTASRIRGATFEVLAADALEMHEQAYPRRHTVGFEGLPETGDYHWRDGGEPHVNDPNCIAHLQDATRTKNQAAWDAYTKASHNMTKATTLRGLLDFDYGKARPIPVDQVEPWTEIAQRFCTGAMSYGSISMEAHSALAIALNRLGGKSNTGEGGEDPERSIPLPNGDSLRSKIKQIASGRFGVTSRYLSDADELQIKMAQGAKPGEGGELPGHKVSESIARTRHSTAGVGLISPPPHHDIYSIEDLKQLIYDLKCSNPRARVSVKLVSEVGVGVIASGVAKAKADHILISGHDGGTGAARWTSIKYAGLPWELGLAETHQTLVLNDLRGRVVVQTDGQLRTGRDVAIACLLGAEEYGFSTAPLISMGCIMMRKCHLNTCPVGIATQDPILREKFAGQPEHVINFFYYLSEELRSIMAKLGLRTINEMVGRSDLLRMDEAARTPKTANLNLSALLKPAHEMRPGAATHKVRQQDHRLYVRLDNKFIDEAEPALSRGLPVQIDCHVVNTDRALGTTLSYHVSKLFGGDGLPRDTIHISAKGSAGQSCGAFLAPGITLELEGDANDYVGKGLSGGRLIVYPPKSSSFMAEENVIVGNTCLYGATSGHAFFAGIAAERFPVRNSGAHAVVEGVGDHGCEYMTGGRVVVLGSTGRNFAAGMSGGIAYVLDMNRDFASKCNMEMVELGSVQEPQEIAELRMLLEDHRHYTGSSLAEHVIHEFHHLLPRFVRVMPTDYKRVLEQEAAKAAEEKKRSSHVDLRGTLSRRGSQVDVTMGDEANAHATPDVALPVSTEPAVVDMEEAMLDEELTKARTEKLDKMRGFMKYHRRGESYRNASARVKDFKELSSRLTEPELKLQTARCMDCGVPFCQSDNGCPISNIIPKWNDLVFKGQWRDALNRLLMTNNFPEFTGRVCPAPCEGACVLGIIESPVGIKSIECAIIDHAWEQGWMVPRPPPQRTGKTVAVIGSGPAGLSCADQLNRAGHTVVVYERADRIGGLLMYGIPNMKLDKQVVDRRVNLMAAEGVQFITNTEIGKDVDAADLHKQNDAVVFATGATWPRDLRIPGRDANGVHFAMEFLSSTTHSLLDTQLAEGTYLNAKGKHVIVIGGGDTGNDCIGTAVRHGAASVVNFELLPQPPAARAENNPWPQWPRVFRTDYGHSEVKARWGNDPREYCISTTEFEKDASGNLIALNTVRVSWELDASGKWQMTKVPGSEQRFPCDLCFLALGFLGPENAAIESLKLKQDARSNILADTNRGERPYKTSVDRVYAAGDCRRGQSLIVWGIQEGRACAAQVDTDLMSSSYLPWAGSIPKRIHVADEPASAALATKRQSITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0V7</accession>
    <name>A8Q0V7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731089.1">
        <property type="nucleotide sequence ID" value="XM_001731037.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0V7"/>
    <dbReference type="GeneID" id="5855396"/>
    <dbReference type="KEGG" id="mgl:MGL_2088"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2088"/>
    <dbReference type="InParanoid" id="A8Q0V7"/>
    <dbReference type="OMA" id="HMPLGWS"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727944" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1311" mass="143157" checksum="1D751FF813201F2A" modified="2008-01-15" version="1">MKHRVPPWRSKVLTISLVLCFSWTHLVQVLADVKVGLELAEQLPPLAHKDYSYNWQFSPETFTVDSDAPLSYSIEGLPAWAHFHASELRITGQASKKGKQDEINNVKVIAEDGNSQATSSFQLVTISAPPPKLNISVQDQLPKAASMGEGNMLADKVLHMPLGWSFSIGFLGGTFVLPENDRVYYSSRLVGGRPLPSWLNFNPDDITYSGIAPTSAGKRGTSYDIELIGSNRPNTGGPSSAFTLLLGEGFVTLNNSAAALPVGNVTEGDTLEYHISQDLFLLDGFSQSPNEFTFKLDSDAPDWIHYDAASQNLTGKVPFDGNNTQLHHDTFKLHVSHPNAFDTVMNVTLDIFPSPFKRPMLPNVTVQTGRDFRVSLEDYLRDANVNMNVSFDSMMRRRSMRYRDSRPTHRWVRRNAPSWVHYDDETHSLVGQAPDSEQRVTVHMSADNPVPNSPIPPASQSFQLLVHNSTRVNHTEPIHPHSGLTSGEKGAIAGSILGAALLALVAFASWWAWKRGKNGSDAMDPSVDATSESLKEGITSGPSSIRNANYTDLGPGTSSDLADTSEIRDSLHPSSPASTAGAAAAGGTATATATAAAASGKNKATDKSTGDLSLGTQSATRVSPTDEPYVTPPGSAGNSTRSDRNYEQQHPRQHEFFPGVTQDLPYNEPEWQRDDDQIIITPFLAQSSWQPPLFTQMWGSKPYETGFKAYTKGPDRAESRTKTMASSPEVPESSHTGKSPKNFNNGDHVSDDTSLPAGVSDRHRRSARVPAQITYRPSSPEPDTTGSEKNDLTTKNHMGFMAENTNSLSDQPNEIKSSESNLPQRASFLADFEPRGQKDGSKPSHPEEEPSLSQKNTPRHIPASISKQSQESWEENLWYEMPPAPKRMSQMQQRRISSPVTLPSATALDTQPSRSKPVVDKPPRLETPLRNRLSPIQMDLAAASTRSQAATTIKPVETSSRHTSSNLSPPIDQSSFEGVPQLAPIASSVVRSPIMPDLDDPPQVVLPLENNKRSPLDAFVAPATQPMDIEKTRHVASYTPKLESGPLDRRSQSLNAEQLDSAGVFDDADEYVLDPFADEQYPDGTVLYQEQQAASNDDHTTDVTSSGHLNDYLTTEGGMYSIIEHDDGSDQSQPDARNNATAAPTQPPRSGTMASIQMAQTRSVTFTPAKPPRLQLASCRPGQFIALPLMTSDASVPQNLAEAIQKASSPARYIPQLFAPSRPDLHGTWPEWLAWLAWNDDAQELAGTVPEQWPEKQRLPIQLPIHIQLSNGRQILQESGVPRHELPESSVPLLAARILLTILPAASPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1U4</accession>
    <name>A8Q1U4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730841.1">
        <property type="nucleotide sequence ID" value="XM_001730789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1U4"/>
    <dbReference type="STRING" id="425265.A8Q1U4"/>
    <dbReference type="GeneID" id="5855148"/>
    <dbReference type="KEGG" id="mgl:MGL_1840"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1840"/>
    <dbReference type="InParanoid" id="A8Q1U4"/>
    <dbReference type="OMA" id="DAKKSCA"/>
    <dbReference type="OrthoDB" id="3347613at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="883" mass="93921" checksum="5C315FBBE315FF74" modified="2008-01-15" version="1">MATVTMLSSPANISPVVSEATISTALSPHDATSSRVASEVLLVCLIHDSPQLRLALDDVFSHTLEPLLRSMSKLYRTSNFLVGGVVYRSMDADALAQPLRSLDAVTCVPFLTIRHFLSRVQETLRDTSIYDMAQLDDSPRQSSLVDALAAAMDLVDAREKPSITVPFARSAVRGKDPVILARHIMQIIALDSNAAATPIGQSVPQQLPVSPANLRPLMHRQASLDACTFPELVQELNKRRFNIGTVIYSSHKDETGLQTRAALAQTAHDTLCLPRASDEQVSPSDLLDSPKKLPSSVSVLLTGSDVARLLRKRPRLDLAADSPNKRARQPPTPTTPTFKLDQASLNRIMLIQQQQATMLKNLARYVATNVKPNGTVHVPPQYYEKIRQRIVGQQMALKQQAERLRVGKVPDLNSILQALSNIDAEAKEAGVKLGGPSNVRPTSTSDKMPNMGAAYLPPATAAAAAGNVTPSPTAQMAVPAAMASRPQMPSSDESSRPQLAWQGIIKWSTSPQMDPLFTLVTATCGGMYVKQQLALPWPNVMNIDGFVPIDSAQLQQHISAHRLPCALLTLRAFPQNLIIKGSEHNATNYQMLTTMLEQSRRAAFIQHGHAGCGILIVALTGSRLPPTQAGLAPRLMAVVFSSPVPFPQLSASTAPTASNTRGMIPLPATANSMPNAASVANATVPSTTSTTAGGAAGISPMAGMGPATMPPSIQPTAALTNPAAMNHSMLNMAQVFQPQTMMPSTMRTPMNGFIPNLGQTTTNNQPMQNHPMASGFPSGMNADIPSSLASSMTPGIPSSMVPGMPSGMPAGLTSNMSSVMPSPMPSSISSGMPSGMPASNMSHTSMMQPMMPNMTQPSVYPSTNQTTDLFSANALSSLGLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1Z6</accession>
    <name>A8Q1Z6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730864.1">
        <property type="nucleotide sequence ID" value="XM_001730812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1Z6"/>
    <dbReference type="FunCoup" id="A8Q1Z6">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1Z6"/>
    <dbReference type="GeneID" id="5855171"/>
    <dbReference type="KEGG" id="mgl:MGL_1863"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1863"/>
    <dbReference type="InParanoid" id="A8Q1Z6"/>
    <dbReference type="OMA" id="FMVDILN"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="552"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="621" mass="69226" checksum="6A0A091546368134" modified="2008-01-15" version="1">MDPFTGQMASSSKLSASSTKAPTKLELMMREHGDTSARESARKPTRALSMAEQQEEDEIAWLEHQLYGRKRKHHIEGDDVDDLLDDLDQFHPGMYDEDEGDHTDLAGLDSDANVNEDSEAENEEEITGDKEEQEDDEKVEDAEEEEMESEDFRADDEQVKSHMDERPENVQATSSQAGTTPKYVPPALRHQVNKSESLSVEQQKLRRHVNGQLNRLAEGNLDTIVSELEGLYRIFARSDVTSTITELCLDTIAARTNLSESIVVLYAALITSLHRLVGAEFGANVLQSCVSRFLTSYSQMMARSNSTEQGDESMSAWSRECANLIMLLCHLFNLKMLSAIILYDMVRLLLGQSFLHMVSGVDEQKPITEVDIELLLRIVQSSGQQLRHADGESLKAIVELTQQCMRDAPASAATVAQSSRARFMLESLAHLRQKGRHLGRESSATAESLQRLSKYVSSLERKRTVRAHSALQVGLQDLQDAEKRGRWWLVGAAWTGKDNSEPAPDAVAGVPISSTAAAAAAPKSQGADLDASDDESTIDLTRLARTQGMNTDARRMVFSTLMSSLDYMDAAHNLMQLKLNDVQRREVIRVLVHCLSNVRMRVSRPIHSFFFCSVHVLTLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q235</accession>
    <name>A8Q235_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730881.1">
        <property type="nucleotide sequence ID" value="XM_001730829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q235"/>
    <dbReference type="FunCoup" id="A8Q235">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q235"/>
    <dbReference type="GeneID" id="5855188"/>
    <dbReference type="KEGG" id="mgl:MGL_1880"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1880"/>
    <dbReference type="InParanoid" id="A8Q235"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="259" mass="29452" checksum="AF6385FA7AF872DD" modified="2008-01-15" version="1">MSGVPSFSERKQPGIVCLFDVDGTLTPARQQVSDEMLKVLKALREQVAIGFVGGSDLSKIREQLQLPGHEDILQQFDYGFAENGLTAYRLGAQLPSQSFINWLGEDKYKKFVKFVLSYISQLDIPVMRGTFIEFRKGMVNVSPIGRNASVEERHEFEKYDKEHKIRQTFVEALKKEFPDYGLCYSIGGQISFDVFPAGWDKTFALTHVSPDSWKEIHFFGDKTFEGGNDHEIFTHKDVNGHSVTSPEDTISQLRNLFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2B7</accession>
    <name>A8Q2B7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730732.1">
        <property type="nucleotide sequence ID" value="XM_001730680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2B7"/>
    <dbReference type="STRING" id="425265.A8Q2B7"/>
    <dbReference type="GeneID" id="5855038"/>
    <dbReference type="KEGG" id="mgl:MGL_2186"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2186"/>
    <dbReference type="InParanoid" id="A8Q2B7"/>
    <dbReference type="OMA" id="DGFYGLW"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="168"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="298"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="341" mass="37565" checksum="6A083F889A882698" modified="2008-01-15" version="1">MQAHSLQATHYERARARVNVNSAPLTCHGHTRPVVHLEYSDKQDDGTFLLLSSCKDGSPMLRDWVGDWVGTFLGHKGAVWSAKLNGGDAARAVTGSADFSAKVWDTYTGECLHTFTHNHIVRSVAVDSAATKLVTGGHERKLRLFDLNKPASNADDAQLFRARFDANTTTHEGQIRSVVLGRGTSHEHTLVTASGDKLIQWWDMRSMEPVYDMVLDDPFVSMERCAGSFGEYVTLTSGHNAMFLDLGTHEVIRKHTLDVTPSSVYLHPTTAGMFVAGCTTDEWVRVYDYETGKELDLSKGHHGPVHCVSYTPDGEVAASGSEDGTIRLWQTTPGKKYGLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q308</accession>
    <name>A8Q308_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730489.1">
        <property type="nucleotide sequence ID" value="XM_001730437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q308"/>
    <dbReference type="FunCoup" id="A8Q308">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q308"/>
    <dbReference type="GeneID" id="5854796"/>
    <dbReference type="KEGG" id="mgl:MGL_2285"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2285"/>
    <dbReference type="InParanoid" id="A8Q308"/>
    <dbReference type="OMA" id="QMGFERW"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="193"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="508"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="439"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="784"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="823" mass="89414" checksum="6223B4A8B8E2AE65" modified="2008-01-15" version="1">MEGDDGLLLNLDAAPPPSTQKNKNKSRNGSSKKRARVQESSAEDAATTKRTRGLSGAGTSAGARRQPSPTISIPKESTLSEEDRAAIIKARAMSLGSSSKTTSSHDTAPRSKGGSHGYVSSLFARDEAGASEPAGLPETPRSAPSNAPSSNASSFEALGLDEILATHLRERMGIDGKPTDIQRLAIPPLIAEPPSPTSQRDVLIQAQTGSGKTLTYLLPIVQSLLPFSEESYIDRSIGTLAIILAPTRELARQIYQVLERLLTMSLTSQHEAADGTLLRRRARWIVPNLLTGGSTKNHEKQRIRKGSPIIVSTPGRLLDHLQNTSSLDVGKCRWLVLDEADRLLEMGFEEQLSGIVKALDGRRRLSVSTAREALLNNGVIEPHAPDSQVTDSLGVAWWAWRRRVVLCSATLDERVQVFSGTTLHQPLLIRAGMHQAVEPAPGTRHKDASGPTSDSAQSVGNRTAEDHEPASLDAPVDFNGPTFSAPAQLAQHAVIVPPKLRLVTLLALLRQSLPRASEAAHPARVMVFLTCTDTVDFHWHAIGGARMGQLPTKDSDTSRPLPSSQDMPLAQKSDLLPGVPIYRLHGSMTQKERIASLRAFHTLEDGTDAAPAKRGGVLLCTSVASRGLDLPHVSCVIQMDVPTEGGVEEYVHRVGRTARVGREGTSWLMLMPHERPWLDVLTQRMVVGEPPRRASVPVVGYDTVLYEGFGGAAREYESRATDVQMALERWVLADPSHASLARTAFLAHIRAYATHPASEKAIFHVNQLHLGHVAKAFALREAPQTVQRTAKKEHERQTQPKAPEKDTEIRRQRMLANLPTESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q399</accession>
    <name>A8Q399_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2343</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730547.1">
        <property type="nucleotide sequence ID" value="XM_001730495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q399"/>
    <dbReference type="FunCoup" id="A8Q399">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q399"/>
    <dbReference type="GeneID" id="5854854"/>
    <dbReference type="KEGG" id="mgl:MGL_2343"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2343"/>
    <dbReference type="InParanoid" id="A8Q399"/>
    <dbReference type="OMA" id="DWEWAVL"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="653"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="764" mass="84473" checksum="FDC638EF580D5FF5" modified="2008-01-15" version="1">MSARAYSSSSRVLWSGTPSAGGAVGGGTVPESICDAPSHERIAQWREQHIQALQNEVLASRKGYLDARSGIVKHRRHVREDLASGTDVPLRSVLRYLSQEELQDALVYLGLLVAIMVRCIVALGDWSGRGMPPMHGDFEAQRHWLELTWHLPTDEWYLYDLPYWGLDYPPFTAWVSWLCAWVAMWFPALRDGLELDTSRGSEAPAVVLYMRLSVLVLDVLIYLPSVAWFISRRYESRSKRVRQIALLSVWLQPMLILVDHGHFQYNSVMLGLSAMSFALLQSKLPHVHASIRGPAVATAALQRLVLDTLSRHVSLRYLAAAVLFSLSLCFKQMALYYAPAIFAIMFGRCVGLLLSHQWLRGMALFAGLACVTTATFASVFAPWLRSWTDLAQVIHRIFPLARGLFEDKVANVWCALSVLPVGAKWKLQHMFHVSTLAKLSLVTVLFAILPSCVLLFLASIESVYRESIMDDAQAEQVVAKVRRHAGSVASGKSYSRLASSMRDDGGCARSLAASVHDSSRGSDRHSVASGSLLAGSTSTLMRGADGHSRPSASITPTMTAIRPTSHRSSVTPSPAAELFPYTLVSTSLAFFLFGFQTHEKSILLPLLPLTMLMTVKGDRTGAGAVAADWEWAVLTNNVGMFSLWPLLLRDGQGLAWCILLLVWNALIGYRPWEALHTTRATFVAWLSAAAHFGMLGLLLLQGFVACAPRIAWIDGLLLRYPDLFPVLNVLLCMPVFMMVWLWSLKKHLEMTLASGVLAITKTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3H3</accession>
    <name>A8Q3H3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730605.1">
        <property type="nucleotide sequence ID" value="XM_001730553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3H3"/>
    <dbReference type="STRING" id="425265.A8Q3H3"/>
    <dbReference type="GeneID" id="5854912"/>
    <dbReference type="KEGG" id="mgl:MGL_2401"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2401"/>
    <dbReference type="InParanoid" id="A8Q3H3"/>
    <dbReference type="OMA" id="VWSEQLA"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="338" mass="38245" checksum="14699A440FA56860" modified="2008-01-15" version="1">MTLHGWDPLRILAQMTALQCIHYILLAAFVPPFLSIFTEPAALRFEGGPAQVGMIMDWREVASKPTWDWHTVMHLVNLYKGWSKTGGESGPAWTPSEQVALSNWTAGAVWLHVPDHRGGLQPYVLPPTSFQWNDSSPSLANDLSTESLLTSMAEEPLIPAARSLRSPTAFASSPTSLPSSIWPSPRWLAKDASRPTNTSGTLLQQERQLEMWEYRRTHDARRGWAISAAWMLTVFFDVQVLYYLVRKPTHVLDFVCTMHFVHFILTTSFAGALPHSVYWWVLMMVHASLCIVFAERIAIQREMRMGFTDHTVLDSSQLDEDTYELLPSRSRGAGRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3H4</accession>
    <name>A8Q3H4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2402</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730606.1">
        <property type="nucleotide sequence ID" value="XM_001730554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3H4"/>
    <dbReference type="FunCoup" id="A8Q3H4">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3H4"/>
    <dbReference type="GeneID" id="5854913"/>
    <dbReference type="KEGG" id="mgl:MGL_2402"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2402"/>
    <dbReference type="InParanoid" id="A8Q3H4"/>
    <dbReference type="OMA" id="GALFIWC"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="438" mass="48674" checksum="4C45A04F181B7FC0" modified="2008-01-15" version="1">MRAWTRILAASALWRIVCVCTLLVCTHLQTAFDTSAELVRLTLPQGAWDSAWDTWAVPFVRWDTVYFVALAHPERGYVYENTLAFQPGIVFVLRRLGSIPALWGDTRWSATCAVVGGAFLANVATIVAPVLLYMLTRAQTHSRALAERAALLAVFAPASATALTAPTPEPFYSVLVLSGLCVLQRPCPLPRWCAALFFCLATCFRANGILLGAFLVWHAIHRPWIEQRQRTCITVCADVVSAAAGMIFISIPFFLHQRWAYERLCPGRPWCDMEPIPLVYSFVQAHYWDVGFFRYWTLAQVPNFVLAFPVLTLGAYGCWLATPCARRVVEQTLIPWRGSGLASDPAKRVSTTIRSRPALRCELVYVYHTAVVLCILLFASHVQIALRMATPGGMPMVWWAAAMLCERGGPAWTKGVVLYLLCYSGVACVLYAGFYPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3L4</accession>
    <name>A8Q3L4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_2439</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="16">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730643.1">
        <property type="nucleotide sequence ID" value="XM_001730591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3L4"/>
    <dbReference type="FunCoup" id="A8Q3L4">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3L4"/>
    <dbReference type="GeneID" id="5854950"/>
    <dbReference type="KEGG" id="mgl:MGL_2439"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2439"/>
    <dbReference type="InParanoid" id="A8Q3L4"/>
    <dbReference type="OMA" id="FVETDGH"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP43429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="335" mass="36777" checksum="507779BF4CBCB7B5" modified="2008-01-15" version="1">MWSCTLPQDSSRAALDPCSKDASPGYRADFVSAMAGTDAGLRQRVRVHSDRKEVLGDLRDDAEIQLKRFIETNGHFSLVRNFHLADAFTLMNGFCGAQSLYMSGRFLATSNPRYMWYALWFPFFGAIFDFLDGKIARWRQSSSMLGQELDSLADLVSFGVAPSVAVFAMGLREPLDTLILTVFVCAGIARLARFNISAANIPKDSHGKTRYFEGLPIPSSLALVGVLALCLLLGRFDVADGAWSPSMVKESLPFTGTWHGWIPGNGLPLGTCSLDFSHALYSLLVTGGVLPQYVLPTTLAGWANEFGVISIHTFSFVWLVWSMAMVSKTLRVPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3L7</accession>
    <name>A8Q3L7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730646.1">
        <property type="nucleotide sequence ID" value="XM_001730594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3L7"/>
    <dbReference type="FunCoup" id="A8Q3L7">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3L7"/>
    <dbReference type="GeneID" id="5854953"/>
    <dbReference type="KEGG" id="mgl:MGL_2442"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2442"/>
    <dbReference type="InParanoid" id="A8Q3L7"/>
    <dbReference type="OMA" id="YNEDWMR"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000011">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="98"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="533" mass="58820" checksum="DFD731BC1A9F4E08" modified="2008-01-15" version="1">MISSSVARLSQLSLRRAVSRHHVYATQITIHGIRSYAVKVSRNPDFGTITSPILQQFASVLSTPQTSLISTIPSERKEWNTVEESELDSYNKDWMGKYIGRSKCVIRPKTTNEVAQIMRICYEHRLAVVPQGGNTGLVGGSVPVFDEVVLNLSSLNQIRSFDATSGTLVCDAGCILETLDDFVAKEGYMMPLDLGAKGSCHIGGNVASNAGGLRFLRYGSLHGTVLGLEVVLPNGDILPGLQTLRKDNTGLDLKQLFIGSEGSLGIITGVAIATPKRPTSVNVAMFAVESFEAVKTTYQRVRQHCAEILSAFEFIDQQSFDLVLKNTSRKPRDPFEERYPMYVLIETSGSNQEHDESKLQGLLEDLMESSIISNGVVAQDETQIKALWSLRESVPESLGHYGKVYKYDVSLPMDKMYELVHILQDRVIGSGMMPSANEPGRVKAVCGYGHFGDGNLHINVVAENYAADIENVIEPYIYEKVQEMSGSISAEHGLGVMKPDKIGYTKDPLSVHYMKQIKRLFDPQDIMNPYKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3P6</accession>
    <name>A8Q3P6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative tyrosine-protein phosphatase OCA1</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730669.1">
        <property type="nucleotide sequence ID" value="XM_001730617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3P6"/>
    <dbReference type="STRING" id="425265.A8Q3P6"/>
    <dbReference type="GeneID" id="5854976"/>
    <dbReference type="KEGG" id="mgl:MGL_2465"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2465"/>
    <dbReference type="InParanoid" id="A8Q3P6"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF8">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="61" mass="6923" checksum="ACC0F152D4B70CAE" modified="2008-01-15" version="1">MLVPPPNFGMVEESLYRSGQPDQLNFPFLEKLGLKSVIWLAPEEPEVGFISVMTRTLRCIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3Y0</accession>
    <name>A8Q3Y0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">DNA topoisomerase</fullName>
            <ecNumber evidence="4 10">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2478</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="4 10"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730096.1">
        <property type="nucleotide sequence ID" value="XM_001730044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3Y0"/>
    <dbReference type="FunCoup" id="A8Q3Y0">
        <property type="interactions" value="662"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3Y0"/>
    <dbReference type="GeneID" id="5854398"/>
    <dbReference type="KEGG" id="mgl:MGL_2478"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2478"/>
    <dbReference type="InParanoid" id="A8Q3Y0"/>
    <dbReference type="OMA" id="VIHNVYS"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="13">
        <location>
            <begin position="75"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="694" mass="79197" checksum="DEF363A06DB2BEAA" modified="2008-01-15" version="1">MQESESIARNLTIEARSTDMLIIWTDCDREGEAIGFEIAQHCQKAQRRLIVKRARFSAVIADQIHHACMNLVDLDLHAVDAVDARQEVDLRAGAAFTRLQTMRLGPLLKLDSMLLSYGPCQFPTLGFVVDHYKRVETFVPEEFWSIDLRHAVSQQGQDRRTNVEFLWDRNHLFDKRIVHILHKRCKDAEEAEVKQVVRRTTWKRKPTPLTTVELQKNLSRLSGMAPKRILDVAESLYQRGLLSYPRTETNQYDKDFDFVSLLDKQRSDCIWGAHATEIFASATGNGSDSLHSLQYERPRDGQKNDKAHPPIHPTAHANDLKADEKQVYDYVTRRFLASCTTDAMGEETKIFIEMGGESFHTSGLLVKTLGFLTIFPYEKWTSKFVPEYQERQRFRPSSISVKSGSTSPPNLLTEADLVHLMDKHGIGTDATIAEHIKKVIDRQYVVITKQGKTKYLVPSTLGMGLVEGYERLETSLQLCKPKLRHDTETQLGLIATAQRTKQETVSENLTEYKRIYDIVERDFEQIRDAVCTYFRTLPQDEVQGPRWQHARREQRQAEAYCASPFPNESAQTESSTPTCHCSAACTTCTEHRSGREYWACGNRDLRGHDCGFFRWCAMTPTSPHTNEGQASRILQEATKRSADREPRAKRAKTNGQHTMCNCDLIAKCCRAQKGPNAGRLFYTCPKESKRASPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4F9</accession>
    <name>A8Q4F9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rgp1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730154.1">
        <property type="nucleotide sequence ID" value="XM_001730102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4F9"/>
    <dbReference type="FunCoup" id="A8Q4F9">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4F9"/>
    <dbReference type="GeneID" id="5854461"/>
    <dbReference type="KEGG" id="mgl:MGL_2536"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2536"/>
    <dbReference type="InParanoid" id="A8Q4F9"/>
    <dbReference type="OMA" id="HHENTLD"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="66608" checksum="D28879D82B957CD4" modified="2008-01-15" version="1">MSHPHARQKSVVAYQVEDLSQAFGLLQNHDHADADAAAESTTVSGAAPHALTDFQPSPHPDMYVSHNEAMDAALRDSVVTWAGDSLTEHEVKSPLFPERDTLPIGHEKLLWTFAQFGGTMELEHGLVRATDFDRLRMRLARGELPSVPSSPASAEGTPRTLGGGEFGYDAEYEAGSIEYDKGLVTADLREKHAPAIATIAALLFRPASMLRSPQQHQQPSPSLRHSRSGSTLSDIQTRTLMSRTLPTYSTPPTMLGIDMQLAPGESRSFTFKLQLPMDLPPSFHGHSVHFDYYLTVGTNRADTRSGSAQQSRLLHIPIRIYNHVAPSTGLHTCFDLLNPIVTPQLDASVAAVQETSAAGGASAAAGKSAQAYEKERAETAQWIARLWEGAQPVNERTDAPTVPSCMDAVHDLTQRAGKVSYDIAKNGHVAAVLTLARAKYRLGDDVQAIVRMNMPETSVRIVRLAATLESHEEIDATMALLPAGRVQKATTQVYAVHHENTLDTRQTSVLLTIPSGATPEFSTSGIRHRWSLRISLLTETADNGTHQVPPPPHLQPESEGYAAYHTSFHGTQSLCGRIGTLTTRLEIVECSVPVVVLPNRSRRKTVPVELYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4P4</accession>
    <name>A8Q4P4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730213.1">
        <property type="nucleotide sequence ID" value="XM_001730161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4P4"/>
    <dbReference type="FunCoup" id="A8Q4P4">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4P4"/>
    <dbReference type="GeneID" id="5854518"/>
    <dbReference type="KEGG" id="mgl:MGL_2595"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2595"/>
    <dbReference type="InParanoid" id="A8Q4P4"/>
    <dbReference type="OMA" id="ISWGIVH"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="548"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="716"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="730"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="829" mass="91078" checksum="264619AD09B0AAB8" modified="2008-01-15" version="1">MAPPKASQTLWGRTKALAKYIVGYDNTDANRLGVPMVGVQDYVREHCQHPGTALLNYLDSLFPMRRWILSYNLSWLYGDLIAGITVGLVLVPQSMSYANVAGLQPQFGLYSSFIGVVIYALFATSKDVTIGPVAVMSLQTNTVIQKIREELPDHHYPPEVIASALAFLCGIITLGVGLLRLGWLVEFIPAPAVSGFMTGSALTILVGQLPGLLGVKNVNGQDPMYKIVINFFKQLPTAGMDAAFGVPALVFLYLVRSTCNYIARRYPKYARIAFFASVMRSALVIIVLTVASRIWVGTYDQKQDYPIKLILDVPRGFQHMGQPELPTPVLSKIGPNLPASVILLLLEHIAISKSFGRLNNYKINPNQELVAIGVTNLVGPCFGGYAATGSFSRSAIKSKSGVRSPLAGWVTAIVVLIAIYALSGVFYWIPKASLSAVIIHAVSDLVAPPSLLYKFWLMNPLELFIWIASVVVTIFTSVDYGVYTAVAASVALLLIRIARPRGHWLGVVRVEHHDHTVAGGAQQRNVFMPMDVQDGLRDPSVHVEPPPPGVFVYRVEESFTYPNASHMAELITDKIKACTRPGFSQAVKPGQRPWNDPGPPNAALIRAWRACTFFYHRHKDAPSLEQELEEEMRSKESDPRPLLHALILDFGSVSNVDSTSVQVLVDLRNALERYRAGPVQFHFAHILSPWIRRALLAGGFGTGRIHRHVTEIASVVEQGDARAVGQHSPTPEDPKPHDETDSKTTDSVHEQDVPRDLESQVGSMAADMDKLDFEIRNLDAKYAEDLRHESISSPPGISVPIMWNNELTPYFHLDLAAAMSAATDNMSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q506</accession>
    <name>A8Q506_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_2689</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730307.1">
        <property type="nucleotide sequence ID" value="XM_001730255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q506"/>
    <dbReference type="FunCoup" id="A8Q506">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q506"/>
    <dbReference type="GeneID" id="5854612"/>
    <dbReference type="KEGG" id="mgl:MGL_2689"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2689"/>
    <dbReference type="InParanoid" id="A8Q506"/>
    <dbReference type="OMA" id="FTEWELY"/>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP43093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="398" mass="45876" checksum="6A9BFD52717253C2" modified="2008-01-15" version="1">MSKRTAEEAAHRRHILHILQSMNLPMVQYAFAYGSGVFSQAPVSQKVGNTPPMIDMVIAVKDPIHWHAANMLRNKSHYPWWTRWCGLWAIKAAQRMGAGLWYVPYVNVQDEIVKYGIVSVEDMCKDLLYWNTLYVGGRMHKPIACLFDATNDRVPNAQQANLTSALRVALLMLPTSFTEMDLYRMLASLSYMGDFRMKVPGGENQNKVNNIVQHQLPWFRIMYSSLLSRLHFVHVVRGDDVCFSMRQDKRPATMALVAILLPQNVRLRLIQHYQREYHLHPVFEKCKNMSPEELIPAALANIRKLRDEPDIIAKLQTDDDCEEAAEWPISTRFWLAVAHQSTFQDVLRQQIVDIVANPARVQSLKGLYTAGIGRSVRYLWSKMRKYQKGRTFTSINSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q522</accession>
    <name>A8Q522_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2702</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730320.1">
        <property type="nucleotide sequence ID" value="XM_001730268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q522"/>
    <dbReference type="FunCoup" id="A8Q522">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q522"/>
    <dbReference type="GeneID" id="5854625"/>
    <dbReference type="KEGG" id="mgl:MGL_2702"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2702"/>
    <dbReference type="InParanoid" id="A8Q522"/>
    <dbReference type="OMA" id="EMFIRQN"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="177"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="467" mass="52169" checksum="AFDBE33E7B21AC43" modified="2008-01-15" version="1">MKTVPLVYTPTVGDACLNFSRMFRRPEGLTLSIDDKGAIEKCIENWPRPADAPRVAVITDGSRILGLGDLGWNGMGIAIGKLSLYVAGAGVHPQSVMPIAVDVGTDNEELLNDPMYLGLRRRRPSTEELVEFVDEIMEKLHAHYPSLIIQFEDWSSEHAFMFLDRYKDKYPMFNDDIQGTGAVILAGLISATRLVEKETKKSSDHRILMVGAGSASVGVAKQLMSFFTLNGMSEARLRIWTTDSKGLVTMNRGDKLPDYKQYFARRDNGDMQLKELSDIIDYVKPTVLLGLSTIHGLFDEKILRKMADLNERPIIFPLSNPTSKSECTFEEALTHTDGRCVFAAGSPFGTVNFHGKQRFADQGNNFYIFPGLGLAGALVKAKHMDHKVITEAAVALADSMTKDEVDEGRLYPKLGRVREISQYVAFRCIKVLNKDGLCRDDGITASMSDDELFRYVGDHMWEPHYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q583</accession>
    <name>A8Q583_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730366.1">
        <property type="nucleotide sequence ID" value="XM_001730314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q583"/>
    <dbReference type="STRING" id="425265.A8Q583"/>
    <dbReference type="GeneID" id="5854671"/>
    <dbReference type="KEGG" id="mgl:MGL_2748"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2748"/>
    <dbReference type="InParanoid" id="A8Q583"/>
    <dbReference type="OMA" id="ATEYICY"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="308"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1080" mass="117437" checksum="B80B14472A9FBC98" modified="2008-01-15" version="1">MDAWPESEPVGVSTTPDNMPEWKDLDSMLGSPKPWSMVDMPDLFLTNLIHDVDHTFTDDSLTDFSSTVATSGSETESSPGAFQEFMMRHSSPESLSHSPPPLVPGITSPTQFTIPLPDTERLDLAPHVAETNEPLTASFGLDQVPVTSYSPAYMEMTLGISPASVQHGVEPVKPVASTETVPPVASMSSMALTSSKASDHSNTPVPPAMPAVATKPDIQASKAVSTPSATSEETILAPLCMQPGSNHNAMMALSRLRSAVHESEKQIQAKKAPCAKMPSVSAPSHEMSIASATTTYSESDAQHPGQHARKNAHNAIERRYRSNINDRIAGLRDVVPALRETRPRNGRRKRRRGKTEDIELVDGVRAATKLSKATILTKATEYICYLKSREVQLSREVAGLHMLLRSFEGGDELLTQWSAEMERLHNQYPPIEAVYSGVETPPPTSPNASATGVTATSLSSSSSSAFPRGSLDVEVEDDESADESDEADDTESLSSGSGGDPVRATKVARYMFGAFVGLSFFGRSDWGDLRNTDADLALLNTTALSAPVSTSSLPQAHVMGVGHQLWKRSLSMDHKPRPYDDVPTSDLLWEVARGCVLVTLIVAVVCSMGTHARRWALKRGYLTASRLQDTSTLSDLLCTPLEQVRSPPMPLTQAKVTYERLGDRLCVPSTRLGLLMHMTWTCTCWLSAATVPGAAGWIRSLTDPTVALIKKRAFIRRAEFELALGRSVQPDWFVRLHTLIMLHFYASVFGAELDEKLVLALVYLDAAEQTHLPYMAQRGAQVWHSTGARLVDASSSSDPGQEQNRRMLSELFSVPICHVNAYARTASCGNESSENTRRDEDSECGHVSVSPLANMVDALRHEALLSFWTTMISSMMRASDSVVSAPSAHSCSHPAVLDIVRDTASLASVQQQLASLTRDRACTSSMTVEQILVAHGMLDLAAGRLARAHAYVRMLGSKPISLSARQFIALWADAPFVTSRTPVGPVDMLASVAIGWFAMQRMYATHNDANATENAKAWHDRRRKSASSLHALASQCLWIFVSPDKKDNSDGTYVRDLLPPNQVPCLAQALDSLMDNLLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q592</accession>
    <name>A8Q592_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730373.1">
        <property type="nucleotide sequence ID" value="XM_001730321.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q592"/>
    <dbReference type="GeneID" id="5854678"/>
    <dbReference type="KEGG" id="mgl:MGL_2755"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2755"/>
    <dbReference type="InParanoid" id="A8Q592"/>
    <dbReference type="OMA" id="IPLRYEC"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase Sen1 N-terminal" evidence="7">
        <location>
            <begin position="104"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="8">
        <location>
            <begin position="1151"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="9">
        <location>
            <begin position="1438"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="708"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1300"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1663"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="853"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1304"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1682"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1708"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1725"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1742"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1780"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1854"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1890"/>
            <end position="1900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1900" mass="208317" checksum="7D4892B2C4D77871" modified="2008-01-15" version="1">MVWLEAQHVLEPGQSAVEKAEKYVADARMEWPLARMMLAELSHIPHTERASSSTSTTESKRPSSPFDELVAVIKASHGHDANAWKAILPTYDGSATQWQVLAPLAMDCIPDSDTPLEPLLDVLSVVCLHTLSLSIWGRTGRSPMPVLIHVLDHPALDSVRPACLFVFLVRFFDVIYAYSRSVYAEALKLATHFLLEKRQQTHERDTVRSTALTLGALLIEDRISKALHASLTSSSTEDRLQGDACVSLVLDLYALVLVQGGLTTPRLLRPVGLALVHDAVKTMNACLYLSSITGVAASIRKTYAHDHDPSTANERLFMQWEADIDAVCVPTVSQRLWKHISLVLSSEEANDVPQVLCAYFLYALSIVAPGYPAPILEVHTPKPLAEMPVPSSSAPASQAYDRLCAGISALVVQLRQGMSCIANAFTVALAHARDTFASMPRVCVSVLPLLGASASTEVSQGAHVIFRALADDSYTRFESLHMLWMDAREAALEGGRSFVVLFVLAARHVAWALPLARASVSMLDDMLHVLCDRNMGVLLPYIPWGSGMGREADVLFVWTGISECIATMFERIPDWSRTADRQEMLQWIAQVPMLASYMVQSADLACRSNELHSHTDDVLGTLAMPLDCAINWLRLNHEEILQQLSDYIRRAVHLFSTRHLVLPAQVRKHAVDFLAQQLGVTNVQERRTLLSTAQMELLLDEFLALPRSEPKTDSKADPKPKTKPRLLQQTLSFTTVPPGQKERTEPKKKPIVVDLTRDSPRTAAPKLKGVSSSTASSTRASKLHSTGKLAQLRNEFQLTRSVARKPHAPVRAWEPDEPRAPLATSSVTGTITTMPRAQIRRPTQQPSGHDGSDDSDTNDSDSDADSSSSDGHGARAERGKPSAKGGLAALASPHRAKPTVVRRTVMPMMDPALQEAMRKADDEQRRRRLSTAPSMMPMHECILSWSMSSNEPLPPTKLDGTAFSTSSPGSWHATASSYTEHFGTLLTLEAWAQFQQACDDVKYATSVDVQYLRQSRVDNFVQLEFAARSTMPAGVYFNETDIVYLELPSRALKLIANVYFSRKQATSQPGSSGLELGIRCLYAQAQNAMPWIQEPGWRIVKLFSLTTLRREYAALCSVPDLAMVQDVLHARVAPLPDVSVADQTKAMRMYELNEPQARAVVATMRTPGFSLIQGPPGTGKTKTIRALVASFLSRRAGTSVGPKKAAAPARDGPSARMLLCAPSNAAIDELVSRIKDGVDIDGKRVVPRLVRLGRDEAVNPAVRDVTLDALAEHAGSKDTAASRAAEELQRVERAWRDKRAELEQSASAPTSSTSRERTRALQAELNELTDKRFELREQVSSLQSRSKMGSMRPETERHMARMSILDEAEIVCATLAGAGHEMLYRYTFDTVVIDEAAQAVELSTLIPLRYECTRCILVGDPKQLPPTVLSQEAERRQYAQSLFVRMFNASPDRVHLLSIQYRMHPDISLFPSTAFYGRQLIDGPQMASKTLQPWHNTQLFGPFRFFHVDALEEPGRSHSIQNQSEAYTAMQVYEALCACAQTSLRGRVGFVSMYKAQVDLLRTLFVSQYGRAAAMDVDFSSVDGFQGQEKDIIILSCVRSNKDRVMGFLSDHRRLNVALTRARSNMIVIGNASMLGNDTIWRDMISEARSRGFVVPVRGDTFVHPQRLAPPNQGGRESSQVAAAASGPPTPSSSAAVPKKTPAPAPSRDAKLRPPLHRKLDSSERASSPTTPSAVRTPKTKTIAAPTSTYPSTSTFAPKASAPAQAPAPSPILSTHKRPVPPQPVQPIPPPVHAKASGQRPPKRKSTEPPPILKAPPRVVPSAALLAPTKTQQPATQRTKKPGKWAAIVERNQASSSSAKPAPSAQIPPVVKADRPPREQGGGPSWLRSARPHSLPRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5P6</accession>
    <name>A8Q5P6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729816.1">
        <property type="nucleotide sequence ID" value="XM_001729764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5P6"/>
    <dbReference type="STRING" id="425265.A8Q5P6"/>
    <dbReference type="GeneID" id="5854123"/>
    <dbReference type="KEGG" id="mgl:MGL_2802"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2802"/>
    <dbReference type="InParanoid" id="A8Q5P6"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="98" mass="10787" checksum="4FF3155D602E46F6" modified="2008-01-15" version="1">MSSIAPVDDQHILIGSSELRAGFSTSDSDDPAYTCENIVSRFRDRKRGANVVLCGNNCYVDAQARANIKSPFDGDVVCGFDTMTTVDLVRTYVRELTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q628</accession>
    <name>A8Q628_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729859.1">
        <property type="nucleotide sequence ID" value="XM_001729807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q628"/>
    <dbReference type="FunCoup" id="A8Q628">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q628"/>
    <dbReference type="GeneID" id="5854166"/>
    <dbReference type="KEGG" id="mgl:MGL_2845"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2845"/>
    <dbReference type="InParanoid" id="A8Q628"/>
    <dbReference type="OMA" id="TMRQPGL"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="96"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="186" mass="20970" checksum="1ED0FEC298E4021E" modified="2008-01-15" version="1">MFFLKTLDHRTELHPSFFGPSMIEFLNRKLRDDVEGTCSGVYVRTYKSMRLMLILESQGYIIKVVSVLDVGQGKVMPGTGLAEFRSRYQAIVLKPFNGEVVDAKITNVNKMGFFAEVGPLSIFVSSHLLPIDYKFHPDSNPPEFTSPTDSLVKGRRVRVRIVGTRVDANEIFAIGTMKEDYLGPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q670</accession>
    <name>A8Q670_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2866</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729880.1">
        <property type="nucleotide sequence ID" value="XM_001729828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q670"/>
    <dbReference type="FunCoup" id="A8Q670">
        <property type="interactions" value="601"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q670"/>
    <dbReference type="GeneID" id="5854187"/>
    <dbReference type="KEGG" id="mgl:MGL_2866"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2866"/>
    <dbReference type="InParanoid" id="A8Q670"/>
    <dbReference type="OMA" id="KICHNCG"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="607"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="700" mass="77893" checksum="A1BCB2B34AA80F08" modified="2008-01-15" version="1">MSGGTEEYGEFLHLDRRFTDFNAIRQEIENETFRVAGQNKGISKQPIHLKIFSPHVINLTLVDLPGLTKIPVGDQPSDIERQIRSLVTDYISKPNCIIIAVSPANVDLANSDSLKLARSVDPQGRRTIGVLTKLDLMDQGTHALEILSGRMYPLRLGFVGVVNRSQHDINNGVPLAEARRAEEEFFRTHLAYRSIAHKCGTKYLAKTLNQVLMAHIRDRLPDMKARLNTLMGQAQQELASFGDVSFMGDQHRGTLILKYMTQFARDFVASIEGTSFDISTKELCGGARVYCIFQDVFGQALNSINPTQNLTVQDIRTAIRNSSGPRPTLFVPEAAFELLIKPQIKLLLPPSLRCVELVYEELMKICHNCTSSELQRFPRLHAQLIEVVSDLLRERLGPASEYVQSLIEIQTSYINTNHPAFVQDSANIATRMRDDKQRKMISESSRPDTSLDSDLGAPAIDDDENKQGQALVVNGANSKRGSEHARQGHSLKETMRPPMSDSSAEAPSSAGSLASSNHTGPISASGQRESFLNYFFGGATMSDTSGSGSGVSMGSRSVEQKPNILTGRLGLEGDSAAFNMKSLDHHLSTESVPDDEYSLTEREAMETNLIRELITSYFNIVRQSIQDLVPKAVMHLLVNYSRDTVQNRLVVNLYKESMFEELLHEDETLTKERQRVQALLEAYREGFNVLSEITYKPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6B1</accession>
    <name>A8Q6B1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729921.1">
        <property type="nucleotide sequence ID" value="XM_001729869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6B1"/>
    <dbReference type="FunCoup" id="A8Q6B1">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6B1"/>
    <dbReference type="GeneID" id="5854228"/>
    <dbReference type="KEGG" id="mgl:MGL_2907"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2907"/>
    <dbReference type="InParanoid" id="A8Q6B1"/>
    <dbReference type="OMA" id="QCEFVYL"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="298" mass="34309" checksum="D1B8302B123CAD7C" modified="2008-01-15" version="1">MTLPEPMPTPLHGYVGFDTLTKQVESKMMRRGFQFNVMVVGQTGLGKSTMINTLFSSRLLESKGRMDPSDEIRQTTSISTGSHGTLTGIWETIIKYIKDQYSIYLRKELTAVRERHIPDTRVHVVLFFINPSGHSLRQIDIQVLKKLGDIANVIPVIAKADTLTLEERDLFKQRVRAELQNNNIRVYPFDHEDYDEEERELSSQVQAMLPFAVVGSTKVYDVDGMPVRGRQSRCGMINIEDPMHCEFVPFRNFLLRTNLHDLIDTTAHTYYESFRSKQLLALKESSAKHQQQQQQTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6C0</accession>
    <name>A8Q6C0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729930.1">
        <property type="nucleotide sequence ID" value="XM_001729878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6C0"/>
    <dbReference type="FunCoup" id="A8Q6C0">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6C0"/>
    <dbReference type="GeneID" id="5854237"/>
    <dbReference type="KEGG" id="mgl:MGL_2916"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2916"/>
    <dbReference type="InParanoid" id="A8Q6C0"/>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="232"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="317" mass="34541" checksum="75A9C95CA2DDBEFD" modified="2008-01-15" version="1">MSITAPKPAWNGLPIRVGVIGGSGLYKLDGIDIVDIVNPETPWGYPSSPISIVRTPSGTLVAFIARHGLTHSISPTHVPSTANIAALKHLGVRAILAFSAVGSLREEIAPKDFVIPSQIIDRTKGIRRASFFGEGEEQNVIAHASFGDPYDTRLSPIVEEIVREALKAHAPDVNVHANKTVICMEGPAFSTRAESVMYRQLGGDIINMSALPEAKLAREAEMSYVLIATATDYDAWRETSDVVDVTEVLQSLNANVQASNVVTKALVDKISALVSDDDSEYFSKMNGSMKNNIMTKPEHLPTHVKDRLRYLLPWYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6E0</accession>
    <name>A8Q6E0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2936</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729950.1">
        <property type="nucleotide sequence ID" value="XM_001729898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6E0"/>
    <dbReference type="FunCoup" id="A8Q6E0">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6E0"/>
    <dbReference type="GeneID" id="5854257"/>
    <dbReference type="KEGG" id="mgl:MGL_2936"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2936"/>
    <dbReference type="InParanoid" id="A8Q6E0"/>
    <dbReference type="OMA" id="IQIHKSM"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001669">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="140"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="564"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="685"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="816" mass="92082" checksum="3A41D60F0B92F625" modified="2008-01-15" version="1">MSTDVPRHFREPAVSLPMAPRRAVLQSLSTQETVPVHRHGVTAPMHKLSENGMQHEAHKYVQDRMRTAAPTMMATERGRDQLAPLDGLNNLGPAAHVQPLSPKRAPAPITKEAAAGSHTSKKPQLPTPPRVIVDPEGRQYERHAMLGQGGFARVYHVTNEIGEDKAFKVIAKSAIMQSKKNRQKILAEIMIHKSLKHVHIVGFEDVFEDSENVYFVLELCHNGNMNDIVKRRGPYLESEARYFMIQILAGIQNMHNNSIIHRDLKLGNVFLDKHMKVKIGDFGLAALLKYPEERKKTVCGTPNYIAPEILYDQGEGHSFEVDIWSVGVILYTLLVGRPPFQTSNVQKIYDRIRRNEYEIPPEANLSPESQELIRQILSQRPSERPTLHEIMNHAWFRVGTVPLTVPSSAVYQQPYIPALSEAESLRNFEQLKLEAQWLTEEQEAAAAAAEVVSSPRPDARHELNNLEAAEEDRDRLDRESQQAINPGSPISTLLKQSSGDQRALSTMELTEHYLSQALAHLDADIIEPMVCVDPMGEVVTVPLPNVMDGEGGQLRLKPDAPRLFIISWLDHSEKYGLGYALCNGTVGVHFRDSTSMVLAPRRQAFDYVYTVRQRSSDHERHDQLRRENYALPPSTATGPLDWLPRELVSKFKLLRFFESEIMERLYGADSPLTYVDEHATSHLGFVHKWYRCKQAIVFRLSNGTVQFNFYDHTKVFLSCDGLVISAIEPVDRTDGVPVLRTWTLTELVAIAHPRRSATETASLHDTAQFPTYFTTKPSERRFVRQVIKKLRYVRDVLLTTTTASSSSPASSASPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6F7</accession>
    <name>A8Q6F7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MGL_2953</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with the MLH1-PMS2 heterodimer via MLH1. Interacts with MSH3. Interacts with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'-&gt;3' exonuclease activity. Interacts with PCNA, and this interaction may both stimulate the cryptic 3'-&gt;5' exonuclease activity and suppress the 5'-&gt;3' exonuclease activity. Interacts with WRN, and this interaction stimulates both the 5'-&gt;3' exonuclease activity and cleavage of 5'-overhanging flap structures. Interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5'-overhanging flap structures. Interacts with DNA helicase ZGRF1; the interaction is increased following DNA damage induction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729967.1">
        <property type="nucleotide sequence ID" value="XM_001729915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6F7"/>
    <dbReference type="FunCoup" id="A8Q6F7">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6F7"/>
    <dbReference type="GeneID" id="5854274"/>
    <dbReference type="KEGG" id="mgl:MGL_2953"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2953"/>
    <dbReference type="InParanoid" id="A8Q6F7"/>
    <dbReference type="OMA" id="HCVEIQR"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000111">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="20">
        <location>
            <begin position="57"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="300"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="466"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="533"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00064664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP42753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="572" mass="61945" checksum="A05CFA63DD3B00F6" modified="2008-01-15" version="1">MSKRDSVSNLTYRRRQEHRTRGLQYYREKRGSAARDAFVRSIDVTPSMAYELIKILRAQGIPYVVAPYEADAQLAYLEQEGLIDAIITEDSDLLVFGCKTVLFKLDTYGHCVEIQRDRFVHAKQLAFDGWSLDDFRRMAILSGCDYLPSITGMGLKNAHKFLRKYESIERVLRVLQLEGKMHVPPAYAADFARAEFTFAHQRVWDPRGPGSLTTLAPLPCDINEDLLACIGIPPSLEEARAIAHGDLCPITRQPLSRPALGIALAPAQSVLSSHSVHAGHPGRAPQQTLHSFFRSSASAAPPRMSLAVSKDKVDRADSSTSSTTTTSSSCASLLDTASRSTPCTSPAHSVSGSGTDGEADVDEKSKGTTPPPSSPDAQSESDVVDACVSSPASSPPPPFAPLAKVAVNPMHSTPARRASPPPVTPMSTGLAWHDTSESAEHDMARRSAWFQRFKYSGTRARHVVLPKSLPSMPRTPPTPVPKPDRRLRLGKRPSPPPSAAESPTTKRMALDTPQHPDVPAEASMAMRTLPSMSTTLATPETLASRATAPVSSAGTSVGHGSMKLLQFQYRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6J1</accession>
    <name>A8Q6J1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729996.1">
        <property type="nucleotide sequence ID" value="XM_001729944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6J1"/>
    <dbReference type="GeneID" id="5854303"/>
    <dbReference type="KEGG" id="mgl:MGL_2982"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2982"/>
    <dbReference type="InParanoid" id="A8Q6J1"/>
    <dbReference type="OMA" id="WINERES"/>
    <dbReference type="OrthoDB" id="3362654at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1141" mass="125531" checksum="6E9D7F85C4CB5BC0" modified="2008-01-15" version="1">MSFASPIATQPGEPMHMDSHLGISFPWEKTGESTIVGGQANFLYVDMAESESDDESDEPGYMNGTSSCRSPDTFSAPTSRSPERHNSSTTSHQLDSPSFLAYPCTMPAEEHHQHQQESSHMFGPSCISHEPLETGERAQASIEEHIHAPSDEYAQFAQDASVNDAPEHHAVVCSDTYMGFDDFERALVQEHLEHQTLSRISKVTRLSSERPHLDTSGTNPGLSPHVADESQEQSLYDDPSPEAARPKQNADACHLRKDHGDGITDSQRQSVDDVPLFNHTDQEENPDYDHFGVQRGSRDHNNVDGGLESHHTDGEADTSTRPDGDVYGGWINERESSGTIAGDNHPEDHGMNESTSPIEYEQVPELRSMKHHMYSFQPNERISLNRERNISRQRDRPDASAARPEPTSQPSEKVDGLGISGARHESHDMPTWHRFSTQHPDTENVCDTRMDESHAKMSYRPDLSNRMHEGEASHAKGFFDETPPIRPNTQRTTRSQPRASAAERKEPVSVRQQAQGQSDTSSSLAATPQSRTKTPGHENRTLKNKASRFFKSMLSGKTKQRAPDAPAKTSAAEGSYRSPTPPLPQQHQQLPPQSPPNKARWNLRDRFRTANTRGGTQQETKEPHNKFTSSSPSQQLPSLAYQLGRATGSEQLDPLLSNFPNLASTEPPKVPKRLNRDAPSPYYSPDLSNTQQPPSPLPTRRAHAKSKSAQPQQQEFLGSNATSPLTTFLKKRPSDLMVSERTSLSHQASNGILPMRITSEEPVPVEVEIKRQESLMRSRRRSRSVGNLVTRSNGNEYLPNVQEHSVDTTHVPAMDPSAFALLDAQPGLPPVMPFTVPAPSTSAAQERQQRMSASTYASSSNVFDARSSMLSDQGASTAQTTPYGSSTSLNNLKTYNASQHLQQPYPHVHGLDQAHSQQCLDPARTYPAKLPPFPRTRGSMPFPSSSLPARLDESTSPDASVLTNPHSKELESVHESPGRRSSFGAPSVPQPPQPRSEPPPLRKEQSELEVKQTPKNVSAPTPKSTGPTPILNMSRDNDDASHTSPSSKLADIIPPLSTPPPAHSFDVTPHASRNANSISAKKEVSPSPELMASKCSTSMPPTLPNPTFDEKRLSLGLDECSWTLDLDFGVSDTAAQTNPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q752</accession>
    <name>A8Q752_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729760.1">
        <property type="nucleotide sequence ID" value="XM_001729708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q752"/>
    <dbReference type="STRING" id="425265.A8Q752"/>
    <dbReference type="GeneID" id="5854066"/>
    <dbReference type="KEGG" id="mgl:MGL_3304"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3304"/>
    <dbReference type="InParanoid" id="A8Q752"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="185" mass="21218" checksum="2F984B19330A3BD1" modified="2008-01-15" version="1">MARHQADGRWYPARITSVAGSAENPVYSILYTKHRTTDVVTASDLRPRQQHANAQAGMAGEASGLTTTATMAMASTKPKNTGALRPMTNDERERERERKRVRKEKKLEREAAKNMEHDRKQSSWQKFQAKAVKKKYGVAGDRSMFKTPDDPYAKSTYNWFCTITHTLFFFLAWNEWQSDRLEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7T1</accession>
    <name>A8Q7T1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729567.1">
        <property type="nucleotide sequence ID" value="XM_001729515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7T1"/>
    <dbReference type="FunCoup" id="A8Q7T1">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7T1"/>
    <dbReference type="GeneID" id="5853873"/>
    <dbReference type="KEGG" id="mgl:MGL_3111"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3111"/>
    <dbReference type="InParanoid" id="A8Q7T1"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="121"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="391" mass="43872" checksum="676448CC03D941AD" modified="2008-01-15" version="1">MIVMGMPSFPYKLIIPLLYMLVLSLPITSQLFLPAAPILLWLLLFYSCRFIDVSARPHIWVSVLPTLETIWYGANISDILTRFGHPFLDVLAWIPYGVVHFMAPFIVAAFIFVYAPEGSVKVFANSFGFMNLMGVIVQIAFPCAPPWYELREGLSPANYGMRGSPAGLARIDAIFGGFGYTIAFSSAPVVFGAFPSLHAATATCEALFLSYFFPVKFHLGPWRFDARILYWSYCFWLYWSTMYLMHHYLIDLVAGGCLATFSFYFFRTEEVRDAMERREALMEQAEREESGEPEEEVFSLEEAPFRHSSNNATSTHAASSANQPAQARSHGNAISEMPQEPLERDPIFTLEEGDAESPNHEPSQKNGNLSSMSSTFQGQGLTRPAVASSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7U2</accession>
    <name>A8Q7U2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729578.1">
        <property type="nucleotide sequence ID" value="XM_001729526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7U2"/>
    <dbReference type="FunCoup" id="A8Q7U2">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7U2"/>
    <dbReference type="GeneID" id="5853884"/>
    <dbReference type="KEGG" id="mgl:MGL_3122"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3122"/>
    <dbReference type="InParanoid" id="A8Q7U2"/>
    <dbReference type="OMA" id="KVNHQWK"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="153" mass="17280" checksum="328BB4724372019E" modified="2008-01-15" version="1">MFASLIRWSRTTYRGARGSGAGRSGNTDARSSKASRPTEVLAAHAGHTFKRAQRGLYDGRIVQFGNTIPKSRHKTSRKWTPNIQRTTLWSETLQEYVTTRVATSAMRSIEKHGGLDQYLARTKESHLGEFGRTLRMRVARALRDKRMENAQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7V3</accession>
    <name>A8Q7V3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729589.1">
        <property type="nucleotide sequence ID" value="XM_001729537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7V3"/>
    <dbReference type="GeneID" id="5853895"/>
    <dbReference type="KEGG" id="mgl:MGL_3133"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3133"/>
    <dbReference type="InParanoid" id="A8Q7V3"/>
    <dbReference type="OMA" id="RFMADIQ"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="39"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="349" mass="39412" checksum="3C33404A5C152F16" modified="2008-01-15" version="1">MLRMTEPETIAIDKELQLDWDLYRDVPDAIVQEEGLLLDYFRKLKFIYLEQETKLRFLADLQDDPETGLEPQILSTADVAHREQECKRVKQQLVEAKTRVRHLRTAIDSIAHAMEEPCDALDAEVAQAARLLTDITDMELELAKTKAAERTHGAMTTTEAEAVCDDQILAMQAIDDETTRTMQDVEAARKELAESVRTLDRLKAERAAAEKLANDARLGMGRDRGRDWELERLCAKHTSTLESLEHALGIVQMTAPNANELHIIIARPTAKRARRRSTRKSTAAEEEGEHRTLVLRFQEPGGPLASMELWDADSTTPVAMDQELVQLTKQAIHTNHAAAIVQAVWRSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q832</accession>
    <name>A8Q832_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase SUB2</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP-dependent RNA helicase sub2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">MGL_3192</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729648.1">
        <property type="nucleotide sequence ID" value="XM_001729596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q832"/>
    <dbReference type="FunCoup" id="A8Q832">
        <property type="interactions" value="712"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q832"/>
    <dbReference type="GeneID" id="5853954"/>
    <dbReference type="KEGG" id="mgl:MGL_3192"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3192"/>
    <dbReference type="InParanoid" id="A8Q832"/>
    <dbReference type="OMA" id="YAHVEPK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="83"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="286"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP42434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="435" mass="48728" checksum="0BD9CDCD3845733F" modified="2008-01-15" version="1">MENEDLIDYEEEVSVPPSGTTQADTNASAGAAPAGDGDEGNKKGSYVGIHSTGFRDFLLKPELLRAISDLGFEHPSEVQQECIPQSILGMDVVCQAKSGMGKTAVFVLASLQQLEPVDGEVSVLVLCHTRELAYQIRNEYARFTKYMPEVRTSVVYGGTPIKEDQAMLADKAKCPHILVGTPGRMNGLVRDKSLKAGDVKHFVIDECDKILDNLDMRRDVQEIFRATPHHKQVMMFSATLAKEIRPTCKKFMQNPLEIYVDDETKLTLHGLQQYYVRLEEAGKNRKLNDLLDTLEFNQVIIFVKSISRANQLDQLLRECNFPSICIHGGLPQDERIKRYQQFKNFEKRILVATDIFGRGIDVERVNVSISYDTPSDADSYLHRVGRAGRFGTKGLAITFVSSDEDAEVLKQIQSRFEVAVPELPETIEASTYMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q839</accession>
    <name>A8Q839_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729652.1">
        <property type="nucleotide sequence ID" value="XM_001729600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q839"/>
    <dbReference type="STRING" id="425265.A8Q839"/>
    <dbReference type="GeneID" id="5853958"/>
    <dbReference type="KEGG" id="mgl:MGL_3196"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3196"/>
    <dbReference type="InParanoid" id="A8Q839"/>
    <dbReference type="OMA" id="NIHIAMW"/>
    <dbReference type="OrthoDB" id="3356264at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728127" description="Transglycosylase SLT domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="73918" checksum="8D124CD6B2F230F9" modified="2008-01-15" version="1">MKYCSAGPSMIRWSLVGIVIAALICTSCVEALPHRHLNGRLLHARNTPDEHQAVPTSSTVDVPSALESTVSEVFDKPRIGVTKEGHKVPSYGKRNETERKKLAEELHRSIQKQLEQESVNGGVELDLSSILGDMYNGRLKVEGEMDKKHNKTDVSETIPKSKSSSSRSKSHSSSSSSSSESKSVTSSSSKSRSSSSSSTTSSLSSSSTSKTKSPASSSSLSSTSKTSTIKTSSSSKMTTKRLSSSSGSTSSSKKSSSSSSSKPSSSSKPSSKTSTSLSNSQTTTSKSPSPKGRTAARVGNKLGHGGFYRIAKDSPASSAQRLGHSSVNGGRVASVSADEPHGNLPNQSVITNNPSYGFLEAQDDLYTIRKWAGDLGKLASKKNRNETIMALFNAASRYYPDVDTKVVVRIMLADIKAESDFQKSNQSPGRVDSGDSLGLLQVSPYGSGELKQFQNMVQVEHNTYSWAIGTASEGEVDGGGRSELGALVDFKTNKRIDLDSLSEDDLSRPWINIHIAMWIQSNLARTGSQDPSSWKKIASNSKAVRKAYAPAMKQIISSIEESSNNDDTDSREAAAWSNSSSSSSSSSSSSSSSSWDKEEYATKLKALNKQLKGSHSQKRSFATGLGSWVAGPSADDSSGYNRSGDDVSNNYFKNIGEGLSVMYTGSTSHRDKYGKSYLESIELVGGLVDYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q882</accession>
    <name>A8Q882_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729678.1">
        <property type="nucleotide sequence ID" value="XM_001729626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q882"/>
    <dbReference type="FunCoup" id="A8Q882">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q882"/>
    <dbReference type="GeneID" id="5853984"/>
    <dbReference type="KEGG" id="mgl:MGL_3222"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3222"/>
    <dbReference type="InParanoid" id="A8Q882"/>
    <dbReference type="OMA" id="DRINYYC"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725507" description="Glycoside hydrolase family 5 domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="130"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="459" mass="52562" checksum="A8861F106BB24E4D" modified="2008-01-15" version="1">MVKSTFLSFLSVAWIAALALSVSGAFAEPRMVRRGRISVQHGLSKRLNSSAQDVERAGDRMEARADSKLRFNYGTDKVRGVGIGGWLVIENFITPSVYERTGDDRVIDEWSFGKYVPHDKAVKILRDHYDNFIKESDFEEIASLGLNHVRIPFPYWGIKTYDDDPYIKLNQYDKLKEAAHWADKYGLKVIIELHTVPGLANPYDHGGHTGHMDWLKYDVNKDRWLEILDELASEFSQSKYPAVTAISIVNEPNGDVNEILGQYKRGYNRVRNSESDAELVVIIGDVFLNVAENDYWHTRMQPPKYQGVMTDTHVYRIFDADSISLSQQDRYKYYCSLKGGLAANNHLWALIGEWSPVFTDCAPGLNGRFKGARYDGSFPDSTYHGSCDGKSGNAKNFSDHYKRLLRKNWDIQTDAYEAGAGWIMWTWRTENHNADDWSYRQGVRHGWIPRDPTQRKSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8L9</accession>
    <name>A8Q8L9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Pyruvate kinase</fullName>
            <ecNumber evidence="5 15">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_3294</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 15"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729750.1">
        <property type="nucleotide sequence ID" value="XM_001729698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8L9"/>
    <dbReference type="FunCoup" id="A8Q8L9">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8L9"/>
    <dbReference type="GeneID" id="5854056"/>
    <dbReference type="KEGG" id="mgl:MGL_3294"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3294"/>
    <dbReference type="InParanoid" id="A8Q8L9"/>
    <dbReference type="OMA" id="RVHHIGE"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="23"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="383"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP42536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="521" mass="57723" checksum="B11FDE104B480C91" modified="2008-01-15" version="1">MSQIEWFASLNPIEHNFENAYLRKTSIIATIGPKTNSVEMLHKLRNAGVNIVRLNASHGDHGYFQSVIDNCRQVEREAPGRPLAIALDTKGPEMRTGVMIDNQDVPIPAGHEMIVTTDEYYADKCSAEYLYIDYPNLPAKVVPDRLIYIDDGILSLRVLRIEGNNVFVRSENHGTLSSRKGVNLPLTEVDLPAVSEKDVKDLVFAAEQEADIVFASFIRTRDDIVKIRSLLGKRGGHMRIIAKIENHQGLQNFDEIMAEADGIMVARGDLGIEIPAPQVFLAQKMMISRCNIAGKPVICATQMLESMTQNIRPTRAEVSDVANAVVDGADCVMLSGETAKGAYPVESVRYMAETAYMAERSLSYQAIFNQMRSLLRPSTMTNETIALVAVSASLEQKADAILLMSTSGETARLVSKYRPPCPILVVTRNIYTTRTCHLSRGTYPFHYPLPHIEDMSRWQEDVDNRIKFGLSEALKLGIIKKGGTVVAVQGWRGGRGYTNSLRILTVPTTSEGYILESTTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8T6</accession>
    <name>A8Q8T6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729303.1">
        <property type="nucleotide sequence ID" value="XM_001729251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8T6"/>
    <dbReference type="FunCoup" id="A8Q8T6">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8T6"/>
    <dbReference type="GeneID" id="5853616"/>
    <dbReference type="KEGG" id="mgl:MGL_3338"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3338"/>
    <dbReference type="InParanoid" id="A8Q8T6"/>
    <dbReference type="OMA" id="ICQQRFY"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09090">
        <property type="entry name" value="INPP5c_ScInp51p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="6">
        <location>
            <begin position="48"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="808"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="849"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="894"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="904"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="916" mass="102225" checksum="E987C18819A3C34D" modified="2008-01-15" version="1">MPGQHIQRVRNVSFFCLTRRLPNDIALAQGMVDASETSSSTDDPCAAIRKYMTAGSFYFSRGPYDITQRVQTHGTTPGLFHAQFLWNASMMEPIETFVSRLEAHRKEALECDHFFLYVIQGYVGVQTIPSVIPCRLAVVSRLSSSRAGTRFNARGIDDEGNAANFVETETVLVADDVVFAFTQVRGSVPVFWEQQGLQALNTRIQITRTGAASLPGFLSHMDQLFDEYRRVFVLDLLGTRDVETTLAQAYVQHLRAIYDTRPVKYHNFDFHGVSKAMGGIEGVKTELDRLNNVQTQRQYNRYALLYHGKVLERQTGVFRINCFDCLDRTNVVEGMLSHAALRDFFRELKYNNRSVPTLEKISAETSMPNAIWQAHRELWANNGDALSVISTGTGSLNSNFMRTGTRKGLTGLLSDAAKSASRMYVNNFQDQSKQEAIDTLLGARSGQRRIELYDPRYSRVSEALERRWAEYASVHSMNVFVGTYNVCTRAPQGLDMRSWLCPSTYHQAPADIVAIVLEELVPLNAQQLLQSAKEELESWKLAVTRTLESTGVQYELLRHELLFGTALLVLVKSDVLPHVKNVEGTTKKTGFRGMSGNKGGVAVRLDLFDTSVCFVGSHLPSGASNYEDRNADYAAIERNLVFMRGRTIESHDHIIWAGDLNYRIGNLSPEDVRDFASRKVLAPLLEGDQLTHARKLGDAFPNYDEAPIQFPPTYKYDIGSDIYDTSEKLRPPAWTDRILFKCKLPSLYVRTHGYDCAPIRVSDHRPVYVHLELGICTLDSAHRDEIYESLVNDMKEQSEKHGDEITRTLLPPPSTDTQQWWNKATDTPLSSTLGDDKVRGNPFLLAQTGTAAPTTTPVCSKKEEVDVAASGTSPTANTPLSPPKSRRSPPPIPARSAATVAAAPPIPPRPNPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8V7</accession>
    <name>A8Q8V7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729309.1">
        <property type="nucleotide sequence ID" value="XM_001729257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8V7"/>
    <dbReference type="STRING" id="425265.A8Q8V7"/>
    <dbReference type="GeneID" id="5853621"/>
    <dbReference type="KEGG" id="mgl:MGL_3344"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3344"/>
    <dbReference type="InParanoid" id="A8Q8V7"/>
    <dbReference type="OMA" id="FENASPF"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="307"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="693" mass="77299" checksum="F212EFE38A45A2BB" modified="2008-01-15" version="1">MSVQRARSGTSLTRPPLDRRRASLFLGKDEERWAHMIADPASDSPWKVIKSVMVSPPRTWENHDPITHKFASSLGIAPASAQTRNVHDIESSLMPAHDEEVPASAFVSSDYRPIPTPSTGTSAVHPFRQCGDRTVAPQASALLSPTSLTAKNDASLLPRGSPSRMDMSHPILSDSLSSILLEKASLDVYPDDAVVKTTTRNVSAASSASRFMEKASAAWCQYEPTLEARRDRRSKLLRSALKDYVPTPRTGSPEPNVQSELQLLDQMYDKKDILSLVPRRSIEHVEGTLYDEDGPFREGATSDSLSVRLFYAPGPSGEGISFLITTPDNRVFSAAKRRRWAMDQYGNFFAAMEIKSVESKLRVAKNETVDPLYAREYEADLRRHYIDDILDELQKAETLTPVQSAVKPHVLRTEDNKIVRLEEDFPEEAFFVIAGCQDHEIMPVMARVFADAILLLWRMHCHGWMHGDIKLENLMFNQKGVLYIIDFENASPFRGSAQHDGLIQLLSFDWTPPELEISPLGRRMGPTGDLFALGSNIIRGFALRDGITDKTVRDMLMGDGLGIFISFRNTLLTSSASMPDAPPVHYNVNLVPLLLAADTETTPIYLNPARVLRIFACRAPKLLQYILAHCVAPSPYERNERFGVELAHELLHDPANAGMWETVKKALDTSIELSGSSWVRPKLNEARDILELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q948</accession>
    <name>A8Q948_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3411</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729376.1">
        <property type="nucleotide sequence ID" value="XM_001729324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q948"/>
    <dbReference type="FunCoup" id="A8Q948">
        <property type="interactions" value="707"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q948"/>
    <dbReference type="GeneID" id="5853683"/>
    <dbReference type="KEGG" id="mgl:MGL_3411"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3411"/>
    <dbReference type="InParanoid" id="A8Q948"/>
    <dbReference type="OMA" id="KYGRTNE"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="268"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="509" mass="57389" checksum="382546708B67D7E4" modified="2008-01-15" version="1">MNDTSDFMIKPDNSGPSLRFSEWPLLLKDYDKLLVRSSHFTPIPHGCTPLKRDILTYVSSGVINLDKPSNPSSHEVVAWLRRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVAVLRLHDKLDDVSKLPRVLETLTGALFQRPPLISAVKRQLRIRTIYESKLLEFDNDRHLAVFWVSCEAGTYIRTLCVHLGLLLGVGGHMQELRRVRSGALSEDDNMVTMHDVLDAQWLYDNQRDESYLRHVIRPLESLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRFESNIELNDEVVLITTKGEAIAIGIAQMTTVDLSTCDHGIVAKVKRCIMERDTYPRRWGLGPKALEKKKLVKEGKLDKHGHEIEGVTPEKWSKEYVDYSKPDADRAADEPTTGPDTSMMSKSEAADDDDDEANETEAEDEADIEPEAGDASSSEKAKKRKADADSEDREETEEERKRRKKEKKAAKKALEAAGETSEKKEKKDKKEKKEKKEKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9J0</accession>
    <name>A8Q9J0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729455.1">
        <property type="nucleotide sequence ID" value="XM_001729403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9J0"/>
    <dbReference type="GeneID" id="5853762"/>
    <dbReference type="KEGG" id="mgl:MGL_3490"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3490"/>
    <dbReference type="InParanoid" id="A8Q9J0"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727274" evidence="3">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="140" mass="14479" checksum="1181987DD24CC60D" modified="2008-01-15" version="1">MRTYLLVVLLAIATVALARIPVSESTSGVAGVVDRSSMGKDLSSHESHHSKTKSESSSNARHSKTLSTVTQPSEKANAVKGASATTESARSMLSSAMSSASSVSHTGGGVSSVKIPFWMSNFPTLALTVGFFLSVFAIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9Q2</accession>
    <name>A8Q9Q2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoporin Nup37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729499.1">
        <property type="nucleotide sequence ID" value="XM_001729447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9Q2"/>
    <dbReference type="STRING" id="425265.A8Q9Q2"/>
    <dbReference type="GeneID" id="5853806"/>
    <dbReference type="KEGG" id="mgl:MGL_3534"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3534"/>
    <dbReference type="InParanoid" id="A8Q9Q2"/>
    <dbReference type="OMA" id="INDLAWC"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037626">
        <property type="entry name" value="NUP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806">
        <property type="entry name" value="NUCLEOPORIN NUP37 P37 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="40513" checksum="0A7615754774BBBA" modified="2008-01-15" version="1">MPIWYVKTFSPLATDTSVHVYDTHGQHDPPSVLFRPVTSFFLGCRITSAAWSPSTRCIRDSDDADSWQIEILVATDVDELRLLTASSDEDVPTSHKKVADLHARVLDVAWCGSSGYESFVATACADGAVQVWNLEPENSSDSATCQTHYLDSAVLSVAFHTKMPKLLLAFESGGVGYCIDWLASREELRTTASFHEPMTVGLHATQGYDAQGAAAWQSQDADIVGALLGTRWSVWNMSMGHVPVASGQLHQTSATGYGGFRFCPTNSRLFAVFVSTLSHHVLAHSGYSTSTSGLAGSTAAVYIFDSAFPSSPRAVDVHRQTPLRGGSVSLDATGHDDSATLPTAYGVQSIDWLPRRVGPYDVLLVGVGHHVVPIPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9R9</accession>
    <name>A8Q9R9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3547</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729512.1">
        <property type="nucleotide sequence ID" value="XM_001729460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9R9"/>
    <dbReference type="FunCoup" id="A8Q9R9">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9R9"/>
    <dbReference type="GeneID" id="5853819"/>
    <dbReference type="KEGG" id="mgl:MGL_3547"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3547"/>
    <dbReference type="InParanoid" id="A8Q9R9"/>
    <dbReference type="OMA" id="VHFTTRI"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="147" mass="16338" checksum="AD14BD273078133A" modified="2008-01-15" version="1">MAMKRISKELADLGRDPPSSCSAGPTGDNMFQWQATIMGPSDSPYSGGVFFLSITFPTDYPFKPPKVSFSTKIYHPNINANGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPDIAHLYKTDRAAYENTAREWTRKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAD9</accession>
    <name>A8QAD9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3698</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729231.1">
        <property type="nucleotide sequence ID" value="XM_001729179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAD9"/>
    <dbReference type="SMR" id="A8QAD9"/>
    <dbReference type="FunCoup" id="A8QAD9">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAD9"/>
    <dbReference type="GeneID" id="5853537"/>
    <dbReference type="KEGG" id="mgl:MGL_3698"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3698"/>
    <dbReference type="InParanoid" id="A8QAD9"/>
    <dbReference type="OMA" id="HRYISIL"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="50"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="251"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="455" mass="50578" checksum="E0B583CBDBE61C9D" modified="2008-01-15" version="1">MPRELITLQTGQCGNQIGSQFWEHLCREHGISKDGTLEEFATEGQGGDRKDVFFYQADDEHYIPRAILVDLEPRVINNIMTGPYKSLYNPENLYRNVSGGGAGNNWAQGYAAGEKAADELIEMVDREADGSESLEGFFLLHSIAGGTGSGLGSFLLERLNDAFPKKLIQTYSVFPNSEETSDVVVQPYNSVLTLKRLVNNADSVVVLDNAALSRIASDRLHLQNPSYHQTNQLVSTVMSTSTTTLRYPGYMNNDLCGILASLIPSPRAHFLMTSYTPFTSDNVDRGKATMKTTVLDVMRRLLQPKNRMVSMTGASKTSCYMSVLNIIQGDVDPRDVQKSLLRIRERHLASFVPWGPASIQVALSRRSPYVASSHRVSGLMLANHTGIASMFKRTADQYDRLRKRNAFLDMYKREAMFSSDLSEFDEARETVTELMAEYRAAEKDDYITGGGVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAG3</accession>
    <name>A8QAG3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">P-type Na(+) transporter</fullName>
            <ecNumber evidence="20">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">MGL_3722</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="20"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729255.1">
        <property type="nucleotide sequence ID" value="XM_001729203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAG3"/>
    <dbReference type="FunCoup" id="A8QAG3">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAG3"/>
    <dbReference type="GeneID" id="5853561"/>
    <dbReference type="KEGG" id="mgl:MGL_3722"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3722"/>
    <dbReference type="InParanoid" id="A8QAG3"/>
    <dbReference type="OMA" id="NGQEYSM"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000058">
        <property type="entry name" value="Probable ENA2-Plasma membrane P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="786"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="823"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="868"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="961"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="999"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="38"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EDP42041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1042" mass="114891" checksum="9A1816803D8048B9" modified="2008-01-15" version="1">MNSKTQSLSSIEKNAAFDDKQLSSAYSAPPSEEEAREFPHRYDARAVLEALRSDKSKGLTTQEARERLKHYGNNELSSGDSVSPVKILINQIANAMTLVLLIAMIVSLAITSWIEGGVIGGVVGINVFVGFIQEYSAEKTMSSLRSLASPTATVIRDHNSMTIPAPEVVPGDIVELATGDTIPADGRVIECMNLETDEALLTGESIPVAKNAQDTFQPTGPENDEVGIGDRLNMVYASSSVSKGRATVLVTSTGMRTEIGKIADALQGASKNRKIREVKRNAYGKKRPHHYIEAGALTIMDHVLAFLGLNVGTPLQIMLSKLAVLLFVIAVIFAIIVFASNNWHDNEVIIYAVATGVFDDPSITDSRTDHYNVHGKSCDGTLTQGKMVVRKIWLPSVGDLDVSETNEPFNPHKGEVTLRPNDEKSDCVTVASEGRPQEDLSGKLQPLHDMLLVTSICNLAKVFYDEDADAWTAHGDPTESALQTLAFRFDMPKTKIGKSEDNVNGEWVQIGEYPFDSSLKRMAVTYTYQPTGEHRALMKGAVEYVLAACRYIQTKPEDHGKEEMNENVKDMIISQMNAIAKLGLRVLALAHRPLSDKEASQGESLERESVESNMVFLGLVGLYDPPRPESRDAVHTCHTAGIEVHMLTGDHAGTAKAIAEQVGILPPNVDEKTSSLVMTAAEFDRKSDEEIDQLPELPLVIARCAPQTKVRMIEALHRRKRFCAMTGDGVNDSPSLKLSDVGIAMGMAGSDVAKDASDIVLTDDNFASIGHAMEEGRRMFSNIRKFVLHLLAQNVGQACVLLIGLAFKDDTGLSVFPLSPVEILYIIMVTSGFPAMGLGMEAAAVDVMKQKPNRSRFGVFNLEVLCDLLVYGLIMAALCLATFSLILYRWGSGDLGLDCNDSYNDSCLEVFRARGATFVVMTWFSLFLAWEVTHMRRSFFAMGTDAHWYNQWFVDTWRNKFLFACVILGFISVFPIIYIPGLNHIVFLHKDREGWEWGIIFVCTAIFFLGVESWKYIKRIYFRRAERIEARSASKHKGDDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBU1</accession>
    <name>A8QBU1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3941</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728947.1">
        <property type="nucleotide sequence ID" value="XM_001728895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBU1"/>
    <dbReference type="STRING" id="425265.A8QBU1"/>
    <dbReference type="GeneID" id="5853253"/>
    <dbReference type="KEGG" id="mgl:MGL_3941"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3941"/>
    <dbReference type="InParanoid" id="A8QBU1"/>
    <dbReference type="OMA" id="WATAKSM"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="269" mass="30368" checksum="9F2F2BA4217A9997" modified="2008-01-15" version="1">MLRRIPHNLNQQSCDATVHLIQGVLNSGVDVTKIFVDTVGEPNAYAAKLKQYFPRHSHIEWIVARKADATYPIVGAASIAAKVTRDACVDHWMYAEPLQSVHHPEISKSSGKRKRGNNDDEETDIWATGSGYPGDPKTVRYLKETLDPVFGWARLVRFSWATAKSMLEEPVHVRQDLTSMLGTTYPSSTRAYPVRWIDDAQKQGKQQSTLANFFSKQQKPASNRRSITTQATAPDTRQVWLNDRKLLSEHQPHLWQQLALAPSSATDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC26</accession>
    <name>A8QC26_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chalcone isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728973.1">
        <property type="nucleotide sequence ID" value="XM_001728921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC26"/>
    <dbReference type="STRING" id="425265.A8QC26"/>
    <dbReference type="GeneID" id="5853279"/>
    <dbReference type="KEGG" id="mgl:MGL_3967"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3967"/>
    <dbReference type="InParanoid" id="A8QC26"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chalcone isomerase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="139" mass="15207" checksum="1D2B5431331AB2E5" modified="2008-01-15" version="1">MPTRSTDFSHLRDGLIRAINVRAKDARLPSASYELSDEAEGTLSKNLTELKSLFPRFKVQRGHTLDIIVQKTRLNTYLLSLQYNGKELGTVESAPASTSGTLPPFTLPTTLLLAYVGTHPDISEPLRKSIASGLEDGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCK5</accession>
    <name>A8QCK5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_4019</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728852.1">
        <property type="nucleotide sequence ID" value="XM_001728800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCK5"/>
    <dbReference type="FunCoup" id="A8QCK5">
        <property type="interactions" value="527"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCK5"/>
    <dbReference type="GeneID" id="5853158"/>
    <dbReference type="KEGG" id="mgl:MGL_4019"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4019"/>
    <dbReference type="InParanoid" id="A8QCK5"/>
    <dbReference type="OMA" id="RCQEIDY"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="303"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="519"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="171"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP41638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="815" mass="91056" checksum="EED64557D348E178" modified="2008-01-15" version="1">MDDGGAGVSSILRRDFSRMPLKLDHNSRPLWISPDDGHIILEGFNALAEQAQDFLIAIAEPVSRPNFVHEYKLTPYSLYAAVSVGLEPDDIIEVLNRLSKVSVPKSVLDFIREYTMSFGKIKLVLKQNRYFVESSHPEILQMLLRDPVISEARVRPGESANDLPIATHTATTTAAAAPSTEVEHPSASNGAAKSAHTSSAAGGGGSQQTATVGPEASKESEQDLFSAVIGVYDADELDEDDAVHSFEIREEQIEAIKRRCNDLGFPMLEEYDFRNDMLNPDLEIDLKPITHIRPYQEKSLAKMFGNSRARSGIIVLPCGAGKTLVGITAACTIKKSCLVLCTSSVSVMQWRQQFLQWSNVQDSQISVFTADEKEKFSGASGIVVSTYSMVANTGKRSHTSQKMMNFLESREWGFILLDEVHVVPASMFRRVLTKIKAHAKLGLTATLVREDEKIDELNFLVGPKLYEANWMDLAAKGHIATVQCAEVWCPMTAEFYREYLRERSRKKMLLYCMNPTKFQAAQYLIHYHENRGDKIIVFSDNVYALEAYAIKLGKPYIHGGTPQIERMRILQNFQHNPIVNTIFLSKVGDTSIDLPEATCLIQISSHFGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSRDTAEMFYSTKRQQFLIDQGYAFRVIMNLVGQENMPGLVYSSKSEQIELLQSVLIASESAADFGSDVKPGESASAAPSAKRMMGSLNALGGAHTCHMLSETASMNKSLLHDQPRHKAFQKRAANAQIITKLNRLTKQSLVLPVPKFAPFPFSTRHNPCLTHFGKTFPQFFWQSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCP2</accession>
    <name>A8QCP2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_4031</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728864.1">
        <property type="nucleotide sequence ID" value="XM_001728812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCP2"/>
    <dbReference type="FunCoup" id="A8QCP2">
        <property type="interactions" value="669"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCP2"/>
    <dbReference type="GeneID" id="5853170"/>
    <dbReference type="KEGG" id="mgl:MGL_4031"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4031"/>
    <dbReference type="InParanoid" id="A8QCP2"/>
    <dbReference type="OMA" id="IKYAWYE"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="7">
        <location>
            <begin position="98"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="6">
        <location>
            <begin position="417"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="8">
        <location>
            <begin position="587"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="790"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="886" mass="96751" checksum="A13E40FEA83130F8" modified="2008-01-15" version="1">MDGTNGADESIRAWNFVPISLFVSSGAWRVPELASPDKWPSYPGLKPLREASHANALDTIVGPTPASIGVHDKTTTSAAELKQMTDVEKCRHWACADGYDGIAVELTNARWRERWEHLCLRVDSDTLPRSSSRANLSAADAMDSRVQFEAEGWRAHPHFTRSELNILKPSEAPLVMAILSQWLELDSPDEGVRFDSEIALRQELAHAAYVGIEEVILPPPSSDPERQSYLADYARAVRSCLTSMAGQAPVTNASMKVAIRLPVSSPHILASMLVHQATKGPHGSAAMPAAAYLRTKDNWAWETWEKLQELCGYHPQLYVALDLSMPLPPTSSMMRWINEPVSHLWLPSSSFLANAKGYPVLSKSAQTLVQYLVPHGPHIVLSDITSPPPQHTRGGPMAYVQYVRHLMKVMKAPTKLEKLALKVGDCLQAPLEPMSDNLAGVTYGVFEADSVKYRLYEEAMFQAFSQLGTPTTRLRVWIVGAGHGALVSRCLAAAERASRWVHITALEKNPGAFINLQDRQLSEWGAEHVHVLLGDMRNISVPTNVSERADVVVSELLGSFGDNELAPECLDGAMRLLKPGGISIPGSYMPYIVPITAPKLHTTIKSGTMNRADAASLAGEGMGTAMNTAAKFDAPSVVLFKSMSFLSGLDSACQYPRVQPCWRFEHTSMDESGLACGRTGLPLTNSHNARSSMNTFYIPHAGVCHGLAGYFEAHLFGSVVLSIFPDPARASPDMLSWFPMFFPFRTPLYVPAHSQLDVHMWRLTDNHHVWYEWSAESYLCVDSPSLHASSASASPKPVSTPMVQQDESRQSESLPPFSNAPHTPMVPPSALMGTGVSQADTLESAANPGVDANSLVYSPLKRRIKTGQTDLMNAGACGFKLTISTS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCV7</accession>
    <name>LIP5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Secreted triacylglycerol lipase LIP5</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
            <ecNumber evidence="5">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LIP5</name>
        <name type="ORF">MGL_4052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Microbiology" volume="162" first="1069" last="1079">
            <title>Secreted lipases from Malassezia globosa: recombinant expression and determination of their substrate specificities.</title>
            <authorList>
                <person name="Sommer B."/>
                <person name="Overy D.P."/>
                <person name="Haltli B."/>
                <person name="Kerr R.G."/>
            </authorList>
            <dbReference type="PubMed" id="27130210"/>
            <dbReference type="DOI" id="10.1099/mic.0.000299"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Secreted lipase involved in Dandruff and seborrheic dermatitis (D/SD) probably via lipase-mediated breakdown of sebaceous lipids and release of irritating free fatty acids (PubMed:18000048). Has triacylglycerol lipase activity and is able to hydrolyze triolein (PubMed:27130210). Mostly converts monoolein to di- and triolein, while free fatty acids are only produced in low amounts (PubMed:27130210).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EC" id="3.1.1.3" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728885.1">
        <property type="nucleotide sequence ID" value="XM_001728833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCV7"/>
    <dbReference type="SMR" id="A8QCV7"/>
    <dbReference type="ESTHER" id="malgo-a8qcv7">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GeneID" id="5853191"/>
    <dbReference type="KEGG" id="mgl:MGL_4052"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4052"/>
    <dbReference type="InParanoid" id="A8QCV7"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727306" description="Secreted triacylglycerol lipase LIP5">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="129"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="W3VKA4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18000048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="475" mass="52078" checksum="7CABE7C333D975F1" modified="2008-01-15" version="1" precursor="true">MYPCTLLMVLLCLAIMTHGHIQIHGTGMRRNRRDSPHPPSPIYDSFYVPKKGWDETKPGTVLASRNIQAGFTKTQKINLDGAYQLLYRTSGVDDKSPSYSVTTVLVPKNARPNKLVLIMAYEDSNFVECAPSYKIQLGAPLETNPIQTVEELMWTSVLNDGWTVTIPDHQGPLSAFSSSFIHGHASLDAIRATLNFEQLKLDPKSAVVGMGYSGGAIAGGWAASLLGSYATELNVVGWSIGGTPSNVTGTFYGLDGSLFSGFSVAGVAGIVDSYPEVNDYVGSVITPAGNAALQFTREHCMGDIVVGLQNVNLTGKDFVKNEKNFLTDKRIAPILDHLTMGTDSKLTPKVPVYMYHALHDEVIPFDRANQTANAWCKGGANLLFQEYTGIEMGHVSTEVLNTPFVLKFIRDRMSGREFLNGCQWKSDLNPLWRPDILGARLTEVFNSILNFFGTSVGRTDRIIQESIINHNFTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCZ0</accession>
    <name>A8QCZ0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_4059</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728724.1">
        <property type="nucleotide sequence ID" value="XM_001728672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCZ0"/>
    <dbReference type="FunCoup" id="A8QCZ0">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCZ0"/>
    <dbReference type="GeneID" id="5853075"/>
    <dbReference type="KEGG" id="mgl:MGL_4059"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4059"/>
    <dbReference type="InParanoid" id="A8QCZ0"/>
    <dbReference type="OMA" id="AHTSAWD"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="36"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP41510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="697" mass="77654" checksum="0F89BF4F815974DA" modified="2008-01-15" version="1">MASNQAQASSGSDINVTLQFGSGGDPQQHGGEGNLTTNQGIIVSDNQNSLKAGTRGPTLLEDFVLREKIFHFDHERIPERIVHARGSGAHGYFEATEDISHLSRAHVFKKGTKTPVFARFSTVVGGAGSVDTPRDVRGFSVKFYTDEGNWDFVGNNIPVFFIQDAIKFPDLIHAAKMEADRGYPQAATAHDTFWDCATLMPESTHMQLWAMSDRGLPRSIRMMEGFGIHTFQLVNERGDAHFVKFHWKPKLGVQSTLWDETTKIQGANNDYHRKDLFESIESGMYPEWQLGIQVFDKEFADAQPYDVLDSTKLIPEEDVPVKFIGRMVLNRNPDNFFAETEQVAFCPSNVVPGIDFSDDPLLQGRLFSYLDTQKSRLGTANFHQLPINHPKVPVRNFQRDGMMQMSIPKGRANYEPNSLYEADEPTGPRACPFAAAFRTSDEVIGPRQRGPKLRARDERFADHYSQARQYWKSLTESEQNHTVGGFVFELSQVSLPHVLKRAVANLRNVDESLARRVAQGLGIELPEKSKSLREPVDLPASPALSIQRNAKQTIEGRSIGILINEGSDKDKIEHLKNMIREHNGVPALIAPRAHGIKLSDGSKVDVDGILAGMPSVVFDAVAVVLSKEGTDKLVKELTAVQWVQDAYAHLKAITYTKESQGLLEKAGVDMNVRGISTDLGAEFIKNAGTRFWERELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCZ3</accession>
    <name>A8QCZ3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative 5'-nucleotidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728726.1">
        <property type="nucleotide sequence ID" value="XM_001728674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCZ3"/>
    <dbReference type="STRING" id="425265.A8QCZ3"/>
    <dbReference type="GeneID" id="5853077"/>
    <dbReference type="KEGG" id="mgl:MGL_4061"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4061"/>
    <dbReference type="InParanoid" id="A8QCZ3"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="275" mass="30954" checksum="102B308667271B8D" modified="2008-01-15" version="1">MTDIVSPFRDEFFFVRDVPWHAAQRLVDGLNERGAAHNEQPGAMHPSQGAADSIFHRYLGHAFVTYWAQILGLQPGKESVSPPPTTSGRPESARRLDELLIRLTTDTDLANDLPHLLNQSYEQMPSLGYVTADSCPGQGDDTVHIPIPYSDIQPEYVASQPVHIPTDERELVDVVFVDFIADPLLHLLNLYDTKRTYTMQDVDVWGDISTQSLYSTYAQLHWRPQSIQEAWEYMDRAATAEGYPPLAQYDAYEGNPYASVTVSEKTRGLVFQPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD04</accession>
    <name>A8QD04_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit D domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728737.1">
        <property type="nucleotide sequence ID" value="XM_001728685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD04"/>
    <dbReference type="STRING" id="425265.A8QD04"/>
    <dbReference type="GeneID" id="5853108"/>
    <dbReference type="KEGG" id="mgl:MGL_4072"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4072"/>
    <dbReference type="InParanoid" id="A8QD04"/>
    <dbReference type="OMA" id="TRMDYLT"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="192"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="462" mass="51989" checksum="53F0F340F9CB7113" modified="2008-01-15" version="1">MVSMLPSTLRTVSVRAARGAMRPSVALARAMPRSFATEAEKKVENPTHTATTVEDLQGIDAATLLKEEGTQKDANLRHFTVNFGPQHPAAHGVLRLIMELNGEEILRVDPHVGLLHRGTEKLIEYKTYTQALPYFDRLDYSSMMTNELCFARAVEKLLNIEVPERAKWIRTLYGELTRISNHCMAVLSHIMDVGGLTPFVWGLEEREKIMEFYERVSGARMHAAYVRPGGVTYDLPPGLLDDIYHWATQFAGRVDEIEELVTGNRVWRERTIGIGKVSAKDALNYGFSGVMLRGSGIPWDIRKVAPYDAYDQVEFDVPVGKNGDCFDRYLCRIEEFRQSLRIIHQCLNKMPAGQIKVDDHKIAPPSRSMMKESMESLIHHFKLFSEGFTVPPGETYSAIEAPKGEMGVYLVSNGTNRPYRCSISAPGFRHLAGADFVARHHYLPDMVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD47</accession>
    <name>A8QD47_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728780.1">
        <property type="nucleotide sequence ID" value="XM_001728728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD47"/>
    <dbReference type="STRING" id="425265.A8QD47"/>
    <dbReference type="GeneID" id="5853072"/>
    <dbReference type="KEGG" id="mgl:MGL_4115"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4115"/>
    <dbReference type="InParanoid" id="A8QD47"/>
    <dbReference type="OMA" id="NHAPRAT"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="85"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="491"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="491"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="787"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="601"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="796"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="846"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="866"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="911"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1006"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1042" mass="108826" checksum="54C46A5C5C184F33" modified="2008-01-15" version="1">MFVSAPSVPPQRSRALSTPGKTSSSSHGVTGDVSRSLSRSASWTQESMCHTPSSITSTPAQEGPIRAYAKLEFPGFSYYIQTLQVTIGRRPQGVPPRPPHLPSPSGSAASSALPAPWFTPKDVDVDLGPLKSISRLHARIFYSAQPEFIRAPLYAPTSVLHHQVPATPATTSKNLGTHSGAPVANNANAGADADVAADDDQSDSALAATSPSSDSMPRSEGRFMLEVLGRNGAFVDDVWVSVHGVVPLGQRTKIQIAERVFYFVLPPPISSMDNAALDEGTALSGEDEAHDEDNDDGVALSSELSDMDTDAGANMVDSTGAHAKTETGSISADLEEERLRCSPTTLNSTDAPRPPKFVLKPRTKVTSTAVKRLRDDDDDDDEASDDAKRARPASGTVLHDKAKGKGKGKIKEKESDKDQVKEKNKASTKGKGKGKGKGTGKGAKSIKLEDSISSGDDNVIPVDDDDDDEAPLSLHKSSPATANSSMPVFQKPDLSNVQLITNALSSESCSRKGHKLTLQEVNEWLQNTYPWFSQNGRKTGRDWQSSIRHTISSSREFVKIPRRPDEPGKGIFYTLSGSELAKAHVAVRPEPSSAHADDTTSAHTTASSDLKPPSLSSVVTTVPSTSTSSSSSNRSSALLSTRNLSTSPSVNASPATLSVPTVAPTSASSAAPSAPPASSTLSSAAQHQTHPPHPSDTKRVMPRIPLVVGVPPQTESSASRAHSTPGSLESLLETPPIAHHQGKLYLSPSVFGHLTREQLDHIEGLGAQQALQILQTYLVTHLKAKMRKASSSPGVAPTTASARSPTPSSMPSSMESSASTSAAVASSLAATSRPAVSPAPSSTPTLGSSSATMPSQTLAPNHAPRATAGTLPTSASTPTAAPFTTSSFAQRLEAPKVPRIPVATKSETSIPPSASFQTTSQPSQATTSEMAPLPTSTPHIPKPADKQSDPLSAISALAAHPEAAGLITLLKKQQAGGHGTVKLTAGQLELLQLANRLAMQRKKKPGASPSSAGSSASGPSAPAPPDQIEQPQQHQQPSRPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD60</accession>
    <name>A8QD60_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nucleoporin protein Ndc1-Nup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_4128</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728793.1">
        <property type="nucleotide sequence ID" value="XM_001728741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD60"/>
    <dbReference type="STRING" id="425265.A8QD60"/>
    <dbReference type="GeneID" id="5853087"/>
    <dbReference type="KEGG" id="mgl:MGL_4128"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4128"/>
    <dbReference type="InParanoid" id="A8QD60"/>
    <dbReference type="OMA" id="HTLFDVY"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="424"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP41579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="68182" checksum="B4F026F6A94C28A0" modified="2008-01-15" version="1">MRPRQERILFLSTVASYLLLAASLLSPRALWQPCMLLGTLCLVVCVVLPLLLMRRTHLIHSTPPNELDRVPISRAAYARHILLAGDVWPSLGMHAVLGMFTVFIYASTAVCLQGTQKTALSPIRYVDVNQAYYVNETFLVTTASAACLGSLYAACSMLCFKGARRGVPPFDARHLGMPLYVHAMDALSSHIVRTLPVLCVWPVFFCVYVMVRDSFWTTVLRITGVDTVVRQAIVPSFRVPFHAWSMFASAVPVLVLMMVLMEVIHTLFDVYWTHPLPSIVSAYKDPITALLGGLTDNHAFFSTHAFAELTRLAKHDKAFRLAVYDDVQRLHGRPVAFPAISQACIRALDALAPAPEAKINSAAQQPLPSAKASGLATANTDTAAAAAAAAAAAAASKASKASRAPPPTSLSSSRFNIWQTLASRPASTSSSAKTSNPDASSASSKPLTSAPPTSAPSAAFLGKSLAQTVWKWIPSEAKHVLFPHTIHAALFAPESTLLLDTTLYVEAPRACFAAMAMESMVLASLTEDKYGSVQHQVQGLVEALSRAHTRMERVRQSAESLAVQADSQHVRDMSVWRGALADAGSDAAATFGPAFAPFFTEMQMAWSAYMCLDSALSRATRRITETFAAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDC5</accession>
    <name>A8QDC5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1753-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728705.1">
        <property type="nucleotide sequence ID" value="XM_001728653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDC5"/>
    <dbReference type="STRING" id="425265.A8QDC5"/>
    <dbReference type="GeneID" id="5852998"/>
    <dbReference type="KEGG" id="mgl:MGL_4184"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4184"/>
    <dbReference type="InParanoid" id="A8QDC5"/>
    <dbReference type="OMA" id="AWTVFFA"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29478" checksum="0D1118F60EBB07A0" modified="2008-01-15" version="1">MPRLYLRMPKSALTRYFTSFLGFMDIKVGCQIISLFSLFNKIAGVYGIIAVFQGGTFAQVSLYIYSIATIPLFIWGLNAISVEKHQSALRYAHLYFLDHMISTGWTVLFGVWWYNFAQHDGRPVTNSSHQAGLMSLIESLEAQYHTPEEMALLRHNTTSADTPEGAAEMALRTQRAREIWRAERGFAASVLCVGWLIKIYFAALLYAYALHLRHGTYWMLPLSKSRRANAVHASAQHSEPTETDEIAITEDNDAESTGNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDE4</accession>
    <name>A8QDE4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_4194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728715.1">
        <property type="nucleotide sequence ID" value="XM_001728663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDE4"/>
    <dbReference type="FunCoup" id="A8QDE4">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="GeneID" id="5853010"/>
    <dbReference type="KEGG" id="mgl:MGL_4194"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4194"/>
    <dbReference type="InParanoid" id="A8QDE4"/>
    <dbReference type="OMA" id="GHNFQIV"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728175" evidence="7">
        <location>
            <begin position="18"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="161"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="382"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="532" mass="59508" checksum="FBF99DE1F2F1610C" modified="2008-01-15" version="1">MRAASGLVALLATTAFGAEIGKQWSVGWVNDVNPDGKFPRRAIGINGKFPADPLSVNSDDFVHINFTNKFGDGRPSALHGHGLFFTNVNYYDGAASVTQCPVPDGYSFYHEILNSPKSGENAPKQWGTYWLHGHYKGQYIDGLRTPFIIHRSEGEVYEYDDDYTVVLADWYHHVHGYILHHDYFVKGGGYPTPDSGLMYFAHTKKGEEARTMPGMNENATLPFEPGKTYRLRLINMSAASVFDFWIDGHDMDIIEVDGVDVERYPIDSVQVAIGQRYSVLVKARNETDKNWMIHANMERGTFSKVGDLKLNLTSTVSYGGKGVKMGNEDQASKKGIRPMDDTLFVPKEVIETVEPDTRVTLVATVGSKNRMPFAAFNETAFVPPRRPAMLTMMSKNGSDVSVYGDKANAVIAPYNHMVEVTILNDSHDVHPFHMHGTRFQVVHRANGTKGQTPKVPDVKEQKNPIRRDTVAVDAWGSVTIRFRANNPGAWIMHCHMDWHLSAGLAMVMLQAPEEAHKVLNVPPYLKEQCKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8QEN8</accession>
    <name>A8QEN8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000037">
        <property type="protein sequence ID" value="EDP41372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728586.1">
        <property type="nucleotide sequence ID" value="XM_001728534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QEN8"/>
    <dbReference type="GeneID" id="5852895"/>
    <dbReference type="KEGG" id="mgl:MGL_4275"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4275"/>
    <dbReference type="InParanoid" id="A8QEN8"/>
    <dbReference type="OMA" id="EIGWGSK"/>
    <dbReference type="OrthoDB" id="3338260at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725278" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23100" checksum="F73A864770372247" modified="2008-01-15" version="1">MKVFSMAALSTLSIASVWAGMDCEKTSGPMSLQYTEIGWGSKYSNHTGLAKKGSDSHAFLRIQDGASREQFEFFECKSPPEGFETSPADAKYGQIRSAKDHSLCLTVQGIDNRPVYDYNHKAKGTKREYDRKNGYLTLEACSSHPRRQWWSDSISYVGMKKDQKRNHCSVDDDGKLFMYRNHAPSMMPHGGDSLGGFLTWESKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8QER1</accession>
    <name>A8QER1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_4279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000041">
        <property type="protein sequence ID" value="EDP41368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728582.1">
        <property type="nucleotide sequence ID" value="XM_001728530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QER1"/>
    <dbReference type="GeneID" id="5852890"/>
    <dbReference type="KEGG" id="mgl:MGL_4279"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4279"/>
    <dbReference type="InParanoid" id="A8QER1"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="73" mass="8898" checksum="564AB20B52554F7D" modified="2008-01-15" version="1" fragment="single">IFRRSLDGRWHQRRSHALVIRCSCRHHCLEWVVTCVRLIRHNRARHKRGPCTQVNRCSCRGRNKRECESDEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQX1</accession>
    <name>A8PQX1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732752.1">
        <property type="nucleotide sequence ID" value="XM_001732700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQX1"/>
    <dbReference type="FunCoup" id="A8PQX1">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQX1"/>
    <dbReference type="GeneID" id="5857058"/>
    <dbReference type="KEGG" id="mgl:MGL_0527"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0527"/>
    <dbReference type="InParanoid" id="A8PQX1"/>
    <dbReference type="OMA" id="EHNHNVV"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="250"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="341" mass="38031" checksum="880FF0717E657441" modified="2008-01-15" version="1">MAFAVGLSHVATVKDRTNEFRGVLSKFSAATPAPAAAPVSKRPTTAHAEFSRRAQAVARDLSHTTAKLDRLSQLARRKTLFDDRPVEISELTYIIKHDIAGLNRQLAELQQYSSNRSAKLNRADEHRGNVVTMLQSTLASTTTNFQEILEVRTQNMKASKDRSEQFFQGAAPTLDQQRSKSPLYTLARAQPPAAAPPASALHHRGSTSQHALRDEEAHSVDKGFLALDMMEAGGLQQQQLMLNEFEDQQSNYLHQRSSAIESIESTISELGQIFGQLAHMVAQQGETVQRIDDDVMHVSDNVEGARRELLKYYTSISNNRWLMLKIFGVLIVFFLLFILVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQX4</accession>
    <name>A8PQX4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="1">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732755.1">
        <property type="nucleotide sequence ID" value="XM_001732703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQX4"/>
    <dbReference type="FunCoup" id="A8PQX4">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQX4"/>
    <dbReference type="GeneID" id="5857061"/>
    <dbReference type="KEGG" id="mgl:MGL_0530"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0530"/>
    <dbReference type="InParanoid" id="A8PQX4"/>
    <dbReference type="OMA" id="IECTVVP"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="13">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="12">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="11">
        <location>
            <begin position="313"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="628"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="666" mass="72067" checksum="098A3F3CE6F70F9C" modified="2008-01-15" version="1">MPPVASLLLAHRPERRTMLVIGDGRLAQTRVRTAKEAGLETKLAWNAPVANISSDMYQVSTMALFPSKDDKENCIRAWEHILNEIDGPDASLFAVCVTDTLVAVPNDASSRRLRCEILAKACRTRRLPLNVTDTPELCTFSFPATHRFATDDEENASSLQLAVTTNGRGCRLAGRIRRHLVASLPASVGLAVERIGEMRELAKARTSCRGDAGELEDEPALNDALGYSSTAEDESDACAVQRRRMRWVAQISEYWPLERLASLDQTQMQALLENEMDASSRAQETSAVTEHVEPVAKRSRHDLDISKPRRKGHVYLLGSGPGHPALLTVAARDILTSPDTDVILSDKLVPTAVLALIPSTTPLVIAKKFPGNAEGAQSELISQALKAANEGKTVVRLKQGDPFVYGRGGEELVACQNAGIECTVVPGISSAIGGPLMVNIPVTQRGAAESMIMSTGVGRGGKRVMLPGYERSRTLLLLMGVARLPAVIETLTSCESPGRYGDAYPPYTPIAIVERASSEDQRLIASTLDRIVHVMDTHITDGQRPPGMLVVGWAVLSLTSTQVAGAHVLDDEADCYAEHEHDPARAAKQLAERDAARIDRWLGSRGFYIREGLPHGYDRFAQDAPALTRSLDDPTTLPRSSSGWAAPRYGEAMETPTLAPSSQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR58</accession>
    <name>A8PR58_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">MGL_0610</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732835.1">
        <property type="nucleotide sequence ID" value="XM_001732783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR58"/>
    <dbReference type="STRING" id="425265.A8PR58"/>
    <dbReference type="GeneID" id="5857141"/>
    <dbReference type="KEGG" id="mgl:MGL_0610"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0610"/>
    <dbReference type="InParanoid" id="A8PR58"/>
    <dbReference type="OMA" id="PISACYN"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727840" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="18"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="154"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="398"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EDP45621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="472" mass="51856" checksum="447BE9455A2E659F" modified="2008-01-15" version="1">MKLTLISSALLVVGASAKLHTPSTHVDYVRRALPSDAAGYAKLDNPTKECKYYTPPEMEQMLKDRLPKAGKVADILPNDDEAKKVWKEIQDTGIIPEEVKTKPDASNGKHAEVDIKSANYDADKDPDCWWSASQCTKPKHNKIPEDIAVCPEGSTYGLTFDDGPNCSHNAFYDFLKQKKLKASLFYIGTNVATWPYQAQRGLADGHDICVHTWSHPAMTTLSDSQVFAELFYTVRVIKAVLGITTTCWRPPFGDTDDRVRAIAAGLGLRTIHWREDTDDWQMASTGSPKQVRQNYDKIVDKASNESPIVLAHELHNDTMSIFIEKESKIADAYKHVAPVSACMNVTNPYMENQIVYPNFEEYTGGNANYKGLPDMSNMKINPNVDFSALSLAKMDTGFAPGGENKKQTDTGSATFSSDSSDDGSKNAKGSKDGGSGGKDNSHKENGAIQFSSLSLWAALLSSITITFVTFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRB2</accession>
    <name>A8PRB2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0012</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732237.1">
        <property type="nucleotide sequence ID" value="XM_001732185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRB2"/>
    <dbReference type="SMR" id="A8PRB2"/>
    <dbReference type="FunCoup" id="A8PRB2">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRB2"/>
    <dbReference type="GeneID" id="5856537"/>
    <dbReference type="KEGG" id="mgl:MGL_0012"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0012"/>
    <dbReference type="InParanoid" id="A8PRB2"/>
    <dbReference type="OMA" id="VDTARHS"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="305"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP45023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="660" mass="71171" checksum="7A2A22936B908A75" modified="2008-01-15" version="1">MALERGGADVIELGMPFSDPQADGPAIQESNRIALQQGVDYAMCLKYIKEARSRGLKVPVVLMGYYNPIMAYGEERAVHDAKSAGANGFILVDLLPEEAGTFLNACRREKMAFVPLIAPTTDVNRIRYLSSLADAFIYVVSRLGTTGVSASVSSSLGELMSRIRSATDSPLAVGFGVSTREHFIEVGALSEGVVIGSKLVQCLKESEATTEARAKAAFEFCDGITGKSQGGLPRAKPLVVKPPMSTHVAPASSVAKEARFGDFGGQFIPEALVQCHRELEQAYNAVRTDPTFWKEYRDQFNYIGRPSELYLAKRLSEWAGGAQIWLKREDLNHTGSHKINNAIGQVLLAKRLGKTRIIAETGAGQHGVATATACAKFGLECVVYMGAEDVRRQSLNAFRIRMLGAKLIAVESGSKTLKDAINEANRDWVSNIHNTHYLVGSAIGPHPFPTLVRDLQSVIGEETKKQLQEQAGCLPNAVLACVGGGSNAIGMFHPFVNDESVRLIGVEAGGQGVDTPYHSATLAAGKVGVLHGVRTYLLQDKDGQVIETHSISAGLDYPGVGPEHAYLKDKGRAEYMVATDSQALLGFKWLTEQEGIIPALETSHALYQAVMLAKTMQPEQHIVVSLSGRGDKDVEQVADGLSKQGWGDAIEWSLPSLIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRQ5</accession>
    <name>A8PRQ5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732330.1">
        <property type="nucleotide sequence ID" value="XM_001732278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRQ5"/>
    <dbReference type="GeneID" id="5856636"/>
    <dbReference type="KEGG" id="mgl:MGL_0105"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0105"/>
    <dbReference type="InParanoid" id="A8PRQ5"/>
    <dbReference type="OMA" id="ADEQMYG"/>
    <dbReference type="OrthoDB" id="2547857at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="638" mass="71770" checksum="6673C8FC8CC1BE99" modified="2008-01-15" version="1">MRQRFVYLLLKRAERIDTTFSIDECPRQCYEQVATLVHVAGNAHTLDGDLAGRLVFRLARMHALGALLPILNTYVTRSDTPVDPISAGQPLAAVLDESLTWFSKTAPDDPTKQTALALGIEALRLAFLRNWPIKHTLVQRWLSCAGPSLTKTCLNAPTSPKLPPQITVSMQGANDIDGILRDACAHRPQYMHERAVVVLSKLGDPRPAIDLLLSSSTCHSSLAPLPFDAYAAIISALTWMVRSNISRQAAMTLAVYVLDRLLQAGLRADEQMYGELIRALQCMLVPTSSRTSEVGSAWLKEYQAKLHHIEWHAYLAHFTTQMLARDDVGVIRIDHLRLLLRMHIQSRQFRMSRWLYEQIRDAYPDALPCSIPTMFSWLFLRAYSRPSSLSFAMRMYQDWLAFGHALPCAQIEPYLCALLSHGMASMAQRVIHDQCQLGRLPRPTLTVLVVRAYFVCGYFDAALAWASDLLALPDTTTPVTDSAHPAIPSLEYYAICLSEAGRCDQYGMDQHALLKLHRLFEEFQLGLAHAMTSDQVCLHTVTRAYYGMIQVLLKALEGETETSTLHDRTTHSNTTDQSHAIYKRIEMLWHEWDDLFGTLSDGHSALALRDDMKTLLTKMEKFVPRPSAAQIDQERKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRV1</accession>
    <name>A8PRV1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endomembrane system</location>
            <topology evidence="4">Lipid-anchor</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732359.1">
        <property type="nucleotide sequence ID" value="XM_001732307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRV1"/>
    <dbReference type="STRING" id="425265.A8PRV1"/>
    <dbReference type="GeneID" id="5856665"/>
    <dbReference type="KEGG" id="mgl:MGL_0134"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0134"/>
    <dbReference type="InParanoid" id="A8PRV1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="123" mass="13047" checksum="3B33AB45C40535F5" modified="2008-01-15" version="1">MSAIGTKTSSNTQTMVHVKSWSATSVTGTKSVYVRLFWRVSGANSQVITTEQGQELANELGMSYIETSAKSNTNVDEAFFRLAQQVKDHLVDQGITSNVPGASGTQNINAAGISNTQNKGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRX9</accession>
    <name>A8PRX9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732377.1">
        <property type="nucleotide sequence ID" value="XM_001732325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRX9"/>
    <dbReference type="STRING" id="425265.A8PRX9"/>
    <dbReference type="GeneID" id="5856683"/>
    <dbReference type="KEGG" id="mgl:MGL_0152"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0152"/>
    <dbReference type="InParanoid" id="A8PRX9"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005335376" description="Cyclin N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16204" checksum="EE829BE5B8CD2B0B" modified="2008-01-15" version="1">MRSASPLLCGRRMFLAAIVVASKFLQDRTYSNRTWSKISGLGTQEIDQLERVFLKMIRYDLVVNHAQWMKWTAELSSPHVKSSCITASTGQSAVNPTIFSPPRLHRVTSENVIGQALQFDSLLNEPQHNMGRGKRAFLRHGSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS77</accession>
    <name>A8PS77_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732433.1">
        <property type="nucleotide sequence ID" value="XM_001732381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS77"/>
    <dbReference type="STRING" id="425265.A8PS77"/>
    <dbReference type="GeneID" id="5856739"/>
    <dbReference type="KEGG" id="mgl:MGL_0208"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0208"/>
    <dbReference type="InParanoid" id="A8PS77"/>
    <dbReference type="OMA" id="VSICFRC"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042246">
        <property type="entry name" value="ZCCHC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 ZCCHC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="200" mass="22090" checksum="E75ECB2A1C0335C4" modified="2008-01-15" version="1">MHSPDPDQRSEFRRAKRAEERKNKMRCFVCRAFSHAAKDCPHNVSGDTQGKDTVGICFRCGSTEHSLAQCRRPRSEQADELPFATCYICSEKGHLASKCPQNKGKSVYPDGGECKVCGSVEHLARDCPRDPRRITHASHVEAGGVGLLDNVSSGGADEDEFHVVAQHRLNQQKDAQREWKKLHTSSSTPTGAASAKVVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSF1</accession>
    <name>A8PSF1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732471.1">
        <property type="nucleotide sequence ID" value="XM_001732419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSF1"/>
    <dbReference type="FunCoup" id="A8PSF1">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSF1"/>
    <dbReference type="GeneID" id="5856777"/>
    <dbReference type="KEGG" id="mgl:MGL_0246"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0246"/>
    <dbReference type="InParanoid" id="A8PSF1"/>
    <dbReference type="OMA" id="SSPNMKF"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1046" mass="119401" checksum="390DC0972B879B0B" modified="2008-01-15" version="1">MQEYSDAEGSDWDASDSSAFDEYEPSEDDAEDDENIENSTTAARQERNDEEEILTDIGQEDFSRLISAFQDEPITHEEEILSQRGKGNAWKQSMEADMESFHHELRDVNGYTRKNKSTRIREQALSPEVKALIAQANISAWYTLGMCFEELGEEEKSIQCRIVGAHLTSNASEEWRSLARRSRERGLLQQSIYCLQQVIKANRFDIDALWDRAMMLKDSGRLRVAADAFHGILKLRPYDAEILQELIPLLVSLGDYEIGADILEDMRRTSMRGAQDPNIDPALADMESTTGANVIFSLNELVTLADLLLLLKRPLQVILVVKQTIRWMRGQIREDRLDDAQNDLELDEVPAANAGDTSAHLQAYELDREVRLRLGKARFMLRDFEEGKRHFSLLIDETDPMEFPLLFLEMADTYFEYQLYAEALETYRPLLEEGLVDDVQVWIHMGMCYQNLNMLEEAAQVFEMILAEQAHQSDVKLSLAEIYEELGERNKALDLVNEVLAARHENKNNDHTHEAAPGPNQRPIEPPSSLSFFNESELPPGSAQASTQQRVSRSGITYAERQRLEQQREEETRLAWIQLCALEPEVFVDGFWRHDFVFLDGLDNEPSSSSISGPVDAATKQRFTATRKWIQVAGRLIDSFRSMSLLFPKERHTKYRGVVRPRRSRQSKALDLDTQAEELLNRLRDQMVDEAMSDEAAGTQTSTNAAENFARDHNEQEQTTFRTIHFDDWVTLFMKYGIALAKVGNEDEAVNDMFRHVMVSNTVWPSEERKLSLHLCWLACALYSRDFARAFEIARWLPTTYQFHNEPLRLITSLANSLGFYGVDAFVSSTNTKQYQRRMRTHEAIIMGRPAKVNPRTGRWTMVGVDDDDEKGAAGTDEYSNTTKAQVPPTKSSPIGEIFYGYLMLCANSFQPAMGYLYRALALQQNDPLLCLLCCAATLGRATNRQVDNRNHTVIQGMSMLANYAELRGQSLEVDYNFGRAYQHLGLVHIAVPRYERVLQRAQQASSAPLRGFDMIRETAFNLAMIYNQSGSPDLARQLYRTWLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSP7</accession>
    <name>A8PSP7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732520.1">
        <property type="nucleotide sequence ID" value="XM_001732468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSP7"/>
    <dbReference type="STRING" id="425265.A8PSP7"/>
    <dbReference type="GeneID" id="5856826"/>
    <dbReference type="KEGG" id="mgl:MGL_0295"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0295"/>
    <dbReference type="InParanoid" id="A8PSP7"/>
    <dbReference type="OMA" id="HFEMIAT"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="216"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="505"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="833"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="953"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1001" mass="107720" checksum="52672E734C7BACC7" modified="2008-01-15" version="1">MVLQVETTSTNSQGQIMPSSYGGSSDVSMPSSQPPSQVSSRAPSPPLSLQSGVVKPAAPIRTVPSTSSMSRSDGAPEMVMMISSAPTPSPMVLHPPRTSLLLPSSKSSVSNSHDLESIHSPWLIDGSALQRVSSPELDTDISRTSSTSTKNSVAMAGSPKSSSESVHTAHSGSQSSTAESAKSAEIIKADTESDHANDEGEVTAEVDSTDTRHRLKRLHSLLELAETEANYVKDLDVLINVFFKLLPGVPYFADSSSRLNTVVRNGPALLKLHRNMSSRLTDIVSCKRLASSDSERTEMERAHSPDCDEAVSLYAKLFIELAPEFSRVYCEFCSRQKEALSLIDTVEQRPEWDLYQYRASDTVRSLGSCEDIQDSASQAAMRAKSRQRLLFRDFFIKPIQRVCLYPIILQTIRAYSTPAHQALLDDALRHMRQVTADVNEASAKRQARLLSEMIISRMEPSLSLSSSFLPSLGDCKMTGNLDVLYHHPELAPLTTPLATKYYGCVLYADFVLMFKARKTYTYQPRYWFPLADVKLTPSTDPTVKLPLSFRLTIHGHHFEMIATTEKERDLWLDAFAKAISEGPAPQRRLHGMDVPFPCNLEPVPPSASSSTSTSVSSSSSSVTPSAVDPLARYLGTCTLNDGSDGRSCASQPSTEVLMRLKSPPRRAAKDKVMVFSDACISARSSIDIDSTRSRGMLVGSRVGLHRLSGNETLSLRLSTNDLPPSTSALTSSQDSTSVLTTESPLDSSRPQSLSSPQSSKGLDSADHKASRPSRSETDPVRSRSPEAPTRQVMPRSQSMLGRTLQELLAPTSLSVPAKAEDLTKALMDAFTPSSASSSASAPVSLSSGSKLKRSSSLDLSGSPTPLGSAASMGPASAVAPSAPSLSSSTSSTSSMPATSFIPLSSSASSAGSGSSSLSTISGSASSEMSMRHHRSRCSSMDRTSSKTTHRRSSSSLSSLPFRSNSNDSTPTTTSPNASRSLSPRRRLAQRFLQRNRFSSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PST1</accession>
    <name>A8PST1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0311</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732536.1">
        <property type="nucleotide sequence ID" value="XM_001732484.1"/>
    </dbReference>
    <dbReference type="SMR" id="A8PST1"/>
    <dbReference type="FunCoup" id="A8PST1">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PST1"/>
    <dbReference type="GeneID" id="5856842"/>
    <dbReference type="KEGG" id="mgl:MGL_0311"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0311"/>
    <dbReference type="InParanoid" id="A8PST1"/>
    <dbReference type="OMA" id="IKHCEYM"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="604"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1214"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1264"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="12">
        <location>
            <begin position="219"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP45322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1311" mass="149973" checksum="4B06D4D9D0F4A463" modified="2008-01-15" version="1">MDPRMQGGAATQPVHQNPFYSSGPSSPQGQDPAIDGHGSPFSPSSPNGGGMPMSQSGYAAQLSSFAYQEAAASGVRQREPYPAWTVDKQIPLSKEEIEDIFIDLANKFGFQRDNMRNMYDHLMILLDSRASRMSPQQALLTLHADYIGGEHANYRKWYFAAQLDLDDAIGKIQNPGLARAASMAQRSGAPKRGSAFLGTKSLENARARWRDAMYRMSDYDRIRQLALYLMCWGEGSQVRFVPECLCFIFKCADDYYRSPECQNRLDPVPEGLYLHSVVKPLYTFLRDQVFEIIDGKFVKKERDHDRIIGYDDVNQLFWYPEGISRIKLTNGMRLVDVPPQQRYMKFDKIDWRKAFFKTYRESRSFLHLLVNFNRIWIFHVALYWYFMAYNAPKAYEPHRSPTDAQMLSASALGGAVSTFFMICATVVEVIYIPTTWNNTNHLIGRLIVLGICMALMIAPSVYIFGFNRDNHIAYALSVAQMVVSSILTTIFAILPTGYLFGDRVSWRRRKYMASQTFTASYARLPWTRRFFSILLWVLVFGCKLTESYFFLSLSFKDPFGVLVTMRVKPCHDRYFGTVLCSLQPTFALSAMMVMDLCLFFLDTFLWYVVWSTVFSLGWAFYLGLSVWTPWSDIFQRLPKRIYSKLLATADMEIKYKPKVLVSQVWNAIIISMYREHLLSIDHVQRLLYHQAPAENSPHKRTLRAPPFFLNQLESGSKPEFFPKGSEAERRISFFAQSLMTSIPEPLPVDAMPTFSVLTPHYSEKILLSLREIIREEDQNTRVTLLEYLKQLHPVEWDNFVKDTKILAEESGNFAGGAPFGFEDEKSNLKGGKSDDLPFYCIGFKSAAPEYTLRTRIWSSLRAQTLYRTVSGFMNYNKAIKLLYRVENPEIVQLFGGNTERLERELERMSRRKFKFVISMQRYSRFNKEEIENTEFLLRAYPDLLIAYLDEEPPSKEGGESRWFSALVDGHCEPLPNGRRRPKFRIELPGNPILGDGKSDNQNHAIIFHRGEFLQLIDANQDNYLEECLKIRNVLSEFETIDMPTENPYGPGYHVFDEAPVAIVGSKEYIFSENIGILGDVAAGKEQTFGTLAARGMAQIGGKFHYGHPDFLNSVYMTTRGGVSKAQKGLHLNEDIYAGMMVFQRGGRIKHSEYYQCGKGRDLGFGTILNFITKLGNGMGEQILSREYYYLGTQLPVDRFLTFYYGHPGFHINNIMVILAVQLFMFALMFIGSLYSTVDVCPDTDGIPFVLGSGQCYYLNPVVYWVQRTVISILLVFMIAFLPLFLQELSERGGYLCVCPSLEAVCVDESSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSU5</accession>
    <name>A8PSU5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732543.1">
        <property type="nucleotide sequence ID" value="XM_001732491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSU5"/>
    <dbReference type="FunCoup" id="A8PSU5">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="GeneID" id="5856849"/>
    <dbReference type="KEGG" id="mgl:MGL_0318"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0318"/>
    <dbReference type="InParanoid" id="A8PSU5"/>
    <dbReference type="OMA" id="NDRLEWI"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="450" mass="50052" checksum="04309D3C3EA346A8" modified="2008-01-15" version="1">MLGLSRESISNVTGTASLLVWIFAQSPQIYKNFRTKSVDGLSFVFLFQWTMGDLTNLVGAFLTRQLPIQIVIAAYMLVIDVSLCIQYGLYYQRPEKIQRVSGFSAERSPLISGPSRHARAMSRVHYKSRGHSLDPWLVYRVKPHRTAKRSYGYGSTHLQPENLPIDTNSRKAATSLDRGRNRATRHIRGYMSRSNTLQAPSRVGLDAGSLDISGKMRREHGRSTNGLRRGSVMAMLSVGMLVSLGPINMHLRQNAPPFVSSTSLMAAPTVVAAQKGIPPPWDLFSGAVNISSSPISAAPTTATTAVPLPAPRYPILLYMPDMMLFRRRRRQPHEPPLPLSVVIGRISAWLCTLLYMTSRLPQIWTNFRRKSVRGLSMLLFLLAFIANLLYSISIVSNPKAVGPGSYDYLLESLPFLLGSSGTLIFDVVILAQYAMWYERPVPKARSTMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTG1</accession>
    <name>A8PTG1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase delta subunit OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732644.1">
        <property type="nucleotide sequence ID" value="XM_001732592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTG1"/>
    <dbReference type="STRING" id="425265.A8PTG1"/>
    <dbReference type="GeneID" id="5856950"/>
    <dbReference type="KEGG" id="mgl:MGL_0419"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0419"/>
    <dbReference type="InParanoid" id="A8PTG1"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="3">
        <location>
            <begin position="30"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="218" mass="24206" checksum="F5BC29D9979DF709" modified="2008-01-15" version="1">MERARASFDALASLSDPLRVPASERTYGRQFAQMYDYRLAVLRRRAREAAMAQRPDTCVNATYIERLLDIPPRQMCMVVGTFYSAMQLKPDVLQDIARDLSLPAPPPRTSYVDTEHDELFLEDQSGRVRVVGDLLRPGTQLAQTCVTGVVACVIGIETPDGDLEVHHVFFPGLPPTAAVSYLAAKQLPRPRTITTSSFLQVVCTWESRIHAVISLGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTY8</accession>
    <name>A8PTY8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MGL_0500</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732725.1">
        <property type="nucleotide sequence ID" value="XM_001732673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTY8"/>
    <dbReference type="FunCoup" id="A8PTY8">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTY8"/>
    <dbReference type="GeneID" id="5857031"/>
    <dbReference type="KEGG" id="mgl:MGL_0500"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0500"/>
    <dbReference type="InParanoid" id="A8PTY8"/>
    <dbReference type="OMA" id="TYERVTT"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059098">
        <property type="entry name" value="WHD_MCM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23669">
        <property type="entry name" value="WHD_MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="495"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP45511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="930" mass="104474" checksum="EF1FA6EE6F5D022F" modified="2008-01-15" version="1">MSSDPGTSHRKRRRSTSQGPLDPSSPWPDSGASESGQGDRASVTAASSMPTSSPPGALSDFTDDMDSHSMLDQVDDDPDDLVNGAENEDDGEDLFDDTMMADYRANPELDTYEAVGLDEADFEHMDATTRQLAELRMARRDRAEGVGRMSRRAPVFLQSDDESEDDVLRQRRRRRHYDEVQEEDAAEVDELPIEQLSDIKADSIASWVATENVRRTIVREFRNFLVTYVDEQGVSVYGQRIKTLGEMNLESLEVSFLHLVDAKAILAFFLANSPASILPIFDEVAFDVICLYYPSYDRIHPEIHVRIADLPTSSTLRDLRQSHLNSLVRVSGVVTRRSGVFPQLKYVKFDCLSCGEVLGPFWQDSNQEVKISYCSNCSRRGPFRVNSEQTVYRNYQKMTLQESPGSVPPGRLPRHREVILLWDLVDSVKPGEEVEVTGIYRNNFDAALNTRHGFPVFATVLEANHIAKRDDAYAAFRLTEDDEQEIRALARDDRIGKRIIKSIAPSIYGHQGIKTAIALSLFGGVSKDVGGKHRIRGDINVLLLGDPGTAKSQFLKYVEKTANRAVFATGQGASAVGLTAGVRRDPVTREWTLEGGALVLADKGVCLIDEFDKMNDADRTSIHEAMEQQSISISKAGIVATLQARCAIIAAANPVRGRYNPTIPFSQNVELTEPILSRFDVLCVVKDIVDPVQDEMLARFVVSSHLRAHPLFDEDVDETRAATSMDADIIPQDLLRKYITYARDHVRPRLDTLDQERLSRLYADLRRESLNTGSYPITVRHLESMIRMAEASAKMHLRDYVRADDIDVAIRTTVESFVQAQKISIKRTLERGFRKYIHQARDHDELLAFLLGGIVKDKMRFTHYRHHHAMRSETGPTVISVPLAELEARAKSVEIYDVRPFMLSRVFRTNGYQWNEALGTITKQFGTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU04</accession>
    <name>A8PU04_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAF17 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732732.1">
        <property type="nucleotide sequence ID" value="XM_001732680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU04"/>
    <dbReference type="FunCoup" id="A8PU04">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PU04"/>
    <dbReference type="GeneID" id="5857038"/>
    <dbReference type="KEGG" id="mgl:MGL_0507"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0507"/>
    <dbReference type="InParanoid" id="A8PU04"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="5">
        <location>
            <begin position="165"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="289" mass="32410" checksum="0DE754BD372D4851" modified="2008-01-15" version="1">MADAFLHLIPYAREPSILVEVDKCISTDLIAFVKRFKLRSKFQINDVSDAWDVMQLYGNAQVDLDMLNLYGAYAFRDVRSPEMGWRVLLPKKHTEQEIPLKNATDVDYTIHRMLQGVPEGSKEIHMGSSLPLESCIDYMHGVDFRKGCYIGQELTARTFFTGLVRKRIMPISLDPNPCHHSSPAPINVDTSMNLALPDSGADVRFVMPQKSDVSTSQPGRSRSAGKFLSGIHNIGLALLRLEQVDKSNSEEAGHPRLVLEAPDGSPLYLHAYRPSWWDSETLQKPNGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU17</accession>
    <name>A8PU17_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732739.1">
        <property type="nucleotide sequence ID" value="XM_001732687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU17"/>
    <dbReference type="GeneID" id="5857045"/>
    <dbReference type="KEGG" id="mgl:MGL_0514"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0514"/>
    <dbReference type="InParanoid" id="A8PU17"/>
    <dbReference type="OMA" id="CQGEDLG"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="158" mass="13685" checksum="D030909AEAC991DA" modified="2008-01-15" version="1">MSSGQGGGLGGMLGSVLGGGKHSGGMGSQGGSGKMLNNLIGNFVGGGRYGGGSMGGSSTSGGMGSGMGSGMGGGMGGHHMGGGSMGSGMGSGMGGGMGGHHMGGGSMGSGMGGGYMGGGGMGSGMGGGMGGHHMGGGSMGSGMGGGYMGGSGMGGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU26</accession>
    <name>A8PU26_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732747.1">
        <property type="nucleotide sequence ID" value="XM_001732695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU26"/>
    <dbReference type="FunCoup" id="A8PU26">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PU26"/>
    <dbReference type="GeneID" id="5857053"/>
    <dbReference type="KEGG" id="mgl:MGL_0522"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0522"/>
    <dbReference type="InParanoid" id="A8PU26"/>
    <dbReference type="OMA" id="HIFAEMA"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="136" mass="15254" checksum="22528F69550CC669" modified="2008-01-15" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPTAGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDIALARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUC6</accession>
    <name>A8PUC6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732061.1">
        <property type="nucleotide sequence ID" value="XM_001732009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUC6"/>
    <dbReference type="FunCoup" id="A8PUC6">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUC6"/>
    <dbReference type="GeneID" id="5856357"/>
    <dbReference type="KEGG" id="mgl:MGL_0654"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0654"/>
    <dbReference type="InParanoid" id="A8PUC6"/>
    <dbReference type="OMA" id="KEQWLFK"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="12"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="258" mass="27916" checksum="8D235044072F3D6F" modified="2008-01-15" version="1">MTTVDLGTVFKGSPSGRLIETKGGSRTLRANDVVIDIAYSGVCGTDLHYRKADMVLGHEGVGVVSQVGPEVKAVKVGDRVGWGYNHKSCGYCNECWDGFDTLCPERTMYGVADLDIGSFGDRAVIDADYVHKIPDAIDLRDAGPFQCGGATVYSAMVHSGIQPNQRVGVLGLGGLGHLAVQYLAKMGCDVVVFSGTNSKREQAMQLGAHEFVASKENPKFENVKPIRHLLVTTSFQPDWPLYFNIMEPNGHIVPLTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUE9</accession>
    <name>A8PUE9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="14">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PIF1</name>
        <name evidence="16" type="ORF">MGL_0671</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="14"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732078.1">
        <property type="nucleotide sequence ID" value="XM_001732026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUE9"/>
    <dbReference type="FunCoup" id="A8PUE9">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUE9"/>
    <dbReference type="GeneID" id="5856384"/>
    <dbReference type="KEGG" id="mgl:MGL_0671"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0671"/>
    <dbReference type="InParanoid" id="A8PUE9"/>
    <dbReference type="OMA" id="SSAWESC"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001226">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="98"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="14">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP44864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="546" mass="61127" checksum="6BBEEFD6F4F4FF22" modified="2008-01-15" version="1">MSQTEKERTEDDDFLPFEPLKSNNTCVGATAKRAATTSSSHTSSNLNALIKPLIRSREKPFPAPAHVASVQRPPEKRSAARVFLSREQQSVLEAVVKQEKSVFFTGSAGAGKSYLLRQIIQDLHVKYSKSPGAVAITASTGIAACNIGGITLHSFSGVGVGTGTPDQLVRTVRRNRPTVTRWKKTAVLVIDEVSMIDPKLFEKLDHVARVIRQSNRPFGGIQVVMSGDFFQLPPVSPNGQTSFVFESPVWSSVIQQKFNLTEVFRQRDQTFVNMLNDMRYGKLAPETIRIFSQLERTPSLPEGITPTELYALRRDVEKANQMRLDALQTDMRTYTSMDSGQLPPDQLQRTLDNFMAPRHMALKKGAQVMLIKNVDRELSNGSVGTVLDFLDEDSFKDQYGEEDVSDELLARAERAPGASRTMQQERTEARAAPRWPLIRFHLVNGHVRDYLARPESWKMEDPNGKVVASRTQVPVILAWAMSIHKSQGQTLQHCRIDLRRVFEKGQAYVALSRATSLDGLQVIGFHPSKVMAHPKVIQWNCREFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUM6</accession>
    <name>A8PUM6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732126.1">
        <property type="nucleotide sequence ID" value="XM_001732074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUM6"/>
    <dbReference type="GeneID" id="5856432"/>
    <dbReference type="KEGG" id="mgl:MGL_0719"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0719"/>
    <dbReference type="InParanoid" id="A8PUM6"/>
    <dbReference type="OMA" id="ACVANEH"/>
    <dbReference type="OrthoDB" id="3343201at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027850">
        <property type="entry name" value="DUF4504"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31366">
        <property type="entry name" value="UPF0739 PROTEIN C1ORF74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31366:SF2">
        <property type="entry name" value="UPF0739 PROTEIN C1ORF74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="253" mass="28682" checksum="FC91811CF4EAC470" modified="2008-01-15" version="1">MLIDTCTLSLRQIQALAALFEQHGLDNLSLILYAPAHQVFVVNRQSVIESFEKDQNRRVFVDPRYAHQPVYDTPAGVQTILSRIQEACVANEHASIIVSRNSTEDARYLGISACGWLLGYPVVYLCSTVGDALDISHMDASIQCLPVAHEEADAHWSTNEWDTSAAKFTDLSLLLVEATMQYAPVPQMSAHEYHPVMAYTLPVNMPHAQELVDAWKHQILSHWQARRVYLPEFLRHVTFHIQSVQIYMDRIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUQ5</accession>
    <name>A8PUQ5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732153.1">
        <property type="nucleotide sequence ID" value="XM_001732101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUQ5"/>
    <dbReference type="STRING" id="425265.A8PUQ5"/>
    <dbReference type="GeneID" id="5856459"/>
    <dbReference type="KEGG" id="mgl:MGL_0746"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0746"/>
    <dbReference type="InParanoid" id="A8PUQ5"/>
    <dbReference type="OMA" id="VTWPAFV"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="644"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="538"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="920" mass="105237" checksum="D46C90992EF9A211" modified="2008-01-15" version="1">MFTQTWIMTTPISQITYRNFSDLFFPLFIPAVLSIFANLMIPRTAYRTYFRCMSSALDAITGLMEISMTNFEKELVEWQKFVSQNPDNYYDAHAFEQSNNVSSSLKVLKERVSVMNRALSASLHEVTWCIIPISETNHLRTFIVDTSTWLKSGMGLSIPQVDFEDPLFDETRDAEDDEVISMAESTTSLRMTLSNPQSMSVLQMNKIEEVARSLRDLESAILDVIGLLKVLINNSIHNFSQTYPRSSSVTFAKAIHHARLGDSEKFGNPMEILSNTEKELENAMTKCNMHLHLLLRARGFRESHENQAPTPPASVNSSSDPTKKSDEEAKSTQDQFRKPNLFCTDMYVVCQFYLSLFQLARRAKNTLNLSVPMLEKLVKRRRRSIYLPRFDFLRWIQSTSGISLFQNATTDLYLPSHYANRGQVGTTDDNNDEHSDNIAHIFENPNKKTKYKTYAQNVAHAMRTTRKNVRGNTLWSHFRYRVISILRSSPVMNGRIFISTVLQQVKHSSHVRFALKLASGVTLFSAIGFVYPRQDQWWRQCKGPWLLIAYTWSLEATTGDSFRIAIFRIIGTILGSLFGFLTMEISRGNPWGISVMISFFSVIAILIRMRPSLVPVGALTGFTTPLVAILAYQSPRGDAPIHEALLRGYMNLLGIAAALVVNLVFWPYHARTQLMYKLSDTSTLLQNWYLTMARQMLYRGFKSSPKLQAGYIELEKSIRLHLTSCEALMRVISSELSLVPKPIKIMHRIFEHLEMIFTLFMTLRMCREQEYRTGSELAVLQVLHLRQELISSVVLDLWLVAQSMITRARLPQSLPSTKRSMEEGISATALGYHELVYYNSPNNISSQRPIYDGPFLRQEAYPKLSSTSSYGERGYASHTRTMEDTMFLLAEHSILSQIVFSLECLLQLMRFMLGELRLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVF9</accession>
    <name>A8PVF9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731584.1">
        <property type="nucleotide sequence ID" value="XM_001731532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVF9"/>
    <dbReference type="FunCoup" id="A8PVF9">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVF9"/>
    <dbReference type="GeneID" id="5855890"/>
    <dbReference type="KEGG" id="mgl:MGL_0852"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0852"/>
    <dbReference type="InParanoid" id="A8PVF9"/>
    <dbReference type="OMA" id="ENHEITH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006521992" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="200" mass="22036" checksum="8368642C7ED2D3E8" modified="2008-01-15" version="1">MQFSLVRFLVAFLVSVSLVLALKTSEAKVTHKVYFDIEHGDKSVGRVVMGLYGEVVPKTVENFVGLAEREEGRGFKGSIFHRVIKGFMIQGGDYTRGDGRGGMSIWGKRFDDENFKLKHEGAGILSMANAGSDTNGSQFFITVAKTPWLDGRHVVFGRVLEGMDVVNYVENVRTGPGDRPVDEVRIFDAGLLPDGPHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVG8</accession>
    <name>A8PVG8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731593.1">
        <property type="nucleotide sequence ID" value="XM_001731541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVG8"/>
    <dbReference type="STRING" id="425265.A8PVG8"/>
    <dbReference type="GeneID" id="5855899"/>
    <dbReference type="KEGG" id="mgl:MGL_0861"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0861"/>
    <dbReference type="InParanoid" id="A8PVG8"/>
    <dbReference type="OMA" id="IHGFEFA"/>
    <dbReference type="OrthoDB" id="3345971at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="660" mass="72817" checksum="57F46EB65FAA7273" modified="2008-01-15" version="1">MPSQDQVLAGVVEIECPSDRAIDKLEIRLCGMQKIAIPEKVNEKSNQGPLSVRYEDHVVLDRTLTYTSENLPTHSARTARGHAPFLSRITETDSDTAIFLERGVHDFEFHFIIPAWCPPFERCRYAHTHYTITAMVDGAGLGRLGAPVSASREVVLVQQQTLDNGPLQLDMLYDDVHPALGYMTIAVTSASLTVGGIVHLYVVHPNPPPNLNVLAINVIIEQKYELYNKATGEWMPVPTDTLRVWDLGIPAPRTREMNNAKHWAQGLLTAEGVQQGTASRIGMIGRAARSFLTPMDAQAQEGITDLHGYQIKTVLRLPNDRKLRPSTMQGTRTNIRISHELGVDVLFSLTDNLEDRKNNEMYGLPKTQVFSMVKKVRIPSCECTFDAIHLPPYSEESPSIATEGTTLSRSSSSHSLLCPPATIQRSMSSASRSSSTHSMLQPPTPFFKQHRQHGPLDNDWSRLMSSLTSLSTRSHAPSRNASLESSPTRPNFFSRNSSSNASRVPSPPLDSSSGYSTPVVPVLRPNDTCLQSTQADSQLQHTRSLSSTDRSAPRALLAGSPWAVSHLPPRTGESHDTCNCGLQTEELIEAEERLLEGAPTAPGAWIQRVKVNEALPPWTPSTRPKSPTHNWYETYMHGKTPFSNKSESSMASQRSASTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVI4</accession>
    <name>A8PVI4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aprataxin C2HE/C2H2/C2HC zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731609.1">
        <property type="nucleotide sequence ID" value="XM_001731557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVI4"/>
    <dbReference type="STRING" id="425265.A8PVI4"/>
    <dbReference type="GeneID" id="5855915"/>
    <dbReference type="KEGG" id="mgl:MGL_0877"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0877"/>
    <dbReference type="InParanoid" id="A8PVI4"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22463" checksum="5B39A973CA24D3CA" modified="2008-01-15" version="1">MPPDMLVDHDPYTYTICDGYAKAQYHFLILPRIPFYIDVQDQGISTRVQVPTRDLDSIQALLQSRHASAVLDRLGEARHRLVHRIHASMRQARIEPHGHYAFYPCSDDKDQHAEGVAWHVHCGFHSVPSMRHLHLHVISNDLVSNRLKHKKVSCIGSTHMLMHCSLLQHYLSFHPAVGFSLPLEKAQALAAQGVSKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVL9</accession>
    <name>A8PVL9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-coenzyme A transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731636.1">
        <property type="nucleotide sequence ID" value="XM_001731584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVL9"/>
    <dbReference type="FunCoup" id="A8PVL9">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVL9"/>
    <dbReference type="GeneID" id="5855942"/>
    <dbReference type="KEGG" id="mgl:MGL_0904"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0904"/>
    <dbReference type="InParanoid" id="A8PVL9"/>
    <dbReference type="OMA" id="RRKSWIM"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60569" checksum="F916137B7F5D0DAB" modified="2008-01-15" version="1">MGRAEQKADVLVKDQSPGDVKNEVSSRPEDAHSFRLLSAEDKHGFMLLVLLYMLQGIPVGLAFGTMPFLLKSYVGYSQLGIFMLSTYPYSLKLLWSPIVDSLFVSAWRIPCTKLELSLGRRKSWIVPIQLIVGITFLVISYQIDALLENAETSIYLITLVFFGLIVLAATQDIAVDGWALTLLSEENVGFASTAQTIGINVGYFMSFTVFLALNSVEACNKYLRFRPQSTPILTFPAYLQLCAAAFILITLWLLFFQKEKKEENNMDIVKAYATIWKIGKLRHVQLLLIIHMICKIGYQANDAVTGLKLVERGLGKEDLAFAVLIDFPFQLLFGYLTATWSKGNKALRPWMISLFFRLFFSVVNMGIVAGMPQDGSEVSTSYFLLIVLTTVLNSFAGTVQFVGVSAFHTQISDPIIGGTYMTLLNTVSNLGGTWPRYFVLKMVDYFGVSMCRPPVGVDMDKVENVLGQANASLSLGECKSDAGMKQCQSVGGSCVLVRDGYFATSTICVTVGLCTLLLFIMPVCRYLQRIPPAEWHVVSQNQKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVT9</accession>
    <name>A8PVT9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0954</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731686.1">
        <property type="nucleotide sequence ID" value="XM_001731634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVT9"/>
    <dbReference type="FunCoup" id="A8PVT9">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVT9"/>
    <dbReference type="GeneID" id="5855991"/>
    <dbReference type="KEGG" id="mgl:MGL_0954"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0954"/>
    <dbReference type="InParanoid" id="A8PVT9"/>
    <dbReference type="OMA" id="DIAMHAR"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF541">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="508" mass="55729" checksum="5176EB02E0232291" modified="2008-01-15" version="1">MITEKRRYLLPPEPYVADPNFADGRPLPESSAYACARFEMDALIKSVFDQILDAVEQCHSLGIYHRDLKPENILCADGGTRVMLADFGLATGDRMSSDFGCGSSFYMSPECQGSITNRMSQYSTAANDVWSLGVILINLICGRNPWKQATPTDETFREYLRDPDFLGKILPISNEVHAILKCVFALRPESRCSVRDLRRWIRAVPRLQASNWEMWQRHHYDTLALQPRSVDGPPCGSQDSTLMGTSPTLFDPDVPQFSTLSLRSPVVSSLVSPTALEPSKVKQAPVNATALRTPFSLPKEDTDSSALACQVPPIVSVSPQITSSPASPGVARGTTIPDTGAGPHVSSYRSTPKDFRITSRQPLLTLPKAEEPLSFAFEPDPEERSTPPSSVSQADKLMEQMSSVLSTTTATTTTTTTATATTTTTTTTTTTTSTTDPTQRRRPPSPRFQFDQKEHARSNTRASSHLPHAPNQQAHAWRSSAGFPSSGLSSYICARQFTPEIQWRALAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW83</accession>
    <name>A8PW83_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl-CoA thioesterase II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731777.1">
        <property type="nucleotide sequence ID" value="XM_001731725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW83"/>
    <dbReference type="STRING" id="425265.A8PW83"/>
    <dbReference type="GeneID" id="5856082"/>
    <dbReference type="KEGG" id="mgl:MGL_1045"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1045"/>
    <dbReference type="InParanoid" id="A8PW83"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025652">
        <property type="entry name" value="TesB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02551">
        <property type="entry name" value="Acyl_CoA_thio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase 2 C-terminal" evidence="3">
        <location>
            <begin position="199"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="35169" checksum="4147CE162FA74E57" modified="2008-01-15" version="1">MKDGITLTPEEWDERIPSFAGVRQTSFCEFESVAKEHFVPVMGKSVFGGSLIAQSMESASKTVPRHMELHGKFLDRANVNDYIHYFVKKLRDGRSYVSRRVDAMQGTTLLFTATMSFQMPEPDQPQFFAPPPKIVMDGDFKLQLNIQEGQNFLPKEVLAPEKCMLSYKRYEHLLSTIPKDDPMYAMCAKWTDDQRHVYPVEYRPAVPTMYDKNGHLQYGTSVAYWVRSRGNSPGSINFQRAMLAFQTDQLLLVNMQSSIRSLVPSMMASLDHTMWFHNDFTMKDWLLMVIQEGVFRYDTNPASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWD1</accession>
    <name>A8PWD1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731804.1">
        <property type="nucleotide sequence ID" value="XM_001731752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWD1"/>
    <dbReference type="STRING" id="425265.A8PWD1"/>
    <dbReference type="GeneID" id="5856109"/>
    <dbReference type="KEGG" id="mgl:MGL_1072"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1072"/>
    <dbReference type="InParanoid" id="A8PWD1"/>
    <dbReference type="OMA" id="FCDENYE"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="2">
        <location>
            <begin position="59"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="474" mass="52482" checksum="E5450A7E9CA00F90" modified="2008-01-15" version="1">MSGFHSTSALTQSADDSQTSLPIFSTNIRRGGSVVRAWDRLKHFCDENYEELRDTLNWPATQEQLAMLQHGIRQTLPQAVCEWLLCCDGQEVESLATCKDGLFFGLPFLGTDDILREWQFWRHVDKDAETGDNPQLRRHMRSCPPGRVRQEYSHPGWIPLVADGMGNYLGVDLSPDPRGDGKPGQVILFGRDFDTKMVLYGCDGPEGWANFLSLFVDELEKGTSFVLGDSNQEDSMEDDIGYESYFTGSGERAGEGTIRFRLAGKYARWPVLDSWFDKSALAWEVAGFSLPAHNEAHQNLADDIPDISTSSSTHDPLDPLQKTPNRSRKSSANNSPALPRDMSWPDGIGSGYMNSSSPVKRRVLPKPSPLTDLPTIEDVRAIQATELVQHAHNPTTFNGLRGKSKRNSAYINMSVPSTTVTIGENVEMSMRPTTGQSTAEEDVVPSSTIDMSGDVSQWKRSNALKSTSKLLDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWL3</accession>
    <name>A8PWL3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731872.1">
        <property type="nucleotide sequence ID" value="XM_001731820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWL3"/>
    <dbReference type="GeneID" id="5856177"/>
    <dbReference type="KEGG" id="mgl:MGL_1140"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1140"/>
    <dbReference type="InParanoid" id="A8PWL3"/>
    <dbReference type="OMA" id="GTHPENH"/>
    <dbReference type="OrthoDB" id="3357787at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="202" mass="22802" checksum="9B7770E2BC5AD77E" modified="2008-01-15" version="1">MLVIYGLVLFLYLTPLPTYLSGNHPKSHMTLYLNHHSIIGTEEDLTYLPAFPIYLVVTSFLVYVMYLAAYECATRANLIKLKGLPYPAQPHPFGSAPNWIVPVLRDIRVQPSSSVRADPTKQSTSIERAKTLPPQLVYIGFLWVCSWPVPLITFGVGAFDDAAWWAFSFVALSIHLVVEWWIYKAELDTFGLSGLKYNYKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWL6</accession>
    <name>A8PWL6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1143</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731875.1">
        <property type="nucleotide sequence ID" value="XM_001731823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWL6"/>
    <dbReference type="FunCoup" id="A8PWL6">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWL6"/>
    <dbReference type="GeneID" id="5856180"/>
    <dbReference type="KEGG" id="mgl:MGL_1143"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1143"/>
    <dbReference type="InParanoid" id="A8PWL6"/>
    <dbReference type="OMA" id="MGVMKPD"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="77"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="148" mass="14944" checksum="2099A3FB23AD5653" modified="2008-01-15" version="1">MGVTAAIVFTCLGASYGTAKSGVGISAMGVLRPDLLIRCIIPVVMAGIIAIYGLVVSVLISGDLKSPMTLYAGFIQLGAGLSVGLAGLAAGFAIGIVGDAGVRGTAQQPRLYIGMILILIFAEVLGLYGLIVALILNTRSQDAGSCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWT6</accession>
    <name>A8PWT6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1212</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3 12"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731944.1">
        <property type="nucleotide sequence ID" value="XM_001731892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWT6"/>
    <dbReference type="FunCoup" id="A8PWT6">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWT6"/>
    <dbReference type="GeneID" id="5856249"/>
    <dbReference type="KEGG" id="mgl:MGL_1212"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1212"/>
    <dbReference type="InParanoid" id="A8PWT6"/>
    <dbReference type="OMA" id="RKIHMLA"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="398" mass="44786" checksum="53D40741E72EEC36" modified="2008-01-15" version="1">MVQEDALTPHKRYELITRGIEEVIGGDLIQKILEENERPLKCYWGTAPTGRPHVGYLVPLTKLADFLRAGVQVKVLFADIHAFLDNMKAPIELVKHRAEYYRQILTCVMKSIGVPTDRLTFVLGSSYQLTEKYNFDVYRLAAMVTEHDAKKAGAEVVKQVASPLLSGLLYPGLQALDEQFLDVDFQFGGLDQRKIFMFAEQYLPKLGYMKRAHVMNGMVPGMNGSKMSSSDTDSKIDFLDSPSEVAKKIKAAYCMEGVVEENGVLAFVGAVLMPIARVRNEMMHKHTQLDGQSQSFIPEEAPEGTLFSIMRADKFGGPLHYASFDDLVRDFKEKKLHPADLKPAVSSALNKLLEPVQKMLANEEFKKLKALAYPEDEPKVKKVKEKKCAWKEVDSHIQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX35</accession>
    <name>LIP4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Secreted triacylglycerol lipase LIP4</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
            <ecNumber evidence="5">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LIP4</name>
        <name type="ORF">MGL_1311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Microbiology" volume="162" first="1069" last="1079">
            <title>Secreted lipases from Malassezia globosa: recombinant expression and determination of their substrate specificities.</title>
            <authorList>
                <person name="Sommer B."/>
                <person name="Overy D.P."/>
                <person name="Haltli B."/>
                <person name="Kerr R.G."/>
            </authorList>
            <dbReference type="PubMed" id="27130210"/>
            <dbReference type="DOI" id="10.1099/mic.0.000299"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Secreted lipase involved in Dandruff and seborrheic dermatitis (D/SD) probably via lipase-mediated breakdown of sebaceous lipids and release of irritating free fatty acids (PubMed:18000048). Has triacylglycerol lipase activity and is able to hydrolyze triolein (PubMed:27130210). Mostly converts monoolein to di- and triolein, while free fatty acids are only produced in low amounts (PubMed:27130210).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EC" id="3.1.1.3" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731128.1">
        <property type="nucleotide sequence ID" value="XM_001731076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX35"/>
    <dbReference type="SMR" id="A8PX35"/>
    <dbReference type="ESTHER" id="malgo-a8px35">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GeneID" id="5855858"/>
    <dbReference type="KEGG" id="mgl:MGL_1311"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1311"/>
    <dbReference type="InParanoid" id="A8PX35"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013434223" description="Secreted triacylglycerol lipase LIP4">
        <location>
            <begin position="20"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="115"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="360"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="W3VKA4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18000048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="455" mass="50207" checksum="22CC6B41BC1BAFA6" modified="2008-01-15" version="1" precursor="true">MKLNLFILGLLTLAAHAYALVARDKLLLPHEDPFFQPPDGWQDKEVGTILRSRKVTIKTLVKDNLKEAWQLLYRTTYTSDDEPTTTVTTVMVPHNAQNDSLVLFADFEDSSADRCAPSYSWRAGSLDDPSASTRVAIAMLYLQEGYIVTMPDKEGNRGAFGSGHVEGRQSLDGIRATLAFDKLGLSKDTRVAGHGYSGGGIQIGWAASLKKTYAPELNVVGWSAGGVPSNLTALIEKINGSPFAGFVVAGLTGVSSTYPEVKEYMEKVFTKQGLEDMEFPKKFCSTGIVLRFLFKDFFAKDFSKVGDRYLYEPVVRNILEKLTMGTNPDYTPDAPMLLMQAKNDEVAPYEAVKKTYDSWCQEGAQVHLVTLNNPLSSHASTTVTSSLPGFLWVRDRLQGKLAESGCHENKNFDVGINTNALGEDFKGILGILQGFLGDKIGPNDEYLIDWFKKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX43</accession>
    <name>A8PX43_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731136.1">
        <property type="nucleotide sequence ID" value="XM_001731084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX43"/>
    <dbReference type="FunCoup" id="A8PX43">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX43"/>
    <dbReference type="GeneID" id="5855437"/>
    <dbReference type="KEGG" id="mgl:MGL_1319"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1319"/>
    <dbReference type="InParanoid" id="A8PX43"/>
    <dbReference type="OMA" id="DDTVYAC"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="382" mass="40664" checksum="66C4A3FF64337254" modified="2008-01-15" version="1">MAEAERHIVIVGGGIIGISIAYYTSLRSDCPKVTVLESSKDLAPGASGKAGGFLALDWHGTSTASLASLSYELHHELAKKENGAELWGYREVETHQLSLDTSRKARSRPKIDWLNQQVFISSSPIGGGGSTAQVTPGELTQFLANKAKEAGVEIRLQTKAIGLDLNESSRVKGVKIQVNGEEQVLPATDVVVAAGPWTGKLLQTWFTPSTMPAYLRSASMIEGSRAHSIKIQAAKGHQLSPDCFFSEMRYGNSAGAPEFYIRPKGVAYVSGGSDDVPIPELADDVTFDPKRTAELQIQAGVLSPEYLDVKNDAELLAEQACYLPISPRTAAPILGGSAENGIYVAAGHAVWGISNSLGTGKVMSELLLDGKSISADIHHLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX80</accession>
    <name>A8PX80_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731173.1">
        <property type="nucleotide sequence ID" value="XM_001731121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX80"/>
    <dbReference type="STRING" id="425265.A8PX80"/>
    <dbReference type="GeneID" id="5855480"/>
    <dbReference type="KEGG" id="mgl:MGL_1356"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1356"/>
    <dbReference type="InParanoid" id="A8PX80"/>
    <dbReference type="OMA" id="QRECVIS"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="418"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="60925" checksum="6613FF117D7D5728" modified="2008-01-15" version="1">MQEKQPELFPDDETIDTDTIDPEESSHSGAKKQWIEAKSGRRAWGEYELFDDSFGVHPQIVLHVESPNALTPVDSPDTPGSDHMSSSTSSSPGTFTRTPRKNSMASRSLRHSIQQLDLGKPAQEIPTIASRDYKGAEEMNEVAPGFHHRRIVIPLKADERFFDLLILAIRRLLQLHVSQQRTLTMHVESLCSTIAEVASPVNSHNDMYVWREIFSLWLEFDIFEGTREKDRGEMSVAASESRLHKYLEALEKRGLLTPHQSIEQRGKTLAGTLDSWALQAFSPTNPLTDPRSIATLEHFLRLNVALVTIKRFERLNIETIRKLFKKHAKKTSLHIRENINRISSSSKAQQLLRAASFDSPIPELDWSHASVGDVLKSLTALAPSKFQASFQLSLPRIVSCLLTKALMPVLPSVDDYSCSVCTSIAWHPIRLCCGHLFCIRCLVKLQKQGMNECPLCRAPNAVRDADENNLDCDMMKYLQEWFPREVEEKIKENKSDRSVEQRHEKQVRRKNRWARFRTRYHPENEPQRECVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX86</accession>
    <name>A8PX86_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_1362</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731179.1">
        <property type="nucleotide sequence ID" value="XM_001731127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX86"/>
    <dbReference type="FunCoup" id="A8PX86">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX86"/>
    <dbReference type="GeneID" id="5855486"/>
    <dbReference type="KEGG" id="mgl:MGL_1362"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1362"/>
    <dbReference type="InParanoid" id="A8PX86"/>
    <dbReference type="OMA" id="MIDPPKQ"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="108"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="295"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="589"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="610"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP43965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="638" mass="71780" checksum="F5AB8ED6F23E5640" modified="2008-01-15" version="1">MEDEDDEEDEAVREEGNQDPLGDEEEEDGHDDEDDAEHDEDNDVDDDDSASDVSETTRERRNAFFAKEEPKESPIPTDFTALQLNRALLRGLAALNFSRPTPIQARTIPIALAGKDIVAGAVTGSGKTAAFLIPIMERLSYRQRSADDAKSRVVVLCPTRELAIQCHSVAQALGKFMNVRFCLCVGGLSLKLQEAELKTRPDVIIATPGRLIDHVRNSASFGMEDVEILVMDEADRMLEDGFEDELNEIVRLCPKQRQTMLFSATMTEDVDQLVRLSLRTPVRLFVDPKRSTASKLTQEFVRVRAQSRLTGHARQQAEDQHRAAILVTLCMRTFRDQVIIFVRSKKLAHQLKILFGLLGLSAAELHGDLSQEQRLQSLSLFRDGKVDFLLATDLASRGIDIRGVQTVINYDMPAQLEPYLHRVGRTARAGRQGRAVTLVGEPDRRLLKTVLKRTPPEQVKHRLMPSEMVQKLSDTIASLKPEVEQILQEEKEERALRQAEMEVQKGENMMAHQDEIYARPARTWFQSEKAKADAKQVSREQQNAKVDVSKARDRFAGLSRRKKRNKLMREEDAKETNQREIDVAVRAAKRLQRPSSLGARVTSKTNKANKNTKKAKMSKALHSSKKGGAFGSDMGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXD8</accession>
    <name>A8PXD8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731231.1">
        <property type="nucleotide sequence ID" value="XM_001731179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXD8"/>
    <dbReference type="GeneID" id="5855538"/>
    <dbReference type="KEGG" id="mgl:MGL_1414"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1414"/>
    <dbReference type="InParanoid" id="A8PXD8"/>
    <dbReference type="OMA" id="KWGVEPL"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="738"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="957"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1123" mass="123287" checksum="DF952E9B6FE1F7CB" modified="2008-01-15" version="1">MLHEQHHVLQAASILTGDRDIELGIRKLAKGSACVDHVLQRRLELFLDSGASLSPPEYLLSMRASVQWLTGVWAWTCALEIHRLAESHEAPTQKEAAPILGVRDLNMLKKLVTVSFAWLIIPAILAFDAAYPSPPCLDELVSAFRTLLHKNTSRSSSLTALPDSPMAHTDVAILVMRMYFVDVLRVLIRLAYGCSSAHAHALLDALLEALPTMSVLTALRSVPMPSALASSASATSGEESQSKRPLQPPPRFVREQCARLLSLQLLRPSGTRSLLIAMLGANEHDMLSGDMDLESNDGDASLARLDSVAKLLCTPPKGMRRTTYYMDMVPHILSVLDPVTPPGTTPVHGIHRRAAALSCVRMFETDSHAMCAAMQTHVWNVLLPTPGESPPSSASAVDSALRQQYAAMILAPPAPHWIHALCGPVLSRFLALDTHLHAPSSTPRIVDAVRESHAKSLDECLSTWLRLDSDEGIIRLLHDALRQALNESWHWQDTPQGVSLVQSSASEMDVASLLERPASLERVLRPESLDDEPHMPEGLSRTFAWTIDPARVCDILHRAKRTSVASALVLDAMEEHRRTRSKRISGLTHDDPITLERHAVYFLQLIFQLLSTFGQDLLQGDIERVLHLVDFACQDESALDTELCNTALELLLALLEQNTTLTPASTPLLRVIFDKIERLRDAPNLDTRALSQELALTLSARMKHVSLASSAPAAVDQAACSKTPNDRAATLPDYLCVYEEALQSLQDPILPVRAHGLHLLTRLVSTETRLHSAPCYGHELDPALVPAILDLFLRAIQDDESFLYLNAVQGLSQMATGWREAVLRPLMAIYVGGDKTSDGIAHTVAYGNTLSQRETDQRLRIGEAMLQVLQHLGEAAVSELPHIVPPLLTAVRNPVFPASLRSSFISILGTLVETAPQALAANGVSIEMVRMCTELLQGTTERRPMRRRERVRAMVHGTDALGQRTERRLGGSDDEDELDADDDGGARDGTSSTMSMAHREETSGIDTDVHRPTLRRSALLLLTWLLQKTVQQLDEYHEACRRDVDHVDAPLTALRLPGGGMLPDLGGRPKPVLPPLLVPVDTLSSFVPIVSYMAQEDADEIARIQARDCLDFVDRVKTAFLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXF3</accession>
    <name>A8PXF3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731246.1">
        <property type="nucleotide sequence ID" value="XM_001731194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXF3"/>
    <dbReference type="FunCoup" id="A8PXF3">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXF3"/>
    <dbReference type="GeneID" id="5855553"/>
    <dbReference type="KEGG" id="mgl:MGL_1429"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1429"/>
    <dbReference type="InParanoid" id="A8PXF3"/>
    <dbReference type="OMA" id="DYEKCPF"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="158" mass="18181" checksum="942BF6C0C404306C" modified="2008-01-15" version="1">MSNVELGVQTERAFQKQPLFLNSKVARKSTRAKRWYKDVGLGFKTPSAAVSGTYIDKKCPWTGLVSIRGRLLSGKVISTKMTRTVIIRREYLHYVSKYNRYERRHKNLAVHVSPAFRVEVGDIIVAGQCRPLSKTVRFNTLKVIKNKSTERAKMFSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXH6</accession>
    <name>A8PXH6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731266.1">
        <property type="nucleotide sequence ID" value="XM_001731214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXH6"/>
    <dbReference type="FunCoup" id="A8PXH6">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXH6"/>
    <dbReference type="GeneID" id="5855573"/>
    <dbReference type="KEGG" id="mgl:MGL_1449"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1449"/>
    <dbReference type="InParanoid" id="A8PXH6"/>
    <dbReference type="OMA" id="HKPIYTP"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17747" checksum="FF47B4C23CE7C396" modified="2008-01-15" version="1">MCVHIDASSAYLLTPLLQTSLAFSRLWHHVDARERVLGGLARSIAVTLMGKHKPVYDQSRDVGDYVVVTNAEHITVTGQKAEKKLYRHHTMYPGGLKEIPFKTMMQTKPEQILRRAVSGMLPKNKLRERRLERLKIFPNDVHPYEANIVKRYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXN2</accession>
    <name>A8PXN2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731303.1">
        <property type="nucleotide sequence ID" value="XM_001731251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXN2"/>
    <dbReference type="GeneID" id="5855610"/>
    <dbReference type="KEGG" id="mgl:MGL_1486"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1486"/>
    <dbReference type="InParanoid" id="A8PXN2"/>
    <dbReference type="OMA" id="PYTHESH"/>
    <dbReference type="OrthoDB" id="3358861at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="930"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1069" mass="114128" checksum="E6C9FF10D1D50550" modified="2008-01-15" version="1">MNVQLDRNQPRTPATDSRALQNLIKAEKTYVDELLSATSAAFGAASSLHAWGISETPDLDHASDIVAQYLEKAANAQKTYAQSLDQYRESLKDMLNREQSIRSIVRDRDILMSRVIKLTQRKPTKRELMKGEEEHQMRMLDAQRELQACEQTLANETAALIGVKRRTFKEALTMRAKVLGDTGAIMMDNAREILVFLDTFDADIPVAPMPVDPMDRSEHLYGAAPVQKRSSADQNIFLSDADTLYQIMPETRPQQQQVESVQQAGQLEHADYGVPSDEAALMMSPGLEGEPVYDVDPSPYDGVVPDDSLQPQLAQQPESFGTRLSPLPSKSSARRPQRSGSMASSVRSRDRPSRASRTGHRRASSSLSSQLPSMSLPSVPGGVPSAPRMNLEHARDGFVAPIVPGGVPSAPRLFAHHDDDMAASTVDSSVVQRPTRRRQADSDDEDQGFLRRGSTKHHYGGGGGGGGFFSRVSNLFRTDIRASPPRSHRRSGSESLLAPLSGSSRAPTRSSSRVFRDRGGDSSDEEPAGVMYQHFNERPALQLYSTQSGPRSPEEQALDEAIRQSVMGAGLGSSTRSRPASRQSDVVGGIKTGAPSKAATRPRKPRSNSVDLGNGATVQRVESTSSSTRKVKKRSSVDRVGATGTTASTTTTSPPGTATKGKKKRDATAFPPPAPSSFYNPGKYATDSWVPRADQLPARPASAQGLTSTRASTPLKSAMKSKESPSVRGRRISIAEADSNASQVASSRSELPPALSYMNIAAATTPTPTATAATTTTALGDADARSLPYTSLSPTTTFTPMSLDLGRPVDGTGSLGMNLTDSDSPTKRSSMPAGLAPAMSYLSVKSSSQPPTLPRITMDDNMGSDATDLYRAWMASSEAQPTSSSTTASEPAVAPADAVPSMSSKVEPAMTWASPTPSSVHTPSYMVKSPTMNTSSALPYGTQASSPALGRNASHIVTKSTSSGNGHGGAVSRLSQPMNIHNAGQHVPYGSQDDEEDSGPLRRRTSDWNTRIGRRDDSSDEEDSAAGLGGANDYYSARMAFGKSTRHLGLATGTIQPKPPGEKRKKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXS1</accession>
    <name>A8PXS1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731329.1">
        <property type="nucleotide sequence ID" value="XM_001731277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXS1"/>
    <dbReference type="STRING" id="425265.A8PXS1"/>
    <dbReference type="GeneID" id="5855636"/>
    <dbReference type="KEGG" id="mgl:MGL_1512"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1512"/>
    <dbReference type="InParanoid" id="A8PXS1"/>
    <dbReference type="OMA" id="IRHERPW"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="8">
        <location>
            <begin position="104"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="654"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="749"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="930"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="936"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111600" checksum="864BD535FA059DC0" modified="2008-01-15" version="1">MQALLASATRREGRASMSSSVDRTASATGAGAESSAASGDTNVGGFWWQERRFPFLFPPPQIPLSLPPPVRLPRIPLFERWRLRWHDMSHLRRLVAHDDKDVETFPELEWDAQVRCSSDLHADEKSAMRKRRLLMSSEGTNALAQFLQLPSSEYVHPDDVPLIAIGGSGGGYRAMFGYAGFLKEAENTGLLQCTMWSSAVSGSCWTLAVYYTIAQCSTDVMIAHLLAMAHEEAHPMSLHAMDRVARSSRGIYYLLGPLLRKSRNKTLHCRIMDFYATLVLSYQFLPRPLSLFGTDYSYNGPDSRREPSLQEQAMWAKYEPSEGLSRKSFQWSKVWTRAKLNEGLQPIPILTGVRRVWRPYSKAEVTVADNVPGHEKTPLVGSGYDWYEISPLELGCRNIGAWIPTWAYGRAFENGQSKHRGPEEMLASIVGQCTGAPAGPLTAYISTLLASIPQGTVMSTLLKWVNNFVMMKQWEKRWGNPIRAADEPNPFYGRGQDDVIVDMGPTLEKVEPPASAVTHSPRALSPGPAEAQQPRISRPTSKLHQPSESAQASAPTEPNLPHTPSQQDMPYERESNEQASPSIKRPEPAHTLPWEMWHTGEQINAFLANLPRLPELAMEHTLRPRRDSGASASTSLYEHDPETFMAPIEDLEDVTPTFDENGKGQPAADQPSQPRSKQWRWEHTRRLRLMDSGLSNNLPNHVLARDERQADVIISFDASSDVKTGAAVARIHEFGKECGIEIKKRELNYERPRTDGNETTSGENRPGRVANGSVSPSELERHYKDEADKIREEYEPLSAQRFDGWRMKKNRSTDRAPDVHFVYCPLLPNAVQPGFDPTTAHYSTSYNLIWTADQVRALLRTAMANVEENSYAVGVIRDAVREAYENKKKARLTREAQLRSMYRPQYSHEMRASPEPMDQAQDRCEGLPLRHESSLNTPAPTTPDANATTKVAPPIIPTATTRPLNSTPSLGSPAQGHAAAPSPPASDPLSMLAPPISLTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXY3</accession>
    <name>A8PXY3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_1551</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731368.1">
        <property type="nucleotide sequence ID" value="XM_001731316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXY3"/>
    <dbReference type="FunCoup" id="A8PXY3">
        <property type="interactions" value="628"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXY3"/>
    <dbReference type="GeneID" id="5855675"/>
    <dbReference type="KEGG" id="mgl:MGL_1551"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1551"/>
    <dbReference type="InParanoid" id="A8PXY3"/>
    <dbReference type="OMA" id="LRWTPYI"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP44154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="235" mass="27867" checksum="486E40466BEB8F67" modified="2008-01-15" version="1">MKRHRQKCTLLHPPGNEIYRCEDISFFEIDGRRQKTWCRNLCLLSKCFLDHKTLYYDVDPFLYYVMCQRDNTGCHMIGYFSKEKESAEGYNVACILTLPQHQRSGFGRLLIEFSYELSKRENKLGSPEKPLSDLGLLGYRAYWSETIVELLLHTNEEVSIDDIANKTSIVHADVLQTCQALNMLKQYQGKHYLVLSDAIIEKHERQMKKKRRRIHPEHLHWKPPVFTRDQLRFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXZ0</accession>
    <name>A8PXZ0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731373.1">
        <property type="nucleotide sequence ID" value="XM_001731321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXZ0"/>
    <dbReference type="STRING" id="425265.A8PXZ0"/>
    <dbReference type="GeneID" id="5855680"/>
    <dbReference type="KEGG" id="mgl:MGL_1556"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1556"/>
    <dbReference type="InParanoid" id="A8PXZ0"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="309" mass="33604" checksum="1BD9986BA150E433" modified="2008-01-15" version="1">MLVCGSKFQLNGLLYEMCAMHMLYATALSNEAVAIVDSLGAYEQNVSLRADECKRCNDRLKMATDLLCRASGVCDYVATQLLPSGTARPDSALPSLPPELRHTGILACSKLAMADAHALAIRKLLASAVGTDQITPGPPLPAGHASPSLLAKLHLHTSALYHQAHTLASHSVGVDASSPKDKLVSKLSSLRPDSHDGLAALLKYASFEAHVHKVLAYKWLGIDAGEYSHKPGWALAYLDMASVALDELMPSKAREAWRIASKKSRKETRLVMEYTSVRRWFVAYKKMNDTVCTNEGERRAGGWCGCVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXZ9</accession>
    <name>A8PXZ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731378.1">
        <property type="nucleotide sequence ID" value="XM_001731326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXZ9"/>
    <dbReference type="FunCoup" id="A8PXZ9">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXZ9"/>
    <dbReference type="GeneID" id="5855685"/>
    <dbReference type="KEGG" id="mgl:MGL_1561"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1561"/>
    <dbReference type="InParanoid" id="A8PXZ9"/>
    <dbReference type="OMA" id="SYMAFPN"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="170"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="312" mass="33990" checksum="2604473AEF29C3F5" modified="2008-01-15" version="1">MVVVLPGDVIANAAHASDQIKLGPGVLPTPDVPDTPASLTSIHTGALGHVVTKQRRRESRPATMHGWYVESAQRRYVPSVGDRVIAQVTNRGMESYTLTLFSAHPSTLPVLAFEGATRRNRPNLQIGALVYARVVNAEPWSEPELSCIDPIHNKADGMGELKATEPDVAMVWQVSLSLAQSMLRPQHTLLLNVSKHFAFEAAIGKNGLVWVRTAQAEHAIALGRVLAAADKSCQTHALASSGRGQGNGGHARDTGEHNDDMDVDNDNDDSDNDKANEHDERAKEEETPKTLHQRIRARGELRKEDIAELVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY36</accession>
    <name>A8PY36_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Threonine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1583</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731400.1">
        <property type="nucleotide sequence ID" value="XM_001731348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY36"/>
    <dbReference type="FunCoup" id="A8PY36">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY36"/>
    <dbReference type="GeneID" id="5855707"/>
    <dbReference type="KEGG" id="mgl:MGL_1583"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1583"/>
    <dbReference type="InParanoid" id="A8PY36"/>
    <dbReference type="OMA" id="TRFEYTK"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="12">
        <location>
            <begin position="489"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="573" mass="63011" checksum="D366871E3413D175" modified="2008-01-15" version="1">MNSPAAPALYIHREAKTYTVTDTTKHTYELLPKYHRLDDGTPDYLRMILGAHLYDLARQTPLVAATQLSKRMGCEILLKRDDLQPVFSFKLRGAYNMMRQLEDTRKWKGVIACSAGNHAQGVAMAGAHLSIPCTIVMPRGTPSIKWENVQRLGAKVVFHGANFDEAKAESMRLAEAYGLTMIPPFDHPQVIAGQGTVAVEICSQTDMEKVDAVFCAIGGGGLLSGVAAYIKRVAPPHVKVIGVETYDADAMAQSMEKGERVELADAGLFSDGTAVRLVGDETFRVCNSLVDAVVRVSNDEICAAIKDVFEDTRAITEPAGALAVAGMKRYIALQGADATSRRFVAVVSGANMNFSRLRFVSERAELGEQREAIMSVTIPDVPGSFLQLNKHIYPRDITEFSYRSNGSSQARIFASFLLKGTVPASEENPIVSSTKPPVAVSNLRELEIQGILEGLRKDGMHAEDMSHNELVKAHSRYLIGGRAIVPHERLFRFQFPERPGALQRFLTGIDAGWNISLFHYRCEGGDVARVLAGIQVPPETGAKFDQFLEELNYAYVEETQNPIYMQFLLANNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY95</accession>
    <name>A8PY95_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1618</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731435.1">
        <property type="nucleotide sequence ID" value="XM_001731383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY95"/>
    <dbReference type="FunCoup" id="A8PY95">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY95"/>
    <dbReference type="GeneID" id="5855742"/>
    <dbReference type="KEGG" id="mgl:MGL_1618"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1618"/>
    <dbReference type="InParanoid" id="A8PY95"/>
    <dbReference type="OMA" id="YSVSAGC"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="114"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="22313" checksum="4D152ADA6B9A0269" modified="2008-01-15" version="1">MIVEQLGMKTSQENRMSVYLAASALAEFFADIALCPLEATRIRLVSQPTFANGLVGGFARIAREEGIGGFYAGFGPILFKQVPYNMAKFATMEIVLENALHMYGKTKAQLSHSEATAFNLGSGLIAGFAAATISQPADTLLSKVNKTKALPGETTTGRLIKIAKDLGPVGLFTGLTTRLVMVGTMTALQFGIYGQIKTALGATNSVEIAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYB3</accession>
    <name>A8PYB3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">2-(3-amino-3-carboxypropyl)histidine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731445.1">
        <property type="nucleotide sequence ID" value="XM_001731393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYB3"/>
    <dbReference type="FunCoup" id="A8PYB3">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYB3"/>
    <dbReference type="GeneID" id="5855752"/>
    <dbReference type="KEGG" id="mgl:MGL_1628"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1628"/>
    <dbReference type="InParanoid" id="A8PYB3"/>
    <dbReference type="OMA" id="QIWNENH"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="64088" checksum="95C62CEC2DAEB762" modified="2008-01-15" version="1">MATAFSSADAAIIEHRVELDPDAVQATASASGRAVEELYDIESTARQLVYERNSAKKMTPPLQRVALQFPDEALIDSVPVYHALNKALKSLTDTPPRLYILADTSYGSCCVDQVAASHVQADALVHYGHTCLSATASLPSLYVFPKHPVAIDDVVDGLLRASNELVPSDRAAVVLTYDVAYTHLMEQVYEKLLPRWPHSIPLVLSRIEVNQRFHAQCAARSRSDPGSEPSDSPRSCQACGSCVSCMPQTHNAQKMHIEPTSSLLGMRQMSLPAGSSLLNTAALYVGGESRALTHLLLTLGPQYPMVSYDPKTHTIRSETGRTNRLLMRRYAAIQKARDASVVGLVIGTLGIHAYLPLLNELRRILTSPASRRKVYTISVGKLNPTKLANFLEIDVFVLVACPENSLLDTREFLRPVVTPWEMMLAVQAHGGKEVAWSGAYVLDLERVMRDASCMDLNAAGDVSDDGNDDDERPHYSFATGTYVSRTKYGTSDHVLSRSGNSEGFTQALERLSVQPQEVAVRDPKSGQVVKVLDSAALAHRTQRTWHGLDLKEGTPHAAVLEEGMAGFAQRYEDADGTREGSASRGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYC5</accession>
    <name>A8PYC5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1635</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731452.1">
        <property type="nucleotide sequence ID" value="XM_001731400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYC5"/>
    <dbReference type="FunCoup" id="A8PYC5">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYC5"/>
    <dbReference type="GeneID" id="5855759"/>
    <dbReference type="KEGG" id="mgl:MGL_1635"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1635"/>
    <dbReference type="InParanoid" id="A8PYC5"/>
    <dbReference type="OMA" id="HQTLYSE"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="169" mass="18030" checksum="E4D3FE9C2414D176" modified="2008-01-15" version="1">MVFALASRTLRSSSYRPALSQLAGARRGYAEAVSDKLKLSFVLPHSALYNAQEVTQVNVPAISGDLGILSAHVPTVEQIRPGVLEVIESSGTSKKFFVSSGFATIHPDNHLTVNTIEAYTLDKFSQESVRQGLAEAQRVASGNGSPEEKAAAEIEVEVFSAIQAALSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYU5</accession>
    <name>A8PYU5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase epsilon subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in DNA repair and in chromosomal DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731543.1">
        <property type="nucleotide sequence ID" value="XM_001731491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYU5"/>
    <dbReference type="FunCoup" id="A8PYU5">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYU5"/>
    <dbReference type="GeneID" id="5855850"/>
    <dbReference type="KEGG" id="mgl:MGL_1726"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1726"/>
    <dbReference type="InParanoid" id="A8PYU5"/>
    <dbReference type="OMA" id="FFCEGCF"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000799">
        <property type="entry name" value="DNA_pol_eps_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="316"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="525" mass="58747" checksum="CAF5735F24522DA9" modified="2008-01-15" version="1">MAEESGSLHVPLDVRRVMLRAFTKKRHLQLQSDAVQFMYRTLEEHDLLVDEDATTEAIDALASALVDQHVAGANIAGFDGHVVTAQALQKVYDQLLVESADDANANAMPLTQGSIPDLARYFSVCDAFHQPYIRFHAPRQVFEKVGRRGSLLSGAQAPSAHMEERYQLLRSIVLRNEHFLPALTGPTSSRSSMMQLTTTKHLLGRQGEHCLLFGRLSTSADGTYILEDTEGYVPLDLQQAVAGEGIFTEGAYVLIEGEYTNSEQLRVWAMGHPPSERREDARQIAGHLDWYGTGAVPTKHVSALRAQELQHPDVCVTVLSDVHLDDPVTLAHLRAILQGYQDADFVPLAIVLCGHFSSTPVEVDGALETYAASFARLADIMTRFPRLLESCHWVFVPGARDPAATPLLPRPRIPAPLVERFERRLPRDFCETRLHWMSNPCRLVYFSQDIVIFRDNIMSKMLRSAMLLKDHLEAGDLQKYLVSTLLDQAHLCPLPPQVRPILWEYAHALRLYPMPSAVRLKAEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ21</accession>
    <name>A8PZ21_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730882.1">
        <property type="nucleotide sequence ID" value="XM_001730830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ21"/>
    <dbReference type="GeneID" id="5855189"/>
    <dbReference type="KEGG" id="mgl:MGL_1881"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1881"/>
    <dbReference type="InParanoid" id="A8PZ21"/>
    <dbReference type="OMA" id="WIHAPES"/>
    <dbReference type="OrthoDB" id="3335672at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="398" mass="44897" checksum="5F79F93BCBC946DA" modified="2008-01-15" version="1">MASSSRNLTAWDVAALRVSQLNATDDMPALSRAASLKSTYGLRALPINLGSLEDLGLNPSQCKELEADDVPASTKDLPARSPHDSMDLYPISFLLRQDVLMPCPNHWTGLSNATIRLRRGRRVVHGTVERQSPYWHRMYTPHASEAGPLRASIPLTSADLDRSHAVYQRSALTSRANRRRSRTAHRSLEEAAASKRDATVESGDLRHRLERVVKDVLPQTVLWTEGNERTWQEDRYGWIHAPESDDRIPASTMLESLHFYAAQFYHANDALQPVHAIATPSDISPSACEEIRNALLKEVPDSMLPGTPLWEYWARHSLGCGRSMLQRFDGSAIVALGSLVRAYTQHVLPRQAMMQRSKKQAPLADALRAERRDRTRWRVSRAKKHAHVQAFLNKFQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZV8</accession>
    <name>A8PZV8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Anthranilate synthase component 2</fullName>
            <ecNumber evidence="9">4.1.1.48</ecNumber>
            <ecNumber evidence="8">4.1.3.27</ecNumber>
            <ecNumber evidence="10">5.3.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Anthranilate synthase, glutamine amidotransferase component</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Multifunctional tryptophan biosynthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">MGL_1954</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two components I and two components II.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="9"/>
    <dbReference type="EC" id="4.1.3.27" evidence="8"/>
    <dbReference type="EC" id="5.3.1.24" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730955.1">
        <property type="nucleotide sequence ID" value="XM_001730903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZV8"/>
    <dbReference type="FunCoup" id="A8PZV8">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZV8"/>
    <dbReference type="MEROPS" id="C26.959"/>
    <dbReference type="GeneID" id="5855262"/>
    <dbReference type="KEGG" id="mgl:MGL_1954"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1954"/>
    <dbReference type="InParanoid" id="A8PZV8"/>
    <dbReference type="OMA" id="EPIEWAN"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000003">
        <property type="entry name" value="Anthranilate synthase component II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="16" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="23">
        <location>
            <begin position="37"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="24">
        <location>
            <begin position="251"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="25">
        <location>
            <begin position="611"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00018819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00020654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EDP43741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="790" mass="85414" checksum="587858897A14956F" modified="2008-01-15" version="1">MVHGSSEPATLESIEQVHDDGRICIWSPHGTGRGITVIIDNYDSFTFNVAQLLVEEGANVVIFRNDKVSIETLESLRPVNMVISPGPGHPLTDAGISLACIKHFGGQIPILGICMGLQCMTVAFGGVVSGAGEIFHGKTSMMQHDGCGLFAGLSTSVPITGTRYHSLCAQIDAVPDVLRETAHVDSGVVMGLRHKTYTIEAVQYHPESVMSEYGHEMVRNFLSWHGGTWAENPHVLNTPASAGPSTSESILTRIFRQRKLDVAQSQTIPGRSLADLEASIALQLDPVRIDFPRRLLHGTERGIVPGIMAEIKRASPSKGDIAPNTHAAEQALLYARSGANVISVLTEPTWFKGTLEDLVMVRRVVECMPRRPAILRKDFILNEYQIAEARLAGADTVLLIVAMLDDMTLQRLYQYSLRLGMDPLVEVNNAEEMQRALLLSPKVIGVNNRNLHSFHVDMDTTSRLAQAAVERGVILVALSGIQQRSDVVHYMEQGVQALLVGEALMRAEDKHAFIQALQGESSEKSVLSSSARRPRFVKVCGIQTPSAAEAAVQAGANLIGIILAPGTKRTVSTDVARAIRQSVHKAAPNTAETNTKLASVCTSTATRLSRAHEWFSWHADRMAEAAACRPLVVGVFRNQTLEEIVAVASSLQLDAIQLHGRTEELEWARYLPNVFVIRVFHVEPDMTLRAGALAEATRPGYHHVILFDSAGAAGHDGGSGMSFTWSHAPALATRCGVRVPFLVAGGLTAANVQDALDASQAMGVDTSSGVETDGHKDPSKVRAYVQKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZX2</accession>
    <name>A8PZX2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730959.1">
        <property type="nucleotide sequence ID" value="XM_001730907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZX2"/>
    <dbReference type="GeneID" id="5855266"/>
    <dbReference type="KEGG" id="mgl:MGL_1958"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1958"/>
    <dbReference type="InParanoid" id="A8PZX2"/>
    <dbReference type="OMA" id="GCIGISC"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="428" mass="46382" checksum="8A3A2D3249834DAD" modified="2008-01-15" version="1">MHHGRVMPGGAHGLCGRRHVPCGAPHDWHLSDAATTIITTCMFAGMALGAFVWGFIADIHGRLYVFHRSLLVAGIAGLFVGLTPTFGLSCLLVAVVGMGVGGSMPIDGALLIETLPLHKRHWLTALSVFFALGSVLCALMAYAILPGRSCMREDACTNPNHGWRILTTMLSCTTLVLVAARCCLCRVHESPLFLAENGRLDDAHRVLDAIELYNKGRYDIFDPVPDGQDDNCMEYEVPASRDGGIDQDLQHQDNVDPSIEADEGPLSTGIESGRISAFASAFFLSSEWGGRCGLLFALPQRRTTLTIWCLWGLLSFAFTIFNAFFPLYLQRKGSFQASTSFVQTLRSLVWYALSSVPGSVIGAALVKTAWGHLYALPLTLGLTAAALGFFALAQASFTVLAHWGASPVCWRRSSPGLYWPGIRLCPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q099</accession>
    <name>A8Q099_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731003.1">
        <property type="nucleotide sequence ID" value="XM_001730951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q099"/>
    <dbReference type="FunCoup" id="A8Q099">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="GeneID" id="5855310"/>
    <dbReference type="KEGG" id="mgl:MGL_2002"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2002"/>
    <dbReference type="InParanoid" id="A8Q099"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11242" checksum="596F15064C270C20" modified="2008-01-15" version="1">MSWIATFGCFSGAVSVALGAIGAHVLKPRMTPQPLVALAWSQPLKGVAFYGACGLMAGIMMFCGVMYQNCVLRPDSPLRKLGILGPFGGMSFIIGWLLLAYSKCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0A5</accession>
    <name>A8Q0A5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731005.1">
        <property type="nucleotide sequence ID" value="XM_001730953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0A5"/>
    <dbReference type="STRING" id="425265.A8Q0A5"/>
    <dbReference type="GeneID" id="5855312"/>
    <dbReference type="KEGG" id="mgl:MGL_2004"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2004"/>
    <dbReference type="InParanoid" id="A8Q0A5"/>
    <dbReference type="OMA" id="ARENTRH"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF27">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="777" mass="86788" checksum="34C31E8550F94DBD" modified="2008-01-15" version="1">MRRNDYLRFLSDFSQSTTSGESASTDRLLTQVYSDLMRCLDKHSEFLMRQTEAWSMYTMDNGDIHHRHQLLRRLDQINREYHDASSDRFTLYRDSASVPVIVTYRDRQWHSMLRILFVYAMLNPTTGYMQGMHEILLVLMRVFCAARDFPTKSIQPWEAKVLGLGNTNDTEADVFWCFSSLMGMFRKVFEYEQNNVSTLDQMRQVMVLTTMQSPEHWSGNGMSHCLRFLSARLRAEDPQLWLFLHANSLDPQLPYYSFRWIACLLAADLPSDVVANLWDVLLSETDESSNFDSNPHVEMLVHMCCAMLLIVRDQLLELRNLSGSDKDASPKLAVHRKNSHDVFYSCMQLLQSYPIQNARPIISLAFQMRQQTGARMLSERMNLNPRPRTRSDTHPRVNIQERLAATVQRSLHAPSHRSVSLDSKISPPTATPALMSRPEPVSTFSEQDEQPLITASPLEGSFSSSTSTQQAADPRSLLRRYTDAIQDSNAAASMSKAGTNIAAKALAWSSRAAQPSVSAAAVATKTEKTQERRKVQEFAITSTKTHDVATNAWQDPQDRNDGPPELPIPTVVDSPNDRDTYRRAVGMVETPTAFVGSTSGVRNHQTTPIATYSSPTMDEDLSTSFSLPSVETASRLSEHVPLSLGPAAAPLASLDKDDALPQIRRSGGLIRSSAGLSLSHHASTLSTHSKHSLDMDQQSFGARRISSTHRLPSMAISQAHSPTANVTITAPDTFGAMLSPNNTRTSSPFNLAPSAPTSENLDSLLAEMRTNEWVKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0B5</accession>
    <name>A8Q0B5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731009.1">
        <property type="nucleotide sequence ID" value="XM_001730957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0B5"/>
    <dbReference type="FunCoup" id="A8Q0B5">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0B5"/>
    <dbReference type="GeneID" id="5855316"/>
    <dbReference type="KEGG" id="mgl:MGL_2008"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2008"/>
    <dbReference type="InParanoid" id="A8Q0B5"/>
    <dbReference type="OMA" id="VHTHKKD"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37102" checksum="6C225DF2C059B98D" modified="2008-01-15" version="1">MGLFSQVSSAVARGGQGLKTSKDERPPEGANAEDTEELDEESGNILLSLISQLRIGMDLHKVTLPTFVLEPRSMLERVTDFLSHPDILFGADALQSPEERFIAILTYYMSGWHIKPKGVKKPYNPVLGEFFRCSYTYHNGTTGVYIAEQVSHHPPISAYYYISPENNVLIYGDLRPKSKFLGNSAATIMGGESHVVLLNRPEDGEYTISMPNMYARGILFGKMVLELGDQSEVTNKSLNMSTNVDFKVKGYFTGTYNMIDGKVMHDGNQIGEMSGKWSDRMDYKDFRTGQSRTLFDAHNANAVQKTVPPLEQQHPNESQRYVRLTLCSSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0Q8</accession>
    <name>A8Q0Q8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2068</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731069.1">
        <property type="nucleotide sequence ID" value="XM_001731017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0Q8"/>
    <dbReference type="FunCoup" id="A8Q0Q8">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0Q8"/>
    <dbReference type="GeneID" id="5855376"/>
    <dbReference type="KEGG" id="mgl:MGL_2068"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2068"/>
    <dbReference type="InParanoid" id="A8Q0Q8"/>
    <dbReference type="OMA" id="RASATWQ"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="13">
        <location>
            <begin position="124"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="356" mass="40098" checksum="8C5EE36CC18402C2" modified="2008-01-15" version="1">MDRSKSGPMAPPSARSAKHVDNEIHELASPSTITNKGGRRPYAPQWRVSPPGCVTKPLSQKDMHAWKLGTHNPLRLEQEDARTNQHVPCRRPRHSDSRTSDEAAGVATHYNKRQDVGLKARELSPIIALKRFNNWIKSSIISLHTPRVKAGPGRQGIRVLDLGCGKGGDLRKWSQHRISDMVMIDIAEVSVQQASMRYKEGRYAWPAHFYTCDAFRTPLDQVVPAGVLSPMFDVVSMQFCLHYGWDSEASARTMLSNVARWLRPGGSFIGTIPDDDTLFGRLHALEDPAALKFGNENYSVEFDERLEPGAKPFGNKYYFWLNDAVDNVPEYVVDWATLETCVWQRKNKVQATNMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0U9</accession>
    <name>A8Q0U9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731086.1">
        <property type="nucleotide sequence ID" value="XM_001731034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0U9"/>
    <dbReference type="FunCoup" id="A8Q0U9">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0U9"/>
    <dbReference type="GeneID" id="5855393"/>
    <dbReference type="KEGG" id="mgl:MGL_2085"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2085"/>
    <dbReference type="InParanoid" id="A8Q0U9"/>
    <dbReference type="OMA" id="QSCNHPD"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="174"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="647"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="88156" checksum="DCF536DEC6C13616" modified="2008-01-15" version="1">MEAMRQRLLAQQLGLQSPTSQNKQAESKEPSTPKASNKSGPSIQSWRSEPKVKMMPLSTQTSAPFISPETSKFAVGAASSTPTKAALLRRGFPASPGWPSTPSKTAENSMQSPQVGISPSSKHVSSAEREKQLRSMLSGVVTVMEKVDMSHSRVPGMQCTLLPHQVQGVDWMCRREKGKARGGILADDMGLGKTIQMLALITLHGSLEKLRAQSATKDDSDTDSESDGNHGNLVGLTSKMVMNSGTKTTLIIAPVAVMEQWQREAEEKSGHKLSVYIHHGPRRTTHVDAMKKVHIVITSYSTAANEYDQFLKATKTKVKPPTTRKQSHLSRDTDENSGSDSEDPDWGMLNSDHDCDDENGLMLASGSTAKRANRDQTRYPLFEMNWLRVVLDEAQNIKNHRAKCSQACYQLSARAAARWCISGTPVQNNALEIFSLIHFLRISPFNDMRHFEEQIHEPLKSGNQSQVELGLQRLGIILKSIMLRRTKDAHYEGRRILDLPPRIVKVVSRDFMTTSERDFYHELEDRIQSHLDANKSPQLNYMGALVMLLRLRQACNHPALVTGRSRLPAEDASEPVAEEDGQDEDEELAALLSGLSVKTRNCDRCQVPLDAKQKKRLCTGCASQSEHEEKHGIIWGMPGTMSTKLDMMLRLLDDFDNQSKGDKTIVFSQFTSFLDLVEDALRARGYNFTRYDGSMRRNAREEALQRIRTDDGVRVILISFKAGSTGLNLTCCNRVILCDLWWNPQIEEQAFDRAHRLGQTKSVYIYKLSIDGTVEQRILALQTSSTYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0Z6</accession>
    <name>A8Q0Z6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2104</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731105.1">
        <property type="nucleotide sequence ID" value="XM_001731053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0Z6"/>
    <dbReference type="GeneID" id="5855412"/>
    <dbReference type="KEGG" id="mgl:MGL_2104"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2104"/>
    <dbReference type="InParanoid" id="A8Q0Z6"/>
    <dbReference type="OMA" id="PRWYLTK"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="136"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="669" mass="75242" checksum="95F0BD1F597602F9" modified="2008-01-15" version="1">MMDDTLHEKTVDRADLDMDQNTLTKKKNNEILFNTREAVLEDAGEDDATPEMSVEVRLNNPLLGLSSEQIESNVQEFVSTKGLENYHSEFLKGALVAQAQATGDYSSIPILTQEDHEILTKEKEHKWHQPFLLYWLAICCSVAAAIQGADESVINGAILFFPDQFGLHTDRCAYYENGIDDCTGPLKPEYQAKGWTDSKVASEISKNNWLIGLVSSAPYICCAFLGCWLTEPLNAVLGRRGTIFVASFVSFATCVWQGVTNTWWHMFIARFILGIGIGPKSATVPVYAAECSPPLIRGALVMQWQTWTAFGIMLGNAASLVLFKVSDPPHITGLNWRLMMGSACIPALFVMFQVYLCPESPRWLMKKGKYHQAMQSFLKMRSAPLLAARDMYLAHCLIEAEKKHVELHGRANLSHLFTVPRNLRALIPTLILMFGQQFCGINVIAYYSSSIIKEVGNASDLDSLLGSWGFGMLNFLFAIPAWYTIDTFGRRNLLLSTLPFMAIFLLITGFAFWIDKSNQDARLGVVLMGIYVYGIFYSPGFGPVPLTYGAEAFPIRVRELGMALSTAVLWFFNALLSITWFRMKEAFKPQGAFGWYAAWCAILWVLIFFLLPETKALSLEELDIVFNIPTTKFASYQVRQIPYFINRYLLRRKVHKHPLHAIDDSMGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q189</accession>
    <name>A8Q189_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730752.1">
        <property type="nucleotide sequence ID" value="XM_001730700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q189"/>
    <dbReference type="FunCoup" id="A8Q189">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q189"/>
    <dbReference type="GeneID" id="5855059"/>
    <dbReference type="KEGG" id="mgl:MGL_1751"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1751"/>
    <dbReference type="InParanoid" id="A8Q189"/>
    <dbReference type="OMA" id="RFMHCAI"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="249" mass="27548" checksum="F68969FD45A403D5" modified="2008-01-15" version="1">MRPLFHFSGPEFECDAEIDRLAAAGADPEPQGAFLHLKSLLLDFYRGEELHPNHIALNGLEHVISVSVAPSSSGDKNKSASAPGENDLASLYRSAGVSPQTSGVSAVHRCEPRKIHFRVYTIKMIASGSKTPHIELEPCGPSFDFELRRRLAASADRMTQALKRPKTAEQKNTQGKGKRKNIDTDDMGDMVGRVHLGRQDLSTLQVKKMKGLRGQPEFDAEDRTDPALDESMDDEDVEEEDEDYGEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1W3</accession>
    <name>A8Q1W3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1848</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730849.1">
        <property type="nucleotide sequence ID" value="XM_001730797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1W3"/>
    <dbReference type="FunCoup" id="A8Q1W3">
        <property type="interactions" value="716"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1W3"/>
    <dbReference type="GeneID" id="5855156"/>
    <dbReference type="KEGG" id="mgl:MGL_1848"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1848"/>
    <dbReference type="InParanoid" id="A8Q1W3"/>
    <dbReference type="OMA" id="GRDNDKG"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="155"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="314"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="389"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="549" mass="59905" checksum="4C250B54176E6FBE" modified="2008-01-15" version="1">MYADREEALRRSQVSEIAVPPPTVTAEERERQLQEELRRRAADSRRDPRDPTGMYDTYAPSSSPDTRRASRRRGDDYDDERYSYRAPRGYTSTDGHWREDAGGRALSPSTGPRHRRGGRRHEYADDAVRSRRRSRSPPGARGSRLPPYGAEYEVKSVFCSELDSRVGQFDLGDFFESNLGPGTVVDAQLGSDDRTGTSLGIGYVELASAELVPRALELSGKRMFGWPIAVQPADAARKNPIVTMYEPPRSTGPTSTAAIPSTSSPSLSETAFVSSSSSVSAPTGPIMPPSAHSGATVSGGDAMGASAVTADPEARLYVGNLHYDITSQHVRVVFEPFGHLDEVEVCYNHMTGKSKGFAFVQFRNVHEAKQAMEQLNGFELAGRAMRVGPVNARGQGSSERSGSGRYDVPDSDHDAVPMPPPTGGSGESSGSASDKRFALMEKLARTDPENHAQRRPASIPEATSAAILLRHMFDPAEETEPHWHVDLREDVRAECERHGTVESVFVDTSSRDGEVYVCFATTDDAQRARASLQGRFFGGKRVEASLYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q233</accession>
    <name>A8Q233_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730880.1">
        <property type="nucleotide sequence ID" value="XM_001730828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q233"/>
    <dbReference type="FunCoup" id="A8Q233">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q233"/>
    <dbReference type="GeneID" id="5855187"/>
    <dbReference type="KEGG" id="mgl:MGL_1879"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1879"/>
    <dbReference type="InParanoid" id="A8Q233"/>
    <dbReference type="OMA" id="FKAHQVH"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="241" mass="27710" checksum="F0312F8EEA812842" modified="2008-01-15" version="1">MYNGIGLQTARGSGTNGYVQRNLSHLRPRDPIAPRVDDDVRKFEHVKPDASILDHERRRKIEIQCIEFQDELEEKGLPEEEIQARVASLRQGLRARLERAPTSYSQPTHAEVKGLRPSDTHARSAAKERESSKMQRALHVRPDYEEGQAFDPVLQERRKQERIEERERRRESAVLPDSRGSSRWDRVDRDMPARGARRSRSRSRSPSPARRSHVSYEDAHVPPSGKNLRTPSPPPTHTTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q273</accession>
    <name>A8Q273_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730704.1">
        <property type="nucleotide sequence ID" value="XM_001730652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q273"/>
    <dbReference type="FunCoup" id="A8Q273">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q273"/>
    <dbReference type="GeneID" id="5855010"/>
    <dbReference type="KEGG" id="mgl:MGL_2158"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2158"/>
    <dbReference type="InParanoid" id="A8Q273"/>
    <dbReference type="OMA" id="TFHFIDC"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="6">
        <location>
            <begin position="76"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="168"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30887" checksum="916C043ADB68EFAB" modified="2008-01-15" version="1">MDEYSGNPFGQHYAGYMDDGKSVGGGFLGGSQGGEAGQRRLGTNWLRPVTVRQVLNATQPDSDSPFEFDGAELSQVTLVAWIRQTNRNATNIQYTLDDGTGQLDVRQWIDNALDEGAKADEFAPNQFVRVLGEIKSFNNKRNITAATVNKLEDHNEYLYHQLDVIYTHLQLIKAEGMRSTKTDVSSTHGIDASVYDDSAMQTADSMAADLSSLSPLQRRIYQAIAAEAPDWPEGVDVQQIIKRCSKHADVTQIQDAIDELANDGYIYQASDDTHYLTTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2B5</accession>
    <name>A8Q2B5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730731.1">
        <property type="nucleotide sequence ID" value="XM_001730679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2B5"/>
    <dbReference type="STRING" id="425265.A8Q2B5"/>
    <dbReference type="GeneID" id="5855037"/>
    <dbReference type="KEGG" id="mgl:MGL_2185"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2185"/>
    <dbReference type="InParanoid" id="A8Q2B5"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="273" mass="31307" checksum="309D96C3AACC7BE7" modified="2008-01-15" version="1">MEFMVDSGDQVCQAHGYLYSSLFDQYEFHPPENWLQFEQRRLPHDATLDTDETLQPCVTFDIHLESLFKVLQVFLFRKKSPGNEDTVMIMDFPHLGGPMGLRMSHGTWDMSFHLRTYDAPFKHEMDFDSAHTAAQVIVDSQQLCPLLNEIYKNGEKAMRMEFYPAASRAQGDFLFCTENSHGTTEIVFPNKDAVTEKYMCDEPVVQSYALKGIEHMLAALTVSDKTSIRIDEVGMLSVQFKLPLVCRQDVDASQFHWHHGFIEFLCCPLVAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2G5</accession>
    <name>A8Q2G5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730398.1">
        <property type="nucleotide sequence ID" value="XM_001730346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2G5"/>
    <dbReference type="STRING" id="425265.A8Q2G5"/>
    <dbReference type="GeneID" id="5854713"/>
    <dbReference type="KEGG" id="mgl:MGL_2193"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2193"/>
    <dbReference type="InParanoid" id="A8Q2G5"/>
    <dbReference type="OMA" id="SQIVPGC"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="437" mass="45979" checksum="1E27DA2B8FE5BEC3" modified="2008-01-15" version="1">MTSPNGAGHAPPSEASHVYVEQPAAYTDATQTTHDTSDAAGARATTDASHNAGQSGIEKDVGTILAGLNQEQLESIVAAARATDSSDQHGYGTNQYDTANALAHLPPGLGQAASTLTSFASSFKRTNPPVIPTDEEITAGTALSDPPTHLGDAPPPPGMEHDMHHQRHVHSQAHKNATSAAHESAATAAALAAMGTLAGRQLPPQSQAHALGQRDGTLGADATGMDAKFVNDHTLNSARYKRKGPELDRQRKDNHKEVERRRRSAINDGIVQLSQIVPGCDVKNTNKGSIIIAAVRYIQDLKNNEASNIEKWTLEKLLMDQAMNDLSMSLDESRREVERLRAQLGMAEANSSAGASEKHAGAPGAAGGTHHYPAQRFPGQPPFQTDSNDGTHAGPDLGVSLDQSHVAHGAPGTGLDHTSMLGSHGLDTDANKRPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2P2</accession>
    <name>A8Q2P2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">54S ribosomal protein L31, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730420.1">
        <property type="nucleotide sequence ID" value="XM_001730368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2P2"/>
    <dbReference type="FunCoup" id="A8Q2P2">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="GeneID" id="5854727"/>
    <dbReference type="KEGG" id="mgl:MGL_2216"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2216"/>
    <dbReference type="InParanoid" id="A8Q2P2"/>
    <dbReference type="OMA" id="HLVPKWT"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12349" checksum="F05317BC1222B6E8" modified="2008-01-15" version="1">MSFLGAFRPSASAFSGLLWKNPWRMSATRKARVRQRLRDVDTVIDTIRTSGVQCRALECAKQLPTESEMHPRDKYMVFSPHGANFRKSVHKVPKFTRKTLRVNPRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2T6</accession>
    <name>A8Q2T6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730437.1">
        <property type="nucleotide sequence ID" value="XM_001730385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2T6"/>
    <dbReference type="GeneID" id="5854744"/>
    <dbReference type="KEGG" id="mgl:MGL_2233"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2233"/>
    <dbReference type="InParanoid" id="A8Q2T6"/>
    <dbReference type="OMA" id="MCTHKLA"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="361"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="581"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="643"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="681"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="718"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="946"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="959"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="995" mass="108133" checksum="AE0C8FB3EA057F54" modified="2008-01-15" version="1">MSTPEPASVLESRPTDAWTAAASAGTLAPSASPSSSVWCSSSSNAMPVPGPNEDIALTSSQPPPTLAFQPADSPFHEKSPIPPLPRGRHGPTNSLSTIPSFDTRPAVASALDGGLHAHPPRGRTRAGTMPSRFGAPGAPLPKFDEPLWSGALGASHVSVPRHATDFEKVSTTYNSGLPSLPDGFRLLSEKSDADALGETQESSLAKTLDYLGLGDEPRPVPRERARTDASVKPALGMMESSHHLVIDRFLQPELLQQQQQQQNRISSATSPAPPMMPTQIHPQSQAPTKGSSQPFMSRAPGFGRLRSGTVAAMSGPDGRQRTELELQRAYGMMTPDALSARVRSNSAHLHSSQPRDSREERNLYITRLSTQASTRLLLRLFEPYGMIEDILLFPQHGAASVQFEEAIQAEQAAEAGTSFIGAYLMELFSDQSVMPHFAAGMSSILPPSMDVEPVASRVIQVSALPPGTTQSELTQLFLMAGPIEHVAAQPHAVQITFERIEDARTALQLDASLPFGGAWPLRVLSVSEEDIWPRRQPRATRVGGSASIVPSSDKGGVPLPSELAPSLAPDQQREWLKVLRFQSGLDPELEQVASPVEHTYATSIPLPADGGRASRRMDHAKYRELRKTLEAHRLTQPEVDQVALEQLDVIVELARNYIGNTVVQRFFEQCSESAKTRMLEKLAPHLASIGTHKNGTWAAQKIIDCVRTEEQQDLIVQHMQPYVPPLLLDQFGNYVVQCVLPFGFPKADFIMDAMVDRCWEIAQGRFGARSMRTCLEHPDMPRHHVKRVALAIILHCVPLSTSSNGALLLTWLFESSGLAGVSTLVAPRFVPFMSQMCTHKLASGVILRILSQTADLESARLLLQTLFDVPRMQVLEEVLLDPVHGVLLVSRALLSPALERDAQVKYSQATAELLQRNDLVYVPAYRRLAEQVGVLHDVPTRVPTLKWDGNAPLHPPPTSLTSLPPGALPATTTGLSLSATLPRPASTPVFQNELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q363</accession>
    <name>A8Q363_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730524.1">
        <property type="nucleotide sequence ID" value="XM_001730472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q363"/>
    <dbReference type="FunCoup" id="A8Q363">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q363"/>
    <dbReference type="GeneID" id="5854831"/>
    <dbReference type="KEGG" id="mgl:MGL_2320"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2320"/>
    <dbReference type="InParanoid" id="A8Q363"/>
    <dbReference type="OMA" id="TEMHERM"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="55672" checksum="0C4C4C428CC6761F" modified="2008-01-15" version="1">MLRSLIMRPQRLLILLATVVTVVLISSFFSVTSFNSSKHIRTRLRQLPSYLRNQVCLSSPYAEDQTYNALAKNASVYSIGRYAIKDEQGNYRPPEFNAATVNQAPRAKAAFIALVRNDELEGMVQSMQECTCLRTSLYRTDISDEFRFNRKYNYPWVFLNDKPFTNQFKREVRKHTRAPVYFGEVPKEHWSYPDWIDQFKAFESRVEMMKLGAPYAGSESYRHMCRWQSGFFFEHPLTYQLDLEYYWRVEPNVHLTCDIDYDPFMFMKINNKAYGFTIAMVEIDTTIPTLWQTTLDFVKKHPEYLAPDNAQYFIIDDDNLEDSSYNMCHFWSNFEIGDLRFFRSKQYKDYFKHLDDSGGFFYERWGDAPVHSIAASLFLNRTQVYHFKDIGYSHGGMGHCPLGEEKYHQSGKCDCNPLEAITITEGFCMGDWWFASAEGRPPERKEYEDLIRLMEAQSSEEESEEMSEQEESGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q395</accession>
    <name>A8Q395_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2341</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730545.1">
        <property type="nucleotide sequence ID" value="XM_001730493.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q395">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q395"/>
    <dbReference type="GeneID" id="5854852"/>
    <dbReference type="KEGG" id="mgl:MGL_2341"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2341"/>
    <dbReference type="InParanoid" id="A8Q395"/>
    <dbReference type="OMA" id="CPLEKLW"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="80"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1007"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="491"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="898"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1237"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1237"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1285" mass="144545" checksum="1ED085029417772F" modified="2008-01-15" version="1">MHNTEMDAGSSFDLAEQLLRLQEDDMIIEYDVSAMDVMAQQDLVTRIVDAVASSATSVNDSDVYQCMLSCIKSVSNLPNHLAHRLLDTILSGMNATIEEVVELDSSQWAAWTEPLERYAFLLQWLVELLEKHRELFGKSDKGITKRAGSSSTLSTAFRDNGEGSWTWASSLPVVLRLFSKTLRTVPERMWTSKASRDTFISRCILRPVMLCQENEVYLKDTAIKLGIFRVVCLAVKLHGQGLNVQTSISQALQYYEHLAEPMAELLGAMRTEFDVEVLGEDVLRDFAAKSFTSLDSKGPRSYARFLVRMTELNPRSVLKLMSLLQRQQESESYPIRNAMVEVHGLLIKYLATSEDDVDAALNSKAGQLDTDDDGDDTRNAREKQMDVLFERLFERFLDLTTFVRTKAIQVCGRLCDLAVRLPAQRLRMTSLAVQSLEDKSSNVRRNAIALLVKLVLTHPYGVMHGGELNADAWTQRRDVVRSELEKAEERLAFPVTEEGEADAGIDGEDQDQGDEDMSGKMSSRSGKPRRSELDLDALAATQQSMTHAEHEKLVKLRLTMTYYEDALKFIHLLEQGVPILVQLLASTNKAEVLESMEFFRVAHEYRIHGASDGVRAMIHLIWTKDNALVMEDGSQLKGIRSRLIEVYRSLYFDPYPGLSRSEHVALVCRNMIERTFGATLAELTSLEQLFSLMHAEGLVERAVVEKLWDVYASPLPISRAQRRGAIMILSMLAKAERELVAEKMDVLLRIGLGHVGSKDLVLAKHTCIALQHVSGSTKKVKGTLAGGHVRYPMQHPMFTRLCSIIEMPSTDEKDRHSEWFGVAEQAIDAIYLLGEQPDALCTELLRHMTLAAFASTDQRTNDVYQMAQLVFVVGHVALKQMVHLELVEREFKRRKAMRDDAAQQNSGASKPATASELDQVAEQAEDDIGETMAWVRDRELLYGPESLLALYGNVVPFICSNTRQYPDIFLQRAAALTLCKFMCISAEYCEANLGLLLHLLRTSKDAVVRANAVIGLGDVAVCFGTLVDENSERLYAGLGDKDLGVKKNTLMVLTHLILNGMIKVKGQLGELAKCLEDEEMRVSDLAKLFFSELAAKENAVYNNLPDIISHLSTGEHAVDETTFMNTMRFIFTFIDKERQAENVIEKLCQRFRLTTEERSWRDIAFCLSLLPYRSERSIKKLVDALPFYRDKLYVPDVFQRFSEILAKMHQGKSSSAAAKAGDTDLREFEDVLAHAASQSTQDHALEDATQTQTAKLERRHARPLVSKGQPSRPARTTRQTRRRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3B1</accession>
    <name>A8Q3B1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-citrate synthase/succinyl-CoA ligase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730555.1">
        <property type="nucleotide sequence ID" value="XM_001730503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3B1"/>
    <dbReference type="FunCoup" id="A8Q3B1">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3B1"/>
    <dbReference type="GeneID" id="5854862"/>
    <dbReference type="KEGG" id="mgl:MGL_2351"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2351"/>
    <dbReference type="InParanoid" id="A8Q3B1"/>
    <dbReference type="OMA" id="GHENGPT"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="181" mass="18556" checksum="82E388A8B2984326" modified="2008-01-15" version="1">MVGPNCPGVINPEGCKIGIMPAHIHMPGKIGIVSRSGTLTYEAVNQTTNVGLGQSLCVGIGGDPYPGSATVDLVKMYLEDDRSEGIVIIGEIGGSMEEDAAEYLEKYNLTRPNPKPVVAFIAGRTAPPGRRMGHAGAIISGGKGGADSKVSALEKAGAIVADSPAKIGELMLKAMKDAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3P4</accession>
    <name>A8Q3P4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein RIM2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2463</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730667.1">
        <property type="nucleotide sequence ID" value="XM_001730615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3P4"/>
    <dbReference type="FunCoup" id="A8Q3P4">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3P4"/>
    <dbReference type="GeneID" id="5854974"/>
    <dbReference type="KEGG" id="mgl:MGL_2463"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2463"/>
    <dbReference type="InParanoid" id="A8Q3P4"/>
    <dbReference type="OMA" id="WVMYEQM"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="136"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="291"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42358" checksum="94B298F4AE24314E" modified="2008-01-15" version="1">MSTTFPSRSARDYPKRRNERRVPPWLHFAAGGAGGMCGAIITSPLDVVKTRLQSNLYSGRFAVEESHRSVLGLCTRGALQFVDTGRLIVEISVREGTQALFKGLGPTLVGVIPARAINFYTYGNGKRILSDFFECDSSLIHLTAAAIAGIITATATNPIWVVKTRLQLESQQREAQSRQIRAAAVGKFMASSKARISESATVPSNASSAKGLSRRTMYTTTPVRARFFQPIPPPQHPSTNAFSMTAQILRVEGIRGLYKGLSASYLGVSESTIQWVLYEQFKRTQDPCEKPSWFQTISSAGSAKLIATIITYPHEVIRTRLRQQPEEGGRKYQSLIQTFRLVLKEEGALAFYGGLSAHLMRVIPNAIVTFSIYEFVLMLGSGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3U7</accession>
    <name>A8Q3U7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">eRF1/Pelota-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730088.1">
        <property type="nucleotide sequence ID" value="XM_001730036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3U7"/>
    <dbReference type="FunCoup" id="A8Q3U7">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3U7"/>
    <dbReference type="GeneID" id="5854406"/>
    <dbReference type="KEGG" id="mgl:MGL_2470"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2470"/>
    <dbReference type="InParanoid" id="A8Q3U7"/>
    <dbReference type="OMA" id="GPGTEKM"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="442" mass="49911" checksum="7F400F77B539B85A" modified="2008-01-15" version="1">MSQPMSETDQNIQIWKVKKLIKSLENARGAGTSMISLILPPKSQLSQATNMLTQEYGTASNIKSRVNRLSVLAAITSTQQRLKLYSRVPDNGLVVYCGTVLTAEGKEKKVNFSFEPFKPINTSLYLCDNKFHTEALAELLESDARFGFIIMDGNGTLFGSVSGNTRTVLHKFSVDLPKKHGRGGQSALRFSRLREEARHNYVRKVAEYAAQHFITDTKCNVTGLVLAGSADFKNELSQSDLLDYRLAPKIIQIVDVSYGGENGFNQAIELAADSLANVKFVQEKRLIQKYFDEISTESGKYCFGLDDTFRALEMGAVETLIVWENLEHTRHVLRDSEGREHVILLNKEQEQEEDRSRFIDKATGAEMEEVEEPQPLLEWIAENYKQFGTNLEFVTDRSQEGMQFCKGFGGIGGILRYKVAFEDLAMYDEQEDEFMSDDEDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q431</accession>
    <name>A8Q431_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2492</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730110.1">
        <property type="nucleotide sequence ID" value="XM_001730058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q431"/>
    <dbReference type="FunCoup" id="A8Q431">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q431"/>
    <dbReference type="GeneID" id="5854417"/>
    <dbReference type="KEGG" id="mgl:MGL_2492"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2492"/>
    <dbReference type="InParanoid" id="A8Q431"/>
    <dbReference type="OMA" id="KMEDQEY"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="9">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="148" mass="16973" checksum="D58D4E73859A4BDA" modified="2008-01-15" version="1">MPKAKGKGGKNRRRGKNDGDDKRELVFKDESQEYAQVLRMLGNGRLEAMCFDGEKRLAHIRGKMRKKVWINNGDIILLSLREFEDGKADVIQKYTPDEARSLKQHGELPEATKISEDAFGEDEGDEIEFQEPSDEDEEQDDDEDLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4X5</accession>
    <name>A8Q4X5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubinuclein middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730283.1">
        <property type="nucleotide sequence ID" value="XM_001730231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4X5"/>
    <dbReference type="STRING" id="425265.A8Q4X5"/>
    <dbReference type="GeneID" id="5854588"/>
    <dbReference type="KEGG" id="mgl:MGL_2665"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2665"/>
    <dbReference type="InParanoid" id="A8Q4X5"/>
    <dbReference type="OMA" id="HANRSKF"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="3">
        <location>
            <begin position="316"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Ubinuclein middle" evidence="4">
        <location>
            <begin position="527"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="463"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="77826" checksum="2C33A9F514955088" modified="2008-01-15" version="1">MDKLQEGSSVQKDGTSGDSAASLREETTSGIQERALGMDKAPSTPPAVSTTQPLTSPQRCKDTTTCSDISPTQKDMAQIATTSASASRSLQGASVSNENTSKETEPSPGSLVPYRPSDATSSASGTTHSMQIDAPSHDKPKKRISPTVVSEAASTASEDAKENAPANKIQSSDKSPLSRISLPQHQAHHHEIEPKQTATSKSAQQPSRKRARSPSPVEPAPTPPPARPTIRLELALTHKPTSKSDYIFQIPNLAVDQLQDQHPEWTAWYKTTYLDQSHVSASHEVGLSAQELHDLGGLAKLLHKYPSATSSSQPARKRRVDEYDVGSYDTKDPFVDDSELGVDEPTHIVRTRADGFYVARGPVELARAKSSSVPSSRSASSFRSSFGASLGRGWAAGRTNKLLAKRAASRSQQQQPRHDQQPQPQSQQPSQNARQGVPGEISDSTTASLGPETRSGSAASLTSGPAPGPVASSSSAAPLAGGSSAMSLTAPSSSLSSASPSASVCAPGLASSTDIIDKKKDKYPKRPVHPQLQAMFDQLKALVSKASFAVKTKFPPELKPPLIETAKVAVELDEYNENFFNYLPSIFPYNRFTMMKLTKREFFHKHMAYFKELQEEHIEKLSQLIEVHFPSQAAEYEALCRERGVEGKDNTDHGADDDTEAAPDESRTSIIQPEADDLVKRFRWSDDMRDTLFTIVTVENAMSEIRNEKLYVSRRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q514</accession>
    <name>A8Q514_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferrochelatase, mitochondrial</fullName>
            <ecNumber evidence="15">4.98.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Heme synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protoheme ferro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_2696</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="15"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730314.1">
        <property type="nucleotide sequence ID" value="XM_001730262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q514"/>
    <dbReference type="FunCoup" id="A8Q514">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q514"/>
    <dbReference type="GeneID" id="5854619"/>
    <dbReference type="KEGG" id="mgl:MGL_2696"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2696"/>
    <dbReference type="InParanoid" id="A8Q514"/>
    <dbReference type="OMA" id="DPYHCEC"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP43100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="365" mass="40362" checksum="3F4A157045D0B04A" modified="2008-01-15" version="1">MMNMGGPSTLDEVQPFLTRLFLDRDLMRLPLQSRLAPMIARRRTPKVRDQYATIGGGSPILRWTRTQGEAMSRMLDELSPATAPHKAYVAFRYASPLTDECMDELEADGVKRAVAFSQYPQYSCSTTGSSLNELYREIQRRKARHSPGGQIEWSVIDRWPTHDGLAQAIVNRILEAVSTLPPDVAHKAPIMFSAHSLPMQVVSGRGDPYPPEVAATVANVMQKLGWSNPYRVTWQSKVGPAAWLGPQTAETLQGWAKQGHKHAIVVPVAFTSDHIETLYELDIELQEDAKEAGVQLVRAPSLNDEPVFLRALADMVSEHLSSDSRGTRPWAQGKASHQLSLRCPGCTNEECGPQKAFFMGSCIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q525</accession>
    <name>A8Q525_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730322.1">
        <property type="nucleotide sequence ID" value="XM_001730270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q525"/>
    <dbReference type="STRING" id="425265.A8Q525"/>
    <dbReference type="GeneID" id="5854627"/>
    <dbReference type="KEGG" id="mgl:MGL_2704"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2704"/>
    <dbReference type="InParanoid" id="A8Q525"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.130">
        <property type="entry name" value="Ubiquitin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="209" mass="23561" checksum="700C5BAEFEA7B2D6" modified="2008-01-15" version="1">MRPTSDTGTSPTPPDSNVATHIEVAPIQLVEKDSNHADLERPNPSRSSSPTHSFQSAPKQNQETYVIVLDSLGSTHGPVKTALRDYLRLEAHDKGKVDADVDIKRLGDPTHIDVRVPVQSNFSDCGVYLLHYFDRFFSQPEHFFEIALSSRRGSRTYTTVHQDWRSEDVDSKRAWWASVIQDLARDWIPDPDPHMEPCGEGDIEDVCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q591</accession>
    <name>A8Q591_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730372.1">
        <property type="nucleotide sequence ID" value="XM_001730320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q591"/>
    <dbReference type="STRING" id="425265.A8Q591"/>
    <dbReference type="GeneID" id="5854677"/>
    <dbReference type="KEGG" id="mgl:MGL_2754"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2754"/>
    <dbReference type="InParanoid" id="A8Q591"/>
    <dbReference type="OMA" id="QSACHIK"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF1">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="172" mass="19361" checksum="5D7C827246B6DCC2" modified="2008-01-15" version="1">MTALTSNDTAHKIQQGISYKQEGNAAFLQRDYVGALRSYHYATLYLAGLDEQVLQQFGGSSRGYDVREDQKQLSQVRSNMAACYLAQERFARAVHACDQALVSDPSNAKAIFRKAQALRRQGAIYQAKDWLESDAVCEYVKGPDFDAEKSRIAVSISERERKSHAKWRGFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5A5</accession>
    <name>A8Q5A5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2764</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730382.1">
        <property type="nucleotide sequence ID" value="XM_001730330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5A5"/>
    <dbReference type="FunCoup" id="A8Q5A5">
        <property type="interactions" value="693"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5A5"/>
    <dbReference type="GeneID" id="5854687"/>
    <dbReference type="KEGG" id="mgl:MGL_2764"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2764"/>
    <dbReference type="InParanoid" id="A8Q5A5"/>
    <dbReference type="OMA" id="QDASAPM"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002693">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="407"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="610"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="658"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1276" mass="142244" checksum="0FA4F1F0903CB89F" modified="2008-01-15" version="1">MTIHEDDLDEDLDAMDDNDDDQVTSETFSQVHEYTENDERQRRILDAVKKFEKKEAIPTSEPPVQVGSALARGTDDHPMQPVIRKRQRKRQVQDRSNLSIMERIVRGKSNVNQQSQDTDSSFDSDEDEEKSETSSSEGVYNVDKMIENRKLHKGKEKMTDNENDTDSVATDELESEEPDTDEDEEAVLLEAMRQRGLLPPGSEAIPENMLSNLQHPAEKRLGASKLKEDEEHGRSENDESDPSHDDENDDWDEEEEEEDGDSSDEDEENENDHQRNIDFEGTHDRTPKRRGIGESSRSRGFKEWAMEALQLARPNQDNEDGRTLEPVGGHVVRVRDLGPQDGKIRGPLGQDMPSIRSSFTQQYFDEEAFLSTLRDTKPIRHVIVERPQELQEARMQLPVVSEEDSILRTVLENPVTVLCGETGSGKTTQVPQFLYEAGFGTHGSANPGLIGMTQPRRVAAVSMARRVAEELQLPSHRVSYQIRYDATSSPHTQIKFMTDGVLLRELAQDLTLSKYSVVIVDEAHERSVNTDVLIGMLSRVVKLREKRWIDGGKGLEAPRPLRLVIMSATLRVGDFTRNTALFSTPPPVIHIGARQHPVTIHFNRRTQQDYVTEAIKKTSKIHTRLPPGGILVFMTGQQEVQTVCRKLAQRYSANVLTKSHTDEEAYSRSRSAMSSRVVEPEAEDMNLGTSEEPAIDHELDHDTQSDDDALDTDEDEDSNTLKLAESVTPMHILPLYSLLPTAEQQRVFDGAPDNTRLVVVATNVAETSITIPHIKYVVDCGRAKERHIHPHSQVQSYDVTWISKASAAQRAGRAGRTGPGHCYRLYSSALYEELFREFGEPEILRTPVDGLVLQMKSMNIDHVANFPFPTPPDRHALMKAERTLVHLGALEHVDAMSGNKRVTNASITSLGRIMSLFPVVPRYAKLIAQGHQHACLPYAVAIVAAMSVGDVFEREDCVLSLTGMALNDAAEDEAEAKEQRRAARAAYFKALREFDVLGDGLSDAFRLLSVVGAYSHEAAFGASVSFCRAHFVRQKAMEEIHKLRAQLSHLVIANLSGLSDDDTKHLQDPQLPPPNSVQIKVLRQLLASIYIDRVAVRADVVGAPEAELTPASQGAKMASTRRIPYVALGVHGPVYIHMSSVFYHRPPPEWLVFGEVHQSAPKEASMNDGKEDDMAPRTQWLKMVTKINPAWVSTLGRSLCTFSQSSEALGPSALTTAMKAVKRGQQGTALKRDVLITPRYGGSLQDGGAAGGQGWELPSLKAQQVLRNGRWTTEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6A2</accession>
    <name>A8Q6A2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Histone acetyltransferase</fullName>
            <ecNumber evidence="2 8">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 8"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729912.1">
        <property type="nucleotide sequence ID" value="XM_001729860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6A2"/>
    <dbReference type="STRING" id="425265.A8Q6A2"/>
    <dbReference type="GeneID" id="5854219"/>
    <dbReference type="KEGG" id="mgl:MGL_2898"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2898"/>
    <dbReference type="InParanoid" id="A8Q6A2"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="9">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="154" mass="17796" checksum="7A6A92F494F7B9B3" modified="2008-01-15" version="1">MLTRKEQRLGSPEKPLSDLGFLTYRSYWKLAVFRALDADPSCTLESICLRTGMKMDDVLYTLQDNRMLDVFYNPASEVGKLPVEYLSSKVAPEDQKPLPNDYRINFDADEIRAHLRKHDAKNYVRVDPSKLRWTPFLMKPQTLVNDDPVKTKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6G6</accession>
    <name>A8Q6G6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729974.1">
        <property type="nucleotide sequence ID" value="XM_001729922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6G6"/>
    <dbReference type="FunCoup" id="A8Q6G6">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6G6"/>
    <dbReference type="GeneID" id="5854281"/>
    <dbReference type="KEGG" id="mgl:MGL_2960"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2960"/>
    <dbReference type="InParanoid" id="A8Q6G6"/>
    <dbReference type="OMA" id="RKPRERC"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="184" mass="21635" checksum="F2DA62D69F0B9F61" modified="2008-01-15" version="1">MFLWRKPRERCKNPWQDRYHRLVQEKFLSLAPLILLTKLDSCYSHSRAHPSRDRDLNSPITLRTRKFLSNRLLQRRQMVLEVIHPARPNVSRSELQEKIGELYKTPKEQVSVFGMRTHFGGGRSTGFALVYDSQEAMKSFEPTHRIVRNGLAPKIEKASRKLRKERKNRGKKVRGTKKGDSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6H2</accession>
    <name>A8Q6H2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DCUN1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729980.1">
        <property type="nucleotide sequence ID" value="XM_001729928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6H2"/>
    <dbReference type="STRING" id="425265.A8Q6H2"/>
    <dbReference type="GeneID" id="5854287"/>
    <dbReference type="KEGG" id="mgl:MGL_2966"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2966"/>
    <dbReference type="InParanoid" id="A8Q6H2"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="118" mass="13017" checksum="253817E5309DCC9B" modified="2008-01-15" version="1">MLSDINLDPASVTILPLSYYLSSPSLGQFTRNGYVDGWLRIGVGASPESQGSSLTLPHLVEQQKRAVSEVMHTFTSDGLVMPEYKSSSSSSPKKGLYTTVYEYTFAFARNEGQKNLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6M7</accession>
    <name>A8Q6M7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730025.1">
        <property type="nucleotide sequence ID" value="XM_001729973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6M7"/>
    <dbReference type="STRING" id="425265.A8Q6M7"/>
    <dbReference type="GeneID" id="5854332"/>
    <dbReference type="KEGG" id="mgl:MGL_3011"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3011"/>
    <dbReference type="InParanoid" id="A8Q6M7"/>
    <dbReference type="OMA" id="CAPFAQC"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000054">
        <property type="entry name" value="Chromosome 16, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF268">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="381" mass="44228" checksum="0A2C6E6A3CC69E76" modified="2008-01-15" version="1">MYKYDNRQEVWLYLLGVLSADKSQEMTAVRNKFLEYEGVSKRIPAVEKEVRTEVLRYFRRQLDPNQRRSRPDTNASTCCNYNYLLADIRALVIRQTRLSQSDEHSELGNTSEDELFERPSIPRILPSTQYGLATMRECPNVDDSVLIHEQRRLSQSVENVLCAYLNRHLLAAAEEKPDQQLGEARACAVKSMSTQTQKEFDWPINLVSLPGNRLNEFHPSMVYLCAPFAQCVRAEAGMYFAFERLMSMIAQYNEVHPVPQRVATFLTLFRTTLPELYAYFEAEEVDILAVATSWLQHLLAREMQTHDLMRLWDTYFAVPDLLDLHLYVCLAILTNCRDALEDLDRSETMSMLFSLPPMDVDRIISDAVNIRLSLEHDEMYE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2025-04-09" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6P6</accession>
    <name>RRP36_MALGO</name>
    <protein>
        <recommendedName>
            <fullName>rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Ribosomal RNA-processing protein 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RRP36</name>
        <name type="ORF">MGL_3026</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730040.1">
        <property type="nucleotide sequence ID" value="XM_001729988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6P6"/>
    <dbReference type="STRING" id="425265.A8Q6P6"/>
    <dbReference type="GeneID" id="5854347"/>
    <dbReference type="KEGG" id="mgl:MGL_3026"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3026"/>
    <dbReference type="InParanoid" id="A8Q6P6"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000397639" description="rRNA biogenesis protein RRP36">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="261"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="427" mass="48446" checksum="14DFDCA9C2E7FA2E" modified="2008-01-15" version="1">MHLRDSTKDTLASSGNRDDDEIDDGQHAQFLDADTVDSEESIEAEPVEENEEWSDQGSGAEGSDEGGGYAQYIDPDDDIDENDEEGMEVSGNDEEENSDHEEVRILVLLNSGYITAWYILAQCTDAEIESVPYDKLLKARRIMRRQSARGHATDEEDDNEHESIEAKRDLAKKKLREMYLSSHSSSSKPKLPPTSSSSSFLASRERKNAPAVMSSRRPVSRLRQVVKPIQNAKARDPRFDSLSAGPVNLDLHAKSYGFLPDLYQTEIKQLRDQHAKLKRTEIHHAGPRAKSQQAAEIRDQRAHVEQELRRAESRQNERTRRERERSVKADFKKENQRRVDAGLKPFFPKKAQFQEALLRKQFDEMAQGSGTGSSASLRKAMDRKRRKDAQKEKKSLDAALGGGSRTDIRPMRHFSDAPRPHKRGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6S4</accession>
    <name>A8Q6S4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730058.1">
        <property type="nucleotide sequence ID" value="XM_001730006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6S4"/>
    <dbReference type="FunCoup" id="A8Q6S4">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6S4"/>
    <dbReference type="GeneID" id="5854365"/>
    <dbReference type="KEGG" id="mgl:MGL_3044"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3044"/>
    <dbReference type="InParanoid" id="A8Q6S4"/>
    <dbReference type="OMA" id="GDMFQVE"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="122"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="431" mass="48567" checksum="D84A51DCE982A1D1" modified="2008-01-15" version="1">MRKANLFRPESAIPRMSWSPRNLYNLIARSSTGRLVNELNFTKTSMTMYQQRWRSKRMLRGYHGDWIPERRFKRWFLPTSLPSYAPSFLSTVKPLSDADESDHALDSPTPPVKSLFMRDVERRIDTAVFRCCFAHSVYYARSLVLHGKVSLNGNVHRDPGYLLQPGDLLSVEPSCVPMLNGHVAKRVQADRERHAVKKSPPEVQESPTPTKENGDASVMTERSEANASAENGMALSESGESAEGAPAAASEDVKPATNTAEHSEERSKSQHSAQNDLPAGVLPFHLPPFAAPFLFVPPYLDVSFRTCSAIYLRHPTLSTSIIRSRNNNRDSKRPSTEVVYRTDIPSPYPAGGDMFGLAWELYVRNAPRVRSDERRTKHIGRYGHNGFEAARAFEQDRRRVAIRRGWGRKRRIPLPQQPQAPAHASLPNTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q847</accession>
    <name>A8Q847_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729657.1">
        <property type="nucleotide sequence ID" value="XM_001729605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q847"/>
    <dbReference type="STRING" id="425265.A8Q847"/>
    <dbReference type="GeneID" id="5853963"/>
    <dbReference type="KEGG" id="mgl:MGL_3201"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3201"/>
    <dbReference type="InParanoid" id="A8Q847"/>
    <dbReference type="OMA" id="EEWREPC"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43263" checksum="115E81FA549CE987" modified="2008-01-15" version="1">MMGLSASVPKDGKPRLQLVGPLGLRAFLRATLSITYASLSSHFIVHELLWPSQPAYPHNPEGISTFSYTEQDPYLPEGVRGQVRTLPLLPPHENELPGRDIRMNESTCTWPSILQLSNVTISAAPITHRCPTVGYVFQEGPTASRSVSQEELAIIDSNKDALFELYNIRSPRSLLSRVMRDRETITLPDGHVLSPPPLDRPGRKLCILGDTSDATAGLVGRGMAYLARDADLLVHECTYASMNAEDLEMARIESEEHAQMLQKSLLGVQEAETRALSRGHSVPRIVGSFSGEIRARRVVLNHFSARLPAPVVSTEAPLTSTHQLKQGTPFKNSVKQFYVMREIERQVTKYWHASLPEEFREFVKNDNAVAAFDGLAIDIAPHSAPTEQNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8V9</accession>
    <name>A8Q8V9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729311.1">
        <property type="nucleotide sequence ID" value="XM_001729259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8V9"/>
    <dbReference type="FunCoup" id="A8Q8V9">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8V9"/>
    <dbReference type="GeneID" id="5853609"/>
    <dbReference type="KEGG" id="mgl:MGL_3346"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3346"/>
    <dbReference type="InParanoid" id="A8Q8V9"/>
    <dbReference type="OMA" id="ERDHPDM"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="682" mass="76276" checksum="1C5D13DBD0D5A815" modified="2008-01-15" version="1">MATSSSGKNHLDETVDENVDEKGVSQRVGSGRKAAASLHLFMAAQSSGTTPNQTEHLTNPKRQDSSPSSMDSMHQAYLCRSPATAMTASPSPSQPLRPQSLLQRSMSSWNESTPPSSQPHDVLTNSTMYDDDGDKAQGASWIDTSSDESSEESDTASEQETDVEKASAAEPPRQMDGYGSYTNPLTIPSPHFSANSDVRTPHTARLHQHHHVQDSTEPPPSVVQLQPFNHQVGGHSHIFQFSRRAVCKPLTSRENQFYEALERDHPDMLAFVPQYLGVLNVTYRHVHREPVMHSADKASNQVSMTTSAPEPRRRIFHGQDEDENEVPEVAIDRNQHIMPDWLVRRSLRGNEEFDAAGNAVSSENTILGKGCTSVNRRLQEQVIREVFRQRKPRHRNKRSVSGHAGPGDRLARSWDQKKQGSSMTAFSSLDYTDSTWNQSRPRSHEDCAMSSVGMRMNVEPEVPLETGPDSTGTGDRAEVGATPRPVSRARPSPTTASPVKSSARQEQFILLEDLTGGLKAPCVLDLKMGTRQYGLDSTDAKKKSQTNKCIKTTSRTHGVRICGMQMYDARQDKFVFQDKYYGRNVKPDEFTSVLETFFHNGYQVLIHHIPVLVEKLYCLAQHACKLAGYRFYASSLLLIYDGDVRRQRALLQGFEADVLGDSRHQRGQYDGRRRPYSPRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q967</accession>
    <name>A8Q967_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729387.1">
        <property type="nucleotide sequence ID" value="XM_001729335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q967"/>
    <dbReference type="STRING" id="425265.A8Q967"/>
    <dbReference type="GeneID" id="5853694"/>
    <dbReference type="KEGG" id="mgl:MGL_3422"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3422"/>
    <dbReference type="InParanoid" id="A8Q967"/>
    <dbReference type="OMA" id="VKRCQCP"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="35"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="246" mass="27237" checksum="FC0FD8FA1715667C" modified="2008-01-15" version="1">MRWEMKGANVLFSVGNSCILYWKVGGCAADTHGLVVLGLQQCNGSFQGDKWGETDTRFLYCATNVLAHLGALDELDHEKTIQWVLRCSNFDGGFGLTEGAESHAAQVFTCVGALSILHALDRIDQDTLAWWLVERQVPGGGLNGRPQKLEDVCYSWWVLSSLSLLHRLHWIDSERLCAFILSAQDPERGGIADRPDNVTDVFHTQFGVAGLSLLGYSGLQRVDPTYCMPCHITKALGIQRPFQSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9F6</accession>
    <name>A8Q9F6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729437.1">
        <property type="nucleotide sequence ID" value="XM_001729385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9F6"/>
    <dbReference type="STRING" id="425265.A8Q9F6"/>
    <dbReference type="GeneID" id="5853744"/>
    <dbReference type="KEGG" id="mgl:MGL_3472"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3472"/>
    <dbReference type="InParanoid" id="A8Q9F6"/>
    <dbReference type="OMA" id="NQCWATI"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="5">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="196" mass="21581" checksum="23F9470DE6312876" modified="2008-01-15" version="1">MKRELHEDSSLNLGIFRTQAIRPGNVLPLRMIPIGTTIHAISLLPLGPAKLVRAAGTFGQLVTFSSLRKNVDLGESEDLTRHTHAQVRLSSGEVRLVPIDCCATIGAVSNKDHQHIRLGKAGRSRWLGRRPKVRGVAMNPCDHPHGGGRGKSKSNKAPRSIYGFPLKFQRTRRPGTRGGNRMVVRARPRRNGKRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9S8</accession>
    <name>A8Q9S8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 69 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729519.1">
        <property type="nucleotide sequence ID" value="XM_001729467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9S8"/>
    <dbReference type="STRING" id="425265.A8Q9S8"/>
    <dbReference type="GeneID" id="5853826"/>
    <dbReference type="KEGG" id="mgl:MGL_3554"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3554"/>
    <dbReference type="InParanoid" id="A8Q9S8"/>
    <dbReference type="OMA" id="FRTHPEC"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="43862" checksum="2AF7075B915909F7" modified="2008-01-15" version="1">MLCFLRGWTPRHLTIPATWNTPNSNETYFIVSLLRDSEKILPQYTQSILSFAQDVGPQNVFVSIFENDSRDRTPIMLKDFRSKLLSRGIPHHINSTQLPSSIRSYERIRRLSTLRNFAMRPMYEEMRNGLQKRPFTKVVWINDVFFNKNMLHHLLHTANGTYDQVCALDYFWLGFYDTWVMRDRYGMTVRPLWPYFRRGHDRSGINALEPVPVNSCWNGMTVFDARWFLPASAPRTSIPNAQHPTSPVIVSVPPAPLVRDDGIDTPAKLPLEFRTCRSCNVSEALLTSLDMHRIAAPRRPRIYVNPAVKVAYDYPSYYLYNYLLRWYVVQPWRYVWETWIERRLFSWLADLGNRHDSCASLLNQMWTNEPVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA73</accession>
    <name>A8QA73_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729165.1">
        <property type="nucleotide sequence ID" value="XM_001729113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA73"/>
    <dbReference type="STRING" id="425265.A8QA73"/>
    <dbReference type="GeneID" id="5853471"/>
    <dbReference type="KEGG" id="mgl:MGL_3632"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3632"/>
    <dbReference type="InParanoid" id="A8QA73"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34416" checksum="F45A113B1D2495B8" modified="2008-01-15" version="1">MEKALRLCQETDIYMTNFSTAMAKITDFFEYMDHAGTVFAHSHALNDAIHMWETITSIPTDTVHAMQYKAAKKSILLRLLRDGSTPSLEEMMPLQTLTVRTIYHRECEAYLEFARMYEKYVLGSKLALDQFVQEHNTVFANDGTLDLVHWTLSARMRHGILALARIYKTFPLRHLVAFLETQEHDVIETLTTLTNSGTLEVHVIEQELSAELHAIPVPGGTIDMDAGNSIVHFNLQLGPNIQNMAQTLEAAGSLEKRASMSLKNDLAQLLTSPAVMSRILSLSSGTSLPEAEILEEDDGMSFDTIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA85</accession>
    <name>A8QA85_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729177.1">
        <property type="nucleotide sequence ID" value="XM_001729125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA85"/>
    <dbReference type="STRING" id="425265.A8QA85"/>
    <dbReference type="GeneID" id="5853483"/>
    <dbReference type="KEGG" id="mgl:MGL_3644"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3644"/>
    <dbReference type="InParanoid" id="A8QA85"/>
    <dbReference type="OMA" id="GTHEYCD"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="36"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="402" mass="44269" checksum="7846B8817F8D4260" modified="2008-01-15" version="1">MLDDQLSKALDIRERQGRRRQLLLQNPKEAERLARLVDFSSNDYVSLARNTRVREAWLKRLHDNGESFGSTGSRLLDGDSSTHTQLEQRLAKYFKAPAALLCNTGFDANVSLLSTIPQPEDVILYDELIHASMHDGMRQSRAKVCVPFQHNDPVDLDRQLSSALGSNLLRDIQDGKRNVFLALESVYSMDGTVCALRELAHVLEKHVPCASTRHILVDEAHGVGVYGRGGRGVCDALRCTDLPSARLVTFGKAFGCSGAALLVPSLWREYLLNYARPLIYSTALSPAQAAAVDVVLTAWERGELEESVQALHARIAELYESLALPAPTAASLPPAPIVQVQSKEVKRLAAQLQDAGFLVRAVCYPTVPRDKERVRICVHAHNTSDEIARLSLAVRAVTHASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA95</accession>
    <name>A8QA95_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729187.1">
        <property type="nucleotide sequence ID" value="XM_001729135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA95"/>
    <dbReference type="FunCoup" id="A8QA95">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA95"/>
    <dbReference type="GeneID" id="5853493"/>
    <dbReference type="KEGG" id="mgl:MGL_3654"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3654"/>
    <dbReference type="InParanoid" id="A8QA95"/>
    <dbReference type="OMA" id="WPIEMAR"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16393" checksum="ADCEC0C42EA7515D" modified="2008-01-15" version="1">MSEAKGATPFVSCFGKKKTATAVAHAKEGKGQIRLNGQPISLIQPDVLRWKVYEPILMVGEDKFAPIDIRIRVSGGGHTSQVYAIRQAIAKALVAYYAKYFDAASALELRQHFISYDRTLLIADPRRCEPKKFGGHGARARRQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAA3</accession>
    <name>A8QAA3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3662</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729195.1">
        <property type="nucleotide sequence ID" value="XM_001729143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAA3"/>
    <dbReference type="STRING" id="425265.A8QAA3"/>
    <dbReference type="GeneID" id="5853501"/>
    <dbReference type="KEGG" id="mgl:MGL_3662"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3662"/>
    <dbReference type="InParanoid" id="A8QAA3"/>
    <dbReference type="OMA" id="IRERCGX"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="13">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP41981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="191" mass="20666" checksum="E0FD0A4FE74AF136" modified="2008-01-15" version="1">MLGRFASGLFAHASKAAQARAAVTVPTIGIASAVLYSSVQPVCLQPSYTRPSFEERMKPKAQPVVLTKIEKNSGNEESSETESTEEEESAFNERTGEINWDCPCLGGMADGPCGEEFKQAFSCFVFSEAEPKGIDCIDQFKHMQDCFRRHPEVYAEEIEADEAAAAEVATSDSSTETTPSTDEHASPASQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAF7</accession>
    <name>A8QAF7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729249.1">
        <property type="nucleotide sequence ID" value="XM_001729197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAF7"/>
    <dbReference type="STRING" id="425265.A8QAF7"/>
    <dbReference type="GeneID" id="5853555"/>
    <dbReference type="KEGG" id="mgl:MGL_3716"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3716"/>
    <dbReference type="InParanoid" id="A8QAF7"/>
    <dbReference type="OMA" id="IIKFVCP"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000003">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="527" mass="58691" checksum="179C93B213091FC9" modified="2008-01-15" version="1">MVISLLQRALCSKWPDARVYSFGSQDTQLYLPQGDIDLVVLSNVMNDMPREITLSEMAACLRSYQLAIHVQVLARAKVPIIKFVCPYGQFNVDISINQANGLQASKFVNGWLKKQPAIRPLVMVIKQFLQQRALSEVYTGGLGSYSVTLMVLSFLQLHPKLQRGEMSADKNLGTLLMEFLELYGKNYGYDECAISVRGRGKYVSKRQKGLYDYRKPFMLSIEDPHDPSSDVSRGSFAILSVRSALGGAFDILHAALCERANDLQNFRHRQQTLRNRQQKNTHMHFAPEDADNRLNMTSQIKEPESLLGSVLGVSREMIRRRNDVRYHIRLTLAKIKQLYDSGILQKQLYGSEAVPQLAASSTLGSKLDRRSANASASSSMDDDTSDASVVFLKSNPKRRKPQHDDDQDSSSESKYGSMRPKKRAAQDPWKSRPSLVTSDSDDEHLTSKDAPYVLVSSDSDDAASEPSHPPADPSPRPPTASTPVKSTSTGISIAGRAKRTKLSKQDRLQYWHNKALAPAQTTGNVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAI3</accession>
    <name>A8QAI3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_3742</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729275.1">
        <property type="nucleotide sequence ID" value="XM_001729223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAI3"/>
    <dbReference type="FunCoup" id="A8QAI3">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAI3"/>
    <dbReference type="GeneID" id="5853581"/>
    <dbReference type="KEGG" id="mgl:MGL_3742"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3742"/>
    <dbReference type="InParanoid" id="A8QAI3"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="408"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="585"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1094" mass="122043" checksum="6DCCB273BC544BC7" modified="2008-01-15" version="1">MQKPSNDAVNSTCSANAPCHEGTTARDRAEDDLAACLQVEIHRLRLLDAMPNHADVIVSVYLHGGISRRSCLVGESRTELEFEFGHVTKIMEIPRPYLSQAGSESVGVLLRSKRMFMGLGRRRIWGSSSNTNNASDASNGAKGSAARTNFGTQNEDTSRASVPQRGPLEFTVWLDNGKDRVCAGKCTYTLSQLDPVLACESVWLPILTEQGLLHSGLLVSLDLVRDEKHLKPIDQQDLEQYMNLLPANEPVGMVEENEDIVDEGISETSADGEDDGIGGVGVGDGVDDGGSMASPMGPPFSGMHALGLNNRDGDESWPIPTGDGGALIRRRPPVQRPRLEPKVSTASPIVDFVNLSDSDTLSVETGENRRVSWRPRARRLGLAKLRPRSYSASQSGIAQESDAKRVARLTPHDYAFWGNPGHGVQGIVMMEIKGARDLPRWQNLTHTSFDMDPFVVVSFNRKVFRTRVCRHTLNPDWREKLYFHVHSREMSYSVRCAVYDWDNISSNDYVGEVSLDISSLMNATKHSTANDTLSQDEGDENDASHMVTFDLPLQREGHDEDAKFGKGKARPRLQLDAVYRPYAVLRRRFWREMLRLYDTNDTGGIDIDELQTMLLSLGSTLTTETLLGFFNRFGKQPFGDELTMDEGVRVLEDELHKPWTERRACTLPPDMEAEETDDTPDVERVIRLRACPLCHMPRLSHADERDIVAHLALCSSQEGRAVDDIMVSNFVTATQARRKWYTNMFRTVSQGVYRIGANSANILVQDRISGQLVEEKMQVYVRLGIRLLYQGAKSRMEGARARRMLRNMSLKQGAKYDHPSSVRAIKPFVMFHGIDENEMVESVSSFATFNDFFCRRIRMELRPLAEPGNPGCMVSCADCRLMVFNRVDRAMQLWIKGRQFSVDKLLGGKVSQKTWPDTTSLALAIFRLAPQDYHRFHAPVDGVVGEMTRISGEYYTVNPMAIRSAIDVYGENTRVVIPISTRDFGDVYLVAIGAMMVGSIILTVSPQQHVKRGYELGYFKFGGSTLVLLVDGARIRWDDDLLINSNTCIETLVRVGMRIGVTPPATSVALSVSADRDVTNTRASNGCSTFQHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAU5</accession>
    <name>A8QAU5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3832</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 60S subunit of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729044.1">
        <property type="nucleotide sequence ID" value="XM_001728992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAU5"/>
    <dbReference type="FunCoup" id="A8QAU5">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAU5"/>
    <dbReference type="GeneID" id="5853351"/>
    <dbReference type="KEGG" id="mgl:MGL_3832"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3832"/>
    <dbReference type="InParanoid" id="A8QAU5"/>
    <dbReference type="OMA" id="CGRCSQL"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="39"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="166" mass="18720" checksum="E9F743D2BB389A48" modified="2008-01-15" version="1">MGVHLHVTLAKLQRLVGRKTGDCTRARFLSVVRTSLPAMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCEKHICRKCYARLPPRATNCRKRKCGHSSQLRAKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB98</accession>
    <name>A8QB98_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box protein Hrt3/FBXO9 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728899.1">
        <property type="nucleotide sequence ID" value="XM_001728847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB98"/>
    <dbReference type="STRING" id="425265.A8QB98"/>
    <dbReference type="GeneID" id="5853204"/>
    <dbReference type="KEGG" id="mgl:MGL_3893"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3893"/>
    <dbReference type="InParanoid" id="A8QB98"/>
    <dbReference type="OMA" id="DAFVHEP"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box protein Hrt3/FBXO9 C-terminal" evidence="2">
        <location>
            <begin position="170"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="343" mass="40121" checksum="6955DF01BCC0B8AC" modified="2008-01-15" version="1">MTKLFFMIDSHGRTETYEYMQMLDKMPCRPCFTPSQRHIIARSQELKAQNIEEHTVWPEHVGSSITTMYAADPEQALPVQRMPDEIWHSILWHVLLPRPVMQAWPPMLPENMSFDPPPEPWRRATGADYISIERLGRVCWRLRRLTAHPRLWRAIVQETYIPPLPELDARLACSWRDAFVHEPRVRMNGTYIATCQYIQQGMSEENVWVHVLHVVEFFRYLRFFPNGRCISWLTTERPADVVHRLEPGLRAKGCATGRWQCLSEEGEAPARRGATIVMHDLHDPTLPGYTFQMTLHMRPSPGRWHRLDMLEYASLNLRTGEVLPIPHKHARPFIFSRVLGYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBB9</accession>
    <name>A8QBB9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728904.1">
        <property type="nucleotide sequence ID" value="XM_001728852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBB9"/>
    <dbReference type="STRING" id="425265.A8QBB9"/>
    <dbReference type="GeneID" id="5853209"/>
    <dbReference type="KEGG" id="mgl:MGL_3898"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3898"/>
    <dbReference type="InParanoid" id="A8QBB9"/>
    <dbReference type="OMA" id="WAKFAPL"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="61"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="303" mass="34805" checksum="5B89606BDF2AADB1" modified="2008-01-15" version="1">MCQERGLSVPADSTKAVLADHLICEISPQKLQMPESTSKELPGLDLERLDLVDHEILPEKLEKQEKIGSGAFKDVYKGLYHVSRTRVIKVAICDLRDELTEMDIKELTFLRDLQHENIVRFIGISLPPRPGPVPCAIVSELCENGDLFDYIRNVSPPSDVEIFGILLQISRGLEYLHTRKPMIVHRDCKSTNVLITEHGVAKISDFGLARVRRSARAMIRSLVGTVNWQAVELWSARPQYNEKADVWSAAMTFWETLQWHQPEKRYPFQGMNEHQIYFNVRQKNLRYVQEIDDPICTQLTVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBV6</accession>
    <name>A8QBV6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728951.1">
        <property type="nucleotide sequence ID" value="XM_001728899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBV6"/>
    <dbReference type="STRING" id="425265.A8QBV6"/>
    <dbReference type="GeneID" id="5853257"/>
    <dbReference type="KEGG" id="mgl:MGL_3945"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3945"/>
    <dbReference type="InParanoid" id="A8QBV6"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728158" description="glucan 1,3-beta-glucosidase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="108"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="428" mass="49228" checksum="0057D1EE7A76A610" modified="2008-01-15" version="1">MIYHLVPWVLAAVAVAVTIVDAEQIRKPASGMKTLRRKDGLPRWDWTSSDKKAYGTNLGGLFLLERWMYEDWMVQQGGDDAWDEYTMSKNLGGKMKPILNDHFESWFTEDHMNQLQGAGINMLRIPIGYWPFLSTEETGEPYQNASHLEKLSQIMNWSQDRGMYVLLDIHGLPGSQNNDQSSGRNYTSNNDQQIVDWYSDENQKHSRKMVHNILNWLDAQPSKSVVAGITTVNEPKVFDNGDYHNKLREFYDFSLKALKPHGIALVAHHAFVADPYDYWHDYADRQERGTFVFDDHPYPAWFQNPEPTNRKDLIQNICNFRDQMSGFPAPVLYGEFSGITAVDDNDWVGHYVKTQLKVYGWSAGSTFLNFRMNFASNPVLSLPDHLQWKYSMLNLLDGLIPSRDQSKSVVDWTDSLSSRCGGNPHLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD00</accession>
    <name>A8QD00_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_4068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728733.1">
        <property type="nucleotide sequence ID" value="XM_001728681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD00"/>
    <dbReference type="FunCoup" id="A8QD00">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD00"/>
    <dbReference type="GeneID" id="5853059"/>
    <dbReference type="KEGG" id="mgl:MGL_4068"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4068"/>
    <dbReference type="InParanoid" id="A8QD00"/>
    <dbReference type="OMA" id="WCGIEFD"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="237" mass="26328" checksum="E8066B99794A4B22" modified="2008-01-15" version="1">MQVTLFIHAPGVHVLSERRFPKDIRKDELQQRVEIVTGIPPATQRLELVHGDGRVANCASFPPDVAILQAWGASDGMQIQVHDKRGPLLADEESVTKYELSDEQYAARHDTLRAYKQAHGLGRFASNTGTAGAAKVTDKHQLDDQHKDGVECGARCMVDTGDGFERRGTVRFIGPTKFAPGFWVGVEFDEPVGKNDGSVQGERYFETRMHYGGFVRLAHVHVGEQYASEQIDDELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDR4</accession>
    <name>A8QDR4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_4230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000023">
        <property type="protein sequence ID" value="EDP41417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728631.1">
        <property type="nucleotide sequence ID" value="XM_001728579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDR4"/>
    <dbReference type="STRING" id="425265.A8QDR4"/>
    <dbReference type="GeneID" id="5852940"/>
    <dbReference type="KEGG" id="mgl:MGL_4230"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4230"/>
    <dbReference type="InParanoid" id="A8QDR4"/>
    <dbReference type="OMA" id="EMGIVHS"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32038" checksum="860D00D0742F95A3" modified="2008-01-15" version="1">MKSYVPCATNTFRKARAWPRWAAFYSSAPPASQVYCGKDDTPLVRTEYLSDKRIWILHMLAQETPDNRLTHTFIEHGLLPALRDVRMHWASWVKESNTADGAALVTTAPMDNKIFSNGLDLINALRDPHFFNDHLNKLFRELLTFPIPTVASVGGHAFAAGFTLALAHDYRVMNSERGYLCMNEIEFGAPIPKGMLGVITSVARQPSLQRKIVLEGHRFTAPEALEQGLIDATSKGQQGTLDVAVALADRLRSRCAKNAWQAIRELLKEEAILSQYEPPKAHITVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QE72</accession>
    <name>A8QE72_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000028">
        <property type="protein sequence ID" value="EDP41389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728603.1">
        <property type="nucleotide sequence ID" value="XM_001728551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QE72"/>
    <dbReference type="FunCoup" id="A8QE72">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="GeneID" id="5852911"/>
    <dbReference type="KEGG" id="mgl:MGL_4258"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4258"/>
    <dbReference type="InParanoid" id="A8QE72"/>
    <dbReference type="OMA" id="HITIHEE"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="217"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43079" checksum="8632E679BBE272E8" modified="2008-01-15" version="1">MADWYHHQHGYIMRHDYMTNGGDYQTPDSGLLYFAHTKANHTAKTLKGINENATLPFEPGKMYRLRLINMSAASVFDFWLEGHDMEVIEVDGVDVERYPIESVQVAIGQRYSVLVKARNETDKNWRIHANMEGGTFPKVGSLKLNLTGTLTYGQKDAKMGDGKKNRRTDVKPFDDTKLVPVKKIESKEPDMRVSLEVKMKEGRKHGKPMGLINGTTYVAPKTPTMLTMTAKNTTNPMDAGTYGRNVNAVTAPYNSMVEMTILNLSDDVHPFHMHGTKFQVVHRAYGTDGTKPQVPKVEEQENPVRRDTVAVDGFGSVTIRFLASNPGAWFMHCHMDWHLSAGLAMVMVQAPEKAKEVLKVPSYVEEQCRVWKKQSDHKVRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR66</accession>
    <name>A8PR66_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732841.1">
        <property type="nucleotide sequence ID" value="XM_001732789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR66"/>
    <dbReference type="GeneID" id="5857147"/>
    <dbReference type="KEGG" id="mgl:MGL_0616"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0616"/>
    <dbReference type="InParanoid" id="A8PR66"/>
    <dbReference type="OMA" id="RDEAQWF"/>
    <dbReference type="OrthoDB" id="3003917at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727915" description="DNA replication regulator Sld3 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="383" mass="42775" checksum="6C1DC0F017FC39A4" modified="2008-01-15" version="1">MAAVHCREVQLQLLIVAWLLPHVPKVPSTHAQYDASSYSKRRKHSKPKSWHAPRIPFADVAMERLPTTNEPKELSIEMTYDSLRALYEALADQLCLLQFSATLTPCAWVFGSGARVKTLQDERDEAQWFCADVFGSTYASSLPKEYEILRFKCFGPGLTETTPTRRRRMERTSSAPLASMPVEPSPARESTSVSGSVHENHPILDAERSSQRRLLTTLRSTNEVHMSRRLVRTHSYTPQSTTLHSPMSTPTAAAPSTSMRHHKRKAPANRWASVPAKTLVMETPRHVRQRTVSFPSVAGGLLDKTQHDRAINESNANTHANDVDDEDDSPPPSPSTARITTRTSSVPDLISRPPTPDSDSDVDLLIPETQKAARKRDPLALFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRF7</accession>
    <name>A8PRF7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_0042</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732267.1">
        <property type="nucleotide sequence ID" value="XM_001732215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRF7"/>
    <dbReference type="STRING" id="425265.A8PRF7"/>
    <dbReference type="GeneID" id="5856573"/>
    <dbReference type="KEGG" id="mgl:MGL_0042"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0042"/>
    <dbReference type="InParanoid" id="A8PRF7"/>
    <dbReference type="OMA" id="HELRWNR"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP45053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="427" mass="47440" checksum="B540694C6D6A39C6" modified="2008-01-15" version="1">MSSWLDALQAILGATALVWYVVLWTVCLIGYSVAKELFECSWPRSPLSSANPTTTDVPGVSILRPLAGLDCNLFTNLCSTFEQQYPTDRFEIILSVRSEYDQALNIARQVKERYPHISSTIIVGDVEASVNPKINNLVRSYAAAVFDIIWVVDSQVWLSPQALSRAVDALTLRPVSPVPQWMHRKPNGDRVGLVHHVPLGVLPADTLASHVERVFLSTTHAKMYLAINAVAIDSCVMGKSNMYRKSDLECVPDSFFQYKHDIPGIGSRAFDDESTRTGGVTDNAPIAQSLDVVHGNARALARYGIYLAEDNMLAMSLWRPPLKLAHRISPGDVAQVAVGDIQTLGEYAKRRMRWIRVRRHMVPLATYLEPFTESLVAGGLAWYGLRMYVLRGWILGSSIQTWIAFSLFFPPTSNGVVLGRYECARGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRL9</accession>
    <name>A8PRL9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0082</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732307.1">
        <property type="nucleotide sequence ID" value="XM_001732255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRL9"/>
    <dbReference type="STRING" id="425265.A8PRL9"/>
    <dbReference type="GeneID" id="5856613"/>
    <dbReference type="KEGG" id="mgl:MGL_0082"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0082"/>
    <dbReference type="InParanoid" id="A8PRL9"/>
    <dbReference type="OMA" id="AYEPITW"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="68"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="219" mass="23739" checksum="88EABC3485EF4162" modified="2008-01-15" version="1">MFSKIASTAALRGASRMFSTARAVPMARATTPLALAAAAGVAGLSLYSLPQLQLEGPRTIAGEYKTAGERSFIMIKPDGVSRQIVGKIIDRFESRGYKLVAIKSVVPSEQLAKEHYADLSARPFYPSLVKYITQGTPVVAMVWEGKDVIRQGRRMVGATNPLEADPGSVRGQYAVSVGRNIIHASDGFDSATKEIGLWFNESEIAQYEPCTWPQIMADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRR0</accession>
    <name>A8PRR0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732333.1">
        <property type="nucleotide sequence ID" value="XM_001732281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRR0"/>
    <dbReference type="GeneID" id="5856639"/>
    <dbReference type="KEGG" id="mgl:MGL_0108"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0108"/>
    <dbReference type="InParanoid" id="A8PRR0"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="554"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="700" mass="76182" checksum="701656724D385EE4" modified="2008-01-15" version="1">MGTDMGGVHADGLRHASPCPFPLMLDPEEEDKGRESVDLPPLRSNSVEDTRCYWAICKYKDSKDSSLLFVYLDPRAYKKIGHLMYQSSLMDFVQPSEQPRVRDHLRTIMLSQTLFGSVMQCRFVSLSSMYAYLRGINPPAYNTTDIIVSWLNEDLALCFFHAVDDATCACGLDPGTFNRDEVYRLWDALSAASDPQPKGPLSNVFQILSTDSPRTILMSWPPPGLYNARDFASLVEGASSPDGATCTQRLRASHALHTQYHTFTVASVLVPCASVLLACFQITDEQALPPGRRANAAPDQQSKLQFASAVNASKKCSSCGKTDSPEWRRGPSGQKTVSTKLFVLSSLTLQLCNACGLRFSRSLTSRRRRDNNASLSINQETDEPAMVPRSRGAGGGSRPGTHRRNHRRVKKSKGQDETRVDELSEYDRRLAHVLASLPDDQLAVDGFHTPFANKLPPKMPPLQSFAPLHSAPASPGPLMSPTTRIMFQSPPPHSSMPSPHVPPCLPLSVSHSSYQNTNPTPDAAVSMDVPISASVPTTPTAPTTSFSQAFSVIPHSGTSQHSHLPPTSTASPVHRSFSRARASSDSTPHPIPNTTPNISSMFVPKHELDTSSLHAPTPSLPLSSMIIAPKSPMHSNFQPTDSTAVATSFSDAVTTTAAVSSLQNHLSPQWSSESTAKDQNTTLLDLENPSLTKQVPLCEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRX6</accession>
    <name>A8PRX6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732375.1">
        <property type="nucleotide sequence ID" value="XM_001732323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRX6"/>
    <dbReference type="FunCoup" id="A8PRX6">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRX6"/>
    <dbReference type="GeneID" id="5856681"/>
    <dbReference type="KEGG" id="mgl:MGL_0150"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0150"/>
    <dbReference type="InParanoid" id="A8PRX6"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="7">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="7">
        <location>
            <begin position="191"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="261" mass="28545" checksum="DF34D9F2E18EA1BD" modified="2008-01-15" version="1">MDSSHVALSAVELRADGFEEYRCDRPMSIGMAITSLTKVLRSANNNDILNMRKSDNADSLHLVFEGTSSDRIGEFDLKLMDIDTEHLGIPDTEYDAVVKLSSNEFARICRDLSNVGESVKITITKEGVTFSTEGEIGDARMTLKQGSGSNARLEDDDDMDPLDDEDGDRMSKKRKMSGAGSSSGTGAMVPVEIQLEKAVALTFSVQYLVNFTKAAPLASAVTLHMADKVPLLVEFAFENGHVRYYLAPKLAEVCHAPRVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSJ2</accession>
    <name>A8PSJ2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732492.1">
        <property type="nucleotide sequence ID" value="XM_001732440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSJ2"/>
    <dbReference type="GeneID" id="5856798"/>
    <dbReference type="KEGG" id="mgl:MGL_0267"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0267"/>
    <dbReference type="InParanoid" id="A8PSJ2"/>
    <dbReference type="OMA" id="DHTPQLY"/>
    <dbReference type="OrthoDB" id="2555328at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="604" mass="65586" checksum="7F1D06C9FCF45A9A" modified="2008-01-15" version="1">MGTTPRAVLLKGPTLNSKVFMTAMPERHEDLVSKACELFKVPADHTPQLYVACQASVGTMHSEQRGALLLADAMPFLRDRELITLRWVPSDSFRREKEGHVQWDPRLDDTRPLTMASHVRPQPMPLWRGPQARAMHVARVLERERTNVPSSQDDLPRKPLARSDFYPTKLVLTSEPSSENSFDSPSTRAFEHTSDQSNQRTEQASQQAPGHVLEQTSEEVLARASKEVSHQTLEQASEQAPESPSKKPSVLPYSMPMSPPPSSPTASPSHEPVRASPPSSPTPHRGPNNATPLQWDSSPDSDDESQIEPTRRRKHESRKSSFGAWCARLNPFARSDDEGSTRRSSPEPCRQNLEPSSSATTQNTSSDVTPDSESPEDTAGKTAPSPSTTAASSSSTASSMPVATASTSAPTPVLAPMPGATLTPSDLYVSGTAAYDIMTQVLLALREHARNVHCKIPQEFCARRTGLSSGLGLCVAKRALSEEKPLQQFAEALNEYLDACMSKHGVGVRSEVMTLRAFVFKLMGELQRTSAPASDSTDALESLPPKERAAVSKASEVPSRRRGGSRKRATDTGAGAATGSSSVSDEPLAKRTRRASRRTSAYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSY4</accession>
    <name>A8PSY4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732562.1">
        <property type="nucleotide sequence ID" value="XM_001732510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSY4"/>
    <dbReference type="FunCoup" id="A8PSY4">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSY4"/>
    <dbReference type="GeneID" id="5856868"/>
    <dbReference type="KEGG" id="mgl:MGL_0337"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0337"/>
    <dbReference type="InParanoid" id="A8PSY4"/>
    <dbReference type="OMA" id="RVAKGMH"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="78"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="426" mass="47792" checksum="AE3C3C314FFAE226" modified="2008-01-15" version="1">MSASSVAMFSSSALRRHPASLLPRIVHNPSLTDLIRYPVTRDMVAYIAKQASNVIQCSPESSDGTNAVRTQNLPSLEAFIMMLVEKSNVQVPTLLSTLVYLDRLKNRLPRIAKGMPCTRHRVFLASLIVAAKYLNDSSPKNKHWMRYCVFFSQAEVNLMEKQLLYLLDYDLRIEEDEIMFHFSPFFRRFETRADAGRREMFLRGCDAGRECDRYARASERRVALRNLPASQVPCWNNHPKSQPSTPKRVSPPRAQAARPSKGLLTPTATLKAMSLHVRNSETTRSASSISEAELTDDNGSATSSPDEAHDEEEPTFAAVRHYDQARVTTSLPRSSSTAMMASMEQRQMYTSMRSSQGMAASYPYPSDKSNTCQDPRSVESTPARNGKTARAIQVASDGMQRYLTNVIPSGIRRSNSRMTLRSNTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT27</accession>
    <name>A8PT27_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732582.1">
        <property type="nucleotide sequence ID" value="XM_001732530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT27"/>
    <dbReference type="STRING" id="425265.A8PT27"/>
    <dbReference type="GeneID" id="5856888"/>
    <dbReference type="KEGG" id="mgl:MGL_0357"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0357"/>
    <dbReference type="InParanoid" id="A8PT27"/>
    <dbReference type="OMA" id="FRIVDAY"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="499" mass="55783" checksum="E9D3264D93A1F19B" modified="2008-01-15" version="1">MASNVLSRILQRTRVSTFDPAIQQVYHTPLAHSVRGDWGGKRPLPSSWQAMADAPAPMPYAGALRYLTIHDIDNKHGMTDWNESEREPLFRKRWHEAGARLSDKPWRDVLGVSVMGDDDVNTSLGPHPRIAYDPATMSDTKSLPSNVVWGTHHERFADTGDVLPNYHAMDERTFQRFLQNLRRQRTKFRAALKQQRNEAAIASQMDQLAQAAAQRSVTQAEWDEAAQPPKNGVDVDMWTEARLPHAPQSAADYLKQSARDRYDAPNSSTIMSPAHAKAAHPLRGLQYSQPDSVYSFVLNEPVHGRAMHRVEDSRRNRFFMGSDAALAVAVGGHVGHLPLQHRHGLDPIDYTRTRPKRGESYFRVLHAWIDMAPTVANARRAPPRTDSDPMLGAVRTQVMALRRPGEHGSVYEAPPTPGSPRWIDDPDAVPSSLGGSLRGASSPEAGSLFGSLARHGRSAQMPRQGTKRQRMQKRQREAPSNVQRDIQMLNNIKNLLSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTD1</accession>
    <name>A8PTD1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732630.1">
        <property type="nucleotide sequence ID" value="XM_001732578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTD1"/>
    <dbReference type="STRING" id="425265.A8PTD1"/>
    <dbReference type="GeneID" id="5856936"/>
    <dbReference type="KEGG" id="mgl:MGL_0405"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0405"/>
    <dbReference type="InParanoid" id="A8PTD1"/>
    <dbReference type="OMA" id="MEREQMT"/>
    <dbReference type="OrthoDB" id="5582002at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="420" mass="47190" checksum="D89FA0BF371164EF" modified="2008-01-15" version="1">MPHIDAHESRTSLLEDKESSLLHNRQSKHTRTALDADHDLEAPPHHEWDMRSQDDSDDESQSDEDFDVYRDFLNYGQSGDALPLYDNMDNQQVTSNRSSHFGSVPPLASRPKSQPLLQIPTHLQDTSSAALFDTRYANDSLVVGNDTKPYGTLLGHSNSSFELADIAPPGAEYSTTELAEMTRSHRRKVWRQKQARTFDHWLHGQHLMCGWLGRGTALMILFVFFIMLILILYFVIPRVPTVHLVTRNALTPASKKSDMVLSGAPTGFKMNGTMNVRLDNNDGWVPSHLLSLHTDVTLSSTNVKIGSGDVHSQWIPGRKVTQVQVPISFSHKSLNVTGDDTQQTMQKACAHLYRGVQRPSEYDWCFLLTLPHLHGPFPLFPTVAGISLQIDMQMEIGGILGKHKSKLNLQDIDCPWELPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTQ3</accession>
    <name>A8PTQ3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0461</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732686.1">
        <property type="nucleotide sequence ID" value="XM_001732634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTQ3"/>
    <dbReference type="FunCoup" id="A8PTQ3">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTQ3"/>
    <dbReference type="GeneID" id="5856992"/>
    <dbReference type="KEGG" id="mgl:MGL_0461"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0461"/>
    <dbReference type="InParanoid" id="A8PTQ3"/>
    <dbReference type="OMA" id="YEFKWER"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="506"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="630" mass="72334" checksum="E944BCE94BF12CDE" modified="2008-01-15" version="1">MSCPPIPSKHEFAGVPLFQRLPKLPELEGTDPARAPQDAFRLAIADQLSRSIGTPLKDTFLAVATGGKECDYKVVLPRFRLPTKVDELQEKVLTEFQPNEYIERVTKQGPAVLYHVNVKTLIPLVLSTVHALTYGDGAATEGDSGKKLPSYGSNYSGKGKLCLVEFSSPNIAKPFHAGHLRSTIIGAFLANLYEANGWDVKRLNYLGDWGKQFGLLALGWRRFGDEQKLQENPVQHLFDVYVEINKLASEEGGKGEQIHDEAREFFKGMEDGKEENLLEWERFRDLSIEKYKETYARLNVHFDEYRGESKVRKHHIEDTLSKLRTMDFVSREENGALLADLSKFKLEKAVVERKDGTPLYLTRDIPEAEQRYEQYKFDKMIYVISSQQDLHCAQFFKILELLGHPWAQKESEGLLHINFGMVQGMSTRKGTVVFLDHILDETKEQMHDVMRKNEVKYAQLEDPERTADIVGMTAIKIQDMAGKRINNYTFDWKRMFSFEGDTGPYLQYNHVRLCSMERMNAEDGLVLPKEDLDFETMRTERLQVPEALEIVWLLAQWPDVVRTASRDHQASTIVTFCFKLTHAISSAWEKLIVKNQERDDALVRLWLYRCAKDVLSSALRLLTVTPLERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTY0</accession>
    <name>A8PTY0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732721.1">
        <property type="nucleotide sequence ID" value="XM_001732669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTY0"/>
    <dbReference type="GeneID" id="5857027"/>
    <dbReference type="KEGG" id="mgl:MGL_0496"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0496"/>
    <dbReference type="InParanoid" id="A8PTY0"/>
    <dbReference type="OMA" id="WFDPISF"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="137"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="966"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="973"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1269" mass="138353" checksum="ED5B295A8F3E4D02" modified="2008-01-15" version="1">MDEAQNDRDVESYAKAEASSSDLSLLPSPPILSMSSSMVVPVAIAVLSFVVMRLGILAMLCVFALSFVFLCHPVVREYLELAFPGDHSAASQARHEHETAQVLRGRAHDIVSLRGNQVNSSPDKSKKGIRMSIDLLPATLQPEIRHILRLVRRDFVQSWFDPISFGSASFPTEAISCMEHVLAQISLRLEQYDRATVATELSLTALSVIVTAMQNMRSEDAPAPGLWDNASARIESLRTSMYTLLSQSLPEEERRSSMVVELLSEVLSKQLWSALQTYSDPDVINGYILQYGKRTSSSMHVSREEEPVFVHGADSSSSGVTSKDPSSASPLLSGEPLKPNHAPEAPIKNLDTHPDSTLTQLDPKTTSPSELRSSPLPTRARTSPKASTKSSGVQDLLIDLESEHASQESSNCGQSLPSSTLPDPLEDVLSELRESRSEQDLDVHAPGHGHRSSDDVIPNETPASCDDSISNRSLLSKSSPGPDRSPRPAHSLSNNSLSYPNKTLLQTESRDVADMPEHSTSLPPSPSDTHVALPSSAAKRNERSKEKGPVDFFSSPWAAPMNVPSQVSEPPLPPSIEDSRVMKESYQVRYPKKVQEVLSRKDSDVYDAWGSYLAAIDPTAEPSEGAVLIQLHANLEALDAAATHESSSPALYTSDVRAILQTSLPMLPKQNATSELRSAMESILQHDMIEPPMLVPLRNALLRRMQALYDMFLASVRGKPQQSSEPSSLNTASCANSNTYEPRRKRPQATMSSINVPRNISVVDLSANAEPEHVVDSRTMQVLVTVEEESDDGSGGYAVIRTWPQFEALHVDLVRMYERRPVGSGMSGPPALPSIKGLTSSVACDAIRRYLLELLAPSHAQDGMAWYSSTQAVHRFLDKTRATDEESRVWNNLFMPGLGGMGRTFATGFAGAAGSARRGIGQLAPTPSRAGRIFGLRPDMTETRPAEAPAPNTEKHGVDKGYGLAFVPRKKKNDTERVDEIPDGHAAGRGDDVPLKHDLVSKNHADSVSDSYENKPYVETEPHPSCPTSDSKATSAAPSLSLSKETHVPYETRKRGPKAEGETASNASSSKTSPATISSEPCPEETPSLHDINVLLTAVFAVTREALNMHKAWTLQRGMLRIIEQYIRTTYVSTVSKTLSYFASKLSLNEQASWLKYLRESWWPNDVWNTETTPIRTEEEIHTRYQEARKVVLSYAPPQAAYALGIGGKQAVCDALTTVHKVVTDPMVSLDLHLALLLRVIDLAIGTASAPASGKNRARSNRSAAAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUD3</accession>
    <name>A8PUD3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Endoplasmic oxidoreductin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_0661</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732068.1">
        <property type="nucleotide sequence ID" value="XM_001732016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUD3"/>
    <dbReference type="FunCoup" id="A8PUD3">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUD3"/>
    <dbReference type="GeneID" id="5856364"/>
    <dbReference type="KEGG" id="mgl:MGL_0661"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0661"/>
    <dbReference type="InParanoid" id="A8PUD3"/>
    <dbReference type="OMA" id="CYKDRLH"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727085" description="Endoplasmic oxidoreductin" evidence="19">
        <location>
            <begin position="24"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="423"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP44854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="62252" checksum="0D40C7AA012C7916" modified="2008-01-15" version="1">MRIYMFSRSLFACIAATLVAVLASSLEGGLEPTEETNTGLLQEVLDPLGQGAKDGSLETKPICRPTGQIQDACSDYESVEEWNSQYMFERLDNLRKTKYFRYFVVDLFRECPFWKEEGICMNRACTVERMNETNMPDEFRSYRLSQLERTAEDMDQDADKTRFCQLDDENMSEDAIFVDLLKNPERFTGYSGASANRVWRSIYEENCFGGIKWTEPPRPESEGGAGFISQQRMIGTIKGVPATLLNPDHPPTKGGSLESLIDSVKAPVDPASTEQCLEKRVFYRVISGLHASISIHICNEYLDPVTKQWGPNLECFISRISQHPERLQNVYFDYVLMMRALSKAGEYLDKFSLRAGDEIHDNESRKQLNELLQIARKNRPSFDEHKLFELNDNPEHNRETLALKEDFRLHFRNISRIMDCVGCDKCRLWGKVQVTGIGTALRLLFAFEAADEKPHIVLGRNEIVALINTAHRISESIRAVETFRKLYHDTMSSASSEHADHTSARQERELPPISYMQKTWNVFESAMAGIYELFATDDWAEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUJ2</accession>
    <name>A8PUJ2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AmmeMemoRadiSam system protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732105.1">
        <property type="nucleotide sequence ID" value="XM_001732053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUJ2"/>
    <dbReference type="FunCoup" id="A8PUJ2">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUJ2"/>
    <dbReference type="GeneID" id="5856411"/>
    <dbReference type="KEGG" id="mgl:MGL_0698"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0698"/>
    <dbReference type="InParanoid" id="A8PUJ2"/>
    <dbReference type="OMA" id="CASHAFQ"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22842" checksum="F075A41C0664BB03" modified="2008-01-15" version="1">MSEEVDEAEHSIEMHLPYIYKVWGERDVKIVPVLVGHLPEQMNFAYALCFAQYFADPRTLFVISSDFCHWGSRFQYTWYQPTSTSKGIMLSSANKSCIEPKMPIYQSIQNLDAEGMSAISFNKHGSRRARQAFAMHLTKTGNTICGRNPILLLLTILEILEDRGAMFECRFTHYKQSNACCHVQDSSVSYATAYIRSSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUK3</accession>
    <name>A8PUK3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732112.1">
        <property type="nucleotide sequence ID" value="XM_001732060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUK3"/>
    <dbReference type="GeneID" id="5856418"/>
    <dbReference type="KEGG" id="mgl:MGL_0705"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0705"/>
    <dbReference type="InParanoid" id="A8PUK3"/>
    <dbReference type="OMA" id="QQASWGN"/>
    <dbReference type="OrthoDB" id="2553689at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="198" mass="21431" checksum="CDB76FF723BFC51F" modified="2008-01-15" version="1">MASIHAQIVPEFAVDPRLFEPISLQNETWSYLQENQKRATPTQTTAATPSNPSGVDKNNTSNHLESTGSASPGATATLQADTSKGHCEMSNDLSVNQQASWDEYVVSTCCTSSDYAECWYRVQASVDAKLACVIPKCQDLQTNDPDKMLGFKPLSGSNGQGKYQNLFPILILSSALRHAIPHFLVVSISLGVSLLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUN5</accession>
    <name>A8PUN5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0728</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732135.1">
        <property type="nucleotide sequence ID" value="XM_001732083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUN5"/>
    <dbReference type="FunCoup" id="A8PUN5">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUN5"/>
    <dbReference type="GeneID" id="5856441"/>
    <dbReference type="KEGG" id="mgl:MGL_0728"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0728"/>
    <dbReference type="InParanoid" id="A8PUN5"/>
    <dbReference type="OMA" id="RTMCTYL"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="30"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="344" mass="36514" checksum="82AC2630FAD14D93" modified="2008-01-15" version="1">MVNFENLKLVALGNPLLDMQVRDGQDVLQKYGLKPNDAVLASPEQLSIYEHLVENYQVTYVAGGAAQNTARCAQYALPEGSTAYLGCVGNDDLAQQLRAANEREGLQSVYQVVNDTPTGSCAVVITGHDRSLCTNLGAAEKFDKSHLDSQEAKAAIEAAKFFYIGGFFLTHGVESALIVAKHAKETGKPFAFNLSAPFIPQFFKSQVDQVMPYAELVIGNESEAEAWAKASGMETSDLSSIAQKIADSPSEVSKPRTVLITHGAESTIRAVQGQSSVITHPTPKIDAANIVDTNGAGDAFAGGVIAGLIMGKSMEEAVDVGHRLGGMCIGQVGPVLKFPKENVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV86</accession>
    <name>A8PV86_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731554.1">
        <property type="nucleotide sequence ID" value="XM_001731502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV86"/>
    <dbReference type="FunCoup" id="A8PV86">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PV86"/>
    <dbReference type="GeneID" id="5855876"/>
    <dbReference type="KEGG" id="mgl:MGL_0822"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0822"/>
    <dbReference type="InParanoid" id="A8PV86"/>
    <dbReference type="OMA" id="AMDWRSD"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="37885" checksum="FF4A06DA1697D660" modified="2008-01-15" version="1">MSVSMSWGVSALARMRGALRVPHVGARRLHITPVTESKNRGRARKSPKTLLRLYAEGKLKGSEAVKAAALLEAQNAEQAGTVKETAAEEEVSDTLSLSDARHVIRSVEAARPRNAYELHVVTSVPPNQTNAFRGRISFPKDPRIKGETVLVFAEQGSETADAAQQAAAQLEASGSSMRLVIGGNDMIADTVAGRVPSFSRVLCTSGLLPSMSRSLARALGPKGLMPSAKRGTVVDDAEGMQQAIEQLVTGVDWRGDRVGVVRAAVGRISFSDAELRANVQAFLDAIITKAASGLAGTKVSANVVASYLRDTSSKDAQGNMIQRRSPGSMKKALSIVQQVHLSSTQGPGIRLRLDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVH0</accession>
    <name>A8PVH0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">I/LWEQ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731595.1">
        <property type="nucleotide sequence ID" value="XM_001731543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVH0"/>
    <dbReference type="FunCoup" id="A8PVH0">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVH0"/>
    <dbReference type="GeneID" id="5855901"/>
    <dbReference type="KEGG" id="mgl:MGL_0863"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0863"/>
    <dbReference type="InParanoid" id="A8PVH0"/>
    <dbReference type="OMA" id="FQMSVEM"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="I/LWEQ" evidence="5">
        <location>
            <begin position="679"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="291"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="881"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="929" mass="105305" checksum="AF6CA8952404DE7A" modified="2008-01-15" version="1">MSGNTPRNYGQLIQAYVSFIHAKLRFHRVHKEFNGLFEYEEYVSLKNIDNPDEGYETIIELMNLQDRIEKFQHLVFSTLRGRANECQISSLVPLVKESYGIYKFLTSMLRAMHRRTDAMDALEPLRGRYQHQHYELRRFYFECASLKYLTSLINVPRLNAEPPNLLATPDAPELPAREPAQQAPREPSPPAEQSPSQAEIEEQARLLKEFEDKQRLLKEREADEARRNEERAAQREREFAEQQAAQAEQQRLAQEQLLRSQEMHQIHGRAAELERDLLFMRGQYERDQLMLQQYDMRVKALEMELSAAGQNVHAQMAGKDDMITQLQEQVDTWRKKYEALAKLYSQLRNEHLELLSKYKQVQLKAGSAQEAINKMERMERDVKAKNLEMSDMIRERDRARLELDRARGGEREEVERLKRELRFAEERAEDAVQARGTEVSSIMSRMNAQISELEEALASHKAQLEAKDAEALILQEGMDSTIRQMNDMRVDQGTSDDALNAQIDTIILDNSKKLSAILDSILQACADKLDVALYELETPASTTMQGVTATPEYVLSLIEKAQASANEFAAVFSLFVEQQLGDDHVNVIKCANQLAQAASDSVVNVKGILRFCRNEDAMERLTSVAVDAGHVLLRFFLNVQSYRLASMSAQQRSHVAMQQNAQANDALGRLADGVQALIGQRAPQGELGDMIEQEMMSAANTIEQATLRLQALLARDKTSNRYSATELKVHDTILEAAMAIMRAIGGLIRASTESQEEIVARGRGTSSAHQFYKKNNRWTEGLISAARAVAFASTMLIETADGVIMSTHSLEQLIVASNEVSSATVQLVAASRVKSEFMSQTQERLERAAKAVTDACRSLVRQVQMITDRQSGTDDLDFSRMATHEFKVREMEQQVEVLKLEKELSQARRVLGAMRRAGYHATEEDQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVZ0</accession>
    <name>A8PVZ0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0988</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731720.1">
        <property type="nucleotide sequence ID" value="XM_001731668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVZ0"/>
    <dbReference type="FunCoup" id="A8PVZ0">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVZ0"/>
    <dbReference type="GeneID" id="5856025"/>
    <dbReference type="KEGG" id="mgl:MGL_0988"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0988"/>
    <dbReference type="InParanoid" id="A8PVZ0"/>
    <dbReference type="OMA" id="FNNTCIQ"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12565">
        <property type="entry name" value="RRM1_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12316">
        <property type="entry name" value="RRM3_RBM19_RRM2_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="287"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="468"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="587"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="686"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="801"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="824" mass="91131" checksum="546EAE6CABC6BE46" modified="2008-01-15" version="1">MSRVIVKGLPPYLSDSRLREHFAQKGKVTDVKLMRRPDGTSRRFGFVGYRTEAEAEDARTYFDRTYIDTSRISVALAKQIGDQDLLAEKTARLSKSTKADEKDQRAKSTQKKDDQTEKKAPKASEKGATFEEFMSVMAPKLKRKSWMNNDDLTRANEAEQIREEKPMTKRRKSTTKPAQADPSLTARESDGETPKDNAASNEALSDLEYMRRRMRHKVAGGEGPSPAFEQSDSDSSDSEGDQDQDQDDEEDDEDDERDKEEAARRKATLEEQKRRDEENVDTIMESARLFVRNLPYSATEDELASFFSSYGTVEQVHIPLDAQSKASKGLAFVKFVDPSHALLAFRGKDGAIFQGRLLHVLPAVSPVPKPQSSGSLKQKRHEAKKAMAGKDFQWGMLYMNSDAVASSISERFDVPKATLLGADEVAGVSPAVRLALAETRIIQETKQFFADHGMNLDALERVKTRTDDTILVKNIPYGTGADEIRSLFARFGDVARVLMPPSNTIAVVEMPIVNEARVAFRALAYKRFKDAVLYLEKAPTGFLPPRGSGAPHAETIASVQGKRAPESSRSLLGADTNDTAAVAAADGTLYIKNLSFATTSERLADAFRALAGFVFARVQTKPDAKQPMVRLSMGYGFVGFTSAEHAIHAQKAMDQYVLDGHTLSVSLARRGRDADDDAPVQRAPSAKMLVKNVPFEATKKDIRELFGAHGQLKSVRVPKQVHGRTRGFAFVEFVSRREAENAMAALRHTHLLGRHLVLEWAGDAEGTAGVDELREKTRHAYVGESDRPRALGQRAKIRMGAEQVAEAVAQQAKKSDDDGDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW26</accession>
    <name>A8PW26_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731744.1">
        <property type="nucleotide sequence ID" value="XM_001731692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW26"/>
    <dbReference type="FunCoup" id="A8PW26">
        <property type="interactions" value="603"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW26"/>
    <dbReference type="GeneID" id="5856049"/>
    <dbReference type="KEGG" id="mgl:MGL_1012"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1012"/>
    <dbReference type="InParanoid" id="A8PW26"/>
    <dbReference type="OMA" id="RYNINEY"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="226"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="347" mass="38562" checksum="1E3081EA7C270793" modified="2008-01-15" version="1">MKLTDATSPRAWQVKRVMLLLQRGQLGQAQTLAMDIYRADPSDTGAIMLGARILLANNDVQKALQQSQMALRLDPDMQQAKQFLRKCKALSSLKDEANAAFKTNRTDQALAKYAELLQVADQNVEVDGEAKKFKSVIHSNRAILLSKIGRYNEAISDCTRALQLDASFTKPLKTRARAYQLNEQYEEAVRDFKRAVDASAGTAEQDTLRREARRAEVDLKRSKKLDYYKLLGVPKTATEAEIKKAFRKESLKHHPDKGGDEEKFKQCNEAYGVLSDEQKRRRYDSGVDDMDDMDLGGGFGGMSSGFGGMGGMGGVNLADLFGAQFANFDMGPGTTHFYGPQTSFRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW41</accession>
    <name>A8PW41_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731753.1">
        <property type="nucleotide sequence ID" value="XM_001731701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW41"/>
    <dbReference type="FunCoup" id="A8PW41">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW41"/>
    <dbReference type="GeneID" id="5856058"/>
    <dbReference type="KEGG" id="mgl:MGL_1021"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1021"/>
    <dbReference type="InParanoid" id="A8PW41"/>
    <dbReference type="OMA" id="AYSEPQT"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="117"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="421" mass="45792" checksum="6ED9F7A594030997" modified="2008-01-15" version="1">MIPSSRSWRPSYATAGTLKRMVAPSAAARAPKPISRIVVPTRPLHAAPAPPPTPATSAAAPEHKPMKIVTAYAFAAKPREMQEEEEEESNESSAAAQEDLPRKQRRSESRAPLRGGIIANSELERWRKKMLKGGDAGEDALFVTKSADQSTVLLGVADGVGGWSDSGIDPAHYSNALLYSAMKYAESHPTFPLPKVILEHAFEQVSKNPDIQAGSSTACLLRLDAVQGKASCVNLGDSGYLHLRPDPKSPEGRMQVVNSSVPQLYGFNCPYQLAKVPASMAQPGSLTNYPDDAAVQEFDLQRGDMVLVMTDGFLDNVHCKLPPRDALTPDAPRRPELLQLVDMLQDKHREHWSACKKQGATLADEKQDFANVMASTLMQYARLCQMTEEKVSPFQLDAARHGFHYPGGKIDDIALICAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWF4</accession>
    <name>A8PWF4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1085</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731817.1">
        <property type="nucleotide sequence ID" value="XM_001731765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWF4"/>
    <dbReference type="FunCoup" id="A8PWF4">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWF4"/>
    <dbReference type="MEROPS" id="S09.025"/>
    <dbReference type="GeneID" id="5856122"/>
    <dbReference type="KEGG" id="mgl:MGL_1085"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1085"/>
    <dbReference type="InParanoid" id="A8PWF4"/>
    <dbReference type="OMA" id="LMFRTYN"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="212" mass="23183" checksum="833862375788C6E0" modified="2008-01-15" version="1">MHGLGDTAQGWLDVARALGRNQALQHIRFVLPTAPVQPVTINMGMSMTSWFDLYSLTDLDQGEDESGMRKSAAAIWDLVAQETNGSAPGLNGHKVPMNRIVLAGFSQGGVMAQLMGLTAQERPAGIAALSTWLPLHQKMASMHSKHTFPFFQAQGTVDPLVDYKYARRSFDYVQSSLGFGKLAEGHEYRMPHSACPAEITDLGSWLERVVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWK7</accession>
    <name>A8PWK7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731866.1">
        <property type="nucleotide sequence ID" value="XM_001731814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWK7"/>
    <dbReference type="FunCoup" id="A8PWK7">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWK7"/>
    <dbReference type="GeneID" id="5856171"/>
    <dbReference type="KEGG" id="mgl:MGL_1134"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1134"/>
    <dbReference type="InParanoid" id="A8PWK7"/>
    <dbReference type="OMA" id="RSMIDHA"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="250" mass="27384" checksum="F4914814F52387FB" modified="2008-01-15" version="1">MFLTRSEYDRGVNTFSPEGRLFQVEYALEAIKLGSTTVGIVTKEGAVLGVEKRVQSSLLENSSIEKIMEIDSHLGAAMSGLTADARTMIDHARVTSQNHRFVYDEEIKVESIAQAVCDLALRFGENTEDDEALMSRPFGVALLIIGIDENGPQLFHADPSGTFVRYDAKAIGSGSEGAQGELQEKYSKDLSLRDASLLALRVLKQVMEEKLDENNVQLAQVTPATSKDGRPTGDFRILDKTQLKALVDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWP3</accession>
    <name>A8PWP3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cAMP-independent regulatory protein pac2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731902.1">
        <property type="nucleotide sequence ID" value="XM_001731850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWP3"/>
    <dbReference type="GeneID" id="5856207"/>
    <dbReference type="KEGG" id="mgl:MGL_1170"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1170"/>
    <dbReference type="InParanoid" id="A8PWP3"/>
    <dbReference type="OMA" id="HIVMDIR"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52046" checksum="2C4A757855919AE5" modified="2008-01-15" version="1">MQGLTKTEYVQEETDHQPCPSSATYDTHGVSHIGEVATWDSSPLYPSKNIIEFSSSGERRPTYVGYIKSPADAILLLAACDLPDNVRNPNLGPPPRRISRRLLDDERASLIRSGAVFVWDEREAGMRRWTDGRCWSASRVSGCFLTYRELEVRKKNSDTSKDGPRSNLYKSEGLVKQSFSIRTSSNRKLHVISYFNKDDIKSGSLQRVSTDPRITGTGIDSWNVQVDDQEYGEWINRESDFLPKHIMKSQRSREVSLPEAAVPLKRMSSDEESLATVDDRDNARTLVPLNWRAQPAAQFASDMRYARPQRMNIYSDEPLPKRFRYDIRPISPCPPQFATSRGWSPAYDLASVAYPSSSSFYESQRVVPIPSRTYFSIPSYAPNPERPLLPSLCSTARTSEAEKGTLEALASLRSNSTKVPPITALDRVDRSASGMYPASRVRGRPAPVSVTDRHTLQKLSVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWU8</accession>
    <name>A8PWU8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731956.1">
        <property type="nucleotide sequence ID" value="XM_001731904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWU8"/>
    <dbReference type="FunCoup" id="A8PWU8">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="GeneID" id="5856261"/>
    <dbReference type="KEGG" id="mgl:MGL_1224"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1224"/>
    <dbReference type="InParanoid" id="A8PWU8"/>
    <dbReference type="OMA" id="RYDQTES"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="5">
        <location>
            <begin position="64"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="461" mass="51953" checksum="1C776318D1FC0780" modified="2008-01-15" version="1">MDHDDIARKRAERARRKLDQSQNVSASTPDTARCEKPAVADREWMHINHDVPVEQDARRVRLVSWNMLAQSLVRRELFPGSDCLKLKTRLPGIVAEMTSHDNDLGCFQEVDSINEIVPSIRQAGFDFVYERGYEEKKHGLMIMWKTKASTRATFESPVWKKVVRLDDVDKWGDTVDGPSLSRCTRNILLIVALPFSSGPGGIIVATTHLFWHPRYGYERARQAAVIMRELSSLRAASQEDWSSWPIVLAGDLNDQPHSSTYTLLTGQAAQYRDQIRTDLMASRVVHTSVDESRGLRTVHYAATVTEAGDEDRVLGRHRAPKENELLLPDEIIAFAQFDAGPTRPGHFRSAYGSHYAQLGPHAEFFRDRGTAPERYDQTESPIPTDQRQLQSFEPKWTLFSPLFRLTLDYILLAPRAHVQGPDFPVVTALLSLSPESVLHPGVPRVSVCSSDHIMIGAELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXA8</accession>
    <name>A8PXA8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731201.1">
        <property type="nucleotide sequence ID" value="XM_001731149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXA8"/>
    <dbReference type="FunCoup" id="A8PXA8">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXA8"/>
    <dbReference type="GeneID" id="5855508"/>
    <dbReference type="KEGG" id="mgl:MGL_1384"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1384"/>
    <dbReference type="InParanoid" id="A8PXA8"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="561"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="712" mass="77379" checksum="21F5EDFE2D4E09FA" modified="2008-01-15" version="1">MKRSESTSKSQSNGGKSRMNRHDIANQALGYDDSVAPHLFPQAFSSHHGSDSRPFSMMSRRGSDVDTFRNMGSGSTSRAPSEFGHLPHSTAQDISSSASIRPTVTSTTHDSLVRPLLTIDTYKDSPAKSGQENDGPEIPRKARTLASPQDQLPGMFLSTTPTSPTAPTSPRMGNNESTGAYRDLSKGAVVETNHEGNPAEPTKHPKIVASPRQSRQFSISSLPLSSIEMPGLTAAAEFLPPDSQSVGKSQFSTPLLVPDGSGPLSWNNDMGDQVTGFAVASSKRNADFHALFPSLPEDDYLIETYSCAISRDLLIQGRMYVSEAHLCFHSNIFGWITSFTVAFADVVSIEKRNTAYLIPNAICIRTLQNRYLFSSLVSRDLTYSMLVSVWRMSSPSETAQEVAASMSDASEENDLSDDDDDDKKSAEAAAPGFTAETATPSNAAPSVTSPNPRDSTDAPRTSLTPEQTNEGIAIGKNESNSTPNAKGKSEGMTKREKLRRHLSKARKNIKKKDPMSANPATAVAGDDDNSDDSDSSMSEGADGSEDHPTTTCDCDSEQAHLANVVLDEVFDATPQQVFDLIFVNDFMEKFWSDNQKLFDIDIGEWSSDKVTIPDATAARAVSYTKPLNGPIGPKQTKCLITDEQLHMDFDKFCTAVTTTRTPDVPSGNNFAVRTRQCFTWAEYGRCRLYVTCDVEWTGRSMIKGVIDKASVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXG4</accession>
    <name>A8PXG4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731257.1">
        <property type="nucleotide sequence ID" value="XM_001731205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXG4"/>
    <dbReference type="STRING" id="425265.A8PXG4"/>
    <dbReference type="GeneID" id="5855564"/>
    <dbReference type="KEGG" id="mgl:MGL_1440"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1440"/>
    <dbReference type="InParanoid" id="A8PXG4"/>
    <dbReference type="OMA" id="IKNQFYR"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="224" mass="25804" checksum="ADAC17F70A242BE9" modified="2008-01-15" version="1">MPYRMYATTSTEADFYAILEVPRHASKAQIKNQFYRLSKQYHPDVSKTEEGKIQFQRVSEAYATLSNDAQRRAYDQKLGVGRSSTMYSSSRRSPHDPPPMSAASRFAHARSAWEYQQRTHQRTHSASPRYSAGARSRMNHNTMSETTHHYARMAEREAKRSEARQRYGPTPAHAHANPSSYRAWSEKRWNHEERQAEMASPVVRFLQVASVMGGAIWLSHKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXP8</accession>
    <name>A8PXP8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1497</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731314.1">
        <property type="nucleotide sequence ID" value="XM_001731262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXP8"/>
    <dbReference type="FunCoup" id="A8PXP8">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXP8"/>
    <dbReference type="GeneID" id="5855621"/>
    <dbReference type="KEGG" id="mgl:MGL_1497"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1497"/>
    <dbReference type="InParanoid" id="A8PXP8"/>
    <dbReference type="OMA" id="QWRGDIE"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="613" mass="67291" checksum="C076397DB2552DB2" modified="2008-01-15" version="1">MASNATANRVARWIQDNRVAVVALAATATVASAAGLYFLASSSTVPRAPTQPKSSSSSAAASGTSSTASKKKRAKKSSKKSTSKSAADGPILDDASDESLAELSESELQRLPQERKDSVAQYLKGLGNKAYSNKKHEEAIQHYTKALSIVPSAVFYSNRAACYANVGKPENVISDCNEALKLEPTYIKALNRRAVAAEQLGEKAEADNAEGEKARRRLEQSLSDFTAVAILGQFRDTSATTSVERVLKKLASSKAKLILSHREPRLPSPTFVKAYLDAFRPKDPPSIADGAPQGDKTLQRAYEALQAQDYAHALTLFEEAIKQGLSSKELEANAYNMRATFMFVIGLAKRALEDLDHSTDLCPDYLQSWVKKASVHVELGDKDAAFADFDRAMAINADDPDIYYHRGQVHFILGEFDAALSDYEKSTSLDDTFIFSQVQHAVASYKLGNIARSTAAFCRILKKFENSSESYNYFGELMLDQQRHEDAVANFNKSIELERKKSKGTNVLPMINKALVLFQWKHDLAGAEALCRDALEIDPDCDVAIATLAQLSLQQSKIPEAIEYFRRSADIARTEPELVNAITYEYASRAQLQFIRDYPEQGAALSQIASSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXV4</accession>
    <name>A8PXV4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731350.1">
        <property type="nucleotide sequence ID" value="XM_001731298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXV4"/>
    <dbReference type="STRING" id="425265.A8PXV4"/>
    <dbReference type="GeneID" id="5855657"/>
    <dbReference type="KEGG" id="mgl:MGL_1533"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1533"/>
    <dbReference type="InParanoid" id="A8PXV4"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="1">
        <location>
            <begin position="91"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="198" mass="21964" checksum="72066A31DA451BC9" modified="2008-01-15" version="1">MQLGRSAAFLASTRCSVRERRTASPYSVALRILLEQRRDADLCRQEARWLADEVRARHRLASTSAWNAQAMHELMEIARRAARNEPLSYVIGTGCIALTLAHGLRMHKDVHITAVDCDAAALELARENAKAHALDGDDDSDDALVSIRYADMLDDHSMALLGSFDLVVCNPPYIAADAWQDLDASVRDYESHGANIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXW1</accession>
    <name>A8PXW1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1537</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731354.1">
        <property type="nucleotide sequence ID" value="XM_001731302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXW1"/>
    <dbReference type="FunCoup" id="A8PXW1">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXW1"/>
    <dbReference type="GeneID" id="5855661"/>
    <dbReference type="KEGG" id="mgl:MGL_1537"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1537"/>
    <dbReference type="InParanoid" id="A8PXW1"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725386" description="Mannosyltransferase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="369" mass="42472" checksum="BCA40C9F19F121A1" modified="2008-01-15" version="1">MVLRLLVAVHLIAALATSRTFFQPDEYWQSLEIAHRIVFGYGYQTWEWMTSKPIRSVVYPAMFVPLYKAMQAMHIDNPFVFTSAPAIQQALITAVGDWFAFHLVTRIAGHRLALVWIIVHLTSLYWLYTASRTFSNTFEAAVCSIALYYWPLSRAAVNHLRVPKSSCAYRMALFAAWLAVLIRPTSLVLWSFLGMRLVNDALHCKCFWRVIREPLWIGSLVLGAGFYIDSMYYDSWSWTSLNFVRENLWNSVSSFYGMNSWHWYFSVGMPSIVTIHLPYVAIGWWHRRGVRDPASVLTLFQACVWTLLVCSCLHHKETRFLQPLVPWLHLAAAIGMEPLQSTTSVRAAWSAVPRWIRALLFVQVPIVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY22</accession>
    <name>A8PY22_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sphingomyelin phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731392.1">
        <property type="nucleotide sequence ID" value="XM_001731340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY22"/>
    <dbReference type="STRING" id="425265.A8PY22"/>
    <dbReference type="GeneID" id="5855699"/>
    <dbReference type="KEGG" id="mgl:MGL_1575"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1575"/>
    <dbReference type="InParanoid" id="A8PY22"/>
    <dbReference type="OMA" id="SEANCTT"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728007" description="Sphingomyelin phosphodiesterase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="349"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="136"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="139"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="286"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="708"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="742" mass="82912" checksum="169DEFCDE065D6A8" modified="2008-01-15" version="1">MVKVAVFVVAAFYAIGVCWPAQAASPSSSSTRNAVSTTKPGSTLIAVPTAFPTGEFPKMDFMPKSQEAEPRPHITRVDGGDFDDDLVNPTKLPTGAHFQVRVCWRSHRRLSSRLHRQTFSTMPSELTRSSRTTQRCERCRKALRVGQTLARANPSVVPDIMVELCKTFKYTTKPTVDIGCERKFATQHVGGVLTQVLSYADFSEDSSSADYMCAAYIQGKSCPFPEMKTLSSDFLNKWFNGTTKAPSSVVQRSKKVGDKREKPLRVFHGSDYHVDPRYLVGSEGNCDNGQCCRADSYNSTLWNKPEFDAGSIPTRNISHPADYWGYFKCDSPWSLIASAMQGLSALQRGSPLDLALYTGDLTTHDEDWHISRDLVKYSEQSLFDMFHHHMPNTTMVVALGNHDSAPSDNAVPNSLPDGRADQLSWDWDNVAKLIKSEGWGNDSTAQTIRSHYGGYSISPRKGLRVISINTDMWYHNNPFVYLNMNHPDPSHILRWLTDELQAAEDANERAWVVGHVLTGWDGGDAIDNPTNLLYHIMSRYSHTIAHAFFGHKHEDEFQIWYEMSNGNSSSVSRKTQDARAMAFIAPSVTPLSNVNPSLRVYEVDPETYEVMDYEQYYTQLYGVDKLNGTGPSWNLLYTARDAYANFSASQAKGTYAAPVQLDDGVWPKGAPLNASFWAALTDEMEARPELIEMHQLYQGRNSPRSPACDTEECQKAKLCYMRSASSNLGRHCPPGFGSVQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYG0</accession>
    <name>A8PYG0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ergosterol biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1655</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731472.1">
        <property type="nucleotide sequence ID" value="XM_001731420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYG0"/>
    <dbReference type="FunCoup" id="A8PYG0">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYG0"/>
    <dbReference type="GeneID" id="5855779"/>
    <dbReference type="KEGG" id="mgl:MGL_1655"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1655"/>
    <dbReference type="InParanoid" id="A8PYG0"/>
    <dbReference type="OMA" id="AYAAFHI"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP44258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12936" checksum="E4A2F3562B6B2AF4" modified="2008-01-15" version="1">MVGMVAAMNGIQNVFKPAFSRKVYASTEGIRQATPLAARLFGIWNLTSAMLRVYAAYHMSERGAYLMCLGTFVIACLHFVSEMLFFNTLAMVPGSISPIFVASGSIIAMILQYSYYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYG2</accession>
    <name>A8PYG2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731473.1">
        <property type="nucleotide sequence ID" value="XM_001731421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYG2"/>
    <dbReference type="FunCoup" id="A8PYG2">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYG2"/>
    <dbReference type="GeneID" id="5855780"/>
    <dbReference type="KEGG" id="mgl:MGL_1656"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1656"/>
    <dbReference type="InParanoid" id="A8PYG2"/>
    <dbReference type="OMA" id="PWANRAI"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="79"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="158"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="356" mass="40867" checksum="AFED502BF1D5917B" modified="2008-01-15" version="1">MLTISPLLLARQTIFRLPIVCTSRTFSAMPPTKLPESSPNFASEDGRYHRQTSDFLHHVAKGTKFEPEVGRYKLIVSLACPWAHRALIVRHLKRMHEVENLLPLTIVDTFLGREGWSVAHLNVDRPNVHGTGNNIPGHESKRFLREFYLEADPSYAKRPTVPVLWDNKLNTIVNNESSELIRCLNTAFDDFLPEEVRGVTYYPEDLRKDIDAFHEWVLPNINNGVYRSGFASSMDAYQEAVIPLFESLERVDKEIGNKKFVMGDRLTEADIRLFTTIVRFDPVYHGHFKCNIQQIRGGGLPNLHRWLREMYWTIPAFKETTCFESIKVHYYSSHVNINPTSIVPVGPIPPIMPLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYI6</accession>
    <name>A8PYI6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731486.1">
        <property type="nucleotide sequence ID" value="XM_001731434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYI6"/>
    <dbReference type="STRING" id="425265.A8PYI6"/>
    <dbReference type="GeneID" id="5855793"/>
    <dbReference type="KEGG" id="mgl:MGL_1669"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1669"/>
    <dbReference type="InParanoid" id="A8PYI6"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="414" mass="47615" checksum="6790C4FD14B4329E" modified="2008-01-15" version="1">MVETTALFQPPPPYKDEYDITYMHGIAPLTHCVPHTNPLDENAVSHLALTDQHRQHMRRLYDLMQLMLLRQNRQLAERCFSLLLRSQDWRPQELWKLGLQVACMGQERDTALRYLLRVSRTRTTLRPYTIVFLIRELILAGQYQRAHEELTSIIGAYPYRHQPQLHTYLGLLTLYLGNVDEAECSDSDSSSSIPHVPMRLAKQVPHYVQRSARLHFENAIKVAPRYMAKQTAICKHRLRQQNIRLNRLRQQAKQHHQRLCKKMRQYGWVFQDDASENPSVQGLSTQDIISQEEEVGTDNTASNVFASNTEMRTTLPMSDYFGLDSDQHFQSDESDEDDPSHLNAIREASEGPSLPQGIGDTRDATPPVMSSESETEHSSPTAAETHDSLNLALPVVQWSVHVARTYLSMVRMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2023-06-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYL0</accession>
    <name>A8PYL0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731499.1">
        <property type="nucleotide sequence ID" value="XM_001731447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYL0"/>
    <dbReference type="GeneID" id="5855806"/>
    <dbReference type="KEGG" id="mgl:MGL_1682"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1682"/>
    <dbReference type="InParanoid" id="A8PYL0"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727929" evidence="1">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="211" mass="22706" checksum="DE30D21F3E165227" modified="2008-01-15" version="1">MYFSCAALLIAATAAVSNAAPAGNTQDVAGVLNWKSSSSQSESTMSPSTHRTSAQFASAFLPPPEKRSSPSTDSNGWTIYTDASIFDDLTVRDAPATQKPSTDSNGWTMYTDASIFDDLTVRDAPATQKPSTDSNGWTMYTDASIFDDLTVRDAPATQKPSTDSNGWTIYTDASIFDDLTVRGTPATQKPSTDSNGWTMYTDASQFTYTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYP5</accession>
    <name>A8PYP5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731517.1">
        <property type="nucleotide sequence ID" value="XM_001731465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYP5"/>
    <dbReference type="FunCoup" id="A8PYP5">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYP5"/>
    <dbReference type="GeneID" id="5855824"/>
    <dbReference type="KEGG" id="mgl:MGL_1700"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1700"/>
    <dbReference type="InParanoid" id="A8PYP5"/>
    <dbReference type="OMA" id="CFSVQYH"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP44303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="427" mass="46979" checksum="03EBF88C13BE1101" modified="2008-01-15" version="1">MYRISPQRLCLRFVRGVTTWSAAPASQPATLKLKTGESFHGRSFGAQRSVFGETVFTTSITSYPESLTDPSYTGQLLAFTQPLMGNYGVPDNSVPGSAREHPADVDVGCFLESKGVQASGVIVSELCERFSHFQAYESLASWCARHNVPGIQGVDTRALTTVLRNQGSTLGAILVGDDHTRVPDQAEFIDPMAQNLIAQVSTKAPYTIHPRDGAASARAHVAMLDFGMKANIVRWLLRCGLSVTVLPWNADFYSMRDQFDGLFLSNGPGSPESIQSVIPGVRRTIDEWDRPIFGICMGHQIIGLALGLRAYRMKFGNRGHNQPVLALASGNMRVDPGRVYITSQNHGYALAYNETGPDAWPEDWQPWFVNANDWSIEGIVRTGGLDKHAPVWGVQFHPEHAGGPEDTNPLFDDYVEQVVRYKALRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZZ0</accession>
    <name>A8PZZ0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730964.1">
        <property type="nucleotide sequence ID" value="XM_001730912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZZ0"/>
    <dbReference type="STRING" id="425265.A8PZZ0"/>
    <dbReference type="GeneID" id="5855271"/>
    <dbReference type="KEGG" id="mgl:MGL_1963"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1963"/>
    <dbReference type="InParanoid" id="A8PZZ0"/>
    <dbReference type="OMA" id="CEVALAW"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="566" mass="63181" checksum="C28456B5AE26F27B" modified="2008-01-15" version="1">MRLPRRTPYYGNVQEEISYVYERFYGNRRDRNAIESALGVVRLWIHRTCCPQAVESTALLVESVMLDQTRVSDYAARASYAMALTRLVNSVVDSFQTGVYAQSIGAIAEQIGLPQWLVQVRHCSTHEELPSISVCRTASERALAWLDHHYWRPTLQVYNGGSLYSSGEQEGDDVESGMDDGEQEARATTRVRAAQLLYAYKQQATAVLRDKSLMQRSMPPHFHALVQIEQFVRQEWSRRAARPMLMSTAARLGRRAHDKDGESDEPGDPSFSLEDEEETKQLASVLQELISQLLLPGALFPTDMKQRRGRRGRTDVAGMDSPVSEEAARLWDPLFRHMHVMAPMFLPLLVDALVCAAMSERTCARAWLQHLANMDEIEVPLHVPRWPHENSGSHGMTSTLRTSTDRMRRGPLRRTVIFYALETPDHDLHTLALSLCDNDANLHSRVEQLCRLHQLSHVDESVAASACLGEMEERAATLPFWSAENDAAYSPIGDAMEDEAMSEPHHARLTDQGGTGFSDGYADGDATASPVAADSAPPGWRRAPASYTATPIGCLAGQRPALLLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q096</accession>
    <name>A8Q096_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731002.1">
        <property type="nucleotide sequence ID" value="XM_001730950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q096"/>
    <dbReference type="STRING" id="425265.A8Q096"/>
    <dbReference type="GeneID" id="5855309"/>
    <dbReference type="KEGG" id="mgl:MGL_2001"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2001"/>
    <dbReference type="InParanoid" id="A8Q096"/>
    <dbReference type="OMA" id="NKYTQIA"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000004">
        <property type="entry name" value="Related to atp synthase epsilon chain, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="64" mass="7569" checksum="E37F8FD7504AA477" modified="2008-01-15" version="1">MTQATWRQFFSYSKYTQVAARAVRQSLKETERVEAERRAFQALRYQEWKNGEASENISLAPPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0C8</accession>
    <name>A8Q0C8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731015.1">
        <property type="nucleotide sequence ID" value="XM_001730963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0C8"/>
    <dbReference type="STRING" id="425265.A8Q0C8"/>
    <dbReference type="GeneID" id="5855322"/>
    <dbReference type="KEGG" id="mgl:MGL_2014"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2014"/>
    <dbReference type="InParanoid" id="A8Q0C8"/>
    <dbReference type="OMA" id="DEIAMED"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="888"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="631"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1202" mass="132287" checksum="1224194899B969A2" modified="2008-01-15" version="1">MSMLHPSSLHGRVGSCPIPIRRVHSFDASQREHGSSPSSERSCSLSPPSSPLHFSKRHMVPTSRNHTRVSSVPNLRTVRRLSNHFQGSRPHVRSYSPPPAVLSAPHLNLPVPAGWQEGPFSASSNARISSPLSESFEGGEAFTQREPPPVPGPDVIDSVWFDSPPAETVRTPDYSDEMERFGPVFPTSPVLALDSAGSASDKVVNLGFPRLSSLSLQSSTSPPDMTVSPRSVPDSPPKTRSNIALPPRSGYSLSDDSDSLRSEGDTSAGSGPSSNESSSENEGDSALDDDDDDDDDSNEQRIRKWQLVRSSAVPTLPDATVQRAGLVPDSTMYADVSTNGTRHRTSDSEEEEDTSNDADAEDEREERSVRKTAALLAPLSGVTAPEVSTAGNAPISATAPAVEEDLIDTTVDPDETTEFLDDGLSCLERIFLFAKSDLAYHRVLVSRCLADWIKDVDLTDAVEYIIPLLNGLATDELEVSAVFAPELGRLMWFFFRNCPLQELSDLEPSTDDTDEEIMPRPCITVSTFTPLLCSLLLNPNNAVSGATQASIVEYFLRSKHYDEALRQEDDDSHSTADDVRHADLVEMGMARDKLVPLTPYNFGREAREAVLNELFEHVAIAISCMDDSTPEPSASTAAASSAIPAPNTDKAESGAGATPYERLPFDEESALGRMMSVNLLAAITVEGGFSREQLTCRVVPEITSWPCDPAFFVRKEVAAAIGIIGKALMVEEDDGFLLEETNAPVRLFEAINRVLLDHVWQVRQAACYSLPGVFAIQPHNQARRENLVLIMRALKQDVSPNVQLAAFEMIGEVIYLFHDDDAGVPDELVRMFMGLPIDAALAVDTGNGTTSDTEAHRDLLSNSDYSLIIAFNFPAVLLTMGAQHWPKLRPLYMQLTQHAYDNVRNSLAASLHEIARLLGSEMAATDLVPVVDRFLHDSCLDVTATLLEHMDEFWLLLPPHIAREQLRRIPALWFDAYSQEWHLRQSLAMHIPSLVPTLLLTDEDGCLVTLLLLALNDSVNAIRAIGCHAVPIIYHTFRLHDETIADGFLSMLCDFAYAPTSRQRSTFLHIARVLLEEELGCDRFEHLVLPCLLKLAGDCVMDVRIALVRTFQQIWSRHWYTSQNMPHSLLRVAATLLACRVRVVQDIMRSLEPPLQDVKVSEAVPPDERLPLEFGPARPLLDQTTIPWRNIDECEQSDGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0D1</accession>
    <name>A8Q0D1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731016.1">
        <property type="nucleotide sequence ID" value="XM_001730964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0D1"/>
    <dbReference type="FunCoup" id="A8Q0D1">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="GeneID" id="5855323"/>
    <dbReference type="KEGG" id="mgl:MGL_2015"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2015"/>
    <dbReference type="InParanoid" id="A8Q0D1"/>
    <dbReference type="OMA" id="DWTQITW"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="810"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="912"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="142"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1021" mass="116508" checksum="564787A4A067BA1B" modified="2008-01-15" version="1">MHRPFDERIMGPSVESESDDDDVFAFTDTGPRREFLTTPQIEAHREEAADVPQDDVDEWDDALRTDARGSERAPLMIDETHETSSMRDSNLMGCLHPEHVHAYHQNEWSVNELPASESSLNEFPLDELSPIQTRPGCFSFNNEPSLAWRPPKSSSSEFPYSRARTPNQMPPRSMQVPEWSQYPSSASRLVSRDLKPDEDPRDLLSESPVAMLPDQAYKRSRSLTSMSDMPSSVHTNERSLFRYRNRRDAYARSTKTSSRVVGADEDKESWENEHELNSLNESDEAVDHDEESFIAGDGIEEDSPYPEVRASVSNIDDPSMPTATFRVIFLSLFLSTLAGAANTYFMLRYPAPTVSPIVITVVSYPLGKLMAAVLPTRTVQLPSFLGGSEFSLNPGAFNIKEHTLISSLASISIMPSYIVNFLVSRQIHFTHRVNHQYWFDYLYMIFTRVIGFSFSGLLYRFLVEPASMLWPQVLVVTTILNTLHAEDDRQDKRISRMRWFVYVVFGAFFYNFLPGLFFEFLTVFCWLCWIRPTDRVLNIVAGANGMGLTSFTFDWGQISFFGSPMVTPWWAECNFFAGFVLFAWIVMPILYFTNTWGSGYFPFTGHMAYDKFGKPYQEEKVIQQSNFQFQHQKYLEYSPLYLSIGFVVSYFGGFASITAVILNMILNHYDDILRALQRKTPETPDIHAKLMRRYKHVPTSWYFTTLCICFIALLLIVDFVSFKVPMKAIIVGMVLPLFYTLPSGFVVAMSGQMIGDNILADVIGAYLTPNLPEGFSLFKSLAVQTLTGCLQFTGNMKLGHYMKIPPRTMFLLQIVCATITGCVQMAVKDALVMNVPDICTENSKFQLSCWSPNLYFVTSLLWSSIGPRYIFKGEAFQFILWGLLAGTAAPIITALIKWKWKLNWINYVSWPIFFFGVGMLPLSHSINFTAWFSVAFFFQFYLRKYYFSWWSKYNFVTANALDIGTILSELLIFVAITLPTANQNILQWWPNTVVKRNADAHAMPLYNIPPGGIPSAEHLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0D3</accession>
    <name>A8Q0D3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731017.1">
        <property type="nucleotide sequence ID" value="XM_001730965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0D3"/>
    <dbReference type="FunCoup" id="A8Q0D3">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0D3"/>
    <dbReference type="GeneID" id="5855324"/>
    <dbReference type="KEGG" id="mgl:MGL_2016"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2016"/>
    <dbReference type="InParanoid" id="A8Q0D3"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="248" mass="27576" checksum="A3093C4C23AE7662" modified="2008-01-15" version="1">MAFYHLRKMQAEQSLCIAPDIEVIPYPISHGPTRLAAGVSQFDEQILQAPRVEDCHCHMNGDFSRTVSTAFHFKNRRLDRDVLFLGDVEPDQIAGSNNNLTLWEAVAKRAAEGKLKAVFIECSFASEQPSHLLFGHLTPIYLYKELEALARCVCAARKQDESSLENSLRGLKCIVIHVKGMVLSADPSYSCCNPIPKTTSATSLPLPIPILQLIEKELHALESKGRLGVEFVMANRGQRIGTWMSTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2023-06-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0D8</accession>
    <name>A8Q0D8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731019.1">
        <property type="nucleotide sequence ID" value="XM_001730967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0D8"/>
    <dbReference type="GeneID" id="5855326"/>
    <dbReference type="KEGG" id="mgl:MGL_2018"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2018"/>
    <dbReference type="InParanoid" id="A8Q0D8"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="85" mass="8938" checksum="68C48014AB9E6D7B" modified="2008-01-15" version="1">MSSSLADELAADLLEDQTQGGNIEKDESVSSMFHISDASMRDASGAHAHGASQPPDELNQAQLDAWDVGQSSISDVSSISKLYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0G7</accession>
    <name>A8Q0G7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731031.1">
        <property type="nucleotide sequence ID" value="XM_001730979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0G7"/>
    <dbReference type="GeneID" id="5855338"/>
    <dbReference type="KEGG" id="mgl:MGL_2030"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2030"/>
    <dbReference type="InParanoid" id="A8Q0G7"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050326">
        <property type="entry name" value="NAD_dep_DNA_ligaseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810:SF1">
        <property type="entry name" value="DNA LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="5">
        <location>
            <begin position="58"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="320" mass="36440" checksum="90B4D99D0AE775DA" modified="2008-01-15" version="1">MGLSTQSLRRFLSSKEPTHYSPAALFLSELYETGCITRMNMPVALARSWDAATCPPTSSAWYASRKLDGVRCVAVIGCAPPSRIQSVHLLSRTGRNFGSLRTLQDAFAKVLEACPHMAQIRLEPESKPMTWVLDGELCVIDETQSPFRESFVRAMSQLQQHPSSTDECVATDLVYFPFDMLTLDEFTMGAKEIRRYSARLAHLQRVVSWVHARHPRAPIRALPQVRIDAQDTLDRMLRDAAHWEGIMLREDMPYEGRRTHSMRKIRPKHEGEYLVRNIEIRTMRLALDGTYADRHALASMYMQKQGKGAPCCDETRARLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0H8</accession>
    <name>A8Q0H8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731036.1">
        <property type="nucleotide sequence ID" value="XM_001730984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0H8"/>
    <dbReference type="STRING" id="425265.A8Q0H8"/>
    <dbReference type="GeneID" id="5855343"/>
    <dbReference type="KEGG" id="mgl:MGL_2035"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2035"/>
    <dbReference type="InParanoid" id="A8Q0H8"/>
    <dbReference type="OMA" id="WFTVTNL"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="117"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="380" mass="42212" checksum="B2DCC32A29CBDDD0" modified="2008-01-15" version="1">MSPTPCVWKHAARASTSLTRLPSQHPTITWRASSSSSAGDKRRPRDSLLRRNLAPLSPPTPPPSKTKYSPLTVALVKGTGRLLGYNFVRSKAIKVTGDLYDRAAMRAQAEAHFWYKECALPASFQTWFQLTNLHVFLLLSRIRALPSQEAKTYSQELINHFFIDTESRMRERFGVQTSRLVKGYMKDLHLQHRGSTVAYEEGLATDDIRLSAAIWRNVWGGGWGVIGGVKRKAPSLSTKKSQHNTLQASGRQPSNETDKDGKVVADNQAHSDHEDAVPDYTVDQDALMAQDKTDGQREARAELLFPQHLERVTRWLRREVYRLGHLPDETVMDGDVHAPRAVVEDVVGPPSASTTAAMSATSSSQSEGGVQTIVSAYTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q122</accession>
    <name>A8Q122_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731116.1">
        <property type="nucleotide sequence ID" value="XM_001731064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q122"/>
    <dbReference type="FunCoup" id="A8Q122">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q122"/>
    <dbReference type="GeneID" id="5855423"/>
    <dbReference type="KEGG" id="mgl:MGL_2115"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2115"/>
    <dbReference type="InParanoid" id="A8Q122"/>
    <dbReference type="OMA" id="VCLKALW"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="218"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="447" mass="50003" checksum="904F963E88E0D7CE" modified="2008-01-15" version="1">MLGLTMRADLVAVLSDTTLREHADECCILISRVFPEEKRAEWSDALTKEASLADESSDDSTAKAKAREVVAKLTQSIPGLIECTDRELEGLYNLVMALLIKYYETEEESFCNLVMHLVNVVSDTQSSAAMERSIIKYRILSNIFNLLPTASPLRLRVFKALLTLVSMNGDMDFLDMALQSVPIWLAQWNISSEEKHECLCHVADALQLPDCGPAYMDRAYEFELIHLRFISGEQSLSNEVRFSAAENAIANILRLPKLFEMEEVLRVADTLNLGTSPMLSLLRLIVSGTRADFEQWAQSSDGKGALERLSLDASELTHKMRLLDLASLCARSVSSEVSYQDMAQTLGVSVDEVEAWVIDVIRAGLVSGKLSQVKRSFRVYRSTYRTFEKSQWESLEQRLSQWQHSIQTLLRTMQNARTQAPQALMSEHQTTSVATSSAESNDAPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q135</accession>
    <name>A8Q135_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731121.1">
        <property type="nucleotide sequence ID" value="XM_001731069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q135"/>
    <dbReference type="GeneID" id="5855428"/>
    <dbReference type="KEGG" id="mgl:MGL_2120"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2120"/>
    <dbReference type="InParanoid" id="A8Q135"/>
    <dbReference type="OMA" id="VWERFSH"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36800" checksum="5DBA691535358AE2" modified="2008-01-15" version="1">MHFLDPKRRPCVLTEGRMVDVDDDKRTSCNRNEFHPSFGYPGSRFVFYPKCLNLMKGNTESPPAIPIMVPDTNIYMLFAHRQWRAGMLLADAIYTKCVDLSDKCVLELGAGTGLPSLTAALSSAPLKVVVTDYDDDAIVGALRSNVKFTRDANPNRRMAPIVAAGHSWGHAMDDVLDLLPPNHTHFDVILLADCVWERFSHDILLRSIKNLLSKSQDARIYMVAGLHTGRRVLIQFFRLAIAAGFVLVPLPNQDMWPSCTNEKQSTSLEGSEHVLELEVGGTWDENQSPSLTGGRRPFLLHRGNEGEDDEPIYERNHWLTVSCLAWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2023-06-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q152</accession>
    <name>A8Q152_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730737.1">
        <property type="nucleotide sequence ID" value="XM_001730685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q152"/>
    <dbReference type="GeneID" id="5855044"/>
    <dbReference type="KEGG" id="mgl:MGL_1736"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1736"/>
    <dbReference type="InParanoid" id="A8Q152"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727947" evidence="1">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="181" mass="20189" checksum="5B64DFCFD9BE00DD" modified="2008-01-15" version="1">MKVAILISMMAVAVAVATPVSLDDFNDKCKPVYRGTLVLHGNHQTHGTQVLRSDRYEPFVVKQDKVNHHTKFRFLECEQAKKGEKSYGVLMEESTGDCIYTSTINGTEDEPALIMGKVCAPEDEFAVTREGNEAKVSFVGDGHIEYGGWTSKRAHGYKFDTIRVTKDKDTWVGLEDVEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q176</accession>
    <name>A8Q176_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transport and Golgi organization protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730747.1">
        <property type="nucleotide sequence ID" value="XM_001730695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q176"/>
    <dbReference type="GeneID" id="5855054"/>
    <dbReference type="KEGG" id="mgl:MGL_1746"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1746"/>
    <dbReference type="InParanoid" id="A8Q176"/>
    <dbReference type="OMA" id="QAGGSWF"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36389" checksum="3F0E437BA325A032" modified="2008-01-15" version="1">MCIVFWTVNDPEYSLVLLGNRDEFLLRPASRAAWRSRTREHVLETDLVHGNILCGVDLLAGGTWMGITRSGSFAALTNVYEMPAPQLTQDGRPLRSRGELVMKWLDAQHSEPGLSASAIDEMYLSRGDYGSFNLLVGDLSEEGAHVRYISNRTSDHEYNNAIRSNENQRVCGLSNSPLQKPWPKVELGEKLFQSVLSEERSSQACLIERLFNVLQTSSYTRHVPVPEAMRHTIHVSPMKMPSKADQMHLSSTPNPDTFAWYGTRTSTVILVSRTSPRRATFVERDMYSLRDGTLEPISLNYHDESVRSQHERKYEWELTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1M9</accession>
    <name>A8Q1M9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730813.1">
        <property type="nucleotide sequence ID" value="XM_001730761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1M9"/>
    <dbReference type="FunCoup" id="A8Q1M9">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1M9"/>
    <dbReference type="MEROPS" id="C12.002"/>
    <dbReference type="GeneID" id="5855120"/>
    <dbReference type="KEGG" id="mgl:MGL_1812"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1812"/>
    <dbReference type="InParanoid" id="A8Q1M9"/>
    <dbReference type="OMA" id="IDLHYVC"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="9"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="234" mass="25398" checksum="E84C79A3D18D0655" modified="2008-01-15" version="1">MTTASAPTSWVPLEANPDLFSTWCETLGLDTSKYAFYDVFGLDDELLAMVPQPVEAVLFLFPLTSRIEAHRSGLQKKADEKSELLWFPQTIGNACGTIGLLHAIANSAAAQAIRPESVLAHLLARARSVPPAERANLLLQCEDLRSAHASTAAQGQTAAPTAEDDVDLHFVAFVRSSTGALVELDGRQDGPVERVPYIERNELLSRTAHVIQQDYMAVDPDQVQFSVVALSQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1Q2</accession>
    <name>A8Q1Q2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730823.1">
        <property type="nucleotide sequence ID" value="XM_001730771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1Q2"/>
    <dbReference type="STRING" id="425265.A8Q1Q2"/>
    <dbReference type="GeneID" id="5855130"/>
    <dbReference type="KEGG" id="mgl:MGL_1822"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1822"/>
    <dbReference type="InParanoid" id="A8Q1Q2"/>
    <dbReference type="OMA" id="GMITRNN"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1092" mass="118633" checksum="1A7A9D93F02C6C1B" modified="2008-01-15" version="1">MSSSTFHVDSTSVVLIGLLAVLLLYAKFHRQYNQPLLHPLILQRQSDASTVRMPKESPSYRNVNAPLGLDLAMRPHRNAPTIATMLARGVEEGTSALTRRVLDASLSNEEIRTQAALFLSGVQVMLQTDRPTIVVCGFINSSRSLTALLASALVGSQSNYGGGTQTYVVPPGEPPSSMPSDVNLSKTAVVCLDAPLLPMLTRAGLVIANENSDLHGTKCVGWDDVLGQATVDQAPPVLDTTRLSNAELDRLGTSVFASFWDARNAWVQVTETSMTSGVTAWLSQFPVDAIPQKGDVMLTDLMYARAVPAPVYVTLLLAGLYTGAGLAMEPSVDLVSTIKTLHPTLLYVGTSGAQYLEQSVWMPSVGSLLWPLMRRMNMDLIRNGIFPKDKLLDKLVCKRVRDTLGMDQVRATIVAGDGSAAEQSLVDSLRLYLGVPVMHSYVPQRMECHHQPSLVTAPVCTSNLYDLQAFAPQLVHDDSARCLPAHVGPPSVSLEIKLVDDTPAVRAHSSVIQRLREDGNHDDPIGEVYVRGYTVSQTGHDDTTISPWHATGDVALVRTNGTFVVIAPHGAKEAGVMPNTMTSTEASNLLAQRFRDNASSGMPPRRTSGARIASSAPAMLAMLLFLVGCVDARHMMIMAPLHHEPRMHMLSRRAKDDTDPKTNTTMVNLAFQGIMAMQRASWEHGVLQSAMIEYSYPQWSMFKRSDHGDLFPPAKSVPSDQVPNDLIKLAQSSVDGQDRQGRLATVITGDEDMGQGASMDSASCGEGVLLAAWVYEGFPNQAPDPHGYYGPAAAKQLRYLLKNVSRTPTGAISQRASPKQVQLWSDSAYMGPPFLAYYGWVTQNQSLVQMAFDELKLQRSALHRPQDPGRHLWRHIIEFPNHTKATRAIDARVWLTGNGWAAAGMLRVAAIISHSPWADKMQAQHDQLVQWADDIITAAYQFVDPGTGLLLNAIDDPSTFLDGSGSALLSYAVFRLASMDQGRKKHVDMAEKAYQTLSKSLNSLSQFTNGIQTVNEMQSNEAGATSTESLAFLILMAAARRDYHANNVTGSTGPLNVSDKSSSAWPSHDLPSISWFSAAILTLIGLVNALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q257</accession>
    <name>A8Q257_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730688.1">
        <property type="nucleotide sequence ID" value="XM_001730636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q257"/>
    <dbReference type="GeneID" id="5854984"/>
    <dbReference type="KEGG" id="mgl:MGL_2142"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2142"/>
    <dbReference type="InParanoid" id="A8Q257"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="268" mass="28717" checksum="BD19A1679B820794" modified="2008-01-15" version="1">MRSLSSLGPVGCYLRNMACLIARHQHAQQSLHTSCKRFHYDELFSWDDETRIPSARNVTCTASGLLRLGHGGLSVCQGADSSHMLSLAQAAGMLAAKRASDVVPTRMSRTLRDVQVWIYAEQPTDHEATDRDKSSPSLMTEEHTPASNMSSSMSPKGDGGFSAEGLLDPDTWMAQAPQPAASASAPGAVSDTHVPSSIEMGSRMQSGSAWMDANTTVRVVCRTRASEPTHTEAMAACMATCLTLCDIVHASCGHMPVVEQMSVSSEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q280</accession>
    <name>A8Q280_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730709.1">
        <property type="nucleotide sequence ID" value="XM_001730657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q280"/>
    <dbReference type="FunCoup" id="A8Q280">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q280"/>
    <dbReference type="GeneID" id="5855015"/>
    <dbReference type="KEGG" id="mgl:MGL_2163"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2163"/>
    <dbReference type="InParanoid" id="A8Q280"/>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000085">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="563" mass="61244" checksum="FA0C49BC288BE6F7" modified="2008-01-15" version="1">MSAQQPVFVVNTGPERHSGRKAQASNIGAAKTVADVIRTCLGPKAMLKMILDPMGGILLTNDGHAILREIEVAHPAAKSMIELSRAQDEEVGDGTTSVIILAGEVLAYSMPLLERNLHPVVIISAYKKALTRALQVIESISIPVNIEKDDEMLAIIRTSIGTKFVSRWSELMCRLALKAVRTVASIDPTVQRSVDSLSSGVTVDLKRYARVEKVPGGEIENSCVLDGVMLNKDVTHPKMRRRIESPRIILLDCSLEYKKGESQTNIEITREEDWSKILEIEEQQVKQMCDKILEFKPDLVFTEKGVSDLAQHFLLKANVTCIRRVRKSDNNRIARATGAQIVNRVDDLRDTDVGTRCGLFHVEKLGDEYFTFLEKCQDPKACTILLRGPSKDILNEIDRNLADAMSVARNIVFHPLLAPGGGATEMAISVGLAQYAGQSLEGVEVAAVHAVADAMEVIPRTLIQNCGGNTIKTLTQLRARHANGEYSYGVDGNTGRVADMKQYGLYESASVKIQILKTAIESASLLLRVDDVVSAKRGAQSGASGPTAPNMAMAGGEEGMGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2N0</accession>
    <name>A8Q2N0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730416.1">
        <property type="nucleotide sequence ID" value="XM_001730364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2N0"/>
    <dbReference type="STRING" id="425265.A8Q2N0"/>
    <dbReference type="GeneID" id="5854723"/>
    <dbReference type="KEGG" id="mgl:MGL_2212"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2212"/>
    <dbReference type="InParanoid" id="A8Q2N0"/>
    <dbReference type="OMA" id="GAWVNNP"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="71"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="303" mass="34024" checksum="F72FAD64656A5E2D" modified="2008-01-15" version="1">MPLMGDFDAVRKDIASILKRKGYDDGSIGPVLVRLAWHASGTYSKEDETGGSNGAGMRYEEEGGDPANAGLENARAFLEPIKEKHPWITYADLWTLAGVVALKEMGGPDVEWKPGRTDFVNTKYLPPRGRLPDGAQGQDHLRNIFYRMGFNDQEIVALSGAHNLGRCHRNRSGFDGPWVVNPTRFANTYFKMLLNLKWEPRKWDGPFQYAAYAPGMDEDDEPLMMLPTDYSLIQDDKFRPWVEKYAADKDLFFADFAKVFAKLIELGVYRDEDGIARCDKRDAKGSYIAAPKKSNSTGAKPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2P9</accession>
    <name>A8Q2P9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730422.1">
        <property type="nucleotide sequence ID" value="XM_001730370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2P9"/>
    <dbReference type="STRING" id="425265.A8Q2P9"/>
    <dbReference type="GeneID" id="5854729"/>
    <dbReference type="KEGG" id="mgl:MGL_2218"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2218"/>
    <dbReference type="InParanoid" id="A8Q2P9"/>
    <dbReference type="OMA" id="EMHGAEW"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="198" mass="22264" checksum="CCF61F336BCD97FD" modified="2008-01-15" version="1">MRYQDVPVTAEGISTSEFIDATEGVVKLFDLLGSSAFAVVQNDMNGNIKLVLTRAQKIRDRLLSTGPDLSGTLQLLVKNEGLPGDKKRTATEGLLWLLRGLEFTARALRLSLENPSEELSTSFTKAYENTLRKYHSILVRPVFSLAMKACPYRKDFYAKLGPSEDVVRTPLTEWLVALEKIVQNMHQFYEQGQYAKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q330</accession>
    <name>A8Q330_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_2299</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730503.1">
        <property type="nucleotide sequence ID" value="XM_001730451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q330"/>
    <dbReference type="FunCoup" id="A8Q330">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q330"/>
    <dbReference type="GeneID" id="5854810"/>
    <dbReference type="KEGG" id="mgl:MGL_2299"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2299"/>
    <dbReference type="InParanoid" id="A8Q330"/>
    <dbReference type="OMA" id="KNVTPRL"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="349"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="431"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="505"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="834"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP43289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="882" mass="99941" checksum="D10D2ED23D8FBD7A" modified="2008-01-15" version="1">MDLGRSSSSMRARPTSHSQDMGMKSRKEKSRTSDSMPEKERESLGSLRETGDVATPVSPPPVVTRTEFFVLGILTLIALVVRFYHIERPSSVVFDEVHFGGFASKYLSRKFFMDVHPPLAKLLITFASWLHGFKGNFDFSEIGNEYLMGADQEPVPYIAMRSVSALFGTLTVPLAYLTLRALALRPASALLGSLLVIFDNALTTQSRLILLDAPLVFFVAASLCAWTVFCQLDAHRPFSRPWWLMLTLTGLALGLGLSCKWVGLFTVASVGVAVIVQLWYHLGNLRMPIQTLARHFMARALCLIVVPIVVYMSMFAVHFRVLSKSGEDDGFMSWRFRQTLKGNQVPDTYADVALGSTVTIKHLNTLGGSLHSHHHSYQSGSFQQQITLYPFMDENNEWIIIKAPGQDDYVKKADGHSITPDDEYTRFYQNVTYLKDDDMVRLLHKQTMVRLHSHGNHRPPISSGDYQNEVSGYGFPEERFGGDFNDNWIVEIYKQPPGLRFADKKRPITLRTIFRLRHANLGCYLYSHKVSLPDWAFDQQEVTCNSSPPLQNSLWYFETSEHPKFNAKTPRINYKNPSFLEKFIELHKVMWDINSHLTEPHVYESRPSTWPWLRRGINFWTKNHRQVYLMGNPGIWWSVLGSVLLYAGVRVLLILRAQRGYNDFTHTTVVKYDRICGFLAVAYVAHYAPFFLMKRQLFIHHYLPALYIGILLTASIFDFGTTRVRPMFRLYAALALAIGAGVLFARYSPITYASRWTNMACGDAIWLDSWDFNCVEFPQDIHEYATYDPVVNRPDGRGAQDEDAAWPFKLDRVLPQRLFPAHVTKQAKATHGAAAVTSSASVPAEETSSANSAGNDLPNVSGLDQAQRQQAVLIGHRRAPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3H1</accession>
    <name>A8Q3H1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730603.1">
        <property type="nucleotide sequence ID" value="XM_001730551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3H1"/>
    <dbReference type="GeneID" id="5854910"/>
    <dbReference type="KEGG" id="mgl:MGL_2399"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2399"/>
    <dbReference type="InParanoid" id="A8Q3H1"/>
    <dbReference type="OMA" id="CVVHVMT"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="454" mass="49569" checksum="30C743CD0FA2F430" modified="2008-01-15" version="1">MMLLPRALTGAWRISFSAAAKTLSFHTTAVPTFPRARRSIGPSRTAVVSHGRTDTHTSQASSSPRIPAAVPWFMEEEVIDAPVPPPAPSADVLPPIAWLPSYIPATSDIPEQLAQLIDMCVTGPLSALVARPAEPDDIDIDDWSERVRGSPLAVIKPMNPADTVGDEGQDWIVVVQVRGAGVGTVRRVASDIGTYLKHTRPPAPVPAEAIALDAILGPAQIVHEQDGLVSDGPAESASASGRGARPSGMSRAEHEAGQHLPAWEIQKLALMRKFPDGWMPMTKLSHEAQHGLRLLHAADPERFHIGVLSRRFRISPESVRRILRSKWQPSEEAAQRQNRRAKVQWRQQPAHASKDEADEIAGLRQGGVPVNTEPRQTSPEMSVVDPSYEHPVRMEGLVSSADLAGGRRRQKSVASRGSGDWCLIDAGWCVVHVMTAKAREHYRLEDMWRYNGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3V5</accession>
    <name>A8Q3V5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730090.1">
        <property type="nucleotide sequence ID" value="XM_001730038.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3V5"/>
    <dbReference type="GeneID" id="5854404"/>
    <dbReference type="KEGG" id="mgl:MGL_2472"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2472"/>
    <dbReference type="InParanoid" id="A8Q3V5"/>
    <dbReference type="OMA" id="AHRYCEA"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="10">
        <location>
            <begin position="274"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="9">
        <location>
            <begin position="470"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1160"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1187"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1208"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1282"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1329" mass="142225" checksum="AE8EBF9107FFEDBD" modified="2008-01-15" version="1">MQAKPAPSQAPPTRKTGSPPPKADVRSQTPASRAGLQGPPKATIRSSHRQRRSAANAQEAGLFPSSELQPLKATATGPASSQPNSATSITSHAASEKVPPSTQRGLNAQRNAELTSMPEAKSGPAPSKPSSVRSPSRPGAVNPAHAKTHEKPADRARIAARELPAAAPVAPSASSEQDAKTHAKIPSVSDVDNAWGWGDSAEFEQETEADTNAAAAVGAEDDDAWGWNDDQDADVQDDVYAHDAYASQEYVPAPPSTAGVMENDPMQDRGKASVPLAAFGIGGKLAIYLPLAVAKGDAFDYSSPHMQRSVKIHSLAHLVGARPFSTLDMHKFPGPLFEGTRVNHKQKKADTIRYLHEQISESASGIGYLRRKSVIHSTDDSMPQSDVNDWRRTEDKVLLLKLLVLLLEHDGKLADDPAQIPTVTDLLQGRSEATDFGAFNVPTYSRASSQSATKRPIRTYTLRQGFLEELQTILQEGDLPRAVDLALRERMWAHAMVLSQQLNKETRDRVMSEFVHHELDDSDADDALRKDYTSIKVAYGLYTDQTPEQIAELFRGPSQLSPEAQHVQWRQAVATLLSNRGSPNSQTTVLCAIGDGLMTAGLPEAAHVCYLLAHQHRAWIKMPEKPFLMLGTVSGAPVHTVLNDMDALLMTEVLEYAYSLSHPRNAEPYVGIPALAPYKIVMAAVYDELGDSARAKKYCDALINLTQTKGAPPLLTPMLQTELHQLMNRLNGTHVHGETQSWSKKLQRPTLDGVWGALEGRLTKFIAGEESAAQDQSKSKSQESAVGAFTHYSAITPEVASIASETPRPSVLGDTPTGGSYSADAYGESYVPQELSEPVTSEYAEEPYRGNYAEGDYAGGEYAEGDDQADYAEGDYAGGEYAEGDYQADYAEGNYAGGEYAEGDYAGDYAKEDYQGEYAEGDYTGGEYAEGNYQGDYAEGDYAEGGYQGDYAEGDYAGGEYTEGDYHGNYAEGDYAGGEYVEGDCHGDYAEGVVQGEYTEGNYPEAAYDENQVEESDSMEPSGDPDADKGETGADPCEDQDTTFTAQDNASPDVPDQEPQAEADNDADAKAETSPQADRNENDQEITPAAPPVFHRVESAVGQDGLLSTMPMPALEPIVPSATASKAPPPPSATASAAQDKEPDEDDDLGFGNTSHKKTTASDKNHAESQAKEPPKEPEPKAKPAEKSSGNSWLGRLLGSRSSSAQQNEKEGKAVRAHLGEETSFYYDKELKRWVNKKAGADSAAAPAALPPPPKKPANAPASDTKISSGNDATTKHTEGGPPSSTTSTTSRSAAPDTAAAKVGPPAKTTSSGGGSKRRTGKPRYIVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q428</accession>
    <name>A8Q428_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sin3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730109.1">
        <property type="nucleotide sequence ID" value="XM_001730057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q428"/>
    <dbReference type="FunCoup" id="A8Q428">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q428"/>
    <dbReference type="GeneID" id="5854416"/>
    <dbReference type="KEGG" id="mgl:MGL_2491"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2491"/>
    <dbReference type="InParanoid" id="A8Q428"/>
    <dbReference type="OMA" id="HYYGEIK"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Sin3 C-terminal" evidence="3">
        <location>
            <begin position="333"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="729"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="853"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="909"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="934" mass="101448" checksum="9967882AAE4208A4" modified="2008-01-15" version="1">MDADERASFRLKPGLGGQSKSIYQRIIKKVYGRQHGLEVIAALHDNPCVAVPIVLARLKQKDEEWKRAQREWNKVWREVDARNFYKALDHQGVNFKSTDKKTITTKALVNEIESLVATQQQRRLTLDPSLPRLAPRYQLSFAMNDPHVLADVLRLVAHYLDRPSAPFQPHDRARVRQVFKAMLSRMLGMERRSLLALVTPKRARSRREGDGDDDGAGDADDDGDADNNAHGDDDADGDGDSDGNGNGNGEGNGNGDGDGDGDGDGDGDGDGGDSHGDADAHSESELHRAADTENASTSSISHEGEAGKTPVVDTWLVHAPSTAAREMRVSTQLFGNTTMYVFMRLLCLLYTRLASLKHVHIQDQRSISSSKVNPLAANLGLMDTATGPAGLVSTIASRLPGARPLPQDTDTLSDADRAVLTLHPSQYYAVLLELVVRHLRNELDQSSFEEPVRYMYTREGYVVYTIDKVIQALIKTALTINTDAKCQELLDNFASTHRDCAALWADAGIDARDVKLYRRIIASRMAAEHTIGRDEHLFRIEAVPRPPPHVADMSSMMPCELHIQLMSHDDHTLDDPHDQEQRWLQYIASYCLWSPTEGLPTKICAPFLHRNLPASPDSRAVADADDSTRYIVKNNLDIRVCMKTYRLFFVQDTEDVFARIRVADRTAAPSSADDDMPGRQQEEEARAKITAQRTQRWHAWLHARLEAMDETKSTLSTTTDAAAEPLATEADRMPPAVPPASASSPSAGADAPAPAPAPAPAPAPDEHAEETGDVSMVDASPSLPGEERDERDRRRGLAMEHSRDASGPSHTVSTQADATSEAPSEASHAHVSSETPVQRSSSSETVAPTSVDAKTSTTTTITPTPTATAAASEPTTEPASEPAAVAATSAPAQDTRMHDKAEPAAASSRIATDTDSNTQESRPAAPGPETAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4C7</accession>
    <name>A8Q4C7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730142.1">
        <property type="nucleotide sequence ID" value="XM_001730090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4C7"/>
    <dbReference type="STRING" id="425265.A8Q4C7"/>
    <dbReference type="GeneID" id="5854449"/>
    <dbReference type="KEGG" id="mgl:MGL_2524"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2524"/>
    <dbReference type="InParanoid" id="A8Q4C7"/>
    <dbReference type="OMA" id="SHANFVE"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814:SF1">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="144" mass="15807" checksum="673FF404E52E6BB3" modified="2008-01-15" version="1">MPLFVLSPASLAHSALFAGYYTYLSANVGYQRIRTGILDASKSANDEKVQRAVRAHANFFEYTPFTFVLLFLAELNGAPTAWIHAAYSTLFVARVSHGFAMLRPSHQKVLRIFGFAGTIVVMLGAGLYNLGLGYEPLKSFLGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4K3</accession>
    <name>A8Q4K3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730172.1">
        <property type="nucleotide sequence ID" value="XM_001730120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4K3"/>
    <dbReference type="FunCoup" id="A8Q4K3">
        <property type="interactions" value="715"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4K3"/>
    <dbReference type="GeneID" id="5854479"/>
    <dbReference type="KEGG" id="mgl:MGL_2554"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2554"/>
    <dbReference type="InParanoid" id="A8Q4K3"/>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="598" mass="65913" checksum="E5AD4EFE6A2FD24E" modified="2008-01-15" version="1">MSQFKLPNVAADDECWGPRSGPSAASVLPKEFQQIPFAPFSKNDRIGRIADWNSSGTNAEERGGASTMPGRSARSARSAAAPAYSVGAPVNTFAYFHGEDESSFSVVDHARSTAQRRPAAGPAARNGRGAAASGRASGFGRNASSAPGARGGRGGGGSRASGSDARGRRPGWRDWERSQRKTREASITVGPDWEAMGDLDFVRMSKLRMDVEEPEDVGSYGTLYQYDRSYDRVSVRFERQLQPRDRVHYNPTTSEDPVIQDMAAKAKQPQVYMTDSILALLMCAPRSVYPWDIVITKSDDGTLFFDKRANSAMDFLTVNENATEPPIELNDPANGPSPESNARARINTPGTLSLEATFVNENFGFQVCDENKTYNFEHANPFHAADSDEGKLASCGYRYRRFNLGTEENDPVDMVVRTELNAFVAGASDKKPPSQLITIRTLNEFDSRAPGAGGAPDWRSRLDQSRGAVVATEMKNNSFKLARFAVQSILAGADNMKLGYISRLNPLDPYRHTILGTSWFKPRELAAQMAYSLPNGWGIVRTIIDVVRAQRPGRFVLAKDPNKQVVRFFRVPWDFEQQDEDEEEEDDDDDGEEGPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4L6</accession>
    <name>A8Q4L6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730185.1">
        <property type="nucleotide sequence ID" value="XM_001730133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4L6"/>
    <dbReference type="FunCoup" id="A8Q4L6">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4L6"/>
    <dbReference type="GeneID" id="5854492"/>
    <dbReference type="KEGG" id="mgl:MGL_2567"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2567"/>
    <dbReference type="InParanoid" id="A8Q4L6"/>
    <dbReference type="OMA" id="NKKKWMI"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="8">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein uS3 C-terminal" evidence="7">
        <location>
            <begin position="107"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="264" mass="28819" checksum="864460D91B96F2C8" modified="2008-01-15" version="1">MASAIISKKRKFVADGVFTAELNEFFTRELAAEGYSGCLVRVNHVRTEIIIRATHTQEVLGDKGRRLRELTTLVRQRFRFPEGSLELYAEKVANRGLHAVAQCESLRNKLLGGLPVRRAAYGVLRYVMESGAKGCEVVISGKVRGARAKSMKFNDGFMIHTGQPAKDFVDVAIRHVLMKQGVLGLKVKIMHGWDPEGRSGRPFPLPDAVTILEPKEDEPITAPMSESRNQPVASAETAPAPASAMPGAQETPAYTQAAPHAAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4N6</accession>
    <name>A8Q4N6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730205.1">
        <property type="nucleotide sequence ID" value="XM_001730153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4N6"/>
    <dbReference type="FunCoup" id="A8Q4N6">
        <property type="interactions" value="873"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4N6"/>
    <dbReference type="GeneID" id="5854510"/>
    <dbReference type="KEGG" id="mgl:MGL_2587"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2587"/>
    <dbReference type="InParanoid" id="A8Q4N6"/>
    <dbReference type="OMA" id="EAMDQSI"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001069">
        <property type="entry name" value="Related to GLE2-required for nuclear pore complex structure and function"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="98"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="364" mass="40184" checksum="58F3E4BFDF5EA62F" modified="2008-01-15" version="1">MHVVLAAPVAVRRNQAPREPLAFSPTADVLAVASWDTFVRIYRIDKTNAQPVQPHQQYQHEGPVLDVCFNADGSKVISVGADKVARCFDLNTNQAAIVAQHNDTIRCVRWLRAFGGALVTGSWDKTVKIWKIEPQPTLITSLDLPERVYAMDVIGLIVIVAMAERKIMAFQCNEATGTAQQVVDQFSPLKYQTRSIAALPDGDGFALGGTEGRVAVHYFHDPPDPKDGKVKKFAFRCHRRTNADHPDVPRNETQLYPVNAIAFNAQGTFATGGGDGSISFWCKASRTRLKTFETKGAAMAPKELFKTNPNRLPVTAITFNADASIFAYALGYDWHKGYQGATSETHVFIHPVNPEDIKKRPPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4U9</accession>
    <name>A8Q4U9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730262.1">
        <property type="nucleotide sequence ID" value="XM_001730210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4U9"/>
    <dbReference type="STRING" id="425265.A8Q4U9"/>
    <dbReference type="GeneID" id="5854567"/>
    <dbReference type="KEGG" id="mgl:MGL_2644"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2644"/>
    <dbReference type="InParanoid" id="A8Q4U9"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="110"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="159" mass="16877" checksum="720DB495F3EE10EC" modified="2008-01-15" version="1">MREKLANKRVQCRLCKGDHYTARCPYRDTLEAIPGAGGDVPDSDTVAAAAAAGVSLTSEGAAAAGKMNPVSAALGAAVANAPGKYKPPSLRSGAMPSHGMGGPTQRDESATLRVTNLSEDVEEEDLRDLFRRYGRVTRIFVGRDRETGLCKGFAYVNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5A6</accession>
    <name>A8Q5A6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730383.1">
        <property type="nucleotide sequence ID" value="XM_001730331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5A6"/>
    <dbReference type="STRING" id="425265.A8Q5A6"/>
    <dbReference type="GeneID" id="5854688"/>
    <dbReference type="KEGG" id="mgl:MGL_2765"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2765"/>
    <dbReference type="InParanoid" id="A8Q5A6"/>
    <dbReference type="OMA" id="CGINPGT"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="4">
        <location>
            <begin position="29"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="272" mass="30505" checksum="BEC582F2AC8DABA2" modified="2008-01-15" version="1">MGRAPRSKTAISAEARIISPYFAGGQRLPDYIKPNLDVVFCGINPGTESGAQRRHYAHRSNHFYACIHMAGLTSERLTPSQDMTFPTLQPYRLGLTNLAHRPTARSEQLTRIELERGVPELLMKIARYRPRVICFVGKQIADVFMRVVRASHTSGTVRVPKPLGVLGFWHKSENCEHSDKDRSDGNGDYMYIPKVDVGYGVLPICMPHEQTTINTLFFVTPSTSARVTQHQLPGKVRIMSYIPKLLEYGSSNLSDESRHHVDMLRLCAPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5L8</accession>
    <name>A8Q5L8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphomevalonate kinase</fullName>
            <ecNumber evidence="2">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2793</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729807.1">
        <property type="nucleotide sequence ID" value="XM_001729755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5L8"/>
    <dbReference type="FunCoup" id="A8Q5L8">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5L8"/>
    <dbReference type="GeneID" id="5854108"/>
    <dbReference type="KEGG" id="mgl:MGL_2793"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2793"/>
    <dbReference type="InParanoid" id="A8Q5L8"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727230" description="phosphomevalonate kinase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="8">
        <location>
            <begin position="250"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="400" mass="43315" checksum="611F7C0E3B3AA026" modified="2008-01-15" version="1">MTTSLVAALLLHLNAITVSVEDDGQLTTRSLGLVHNVAQLAHCAAQGKVGSGFDVSASVWGHQLYRRFDPALIKDLMYPEVGSRIITSQENISHEKRPLLALLPILDPRNPLWVPAPPPSATTTAIEGLAMLRTGTEEARKARPAPLPLPPGVRMCLADVDTGSNTRTMVGRVSDWRRQNPIWADQLYKIIATSNQSLADGLLQLHMAYVNDSSNYTQVLEGLSHLPSKEWDLHLKSDLSPVYEIFVSVRNAMRSIRAGMRELGLRSGAPVEPPEMSQLLDTTINGAPGILGGGIPGAGGYDAMFLLFLDPASLTASAPSQPMHPPKDVCDLWLTYRDLSVGPLLCGSDDITSSYVASLKDRQEDVLSYISRVWAHAPVGLHVVSSSEVPGLERVLRSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q666</accession>
    <name>A8Q666_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729876.1">
        <property type="nucleotide sequence ID" value="XM_001729824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q666"/>
    <dbReference type="FunCoup" id="A8Q666">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q666"/>
    <dbReference type="GeneID" id="5854183"/>
    <dbReference type="KEGG" id="mgl:MGL_2862"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2862"/>
    <dbReference type="InParanoid" id="A8Q666"/>
    <dbReference type="OMA" id="TRFCAYF"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="262" mass="30171" checksum="6C5C62AA3D4AEB1D" modified="2008-01-15" version="1">MSWGGFKKSINRAGTQLMQKTGQLERSDDSRFKEEEHKYRELEKHASALLKCSRDYLDSIRLLSASEARIGDTIEGFYHDNSEPAIIATSYKRALEELDARTAKELDAPYRATVLDPIGKLCSYFPEVNKLIDKRGRKLLDYDATRSRYKKQSDRPSDDPSKLPRMESEHNEAKLVFDALNEQLMTELPQLVDMRIPYLDPSLEMMIRVQIKFAQEGYEQLGGVQRYFPEQVRTDYAEGQLDAQVESILQEMRGLSICGMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q680</accession>
    <name>A8Q680_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2876</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729890.1">
        <property type="nucleotide sequence ID" value="XM_001729838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q680"/>
    <dbReference type="FunCoup" id="A8Q680">
        <property type="interactions" value="402"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q680"/>
    <dbReference type="GeneID" id="5854197"/>
    <dbReference type="KEGG" id="mgl:MGL_2876"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2876"/>
    <dbReference type="InParanoid" id="A8Q680"/>
    <dbReference type="OMA" id="DYADQEM"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="206" mass="23095" checksum="0573C731A3E66168" modified="2008-01-15" version="1">MSIVHLQNVEIINSKARFSDPYIFKVTFECISPLEDDLEWKLIYVGSAESEEYDQELDSCMVGPVPVGVNSFEFEAEAPSSEKIPASDLLGVTVILLTGSYKDAEFIRVGYYVNNDYESEELRENPPEQIQLDKVCREVLASKPRVTRFNINWDNPKEMIKPPEEPSTQAEQNDTTVDAVESTPNPMFRPAPDSGSGSSAFVPFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6B0</accession>
    <name>A8Q6B0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit beta</fullName>
            <ecNumber evidence="13">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2906</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="13"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729920.1">
        <property type="nucleotide sequence ID" value="XM_001729868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6B0"/>
    <dbReference type="FunCoup" id="A8Q6B0">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6B0"/>
    <dbReference type="GeneID" id="5854227"/>
    <dbReference type="KEGG" id="mgl:MGL_2906"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2906"/>
    <dbReference type="InParanoid" id="A8Q6B0"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="110"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="439" mass="47384" checksum="FF9800B74D3F41EC" modified="2008-01-15" version="1">MKNGGRLVLEVAQHLGENTVRCIAMDGTEGLVRGQKVLDTGAPITIPVGDGTLGRILNVIGEPIDERGPVKTDSYRPIHRDPPAFVEQSTDAEILETGIKVVDLIAPYARGGKIGLFGGAGVGKTVLIQELINNIAKAHGGFSVFTGVGERTREGNDLYHEMIETGVINLEGDSKVSLVFGQMNEPPGARARVALTGLTVAEYFRDEQGQDVLLFIDNIFRFTQAGSETSALLGRIPSAVGYQPTLSTDMGSMQERITTTRKGSITSVQAVYVPADDVTDPAPATTFAHLDATTVLDRSIAELGIYPAVDPLNSQSRMLDPDVVGQEHYDVASGVQKLLQDYKSLQDIIAILGMDELSEEDKLTVERARKMQRFMSQPFAVAQVFTGIEGRLVALKDTVKACKEILSGKHDQLPEAAFYMVGNIEDVLAKAEEISKQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6C4</accession>
    <name>A8Q6C4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2920</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729934.1">
        <property type="nucleotide sequence ID" value="XM_001729882.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q6C4">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6C4"/>
    <dbReference type="GeneID" id="5854241"/>
    <dbReference type="KEGG" id="mgl:MGL_2920"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2920"/>
    <dbReference type="InParanoid" id="A8Q6C4"/>
    <dbReference type="OMA" id="MRQHSAK"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="13">
        <location>
            <begin position="1207"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="12">
        <location>
            <begin position="1937"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="14">
        <location>
            <begin position="2268"/>
            <end position="2300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="2300" mass="260518" checksum="2F4C6F574EA27D9C" modified="2008-01-15" version="1">MLSELKGERLQAFSNELNRRVIELTHSAQTASKLGGITAIDNFIGLESEDNSARLYRFYQYLKPNLPCSDPQVMFAAARVLGRVSKHGGHSLGDQFVEFEMQRALDFLQGERNENGRYAAVLIIKEMARNVPYLFHTYVGRVMDHIWVALRDAKVAVREAAAEALGACFQIISDREKQMGTQAYELVYDDAEQGLRDTAVEVIHGSLLAILKLLRYSKMFMKTRLHRTCELILRLHRHRDPLVKRTVTNLIPVLAAYDPPYYAQEYLGPVMTTLIDQLRRERDRSTKEAWGDTLEAIGLVSMAMGDRMQPYVDSIMQCVRESLLLRGKKNMPPEGPVFFCLGHVALAVGTRIERDVHDMLDMMFACGLSTALVSALEKIVHAIPALLPIVQERLLMMLSYILIGVPYRPLGAPLPRHGGRPPPVLHVSPDAKTIETLTIALQTLGSFDFSGHILNEFVRNCTLPYLELDAKDVRKAAAMTCAHMYVNDPICYQTSMHAIEVFNDVLDKLIMVGIADPDAELRFTVLSALDEHFDRHLAQTEYIRAIFIALNDEEFAVREVAINILGRLAKYNPAYVMPSLRKVLIQLLTGLEYATVTRHKEEAAKLLTGVVRALQGLVKSYALTILQVLLPKANDAHAGVAARVTECLGELARVAGEELAPLVDELVSLMVSQLSSGSVHASVAKRDAALKTLGRLASNTSHVANPYLQYPRLLGALVKILKTEQAAPVRRETIRVLGILGALDPYRHKLLESTMDPVVTAGGSQTDLFELATLIGTSTDEYYQNVAIEALIAILRDPTLSVHHHAVIEAIMYMFKTQGLKCVAFLPQIVPAFLGVIRTCAGGGLSEFYYQQLAILITIIKQHVRNYLRDIFALVQADWNPNSSIQLTIVALMEAVARALEGEFKAYLPLLLPNLLQTLEGEITPKRMPTLLRMLQAFYVFGANLEEYMHLVLPVLVGLFERADAPMVLRRAAIVTVGQLSRKVNFADHASRIIHPLVRVLQSGVAELRVPTLDTLTALVFLMGPVYMPFVVVVNKAIVQQRIQHPRYQQVVAKLLRSEPLPLELLPPDTLALDKADEAPHAEASKMAVNQLHLKAAWDTSRVSTAQDWREWLRRVAVEMLRESPSHALRACRSLAEVYHPLALELFNAAFVSCWVELYDTYQESLVHAIETALDAYEIPDQVVHILLHLAEFMEHDDKALPISIRLLGDRAYKFHAYAKALHYKEAEFMAEPTPQIVELLIDINTKLQQGDAAFGALTYAREHMDITHHEEWYEKLHRWEEALAAYERRALEQPDAQEIVFGKMRCLHALGEWEHLTELVQAKWPTAGPDGRRQMAPLATAAAWSFGQWDIMDEFIAAMRPESSERSFYRAVLAVHHSQRHQTKRLIARARDALDTELTALISESYGRAYDLMVRTQMLSELEEALAYKLDYAEQPDRQATMRTIWMKRLQGCELDVEVWQRILSVRSIVLTPADDMDTWIKFANLCRKSGRMVLAEKTLNSLLGPEVHALDSPLAGPKAPPAVIYSHLKFMWACGARAESLCYLRDFTMNLAEDLGMASVDKQDNLVLPDIRASPRLAEFAKLLARCFFKLGEWQVAMNEEWVVDDNYDVIRSYKRSTELDRDWYKAWHAWALANFDVITHHERHGVAIPFHEVAASIVPSVHGFFRSISLASGNSLQDTLRLLTLWFKFGHLEHVADAVRQGFSTVTVDTWLEVIPQMIARISAPSPRVRRLIHHLLSDVGTAHPQALVYPLTVATKSPSPVRMHAAMGIMDTMREHSPVLVEQALLVSNELIRIAILWHEMWHEGLEEASRLYFTEHNIEGMFATLGPLHDLLERGPETLRETSFAQTHGRDLNEAREYVRRYRQYGEINDLNQAWDLYYHVFKRITKQLPASNSVQLALQYVSPKLLAMRDLELAVPGTYVSGQPIVRITQFEPVVLVISSKQRPRRLKIRGSDGRTYQYLLKGHEDMRQDERVMQLFGLVNTLLSIDTESYKRRLNLRRFPVIPLSPNTGMLGWVANSDTLHILIKEYREQHKILLNIEHRLMLQMAPDYDNLTVLQKVEVFEYALDNTPGQDLYRVLWLKSRSSEAWLERRTAYMRTLATSSVAGYILGLGDRHPSNLLLDRQTGEIIHIDFGDCFEIACHRPKFPEKVPFRLTRMLIKAMEVGGIQGTFKVTAENTMRVLRDNRESVLALLEAFVHDPLISWRLVTDSDAEQRAPDAHEHEHEVAGEIRGVEGEARNQRALEVVRRIQNKLTGRDFHPNISLSVPEQIERLIQDATSIENLCVAFIGWCAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6E4</accession>
    <name>A8Q6E4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2940</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729954.1">
        <property type="nucleotide sequence ID" value="XM_001729902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6E4"/>
    <dbReference type="FunCoup" id="A8Q6E4">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6E4"/>
    <dbReference type="GeneID" id="5854261"/>
    <dbReference type="KEGG" id="mgl:MGL_2940"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2940"/>
    <dbReference type="InParanoid" id="A8Q6E4"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="3"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="13">
        <location>
            <begin position="379"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="13">
        <location>
            <begin position="551"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="701" mass="78090" checksum="3F60DF99C6D7BFE3" modified="2008-01-15" version="1">MRCGIFAYVNYLVEKDRQYIIDVLVNALSRLEYRGYDSAGLTVDGDREKEVLLFKQVGKVHALRKHIAESSVDMDRTFVSHAGMAHTRWATHGSPSPLNCHPHKSDPKGEFTVVHNGIITNFRELKLVLEKRGYTFETDTDTEAVAVLVKYFWDSYPENRKPDFHTVVRCAVKELEGAFSFVFKSVYFPGEIVVARRGSPLLIGVKTEKKLKVDSVDVQLGNQVEGDYANVPNLHSAPNFDQPGAPQPAAPGSIDKLIRSQSRAFLSEDGMPQPIEYFIASDASAVVEHTKRVLYLEDDDIAHIADGELHIHRLRRNDGLSSTRSIETLEMELAEIMKGQFDHFMQKEIYEQPESVVNTMRGRVNFDTRQVRLGGLVAYLNVIRRCRRIVFIACGTSYHSCLATRAIFEELTEIPVSVELASDFLDRKSPIFRDDVCVFVSQSGETADTILAMRYCLGRGALCLGVVNTVGSTISRETHCGVHINAGPEIGVASTKAYTSQYIALIMMAVHLSEDRLSKMGRRHEIIDGLHALPDQIRTVLSCDKQYQDLAYNILVNEKSLLIMGRGYQHATCLEGALKIKEVCYMHSEGILAGELKHGPLALIDEAMAVILIMTKDSLYPKVQTALSQVSARNGRPIIICNEDDNNVPNDARAIRVPLSVDCLQGLLTVVPLQLLSYHLATANGVDVDFPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6Q5</accession>
    <name>A8Q6Q5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730046.1">
        <property type="nucleotide sequence ID" value="XM_001729994.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q6Q5">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6Q5"/>
    <dbReference type="GeneID" id="5854353"/>
    <dbReference type="KEGG" id="mgl:MGL_3032"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3032"/>
    <dbReference type="InParanoid" id="A8Q6Q5"/>
    <dbReference type="OMA" id="EVMCAYI"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="767"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="730"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1156"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="730"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1160"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1180"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1911" mass="208853" checksum="C65A47EA7E3B9427" modified="2008-01-15" version="1">MEVDEPTVRPPSEAQPDAVNAGPETAIQREDHARGDSVDADKNEDDAHRTNETSVAEMTSAKPKDSMQNLDANGENERSEGAEATQNTDSAPGVAESTHHDHVPGGGDDQETGSVIDKLHDQHDGQRSAREMDETELVKPEADSGIVNSEDAGVSPITVAQQEKEEAKAPTPLPKSPSPSPSPAPVPVVAISAATAAASSSSPSPSPSTIGTERTMHHSVSSAKSLTRGGAVFVVSALETISSSKEARRNKALKESATTALDMVRRATSGPDTQETPVVLDPRVVFEPLRQACASKSVGLQTTSLDCIAKLVSYAFFAEDDAGTYAQTAESPLADLVVETVCDCFDDQLDERVSVQIVKALLACVLSVSIRVHQSSLLRSVRTVYNVFLMSRTPVNQGIAQGALNQMVGAVFSRMPLEEAHGEPTDTSTSAEPVTLQMLESRHSLDAGEKDEASLPMDAPDLLVKDAFLVLRALCKLTMKPLSSESERDMKSYSMRSKLLALRTVKGVLQQHMHVFTTGTVRFHSTTSGGESTFVQAVKQYLCLCISRNAVSSVLPVFEESCEIFWLVLSGMRNKMKKEIEVLMNEIYLPILEMRSSPMAQKLVLLHTLLRLCKDPQALVEVYLNYDCDRTALENLYERLMNVISRLTQMPGSEGAQVPDERKEAESVDVRLKRHSLECLCSVLRSLVEWMGRLIEEPVGSTDEGAAHADDAATGSSTAASAAPASAASASASTSTSTSASTSASASASASASTAAAPPGMDDDPGRFENAKQRKTVLLEAIRTFNFKPKRGIAQLIEHGFIRGGEPEAIARFLFYADGLSKRSIGEYLGEGDAHNIATMHAFVDLMQFDHMPLTTALRRFLQAFRLPGEAQKIDRFMLKFAERYTDGNQTAFANADTAYKLAYSVIMLNTDAHNPQVKHRMTLQDFLKNNAGLDDDRDLPEEYLTAIYDEIQKNEIKLYGEEAPTVPTSGGLAGVIATVGRDLQHEAYVLQTQGMANRTEVLFRTMLHAQQQAGVQRALAERYFSASHMEHVKPMFEVAWMSFLAGISAPLQNSNDADTIRMALDGFKDAIKIVCFFGLELERNAFITTLAKFTFLNNFGEMKSKNVATIEALLDIAHTEGNFLQGSWREVLTCVSQLERFQLISGGVDERTLPDLGRRPVVVPSPGSSGATPASTMQASGVAATTIATSSTSSTSRGTSHMPHEDEIQAGASSEITVTADRVFSATPQLSGEAIVDFVQSLCDVSWEEIQSSGLSDKSAAVLAAKGRSKSPTTTWGASAWSGRVCGQSLGEHFYHVCCHPNPAVSAFGLDSLRQLASKFFEKEELLHFTFQKDFLKPFEYTMRRNADTGAKEMVLQCLDQMVQTRAERIRSGWTTILSVFGVAASATERIALFAFELVRRVQQQHMHAILVNGSFADLCVCLAQFGKVTNQRVSLPATELLKSIVPASMQAAHAADTPAKSLWLPMLFSLYDILMTGDDLEVRRVALDALFSILVEQGGTFSMTFWDQVCNDVLFPIFNVLRNRSDVTRFSTQEDMSVWLSTTMIQALRQLVALWTHFFHTLKPRLPGLLELLCACICQENDTLARIGTSCLQELIIHNMAQMDDTCWQQVVDAFLRLFRATTASQVFDPALSSPDDPLPAHERRHAFKQIIVKCVLQLLLIETSNELLQNTEVYEAVPVPQLLRLTAALEDSYRFSRRFNADRTLRTSLWKVGFMKQLPNLLKQESTSASTLVYVYLRMHNDHRAGFAAHRAEVSERFLPLAEEIISVFLPLDNETQARNISAWTPVVAQVLLGLASMYEMDPHAHKAATPTFYLLVIELLDKISLAPALTGPLRRYLAAVGAAHGLIDKDAAVARARARDEARAEMLQAAPLGHTQVAADQSQADLRHMALSNPSVDAFASPTTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6R6</accession>
    <name>A8Q6R6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730053.1">
        <property type="nucleotide sequence ID" value="XM_001730001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6R6"/>
    <dbReference type="FunCoup" id="A8Q6R6">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6R6"/>
    <dbReference type="GeneID" id="5854360"/>
    <dbReference type="KEGG" id="mgl:MGL_3039"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3039"/>
    <dbReference type="InParanoid" id="A8Q6R6"/>
    <dbReference type="OMA" id="NGWIEAC"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="40"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="572" mass="63699" checksum="9D014C2CC1500B37" modified="2008-01-15" version="1">MKALLDLRNNLKDRGTSGPKQHRSLSALSASQKNEASLRPPQKVLRAHTDYNSQSPHEISFHKGDFFHVLSDIEPSQNGWIEACNPVTNSRGFVSLSYFDVLSRTTPRSTIPLTAHSELNPGFRPSSQSSAGSQRSTFSSSDYTSNGTFATIKYDFKAELPHELSVKEGDGVFVVARSNEEWLVAKPLEYVGMPGLIPTNYITFCDMRTGKPLTHEDNISVLSGIPSVYEWGVQNNRAHQQTLSLSSAQDPLPQDSSSPYVEDKVSSKQFPQTPQCSYNMDDYFSSLDSFSPNEQTLHSEATSTARPVLPLSVKLAFVSLDLLLADSYGQWVRLHVVYSVKCTPPVMSEYYERRELVLFRLYHDFAKLRHSLELDLTRSMPTLTQPVALPILPPIDHEGRALKAFVIALCALPNQVLQEASIQRFLEVRAADYCHVTVSHDGNTRDVSLKGSLSNNRSLGSQDSFEHHNSARSSTNTKYSASDSTSLSDFSHHRIKVVHRGERSKVIALRISSTVSYELLVQKVRDKFGSAIQSLEFAETPGQCRICDDEDLRAWLTASLCAGNKLMLYASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7N1</accession>
    <name>A8Q7N1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729543.1">
        <property type="nucleotide sequence ID" value="XM_001729491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7N1"/>
    <dbReference type="FunCoup" id="A8Q7N1">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7N1"/>
    <dbReference type="GeneID" id="5853849"/>
    <dbReference type="KEGG" id="mgl:MGL_3087"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3087"/>
    <dbReference type="InParanoid" id="A8Q7N1"/>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="740" mass="79971" checksum="0E7681898E0D5205" modified="2008-01-15" version="1">MSIATHNDEDKCFTRLDELERFNFFPRESHVEAESRRRPKKAECFGRRVHVGSYKKRKSATSFATQRYPEGIPLNTMIGALTRGLRMAPTSGRLLSQSLRASSVGGVRFNSGKVSGPVIGIDLGTTNSCVSIMEGQQARVIENSEGGRTTPSVVAFSKDGERLVGLPAKRQAVVNPEATLFATKRLIGRKFTDREVQKDIDNVPFKIVAHTNGDAWLEARGQKYSPSQIGAFIVGKLKDTASGYLGKSVKHAVITVPAYFNDSQRQATKDAGTIAGLEVLRVINEPTAAALAYGLDRQDSATIAVFDLGGGTFDISILEMSKGVFEVKSTNGDTHLGGEDFDIVVVEHLVKEFQKENGIDLSKDRMAIQRIREAAEKAKIELSSTSSTDISLPYITADASGPKHINTKMTRAQLESMISKLIQRTVEPCNKALSDAGVKPTDVNDVIMVGGMSRMPKVLETVKSIFKREPSKGVNPDEAVAIGASIQGGVLSGHVTDILLLDVTPLSLGIQTLGGVFTRLINRNTTIPTKKSQVFSTAADGQTAVDIQVYQGERELVKDNKLLGNFQLTGIPPAPKGVPQIEVTFDIDADGIVNVSAKDKATNKDQSMTIAAGSGLSDQEIERMVNDAEQHAEADKARRVVIEEANRAQSVASETSKAMGEFKDQIDKEEAEKVQKLVEELEAIASRGVTGDDGVNADEIKAKIDETQQASLGLFKKVYESRSQADNSSGNNSGEGEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7S4</accession>
    <name>A8Q7S4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MGL_3104</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729560.1">
        <property type="nucleotide sequence ID" value="XM_001729508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7S4"/>
    <dbReference type="FunCoup" id="A8Q7S4">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7S4"/>
    <dbReference type="GeneID" id="5853866"/>
    <dbReference type="KEGG" id="mgl:MGL_3104"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3104"/>
    <dbReference type="InParanoid" id="A8Q7S4"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="45"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP42346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="288" mass="32163" checksum="BC6A72C1B1DB54FB" modified="2008-01-15" version="1">MAIVPSSLRVAMRANAPRMLGAATFSTSISSAMASPAAERPSKMKAFKIYRWDPENPAQKPHMKTYNIDLNQTGPMVLDALLKIKNEQDSTLAFRRSCREGICGSCAMNIDGVNTLACLCRIDRDASQSNIYPLPHTHVVKDLIPDLTQFYKQYRSIEPYLKPAGPPPGGREYLQSPEERRHLDGLYECILCACCATACPSYWWNGDAYLGPAVLMQAYRWMADSRDAHGAERRERLENTFSLYRCHTIFNCTRTCPKGLNPARAIAQIKKDMAMGAPADVDRPLQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7X5</accession>
    <name>A8Q7X5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729607.1">
        <property type="nucleotide sequence ID" value="XM_001729555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7X5"/>
    <dbReference type="STRING" id="425265.A8Q7X5"/>
    <dbReference type="GeneID" id="5853913"/>
    <dbReference type="KEGG" id="mgl:MGL_3151"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3151"/>
    <dbReference type="InParanoid" id="A8Q7X5"/>
    <dbReference type="OMA" id="ARFYQHN"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000006">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="766"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="87746" checksum="24788ECEE522E7AB" modified="2008-01-15" version="1">MSLPPQRYQDEPPEQKRRTSLKDVDLNWGGTAESIFNEDAQREQDLDAARLMSQANADIAWMDDEEAKLSTPHAAAQKVSRNHAVAAAAAASRQFYQQNAGSSTSVDSQNHFIDHRNQSHSLSVNPHSPLAARAMQGTSSMHDHPTENSPYATKPAPALCNQPVENMPPSNTPVPLVNIDSAASSWEPRVDGLNNLAQSTITDSSRPLEDDVCFPPPTQVDQPAVDSKHESSKYKGEKPGFPYTFDLSILEEFAKEERENFGNASSWPPASSFGSSARPGQGGQFGYTTFPFSGATNGDSMLYSRRPRRAQTSGMETGAGGSKYQKKLAMFEGGQSFGRAPDSKEVSALTSGIDSKNESVQPLLQGSAKTSYQGVPGSEARPSTLSRAQTIPRAPRSTIPIPGALHDKPYRFTFYSNAFPTSLHARFLSELPGPGQTFEDLIRGVPSDDPPEKPRTTGTSAGSQPLPQIPLMGHARDATESEANTWWLDVLCPTDQEMKILARTFGIHPLTTEDILMEETREKIELFRNYYLLCFRSFDQDPYSPTYLEPLNMYIVVFREGTLSFHFRQTPHPHNVRRRIKQLKDYINVTSDWISYALIDDITDAFAPLIQSIEFEVDSIDELVLILKEAEQSDMLRRIGTCRKKVMGLLRLMGNKADVIKGLAKRCNEYWSIAPKSDIGMYLSDIQDHLITMTQNLNHYELILSRSHSNYLAQISIEMTDANNQINDVLSKLTALGTVIVPMNVITGLWGMNVQVPGQNVQNLNWFGGICAVMVVIAVTGYITTVRYLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q807</accession>
    <name>A8Q807_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729631.1">
        <property type="nucleotide sequence ID" value="XM_001729579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q807"/>
    <dbReference type="STRING" id="425265.A8Q807"/>
    <dbReference type="GeneID" id="5853937"/>
    <dbReference type="KEGG" id="mgl:MGL_3175"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3175"/>
    <dbReference type="InParanoid" id="A8Q807"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="149" mass="16836" checksum="5C0E421E099CAC6E" modified="2008-01-15" version="1">MKVQVEVDTILFDMDGTLIDSTPALNATWAEFANEYNLDIDYVVCGKTLNLQKLHYSHGHRTVENLKRYIPTLEDDALMKEVVRFESRILDIARENLERSKSTGQTDGTIIAMPGARELLAQIQQGREANPRRRSGWAIVTSGTFCSCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q880</accession>
    <name>A8Q880_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729677.1">
        <property type="nucleotide sequence ID" value="XM_001729625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q880"/>
    <dbReference type="FunCoup" id="A8Q880">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q880"/>
    <dbReference type="GeneID" id="5853983"/>
    <dbReference type="KEGG" id="mgl:MGL_3221"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3221"/>
    <dbReference type="InParanoid" id="A8Q880"/>
    <dbReference type="OMA" id="HRWNYAS"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728015" description="SUN domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="8">
        <location>
            <begin position="293"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="587"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="640"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="861"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="948"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="900"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="972" mass="105889" checksum="2F242632E1DEDDC8" modified="2008-01-15" version="1">MNRTVPYGIWSACVLALWLGITASANNVDVKITTSPPSPQHRQPAELPGEPSPLGPVFRCYSPNAPDHEPTSQDVAEVFDSSVTFRTDPRRMLLSNDIFFCEVPTQDELGRWHTRMYAVFGTVMVPRNDAPASLSTSPVHRAHEIDPGAAAAAAGVAQSEAEQRAKMHVDDPLLSFDEWKEQHLEHARKLRKSDKARERAAHKSQVSGSDVRSFDKSAFLAASLSGSSSSPSATSTSEVARSPDREGDESTRAAHAESAAADVAQGAAQAAYNQTMLDASASMDQNAPADPGPPHIYAQEDASAGLAELKHRWNYASLDCAAILHKANPFAKSASAILSEKKDKYMLSPCPWSAGYQGDKSGRPESQFVIVELCQQIRVDTIVLSNLEFFSSMFKLFAVRVARSLHAPEDEWHTLGFFHARNARGYQVFKLSSAPQSYFRFLRIDFLEHYGTEFYCPVSLLRVYGRNEREDADDDMMDDINALDDDDVSDMLDDTVPSEPLLELASTHAIDGNRVVERACEREPFPGLWRPVCERVLPVVLPPPPLSMPTGLATNDSYSLMASQVPPPLDPFVPLLVDDMPTMCMSTSSVATTSSPDPVAGRPVSTSQPSSPPSSTVSTDLSVEQQTTWTSATWTATATAATSSSTMMPPPSSPRTTSTASLSEPPSPSTSLPPTSSSVTAAGGDLHTSSLLDGTSETRRTAEPKGNAAKPKSSNKPQGDTKSGGSESIYRTITKRLVALEANTSLSMQFLQLNSQKLRDKLLVLEQMQETRLAEMFAAMNASQARVWGDKVGQQQSALAALEAQQQSFEEERTILLARIERLAADVRSEKRWGMAQLSLLLILLLILALTRSPTNLAHVAPQSGEYKSPPSLLHAPNSTEASPHPIDNMEYDSGEPLSAMSTPGRSSSFTLTPRPVASLQRARRRYATPSTLIRARRLRLNGAKYRRLSDTHTPHMMPDPTATEWTEKDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q896</accession>
    <name>A8Q896_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729686.1">
        <property type="nucleotide sequence ID" value="XM_001729634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q896"/>
    <dbReference type="STRING" id="425265.A8Q896"/>
    <dbReference type="GeneID" id="5853992"/>
    <dbReference type="KEGG" id="mgl:MGL_3230"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3230"/>
    <dbReference type="InParanoid" id="A8Q896"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="48"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="52"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19388" checksum="451603C54B170436" modified="2008-01-15" version="1">MGLSSLTEDEILKAAVSKYGMNQWARISSLLVRKTPKQCKARWYEWLDPSIKKIEWSREEDEKLLHMAKLMPTQWRTIAPIVGRTATQCLERYQQLLDDADAQESELGLAGTGAEAGPSADTSAQAAARRSGSRPRVKTSETRSHRYGRRRKGNALGGACASCQHGRQKSEAQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8F6</accession>
    <name>A8Q8F6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729718.1">
        <property type="nucleotide sequence ID" value="XM_001729666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8F6"/>
    <dbReference type="STRING" id="425265.A8Q8F6"/>
    <dbReference type="GeneID" id="5854024"/>
    <dbReference type="KEGG" id="mgl:MGL_3262"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3262"/>
    <dbReference type="InParanoid" id="A8Q8F6"/>
    <dbReference type="OMA" id="CGAVENN"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="3">
        <location>
            <begin position="39"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="264" mass="29707" checksum="E669558410DB7A9D" modified="2008-01-15" version="1">MDDDNIDMAPAPDLAPEPASNPVSEPPSAQAPRARRSIDERQRGRRLFGMLHSTLTQARDAQTPTRHASSHPDQDRRQDVSSPPSAPEAALTSTSQASARQQDSHEAERRRHDAERASMRQKAQRVRDLAESLVAFEMAHRMARANKRRLSSFLVTHTKKNASNSNALAPRDAMEVTATTAARIVPQVPLCGAVENNAMLTADYEVYYLPRKLLPTQEDALDEQEERVDEDMDKADDDWDQAREAMQKELQETKAELMRHHVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q938</accession>
    <name>A8Q938_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein kinase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729369.1">
        <property type="nucleotide sequence ID" value="XM_001729317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q938"/>
    <dbReference type="FunCoup" id="A8Q938">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q938"/>
    <dbReference type="GeneID" id="5853676"/>
    <dbReference type="KEGG" id="mgl:MGL_3404"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3404"/>
    <dbReference type="InParanoid" id="A8Q938"/>
    <dbReference type="OMA" id="DEMGYSK"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="79"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="234"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="494"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="70567" checksum="C4AF9B67EA09AD10" modified="2008-01-15" version="1">MTPKARAVDQNPFDLLQERITSSRAGAMGLIGSDRSVDRASVPSVLITPGHAQGQMSTLACANEPTISKETSDFLIKLPPPKPRAEPKDVTRNTGSARGCLRVQVIEGRNLTVASQTLSHPYAVLQFDKNEYIGKHISKMAVGAHPVWNETAAFDVTIENQSLHLSVYDRIGDTEELVGACEVFPRLFHRSTTKRWYTLYLLKDDGEEQLVRGDVQIQMEYERLPLRKLSPRDFEFLKLIGRGTFGRVFQVRKKDTKRIYAMKVLSKREIALKKEVTHTMGERKILEKSQDCPFLVGLKFSFQSETELFFVTDYKSGGELFWHLQREGRFTEARAKFYVAELILALEHLHKYGIIYRDLKPENILLDATGHVALCDFGLSKADLGAGQLTNTFCGTTEYLAPEILLDEMGYSKLVDFWSLGVLLFEMCCGWSPFYAEDTQQMYRNICFGKIKFPRGAITDDGKQFVKGLLNRNPKHRLGAQNDAQDLKDHAFFRDMDWDALAHKRIPPVFKPLVDSNESVANFDPEFTNANISEVARFAFQNEEPLDEELDDAMKKKMHLTSSAKNGVDIQKHERGKTDELLSSSVQEKFRGFSYTGSYEDSSSIMEQGVHAIDWGREPRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q982</accession>
    <name>A8Q982_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3431</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729396.1">
        <property type="nucleotide sequence ID" value="XM_001729344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q982"/>
    <dbReference type="FunCoup" id="A8Q982">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q982"/>
    <dbReference type="GeneID" id="5853703"/>
    <dbReference type="KEGG" id="mgl:MGL_3431"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3431"/>
    <dbReference type="InParanoid" id="A8Q982"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="270"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="575" mass="64631" checksum="8A0783559C1DCDB8" modified="2008-01-15" version="1">MASEETKQVNVPGDVAPAVPGNASVQQASASEASTQGKEELNPDGTPLSDKQRRKRAEKAEKERVKAEKAARLAAEQEARQAAEVDYAADNYGVLPMNQSQEKTNEQLMAIEDIHPDKDGQPITMLARLQTSRSPSAKLVFLTFRQTMHCVQATLAVTPEKVSRQMTKWAASITPESIVRVEGTITKVPKPVESPSVTVKEAEIKISRIFVAVPVTWEGQIPFYVDDATRSDAEIEASQDTPRPLPPIALDTRLDNRVLDLRTTTNQAIFRLNHGICRLFREFLENNGFIEIHTPKLQGAATESGASVFKVDYFKGNAFLAQSPQLAKQMAIAADFGRVYEIGPVFRAEDSNTNRHMTEFTGLDLEMAFQEHYHEVVDLLNQLFMYIFSELPKRYSAEIATVRRQYPADDFLVPEAPVRLDFREAIQMLRDAGYEVNDLDDLSTETERALGKIVRDKYKTDFYAVDKFPLDIRPFYTMPDANDKRYSNSYDFFMRGQEILSGAQRVHDAKFLEERLAQAQIPVSAMKHYVDAFRLGAPPHAGGGIGLERVLMLYLGLGNIRRVSLFPRDPKRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9H1</accession>
    <name>A8Q9H1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729445.1">
        <property type="nucleotide sequence ID" value="XM_001729393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9H1"/>
    <dbReference type="FunCoup" id="A8Q9H1">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9H1"/>
    <dbReference type="GeneID" id="5853752"/>
    <dbReference type="KEGG" id="mgl:MGL_3480"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3480"/>
    <dbReference type="InParanoid" id="A8Q9H1"/>
    <dbReference type="OMA" id="TQELLWT"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="553"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="485"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="717"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1232" mass="135706" checksum="11D01EAF38E782CF" modified="2008-01-15" version="1">MTEWTQQAHVFADHAVSGVLGAVTSLHFDPFAELLWAGSESGQLSSHTNTLPTLPRYTSLAAHGTPTHRQSVRGILSDDKYVMSVSERSVCASQRNGLNRWMLDLAKEAPGFLLAGVCASPQSSSSDIIVGGATTSAAPASPEPNPGDALLAVHANSGRIVRRAPSNAAVTQVRKGQKYVCVGTEHGTIQLHDPRSLRSEHKLSAHHGGLIDIQTDGHMIYSIGWTLRQGRRVAEPFIKAHDLRSMHTLVPIPLTVPGGPAHLAVHPKKSSILAVATPQSHFQLVDIQQPGLGQFYTLGSSAYITALTFSSSADALAFGESDGTVRLWTSNHTHPHPPASVRFNAYTTAPVTGPDYAPPPPVIEWSDDTPLSCIGMPHYTTPLLSRIEYDSLWTDASPLFTMHKHVNEHALEHARHVQGVTFARVPLHLRGTRNRLVPSDHVLSRFDRHGKLTPAARTQMMQGRRSGLARRVDVPMAGLFSDLSTVAAPEPPHSDGSSQLDVQSDARSGRHLRTPGSDHADSMPHDFRYLTIQYSRFGVEDFDFASYNQTPYSGLETNISAAYANSYFQALHYTKPFRAFAKRHIMMPCTADDCLLCEAGFLFRMLEDARGTNCQASNVLRVLTRTPQVAVLGLLDDQVANMSYAHMVQTLNGFFLDQASQRALRTGASMSLSSTMFTLCANPCAWSMMTYSTCGECGHTTVHPHLSHVVDLLYPPGRPSRLHNSGGGTGTGTGTSTSPSTSTIGGMNIGGIPSTTTYPASGHASTVAPGGTHDFASLVSASILRETLSKTPCRQCRSPFSHHRSWRAMASTDALPSVLCINASALHAEQLTHWAEPTRSGRTFVPPRLVMYVDKMGLVHVQSEWEDELLESRSQDDKEALRSHAACYMLRAMVIQAQGRFDAPHLCTLVRSPNDDEPNAWYLFNDFLVRPIDAEDALRFGETWKVPAILMWERTDAAAQSHAAHLAELGSHLQLDTSLLLHDVHMSQHRDASLCRHRVLDKTELPQPGTLVAIDAEFVALAHEELDVFSDGTRTLLQPSRLALARVSVLRGEGPRQGEPFLDDHIHTTERVVDYLTQFSGIHADDLDPARTRKTLVSHKTAYKKLRMLTDLGCRFIGHGLAKDFRIINIYVPPHQVIDTVQLYHSAAHPRNLSLRFLSWFLLKRDIQQGLKIRTESAEQSHEGHDSIEDALAALQLYQKYEEFVRDGRLEDMLEDLYEIGPRVNWRPPEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9L8</accession>
    <name>A8Q9L8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729469.1">
        <property type="nucleotide sequence ID" value="XM_001729417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9L8"/>
    <dbReference type="FunCoup" id="A8Q9L8">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9L8"/>
    <dbReference type="GeneID" id="5853776"/>
    <dbReference type="KEGG" id="mgl:MGL_3504"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3504"/>
    <dbReference type="InParanoid" id="A8Q9L8"/>
    <dbReference type="OMA" id="CWVEGII"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="360" mass="39626" checksum="362F21E9E2C1E012" modified="2008-01-15" version="1">MAEETPKCRGIVPDNDDHMGTRIGALFVILVTSALFTIFPIITKRVTFFQIPGPIYDFAKYFGSGVIIATAFVHLLEPATDELGQECLIESFQKYPMAYAFALISMMLMFVSEFFAYRFGSQILERKGLGGLAHNHQQHAMVPDAAHSEHSIPSNELQHQAHRDEEVFLSADKADLESGEGDSDLFIIQKQTSNVAEIVGVLVLELGVVFHSVIIGLTLATTEWDGDDDKFYILFPVIVFHQLFEGLGLGSRLAFMPQTFSTTFLCVLGLLYALCTPVGMAIGLGIRNTYSPDTPTYYYVSGVFDSVSAGILIYTGLVELLAHDFIFNKDMHTAPTWKVLLNVSEVCAGVGVMALLGLWA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9M0</accession>
    <name>ARGJ_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="1">GAT</shortName>
                <ecNumber evidence="1">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Ornithine acetyltransferase</fullName>
                <shortName evidence="1">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="1">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">N-acetylglutamate synthase</fullName>
                <shortName evidence="1">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="1">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name type="ORF">MGL_3505</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This protein may be expected to contain an N-terminal transit peptide but none has been predicted.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="1"/>
    <dbReference type="EC" id="2.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729470.1">
        <property type="nucleotide sequence ID" value="XM_001729418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9M0"/>
    <dbReference type="SMR" id="A8Q9M0"/>
    <dbReference type="FunCoup" id="A8Q9M0">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9M0"/>
    <dbReference type="MEROPS" id="T05.001"/>
    <dbReference type="GeneID" id="5853777"/>
    <dbReference type="KEGG" id="mgl:MGL_3505"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3505"/>
    <dbReference type="InParanoid" id="A8Q9M0"/>
    <dbReference type="OMA" id="WGRIVMA"/>
    <dbReference type="OrthoDB" id="2017946at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000006">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000398064" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000398065" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="1">
        <location>
            <begin position="267"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="1">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="510" mass="55171" checksum="6F442693842D45C7" modified="2008-01-15" version="1" precursor="true">MWYRTFRTLGYTICRPYATCATKAERFVKTIDPSTLPRGYLVSSTYAGIKNAIRPVTSTNEPSAATTNVPHPQEAPKPDVALIVSSVPAAIAGTFTTNVFKAAPVVHATTALKAAGPNARVRAILTNSGCANAVTGQQGLEDTQTLVNRVQALLSPRNQNAIPTYEQDARSSSTDVLMMSTGVIGVRLPVAHIQRCLEHLAAPSILQSHPDAWLEAARAYMTTDTFPKIRTRQFILGNRRCSIVGIDKGAGMIHPRMTRSGGQLHATLLGVFATDAPISSATLQRCLDEAVRVSFNCISVDGDMSTNDTILALANGQAPFVDLDCTDTPNEWTETEHPDMVNKFAEELKSLCIEMSHLIVRDGEGAEKFVQVHVRNAGTYEQAHAIASSISTSALVKCAMHGEDANWGRILCSAGYASLPASTPAWTLDPSKVNVTFLPPPHQPDDLAPLPTLVNGVPQAVNETQAKKLLSYEDIYVDVDLQGGSWGSQGRSEATYWTCDFSKEYITVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9R1</accession>
    <name>A8Q9R1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-isomer specific 2-hydroxyacid dehydrogenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729506.1">
        <property type="nucleotide sequence ID" value="XM_001729454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9R1"/>
    <dbReference type="STRING" id="425265.A8Q9R1"/>
    <dbReference type="GeneID" id="5853813"/>
    <dbReference type="KEGG" id="mgl:MGL_3541"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3541"/>
    <dbReference type="InParanoid" id="A8Q9R1"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="2">
        <location>
            <begin position="30"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="246" mass="27693" checksum="D949AA3B53E2B7F2" modified="2008-01-15" version="1">MPEDILSRYCDAGKIELRLWKPEPGDHSKTASREWIMEHVPGATALLCIPMNKVDEAVMERAGASLKVISTMSVGYEHIDCEAAKKRGIRIGYTPDVLSGAVADLALLLSLNLMRNVIEGYFTVKDGVWASNPWSPLSFCGPALEGKTVGFLGFGSISQTLVRKLMPFRPAKILYQTARPRPFDMHEDYFRHIAKDDVLQCYFKCHGRLPVPVENEPDTKRFATHCDVILYVLWSEFINYAVLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA89</accession>
    <name>A8QA89_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_3648</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729181.1">
        <property type="nucleotide sequence ID" value="XM_001729129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA89"/>
    <dbReference type="FunCoup" id="A8QA89">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA89"/>
    <dbReference type="GeneID" id="5853487"/>
    <dbReference type="KEGG" id="mgl:MGL_3648"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3648"/>
    <dbReference type="InParanoid" id="A8QA89"/>
    <dbReference type="OMA" id="AWDFIQV"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725531" description="Aminopeptidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="15">
        <location>
            <begin position="51"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="13">
        <location>
            <begin position="296"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="14">
        <location>
            <begin position="592"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP41967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="941" mass="105905" checksum="E526E2DA5892D8BB" modified="2008-01-15" version="1">MWAPSSVATAFLLAWKALVHQRETHVPATLLPSVKIPSSSQSVHLPDTARPTHYDLSIMSDLQDLEFAGGVNITLDILKSTSILEFHAGRNLQLGRVRVQTQDGDMYTVTPTIHHDRERAMVKLPKKLGENERVFLSTGFRAAIDRSLRGFYYSTWAHEGQMGRYALTQFEPTSARRAYPGWDEPAYKANFTFRMLHRVNTTALANMPSAYERSVDKEEVRQLLQTRSSGLSLHQYNLDEWLLTEFETTPKMATYLVAWANGAFLHVSNTTISPLTGRVIPLRMYTTPDLIHQAAFSTEAMAKILPEYEKVFDIAYPLPKLDALVAADFDFGAMENWGLITGRSSIFMHDESMGLRGMKNTAGVMSHEIAHMWFGDIATIAWWESLWLNEAFATLMGEVIVLDRVFPAWKSASEFVVMHWMRALQLDAKRSSHQIEIPLQSERVEDEITQVFDDISYSKGASVLRMLSHMLGKDVFLRGVSLYLKKHLYGSTVTADLWDGISQAAGIDVNTIMSNWILQQGFPVISATEKGDSIYVEQHRFLQTGDPTPEEDSTLWHVPLGLKTKKYVDSKSMLRGQRSMHIPFERANSSFWKLNADTTGVYRVVYTPEHLARLGEVASLGPSSPLSVEDRVGLIDDAYSLAHAGYSRTSSALTLTHALHGETSSLVLQALALKLEQLSSAWWEQAASVRVGLNQFRADLFGPLARKLSFNVRDDDSTETRELRTTVISAAAAAGDAWTLGEIHRRFTHWQDTGDDSLIHPDVLRTVLSEAVKHGDAQAYKTVLQLYHAPPTPLHRTCALMALGSVQRPDLIARTLSLVFDGDIKTQDYTYIFNALSSNTFSRRALWNETKKHFDELSKRLEGNFSLMGVVKAAISALSSEEDLADIQRFFAHRSTTMYHMSLAQGLESVLSQARWIQRDAEDVQQWLFQHHYLPTLMSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAC9</accession>
    <name>A8QAC9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitin synthase</fullName>
            <ecNumber evidence="3">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_3688</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729221.1">
        <property type="nucleotide sequence ID" value="XM_001729169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAC9"/>
    <dbReference type="STRING" id="425265.A8QAC9"/>
    <dbReference type="GeneID" id="5853527"/>
    <dbReference type="KEGG" id="mgl:MGL_3688"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3688"/>
    <dbReference type="InParanoid" id="A8QAC9"/>
    <dbReference type="OMA" id="KYLVNCM"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="790"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="847"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="14">
        <location>
            <begin position="213"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="957"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1071"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="965"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1072"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1115"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1124" mass="125150" checksum="347299D5FCF35F37" modified="2008-01-15" version="1">MLLHRGRSLSRPERGHPRAPLLNPEGEPDDPFSDGRKPHWWRMWWHYLAIVATFWAPPPLLNLVGLHSAPVRQAWREKVTLVLFACALSAIIAFITVGLQRSLCSNQADNLFMNVKDASGAVGVLGNAYSLSDRPNLGGTDIYSDIKANPGLDYTQYLDTSQYPFPECADVNAAVAKPLHCSNVHGKSIQCSDKLDFKMIESKLHLKKQNKSIGFDWDDVLNNTQKLMAIDGHVLNLNTYFATYPQPIPNDSVDRTIRTYFSMNPRIVDATSVFAHDKQARDALGCIKQRFLAGQVNYKTPGCFVADLILYVSLIVILGLVFARTIMAIWFLLVGSRRLASTPPAPGKFSATGMRRPRPKSHVILPNEATQPNAGGVAPWAKKQVLAHPSTAPDHGINQMSSSSVMIPASMTPEDIGNDPYIVCLVTCYSEGLDGISATLSSISSTEYPTNRKLIFVVADGMITGEGESMSTPDICVSLMCPDLRFGTPTPMQYRSVAAGKKAQNMALVYAGHYLNPSGGEPVPMVVVVKCGMPDEVHAKKAGNRGKRDSQMVLMNFFQHVTYNDPMTPLDYDLFRKVHALMGVTPDFFELVLMVDADTKVHPPCLRYLANAMLNDHRIMGACGETQIQNKLQSWVTAIQVFEYFISHHQVKSFEAVFGGVTCLPGCFSMYRIKARKPGYEDWIPVIVKPDITREYSQSIVTTLHQKNLLLLGEDRFLSTLLLRTFPHRRMVFVPHAVCHTVVPHTLRMLMSQRRRWINSTVHNLMELVLVRDLCGTFCFSMQFVVLMDLIGTLVLPVAISLTYYLIVKSAMNPPKDFTSAIPLTMLLAVLFLPGFVITLVRFQPVFIIWLIIYLIFLPVWNFLLPAYSFWHFDDFSWGETRRVEGETKSAAHDADEEGYQAALNVPMRLWTEWESSRIRKQEREARRREEFERQYGGGFYNDGALDAPELSSRALIGKAPPAPRSSSFDLSNSPRSNAVSEDDRWGDQIGAYNENDALPELVHPARPVSMLASHGDGVVEGNDLESMLQGGWDDNVSSLSLKPRGQFMPVLNQSSTSLADERDPLAGLAASRSSVDMNTTFPSIPSFSESLRPFDTPPAASSAVEERRSHARSRSTGVRSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAD1</accession>
    <name>A8QAD1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729223.1">
        <property type="nucleotide sequence ID" value="XM_001729171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAD1"/>
    <dbReference type="FunCoup" id="A8QAD1">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="GeneID" id="5853529"/>
    <dbReference type="KEGG" id="mgl:MGL_3690"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3690"/>
    <dbReference type="InParanoid" id="A8QAD1"/>
    <dbReference type="OMA" id="FWCKALI"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="45013" checksum="55A194691B25A93B" modified="2008-01-15" version="1">MLPSTKEYAIGAVLILLVDVLWTGSNYISNTVLTHGYEKPFAMTYLCTASFTLYLIPFFVLIRQGSGREQAETWWSKLGFYLPHMSNAIPTRAGRPSYTAETRRPAIRLRPSSIDGRRPATDLPVSPRRKSVSRLPETQALIGQRDEEVPSQGENSSLSHAEALVHASELPPLSIRETAVLSMEFAVIWFVANWSFVAALAYTSVASGTTLGSTSGFFTLVLGSVLGIDRFSLCKFAAVALSFLGVALVTWADQDTSHMPQAPTKPLLGDAFALASALCYAGYVTLLKVRIGSEDRISMPLFLGCVGAFNLVAFWPVGLLLHVTGMEPISWPHDSLTTLGIVFNMCITVVSDFAYLAAMLKSSPLLTTIGLSLTIPMAVCGDAIRQAMALSLQSICGSILVLTSFAQIAWDENRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAM9</accession>
    <name>A8QAM9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729000.1">
        <property type="nucleotide sequence ID" value="XM_001728948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAM9"/>
    <dbReference type="FunCoup" id="A8QAM9">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAM9"/>
    <dbReference type="GeneID" id="5853307"/>
    <dbReference type="KEGG" id="mgl:MGL_3788"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3788"/>
    <dbReference type="InParanoid" id="A8QAM9"/>
    <dbReference type="OMA" id="PRDMHAK"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="564" mass="63212" checksum="D5EC50F391E6141B" modified="2008-01-15" version="1">MLLYDVPKLAATSRPSWQVAAAIMLSVRMAVACFMMVSDCDEVYNYWEPVHLLTQTHRKDTAFETWEYVPQYAIRSWAYAAMHAIVPYLVTRMSSLPPYAAFYALRFALAVLSSVSDALLYEQVARYVHVRVARYLLVFLTVCAGMLSASTALLPSSFVMYTTSVAMAFAMQPASTQAWRRTFYTTAVFAFGALAGWPYAIILAAPYVYEELCLCGSDPSCEHTRRLARWLRAVMYASLLAAPIILIDTLAYGRVTVAPLNTILYNVASRARGISPELYGVEPPSYYVVALALAFSMAAPLALAALPMIAITAVRYPMRFRPMTSVTTTSTKTESASPAASAHNSHGSQRAVLLALRVLPLYLWLGLLMTQPHKEERFLYPAYPLVCMNAAVTLYLVRACMEQAYLSITRSPYRASRTMLFSAVTVMPLVVTAVLGTLRIMALIEYYRAPLQIGHAVSQIQGEHTLCYAKEWHRFPSHFFVPRDMQVAFVESDFRGILPHHFHKAAPTRQPGPHVSSLLPRTPFESKLLHALEYATPVLWPWAKYTRTVPASVNERNQHEPDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAR9</accession>
    <name>A8QAR9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3818</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729030.1">
        <property type="nucleotide sequence ID" value="XM_001728978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAR9"/>
    <dbReference type="FunCoup" id="A8QAR9">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAR9"/>
    <dbReference type="GeneID" id="5853337"/>
    <dbReference type="KEGG" id="mgl:MGL_3818"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3818"/>
    <dbReference type="InParanoid" id="A8QAR9"/>
    <dbReference type="OMA" id="SGCGKWE"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122004" description="Calnexin" evidence="10">
        <location>
            <begin position="26"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="233"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="513"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="563" mass="61752" checksum="F74DA6B014A4FFFC" modified="2008-01-15" version="1">MKSFSGAVSTSALALLALQASGVSADSAKSFVPSNIRGLFVEQFTPDWESRWTPSQASKFQRGAEEFKYDGVWSVEEASMFPGIPGDLALTMKSKAKQHAISTLLDKPIVFDGTKPLVVQYEVKMQNGLSCGGAYVKLLSSSESDLDPKQFADTTPYSIMFGPDRCGPDSKLHFIFRHKNPVSGNVEEKHLKVPPHAKVSKVSTLYTLIVNPDNTFDIQVNEESVLKGNLLEDFSPAVNPPKEIDDPNDSKPEDWVDESQIPDPEAVKPEDWDEDAPAMIADPAAKKPIDWLDEEPLMVPDPKATKPEEWDDEEDGEWIAPPVPNPKCDDVSGCGTWTAPMVANPAYKGKWTPPLIPNPAYKGEWAPRKIENPEYFEDKQPNKFLPIGGIGFELWTMDDDIQFDNIYISNDPKEAAKFADETFRVKLPLEQNREQETNDKDDETVKPPAAKSSLEHFANQIRRRTNVLVERLSTEQDKLRVLQQSSDIVGFYAAVVAVLLGLVGLFASMLGGSSTAPPAKQQPSTKKDEPKSAASTAVKGASSSVQDASANVTKRAAAATGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAY8</accession>
    <name>A8QAY8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="6 13">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_3855</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="6 13"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729067.1">
        <property type="nucleotide sequence ID" value="XM_001729015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAY8"/>
    <dbReference type="STRING" id="425265.A8QAY8"/>
    <dbReference type="GeneID" id="5853374"/>
    <dbReference type="KEGG" id="mgl:MGL_3855"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3855"/>
    <dbReference type="InParanoid" id="A8QAY8"/>
    <dbReference type="OMA" id="RNVKGCW"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rhodanese" evidence="16">
        <location>
            <begin position="211"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP41853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="758" mass="82572" checksum="2612965DA92C84E9" modified="2008-01-15" version="1">MNYRHLVIDESRNYADELWSKDQQRALEAIANAIISPLTPKEKESFLNTLPSDLSAEDKARANEYADLSFSDLPNGVNLIAMHVHETVSFTLRSLITLLLKSLATRAGCLALIGRVGPVWDVDQDAIVTTLLAWRTSPIQVLRLGQFGLIGLTMMVFYRHFEKATEAIGYPTGPTDDWKTPPGFEEQTAIPHYNFQFLNDNLPLSPTSEPIDLETDVVVVGSGCGGGVVAAYLAERGLKVVVVDKGLYVRPEEMPLTQSFGFDQMFERLGFVPSSTMSIGVLAGSGFGGGSTINWGATLTPRYFLRQAWSKKYGMPYFESALFTQDLDACAHRMGTTDNITHNRANTLLMLGARRAGQPVSAVPQNNGNLPHYCGKCTFGCPSGHKHGTLMTYLRDAAEHGAQFLTHCDVERVLMEDGKATGVMGHVKGQSVRIHGKQGVVISAGSVNTPAILLRTPELKKNKQIGEHLHLHPVAFVHGFYDIPVYPWEGGSLTTVSNAAELVDPHGWGAKIEVMASAPSLFCAILPFQNSAQHKKLASRYRYSYTAIVLVRDRDGGRVKLDKYGRALMDYNLSKFDQKSMLEGVKRATEIHMNAGASAIAVTQFDVPLYECPKNKLPSSVPEKLLPGSYPFDSLPPQGDVMHPSFVEFQKQIERAGFSTLRCTLGSAHQMGSCRMGADPTTSACDPRGRLRGASRLWVADGSVLPEASGVNPMLTILGTSRGIARNIAEELGVARSDDLASTTSTSIPAPSPPRAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB04</accession>
    <name>A8QB04_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729075.1">
        <property type="nucleotide sequence ID" value="XM_001729023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB04"/>
    <dbReference type="STRING" id="425265.A8QB04"/>
    <dbReference type="GeneID" id="5853382"/>
    <dbReference type="KEGG" id="mgl:MGL_3863"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3863"/>
    <dbReference type="InParanoid" id="A8QB04"/>
    <dbReference type="OMA" id="APENEPC"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="305" mass="32733" checksum="B87EBF4D0E6A463F" modified="2008-01-15" version="1">MSPMAQATLSTGSPVYAIDFIDPKHFVYAGGGGAGRTGVPNVIKATEIQLPDGIPSLHSCGEIMLNSNEDAPMCLSVNPSKTLQSHLVCGINAPADEMKQGKNPHVRVFEFSVHEHPAARAEAQMGQASSSISLSPITAIPSLGITDPEHYQKTAQFSPDGKLFTVASTDGRLQLHRYPSMAPVFSSSIGVISLNEEIYDTDFSHDGRQLAVTTLSRIVIFSTTPQTIEGETPTFAPRILQVIEKPVVGSGTGATFRMGNESTWPLLGRWLVRHVCHVASCSHVASAPENEPCSWLPTYMHGILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB81</accession>
    <name>A8QB81_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728895.1">
        <property type="nucleotide sequence ID" value="XM_001728843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB81"/>
    <dbReference type="FunCoup" id="A8QB81">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QB81"/>
    <dbReference type="GeneID" id="5853197"/>
    <dbReference type="KEGG" id="mgl:MGL_3889"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3889"/>
    <dbReference type="InParanoid" id="A8QB81"/>
    <dbReference type="OMA" id="ERENDMQ"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="715"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="548"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="84534" checksum="B159AE7122FFE132" modified="2008-01-15" version="1">MISNDAFLHKQGPLARVWIAAHWERKLSKSQFLQTPIPSNVDMIVEEDEGHVALRLSGQLLLGFARIYSRKAKYLQDDCSDALLRIKVAFRGTAVIDLSHEQLHVSRTALTLPDVYSPIDLLMPEPSLSDWGITTVPSAKSSLPSRHIARHSDITLPDTQFTVPEDNDMPIHTDEAQLETSLHEFDLGLVDTNTNNGAQFFTAPPTKRTRREPRRDTTRHTLPDADFDDSFASVGVARRAPQNEGSLVSEAEAAASRHVHELVGDLDLSASDMPLDPLSHISPVPLTNETFDDGGVGINPISAADISTDSIGFDVSELPVEPPAAATPPPARQRWDHLPSAPALPTPPLLPRPRASSTTPARHLTLDDVAHAHLTPHTAAKLRTAAEHRALGAPSTKAPRKRPIQDDVTELFPARARSLQARAASVAKTMNKQPHEQHCLPDSRIQLAILASHARGAKPALPRSLGMSWGAVLQGPLIDTIMPLTWDTRRAWLATQTAERENDMQHWLRAIHEQACELSADDEFPMEVGRRAPELPAWLAHEAEPHHQPDFMDIDSSMDLGTGRQDMSKRNGMDGFDISDVTDAPLDTEMPPAPDLPDLPPIDEPQEPTNLSSPTSMRQADDHYMSSPVPLRRSSRHQHRKAVNSDEANTRLPPLSRMSTPDLDDTDEVEVNVPTTNPIAAFDMRVRETSVDGYNIRTKRAAHVLRTTMDGDSHVSFDALASKGSRRAAAGFFFEMLVLGTHNCVRLEQDTPYGNMDIHAKEALWGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC40</accession>
    <name>A8QC40_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728978.1">
        <property type="nucleotide sequence ID" value="XM_001728926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC40"/>
    <dbReference type="GeneID" id="5853284"/>
    <dbReference type="KEGG" id="mgl:MGL_3972"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3972"/>
    <dbReference type="InParanoid" id="A8QC40"/>
    <dbReference type="OMA" id="SGYPHDF"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725239" evidence="3">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="132" mass="13984" checksum="01B5949BAB862E8B" modified="2008-01-15" version="1">MKCVVLLSLAFAGISLATPVYRRSGVAHCGVNTGGDINVSSAAEQARNAPTDDHGRSYPHQFKNYEGLPMSNACSGASMMLELPVFADGHAYNIAHGEKPGAARVIYSADDHSLCAIVAHDSNDSNFHLCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCI6</accession>
    <name>A8QCI6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728846.1">
        <property type="nucleotide sequence ID" value="XM_001728794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCI6"/>
    <dbReference type="FunCoup" id="A8QCI6">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCI6"/>
    <dbReference type="GeneID" id="5853152"/>
    <dbReference type="KEGG" id="mgl:MGL_4013"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4013"/>
    <dbReference type="InParanoid" id="A8QCI6"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="56"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="266" mass="29304" checksum="E0F9ECA193D70D52" modified="2008-01-15" version="1">MPATDESAPSASKDKQQSGPLVKADAITQSSEKLDRVRGARLKRPSYSLLQRPETLLTYAQVLFNASILFVFLYLLFNVVWTIQHDVAQKVREYELDYLGEISTCNVRYTSNRCGTELQAPVLAEACDAWKRCASRDPTVVGRARVTAETFAEILNGFVDVVSWKTMLFSLLTLSIVVGATNSTLSFFRLNASQTREANNSHATLPSAGPATYAGRTLHSQAYGLPSLEYDGPVPPPRWRASRAKELKSIPYSMSDEDDGAVEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD19</accession>
    <name>A8QD19_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1977 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_4087</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728752.1">
        <property type="nucleotide sequence ID" value="XM_001728700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD19"/>
    <dbReference type="FunCoup" id="A8QD19">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD19"/>
    <dbReference type="GeneID" id="5853065"/>
    <dbReference type="KEGG" id="mgl:MGL_4087"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4087"/>
    <dbReference type="InParanoid" id="A8QD19"/>
    <dbReference type="OMA" id="CESAQEY"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1977" evidence="7">
        <location>
            <begin position="128"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="261" mass="29603" checksum="49991F973F55C708" modified="2008-01-15" version="1">MYDRFGGDPESRFGNASATGSAHPFAQFQGGGARMRPGMGPDIDPEDLFNMFFGGGMGGGPFGSTPVFTFGGPGMRTHYYRPGAGARARQAGQQSAQSNQTAMWFQLLPLLILLLFTILSYLPNLFMVSDPDFRWRPTSLHRAQRTTFDRGVSYYVDPVAFAKHPYVTATTTSTRQGGNVQRFSREKNSPELRAFERRVEESWMKELYRQCESAQEYKNRRIIDAQGFFGFGADKEKVQKIRSEVYESCEQLERLYGIRFR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-24" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD49</accession>
    <name>RS3A_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">40S ribosomal protein S1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RPS1</name>
        <name type="ORF">MGL_4117</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728782.1">
        <property type="nucleotide sequence ID" value="XM_001728730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD49"/>
    <dbReference type="SMR" id="A8QD49"/>
    <dbReference type="FunCoup" id="A8QD49">
        <property type="interactions" value="438"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD49"/>
    <dbReference type="GeneID" id="5853045"/>
    <dbReference type="KEGG" id="mgl:MGL_4117"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4117"/>
    <dbReference type="InParanoid" id="A8QD49"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000389385" description="Small ribosomal subunit protein eS1">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="260" mass="29715" checksum="8A3937CA427B7887" modified="2008-01-15" version="1">MAVGKNKKLSKGKGNKKRAVDPFTRKEWYDIKAPVFFENRNVGKTIVNRSQGLKNASDALKGRILEQSLADLNKDDEQAYRKFQLRVDEVQGRNCLTNFYGMSFTSDKLRSLVRKWQSLIEAHQDIRTTDGYLLRVFAIGFTRRRANQVKKTTYAKSSQIHAIRKKMFEVIQRESSSCDLREFVAKLIPEVMGREIEKSTQGIYPLKDVFIHKVKVLKRPKFDVNKLYELHGGASVVGAEDVGTKIKSGEFKEPVPQASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD63</accession>
    <name>A8QD63_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_4131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728796.1">
        <property type="nucleotide sequence ID" value="XM_001728744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD63"/>
    <dbReference type="GeneID" id="5853036"/>
    <dbReference type="KEGG" id="mgl:MGL_4131"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4131"/>
    <dbReference type="InParanoid" id="A8QD63"/>
    <dbReference type="OMA" id="CHTHAIH"/>
    <dbReference type="OrthoDB" id="3339789at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="224" mass="25602" checksum="CAC88D7F7C35A551" modified="2008-01-15" version="1">MMYHRAVALVPLASRTPCHTHAIHTTACVSVSRRTRRQVKRQKDEDLRHAISLYHITPAFYRTDVAGDKDQELRDEVAESILGPFLNHRSGRSFVQCSNTHELMHHQREAWHTARRDTLSEMDTYENAGLPSSFLSKMSTSLPPRHRQAHDSDGLRAHFVKPPSAYPTRRARDTAGHGDLYAQDELSLRSAQVRDALYGTVAGELPGLEIVREYERDWDAHEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDC9</accession>
    <name>A8QDC9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728707.1">
        <property type="nucleotide sequence ID" value="XM_001728655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDC9"/>
    <dbReference type="STRING" id="425265.A8QDC9"/>
    <dbReference type="GeneID" id="5853021"/>
    <dbReference type="KEGG" id="mgl:MGL_4186"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4186"/>
    <dbReference type="InParanoid" id="A8QDC9"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="415" mass="46060" checksum="3576C2143E9FA9BF" modified="2008-01-15" version="1">MMAQTRARTRTLDRILAPTRIRMPIQARTLTPSLDRVLILAQVPAPTRTRMPIQARTLTPSLDRVLILAQVLAPTRTRMPIQARTLTPSLDRVLILAQVLAPTRIRMPIQARTLALSLDRVLTLAQVLAPTRIRMPIQARTLALSLDRVLILAQVLAPTRIRMPTQARTLAPSLDRVLILAQVLAPTRTRMPIQARTLTPSLDRVLTLAQVLAPTRTRMPTQARTLTPTLDRALILARVLAPTRTRMPTQARTLTPTLDRARTLALVLAPTRIRMPTQAPAQTLTQILTQVLDRTRTRIQALVQTPILIRIRNLALVQAALARTLALARTRIQIPTPTRVTVITMMMTTSSVMMMTVMTAASCRHYCDHSHRLASLKRVKGSSSSLSTTNTQEKSSSKPSSSTKSSKHHHHSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDF2</accession>
    <name>A8QDF2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728719.1">
        <property type="nucleotide sequence ID" value="XM_001728667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDF2"/>
    <dbReference type="FunCoup" id="A8QDF2">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDF2"/>
    <dbReference type="GeneID" id="5853007"/>
    <dbReference type="KEGG" id="mgl:MGL_4198"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4198"/>
    <dbReference type="InParanoid" id="A8QDF2"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725583" description="Plastocyanin-like domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="31"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="161"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30854" checksum="BEDCED1A2EAB6580" modified="2008-01-15" version="1">MWAASALVLLLATTAFGAEIGKQWSVGWVDNVNPDGKFPRRAIGINGKFPADPLIVNSDDFVHINFTNKFGDGRPSTLHGHGLFFTNVNYYDGAASVTQCPVPDGYSFYQEILNSPKSGEKSPKQWGTYWLHGHYKGQYIDGLRTPFIIHRSEGEAYDYDDDYTVVMADWYHHQHGYIMRHDYMTNGGDYQTPDSGLLYFAHTKANHTAKTLKGINENATLPFEPGKTYRLRLINMSAASVFDFWLEGHDMEVIEVDGVDVERYPIESVQVAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDK5</accession>
    <name>A8QDK5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000022">
        <property type="protein sequence ID" value="EDP41442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728656.1">
        <property type="nucleotide sequence ID" value="XM_001728604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDK5"/>
    <dbReference type="STRING" id="425265.A8QDK5"/>
    <dbReference type="GeneID" id="5852955"/>
    <dbReference type="KEGG" id="mgl:MGL_4217"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4217"/>
    <dbReference type="InParanoid" id="A8QDK5"/>
    <dbReference type="OrthoDB" id="2556125at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="764" mass="83674" checksum="CF1BD82090EF2C89" modified="2008-01-15" version="1">MGASSGLGVAPERESGHGEEVESEPLPQPEPERDLSSSYGNGSDEGARLKQNFDKPRAFVPDTVIRDIDLGTELEHEHESHPEVQLQSASMPILEPQHPFDERLEAPRESYDRSDTSSEPDRSMRGHGSLMHRSLSLQGPLNPSLSHMSNGQTNLKISPSKEPALYETVTVKNENTSAETPLYVGPVKKEAMSEHPEKQLYESDADFDDDDIQDYALEETLDAMDAWENELRIDTGKMAEGSNRDSSPSGHITTETSPSVNVEAIDTVSPERSREITPSEHTRDVIDQTHSPISNEISLDGARARRSLSPEKISTGLLSPMASKPSNAATRVSSALPERVALVPVSSVEDDTQQTVETGASRTCIHDHDHEHDNLTVWSLPLQAPAPSTDQDLSLSDLSASLSASSHSRAMMLSRPCPTSCVEISSLDPVAAARAAAILKVHHKYVQEGWLGESESTIASTSENETMSLPAILHAAERALRHRPHVPFVPKSRALGASTPHATYPAPELASHALRPQAQAGHWSEHAWIELDRHMRAHISQDADNLSSAVLSVDVDQVILQFLDAQGLEPDDLHGDWKLTRLYARVPALQARYLRELEQDMTEQMQEKSFQLLSESRKRPHDVSFGPAYVHGAHSTPLSARPSSTKFLAQESSVMSQSNAGADDTDALTEAGPPPKRLRSTVTPASGVVSKLWTWMTGPSQPRTPALFSNHRRRKMSSVSRIPRPVPRTRAPAPRPQLNTARNESRGDKSGAMYPSLDQLDEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR10</accession>
    <name>A8PR10_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0566</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732791.1">
        <property type="nucleotide sequence ID" value="XM_001732739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR10"/>
    <dbReference type="FunCoup" id="A8PR10">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR10"/>
    <dbReference type="GeneID" id="5857097"/>
    <dbReference type="KEGG" id="mgl:MGL_0566"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0566"/>
    <dbReference type="InParanoid" id="A8PR10"/>
    <dbReference type="OMA" id="EPMRPGT"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="10">
        <location>
            <begin position="277"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="393" mass="40629" checksum="1C420A3A9F54AFEB" modified="2008-01-15" version="1">MSSSAPNGGHAPVFIASAVRTPVGCFQGTLKSQTAIDLGTAATKAAIDRAHIKPADIDEAYLGCVLQGNLGQGPARQVVLHAGCPDSTEATTVNKICASGMKALALGAQSIRLGERDVVLVGGMESMSNAPFYIKRGGLLYGDVPAQDAILRDGLTDALHHKPMGLCAEQTAQKYGCTRQEQDAYAIQSYERAAAAWERGAFQQEIVPITIKGKRGESIVQEDEEYRKLLKDKISTLRPAFDAQCGTITAANASSLSDGASALIIASAHAVQKHQLTPIAQVLASADAACAPVDFSTAPSIAIPQALAKAGVSADQVALWEINEAFSVAALANAKILGLDLAKVNTLGGGVSLGHPIGSSGARIVVTLVHALRPGDIGVAGICNVRLHKDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRA3</accession>
    <name>A8PRA3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732231.1">
        <property type="nucleotide sequence ID" value="XM_001732179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRA3"/>
    <dbReference type="STRING" id="425265.A8PRA3"/>
    <dbReference type="GeneID" id="5856542"/>
    <dbReference type="KEGG" id="mgl:MGL_0006"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0006"/>
    <dbReference type="InParanoid" id="A8PRA3"/>
    <dbReference type="OMA" id="VQAFMSH"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10289">
        <property type="entry name" value="GST_C_AaRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="9">
        <location>
            <begin position="213"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42153" checksum="7C9085C156C7F719" modified="2008-01-15" version="1">MAQRSRQLLAEVYTRLISDQASLNALRTSNKPLRTYAHELAALTSKPAAVLGETDDDVKNTEQWLDQVEGISGDLGSLDKKLEPITFLSGNAPTAADYSLFASLYDVVSTMPPATQHAHPSLVRYFSHMSHLSASTNVEPPFKPFEPAYEGFPKIERKAEPKKEKKEKKMKDEGGTAAEASAPTPSKKDKKSKDKATGGSGPGSGVPSDSGPLPSMVDLRVGKIVKVDRHPDADSLYLEQVDFGEADGPRTILSGLVNFVPIEEMRDRWVVGVCNLKPVSMRGIKSFGMILCATAKEGKEGGVQPVAPPAGSELGDRVYVEGYEGMEPLEQMNPKKKVFEAIQPNYQTTDAKECVWFGSLPNGPADEKAPRRLCTSRGICTAPFAGATLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRH5</accession>
    <name>A8PRH5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732279.1">
        <property type="nucleotide sequence ID" value="XM_001732227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRH5"/>
    <dbReference type="STRING" id="425265.A8PRH5"/>
    <dbReference type="GeneID" id="5856585"/>
    <dbReference type="KEGG" id="mgl:MGL_0054"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0054"/>
    <dbReference type="InParanoid" id="A8PRH5"/>
    <dbReference type="OMA" id="WIERWCA"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="409"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="766" mass="86126" checksum="9D64C7E78758489C" modified="2008-01-15" version="1">MLIDVLAPYVKGGVTAGRTSNASMSDATNRVVHALEAFEGPDRPDAFMYNEASVAEVVHAVICGKPTLPDRSVPSVYAEMRVLAGVRGLPERVLSDAHKHVQEALVVAIDPLHAEAQDPGEWLCRMVKLWNELMQRLCMVQDMLRPVVVCADETDFDAACMNMLTRTCRTTQSITVWEQGLYQVAEAARLGVSASQVDLRSLSAPKYLERALEIVRRVGTKVEPVIDEAHSFYRSYALQLYSGRANPPEIAHSMPVIHNWIMREQAWASWLGPDASVVDVVQDVIVRPHQDILSSAWPYLMETSEGTVGHAGPIPNSDSVSAAAELRACYAVFDAACILPRLYEAMREYIQARVCALLQKTSDDVLIEHLITGQRTWHRLWWSCLQANTSMRHAIQDGFEAGLRGQSAHIAELLANYIDAELQKGRGLVDSSMPEACMDDVLFLFRCLHHKDLFEEYYQRAFARRLLLRCSASDDAERAVILRLKHECGPDYTRKLETMLKDMHLSDNLRSAFAEAGGASTPFEFEVDVLTQAHWPPFHDAPLILSSSMQSALLRYETFYHTCHSGRSLHWCHALGSLLVRADLGEAGVKDLVVSTLQAAVLLVFNVRDVQTFSELEQATHMPLHELQRTLQSLACGPARTRILRKIPPGGEVRESDSFMVNEQLSNARRRIKLNQLQQRDSPEERRTSTEHVLMDRDVLLQASAMRVLKAHKLISHADLTTAVIEQVKSRFPVETAELKRAFERLIEKDCMERVDGDRQVYRYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRJ7</accession>
    <name>A8PRJ7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CpG binding protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732293.1">
        <property type="nucleotide sequence ID" value="XM_001732241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRJ7"/>
    <dbReference type="STRING" id="425265.A8PRJ7"/>
    <dbReference type="GeneID" id="5856599"/>
    <dbReference type="KEGG" id="mgl:MGL_0068"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0068"/>
    <dbReference type="InParanoid" id="A8PRJ7"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022056">
        <property type="entry name" value="CpG-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12269">
        <property type="entry name" value="CpG_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CpG binding protein C-terminal" evidence="1">
        <location>
            <begin position="196"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="254" mass="28550" checksum="8C5BC9E828B2E01F" modified="2008-01-15" version="1">MDEIRSRMDAMKPQDTRRIIQPSSIANVDARRGLCVWTPSPPIHTHLPLTDGKADSVWFDQIQSALTNARSEAPQAPPGMSYGEFVRQEATRFDTKELDLAHMKTELKHFERQCTLLHVSLDLLSIRGKLLQIADDRPSAHLSHQSDQTNDAGSNIQESTPTCGFDERLCMDDELLAAWATSAHGRAVLNDEQPWNIEDSSAHICTVAQRDCKRHADWSAMRAAELDMLRDAQTAQLSALSERSHMLRITIERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRJ9</accession>
    <name>A8PRJ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0069</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732294.1">
        <property type="nucleotide sequence ID" value="XM_001732242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRJ9"/>
    <dbReference type="GeneID" id="5856600"/>
    <dbReference type="KEGG" id="mgl:MGL_0069"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0069"/>
    <dbReference type="InParanoid" id="A8PRJ9"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="81" mass="8934" checksum="39CCC672D9DCD3FB" modified="2008-01-15" version="1">MTDAAALVSRAYEYAQDGILALMSCLDCADGYGTVNVNGVSYEVMQLLGEGGFSMVYLVRDRTSGRMYALKKVKLIRKFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRM4</accession>
    <name>A8PRM4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cation efflux protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732310.1">
        <property type="nucleotide sequence ID" value="XM_001732258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRM4"/>
    <dbReference type="FunCoup" id="A8PRM4">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRM4"/>
    <dbReference type="GeneID" id="5856616"/>
    <dbReference type="KEGG" id="mgl:MGL_0085"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0085"/>
    <dbReference type="InParanoid" id="A8PRM4"/>
    <dbReference type="OMA" id="FQDCASW"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="310"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="390"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="58851" checksum="83E3C6CD15D01035" modified="2008-01-15" version="1">MAGLDNQTKIIALLGIDIVFFFIEIISGYAVGSLALVADSFHMLNDIMSLVVALYAVRLVQKGGQSPKYSYGWQRAEILGALFNGVFLMALCFSIFMEALERLIAKPQVSNPHVVVTVGSLGLLSNIVGLCLFHGHGHVHGHNHSHDHGHDHDIENGTSHHHDMEQGHENHHVHKSDRDQHQNGNREGRQHLHGHEHAHGRRTESATERTTRTKNEEAELGQKVRDIVGHPAKARAFVMDKAHSLGYDTASSKHDSEHHRLLSPRTTSSSYGAVNLPSASVSPSRQRRLSHAEASTEEDVRRHRQSIGSGAHTHDNMNMTGVFLHVLGDAIGNVGVIFAGAFILFTEYSWRHYADPVISFIIACIIFHSALPLVKSASFILLQGVPTTVSLDGVRDSVLRIEGVLSVHDLHVWQLNENKIVASLHVMVDCSGEQTTRYMFIADQVRRTLHIWGIHSSTIQPEFVPGGLKEAAELSGVAVQDRFDEHGRLLTPDGHLVREEVASGLNSACLLACDGDECRDAQCCEMPSSGKSSATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS23</accession>
    <name>A8PS23_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0178</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732403.1">
        <property type="nucleotide sequence ID" value="XM_001732351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS23"/>
    <dbReference type="STRING" id="425265.A8PS23"/>
    <dbReference type="GeneID" id="5856709"/>
    <dbReference type="KEGG" id="mgl:MGL_0178"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0178"/>
    <dbReference type="InParanoid" id="A8PS23"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="10">
        <location>
            <begin position="150"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="261" mass="29786" checksum="91DB6D7417EBCD65" modified="2008-01-15" version="1">MTDSEQDLDALRKLAALDDDLNSEDLDNLEEEAENELMEEMKHDESNEISDSGALEQPEDSADESASSDYVFGPLEPENVALILSDLRTHGISECVRRHVLPNPKCIIDILLSLGVMLPRSMLQEAEDEPSLLLPILKMVFIRILRQRQKLVEYNTIEDAVDLIKRCERIVVLCGAGISVSCGIPDFRSKDGIYAILARENRYELDDPSDMFDKETFLRDPNMFYSFAHSIYPANFEPSPSHRFVREIEKRNKLLPRRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS43</accession>
    <name>A8PS43_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732415.1">
        <property type="nucleotide sequence ID" value="XM_001732363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS43"/>
    <dbReference type="FunCoup" id="A8PS43">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS43"/>
    <dbReference type="GeneID" id="5856721"/>
    <dbReference type="KEGG" id="mgl:MGL_0190"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0190"/>
    <dbReference type="InParanoid" id="A8PS43"/>
    <dbReference type="OMA" id="HENTVEE"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP45201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="201" mass="22595" checksum="6CEE8A227DA0EEF7" modified="2008-01-15" version="1">MATNITFHPGNVTYDERSQLLNQKGMTIWFTGLSASGKSTIAVALEQHLLHQKKSAFRLDGDNIRFGLNKDLGFSPKDREENIRRISEVALLFASSTSIAITSFISPYKADRDMARELHKKHNPELPFVEVFVDTSVEECAKRDPKGLYKKAMSGEIKEFTGVSAPYEAPENPEIHIQGDKCSIEESVKHIVDYLLSKGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS75</accession>
    <name>A8PS75_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732432.1">
        <property type="nucleotide sequence ID" value="XM_001732380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS75"/>
    <dbReference type="STRING" id="425265.A8PS75"/>
    <dbReference type="GeneID" id="5856738"/>
    <dbReference type="KEGG" id="mgl:MGL_0207"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0207"/>
    <dbReference type="InParanoid" id="A8PS75"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF62">
        <property type="entry name" value="AT07585P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="397" mass="44447" checksum="E6FD7958DBB1A8E6" modified="2008-01-15" version="1">MPYDRLSEHGDVLHDYHAEVLVRRGVRSWLLERLIKEQQAPIDCGVVDELPRLLVPTEWHENKPSRWKLASDFRLSWYVSMLPCGEASSSALRARHTMEDGHAPEPVRYSSSASAVLRGRTMSQLSTSACILRTKPGRPDAPPSISMSCSDKLMLWSALGIQGALLSRWIEPVFINQIVVSFDPFLCPGLTASECCASCLSAISERLENEVVHRPNVLTSSLMFPHARECVERQVLKETHLSKGTSAWQDIEPVPSAASVLWIRGRPLEKLLGGIKMGASLRRRGNTPLPLSTLSSVCQRAWYMQYLNACKVLSNDDTCSYLAYYDQKHASNNASTVAYSERKNMLLGYSSSSAKLYRFLDMRYSMDDPVLPPSSSAPLSAWIRTPRALQDFRVEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSD9</accession>
    <name>A8PSD9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732465.1">
        <property type="nucleotide sequence ID" value="XM_001732413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSD9"/>
    <dbReference type="FunCoup" id="A8PSD9">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSD9"/>
    <dbReference type="GeneID" id="5856771"/>
    <dbReference type="KEGG" id="mgl:MGL_0240"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0240"/>
    <dbReference type="InParanoid" id="A8PSD9"/>
    <dbReference type="OMA" id="QIVQLTY"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="95"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="571" mass="63706" checksum="C995CC704EC5EBDD" modified="2008-01-15" version="1">MLAGDIPTPASLLMGRAVPATVASATAIPTLLNHSHEPTFSYTPEKSMQDLASEPTSIAPLASDRLLHAQTEDITAQKMASGQSFPLYEGLPERYELVAMLGNGTFSTVYRAYDRKTNTPVAIKVVRVGDKEQNRALNPNIREHDRSTERASILQEVQIMRRLRHENIVQLLDFIDADEYCYLVMEIVNGGELFDQIIKLTYMSEPLARHVICQVAEGIRFMHNECGIVHRDIKPENLLFEHIDTEPSESFQRKPYDEETKIDEGKFVPGVGGGEIGRVKIADFGLSKIVWEHSTKTPCGTVGYAAPEIVRNEQYSLSVDMWALGCVLYTLLCGFPPFYDESIKDLSEKVSNGHYAFLSPWWDDISDGAKDLVAKLLCVDVDARMTISEFFEHPWVKSGSESTNGASALVQQQTRKRMWPLSNMESVDSPLLASLHGNDGYQEGVSTPVSKNHLREAFDVSFAVHRIEEEMRQSKRYRSLQPPTGTGVNSTAHDVASADARYGSLAAKIILDKHNSHAKQKAPSFPTAPSNQDDFRLSMDGATILQRRKHMRKPPNSEFEKPDHMPVCLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSI4</accession>
    <name>A8PSI4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0263</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732488.1">
        <property type="nucleotide sequence ID" value="XM_001732436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSI4"/>
    <dbReference type="FunCoup" id="A8PSI4">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSI4"/>
    <dbReference type="GeneID" id="5856794"/>
    <dbReference type="KEGG" id="mgl:MGL_0263"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0263"/>
    <dbReference type="InParanoid" id="A8PSI4"/>
    <dbReference type="OMA" id="GMVPQVW"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727856" description="Protein-S-isoprenylcysteine O-methyltransferase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="188" mass="21530" checksum="BAEE577456184A4F" modified="2008-01-15" version="1">MYLLVWSCFHLLEFVVTAYWNPIHLQSDSFLLQNGFEYVAAHIFGVLEYMLECACTRPAWKHTQFIQCVGLALILTGQLLRSFAMIHASTNFSHALAHTKREDHTLVTTGVYALARHPSYAGFFWWALGTQIFLGNPVATVGFAVLLTRFFAHRIQIEEHTLRAFFGEAYRAYEVRVPRGVPLVGWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT02</accession>
    <name>A8PT02_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732570.1">
        <property type="nucleotide sequence ID" value="XM_001732518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT02"/>
    <dbReference type="STRING" id="425265.A8PT02"/>
    <dbReference type="GeneID" id="5856876"/>
    <dbReference type="KEGG" id="mgl:MGL_0345"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0345"/>
    <dbReference type="InParanoid" id="A8PT02"/>
    <dbReference type="OMA" id="DTERIMQ"/>
    <dbReference type="OrthoDB" id="1748564at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="184"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="555"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="652"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="247"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="921" mass="100451" checksum="56D608C6601BA457" modified="2008-01-15" version="1">MARGNKDKSASKGAADKSKISEAQGTEKDSRAAKSSETTSELEPAVPEANETKDAGVNAVAQNDGQSLPNDQKRTPEKSIVSSNGEKGLDAGKPALDTTASTASGIAQLSSKESEARKTVETISDTAKENSGKTEPTEETIVDSHTAAQVDALASMSPEEREAELRSQVTSLNTKLVSAINRMSDLEDELSVTQNTLAVKSSRLDELSKERDQYISALDTGLLVEKSHVTSEMQRMMERVVDETAQRGKAENDRTRIEAELEELSASLFNEANKMVAVERLQRTRVEERSRELEATLHDTERIMADHQDMLKSLQSEIEVLRRQPITPTFLSQAPSELAKPTLHIFVNVPPYQEFLAFLAYLRSLQMQLEPYFMMSRNGVDWTTAPPSSPAPFMGSVMASSSTNSLSATRHRDYPHLPMSAEQLVHVSSQTSLPFIRRMLEEDTDPCLRLAQAPGLNWLARRQASAAVLDGDVMIEPIFAGGIVPDERAIRDEYGALPPVPCAICSTPLLNVTPVMDGTSSSSTSDANPSRSNSISWSNSSGRRGFPSLFQTLRRSHTERSWTPPIEPEGKDKEQSDSSSRGSASWHADSLPIPTHYFRLSDQATNRYLLCAHNCLYRLRAICAVWAFVRTLERSIVLEGKYEPDMVGQIPADRSRASSSSASRSSCVVNAPNEASHSETQPLAQPTARRGVPAEVPPDMDPDDYETHQNMDGAKEASEAGEASEAKKKDDSEASKLLESSDTVNATGIRPSKKVEEVSETSKDERGTPESHAPPASEAGTMTAPEPIMDTNSNGTDVQPSEDRIDPDNAVSSDSKPKPRNESQVSDKSGESNGSGKGERSKPDDGELKPPPPPKILSRTTSSASPAPIFPTATLSRVSFQADPDRSGLSWEDSLWMEVLRYKELLWKVRVGVDLESLDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT29</accession>
    <name>A8PT29_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0358</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732583.1">
        <property type="nucleotide sequence ID" value="XM_001732531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT29"/>
    <dbReference type="FunCoup" id="A8PT29">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT29"/>
    <dbReference type="GeneID" id="5856889"/>
    <dbReference type="KEGG" id="mgl:MGL_0358"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0358"/>
    <dbReference type="InParanoid" id="A8PT29"/>
    <dbReference type="OMA" id="ERYWIMA"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="12">
        <location>
            <begin position="344"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="14">
        <location>
            <begin position="632"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="13">
        <location>
            <begin position="867"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP45369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1243" mass="137435" checksum="990BC1A78C6A8326" modified="2008-01-15" version="1">MQMLTKFESKSNRVKGIAFHQKLPLLAASLHNGSIQLWNYQTGTIYERLEDHEGPVRGVSFHPTQPLLVSGGDDYKVKVWNHKTGKVLFTLHGHLDYVRSVFFHHEHPWIISASDDQTIRIWNWQSRTCIAVLTGHNHYVMCAQFHPYEDLIVSASMDQTVRVWDFTTLKQKSTTAQPMGLEEQMIRASSAQMDLFANMDVVVKYVLEGHDRGVNWAAFHPALPLIVSASDDRQIKLWRMSDTKAWEVDTCRGHYNNVSAALFHPHAELILSVSEDKTIRVWDMGKRTAVQTFRREHDRFWVLTAHSHLNLFAAGHDSGLIVFKLERERPPFALHNQSLYYVRNKQVRLLDYNTGKDQALLSIRRLGNQYVQPRSLSFNPAERSVIVTSLNGDVGVYDIAPLPHTPPTELSESGSVGKRGQGSTALFIARNRLAVLQKSQQKVEIRDLLNQNVKTLALPQPTNEIFYGGPSHLLLSTPTNVLLFDTQQQNVTGEIASPAVKYAVWSPDGSHVALLSKHTITLTDKNFAKSHLIHETIRIKSAAWDTNGVLLYSTLNHIKYALPQGDVGIIKTLEQPLYLTRVKGSTVYSLDRQACPRTVAIDPTEYKFKLALLQGRYDEVLSIIRTSRLVGQSIIAYLQKKGFPEIALHFVQDKTTRFDLAVECGNLDVALETAEAINVPEIWSRLGQAALRLGAHHIVERAYQKTKDFDQLSFLYLITGNADKLGKMTNIAERRGNVQSLYHNAVLNNDATTQARVLQGAGMGVLAYLTAQRAGDDAWAAEIAQEAGIEAEEAHAALGECAPTAAGLPPVRFATSQQDWPLAEPKENYFDKELLAGTDGGVIFEDNAVNAPTHDIDSWLEGDAFAEEGDDIDDEYGDRSGAMGAPPIDMNAAEEAWDLDEGVVAPAEEELGQQIAPLADVASLEGLAPGSAEDEHWLRNSPVAADLAAAGAFDTALQLLQRQAGIVAYEPLVPWLWRAFVAARAVVPGAPGMPPLVVHMRRNNEASEGDLGKVLPASPLRLAYLESHTLASAYRAVSANKLQDAEHEFRSLLHMLVLTPAVDDTEAQRISELMGECREYLIGISIELERGALATSEPDQVARILELAALFTHVQMQPQHQMLALRIAMMEARRVGNLAMAGHFARRLIELQPPAKVVQVAQQIVSLSDRQPRDVVPVPSYSVHETDYVVCAGSHTLIPAGGANAVLDPLTGAKYLPEFRGTLCKVSGISEVGRFATGLRNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT81</accession>
    <name>A8PT81_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732607.1">
        <property type="nucleotide sequence ID" value="XM_001732555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT81"/>
    <dbReference type="FunCoup" id="A8PT81">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT81"/>
    <dbReference type="GeneID" id="5856913"/>
    <dbReference type="KEGG" id="mgl:MGL_0382"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0382"/>
    <dbReference type="InParanoid" id="A8PT81"/>
    <dbReference type="OMA" id="HRIWIDC"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="327"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="658" mass="74628" checksum="9944C93CC73F179C" modified="2008-01-15" version="1">MDVHHACVSMHPTAYTCDNVYGYVYVSSEDATMHAKHMALGFRVPDQPAHPFAFHIPLAELQSIREHAPSAMRPIGYVEIVSSSHKPQTLFYHKDPFDDQRSPNDWAGHRLIDALVPFVDVLASRETPHLFLLDPSPEDRARHQTPHFADDAIDAVLSRRSPLPPQKSRPDTLTSWAKSTHMSVLTQLSHVVRGARDSRDAILAHPLVRRAKPHVSTAQAGPYMVSAQSSTPLLSPDHPSLEFDAARVYLAKWASQVAKEGELNRIAEHAMDDGPERDAESLLGASNLPILPASDDKIPPLSYDVCTELLNTGAPAHAVAQQIFRFGLASNARALMWPYLMGALPLESDVEKRRCADGELASSYKAWMSRWFGHAVTSDTLEASRHRIWIDCLRADTKHAFFQTDACNKSIMLQVNQSGWSRPSPQGSSDTQVNPHLYVLSNILWTFEVYAEHAHDLLLPHVEGYVQGMSDLCSVCYVACEGDEPRTFWTFVAVMRQWGCHYVADQSGMRHELLLLQRLVAELCPRLYEYLQQIDGLNLFFCFRWLLVCFKREFELHDVFRIWEAIWSAGWSRTEHRGWPLCSHLHLFVALAILESHERLLIRHLRSFDEVLMFIHSLAFHMDATSVLRRAEALVYRLRSRVVQGNDVDSELRSMVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTE0</accession>
    <name>A8PTE0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732634.1">
        <property type="nucleotide sequence ID" value="XM_001732582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTE0"/>
    <dbReference type="STRING" id="425265.A8PTE0"/>
    <dbReference type="GeneID" id="5856940"/>
    <dbReference type="KEGG" id="mgl:MGL_0409"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0409"/>
    <dbReference type="InParanoid" id="A8PTE0"/>
    <dbReference type="OMA" id="DWFARHQ"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="474" mass="53289" checksum="C93B140DEB50EB98" modified="2008-01-15" version="1">MARSGSKRSRKKHETPRDTDSAEPSFVLDTNSENVRPEASITRNEAHEVPRNATDLDLPEHVAIVSDRSRPVDVYQAADTGSVESATGQDADGAYEQLDADGTRYYEAEANNERKRKGVCPVCGEAGHEKKRCPYQQDCPVPRIGGRSRTCERCGSSSHPETTCHTWWRLYAYNTPEKHAYARAKKYRHELRRQEREHAREKKQQKPKPGWAASLVMMPEDVDDDAGPSDDSSDSSSNSSGDADTNDAARKRMTSSRNTVPLPPSDWDPALKVCYNCASVGHHWGDDCFLRRTNPTRPTGDPSPFSEVIANAGPYSQAYAVRDGSVRSHAPDLTIPPPPRRKRSRHSFSGRTSSLLEDLQNSGSTNKDDDDDDDDDDDWFARHQKLREQESFLSDTDDTNSHMRRPKRQPSRPRGSRSSSTVPPTTPTAHQHRRGSRGRGDHFGHRRGRGHVDRVPHHRPGRPTFHPRYRGGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTF5</accession>
    <name>A8PTF5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0416</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732641.1">
        <property type="nucleotide sequence ID" value="XM_001732589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTF5"/>
    <dbReference type="FunCoup" id="A8PTF5">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTF5"/>
    <dbReference type="GeneID" id="5856947"/>
    <dbReference type="KEGG" id="mgl:MGL_0416"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0416"/>
    <dbReference type="InParanoid" id="A8PTF5"/>
    <dbReference type="OMA" id="DHGMDEN"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="678"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="809"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="850"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="931"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="974"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1024"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1100" mass="120304" checksum="D2467820E8BB9287" modified="2008-01-15" version="1">MASPRVGKALAARAPFVAVLAILGLVLLLHLAGLVLFTSGFLLQRVELNAINTCTKAPSATWQAPSPPPWAAHGNETALDAWDAVLDAHAECSLPPRFRRTVLWIIDALRYDFIADAPDSPPLAMPNPFIHNWIRTPATYTNTTPRSSFLAHFVADPPTTTLQRLKGLTTGSLPTFIEAGANFGGSGRVLEDTWIAQLRARKAPQERLSFVGDDTWQMVFANLFDEAHPYSSFNVEDLDTVDAGVESHMLRAMDQDDWTLIVAHSLGVDHVGHRFGPAHARMPPKLEQMERLIQDVLHKLRDDTLFVLLGDHGMDATGDHGGDSELEIGSGLWMYANTPFDPAARSLFGSASSPSTTSLTEHPDVTALLRDTPTSTPSFQPFSLLPIAPFEQGHRSLPQIDLVPTLALLMGVPIPFNNLGTVMPELFASDTQPLQSASSRLLRALRINARQIKTYLDAYAKHSADLKPFSAELRHAWLTALQADAVFAEHATHDHARKTAQAYMAFTRLALARAQSVWAQFEYVRMGLGIAVLASSLVVTWLLWHRAFSSTTAALARMTWQASWLGCVYGGVAGLLLSLTLRISTLEGQLAGMALGTACTLTWHLRPGHMAIDAFPVLRSKSFVSHVAAGVILGCHAMLYASNSFTMWEDRITLGMLTAILLARAWAGLVAPLTRWQLRIPIMAVIALVLVRVASMSRVCREEQAPYCTPSFYAYHATTDFADNPAYALSGPATNSPYALLAAYVVAFGIADVLRQALMPSRAHLSTASTLLTWVIRPAMLGAAGFWLADWVHGLDRWDEPTRATFFVVKMWVARVVLVVLLCGSVYWYLSPLSLSVLHERPAPGAQARVLLLGFGNTFGAAFLLAMSLIFAYLFLLSQPMGQLALTACFVALLLLAELGDHERDARLLAASKLAEATKTKEVTSTRHGPSFLDVVCVALLGFVAFFGTGHQATFSSIQWRVAFVGFSTVTYPWSPLFVILNAFGPLCVLPAFGVVLLTLWNLAPTRERPDEERPPPMRLPCDILRSALALLLYAGTLTLSAATWAWFFRRHLMLFKIWVPRYMTAGLGLLVTDVALLGAVLTAWCIASHTSRAFGTLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTH2</accession>
    <name>A8PTH2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732649.1">
        <property type="nucleotide sequence ID" value="XM_001732597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTH2"/>
    <dbReference type="FunCoup" id="A8PTH2">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTH2"/>
    <dbReference type="GeneID" id="5856955"/>
    <dbReference type="KEGG" id="mgl:MGL_0424"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0424"/>
    <dbReference type="InParanoid" id="A8PTH2"/>
    <dbReference type="OMA" id="RPRYMNP"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="631" mass="69304" checksum="8399B0175395C6CB" modified="2008-01-15" version="1">MAATGEPTTIQAASGHTSSEHVDTHDADDTEKEKDIKPEVADRESERAPMRRSRRTNAQEVSEQPAHKDEERAQEDMDVVRDEELASAGQMDSHDGGDEGVTRCVCGSTDENLGLMIQCETCKSWQHCACMGMHTEEDCPDVYYCEQCRPENHIDLLRSLGFLSSNKIVKRGASRGGGRHVFSKESAQELREARDAIRAMALDNAARLRGDAVPARERRSGAIGRSSPEWRTTPKRRTMNSRDFGEDGWEPIPPELLRDEAVGMDDESEDSRKRKRHMEQSEETSESLSANSHPSELSKRRRMQQLPESPRKDRRSDEAKREPVGTERTRKERGGVASRDADIKPKHPNQYTYRNRQEAASATDVESAKGSAAIVSTEPAGPATAASGPWGTNGATAGVSSARGMSPNRANGSTSSSTNGASSSASTSSTSSATNSQMPLSAVPSRTREGRRAATRAENASRSGTPSQENAGRGTAQNNTLPEHLAHLAYLLPPSADDDTDAERPQLPCAPKKGMPEPFQYVTAVDPAIRIRFPQKRMTMGEMRKRVRTTGEYVTRIQLEAVEREKRVGFLASVGLSSSTSTSTPEQRDDHISELPLSMQLVDQLTRDLTSFQRRFGHNAMISRSDEVSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTP9</accession>
    <name>A8PTP9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TATA element modulatory factor 1 TATA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732684.1">
        <property type="nucleotide sequence ID" value="XM_001732632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTP9"/>
    <dbReference type="GeneID" id="5856990"/>
    <dbReference type="KEGG" id="mgl:MGL_0459"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0459"/>
    <dbReference type="InParanoid" id="A8PTP9"/>
    <dbReference type="OrthoDB" id="2505754at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026139">
        <property type="entry name" value="GOLM1/CASC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15896:SF10">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_98, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15896">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 2/GP73-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="64735" checksum="2F0C09564DE4ACB2" modified="2008-01-15" version="1">MAKKESRPTPPPRSEARSSRGPPIREKSHARTGSKDSDTSEPPTSHETEIHATAHGGDSAPESAEVTPASEEVLALGKSLAEKDAEITELHSQLALRQEVVDKAELAVKERDEWLRKERELVAQLQKQISVQQDSIRALNEQLKRNQEESAQRQAQVNESDGSMTVIKTQLKKSIDECEQLKQNIAEQQKKSQEELDGKQSSETASTQRAMDLSTQVESLSMQLSNAEAQVSELQKQSIERNERVQELEKQDQAQVQAQSKRVEEEWMPVQQEVERLRRQLKERDEQVDQLRQKLELTAARVQEPESSVLQAQSSCAPPANWVNEREQMVAETARLRAQLEGEQSRADSAEERVRDLRYTNEESRRAIMRLQSSRPSGSRSDHEPTQRHVRRSSHILSTLAGRSSDNDTEHERTGLRDLRLVSPALMGNEEFSPPTASQARMDDTHTDYASPHAAGEDAASSSSNMQASGITGLFPSSLLRSSLGLTRKSTPAGSDDTSSWPLREDFAAADELRSEYGKLQRELLALKEELGTMQHQLTESREAEQASQTMITSLREYIMVTSQTGGTLTGAGKHVDAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTW3</accession>
    <name>A8PTW3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732713.1">
        <property type="nucleotide sequence ID" value="XM_001732661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTW3"/>
    <dbReference type="GeneID" id="5857019"/>
    <dbReference type="KEGG" id="mgl:MGL_0488"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0488"/>
    <dbReference type="InParanoid" id="A8PTW3"/>
    <dbReference type="OMA" id="NPRRHES"/>
    <dbReference type="OrthoDB" id="3347370at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="355" mass="38495" checksum="D3093EEA6FC164ED" modified="2008-01-15" version="1">MIRISSISAQLEALIGDDPDENGADTALIVCDRSADLYGYATKISKEQEPRPRAGLMAPETKTPPSSEEHARTLVAISISSWREKGMKKVRRNMSATSRPSNPRRHESRAARSGDHSSPDPTSKRYASIRQSALDGTWVSSDTEDKSGSAMDGESEHDTSAPLLVECEHGRLLIARIYVPAISEQYERHREQRMLQVPTSHIGSRRHSYANSTRSASGGGDVSKTAQNAVTNLRSQFTLEDAMDPGFSTEDETDLDSMWSDAIRHDINMNMKMNELLLVLHAPGSGEHAVTWPTLLQQAIAFADMNPHPTSKHKSSQTSSSSTLSANAAIDTASSISPATTPAAAKSSPTNLVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUS9</accession>
    <name>A8PUS9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732171.1">
        <property type="nucleotide sequence ID" value="XM_001732119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUS9"/>
    <dbReference type="STRING" id="425265.A8PUS9"/>
    <dbReference type="GeneID" id="5856477"/>
    <dbReference type="KEGG" id="mgl:MGL_0764"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0764"/>
    <dbReference type="InParanoid" id="A8PUS9"/>
    <dbReference type="OMA" id="AITKFAM"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="4">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="5">
        <location>
            <begin position="163"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34478" checksum="7CDF92EC9BBE66A7" modified="2008-01-15" version="1">MHRVFVQTARLSTSAPRLAFKEFSMPAMSPTMEHGNLGQWKVKEGDTFAAGDVILEVETDKAMMDVEAPDDGLMARILKPSGSKDIPVNEVIAILADEGDDISQAPGAEDVNKGKSGTSTSSSSPSFSSSSSASQPTESHKRESPSETASHAQRNTHVHVTKPTFPSVLRLAHERGISDPESKISGTGRHGMITKGDILAYVGETGSAFGTASPHHTTISELGDGKTRESGEKLTNQASPPKQLRVDEQRSMIISGLAAMAAASRKTTKETKQTRRIEFADIVQQYVPRKDMDTATHDKKNRAGSSASTSLQTIYEQLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUT1</accession>
    <name>A8PUT1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732173.1">
        <property type="nucleotide sequence ID" value="XM_001732121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUT1"/>
    <dbReference type="GeneID" id="5856479"/>
    <dbReference type="KEGG" id="mgl:MGL_0766"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0766"/>
    <dbReference type="InParanoid" id="A8PUT1"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="119" mass="12832" checksum="10D8F1909EF62C17" modified="2008-01-15" version="1">MHADACAAQSGHGTVDEGDERLFRYLLRTADVWVSINELPSGRAAACDGEIGVYALVRPTAATTSSSNEALQPFLLDRYMPASTKHLYRILPDGTGPKQEDGTRALVRVWSRGSGADII</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUW8</accession>
    <name>A8PUW8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0789</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732196.1">
        <property type="nucleotide sequence ID" value="XM_001732144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUW8"/>
    <dbReference type="FunCoup" id="A8PUW8">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUW8"/>
    <dbReference type="GeneID" id="5856502"/>
    <dbReference type="KEGG" id="mgl:MGL_0789"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0789"/>
    <dbReference type="InParanoid" id="A8PUW8"/>
    <dbReference type="OMA" id="PLDPMMS"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000594">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="220"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="409"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="865" mass="97687" checksum="CB36A262B35B17C5" modified="2008-01-15" version="1">MSKEPQPIAKGSTDFDALRHRSRQEYLAKRSQQQVELLRQEIRDEETLFRGVRMTKREERELEHKRELLRIAEEFADLDDGDGGYVLPEDYLTEQGRLDRKRKESALHERRYDDAWNERASRKKQVSDGDLFEKEQIARSKLLESPQPAHAEGADAFDFVFDESQAIQFIMDRQADGQLNTMSDKELALQQQLQEAETRAQTVEATRKSLPVYGLREELLDAIDKNQVLIVVGETGSGKTTQLPQFLHEAGYTKEGQIVACTQPRRVAAMSVAARVAEEMGVRLGHECGYSIRFEDCTSDKTVVKYMTDGMLLREFLTNPDLGSYSAIMIDEAHERTLSTDILFGLVKDIARFRSDLKLIISSATLDADKFSEFFDDAPIFFVPGRRFPVDIHYTPQPEANYLHAAITTVFQIHTTQPTGDILVFLTGQDEIDAAMESIQQTARALGGSVAELIVCPIYANLPSDMQAKIFEPTPPGARKVVLATNIAETSITIDGISFVIDPGFVKQNSYNPRTGMAALAVVPCSRASANQRAGRAGRVGPGKCFRLFTKWAFQNEMDENTVPEIQRTNLANVVLLLKSVGIHDLLNFDFLDPPPTDTLIRSLELLYALGALNDRGELTKLGRRMAEFPVDPMMSKAILASEEYHCTEEVLSIVAMLAESASLFFRPKDKKVHADRARQLFIRPGGDHFTLLNIWDQWVESGYSQVFCLDHFLQPKTLGRVRDVRDQLVNLCERVELVPESRLSSADLTPIQKAITAGYFMNTARLQKGGETYRSIKQNTTVYVHPSSCLYKHVPQPRFLCYYELVETSKNFLRQVMEIQPEWLLEVARHYFSRDDLHDDTKQKRMLRGAGAAPSTARSGTAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVG7</accession>
    <name>A8PVG7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Antiviral helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731592.1">
        <property type="nucleotide sequence ID" value="XM_001731540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVG7"/>
    <dbReference type="FunCoup" id="A8PVG7">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVG7"/>
    <dbReference type="GeneID" id="5855898"/>
    <dbReference type="KEGG" id="mgl:MGL_0860"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0860"/>
    <dbReference type="InParanoid" id="A8PVG7"/>
    <dbReference type="OMA" id="DHVNIIM"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="278"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="550"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1224" mass="137307" checksum="D1CB35814FC72B82" modified="2008-01-15" version="1">MWEALALLPGADAEACRTAIADEILEPTYGLDASMMLSSQTHWDREQQFEQMLALDPSPCITSLQFIRSGLKGRVIGYREVVADAVKRGEEAIDMSLQRPLASKQNYVRGSLTSTPFRPGGLQDVDEENEDIEEGDLGQMPGTDDVHFRTVPPGFSRGLNVTAPEFLDTTAPAWMGDVQDVAPRFLDRHVITVDDDGLYKRPDVAPPPKNDDAKVDELLPDEYLPRLLQDSAARPTQEKREWAHMVDSSKKMSNFHELVPQMAHEYPFELDTFQKQAVYHLERNDSVFVAAHTSAGKTVVAEYAIALAMKHMSRCIYTSPIKALSNQKFREFKQAFGAENVGIVTGDVKINPEAACLIMTTEVLRSMLYRAGELIRDVEFVIFDEVHYVNDQERGVVWEEVIILLPAYVNTVLLSATVPNTQEFADWVGRTRRRDVYVISTPKRPVPLEHFLYAGKQLHKIVDANGRFLSKGVNEAADALLSKKEREAAYTTGSSAQRGHRGGRGGGPAGRSGGSSGRGGGNSSAGGGVGRPRPSMASDRSLWVNIVGLLKKQSLLPVVVFVFSKKKCEEYADSLPNTDLSTAKEKSEVHVLIERSLMRLKEEDRQVPQIARMRDLLSRGIGVHHSGLLPIVKELVELLFQRTLVKVLFATETFAMGVNMPARSVVFSGVRKNDGNKFRNLLPGEYTQMAGRAGRRGLDKTGVVIILSDNPELNPLNRMILGESTKLKSQFRITYCMILNLLRIETLKVEDMIKRSFSENAAQKLMPQHQGRLKNLEHKLHAWTKRLESSASLPIDALSRLYDLSNKLVRVNDNLLALAYEHPQGAKLFSSGRVVLVYTGTHILSPAMIVRLASNKKFLVLLAVLPDQQPLEKHQAPFWVTSKLAKDMARDSEYMPELQEVSLSKIAFVSSFSVPIPATLFQSRRQAKLQQGLDLLRPSIEQIRNHLEAAGDEAARAILDLEADWSRVRRIDFQDTQKDRNQILSELIPEQGLMQKPGFDKEFKLLTICKLTEWEMAKVSASLSNQNLELLPDYHQRVDVLKELRFIDPESETVMLKGRIACGIRSVNELIMTELILDNTFVDYEPHEIAALLSVFHFRENTSLTPELNDTLQRGLDHISKTADRIAAVQMAHHLQPEDDASTLHTGLVEVVYEWTRGLHFSDIMQLTDVGEGTIVRCITRLDETFREVRECASVIGNAPLYQKMETCQQLVRRDIVFAASLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVJ1</accession>
    <name>A8PVJ1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TALE/M-ATYP homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731616.1">
        <property type="nucleotide sequence ID" value="XM_001731564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVJ1"/>
    <dbReference type="STRING" id="425265.A8PVJ1"/>
    <dbReference type="GeneID" id="5855922"/>
    <dbReference type="KEGG" id="mgl:MGL_0884"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0884"/>
    <dbReference type="InParanoid" id="A8PVJ1"/>
    <dbReference type="OMA" id="VLWFINT"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="126"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="309" mass="35651" checksum="A318777141FED1C1" modified="2008-01-15" version="1">MLTQEEVRQKLLEFEYTLLDALTREVDESYYSHLRQLTEIVRREFALQQEQGTLTNATLQLGARVSDRLEQLGHILHEQRTQMQRIHSNASQELVLILRSPIPRSRASGSLRDRRDPTLNAKHMRDWFLRHLGHPFPSREDKEQILAETNACIRDRTLRLKYTQIVLWFINTRRRSGWTAFLRHYARGDKVKLFNLAQAIENEEGGTHETRQWSAGHAITLTPASAVQANKPMLSDPNTSSGLSLQSLLPNMDDIARRAMKREWSNIVDRVRIGAKERIGDWVDEVISAPSTASSSSQSRRHSTRRTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVK9</accession>
    <name>A8PVK9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731629.1">
        <property type="nucleotide sequence ID" value="XM_001731577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVK9"/>
    <dbReference type="STRING" id="425265.A8PVK9"/>
    <dbReference type="GeneID" id="5855935"/>
    <dbReference type="KEGG" id="mgl:MGL_0897"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0897"/>
    <dbReference type="InParanoid" id="A8PVK9"/>
    <dbReference type="OMA" id="TSIWHTL"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="73597" checksum="884FA8CDC957CCFE" modified="2008-01-15" version="1">MVASSDRSAALDWSKAASLAMNRTLRQCDHAARVDLVHLVRCVRASDARAADIAQLCRSHILQGTLPPPAARPELYSLALCVAAHESDSVFHAWQQMRALYPAWIPHRDDASWALQSVLAARQCDDAWLLWNDVRALDVLPRAGAINALLASLHTQPEATQLLVELGVRQLDVVGLSTFVHAHVKECMLSRLTIDAVVHEAADELQKRLASSHDAIAWHTILLYEGHVNGPDAALARAEAALTRQAFLPDAYTVSTLFQCYDPTHLTTCDEALGVLQRIHATVGVQPTAHALSMAIHAVLGHGHHHSLGSVTSDPQQVSEASALYKEARSLWSMEPDPALLQPLIEAHCAAFVPALDQACLLLQEYLSEDTDSWMSTSRTSLLARFRLRKPRQRQVDLGLFYPLIIACARLQDVPRALDVLAQLAQRRVRVPPHATITMTKRLLSACSTYDDAWLVYHRAHALGGWTHDTYARLVAFLCRLVLDGESAPPELPLQVLADMRSAGFHPSPSTYTILLDFYAKTHATLAGVRATHELIQRDMHLEPDLVLIHALMNAYNYAGAPAQVLGIWDSLMVLCHNAGAPRFLDDVTVTIVCDTCGRAGLLGVMREILATVRRQYAHLMTKTVYDAWTECLARCGHLTEAVDVVVQDMCAHTPIYPDKRRCRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVQ3</accession>
    <name>A8PVQ3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0928</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731660.1">
        <property type="nucleotide sequence ID" value="XM_001731608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVQ3"/>
    <dbReference type="STRING" id="425265.A8PVQ3"/>
    <dbReference type="GeneID" id="5855965"/>
    <dbReference type="KEGG" id="mgl:MGL_0928"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0928"/>
    <dbReference type="InParanoid" id="A8PVQ3"/>
    <dbReference type="OMA" id="QMQAVYP"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="566"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="333"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="496"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="684" mass="72310" checksum="1659151F53248F11" modified="2008-01-15" version="1">MERPDAPGAGSLGPEQRGFSTTSCTDSVLSDTSCPPSYDPFLPSSVFGAGDVPPFDSTANLLSSDIKNETSSWDTHDSLSIDLGRVSSLTLGTPISQGRHPVTEQPHPYPSPQSVQPLELPPQSYSPLHSPSQPQPQPQASAPAPAPAPAPPHSVHTIPFTTSPVPQTPCAPRRHGSNHSSIASSADEFSHPSDVQNVSPYQASLPHNASTTGSIPMTPLTQSDRTSRHTADLSTSSYASLATPEYGPPTGPRFSSVPDVFSPYIPPPDLSAYRTAAPETSPTPRKSCTLPVYMESIPGTPDVTSTPHPLCMPPMPPTSAGPMTSPGGQILLDDPFVPMPYYTPAPTSTLPPPTPPPPPPPPAAAPSGPSSSMPHRSHPQPPPHPYAQSHASLHNILPMEHGNGLSQHAPPMMSRVLSAPVGPLWPHESPGPPIPYTPIQERSLPTSPASNGGYALPVSSVAMARKCFTPYSKQNSIYSWPYHEMEYYSSSMSASRSMGSLASPLPTSPATPSGPSRRGSQMSHSISMPGDQIPALLDFERPSPSRQRGRNPGPPPLVVSSADKLHVCHCGRRFKRMEHLKRHTRTHTQERPHKCPVASCGKSFGRTDNLAQHLKTHFRPAGLAGRSSELAPLKDNTPATHMRNDPFAAAAAAAAAAAAAAAAASTSSTTTVPLPEHDKIKQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW50</accession>
    <name>A8PW50_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:intracellular manganese ion homeostasis"/>
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    </dbReference>
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        <property type="term" value="P:iron ion transmembrane transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
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    </feature>
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        <location>
            <begin position="186"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="416"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="454"/>
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    </feature>
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        <location>
            <begin position="460"/>
            <end position="483"/>
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    </feature>
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        <location>
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            <end position="589"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="598" mass="65853" checksum="47CCC1E24E217742" modified="2008-01-15" version="1">MGIPQRQLHPQPWYKVVGDTLMRHISFLGPGLIAAVAYCDPGNWATDMEAGSRFGYKLLFIVLLSGLFAVLLQILCCRLGAVTGLDLSTQTRRLVLGLPIDQSESYSMPLWKYRLRYWGLLIPLYIVNEVAIVATELAELIGTAISLNLLFPALPLWAGVMITTVDVFLVLCLYRPSSGIRLFEMIIGVLVLIVLICFCVLLGRVRPNWGDVFHGYVPSSTVISSQGLYISISILGATIMPHSLILGSHFATIDRLDGESDLDSDSSSVQNEPTDEGERPTHDASTSRYRTFRMMRSVWRRLVAPNIRVPEVLQTDKIPPLKAVSFQYLNITLQHSSWDIAICLVLFAITINSAILIVASAAFFYGHNEKGEREVVGDLFQAFALLRDTTGKSTAILFAVALLAAGESSSVTVTLAGQIISEGFIRWRLTPFMRRLLTRAIAVIPAMIVAAVAGRDGLDSMLVASQVALSMALPFVSFPLLVITCSPKRMSRELAEDSSVPVCQAELSPSQGPLCLDTAGPSRSREPSSVSSKLFHIYNGIYEFVWPSRAYVDFDTGKFFYKFHNAPPIAILSWCVFLLICIADMYVLITSIQNPSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWD3</accession>
    <name>A8PWD3_MALGO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731805.1">
        <property type="nucleotide sequence ID" value="XM_001731753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWD3"/>
    <dbReference type="GeneID" id="5856110"/>
    <dbReference type="KEGG" id="mgl:MGL_1073"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1073"/>
    <dbReference type="InParanoid" id="A8PWD3"/>
    <dbReference type="OMA" id="QWIMSEK"/>
    <dbReference type="OrthoDB" id="5541877at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039966">
        <property type="entry name" value="C553.12c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="249"/>
            <end position="272"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="304"/>
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            <end position="355"/>
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    </feature>
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            <end position="413"/>
        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="695" mass="80400" checksum="C1BB1A610E720A94" modified="2008-01-15" version="1">MAAPVANTSSGRDLPSLSNEEQALYPEPWNGSTIYTVNESESASDSEYENIASDQDNPTAFISPVSSRHRISLIPPSPQLDAASEDTFWLGHDTRRSHRRTVRLPFDLSTDWYLGGGGNVFWGFHRQRRRHAIPGTYGTLDQSTPQAHLRHGDSSSRALGPVGFRTQSTFRTMESPDPLLQQPASPAPNTRPMLEHAFRPTTQVIDELLSSSPRRLCVLIWIPVLLVLLWCGMPFPLDDGDPRSSNATFWFFLLWYYGCYVSVALIFVTQLFTLYRLNWWPASIGARMSYTFFWVLSLWIGYIIHKLEPTNSRDKTSHATNKAHKHEPEWQLKTEWVLLTFATMSMPAFVCLIGLRRSGRQRYRLSVTDVQKPFASTEAAWRIPSSYRRFLWFMASLGLSLFTLLAGQSYAIVYMNTLPHTGTDGTLYVAFWMLTVHVLSAIVQWIMSEKVRSRALLFAFKYYYFMVYFIFYRNLFARLRSFDQFALIQLLSSTWVCLWYPFCMSQTWLWILNRFSSRPISHGMHVEKISLYFYLRTIAQHTTMLAFLGWLSLLHFGINQPLYPFFAFDDNDPYNYRLTMLGSLAIWASEMISNLFTALLCRAFYGVHAAHLGLAEMRLYPELVPTLVWTSLHVLMNMLFFLIVRVFIYNMLRSKHGRSHIHPRNLTSSLLSQSMSQLLPWAYDPLRCSRAIYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWE0</accession>
    <name>A8PWE0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
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            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731809.1">
        <property type="nucleotide sequence ID" value="XM_001731757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWE0"/>
    <dbReference type="GeneID" id="5856114"/>
    <dbReference type="KEGG" id="mgl:MGL_1077"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1077"/>
    <dbReference type="InParanoid" id="A8PWE0"/>
    <dbReference type="OMA" id="HESYVPE"/>
    <dbReference type="OrthoDB" id="10544743at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF27">
        <property type="entry name" value="CHITIN-BINDING TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="366" mass="38906" checksum="CFCF3E9359A58B4A" modified="2008-01-15" version="1">MSHLMPRQEVTTVVSHTSSVEAPGRTVTLERTSTSYAPPPPQTNSPEPEKNDSSTPAGPVAGGVVGGVVGLALILGVLWYLIHRIRRNRATRALDDMYAETGMGGGGVDRHARTRANNPATMPLSSSWDSGTPIHMEQDMYDAPMAVPTDPTQTAFAAPIHSQARQDSLDAPGFITHPLEADVPWQTHIIPEDPSVSVAHQAPHESYVPEALRVTNAGLEPTTPPSMPAYAQEAEQAVEENPRMGTLISERTQPPGTGTQVNPTLLTVRPDNSTSPNGTIPPGTSHSGTALQSTPAELSVNTNHLERNASLAEDERSPLSMYMWLPSHKVAGITSPSQTASQTPATNTVSTGDYSTQTLNRVNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWI7</accession>
    <name>A8PWI7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731846.1">
        <property type="nucleotide sequence ID" value="XM_001731794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWI7"/>
    <dbReference type="GeneID" id="5856151"/>
    <dbReference type="KEGG" id="mgl:MGL_1114"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1114"/>
    <dbReference type="InParanoid" id="A8PWI7"/>
    <dbReference type="OMA" id="SETILDH"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="131" mass="14470" checksum="0C84B281B5CCCCE9" modified="2008-01-15" version="1">MSPKKAAASQKEPKSKLVVAEDEELTSATETEADEFIDSESKSAAPSESEVTASSEVIDNDNEDAESYEEENDGEDENDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDNNNDQYDDGNDGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWN0</accession>
    <name>A8PWN0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1157</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731889.1">
        <property type="nucleotide sequence ID" value="XM_001731837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWN0"/>
    <dbReference type="FunCoup" id="A8PWN0">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="GeneID" id="5856194"/>
    <dbReference type="KEGG" id="mgl:MGL_1157"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1157"/>
    <dbReference type="InParanoid" id="A8PWN0"/>
    <dbReference type="OMA" id="SGCEFYE"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004483">
        <property type="entry name" value="SMUBP-2/Hcs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00376">
        <property type="entry name" value="IGHMBP2 family helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="238"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="721" mass="79458" checksum="03133469009F9206" modified="2008-01-15" version="1">MTTTSAMPPPPTASELHAWILRQQILLEHERKEEREQNALLLSKCPPRVLARHGLALLGLFVASSRTGEGGKLLVELQYSTALHASPVLGPHTFRPGDVCALEEHESSKATSCTLSLRAVVYRVSETSIILALDERSASHEDHETDLPPLIRIVQLANEATYDRLVETLESLARVMGLPTQQDVPAPELELSAHAPRVVRSLLGLETPAWRKETPAWIPIQPHLNDTQRGAISFALRSEHLALIHGPPGTGKTTAVAELIVQLATLDPKARILVCGASNLAVDNLLERITSPAYKDALARADARVTRIGHPARVLPSLTSATLDVQSRQSSEGQLVRDVAAEIDELMQRLVPPRTGARAGNKSARNIPRVKGLERRKMWEQVRELRKEYRRRDRALSNTVLKNARIIMSTCHGAGARQLDDMQFDVCIIDEACQALEMSCWTPVLRLAPHGRVFLSGDHLQLPPTVMADAPRLPAGSGTLRPSASLEVTMFDRILDMYGEGCKAFLSVQYRMNREIMAFPNSQLYKGQLVAHESCASIRLTDLGVEGDDDDLFCAPLVLYDTTGAGMYEREDEAVLSTHSRVNENEVALVLRHMELLVEHGIAPESIAVLSPYSAQVHLLSQQIRSAYGARVEVGTVDGMQGREKEVVIVSLVRSNDEHQIGFLQDSRRLNVAMTRAKRQLVIVGDADTVGEGKKDASAPRKFLHAWTEHLHSQALVEMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWY3</accession>
    <name>A8PWY3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Translocon-associated protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1259</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731991.1">
        <property type="nucleotide sequence ID" value="XM_001731939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWY3"/>
    <dbReference type="GeneID" id="5856296"/>
    <dbReference type="KEGG" id="mgl:MGL_1259"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1259"/>
    <dbReference type="InParanoid" id="A8PWY3"/>
    <dbReference type="OMA" id="NNPFNIV"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725377" description="Translocon-associated protein subunit alpha" evidence="11">
        <location>
            <begin position="23"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28021" checksum="F481EAEDEFB8608C" modified="2008-01-15" version="1">MRYAAVLVLSLWFLSFCALVHAQSHEDPPEINVATTFPNNPFNIVKNGEATRVVFTFSQPRGADRAVSVRSLTGAFLDPARQDGHKRRVLRNMTTRVMHDDMLIQIVDGKPLQLPFDVYSEFKPQKLDVEFRAMVSDRSSSNNYNVLLYRGSVTVEEPPQSLWDWQLLSVYAIVLALLGGVGYWMYNAYIAPMLRTKTVPTKRRDAKTTPVAVSSNGKTYDEDWIPESLQNQQQRPRTRKNRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWY4</accession>
    <name>A8PWY4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1260</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731992.1">
        <property type="nucleotide sequence ID" value="XM_001731940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWY4"/>
    <dbReference type="FunCoup" id="A8PWY4">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="GeneID" id="5856297"/>
    <dbReference type="KEGG" id="mgl:MGL_1260"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1260"/>
    <dbReference type="InParanoid" id="A8PWY4"/>
    <dbReference type="OMA" id="AASNTWV"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725021" description="Peptidase A1 domain-containing protein" evidence="13">
        <location>
            <begin position="27"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="211"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="530" mass="56348" checksum="E5D46D5B3711BF80" modified="2008-01-15" version="1">MLFRLTRPGTFSFFVGISVLLHVILNDLTGSSSVAPLFANAVPMSSDNSTDTKSNGMVHLLLSSNFEEEGEQFVHPWIKLQQHINRSKRRLAKFQGTSAPSDDELQASIERRKSSVNNEAQGPSHAMLEFRPPRIKSRPQSQTFEDSKPKRRHSRYGTTEKSVKPDLVPRDDDGYSSMEAKMQKSYSVTNAPGASARNSEGLAIEANDVGYFVEVQIGSSDTKFKMLVDSGSSDTWVTGTSCNECGSSDRQKLGKSVSQSLKTTNDKYKISYGTGSVSVALATDSFQIAGLSLDSYTFGIASSESDDFGADKIPFDGLLGLGGKSLSITGKPTIVDALAQGNKIDKPIVGVRLGRAAEGSSGNKGQITFGGVDQSQIDGSLNQLDNQSKDGYWAVSLDSVSIDSDQVSGGSTAVLDTGTSLIVAPKSAADKIHDAIPGAKSDGQGGYTIPCTTSKTLSFTFSGNTYSMDARDLLFAPKDPNNLKGTCISAVSTGSTMDGADWLLGAAFLKNVYFATNSDANSIGLGKLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWY6</accession>
    <name>A8PWY6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731994.1">
        <property type="nucleotide sequence ID" value="XM_001731942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWY6"/>
    <dbReference type="FunCoup" id="A8PWY6">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWY6"/>
    <dbReference type="GeneID" id="5856299"/>
    <dbReference type="KEGG" id="mgl:MGL_1262"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1262"/>
    <dbReference type="InParanoid" id="A8PWY6"/>
    <dbReference type="OMA" id="FTSMNNQ"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="97" mass="10466" checksum="D74CC52DC8F167EB" modified="2008-01-15" version="1">MGVNVETISPGDGKTFPKAGDVVDMHYIGTLQSNGNKFDSSRDRGQPFRTKIGVGQVIRGWDEGVPQLSLGQKANLICSPDYAYGPRGFPPSTCTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX05</accession>
    <name>A8PX05_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732013.1">
        <property type="nucleotide sequence ID" value="XM_001731961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX05"/>
    <dbReference type="FunCoup" id="A8PX05">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX05"/>
    <dbReference type="MEROPS" id="T01.984"/>
    <dbReference type="GeneID" id="5856318"/>
    <dbReference type="KEGG" id="mgl:MGL_1281"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1281"/>
    <dbReference type="InParanoid" id="A8PX05"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="198" mass="22561" checksum="E4068F41E9DDBCC8" modified="2008-01-15" version="1">MECLFGITGKGYTIIASDGNAARSIIKMKSDDDKQKVLSKRLVMAYAGESGDTIQFAEYIERNMRLYSIRLMLSNNIDLRPKAAASWIRSQLAEAIRSRHPYQVNLLLGGYDEPTSEPALYWVDYLGTLVQVPFAAHGYASYLTLSTMDRYHRPDMSLDEGLKLLKQCIEEMRKRFVIDVNNFNVRVITRDGVHEVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX49</accession>
    <name>A8PX49_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731142.1">
        <property type="nucleotide sequence ID" value="XM_001731090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX49"/>
    <dbReference type="STRING" id="425265.A8PX49"/>
    <dbReference type="GeneID" id="5855449"/>
    <dbReference type="KEGG" id="mgl:MGL_1325"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1325"/>
    <dbReference type="InParanoid" id="A8PX49"/>
    <dbReference type="OMA" id="CRTEIAY"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="119" mass="14111" checksum="AB1B3C0058BBD390" modified="2008-01-15" version="1">MAPTIDSRNILRPETVESLYIAFQLTGDRIYREWGWQIFQSFQRWCQVDNGDGGYAGIDDVDNVDHKQIDRMETFWLSETLKYLYLLFARRNQLAFHDWVFNTEAHPLPVFEPSFSTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX50</accession>
    <name>A8PX50_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731143.1">
        <property type="nucleotide sequence ID" value="XM_001731091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX50"/>
    <dbReference type="FunCoup" id="A8PX50">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX50"/>
    <dbReference type="GeneID" id="5855450"/>
    <dbReference type="KEGG" id="mgl:MGL_1326"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1326"/>
    <dbReference type="InParanoid" id="A8PX50"/>
    <dbReference type="OMA" id="HSMARIF"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000002">
        <property type="entry name" value="Trehalose-6-phosphate synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="680" mass="76951" checksum="10DCA38A80B49063" modified="2008-01-15" version="1">MWDQYSWLSYVKVNQMFAERVVAEHKPGDIIWVHDYHLLLVPLLVRRMVPDAHIGLFVHSSFPSSELFRCLPQRNHILEGMLGADLICFQNQSYARHFLSCCVRICGLEVQGRCVELSNGRVTKVSHNIIGIDVERVRYEATAPGIGLRMHQLRNLYKDKRIIVGCDKLDVVRGVIQKLLAFYDLLLHYPQWRENVVLIQITIPAMHSSLKLERQVSELVSQINGDFGSLSFTPVQHYHQVIEREEYYALLSVADLALVTSVRDGMNTMSMEYVVCQKEHRHSPLILSEFTGTAGHLPAAIHINPWDIGGVAAAIHHSLCISDQERFERNIQCHDQVVSQTSRTWALSLVQQMLIRLRHRYSAHSTPILDTNLLVQHFRSARKRLFLLDYDGTLTPIVKDPAAAVPSQRLLDAMHALTNDTRNIVYIISGRDEAFLSKHFSQFPALGLSAEHGSYFKEHGIGSTWQNLSAELDMSWKGDVLNVFRYFTDRTLGSNIEEKKSSIVWHYRNADPDFGSFQAKECQSLLDNILSQNDLQVEVVVGKKNVEVRPLAINKGEIVHRILYSNPDTDFVFCAGDDKTDEDMFRFLSNLANDTSEKEPSSPTGGMNTMMIMPPAPLSRSSYVNATSLSLKLKRDQIFTCTVGPNSKRTRADWHVGDVHGVIDSLLGMVGTSRDATSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX75</accession>
    <name>A8PX75_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731168.1">
        <property type="nucleotide sequence ID" value="XM_001731116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX75"/>
    <dbReference type="STRING" id="425265.A8PX75"/>
    <dbReference type="GeneID" id="5855475"/>
    <dbReference type="KEGG" id="mgl:MGL_1351"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1351"/>
    <dbReference type="InParanoid" id="A8PX75"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="263" mass="29356" checksum="70426F9E4484B99C" modified="2008-01-15" version="1">MHMDYILRARLIRANKDLAEQLQRLWQEHQLKNACLVGMQFAREPCTTMPQLASWLGSKYLHVPSANDNEHVIEAQEQEALDLSLSLGYTAAAPTPDAETARHGNDEHARPKNVNWYWDQRSEPRCPTTSLSVYDANKSVSLTDAARLLLSEWPIGTSTDSYTYRPAYRGLDFDAGAALNSTPAGRFVSASQIVRPSIGRSNKPGKHTRQNDEPTSSPIYSSMQSSQPPSSQDGVVQTQLEPGRYARRRSMAAQPRKKRLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX91</accession>
    <name>A8PX91_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Protein transport protein SEC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_1367</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731184.1">
        <property type="nucleotide sequence ID" value="XM_001731132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX91"/>
    <dbReference type="FunCoup" id="A8PX91">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX91"/>
    <dbReference type="GeneID" id="5855491"/>
    <dbReference type="KEGG" id="mgl:MGL_1367"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1367"/>
    <dbReference type="InParanoid" id="A8PX91"/>
    <dbReference type="OMA" id="AVECSKQ"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="14">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="15">
        <location>
            <begin position="353"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="17">
        <location>
            <begin position="598"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="16">
        <location>
            <begin position="691"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="13">
        <location>
            <begin position="822"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP43970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="954" mass="102834" checksum="9D08CCC034AB0887" modified="2008-01-15" version="1">MPSQPVHAAAPAPNVSAAVSPKAAAPAAAPAPSHRAHPAARRRAYPTAHIAAHSMSYASTPDLAAAAASDAGQDSGVFTPAAVGHSPTRSVSSSMQTPSRTMPMRSVTQPSLSNIANAAPAASTQQPGMAGAVDTGSSIITPGLQGVPGVPGVPGVPGVVPTTGAPDIVQPMQNMSLGPGNARVGNQLLNAVVGAQPPIMTDLEGPPPPIMLPPNATVTPSVRANADPSYQRCTLNAIPTTNSLLSKSKLPFAVVLSPMRTVRPEEGDEPVPVVTDSVIARCRRCRTYINPFVTFVDGGQRWKCCMCYITNEVPQLFDWDQETNQPADRWQRPELNSGVVEFIAPREYMVRPPQPPVYVFLVDVTYAAVASGMVSTMASTILASLDAIPNKDNRTKIALIGFDSQLHFFRLMPGSTEPSLLVVSDLDDVFLPQPSDLLVNLSESRDCVETLLRNFGNMQSNAAVTPSALGAALRAAHRLVSATGGKLEVFTSSLATTGPGALKMRDDKKLYGGPRESSLLSAQSSFYKSLSIECSRNQVSVDMWLFGPSYVDVATLSCLPRYTGGQTFFYPIMDPKHPEVSHKFAHELSSVLTSPMSFEAVLRMRATRGIRPTSFHGNFFVRSSDLLALPSVPTDQSYMIECEIDEPLHTTVAVLQSVVLHSTATGERRIRVITTAVPTTTNLSEVYASADQLAIAAFMANKAVEKSLHARLDDARAMIRTRIADIFTAYRTTMTNTRGGNAAHLTIASNLSLLPLLALGLLRNRSIRIGTQIPSDVRAYHQTLLTTLPVQRLIPFLLPVFYSLHNMPPDAGTIDMSTQCLIMPPRLNLTSERFERHGLYLIEDGMSVFLWLGRAAVPALTMDVFGAPDYASLQSGPIVLPELENSMSQRLRAILDRIVTLRRGPYLSLLYLVKEDGDPGMRLLALSRLVEDRYEQTSGYLQFLGQIRDKVNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXA4</accession>
    <name>A8PXA4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PI31 proteasome regulator C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731197.1">
        <property type="nucleotide sequence ID" value="XM_001731145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXA4"/>
    <dbReference type="STRING" id="425265.A8PXA4"/>
    <dbReference type="GeneID" id="5855504"/>
    <dbReference type="KEGG" id="mgl:MGL_1380"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1380"/>
    <dbReference type="InParanoid" id="A8PXA4"/>
    <dbReference type="OMA" id="HALATHH"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="5">
        <location>
            <begin position="206"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="311" mass="33936" checksum="9D7CC89546E35400" modified="2008-01-15" version="1">MSVPVDHVLGQVLLLSEAHSQEFRTPLDAVALLFHALATHHYGLSSENVPSGWRSSPDMHGWSYELRAEPLHTIHIAVVRLGSHAVVLASHANVVQEHCSTSECLLESLVHAATPSELICTRARDVYVSKERIESTLHAWTRDILHADANHNTSADVLSRGYLTKKDPNGTATDTDKATEHDTSSLSHTPSFPPVSRMPYDPRRLGDADRDPLAASPAACPFGTGSFQPPRLFPPQAPMHGDGMIMGPNHPLFHTPRPPPGVPNQPEIGFLPPGSVPPHARFDPVSPFDSHVRARNGEPDFDDFAPPHSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXK1</accession>
    <name>A8PXK1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitin synthase</fullName>
            <ecNumber evidence="3">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_1466</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731283.1">
        <property type="nucleotide sequence ID" value="XM_001731231.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXK1"/>
    <dbReference type="GeneID" id="5855590"/>
    <dbReference type="KEGG" id="mgl:MGL_1466"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1466"/>
    <dbReference type="InParanoid" id="A8PXK1"/>
    <dbReference type="OMA" id="DYWISIR"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9 14" id="KW-0518">Myosin</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="803"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1454"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1491"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1519"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="16">
        <location>
            <begin position="47"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="17">
        <location>
            <begin position="1737"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP44069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1797" mass="203320" checksum="220E186FE71AAC54" modified="2008-01-15" version="1">MATTSTPDLAALFAHDEGKVRDAEITQVLCDRLDVSAPYTWASPTMLVATNPYFDTSQMDQEAAEAASVHAHVPSLQPHPYSLAARVYHKMLRTKRSQAIQYHGITDAGKTHTMQRVTEHLLALSASHSQRESSIADQIQCAQHILQAFGQAKTAINHQASRHATYWELHFSTHGRLAGGKVLVWGLDKHRLHDLDVNERSYAIFYQLLAGASRKERTEYRLDDVALGSAVPTREDARSFEWTRRAFATLGLKEKHVQGVLRVLSAILHLQGIEFGIWNNQVTVTTPEVLTRSADILQVSASDLQQSLVMDTQYIKNERLTRIMDVDGARRQRDTLIQNMYAVLFSFLVELMNQKLVPRSPSPLHVVQFDPPGFLSRGQLLDGQEHQGILSDYAHAFHAVLDGERTEEDDAALFRDLEAHNEHRAFIASRLPNGTYSFDINHALGACSYSVVSHQRSELDLLPTQQLQTLRASRAAFIARLFAGPGLAVESRLTDQQIVLRAQVSSCPLRRATRLGRVRVTWPETRIAGVMQQMDAIVLALFQTMQQADTCWHVFCLRSMDLVKLSVFDKRRVSSQVHALGLPRLVRAKQHGYIRIPLDEFQERFGEVEHVAGMYSWACPADYAVGTSNVYVSYNVWFSLDGHVGPIHAEHAPVPTVHVSPAEAQQSEPTEQYAYRDSMQDRQGMMPLMSTSAALDSETSLLKKDESFMDEPRESNGDVPLLGATTARPATSSWQDEAGLRNEMQMSGMDPIELEEEPVTPMRKWWVRLTWAITWWMPDSVLSHVLKKKRPDVRMAWREKVTICTLIFLFCALILFYIIGLGRILCPNFDRAWNEGQLSEHDGGKSFYVAIAGEVYDKPKFYKLDHSDIPSRPVTNDVMMELAGKDLTPYFPVPLNLGCRGLVSDASLELTPNENLTAQIPQAIHKSGSAQTNNNTKLNNQNWYYHTFLPRMKSYHKGAYVYDTKALEEDGSWRNWAVVDETVYDLTNYLNTQQRNPGVDAYSFLPSDIVDLFEAQAGSDITNDFRRAMDKLNGNTRQQTQHCLDQVFRVGQKDFRTEPQCVVQNYLLLSFSISLFFARFLGKSFISCSPIWRIDHRRSSRIVSLFAILPCYTEGEESLRKTIESITTQEYDDKRKLLFIVCDGMIVGGGNEQPTPRIVLDILGVDRQVDPEPLPFKSVANGSKQLNYGKVYSGLFECEGHVVPFIVVVKVGRPSERSRPGNRGKRDTQIMLMRYLNRVHFDTPMFPLELELYHHMKHVIGIDPFMYEFILMVDADTSIEPDGLNRLVAAAVDDPRTIAVCGETLLDNEGTTFWTMIQVYEYYISHNLAKAFESLFGSVTCLPGCFSMYRLRSSDKGRPLFISDKIIDDYSETKIDTLHKMNLFALGEDRYLTTLLLKHFPLYCTKFRSDAQALTSAPDSFSVLLSQRRRWINSTVHNLVELVRMKGLCGFCLFSMRFIVFIDLVGTIILPATAVYMVYLIVTVATGNGPIPIIAIAMIGAVYGLQAIIFLLKRQWQYIGWMIIYLIAFPIYAFLLPIYSFWHMDDFSWGNTRIVVGEKGNKKVVAGTDDEPYHDSMIPRKTVTEYQQELYANEQPLTNEMLLYDMMPPSKSMAHSSFTPNTELDMYADDYFQHTNLLDAKRKRQSNRQSLGSAMWMPTPSYGHESSSMLHSMFAPSLPMYSMTPLGPMYGSGMPPPMFPAPPSDWRTSMMSTGIPGGSVSEQHLSASSLPMDYSENPTDEQIRAQIRTYLATQPSLMQVTKRNVRDAVATSMPNADIQSKKALINRMIDDMLSGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXK3</accession>
    <name>A8PXK3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731284.1">
        <property type="nucleotide sequence ID" value="XM_001731232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXK3"/>
    <dbReference type="FunCoup" id="A8PXK3">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXK3"/>
    <dbReference type="GeneID" id="5855591"/>
    <dbReference type="KEGG" id="mgl:MGL_1467"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1467"/>
    <dbReference type="InParanoid" id="A8PXK3"/>
    <dbReference type="OMA" id="RYQNWDW"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="336" mass="37262" checksum="9168B03C776C8DCC" modified="2008-01-15" version="1">MPIDTPACFLYVNEPCIVVGRNQNLWNEVDPHAMRANHVPVVRRLSGGGAVYHDSGNMNFSFHTSKTNFVRATHTDLITRALSAPPIALPSRFGRAPVFRTERNDLAVLDVGATDASDAYVRKVSGSAYKLANRRAYHHGTLLLAADLQRMSMLKQRRTHIESKAVASVPSPVANLVDTFPAHAQRLTWPNLVDAIHAEFERTYGSSKRIDVDNSFLDAQASDGRRDVCVRTRYEEMRGWDWLYGSSPPFTVRVSTQDVPFSDVDDVHVAVSLHLSCVHGIIEHVDVCSSDTRVAEAAHALAGAPYDTVACAPPSCVLPRNWNIDNRLREWLARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXQ3</accession>
    <name>A8PXQ3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731317.1">
        <property type="nucleotide sequence ID" value="XM_001731265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXQ3"/>
    <dbReference type="STRING" id="425265.A8PXQ3"/>
    <dbReference type="GeneID" id="5855624"/>
    <dbReference type="KEGG" id="mgl:MGL_1500"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1500"/>
    <dbReference type="InParanoid" id="A8PXQ3"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13648" checksum="13C46911B25FA2F5" modified="2008-01-15" version="1">MCGTWNAEYLTSVQKAPDIRVGTATSFLNSSMTVDVSDMQTTATTVMTRSFAKKTAKLGSLLEVQDSEDPEGLRVMYYLVQDLKVRRTVFRRRDRTDMMMPQCLIFSLISLHFKIKPISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXT2</accession>
    <name>A8PXT2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1519</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731336.1">
        <property type="nucleotide sequence ID" value="XM_001731284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXT2"/>
    <dbReference type="FunCoup" id="A8PXT2">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXT2"/>
    <dbReference type="GeneID" id="5855643"/>
    <dbReference type="KEGG" id="mgl:MGL_1519"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1519"/>
    <dbReference type="InParanoid" id="A8PXT2"/>
    <dbReference type="OMA" id="RFNFIGN"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="427"/>
            <end position="429"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="518" mass="56888" checksum="DCDBD8F1D762BD67" modified="2008-01-15" version="1">MLASPTLRVAASLVANAPPMRVAIVGSGPSGFYAAARLLQSFDAKHGTGTDGTEIHMYERLPTPFGLVRYGVAPDHPEVRNVESKFDQVARDPRFSFFGNVRVTADDAPPPQSASTAQISLSSLAPFYTHVLFAYGASDARHLHVPGSSPGELEHVHTALDFVQWYNGHPDAHLPDAPFSKMSGSDIRHVSVIGAGNVAIDVARILLRQCKSTPLDASLQRTDAPESVLEQLRSWDVETVHLYARRSAAQLAFTNKELREMLNLPHVAFEPMNHETLDEALADVSRSSHTAYKRAMTRLLKQLQKGSVLPFDARHKPQWGIKLMHSPKEFTGSHGSKRVTHATWDLTEVRDGRAVSTGRTETTSTDLVLASVGYRSQPLAGSHGSFSVPFDSKQHIIPNERRRVVREDGSRIPGMYVSGWLATGPVGVIVSTMLDAFGVADDMLADWRQPDSLKHTLCASVGVNEAQLSVPTALHKQGKRIVSYSDWLRIDAAERERGLALGKPREKFLRVDEMLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY88</accession>
    <name>A8PY88_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ERT1/acuK family PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1614</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731431.1">
        <property type="nucleotide sequence ID" value="XM_001731379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY88"/>
    <dbReference type="STRING" id="425265.A8PY88"/>
    <dbReference type="GeneID" id="5855738"/>
    <dbReference type="KEGG" id="mgl:MGL_1614"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1614"/>
    <dbReference type="InParanoid" id="A8PY88"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ERT1/acuK family PAS" evidence="9">
        <location>
            <begin position="302"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="412" mass="46210" checksum="90CC5D8B2C774295" modified="2008-01-15" version="1">MAPSHYVQSDPGSHLPTDTSNHVSWGNEPASLESSILTSMIHDLDSAKPRADSPDGPSIPAMDLMESYTHISNMTSGDDAPGESSLAGAYHAVPAPQSNLFGTPGQSTFSPLTFMNAPSNVHMSDPPMLGKDGITPVAAAASSSFGTHTTLPTPNNHNHIHTSHHGQHHQQPRPQQQQQPLSSDSQSMNPTSSSLPQPRPGMPYRPESELQVEQLWKQRVSKVYRDNTRPFPYTEGYHILLKYATQKYEKADVLRIVRALAIYRPSLIALQMPLSEEDEIFVERAFQRTILEFEKLISFSGTPTVVWRRTCEIALVGAEFCMLTQWSKEDLLGKYIYQFMDKESVLNYWEMFASHAFENTTQSVMTKCVLLSPSNKSIPCTWCFTIKRDPFDLPGFVVGNVRYCQWQMTRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYB5</accession>
    <name>A8PYB5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731446.1">
        <property type="nucleotide sequence ID" value="XM_001731394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYB5"/>
    <dbReference type="STRING" id="425265.A8PYB5"/>
    <dbReference type="GeneID" id="5855753"/>
    <dbReference type="KEGG" id="mgl:MGL_1629"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1629"/>
    <dbReference type="InParanoid" id="A8PYB5"/>
    <dbReference type="OMA" id="NYLAQGH"/>
    <dbReference type="OrthoDB" id="3359121at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="2">
        <location>
            <begin position="802"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1166" mass="128432" checksum="108789A6B3093997" modified="2008-01-15" version="1">MAPEPIVYGRRRLEADAELSSEHSSSPSFQIVSPPFAQLGKDTGGGGDSSYDTSVASVPPPKGAIQDQLETDVESDMEEPVWPSFVARMQKKKTPSNTDALFLSDDEPQYEAASRSTTIQPNGMQGKLMPLPVSPRAEARTARMGKLRGLAQQRAAHHAQLSEQEPPEHVHMQASTSNATNSPSNRPSRPPTVLSHQRLYTENPSMPLDAGIHSDVSDDELDEEIRVPAPSKGPRGLSRKDQREMHSMSAKLRRENRTRLVRPEPKRYQLSELLSTIEHTASPTSIHAMNSSDPVESSSTPDARHALVPPQPSTSPSDAHARTKKKWEWIQRQKKGSVNDGTREDASGSDSDLEVIALGPHPPRPVPFSMSSPRDRQRDAADHALAHLAVYPRTPRRQRISTNEYRSPNAGEPHTSPVPDRQLDAMAHTFGFAANQQAGTLPAHTAATLHHSHPHQSRPFPSGLGLDELNATVLQKVYAQNAELTAKKDPHLKSDEQGTVPASLQTPAPAQAQVQSTLSPTPTPPVSPPAAALDDRSLFPSPSPSPPHLPPSPPLARPESRASVQSDDNSEKENVPPPAMRKPSSQSRTLSQHAPLTELPVSDLGDYFVPTQVPAQGSIPRTESNSSVLAQFFERGTQEPQQSGSLDIFANDRRSGPVGGMTQFFEATPAGSSMSRSQEAMPPPSRTYSGADADAFDALRRAERAAAAAPQSPDMFPSLDPSLAEHGEEVWREAQRAQKARHNEVLYLNEDGFFTQTKPTDETPSLFVHDHSGGSESDNHEDNDKDLVRKPAKSPLSQHRRRPQSAFVFGEAEESDEDEDEARGEHGGLAGIFSDEESLSNGRDGTKRGGNDDDGDDDSDADADLSSLLDDESDQDVDMKDDAVHQKYLQDRQNDDAALQAMHERATKGLFRHRRRGRNDDDRLADLLDEDADEDELRRRLQAPRFSKRKRRCIEGDGMDALAVRDDAQAFVKTYAETHTAGDDHAKYDFLDAGDVSSDEERVTAHDVRIQLLAQRAKDREQVINNEMRTRPMRDDEAIDKLDHTQHNMPIRLKSRSSELKPAAGAGATPGSDDDGDVRVLFKSGKVDEAALPRAVQEKRAQLLEEYSHEPQWHDVRGGRGQLDRRRTRQAKRPHSDPLAHRAWQATPSAPSVLKQHILRREARFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYH5</accession>
    <name>A8PYH5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:transcription coactivator activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:chromatin remodeling"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
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            <begin position="1"/>
            <end position="27"/>
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        <location>
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            <end position="519"/>
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            <end position="63"/>
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            <end position="280"/>
        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51293"/>
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    </evidence>
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            <dbReference type="EMBL" id="EDP44266.1"/>
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            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="61346" checksum="B4A7B9057B0F10F3" modified="2008-01-15" version="1">MDIADHIGNRTKEEVEKHFVDVYIKGKNGLPSGDRRAEKAVADWRESHPPDPSFHGEERLPIVGPDANFTTDVTMDEFQRARRERIEKLRASQLPIVPPKGGKPLVSAPTTHSELSGFMPGRLEFEQEFEQDAEHAVKDMEFGLVYSFGGDTLPTESEALNGKTATQGKPRMESSGRGGPVHVSTKVQDEPEEETFADALDSQAEPMSIDGKNEEPLPAANQSQSQSQMQHVRDSSHTAAEPVKLEDETRADTKAAAPAPQAEPASKSDEMHEDASPDWEEDPMDLELKLAILDIYSEQLNRRSRKKQFLFERNLVDYRRNTAAERRRPKEERDLLARIKHFATLQTATDFEELYQDLCYEEALKKTVRQLQHYRSLGITTLAEAARYDREHAERTKRQLEAAEGTLPSQAGRARHRERSQSVLDKKDTDEFSFATAPSIQLLTREEQQLCSLLHILPQPFLILKTVLLTYCFAHHRDLTIRHCERLCSIDPRKLAYIYDFFREKGYFHAVAQARTWEESQAPNASMTTPSHAVHEAVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZC6</accession>
    <name>A8PZC6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001730857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZC6"/>
    <dbReference type="GeneID" id="5855216"/>
    <dbReference type="KEGG" id="mgl:MGL_1908"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1908"/>
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    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="157"/>
        </location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="340" mass="37491" checksum="06BF635684F2AAC4" modified="2008-01-15" version="1">MAEEPISAAAALIAVNEDERQLHHTETEVDVFARNIEDRVSNLMGGLSTWFNGMNMQTQNAMLSAQEHVQQNGGVMSTARAHLSNLESQLQLHSDRARSKSRSSAEPMPDDAVFELDTKDEEEILEREKPTRSASVSSDAGNQSDAATSPPTSNLSHNSLWDVLRKVTAHPNVDRLQNTWKKNTTSDIPIQWQHTLKEAESLARAYARSSGAAMQNVSKDLQAKIQNVVKNPPTDENTPRTTDKSAMQPVHVVEDEDDFRWDDDDDDADNMPADERGMPSLQTSKPASERKETEATGPQSEPKESVKAKSNSPATGVTKISLSTNESRPSVDDDADSDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0A2</accession>
    <name>A8Q0A2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001730952.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0A2"/>
    <dbReference type="GeneID" id="5855311"/>
    <dbReference type="KEGG" id="mgl:MGL_2003"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2003"/>
    <dbReference type="InParanoid" id="A8Q0A2"/>
    <dbReference type="OMA" id="RNWNGIN"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="2" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1062"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1087"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1178"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1201"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1256"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1282"/>
            <end position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1331" mass="142889" checksum="8875C3073C217B60" modified="2008-01-15" version="1">MFSSHASVNGGNIYGSKTSIQKSRRDTSMPPSTHDAAADGAPVTPSSSRQREGFLHSIGSALYRTLPWVSKSKKSRSDSENEPLPVKAAAASTTYQSHPSHIPPKSSTLSPASSLHTSLKSSSTNQKPASWSVREIHSNSPTIYRPTPRAKWGTLDLGPPTTPSLSSHSRPQEILSAAGISSSTNSTTSVLGKRGEPVEDGQIEEESTYVPSARKRRMVWDPEMGFVDTEDLASRRPPPPPPQNEAERILRALESMRTPLGDARRDKLIRSQSLPSWHSTSIPIPLPMPQREGVLLEFRKPAFRTISPHTRSLHRSQRLRRSQAAHQPTMRSKLQESIRSSDTLFQPSAAVHLDDDSTYDEPEEPMRRPKRQTQLNQKKSRAKLVRTATKKIGIPARDTDAYSEPDNGHRAEHEATPMSDAHLISDAKPKIPMAKRNKFEVQKNEGSRSSRSVLRQGSAKTTRRHAPSSGRITAFDDEEEEDPMPSSEELSKIKLPSSMFPSDFRFDKKMGTKNEYPSEKSGDDLHSFAHKDDKGAITTTPAKEPAPGSVRFDLNSTTSKKHVEPSLFFSSAPSSASDNNSLSTTKNSGPIPDFFGTSRKDTRQPSRSASQLSVVSAFSTKPNLASDAKEDGGMKKRERDNEEPPSKKPMPSANKEDLGAKPSFSFEQPVGKKDQKPAFSFGQPTEKKDEKPAFSFGQTAEKKDEKPAFSFGQPAEKKDEKPTFSFGQPTEKKDEKPAFSFGQPTEKKDEKPAFSFGQPAEKKDDKPAFSFGQPAEKKDDKPAFSFGQPAEKKDEKPAFSFGQTTEKKDEKPAFSFGQPAEKKNEKPAFSFGQPTEKKDEKPTFSFGQPTEKKDEKPAFSFGQPAEKKDQKPAFSFGQPTEKKDEKPAFSFGQTAEKKDEKPAFSFGQTTEKKDEKPAFSFGQPAEKKDDQPAFSFGQPAEKKNEKPAFSFGQPTEKKDEKPTFSFGQPTEKKDEKPAFSFGQPAEKKDDKPAFSFGQPAEKKDDKPAFSFGQPAEKKDEKPAFSFGQTTEKKDEKPAFSFGQPAEKKDEKPAFSFGTSADTGSSSPSFSFGTSPSNVGGKSFGQPVDSQTSASTFSFGSAPNSGATTQNPPAFSFGASTPAFSIGKDVKSSTNSAPSSAPLFSFGASTAAAPAPVPPSAPAASPFTFGQPSATSTPPVSFGSSASSVPSFGANSASMAPTTSFSFGAPAAAPAPTTSFSFGSAPPSGAFQFGAGAPAAPASNGGGIAPTTSFSFGAAAQPGPTAAPSFTFGSGGTNSPASGSPAPFTFGTPPPSSTDSAGAGGGGLFNMGTSPATAGRQIKPLRQSRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0H6</accession>
    <name>A8Q0H6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731035.1">
        <property type="nucleotide sequence ID" value="XM_001730983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0H6"/>
    <dbReference type="FunCoup" id="A8Q0H6">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0H6"/>
    <dbReference type="GeneID" id="5855342"/>
    <dbReference type="KEGG" id="mgl:MGL_2034"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2034"/>
    <dbReference type="InParanoid" id="A8Q0H6"/>
    <dbReference type="OMA" id="PPMISIH"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="276"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="458"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="560" mass="60600" checksum="43F311A4AE613F1D" modified="2008-01-15" version="1">MSAMASAGDGGDTAMPPVDSSTAGEASPADPCFTSASARRFDRRLATLKNHHLHSLHAIRHFLRTHSSYDVLPVSFRLVVLDTQLSIKSAIDVMFQSGVVSAPLWRSTLNEDTLDTSKRPGFAGMITVNDIIHLIQYYHYTAANYDTAKLDVETLRLERLREIEHALNVPPPPLLWIGPLSPLTEAGELLVRTHARRLPLLDYNEDLRVESVLSVLTQYRLLKFIAMNCRETSGLKASIGSLGIGTYTYAHQLERKQRTPHARLRMQSETPPPPDAGPFWPLLTATLDTTVFDVVHMFSDNGISAVPIIDDEGDVVDIYESVDVMTLLRTGAYYQLDLTIRQALERRPADYAGIVCCSSDDSLASIFTVLKQRRMHRMLIIDPVCTESEPPTPNTSTESLVEENVASIPLCPKSRLVGVLSLCDVLRYIIGQPTQPVDVTPLPGSTSDAHFPPSISHTASVSASVSASASAPTSSTTTSMTSSTNTSTPMPSSSSSTTSPSPDMGSVMKTGTDTDTDAESGANAQTFVPSMMNRSPSESSGSSVATTTYAGHIPQTTPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0X7</accession>
    <name>A8Q0X7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731097.1">
        <property type="nucleotide sequence ID" value="XM_001731045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0X7"/>
    <dbReference type="FunCoup" id="A8Q0X7">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0X7"/>
    <dbReference type="GeneID" id="5855404"/>
    <dbReference type="KEGG" id="mgl:MGL_2096"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2096"/>
    <dbReference type="InParanoid" id="A8Q0X7"/>
    <dbReference type="OMA" id="PWMERRT"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="65"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="423" mass="47510" checksum="7F179E379BC198D6" modified="2008-01-15" version="1">MVPDRAQLKEAGYFAPERHDEAYLCRFLRARKWDFEAAKEMLFEAEAWRRQNKVDELYENFSFPEKEAVNELYPQFYHKTDKDGRPVYIEQLGNLDLNKLFKVTTPERLIQQLIYEYEKCLNERMPVCSELHHKLVETSCTIMDLKNVGIGQFWKVSTYVQQASKIGQYYYPETMGRFYIINSPYIFTTVWAVIKNWLDPVTRDKIQILGSNYIGELAKQIPLEEIPSIVGGKCQCPGGCLMSDAGPWNTPEGKEIVRRYQTEKRRLKSEYYGTNEEPQPCSPAKPTPHALGTETPQAQVSQNATAEQNMMVSAPAMLSRSKTVDEPTDEQMHQQQPSSSPVVADATSYPQAKTHDASQSFEVHPSVITGMDSVSSAALTESVTEHVSGNTGGIPSPAPSLSVQGTDGLAPPITSNALAPPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q113</accession>
    <name>A8Q113_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Arginase</fullName>
            <ecNumber evidence="2 12">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2111</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 12">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 12"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731112.1">
        <property type="nucleotide sequence ID" value="XM_001731060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q113"/>
    <dbReference type="FunCoup" id="A8Q113">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q113"/>
    <dbReference type="GeneID" id="5855419"/>
    <dbReference type="KEGG" id="mgl:MGL_2111"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2111"/>
    <dbReference type="InParanoid" id="A8Q113"/>
    <dbReference type="OMA" id="YKEFRYA"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000012">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="318" mass="34556" checksum="FE35FCB6834A974E" modified="2008-01-15" version="1">MSFHSQILKSPSTVMIPVPFSGGQPRKGVEHGPEALMKAGLQNQLETLGWKFEQEQAIPWDQINSMDEKNDGAKIMNAHSVSKASQHVADAVEKHAKAGKLPLTVGGDHSLGTGTMIGTARVYPDVACIWVDAHADINTAQTTPSGNLHGCPVSFALGLDGSYIEPFKQWIPEPTKNVHNRIVYIGLRDIDEGERKILKEHKIKAFTMHHVDKFGIGKVVEMALDHINGDTSRRDRPIHLSFDVDAMDPSVAPSTGTPVRGGLTFREGHYICEAIAETGSLVAMDMVEVNPHLEKHAAEQTIAVGCSLIRTALGETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q147</accession>
    <name>A8Q147_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731126.1">
        <property type="nucleotide sequence ID" value="XM_001731074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q147"/>
    <dbReference type="GeneID" id="5855433"/>
    <dbReference type="KEGG" id="mgl:MGL_2125"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2125"/>
    <dbReference type="InParanoid" id="A8Q147"/>
    <dbReference type="OMA" id="YSGEIYW"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728024" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="95"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="383" mass="42259" checksum="297EBA5645E719BE" modified="2008-01-15" version="1">MFRSFKVVALLAIAFSHAFASVYAGYTLELKRDSGSMKHNPDNHKALMDSIVAKYTKNAMNYHRNTGKHARSVNASKLMKRSGNTASLDMLRWNWNVELEFGSNRQKLYVKFDTGSSDVVMDGRGYDPSSSSTSEDQHTTFNANYVSANAGGKVYKDVIAMAGIQAKDVTISVSNDDFLTMNKDAGIVGLSWPLLSSYNSSEPTFYEAFQRQKLLKSNVYQFTLKADSTSYLDVGQIDTSKFSGSLGWVNVSPSDGYWSTDIGINGNDCSGIIDTGTTIIVAGNDKLKNLLSKLDGVTVKQDDDGNYQGWFNCNSPPEIKFSVAGKQFTMPEAIMKYQQSGNECRLPMNGMDGFSDWIFGTPFMEMASVVFDFDNARLGFASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q186</accession>
    <name>A8Q186_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730751.1">
        <property type="nucleotide sequence ID" value="XM_001730699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q186"/>
    <dbReference type="STRING" id="425265.A8Q186"/>
    <dbReference type="GeneID" id="5855058"/>
    <dbReference type="KEGG" id="mgl:MGL_1750"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1750"/>
    <dbReference type="InParanoid" id="A8Q186"/>
    <dbReference type="OMA" id="TYCGQLN"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="165" mass="17732" checksum="E736E3EBE157A9E2" modified="2008-01-15" version="1">MELSSAIRLGHPIAFSLFIFFSLVVAIIASAVTADFNSNGGYDKTVTRDSTRFMVFTGWWSFLFGVIFLVLFLTGTGGVASSIAVHGVVLLITWIFWLCGSAALSNVVGNESCGNDDAVRNCNSLKAILAFGWIGWIELTALLAVICYLAFKAFRGGRGVQQGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q191</accession>
    <name>A8Q191_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730753.1">
        <property type="nucleotide sequence ID" value="XM_001730701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q191"/>
    <dbReference type="STRING" id="425265.A8Q191"/>
    <dbReference type="GeneID" id="5855060"/>
    <dbReference type="KEGG" id="mgl:MGL_1752"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1752"/>
    <dbReference type="InParanoid" id="A8Q191"/>
    <dbReference type="OMA" id="NITRPCE"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="5">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="154" mass="17288" checksum="B91D1A9E9C2DEC21" modified="2008-01-15" version="1">MFPFFFLFWSGSLASQNGMGYWGNPPIGAFIMLRVGKPKNARSKRALEKRESKEFEHAKTAIFVKGTKTSEKVNMALSELALLKKPDAVAFNKRNDVLPFEDASSIEFWGQKNDASLFVVGSSQKKRPDNLCWVRLFDGQVLDILEMGVLHATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1W5</accession>
    <name>A8Q1W5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730850.1">
        <property type="nucleotide sequence ID" value="XM_001730798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1W5"/>
    <dbReference type="STRING" id="425265.A8Q1W5"/>
    <dbReference type="GeneID" id="5855157"/>
    <dbReference type="KEGG" id="mgl:MGL_1849"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1849"/>
    <dbReference type="InParanoid" id="A8Q1W5"/>
    <dbReference type="OMA" id="NWCARID"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="576" mass="63702" checksum="C34DB800721A0AC8" modified="2008-01-15" version="1">MDFTSTYSYASWDSVVFSPGSTFLAYVSGRSRTQVFVRVVGTLQVVRSWQLDARLDALEWSKDGLYLLASAYGLEKGVSFVLPLDPDVAVTDGSDDDRGWVARITAVHGLLYATWLPLRRIPAVIQFAPFHTGAVIYSLADQALTVLPATVLPCVFSHAMWPEHFATVQRHKEQDYLCLYTPHQTNAPSLEQPVEWNLWRAVRLHTNEISGAAWSPDGSIFAVWEHMLEYKLFAYTIFGTPQAAVTMQEDLIPHVAVPISAAECRATLTSPTDSGRARRVPVFSSTASASRMSSMSTSLTKHRSSYSGDPKHLKTHGLGVRVVAWHPSSEFLAVGAYDDHVHILSRYDWSLVYLLDTNVASLRDASPASLSVWQEPYRWFEATNGRGIVPLNFSMTIPVDVPLQPSQAHEPLQSGTCWMAWNQDGSLLALRNELTPSVVLLYEFVGIEERSVDAHIRAIAVIILSSPITSIMWRLGHLSSLALVTGQSSVICWTMNMSDHTQCCEAVAIPNEHFSATHIACSPDGKTMLLADARTFCCVVSAPNYDGNDDDLNEQRKTEVSQGATDDQDKMNLGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1X8</accession>
    <name>A8Q1X8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730856.1">
        <property type="nucleotide sequence ID" value="XM_001730804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1X8"/>
    <dbReference type="GeneID" id="5855163"/>
    <dbReference type="KEGG" id="mgl:MGL_1855"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1855"/>
    <dbReference type="InParanoid" id="A8Q1X8"/>
    <dbReference type="OrthoDB" id="3365211at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="851"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="889"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="986" mass="110826" checksum="98AB6E271E5403E7" modified="2008-01-15" version="1">MSPSDSFFPPPTLRIQRNPSSKTNALDNSLLRSKSQPSAAESGASNTTRRRGKSVVEGRDHEVRRETNVIVDDIAQPRFMSHPYENANDPTSSSSSRPAGGNTSGPSRLDLNRLFSRSNTTTNNAAIEDGEQCDTTSEPTLLPSQRVSGGGKDIVRESLKEPPAPPYSEFGPGTLDEGPYMAQSSSSPANFNFFRKGNGTPTDIANMNGLLSPSSRSQNDIPLIHIDKNEGGESLPQSHVVFMDNNYADHDTYDDDNKDIDTTRDISDMAYDASFLPENPVPDNQHTSGSILGSIVPRITSLWPGSHQDESDSRHHADEQLRHQQSPHPQLAEYEVVGNSNGMSRSGSRNGAGTPNRKTPREEQHPAVLHSDEMVDYLDVLDPAVGFFNTLQDYGNSAMLPNLPWLYNRRPTLRLNQVVPQNEIQRLKEEQTPMSPDSFDLKRGNASTSFRPAAAAGDETLLQPPPLTLPPADPVETPSSQPQPHPSDAVVVNMPDEYVNERERANSDGTFGNWSTDRDSLSRKDTSETVEAVPSSGAGKGSMRTDAKENDDPHTERYWAMDKEEREELEAHVRYLLTRKSKTRRMLRGFVNFVCTPMGFILTTYIFLIFSWGVVIFLLIVNWVHVEPYHRRRVWIEVCDQVLCALFVLRGVGFMPFRMVDTYHMAHIAHLHFLTYRRRRLLHLPELQNKNELPRYTRDRLESVTGPNSAPERTPGSGRKRSRRTRSRDERDSEEAATANASKDMELQDPVRDLESIGVKNVDHVRTQPYHFEQLLRPLPGLPGSTHQTVEEIEKARLKRTPSIQSWVEKNTHEVSVLTPSEQAQLQHHQHCFHSSHTFYRYRETATHRPFPLWLMMTIVVLLDVYSFLQACLAGTTWGIRYEHRPTALTATIISCSLSCNAIAGILIWQGGKRTRKTEVVQRRVKLALEEQAIQRMDRKRRKAARLAESGLMSGQKDRRSTILDVGDMANCKIEAATSDVADVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q251</accession>
    <name>A8Q251_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730682.1">
        <property type="nucleotide sequence ID" value="XM_001730630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q251"/>
    <dbReference type="FunCoup" id="A8Q251">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q251"/>
    <dbReference type="GeneID" id="5854998"/>
    <dbReference type="KEGG" id="mgl:MGL_2136"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2136"/>
    <dbReference type="InParanoid" id="A8Q251"/>
    <dbReference type="OMA" id="NEGTHFQ"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="8">
        <location>
            <begin position="73"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="325" mass="35393" checksum="576CCEA53E341414" modified="2008-01-15" version="1">MSNRTPHNVLKNMQRMFQQMQENASRAAGQGAQRGGGYNGHGGGGGQGGGPMNPAVGGAGIIALAGLALGINASLFNVDGGHRAIKYSRVYGVRDMIFNEGTHLLIPWFETPIDYDVRAKPRSIASLTGTKDLQMVSLTCRVLSRPSIENLPTIYRELGTDYDERVLPSIVNEVLKSVVAQFNASQLITQREMVSRLVRENLTLRARRFNIILDDVSITHISFSPEFTHAVEAKQITQQAALRAAFQVDQALQEKQAIIVRSAGEARAAELIGDAVRKNKGFLELKRLDAARDIATTLSTSGNRIMLDSQSLLLNVNDKSTVAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q283</accession>
    <name>A8Q283_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730711.1">
        <property type="nucleotide sequence ID" value="XM_001730659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q283"/>
    <dbReference type="GeneID" id="5855017"/>
    <dbReference type="KEGG" id="mgl:MGL_2165"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2165"/>
    <dbReference type="InParanoid" id="A8Q283"/>
    <dbReference type="OMA" id="PSYKPDY"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="580" mass="65094" checksum="FC04EE49D62C5A76" modified="2008-01-15" version="1">METPFDQLQYRQPEAAQAQYEQPQYEQAQYNGPEYEQSQFKRPENVQVPYEQPQFEQPHHRLHQMAQVPYDAPEYERSQYSRPRVEQAQYAQPQFRQPLIEQRQIDQLQYSQPAYGDRPQAPPSQPDFVYEPAPQQRNGMSSDVPYAYPSQYPSASKDQGMRTPQRAGPSLMHSPRMAPMPDEQMYTMGRQNMVQPMYPEDRFAAYGRSDLTLKMDHPPSQPEFGGVPTQQPPLSPQLLPGHVYPHDAYAQSAARGHAPVAHAHPTGYSSPYAKHAYPDFRGAQPPRRAEVPGPFAPQPQVYDSYGEPTPKAMGSGYDQSFMPPSDPRMYQSPVRSPLNMMQPHPFMQTATPPRIQTRPTSPSRQPSYGPMYMMEPNQPQGMHELPYGMPYDPQEPVYAPENSRYAYPPGMHSRYEQPSADYSAYSAPQHPLPHPHPHFAMPNQSMSSSWEPPQSSAASISSLQRMPGNGLIGTPRGKSGLPHPHQYESGSAYPSSSTSALYSPRPLDPDLPPEIPSFISATPQKLGTSRPLDQSTPQSPSSLPGDVFGGRRRKHKNKGASSSRSGWAALFQNDPLSAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2I8</accession>
    <name>A8Q2I8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730404.1">
        <property type="nucleotide sequence ID" value="XM_001730352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2I8"/>
    <dbReference type="FunCoup" id="A8Q2I8">
        <property type="interactions" value="439"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2I8"/>
    <dbReference type="GeneID" id="5854706"/>
    <dbReference type="KEGG" id="mgl:MGL_2199"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2199"/>
    <dbReference type="InParanoid" id="A8Q2I8"/>
    <dbReference type="OMA" id="EFHIFFV"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="708" mass="79282" checksum="9ABA0524C0ADEB4D" modified="2008-01-15" version="1">MADAGDAHRPRRTRHGLVDVAPLSQLAQDHFADVLNFIPDAKTLLIDPTLAGPLSLMVDLAALRQRGVEKMFWMEEVSVGLSPTRSVRIHAPTKQVLYLCRPEPRWMKTILAHYIADRDASGNDATLEFEYSVAFVPRRTEACVQFFRKHGCLQAINMFDLGLEFSVINPDVLSLEDPLAWRRLFLDGDHTPLFHAAHALMTLQRMWGVFPRIVGKGDLANRLCDLLLRQRREFLATDDEDGNARVRSNGTDPSMGTQVNPTRLHKPATDIDALVVLDRTVDLATPLLTQLTYEGLIDDVMGISSGFLNVDSSWVGAAQSAGSGASRRVRLDGNEDPLFESIRDDNFAIVGEKLHAAAKELSKDYEGRHQAQTVGELRAFVNRLGTLQSGHASLRLHTCITEHLLKTTSSERFHLLLEIQQHLVAGASLAPQLQAIDELIDLGVPMLDVLRVACLASYIHGGVKASWLDAFRTTMVHAYGFECLPQMMALERMRILYSSAATSSPSPTTARTSKWTHVLRPLRLIDDDVNERDPSDIGYVFSGYAPLSVRLVQTICQHEQTLRERQKRPHIYPKAARIAGWHGVDDAVLRWPGATFDFLPIKEAPTIPDDKIRTTVVFFVGGVTYAEIAALRLMSQQQQTRRFLIATTIHHKRERSFVQHESVISHGQPHILVHSSMVLPRDCKKMKRTSFPVKRSPMQGLWHHAGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2V7</accession>
    <name>A8Q2V7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730451.1">
        <property type="nucleotide sequence ID" value="XM_001730399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2V7"/>
    <dbReference type="STRING" id="425265.A8Q2V7"/>
    <dbReference type="GeneID" id="5854758"/>
    <dbReference type="KEGG" id="mgl:MGL_2247"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2247"/>
    <dbReference type="InParanoid" id="A8Q2V7"/>
    <dbReference type="OMA" id="IWQRMES"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="395" mass="43101" checksum="77A143E7DF00D4CD" modified="2008-01-15" version="1">MEPSAPVFLPREPFGRSHSTPAVSLMTTSGGRAALGERPVLAKQNTYLSCTLECTNDGHGIIAGGAYNDDRAIWQRMESSSALGSCTSDVDADINLHMDAASARVGAGADQEDDEERTLRRLAHRRLQRVRERKRAVSHDEVKRPVSDARLVMQEHRERRWSQSLQRKPSMRLEWAADRDLLLADKENVKPSMQHVEHAPAGSMQALAPQQPTRSRSSPHTQALAHTPAHPLTRVSPQHAAPPPPPPPPPHVPLSVSFVPPSQGRNVHATTAPTNRGTGMSVNASLGHRPLTRRAISASTSSTTTSPISTKPTTTWTRTSSTRSSDMMPATAKDDVPHDDSGFFKDGDRSDSFSPPTRAQPQHVLNTHDKDTWTEHDHQAAELLLGLGSASRIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q371</accession>
    <name>A8Q371_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730529.1">
        <property type="nucleotide sequence ID" value="XM_001730477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q371"/>
    <dbReference type="STRING" id="425265.A8Q371"/>
    <dbReference type="GeneID" id="5854836"/>
    <dbReference type="KEGG" id="mgl:MGL_2325"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2325"/>
    <dbReference type="InParanoid" id="A8Q371"/>
    <dbReference type="OMA" id="CATPATW"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="178" mass="19760" checksum="9FBB9EEEE9899A8F" modified="2008-01-15" version="1">MSVDAGCEFRGYASDITRTMPTSADGRFTSPQRDLYEALLRTLKGCTALATARQGYTLSALHRRSVEMLHAELRDLGFHLGFGTLERILYPHYIGHWLGIDLHDTSTIERSTRLQEGMVLTIEPGIYVPDDPAYPKAFRGLGMRVEDDVAVGYEDNLVLSAEAPKEVADIEAVCAQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q387</accession>
    <name>A8Q387_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730539.1">
        <property type="nucleotide sequence ID" value="XM_001730487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q387"/>
    <dbReference type="STRING" id="425265.A8Q387"/>
    <dbReference type="GeneID" id="5854846"/>
    <dbReference type="KEGG" id="mgl:MGL_2335"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2335"/>
    <dbReference type="InParanoid" id="A8Q387"/>
    <dbReference type="OMA" id="IDWHIRE"/>
    <dbReference type="OrthoDB" id="2554293at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="637" mass="72462" checksum="21E54245947CA601" modified="2008-01-15" version="1">MPALALRVRNLRACLKILSDSTRTDTSNSYLPPSLRHTLTATVLSLSKELRNAHIPPSDSFWQEVVDMFLGTVQRLSPRDGIYVYSRLAWLRPPLNPATRRRAHLIGIRLLVKASRADAKMPRTCVQHAWFGLKVLGQPTPKNTTPLIRSMILMNRLSDAVMILSWHIIGYWEHGKPPLSRSIMHHLMIQMCVVDRVLRSRPPRAPGRFVSSSSLLSEYLMALSSLSHLLVEMYIPLVPANKDDIVWLIKALSNVEPLLRRNQHERKLNRSLRNALPKWLESLPCGRPLPPNDVESVINDDRNRGSISEPSRHCKEDRAMYFIPPLSAHAYNTLIDYALKRARKPEWCRAILDHMTRQRSPPLTPDSITINILLKQSTHWRIPSLGTYALELGSGGDVVSISQDTPSHISTPRLLSHLDEALYGQDYHRICAIVHHIRDGQLRCPSNVHGIRATSVVLRLYPELRRARSRPGPLVARHPLVYAAAIRLANEAGQVQLALRVWRLGKHACISDRLPVAPSMAAAFMHVLIAAAMRSKRAHIRHGRVRNPQVLQARIAALQEYTWILQHNQDIGESQPMAMYAPLLRLLQLTGRTSAGKDAAYRRVCKDVHAMQPQRLPKQLQKILKPRTRHQYLRRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3E5</accession>
    <name>A8Q3E5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2373</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730577.1">
        <property type="nucleotide sequence ID" value="XM_001730525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3E5"/>
    <dbReference type="FunCoup" id="A8Q3E5">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3E5"/>
    <dbReference type="GeneID" id="5854884"/>
    <dbReference type="KEGG" id="mgl:MGL_2373"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2373"/>
    <dbReference type="InParanoid" id="A8Q3E5"/>
    <dbReference type="OMA" id="HFWAIGW"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="298" mass="31864" checksum="2BD54F212630A7B7" modified="2008-01-15" version="1">MGYSLCPAAYATTTALSPVVRLLALAGGITLCSTAANTLNQIVEAPYDAQMARTKARPLPRRAISPVHAFGVASCSTLGGIALLWTLTNPLTAALGALNVVLYSFVYTPMKRHSIANTWVGAVVGALPPLMGWASCTGTLTHTTDAAGWILAGILFAWQFPHFNSLSHAMGNEYARGGYRMMAVTNPALNRRVAFRYALSLLPLCSIALPITGTVLPIPYAVLSLVPNLLFAYYTGRFWHTPNEKSARMCFWFSLFHLPAVMLLAMACKAEMWDSILATFSGTLPSSTTSPSSPAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3G7</accession>
    <name>A8Q3G7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730599.1">
        <property type="nucleotide sequence ID" value="XM_001730547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3G7"/>
    <dbReference type="STRING" id="425265.A8Q3G7"/>
    <dbReference type="GeneID" id="5854906"/>
    <dbReference type="KEGG" id="mgl:MGL_2395"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2395"/>
    <dbReference type="InParanoid" id="A8Q3G7"/>
    <dbReference type="OMA" id="STHTIMN"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peroxin/Ferlin" evidence="5">
        <location>
            <begin position="117"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="6">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="334" mass="37501" checksum="CA7727E37AF423CF" modified="2008-01-15" version="1">MTGFVQTHVRPFAVQLGMWLSSTHTIMNIQMWPPFPIASLTVRHVLMITGVIVLTWCSPWATLLRMAVWRSAFVRRHVMSLVRVLSGSESLAASLYTTTVTPQPKPERAGPPKTSHETAFVFEIYENQRWWIGLDWTAALLPHERPSWSDSDNEAVAPPASFSLPAGTCVMMPSSRFPGKDDCRKSEWRWVDSEWHVAGVQTITSNSYKPASSVAPSEAQKVSKELSDKTTAAADNIQKEQTTEAVAQVEEAAHNARDTSVETVPDEVKRYARHATEPGVSMDVDAEGWQYGDNAWDKLSKQSGMGRYTRRRRWLRMAVLVESVEYGVQRCSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3K0</accession>
    <name>A8Q3K0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2428</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730632.1">
        <property type="nucleotide sequence ID" value="XM_001730580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3K0"/>
    <dbReference type="STRING" id="425265.A8Q3K0"/>
    <dbReference type="GeneID" id="5854939"/>
    <dbReference type="KEGG" id="mgl:MGL_2428"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2428"/>
    <dbReference type="InParanoid" id="A8Q3K0"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="13">
        <location>
            <begin position="91"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="373" mass="41536" checksum="553FC1C7D215407D" modified="2008-01-15" version="1">MAPSAAPAPGLAQATRRPDVNGTANPISPAMMPCTRLTNKSTGRAGASFTSSSLTPQTTSEQIAVDEEEVMFEFMSQAQAKQTKKALVRLQTNFGDLLLELYANKAPRTCYNFLMLCRQGKYNNTIFHRNIPGFMIQGGDPTGTGRGGESIWGKPFADELVNPGAYRHTSRGIVSMANKGYNTNGSQFFITYRATPHLDTKHTVFGHLISDDNDTKYPVLDALERVPNEPDSTKPIRPIKLIEAQVFEDPFAEYMAREEAKMRRQNPDEEERLRRETKRRKREEDRTTWYVLARMWINRLTHYRLGTRLAPKNMDAASSTATVPSAPLRVEPQDEHGLAALAGLKPSSKTGPPPRQSPGMAVRRGGFGDFSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3N2</accession>
    <name>A8Q3N2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2454</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730658.1">
        <property type="nucleotide sequence ID" value="XM_001730606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3N2"/>
    <dbReference type="FunCoup" id="A8Q3N2">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3N2"/>
    <dbReference type="GeneID" id="5854965"/>
    <dbReference type="KEGG" id="mgl:MGL_2454"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2454"/>
    <dbReference type="InParanoid" id="A8Q3N2"/>
    <dbReference type="OMA" id="NISAWHN"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="11">
        <location>
            <begin position="697"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="776" mass="86016" checksum="6327694EEBD718DB" modified="2008-01-15" version="1">MPDTAKGLPKIHHVPFAGSDNFPHSPPYLHSPNTTGRGVWAEPVERARNALAKLSMDDMVKIVTGTGFGNGLCVGNIGPVKKIGFPGLCVHDSPTGPRGVDLVTVFPPAITVGATFSKDLMYARAQAIGDEFRTKGIHVHLGPMVNVMRAPSAGRNWEGFGADPYLNGEGAHHHVRGIQSQGVQATVKHYTANEQEHFRNTGSSNVDERTEREIYMHPFMRGAFAGAAAFMTAYNLVNNSWSSQSSLLINQRLKTELGFQGYIMTDWGAHHSGVASALAGLDMSMPGDAHCCQELHTNSSFWGPNLTHAVSNGSVPEWRVRDMATRVLAGYYLVGQDKDFPKTNFNFWDINDPMTNAHVDATKNHSIIARDVVNAGTVLLKNKNETLPLKKPRKIAIVGSDASPFPLGPNYWDDRIGWPYGALGEGWGSGSVEYSYLISPYEALQARARKNNTGVNWSFDDFNHENAKKVANYTDVALVFVTSLSGEGFGSVPKSHPQNKSANMGDRNNLTLWNSGEQLIKSVASVNNNTVVIVHSVGPVLMEDWIEHPNVTAVLWANLPGSESGSSIVDVLYGDYNPSGRLPYTIAKERKHYPADVMYNSKIHQPQINFTEGLMVDYRWFDHKNISPRFEFGFGLSYTQFKYHNLDVAYVGDAKLKNWNDHWGHKNATTGLPSWLFKNAYNVTFQVENTGKFDGHEVPQLYVGFPKKSGEPPRVLRAFDRVWIPAGQNRTISHHLSHYDLSIWNTSTQQWLRPDGNIRLHVGASSRNLHLHKDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q421</accession>
    <name>A8Q421_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2489</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730107.1">
        <property type="nucleotide sequence ID" value="XM_001730055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q421"/>
    <dbReference type="FunCoup" id="A8Q421">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q421"/>
    <dbReference type="GeneID" id="5854414"/>
    <dbReference type="KEGG" id="mgl:MGL_2489"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2489"/>
    <dbReference type="InParanoid" id="A8Q421"/>
    <dbReference type="OMA" id="PQPLPCW"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725105" description="dolichyl-phosphate beta-glucosyltransferase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="113"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="393" mass="43679" checksum="579D8F6CE931838B" modified="2008-01-15" version="1">MALLLGAVIMYVALILATPKEVQMTAAECTYITAEEPNDPTPLPRLTEEPTVQLTVVVPMYNEAKRLGSMLDDALTWLESVRKSGEPLAQPAPQALPNYVTTPAAEAAAPLTQPLRTYEVLLVDDGSQDRTCEVAMTYAHEHPLAPGAEVRLTRMHYNRGKGAAVRHGVMHARGAFILFADADGATRFSDLAKVAREMSRILTPMGQGIVVGSRAHLVTSEAVVKRSFLRNLLMRCFHVILSVLMRPPSIATIWPRVVPSGAKVQRLPQQPEILDTQCGFKLFSRATAQLLFPLAHIDRWIFDVELLLLAEMACRVSEAQHVLRPESQRGDGHDTLLRLPLPISEVAVHWTEIDGSKIHLLSDSMRMGRDLIVIRLNYWLGRWRSPPSIYARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q497</accession>
    <name>A8Q497_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730132.1">
        <property type="nucleotide sequence ID" value="XM_001730080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q497"/>
    <dbReference type="FunCoup" id="A8Q497">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q497"/>
    <dbReference type="GeneID" id="5854439"/>
    <dbReference type="KEGG" id="mgl:MGL_2514"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2514"/>
    <dbReference type="InParanoid" id="A8Q497"/>
    <dbReference type="OMA" id="TWGINAT"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="25"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="225"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="290"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="348"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="421"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="482" mass="51143" checksum="375DD2BEF55094BA" modified="2008-01-15" version="1">MGTLFATQEGLLAAKGDKSDIVARKLFVWGTGEAGQLSLGGPDDDNIHKLTKPKPFGNKGISADTDAGELGPGGPEVIAAGGMHSLLIDANGRILSCGSDDHGTLARQYRDSDESEDDFYYVLRPVEGISPSGKGVPSEQGKVRRFRATRVAASDGCSIALNADGELVSWGHFKDGEGKVCFADTDADNAPREQWTPVPVPSLEDVRFAQVVCGENHVLALTLDGRVYSWGLNSMSQLGRFANLYHVRARFLKRDPPASMLLTPEAIPELKNIVRLGCGLNTSFAVDADGRVFAWGLNTRGQTGTGLKKDKVTRPTRVKALDPHRVGGARVVQVAGGEFHTAFLLSNGDVWICGDGDEGKLGLPETHEAMSKSPSSSTNDPIEPVQLRTPVHVPMPGTDARAHIIGIAAGMRFTFALAKDGTLYSWGTTSDEAMGQPAETWGDDQSKSVPTPVPMPGEPGSWQIVSVATAGQHSLALAVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4I0</accession>
    <name>A8Q4I0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730162.1">
        <property type="nucleotide sequence ID" value="XM_001730110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4I0"/>
    <dbReference type="GeneID" id="5854469"/>
    <dbReference type="KEGG" id="mgl:MGL_2544"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2544"/>
    <dbReference type="InParanoid" id="A8Q4I0"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF40">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="60"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="326" mass="35987" checksum="1CA795AB6DC650AA" modified="2008-01-15" version="1">MKTGLPPFGGMNGSGLLLGRLPDGSWSAPSAILPNYYSAGFMFGVDVVDVCRSCKSKYTYIKIVLIINTDEMLKSFRTHKFAITAETITSSGPLGTPVAGGLEFTNKVAPIFTYVNSRGFYAGIEVTGQVFLDRFDENERVYYWPGIKAGDILDGKVKVPECAEPLIRALREAEYGVAQAGVLEKMEMMKNLPSSIYTENLERTLDSLQEGEHIQLPPTPEQLDAMEHAGYKDEYDEALEEQERQEIRSLPPPPIHPSAKKGQRNISGSTQSPKPPVIPAKHASRPSTEIKPAQPKGESQINSKNLENLQPTNTEDKNQQIENEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4R4</accession>
    <name>A8Q4R4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maf1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730233.1">
        <property type="nucleotide sequence ID" value="XM_001730181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4R4"/>
    <dbReference type="STRING" id="425265.A8Q4R4"/>
    <dbReference type="GeneID" id="5854538"/>
    <dbReference type="KEGG" id="mgl:MGL_2615"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2615"/>
    <dbReference type="InParanoid" id="A8Q4R4"/>
    <dbReference type="OMA" id="FVSVWSR"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="58932" checksum="91B6ED8EDCBB527B" modified="2008-01-15" version="1">MKYLEYPELEVLSRALTFEMSECRVFTRIEAYSCKAVNKEKRLFKSLESSYLLSASTSPPAYLDEALASPFGRLDQPSARKTLFLLIATLNGAFPDHDFSEVNPADFVRESSPTVVLNSLTSTLLSLRNGGGSPSSLGGSLDESPLLSSLARSPLASDPRPTSGGGLGTSASSTSPSARPTFASLPSVIDEIIHTADCEVYTFHPDMDSDPHASAEPDEEGGGDMYEMDPYDEGYSADQDQALGSHGARFAEGVGRDGGLSGGDHRDRVFSLNVRDSFGGTERTALSMAHESRMDLDTHLAADTPMFDEDMDTGTVASSSSLTTPTTFFSGASGLESPSLTVDEDDLAGAGAGLLWSTFAFFYNKRMKRILFVSVWSRKNSPLGTTPTMWSSPSLAPARITTEDVPALGSNTQSLHDRLSERSNESRPAVSTQSSTARPFRARRAAPYSVVERRTPHQSRGRSASSSPAPSALSPFPHVQVPHAGTKTLVPNASATGGAATRTPRTRSSSTYASLDAAMCSVSAPGPRALEPLSGLASSKQQHRRSDGAAHPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4S0</accession>
    <name>A8Q4S0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2621</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730239.1">
        <property type="nucleotide sequence ID" value="XM_001730187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4S0"/>
    <dbReference type="FunCoup" id="A8Q4S0">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4S0"/>
    <dbReference type="GeneID" id="5854544"/>
    <dbReference type="KEGG" id="mgl:MGL_2621"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2621"/>
    <dbReference type="InParanoid" id="A8Q4S0"/>
    <dbReference type="OMA" id="MKEVDQV"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17971">
        <property type="entry name" value="DEXHc_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044762">
        <property type="entry name" value="DHX8/Prp22_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="168"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="496"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="677"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="390"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1152" mass="129063" checksum="74D18C7984F0D806" modified="2008-01-15" version="1">MDDPLYKLEFLSLVSKIATELENHLGINDRVLAEFIISLHEQAGSLPAFQKKLDDVGAEFTAAFVENLDRLIVTLHPRKKKGTNSVDEAKHTPDTKLEQKAQMLPGLAIQDQAWEEPDYYRDEPSRRRRMHESLEEPQRRSRWDRVDGRASPPPSLPPSVPDEQPVLNKVYYGRVSGVKDFGAFVTLDGVAGRRDGLVHISALCSNTARGGNTGRISHPSDVVSRGDHVKVKVISIAGQRIGLSMRDVDQVTGRDLVPQPRGRMAMEHPPNFLTGANHEPLGGRSSVASRSVASTSSTATEERRGRGAKRLTSPERWEIKQLIASGVAKATDYPELMEEEHSTPASRLAGDDADEDIEIEVNEKEAPFLAGQTAASLELSPVKVVKAPDGSLNRAAQAGTSLAKERRELRQQEQNEEADKKSRDMSTGWLDPMAQASEKMFAQDVRGQSRIQQAQQQSEWKKHAFNKATTFGKITTLSMKEQRESLPIFKLREPLVQAIRDNQVLVIVGETGSGKTTQVTQYLAEEGFADHGKIGCTQPRRVAAVSVAKRVAEEVGCRIGQEVGYTIRFEDCTSPDTHIKYMTDGMLQRECLVDPDVKAYSVIMLDEAHERTIATDVLFGLLKKALKRRPDLKLIVTSATLDAEKFSTYFFECPIFTIPGRTYPVEILYTKEPEPDYLDASLITVMQIHLSEPPGDILVFLTGQEEIDTSCEILYERMRALGPSVPELIILPVYSALPSEMQSRIFEPAPPGARKVVLATNIAETSVTIDGVYYVVDPGFVKQNAYDARLGMDSLVVTPISQAQARQRAGRAGRTGPGKCYRLYTEAAFRNEMLPNPIPDIQRQNLASTILALKAMGINDLLHFDFMDPPPAQTMLTALESLYALSALDDEGLLTRLGRKMADFPMDPPMAKMLIASVDMGCSEEMLSIVAMLSIPNVFYRPKDKQAQADAKRAKFFQPEGDHLTLLTVYNAWVSSRFSMPWCMDNFIQGRALRRAQDVRKQLVGIMDRYHHDILSCGPNYTRIRRAICSGYFRNAAKRDPQEGYRTLAESGGNVYLHPSSSLFHRPPEYVVYHEVVMTSKEYMREVTAIEPKWLVEVAPRFFRMADQANMSKRKRQEKIQPLFDKYAKDQDDWRLSKQQRVARVLQSQTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q558</accession>
    <name>A8Q558_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730347.1">
        <property type="nucleotide sequence ID" value="XM_001730295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q558"/>
    <dbReference type="FunCoup" id="A8Q558">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q558"/>
    <dbReference type="GeneID" id="5854652"/>
    <dbReference type="KEGG" id="mgl:MGL_2729"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2729"/>
    <dbReference type="InParanoid" id="A8Q558"/>
    <dbReference type="OMA" id="PRIFCNS"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="218" mass="24163" checksum="E764EFB538F992A0" modified="2008-01-15" version="1">MDELSEIGDEEGVYEDSLKIPDISIVESSAELLYGLIHQRYIITRQGMQQMVEKFEQGHFGVCPRIFCNSQFTLPCGRSDLPGLDTVKLFCPNCLDIYTPPSSRFHGIDGAFFGTTFPHLLLQSYRDLAPSILAPTNPSSQTSEDSPGSSMDISATSKEENATNSTKTLSLALLGRKVPQTGIYTPRIYGFRVSAFAPSGPRMQWMRMRPHSLSELST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5H4</accession>
    <name>A8Q5H4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729792.1">
        <property type="nucleotide sequence ID" value="XM_001729740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5H4"/>
    <dbReference type="GeneID" id="5854111"/>
    <dbReference type="KEGG" id="mgl:MGL_2778"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2778"/>
    <dbReference type="InParanoid" id="A8Q5H4"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="322" mass="35593" checksum="352F546635AF63C3" modified="2008-01-15" version="1">MCDSPWSTTAIADMESQQVAGNEKPTFAHSDIFKAKSINLMKNHADVKVMSQLDPEEDDTGNVEYKFQILPTSKDRFDRLVTQLNWRLTEGGGTCVYELGVLDNGTLAGIPLEDMRKSLSNLCAMAQLLGAEAEIRRLMIIGTDHKNDSFLYVLSENDEAFKVLDLDEGLPDTQSTTGITIPNDSLKIRLDSLLNDGLFRLQPNAHNLHCGDTSANENERSSENLYAQSSAYNAQSVQTPLSGSKSKTPAQQNKLHRRRVLRLGRFEAAIMTGAGKNLSEPSISNVSCSRVSVPPRVPTEEQLLAEVVIQLPNEFFIDYTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5I0</accession>
    <name>A8Q5I0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729794.1">
        <property type="nucleotide sequence ID" value="XM_001729742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5I0"/>
    <dbReference type="FunCoup" id="A8Q5I0">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5I0"/>
    <dbReference type="GeneID" id="5854114"/>
    <dbReference type="KEGG" id="mgl:MGL_2780"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2780"/>
    <dbReference type="InParanoid" id="A8Q5I0"/>
    <dbReference type="OMA" id="RAYVWIT"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31106" checksum="7A4E146FC93B494D" modified="2008-01-15" version="1">MLKASAPHLVWASGHFLTFVAGMRYWLATATLAWSGYDLWYRLAYIGAIVSYGVVIYKSFGVPRTDKSYVQRALMDENVQYLVIAMYWCWIKPISLTLIPYITFSLFHLLTFTRTTILPSIKPASQNADGTSTPAGGEMSKSIQKWVKQNYDVAMRFVSYAEVVIFVRVLIGAMLLRNSLLAPLFYAHFLRLRFYMSSFTRAALQHVRAELDQITQCSSCPPSVRKGYLMLTDLVTRYASTVLSINRNQPEASSAASSRPYASTSSPADPTKLKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q654</accession>
    <name>A8Q654_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2854</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729868.1">
        <property type="nucleotide sequence ID" value="XM_001729816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q654"/>
    <dbReference type="FunCoup" id="A8Q654">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q654"/>
    <dbReference type="GeneID" id="5854175"/>
    <dbReference type="KEGG" id="mgl:MGL_2854"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2854"/>
    <dbReference type="InParanoid" id="A8Q654"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="15"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="234" mass="25950" checksum="62429D221004AF19" modified="2008-01-15" version="1">MSTPIWRHALQVMSKRPIVLCGPSGVGKSTLIKRLFNEFPDSFGFSVSHTTRQIRPGEVQDKSYHFVSRAEFEQRVKNGEFLEHAEFGGNLYGTTAQAVRDVNGKGDGRRAILDIDAQGVRLIKENHPDLNPLFVFISPPTFATLQERLEGRATDTADAIDHRLRMALEELAFARMPGSFDCVIVNKDLDNAYAKLRAVVHDDLSGPFDQVPPEDDAEKLRRGSGPTGREGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q669</accession>
    <name>A8Q669_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_2865</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729879.1">
        <property type="nucleotide sequence ID" value="XM_001729827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q669"/>
    <dbReference type="FunCoup" id="A8Q669">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q669"/>
    <dbReference type="GeneID" id="5854186"/>
    <dbReference type="KEGG" id="mgl:MGL_2865"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2865"/>
    <dbReference type="InParanoid" id="A8Q669"/>
    <dbReference type="OMA" id="INQRDNW"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="172"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="402"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP42665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="532" mass="57605" checksum="955B8AF150F08B85" modified="2008-01-15" version="1">MPFLGKARRAVPAFATAVRNYATAKAAASEVSSILEQRISGATSNFDVEETGRVLAIGDGIARIYGLRNIMAEEMVEFSSGIRGMALNLEADNVGVTVFGSDSLIKEGDIVKRTGQIVDVPVGPELLGRVVDALGNPVDGKGPIQASERRRTQVKAPGILPRRSVHEPMQTGMKPVDAMVPIGRGQRELIIGDRQTGKTALALDAILNQRRWNDGNDDKKKLYCIYVAVGQKRSTVAQLVQTLEQNDALKYSVIVAATASDAAPLQYLAPFTGCSIGEWFRDNGKHALVVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMSEANGAGSLTALPIIETQGGDVSAFIPTNVISITDGQIFLESELFFKGIRPAVNVGLSVSRVGSAAQTKIYKAVAGSLKLYLAQYRELAAFAQFGSDLDASTRYTLNRGARLTELLKQRQYSPLAVEIQVPIIYAGIKGLLDEIPVDKIVAWETGYREELASQNDLLSEISKGVMTPEVEEKIANSIKASVSSFLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q785</accession>
    <name>A8Q785_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3313</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729769.1">
        <property type="nucleotide sequence ID" value="XM_001729717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q785"/>
    <dbReference type="STRING" id="425265.A8Q785"/>
    <dbReference type="GeneID" id="5854075"/>
    <dbReference type="KEGG" id="mgl:MGL_3313"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3313"/>
    <dbReference type="InParanoid" id="A8Q785"/>
    <dbReference type="OMA" id="WEAYMFT"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="14"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="294" mass="32475" checksum="F1762F065D8D5CCC" modified="2008-01-15" version="1">MRAAGGTSPLGPLPLTAIVAASLRNGIGSQGTLPWRLSKDMAYFRAVTMHVGEPVHDDEVMDSAGCVRTPVCMKNAVIMGRHTWDSIPPKFRPLRDRINVVVSTSMTRAHLGSSECDDHDTLIARSLDEAVALLQERRMWRYRARAEGDATLDSSDVLRGSALGHAFVIGGAALYRHLLTSTSQAWTLDSLLVTRIFTPVDLHEKCDVFLTEFRSPAQVAWEIERADTWTGRTPQPEKDALVCPNPDGLGAWQQATPEWHAHHYPCVLPALLGPILDDNGMAIQFQCWRRSTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7D0</accession>
    <name>A8Q7D0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="8">PME-1</shortName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3324</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729780.1">
        <property type="nucleotide sequence ID" value="XM_001729728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7D0"/>
    <dbReference type="FunCoup" id="A8Q7D0">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7D0"/>
    <dbReference type="ESTHER" id="malgo-a8q7d0">
        <property type="family name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="GeneID" id="5854086"/>
    <dbReference type="KEGG" id="mgl:MGL_3324"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3324"/>
    <dbReference type="InParanoid" id="A8Q7D0"/>
    <dbReference type="OMA" id="VMVCHHG"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120516">
        <property type="term" value="F:diacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="109"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="382" mass="42631" checksum="3879F3DD8B4E69D7" modified="2008-01-15" version="1">MPLPQDLRTSLLKRQYRPDAYDHGYNEEQEDDDEVGELPNVRAQQYHVPPARAPGAYAPLSCDDCFSSALEIDIPCIVSSPGDSEKHATIRAYFTPPCSGLTPSSTVMVCHHGAGFGALSFALMAKEVSRISKGELGVLAYDCRGHGKTTFPLEEKKNMSLEALTSDLLALLRTMFRDVNQRPSFLFVGHSMGGAVVVEAAHALEREHDIRVAGVAMIDIVEDTSLQLLPDMSRIVRQRPLGFASLESAIQWHIKTRTIRNAESARRSVPSLVHLMRGYRDLPWRWNAELIETEPYWTGWFKGLSSKFLACHAARLLILAETDRLDRTLMIGQMQGKYQLVVNPHAGHCVQEDDPTSTADTLFHFWRRNDKLPPGLRAVGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7S8</accession>
    <name>A8Q7S8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729564.1">
        <property type="nucleotide sequence ID" value="XM_001729512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7S8"/>
    <dbReference type="FunCoup" id="A8Q7S8">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7S8"/>
    <dbReference type="GeneID" id="5853870"/>
    <dbReference type="KEGG" id="mgl:MGL_3108"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3108"/>
    <dbReference type="InParanoid" id="A8Q7S8"/>
    <dbReference type="OMA" id="GMSLEMQ"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000052">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="68" mass="7637" checksum="9E18FA669D0B7831" modified="2008-01-15" version="1">MRMIEVIANDRLGRKVRVKCSPEDTVGDLKKLIAAQTGTAPHKSYSTFKDHITLADYEIHDGDSLELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q879</accession>
    <name>A8Q879_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729676.1">
        <property type="nucleotide sequence ID" value="XM_001729624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q879"/>
    <dbReference type="FunCoup" id="A8Q879">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q879"/>
    <dbReference type="GeneID" id="5853982"/>
    <dbReference type="KEGG" id="mgl:MGL_3220"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3220"/>
    <dbReference type="InParanoid" id="A8Q879"/>
    <dbReference type="OMA" id="HAIACAM"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="218" mass="23741" checksum="2F75FE80C6CB322F" modified="2008-01-15" version="1">MSTLSSFMGAILPALLTRRAAHWVSAILFIVFGVIALRQGLAMSGDEIDKEWKETQEEIQEDEDVHELTDLEQQAGDDSPGYPNIAPYPRTSPSVKEQASPSHFGVFLREGTRNLCGLMFSPVFSQAFILSFLGEWGDRSQITTMALASTHRVGIVAIGTSLAHMACIMLAVMAGAIFATRISPRHLTIGGAMIFLVFGLMAVYDAIYEPEPSAPLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8A2</accession>
    <name>A8Q8A2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">MGL_3233</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729689.1">
        <property type="nucleotide sequence ID" value="XM_001729637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8A2"/>
    <dbReference type="STRING" id="425265.A8Q8A2"/>
    <dbReference type="GeneID" id="5853995"/>
    <dbReference type="KEGG" id="mgl:MGL_3233"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3233"/>
    <dbReference type="InParanoid" id="A8Q8A2"/>
    <dbReference type="OMA" id="WATMLLH"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="623" mass="68100" checksum="A5A740F697441C4E" modified="2008-01-15" version="1">MDGSVRSALASLRAAYHAPEVQTTIQVSNQSAQERPARPGTIHESEFVPLRDTLIHQLEVSLFHAEQAQNLLGMLIQNTRTESASSSASSSVLAAQSDYFLDPHALSLSSLDRSWQTSSAAQGGAGVGINPAIDEDVANGGNIDDGDQAPPREKPSLSARKLVLQEKLSSLRSAAAILSQGAEEIQTCLPTERDRWHGLQRIQQRGWKLTPGRPLVDMERFDTTAKQDILHGFGVPILQGDGSVKEEGARDAWIGYGPSEAPIAVLQRTLAYWADAPQGAADTHKQHNRLAFPDRAWHRLQVQFHEQCTDGSSRVWVSAYSMNKNNACSEKEVTDMETDADPVLASDGQTDADVDLDAQLYEAQLDAVDTELFRELAAQSGTLSPVLSRSISEDCVRIPLSSSLTLCFVMVPFSRTDAPHCTTANENDVPMKEVSPWATMLLHVLRLRMLRGWTVHLANMRLSRVTSIAQRPLVPRSLLMAPLWELYEYTLFLNRLRAALEKSLACFADACMVWQPFGTMHDARMWIASLLDLTTNEPTKSGTCGGNVWVYHRSAIVAQLALRAPSYIMAYFPQHPTPGGVGIRMPVELESLVPFLESELATADKAILANSASPAPAPAPGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8K1</accession>
    <name>A8Q8K1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729741.1">
        <property type="nucleotide sequence ID" value="XM_001729689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8K1"/>
    <dbReference type="GeneID" id="5854047"/>
    <dbReference type="KEGG" id="mgl:MGL_3285"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3285"/>
    <dbReference type="InParanoid" id="A8Q8K1"/>
    <dbReference type="OrthoDB" id="3336711at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="134" mass="15601" checksum="3A7BE5DC95F286CC" modified="2008-01-15" version="1">MQLRSRNERNREFVIQRQLIVRVLEQLQNNRRQTLLNTSSICKQMILAGLKPSEFGFDSAEASDIESSMKSYHSDLSWYEAFFSQKSPTRQKVESHDFGDTQWEQGMVHTSAIELTHSDFLKILQELENSENSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8K7</accession>
    <name>A8Q8K7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_3288</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729744.1">
        <property type="nucleotide sequence ID" value="XM_001729692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8K7"/>
    <dbReference type="FunCoup" id="A8Q8K7">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8K7"/>
    <dbReference type="GeneID" id="5854050"/>
    <dbReference type="KEGG" id="mgl:MGL_3288"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3288"/>
    <dbReference type="InParanoid" id="A8Q8K7"/>
    <dbReference type="OMA" id="WYADGMY"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="249"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="635" mass="73003" checksum="1F9D18E5F2E14FD0" modified="2008-01-15" version="1">MDIAKAISKSLSERVVISKVNGILWDLERPLEGDATLELLDFEHPEGKRVFWHSSAHVLGEAAERHYGCHLCIGPPTDEGFYYEMGMGDSGDRPVKSEDFEPLEKLIGMAVKDKQPFERAVLTKEQLLEMFKYNKYKVHIINSKIPDGTSTTVYRCGPMIDLCVGPHIPHTGRIKAMTVLKNSASYFLGDQKNDSLQRLYGISFPDKKQMTEYKHFLAEAAKRDHRRIGREQELFMFHDLSPGSCFWLPHGARIYNTLQDFIKSEYRKRGFDEVISPNMYNSKLWETSGHWANYKDDMFVLSVDKETFALKPMNCPGHCLMFASRDRSYKELPLRFADFGVIHRNEASGALSGLTRVRRFVQDDAHIFCRASQIEDEMINCFDFLQTVYGHFGFSFKMELSTRPEKHLGDVETWDAAEKRLASALDRFVPGRWELNPGDGAFYGPKIDITISDAMRREHQCATIQLDFQLPQRFNLEYKTPQGGAEADKHTERPVMIHRAVVGSLERFIAILIENFAGKWPFWLSPRQVLVVPVTQSVYEYAEEVRALLWDRGFFADADLSDNTLNKKIRNGELAQYNFVFVVGHEEKETRSVNVRNRDNDPKVMKGKTDTIKLDDILAKLQKLKESRAIENQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q945</accession>
    <name>A8Q945_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729374.1">
        <property type="nucleotide sequence ID" value="XM_001729322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q945"/>
    <dbReference type="FunCoup" id="A8Q945">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q945"/>
    <dbReference type="GeneID" id="5853681"/>
    <dbReference type="KEGG" id="mgl:MGL_3409"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3409"/>
    <dbReference type="InParanoid" id="A8Q945"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="51"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="206" mass="22793" checksum="720F07C2033EE09A" modified="2008-01-15" version="1">MAKVGIPKDVAALAVPETGSVRLFGKWDAQDVEVKDISLTDYISLRNNVFTPHTAGRYAVKQFRKAQMPIVERLVNALMFHGRNNGKKLMAVRIVAHAFEIIHLLTDANPIQILVDAIINTGPREDSTRIGSQGTVRRQAVDVSPLRRVNQSLYLLTTGTRESAFRNVKSIAECLADELINAAKGSSNSFAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q984</accession>
    <name>A8Q984_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin/FtsZ 2-layer sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3432</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729397.1">
        <property type="nucleotide sequence ID" value="XM_001729345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q984"/>
    <dbReference type="STRING" id="425265.A8Q984"/>
    <dbReference type="GeneID" id="5853704"/>
    <dbReference type="KEGG" id="mgl:MGL_3432"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3432"/>
    <dbReference type="InParanoid" id="A8Q984"/>
    <dbReference type="OMA" id="ICRRNID"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="14"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="223" mass="25143" checksum="DC7C54705171D741" modified="2008-01-15" version="1">MSGCSTTLRFSGQLNSDLRKLGVNMVPFPRLHFFTCGYAPLVASSLQAYQALNVPQLVQQGFSPHNNMAAIDPRTGKYLTVAAIFRGCISSEEVESEMHKIQTKSTGGFVEWIPQNVLTSLCDVPPPKVKLSATFIGNTTSIQELFKRTHSQFGAMFRRKAFLHWYTNEGMDEMEFTEAESNLLDLVAEYEQYEAAGIDDDEVYEGEYVEEPYDEQGEFAQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9E2</accession>
    <name>A8Q9E2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729430.1">
        <property type="nucleotide sequence ID" value="XM_001729378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9E2"/>
    <dbReference type="STRING" id="425265.A8Q9E2"/>
    <dbReference type="GeneID" id="5853737"/>
    <dbReference type="KEGG" id="mgl:MGL_3465"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3465"/>
    <dbReference type="InParanoid" id="A8Q9E2"/>
    <dbReference type="OMA" id="KWAPLCV"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="422" mass="46587" checksum="87A9E862BFFBBBC3" modified="2008-01-15" version="1">MNAAPEKELGKFLGLDDATVSEQVLPIISSHKTPKALHAYLRDLIGSSPEAMSLTERFVHLHFPKEEESASRRDAKPIRLTPSTLKSALAEADQRAKPRHLEPTPEMKALDAELTMLSTEPSSANAFSYAPTQGYMCLCQGQQHELAKWAPLCVACGLVLCNALRPVPIAPTSICPSCQTSPIVSTKDRMRLLSEMAGLREHLAQEQAEQESRRHAEWTAQRLSGQLPEQAFPALNERPSSLARPTPTMQGKVPRSRTLHLDLKTHKVTVSNSRPKSSASASETSSTHTSKRNEGHSEDMPSTAEDGSPLIYNFDDDGFRFRFGNALSHQAIKSFGRHWSDVPASSITCTYMPSNTRDMPLPTFETEELTEVPELDSLLQRRPPGSASDSRHRNRQSATAEALSRSQGRKTGKPGRRRRPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA77</accession>
    <name>A8QA77_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729169.1">
        <property type="nucleotide sequence ID" value="XM_001729117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA77"/>
    <dbReference type="STRING" id="425265.A8QA77"/>
    <dbReference type="GeneID" id="5853475"/>
    <dbReference type="KEGG" id="mgl:MGL_3636"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3636"/>
    <dbReference type="InParanoid" id="A8QA77"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="233" mass="26654" checksum="2E51E38343356585" modified="2008-01-15" version="1">MAELDASTKSEEEAPLFLLSSQSTSEPSPSRLPAMHTKVEQNCGLGEPVKRRCQTEARVHQQPQPQPKYEQHQQCQPRRRQLPVDSPHKRRRKSDRPSRRLHASSWVLDEAERETDSEAHGESDEDDDGPSTSEENDDDRAAVGDFEPTQRTGYQQQAVYLQSMLSQQAPTPFRRRDRLVELLEKRYVTQPSSELEASSQHVDEYSQDSFVVDDDAISWASSTNESIESMYHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA87</accession>
    <name>A8QA87_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729179.1">
        <property type="nucleotide sequence ID" value="XM_001729127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA87"/>
    <dbReference type="STRING" id="425265.A8QA87"/>
    <dbReference type="GeneID" id="5853485"/>
    <dbReference type="KEGG" id="mgl:MGL_3646"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3646"/>
    <dbReference type="InParanoid" id="A8QA87"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="199" mass="22294" checksum="D2806E8C60201680" modified="2008-01-15" version="1">MPSQPQNDPGGVQALLAKLRSLQDRVTDTDPNQCTQSGHLRPWAVSSRPLPAYLRRSGVLASGTSNPLALSKQQQAAPRDVENEQAVKHTLMLCEDASFLKAFGKVRHCPVLMQLQTEQDALELALAKERTALVGKDEEHLRGPKYVIKPVILFSSMQLTKPSGARTQAAYAHWTWEALRRWNQLRYSQQQQLEQVCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAG5</accession>
    <name>A8QAG5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729257.1">
        <property type="nucleotide sequence ID" value="XM_001729205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAG5"/>
    <dbReference type="GeneID" id="5853563"/>
    <dbReference type="KEGG" id="mgl:MGL_3724"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3724"/>
    <dbReference type="InParanoid" id="A8QAG5"/>
    <dbReference type="OMA" id="EHATENS"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="807"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="837"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1001" mass="104771" checksum="48050BD016671FBC" modified="2008-01-15" version="1">MDPSQIETPPMSLPQANARPLLPETQPLNIGPAGRRHSDMASTMYASAPSPSFAQGMSNPVMQGAPMGMAIRPPMPTPMGPPMSSPMGSPVGSPMVSPMGPPMGPAMARPIAPAMRPPTGFPVGPPMGPPMGPPMGPTVGPPMGHPMARPMAPPTRPPMEASARAPTGPTAKSLMATGDAAKQPPAADIPTHAASAAPNTPAHTRDSPEFKRLEVIKVTPPNVKEARRSFGYSSEPPKPPSADPSSIFNPVEPTTEAPSGPQVVPPALPPRRSPPLRKRPDHDAAAQTPANAPPPADAADSALASERTPKATPTKLPSHHGQDWGVPDGPSAPWAVSESAWPHENQNESLLADVDTVEPVTSLPIGTSEPTSDKPSSVATDVLSSTSAPTEKMATPPEFPSNLPAVDTAEEAPMTGHDTLEPDRMSTRATEPIKNQSHEPTLRDLSEQGIVPERTHQDAASVKQTVMNESEMVSAPHVPVDLTGKESAPFTTNAPETEHVSEPSGLSANTHVPVHPVPGEKDVTVLPATQHGDVPLHKTVPEPVSVQDSVVQPGPSGVPVPESLAIHDTVAETALIDETVVQTTTMEDSVTEAPVPPTKSELESEPEPEPEPVPGEHTSVPLDSQIPPPLPEKSVQNSQPVQETVPVDTLATEALESEPLPKATHDAEASVSESLPSATQESANDVHPAQTQPPEPLHSLEHVSEPVPEHELATETLPDQEPLSDLLRSSSHADDTNATAAAAAAGVAGAALGAAAAATAAVTDSMPSKEEARIDTLSSVPPETEARDQVTLPESESQEKDPHMLDAPASSAAPAESGSKSTSPVGQTPVHVVVPISSEARSSSAASSTGIVPGSSGPSGASEPEIPLIQAPISLEHAMSMVKPCLIIEYCDRCRWLHRATWLQTELLLTFSEKAFLDDSCSQASGGGFIASTLLIPHATTDTAGQFRVWIVKSEGTRESTEVILIWDRKTRRGFPELRELKNLIRDRVAPKQNLGHSELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAI7</accession>
    <name>A8QAI7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729279.1">
        <property type="nucleotide sequence ID" value="XM_001729227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAI7"/>
    <dbReference type="STRING" id="425265.A8QAI7"/>
    <dbReference type="GeneID" id="5853585"/>
    <dbReference type="KEGG" id="mgl:MGL_3746"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3746"/>
    <dbReference type="InParanoid" id="A8QAI7"/>
    <dbReference type="OMA" id="GHNGIEA"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="6">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="137" mass="16055" checksum="BEAD3F395DF9FC46" modified="2008-01-15" version="1">MKGASDGGIFVPHNARRFPGYDVESKELDAEVLRNYIYGGHIAEFMESLEEEDDERFKKHFSSYLSDDIGSEDIEEIYEKAYEAIREDPDFKPTEKTKDWAAESKKYKQPKLTYEQRKARVQEKINALQDTFNLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAJ4</accession>
    <name>A8QAJ4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729286.1">
        <property type="nucleotide sequence ID" value="XM_001729234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAJ4"/>
    <dbReference type="FunCoup" id="A8QAJ4">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAJ4"/>
    <dbReference type="GeneID" id="5853592"/>
    <dbReference type="KEGG" id="mgl:MGL_3753"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3753"/>
    <dbReference type="InParanoid" id="A8QAJ4"/>
    <dbReference type="OMA" id="ITFYSWS"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="139" mass="15780" checksum="37E7767391DC14EF" modified="2008-01-15" version="1">MSSGVKVSQECLEQFQSLKLGKKTKYIIYTLSPDNTEIVVSKTSESPNYDDFLAELPPAECRYAIYDFEYQKGDEGKRNKICFFTWSPDESKVKQKMLYASSKDALRKALVGIATEIQGTDLSEVSYETVLEKVSRSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAM3</accession>
    <name>A8QAM3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728994.1">
        <property type="nucleotide sequence ID" value="XM_001728942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAM3"/>
    <dbReference type="STRING" id="425265.A8QAM3"/>
    <dbReference type="GeneID" id="5853301"/>
    <dbReference type="KEGG" id="mgl:MGL_3782"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3782"/>
    <dbReference type="InParanoid" id="A8QAM3"/>
    <dbReference type="OMA" id="RSANVHY"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="567"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="618" mass="62123" checksum="0EF5DC65BBC1316A" modified="2008-01-15" version="1">MDSGSPPPSYQETRAKSEEHHPPPHGPEDDGPPAKAHKHDANSYPGKLPATTSATTSAQPAQSAQPTTSSTSSMGQYNTIDFLGNVSGGPHAAAAEALATFSSSVGDTVNNNHIYVSVPSSSHVDANAAATGVPNAAHMPPTPTPPQPAAGAAVTAGPAPGAGTAAPPPSAAPQHGPPFLCPTCNTSYSRLEYLRRHERRHADIRPFSCPCGKSFSRSDVLARHKTKCRVVLSGEVQTSSPSDARPKAERAQRGNGSRSTRNRSAAATSTRGQAGPGAGVAAPRSDRHPMGDLSVDPALSGATAATGVATSAVDPSMQPPPPLETGAPDHHVDESYSYVNAPASFATHTQHMDSEYGPNRSANVHYAQAPPPPLPAPSSAAAHASGMPVRMHESKMYAPHGAASGPPRATNAAPPPPPSYVTGAPAIHPELSSRGSGMYNTSHAPTGAGGPGTSTAGPNVSNAFYAPQHNGAEHAGSAGSVNVNGSGANAGAYGAVPSTHYAEGNTTGAPAAGSQAGAPGNVYPHNKELARFSVASSGPLSPFSNTALSSNISPYLSAFSCARDMPRMSSPRLGGGASTASGTNGVPPATTTNAPATSHSPHQTDDAPPPPPPDANSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAQ6</accession>
    <name>A8QAQ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729023.1">
        <property type="nucleotide sequence ID" value="XM_001728971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAQ6"/>
    <dbReference type="FunCoup" id="A8QAQ6">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAQ6"/>
    <dbReference type="GeneID" id="5853330"/>
    <dbReference type="KEGG" id="mgl:MGL_3811"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3811"/>
    <dbReference type="InParanoid" id="A8QAQ6"/>
    <dbReference type="OMA" id="PCLSWED"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="43"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="367" mass="40300" checksum="A32BEC2A4F8E1D1E" modified="2008-01-15" version="1">MTEVTYANDTRVTGYEPLMSPSLLMHELPVSEKAKATIARGRDEAARVIRGEDDRLLVIVGPCSIHDVDQAKEYARRLHEAYEQRWKDGLVVVMRAYFEKPRTTVGWKGLINDPDLDGSYKINRGLRIARQLLLDLTEIGIPVACEVLDTISPQYLSDLYSWGAIGARTTESQLHRELVSGLSMPIGFKNSTDGGIGVAVDAIRASSQPHAFMGVTDQGMAAIVKTAGNQDLHIIHRGGKRGTNYDAESVATSKAELLKALSDKHPSIMIDVSHGNSNKDYRNQPKGSADIAAQIEQGQDAITGIMIESHIHEGKQSEPKNGSTRADLAYGVSITDGCVSFETTVDMLDQLYAAVLKRRQQKQQKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAX8</accession>
    <name>A8QAX8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729062.1">
        <property type="nucleotide sequence ID" value="XM_001729010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAX8"/>
    <dbReference type="STRING" id="425265.A8QAX8"/>
    <dbReference type="GeneID" id="5853369"/>
    <dbReference type="KEGG" id="mgl:MGL_3850"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3850"/>
    <dbReference type="InParanoid" id="A8QAX8"/>
    <dbReference type="OMA" id="WHLRESQ"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="1">
        <location>
            <begin position="74"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="278" mass="31621" checksum="01F9D1D5D91B1B0B" modified="2008-01-15" version="1">MWLQAEPTERARLPQPGTPEWTLFLAEVMEEAFSALRKVNVTLRWRTVQGQGKVTKESITSIHPAGHPLRRAHWHSRSSLHFPKELGLGFEAFEEGLLQHHTQHEQQYIEALEHAECLEVLVPQVAEIWHMKYRTPSVTANRDFVELVLMLPMPTDENPFNVFHEQETIKALKAGTLSLDTRSIPRGPPGTYRSFLVISMPIAHAATPNYVRGYYASVEGVREDWTIFRPGEVGVQWMLTTQAEAGGSIPRWLQELSMPSQIVADVPAFLEWAKLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB14</accession>
    <name>A8QB14_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729080.1">
        <property type="nucleotide sequence ID" value="XM_001729028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB14"/>
    <dbReference type="STRING" id="425265.A8QB14"/>
    <dbReference type="GeneID" id="5853387"/>
    <dbReference type="KEGG" id="mgl:MGL_3868"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3868"/>
    <dbReference type="InParanoid" id="A8QB14"/>
    <dbReference type="OMA" id="NSAHWER"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="246" mass="26918" checksum="84E78272E89536B9" modified="2008-01-15" version="1">MVKAHVRSPPNSKLISLYLFDAVARHAQEIVRRHGVGFISNIPSSELATNASTFLHALQDPAAQVGIDSLKHTPEEQREKVRKVIDIWDRAGTFSAKILQQIRDQTTSPNGASSKPVEDRGQVAPTSSGLPANVLELLGQVSQRQQGSLTTSVAPSAKDTPTSAPSSRRSEMSQAAFPQGGSFHDRNSFSSPEASASSSDTEAKNDLRAFDQASFDPTNSEHWERLSYLWKNTYKARCIYIHSLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBQ2</accession>
    <name>A8QBQ2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728937.1">
        <property type="nucleotide sequence ID" value="XM_001728885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBQ2"/>
    <dbReference type="STRING" id="425265.A8QBQ2"/>
    <dbReference type="GeneID" id="5853243"/>
    <dbReference type="KEGG" id="mgl:MGL_3931"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3931"/>
    <dbReference type="InParanoid" id="A8QBQ2"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="62" mass="6894" checksum="E3BE6BD88C4228FF" modified="2008-01-15" version="1">MQKHNLPYRLLCDPKRFLIGALTGTKSSTRRSHFVVDQNGKLTLSSVGVKPGEVRLITRTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDB7</accession>
    <name>A8QDB7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="5 16">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_4179</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="5 16"/>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728700.1">
        <property type="nucleotide sequence ID" value="XM_001728648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDB7"/>
    <dbReference type="FunCoup" id="A8QDB7">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDB7"/>
    <dbReference type="GeneID" id="5852987"/>
    <dbReference type="KEGG" id="mgl:MGL_4179"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4179"/>
    <dbReference type="InParanoid" id="A8QDB7"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000005">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000032">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP41486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="416" mass="44661" checksum="9BC2D96FBF73F7DA" modified="2008-01-15" version="1">MSLSTKLAITDVDLTDKRVLMRVDFNVPLDGEKITNNQRIVAALPTIKYALEHKAKAVILMSHLGRPDGQKQDKFSLKPVVPELSRLLNKDVQFVPDCVGAEVEQAVNAASGGAVVLLENVRFHIEEEGKGKNAQGEKIKADKDAVEQFRAGLTKLGDVYVNDAFGSAHRAHSSVVGVNLPQRASGFLMKKELDFFSKALESPERPFLAILGGAKISDKIQLIENMLDKVNMLIIGGGMAFTFKKVVNNMAIGNSLYDEEGAKKVNDLMAKAKQNNVEVFFPVDFVTADKFDKAAQVGTATDESGIPDGWMGLDVGEKSRQIFKDAVLKAKTILWNGPPGVFEFDNFAGGSKAVLDACLEAEKNGCNVIVGGGDTATVVAKYNAEDKISHVSTGGGASLELLEGKELPGVAGLSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDC0</accession>
    <name>A8QDC0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728702.1">
        <property type="nucleotide sequence ID" value="XM_001728650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDC0"/>
    <dbReference type="STRING" id="425265.A8QDC0"/>
    <dbReference type="GeneID" id="5852991"/>
    <dbReference type="KEGG" id="mgl:MGL_4181"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4181"/>
    <dbReference type="InParanoid" id="A8QDC0"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="219" mass="24280" checksum="2E1AF441BE9B2AF3" modified="2008-01-15" version="1">MDASGAIVPRSLQSSYAKLARPPTRDRPLHVVIACTGSVASVKIPLMVERLMNYANVHVFVVASAAALHFFQRDQIEAMDLSSQHFSVADLAEMNRTGIHAKSPRLRVWTDEHEWRAWKRVGDPVLHIELRRWADLVLVAPCSADTLAKLCHGLCDNVLTSFMRALSPSTPAWIFPAMNTLISKLSNRLGTRSMDPSPNASLAEMLARVRCLNGQILCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDE8</accession>
    <name>A8QDE8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_4196</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728717.1">
        <property type="nucleotide sequence ID" value="XM_001728665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDE8"/>
    <dbReference type="FunCoup" id="A8QDE8">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDE8"/>
    <dbReference type="GeneID" id="5853008"/>
    <dbReference type="KEGG" id="mgl:MGL_4196"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4196"/>
    <dbReference type="InParanoid" id="A8QDE8"/>
    <dbReference type="OMA" id="WAMSERG"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727321" description="Catalase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="46"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP41503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="712" mass="79814" checksum="5F5F45092F088979" modified="2008-01-15" version="1">MMAWKQVLLLALSFVVLASSAHNDNVTIHFRHGGDPQQHGGEGNLTTDQGVLISDNQNSLKAGTRGPTLLEDFVLREKIFNFDHERIPERIVHARGSGAHGYFEATEDISHLSRAHVFKKGMKTPVFARFSNVAGGSGSVDTPRDVRGFAVKFYTNEGNWDLVGNNMPVFFIQDAIKFPDLIHSVKMEADRGYPQAATAHDTFWDWATLMPESTHMQLWAMSERGLPRSLRMMEGFGIHTFQLVNESGDAHFVKFHWKPKLGVQSTLWDETTKIQGADNDYHRKDLFESIESGMYPEWQLGIQVFDKEFADSQPYDVLDSTKLIPEEDVPVKFIGRMVLNRNPDNFFAETEQVAFCPSHVVPGIDFSDDPLLQGRLFSYLDTQKSRLGTSNFHQLPINHPKVPVRNFQRDGMMQMSIPKGRANYEPNSLYEADEPTGPRACPFMAAFHTSSHVTGPRERGPKLRARDERFADHYSQARQYWKSLTESEQNHTVGGFVFELSQVSLSQVPKRAVANLRNVDESLARRVAKGLGIELPKKSKPVREPVDLPASPALSIHRNTKHTIEGRKIGILINEGSDKGKIERLKKMIKEHNGVPAVIAPRAHGIKLSDGSKVDADGILAGMPSVLFDAVAVVLSNKGTDQLLKESAAVQWVQDAYAHLKAIAYTKESERLLKKGGVDTNQKGISTDLGSEFIKDAGTRFWKREHLVRTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQX2</accession>
    <name>A8PQX2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732753.1">
        <property type="nucleotide sequence ID" value="XM_001732701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQX2"/>
    <dbReference type="FunCoup" id="A8PQX2">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQX2"/>
    <dbReference type="GeneID" id="5857059"/>
    <dbReference type="KEGG" id="mgl:MGL_0528"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0528"/>
    <dbReference type="InParanoid" id="A8PQX2"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="193" mass="21552" checksum="0D0F7D0B6F4226FF" modified="2008-01-15" version="1">MSLFVATRMLRAPLRTTEGLMRAMPFASRAIHTSSKAQALPWAKKAPVVPMTEEQDLKRLNTQRNERPISPHLSIYQPQLTWVSSILHRATGTGMSWALYAYAIGYLAAPHIGLGEMLSSGSLVDAVSHLPAWAKVSVKAPLAAAFMYHFFNGLRHLAWDMGYCTFLFSHVVANRLTTVQSRFSVRRILLVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQX3</accession>
    <name>A8PQX3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732754.1">
        <property type="nucleotide sequence ID" value="XM_001732702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQX3"/>
    <dbReference type="FunCoup" id="A8PQX3">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQX3"/>
    <dbReference type="GeneID" id="5857060"/>
    <dbReference type="KEGG" id="mgl:MGL_0529"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0529"/>
    <dbReference type="InParanoid" id="A8PQX3"/>
    <dbReference type="OMA" id="QNMSGDP"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="148"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="562"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="886" mass="102210" checksum="B764D8CDF9982382" modified="2008-01-15" version="1">MSAKQYDRYLRRLSAVQHSTRRVMRTSVDEEEDVNEENDNEVERIPIPELTPIARTPAPRRLPPMIRQLDRGHPNTLTHDPSAPVAESYLHEASFVLNPLSGRTPNVASRKLARSRAYHVDEPDQSTPSQHIVNLLSVDATLQDVLLVEDLLYVLIGIEGNYIQFSSDYKPDDLGHRLNGTRFVIDDSLNSSLRELVERMLPLSGYYTSISAFLECESGLEYGTVMHALCAAIRAQLKTYEELVAQMEERLLSSPDFTLQQLWLQMRPMLRTFSLIHSVTSEIASITHADVLPREDENDEEDDVDNEDGSSSSDAGFDSDASQLERDRRALLGMEDDFEQGIVGGIVKGGEVLSMLWDRLTHLGGDPLAHNLYLELFREASQPYARMLLRWITSGVLLDPYEEFMVVEDARVTRASLESDPTDEYWERRYMLRDERFYAQQEQQARDGDPMADDVDEARGELTGGAKIPAFLEPWKHKILLAGKYLNAIRECGIDVSNVLSDRVQTLFGSQDAHVESYLALDAKLERVVMDDESFAVCIERAYQRANAALLCLLKKDKDIIARLCSLKHYFFFAHADFLQTFLDQSEHELRKVVDPQRIRETTLMRLQTQLDMALGSSDTVGFLDPYREDLRVDLAKERAYDQLQRIADTKGVIEIAKLRAKQQAERQHQGTREVVMYLLQFDVHVQFPVSLVISKKNILRWQFIHRCLLLFKLLERALTDVWVDQTASSWRRRDRRPHAAPMERWKMRIHLLRQRMLLLVQQLLAFYTSEVLEPNWHDLECKLLEARSVDQFMKHHFDFLNTCRKECMLTDYRYLECHRKIMNTITAFTESKARFAEQYANMQTAVDAWYEQGDESAPAPQLIDDGDILVKIEASWNKHARVCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQY3</accession>
    <name>A8PQY3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732764.1">
        <property type="nucleotide sequence ID" value="XM_001732712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQY3"/>
    <dbReference type="FunCoup" id="A8PQY3">
        <property type="interactions" value="635"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQY3"/>
    <dbReference type="GeneID" id="5857070"/>
    <dbReference type="KEGG" id="mgl:MGL_0539"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0539"/>
    <dbReference type="InParanoid" id="A8PQY3"/>
    <dbReference type="OMA" id="VKYQEQQ"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="155"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="684" mass="75548" checksum="7F864CD5B322DE7C" modified="2008-01-15" version="1">MAPGLNLPPPTQGSSSEDLHLISTSKVDGEIFPTGGVVYPPPDLRPIIDKTAEFVARNGVAFEAKIREQERLNPKFAFLNSGDAYHTYFRLQIRAAAERKHDAPGPADKDRAASAVRAALLADKSNTAKKTEPERPLPHEFSLEFPSTAAVDLEVLKLTALFTARQGQGFASRLMARESRSYQFEFLHPKHPLFSYFHLMVEQYRSIMQPSKERIEHIQQCASRRRGPGAGGARMHVLDEVRKRATWTKWDEDRRQQEHDEEARQRALFDEIDWQDFCVVGVVEVTTNDASAELPPPRSLYEMQSMVLTHKKMSALHTAERSESNEQKTSTEASTPATSMADQHNATPAGSSHHGSAGADAEAAGPSSLPAHDTNTPTSTEGTRASVVRSTAQGPVKIRHDYVRGARPAPSTAPATTVCPVCGDTVAVNDMSEHVRIELLNPKFREQRAQMEQRRQEQASLAAGADPSHFLRQFAGARTDIFGVRADEEAQARREASERRLAREKEKNVWDGHLNSSKTAQDARARSGDIDQQLAQMRARPAPAATTATPIGPQVPSKRPTEEPLPPQPPSKRRADERREEGAPRYAEQEWLAMYPHPITLRVHVPDATHIAPACDGHVEETSGLSLSTTIGQVRDRILSETLGKAVGASKLKMWVQGKPATLRQSLAYWNLMDGAHVEMSLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR08</accession>
    <name>A8PR08_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0564</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732789.1">
        <property type="nucleotide sequence ID" value="XM_001732737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR08"/>
    <dbReference type="FunCoup" id="A8PR08">
        <property type="interactions" value="667"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR08"/>
    <dbReference type="GeneID" id="5857095"/>
    <dbReference type="KEGG" id="mgl:MGL_0564"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0564"/>
    <dbReference type="InParanoid" id="A8PR08"/>
    <dbReference type="OMA" id="MCGTVER"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="7">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="9">
        <location>
            <begin position="113"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="366" mass="40015" checksum="BB472C09F77C2B0A" modified="2008-01-15" version="1">MAAPSPSPFCIRGTFNLSTNKTQRAASSYTYKSGCSARYSQDARIPDHILEEDDEDDEQVILTMPGQGVAPSTQYMRGHGCYIDPSSSEIVSSMSGIVERVNKLISVRPIRTRYRAEVGDLVVGRIMEVQSRRWKVDIGTTTDASLQLSSVNLPGGVQRKKLESDELQMRMFFQEGDLVVAEVQSVFQDGSVGLHTRSLRYGKLRNGALAVIPPVLVRRHKSHFITLDKLPEHGIDLLLGLNGYVWVSKHIDFDVAKAEGEGGHHSVAAPPAMQVGANESVGLGGRGVAMDIDGVYSDVNEPISTETRRSITIVCIALAAFVHHGITVTESSLERACAWGIEQADLSDPITLAHSMIHMIRRHNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR96</accession>
    <name>A8PR96_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732226.1">
        <property type="nucleotide sequence ID" value="XM_001732174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR96"/>
    <dbReference type="SMR" id="A8PR96"/>
    <dbReference type="STRING" id="425265.A8PR96"/>
    <dbReference type="GeneID" id="5857167"/>
    <dbReference type="KEGG" id="mgl:MGL_0001"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0001"/>
    <dbReference type="InParanoid" id="A8PR96"/>
    <dbReference type="OMA" id="VNAVTPC"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08285">
        <property type="entry name" value="NADP_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF4">
        <property type="entry name" value="NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="17"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="360" mass="38430" checksum="24E072E91E4C2070" modified="2008-01-15" version="1">MSSIPGTMKGYAMIKIGETGWVEKPRPTCGPMDAILRPLAVAPCTSDTHTVWKGSIGERHNMVLGHEGCGVVEEVGSQVKDFKVGDRVMVAAVTPDWCSVEAQGGYSMHSGGMLSGCMYSNLKDGLLAEYVHVNQADANLAHLPKNISTAEACMLSDMVPTGFHGVELADVQFGDKVLVVGIGPVGLMSVAGCKLRGASQIIAVGSRPVCRETAKYYGATDIISYKEGPIDKHVLELTNGEGVDKAIVAGGGVETFEPVIKCLKPGGKVGNVNYLASGDYVNIPRVEWGVGMGHKQIVGGLMPGGRRRLEKLASLITYGRLDVKPLITHRFDGFEHMEDALLLMKDKPEDLIKPVVILSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRF4</accession>
    <name>A8PRF4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732265.1">
        <property type="nucleotide sequence ID" value="XM_001732213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRF4"/>
    <dbReference type="STRING" id="425265.A8PRF4"/>
    <dbReference type="GeneID" id="5856571"/>
    <dbReference type="KEGG" id="mgl:MGL_0040"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0040"/>
    <dbReference type="InParanoid" id="A8PRF4"/>
    <dbReference type="OMA" id="EQWETKY"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18843" checksum="2D2139A4F34DC9E3" modified="2008-01-15" version="1">MDRIKEKLNSLRAEADAALERAEVAEARNKELEQDNLSKEQEISSLQHKLSVLESDLENAEAKLSEAKVGKEEGESHKSNVDILQRRIDMLEEQLDQSERSLKETTEQLRHTDVRAEQLERQIQGAEQERDQWEHKYEEAQERYQASKRELDEVVQQMESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRV2</accession>
    <name>A8PRV2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732360.1">
        <property type="nucleotide sequence ID" value="XM_001732308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRV2"/>
    <dbReference type="STRING" id="425265.A8PRV2"/>
    <dbReference type="GeneID" id="5856666"/>
    <dbReference type="KEGG" id="mgl:MGL_0135"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0135"/>
    <dbReference type="InParanoid" id="A8PRV2"/>
    <dbReference type="OMA" id="ERCKIRW"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="146" mass="16320" checksum="F0630A34B2F590D0" modified="2008-01-15" version="1">MLMGRVSIVAIVTSKVSEEHTRSFYEAAYERFHTYPHFQLVQINLQENSLKAYLISLFLSSLRSQVAPKLQSTYLLSQQSLDMVREPMGLHNKHVGYTYLVGPDGKIRWAGSAFAEPDEARTLVACTGVLLDRMPGGRKAASRDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS83</accession>
    <name>A8PS83_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732436.1">
        <property type="nucleotide sequence ID" value="XM_001732384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS83"/>
    <dbReference type="STRING" id="425265.A8PS83"/>
    <dbReference type="GeneID" id="5856742"/>
    <dbReference type="KEGG" id="mgl:MGL_0211"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0211"/>
    <dbReference type="InParanoid" id="A8PS83"/>
    <dbReference type="OMA" id="AFAHSEC"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000009">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="3">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="120" mass="13621" checksum="1F808B8D74E73567" modified="2008-01-15" version="1">MHASGPRYDQDRLGIVFRATPRQSDIMIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDLYVPGCPPSAEALLYGILQLQRKIRRSRQAVLWYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSC8</accession>
    <name>A8PSC8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732459.1">
        <property type="nucleotide sequence ID" value="XM_001732407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSC8"/>
    <dbReference type="STRING" id="425265.A8PSC8"/>
    <dbReference type="GeneID" id="5856765"/>
    <dbReference type="KEGG" id="mgl:MGL_0234"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0234"/>
    <dbReference type="InParanoid" id="A8PSC8"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="3"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="389" mass="42035" checksum="67EB18F85EBCA98D" modified="2008-01-15" version="1">MRDALAGRGLWRDEWEMSGRVEAVVGDLARPRLGLSESDWHHMVTSVDIIVHNGAMVHWVYPYSKLRAVNVLSTIAVMHMAAEGRAKSVAFVSSTSALDTNHYIELADSTRGVPESDMLEGSAQQLKSGYGQTKWVAERLLMVASARGLAAAIVRPGYVVGDSTTAVTNTDDFLFRLVKGSAQLGLIPDMDNTINMVPVDHVARVTSLAALNAVAWPEQETTHATVFHVTSHPKIRYNEFLGALAKYGWPVQRVEYVEWRTALENHVMASTTHAPGSDTESNALFPLLHFVLDDLPTSTKSAELDDSHTTKLLSRAHELDVVRGVSQPLVGLYLSWLVAVGFLAPPPATGTRSVNEASAPSTANSPLLPLPSLPQGSVLQAMGRGSAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSD6</accession>
    <name>A8PSD6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM50A/XAP5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732463.1">
        <property type="nucleotide sequence ID" value="XM_001732411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSD6"/>
    <dbReference type="FunCoup" id="A8PSD6">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSD6"/>
    <dbReference type="GeneID" id="5856769"/>
    <dbReference type="KEGG" id="mgl:MGL_0238"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0238"/>
    <dbReference type="InParanoid" id="A8PSD6"/>
    <dbReference type="OMA" id="HKGGTVQ"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="152"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="292" mass="34361" checksum="922019C486CFFC00" modified="2008-01-15" version="1">MSAENTCLTNADKVGPSRFVARRESVDHSSELRPAGLVQPDKLQQQRRESTGTAEQDNERTNCNVANNKAKNKTNKTIKRKRAFNRLSFDFEEQGPHDEKPMIKRAMHEKPLKNPHVDTSFLPDREREASEHQMREKIKNVWHAEQDKIKAEEIEVVYSYWDGRGHRRHVTCQKGTTIFSFLELCRKQVPELRSVTSERLMYIKEDIIIPHHYTFYDLLVTRARGKSGPLFHFDVHEDVRLRNDASREKDESHAGKVVKRDWYEKHRDIFPANRWEVYDPTKEYGSYGIKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSI2</accession>
    <name>A8PSI2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydroorotase</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732487.1">
        <property type="nucleotide sequence ID" value="XM_001732435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSI2"/>
    <dbReference type="FunCoup" id="A8PSI2">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSI2"/>
    <dbReference type="GeneID" id="5856793"/>
    <dbReference type="KEGG" id="mgl:MGL_0262"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0262"/>
    <dbReference type="InParanoid" id="A8PSI2"/>
    <dbReference type="OMA" id="TLHHISM"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000071">
        <property type="entry name" value="Dihydroorotase, homodimeric type, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="372" mass="40579" checksum="7A0F52624F80199F" modified="2008-01-15" version="1">MDANTLTVPSPADFHVHLRQGPMSELVTPHVALGGMHLAYVMPNVTPPLTSAEQTVEYIAQLQKHAPHTRFLGTMYLSPSITPDEIRRAAAAGVRGVKSYPRGVTTNSDGGIENYEVYYPVFEAMQECHMVLNLHGEIPSDPESGVCVLNAEPLFLAHLEKIHANFPKLRIVLEHATTRAAVECVKRCGDTVACTITPHHLQLIVDDWAGKPLHFCKPVAKTPDDRAALRDVIREGHPRFFLGSDSAPHPIASKYPSPASRNNSTAEFVHQCGCAAGVYTSAVLLPLCATLLESFGALDKLAGYVSEHGRRFYNEPAEPGRVVKLRRTTPDDKPVPASYVHASCLGKDDGDPTKLQVSPFYGGQRLAWAIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSK6</accession>
    <name>A8PSK6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732499.1">
        <property type="nucleotide sequence ID" value="XM_001732447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSK6"/>
    <dbReference type="STRING" id="425265.A8PSK6"/>
    <dbReference type="GeneID" id="5856805"/>
    <dbReference type="KEGG" id="mgl:MGL_0274"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0274"/>
    <dbReference type="InParanoid" id="A8PSK6"/>
    <dbReference type="OMA" id="ACKRIRM"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="862" mass="95750" checksum="08B666DA7FC8A169" modified="2008-01-15" version="1">MSDVASDNGTVVHRSDVSTLPPMFQPAWKATPARGQDRLNAIGGDMFSPMKLQQMFLTPSLSSAREKEKEESSPLHTYGGDELDAAPPTRKEFTFRARQLPSSTPMPSRSSSKGTSRTTPSTPGGPHVPLRFIHVPFDSYLAEECSREASRDDEEGSSSPTLSASGSSSSLQDLRQNKRLRVASHETSSGQRLARFPLSYKSENIQPTPARPASGSFPRSILKGAGSIGETPRTHASRSISFVDQKHPRSTEASYSSAQAARLDRMLEELEHMNLTRSLSTYVPGPAPESKPDTASSRVPVQASLRSPTEPIPVRTKSLQPSRSLSALISDEPSQHHSTASFRITRDKLVEILTDAAPWAPDWQSLKRIDLRARHLESCIGLSEHLPQVEEVWIDHNQVSFTMGVPSCVRVLTASHNLMSELTSFEHLKQLQFLDVCFNEFASLMPFSHLPRLRELRVDHNKITDLRGLEQCTSLKHFSIAHNELSGRVDLSRMCWPAIQSLVVSHNRISSLVGLGHLDALQELHAEANELTDISIEHRMPQLRVLRLSDNNDFTELDVGRMPCIRTLYADRCSLASIGALGSAHTLRHLSLRQQSVRVCLPLPAPTQLERLYFAGNAIRSKPVFHAHMPDMVYLELAGCQLDQVSTELQLQTPALRSLNLDHNWLSTIPSLAHWHRLKRLSLVACRISTLECIVQGIRGLSELCVVDTRSNPCTLSLYPPMVLPLHAPDRMNGPPVPHPAIVQPDAAKAVEQQAQTRLRAAQALAERSQFHKRTMLLPPEPAAEAAFIEPEHAMDSARTAALFRAIDERFQCTLPMHVLQKRQVYRGLCGMACAPLTWLDGLEISDADVHRAERQLKLLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSU7</accession>
    <name>A8PSU7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732544.1">
        <property type="nucleotide sequence ID" value="XM_001732492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSU7"/>
    <dbReference type="STRING" id="425265.A8PSU7"/>
    <dbReference type="GeneID" id="5856850"/>
    <dbReference type="KEGG" id="mgl:MGL_0319"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0319"/>
    <dbReference type="InParanoid" id="A8PSU7"/>
    <dbReference type="OMA" id="RIARPDW"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="2">
        <location>
            <begin position="120"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="435" mass="48371" checksum="C3CCA99467EA1582" modified="2008-01-15" version="1">MPHRSKPVSVLLLRQPVSVLQGTDPYHDTFGPFCLPSFELSALDTRSSTPGSPRSEPQQQSAWGDICYRTASGNEKGLDNSAKEELNSARTGPESTSKHDYLMTHHMYSTESNQREFCITSFPILTHQTVHINELEGIIHRVHERSTSFDGIVLPSQRAAQAYHDTCIRVYQQMASQGNHNNLSNTSSAWSSMPFYVVGPATAKYVREMAVPAAFKPSHVRGEQAGNAESLARDVILKDIHTLGKPCEFLYLVGDKRSSSLLDTLRAHHAPAALHELLVYETSKHPRFEANCALLERDLPEHMSTASSSRPSSFSSQLRREGLVMTGYEPVAAEHELETDLWLRPPIQSMESFQPPQPAQPNWIVFFSPSGGNYALPELTQRRWIVPFERETGSKVACIGATTAQWVRQNLGFEPHAIAARPTPDALRSCITATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTH6</accession>
    <name>A8PTH6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732651.1">
        <property type="nucleotide sequence ID" value="XM_001732599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTH6"/>
    <dbReference type="STRING" id="425265.A8PTH6"/>
    <dbReference type="GeneID" id="5856957"/>
    <dbReference type="KEGG" id="mgl:MGL_0426"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0426"/>
    <dbReference type="InParanoid" id="A8PTH6"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09897">
        <property type="entry name" value="H3TH_FEN1-XPG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="5">
        <location>
            <begin position="279"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="532" mass="59743" checksum="C2D41E141889EC2F" modified="2008-01-15" version="1">MVFDHPEARLPQKARENAKRRTAHHLATQRHAWELARFVRLQHLLACVDTYNTLTLQEKSITSQLLRQRLPRRPLHKDLVFSHKHSSPSNSQIESLVQYAMDPQTQFQDDIYEPYSPELFTCVDECEVIDKYADEDTMHPIKWHNAPSRLADAIQAIQQDYMSITQSFSDMRESTSQRPISLAEEHLYVMLTTGILGADTNLVTHNIDEWHMMCSQLEQSVRRLGSDDTHALNWFPAQMCVRDMVSQLCMLSDRLVGVYRRASRLVPKQAYLDLMDLCRLMHVPVLVTGDGSLGGGPMHEAEAMASSLVLHGYADMVASEDSDVLLYQVPLLRGLSNMTLELVDSQQVCQQLFPSATSPFALFMEFALLCGTDFNRTVPGIAAVSAHRWISIHASVEAVLRAQHERYAPPDQLGLDTYLAELSEARAIFLHPPSVAQAADLAGLTTATATTSNNKTNNARVTAEPAWAAFLRKCAHVSSNSVPTYDPIKLARFLRAHKVWFTESVREACAVHDTDVPASERVPQNWATMTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTS1</accession>
    <name>A8PTS1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732694.1">
        <property type="nucleotide sequence ID" value="XM_001732642.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PTS1">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTS1"/>
    <dbReference type="GeneID" id="5857000"/>
    <dbReference type="KEGG" id="mgl:MGL_0469"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0469"/>
    <dbReference type="InParanoid" id="A8PTS1"/>
    <dbReference type="OMA" id="HCYDLLH"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="9">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="542"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="691"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="838"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="984"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1133"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1428"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1625"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1625"/>
            <end position="1639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1675" mass="189759" checksum="9C0A7A619A2B74CC" modified="2008-01-15" version="1">MAADKPINFAEHVQLQELGIAPESISFANVTLESEKYVCVRESKESGNSVAIVDLNHIQNVVRRPMSADSAIMNPDENILALKLQRQLQVFNLASKTKIKSHTSPQDVIFWRWVSPTTLGMVTSSSVYHWSIDNESPPQKVFDRHASLADTQIINYRVSDDGKWMVLIGISSNTVDANAFRIKGSMQLFSLERGVSQPIEGHAATFAELKTQDSVVPYKLFSFAVRTATGAKLHIVEIDHAPENPVFTKKAVDVFFPAEATNDFPVAMQVSRRYGIVYLMTKYGFIHLYDLETGACIYMNRVSGETVFVAAEQKSSNGIIAVNRRGQVLSVSVDADTIIPYILRTLNNTDLAFKLASRGNLPGADNLYMQQFHSLFSAGQYSDAIKIAANSPRGILRTPQMIEQLKQVPTQPGTLSPILQYFGVLLESGSLNRHESLELAKPVLAQGRKHLLEKWLKEDKIECSEELGDIVRQQDMNLALSVYLRANVPNKVVACFAETGQFNKIVLYSKKVGYQPDYATLLRHVVRVNPEQGAEFASSLVADEDGPLIDVERVADIFLSQNLVQQATSFLLDALKDDQPEHAALQTRLLEVNLLQAPQVADAILGNQMFSHYDRARIANLCEKAGLMQRALEHYDDLADIKRVVVHSNLFDNEWLVNYFGRLTVEQSLESLYEMLRTNIRQNLQVVVQIATKYSDLLGAPKLIEMFEKFRSFEGLYYYLGSVVNLSEDPEVHFKYIQAATRTGQIREVERICRESNAYNPEKVKNFLKEAKLPDQLPLIIVCDRFDYVHDLVLYLYQNMMLNYIEVYVQRVNSTRAPQVIGGLLDVDCDEGVIKNLLESVTGPIPVDELVDEVEKRNRLKLILPWLKTQIESGSEDQAVFNAMAKISIDSNKNPEAFLKENNLYDPLTIGKYCEKRDPYLAYIAYAKGFCDDELIEITNDNSMYKHQARYLVLRREPQLWAKVLAEDNVHRRSLIDQVTAVAVPESTNPEDVSATVKAFMTADLPHELIKLLEPIVLETSAFSDNRSLKNLLLLTAIRTDKAKVSGYIDRLTGYDVDEIARIAIDHGLYEEAFQIYSKAQQNLDAMNVLVEHIVSIDRAQHFANKLNQPDIWSRLGKAQLDGLRVKDAIDSYVRAEDPANFDEVIEIAERAGREEELIRFLQMARKQTREPKIDTEYAYCLAKAHRLSDMEEFLSMTNVADVLSVGEKCFHDGLYEAARLLFSSVSNYARLATTLVYLNDFPSAIEAARKAGNTAVWKQMHAACLNKREFKLAQIAGLAVVPHAEDLPMLIRAYEVKGYFDELLQLLESALGLERAHMGVFTQMGIALAKYRPSQLMEHLKLYWSRSNLPQLIKVTERAHLWRELVFLYVKYDEPDNAALTIMEHCSDAWDHDQFKAVLPQVANVEIYYRALTFYLEQHPLLLNDLLTVLVKRIDHARVVRMFKKHDHDNVPLIRSYLMSVQPQNIEAVNNAYNDLLIEEEDYDTLRVSIDAYDNFDALELAARLKDHELLEFRRLAAHLYRKNGRFDDSIALSKSDTLFRDAVETAAHSGEPSVAEDLLSYFVDTGNKECYAAMLFACYDLLLPDVVMEMSWRHALQDFTMPYQIQQARDTRMKLQTLEKEVRERAAKDSAKEKQDEDTPILGPGAFANRLLTASATGPDGMMMPPSAGGMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTU9</accession>
    <name>A8PTU9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732707.1">
        <property type="nucleotide sequence ID" value="XM_001732655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTU9"/>
    <dbReference type="FunCoup" id="A8PTU9">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTU9"/>
    <dbReference type="GeneID" id="5857013"/>
    <dbReference type="KEGG" id="mgl:MGL_0482"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0482"/>
    <dbReference type="InParanoid" id="A8PTU9"/>
    <dbReference type="OMA" id="KLHQMKY"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="555"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="587" mass="64670" checksum="ACD2F322292E8471" modified="2008-01-15" version="1">MANQSGLKRKAAAPTASGTAYRKAKSVMKESTKSKPSDSGVRANKSTPKGDKSDERTPKRVKTATGAQHDKGNTAPKKSVSSKSSRIENSLSKRSEEQDDAKQQRVIEPPVNKPTKAEVVQLRKTAAQDRQQINENQLRKGIKPGETGPLPKGIRIVAGTYERFLYGLEGTVQKDSQSSYSIRLEPRFIFPAHVSSIRCVACAGQDSKWLATGGMDELIKVWDLRRRKEMGALTGHEGTITSLSFPNRTFLLSASEDGVINMYRTRDWALLRTLRGHTGRINSVSAHPSGRVALSVGADRMIRMWDLMRGMGSASVKIGTEADRVLWDTLGTRFAVLTGRKIIVYATNMSKVAQIEHPKRLHDIGFVRTNITGNNDKRDDQHELMLVASESGILHVFDLDDLQGTGEDASPREVARLVGHTNRVRSAVATHVQANDGTERLLVTTISSDGYIRVFELCLSREEPLVPELEALAAYDTKKSRLTCLSAVGFDPDASDLPNEEEAESDDSDPEDSDFENADDTLQDNDLSDEDSDAELARLEEEIAQARKAGIIVEGVDEEDDDDDDGDDNDEEEDEVEGELEDEEEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTX8</accession>
    <name>A8PTX8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0538 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732720.1">
        <property type="nucleotide sequence ID" value="XM_001732668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTX8"/>
    <dbReference type="FunCoup" id="A8PTX8">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="GeneID" id="5857026"/>
    <dbReference type="KEGG" id="mgl:MGL_0495"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0495"/>
    <dbReference type="InParanoid" id="A8PTX8"/>
    <dbReference type="OrthoDB" id="937at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018794">
        <property type="entry name" value="UPF0538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444">
        <property type="entry name" value="UPF0538 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444:SF9">
        <property type="entry name" value="UPF0538 PROTEIN C2ORF76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10209">
        <property type="entry name" value="DUF2340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="110" mass="12647" checksum="1806A92B1EBE47D4" modified="2008-01-15" version="1">MKPLVLRDIDLTKCTTPQLIERCRHEVRTQPAFKAYRNVVADLDTIKLYTQAHGAKTTNLIINLDHPEWIFDSASDASLASLGVQNETELSLFHRPAYEAFLQHPETRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU21</accession>
    <name>A8PU21_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732743.1">
        <property type="nucleotide sequence ID" value="XM_001732691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU21"/>
    <dbReference type="FunCoup" id="A8PU21">
        <property type="interactions" value="484"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PU21"/>
    <dbReference type="GeneID" id="5857049"/>
    <dbReference type="KEGG" id="mgl:MGL_0518"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0518"/>
    <dbReference type="InParanoid" id="A8PU21"/>
    <dbReference type="OMA" id="QMEDEIM"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="145" mass="15855" checksum="C3FD66F66164E231" modified="2008-01-15" version="1">MDVTEAQVKELFSTTIGPLRRVLMSYRANGQSTGVVTVEFQRAEDASRAYAQYNNRLIDGKRPLKIEVVVDPARATMAAPAQPQKQNPPGAGKSARAAKRHAKAKRRKEARPTKTLEDLDAEMEDYSKQASSDVQPMQDGAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUS1</accession>
    <name>A8PUS1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732165.1">
        <property type="nucleotide sequence ID" value="XM_001732113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUS1"/>
    <dbReference type="STRING" id="425265.A8PUS1"/>
    <dbReference type="GeneID" id="5856471"/>
    <dbReference type="KEGG" id="mgl:MGL_0758"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0758"/>
    <dbReference type="InParanoid" id="A8PUS1"/>
    <dbReference type="OMA" id="SIHYVFR"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="382" mass="42507" checksum="CE7614604AADC98F" modified="2008-01-15" version="1">MSTSDVQRHAREDGRVQRHSEREDVHGNNEEEQHAPLTARQKASLRFLQVNTPISLLCCIATALFAAMIVPSIHYVFRSQPTYFSMAPLMLLAYSIVMLLFEFGFCLLAVITPNPHTQRCIVQGAGSRLALANYMLSMWLLCRIIDSTTTMVIGSCVLVGIAILTLTNGVVLRAKYRARWMHPLELLLVHVPNKLVFLFVAQVLLWDQLMLTWGWDRSLGRDALAKGFWFAVCVQTLSGIGLIVWITYTCDVSVYVISMFLDAAVLKFYKMPIIGPNARPFILTIIFFVSMFLRTIALLVPAMLQNGFLVICHTHRRHVPDAPYENPAVEDVSTSTPSALPPPSSAQPSVGAGASNDNDEESTERTRLLRHTDPAYGAVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUW2</accession>
    <name>A8PUW2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732192.1">
        <property type="nucleotide sequence ID" value="XM_001732140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUW2"/>
    <dbReference type="FunCoup" id="A8PUW2">
        <property type="interactions" value="551"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUW2"/>
    <dbReference type="GeneID" id="5856498"/>
    <dbReference type="KEGG" id="mgl:MGL_0785"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0785"/>
    <dbReference type="InParanoid" id="A8PUW2"/>
    <dbReference type="OMA" id="NTRDWIR"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="6">
        <location>
            <begin position="171"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="367" mass="42183" checksum="326F41BD6BE59D60" modified="2008-01-15" version="1">MPGRSLGLPIGYNRSSCGYCRAENQEKQERSFSYGFLAYRLEPDHYQTLLDHGWRRSGDYVYKPDNSRTCCPQHTIRLDAQAYRPSKAQRRALNQLYWTLCGRPKPARWKGKWGSTGAYDVEHHVRLVMHDDSSDIVDLSDSSWPPLEAPYDSIPNERIKLSLRRATSTDEKYALFRRYQKHIHREAEDEISSRRGWEQFLVRAPFPDEGDGQDKAHAFFGVYHHEYRYKGQLLAVGVLDILPHCVSSVYFFYEPAYADWELGKISAMVEICLTKALSRRISSLHWYYMGTSYRLPEPLPPGYLNFAAVQRKASQWLVLDTSTFPPLLTTFEVICTRSSHEMSHAISSFFSALGVSIGSLIVALACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV16</accession>
    <name>A8PV16_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP45010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732224.1">
        <property type="nucleotide sequence ID" value="XM_001732172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV16"/>
    <dbReference type="FunCoup" id="A8PV16">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PV16"/>
    <dbReference type="GeneID" id="5856530"/>
    <dbReference type="KEGG" id="mgl:MGL_0817"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0817"/>
    <dbReference type="InParanoid" id="A8PV16"/>
    <dbReference type="OMA" id="WAIVDVR"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="338" mass="37300" checksum="C0F3CE8F735F8113" modified="2008-01-15" version="1">MCPKDQLVAVTGATGFVGAHIVKQALENGYAVRSVVRSQEKGKQLLEHFPSSNHTVSFVPDIRDKEALEKAFHGVKVVQHVASPYTMAFDDARSEMLDPAIQGTLAVLEAADKQGVEHVIITSSYAAINCYEKGGAIRDYTYTEDDWNPATYDGAAASPNKVYIYSASKALAEKAAWNYLQKRPSFALTTFCPPGIVGPIVHPVKALDQLNTSCANVWRLISGQTNGQVPPTLLPQTVDVRDVAKAHVYAMSNPRSKGERFILRGYYIDMQVIVDYLREIFPSHRATIPVGEPGTRNQPGPVARLDASKAERLLGMTWTTWNETYKDLATQLWDMSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVL5</accession>
    <name>A8PVL5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731633.1">
        <property type="nucleotide sequence ID" value="XM_001731581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVL5"/>
    <dbReference type="FunCoup" id="A8PVL5">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="GeneID" id="5855939"/>
    <dbReference type="KEGG" id="mgl:MGL_0901"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0901"/>
    <dbReference type="InParanoid" id="A8PVL5"/>
    <dbReference type="OMA" id="REGMDMS"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF85">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="541" mass="60537" checksum="66E5DA289CA904CE" modified="2008-01-15" version="1">MNFKSKGVETKSTKESWHAAKNWDELPLREQLDTAEYKKLERSARLKMDLQVVPICLLLYLLSFLDKSNISQAVIDGEKQPDGSIKNPGIMTSLGLSPHDYAVALTVLYPPYMAFEIPSNLMIKRVTPRIWIPLLVIAWGLVETLQGLVTSRAGLYINRVFLGAAEAGIMPGIAVYLTFFYKPSELQFRQAFFFTGASLSGAFSGLLATAIRKMDGIAGQHGWQWVFYLEGIFTVLVGFLCFFLLPNRPESCFLLTSKERRIVVERLSEARETYRDRPELALKLEQTVPDVSEEQAPPPVPSPWHREVLRAFRDIRLLLLGALGFCVSMSIFSVAYFMPTIVKEMGDYSAAQAMLMSCPPYAVSFAYSLIVAVASDRLRMRYASIMIGLVLCVIGFAVVLGCERSMVRYGGIILLTCGGYAGPPCLFAWAANNSAGHYKRATALALIIILDNCSGLASSWLFNSKTEAPRFTRGVATNLAIAAFGLIVATAIELLVYYERKQRKSGRRDDRVIELYKKTGWSPEQLRDYMGDDHPEYYLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVM0</accession>
    <name>A8PVM0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_0905</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731637.1">
        <property type="nucleotide sequence ID" value="XM_001731585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVM0"/>
    <dbReference type="FunCoup" id="A8PVM0">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVM0"/>
    <dbReference type="GeneID" id="5855943"/>
    <dbReference type="KEGG" id="mgl:MGL_0905"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0905"/>
    <dbReference type="InParanoid" id="A8PVM0"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="6"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP44423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="378" mass="40516" checksum="E79262D434D7C4B8" modified="2008-01-15" version="1">MTQTFSIATLPGDGIGPEVVDQAVRVLELVSEKSTNFKLQIRPHDFGGAAIDATGEPLPAATLQACKEADAILLGAVGGPKWGVGKVRPEQGLLAIRKELDLYANIRPARFPSDSLLEHSPLRPEVAKGTDIVVIRELVKGLYYGDRKEADLDAPDSKGEAYDMMVYDKSDVQRITRLAAYLAMRSSPPAKIHSIDKANVLATSRLWRRVVNETIESEFREKGVEVDHHLVDSAAMVMVSNPRKLNGILLTENMFGDILSDESSVIPGSLGLLPSASLSELPTGESPCKGLYEPIHGSAPDIAGQGIANPVGTILSGALLLRWSLGLEKEAAAIEQAVRKVLDTTDMGGFGVRTRDLGGPATTKEVGDKVLQVLNDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVQ1</accession>
    <name>A8PVQ1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731659.1">
        <property type="nucleotide sequence ID" value="XM_001731607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVQ1"/>
    <dbReference type="FunCoup" id="A8PVQ1">
        <property type="interactions" value="789"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVQ1"/>
    <dbReference type="MEROPS" id="C19.A60"/>
    <dbReference type="GeneID" id="5855964"/>
    <dbReference type="KEGG" id="mgl:MGL_0927"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0927"/>
    <dbReference type="InParanoid" id="A8PVQ1"/>
    <dbReference type="OMA" id="RKVQFPF"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="69"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="465" mass="51653" checksum="485B687440D5EC35" modified="2008-01-15" version="1">MVPPERQKVMTKGGLLKDDTELSKLSVRAGQQFMVLGAVGELPKAPEKPVQFLEDMQEDELNKATDLRVGLTNLGNTCYLNSTLQVLRAIQPLQEALSEYKGRSGSNQGDAGLVAALRDLYQDMGKTTDAIPPLVLLTTLRTVAPQFAEMANSGVGFAQQDAEEAWLRIVQALSSVSIATPSSQPFVQQYMTGHLSIERTCPEAPEEAPSHADEPFQMLQCNISSTTNDMTAGILDSFSQKLEKHSDQLQRTAVYDEKRRIARLPEFLPVHFVRFYWRRDINKKTKIMRKVKFPRELDASPFVTPELAQRLAPVSSRLHAVQKDRDERAKIRARAKGRHLEPGAVEGGALTDEQEREQREKEAESIKALVHEDLRADAGCNASGLYDLVGIVTHKGAAADAGHYMSWVRKDAVDTQDSLDASPNEWYKFDDDKVSIVPADKIEMLYGGGEDSVAYIVLYKAKPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVT6</accession>
    <name>A8PVT6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731684.1">
        <property type="nucleotide sequence ID" value="XM_001731632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVT6"/>
    <dbReference type="STRING" id="425265.A8PVT6"/>
    <dbReference type="GeneID" id="5855989"/>
    <dbReference type="KEGG" id="mgl:MGL_0952"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0952"/>
    <dbReference type="InParanoid" id="A8PVT6"/>
    <dbReference type="OMA" id="RDMENEA"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="150" mass="16937" checksum="33BA8F80E827375A" modified="2008-01-15" version="1">MFQRALRYRVAFQTITVVAAAASLFYLRKPKSRVPEEPGPDGKPQQLMPWNPEKQERRDMENEAEWRSRFAGAQTRHERENAAIERMVQEAIARREQAAKELAAANATASPTSPEPTDTSQATAAVPDSKDQQNQSLLARLGQDKRAWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVW5</accession>
    <name>A8PVW5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal eL28/Mak16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731703.1">
        <property type="nucleotide sequence ID" value="XM_001731651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVW5"/>
    <dbReference type="FunCoup" id="A8PVW5">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVW5"/>
    <dbReference type="GeneID" id="5856008"/>
    <dbReference type="KEGG" id="mgl:MGL_0971"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0971"/>
    <dbReference type="InParanoid" id="A8PVW5"/>
    <dbReference type="OMA" id="GKYGQRP"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000002">
        <property type="entry name" value="60S ribosomal protein L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="151" mass="16520" checksum="F38D47D6788B130C" modified="2008-01-15" version="1">MSTQDLQWLLVRKSNSFLVKQKGLGRVFSREPGNVASLHSYKHSGLVNDKGVGIVPAENRGVIITTRKQKVSPRAIRSARAQTTVKGGSRRVAKAVANIVAKNGYRADLRKDAVARATSIVNSQVRKHHEPRVRAPRGASARKVLPAPKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW31</accession>
    <name>A8PW31_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731747.1">
        <property type="nucleotide sequence ID" value="XM_001731695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW31"/>
    <dbReference type="STRING" id="425265.A8PW31"/>
    <dbReference type="GeneID" id="5856052"/>
    <dbReference type="KEGG" id="mgl:MGL_1015"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1015"/>
    <dbReference type="InParanoid" id="A8PW31"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF5">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="3">
        <location>
            <begin position="319"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="588" mass="65587" checksum="7F7A02EE8C15EA04" modified="2008-01-15" version="1">MSLVVLNQQFAIYVESTNGIDSLFLLNRASRTRNRLNALPFTQFSQLCVSASTLTLVCIAASCYTSPALVAVNLRSFAALDDANFATTSSNEPLYRVLRSTQMIEFPRDYVSVPELITFPTQLHDGSLSMARALYYSPKNPNVRAPTGTLPPCRILAYESSTARELASLSPSIQYWTSRGWAICAMISDSDSEYRPYRWPWSHDRVQAERNCAAAAAYLGDTSLPWQRPCTASTPSSSLMITENENDGGSSFSDGTRSITVTRTDSPSLTKESALAFMLGSLAYAISTLVFRVRAEWLWILSALLVLVYRLGWRVQAESLRVFPHLGAQLETHRGLTLPNFFRSSRPYLRLQSARTFLPRDTILDFFMLEAIQHWRVLDYAVLVTSGSQKNGSLHVVFPHLLPPPPVYIHTFRRLHDTLMQHDTNSLSPPCRAIVDPNRICLSGRSVGSLIALETLLLFPGVFCTACSFLGVGDQALVAKHIQKYALRYIATLFCDIYEGIAGTNKAYGASSHAASYRVPFLLFRSGYDKYLSSQQSRDLVRIVSKTKAARVKYLEFPANTRKSSYAKICQQSLEIELAWCTNAALCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW39</accession>
    <name>A8PW39_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731752.1">
        <property type="nucleotide sequence ID" value="XM_001731700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW39"/>
    <dbReference type="STRING" id="425265.A8PW39"/>
    <dbReference type="GeneID" id="5856057"/>
    <dbReference type="KEGG" id="mgl:MGL_1020"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1020"/>
    <dbReference type="InParanoid" id="A8PW39"/>
    <dbReference type="OMA" id="GANEMHE"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="361"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="413" mass="47576" checksum="2CF8253FDDEFB9DA" modified="2008-01-15" version="1">MWKHYIVLFGGFVDTGVRTTYLQDLWIFDTLEYKWQEIKQNDLRRPSARSGFSFLPTPDGIVLYGGYCKKYVKGQRTQGLALDDAWLLQMDEDTSKIQWIKRRKIGYAPNPPRSGCTMALWANRNMGVLFGGVTDTEHDEESMESTFWNDLYGYQLAGMGRWISLNLRIPKKKKASKVDADDEVASDNENDDPSIMLPLTRYNTMLAVQRNTLYMYVHIRKSDLPGRYGGIFESGDREYTLDDFYTIDLSKMNRVICLKECPIDHLEWHSSDEEDDDDNDDDDDDDDEEDDNQGMETAEPEGVEISHMEEEEDGLCDLEGLRVSDEDLSDEAKAELEKKLALRRQATTFMGVSKDTTRSEADILSTPEPGEILKTFYERSKHYWAAQAHEIAQGQSRGKQLRRDGFDVCKMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW55</accession>
    <name>A8PW55_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731761.1">
        <property type="nucleotide sequence ID" value="XM_001731709.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW55"/>
    <dbReference type="GeneID" id="5856066"/>
    <dbReference type="KEGG" id="mgl:MGL_1029"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1029"/>
    <dbReference type="InParanoid" id="A8PW55"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS13-like middle region" evidence="3">
        <location>
            <begin position="82"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="4">
        <location>
            <begin position="955"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="722"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="924"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1719" mass="190549" checksum="3180C867E729F22F" modified="2008-01-15" version="1">MCRLVKTPQTAIGSPVPARRLSLPQSQPRSKSQPVKVPGDVAVAGGPAKASHYAADDTSSPASTSKTRIRIKLSSILLRLNDDGALLSTLTFSTADIALLLRANTMRVAARVGSLSLLDERQRERADPSFAKLLSIEGNELVDFALETFCPHDAQYPGYDTSIWLRCNTLKLIFVPEPYADLLAYFAKFAKMKAVYDAAKDAASAQASQLQASHSLTRYDVLVKTPIVVMPHDLRTNDQMTGYLGELYVHNTFAAKDDTTESVLHAGLRQIRLMTCMETEEYDGVHELTLLEDVDIAFKITERAPMARGAAAQAPTAPAKPSQDTLELSAQMTDINVKLTQRQYILAFALVRSLSALSMPDDTDVLPTDIVPEEDAARALETVEAQTPAEAGPLRKLVGQFSLNKVRLDLYDETAIHVDSLEQASLFCFTIEDTVLKMHQHPETGMEVEVDVRTFSVTDTRKSRDTHFREIFPAISTKDMQQFMLNYTVSPPPECHALVVVTVDSPKLIFSLDPLFALVAFVSSGLDDEPESTDSKPKAAMAGSTVKSVRRGLPATAASMRATRAPHAINMDTMPQAPSTSTSTATANTTAAAASSSASAAPGTSFRVNVVEPRIILLSSPTRPDSEAIVLQMRQVVLSQQTILALSLTQLGMFVWRMNSPNDRQRLLSNLDVSLSMDSRMTPSGKITSVEIDMGRLYVRLTRSDIELLVSVVSNAMALSKPDTDVDSTSLTSTKAAAAKPAPKRTEPARKGPTPSVLNKLADAFEDDGQVLFSREELTVRGAGLQCILISELHMLPVLDLDVSPFKLLLNDWSADMRMSTELDLGLNNFNLATSNWEPLVEPWTVSLRYERNLAPESSTFTISSGKRLEVNIAAQLIDTTTNMFMYLDQDNRLKEEARHMAPFRIRNRTGYRLTIWSETPYGSTTSSASSSSGTARNAPHHLDDGHDMPWTFSDWRTIREQTTEATYNRLAVHVDDMPWERVRHIAVDREGEYVMTLRPKLNRVSHRLLCEVKLVNNIKVITFQSTFRIDNRALIPFEVGLLDEQGQVTSSILRIEPETYSALPICDAYDRRIKVRPDPGLGYAWSNESVGWQDLLATASHTFVCPALDEREAPFQFQAFAIHDAQTMSRRNYPRVTLAIRAPVEIENVLPYDIHYRLFDKNLNLNWSGFLRRGGVSPVHVVALQHLLLLSVELEDSVYSPSEFAIIASDNPDDFQVESTLSLADESNLKLELRLHYHTYPDSGGAFKVQIYAPYIFLNLSQLPVTIKSRPWAGHSKIVAGQDLHEKDYDASEHSKPFLLSRLRESNNRFMLRTTDSSWSKPLSFDVIGSEVGVAIPSVNGDLELQLGLDIEDGLAKFKLSKVVKLAPRYLIHNLLPFAVRLAESQGGDPILIDAGDRVPLHWLHVASNKHATIAYHDAASEWTAPFSIDNIGFVYLRLIQHNEPQQLVQVDVQVHGPTVFVRLMPSSGAWPFLLRNETQHTVVFMQTASPTESQRSTRDTNPKRYVLKPRSKMKYAWDYPADPDKYIRLQINGSERVINILEIGSLLPFKFAARDNLSAGVVSLDVRADETTQTLVISDYTESKSNFKLLRDAGAAPGVGTVAAANAGHGIPGGDIRFKAVDIDTSILFAFNIELTGLGISLISSNVREIAYMTFRGLELSYSESQVTTAVNVICKWIQIDNQTLHGIFPIVLYPHCRAERRQRTRRAPNAPGVGDP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWF6</accession>
    <name>MYO1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName>Myosin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MYO1</name>
        <name type="ORF">MGL_1086</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The tail domain participates in molecular interactions that specify the role of the motor domain (By similarity). It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylation of the TEDS site (Ser-369) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EDP44604" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44604.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731818.1">
        <property type="nucleotide sequence ID" value="XM_001731766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWF6"/>
    <dbReference type="SMR" id="A8PWF6"/>
    <dbReference type="FunCoup" id="A8PWF6">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWF6"/>
    <dbReference type="GeneID" id="5856123"/>
    <dbReference type="KEGG" id="mgl:MGL_1086"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1086"/>
    <dbReference type="InParanoid" id="A8PWF6"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0505">Motor protein</keyword>
    <keyword id="KW-0518">Myosin</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0728">SH3 domain</keyword>
    <feature type="chain" id="PRO_0000338556" description="Myosin-1">
        <location>
            <begin position="1"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="4">
        <location>
            <begin position="42"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="IQ 1">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="IQ 2">
        <location>
            <begin position="753"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="5">
        <location>
            <begin position="786"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="1184"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="1">
        <location>
            <begin position="417"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="966"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1137"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1246"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1027"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1137"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1257"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1269"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="1322" mass="144430" checksum="AB9D9C35DEE6DBC0" modified="2008-06-10" version="2">MVISKRAGGRRAAGGAAAQAAPPVNRGIAKADWREGFKKPQAGVSDMTLLTQITNEAVNDNLHKRFSNAEIYTYIGNVLISVNPFRDLGIYTDEILRSYRGKNRLEMPPHVYAIAEGAYYNMLAYKENQCVIISGESGAGKTEAAKRIMQYIAAVSGDTTGTGSTSSGIHTIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIMFDANGSPVGATITNYLLEKARVVGQIRNERNFHIFYQLTKAASPQQRELFGLQGPEAYAYTADSQCLDVPGIDDHADFAAAFEAMRIIGLTDDEQMSMVRMLATILWLGNVHFVENAQGDAELANPDVTAFCAYLLEVDPSAVQRALTQRIMETQRGGRRGSVYEVPLNPTQAAAVRDALSKAIYNNLFDWIVARINRSLQAQSQTAASVIGVLDIYGFEIFENNSFEQLCINYVNEKLQQIFIELTLKKEQEEYAQEQIQWTPIQYFNNKIVCDLIEAKRPPGIFSALNDAVATAHADSSAADNSFMQRTSMLSSNPHFEARGSKFLVRHYAGDVMYNVQGMTEKNKDALLKDILNLVDSSSNAFLIGLFPERPDPNSKKRPPSAGDRIKASANALVDNLMQAQPSYIRTIKPNQNKSPTEYDTQAVLHQIKYLGLRENIRVRRAGFAYRNTFEKIVQRFYLLSRATSYAGDYIWQGDARSGCERIFLDTGIARDEWQLGVTKGFIKNPETLFALETMRDRYWHNMAMRIQRAWRAFMRRREESARRIQRAWRRSREGHEFLELREYGHQLLAGRKERRRFSLISMRRFMGDYLDLNGSSAEGRMLRASANLPPNEPIVFSARAQLLVSRLGRTSIPSPRFLLMSPRAVYILVTHLVNKRPQTTCERVIPLSTIRQVGLSTLRDDWIVLQVGTDEGDPLLHCDFKTEFVAYLLQQTGGRTHVVIAPQLEYVRKGRKKAHVSFRKDESIPVGDVYKSSIVSVGSGEPPTSVSRPPAKKLPRSAQPSTKRRTTSRPVTSRRPVPTVLPTTTASRGLPPAPGGTASASALAVPTTSTVAPASSASGNASGARHVPAPPPVSGGSGLPPYLQAPATSAPSSGMPSYLQRAVPAAPTAPAAPAASAAPTAAQSTSGIPSYLGSSTTKLAPPVTVQQLGSSSTAQTRSVPAPPSASATPAVATPALAPVKAAPLPPPPPTGRRLPRYRALYDFETQEAGELPLRTGDIVELEEKEENGWWLVKKGSTEGWSPADYLELIAEPAAAKPRPPPPAKPASAKPAAAPARVSQSSVTSSWTPPDSHAAPVAVMPGMGDPGGFAAILARKKAERAAAAEQAHVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWF8</accession>
    <name>A8PWF8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="15" type="ORF">MGL_1087</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731819.1">
        <property type="nucleotide sequence ID" value="XM_001731767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWF8"/>
    <dbReference type="GeneID" id="5856124"/>
    <dbReference type="KEGG" id="mgl:MGL_1087"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1087"/>
    <dbReference type="InParanoid" id="A8PWF8"/>
    <dbReference type="OMA" id="YLRYIPQ"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="57"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="441" mass="50622" checksum="8771A91A17BA1E12" modified="2008-01-15" version="1">MWPYYQRTPSFTFKQLAVVLGIFNVLILYMYYTYYCCVTADAGGVPIGWRVPEGCHYKRYCFKCRAFKPPRAHHCRVCRRCVLRMDHHCPWIGNCVGFGTYAYFLQYTTSVMISCSYHLVMTTMRVFDAWNTYYYMSHPTTLEASMLVVNYLLCIPTFLLVSFLTLYHYYLLSTNTTSIESWEMDRVYRQIRRGHIPFTTFPFDVGCWQNISSILGSRPWLWPLPKAPRGDGLAFPVAPLQDDPFAMYAWPPRDPHARLARPSMRRMRTRPGIHVQNDVHDNVQAPRFVQHHDGPLPSLQDANHAADDHTAHLTDMYDSYSSDGHEDDHALDGYDDDIDDQHSYAPSGHVRVRRGSEGYEVIPPHYARALWEDQGAAAFPPGTEPPPLPSQLWRSDLSPAGADKEGWPEYPHGTFAAYGSHVDDDEDYDDDLPLATLRGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWH5</accession>
    <name>A8PWH5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731834.1">
        <property type="nucleotide sequence ID" value="XM_001731782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWH5"/>
    <dbReference type="FunCoup" id="A8PWH5">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWH5"/>
    <dbReference type="GeneID" id="5856139"/>
    <dbReference type="KEGG" id="mgl:MGL_1102"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1102"/>
    <dbReference type="InParanoid" id="A8PWH5"/>
    <dbReference type="OMA" id="RENRSCW"/>
    <dbReference type="OrthoDB" id="2499604at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF2">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="454" mass="50063" checksum="916EFE8BADF8B665" modified="2008-01-15" version="1">MANVGVLDKRMQSKLNKLNVSVFTPALLFSKVAFYLTPERLSELAIVPIGFVCVTFMSAVASILTSRLLRVLPSQRPFVTACAITPNSNTLPVALISSLVYSVPELHWVQDGEDSDRPELMLGRALTYLVMFSTFGTIQRWSIAAKLMALVKMVHPQGLVMGNHGYAEGDGEESSRSGFRDDVTDWLVDQGHRSQWAEQNSIFHHTPVAGSSERAGLLSEEPDDIGTRRRSLMSHVSWNTIWQKYVLAPWRAFLDFMTVPLWTSLLSFVVVLIPPLQRVIVSFDSVTGAVEQLGQCSIPMSILVLGAYFSGSDAPGTDLVNRNSIIEEPMSEAQRKEIESWEKRVTWRTIIATCAARMIVAPLIILPAVAFLCLTNDSKIVDDPVFIACACLLIGSPPALTLAQISRQRGDPNGNLEALISGTIFVSYVFLTAPVTVLLVFVALYLDKMQARFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWL2</accession>
    <name>A8PWL2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Signal peptidase complex catalytic subunit SEC11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Signal peptidase complex catalytic subunit sec11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731871.1">
        <property type="nucleotide sequence ID" value="XM_001731819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWL2"/>
    <dbReference type="FunCoup" id="A8PWL2">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWL2"/>
    <dbReference type="MEROPS" id="S26.A04"/>
    <dbReference type="GeneID" id="5856176"/>
    <dbReference type="KEGG" id="mgl:MGL_1139"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1139"/>
    <dbReference type="InParanoid" id="A8PWL2"/>
    <dbReference type="OMA" id="VIKVHEC"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="107" mass="12291" checksum="CE35E11A6D176DBC" modified="2008-01-15" version="1">MSQKPIEVGEITVYQVPGTAIPIVHRVIETRETKNRGQLLLTKGDNNYDDDIMLYNGPRWIRDDQIVGRVQGFLPYAGYVTILLNDYPMMKYVVLGLLGISLFFERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWM5</accession>
    <name>A8PWM5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylglycinamide formyltransferase 1</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1152</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731884.1">
        <property type="nucleotide sequence ID" value="XM_001731832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWM5"/>
    <dbReference type="STRING" id="425265.A8PWM5"/>
    <dbReference type="GeneID" id="5856189"/>
    <dbReference type="KEGG" id="mgl:MGL_1152"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1152"/>
    <dbReference type="InParanoid" id="A8PWM5"/>
    <dbReference type="OMA" id="MHIVSET"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="201"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="333"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="816"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="823"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="839" mass="91374" checksum="54DB356D38322B49" modified="2008-01-15" version="1">MAHQESEDKPAPMRARAEALLARYGGPNGPTGHAAVNESGEPQSLSAFIGGKANAPRLGKLTGDGRTSSFDESQTEYQRLPGLTKPGSMASFMEQRQKELFPELTNDNDHKSKQETQHEEPSQPSDKVVSPGNEPAPTSITDTSLEAGNSATHGHDRNRDAQSDTKNQHETALKETERATDNASGTAHATPSLPKRSTSGKRIVVLISGSGSNLQAIIDATCGTSPEIPNAQIVRVISNRMKAYGLQRAKNVDPPIPTCVHSLKTYQTRNPGKTREDYDLLLAEHVLGDDGCAPDLVVLAGFMHIVSETFLSAMGHMTSLRSPPTFEKRPKRPVPIINLHPALPGAFDGANAIERAYEAFQHGRIQYTGAMVHEVVAEVDRGQPIVVHQVPIYKDDSLDVLESRMHSIEHDIIVQGAAKVLSGEHKVTAQAVPPEQQQHPSPPPVSLQPKSKSQANPCIDKMAVESAPGSSELQKLAATTFLRLCAHGVWLPIAQPLTLYETDVVWVNGGAASSYIWLGRSAPPNWEAMLSKESHMQLGTQPSKEHQGCESLTFMRAIGGMLVTMQGSPDEASLKEARKDTLFIVRKDDEENGVFVDQVPFEASSLCSAFSAVASTSHGVWVWHGIGSDDAQQQHAIAWTKSLAPTHKVVQTDEFFSLFDDREYANGWHHRRRPGLPGPKRCVKLYSPAHTTKPVKFCLKYIRTDAVSVVDAYLEIYVIIGAKARGDRNAIEAALDHAERLAIREDVTEMKPPIHVLVLPSVVPLDFLALARDAWNQHVLTDDEVDDHSPVLMNLHTLCEARRQLSTSKLSLSACSSSSTSTVPANQNYLPVGSQASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWN9</accession>
    <name>A8PWN9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731898.1">
        <property type="nucleotide sequence ID" value="XM_001731846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWN9"/>
    <dbReference type="FunCoup" id="A8PWN9">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWN9"/>
    <dbReference type="GeneID" id="5856203"/>
    <dbReference type="KEGG" id="mgl:MGL_1166"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1166"/>
    <dbReference type="InParanoid" id="A8PWN9"/>
    <dbReference type="OMA" id="RIPECYK"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000009">
        <property type="entry name" value="Related to CDC36-transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="120"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="302" mass="32787" checksum="2DEECE1BC440304A" modified="2008-01-15" version="1">MSRADLARMSHEAALRADNSGASVEGAPSLDIPALTSSHDTVQQQQQHRHHRPAAMYGAGGEVVHLPVQQVLTSPVDRFGLVGLVNLIKTQDPDVAMLSMGSNLQALGMNLDATDPLSASFVTPWTQDPIVASSQVEPAYQLPSCYHVQPPPAQTKVASFSDETLFFIFYSTPRDALQEMAAQELYARNWRYHKGLHLWLTKDPNTEPLQKTPTYERGAYVFFDPGSWDKVSKNFVLMYEMLEEKPTSQSMLAAASAIHAGAPSQLPTTAGGKSSHPSQSVAVTRGSSLSPPNQASPQPSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWR7</accession>
    <name>A8PWR7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731926.1">
        <property type="nucleotide sequence ID" value="XM_001731874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="5856231"/>
    <dbReference type="KEGG" id="mgl:MGL_1194"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1194"/>
    <dbReference type="InParanoid" id="A8PWR7"/>
    <dbReference type="OMA" id="VIPIWEE"/>
    <dbReference type="OrthoDB" id="66369at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14496">
        <property type="entry name" value="PTP_paladin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1357" mass="153914" checksum="E1F3262D258D74CB" modified="2008-01-15" version="1">MLPHMRILSSQWAHNERRIIRERHGSVLSRGLVLKRDRAAMNIDDALEHAIALEGAPLFREADMDLGVYGVAQPTVIGLKTVLSVLMCEPNREARSNRTRQCAWICTREEPVVYVGDIPYVLREAYKPKQTLSMSDRAENLEAIEKRLKHDILAEAAKNNGLVLVHEEQNGTIELKSKWVSVQNEDVRTVRELFSWIQSCGWRVSYHRLPIAPNQPLEHNYLDAYTQVIKNTDPRSTCFVANCGAGVFRTTFAMIAALLVRRRQMHLLTQVDPFAETGENMTSDTHVPSKSLGRTLRRVQDSMEQNHHLLRLVHVLSHSLSTYDTRSVIEQLLMQPTLLKSLQEANLGDYSMVRQLCGLLDHGLACKAVVDVAIDGCAQVINIRESILSHRLRYSTAAAIDELDAHSLLRHAAKALEVYYFLIAFASYVEESKTALFQFRFVDWLKERAEIWRGIGRIRGLRHHLSLFEPVADLSLISRGDAAELAAPNDSVKQRFGEVRAQGALVTGDEFAEFVVRNRAGTVLRPGLLLKRDVWLEFSLHDKAHQVRGAVNFRRVAHTNIFGTGQPSVEGIRNLLITVLDDELMQHIDENCSVLWINLREEPLVYVSGRPYCLRQRELSLRNITDYSGITPERLAQLEDRLRHDVVRELSSSDNKLLLHSETEDGTVVPLWEDAEASDIATVQDVMDQAATSLPKHSQLIFRRIPITAEKSLEYSDVEDLLHTVLHSYDARMPIIVNCQLGRGRTTLVSVFILLIERWMGNTPPRPSTGSGPRLTYHLINSLLRVVPHGQEIKRVVDDAIDACGFILNIREAIEQERLRALDASSDDERQQHVVYGVRSLRRYFNILLFQAYLDSVRPDTIVTQSYEQFVRKQPVIETIARDLERIDLSTLTPLRKVDIGDGLALTDEVEEVVRNRTGNILSASTILKSDFFSGILKAGLPIRIDGMPNLRCVCPLIPLQHTRVTPPTPAAISTAQETWGCGMPTIDGLRAGLTRMGAGVGGRTQIVWTNLREEPVLYVNGRPHVLRLADEPLTNMEATGVTTDVVERIECALQRDLRDEAQRRDRRVLLHDEVASGDGEYTIVPVWETVHDSDILTPREVYERMRNEGFHVDYARVAITDEQAPVPDVFSQLEERVQHAIDIHAMCVFNCQMGRGRTTSGMVIASLIVSVREFGHSWLEQRAGIAMDEAHTTDESRELREDELRTDGEYRCILQLVGVLSHGRLAKTLLDRVIDRMETIQNLRKAISMMKLRANSAEPGSPRHKQLVTVFRNYLGRYGYLIAFASYLLEKIRFKEQIWQDDDTSSIMPSPQYLAHRPRPGSMDEAADQTRAFPCFPVWLQKRREISGILDREELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWU9</accession>
    <name>A8PWU9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731957.1">
        <property type="nucleotide sequence ID" value="XM_001731905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWU9"/>
    <dbReference type="FunCoup" id="A8PWU9">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWU9"/>
    <dbReference type="GeneID" id="5856262"/>
    <dbReference type="KEGG" id="mgl:MGL_1225"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1225"/>
    <dbReference type="InParanoid" id="A8PWU9"/>
    <dbReference type="OMA" id="RERANIW"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="448" mass="50788" checksum="17C10A91E15C40B6" modified="2008-01-15" version="1">MKALVSAFSDQYLRKVWLAMTRQGLGASLWRRPRRADLVVLLGDLTDRGRWYDSYTDWNQLQLRWMSLFRNLRVMRYSLHSPLRPDVHDGSWPALIVPGNHDIGIPAYETGKPSTLNELAAGWFQHDYAPLVDDDDYVLKTNGTASWNARIPISVNHRSTTHELVLLNAMDLVTMQPLGHGPIENWDSAKERALTTTKMIDLLGSVRPPAGQDVPRILFSHVPFERRANEHLCDVPSRSAVHGVRRESQRARVPGGDILQGGDLERTYQNLVHINVSDYVLDTIQPAVIFSGDDHDHCEAIHRGYRKNASGTVVTGFQATDIPELTVKSMSMVEGVKRPGYAWLQLQMNGDVPSVDYTPCLLPNQIALWLQVYLPLFVLTLAFVLFAPAFIRSNQSLLPIHQNQLPTKRRNLNLFVRTSSMGAFLRRLGRDIGHIAIFPLLLWLFLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXC7</accession>
    <name>A8PXC7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731220.1">
        <property type="nucleotide sequence ID" value="XM_001731168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXC7"/>
    <dbReference type="FunCoup" id="A8PXC7">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXC7"/>
    <dbReference type="GeneID" id="5855527"/>
    <dbReference type="KEGG" id="mgl:MGL_1403"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1403"/>
    <dbReference type="InParanoid" id="A8PXC7"/>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="122" mass="13964" checksum="2DC160907FBD1B7F" modified="2008-01-15" version="1">MPFPADTPFEDGTFKLLLTFDESYPNKPPTVKFLSKMFHPNVYANGELCLDILQNRWSPTYDVAAILTSIQSLLHDPNPNSPANAEAASLYRENMKEYVRRVKLTVEQSWIDETEDAHDTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXC9</accession>
    <name>A8PXC9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731222.1">
        <property type="nucleotide sequence ID" value="XM_001731170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXC9"/>
    <dbReference type="STRING" id="425265.A8PXC9"/>
    <dbReference type="GeneID" id="5855529"/>
    <dbReference type="KEGG" id="mgl:MGL_1405"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1405"/>
    <dbReference type="InParanoid" id="A8PXC9"/>
    <dbReference type="OMA" id="DWHENCN"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="152"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="425" mass="46169" checksum="E770DA0AE743A992" modified="2008-01-15" version="1">MSQDGASDLLGPSLADLPPQPSMFRTVDLLREVERVRDARKCLRIDPKLPPESATAGDAKPPSEWEGVPRTVGLPSVCMYTFYDAEDGLTSSTFSPDLTLMAAGFEESYVQLWSLKGEPLQSLESDFNLSAIRDRKSLNKHRLPYSGTSRKLIGHTAPVYQVSFDPVGGSGSSPRHLLSCSADGTARLWSLDTYAALVAYRGHQYPVWDVSWGPIGTYFATASADRTARLWSAERIHPLRIYAGHLSDVDCVRFHPNSLYLATGSSDRSCRLWDVQRGACVRLFVGHQSPVSCVRISSDGRYLASASGGSTIAGLGQPRSARADAFSISLWDLASGRRIKKMWGHSAPIHEMDFSADGAVLVSGSEDATVRCWDVRTAQQEPSASDADASADCVATYFTKNTPVYDVHFSPRNLCLAAGVYSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXI4</accession>
    <name>A8PXI4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731271.1">
        <property type="nucleotide sequence ID" value="XM_001731219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXI4"/>
    <dbReference type="FunCoup" id="A8PXI4">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXI4"/>
    <dbReference type="GeneID" id="5855578"/>
    <dbReference type="KEGG" id="mgl:MGL_1454"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1454"/>
    <dbReference type="InParanoid" id="A8PXI4"/>
    <dbReference type="OMA" id="QYEGTML"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002709">
        <property type="entry name" value="Probable iron inhibited ABC transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="83"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="395"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="629" mass="69836" checksum="2C702031EB912BA3" modified="2008-01-15" version="1">MPPVSASKAKRQAEKAAKAAAKGEKVGSSKDSVATSESGASASTKATSVDENGGPITDMKKLAIATERNAAGVIVSDKQSRDLHIESFSMSFHGRLLIDNATVALNYGQRYGLLGENGSGKTTFLEALANRDVEIPEHIDIYLVRGEADPSDENALDYIIKSAREKVARLEKEIEDMSVADEVDDVGLELKMEELDELDPNTFEARAGAILYGLGFSQAMMNKPTRDLSGGWRMRVSLARALFIKPHMLLMDEPTNHLDLEAVVWLEAYLSTYNHILVLTSHSADFMDNVCTNIIDLTIQKKFITYGGNYSTYVRTKTENEVNQMKAYYKQQEEIAHIKKFIASAGTYANLVKQAKSKQKIIDKMEAAGLVEPVVQPKQLRFNFEDVRKLPPPIIAFNDVGFSYSGKEEDFLYKDLSFGIDMDSRVAIVGQNGTGKSTLLNLITGVLQPVAGSVQRHSGLKLGKYSQHSADQLPYDKSPLEYIESKYKEKFPDKDVQFWRAQLGRFGLSGQHQTSPIRTLSDGLRNRVVFSQLAMENPHILLLDEPTNHLDMGSIDALANAIKEFEGGVVIVSHDFRLISQVADELWEVKDRKIVNLTKQDISIQDYKKILMKQSADAIERAKITAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXJ4</accession>
    <name>A8PXJ4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial distribution and morphology protein family 31/32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1461</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731278.1">
        <property type="nucleotide sequence ID" value="XM_001731226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXJ4"/>
    <dbReference type="FunCoup" id="A8PXJ4">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXJ4"/>
    <dbReference type="GeneID" id="5855585"/>
    <dbReference type="KEGG" id="mgl:MGL_1461"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1461"/>
    <dbReference type="InParanoid" id="A8PXJ4"/>
    <dbReference type="OMA" id="DFLCAEN"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="457"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="72389" checksum="90BBEFBF6F383097" modified="2008-01-15" version="1">MAKSFWTRMRIHFKWITIRGFRRFNIDDFSAFFTLGGLGTAIWVIVGTTTFVSVIFAALSLLNMQEWIALQLAKILSKQLGFTIVFGSAIVPKWKEGRISFKDVVITRRAEPTDPETLHKEHKAEDGHLMKGTSSTPAMQLGDAPSIPAYDTSDHIVSPLHQQESPSSEPKQDPHKNFSMFELHIDSIDVQLSLSRWLDGRGFLHKMDVRGIRGVIDRRHVFWDANRPYNPREARRKAKPNDIDLESFTVEDFLVTLYQPGDFRPFNVSIFDARIPRLRAQWLFYDLLNADSMTGQVDGCLFSLHKPQSVHHTTRSIYSKMGSHSAPYIQNWSRLRVDGVNIDHVQKMAGLSGPLMWIYSGRFDLVADIKFPKQYGEDVDINTIISEIRDNLNATFSGERVSSASSDDVLIPGQPELSGPAILAPVTAVGPAAERARQQRAVHDAVKLEEKRRELRRTKLLPNGLPRADQDQVGKSSTSLDEAAAEAASPSSVPTTSVSDADADDETSDIRPSVVIELDVRFKDIKASMPIFTRELSYSTYALARPIVAFMNANKTLIPVDCRIIMDLSEFDGSLDLSQTGLPPLVSEKIWEALANHVASQQANHQRVRNVSLWSLHILSQGLLRLARHWRDILARVTPPEVPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXK6</accession>
    <name>A8PXK6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731286.1">
        <property type="nucleotide sequence ID" value="XM_001731234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXK6"/>
    <dbReference type="FunCoup" id="A8PXK6">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXK6"/>
    <dbReference type="GeneID" id="5855593"/>
    <dbReference type="KEGG" id="mgl:MGL_1469"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1469"/>
    <dbReference type="InParanoid" id="A8PXK6"/>
    <dbReference type="OMA" id="ETRECES"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="4"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="781"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="843" mass="93461" checksum="ADF3BE637C32CCFE" modified="2008-01-15" version="1">MQSPLLALPTKETRDVDLVKPMSHLIVKNYEQDPATFADELHGIAQVRQDATGRASTETTGRDLLFRYFHIIEMLELRFPELEVPFTWLDSFSHDQVEQTALAYEKACVLFNTAARITHVSAQFNRSDANTDGLKRAYTGFRQAAGLLQYVKDSFLYAPSDDMKGPSLESLVKLMLAQASEIFLEKTIHDKKGDGLVSKLACHTATSYASLLTEWNDEACTVRVPYMWHQLVECKSNHFTSVAHMYRAKADRAAGKHGDALARYRYAEVKARLAVSQATLDTWSLATYLRPTLPVDATAALKHLAQVQLTNAGEACREAERDNDVVYHERAPDVDTLPPLDQTSVATAIPIREIFSQSEVQKVLGADVLPSLVPLSVLQNTSVYTEEQAKLVRAESARIDAANERIPEAFSALNLPDSLERFASLDGAPLRPCIPSSQVLDMSDELVACQACTRVDRVLESLPKRSAPVVSTLDDALADLDTDARECERGRVQHAATWTQAPTASVARALRRDIHAARDALATAKENDVGMSRLWDEVREDVALLERGRSAVSAAYEERAHVSPSMDLIDADLSDPEPARRLYVELKAHLNALERMPLERQAMLQELKQRVRHDDISRTLLLHRRVQNVEQTLFAQELGKYAPLQKQIRHHITLQSQRIDVIRDALERLATHPGAADVRRHWDASEGAARDMNERLSRAYNAYTDVQRAVAQAQVFYDDMSYSANQLAAATERLVAQRRAERATFLSSAGHVSNEACATSSAATPPTTLAQDLEALRMNESHAKHRGGAPPPPPPPRLSSSSSFTSSLAQSFGRATDQAPTGHTMSSDYADKKPVPPPRPPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXQ6</accession>
    <name>A8PXQ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glomalin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1502</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731319.1">
        <property type="nucleotide sequence ID" value="XM_001731267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXQ6"/>
    <dbReference type="FunCoup" id="A8PXQ6">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXQ6"/>
    <dbReference type="GeneID" id="5855626"/>
    <dbReference type="KEGG" id="mgl:MGL_1502"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1502"/>
    <dbReference type="InParanoid" id="A8PXQ6"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="61111" checksum="40ADED547CC9F67C" modified="2008-01-15" version="1">MAIMRSTAAASRMPRMLNSRALSTSAAALAHKEVKFSNEGRAAILKGVNLLANAVSVTLGPKGRNVIIEQPFGGPKITKDGVTVAKAIDIKDKYENLGARLVQDVASKTNEVAGDGTTTATVLARAIYSEGVKNVAAGCNPMDLRRGSQAAVDAVIKFLEENKREVTTSEEIAQVATISANGDKHVGTLIATAMEKVGKEGVITVKEGRTLEDEIEITEGMRFDRGYISPYFITDVKTQRTEFEKPLVLLSEKKISALQDILPTLEAAVTMRRPLLIIAEDIDGEALAACILNKLRGQLQVCAVKAPGFGDNRKSILGDLAILTGGQVFSDELDVKLERATPDMLGTTGSVTITKEDTIFMNGEGNKDAITARCEQIRSAMSDPSTSEYDRTKLQERLAKLSGGVAVIRVGGSSEVEVGEKKDRYDDALCATRAAVEEGIVPGGGVALLKGTKALDSIATANFDQQLGVSIIRNALTRPARQIVENAGEEGSVVVGKLLENPGEFGYGYDASVGEYKDLIAAGVLDPLKVVRTALQDAAGVASLLTTSECCIVEAPEEKPMAAPGMGMGGMGGMGGMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXR1</accession>
    <name>A8PXR1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SMC hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731322.1">
        <property type="nucleotide sequence ID" value="XM_001731270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXR1"/>
    <dbReference type="FunCoup" id="A8PXR1">
        <property type="interactions" value="624"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXR1"/>
    <dbReference type="GeneID" id="5855629"/>
    <dbReference type="KEGG" id="mgl:MGL_1505"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1505"/>
    <dbReference type="InParanoid" id="A8PXR1"/>
    <dbReference type="OMA" id="ECAGTTI"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="6">
        <location>
            <begin position="479"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="225"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="360"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="700"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="795"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="957" mass="106559" checksum="E27D22F71CA18A8F" modified="2008-01-15" version="1">MRIEELIIDGFKSYPVRTHVRGFDPSFNAITGLNGSGKSNILDAICFVLGLTNLSSVRASNMQDLIYKRGQAGVTKASVTIVFDNSDKDRSPVAFENYATITVTRQIVMGGASKYLINGHKATQQAVQNLFQSVQLNINNPNFLIMQGRITKVLNMKPAEILSMIEEATGTRMFEERKERAFRTMTKKDQKVPYEWHTVNRRLEDHSVSGLASVRQRIYDKESDIQSWKHHVESLHAELRALEKRRAAQVGAGAASLMEQSKTLNHQLVEASAQLEFRQAARDEEARRVDTESAALEAASAALSAQEEQHASLESSFADFKTAYDAQSTAVSEQESLLQSLLTGMASGQHETQGGFQGQLAKAREKATAAKSEVQQAQVQIDHIERELRVKEPQAKHEAQESRALYKKLANVQQAAQEAEQALHAYAFDEKRYEQLRAERLSLEQDMQRLASEREAMQDRLPSALQFTYVDPTPDFDRRRVKGLVASLVHLDPSNTKYATALETCAGGRLYSVVVENEHVGAQLLAHGQLKKRVTLIPLTKIQAHVAPSAQGVGTHSASRLARWIWHSRSSAMSRTWPQALQYVFGSTLICRDAATAKKVTFDAAVRMKSVTIDGDVYDPAGTLSGGSTSSSSSSILLRMQQMAALSAQWNAKHAAHEATNNEWCALQAASAMHAKLSSAVELKQHEATLVQQQVDGGRAASLQADIRACYATLEELRARMEAARQKQADAARQMADIERDIAELGVDKDAKVAKVRDTCKNMKSAFAQQAAELKQRQAALRASELDRSQHRMDADAARERLHEARALLAQAEQDVKDSAESVEALRMRVSESEEAITKEQAALSAFSDEHHELQTALTAKKAAVEDAELTLKQWRRELDQQEHEHARMQQTKDALESAFPWIVEECHLFGRVGSAYEFAKHNMDDVRKLCKQLDEQQSGLKRRVNPRVMNMIDNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXU0</accession>
    <name>A8PXU0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731341.1">
        <property type="nucleotide sequence ID" value="XM_001731289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXU0"/>
    <dbReference type="STRING" id="425265.A8PXU0"/>
    <dbReference type="GeneID" id="5855648"/>
    <dbReference type="KEGG" id="mgl:MGL_1524"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1524"/>
    <dbReference type="InParanoid" id="A8PXU0"/>
    <dbReference type="OMA" id="GKEMYEL"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="360" mass="42206" checksum="BCCDC6F9DC42CCFA" modified="2008-01-15" version="1">MSFQNISKSAVRIGKNYIKGYTDTQIKVREATSNDPWGPSGTQMNELSQLSHNATDFIEMMEILDKRLNDKGKNWRHVFKALSVLDYLLQEGSENVWNYFHDNIYIVKTLKEFQYVDDANIDQGINVRQKAKEITAILMDETRARNRRRMRMENETRNRDPHDFSDEAGRRRRQQQRDRMTAEDRELEQAIAESRRMAEEEEARRRRAAQDDSDLQRALEESREEERKRKESETLIDLDKDETPSTLQPQYTSFIPFQPTGFNPFFQAQMQQQEMMQQQYMQQQEYQRQLALQQAAQQYQYLMAQQQQQAMMPQPTSFGSNNPWLSQSSMAASSVPTPSAPPSTNASSQPTDTPDQSRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXX9</accession>
    <name>A8PXX9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731366.1">
        <property type="nucleotide sequence ID" value="XM_001731314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXX9"/>
    <dbReference type="FunCoup" id="A8PXX9">
        <property type="interactions" value="656"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXX9"/>
    <dbReference type="GeneID" id="5855673"/>
    <dbReference type="KEGG" id="mgl:MGL_1549"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1549"/>
    <dbReference type="InParanoid" id="A8PXX9"/>
    <dbReference type="OMA" id="LVMNYVW"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000039">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="9">
        <location>
            <begin position="227"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="10">
        <location>
            <begin position="985"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134644" checksum="496E12CBD21BD027" modified="2008-01-15" version="1">MSNEELDDIQRLRASRPSALRSGIGLASNKEDKDIYGSGSSRSNYVESIPVRRGDVDNDASDDDEQPRRANPLDAFTAPQHLLNEFADDSFDPLAERVAQRQLATRQSDYHNRRFQRDAGPDSQRDPFAQPSEEGDAPAEEGYRDAMRRAQVEREEHRVRRIIEEKERSMDYQSPAAEPSETMGQGALPQRKRRWDVAPDDVRPAAHEGATLPASSATDTETDTSSTKRRRSRWDEIPAEDTGVDTSKRSRWDQTPAGEFSSASTSSSTSTTAPPATASDSVATKVPFKPARVRYMSDSELDALLPSEGYTIVEPPPGYAPVRTGAHKLTEAPEGESGFTMHESSTLGGMADDIVADLPTDVPGVGQLAFMKPEDQKYFGKVLQEEDENERLTRAEAKEREIMRLLLKIKNGTPPLRKQALRQIADQAREFGPGPLFDKILPLLMERTLEDQERHLLVKVIDRVLYKLDELVRPYVHRILVVIEPLLIDEDYYVRIEGREIISNLAKAAGLAHMISTMRPDIDHADEYVRNTTARALAVVASALGIPAILPFLRAVCRSKKSWQARHTAVRVVQQMAIMMGCAVLPHLRNLVDCIEKGLEDEQQKVKTMTALALSALAEASAPYGIESFENVLKPLWLGIRHHRGRGLAAFLKAIGFIIPLMDSDSTLYFVKEITPTLIREFQSADDEMRRIVLKVVRQCAVTDGVTGTFLRAELVPDYFKAFWVRRMALDRRNFREVVETTRALADKVGVSDVVGRLVHFLKDDSEPFRKMAMDAIQHVVASLGTADVDERLEVQLVDGMIYAFQEQSVEDRVMLNGVGTIANALGMRINPYLMQIVSTILWRLNNKNASTRQQAADLTTKLAVVIKQCGEDALLSNLGLGEEFPETLASMIAAEGAIANVVGMTQMNPPVKDLLPRMTPILRNRHERVQEASINLIGRIADRGAEFVSAREWMRICFELLDLLKAHKKAVRRAAINSFGYIAKAIGPQDVLQVLLTNLRVQERQSRVCSTVAIAIVAETCGPFTCPPAILNEYRTLEFNVKHGCLKALSWVFEYIGEMSKDYVYSVMTLLDDAFTDRDVVHRQTAASIVKHLALGTAGLGREDAMQHLLNLVWPNLFETSPHVINAVMEAIEALRVSLGPGVILYHTLQGLFHPARKVREAYVRTYNTNYVGAQDALVAYYPSLDDQPEEHRDYARHDLAMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY48</accession>
    <name>A8PY48_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731407.1">
        <property type="nucleotide sequence ID" value="XM_001731355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY48"/>
    <dbReference type="GeneID" id="5855714"/>
    <dbReference type="KEGG" id="mgl:MGL_1590"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1590"/>
    <dbReference type="InParanoid" id="A8PY48"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="408" mass="45486" checksum="2338C8E2139B9958" modified="2008-01-15" version="1">MHDRRIPLDVPLLDAWSSHTDVWNALIRARVMKGDIVGARIWLERFRLVTSESFAPILRTTYSCLPPIKSASPYLTLMHSMSTSQGIHHLLAHVSRAERARLERHATSLDAPFKTAAIYDVLDAVRQDGVVPGVALLNFLASFEAGCGRVERGASLVLQALSLERGPAFAFKRTHPQTLDSRPPAPTLGSRLHISSVSVLCILHAAEAQRVASLEKARMHMPSITTAPIRTTALQPLACTPFPSPSMSSSHLNVSTMRGVLAHCMELVESPKRPSSAKRQAASWLAKKGSNLLNDMLRAMLFVNDFPGAWYTIGLYRKWGITPNAYTHLALWQRFSHTHFFTHDLSLPTATIEAMRTTLQHVIEQQMHELIRSEKIETPVWAALCQEQCASAGYAMHQIEWDALQRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYU1</accession>
    <name>A8PYU1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydroneopterin aldolase</fullName>
            <ecNumber evidence="4">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">7,8-dihydroneopterin aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731541.1">
        <property type="nucleotide sequence ID" value="XM_001731489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYU1"/>
    <dbReference type="STRING" id="425265.A8PYU1"/>
    <dbReference type="GeneID" id="5855848"/>
    <dbReference type="KEGG" id="mgl:MGL_1724"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1724"/>
    <dbReference type="InParanoid" id="A8PYU1"/>
    <dbReference type="OrthoDB" id="5425486at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="DIHYDRONEOPTERIN ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroneopterin aldolase/epimerase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="139" mass="15209" checksum="C437ACB178FF73C0" modified="2008-01-15" version="1">MQAGVDAWGRSVPQPLHIDAHIFTDVARAGQSDHIQHTHNYGTLYRALERFATENACSSMIHAAEGCMQVCLEECHAPYAEVHVRLPRALLHADAAGISLVRSARDAATTHGMMQLEHGMLRIHGLRVDAILGVNPWGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZH7</accession>
    <name>A8PZH7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730921.1">
        <property type="nucleotide sequence ID" value="XM_001730869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZH7"/>
    <dbReference type="FunCoup" id="A8PZH7">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZH7"/>
    <dbReference type="GeneID" id="5855228"/>
    <dbReference type="KEGG" id="mgl:MGL_1920"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1920"/>
    <dbReference type="InParanoid" id="A8PZH7"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="379" mass="41909" checksum="A0C33D40AFFAAE13" modified="2008-01-15" version="1">MSQSPSPLDASRLVIHKSDSLRQCPPVKDIVFGRTFTDHMLKIPWTAARGWGEPSIEPYGPLSLEPSSVVLHYAVTLFEGMKAYRDDHGKVRLFRPEKNMERMNRSASRICLPNFDETELLKLIKKLVQLDQHWVPSEPGYSMYIRPTLIGTEPSVSVTQTSEALLFVILSPVGPYYSSGVKPVALEANPQYVRAWPGGTGNAKIGANYGPGVMPAMQAAARGYQQILWLFGEEHYVTEVGTMNFFVVLKKDDGVWEVVTPPLNGLILPGVTRLSILELLRAHQNGEERLKNVPKIEVNERDIKMQELVDAANAGNIVEMFGAGTAAVVSPVNRIGYMGKDIHVPVGESGFGVITEAVLNKITGIQWGKEEHPWSVPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZT9</accession>
    <name>A8PZT9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730950.1">
        <property type="nucleotide sequence ID" value="XM_001730898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZT9"/>
    <dbReference type="FunCoup" id="A8PZT9">
        <property type="interactions" value="702"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZT9"/>
    <dbReference type="GeneID" id="5855257"/>
    <dbReference type="KEGG" id="mgl:MGL_1949"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1949"/>
    <dbReference type="InParanoid" id="A8PZT9"/>
    <dbReference type="OMA" id="GEMMPPR"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="5">
        <location>
            <begin position="301"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="568" mass="61324" checksum="D5058F974CDBB2E5" modified="2008-01-15" version="1">MATENEEVYEDLRTVLFSDSAVSGEAAGYAMGLVYLGTGSSQATEEMLQYAQETQHEKIIRGLAIGIALLHYGRESAADETINVLLSHKDATMRYGGAYTVALAYAGTGHHASVSRLLHLAVSDGSDDVRRASVIAIGFLFFRSPEHVPELVQLLSESYNPHLRYGAAMALGLACAGTGLDAALDLLEPLTKDTIDFVRQAACMALAMVLIQQNEELNPRVQTARKTFEKIISEKHEETMAKFGAAIAQGLIDAGGRNVTMGLRGSGGSTNAAAVVGMALFTQYWYWFPMAFFASLAFTPTAILGITKSLQLPALELVCHARPSLFAYPPPLQSPTEKKPEKVETAVLSTTAKSQARQRTKEKKKALESMDTDADDDTATSKSQPHDAQNTSGTSPDGPHSNKLNHKMEEPNEARLMNGSRVTPFQLKYMSFPPHARYTAVRPLAGVSSNLPRADASSARQLDMSVTAGRGGIILLHDREPSAPFVAAKQDKPGSEEKMNHEAAATMMAASSDAEKVQTSMQESLDDAEGDKKGDEKNEREGNDHRDRDGGTSANAITEDVDMNEQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0C2</accession>
    <name>A8Q0C2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2011</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731012.1">
        <property type="nucleotide sequence ID" value="XM_001730960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0C2"/>
    <dbReference type="FunCoup" id="A8Q0C2">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0C2"/>
    <dbReference type="GeneID" id="5855319"/>
    <dbReference type="KEGG" id="mgl:MGL_2011"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2011"/>
    <dbReference type="InParanoid" id="A8Q0C2"/>
    <dbReference type="OMA" id="MSAPFCR"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="237"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="308" mass="33385" checksum="F23ACF8A8EA1F76E" modified="2008-01-15" version="1">MGILSTPISTHIRPSSLASVNPRVAMSAPFCRNLMSRRAINVAPTVKQVANGTPIVPGLNLRVAAPSDSHGHDHGHSGPRSDMGTMPSWTSKSLFRRHSLLSRMAVNANVTGTGTQVRGFSSSARFLQAPDFSETRVKNPEVHRAFSYFMIGTFGAVSAASARSTVTNFLSTMSASSDVLALAKVEVDMSNIPEGKNAIIKWRGKPVFVRHRTQAEIDEANQVDMSSLRDPEADSDRAKRPEWLVMLGVCTHLGCVPIGEAGEYGGWFCPCHGSHYDISGRIRKGPAPLNLEVPEYDFNDSENKLIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0I8</accession>
    <name>A8Q0I8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731040.1">
        <property type="nucleotide sequence ID" value="XM_001730988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0I8"/>
    <dbReference type="STRING" id="425265.A8Q0I8"/>
    <dbReference type="GeneID" id="5855347"/>
    <dbReference type="KEGG" id="mgl:MGL_2039"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2039"/>
    <dbReference type="InParanoid" id="A8Q0I8"/>
    <dbReference type="OMA" id="NNIVESC"/>
    <dbReference type="OrthoDB" id="69550at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23680" checksum="9B328E6041953291" modified="2008-01-15" version="1">MRRPKRKRSRKVRTAIVSSDESSDSDITSQAASARTASPSSSSASSVSSDDDDDTSLSQSEQARHSNDQFDEDDPAHDAMELDDPDAKHNTLLPPNLVFPGQAESSSASHYKRKAPMERRISTMSSEDISKELAEKQRKAFHALYMQALTDDFENDLDHIRQHDPRLMEDASTSRATGRMTLLVDALSFGSEAFTHAQASSHQVALALPTNQTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0P6</accession>
    <name>A8Q0P6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2063</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731064.1">
        <property type="nucleotide sequence ID" value="XM_001731012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0P6"/>
    <dbReference type="FunCoup" id="A8Q0P6">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="GeneID" id="5855371"/>
    <dbReference type="KEGG" id="mgl:MGL_2063"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2063"/>
    <dbReference type="InParanoid" id="A8Q0P6"/>
    <dbReference type="OMA" id="EMFQAPR"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="509"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="543" mass="60361" checksum="3C8CADA1633F5D09" modified="2008-01-15" version="1">MRLNHIVHGAPVGYTTYAIGGLASMGGFLFGWDTGQIADLLIMDDYRNRFAQHDVPGQPKEWNTWIRGLLVSLLSAGAVFGALVGAPISDKLGRRLSVTLGCILYMVGLIIQISSDHGWPQMAVGRIFDGLAIGWLSSAIPLYQSEIVPRQVRGAVVGTYQLFITLGILMSYCACYGTHSYSDSGQWRVPMGIGFAWGLLLGSCILLCPESPRWLGKRGQFDKTKRVLALMRGVDENDAYLNNEFEEIKQEVIKEAELEESGTWLDCFSFKQKALYRTFLGMYLQMGQQLTGANYFFYYGATIFRKVDLMDTETDNSYISQIILGAVNFVTTFPGLYALDKLGRRTCLMTGAAWMTIWLIVFATTGVADSNGDEIKHKSTSILMICSACFFILGFASTWGPGVWSSIAESAVPTLRARQMALATMSNWIWNFNLAFFTSPITDDIHYAYGYVFVGCCAASFLVVYFFVYETSNLDLEAIQDMFGDPSVKPWNSHKWVPAGCTTRSDAKHDIEHTKPENDEFLTPDQSELRTGDEVPIETGEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0W4</accession>
    <name>A8Q0W4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731092.1">
        <property type="nucleotide sequence ID" value="XM_001731040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0W4"/>
    <dbReference type="STRING" id="425265.A8Q0W4"/>
    <dbReference type="GeneID" id="5855399"/>
    <dbReference type="KEGG" id="mgl:MGL_2091"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2091"/>
    <dbReference type="InParanoid" id="A8Q0W4"/>
    <dbReference type="OMA" id="FKPQRGF"/>
    <dbReference type="OrthoDB" id="3364971at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="835" mass="91577" checksum="2264AB0FC8115F29" modified="2008-01-15" version="1">MAHMDLQVESGVSALGGSPPNSNILPYQNERFSTRTSPPAYGSVYNENNEDDSDLGELVTGNGQNSPQQSDAPTLSGNDSDDSDMAREIEAAGEVESLIGSDNSSDDEHLANEEQYMIEEELHRANPNEHDGSKHQQASNVQQNVFGDDYDYWDSFSPANGSAEDDDVIANELFKPQRGFASSPEPLFSDFYGSSIDSDQDGSSDLENEKNDNHGDGIHIFGSSPSSDDDETSSDNDASISDMEPMSMPLIAHVGATQGVDVDDADRESGDDDGEAGEQALKNAMPLLVIEDLDGRLVYARAGDGEAVFGSDGEFEFEGESDEESSDDEIPLQSPSKESTPHPHPEDSHVSDYDVPDIDDGETTDELPDNDMPYPRLLVGSIAPHGGRNARRAREIAARSRNNSPRVSSRAPSPVTIGLSARKAPSTLSNVLSVNDHDNDNSSSESVQAVDDQNAHGKEAHLKRPQITQDLYNMSPEHLKPPMGQFMPTCSKSVHRAVIDGSNRAPSPFSTSHHMQRGTRRKRSRFQPDEDSFDQVVSGYPSSRKRRNSDAFNTLQHNCVPARPTDSNGSPESLPEPLEQDPAGPMDLSDVLDEGLLWQGSSDGDSIHDDAVSDFRQSKPRSQNAPMPDKTCDRAIARWTRIPMGAFRSAQQYGVSTNPSTMSDAYWTHQRPSSSFLITQAMRNPRQALDRSHTSTYGTPHQTHTPFRWSVTTLQNPRNPVSPLHRTLADAAMSDLTSKSEQSRKEKYRQHRLGRKLGEHAVIGGNFVVSPVLRPVKHRQQKSDLNGINSLTSPLLAIGDAAPSDHSPLNKAHIRKVAKHEKRDRLARQEVVRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1J0</accession>
    <name>A8Q1J0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730796.1">
        <property type="nucleotide sequence ID" value="XM_001730744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1J0"/>
    <dbReference type="STRING" id="425265.A8Q1J0"/>
    <dbReference type="GeneID" id="5855103"/>
    <dbReference type="KEGG" id="mgl:MGL_1795"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1795"/>
    <dbReference type="InParanoid" id="A8Q1J0"/>
    <dbReference type="OMA" id="GGHIGPM"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="766" mass="84524" checksum="8A51383E74931055" modified="2008-01-15" version="1">MQRAAATQLAYTRMLAPRARLARSGVCGVRVAFSTITIPDAPVVSRRAAPHEAAASRASGSPASSSDIATATFFSSSIPTSIATHVHEQGAGAVLVRMLESSERIPPEQLWSLYECALNERPQKLPDGSVRVPPKLEARHHQRVLQLLLPAQDKYVHYVRERQRIASLRRDVHASDDEALLPSCTPLDLSTPDTLAPVPPVRGMGGKNARTFARRTRQVLLEIAPAERTAAAYNDVLRVLSHGGRYRYMRDLWNDMLRVRETGHVQAAPNQDTCHYMMVGLVRNFEQKLQRYKTRYERELLTSARHVRRAQPQPPSSSPVPPAHRTAAAAEHVQAAALQAAHTVSMLLLDIQKQGTLPRVLTLDLAARVLRLTGRLPEFLHLLRSGFGLDLQYPDASVPALCTPTTHTLNTTLMALGELARMPDMAVAFEVMTQPLSHAHDTQRWPVLPNTTTFKLLVRHACSAPPTLLVSNASVQSTTARAILSRLSAGPQGLPTIGIHTAEQRDAEVQARCRGAYLALARAYVDDALRMYAEQLSRMAVQLRMPRPSVLHDSIEAVHARENERRDAGMVGEQGMESMSKRWLASMEKEAALSDEAVDDKSGTHLPPSSEKDRAQDVLSSSPSEPVFVPPNVRVSYAMLRPILASTYQKRSLGQLAWLHSRADMAAVLLSAEHTLLQHAQAQVQADGMLSSLAAHATYVQRLWEGMQRLCDTWVPWHMERWSDAEYARNARRNARASKKQRTRRRAAATATAAAATATSPANQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1N5</accession>
    <name>A8Q1N5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730816.1">
        <property type="nucleotide sequence ID" value="XM_001730764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1N5"/>
    <dbReference type="STRING" id="425265.A8Q1N5"/>
    <dbReference type="GeneID" id="5855123"/>
    <dbReference type="KEGG" id="mgl:MGL_1815"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1815"/>
    <dbReference type="InParanoid" id="A8Q1N5"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="49" mass="5813" checksum="B0ABC16E228D6C3B" modified="2008-01-15" version="1">MLDLAAENRITPWVEVMDMKECSKAIERLEKGDVRYRFVLQQDLDVNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q272</accession>
    <name>A8Q272_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730703.1">
        <property type="nucleotide sequence ID" value="XM_001730651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q272"/>
    <dbReference type="FunCoup" id="A8Q272">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q272"/>
    <dbReference type="GeneID" id="5855009"/>
    <dbReference type="KEGG" id="mgl:MGL_2157"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2157"/>
    <dbReference type="InParanoid" id="A8Q272"/>
    <dbReference type="OMA" id="WAITYLC"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725427" description="V-type proton ATPase subunit" evidence="10">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="8068" checksum="EA387BB58A962166" modified="2008-01-15" version="1">MSGWTTIWVLFAAILTGAVSWYTTPKGPNQLLIRTSVIMVLACCYMMWACAYLAQLHPLIQPKRGDVRFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2T3</accession>
    <name>A8Q2T3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730436.1">
        <property type="nucleotide sequence ID" value="XM_001730384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2T3"/>
    <dbReference type="GeneID" id="5854743"/>
    <dbReference type="KEGG" id="mgl:MGL_2232"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2232"/>
    <dbReference type="InParanoid" id="A8Q2T3"/>
    <dbReference type="OMA" id="HESCTND"/>
    <dbReference type="OrthoDB" id="3351982at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="728" mass="77941" checksum="16EF589AE3D48D80" modified="2008-01-15" version="1">MNKEANVAGETELPRRATRSRKLPCWLRSPSPTPLSAHKPAEKLERSSTRVAEGTITQTTDANTAGVRDSAIVTPAASTSMLNTAGTSSSKETGPGKRQRRPSSMYKPPEALTADLNRTSPLTTASPSLSKSSKSSRSRTKPSTKTEDDSSRVSTRITLRVPSRSAQPRTQSPSASTSTTPSSCALASKPNVPERMAGEVTPSSKPTIPPSSEASSIPVTFTRRGECFSEPHRPRHESCTNDMAGIMSPKPVRTADGVCRMGMAPVSDDEEDDEEEDHVVDELARDALHVDFAERAWAISIDDAKYRGGHAEIFCAAAEQGSYGRNEALDIGNLGDGSRIDAGAFRDACSGGCDDYEDDDDDDNDFHQTMLQDAELDMLTRVDSPKGSEDDDALTDGHATTPASCGLKDSPDEIRSCTPPMSEETKDTVFAHALPVPHPRTSDSGTHAGSLTLSLPYEFAACTTSTPLPDANGETPLTPVHTMTAAELAEMSSCQDEEKNNGLPALAAPSLPSDLSRDSPNSVPGSPASPTVYRVSNSGWEDSSAACPTTNQSVNMNFTDVQYQEHDFHAGDSGRLDSLPEPPLLDDVFESSETSPAPHEQDIIPKNEGWLCIDTSSNVKLPSHLHDDAELDPFFSPPEKMMALTDLDRAWDWLGDLSETSAASHHSADRKRKRNTHALVRRPRAAIAGKATTTVSPTSGGDGSTSTASSCTLNQPRSRLSRLRSRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q339</accession>
    <name>A8Q339_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_2304</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730508.1">
        <property type="nucleotide sequence ID" value="XM_001730456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q339"/>
    <dbReference type="FunCoup" id="A8Q339">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q339"/>
    <dbReference type="GeneID" id="5854815"/>
    <dbReference type="KEGG" id="mgl:MGL_2304"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2304"/>
    <dbReference type="InParanoid" id="A8Q339"/>
    <dbReference type="OMA" id="EDHRKFG"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="452"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="694"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="15">
        <location>
            <begin position="823"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="999"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1001"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1016"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1052"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1062"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP43294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1094" mass="120113" checksum="61176FC164C3B07E" modified="2008-01-15" version="1">MVEMCAALQPLWESGSTEDAHRHAEVLTEHINTHGVRTLMSERILEALLDKLKSKKHAEDRERAAIGLGAIASKVAGKNAPLPLGAEPWLIPAIAPLLETYADKNEKAKQAAESAMASIVPLFPPEAAAELLDVLYGVIMSSTAKWQAKVGALKIIGRLADLAYEQVGDELTQMTPVLTQAMHETKAEVSKQAIKTATKVCGVIDNNDIRPFIPDLVGCMARPDSVPACIKKLSSITFVAEVTGPALAVMVPLLSRALNERSQTVQRQSVIIVDNLCKLVRDPHTAALYLPGLLPSVERIEEGASFPEVREHAKSAVHTLRTAFAAADASKQDPQGTDPLARLAEARSKALQRLADAVQPRVPTGVVFSALGDAFTRTGLEYVSRVVVRLADKRIVQAEPWNDVYVLPHLRRVCETAEGAQNATNLLREEYEKLDFERFGKPEDDGSELDGEKLCDTIFSLAYGGLLLLNHTRLRLYRGRRYGIVAANGSGKSTLLKAMRDGKVEGYPEQDKVRTVMVEHSLQGEDGSKPILDFVVSDPKLAGKNRDEVAEALHSVGFDEERQQTPVGSLSGGWKMKLELARAMLIGADILLLDEPTNHLDVGSVRWLENYLISNTNVTVLTVSHDSSFLDNICTEIIHYEHKKLKYYHGNLSEFVKTRPEAKSYYSLAATSVKFTFPPPGSLMGVRSNTRTILKASHVTVHYPTMPRPSLVDASVSVSLSSRVGVVGPNGAGKSTLIKVLTGEIVPNEGKVEKHPNLRVAMMAQHAFHHLEQHLEKTACQYIRWRYQDGHDREITEKATRKLSAEEAEQMKVPIVAQTGEKRTIEFIVGRSKLKKSYQYEIKWVGLEHKYNTWIPRERLLELGFSKLVQKFDDFDASREGAGSRDLSQKAIRSELEAVGLNGEIAENNAMGGYSGGQKVKVVLAAALWNNPQVLVLDEPTNYLDREALGGLAVAIREWAGAVLIISHNQEFINALCPEIWNVENGRIVSKMRTDIASENFADSNPNTPAGTEPNSAAPSAPGSAAPSAPASAAPSAPASAAPSDDEDMSKLKAKKGKKKMTRNEKKAQEERRRLRLNRWLQYGGEREPDTDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q369</accession>
    <name>A8Q369_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730528.1">
        <property type="nucleotide sequence ID" value="XM_001730476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q369"/>
    <dbReference type="FunCoup" id="A8Q369">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q369"/>
    <dbReference type="GeneID" id="5854835"/>
    <dbReference type="KEGG" id="mgl:MGL_2324"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2324"/>
    <dbReference type="InParanoid" id="A8Q369"/>
    <dbReference type="OMA" id="EHEHAFH"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="4">
        <location>
            <begin position="84"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="323" mass="36447" checksum="01F5CFB319F96BEC" modified="2008-01-15" version="1">MCMSANGRRVVHLGIFSRQRMRRLSSYRAVVSRCTRAFSNASTPPTCGQPLPHTHPHLFPIDFRRGTDASKGGGVAMDHLTPGIPASEYEDRRRRLMERLPPKSVVVLMGGRIKYMSRNIFYKFRQESNFWYLTGMQEPDAALVLEKTGHGPRGYKMTMFVEPRQLHKEVWDGPSCGMEGATRIFGADEALPNDPSVMLQFFKTAAAHAEQLYVDLPAQVSTPRQSLRSPRFSIHEFLAPSSPSGYDMFVRKTDFDNVVKLLSDRRNTHSLEREMDVLRSCKSENEIKVMRQAGAISGKAMSQVMRAVQPGMEEASSTSPFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3I7</accession>
    <name>A8Q3I7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2415</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730619.1">
        <property type="nucleotide sequence ID" value="XM_001730567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3I7"/>
    <dbReference type="SMR" id="A8Q3I7"/>
    <dbReference type="FunCoup" id="A8Q3I7">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3I7"/>
    <dbReference type="GeneID" id="5854926"/>
    <dbReference type="KEGG" id="mgl:MGL_2415"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2415"/>
    <dbReference type="InParanoid" id="A8Q3I7"/>
    <dbReference type="OMA" id="HWFPFVG"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="BRENDA" id="1.14.13.70">
        <property type="organism ID" value="13511"/>
    </dbReference>
    <dbReference type="BRENDA" id="1.14.14.154">
        <property type="organism ID" value="13511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="534" mass="59862" checksum="6ACD64AE103390D4" modified="2008-01-15" version="1">MLQEIGAWPVWQQALTFLVGGLALIVGINVLVQVLVPRNKSLPPMVFHWVPVVGSAITYGMDPYRFFFNCREKYGDVFTFKLFGRNVTVALGPKGSNLVFNGRLTQVSAEEAYTSLTTPVFGKGVVYDVPNAVLMEQKRFVKSGLSMENFRMYVTQIESEVKDFINNDAAFLPLQKGATSVTVDIFNVFSEITILTASRTLQGKEVRESLDKTFAKLYHDLDSGFTPINFVIPNLPLPNNFRRDRAQRLMSDFYLGIIKKRREGNTEGTEHDMISALMEQSYKNGRNINDREIAHMMIALLMAGQHTSSATGSWAMLRLASRPEIIEELYEEQKRVYSDGTGGFAPLDYDIQKSSVPVLDAVIRETLRLHPPIHSIMRKVKSDMVVPPTLAAPISSKGSRDETYVIPKGHYVIAAPGVSQVDPKIWEDASRFDPHRWLGDKANVMNQTDDAQEDFGWGMVSTGANSPYLPFGAGRHRCIGEQFAYLQLGTIISTFVRAFDWRLETKLPAPDYTSMVVLPTQPANLVFTPRKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4H2</accession>
    <name>A8Q4H2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730159.1">
        <property type="nucleotide sequence ID" value="XM_001730107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4H2"/>
    <dbReference type="FunCoup" id="A8Q4H2">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4H2"/>
    <dbReference type="GeneID" id="5854466"/>
    <dbReference type="KEGG" id="mgl:MGL_2541"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2541"/>
    <dbReference type="InParanoid" id="A8Q4H2"/>
    <dbReference type="OMA" id="MISYRTH"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="287" mass="31772" checksum="62AF51779B425D35" modified="2008-01-15" version="1">MGGSMGGATSLEWPLCFPVRTPSSPDAITSTSSDKPYVRSIVVLAASPRHSAWCIAWCEIQRQAIEADTRFNGGRYLLRDPPQGGLAAARMCALMTYRQPHSFERRFSRMRGKSNLAPSPPKEESQASSLMEEGGDEDVDVSKISQPQAQEQYAVQSYLHHHGTKFLTRFDALCYIHLSNKLDSHDVTRDRESWASGAKDDATVLKGVLGHLNKPRNSPHVLILSVTSDMLYTPAEQASIHEAIPTSELVHIESAEGHDGFLIEYPQIDRAIRAFMERLNVSHASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4M2</accession>
    <name>A8Q4M2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730191.1">
        <property type="nucleotide sequence ID" value="XM_001730139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4M2"/>
    <dbReference type="FunCoup" id="A8Q4M2">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4M2"/>
    <dbReference type="GeneID" id="5854498"/>
    <dbReference type="KEGG" id="mgl:MGL_2573"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2573"/>
    <dbReference type="InParanoid" id="A8Q4M2"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13865" checksum="2A4289D8E0F04356" modified="2008-01-15" version="1">MPATTIPIVKKRTKRFARHQSDRFKRVAPNWRKPTGIDNCVRRRFKGTIAMPKIGYGSNKKTRHIMPNGFRRFVVANPSDMDLLLMHNNTFAAEIAHNVSSKKRIQILEKYVLSDVLNTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4N3</accession>
    <name>A8Q4N3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730202.1">
        <property type="nucleotide sequence ID" value="XM_001730150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4N3"/>
    <dbReference type="STRING" id="425265.A8Q4N3"/>
    <dbReference type="GeneID" id="5854509"/>
    <dbReference type="KEGG" id="mgl:MGL_2584"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2584"/>
    <dbReference type="InParanoid" id="A8Q4N3"/>
    <dbReference type="OMA" id="TESMPRI"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="269" mass="29217" checksum="922BAFA395FFABB8" modified="2008-01-15" version="1">MGQNCIGIERFLIPDSMQDDLVQAVKPRIAALRCGSTLDDTSMGHGAKAQQGKNGDHVDCGAMITDARFDALEELIADAVAHGARLVVGGKRYNHPRWPHGHYFSPTLLTHVTPTMRIAQEEVFGPVFLVMPYRTVDDAVAIANGTPFGLGASVFGRDYKECQHVASQLTCGMVNINDFGISYLNQGLPFGGCKHSGYGRFGGPEGLLGLTAPKAITEDVWFGVVQTSIPPVVDYPVRDTQRSWTFLHSLVRLAFGSLVQRIHAIRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4V8</accession>
    <name>A8Q4V8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730270.1">
        <property type="nucleotide sequence ID" value="XM_001730218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4V8"/>
    <dbReference type="STRING" id="425265.A8Q4V8"/>
    <dbReference type="GeneID" id="5854575"/>
    <dbReference type="KEGG" id="mgl:MGL_2652"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2652"/>
    <dbReference type="InParanoid" id="A8Q4V8"/>
    <dbReference type="OMA" id="EIYLWIS"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000135">
        <property type="entry name" value="forkhead box protein G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="889"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="889"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="628"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="988"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="171"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="989"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1059"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1267" mass="137358" checksum="EE1BB9D12B68B2DD" modified="2008-01-15" version="1">MTVVSDHHLDSHPAEDQNGRTASLVTAPTSSGQAPSSSDNADDFLARAQALGLRLSRSDYERTRAGVTAFLKAERLPPASPYKSETSDDRASGSIEHEHARDVAPQLARWLRTTSGQLSFFTAVVHPTQTTQTSDEHRTRLSLDEVGSAEEKRRRRMRRRRLLEKHMLQESGARSPSGSASISGSGTAPVPIAGSSDDSASRSRTGSPQRPARAGSSFSHAQQHAHQHQHQHEPPVSLTTQPLGPSLNEDGPRVSPPGSPDVKILNRIARVDPAGKLWLAPQDPSHELLSEDSSTHAFDEQQSVADTSDDTSSHAMHSGGQRSFSRTSSGTTEQLNACMKNMSLLDRIMMSKTSPRRMRREAKARERERTQHEAIAEASGGNPGVSNVPGSHEVEPAPDTSLSSWADVSTLDSPPSKLPCTSEPHLIAPTPTTSAVASRVSHARHTSLSSSSSSSLRRSHHHLQTPSHDHRYARADALCEMSPVVSLTPLSRFDPGTQITPMRYSPGGGVDYSYSRSTLAFSPHMLTPWTHQGRLMSNAGLSNVPSSPFVSGEWSSAQPMMSSSTATLRGNFAFSSTPLSHLPSHDPDLSVPFASSPSRLQCIESFPGRSPQGRDMMISPTRKALVLSPLASKGHSRPASRSPLARRASPTTPIPAASSLSPLWRQLSSMDERSPRRRTDTIRPTDVFSSAVPSMAQSSEPSGSSPAIVSTSTPVKAPLERSRSSQAGIGAVVTATVQASQTSEASDASFPHNESPKAGSDDVADISQASASSPELRTRHGLPRVRLPRRKSASSRSSTAASSMTPMHSDDVFAKDRTPMEASFNDVFYEAVSTSDPSKTEWDLPDGRRIVKLVSEELQAALDSGSLKQEPKPRYFCLPPGYGKSRTKPSSVSYAGLIGQAILSSSDGRLSLAEIYLWISSVYPYYERGDRGWQNSIRHNLSLNKSFVKLERELTMPGKGGWWAIQPGHEHRFQQGMYLAHGGRLDTAPTRSFRPSPSVTLSDMVEDSNRKKRLPLAPCDTNVMSSTNTRDTPRLPTVKRPKTARPTKFIPTRSGAEAQQQMQQQPQQQRSASETSFVMRDGMHTPLATSPANEKLDADSFDTSTSRSLLATPGNPAATAPLMSVSHAFRSSPSMQIRHAPMAPPMPLMGMPTVSNAPNDLYARTFTNMPDCGMMYMNQEMPYGEYPVPMTSSPQKQAHFHPTTLSQPPPMTPMHMHSMQPPFTHLQAHVPVVPAGYTRYVPDQGGGGIPSSWPDALQMGLKGDATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q518</accession>
    <name>A8Q518_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730317.1">
        <property type="nucleotide sequence ID" value="XM_001730265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q518"/>
    <dbReference type="STRING" id="425265.A8Q518"/>
    <dbReference type="GeneID" id="5854622"/>
    <dbReference type="KEGG" id="mgl:MGL_2699"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2699"/>
    <dbReference type="InParanoid" id="A8Q518"/>
    <dbReference type="OMA" id="WYLMISP"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="76"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="226" mass="25001" checksum="BEFD76D542BEB962" modified="2008-01-15" version="1">MTRSLPTKQHAFPFPSAPRSPDDTSPAQVQLAAAALDRLSMAPASQEDEKRCMRVPFHDESDGVAAIRDRLGGAAHCSAFISKLWHLMINPDLYGKYIRWNEAGDAIIINSEPEVAAEFAAEVLPRLFKHGNNASFIRQLNLYGFQRVSSSRLLDAAEMRAVAARTSGSNWFGAPPPFNTAMELYGAHSSFAHPRFRRGHEAWLVSMKPRSSKKSKKTSSEDTKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q580</accession>
    <name>A8Q580_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2746</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730364.1">
        <property type="nucleotide sequence ID" value="XM_001730312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q580"/>
    <dbReference type="FunCoup" id="A8Q580">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q580"/>
    <dbReference type="GeneID" id="5854669"/>
    <dbReference type="KEGG" id="mgl:MGL_2746"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2746"/>
    <dbReference type="InParanoid" id="A8Q580"/>
    <dbReference type="OMA" id="HHRSWVV"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="52"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="159"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="420" mass="45143" checksum="3621F3348A26DCC8" modified="2008-01-15" version="1">MQSGPLPTLYRPYLALGLEGSANKLGAGVIRHTPPTGHDGHGAAINHARVDILSNVRHTYVTPPGEGFQPSDTAKHHKHWILSVVAEAVRASGIASIAEIDCICYTKGPGMGAPLQAVSIVARTLALMYNKPLVGVNHCVGHIEMGRTITGAHNPVVLYVSGGNTQVIAYSAQKYRIFGETLDIAVGNCLDRFARVIGLSNDPSPGYNIEQEAKKGHRLFPLPYGTKGMDVSLAGMLSATEAYTKDARFRPTKRGVSTTDVPVGALANGRIWTGNSAHALQRSEDTVNVRSCEQDNISGLDAERDADIITPADLCFSLQEYMFAMLVEITERAMAHIGSKDVLIVGGVGCNERLQQMMGIMASERGGSVFATDERFCIDNGIMIAHAGLLAYRMGQSTPLAKSTTTQRYRTDTPLIAWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q674</accession>
    <name>A8Q674_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729884.1">
        <property type="nucleotide sequence ID" value="XM_001729832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q674"/>
    <dbReference type="STRING" id="425265.A8Q674"/>
    <dbReference type="GeneID" id="5854191"/>
    <dbReference type="KEGG" id="mgl:MGL_2870"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2870"/>
    <dbReference type="InParanoid" id="A8Q674"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="421" mass="46131" checksum="DFABAC248BFE3DAB" modified="2008-01-15" version="1">MADQPRYAGAAAGTSDEDEQLMRALAASVSSNESNIQARPELDRLRHGSEPVVFVPSIPTYKAAAFALQALYAAEPVRSAWLSYPIPDRRTDSVAMYWAGASTTLTYSVIQRLQTLFGFATFTARAAVATGDTDALLPKDVILRASHQESLCVLIETFLEAIVRAWLAVSDVEMQDIMLSSHTATESMQHSFLRERRLLFQSFAAPALSTEATTKPDSLLDRNTGNVLDTGTSKDRDDAMTAPTDTHSNEADASSMLEVRPTNGSTSFIPASQPTSTITLVHTPTESSVPACLWRKLASKNNMDSLLITEPAEVLLLPIQHTSVSSPFSIDMTVHLDPFLWEKRRGERVDGDASAKQAEALEQELANLDAKRTLYCESNPGPMLSLLQQAETHLTNVAQSDALAQWLRRVREALEHRIQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q689</accession>
    <name>A8Q689_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729899.1">
        <property type="nucleotide sequence ID" value="XM_001729847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q689"/>
    <dbReference type="STRING" id="425265.A8Q689"/>
    <dbReference type="GeneID" id="5854206"/>
    <dbReference type="KEGG" id="mgl:MGL_2885"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2885"/>
    <dbReference type="InParanoid" id="A8Q689"/>
    <dbReference type="OMA" id="CASDYKN"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="318" mass="35992" checksum="37DD57C98FB4F411" modified="2008-01-15" version="1">MPVETHPPPYMTLNTGAKVSMVGLGCYSPDDPKQIIDGIRAATKDGYTHFDTASFYENEEVVGEGLRQSGVPREKLFVTTKLYNFDHHNVEEAFDKSFAKLNVEYIDMYLMHWPQATKPGHHFIADDTIDFVQTWKAMEKLFETRPGKIKGIGVSNFSIKTLTELLKHAKIVPAMNEIETHPYNQDPELLEFCREKGIVVSAYTPLGQAGSPILKDQDIISIANEIGDDVTPAKVVLSWNVQRGVIILPKSSNPVRVKQNAELITLSEDHMQRINNISKDPARRQRFALTYDNKTQTVFGWTFEQLGWEKPAHMSTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6K4</accession>
    <name>A8Q6K4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730007.1">
        <property type="nucleotide sequence ID" value="XM_001729955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6K4"/>
    <dbReference type="STRING" id="425265.A8Q6K4"/>
    <dbReference type="GeneID" id="5854314"/>
    <dbReference type="KEGG" id="mgl:MGL_2993"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2993"/>
    <dbReference type="InParanoid" id="A8Q6K4"/>
    <dbReference type="OMA" id="GGFKKHN"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="394"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="495"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="568"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="638" mass="66998" checksum="151D98D3C755F516" modified="2008-01-15" version="1">MKLEKGTDHEKKKPREPEPMEEDDESDESKSSSESSSESSSESSSESSSEASSESSSEASSESSSEASSESSSESSSESSSESSSESLSESSSESSSESSSESSSESLSESSSESSSEASSESSSESSSEASSESSSRSSDGPDDDSDGSSDSGSEDSDSKSSDSDTDEDSQNESNVKKPAKNKSDEDDSDDSSSSDNGSDDESDSEDSDNEEADSKKPKETEDSSEDSDESDSDSDEDSSDEDSDSSDEDSDNDESTNKDKKSDKKDSSSSDDSESESDSSSESESDSEESKTTKESESDSTESDSSNSDSESDSESDSNSDSNSSDSDSDSSSESDSVSESDSGSDSESDDEEEVAAAKDSKKRKADAEPASSTKKSKTDSNENPTHDNGIKTLWVGQLSWNVDNDWLKSEFEQYGTVLDARVQCDRDSGRSRGFGYVDFATSAEALRASKEAHGKELDGRALRVDLQPARGPQDRAESRAKHFKDERSAPSNTLFIGGLAWALTEDDIWNAFAEFGEVTGVRLPKEIDSGRPKGFGYVEFVSQDNAAKALETMNGQALGGRPIRIDFAGKRDGNNASRGGSSASGPSGRGGARAGGRPRDSGWGARAGGGARSASGSSRSGAIAQSTGKKMTFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6S3</accession>
    <name>A8Q6S3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730057.1">
        <property type="nucleotide sequence ID" value="XM_001730005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6S3"/>
    <dbReference type="STRING" id="425265.A8Q6S3"/>
    <dbReference type="GeneID" id="5854364"/>
    <dbReference type="KEGG" id="mgl:MGL_3043"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3043"/>
    <dbReference type="InParanoid" id="A8Q6S3"/>
    <dbReference type="OrthoDB" id="3261066at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="94" mass="11053" checksum="37B277FD097BB6BB" modified="2008-01-15" version="1">MSRPCHFDTPPSSSPTPMAKLHRDTRSTYQRLRFDMDSGGRFLVAGDEHGLIRVWTWSSIFAHGRESMHAIKPIYEWRAHNGMFDYLITFFIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6T1</accession>
    <name>A8Q6T1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730062.1">
        <property type="nucleotide sequence ID" value="XM_001730010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6T1"/>
    <dbReference type="FunCoup" id="A8Q6T1">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6T1"/>
    <dbReference type="GeneID" id="5854369"/>
    <dbReference type="KEGG" id="mgl:MGL_3048"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3048"/>
    <dbReference type="InParanoid" id="A8Q6T1"/>
    <dbReference type="OMA" id="AAYHKVQ"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="191" mass="21514" checksum="F11AD4961CF7B5DB" modified="2008-01-15" version="1">MATVNQKIFRTANAPAGAPSEAETTVCQALIDLESHIPELKMELRPLQVSAVKEVDVKGGKKAYVIFVPMPQLKAFHKIQLRLTRELEKKFSDHHVVFIGQRRILSKPSSHSRAKQPRPRSRTLTWVHNAILEDLVFPTEITAKSLRVSTDGSKLVRCSLDSKDATSLEYKLETFSSVYRKLTGKDVAFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6W8</accession>
    <name>A8Q6W8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730084.1">
        <property type="nucleotide sequence ID" value="XM_001730032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6W8"/>
    <dbReference type="STRING" id="425265.A8Q6W8"/>
    <dbReference type="GeneID" id="5854391"/>
    <dbReference type="KEGG" id="mgl:MGL_3070"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3070"/>
    <dbReference type="InParanoid" id="A8Q6W8"/>
    <dbReference type="OMA" id="YPNNQAQ"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="357" mass="38816" checksum="CA453FBFD1B993F9" modified="2008-01-15" version="1">MRQHRGTLVCVVLKGKHLVLKRVQDSQDPVAEVCVDGVRLRTLPDRRAGTSPLWDEQMHFEIYEDDDSDIDALHPLSEHDYRTALPSTGSLPKVHTLELICYATDKEPDYIGHATLDLSTALSRGEHDQWLILTNQGRVTGQVYVELTYYMLELPPKRASYQVSPRYTPPPPPPPPPPLSAASTPKPISPLHARTVSLDDTRFPFHRSIPSVPQPPRRPQHSRVASDAHAAMIAAQALSSPRREQYRTMSAHELIYGPACSAGLGPTNPTSPASPAAPAGPSGQHRRPLPQTPDKASMPTSLSLPALHGSPTSMSSTPTPPKARVRFVAPIPPLISTSMTSPHSPTSSSSSTPRPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7K4</accession>
    <name>A8Q7K4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729536.1">
        <property type="nucleotide sequence ID" value="XM_001729484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7K4"/>
    <dbReference type="FunCoup" id="A8Q7K4">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7K4"/>
    <dbReference type="GeneID" id="5853842"/>
    <dbReference type="KEGG" id="mgl:MGL_3080"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3080"/>
    <dbReference type="InParanoid" id="A8Q7K4"/>
    <dbReference type="OMA" id="MHERNER"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="4">
        <location>
            <begin position="70"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="3">
        <location>
            <begin position="513"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="2">
        <location>
            <begin position="696"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="917" mass="104778" checksum="8E3DA62E1BD85EC0" modified="2008-01-15" version="1">MHERNERVDAFVQALHTAADRDKKPLVRLTHFTLPPSAEDPDEHDIVSWKAQEFAYRQFSQDPDDLPTLARGLFTERMRDEVGEYERILIRGYDKFFNQGELPWTKPEVISTFSTGPYVLSFKENGCIIFLSAVTPKRLLVTSKHSLGLEFEEDKPSHAEMGRSWVQRHLAKCQRTEEDLAAELWDRDETAVLELCDDSFEEHVLPYPPERTGLHLHGLNKNSIDFMTRPMEEVNAFAKSWGFIPVRFLTFDTYAEVEAFAKEVAATGSLHDEPIEGFVVRTSMPSEMPSCPDGMVAPPYHPCQTWFYKIKFDEPYLMYRDWRELTRTMLRDKSHWDAAQIVALRSAAQNMNVNDQESQDHEAEKDEEQDKETSPQADETSLLNAPSKNALKRAKAKLKREMKRKDDAKAAADRAAGLSQPYPPTPRSRRPETLLYIQWCYDRLYGNSDKNIIPEPALFAHFNEGRGIIALRDHFLAYKASEQGQMALQSLAQCRTPQTRDLRQDDRPYEKTLIVPMAVPGCGKTAICVALRHLFGWAHTQSDDVQTKRTGPGFLKNVEKELLAHNVVLADRNNHLLKHRNEMVDIVRRLSEPEKGKTGRIRLCALVWRINGLPHSEIQQVCANRIVERGDRHQCLRIETPGHFQYDTILTRFIKEGEPFQGAQSGEGSFGVADDQFDEAVWLDIHKSMRETLEQILHHLCPIMDVSMPSDPQISEALEVACTYKPSVRKPLPKMEAESDPLAVHPSSYLGVFFPVKVHMLTKQVLEKAATNELSASARSMLENIEARNRVIHDPHITLIHRQDVESGKTDQDTWDNLFKFATKHKGLHPSVDVKLSALLWNERVMAFEVGAMYCGEWGSDKPLGFREKHHVTVGTAAKGINPFEANELWNEHAHAQRIDIDMVPIEGFLTFKSNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7V0</accession>
    <name>A8Q7V0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729586.1">
        <property type="nucleotide sequence ID" value="XM_001729534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7V0"/>
    <dbReference type="STRING" id="425265.A8Q7V0"/>
    <dbReference type="GeneID" id="5853892"/>
    <dbReference type="KEGG" id="mgl:MGL_3130"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3130"/>
    <dbReference type="InParanoid" id="A8Q7V0"/>
    <dbReference type="OMA" id="THTISYW"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="176"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="54096" checksum="998BC48FAA64B91C" modified="2008-01-15" version="1">MLLQGFEEQVLGATLPGLFLALLNTENSPSSRYTHMFFLHAHSFCSPEHLLGTFEADYLSNERDEEREHLVKILCVWIQDYWDPARDASVLDHLATLVQTTFSQHACKSVSQLRSIVTWRIRSRDLHVPDVPLDIMEFSLRIQRQGVPQLPVVSRSLMSSIQSASTVWDVDVLSFDPVELARQITLYENALFCQINALELIYPADSGSDRDSDQSTRITARPSYVRAMTHMSTQLTNWISQCILREPAVKQRTQLLRFFILLGYASYEMQNYNLLMAVLGAIGSGNILRLKQTWTGLHARKIARFHHLSRVMEPTRNFFIYRAYLRQAQGPTLPFLGLILTDITFCKDGNPIRRAFPGRSTSMINLVRLHKLSKIMDNVRSFQKPFAITPVPEIQLFLQWIRDDGRSHSHSDYMAMSEEMYQRSLELEPRLTPKSAPTRARSPSSGRNLRSWLTLKSPYDVIFSNTNGRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q800</accession>
    <name>A8Q800_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729626.1">
        <property type="nucleotide sequence ID" value="XM_001729574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q800"/>
    <dbReference type="STRING" id="425265.A8Q800"/>
    <dbReference type="GeneID" id="5853932"/>
    <dbReference type="KEGG" id="mgl:MGL_3170"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3170"/>
    <dbReference type="InParanoid" id="A8Q800"/>
    <dbReference type="OMA" id="DEASAHT"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59041" checksum="157935623342C3E6" modified="2008-01-15" version="1">MTNEPRTSQSSSTRKQDVDALLADLSLDMKSRDITRKSTSNTRPTERRQSPARPDDAQSLLDDLEGLVQRRRSMQRDTDHTQNQNSPQKSPITSQMQPAHKTRMNTSPMRPAKLGTPSPAKPASNLASPSLKNPTQESMPVSESKQRFGSTPLSVSPSPTGSGPPSSSPVSAPTKGKSAQSDAASTDSASHLSPQSQMVPSTTTQDDSGTSPSKSSSTSEISQLPNRKDVGGWGGWGSLFSTASKFAEQARDELGRRTAAVVQHTPTVDKGSHPEQQIYEFGNKFAQRVRGFVQDGGLEQIRDNITAAGRRGWNDIVNTVVLPMEAHDSVNVTVSHDMRGYDGIETLAFKVLSRVLSQADLDISVSRDKTTVPSLESAESEHGYDIHAAETRELGFQNAKGALRRLCEQARSSLASEANDSAACPAILRIQPYMDHLLAPGEEDDLFTSSSHQKQKQTSLSIDATPSALFFLVWWVDPKHRLSHLTQSQAVPAWWLSVSDEENQWVEQALGDVLENAISVVSQNRLAMFAHAASHAAANQASTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q893</accession>
    <name>A8Q893_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729684.1">
        <property type="nucleotide sequence ID" value="XM_001729632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q893"/>
    <dbReference type="STRING" id="425265.A8Q893"/>
    <dbReference type="GeneID" id="5853990"/>
    <dbReference type="KEGG" id="mgl:MGL_3228"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3228"/>
    <dbReference type="InParanoid" id="A8Q893"/>
    <dbReference type="OMA" id="RRRIAWN"/>
    <dbReference type="OrthoDB" id="3366300at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="222" mass="23857" checksum="74A78A5C0D8C1D42" modified="2008-01-15" version="1">MMHIDGVPSGMDEFVDSVFLWLRCALSIVFVCNLLEALITYFLCVHRRQTVPTTGTASIPATEVGKALARRVSQASIRGIDSSEPEKAALSAARASVTPTPSTTSASTFQMSPVTPVPGASVLRRSVSPVARSSPDAVRTSSPFRMSTMGLGRPTSTPFLNRSVTPSRPRLPSSPYTPRTAGRPSLSPNASITRHWSPTSVRSEHDDAREVERALQGLDRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8L3</accession>
    <name>A8Q8L3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vesicular-fusion protein SEC17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729747.1">
        <property type="nucleotide sequence ID" value="XM_001729695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8L3"/>
    <dbReference type="FunCoup" id="A8Q8L3">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8L3"/>
    <dbReference type="GeneID" id="5854053"/>
    <dbReference type="KEGG" id="mgl:MGL_3291"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3291"/>
    <dbReference type="InParanoid" id="A8Q8L3"/>
    <dbReference type="OMA" id="WSVKEYL"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32241" checksum="05A42D3F0DA3E209" modified="2008-01-15" version="1">MGGPSAEELLKRAEKKASSTGGWFTSKQSKLEEAVELFKEAANKLRAENRMEDAGRVLVKTAELEIETNERDFAANTYFEASKCYRMVRPDQAVIALGRCSDLLVERGRFRQAADRQKNMAELYREDPSRLDQGLEAYERAAHWYIQEGATATASACQREAAQLAIQLQQYPRAIELWEAVATSSLNSNLTKYSVKEYYLNAGLSYLAIPDHGAATRAMAFYAQQDPSFPSTTEAQFLHGVLEACEHSDLDAFDARVRDFDRLKPITGWRATLLHSVRNTVADGPDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8V4</accession>
    <name>A8Q8V4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729306.1">
        <property type="nucleotide sequence ID" value="XM_001729254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8V4"/>
    <dbReference type="FunCoup" id="A8Q8V4">
        <property type="interactions" value="586"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8V4"/>
    <dbReference type="GeneID" id="5853618"/>
    <dbReference type="KEGG" id="mgl:MGL_3341"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3341"/>
    <dbReference type="InParanoid" id="A8Q8V4"/>
    <dbReference type="OMA" id="LKYHHSP"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="4">
        <location>
            <begin position="201"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="52196" checksum="A56B7FC608906763" modified="2008-01-15" version="1">MPYHRLGASSFLRKAALPLVRQRAYATGAAATDPVQITTLPNQVRVATEATPGHFSAVGVYIDAGSRYERPWVPGESGVSHLLDRMAFKSTKGRTAEDMEQLIQAVGGNVMCSSSRETIMYQSSVFNQDIRTVLDVFADTIQNPVMDANELGVQREATAWEVSEIWSKPEMILPEIVHAVAYQNNTLGHPLLCPMENLDIVTTDNLRDFMRAWYRPERLVVAGVGMSHADMVAQATELFGGMRAAPQDPVLDMLGKERARYTGGELFMPDPSTEFTHVYVAYEGMSIHDDDIYTLATMQMLIGGGGSFSAGGPGKGMYSRLYTNVLNQFHAVDHCASFHHCYADSGLFGISASVHPSFSSTIPYVIARELELCTSGNYRGSVTKAELARAKNQLKSSLMMALESRLVEVEDLGRQVLVHGKKVSVQEMCAAIDRVDLAALHRVARRVLMNGKPSTVVVQGELDGLGDIRALLSSRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8W7</accession>
    <name>A8Q8W7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3354</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729319.1">
        <property type="nucleotide sequence ID" value="XM_001729267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8W7"/>
    <dbReference type="FunCoup" id="A8Q8W7">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8W7"/>
    <dbReference type="GeneID" id="5853626"/>
    <dbReference type="KEGG" id="mgl:MGL_3354"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3354"/>
    <dbReference type="InParanoid" id="A8Q8W7"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="255"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="723" mass="80600" checksum="63EACDF6CD15A6E3" modified="2008-01-15" version="1">MSESILAALSSLSIQAGEPRTASHAAASSQGEWTDVLAALPESTKPANYRLLKTLVFKPKTAKSETPVPVMVVTDEATQCNTSAIGSHLKLKELRLAVPELLQATLGATKDDVSPFSVTKENAGKLRVLVDQDMVESGVMYAVHARSSSETVFVTGSVLAAYLSGVGASIETVAFSTLSVPNAEASAGSRAAGGAKPESKSKQDAKIQDAELIGITVRKNLDFPEWYQQVLRKGDMLDYYDVSGCYILKPWSYYVWESIQRFFDAEIKKIGVQNCSFPMFVSSDVLEREKDHVEGFAPEVAWVTKAGKSDLEKPVAIRPTSETVMYPYYAKWIQSHRDLPLRLNQWNSVVRWEFKHPQPFLRTREFLWQEGHTAHLHKEQADEEVRYILDLYRRVYEELLALPVVPGVKSEKEKFAGGLYTTTVEGYVPTTGRGVQGGTSHSLGQNFSRMFDITVQDPKATDETRGKPEGRLFVWQNSWGLSTRTIGVMVMVHGDDKGLVMPPRVSQVQVVLVPCGLGVKVSQDVKDAVNKTCDDVAEQLRTRGIRAHADLRDNYNPGFKFNDWELRGVPLRLEVGPKDLSNQSLIAVRRDTGAKESLALNSLDQSVPMLLDQIHNDMFRKADAEFRDHRKVVLTWEEFTPTLNEKNHVIIPWCQVEECEDQIKDRSARIALAGEAQDERAPSMGAKSLCIPFDQTPYPPIEGHTCPQCGRPSKTWTMFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8X9</accession>
    <name>A8Q8X9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cut8/STS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729330.1">
        <property type="nucleotide sequence ID" value="XM_001729278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8X9"/>
    <dbReference type="STRING" id="425265.A8Q8X9"/>
    <dbReference type="GeneID" id="5853637"/>
    <dbReference type="KEGG" id="mgl:MGL_3365"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3365"/>
    <dbReference type="InParanoid" id="A8Q8X9"/>
    <dbReference type="OMA" id="KDAYPYS"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="461" mass="49558" checksum="D835AA8EF920F80C" modified="2008-01-15" version="1">MSSTPLLPPQRPHHPTSWRMSDNPSTAATVSAPLSSSSPSFSTVQAPPPPPTIPFNSASSTFQVSPALSFGFGCGISSMNSSPSDHSGSHASALRHVGAPMAAPPEQSSSSHAAGESPVRLVSSFGEHRHGANKRRRSFSSDDDTLDKAGADTQDELTKRRRGSVYERGLLNDVDAGPSTAKDALKSRDLGRLLASFDKQALLSLLLDLAKQDGMADRIYTLLPTPSVDHAVSALQAYEARIRTALPTSTSVTVRDQYVWSRVRTVLSELVSELACLVPLFSILPRRDDAEPPHPSTTFAFLQGATSCMLRIARMLPPDPVSFKHVRASSLLKTYQQSLSSAPDVRDLLAHTIFPMLLREWQAWLDAIDVAVNEHARMFGQEAILAWERGMASLGSSTSPSHGSTEQAMRAVMDDAAAHMHSSIGWLAASAHRTSWLYTPSSSSLPAYGASNMSAMDMGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8Y4</accession>
    <name>A8Q8Y4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729334.1">
        <property type="nucleotide sequence ID" value="XM_001729282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8Y4"/>
    <dbReference type="STRING" id="425265.A8Q8Y4"/>
    <dbReference type="GeneID" id="5853641"/>
    <dbReference type="KEGG" id="mgl:MGL_3369"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3369"/>
    <dbReference type="InParanoid" id="A8Q8Y4"/>
    <dbReference type="OMA" id="TFIDFTI"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="213" mass="23623" checksum="577A82554396598F" modified="2008-01-15" version="1">MASGGRGGRGGGAGALKPIGLTYIEGAQLDEVYTQSDISAAPVFEPPTEEEREIAALQLDVIRRQWDSPYWTQYTSKHSGDEPLLRYTDRYQPDRRGAASTASFLQQVRLQQAVFPPHLWDSFTSSETRRMTRQMAPTSVRAANIDWDNLHLEEKKTGGEGEDELPPDSDEDDLGNYEDEEDDDYAQNYFDNGEDDDDMGGDGGGDGDEAAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q917</accession>
    <name>A8Q917_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729356.1">
        <property type="nucleotide sequence ID" value="XM_001729304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q917"/>
    <dbReference type="FunCoup" id="A8Q917">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q917"/>
    <dbReference type="GeneID" id="5853663"/>
    <dbReference type="KEGG" id="mgl:MGL_3391"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3391"/>
    <dbReference type="InParanoid" id="A8Q917"/>
    <dbReference type="OMA" id="EAERWCV"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="475" mass="53015" checksum="6D365E4363A7304E" modified="2008-01-15" version="1">MSTSAPTQELHFVIGGAGFLGSHILRALVARGESAVASCDIREPQEPVMNVHYYEGDLTKVESLGKAIADAKQDTRDLDPESRSVVVYHTASPVAGLGPDVYERVNVLGTENVIEVCKNPEFGISKLIFTSSAGVVFNGYDLKFVDERVGYPEQPLDAYNDTKARAEEMVLKANDPNGLKTIALRPAGIFGPGDRQALPGFFKVLENKRTKWQIGQNNNLFDWTYVGNVAHAHLLASDCLGVNSPMPRPAYKFQTKELIDKHLPLKMGMTDEDHARAVPTSIKRQDVAKPATDYCRSVKPLIDLSGVDMVDIRPVFRNRFDPFFHHVNPRLACGGNPQPKLKSFAKSELQADGEAFFITNGQPIPFWDFPRALWYHYNGHVDSPESIVVLSLTFALILACLAELFSKLTGRPVQFTRYRVTYTACDRYYNIEKARRILGYEPIYGLEDSIKRSVDWWKSLHPPAKSLPGETAKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9A6</accession>
    <name>A8Q9A6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729410.1">
        <property type="nucleotide sequence ID" value="XM_001729358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9A6"/>
    <dbReference type="STRING" id="425265.A8Q9A6"/>
    <dbReference type="GeneID" id="5853717"/>
    <dbReference type="KEGG" id="mgl:MGL_3445"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3445"/>
    <dbReference type="InParanoid" id="A8Q9A6"/>
    <dbReference type="OMA" id="RRTWTEK"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="416"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="525" mass="58514" checksum="0659ED05F5437CA8" modified="2008-01-15" version="1">MSRIEKGTQRFRPAVAIGKRSSQTEKANDSAAPRPAPINVPSRTRIDTPSRSASSMRILPGQRRETAGTIASGSNSGAGSSSNIQSISTRTPTQVQQPSSQSAPSTSSGIPSSGTARSYAFSSQPPKIRVPIQPRRQVRDSSPSESSKRALNRGASTLSPYERFLHAAQADPLRILQMDVDSDPSAIAEKAAEAWQCLDPAVRADYGAPGTTLESTASTTQTRIRGPRKRTNNSISDDEAEYQRQCAQDESGTMSMDADLPPMRVDIGTTRMESIAVTNWRSGRASSRTFELERIRARQLKKRRDEALGQQQIQDGERTMSQSAEGQTHGNESMKSSETPTPSDTPRETPAPDVEPQFGENRFAVQTRIVDGKIVLDEQSLFANYRDDEQQEREQRNWEVIDERESDQFINSATRGKQRRTQRWTGEETERFFHAISQWGTDFEMITRLFPRRTRREIKAKWTRESRQNPQRLDDAFQRRTAVDLNAYGQAAGVDLSGPPPVITPRTETKADVNEEVIEEDSNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9X1</accession>
    <name>A8Q9X1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729097.1">
        <property type="nucleotide sequence ID" value="XM_001729045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9X1"/>
    <dbReference type="GeneID" id="5853404"/>
    <dbReference type="KEGG" id="mgl:MGL_3564"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3564"/>
    <dbReference type="InParanoid" id="A8Q9X1"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728028" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="62" mass="7089" checksum="B2B1EC70D20CFDED" modified="2008-01-15" version="1">MLTIFVLLYILAFQETLPRVLAKFITQPGIVIPRFNETFRDKSIDVADGYIFLSPRVSGLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA53</accession>
    <name>A8QA53_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3612</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729145.1">
        <property type="nucleotide sequence ID" value="XM_001729093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA53"/>
    <dbReference type="FunCoup" id="A8QA53">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA53"/>
    <dbReference type="GeneID" id="5853451"/>
    <dbReference type="KEGG" id="mgl:MGL_3612"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3612"/>
    <dbReference type="InParanoid" id="A8QA53"/>
    <dbReference type="OMA" id="TWLTGKH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="179" mass="19090" checksum="449476ADDB1DD894" modified="2008-01-15" version="1">MAIVPSAVRQFSASTRNMSNVFFDITKNGAPLGTIKFKLFDDVVPKTAANFRALCTGEKGFGYAGSHFHRVIPDFMLQGGDFTAGNGTGGKSIYGQKFADENFQLKHSKPGLLSMANAGPNTNGSQFFITTVVTSWLDGKHVVFGEVVDGMNVVKAIEAEGTSSGKPRSRIEIAKCGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAB8</accession>
    <name>A8QAB8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA replication complex GINS protein psf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729210.1">
        <property type="nucleotide sequence ID" value="XM_001729158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAB8"/>
    <dbReference type="STRING" id="425265.A8QAB8"/>
    <dbReference type="GeneID" id="5853516"/>
    <dbReference type="KEGG" id="mgl:MGL_3677"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3677"/>
    <dbReference type="InParanoid" id="A8QAB8"/>
    <dbReference type="OMA" id="EMINPAH"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="119" mass="13094" checksum="FCD26E596C218346" modified="2008-01-15" version="1">MSLPFAPLPLHYVAIAKLLLEHAAEDIPHSSRIRALLKDLREARQSKVQAGLEMINPAHLEMTNISSMEICELRPLFATALAQLHAVQKTEAASMQLMSAPQASESNAQDNDDIAIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAG0</accession>
    <name>A8QAG0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729252.1">
        <property type="nucleotide sequence ID" value="XM_001729200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAG0"/>
    <dbReference type="FunCoup" id="A8QAG0">
        <property type="interactions" value="761"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAG0"/>
    <dbReference type="GeneID" id="5853558"/>
    <dbReference type="KEGG" id="mgl:MGL_3719"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3719"/>
    <dbReference type="InParanoid" id="A8QAG0"/>
    <dbReference type="OMA" id="AIMRENQ"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="301" mass="32331" checksum="08D2F9E1350F6485" modified="2008-01-15" version="1">MDPVYANDTSGCTAVAALIVPEPGSKGRRMYVANAGDSRCVLGLAGKAKPMSHDHKPGNAEEHARILNAGGFVEFDRVNGNLALSRAIGDFEFKQNASLPPEKQIVTADPEVLSHSWTGEEEFLVLACDGIWDCLSNQQVIDIVRRGIAEGKALDVITEELIDRCLAPDAEVGGIGCDNMTLLIVALLGDRTKEEWYQWVKSRVDDKVGHETPESVPPVFRSHGQQQHQASSTMLGGAAANAQHNVTMSLNGLSGSDILSAIPRVLSGQAAHEDFDIQNADDNDDHGRIVSADEDEAPSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAK9</accession>
    <name>A8QAK9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728980.1">
        <property type="nucleotide sequence ID" value="XM_001728928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAK9"/>
    <dbReference type="FunCoup" id="A8QAK9">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAK9"/>
    <dbReference type="GeneID" id="5853287"/>
    <dbReference type="KEGG" id="mgl:MGL_3768"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3768"/>
    <dbReference type="InParanoid" id="A8QAK9"/>
    <dbReference type="OMA" id="KPHNETT"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16505" checksum="4C218D6CE6858838" modified="2008-01-15" version="1">MGIESAAAERKARIAALRALRQAEEAGDQAAIDANAFGRQVKQHFRTSRPPPAGMLASASAQAPMTLEQEVDGMQEQVIQEDTRKQAEELDLTNIAPRRANWDLRRDLDERLARLEPKTQAAIHTLIVQRIRASRDRDEEAANVLVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBD1</accession>
    <name>A8QBD1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728907.1">
        <property type="nucleotide sequence ID" value="XM_001728855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBD1"/>
    <dbReference type="GeneID" id="5853213"/>
    <dbReference type="KEGG" id="mgl:MGL_3901"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3901"/>
    <dbReference type="InParanoid" id="A8QBD1"/>
    <dbReference type="OMA" id="ETEHIPT"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="320" mass="35080" checksum="CC0214424224BCD7" modified="2008-01-15" version="1">MVALAKLTNVTSTPYECPTIESQQASESWRSLLPTDGPKDPPTQKGMSTLSIPTQREYDPESWRSLIAGHVETSEPQNIFLDPNDITGHSESSHIDDNEEISPVFGRRADLFVRRPSPSLSVHAPLDKLRSRQSVTDPGPFSSSPKHFDMTDYASHANDKLQRHSTDASFDGIETLEGARADVNAELSLSTTSCDFGNDRESWPTSSRQGAHLSGSSQWPPMATPRPVSARVVSELDRSFSDPMDMLSKENLPNISTGAPTSAVQIHKPSLSQIDTTRPSSPQTKESTSHTLGKSHDDRITVSTSHDAYTVVNVYAWIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBM9</accession>
    <name>A8QBM9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728931.1">
        <property type="nucleotide sequence ID" value="XM_001728879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBM9"/>
    <dbReference type="STRING" id="425265.A8QBM9"/>
    <dbReference type="GeneID" id="5853237"/>
    <dbReference type="KEGG" id="mgl:MGL_3925"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3925"/>
    <dbReference type="InParanoid" id="A8QBM9"/>
    <dbReference type="OMA" id="YASHAPN"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="41091" checksum="74A6FC3F30EC7317" modified="2008-01-15" version="1">MGRSITPRPVSLANRPSNEVAAKRRGWVRRRSKDTPSHLGLVSQNVKTYIYAIWRVTIVWPLLCIYRVTYALFLSRTSHRVILRILMLCGLHMTCMAMALLAFGGFYYAWVPQVELSKDVWLQYGNDAPWAEVLLDSFPSDPPVWQKEARVPMFEKDQMYDVSLGLRIPVNQVNKEMGNFMVELSLVTSDGIILYESFRPVLLVPDPWAVRWTSRFWRMLWKPIFSEPVAPTQLVQVPLLRRIVPYASHAPNAPVVFRQKGYLASHAIVRIGRASNVEKNTSKQLENSTYTPVTLHPSVVQIEHATLCFNAFLSGASYLMYEYPIISLGVFFVFFSSIEVTVAGSIWLVTSAYMSWGMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBP8</accession>
    <name>A8QBP8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728936.1">
        <property type="nucleotide sequence ID" value="XM_001728884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBP8"/>
    <dbReference type="FunCoup" id="A8QBP8">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBP8"/>
    <dbReference type="GeneID" id="5853242"/>
    <dbReference type="KEGG" id="mgl:MGL_3930"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3930"/>
    <dbReference type="InParanoid" id="A8QBP8"/>
    <dbReference type="OMA" id="YAGKQMA"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="70" mass="7896" checksum="56C5E757D79D1371" modified="2008-01-15" version="1">MLIKVKTLTGKEIELDVDATDKILRIKERVEEKEGIPPVQQRLIFGGKQMSDEKMIKDFGIEGGTVLHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBY5</accession>
    <name>A8QBY5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728959.1">
        <property type="nucleotide sequence ID" value="XM_001728907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBY5"/>
    <dbReference type="FunCoup" id="A8QBY5">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBY5"/>
    <dbReference type="GeneID" id="5853265"/>
    <dbReference type="KEGG" id="mgl:MGL_3953"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3953"/>
    <dbReference type="InParanoid" id="A8QBY5"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000449">
        <property type="entry name" value="Ubiquitin-activating enzyme (E1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="3">
        <location>
            <begin position="96"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="530" mass="59078" checksum="1B6A47823DC17B73" modified="2008-01-15" version="1">MTGASAVLPAHGLSARLAVMLGAVALGSSLLSIATILGFQRQVRRRRKRALKKEAAQHPPSSDAHIPENRVNAASHSKLEASRGSYDESLIREQLSRNYSFLGEEGMKTIRDSFVIVVGAGGVGSWTALMLLRSGVGHIRIIDFDQVSLSSLNRHACATLADVGRPKVVCCQQYFHRVAPWADIEAYVDLFRESDADRLLAGSPTYVVDAIDNLDTKVELIKYCALRRIKVFSSMGAGAKADPSRVQISDISTTAEDPLARVVRRELRVAGIPLIPPSGSDESKMSAKTSIDSNNETSWTIPCVYSTEKSSTHLLPLPDEEFEKGAVNELAAFEDFRVRILPVLGPIPAMFGLAAATYILCDLAKYKLEPLPIKGRRKLYEKLFADLNVTESRYPSPPVDERTHTLPSNRRPLTDDDVPPNYHMVNEKGPPPRVRIPFSVNDIAYLFEEVFRGRTVVPPFETLSTGQFQRWDPRLPLDYNNVVLFTRPQARRHEQHVLSCNADPTTYWGPVVSTKVQQRIKEELRMSHWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCK2</accession>
    <name>A8QCK2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728851.1">
        <property type="nucleotide sequence ID" value="XM_001728799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCK2"/>
    <dbReference type="GeneID" id="5853157"/>
    <dbReference type="KEGG" id="mgl:MGL_4018"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4018"/>
    <dbReference type="InParanoid" id="A8QCK2"/>
    <dbReference type="OMA" id="HTENMPR"/>
    <dbReference type="OrthoDB" id="683469at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973:SF187">
        <property type="entry name" value="MUTATOR TRANSPOSASE MUDRA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973">
        <property type="entry name" value="POLYPROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="439"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="638" mass="69335" checksum="910E78CB19284F18" modified="2008-01-15" version="1">MTNPAISSAILESVSVGGVGSDAQHLAPHVAAVPSPSLDAVSIKVGDLFPDMKSFRARLGLYGITHKCPYRARRSDNSRFVGICPAVMNDLKKEWGKGKNKAPHHEPAALNEHAIPCPFHVIARRRKEGGVCVTRAILMHSPDCTAPVSFSTSATSAYMSQLMEESASTIAPREIGKFVHEATGTKLSYSTLWRTSHMLQSKERERLDASFKKIVPFLNAFREANANTTAVVEQHANGRFYRAFLCPGALGHALADCPFALHVESMPITSCYEGFVLAAYVKDGLGAPLPLAIAITPRADEDNWRFLFHQLLSALPIVGCSGIAISHDKDLAIHEAQLSVLPASQSVLQFTHFDWTASGTLQEYYNQMSNLCASSYFSIIVGWVTQVAVLMYARYVELESERSVFPGELLGRGNVHFDGWDVASFGPSDYLVVNPHEKQQVNLAIRTCTCGQWADHAFPCIHAIRCLPLERLVSLGQFIHPSYFTESVRRCYSRRMTLINTSTLVGQGETLPNTAAFMSEHNTTAGSVTMPTELPLLPPSGTEPVKRGRGRPRVVRSNSHRGSGLGAMYQCGHCNGKGHNSRTCPMNQKPEVAVPPTTAQITAVALGGPSTESAPNMFADATVPFTIDSSLSTSQTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCX3</accession>
    <name>A8QCX3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_4056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000019">
        <property type="protein sequence ID" value="EDP41591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728805.1">
        <property type="nucleotide sequence ID" value="XM_001728753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCX3"/>
    <dbReference type="GeneID" id="5853113"/>
    <dbReference type="KEGG" id="mgl:MGL_4056"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4056"/>
    <dbReference type="InParanoid" id="A8QCX3"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="110" mass="12402" checksum="2884DBAAD4ABBF08" modified="2008-01-15" version="1">MHGTKSQVVHRAYGTDGKKPQVPKVEEQENPVRRDTVAVDGFGSVTIRFVASNPGAWFMHCHMDWHLSAGLAMEMVQAPEKAKEVLKVPSYVEEQCKVWKKQSDQKLRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD50</accession>
    <name>A8QD50_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728783.1">
        <property type="nucleotide sequence ID" value="XM_001728731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD50"/>
    <dbReference type="FunCoup" id="A8QD50">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD50"/>
    <dbReference type="GeneID" id="5853046"/>
    <dbReference type="KEGG" id="mgl:MGL_4118"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4118"/>
    <dbReference type="InParanoid" id="A8QD50"/>
    <dbReference type="OMA" id="LEWDLCS"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="683" mass="75022" checksum="80FFE828FDFCC8F3" modified="2008-01-15" version="1">MDATRSTSAPYHRGASLVSNVAGPALANGAWVLGTSSAPLRLQSRIAPSQAKYSTYASRMRAGTTTLMQPIQRSANELDGTSVLGTRSARQSVYYGEDESDDDDEESEYEDEEFSSSQRRKRRRGAHESRSASSLDTRVVDPEAEAELAAPGSQLGLPVSCDRLVVRPAKRTPHTFPTEQQLQQQSEFAEVLVPIRIEFHTNTHRIKDVFLWNLHERLITPYQFAHIFLQDLELPMQPYAVQIESLIIQQLSDAMSVLDREGDGISRILDLKSSARERKRIETEVEMQRRRAAAMLQAASASDSASPSAPRKRGRPRKHPAPESKEDSPVVPPQPQSQLLSQPPAPTQPLSQASVPVSGPTAHALPAIDNDSASKSVDKASIHDAISRIDAEDDLRVIVEYEVQISRHMLRDRLEWDLCSTLTPEAFAKTLTRDLGLPLESGVLISHAVREQLLHHRRAAMELGLFGSGKIYKCIMDELLRIDKAERALLRASASPSESGQGATGAAPSESTAATSAMMDLDPLSEDEALHQRRAISSAAMTNASDMDEWHGATLTRDDQAPPHTRSRRLAAATQYGSLSHSHDATAAFSAPSNLSSSAPFPPFPSAASIPFLVPDESLPLALRRHQALMTLRDLLAVGPRPLEGAWRDFAETSDFGPLLEYLSEAEMEKMEEADLRASRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD72</accession>
    <name>A8QD72_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA carboxyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728661.1">
        <property type="nucleotide sequence ID" value="XM_001728609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD72"/>
    <dbReference type="STRING" id="425265.A8QD72"/>
    <dbReference type="GeneID" id="5853001"/>
    <dbReference type="KEGG" id="mgl:MGL_4140"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4140"/>
    <dbReference type="InParanoid" id="A8QD72"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="267" mass="29712" checksum="B67A8E5FDD2E6DCD" modified="2008-01-15" version="1">MLANWRGFSGGQQDMYDEILKQGSKIVDGLAQYHQPVFVHIPPAGELRGGSWVVLDAQVNARGMIEMSADSDSARGGVLEASGLVEIKFRAELQRATKMRLDPTFAHLTHAVHAAAPSDKPALMQRLQEREKHIAPFFHAMAVEYADAHDRAGRMLATGVLKCAMPWAATRRYFYWRCRRRLIEARYQHALADAIPFLQPRDCLARIEAAASYVSTDADEFAVRQLESHLSHLDAAVEHARADAMLEALSALSPGARERILSILQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDG6</accession>
    <name>A8QDG6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycoside hydrolase family 43 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000022">
        <property type="protein sequence ID" value="EDP41428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728642.1">
        <property type="nucleotide sequence ID" value="XM_001728590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDG6"/>
    <dbReference type="STRING" id="425265.A8QDG6"/>
    <dbReference type="GeneID" id="5852967"/>
    <dbReference type="KEGG" id="mgl:MGL_4203"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4203"/>
    <dbReference type="InParanoid" id="A8QDG6"/>
    <dbReference type="OMA" id="WGVFHAT"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18820">
        <property type="entry name" value="GH43_LbAraf43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36588" checksum="43EC04D2E98DE843" modified="2008-01-15" version="1">MSCRPIANVDMPDPWVYAWNGLYYLTFTLGDRIEIWASNNIEDFNNPQKSLVWRPQGSGWAPGIWAPELHNINGIWYIYFSGEKPGEGPASHRTLILRSQSQDPMDPQGWQFIGPLQGVPDHWAIDATVFSLGQNLYCCYSGWPLADNSDTEQDLFLVQLVTPEQAIPETLVTISKPTEKWERPDGGKRGINEGPSFVDFQGIRGIVYSAHGSWTCDYKLGLLNLTGSNPLDPKSWTKRNSPLLSSDRSKGGPYGPGHASFVPTNDGRILCMFHCTFNVDDGWENRKARVMCLNAQDFSPSADCCCCATGETPGDRPGGLLGKIINAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDP9</accession>
    <name>A8QDP9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_4226</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="AAYY01000023">
        <property type="protein sequence ID" value="EDP41413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728627.1">
        <property type="nucleotide sequence ID" value="XM_001728575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDP9"/>
    <dbReference type="STRING" id="425265.A8QDP9"/>
    <dbReference type="GeneID" id="5852944"/>
    <dbReference type="KEGG" id="mgl:MGL_4226"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4226"/>
    <dbReference type="InParanoid" id="A8QDP9"/>
    <dbReference type="OMA" id="GHFENVQ"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="552" mass="62376" checksum="F881FE2E45042519" modified="2008-01-15" version="1">MVLSLSVDPEEYVQRAHVKESHEAVEKARSHRHRSVDIPHYTPTGRYGTKPVPKYHLPEKGLSERATYELLSNELLLDGKPSLNLASFVHTWMPDEARRLMMDTIGVNLCDQDEYPATIAIHTRCISIISNLWKAPKGHVKDGRRLAAMGTATTGSSEALMLGLLSAKRRWQNKRKEQGKDIHHPGPNLVFGANVQVCVEKFARYWDVEERPVPVDESTHYCLDPKRAMDYVDENTIAVVVILGSTYTGHYEPVEEMALELDEYQKKTGHDVPIHVDGASGAMVAPFATPDHKWSFDVPRVASINTSGHKFGMVYPGIGWIIFRSPEMVPSDLVFELHYLGSVEYSFGLNFSRPAAPMIGQMFNFISLGREGFRSTMEANLMNARLLSRALEYSGLFVVLSDIHRPAEKKVPITTEASKYCPGLPVVSFRWTDEIKREYPHMEQSWVQTLLRAKGWIVPNYELPPNLSDVQILRVVVRDSLTESMVEVLVQDIINITRHLMEQQRVAREASMDPVSTRGMTNMLLGHSYKKNNDHGRPYGQGQPPNGFKSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDU4</accession>
    <name>A8QDU4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000023">
        <property type="protein sequence ID" value="EDP41424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728638.1">
        <property type="nucleotide sequence ID" value="XM_001728586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDU4"/>
    <dbReference type="FunCoup" id="A8QDU4">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDU4"/>
    <dbReference type="GeneID" id="5852933"/>
    <dbReference type="KEGG" id="mgl:MGL_4237"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4237"/>
    <dbReference type="InParanoid" id="A8QDU4"/>
    <dbReference type="OMA" id="DYHDEDW"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="11"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="355" mass="38084" checksum="21AADF188E3B7497" modified="2008-01-15" version="1">MTGMEAVIVDGKSAASVKHVEAPKLQPRSILVRVQCIALNPTDWKHLDFYGKEGTTLGCDFMGTVIEKAPDAGSSVKVGDRVAGTVHGGWEVGVGGFAQYVVTTPEYVVAVPDSMSDEEASGLGVAGITALFGLFQNKQLGLPEPSGTELPPVDPKLKVLVWSGASSVGQFVIQMARAIGAYRRRSILDWLKSLGASELYEYSNSETPKRIAEAHPDLKYAFDTYSMNGSQAACAASMSKTEAGKIVSLLPFDHGTVTEANPMAKCTFFVLYTISGQRTQIFSADFDEEYCKEDAKYMAGVGNGKDGLFYRLLSSGLVKPNRTSPQTGGLSGILSGLDLMRHNKVSGEKLVYKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQZ4</accession>
    <name>A8PQZ4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732775.1">
        <property type="nucleotide sequence ID" value="XM_001732723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQZ4"/>
    <dbReference type="GeneID" id="5857081"/>
    <dbReference type="KEGG" id="mgl:MGL_0550"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0550"/>
    <dbReference type="InParanoid" id="A8PQZ4"/>
    <dbReference type="OMA" id="NMSGWDQ"/>
    <dbReference type="OrthoDB" id="3362813at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="281" mass="30730" checksum="D0CC0DBC07979950" modified="2008-01-15" version="1">MDAFDSGSELSSADEEVIQSEPETKRGRSASMSKAISNDAATSERRAKRPRSSLPHEESHRQSGTTSGSANPNADPNSVASETSIEVQRAKPRTASRTAQDASFAHNMSGWDQLFGPMASAATEPARPKDATPEQRAAAVEAEAAKMRETRAREAREKAKEAHERAKEAHEKAKEQERQVATAMREARARNAHNGNNNSSIGTGNGNGSSSISPLERRPQSVTADALAEKRRQLRREMHDTHSLDLLEHGRLMHAFEEEMAHDRRTLRASKLGAGLQHLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR07</accession>
    <name>A8PR07_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732788.1">
        <property type="nucleotide sequence ID" value="XM_001732736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR07"/>
    <dbReference type="FunCoup" id="A8PR07">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR07"/>
    <dbReference type="GeneID" id="5857094"/>
    <dbReference type="KEGG" id="mgl:MGL_0563"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0563"/>
    <dbReference type="InParanoid" id="A8PR07"/>
    <dbReference type="OMA" id="ILTEDMR"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="376"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="585"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="594"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="660"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="740" mass="85037" checksum="B319E4BDD9CE5694" modified="2008-01-15" version="1">MDDADRSGKRKRSDSSGDVATQFDTSQNDAASKGEALRSAMAKLAETRAGGTYVPPARLRALMEEVARADPGSIEFQRMNWEALRKSITGLVNKVAADNIKYIVPELFAGANLIRGRGLFCRSIMHAQELSLPFTPVFAALAAIINTKLPFVGELLVTRLVSQFRRSFRRNDKPKCHATLLFLAHLVNQRVVHELLALEILVLLLENPTDDSVELAVAFMRDVGAFLTEEAPKACHTVFDRFRVVLYEGDISVRVQYMVEVLAQTRKDRFQDHPRIPEELDLVEEEDQITHQISLDDELKVEEGLNIFKADPEFEANEEKYRQIKAEILGENSDGDEEDEEEEDDEPEGDDAAGDEEDDAQTQLEIQDRTETNLVNLRRTIYLVIMSSLDFEECVHKLLKLRVPDHQEMELCKMVIECCSQERTYSKFYGHIGERLCKLHRHWSGLYEQSFHTYYDTIHRYETNRLRNIARFFGALLATDSISWACFEVVHMTEDETTSSSRIFIKILLNEMQSLLGLKTLAERFREPSMQEYYRHIFPMDHPSDTRFSINFFTSIGLGVVTETMRERLKIATQLMMERREAEWARRAESEGMSSDSDGSYSRSSRSRSYSSSYSGSYTPSSRGRSYSRSLSPRGRSYSRSPSPRGHSYSQSPRPRRYSYSRSPSPRGRSYSRSPSPRGRSYTRSRSYSRSPSYSRSPSPDRAELRRLRDPYRDDHRYPSSARSQSPRRTTAMASSRYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR76</accession>
    <name>A8PR76_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732848.1">
        <property type="nucleotide sequence ID" value="XM_001732796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR76"/>
    <dbReference type="STRING" id="425265.A8PR76"/>
    <dbReference type="MEROPS" id="C02.029"/>
    <dbReference type="GeneID" id="5857154"/>
    <dbReference type="KEGG" id="mgl:MGL_0623"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0623"/>
    <dbReference type="InParanoid" id="A8PR76"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="139"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="767" mass="85382" checksum="BA2B3E0DC65D81BC" modified="2008-01-15" version="1">MPVDGTTEEARSVANRAIELERNKRFFEAFRAYVSATQLFLEAARASPETLGSDARRMASRCLERAERLRESHKLANDPCDTWEVWTQDPSLSDFARIDLHVEASPALSPLQIQQGAKLRQASPAIPIMCRDVVLRAGDIEQGSVSDCSLITAIEIATEHNARWHTRLAFEALFPQLDSMPCRSPTGVYMVKLYLHGQARCITINDALPCTLTGELLCSKPRHNIQLWPALLEKAFLVAKRSSYAFNGSDACMDLYALTGWIPEHIPLHEASFQCEKTWTRLFTAWKQGRCLLALGTGSSPETMSALVPLHCYGIIELREHQHKRTVSIVNPWKRHDVLQHVKDMAWEEVCCYFDTLLVNWDPALYPHQRQVTGMWDATSDSAVRLDEFRAAQTDQYHISVSQEMSTPILLHLERHDLSGTYEEQEYMALHVFPCNKAQRRAQVEFDGLMGMYVNVPHSLLALHASGPMQYTLAVSRHGSALYPMPYTLTVYATSLVDLAVLPPTMPNRSIVHGSWRPSPNRGVPELWYQPQYRLTVHEGTLLPRLELVVMTSLSTCVAAVLLTSGKRVLCWEEASVVAHTGTLSRGIARSDVQVLQPGAYTLVLLTSCSHDETATSSTTSAAASFSVIVESNVRVSVDILPMLGAGMYRRSAHATTLPHAWQVYVPRAMPLLICAVTDAPDHANEPATMTIRLEKHSSSLCEAESKSRTNYAVLHSQTLAPDMYTLSIDGILKTPFSSLDVDVFGSQPVSLTDCDIAPHIRIHSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR86</accession>
    <name>A8PR86_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732854.1">
        <property type="nucleotide sequence ID" value="XM_001732802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR86"/>
    <dbReference type="FunCoup" id="A8PR86">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR86"/>
    <dbReference type="GeneID" id="5857160"/>
    <dbReference type="KEGG" id="mgl:MGL_0629"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0629"/>
    <dbReference type="InParanoid" id="A8PR86"/>
    <dbReference type="OMA" id="MQARWPA"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000599">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="220"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="562" mass="61162" checksum="9BB5B58B2FF113FF" modified="2008-01-15" version="1">MDASTLQWAYRAQKSLGVKAGVPAFPDAPGFDGSHVGARMLVYSADGSRLAVALEGTTRVYDVQNHGLVLRHEVPVSRAIELAFSPRGTYLQTWERPVKAEDGTWSRNLRIWHAESGELLGEFERRQIEGWAFQFTDREDHCVRPTSAELQVFCPSDFRAGAVGRLRVENVQSFSLGPGGQPSIAAFFPEKKGMPAFVRIYSLASLLKQGEPPAAPVAQKSFFKADKVTMKWNAAGSSLLLMTSTDHDQTGKSYYGETNLYMLSARGDFDCRVGLDKEGPIHDFEWNPNSREFIVIYGYMPAKAVVFSYRVNVIAELGTQPRNLIAYNPQGRLFCLAGFGNLAGTVDIWDRERLADGKLFTLDASNSSVLEWSPDGHFLLTGTLSPRLRVENGVRIWHCTGKLVHVDMVDEMYQACWRPQKLIPHSSLPPFPKELPAAPAPSEAAAAVLAKKQAAASRPAGTYRPPSARHAGATPSDLLRRDTSDAPPSSRQAYLPPGAAASSSSTSGPGGRRGRKVPGAPEKPAAPTPKPAMGAADVGAHSSEARSRRKEAKEPDEEAQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRD9</accession>
    <name>A8PRD9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732255.1">
        <property type="nucleotide sequence ID" value="XM_001732203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRD9"/>
    <dbReference type="STRING" id="425265.A8PRD9"/>
    <dbReference type="GeneID" id="5856561"/>
    <dbReference type="KEGG" id="mgl:MGL_0030"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0030"/>
    <dbReference type="InParanoid" id="A8PRD9"/>
    <dbReference type="OMA" id="KRTVMHV"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="114"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="706"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="548"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="731" mass="80730" checksum="F79016B103751C4E" modified="2008-01-15" version="1">MEPFSQPHAQAQARTQSVPFVLSKSVSTPSPASASRTVRAKVTEGIRTSKAKSSGLTPTESDRLTCSPERPQQQLRIPDPPSPNSRIDVSTLQHELGDNSFVLESDDTHPSGESVQVHIRVRPNAEDEQCAWVASSESASLALDSALACGRMQPNADKPYYFDDVHTGSSNAHIYSALARPLVHSTLHGYNAVIFAYGQTASGKTFTLSGDEDGREPGVIPRAVQDIFNGICQGSTRREYLIRVSYLEIWNEIVRDLLEPANQPQVRDDRRRGPNAVLVAPLHEEVVTSPAHVFKLLARGESNRHTGATDWNERSSRSHTCFKITIESWDRNPANTRPYRISELSLIDLAGSERHSVNTKSRRTEGGNINKSLLSLGKVISALSEKGAGGRGGHIPYRESKLTRILQNNLNGRSRIAVVCTLNPSPAMVEESLSTLNFARRIKHVRVRAPINEYEGHVSSQGESQTLLAQYREEMGSLRAQVAELQSKKPSSRQPSTQSIPVTVETLHARLEELGALILQGGAEPPAQGTSHPVSPTKQRGFAFDDPLPVLQEKLHAALEKIRRLERQLAARMSLPMSTNASDDVKDARIQFLLQQIRELETVCEAQTLEAPQKVREDVEAEWMKRLEAAEAANKERDAFLAEISAECTRLRQANEALVRLAHEQTSSMLQELASRDTRPHVISMFMPHLRPTTVLGTQHIPAAEQDLSIDDVSSDDRLSSSELDDLLDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRI0</accession>
    <name>A8PRI0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732282.1">
        <property type="nucleotide sequence ID" value="XM_001732230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRI0"/>
    <dbReference type="STRING" id="425265.A8PRI0"/>
    <dbReference type="GeneID" id="5856588"/>
    <dbReference type="KEGG" id="mgl:MGL_0057"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0057"/>
    <dbReference type="InParanoid" id="A8PRI0"/>
    <dbReference type="OMA" id="WSERRAM"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="491" mass="56032" checksum="3286E74A9CD32864" modified="2008-01-15" version="1">MFQNNLCLRIGSYVEELHIPLHKLPTIDIPASSSKKKQAIATSELLKLLRLVLGIVLKSDNNDEQVRAMQDLSLDEQVTMKNVVEDVLANFPSPEDAHFSENNEKNSDANQYRQELNALRRDLARANERVSQYHEQLGHIESEFERATTENKELASQLASFRSLEQERNTMRDLLDEYKPMIDAYKKQERTLGKLRERAEETLELKRQVKELETKNAELVEQASDAADRSASDFAGKQRAVSLKSDRKYAQLEDQHAELVKERNVLQAQFALLEDKRHQDQIQLQSLLERVRSLEVDDTHHRDTLPDALRSSVSQVEHTQDPLPITRNVEKSHDAQLLGQVQSAQHSSRQNVGYGTLDLGTTLAAVQADITAMRNNNTSRRSEIEHLLRKLEKKWPKDAGKSSTKDIKNVSNLLADSFQHENLVLERLQHCWDQANTVSTISHPFKCTCTCVGSSALTFSNLTDYTRSRPVHSDDDRRRGMPIHVTYAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRJ5</accession>
    <name>A8PRJ5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0067</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732292.1">
        <property type="nucleotide sequence ID" value="XM_001732240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRJ5"/>
    <dbReference type="STRING" id="425265.A8PRJ5"/>
    <dbReference type="GeneID" id="5856598"/>
    <dbReference type="KEGG" id="mgl:MGL_0067"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0067"/>
    <dbReference type="InParanoid" id="A8PRJ5"/>
    <dbReference type="OMA" id="AGYTDCE"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="191" mass="20601" checksum="1063414D377554AF" modified="2008-01-15" version="1">MSSDKPHGQIASEEVLNKKMDLCLSNTIVKTGIGFSAGVVLSVLFLRRRAWPVWLGTGFGMGAGYTDCERSFNPVSVPGVRILPADTANVSAPPTRFSLLQQRVGELFGQAHEQASDAVDNTKDLRTAAHERFAELSQSGKEQIEKRFSDLQDTTQKFADKIVETGKDLTSSNGGNNSSGSGEANNKVRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRK0</accession>
    <name>A8PRK0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732295.1">
        <property type="nucleotide sequence ID" value="XM_001732243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRK0"/>
    <dbReference type="FunCoup" id="A8PRK0">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="GeneID" id="5856601"/>
    <dbReference type="KEGG" id="mgl:MGL_0070"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0070"/>
    <dbReference type="InParanoid" id="A8PRK0"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="301" mass="33056" checksum="A2F590E4AC9A32B6" modified="2008-01-15" version="1">MGAFSRALGNVPTHDVENPRTQKVVYLVLPYFPNGNVQDAINAHIVHKTRFDERKMLQLFACACDALKSMHQYVLPHVSVQAGDEDEDVNTTHAVSTKDDSLLFDAGLSESYAYPPPEPMATNAAASKPLSTSSTHAERVPYAHRDVKPGNIMISDDGNTGVLMDFGSTMRARVTISSRREAIAHQDLASVHSSMPYRAPELFDVKTDAVLDEKVDIWALGCTLYAMAYLHSPFETLSTVEQGGSIALAVMNGAYKFPPADEDPYSPHVRHIIERCLEHDPQARPDIDAVLNDVHMALASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRM1</accession>
    <name>A8PRM1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732308.1">
        <property type="nucleotide sequence ID" value="XM_001732256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRM1"/>
    <dbReference type="STRING" id="425265.A8PRM1"/>
    <dbReference type="GeneID" id="5856614"/>
    <dbReference type="KEGG" id="mgl:MGL_0083"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0083"/>
    <dbReference type="InParanoid" id="A8PRM1"/>
    <dbReference type="OMA" id="KWEKMQN"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="65"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="456"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="515"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="550" mass="59627" checksum="B80701E915D61085" modified="2008-01-15" version="1">MSENGDKSKVRLRAQFRKPRVRLNFSRHVAGATATGDGPKTRPYMQGYDRELDSEDDETGEGMAFEEQLILRVPEGPGEHGELDALRQAIRRRSEYNDVWFKFKDSRRAVFHIGQQLYAAKLVDLPCIIESHKTLDNKQIFKIADISQMLLIERPIANESEATAATHSAKSSNDEYIYPHGITPPMQWARKRRFRKRVHNRSIDTVEKEVEGLLNDDKRAERVTYEFIDPAQADQIEQDVSQQKFSAADMEHHASDDEGKQEGGASAHADGDDDGDDDDDDDDDEGAMDDDDENVDQDLAAELDAALAREQGTGGEDESASDNEDAGAGSDDDARSAQDSDLEDLWDDDDDDDDEAQAEADDDDAEPKSDKEDDDEGGEEEAERRVRESQLEAECREIESLIKRKQHDIESTMNALIKSRHQQALRKLQVEHDAKKRHLHDIKQIRRTIREERAADAAQEAANKAASAGTSTSTRTGAGSAAAPSTGPAATMPSTSSSATSIGSGSGAASGSGSGSASASTTPATGPGSGSAPKPSSGSTAATAPAPNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRW7</accession>
    <name>A8PRW7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0144</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732369.1">
        <property type="nucleotide sequence ID" value="XM_001732317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRW7"/>
    <dbReference type="STRING" id="425265.A8PRW7"/>
    <dbReference type="GeneID" id="5856675"/>
    <dbReference type="KEGG" id="mgl:MGL_0144"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0144"/>
    <dbReference type="InParanoid" id="A8PRW7"/>
    <dbReference type="OMA" id="EEKRHCC"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="324" mass="34749" checksum="0131A7EF022F5FF4" modified="2008-01-15" version="1">MLLANPAFSSMSPSSQWPGGPPNVLLPSLSSAAPSSFPLSPMSVPGMPSSSLSDFDRSLNASSLMHVPAPPPPEQERSTSIAAPTATSSLLPIESAVYSQPADTTPLDDYSRVHRVMPMPVPSVAPYSMSPMSTGGMNGGTSRHPHPAAFESSMTTTTSAVSPSSIPSTHAPAMSGATPEFVRISMSPPGVSALDMSQTSDMSGSWLSTPSRAHDSLHVRHDTVNGNGSNSSSNGRSYRSPKARPFVCSHCSRAFSRRHDLERHARVHSGDRPYVCRVCQKGFPRSDALRRHIRVERDTHESYFVSKTSDVLDMSDRDTHARHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRX3</accession>
    <name>A8PRX3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732373.1">
        <property type="nucleotide sequence ID" value="XM_001732321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRX3"/>
    <dbReference type="FunCoup" id="A8PRX3">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRX3"/>
    <dbReference type="GeneID" id="5856679"/>
    <dbReference type="KEGG" id="mgl:MGL_0148"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0148"/>
    <dbReference type="InParanoid" id="A8PRX3"/>
    <dbReference type="OMA" id="TDSAVMD"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07651">
        <property type="entry name" value="F-BAR_PombeCdc15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000045">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000312">
        <property type="entry name" value="Related to Cell division control protein 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="18"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="682"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="632"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="442"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="80339" checksum="4D076C76CCCDDC9D" modified="2008-01-15" version="1">MSVSAPYNAAAADNIDAYAFCNSFWGENDAGYHVMQSFIKNTTRTMEDLRTFYQERAEIERDYAKRLSKLAKTSLGKYETGPMRHALNTVRIETEAQSKSHSQLENSIRKEVEGPLIDFMRRVDSLRRDAQTSVTKLYKHKQSQTQYMNRAREKYETNCTKINAYTAQSNMVQGRDLDKVMAKLERVQSNIDNDDRDYESFVRALQETTQKWNSEYKSFLDICQDVEEERQDFLKTNVWGLANAISSICVTDDEACERVRVSLEGCEAARDVREFVREFATGSLIPAAPDYVNYAQNIAPPSSGTGSAHFSRLSTRVGEGMNPPSASLLATQTPATAQLSTPASARPMTPSLMTPVPPGGGLRPISPSVMGPGTPQTPASMALHSMQGPNAPNYLAAMSRTPPPQTISPAARTPPPSTSNRNSMFAPGATPLAQSQTPHLQSPMSPGSAPPSASIPAAASGPAPGPASSQPASRPVSSHISATPASDEDDPIAKALANLRMRQSRKSPASGSRPTSTISSQSNVNVPPPPNEPSHPGQPVSTDPRWQRAVSPDPRNARSTSPAAAFMHPPNRGTSPLPFEQIHSHYGQAFPTERRAGTASPTHPALQAQSGRSTTPLGIALDAHGQVAQDTMAGRYGAGPGPAQMGPGGVAAGAPPPPSNEPTGASRLARPPTGQYSESGEPILFYVKALYDYQASLPEEFSFTAGDIIAVTHTEPDGWWQGELLDETRRMPGANTFPSNFVVLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSP0</accession>
    <name>A8PSP0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732516.1">
        <property type="nucleotide sequence ID" value="XM_001732464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSP0"/>
    <dbReference type="STRING" id="425265.A8PSP0"/>
    <dbReference type="GeneID" id="5856822"/>
    <dbReference type="KEGG" id="mgl:MGL_0291"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0291"/>
    <dbReference type="InParanoid" id="A8PSP0"/>
    <dbReference type="OMA" id="INISAPW"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="715" mass="76263" checksum="60243EC103E0E114" modified="2008-01-15" version="1">MDGSPLGKISSPRDRPIGIYTSPLLPGAFHRVLLSLPSETPGSADQVTVKICTLCESAHLQPTPSLASVDLPTVISPINISAPWDSIQGSISPLPTPQPPITVTSIHEVSPTRDAVGPSSVRHDSLPFTLPSPLLPSITSQRGPPHSLSPRRLRPVDGFMASTTSLNTRESTSYGSITSSSQSSKNLHSYDMSTMKRSIEKWDPIVDLPVMSLPPDVPDVVPSPMSLTARSSDTFPLLSHSSRSLSSSVRSIPTPSLHVRGSGGGGGGHGSCSSGSGGGSGFGVTGTSGTTIGSSFRDSHASSTSLVPSLRVNLGPTTASSSVLTNSSNAPLSSSTSSSSLGGNVSAFAHSLFSYLPSPAVMTSHSSQTTHTAESPNLPALWQRVCIRTLPVFSSGTSGFSVEALGDSVETYVRLVHERDAKHARAILHDHFEKLVSTGLHGMAVQLQQNDGLHLLSEFLRTWKHYYGTVIPFLHASFLPLESKLWSLDLLYATSLHRSDASNMPHMSNASDRSVDTSALKASSTQILRRRESDALDSPSPALQASPSGLIRSSVSGSSVHSHSLQTHRSYPRPSPVPVLSSDVPERMNIRRILLIMFRDHIVLPICDWLYMASSQMEYTNNLDHPASSPIMGLRPQLMHLVNIMNSLGTDDASQDRIERLRRGILTHGAFSPRVSFLDPAQRPSLSAQLSPISPVPSHSMCNSTSTSPSLNTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSU0</accession>
    <name>A8PSU0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732541.1">
        <property type="nucleotide sequence ID" value="XM_001732489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSU0"/>
    <dbReference type="GeneID" id="5856847"/>
    <dbReference type="KEGG" id="mgl:MGL_0316"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0316"/>
    <dbReference type="InParanoid" id="A8PSU0"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="84" mass="9608" checksum="BA9A6F6295E6F283" modified="2008-01-15" version="1">MDWIHDASFFPMHMRTTMDKHGHMSMVAVPIGAQGLTEDDLLLEEIDSGDGDMEDEDSNNEDYYGNEYPDQDEWDAQSDSSIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSV1</accession>
    <name>A8PSV1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase</fullName>
            <ecNumber evidence="9">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0321</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732546.1">
        <property type="nucleotide sequence ID" value="XM_001732494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSV1"/>
    <dbReference type="FunCoup" id="A8PSV1">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSV1"/>
    <dbReference type="GeneID" id="5856852"/>
    <dbReference type="KEGG" id="mgl:MGL_0321"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0321"/>
    <dbReference type="InParanoid" id="A8PSV1"/>
    <dbReference type="OMA" id="QMLQWIA"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="151"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="299"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="875"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1124" mass="128596" checksum="E2CB3B0012D670EC" modified="2008-01-15" version="1">MSNQHALRPPESGWRSHDTEVALATPGLHPPEESREQPVKMSAVPNETATTAPGSVVSASTVHQQYPRWFRPQRQDSSFSDTNTPISPHPIRSQLAHLWRGKQESPRVSPPENEERPANIVAELQLGLFSAALLKMKIERDEQDIPRIPVLLQYLQVLVTDSVHMPSSGHVVYRIELRYGSGMLAWVIYREMRDFFSLHAYYRTQDVAATLSRRLTLDSESDRVVPSFPKGSFTSRLTRQWQHDSKERQETQDRAYRAALTEYLTKLIKFVMFRPEANRLCRFLELSAMGLQIASLSGHLGKQGYLQIKSKSSWRDTQAFMKLPHRHHPRWFIVRESYIVIVSDIQSLRVLDVFLMDQEFEVVRKHTLRSSSLKHAPDEKDEQIVGEHEQHSTGTVSDYVKRHRFDISNAERKLKLVARSEREMEQFLLSLKYAAHYNPFGKRNRFGSFAPIRRHVVAQWLVDGRDYYWNLSEAILHAHERIYIHDWWLSPELYLRRPGTPEWRLDNLLLKKAQEGVRIYVILYNEVSNQFTPTDSGYAKTRLMSLHPNIVVQRSPSHLKTGTFYWAHHEKLCVIDEMLAFMGGFDLCFGRYDTPSHALVDDAEIEGHSGADPNFLGPVRNGAEAHIWPGQDYANERVVEWQTLSKPEMDLIPRDKVPRMPWHDTGVQIMGQPARDLCRHFCQRWNMLLRTKKHTRRMDFLLPPSDLKPEDLDHYGLRGTCEVQICRSAGPWSLGTPKMIEHSIQTAYLKAIEQSDHFVYVENQFFVSSTIMDSTEIENSIGLALVERIVRAHRDKTPWRAIIVIPATPGFPMAYDHAESGSVRLISSLQYLSIARGPHSIFARLRSVGIDPHAYIGFFSLRAWGRMRHGQLTTEQVYLHDKVLIADDRLAIIGSANINERSQRGDRDSELACIVRDEDMIPSSMAGRPYKVGRFPHTLRVRLMREHVGLDVDQIEVGVLEHLSATSPVLQHTTSSEMVDETTVSATKATRIMSTVDPSTADLHGSTKPSFFPNSLLDPLACYDSVWKMVAAHNTSIFRDVFHCVPDDEIKTWAAYKTAIQHYEHVTSSGPGGLTSEEAAALIDRLTMCCGTLIEHPTEFLEREAAAGNYLFPMDHINPVIVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSY9</accession>
    <name>A8PSY9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732564.1">
        <property type="nucleotide sequence ID" value="XM_001732512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSY9"/>
    <dbReference type="FunCoup" id="A8PSY9">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSY9"/>
    <dbReference type="GeneID" id="5856870"/>
    <dbReference type="KEGG" id="mgl:MGL_0339"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0339"/>
    <dbReference type="InParanoid" id="A8PSY9"/>
    <dbReference type="OMA" id="VYEWQSE"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000938">
        <property type="entry name" value="Probable periodic tryptophan protein PWP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="383"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="7">
        <location>
            <begin position="752"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="880" mass="96923" checksum="2F23C88ADD9F6845" modified="2008-01-15" version="1">MKSSFRFANVCGTVYQQGNIQFTGNGDCLYSPVGNRLSVFDLVRNVSFTLPFETRKPIARVAISPANTSLVLVADEDGHALLINVHRRALLAHMNFKLPVRDAQFSPDGQYLGVTHGTQVQVWRTPSVLVREFAPFVLHRTYVGHFDDVLSITWSRTGRFFLTTSKDMSARLFSLDPVPGFRPKTFSGHRDAVIRAFFSLDEQTIYTVSRDGAVLVWQDKDEMGELESAEQAEGSSSDPEHAVGLTRWGVASRHYFYQTQTQVTCADFHAGTSRLVVGFSSGLFSLRDMPDFTEIHALSISQEKITSVAINSTGEWLAFGAQRLGQLLVWEWASESYILKQQGHFFDMNTVAYAQDGQIAVTGGDDGKVKVWNTLSGFCTVTFSDHSAPVSCVEFAKQGQVLFSASLDGTVRAYDLIRYRNFRTFTSPTPVQFVSLAVEPSGEVVCAGSSDAFDTYMWSVQTGKLLEILSGHEAPVTGLAFDPSGSGLLASTSWDRSVRLWEVFRRSQHTESMSLSSEGLALAFRPDGLQVCVASLDGQLNFFDAKSGAHMAVIDGRRDIAGGRRLDDKIQQRNNAAGSAFTSVCYSADGSCVLAGGNANYVCLYDVREHVLLKRWTLSLNLALDGTQDRLDSRQMTEAGNIALIHDLSDEDELTLEERTDRSLPGVQRGDLSKRSTRLQARTKCVRFSPTGRSWAAASTSGLLIYSLDELATFDPTDLDMDLTPQAVRAASLQGHALVALLGALRLNDPILEAEVYERTKPHEISLVAQQLPTVYLARVLALVASRMNPVSQSPHVEFHLSWLTALFQRHGEEIRAHSTTVYAPVLRAVQMALNELRSNVKTTADRNMATILYIWNVFSSRATSMESAGTNGISTNTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTA5</accession>
    <name>A8PTA5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0393</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732618.1">
        <property type="nucleotide sequence ID" value="XM_001732566.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PTA5">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTA5"/>
    <dbReference type="GeneID" id="5856924"/>
    <dbReference type="KEGG" id="mgl:MGL_0393"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0393"/>
    <dbReference type="InParanoid" id="A8PTA5"/>
    <dbReference type="OMA" id="CFETGMR"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="575"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="998"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1080"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1186"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="312"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="638"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="954"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1277"/>
            <end position="1510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP45404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1517" mass="168952" checksum="0032E952F5391937" modified="2008-01-15" version="1">MSPTRDFDLTPCFQALVLWFAPALAFIIMSVHALRKWSRCEVQVRSENSMHILHEKDGIMSAVTLLGFLEFVVLIGMRGNLGPAEASLTGGVQILASGAMFLSYILAFMLQHTMHMKARHGSDETLLLWTLHLLAGPVRVRTIIQITPTSTLIHMMLVVPLCMRLLFVLAALFLECADVEMGDNIALPEDADEDVEAEAEHEPELTPELAAEREMINELQPKESPMETAHLFSRLFFHWMQPLMSLGSRKFLKESDMWALPAGEDTEQLGNAFQYHWIKFSHEAQDAGLDLESTGKTRFWRTLFASYGRPFVIAAGFKVVQDILAFVQPQLLRMLLAFVQNWEWAPTEALRGTPLRGFVIAALLFLTAAIQTLSLHQYFQLVSIAGMRARAGVVTALFRKSLRLSNKSRGERSTGDVVNLMSVDANRLPDFLMYAHILWSAVFQITIAFVSLFNLLGWSAFIGVAIMMISVPVNTMLATYLRRLSAVQMKVRDRRTGLMNEIILNIKSIKLFAWEEAFTKRLLGVRNDEELPLLRNIGVASAGFNFFWQAIPFFVSLGTFIAYSMVNTQPLTADIVFPALSLYQLLNFPLSMLAGIVSMFLQTQVSAGRMASFFDSEELDENARRMLKAPASVGSDAVRFRKASFAWSNEQESPTLCDLDLTVHGGELLAVLGRVGDGKSSLLSAILGDMVRLQGRISVHGQLAYFVQGGWCMGATVRDNILFGRAYDEALYRQCLSACALEPDLEMLQLGDQTEIGERGVSLSGGQRARVALARACYAMADIYLLDDPLAAVDANVGAHIWEHVIGPRGMLRHKTRILTLNAVSYLPQCDKIVTLREGSLLEERGTFDEVMAMRGDVYRVISSLKKKETSVEKADTESPIESDQHETLPAWKRSLEPTDHCHRPRQLNKDELKVSTLRHLRESQAPQELQETGSVKWSVYREYAQSASTVGVVLFCVAHVLTQACTIARDVVLKQWSGENARPNVDTSRAARYYLTLYGLMGISTSVGVCVAPMILYVWLVLSSARRFHDSLFLNILRYPLQWFETTPTGRLLNLFSRDISVIDEVLPRVIQGLARSSVIVLGVICVVAYSVPVFLLAVVPLGLAYRGVMRYYLASSRELKRIDAVSKSPIFTWFQEALGGLSTIRAFGQADAFTDSFEARVDRNQMCYFPAVTCNRWLAVRIEFLGSTVILFTSMMAILMVTTGGRMSAGLLGLMLSQVLGTTQTLNWAVRSASEVEQNIVSVERVLSYSQLPMERAYHVEETAPTSKWPSQGVVEFRNYTTRYREGLEPVLRGVSFKTRPSERIGVVGRTGAGKSTLTLALFRILEATGGSVLIDGIDIATLGLHELRQSMAIIPQDAQLWQGTLRQNLDPLHQYSDEDLYRVLEQARLQSIVDGHSAGLLQPVSEGGSNFSSGQRQLMCIARALVRRSSILVLDEATSNIDLDTDALIQKIVRSEFSGTTITIAHRLNTIMDSDRVIVMREGKVAEFDAPSTLLKNKDGLFYSMAREAGLVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTV9</accession>
    <name>A8PTV9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732711.1">
        <property type="nucleotide sequence ID" value="XM_001732659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTV9"/>
    <dbReference type="STRING" id="425265.A8PTV9"/>
    <dbReference type="GeneID" id="5857017"/>
    <dbReference type="KEGG" id="mgl:MGL_0486"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0486"/>
    <dbReference type="InParanoid" id="A8PTV9"/>
    <dbReference type="OMA" id="IHDMYLD"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="191"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="541"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="91152" checksum="AA14F20369D0E89E" modified="2008-01-15" version="1">MAAVQSKLETVPRRTRALVALVVLALAMGHKQIVGLTKKRVHLLKLHRHRKRLHDVSLDQGLEQLYYPTDRRDGTINLIVPHRGQLRKASVTPTDPKTFQQDYSHFSLPPPVNKEAVRKRLDLLGVFGGLSPSSARKIRDHEAKIAPEAGESVSSASAMRVGVDREFLRQLRALFRIIFPTLRSKEIYMFVLHTFFLVLRTYLSLLVARLDGYIVKSLISMDKWGFLRGLGMWFALSVPSTYTNAMIRFLQSKLSIAFRTRLTRYVHDLYLNNHQNFYRVTNLDNRLESVSQYITHDLAQFCDVLSDLYSNVSKPLLDMIIFMWQMSRNLGVTGVAGTMIGYVLSSYVLRSVSPSFGKLAALEAKLEGNFYNAQSRLIINAEEIAFYNGASTEEGILRRSFDELVRHIRSILRARVGYNSMEDFVLKYSWSACGYIMMAIPAFSAQATSGKTADADPLIAKQTEGYISNRRILLAIADAGSRLMYSYKGVATLAGQTSRVYSLISSLHLLQHDDYQSVPRPSDLPPDAPFYDLGHLKGRHVENGDLIKFVHAPVVTPAPGQERGGELLVKSLDMQINPGDHMLITGPNGVGKTAVARILAGLWPLFDGTLEKPNNEYIMFLPQRPYLNTESLREQVIYPFSYQEHVESGRTDEDLMDILRHVHLAYLPEREGGWTTRKEWKDVLSGGEKQRMGMARLFYHRPKFAVLDECTSAVSTDVEGLMYAHAKDLGITLITISHRPSLFKYHQLLLDFKGDHKYEVLNLAGDVRQLTIEQELKELEAKVAQVGKWKHRLEEIHKELSFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU28</accession>
    <name>A8PU28_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732748.1">
        <property type="nucleotide sequence ID" value="XM_001732696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU28"/>
    <dbReference type="FunCoup" id="A8PU28">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PU28"/>
    <dbReference type="GeneID" id="5857054"/>
    <dbReference type="KEGG" id="mgl:MGL_0523"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0523"/>
    <dbReference type="InParanoid" id="A8PU28"/>
    <dbReference type="OMA" id="FHHEYEK"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="6">
        <location>
            <begin position="90"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="261"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="353"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="410" mass="45606" checksum="0D21635ECF48FC9F" modified="2008-01-15" version="1">MASARLREVTAYDGDMDLYGSHPLARTSSFVSPSLSPASTPTGLFSPHEQVDSPVHTAYSTSPVKPESQRLLLNARVSTRVVSKVPYKVLDAPELADDFYLNLVDWSNQDVLAVGLNKCVYLWSARNSNVTKLCDLQGMQDSITGLSWTERGQYLAVGTHSGLVQIWDAEREKLLRTMMGHSARVGAIAWNHHILTTGSRDRYIYHRDVRVPEHHVKSLQAHRQEVCGLKWNPTGDQLASGGNDNKLLVWDGLSETPLHRFNEHTAAVKAIAWSPHQQGLLASGGGTADMKIRFWNTQTGTHLSMMDTGSQVCNLAWNKTSNELISTHGYSSTNLHNQIQLWRYPSLSHVATLTGHTMRVLYLAMSPSGKSIVTGAGDETLRFWDLNTPARDQVERHDDRGLQSSFVKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUA7</accession>
    <name>A8PUA7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732049.1">
        <property type="nucleotide sequence ID" value="XM_001731997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUA7"/>
    <dbReference type="FunCoup" id="A8PUA7">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUA7"/>
    <dbReference type="GeneID" id="5856373"/>
    <dbReference type="KEGG" id="mgl:MGL_0642"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0642"/>
    <dbReference type="InParanoid" id="A8PUA7"/>
    <dbReference type="OMA" id="TVPHADF"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF13">
        <property type="entry name" value="MITOCHONDRIAL 2-METHYLISOCITRATE LYASE ICL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="484"/>
            <end position="488"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="598" mass="66427" checksum="CF3762166703C394" modified="2008-01-15" version="1">MLVPLTRVVRRIPARDLRSTCLQQGRMFSGSSRIARKRTETSTSTATSLVPPPAPLQLQPPTPEEEAHMFENSVHSVSNWLASPRFSQIHRPYTARDIVSKRGSMPVQPPASSLTADKLYALLEQHANQRTAISTMGAIDPVQQSQMARYQEVVYVSGWACSSVLTTCNNEVGPDLADYPYTTVPNQVQRLFKAQLHHDRKHWDERCHMSADERANTPWIDYLRPIIADADTGHGGLSSVFRLARLFAEQGAAAIHLEDQLHGGKKCGHQAGKVLVSTGEHVNRLITTRFAWDILGSSNLLIARTDSESAKLISTNIDVRDHEFIKGAYNLPAGTKSLSETLAEKEAEGVHGAELDKVERDWMDGVTLVTFNEAVANHNASNPSRLEEYDRRVDGGVSIGEARRIAQEIFGDEGVPAWDWDAPRTKEGYFHFKGGISAAIKRMKQFAPYAELLWLETKTPDLVHAQGFAAKIHQDFPGKWLVYNLSPSFNWSAHGFSDNDLRNFISDLAHAGFVLQLISLAGIHSTAVSTYELSRAFEKDGMLAYVDLVQRKERELGSDMLTHQRWSGAQYMDRVLQTVSSGTCSTSSMGEGSTEHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUE1</accession>
    <name>A8PUE1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ROT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein rot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732073.1">
        <property type="nucleotide sequence ID" value="XM_001732021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUE1"/>
    <dbReference type="STRING" id="425265.A8PUE1"/>
    <dbReference type="GeneID" id="5856379"/>
    <dbReference type="KEGG" id="mgl:MGL_0666"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0666"/>
    <dbReference type="InParanoid" id="A8PUE1"/>
    <dbReference type="OMA" id="GYWEFAK"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002724985" description="Protein ROT1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="209" mass="23358" checksum="846CE44E19F27B0C" modified="2008-01-15" version="1">MKLHIVVSVLLISLVGSSLAQMAQGLRKLDLEGTWSSGSGSVLTGQGSGESDTFFNPMRRKFTVPKTSGYSYSFTRDGFFEMAQFTYNSSGREPECFTASLKWQHGTYTLEGSNIHMKPYEGDGAIQVMGKCEDPQVKMDYYSENEIGANITVYTDTDIVFYSELDSMKVLQMHAFDGRPLPKMYLLYRPPRMMPTQSIFKKVIGAPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUF4</accession>
    <name>A8PUF4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732081.1">
        <property type="nucleotide sequence ID" value="XM_001732029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUF4"/>
    <dbReference type="STRING" id="425265.A8PUF4"/>
    <dbReference type="GeneID" id="5856387"/>
    <dbReference type="KEGG" id="mgl:MGL_0674"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0674"/>
    <dbReference type="InParanoid" id="A8PUF4"/>
    <dbReference type="OMA" id="NDRSAMK"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="6">
        <location>
            <begin position="48"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 4 C-terminal" evidence="7">
        <location>
            <begin position="383"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="621" mass="67892" checksum="DF871B9789AC33F2" modified="2008-01-15" version="1">MVDRIASWPKDDDAFQSHLQEQRHAILSILSNALPPAADTEPYMGQECVGLGDAWRALYALVRSSVHEHEGNSCIVVGESGCGKSLLVESVLRRIKAECHDKEQMGQHASPWTVSLSALVHPTDRQCLSDMARQLMDQGAMGLDDVDDILGREQQDMDSDTESDDRPLAEWASASLPPTMHRARSPTQTGMGLEAHLALDPEFESEHLVDADVEEAGMAEEDDDEEGEGEEELVASDNVVSVREHAAHAQPNASASVPDSFAQSILSTLSATLSHILSLLTRTSSTGETSHKRPLVIVLDQFEQFAQRPRQALLYCLLDAVQAASYAPGLLIIGLSTRVDAPDFLEKRVKSRFSHRSVHVHPPSFEQYIILTRTALLAGASPSTPFGKTWCHEVDALLQDSAFRACIQHLHALSGDVRFLYQALTPPVAALSVASPCLEAGAFVHAAELQRHDPTLAFMLELSMPEMVLMITARHLQLSEHEPFTFEMCFHHICQFVKRAQRDLGTAIDATERRIVNVSMAGLDALASREPMQQAFQRLLDAELLLPEPARVTLALPSGIASRTGTVTSPYGTLPGPTVIPTFLRVRSQVSAKAILESVCSPERVEPLSSLIVKWAESTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUI0</accession>
    <name>A8PUI0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0691</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732098.1">
        <property type="nucleotide sequence ID" value="XM_001732046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUI0"/>
    <dbReference type="FunCoup" id="A8PUI0">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUI0"/>
    <dbReference type="GeneID" id="5856404"/>
    <dbReference type="KEGG" id="mgl:MGL_0691"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0691"/>
    <dbReference type="InParanoid" id="A8PUI0"/>
    <dbReference type="OMA" id="PVRMYCL"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="312" mass="34621" checksum="B6CEAF0B1BA070D1" modified="2008-01-15" version="1">MTTIRQVHPSPNVAKGVEYWEGVPATVDGVLGGYGNGTLPRVDALGSRTFLLRTLPYLSSTPPPALNESPQMWTHERIRQRGGKGKTVTRALDCGAGVGRVTEHVLLPLVDEVHMVEPVLKFLQEAKRRSASWKPLQLSVEQSPFCARKAVYFHTSTLQEFRVADPMSSQDTPHQRSTAPPPSYMQGKVTEPPVKPVLYDIVLCQWCLQHLSEADLILFLKDAKTTLRPPSSGGDATFTCDGGVIFVKENVCRDADDGGEASWYDSEDYSVTRSRTLYERIFREAGLSVVRSEVQLGFPPELFDVQMCVTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUL1</accession>
    <name>A8PUL1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732117.1">
        <property type="nucleotide sequence ID" value="XM_001732065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUL1"/>
    <dbReference type="GeneID" id="5856423"/>
    <dbReference type="KEGG" id="mgl:MGL_0710"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0710"/>
    <dbReference type="InParanoid" id="A8PUL1"/>
    <dbReference type="OMA" id="ATHARNN"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727955" evidence="2">
        <location>
            <begin position="21"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="818" mass="82895" checksum="D0252EE5D65F6540" modified="2008-01-15" version="1">MQYFMLPAALMTASGMLANAAPVSSGASANQKGAQGLEPMAPSATRPGEPLVVSWGPASGNSDWKHMNVSLVALSENGKNKVTHLATDVDGTDAKNNTLRTKAPKHLGNSDSTNYVIRFTDGKEHKDSPKFTIEHKNHTYSKLSARHGDSHSSASSSASDADSNGASSIDSSDISAIIQQMLSSGHAAGGRSAAAAKAGGDDVEQSGADGLEDEEEQEDDGATKVMSSSSSSSSSSKGQLPTPVTIDGVMYVPMVGSSLPSNLPTSGLGLAKSNSTTGDGSSSSKSRHHAKQTHKPDSRDAWSDIAQSMDAAEAKHRHHGKSSSSSSGETDSDMMGVRNAAVSMPSTSKNHRHNGKSSSTTSPSSSSKSHHHKHSNSRGSGSAHGRNAAASTSGSPSSSSSSKKHKGHHGGQQKLHSSTTGASSSHDSKSSSAPGSSSASSQSSSTNGSSSSGSSSSSSSASPSGGAPAGKNAAASGGSSQGGGSDSPSGGNGGGGPTGGEMTVATPPYAAQCQPLKITWKGGEPPFRPKITADGDVSNVLSLLDETSDTGLTWKVNVAEGQKFTISVCDATGQCQASAPVGPVGKGPGDCLNGDGAQKRSFAKRGGTTGSWDDETSSSSSSSGRNHNTRTKSSSSSSSPSASSSSTSAINLNRLTSLTSVPSAAASSILSSLPSVSFFRGMDPLAGLGSLFSRESGSLSSTSSSPMASRSMTRSRAAPTSTSSRRRHHGTQSASQGSSEALDGQMTRSLHDEQSNGRDQDLMDVLAQGIMGDSGLSPSQISEYFHSSGHSTSDHQRHGQMSMTVDYHRGTQSVSMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUV7</accession>
    <name>A8PUV7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732189.1">
        <property type="nucleotide sequence ID" value="XM_001732137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUV7"/>
    <dbReference type="FunCoup" id="A8PUV7">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUV7"/>
    <dbReference type="GeneID" id="5856495"/>
    <dbReference type="KEGG" id="mgl:MGL_0782"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0782"/>
    <dbReference type="InParanoid" id="A8PUV7"/>
    <dbReference type="OMA" id="WNADGRH"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="382" mass="41368" checksum="01A4D8B05DC677F0" modified="2008-01-15" version="1">MTAASGREAYRGIGQLEDPPTDASFFTRRHLNYPPFTSARPPKELRGGHNTGVRALAWNATGDVLMSCGSDHVVRAWNPERSSDVRATTEFTGHSGQISAIACHPTDPHLFATGGIDRTVRVWDLRAPSSTKVISTPGSNINLAYHPQGRFLAVGDKSETVSLIDADQGCFLHKIKDGSIDREEINELAWSPDGSMLLLPMGSGTISFLRAPDTPELEADASTAANGLKQCWEQVMIHHAHPAAIFCVKWDPTERVVATAAADSTLALWDSALWDCSRVFSDFKFPLRTIDFSFDGEWLAVGGEDPDVALDILTRHLQISLAGERIVHRIPVSTTINSLAWHPSKPMLAYSGTDTSTSLGPGIAATTGRAATTPVIWVYSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVH7</accession>
    <name>A8PVH7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731602.1">
        <property type="nucleotide sequence ID" value="XM_001731550.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVH7"/>
    <dbReference type="GeneID" id="5855908"/>
    <dbReference type="KEGG" id="mgl:MGL_0870"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0870"/>
    <dbReference type="InParanoid" id="A8PVH7"/>
    <dbReference type="OMA" id="PLMLEFM"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="681"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="899"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1293" mass="143353" checksum="305BCAEC579A330D" modified="2008-01-15" version="1">MALDAEALPTLAQQWASLGAAHAPAEDVPEDSPRIASALNTFASYVDESKKIYLSAQASGRRINVFFGRSHLMQSLSFDDVPGGKAAVLKGVSSVALGTEAPGSDNLMLVASFGGIIAIWRLDALNMAKMGQAPIYSRWRLDGTLPLRGQLVSSVSVWKGNLAIGSNKCVSIWKRGTYASAPWRNIWSARTPRPLLRVQWSADGQFLAAVPLCDTRVLVWRVHDKQVHLISKLRHTRHVHSLHWRRAREDLENVPVLVVITSNSVAHVYTKMPEESPAFYLWASIDAASSLEGVVPASDTSAMRHVVSLMYCDAYYISVALHHDIQLLEQQEQLHITGIGNTSSAESQRRSARIKQLKQYMEQGPDVFFALLADGSLALFVLLNIEKNTPSLSQTLFTLKVPPCISAELSHAPLMLEFMPLAPSTSRVSDIYPTALIHGHTASGLRGTMAVSLLLLLDGDVHGLFVQNTTTDASMPAHSPSHAHAFLRAEHRSDILSLQTTNDHHSLLSFSRDGVMIWWNLCEHGEAVSMNSEYQVRLRNAYAVCAMGQGPNLIALDESHLVLALFDKSSFASSSSHVTTVNNISMMFSKLQGVTPDTLVALYSFEAQDAHNVVLVRQDGSLLTWTCASTSSGWVLHPMQTHRLNTDDVVCAELVSHWHPIECKPVLITLSSSGTLHVWEALTWTCLHTIETQQNAVGLCADILGHIAVLSHTNRTWKVSIHDVRLLPFASTLVHEHNMSNVAHTPSLAWTTTCDSGAMLAVSGDQRVTLFVEAQFVWAPIARVDLQGMGSANISHVGWVAPHRLLVTSTCQLFLFESEVKADGCNVTAQDLWTHRSHMRPYHDALFLLRCMQFGLTKDACASIQLIDAASRNGRWNHLSWSFEREPLTALRISNPIPAMLERIQANGLVDIDSHSVPALLAVLQAAHQIVRTDVDVHAKQYLLSWYASQHTSAPIIWAYLSETQDALLSKVTSEWADRISWPMVRDSGVFGWMRSREALLPIMEQVARAAFTAGDDIDPIRCSLFYLALKKPQMLKSVWRRAVGHPDQSKMIAFLGHDFSEERWRVAAQKNAYALMSQRRFEFAVAFFLLGNALSDAVHVCVRQLNDVALAIALARVFENEDQGPVFKRVLRQYAVPHAHETGDRWFGMWAHLVLGEYAEAVHMITKPLSSSVSGPLFDLPDPSLLMVLEYFKRHYWCYAALSPQDETRCVAFYAQLLSRTGCDLVGLAMLRSWSFARPAKPPSHVEARNPDPESTDSDRPEVSKKIGSLMGERRPPPAQSMAEFDMSAFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVL0</accession>
    <name>A8PVL0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731630.1">
        <property type="nucleotide sequence ID" value="XM_001731578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVL0"/>
    <dbReference type="GeneID" id="5855936"/>
    <dbReference type="KEGG" id="mgl:MGL_0898"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0898"/>
    <dbReference type="InParanoid" id="A8PVL0"/>
    <dbReference type="OMA" id="NACGAKW"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052138">
        <property type="entry name" value="GATA_ZnFinger_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47255">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47255:SF4">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="801"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="858"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="926"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1028" mass="108344" checksum="2C55FA3842AE343A" modified="2008-01-15" version="1">MQASLPAGAPGSTDVGPDAPSAANTISTSEGNPAGDAPASNRVSAPTPAPPSASEQAPCNNKASEKALASDARALSTPSDGLGRGPDPVPSTTVSPPPATTQAAARAPKRVSKPSSSAARAKQTTLADLKGGNIGTLTQDPPAPGFLPAGGGGRKVIPELVLPFTLPTRPLPSTVHGAHSESAGAVALPDSDTPEPLEKSMVFLQSLRQTRMMHMLQVLPPFSHRHRAGTDYYHSVPPELLPGLEDGSSHTLISLGRADVHVGPVVYYGVRFWQARPVPKTAMAKVSDPLHQPFQHHAAQHGTALTVSSSPATVTQHNQLPPPPSPNSHSTPTSGVFGSTPTASTSSSERTTAAEAQIAPLAPSQTPSPHRVPTPLDPGFVARLQQRAEKDSHLQQLLQLARAGQLAPNGLAQLNAILGSLMVPAPSATTTSPSRPAPSVAPEASTPSTHAIPTTSPASAVRAAPRRSSPAPCHNDEHAPPPIVLVEFPENPSLHFVLPLWHMAIERRTTHQGARRILLSFLIPAIGSKAAGESGKNEASEAVHGMLVQDLDFKKSHQATRSDQTATQTDEMSSTPACTSASSDSMQKSEASEQPVTNPSIPKAAPSGSNARRARRSSSRARNDRNIHDALPDPSTRVSRPRPVPTRNHELYPVTWNITSQAPLDQRLWECLGRVPGCLTDGHWTSSYDERVWNLLKGSLRSRMASRPPEYTLPTHLLQEDIPVGLVDHVSDRYMMRMLVNTSRPQPKRKVAMLSETKDTPRANTASIAMRAPIVSEDGSIPVKPKRKRHVATHNPDGSIKSCGACGKTKTPMWRRGPKGPSQLCNACGAKWKAGRLVVPDVPPPPILNDVMPIRHVKQTPPSVPTPASSYVPLDRSKLDPLPTPPSSIPTPSIDLPAKTEATSSCTIPSATPNPPPNATSATSSVSMPTATSIQNTDATSPTSTTPPRPSMPPSIFTNRKPLASTDLPSTTLLSPPTDALRTSDAVRLPLHAASHATVQTESPSHLSPQSLNVRPPPSPDNGAEATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVU1</accession>
    <name>A8PVU1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731687.1">
        <property type="nucleotide sequence ID" value="XM_001731635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVU1"/>
    <dbReference type="FunCoup" id="A8PVU1">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVU1"/>
    <dbReference type="GeneID" id="5855992"/>
    <dbReference type="KEGG" id="mgl:MGL_0955"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0955"/>
    <dbReference type="InParanoid" id="A8PVU1"/>
    <dbReference type="OMA" id="YVLESVN"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="286" mass="33044" checksum="6ABD81542A55C586" modified="2008-01-15" version="1">MRLRRLPQRTCRLLRVSLYAWCVCMLVQWLLAGSYVQGSAWRDASADRAWPRHVLVLTAHPDDECMFFGPTIQSLLKLNVTISALCLSRGNAEGLGAIREQELTASYGVLGVPRERVTCINDHALQDGMQEEWNPRHIQDVIETHLRITLPGQLLSNNHHNMTRTDVEAILTFDEGGVSLHPNHRATYEGARMYVEDMRARKQGDHKPPALWSLYSLTWRTKFLGPFSGVAQRWSRSDYVFLAPLRMYVTSLAAMRRHRTQLVWFRYLYVIFSSYMQANRIYSTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWA6</accession>
    <name>A8PWA6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731790.1">
        <property type="nucleotide sequence ID" value="XM_001731738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWA6"/>
    <dbReference type="STRING" id="425265.A8PWA6"/>
    <dbReference type="GeneID" id="5856095"/>
    <dbReference type="KEGG" id="mgl:MGL_1058"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1058"/>
    <dbReference type="InParanoid" id="A8PWA6"/>
    <dbReference type="OMA" id="CCTSQLS"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="211"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="298"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="558"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="598"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="682" mass="74929" checksum="E88CFBD673992808" modified="2008-01-15" version="1">MCCFSQLSLLSSELAMAIRIDPFTLFPREVSLRVLGFLDAISLGRAARVSRLWRSLADNDLLWRNMCEQHIERKCEKCGWGLPRLVDSRAHGQDHSMSLSRNLTPGDEELRQAASAVSDGSLRRSVTAAANAAALERRRTHTSNEDTPNIPSHLQSLEESPQRKRVRTDGQGAGAGVSGRNGSIRPWKAVYCERFAIERNWRYGRYCVRVLRGHTEGIMCLAFREKISQLSHPILITGGYDRTVRVWNLQTGETLRVLTGHARGVRCLQFDDCKLITGSMDRTLKIWNWRTGELLRTLEGHTEGIVSLTFKDLILASGSADSSIRVWNCQTGECFPLNGHRDWVNALQLWSGSSSSNSSDSMFLFSASDDFTIRLWDLRHRECLMVFQGHVGQVQSLKLVMMDQSTVRKLARGSMKVSGETEGDAADEEGLSMSMASSTSSPDNGLLSNTLTGRNARMPGSGSARRIPARLLRMHERLCAANLVPPLPPYATLQDVEDGIFDGVPDEADPMSSPSMPTSTSADKTCGSKSKRPVLVSGSLDNTLKFWDVRTGRCFHTLFGHVEGVWCVDADTLRIVSASHDRTVKIWDRDTAQCQITLVGHRRAVTTVTLGDDKILSGSDDGDVRVWSFCPPDDGASMTSSCGTPANPVSAPSATSSTTTSSAPHPPYANTVMTTTPTPVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWD0</accession>
    <name>A8PWD0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_1071</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731803.1">
        <property type="nucleotide sequence ID" value="XM_001731751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWD0"/>
    <dbReference type="FunCoup" id="A8PWD0">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWD0"/>
    <dbReference type="GeneID" id="5856108"/>
    <dbReference type="KEGG" id="mgl:MGL_1071"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1071"/>
    <dbReference type="InParanoid" id="A8PWD0"/>
    <dbReference type="OMA" id="IHLDLRC"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725368" description="Mannosyl-oligosaccharide glucosidase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="15">
        <location>
            <begin position="25"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="14">
        <location>
            <begin position="270"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP44589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="762" mass="86413" checksum="941D09329F722931" modified="2008-01-15" version="1">MWAQLSLWLLALTACAFAHNNVSSLWGTYRPQLLFGMRPHVLETLVTGLVYFSPESLQRGIPVRHSASENQGMDAIKWVYHDGRNFGIQHLVDRENNYMIETSFVKTGHTEGQPGHWAARVRGTVLDPSKPAHLLTYYYVGSESARHSLQVDEHGMVHGPNLGGFSMRTESASYNHPIDGDSEMMFAGLSIDPAETWRGADVILGEHVHQHQEMMRQKAAQPSAYLRLLNTTEAPATFYAMQKTFQGNFSYDVFFDSHVSPAHAKLPDSEHLTLALDAHISTYEQEFEQRFHLASTFSPKQVAYAREITSQLIGGIGYYYGECLVDRRPTNDSGLVLHDMHGAKPHPEGPYGLLTGTPSRSSFPRGFYWDEGFHLLHISAWDPKLAQEIFESWTRLIDADGWVAREQILGNEARSQVPPEFRTQYPLHANPPTLIFGLNTLLAEYEAELAKVHEDVTDVNSFAGVDGSAQSDMERAKQMREHLLALYEPWQRHYRWFRRTQRGQIKQWGREASARNEGYRWRGRSATHVLTSGLDDYPRTATPHVGELHLDLHSWMGLFAKSMARFAAALGLEDDAFEYETHVERITANVVDLHWSSTHHMFCDASVDETDESYHECHAGYVSLFPLLTRLLPSDSSELGDVLQMLRDPAGLWSPHGIRSLSAQHPLFGKDEDYWRGAVWVPINYMVLNALRAYAQEDGPYAAQAASLYAELRKNVIDTVLGEYERTGYTWEQFDSTTGHGRRNHPFTGWTSLVVLIMAETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWE2</accession>
    <name>A8PWE2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1078</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731810.1">
        <property type="nucleotide sequence ID" value="XM_001731758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWE2"/>
    <dbReference type="STRING" id="425265.A8PWE2"/>
    <dbReference type="GeneID" id="5856115"/>
    <dbReference type="KEGG" id="mgl:MGL_1078"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1078"/>
    <dbReference type="InParanoid" id="A8PWE2"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="298" mass="32957" checksum="48604878C20A6E7E" modified="2008-01-15" version="1">MLPVILQRMKMDDEYNDHTGEGPSSIHTSDVQCLPSQLSWDSCGPAHHAHYASLSRLSISERAGPSRSQGGRIRHAPNRSLPRGDCLLMKETAAEQQPSAPISIPEPHDEYHPRSLSRSFSSYSAASGTSEGFPYTPKMGTSEISIDEERGTGLETLPRKSPMQVSSLLLPEDHERSPNGPFSLAQFYGEPSSSAESRPPETEAAISIPNKNFVCKSKPSNSHAGKFECSYCQKRFSRPSSLRTHIHSHTGEKPYRCDVPGCGRCFSVHSNLRRHQKNHSLSSLTPIIHQDITPPQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWF2</accession>
    <name>A8PWF2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731816.1">
        <property type="nucleotide sequence ID" value="XM_001731764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWF2"/>
    <dbReference type="STRING" id="425265.A8PWF2"/>
    <dbReference type="GeneID" id="5856121"/>
    <dbReference type="KEGG" id="mgl:MGL_1084"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1084"/>
    <dbReference type="InParanoid" id="A8PWF2"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="671"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="966"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1206"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="968"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1094"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1227" mass="135041" checksum="5709C7AA10892E86" modified="2008-01-15" version="1">MIFDIGHESHDVNPSLPEFRVETGPDLFSTPQSSHMNESSHEGDSNRIGVKRSADTMDNSSNEIDNACESSSTSKVLKETTGGQKQKSTRGARACTNCHRLKMKCEVSENGGPCQRCARSGHECIFLESNRGRKSDKRRKSEATQQNLKKVEELFVSLLQNAYELSHSPLSCETTHPVSPYPISLGTTMNEAAGSPQSGSATTTAISPTTVDMLVTRVQSLLSMERVTNDPRSIHTVAEQAAKFMQQMGMLEDSMMVRVLDTSEEGLLKHVVRTAISGHTFAPHPPLSKPARSETVDSMQVPHLPDNTLNPLGLFAEASLQNWHRQQADNGRNASTSRPSSMADSTHPDGRGQEGSSTEPENSSQEARGMPRRSSQFGVANDAYFHPSSMSDLRTSENGTESPPELLTEGIISSEEALELFRIFFHHCSLHMFLLDPEWHTPTLVCSRSPFLFTCVCAVASKFYTRRPDLYVQCQRRAIKGAFDAMSHGFKSPDIVQGFLLLTLYNQPVERYEEDRTWLFAGVAIRMAQDLNLHRKCVMSAEARADEPTMRDVLNRERTWYICFCVDRTLSAQMGKPYSIREDFLIRHASEWCVQRFSRPWDLGICALVDLLRVQTRQLDFLYSSTVTPSGLNIDLDYPAILPSFNEQLTETMQYWYRLGLDSVRRTLQPPLTHESARPSSQTEPQPHFYSHSHAPSYTHARSHPHLHTMPLNALGSRNNPPGPPCTHSETPSRATASPVNLTCVAPSPHASHSHSALDSEPDVPHRGVPPNNKCGDGIHSLIPALDRVVTHLDHTGTADTLRASALLALHEAGPPADDADLATRSMYYIARQAPLRYNYAVLVLNSFGLQYALEHPSDGASADKPQYLVRCVHAAKEIIATVKCGMREILRYAPDPTFVAVAYACVFLLKLIRPVFSRYINEDEILALVNYTIEVLEEAAVDASHTPALYASFLRMLVESRLDQRSGEATYNSSPLDKSSDKGPRRTATSMDGVAQGIPESHEFYRMQGTTMAPPPSAEAGSAHDTTHGSRLNKSTMAPSTSTHVSMDQDPSLSSSRPPAMTVNPSQVNPMAAEIASRDQNQHPPSKSLSGSHHCDTNEHRLPTAISMPPLSTTPSPAEFHNKLHDAPGPTQDTLSDLHGWDALQYAKAQGVEVNRVLDDSFWTSLLPPGYGSGVVGSGLGSTTNAFDLNRDVDLFKPASHWGSSRAALTPGATRPSSPTLLHMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWI8</accession>
    <name>A8PWI8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731847.1">
        <property type="nucleotide sequence ID" value="XM_001731795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWI8"/>
    <dbReference type="GeneID" id="5856152"/>
    <dbReference type="KEGG" id="mgl:MGL_1115"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1115"/>
    <dbReference type="InParanoid" id="A8PWI8"/>
    <dbReference type="OrthoDB" id="3366890at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14704">
        <property type="entry name" value="bZIP_HY5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="422" mass="44977" checksum="B34C07F16A2BDE3E" modified="2008-01-15" version="1">MTASQTIDFDPTFAICAESESPASLSPSIVSTSPAPPTPSCSRKRPADSDASSLPHCKGRRSSEEEKLARRLARQQRNRKSAQVSREKKKAYVDQLEHDLAVLRAEKQETSQREKEAIEKCAKLELKVEELSGKLRQFESVFEVWIKPHLHATNAGSLVASACGAESQCMKKEGEDCEVNSSISDVVLATAAPAAALTMAGPSSPIDSNSSGRTCLPADHSVSSACAAANGSSVASEHTSDTDASILLEELSFDNLFPSTMPDVSLDAQHFDESMHPFTSISNTVPIFHSSTSTQDPAGQTEDGSSKVCERSSDDSIIGLPSSDLSLLISPFTPSSDSSWQSMDDEASFHASGVTPTDKANVTEPVAPILSSVCSSSNQQHQLSHLSPCGYLDVDLPVGSEASNISLHELFPSVNDQFLPCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWK2</accession>
    <name>A8PWK2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731861.1">
        <property type="nucleotide sequence ID" value="XM_001731809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWK2"/>
    <dbReference type="STRING" id="425265.A8PWK2"/>
    <dbReference type="GeneID" id="5856166"/>
    <dbReference type="KEGG" id="mgl:MGL_1129"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1129"/>
    <dbReference type="InParanoid" id="A8PWK2"/>
    <dbReference type="OMA" id="HTYTEAH"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="384"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="462" mass="50008" checksum="AF4797C6CC053E75" modified="2008-01-15" version="1">MRHCERAPPLHAPKPKIFYTMALEVPGDVICPSHAIAGYSCPNENKSYLLQLLTPAASSQHLLALLDDARILMFDKAHLATPLHTIQAGQQESMKALSNIESEKSAWIAASSAGYLAVWDARTNSTAPAMRLVGPSSAPYLSLASSSTYVAAGTELQGSDAYLDIWDLRQAGAPVRTYSEVHSDDITSLVYHPDESMHHGILLSGGMDGLVCATDTNISSEDDAVVSVGNTNASLARVGWAACPDSYTFTPRSSVVDVGMDEHEQALANSAHWNHLGPAYAISNMQTLSLWDADKFDCIKEDIEVRKPTSYRPPWVTDYVIDACAKGPFTRPGSILAPGVHLYVGDQEGGIALLSAEAQGQDQENDIVISWKMHARLPSAEKHSQAHADIVRCIEWDPIHARLFTGGEDGRLLAWSLDASEEPQPPSNASKTKLTDHSSQKSSGRPRPTGLDPAKKRYSPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWK8</accession>
    <name>A8PWK8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731867.1">
        <property type="nucleotide sequence ID" value="XM_001731815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWK8"/>
    <dbReference type="FunCoup" id="A8PWK8">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWK8"/>
    <dbReference type="GeneID" id="5856172"/>
    <dbReference type="KEGG" id="mgl:MGL_1135"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1135"/>
    <dbReference type="InParanoid" id="A8PWK8"/>
    <dbReference type="OMA" id="CIYARFM"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="412" mass="42863" checksum="7B8F6DDAB3A4013A" modified="2008-01-15" version="1">MFPSHDFNEIMPTIFRRFVEKEAHDWRQIYKALQLLEYIVKNGSERVVDEARAHLSTIKILRNFHYIDEQGKDQGVNIRARAKELAALLSDVDMIRMERRKARANRAKYQGAGSADFVPGSGGGRYGGFSSDAYYASGGASGAYGSAASAASAQPDFDEYDAGDDETHTAPSSVTQPAPAQTAASTQGSAQPAVADLFSFDDEPAPTPKTAALTSENDGLGSAAGSSSLADADDFDDFQSALPSQPSYASTKSPAGSTGSSTPAGPKNNGALFDLLDNAPLTSSSTKPVMPSVPAPSRSQTQARSPAPAPAPLSIPPPVSSLQPNPKPAVMKPTSTPTQKAPASSASLFDDLWAESRGSAGVTSKVGNNKSMAQLAKDQTSHSVWGSAPSGRGAPASTSTSSGASKDLFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWT3</accession>
    <name>A8PWT3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731941.1">
        <property type="nucleotide sequence ID" value="XM_001731889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWT3"/>
    <dbReference type="STRING" id="425265.A8PWT3"/>
    <dbReference type="GeneID" id="5856246"/>
    <dbReference type="KEGG" id="mgl:MGL_1209"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1209"/>
    <dbReference type="InParanoid" id="A8PWT3"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011999855" description="Nucleoside transporter" evidence="8">
        <location>
            <begin position="16"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41424" checksum="3C8D793202C9DB73" modified="2008-01-15" version="1">MLVASMILSWVLVLSVWIRGPHVPANPHFYYGFLLFLSVALAIAQTYLQNATMAFCTRLDINGSIIGYMLLGQALNGVIGSVLNLLSSMAAATHMDANEAASTQAIQNQQAAYTVFIATALLQLATWYAFEHMLHVSHVKQAVESWTMSDAFAAHAQMSIWDTVWRVQRRLVPWSVSIFGLFATTLCVYPGITSRVRTVTETRWLNNEGIFVALHIVCFNVGDLLGRRMPIMYPITNVRRAYVAQICTAARFLFLPFFLWCRLDIYKTSPIPDTIFFLGVVALGLTTGWLSTSFLISGPQSVAKHDESTSTQNNGLDTEARQDQVLLHDETMHEASAAEHAGTQDAAMASMLCSFWLVAGLTAGGCLSLLLNVFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWW3</accession>
    <name>A8PWW3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731971.1">
        <property type="nucleotide sequence ID" value="XM_001731919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWW3"/>
    <dbReference type="FunCoup" id="A8PWW3">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWW3"/>
    <dbReference type="GeneID" id="5856276"/>
    <dbReference type="KEGG" id="mgl:MGL_1239"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1239"/>
    <dbReference type="InParanoid" id="A8PWW3"/>
    <dbReference type="OMA" id="RMQMSAS"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="249"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="861" mass="90330" checksum="CFA3D27AE0C8F289" modified="2008-01-15" version="1">MTQNPVVPPARHSTNSSNVSRTNGPSSGRGAFHGAHGSASTTGRSSQGRSGNARHSSAGGGGGGSGSKHAPPSGRSSSASSQSASELMHERLRMLLDMLVGQMVVVRLRGGERYVGVLSAASTVSDEVALVLSLAQSISNKDGGIKLGEVMPSLVVPGAEILEVDVSGAKVSSGAELETAQRRGSGFRTDTEISAGSNARSDGRKLQRWDDGPDDGTVPGANGSSQTSSLEQSTDLGPWDQFAANEARFGIKSNYEETMYTTRLDRSGKDFKAREKEAERLAKEILEGSTSNPHVAEERNQIDPQEMDEEARYGAVIREQQQQQQQQQQKQETKQPPPQPPKSAEPKTGIASAKSAGASPSLASTPVAAHEAVSRPNKELTADFRQFVSAERERLVVRKAELAKKEKQSRLADLKVWAQTFQLKTPVPEDVANMRRYAAPTTKGMSNSTSTGGLNVPTGAVRNHSMSSTSSTSSSASFKPSLSSRDSYAGGWQGSSNASGAPLSSSQSKSDMEEVRSKLASMTIPAIPPFKKPEEKKPPSKLNVKASAFNPQAATFTPGAKVTPTQASATPAKLDVPDLPFFGKRELTNRPSTTSMRIMDEFRAPKTKKLGEASKASVWWSYTGRPYRQLMAASGVYANKPLMPPPFINDAASVAAAAAVAAANAAPMPPPMFPMAAAYAPGLSPAMQHIPTPATGPPHGSSPPTMPRPMNGKPPHSPHQQSIMLPPPPSGSPHTVGQQPYTMVYPIGQYRFPARPSYVPPADPHGTPLMYRPTPPMPTAPFAPPGTPGGMPTPAPHGMPPMGPYANMHSSSSRKRSGSASHRGGANGSAGSNNLGNGGGGKNAARKSRGDDTGGKAASDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX01</accession>
    <name>A8PX01_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1277</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732009.1">
        <property type="nucleotide sequence ID" value="XM_001731957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX01"/>
    <dbReference type="FunCoup" id="A8PX01">
        <property type="interactions" value="649"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX01"/>
    <dbReference type="GeneID" id="5856314"/>
    <dbReference type="KEGG" id="mgl:MGL_1277"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1277"/>
    <dbReference type="InParanoid" id="A8PX01"/>
    <dbReference type="OMA" id="HIKVWIS"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="153"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="294"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="76861" checksum="20A70252395B7358" modified="2008-01-15" version="1">MAAWIRYATWEATQGQMDRSRSVFERALDVDPHHVPLWLRYTEQELKMRNINHARNLFDRAVSILPRIDQLWYKYVHVEELLGNISGTREIFERWMAWEPDERAWNAFIAFEVRYHEFDRASAVWERAVTCHPEPKQWIKWAKYEEDRDDLDNARRVFHMALDFFGEEEAALERAQSIFTAFAKMETRQGEFDRARMIYKYALERIPRARSEGIYTSYTRFEKQFGSIKGVEDTVTQKRRLQYEEEIEAANGATTGNYDTWFDYARLEEESYRSLVEEGAPISALEVACNKVRDVYERGIRITPPTAEKRLWRRYIYLWLRYALFEELDSMDLERAKKVYASAISAIPHQKFTFAKLWLNYAKFEIRRLDLALARKILGTAVGLSPKPKLFKGYIEIEMALKEFDRVRKLYEKWIEWDPSSAATWVKFAELEQNLFDLERVRAIYELGISQADSELGGLDMPEVLWKAYIDFEFGEREMERVDALYERLLEKTSHVKVWISYALGKMAAVIALEEDEDAEAEEEGREAPLSDEQLAYRASSHQEAAKETRSIFERGYKRLKEEGVKEERVVLLEAWKAFEVEHGDSASVDSVQARMPRVIKRRREVPDGEGVMEEYYDLAFPDDEEQNKPAHKLLQMARAWHAQQSADSSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX23</accession>
    <name>A8PX23_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732031.1">
        <property type="nucleotide sequence ID" value="XM_001731979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX23"/>
    <dbReference type="STRING" id="425265.A8PX23"/>
    <dbReference type="GeneID" id="5856336"/>
    <dbReference type="KEGG" id="mgl:MGL_1299"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1299"/>
    <dbReference type="InParanoid" id="A8PX23"/>
    <dbReference type="OMA" id="CVTHGSP"/>
    <dbReference type="OrthoDB" id="3345147at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="178" mass="19810" checksum="8B5DD1F7EA4CD517" modified="2008-01-15" version="1">MSPKNDFFPFMIVILAFVGLTLIGVLAIVLYRTCLKHKLVKTSVHASKNSSSEKFGHMRPAEIRQPPKVYPVMSSVPRGTRARYSPQFDAPQYSFLDMNDDSLVTPGVSNSDALNGHEKSDGFSLNDGESAFSIDVKDSNDAQSLRQCDLSKPCVTHGSPEWVIQAYEEIPEDERQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXH2</accession>
    <name>A8PXH2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731263.1">
        <property type="nucleotide sequence ID" value="XM_001731211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXH2"/>
    <dbReference type="STRING" id="425265.A8PXH2"/>
    <dbReference type="GeneID" id="5855570"/>
    <dbReference type="KEGG" id="mgl:MGL_1446"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1446"/>
    <dbReference type="InParanoid" id="A8PXH2"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="379" mass="39797" checksum="E1A21C209584A005" modified="2008-01-15" version="1">MEQRAQRARNAMLSSSSGSETASLAPEFATSTWNRATWNGSGPASTRSSRWPSTETPGPEPEAGPSPSASASPVPKPSERVAEEMLARTPQNMGTNGAPEAERHVLTVGPVGTHGARDNVSLSQDTADSSTSLGARAGATFESNAEEANTMLQTQGKQGPGVDSASTELAMSPSSSSSTKRPGPPAEQDEMESTSAVKRFRSDLSSAEHEQPTSAGSAPASVVDEAIPHLHPQFRHETPIVLDASLPFVLTNPHATQETAEAAAAAAAAAAAAAAASATPTGIPMATGTLPTHAASTRRMKPKQEKARAAFVAAHAGQSYEQMVLEHAYSSDRLFWLKEAYNLTWRTGRWSQDEEDRATAALDKFCKVCTYGARSVRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXR2</accession>
    <name>A8PXR2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA ligase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA ligase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_1506</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731323.1">
        <property type="nucleotide sequence ID" value="XM_001731271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXR2"/>
    <dbReference type="FunCoup" id="A8PXR2">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXR2"/>
    <dbReference type="GeneID" id="5855630"/>
    <dbReference type="KEGG" id="mgl:MGL_1506"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1506"/>
    <dbReference type="InParanoid" id="A8PXR2"/>
    <dbReference type="OMA" id="DERSHAW"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="16">
        <location>
            <begin position="504"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP44109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="701" mass="77476" checksum="D7D8C436537B09EE" modified="2008-01-15" version="1">MPPKKQATLESLFSKEQPVPKRARVERDVHEGEHVHPPSTESAEAETTLNTKVEEDTASESRDGTDSNAISSSDKAVHMGHVESSVKTESATRTPMDAMQGRTSTGQRDATCPTDTAGAPIPYATLVDTFSKVEATSKRLEILELVTQLFLQVIYSSRGGDDKPLKAASENLLYTVYLCINRLCPDYEGLELGIGEGLLVKAIAQSTGREIVRIKRDFERLGDLGLVAHTSKKNQPTMFRAQALTVRSVFQQLKQIAAASGAKSQDKKLGIIKRLLATCSGEESKYLIRSLEGKLRIGLAEKTVLVAVAQAVMLATHDGKPHEPKQARDAGDANDAAKLTERLEQGTHTVKAVFSEVPSYDLLIPALLEHGVEHVQEHLKLSPGIPLKPMLAKPTKAIGEVLDRFEAHAFTCEYKYDGERAQVHGFRGSDGQLQVRVFSRNSEDMSVKYPDLVVQIPHCLRGGGENVQSFVLDAEAVAWQPRDEASHTEGRLLPFQELSRRKRKDVQATDMLCGSDATYEPSRRSINWLKLKKDYLSGTGDSLDLTVIGAYYGRGKRTNVYGAFLLACYDEDSETYQSICKIGTGFSEADLDAHYSTLKELEIPRKKGYYDLGEAKPDVFFEPRIVWEVLAADLSLSPVYTAARGAIDARGISLRFPRFIRIRDDKSPDMSTTPEQVASMYRAQAMATQSARGKDDEDEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY82</accession>
    <name>A8PY82_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731427.1">
        <property type="nucleotide sequence ID" value="XM_001731375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY82"/>
    <dbReference type="STRING" id="425265.A8PY82"/>
    <dbReference type="GeneID" id="5855734"/>
    <dbReference type="KEGG" id="mgl:MGL_1610"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1610"/>
    <dbReference type="InParanoid" id="A8PY82"/>
    <dbReference type="OMA" id="QWICLAG"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05677">
        <property type="entry name" value="M20_dipept_like_DUG2_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="610"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="861" mass="93575" checksum="F8319CE0B72A0327" modified="2008-01-15" version="1">MLVGMQSGEICAWDLDTFQPCARLIGHRSSVLSLILVDDYLFSASSDSTVRIWDAATLMPLALVFPASTNTGDIFCLAWDHEKHVLYFGCQDTSIQWLPVTRARLHEPTEPLPTLSSFDKFFDSRPRTHRQAAPTSSATAATATTAAATATQTVRSATATALVQHTSVEWLGGSADGSSGSKGGESAGHNNSSSAGDHVDTANDTAVNEPVSAVRMAVLSVDAAHVMPSAHNSYVYCLSFAHVNGETMLASGAGDEAVRLWRLHPHTASPMLFRTLVLPHPSGDAVLSLAAWKGTLLAGKQGGAIDVWDMESYTPIRVLRAHTKDVLCLQVLAEGNAYVFWTGGADGLVCRFDRYFRCCGRLAAHANAVQSLALDPGRSKSSYSWLSSTPLLLTGASDARVRLWHYQSGATSIPPSMGSTLPGNTLLEHLSQFVRYKSVSRGPTMHAVDENFEDSRQAAHFLRSTLMELGASDVQLLPSGPGTNPIVLGTFHAPHPRKRCLFYGHYDCVPAGDGWDSDPWDLCGRDGYLYGRGVSDNKGPILAVAYAASELLYERKLDIDVVMLIEGEQESGSKPLQACLQKYKPLLGPIDTILVCNSYWLGERQPCLTIGLRGVIQAIIRISGLRADQHSGVDGGAEREPMMDMIKLLASLLDDQGRVTLPHFYDDVRAITSDDRAHLTALAQEASRITHAERLIALWRMPSLTVHQVTNSSTAHSTVIPKAVEASVSLRIVPDQNLQAIQTQFHRTIHSHFQHMHTPNRVDVEVFHCADWWLGSTVGPAWDALVAAVEAEWGSQVRIIREGGSIPGMALLEKELNAKALHLPMGQASDHAHLPNERIRLVNLEKGQAVVRRFFVALGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYH7</accession>
    <name>A8PYH7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731481.1">
        <property type="nucleotide sequence ID" value="XM_001731429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYH7"/>
    <dbReference type="FunCoup" id="A8PYH7">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYH7"/>
    <dbReference type="GeneID" id="5855788"/>
    <dbReference type="KEGG" id="mgl:MGL_1664"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1664"/>
    <dbReference type="InParanoid" id="A8PYH7"/>
    <dbReference type="OMA" id="MIDTRQA"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="43"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="258" mass="29819" checksum="AB3BAD0BF7F47238" modified="2008-01-15" version="1">MLPTSRDYGTEQDKVNCSFYFKIGACRHGDRCSRRHIRPERSHTILLSNVYQNPKYLDPDCRASDAELQQQFDAFFSDFFKGLSDYGTLIEMHVCDNVGDHLIGNVYARYETEDDAQRAVDGLNTRWYHQRPLFAELSPVSDFREACCRQNETNECNRGGQCNFMHLRYASPELVRELYQQLAVENRERRREAHAKHDFLRLGWKERLARERAEAAEMYGNDLPSANAHDWRKGSSGGDWRAEPQISDAANSASSVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYI4</accession>
    <name>A8PYI4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731485.1">
        <property type="nucleotide sequence ID" value="XM_001731433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYI4"/>
    <dbReference type="STRING" id="425265.A8PYI4"/>
    <dbReference type="GeneID" id="5855792"/>
    <dbReference type="KEGG" id="mgl:MGL_1668"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1668"/>
    <dbReference type="InParanoid" id="A8PYI4"/>
    <dbReference type="OMA" id="RDYPYGW"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="397" mass="45330" checksum="4E3FBF6296C75226" modified="2008-01-15" version="1">MERDLREEHKAHWLSRRKQGARLRMIFIAIKRLLLCRYGPGPYGSSNANEEATGSVRHTCEATAYPAAHMSSTKSFDWSEETLTDLRLELEKLVVLDFLMRNTDRGLDNFMIRYNPQPAPGERRITIGAIDNSLSFPHQHPQGLRDYPYGWLFLPAGLIGQPFSDETRRLFLPKLCDPVWWAGTIEGLRRIFSQDAHFHERTFQHQVSLLLGQGWLIVQCLRERNEGPIELCARPKCLIHSSVQMMTRKELDAHTVTDLVQGSIAFPSDKLHEHEDTDERPTSTRAIEFNPRKHDSKPSRLVQSLPTTMMSSSNPLLSGTSHDSRAIDIVERMAKTQKRGLHSPKPYESPRELPSAKASHRMRPLDLDISASVSTYPVPVLVETLEPFTRKAWPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYM8</accession>
    <name>A8PYM8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1691</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731508.1">
        <property type="nucleotide sequence ID" value="XM_001731456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYM8"/>
    <dbReference type="FunCoup" id="A8PYM8">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYM8"/>
    <dbReference type="GeneID" id="5855815"/>
    <dbReference type="KEGG" id="mgl:MGL_1691"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1691"/>
    <dbReference type="InParanoid" id="A8PYM8"/>
    <dbReference type="OMA" id="YVTHERE"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="127" mass="15149" checksum="6D789ADE4AE4EE3F" modified="2008-01-15" version="1">MQHFVETRLNLDFDTQPLFNWNTKQVFLSLTASYDSPRYGTQDVVVWDKIVRNDDEKRIRISYLRNKYGLREYSKSFENVTSLDFRIEWNVMPFVGLMQRGVTPRSDPYALHQDPQLRKQSPALLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYM9</accession>
    <name>A8PYM9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731509.1">
        <property type="nucleotide sequence ID" value="XM_001731457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYM9"/>
    <dbReference type="STRING" id="425265.A8PYM9"/>
    <dbReference type="GeneID" id="5855816"/>
    <dbReference type="KEGG" id="mgl:MGL_1692"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1692"/>
    <dbReference type="InParanoid" id="A8PYM9"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="122" mass="13926" checksum="5DE64F17C4781375" modified="2008-01-15" version="1">MPSKDIADNLYYNRDFRRKYPQTDVVTQQHLTELLLAAPNEDGTKSLPTPESQQTTALTRPDDLASPTAFTQVLEQVHMESQHKYSPSNMPPKFPSTPPQHILKLQKGALPHDKYDYFPAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYS9</accession>
    <name>A8PYS9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731535.1">
        <property type="nucleotide sequence ID" value="XM_001731483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYS9"/>
    <dbReference type="STRING" id="425265.A8PYS9"/>
    <dbReference type="GeneID" id="5855842"/>
    <dbReference type="KEGG" id="mgl:MGL_1718"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1718"/>
    <dbReference type="InParanoid" id="A8PYS9"/>
    <dbReference type="OMA" id="PFAHFQH"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727933" description="J domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="416"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="523" mass="58319" checksum="7D49716E1D6343B0" modified="2008-01-15" version="1">MVSLWQLSVLLFIFVLVVQAEELTASEWLKRANAALTSYDYAGALEAFDQAIGLDPNSYLTYFRRATAQQALGRTSAAIQDLMTTVERNPHFGKAYLQQARIELKEGDFSLALETLNRMSSNGAKSLQKDGKQAEELLEEVKRAQAFEKKLGQIGSKHADDCITLADKLLQLAPNSVFARKQHAECALVLGQLQSAVTDWTRLSKMAPSPDLQLRLSLLSYYILGTRGSQVQDAGLAHLKACLHEDPENKLCIRAHKQLRKIDKALQKARGFSDNSKWTAVVSALKGAKVGGPTIYDEIQQVILDAVSSGILPKTIKNPADQSELLHEIETLYCRAYVEQEMINKAMPWCDKLGAVDPRNEHVLVAKGEEQMNQGNYEEAVRLFSQASEVSQSSGQKIRSRLAKAQKLLKQSKSKDYYKVLGVSRDADQRTIKKAYRQLAREHHPDKGGDQEKMAQINEAFGVLGNTELRERYDQGDDPNDPSGGQEASYDDFFAHAGHPFAQFFQQAHFQQGGGAHEFHFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q086</accession>
    <name>A8Q086_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730998.1">
        <property type="nucleotide sequence ID" value="XM_001730946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q086"/>
    <dbReference type="STRING" id="425265.A8Q086"/>
    <dbReference type="GeneID" id="5855305"/>
    <dbReference type="KEGG" id="mgl:MGL_1997"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1997"/>
    <dbReference type="InParanoid" id="A8Q086"/>
    <dbReference type="OMA" id="EYTHEQT"/>
    <dbReference type="OrthoDB" id="2152680at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="66265" checksum="1A48360C92565176" modified="2008-01-15" version="1">MSSVTHIRGVFVAEFHIRHGNAIVFQDPPDLDTDGLEWKVLPSGAHTISRDAIYFSYGHDMMGIAAYHARRLSNEEGASQQRGARCISIGVILPCPQDPSGQLRNLLPHLPVLAQLADDVAHGLKAPGVALYNAQYAPVHRMSISPTLEQLSYDPATYMLSMHSFLGPLMAPLIKLLLLPRRLLIYAPAPVERAAIVAFNLAELVHAAFVYAVHVPGHVRVHGMLTLHDLDAWKQLTFAAESAWIAWTSDRILLDKTDAYDVCLDVSALMFPSAVASPSPAKPLARFVKHATLQPTNLSWSTRDLSLFMELAEQERRYQDLLESEGRPNFDAWCHAEHLPSSCSLHVSMATPWRYRQQDARMLLVGYLVVLVASIRFWLTEWWLIRSQLHVLVPVSLVMPLGVRGDGGLSTGIVDLSEDAVSADESRTCMSQRPCWTAATAAGESNDCMSGSNESVDPLIAAYGLPQSGKSPRNSSSRLSAPSILSRRSSLHNDRSIIPAHPRYDPSDAPHLPLESMTGIYIRARHIQLSAFLEERISTLPNTNESSALLFPRTVRMTSSMFERLGLDAGSSIDRAWIQSLLTPHSCSLQVSRWPWFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0F8</accession>
    <name>A8Q0F8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731027.1">
        <property type="nucleotide sequence ID" value="XM_001730975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0F8"/>
    <dbReference type="STRING" id="425265.A8Q0F8"/>
    <dbReference type="GeneID" id="5855334"/>
    <dbReference type="KEGG" id="mgl:MGL_2026"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2026"/>
    <dbReference type="InParanoid" id="A8Q0F8"/>
    <dbReference type="OMA" id="HALVCRI"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="2">
        <location>
            <begin position="233"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="462" mass="52370" checksum="8BB61B0A51F80AC6" modified="2008-01-15" version="1">MNPPDEPYTPPLSVKVMRIATPSLASRVVPMFETCMESGVVDEPSDHNNTPHRQECVEYLDPHIWDVIKSTYARGSDEIFTNAPITARDVSYTDQLLLPASFGSVSVGETFQAVICVSNTSMMPIQGMRIKVEMHTDKTDSFPPSSHSLNDVSLPSLAPGAQMTALARHSIDKLAMHALVCRIWSDRHTSQGIYPHSFSKQYRFKVHPPPFLMRSEVHTNDTLSFYHDRSIREQTLVLVSVHNTSSRPLRLDMLSIDPDQSWSASAPKLDHMPLMPKDVRNFVFTLSPRETMSPLHFREKLQSAEHTRVACTVPLGHIRIAWRVPGGEMGRLRIGTIQRTTYLPCAVQGMYPELFLDRHDAWLVDEPCHVTMHLHIWVLDLALLRTRLDIALEIDDAWHDILVLGPNRHTASLELLEHTTLEVPWTLVPLRRGLASSGGFILRRVDTNSTLRVWKNVIQFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0G3</accession>
    <name>A8Q0G3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2028</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731029.1">
        <property type="nucleotide sequence ID" value="XM_001730977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0G3"/>
    <dbReference type="FunCoup" id="A8Q0G3">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0G3"/>
    <dbReference type="GeneID" id="5855336"/>
    <dbReference type="KEGG" id="mgl:MGL_2028"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2028"/>
    <dbReference type="InParanoid" id="A8Q0G3"/>
    <dbReference type="OMA" id="HRVCHIC"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="559"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="766" mass="83178" checksum="B509F0D475C663D8" modified="2008-01-15" version="1">MTRGGQARGGGARGGHRGGGNRGSSGHRRGGHGMPGHTRGGRASGQSAAPAASTSKTENHSAVNHEAGTADEAQPALQAKDAGTAADDGADTAEAGHDEEDERDICFICAEYVQLYSLPPCDHRVCHICAMRLRALWKKRECTFCKGDATRVIFTPNDTKSYGAYTPDELPFVDEKLSVYFENRQDYEDTLSLLRFNCPNTKCEAMCSGWSDLKGHVKREHSRLLCELCIRHKKIFSHEHSLFTAASLQAHLSSEHRYCEFCHQHFYSDDELWVHMRDRHEQCHICKARSEEERWNYYRDYDMLEQHFRKEHYLCLARDCLETKFVVFENQMELQVHQVEAHGHTLSNRERRDALRVDTRFMYDDGGAGGGSSSSGRRPARGKKPANATQASVNINANTPSTSTQRRAQFGRSLTTASGGGQDGSNEPSEDDRYWSTVLTVLNDSKIKLTSCKAALRAYSLSETNVHDLLKTLTNLTGDSAHSMDIGTTDLVVQSMCEMLKHTEKRSELLAAWTAIKEEHAPFPSLPASQGPHSVRSLKSAASGNARVWNSVARAASSAPSASASSSHRMPARTPDHFPTLSSANASRVPGSAAHTRGVQRRVNTAAGSTPWSGSGNAGSSGSGTRNSSVMSPVAFPPLGSGPVQRTPQSVHVSSMSKSKTPALPANHFPSLPTSTAHAERQAQKRELFSQPRVNPLVPQAPPTRWGSGPSLSSSPAGQEAFPALGDVRASLPDSNDALASSSAGSGKQRRRKGVLLSSVGSMHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q133</accession>
    <name>A8Q133_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_2119</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731120.1">
        <property type="nucleotide sequence ID" value="XM_001731068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q133"/>
    <dbReference type="STRING" id="425265.A8Q133"/>
    <dbReference type="GeneID" id="5855427"/>
    <dbReference type="KEGG" id="mgl:MGL_2119"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2119"/>
    <dbReference type="InParanoid" id="A8Q133"/>
    <dbReference type="OMA" id="VIMLDIN"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="15">
        <location>
            <begin position="198"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP43906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="326" mass="36904" checksum="0231AFEED65FBD37" modified="2008-01-15" version="1">MMVTRSFRLPVQLALSRPRMLLIRSQRAPFVSRSHPARSNATNPPPPPPQNDSPNSGSPSDLDAKKSDAPFKKGIQLDIDASSLVDAQSISAPSGEDGQDGSSTQRTNAKARSDSNSNQSDFGQRIMTQGAIIGCILLAGYGVWMLGRDLDEREHEVFHDKEGVNSFFGRLKLRYDVMREGVNKPVWDHLLPDPLPYPYSRPYTLVLDLDQLLVASSWSTSHGWRTAKRPGLDYFLGYLSQWYEIVLFTTQPFYVVEKIIEKLDPDRRYIAYQLFRESCRQSDGKLVKDIRHLNRDPKKVIMLDINPEHVSLQPENAIVLEPLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q195</accession>
    <name>A8Q195_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730755.1">
        <property type="nucleotide sequence ID" value="XM_001730703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q195"/>
    <dbReference type="GeneID" id="5855062"/>
    <dbReference type="KEGG" id="mgl:MGL_1754"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1754"/>
    <dbReference type="InParanoid" id="A8Q195"/>
    <dbReference type="OMA" id="ICKDKRI"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="155" mass="16921" checksum="4CC3B81C8C92EC91" modified="2008-01-15" version="1">MDVDVFEDALFTVFEHHQPARGDPGTTGTYTNEAIPPDAHGRRSITYRIPEVSNENTRLFAHHQWDAGVHVTDLIASYAPVDVRGKRVIELGAGTGLPSLACAVLGAQHCVVTDYPDPYILASLEANVEALRERYSTSIQVAGLAWGDEAQETYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1A0</accession>
    <name>A8Q1A0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Erythromycin biosynthesis protein CIII-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730757.1">
        <property type="nucleotide sequence ID" value="XM_001730705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1A0"/>
    <dbReference type="GeneID" id="5855064"/>
    <dbReference type="KEGG" id="mgl:MGL_1756"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1756"/>
    <dbReference type="InParanoid" id="A8Q1A0"/>
    <dbReference type="OMA" id="DYGQANV"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF151">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="339"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="483" mass="53877" checksum="19CE02C6D49B4645" modified="2008-01-15" version="1">MMSGASVLPRVQKIQKLGSYPVQTEANPTDSMLKTYPIVFVSLGTSPVLSYLDYVDEQPERFHSHCCAKPGKVMGWVQLYKEVVPDSTDEYLRMTHLVRDYVEKFDADMIIVDNFSPFAVDGVRLTKRPFIETAPGSVMGVASQVNPFKQPLPMSGGRSGEGGLFVILSNFIFIFNWLYFYLFDPWSTRRRKFRKEVLKLSTPNPLDDAIMPPAPGVLPQQISTLAFSVAGLDIYASNAYDKSVFFVGPCFVPNALPDTNANAPTPVDDPVLAWMDELYAQNKRVVCINMGTIYYYLRKDYDNLLRALHMLHERMPNVAILWKIPDRSQDVQPIPKAEEANLPSFIYRVAWIPDMFKVMQHPALGVVMHHGGGNSLNEALAYGVPQFCVSQWVDTHDIGLCIQNSGVGLWADHSPEFIPEDVSSKLATLLEDKGLGFRHRALAWKLKTQQAGGTSFAADVIQSYVSGYTFEGGNSKAPVANAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1X2</accession>
    <name>A8Q1X2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730853.1">
        <property type="nucleotide sequence ID" value="XM_001730801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1X2"/>
    <dbReference type="FunCoup" id="A8Q1X2">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1X2"/>
    <dbReference type="GeneID" id="5855160"/>
    <dbReference type="KEGG" id="mgl:MGL_1852"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1852"/>
    <dbReference type="InParanoid" id="A8Q1X2"/>
    <dbReference type="OMA" id="MRTVEQW"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="10"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="313" mass="35417" checksum="7EAE97C636679C7A" modified="2008-01-15" version="1">MATTHAPPAVEVHNLCYSFATSPAPALEGCDLILERGSRCLLIGANGAGKSTLLRLLAGKRLCEANIRVFGQDVFRAPPRGITYLGTEWAMNPVVRSDISVHDFLNSVGGFRFSERRDHLLDLLDVDLSWRMHMISDGERRRVQLCMGLMEPWDLLLLDEVTVDLDVQVRCDLLDFLRKESESRGSTIVYATHIFDGIHEFPTHLVHMQLGRTTTHAPIPWPLRLDSHLPSEILASLPANIQQDVASMNPQVTYPLTLLSLALAWLREDRILRDQYEQSRGVKRGRAGRLPAEETKDAKKFFSQYDYYSNYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2B2</accession>
    <name>A8Q2B2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2183</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730729.1">
        <property type="nucleotide sequence ID" value="XM_001730677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2B2"/>
    <dbReference type="FunCoup" id="A8Q2B2">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2B2"/>
    <dbReference type="GeneID" id="5855035"/>
    <dbReference type="KEGG" id="mgl:MGL_2183"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2183"/>
    <dbReference type="InParanoid" id="A8Q2B2"/>
    <dbReference type="OMA" id="ETRICKX"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="68"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="245"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="309" mass="33287" checksum="E82580A424AD2CAD" modified="2008-01-15" version="1">MSSSNELVEAETEVEAADEMADEIMGPLPVSKMEGMSEQKVDKILSEAAKLVPLGFTTATEYHQRRSDLITITTGSPALDLVIGGGMETGSITELFGEFRTGKSQICHTLAVTCQLPVDMGGGEGKCLYIDTEGTFRPVRLLAVAERFGLDGEEVLDNVAYARAYNADHQLELLVQAAAMMSESRFALLIVDSLTSLYRTDFAGRGELSARQTHLARFLRTLMRLADEFGVAVVVTNQVVAQVDNAGFGGMDTKKPIGGNIVAHASTTRLSLRKGRGNQRICRVVDSPSLPEAEAVFAIKPEGITDPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2K0</accession>
    <name>A8Q2K0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730407.1">
        <property type="nucleotide sequence ID" value="XM_001730355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2K0"/>
    <dbReference type="FunCoup" id="A8Q2K0">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2K0"/>
    <dbReference type="GeneID" id="5854709"/>
    <dbReference type="KEGG" id="mgl:MGL_2202"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2202"/>
    <dbReference type="InParanoid" id="A8Q2K0"/>
    <dbReference type="OMA" id="CPYDLFQ"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="102"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="244" mass="27782" checksum="42224D8522AFB5EA" modified="2008-01-15" version="1">MGRKAEVQRVALERLMGPEMMGTAEKDVHFTDPKKMDLGPCPKSHLPRYKEMYDAAVERGETFPQIVADFQRNIHMFVGDIDRKIGSNKRRLEQTPEEMERFNAMMRDINEVQEAITAATNEMESLGEQGRVEESLKELEKVEALKAERADKEKELQTLQENSGASGHQKLRVCDICGAYLSILDSDRRLADHFSGKMHVGYQRLRDLLVDIQRQQRSPGVPDGSSNAARDRRRSRSPPTGRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2W7</accession>
    <name>A8Q2W7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730461.1">
        <property type="nucleotide sequence ID" value="XM_001730409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2W7"/>
    <dbReference type="STRING" id="425265.A8Q2W7"/>
    <dbReference type="GeneID" id="5854768"/>
    <dbReference type="KEGG" id="mgl:MGL_2257"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2257"/>
    <dbReference type="InParanoid" id="A8Q2W7"/>
    <dbReference type="OMA" id="ICVMSSS"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="5">
        <location>
            <begin position="214"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="842" mass="92750" checksum="98837D53551678BB" modified="2008-01-15" version="1">MKHRISTWADDLEVSQIRTLPVPSLAQLLHTNERIASVAHNAAERFPSLHVRIAARPTPSAHVCLDISVWRTFVWDERIHGASLPIVWWVQDATQRVVYMDRLTLRPTQGSFDKGSTDNVSHPFEREHGQYQMQVYVPLSPADVRPTSEAACEFVWSSLHWLHAEGSVFMNVDHLECPSPTPSTTLLPLPLLPLASLQDMPLADGLGHVHTLNAIQTQVFHTLSHSRANVLLCAPYGSGKWTAALFAIARAFKQDSEAGGAASSSKNSAASSGMILIIEPDAKRIGSRIDTLTKLAPFLGDIHSVHASSTLEHCMPRSIVIMTPADAANALSGATAAHAQFPTLSLVICLHIHKLTPAYELAIMQIRRAQPSRCIATAQCLSTAASFAAWLHIPTHAMSAFAPSDTPYPVSMSFDTVDIPYSETLVRAYAKPAFDCLETHEGEVGLLFAPTRAQCITAAQELTARFAMKGFTAHPDVESAAQSIQHQGLAHLVRQGLAFWHTNLSERDRSTVERLADMRWIRAVLCSFEAAEDVPIQTSLVIVLGTQYTTHASRHVQEYSLEQLWSMQRHAVRPNSTSGEFHVLCQQQMRPSLERLLQTPLAVESSLSERSPSVLEALAHEVMAQRVMTRRDIVMWLSTSYLAIRVRSNPAWYGAPGENERTDPSTHVSSMADALLAQGERLSLWHVDENDHIHASFIAQTAPPGGIQRLCAFVDTVLLWRKMPDAVHHQDIFNVDGVEASAFDNDGSIAREADQANAKVTQPEGLQENCAKTMLEAVDALERPTLPRIVLAHWLTPLVSTRTLYELDQVLILKAGGHAAGRIMQIRHAILRRIMSGPGTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q326</accession>
    <name>A8Q326_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2297</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730501.1">
        <property type="nucleotide sequence ID" value="XM_001730449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q326"/>
    <dbReference type="FunCoup" id="A8Q326">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q326"/>
    <dbReference type="GeneID" id="5854808"/>
    <dbReference type="KEGG" id="mgl:MGL_2297"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2297"/>
    <dbReference type="InParanoid" id="A8Q326"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="8">
        <location>
            <begin position="94"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="539" mass="59197" checksum="19B8B08EB8C1CFC2" modified="2008-01-15" version="1">MEPSPTHEDHCDLFPDCDTVVRLESMRCGLEQLSRVCPVAGMDPFSMHRALPGCTFTLLSDASDVLCMPNEWLDTLDELASLPSRVPGIVAVRGLKNSGKSTCARMLLHAFLTRGEHRFVAYMELDVGQPEFGPPGMLCLHVFDSQREHGLFAPGWCTARMPVRAHFLGDITPRDDPARYMAAVSDLVDTYRSQYQFYQSAQRVEEQLYLPATSEGTLRADRTIPLIVNTHGWLKGLGLELVQHVTATLMPTHVLDVGPTPCPDATHTLVPFPETLDGRASVPQRRLNAAESRTLSLLTYMHMTRLASPGVRAQWNFASALVAQRPWVVDVSSGLGAGFAALDTGAHVDEALTLLAMNGALVAIVQAPEHVADGETKVPDVWRTAIQRGRDLLTRTMPPMAPTLGLALVRSINMEQKQMHLLTPISGPDLHQRIYKTGLPIGLLQGALDLPFWGALDAETYADVMQWRRGGQPSTHLAGVPCADVPYLLWPSEFLARATHCEDDAALSPSGSSAEPLGARPRKVRRNLMRRRHKSTALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q362</accession>
    <name>A8Q362_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730523.1">
        <property type="nucleotide sequence ID" value="XM_001730471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q362"/>
    <dbReference type="FunCoup" id="A8Q362">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q362"/>
    <dbReference type="GeneID" id="5854830"/>
    <dbReference type="KEGG" id="mgl:MGL_2319"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2319"/>
    <dbReference type="InParanoid" id="A8Q362"/>
    <dbReference type="OMA" id="KYSWMAT"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="80"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="286"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="410" mass="45524" checksum="5DF2BD3C3EE70216" modified="2008-01-15" version="1">MRQQQQQQQQQQQQQNSQHQPQQPPQQQQQQQHQSHLSRFSPLPAGQNQSSAQSQSTSQPSQVPASSSNPQGSSYDQLIDVMGYSGVDLRAEEAFIQQNGAHWDDAHAASVINSAGLAHALYLNVYPLSSMVHRIAKQYGLKVDATTLDYLSVATRMRFRNLLESMIRASRHRAWSSHQRNPPMYSELLPDGSQKAMYHEEMLSNPMKQLAGIEKAERIEEGNWRRMRIEREENEAAAMEAGGDDATPKNKKRSSTSSRNLSEDVRKRLADSTAMRHLGANNVTSKYSWLQSPATRTPSRVRETGEQQSHQQQAESTSSPKTNSSLPKPKFAPSAGLRAPAAQAAHAGAWSDVAMRQAAKREQERIARARVTMHDALAALEREQAGGAGHGARRRALYLAQAYGGSRGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q368</accession>
    <name>A8Q368_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730527.1">
        <property type="nucleotide sequence ID" value="XM_001730475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q368"/>
    <dbReference type="FunCoup" id="A8Q368">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q368"/>
    <dbReference type="GeneID" id="5854834"/>
    <dbReference type="KEGG" id="mgl:MGL_2323"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2323"/>
    <dbReference type="InParanoid" id="A8Q368"/>
    <dbReference type="OMA" id="QEPIMAY"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="60"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="560"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="730"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="806" mass="88061" checksum="957409E6CD8B2E58" modified="2008-01-15" version="1">MDQRGFSPKKETSPLKRSAIAYGNGPASGNMSAQMAMPSLRTPSGMNVARPTEVSVPSEPIQTYLRIRPPSIDERDNRESSAPSYVEVLSDTQVMMHAPPEVSLSKSRLRTNPAAPVKYTFSHVFAPHLQEENNASRSQVQADFFTMTTLPLVQDVLKGKNSLVFTYGVTNSGKTYTVQGLSRNGEAGILPRALNVIFNSIHGRECTKAVRPMGLNGVQPGVSDPSQSLLSGRIRPRTRLKQRLNPIMGQGSTSIDIANAINTGISDTAKQSDESWQNHATKVDVLENVRYSVWVSYVEVYNEKLYDLLESPTPSLLSRVEHDVPGADTDLGALASPSVPAAARRPLLLKSEAETGGKYVSGLKEIKVNNIQEARELLRCGQENRSVFGTMANQSSSRSHSVFTIKILRENTSVEFASSDSAGLSRKYSVSRLSIVDLAGSERISNTDISTGPRLKEAGSINKSLMCLGQCLETMRKNQARAGIGASLSSSRSEESRKRRPSIVPFRHSKLTELFQSFFMGDGKVIMIVNVNPSGTGFEESSNVMRFSAMAKEVGIQVSSPASTATVGPSTSCSDSLGSQHVSDAPDASGLDASFNTEKLNTSDDDVDNDDEEQDEFVNMLLAENERLRLRCERAENLCRIVEKNVRDEMGQQLEAGLKNMQRFYERQLQAEIDASDAFMDRKIDLFARLSQAVEHEPSSAESSACDESEDAASPAAPSQFLAENHDYVNVSPGSQKQTSRKSSLKSTVTSSDESHDTLLVANTPSPSRRFRKLAQRPAIQTDEMDQVAFGLVDAAARTNTHRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3H8</accession>
    <name>A8Q3H8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730610.1">
        <property type="nucleotide sequence ID" value="XM_001730558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3H8"/>
    <dbReference type="STRING" id="425265.A8Q3H8"/>
    <dbReference type="GeneID" id="5854917"/>
    <dbReference type="KEGG" id="mgl:MGL_2406"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2406"/>
    <dbReference type="InParanoid" id="A8Q3H8"/>
    <dbReference type="OrthoDB" id="2585512at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39145" checksum="438A6A91D5700F66" modified="2008-01-15" version="1">MSSQMWEPKLLVSHLPRTVETLSLIMPSREVVHELVHIAKHLDNRLFSLQLLCMNSAVVTDGLLCDLAPHVPRLSRLSLVGCKRVHGPGVRALVNKSIRDLSLESVALDVGVLATLAPDVVHLKRLTLTPPRHVRDMKSFYDEASVLIDACNALECLTLYARGGSKPVVGHDLGSTGDTSRLGEDQADLDVQVNHVVQPPSSQQQLTPSSPYISTLYMARLCASSSAHSLKTLRIQGLGMSLDTLSMLAQSPLQHVLRDLDIHLYEDNVPKLIACIASFERLESLHIFSDLQSHAQLSDGDILRLAREAGGEWFCQIGFQNRVWHVRSTRQGRELIPWDKSAGTFPQSMLVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3I1</accession>
    <name>A8Q3I1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein L7/L12 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730613.1">
        <property type="nucleotide sequence ID" value="XM_001730561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3I1"/>
    <dbReference type="FunCoup" id="A8Q3I1">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3I1"/>
    <dbReference type="GeneID" id="5854920"/>
    <dbReference type="KEGG" id="mgl:MGL_2409"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2409"/>
    <dbReference type="InParanoid" id="A8Q3I1"/>
    <dbReference type="OMA" id="DPTQHRS"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="121"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19165" checksum="D28444C0343E93CF" modified="2008-01-15" version="1">MMIHASAAAAAARRAAMAVPRARPTMQVRMLSRSMRVCEGTTTPSSPKITEIVDSIEKLTLLEASELVQELKTRLNITDIAMPAAAPAAPAAAAPAEEAPAEEKPKEKTLFTIKFLGLGSDSAKAKVIKEVKAINTSMNLVEAKKFVESAPQTLKENVTKEDAQKIKEAVEKAGGKIELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3J2</accession>
    <name>A8Q3J2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730624.1">
        <property type="nucleotide sequence ID" value="XM_001730572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3J2"/>
    <dbReference type="STRING" id="425265.A8Q3J2"/>
    <dbReference type="GeneID" id="5854931"/>
    <dbReference type="KEGG" id="mgl:MGL_2420"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2420"/>
    <dbReference type="InParanoid" id="A8Q3J2"/>
    <dbReference type="OMA" id="DENLYCF"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="133"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="189" mass="20569" checksum="5F57BB21ABC40A0A" modified="2008-01-15" version="1">MYDCAHVAYDQVYAHHQRLTEDLKLVNEDLVASASASLPKPPTLVEPSQLAHALLNAGIGDHEGESNDGKLRRKRASHSSSGDTARSAPSTHAGRTTAAVRGSSSNADGSDVRGGKADAADRTVDVEEERDENLYCFCQRASFGEMIGCDSDDCKYEWFHIGCVGVSKPLPQMWVCSDCLAKNKKRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4I3</accession>
    <name>A8Q4I3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730163.1">
        <property type="nucleotide sequence ID" value="XM_001730111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4I3"/>
    <dbReference type="STRING" id="425265.A8Q4I3"/>
    <dbReference type="GeneID" id="5854470"/>
    <dbReference type="KEGG" id="mgl:MGL_2545"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2545"/>
    <dbReference type="InParanoid" id="A8Q4I3"/>
    <dbReference type="OMA" id="AYENNQM"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="815"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="866"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="900" mass="101072" checksum="0EE8CCECB43FACCD" modified="2008-01-15" version="1">MKGVGNAGLRELMVEPLQRIPRYQLLIGNLLKHLPSTSPQVQRLQDASSAATLIASRRVTDGERLAAVLWSCQRTIDRFPPELVSLHRELLGCIDVDELTADTTQSKAFYTLGSVLGRRTRSSFALLIFTDALVLIQRHSSTPTHILLGVHEPDRLAEMMRSAQIGPHQNSRRTELSFAGMASLLDVSASGQGSQFTLEFKRPLRGAQNRVLTRHFVDAMPDAQSSHIPLFLDCLWQSQVIYRARGHALAARTNVTDSSKGPLSLFWTLFTRSQYDRFKSRDRLLIMLGSLDYSSRDAMARSSELFVNVELQEDVDECIAYLSRAWGAQTRQVTTPLTDLPRICADLLVLTTLPSTKPVVVPVEVSPNKPVRRAQSLHTERRNVPNVHRARSLMSERVRASIHESLEAVQKSECQELQLGRKRSVPLADLSNMSPKRRVLPSEAEGSENVPIPVQEAMPQAEPMDEQGTPNKRGPAQLSMYADDTLDLPNPFDERGAMPSSSPILPEPTKMEEPVAEILHEAVLDEPMHDVPGEQLPPESAVEPTHVHEEPNPSVSTQKPELEEEHVPFSLPEQEQAAPDAEPKAEPGQETMPVAGDNLLPDPTVGESASEPIPTNNSVADESQAPPPPPKELSKLKAPSVSEKEMHDMLRPLLEHIQVTPSHQPVVVHAKRGEVAESRRAEIVVPQPLDISQHQLETLPEERSGDDILYVPPTSETTDLATMKHAITSLNERILSLRRFRPSAQTPEWPDEWNAFKQAVKHLNVSWTKMERAYENNQMELASLRLTQPEYDTRVHLSQEEYSDLQNQCNMVLPLRLQVEKLTEQSESLKELERDTRLENAELYNVFNEELSKLYRHSFRPANEEIDTLREALVAAKKEVNDLRKENRFLRLHHTIGDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4N0</accession>
    <name>A8Q4N0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mis18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2581</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730199.1">
        <property type="nucleotide sequence ID" value="XM_001730147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4N0"/>
    <dbReference type="STRING" id="425265.A8Q4N0"/>
    <dbReference type="GeneID" id="5854506"/>
    <dbReference type="KEGG" id="mgl:MGL_2581"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2581"/>
    <dbReference type="InParanoid" id="A8Q4N0"/>
    <dbReference type="OrthoDB" id="74210at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034752">
        <property type="entry name" value="Mis18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16431">
        <property type="entry name" value="NEUROGENIC PROTEIN MASTERMIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16431:SF1">
        <property type="entry name" value="NEUROGENIC PROTEIN MASTERMIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51793">
        <property type="entry name" value="MIS18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mis18" evidence="12">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="125"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="328"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="410"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="205"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="464" mass="49767" checksum="BFF2D0E5161DC177" modified="2008-01-15" version="1">MKPSSSVLTTETSSPTSLDLNTPPLMVFQCHQCLTIVGDSVAWLLAQRQLGLIVLQEVTDKVLTLEFLTTSEDQDWERCKFAPLACAKCDQILGRFYKDTPPEWTIMRGAFSLYHSALVVYQLGTPRGTPHRTGDGRVDSDAGSQRLQADPRSLRPPDLMSADRRSSLSPPRSHASYIPSSYTVTRGPRSASPSLPPMTVPDKGSPAPLSSMMSSTSSPATTPSSFAKVSRPAQSSTSSPSLSAALAPSGRTTMLPSLTTTSSSSLTPNSGPPPASFSSGPMSYPSSTPSSVSGDKAESSRTDTDLEKIRTLLMGMGERLMRLEQYLPVPPSSTSYPSSTSSSSSSSTATSATSTATAPPPSVPSIIDDRSVQRHPHAAWDELRQISPVSTYPCVDASARRNSTTMCYPEDTLRRWPPRRDGSRSLSDTARRSLVLRPSPSWKSGAPPDDVNSRPFSPPDEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4R0</accession>
    <name>A8Q4R0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730229.1">
        <property type="nucleotide sequence ID" value="XM_001730177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4R0"/>
    <dbReference type="STRING" id="425265.A8Q4R0"/>
    <dbReference type="GeneID" id="5854534"/>
    <dbReference type="KEGG" id="mgl:MGL_2611"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2611"/>
    <dbReference type="InParanoid" id="A8Q4R0"/>
    <dbReference type="OMA" id="FIKQQKC"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF107">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="698" mass="77496" checksum="20745575727AEB5A" modified="2008-01-15" version="1">MAFRVIGRTPVVSISKRTLSTSSVSRFMPSMLARISPTTFQMQSALPRLPVPRLEDSLERYLRSLEPILRQKEVLGELPSGSTAESEMQQRRTWAKELIESGVGPRLNERLVDVDQTTENNWFDDRFWLLKAYHEWRAPLLVNSNWWNMFLPDPCMPAELSERVDAPAYTQEAIDLQNWDGIEYGLRRATWITYRATLYKIALDRQTIKPDASRAGAFCMHQYSRMFGVTRIPNRPADHNTATSISAASRHVTVLVRDNVYELPVIDEHGEIFPLTAIEKALQDIIADAKQAKGDGIPVMTCDDRDAWTKAREHLLSLGPQNRQSLQSIQTSLFVLALDCNNIGAPLGAKPNVGSEPSYSSAVGINTAGAGRLGHNRWFDKAISFVVEPTGRAGLSGEHSPVDALIPSFLSETVLAAPMPPPTENFPEKLEGVSLLETSPTWHKLSWLVDDQVRASIAAAEDTAKAITSDSDIGVLWYSEYGADWIKKVARQAPDAYIQMALQLAYASVHGRQTATYETASTRLFRHGRTDVIRSFSNEAFNFVQGVRMNKPAAELYKLLTDATTSHTRQTRDHSFGKGFDRHLMGLRLSFRPEDDGEVPKLFSDPLLGESASWKLSTSGLSAGDKFVGTGFGCGFPDGFGVNYLAGSKTLKFGLESKRSNPEGQGHPIHMYKESIANALRIMRTIVEQGAPPLEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4R5</accession>
    <name>A8Q4R5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730234.1">
        <property type="nucleotide sequence ID" value="XM_001730182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4R5"/>
    <dbReference type="STRING" id="425265.A8Q4R5"/>
    <dbReference type="GeneID" id="5854539"/>
    <dbReference type="KEGG" id="mgl:MGL_2616"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2616"/>
    <dbReference type="InParanoid" id="A8Q4R5"/>
    <dbReference type="OMA" id="NGQDHAF"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="128"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="563" mass="59244" checksum="D1248952152AF2D5" modified="2008-01-15" version="1">MAGSAGAHELPAAESLVSTPPRRTTRARRATTKATGSASDASSAATSSKSEGAPSTSTAKSTVSTTIPSSSLSSSPSKTPQKARASKATPSSQRTEPAERVHELPKRTNPRLHEVKSRQVKLQVIRREDKEIIIGRIKLPTVNGAEHGFLLKRFDTNAIAGSSMFRLAFPYADAEEESAEMTYLESRFDTDVANGGVIPPPRSRSSRKLTSDTTAKAAGTLPPGSTGVRLQGVWIPCEHAMSIASDYGLVEYAQPLIEATAILLPDEDAPVLNPDAETLATAAAASGSAVVETTGAPTPSDDTSPPALTSSLDVVSSNTLSNEAALGAADSPMREPLQVAEKDDTNRSAVSDVTEHGETPPQQADLVVPTRQKKRARVGEELQASSALSSNDSQSDVATNAEAVLARSQAARRSGRTAPAAASTDVPAPSVPLTAAQIDAQIREAQDFAAKIQRESVEQDETHSRPTKRLAEDDEPEDPQSVTVAPQASSQVLRRRRPLARAAGMLTAAGAMGIGAMAVYTGSINLPASVPHVFEQLQHVDYSSALQMIQQNIQNWGIASWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4V7</accession>
    <name>A8Q4V7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-aminobutyrate aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730269.1">
        <property type="nucleotide sequence ID" value="XM_001730217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4V7"/>
    <dbReference type="STRING" id="425265.A8Q4V7"/>
    <dbReference type="GeneID" id="5854574"/>
    <dbReference type="KEGG" id="mgl:MGL_2651"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2651"/>
    <dbReference type="InParanoid" id="A8Q4V7"/>
    <dbReference type="OMA" id="GAIETMK"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="46775" checksum="6ED628DC8259C57C" modified="2008-01-15" version="1">MSQAARFGARHITRGIGRMSQHVLKSGRGAFVMTDEGKRLLDMTSGIGVVNLGHCHPAVTKAAQEQCATITHAQVNIGYSVAQLDLVKELLTIMPHPSLDTFFLWNSGSEAVEAAIKVARMVTGRPNLIVVQGSYHGRTNATASMTRSKTVYSEGVSPFMPGVYTTDFPYYAHMFKPVNTPTDELVDFCLKRLELMLKQETSPRDTAAFILEPVLGEGGYVPAPSAYLHGLRSICDKHGIMLVADEVQSGFGRTGKMFAVEHSGVRPDMMTFAKGLANGYPLSGLVASKAVMDVMPPGSMGGTYAGNAVACAASRATIETFRRERVLENVAARSEQLMKALTNMRQQPFGHVIEDIRGLGLMIGVQFQSNSSEPIAPRLSQACLKRGMLLMSTSSFDVIRWIPPLTVSEEELAQAVEIFQASLEEVVSQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4W7</accession>
    <name>A8Q4W7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_2659</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730277.1">
        <property type="nucleotide sequence ID" value="XM_001730225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4W7"/>
    <dbReference type="FunCoup" id="A8Q4W7">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4W7"/>
    <dbReference type="GeneID" id="5854582"/>
    <dbReference type="KEGG" id="mgl:MGL_2659"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2659"/>
    <dbReference type="InParanoid" id="A8Q4W7"/>
    <dbReference type="OMA" id="CRPGDFN"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="128"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="322"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP43063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="625" mass="69649" checksum="2B56F3B30AF981D4" modified="2008-01-15" version="1">MAPSRVTATRARQSPTLPWSALHDRRAADSAVQAAQPLPRMHGPSYHRPYLLDQPDAVQRLLAWFDHKQHDRLMPWRQAWIDPNEDAPESTRVKRARAHETGTHRSAHNIVQEQIQRRAYEVWISEIMLQQTRVETARSYWLKWIEAWPSIDALADASVDDVLAAWRGLGYYGRARRIHEAAQKIMHDPSMKGQWPEYAHELCEKIPGVGPYTAGAISSIVFGHAVPILDGNVARVLSRQTGLYADPRSKSTNDLLWYMARMLVEHVAPNHRSDVPGRWNQGLMELGSTLCTPTRPACDTCPIQSTCAVYAESILYERAPVSSPVAQSTTMRSDPSDIEDTCSWCQAVPDPADSPNSATDPQVAPTKNPRSTKSKLKSSPKSTPKRALTQTTLWGCPADDKLDRSRESDATLSSSSALLRAKYIQLFPMRAAKQAPRVESRVVCIVRTTSLSSATPVFLLHQRPDTGLLAKLWEFPTVVVSPPGDQSTDNAKEGEGDYCDNRVNHTQGDIEVYKQQALSFVASLRPPAAKSAPDPSDNKHVTITARLQVDHIQPLGFVRHEFSHLHWHMHVLLVDVTVEGQGTCSSTNNGAEMDGHTQQWRTAHEVEAASMGTGLRRCWSLVQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4X9</accession>
    <name>A8Q4X9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730286.1">
        <property type="nucleotide sequence ID" value="XM_001730234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4X9"/>
    <dbReference type="GeneID" id="5854591"/>
    <dbReference type="KEGG" id="mgl:MGL_2668"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2668"/>
    <dbReference type="InParanoid" id="A8Q4X9"/>
    <dbReference type="OMA" id="FTWPTNI"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727983" description="Phytocyanin domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="24906" checksum="FC3FCD8DFC7F0519" modified="2008-01-15" version="1">MYAKSFSILALAAASLVAAEDFTVATPPYVQQCSPLKITWKGGEPPYRPFITAPGKIDDVKENLDETSDTSTTWKVTIPQGQKFTINICDNSGQCQASGEAGPVGKGDDSCINGGGNKGGSSGGGGGAAAAGGGGSSGGSSGGDDKKSGDGDDKKSGGDDKKSSSSSDNKSSSSSGGKSSSSSGQSSTGGGSGGGSSSAQPSSTGMGGGSDDKSGQDNKEDGSDNNGGEKKGDDSGSMSFSGVPAVVAGVVGVVVAALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q528</accession>
    <name>A8Q528_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2706</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730324.1">
        <property type="nucleotide sequence ID" value="XM_001730272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q528"/>
    <dbReference type="STRING" id="425265.A8Q528"/>
    <dbReference type="GeneID" id="5854629"/>
    <dbReference type="KEGG" id="mgl:MGL_2706"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2706"/>
    <dbReference type="InParanoid" id="A8Q528"/>
    <dbReference type="OMA" id="KRTGWYH"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="14">
        <location>
            <begin position="601"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="262"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="767" mass="84798" checksum="F6E74F6AFA8DED11" modified="2008-01-15" version="1">MDGMITLTQACLSEEVIRAKEREASYSQIYGVILPPPADDESNPLMMAIPHLKDPNDVSSFFSMISRASFDNPSLSVTSDASAESLDEHAWHLLEQYRASLVSEMAAIIRNKQEEWLEHVQKARSQLLLLAQHIGPSKPAVSTGSSTPQSDVEHPKSDLFAKRFLEETLVPPQRSTGTLGASLARYSETHTGAKSESPVEHAPSPSPPYVNQSGARLMDGGNSSDHSVAVNAASTAAAAAAAAATSSSAAVLESSAVSPLTLSMSGGLKDAAPQEDMGEQDDGSGKEDQMFQTDEDMTAARPVSQTGRGEHEPFARHVPERTVTDEKVAELLSSGLATSFSAISVAQQAVNFPRSRLEQLGLKGAYDVPDNHHVRRLPPVPRKKRSFLQNMHDHDEDLALAGAVAAHAPSHRHNNAAVASNDAGHHPPTSKRATEPDTQLSLATSVPYHPLIPVRNLRRREMTEGIDHEPKTSLPCNENRMVPSLLQALREKNSMSPVSKRTTGFQLPSARPIPLTPKPRSVFHVTVNDELPPIPQAPSRHLRLDPSSGGSPRALNNVNLEAMKDSEVFDESMNKALYFMHYLQNLKLAKRTGWYHHNVPEPESISDHMYRMGVLAMLIKDDKIDIRKSVMMALVHDISEALVGDLTPHCQVDKDEKSRREHEAIHILTHDLLGDTDASHTIFQLWREYEERQTREAVLVKDLDCFELCLQAFEYEKLHDIQDLQQFWLGAAHKIKHPQVQAWLAALLRKRRVLWESRGFSYDDATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q543</accession>
    <name>A8Q543_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730336.1">
        <property type="nucleotide sequence ID" value="XM_001730284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q543"/>
    <dbReference type="GeneID" id="5854641"/>
    <dbReference type="KEGG" id="mgl:MGL_2718"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2718"/>
    <dbReference type="InParanoid" id="A8Q543"/>
    <dbReference type="OMA" id="RYAQMAY"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="91" mass="10358" checksum="10A4EED0D12FE122" modified="2008-01-15" version="1">MNAAVTNMAVMFGAMQLSKRIPFDDKPEYVRYAQMAYLASQLLCLAVFYFCSLQIKRKNDLTVLKYVNAKNPMVRSTFGFSHALADMFVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5I3</accession>
    <name>A8Q5I3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729795.1">
        <property type="nucleotide sequence ID" value="XM_001729743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5I3"/>
    <dbReference type="STRING" id="425265.A8Q5I3"/>
    <dbReference type="GeneID" id="5854112"/>
    <dbReference type="KEGG" id="mgl:MGL_2781"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2781"/>
    <dbReference type="InParanoid" id="A8Q5I3"/>
    <dbReference type="OMA" id="CINARYL"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="3">
        <location>
            <begin position="61"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="425" mass="46317" checksum="4425900E015DB8EB" modified="2008-01-15" version="1">MNISETLARQIRFIVERAVAPAQTSIYDLLDPSSKSVVLGTPGEDDEYSYLPSWGHESGWKQNFVSTGSSSIDDSLNGGFAKGMISELVGESATGKTQFCLYVTVCTALGLPAENQHPKPSSYLRGGKGKSVALITSKGRTAAQHMVSRMVEIAQQLLRLWFEQPSVPDTHVDELVEKGIKLLLGNVFLACTNTFESAEHVLCYILPGLVSRKMFSLSAFELLVLDSVPPLLQEDVHENILSDSPASQHSVRASRLHALACFLKRLAFGAGDAASMAVIVVNHVHDAFLHDAALIRRALACGELPYGSLDHDAMQSVIQHKASLPLAYTPQAAHFSGLLAYVPYAKHYASSSHSIEADINCLKMAQLGLVWTNCINARFLLAHVRCPNKIQLPARRFRVVFSPTCAQPAPPEVLFTITRKGIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5I9</accession>
    <name>A8Q5I9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729797.1">
        <property type="nucleotide sequence ID" value="XM_001729745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5I9"/>
    <dbReference type="STRING" id="425265.A8Q5I9"/>
    <dbReference type="GeneID" id="5854098"/>
    <dbReference type="KEGG" id="mgl:MGL_2783"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2783"/>
    <dbReference type="InParanoid" id="A8Q5I9"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="289" mass="32078" checksum="0F8AEDB38C036919" modified="2008-01-15" version="1">MAKEEDELARVMELSLKEYNERNTSLATHSLMGSPRKGDEQSDADDDPDLAAAIAASLREQDARQPKEKAVLGTSSASRQGYQRTELEPSLSKTLQTERPLDVHTNDLDNILTFHDTILRHDAPWAKNIATDGIPQPVQNIHDKAAVSRAKLARKLDLGHRRLRELSSLQEKLSEVVKMYDRLLDSRLGERDSLHGTENRPDGANFTYRDPFGTSFPLTNNPDPSAPPAPLSPSFVSSAPLISDSRTSTSTKQQTSSDSMHGEFLIKACEKNPQHLDESNVQEAMLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5N7</accession>
    <name>A8Q5N7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2799</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729813.1">
        <property type="nucleotide sequence ID" value="XM_001729761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5N7"/>
    <dbReference type="STRING" id="425265.A8Q5N7"/>
    <dbReference type="GeneID" id="5854120"/>
    <dbReference type="KEGG" id="mgl:MGL_2799"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2799"/>
    <dbReference type="InParanoid" id="A8Q5N7"/>
    <dbReference type="OMA" id="IERHDIG"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="172" mass="19172" checksum="82DA5DBFFD1DEBF9" modified="2008-01-15" version="1">MLILARRALSTARWLHTGALRTSVPRMNETVREVEQAHKTYFRQKAGDSAGFRRARKPYRLVNLLSMLAICTFAGGVYAYSILMVEQDDFSDLENFRVTPLVNETHAKPDSSLSQPPVSLEADRPIERHDIGTGWKDALRNRFGSLLGRSDSASVSNIPNATTGPLMNKKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q739</accession>
    <name>A8Q739_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM5</name>
        <name evidence="12" type="ORF">MGL_3301</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729757.1">
        <property type="nucleotide sequence ID" value="XM_001729705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q739"/>
    <dbReference type="FunCoup" id="A8Q739">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q739"/>
    <dbReference type="GeneID" id="5854063"/>
    <dbReference type="KEGG" id="mgl:MGL_3301"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3301"/>
    <dbReference type="InParanoid" id="A8Q739"/>
    <dbReference type="OMA" id="NNICTLI"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="87" mass="9476" checksum="DDE726E8C6400CDF" modified="2008-01-15" version="1">MSAAATILPLELVDRCIGSSIWVVMKGQREFVGKLLGFDDYVNMVLEDAVEYEETPDGYKKTHLSKTLLNGNNICTLIPGGQGPESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q789</accession>
    <name>A8Q789_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_3314</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729770.1">
        <property type="nucleotide sequence ID" value="XM_001729718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q789"/>
    <dbReference type="FunCoup" id="A8Q789">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q789"/>
    <dbReference type="GeneID" id="5854076"/>
    <dbReference type="KEGG" id="mgl:MGL_3314"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3314"/>
    <dbReference type="InParanoid" id="A8Q789"/>
    <dbReference type="OMA" id="FIHIPDG"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="15">
        <location>
            <begin position="206"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="16">
        <location>
            <begin position="515"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="17">
        <location>
            <begin position="617"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="709"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP42556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="798" mass="88490" checksum="92A2066E6FCF86F5" modified="2008-01-15" version="1">MSAGQTLVLDPSARLPFVTPLVLSNLAKEHGAETPDLSFEVNAPTSLKKAASSNGADTIQGAVDVLRALASMYANVGLMGANEAESNAVDAYLVQSDALATAPFQAAMQCADDLDQHLALRTYLVGFRVTAADAAIWGAIRSSSPLLGIIKKHAHAHLARWYAHVDALVAFSSAVTMMAEAKSNMFKNKKTAAGFDLFLQGAKEGQVVTRFPPEASGYLHVGHTKAAILNQYFAKAYKGRLIVRFDDTNPSKEKQEFEDAIIEDLALLGIQGDVLTHTSDYFDQLRDLAVRMIKEGHAYADDTPQEQMRAERMDGIPSKRRDASVEENLSHFQAMCDGTDEGRAWCLRAKMSVDNPNKAMRDPVMYRCNADVPHQRTGTKYKAYPTYDFACPVVDSLEGVTHALRTNEYHDRNPQYAWFLSTLGLRNVEIWDYGRMNFVYTLLSKRKLQWFVDHGIVNDWSDPRFPTVRGMRRRGMTIDCIQQFILSQGPSQQIINMEWDNIWALNKRLIDPVVPRFVALAEDKLVKATIAGAPPAHEKQVPKHKKNAELGMKTTVYDGRILIEQADAASFADQEEITLMDWGNVIVRGKTTTPDGVVTNLELEAHFDGDFKSTKKKVTWLAQPSESRHLTPVMLLDFDYLITKKKLEEEDNFMDYLTPQTRFETPALADANVAALKEGDQIQFERNGYYILDKAQGVDGRREFIKIPDGRAASSASKAAPDENPEQKKAAAAAARAQKAAQKEEKKKQKEAKAANGSKPASSSSDPVQQLIDEGTKNINMYAAPLIQQPTDVPVKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8C4</accession>
    <name>A8Q8C4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729701.1">
        <property type="nucleotide sequence ID" value="XM_001729649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8C4"/>
    <dbReference type="STRING" id="425265.A8Q8C4"/>
    <dbReference type="GeneID" id="5854007"/>
    <dbReference type="KEGG" id="mgl:MGL_3245"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3245"/>
    <dbReference type="InParanoid" id="A8Q8C4"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="461" mass="50880" checksum="9263357B89B527AE" modified="2008-01-15" version="1">MDLGTMQKKLRSGQYKTKNQFAHDLNLIWDNCLVYNASPTHPLRRNATFMRRKANHLLEFLSDKHESKDLLAQWQLSSSTTSNMPRVSSDVASTSADILSTSSTGTFNGSGNNNNNNNTNNDKVGAHLEGSGMSIDPTVPLSSHPTPLPQRYALRRTTDSSRVFHELDVNMSKLEEGTHFSHLQPSASTSSTMPTSRSTSLAPTLDVLKQVSPSTPDPLSTALRRPPATAQQRWWSACSSDAMLCAGTPVLRHESYEPPARFLATESEHLTSRLPTQRPGVPRMMARNIRMLQRLYHTHNKLYQLAEAVELDLPIPPSLGEISSSEEEDEQEEMEVDKDVEAETKARADQVVLEEEEHNLHAPHNALKRPEKQRHSDTGPGPANEAIELCVPYASHAPPPRLSASYAHAQASWQVQTLLAHAGFEGTHSAPVPGAGRRRYRVPNGPWSDASSVHGPVCPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8W3</accession>
    <name>A8Q8W3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 8 (cellulase D) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729315.1">
        <property type="nucleotide sequence ID" value="XM_001729263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8W3"/>
    <dbReference type="STRING" id="425265.A8Q8W3"/>
    <dbReference type="GeneID" id="5853613"/>
    <dbReference type="KEGG" id="mgl:MGL_3350"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3350"/>
    <dbReference type="InParanoid" id="A8Q8W3"/>
    <dbReference type="OMA" id="PWRLAHY"/>
    <dbReference type="OrthoDB" id="2541080at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002037">
        <property type="entry name" value="Glyco_hydro_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01270">
        <property type="entry name" value="Glyco_hydro_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00735">
        <property type="entry name" value="GLHYDRLASE8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="360" mass="40220" checksum="E3FFC1B6F0EC7028" modified="2008-01-15" version="1">MEAKYRQWCSTYMRSSPSGLYCFYNGSGDNGDAVTCSEAHGYAMLIAVLHGNQVDFDGLLTFFLNFRNEHGLMMWQVRMNQSGALYVEEDARDCATDGDIDIATALFQAQRVWPNGSSNFPAGAYGYEAAALSDALLAHCVHPELHVPLLGDWCCTDSKENRRLHDSTRSSDFILSSFLLFHMKHPNPESRQRWQQVLEATLQVAISQLDVNPRTGLIADFLVHDKRHGWHPSKGKHLESKYDGEMSWNACRTPWRLAHYYAVSGDQRILPLLQTMLKTLLNANFPAVPAGIRIRDGKGLADYSSRAFIAPVGYLAYALGDGASHMTAIRALDDEEDEYFGDSIDLVIAEEAMAAPMWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8Y0</accession>
    <name>A8Q8Y0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729331.1">
        <property type="nucleotide sequence ID" value="XM_001729279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8Y0"/>
    <dbReference type="FunCoup" id="A8Q8Y0">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8Y0"/>
    <dbReference type="GeneID" id="5853638"/>
    <dbReference type="KEGG" id="mgl:MGL_3366"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3366"/>
    <dbReference type="InParanoid" id="A8Q8Y0"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="142" mass="16235" checksum="8B722616654A1494" modified="2008-01-15" version="1">MVYMERLIGVKQNIPAWVRLLVGVRDRSYALERIQFNPHHPCVHMHTVNLSYSDFIQVKEHISYMPDNGRTRYIQNAHIECPGLTHVAHGVFDSAAARLEEFTLHRFRENAERGRSGFTHVLQAMFGPALAQFAHIATPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q962</accession>
    <name>A8Q962_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate lyase</fullName>
            <ecNumber evidence="5">4.1.3.1</ecNumber>
            <ecNumber evidence="4">4.1.3.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Methylisocitrate lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Threo-D(S)-isocitrate glyoxylate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_3419</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.1" evidence="5"/>
    <dbReference type="EC" id="4.1.3.30" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729384.1">
        <property type="nucleotide sequence ID" value="XM_001729332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q962"/>
    <dbReference type="STRING" id="425265.A8Q962"/>
    <dbReference type="GeneID" id="5853691"/>
    <dbReference type="KEGG" id="mgl:MGL_3419"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3419"/>
    <dbReference type="InParanoid" id="A8Q962"/>
    <dbReference type="OMA" id="VESDWMA"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="298" mass="33249" checksum="DCB252C118704BAD" modified="2008-01-15" version="1">MPYDPKNEDALFQKEVEDVKQWWKSPRFVGVTRPYTAEAVVSKRGTMRQHYLSNEQAKKMWGLLEHHAKNKTTSHTFGALDPVQVSQMAKYLETVYVSGWQSSSTASSTNEPGPDLADYPSNTVPNKVEHLFMAQLFHDRKQQDARRSMTAEQRAKTPYVDYMRPIVADADTGHGGLTAVMKLAKMFVEKGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLIAIRLQYDIMGVENLVVARTDSEAATLITTNVDERDHPFILGTTNRDLQPLVEVMTAAERSGKQGRRPSCGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9F7</accession>
    <name>A8Q9F7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein uL2 RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729438.1">
        <property type="nucleotide sequence ID" value="XM_001729386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9F7"/>
    <dbReference type="STRING" id="425265.A8Q9F7"/>
    <dbReference type="GeneID" id="5853745"/>
    <dbReference type="KEGG" id="mgl:MGL_3473"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3473"/>
    <dbReference type="InParanoid" id="A8Q9F7"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="2">
        <location>
            <begin position="162"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="225" mass="25649" checksum="BC11D4890C07D804" modified="2008-01-15" version="1">MSMPLLRMSLRAPMPMPLRQRAISTARARQAPVQQPIERLGSGAPVAVHTDGTPIMPPLHSLGHAMSTNEQQRTTVPSRRERRGAKKQQRIMTRETRKRNTIAARLGVADKKLSPYVRTDQQFKMFKPITKSIRWLRYPLSPNLHRGRPVRELTIPKRGSGGRNHHGHITVRGRGGGHRRRLRLVDFYRWEPGEQRVVRLEYDPSPQCATISTDPATTRDGSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9M8</accession>
    <name>A8Q9M8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3511</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729476.1">
        <property type="nucleotide sequence ID" value="XM_001729424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9M8"/>
    <dbReference type="FunCoup" id="A8Q9M8">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9M8"/>
    <dbReference type="GeneID" id="5853783"/>
    <dbReference type="KEGG" id="mgl:MGL_3511"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3511"/>
    <dbReference type="InParanoid" id="A8Q9M8"/>
    <dbReference type="OMA" id="QKEHING"/>
    <dbReference type="OrthoDB" id="2532770at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="12">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="103" mass="11396" checksum="48235FCE079DA9BE" modified="2008-01-15" version="1">MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYDETRGVLKLFLESVIRDSVTYTEHAKRKTVTSLDVIYALKRQGRTLYGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9N3</accession>
    <name>A8Q9N3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729481.1">
        <property type="nucleotide sequence ID" value="XM_001729429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9N3"/>
    <dbReference type="FunCoup" id="A8Q9N3">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9N3"/>
    <dbReference type="GeneID" id="5853788"/>
    <dbReference type="KEGG" id="mgl:MGL_3516"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3516"/>
    <dbReference type="InParanoid" id="A8Q9N3"/>
    <dbReference type="OMA" id="KPRGCTG"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="96"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="405"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1121"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1132"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1189"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1232" mass="134893" checksum="F7F011585A204E62" modified="2008-01-15" version="1">MTRSSSPTNTPTHTSCLDTLEEGEGALPTSVLDRFKRARTTSPDTDIGSARSVTPDAEYKSGTAVPTRATDKDDMPGSSAMRSSDECVNALMDESLSLDDARVPHTTLVREVETWRASQPRIGDTWYVIPADWYERWKVKPQGIAAMNLEALCTNDNGNVTARYRPLRQDLVEHADYELVPAQAWDILASRYRIHGPALGRSVVPGQAPGQARIELFPPCIELAVCGESPEVEPFRSAAASIASSTSLLPTVRLSSGVSLRTLKAHVRAMHLCPRHEDAHVRFFRLPPSLKLTALTEHGMLSKQALAKADPPIELVEGTDDATLASLDLTAPSVFLGIDVRVRTASDPRSFTWQVSTTTSDTGTTDALPTSHTSSRTAITPAPAFLPSLAPPAQHGSTARPCGLRGLANLGNTCFMNSALQCLSNTHELQQYFLNGVQMDELNTDNPLGMGGTLAMAYGRLVSALWSESASGAVVPREFKTTLARFAPQFMGYAQQDSQELLAFLLDGLHEDLNRIHKKPYIEAPDWIGGSDADMVRFAQQQWDLYKARNDSVIVDLFQGQYRSTLVCPTCHKVSVKFDPFMYLTLPIPNTRKWRGRVYVVPQHAAQPLVQVDVQLPATATVAELRTKVADLLSMDPACLLMGEVWSYHVYRWLEAFEPVSDISASDYIYLWEVADAFTMPKPMKPTTSRFSFFSRPERTVADIEAAYPPPSDMPATICLPVYSCKADGPDRFGSFRRSLGEPFGLPFFVSIPREKAHDVAWIYAQVLEQYVRFSPEASATDLCAKAADAKRATDARTSADPSTSPDAVPPHTSASVVECAAPPAFPFALRFSVPSADEAMHRGDDANDQTTECMTQRAARLGCPPNSDEASHAAWPVTYPGGALYALWEGAVADAVLEQVRANQTWGPISLAQDADFQKGTAMLAEGKRRAPKLRLDDCLDEFTRAEQLGENDLWYCPACRDFRQATKKFDLWKVPDILVVHLKRFSAGRGTRDKLDNWIEFPLEHLDLRDRVVGTRLWHSLRMERAPSQMQLKEGLIVSHDTHDDDVLADEPVYDLYAVDNHFGGLGGGHYTAFAKNPADGHWYNFDDSCVRPVSDPDMVKSSAAYLLFYRRRTTRPIGSTSRDRLMEKQQQQALATASTAASCTDTASPGRTGPPGSPAPVAPPFLPAATSPSLPVSSAPWPPSPTMSSSSSSSTSSPTSPISSSTDTKVPLNTDETHVAPDLDDDPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9P0</accession>
    <name>A8Q9P0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729488.1">
        <property type="nucleotide sequence ID" value="XM_001729436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9P0"/>
    <dbReference type="FunCoup" id="A8Q9P0">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9P0"/>
    <dbReference type="GeneID" id="5853795"/>
    <dbReference type="KEGG" id="mgl:MGL_3523"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3523"/>
    <dbReference type="InParanoid" id="A8Q9P0"/>
    <dbReference type="OMA" id="GIPFFDH"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000004">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002111">
        <property type="entry name" value="PRK00951.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="202" mass="21989" checksum="9DF5E21515592C7A" modified="2008-01-15" version="1">MSVEIRRASLERNTNETQIQVSIALDTHPEYAPQVIKISTGIGFLDHMLHALAKHGGMSLEIACKGDLWIDDHHTAEDCAIALGVAFKKALGAIRGVKRFGTGHAPLDEALSRAVVDLSSRPYCHTDLQLRREKIGDLSCEMIPHVFHSFATEAGITLHVDVLHGMNDHHKAESAFKATALALKEAITRTGMNDVPSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9Q5</accession>
    <name>A8Q9Q5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729501.1">
        <property type="nucleotide sequence ID" value="XM_001729449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9Q5"/>
    <dbReference type="FunCoup" id="A8Q9Q5">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9Q5"/>
    <dbReference type="GeneID" id="5853808"/>
    <dbReference type="KEGG" id="mgl:MGL_3536"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3536"/>
    <dbReference type="InParanoid" id="A8Q9Q5"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="263"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="307" mass="34116" checksum="269CFEEDF1133BD5" modified="2008-01-15" version="1">MLLEAAFKSSHEFYRVLSEQRTQMERMNAAHQELVNSDPFNVEAQKKIEETIRQERVAENLEHAIEYSPESFGNVSMLYVNLKVNGHPIKAFVDSGAQATIISPDCATRCGIMRLLDTRFAGVALGVGTAKILGRVHSAQIQLGTDLFLPCSFTVLEGKNVDMLFGLDMLKRYQASIDLKKGALIIQDREIPFLAEHEIPKQFPSLNELTDAGKKTIDGDGHDNTEPISYGNMQSAYGHASSQEMSGAKVEVSKNQQNTEKGIFNETGKNQELRDMLNLGIPEQEAEQFLELSNGNLDLAVSLYFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9R2</accession>
    <name>A8Q9R2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729507.1">
        <property type="nucleotide sequence ID" value="XM_001729455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9R2"/>
    <dbReference type="STRING" id="425265.A8Q9R2"/>
    <dbReference type="GeneID" id="5853814"/>
    <dbReference type="KEGG" id="mgl:MGL_3542"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3542"/>
    <dbReference type="InParanoid" id="A8Q9R2"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22329" checksum="E2A3F70A3192548C" modified="2008-01-15" version="1">MIGRGIAFVTYKYEANAQFAKEAMMHQSLDHDEVLNVRWAAEDPRSDGEARDAHERRGLAEKRISEVENTRLALQDDYKELKNSDVDWEEYARAKRQRLNLSEEEKKRLDEENERGWDEYYASKKTISPLTPQNAQALHPSLAKPSLLSDDALQSLHALRNRATIVDRTPSNVNEAPKKTNSVALDGIAAYESDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9S4</accession>
    <name>A8Q9S4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729516.1">
        <property type="nucleotide sequence ID" value="XM_001729464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9S4"/>
    <dbReference type="STRING" id="425265.A8Q9S4"/>
    <dbReference type="GeneID" id="5853823"/>
    <dbReference type="KEGG" id="mgl:MGL_3551"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3551"/>
    <dbReference type="InParanoid" id="A8Q9S4"/>
    <dbReference type="OMA" id="CIRTHAK"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="316" mass="34617" checksum="10C6176148F9A1F3" modified="2008-01-15" version="1">MDSTNPTAEPSRPTPSVDHLGLSQEHHTILSQYANGIMTAELVSAWPTMRPVIKQCIRTHAKAYDTRTLPVLHKAAPLAQMMRESQGTDEPRSAAFDLVMSEHEIQPEDLQDFYPARTPPPSETWPSWDVVLDGQDLERVCEHICAFLDEFDEAPPFTIQRLAELVLDPARYYHTRSKFLGALRRVLCVTGMASVRAQYACAEDDARPSQPGDLPANDSLTATSTTNPSSNESPFRMRTGSDAQLYAPLPFPLPAHDSEPPTSPTKPSSDAKSTGLPAGLVDEFDSSSQHGTVSGTMHPLSATTQADIPEKRPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA39</accession>
    <name>A8QA39_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_3598</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729131.1">
        <property type="nucleotide sequence ID" value="XM_001729079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA39"/>
    <dbReference type="FunCoup" id="A8QA39">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA39"/>
    <dbReference type="MEROPS" id="M41.007"/>
    <dbReference type="GeneID" id="5853437"/>
    <dbReference type="KEGG" id="mgl:MGL_3598"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3598"/>
    <dbReference type="InParanoid" id="A8QA39"/>
    <dbReference type="OMA" id="ARQKGNF"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="378"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="785"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="788"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP41917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="835" mass="91744" checksum="580B391C8A7CEF5A" modified="2008-01-15" version="1">MLAVSSPLVTVRSTPSKVLVPSALLLRTFSSVSRHPTRPSVLFVPRKLKTDSAYPNFVSIRLFATSSGDGPHHDEKKKREFHESIERGLREAKSGKKADDVPDELKHFFGKNNRSPHSDNGPEISKNDADNDESQARNSHPSDQNKKSSNKGGNKNNNNNEMRANMNMIIATIISTYLLYRFTSPEASTREITWQEFRSAFLDKGLVDRLVVVNRAKVNVYLHNSATDSLYPHQAGSSMLGAPQYWFSVGSVEAFERHLEEAQRELGIPSNERIPVAYHESISMASTLLHFAPTLILAGLLFYLTRRATGGGMGGGSGGGPGGIFGIGKSRAKLFNQETDVKVKFENVAGMDEAKQEIMEFVSFLKNPERYERLGAKIPRGAILSGPPGTGKTLVAKATAGEAGVPFLSVSGSEFVEMFVGVGPSRVRDMFATAKKMAPCIIFVDEIDAIGKSRGKGGNFGGNDERESTLNELLVQMDGFGTNEHVVVLAGTNRPDVLDPALLRPGRFDRHIAIDRPDISGRRAIFHVHLKPLKLSAKVNEDLLAEKLSTLTPGFSGADVANVCNEAALIAARAEAPAVEETHFELAIERVIAGLERKSRVLSPEEKTTVAYHEAGHAVCGWFLEFADPLLKVSIIPRGVGALGYAQYLPKERYLFSTEQLSDRMCMMLGGRVSEEIFFGRITTGAQDDLSKITRLAFEICASYGMNTKLGPISYRTDQESMHKPYSERTGELLDEQVRAMVLQVHERTTNLLTDHKADVEKVAKLLLEREVITREDMTNLLGKRPFKQADEADEYLDKKGRLSGHGEASAPPPPHDEVNPDPNVTTSESRIPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA75</accession>
    <name>A8QA75_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bola-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729167.1">
        <property type="nucleotide sequence ID" value="XM_001729115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA75"/>
    <dbReference type="STRING" id="425265.A8QA75"/>
    <dbReference type="GeneID" id="5853473"/>
    <dbReference type="KEGG" id="mgl:MGL_3634"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3634"/>
    <dbReference type="InParanoid" id="A8QA75"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="27976" checksum="DE17FD67CA7B7D84" modified="2008-01-15" version="1">MVSQTELEHAIHEKVGQVDTLFVSDVSGGCGQAYDIVIVSDQFDGKSTLQRHRLVNDRLKNEIASMHAFSQKTYTTKQFGELKSKYSQQPPTSSPSPSPSLTSTATGSEAVVTPQHAQPAQKNTSPTSIDAVSTKAFPNAKESASARVTRVEIPPRTSDSISVPELTLTPVSESKSRFGPFSPQTEPQLRSPSSSTFDLHQPPSTLENVNISRLHHANITNPQFWLRLRELLQSEFMQESTAAGGDVMAIDVRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAA0</accession>
    <name>A8QAA0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729192.1">
        <property type="nucleotide sequence ID" value="XM_001729140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAA0"/>
    <dbReference type="STRING" id="425265.A8QAA0"/>
    <dbReference type="GeneID" id="5853498"/>
    <dbReference type="KEGG" id="mgl:MGL_3659"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3659"/>
    <dbReference type="InParanoid" id="A8QAA0"/>
    <dbReference type="OMA" id="CKFFRNN"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="3">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="3">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="530"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="691" mass="74524" checksum="84FC23A9C1D8AD07" modified="2008-01-15" version="1">MWTHRRPLHTLIMSVNELFALDKRVSEFRDLQNLDVQSNQLTSLPSSFSQLQNLTSLNLARNALSRVPSCILALTSLVSLDLSDNMLDTLWSQADAEKAGIAASDVLRSLATLNLAYNCLSTSALVPMPASLKRLQLSHNLLREPLPIDICGSAVHLEELVLSGNDLPDAVFAHDGTSYAFPHLHVLDVRKTHVSSLSALESLFASAPSLNVSEAKDKNRAPVHAPRLEGAPVCTPHQLVRVANIPTHPDKQHDPVWIATHDNTLLPPLYILSDVQGRSESSHRRRRGGRGRGGEDRARTARDERDENGHAPPNAGSALANAKLSTKKKEALGQVPCKFFRNNGCSAGEACPFAHTMPGEGQPKAVCQWYIKGSCRFGHRCALAHILPGQPMSMDRKNKRSAQQSASSNAAAGAGAGGQASSSSQMPTAPAPSSNHTDEQSRPDDKQSTSLLAAHLQPPLAPTTSAPIPPSSSSAMLIPNRNHKMRRDGPAASALTLSKDLEPSSLSLHAGWHSDSSRVRSQESTGATGFGSSPFSHPGSHGLFFNANSDARTSQDATASPWRTTSMTLPDTKSDDLLADAGHAEDFLPSSLSDLLTPAELERRTRSSRDAATTSLLPLGIRFGIPELASGYGIYEFRVRYLIARACAIIGKQQPPVIYEWDRSPSTSRHTQYARVAVYAAYTGPRFKLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAG2</accession>
    <name>A8QAG2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIID subunit 8 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729254.1">
        <property type="nucleotide sequence ID" value="XM_001729202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAG2"/>
    <dbReference type="STRING" id="425265.A8QAG2"/>
    <dbReference type="GeneID" id="5853560"/>
    <dbReference type="KEGG" id="mgl:MGL_3721"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3721"/>
    <dbReference type="InParanoid" id="A8QAG2"/>
    <dbReference type="OMA" id="PRAVNYK"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="2">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="262" mass="29544" checksum="2CDF0AAE47AB8FE7" modified="2008-01-15" version="1">MIDTFEGLGLSLTELGAFSETVRRHEEGAKRYHIQVGRPKRGHENWENPSASFLPSDDQNETDNNNASSSTWATLMHDIVPDHLPPEPPRHCWMFTPVYATEVLSDMPALQLVNRKLDNARLVESSLRKLIKHTDSATPLKPWVSQQAPKLTEDGVLSSQKACAMNDADQSSMSVDEPMTVSELESSSREPLTTESMRHWGNKERHDSARHALPRAVNYKAAWYASFTSTDSKLPTSNLYTARLRGNMDESSRRPRRFVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAM4</accession>
    <name>A8QAM4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728995.1">
        <property type="nucleotide sequence ID" value="XM_001728943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAM4"/>
    <dbReference type="STRING" id="425265.A8QAM4"/>
    <dbReference type="GeneID" id="5853302"/>
    <dbReference type="KEGG" id="mgl:MGL_3783"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3783"/>
    <dbReference type="InParanoid" id="A8QAM4"/>
    <dbReference type="OMA" id="FRGTHRR"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="387" mass="42218" checksum="13F979B10E6950BF" modified="2008-01-15" version="1">MGSTLPAPDDVHRVTGPVQTQTASEALMDHLSSTLPLFSAPSESLQSEWSDTSPNLADSLLSMDFDSTSTLGTSLYQSEIPSDSSLSPLATPKDAVGSRLFAPVDAVVLPTTDAFCHWPDSDALSEPNSKRARLNEPCCLPDSIIKQDFTLFPDDDEQQSRRQVPSSLQTSLVTGDESASVLNLLDSLNSSVCDASPFLSPEPTSTSALSKVFSPNTHPPASLTQTANKSPIPEIAGTEGITSRSSATTLVPASADLADAVKSFRGTHRRRRDAHELLPLNAPVQPRTYHTESATSRRDSKEQSSVSPAEPPLISDGSSPRPEMDARSMKRLSNTIAARRSRHRKAEELKRLYETIEELESQVQQWKERCNKAEMERDRLRRVEPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAN1</accession>
    <name>A8QAN1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729002.1">
        <property type="nucleotide sequence ID" value="XM_001728950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAN1"/>
    <dbReference type="GeneID" id="5853309"/>
    <dbReference type="KEGG" id="mgl:MGL_3790"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3790"/>
    <dbReference type="InParanoid" id="A8QAN1"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="89" mass="10212" checksum="747A1AE496BDC1F7" modified="2008-01-15" version="1">MMRFSGIHYDVVVARSLSGLITAFDPRSYNTCYAVSEKLVHWLREQRYAVDTHSFMLQCNECGTMVEGEHQALEHTKRTLHASYGEKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAU6</accession>
    <name>A8QAU6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZN622/Rei1/Reh1 zinc finger C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729045.1">
        <property type="nucleotide sequence ID" value="XM_001728993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAU6"/>
    <dbReference type="FunCoup" id="A8QAU6">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAU6"/>
    <dbReference type="GeneID" id="5853352"/>
    <dbReference type="KEGG" id="mgl:MGL_3833"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3833"/>
    <dbReference type="InParanoid" id="A8QAU6"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZN622/Rei1/Reh1 zinc finger C2H2-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="267" mass="30499" checksum="B0D39573239A76F5" modified="2008-01-15" version="1">MRAAHGFFVPERKYLVDLVGLLRYLADKVSVGNVCLWCNERGRTFHDLGAVQKHMIDKSHCKVAYDTQEDQLELSDFYDFRSSYADYKPKNKRADEWEDVSDDANDGQGALKDEGETVWEDLTDEDDDDDDDENDGSIPPQDNGVRYGDSEYELVLPSGARLGHRSMQRYYRQSLWQTPAGHARETASPANGRALAHRIAGETGGMPNSLVVPSRGGHELVARNRGEAKEATRHVREFRDVKRREQFKTKVGFRNNHQKHYRDALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAU8</accession>
    <name>A8QAU8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729046.1">
        <property type="nucleotide sequence ID" value="XM_001728994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAU8"/>
    <dbReference type="STRING" id="425265.A8QAU8"/>
    <dbReference type="GeneID" id="5853353"/>
    <dbReference type="KEGG" id="mgl:MGL_3834"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3834"/>
    <dbReference type="InParanoid" id="A8QAU8"/>
    <dbReference type="OMA" id="WGDDQIE"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="59911" checksum="108AE127592C310E" modified="2008-01-15" version="1">MSSVDAGGPTAADSEAACAAIIRVLPTDPSELARFFHSHPHTEHVLSWLLFTLASRVLDATPLTDGTGADVLDVLLRLCAHGDRALLQRVCGRGHLWDVCVLASVYDGVDVRPIMTALWPHSNLAKWTIDLATSSILHEIDNFAFLPWAHALRHMRRAIRLTYSLLAVLGGGSSSRGSDRVATAACHINVDCASSLANLAQALATAYNDVLAARRIPSDEVSSSATPWPTAWLATKVDILAASDACVLLTPKESSGLVLERLDTLAKEVPDAVALVDASLLADLQSAAPTCASIVGASPTPFPGAAWAAVRSVLRVPRVNPALVDAVVDVLSYMDRPSVERRLRRPRYKNMSAEAIIEAFLDDPDGLQDIEADHEPDLPPPPSKSTSSHSASSDAPLPPDVKAAIIARAESQDAFQEEWDLDAPSTPAQHAERILLQTYQMDASVFARTKAARASSARAHLRDALAHLGSWGDDQIEGWGVMFDRDPRRHERLTRVKSIVAPNVNVGTERSWAPDKLKGGRTPKPTSGPSASQRGGRGGRGGRGGRGGSGSSRGSGRGGRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB00</accession>
    <name>A8QB00_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">XPA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729073.1">
        <property type="nucleotide sequence ID" value="XM_001729021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB00"/>
    <dbReference type="FunCoup" id="A8QB00">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QB00"/>
    <dbReference type="GeneID" id="5853380"/>
    <dbReference type="KEGG" id="mgl:MGL_3861"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3861"/>
    <dbReference type="InParanoid" id="A8QB00"/>
    <dbReference type="OMA" id="MERHEHE"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="5">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="306" mass="35259" checksum="B59B936581E26495" modified="2008-01-15" version="1">MSDKDASADHVQANRMLARKRLRAMAAQRDHAGPSSVRDASTQRSHHTPPALSGPGSGPGSQALPRDKALGDYIEFDLTRLHNSKGGFLVQEHDGKDAILALEEQRKEREREKQRLRDQMEPGVSLDPTTRPVCEMCGSSDIMYEPFLRVFNVCVCRSCEREHAERYSLLTKTEVKEDYLLTDAELADAELLPHLLKKNPHKSTYSNMMLFLRGQVEAYAFSDAKWKSAEGLDAEYQRRNDEKARKRTRKFQQSLDRLRKRTIRDNIWQQRRDAQHVHDWQPLRSSMPTNQQQCRSCGQRVTVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBQ9</accession>
    <name>A8QBQ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728939.1">
        <property type="nucleotide sequence ID" value="XM_001728887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBQ9"/>
    <dbReference type="STRING" id="425265.A8QBQ9"/>
    <dbReference type="GeneID" id="5853245"/>
    <dbReference type="KEGG" id="mgl:MGL_3933"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3933"/>
    <dbReference type="InParanoid" id="A8QBQ9"/>
    <dbReference type="OMA" id="GPSEHYA"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="294" mass="32915" checksum="6D5B21AF941B8D45" modified="2008-01-15" version="1">MDDDLSLRHVQMLVIDEADTLLDEGFRTLTQKILRETPGESAHVFVTATIPRSMRMYLDDAYPSLVTLASPHLHHLPQRLSVMFVDPGGNKDLAVVKELFRVFTTPGCEKDQVLIFRDKRSGVESLSRFLHARNVDHVAWTGAAEDRKTRTSQHVAPFLAGPSEHYARRHHRDVETPRVLVTTSLLSRGLDFGPHLRHVFLPDAGRNTTRSVHAANNNALELLHRAGRSARAGRAGTVVVFDKNSAPGKTKVLLNRRGQKKGIVRGQMDLLVRALQRPSKSSRRRQRASPKSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCD0</accession>
    <name>A8QCD0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Erythromycin biosynthesis protein CIII-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728828.1">
        <property type="nucleotide sequence ID" value="XM_001728776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCD0"/>
    <dbReference type="GeneID" id="5853134"/>
    <dbReference type="KEGG" id="mgl:MGL_3995"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3995"/>
    <dbReference type="InParanoid" id="A8QCD0"/>
    <dbReference type="OMA" id="IHFNTPG"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF151">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="421"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="564" mass="63007" checksum="312ECBA9C223076F" modified="2008-01-15" version="1">MSFVLSPKRYLILTNPATGQVNPLLSLAEELVNRGNQVVFSSSAPILKKIQKMQSRMGLLVQPESIPSPEFLMRVPLTFYSLGESDVVSDYTNKAFEMTDRFHDLCRSKPGQIWGWLSTFIENVPGASDTYRDVVVMIRDLIESLNPDLIIVDNFSPFAVDGVRLTKRPFVATSPAAASAVASNVDILRSPMPMSGGRSAHGGILMLIHNLVFIVIWLHFIYFNQWPIQRRRFRRNVLGLKPTDTICDSVMTPTPGMLPQQIATISFNVANMDVYPPEAYHNSVYFVGPCFAPKQLLMPSARSIPSSPVSLSFRSMDLSPSVSTATTPVVADGFLEKQMLSAHAVAQMQDPVKIWMDRAMTENKRILYINMGSIFFYSLEDYNNILHALEILHREVPDVLVLWKVSNHPKNVQPIPTVEEANLPSYIRREHWIPDVEVVLSHPSLAASMHHGGGNSYNEALAHGVPQFCVSQWVDTHDIGLYITHSGIGLWADQSPKFDPTDISTKLVRLLQTDYKTFRHAALSWKLKCIQAGGTAGAVEIIENLLRSYDFVNNDSKAPFPDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8QEE4</accession>
    <name>A8QEE4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000033">
        <property type="protein sequence ID" value="EDP41380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728594.1">
        <property type="nucleotide sequence ID" value="XM_001728542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QEE4"/>
    <dbReference type="GeneID" id="5852902"/>
    <dbReference type="KEGG" id="mgl:MGL_4266"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4266"/>
    <dbReference type="InParanoid" id="A8QEE4"/>
    <dbReference type="OMA" id="TEIGWGT"/>
    <dbReference type="OrthoDB" id="3338260at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728104" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23223" checksum="E8968165CA8438B4" modified="2008-01-15" version="1">MKVFSIAALSTLSIASVWAGMDCEKTSRPMSLQYTEIGWGTRYSNHTGLAKKGSDSHAFLRIQDGASREQFEFFECKSPPEGFETSPADAKYGQIRSAKDHSLCLTVQGIDNRPVYDYNHKAKGTKREYDRKNGYLTLEACSSHPRRQWWSDSISYVGMKKDQKRNHCSVDDDGKLFMYRNHAPSMMPHGGDSLGGFLTWESKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A8QET8</accession>
    <name>A8QET8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_4283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000049">
        <property type="protein sequence ID" value="EDP41362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="mgl:MGL_4283"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4283"/>
    <dbReference type="InParanoid" id="A8QET8"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="14" mass="1552" checksum="73840E271878F95B" modified="2008-01-15" version="1">MAGYTTEIVKARIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQY5</accession>
    <name>A8PQY5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732766.1">
        <property type="nucleotide sequence ID" value="XM_001732714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQY5"/>
    <dbReference type="STRING" id="425265.A8PQY5"/>
    <dbReference type="GeneID" id="5857072"/>
    <dbReference type="KEGG" id="mgl:MGL_0541"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0541"/>
    <dbReference type="InParanoid" id="A8PQY5"/>
    <dbReference type="OMA" id="IKVENTM"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="223" mass="25378" checksum="48F6EF095849F27A" modified="2008-01-15" version="1">MLMVGCPGSGKGTLSARIEKHFGVHFITAGDLLRWHIRHGTELGKQASESIRAGRLMPDATMMQLVAEKLHDMRETHWILDGFPRTEGQAQLLSEELYAAHCPLSLVVNLKVPESAILQRILQRWTHMPSGRVYNLSFNPPKTPGLDDLTGEPLEKREDDNPDTFKKRIDAFHTQTEPMIQHFRALRSPYDESLPLLVDMAGSTSNEIWPKLHQLIRERFPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQY9</accession>
    <name>A8PQY9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mif2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732770.1">
        <property type="nucleotide sequence ID" value="XM_001732718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQY9"/>
    <dbReference type="STRING" id="425265.A8PQY9"/>
    <dbReference type="GeneID" id="5857076"/>
    <dbReference type="KEGG" id="mgl:MGL_0545"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0545"/>
    <dbReference type="InParanoid" id="A8PQY9"/>
    <dbReference type="OMA" id="TMRIACT"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="531"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="71287" checksum="5A6FC437D1038166" modified="2008-01-15" version="1">MSVAPARRFHEEGLGSRTGLRIGNIRRDDRGNEDLDAFFAESKRVLEWMEASDDEAASESAPSTADQIDQIPEPDDNGWDRRISRVSEWAARSLSSVPRASPVSMLTIQGDTNNSHALTPSQEYTQRIQPRSSMAPRAEETMWESTVDISRSDRTFRLSAFAGDASTFTSSSSTPASTHGSAWSHQSSFERELHLQRTSQPPAPLASQALTRTQESPHIQPVTWHNDVTLPSASTPLVSSLPARYSMSRGSSTAADMSRIPDTDMPSFLRPDASILSGQSQRRRPSHLLPSSSSSVPLSPASSHHADAAHPSSWDVASQVSASIPELDAMHDVPDDFGTKQDAGQEFAQNYFDLGYGTVGTDLDAQLSSNLDAPLNTLEPVDNIPNGGIIDDVVERGVDRNDNVPVQPILPKKRGRGRPRKDESMPPPRGRPGRPPGRQKPAQKIVERIYDPPSWQLENPDGLRRGKRHRIAPLDWWRGERALYGKPDEPAEQEEGPEGLVAPVLKKVIRVPRAPGEGTFSGMRRFRAKPAGYAHPGRPVGSKNFVPRLTPVDESENETGVDDEDTRLIVRNPEDGWDDNTDPYGRVVDADLNAEVTMRIACTAAGIRPRPAFNQQFSYEKIFGISDFMAAGVLVIPRGGRKTYQAEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR35</accession>
    <name>A8PR35_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732816.1">
        <property type="nucleotide sequence ID" value="XM_001732764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR35"/>
    <dbReference type="STRING" id="425265.A8PR35"/>
    <dbReference type="GeneID" id="5857122"/>
    <dbReference type="KEGG" id="mgl:MGL_0591"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0591"/>
    <dbReference type="InParanoid" id="A8PR35"/>
    <dbReference type="OMA" id="WHTHEPL"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="563" mass="61855" checksum="442EE92C8FADDC6D" modified="2008-01-15" version="1">MYPVEVAYTTELVRDLVQACIDAVWAWHTHEPLSGDMLVFVPGRDDIQRILQALADRMMEAASTHPSSHRLHLLPLYAELDVNAQRAVFLPPPRGTRKVIVATNVAETSVTLDGVRFVVDSGYTKIRLLDTSTGVDVLAVVPTSRASAQQRAGRAGRTAPGKCLRLYPESELARMRASDAPELVRCDLSMYLLQLKALGIDNVARFDYVPPAPPAAHVARALAYLASLQALDAQGRLCSLGEQLAEAPLSPMMARAVLHAAQEGCADEMLTIAAMTSVGTPFLKIEYGAAMDVHAELARRKFVAEEGDQLTLLNVYEAFIDPRIGRASAAWAAKHALHYATLKRAQAIRAHLVKYATLHWSLPLHRAYDATRLRRCLAAGFFKNAARYMPDGTYRSVQGATLHVHPASVLFSRTPTSTWVVFGDVVWTTQAQMRDIATVEEDWLLSLAYVSMHHDACASLLTHRKDPIFTRMAPKARTPVVALAMVMAIALLASRWIARTFCHFVDACTDMCCATEALCKKLAQYTEPFRACGVLPGKTASGHRQNVGAFACSNRVDRVERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR51</accession>
    <name>A8PR51_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732830.1">
        <property type="nucleotide sequence ID" value="XM_001732778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR51"/>
    <dbReference type="FunCoup" id="A8PR51">
        <property type="interactions" value="647"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR51"/>
    <dbReference type="GeneID" id="5857136"/>
    <dbReference type="KEGG" id="mgl:MGL_0605"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0605"/>
    <dbReference type="InParanoid" id="A8PR51"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="299" mass="33394" checksum="6DF4D8F993CE0214" modified="2008-01-15" version="1">MSKHHLGKECKICGRPYTVFRWNPGNGMRFKHTEICTTCAKLRHVCQSCILDLDYHLPAQVRDAALGSSVKIPMSDINRQYFVNRMDSLLDGASPEATRELVGPSRAGHEVLKKLVHARSDSPWQQQQYLRHHDRPPVCSFYARGACTRGQACPYRHEGAQHAASTHTITNSSTRSESQRPSRSASSMPLIEKVPGAKALDTPSDAHIRTLFFANLPVDMDHKTSFAPSCSQAYRNLTSANAIAHIQMIMSSHCAFVHFETRDNAECARRRFSYQSLHARATPSARCMGPATTLICFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRB9</accession>
    <name>A8PRB9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732242.1">
        <property type="nucleotide sequence ID" value="XM_001732190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRB9"/>
    <dbReference type="STRING" id="425265.A8PRB9"/>
    <dbReference type="GeneID" id="5856548"/>
    <dbReference type="KEGG" id="mgl:MGL_0017"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0017"/>
    <dbReference type="InParanoid" id="A8PRB9"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="289" mass="32387" checksum="BBFC68FBF544271F" modified="2008-01-15" version="1">MSDDGVSLAWNAVVHAGEVLERLKDAMFIVEELRQSHADIWDAHTDASPGRLLLALDDARDRLVHARDRAEDAANMPVASQESSQLSRTRASLHSEFVRVHADALDLELRLESDRALLVLYDACLQFERHMNHLEAAVGRNSDTPDAKSTLQAKKQHIIPACERLLVTIRSSRSISSQLPVQARLDCIESRWASLRQQCDNVDVNETAERMNANLSVSPPSGKRRAIEQEDTRKRRWSLGTPSRLPRTPVNKIGSRIPGSIQRIRCNEQGLCRFAPHVCRGAAMDRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRD6</accession>
    <name>A8PRD6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732253.1">
        <property type="nucleotide sequence ID" value="XM_001732201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRD6"/>
    <dbReference type="STRING" id="425265.A8PRD6"/>
    <dbReference type="GeneID" id="5856559"/>
    <dbReference type="KEGG" id="mgl:MGL_0028"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0028"/>
    <dbReference type="InParanoid" id="A8PRD6"/>
    <dbReference type="OMA" id="TISSHYF"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12374">
        <property type="entry name" value="RRM_UHM_SPF45_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="198"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="357" mass="39660" checksum="FBE0A35139F12FEF" modified="2008-01-15" version="1">MKPDLPKVDRVVPMYLSSYEHKKDVDLAQMAEEDLGESITCAPYHGPTQDHEHIHSMAALRGKKSAPAAPSSLKTVNYCAEYHPFMPNEYTSFCDSLKEWRRLQHYDESSSESEDGVPRRPQYAPPTSYQFRSTESDQGTQSQSVKRCSIFSKCGSPPGPPPLPPLSVLRKKSTSPIDNEMQDTKRASELLSCDVPDTASFAERIMAKYGYKKGQGLGPEGNKGIAAPLEATCIGGKGRGLVVNPNVDPSGDNSYVQFGDPSEIVVLEYFDPCQIKLSDLRQDVEEECNRYGFIQNIIIYPHDDNGLLRVFVQFTGAAGAYRAVRALDSRFVAGRSIRCRYYPAEAYFSGQFVALQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRF1</accession>
    <name>A8PRF1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732263.1">
        <property type="nucleotide sequence ID" value="XM_001732211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRF1"/>
    <dbReference type="STRING" id="425265.A8PRF1"/>
    <dbReference type="GeneID" id="5856569"/>
    <dbReference type="KEGG" id="mgl:MGL_0038"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0038"/>
    <dbReference type="InParanoid" id="A8PRF1"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="45" mass="5260" checksum="738B385B163F420F" modified="2008-01-15" version="1">MDAYYCAECTRLEKDRDGCPKAINLGHTRMDAMFNQKMQNTFQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRI3</accession>
    <name>A8PRI3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732284.1">
        <property type="nucleotide sequence ID" value="XM_001732232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRI3"/>
    <dbReference type="STRING" id="425265.A8PRI3"/>
    <dbReference type="GeneID" id="5856590"/>
    <dbReference type="KEGG" id="mgl:MGL_0059"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0059"/>
    <dbReference type="InParanoid" id="A8PRI3"/>
    <dbReference type="OMA" id="RRHIYRH"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="247" mass="28538" checksum="EAC13E14D8DD72FD" modified="2008-01-15" version="1">MHASCFACILEWIHTKQGDKQCPLCKAPLGSYILHSLDPATHDFHFYSIHHGSETQPFVRAHGVSDDATNASNTNYPVDEIESHTNLTMAREHRTRRTSVSELRRHEEQKTRAKQRAALAFRRHVYRHHLPAKHVASNKYTRYQPYPGPSGFRAKPVYARLLSAFLQRELQVWPHLDIGFLSYYIPALLSHLDVTSDAFLERLTEWIGNERDARLLAHEMELFIRSGRGGLGLDHYDTNPWLQYDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRM2</accession>
    <name>A8PRM2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732309.1">
        <property type="nucleotide sequence ID" value="XM_001732257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRM2"/>
    <dbReference type="GeneID" id="5856615"/>
    <dbReference type="KEGG" id="mgl:MGL_0084"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0084"/>
    <dbReference type="InParanoid" id="A8PRM2"/>
    <dbReference type="OMA" id="WVDEDCM"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="482"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="728" mass="80341" checksum="6F69BC709912A7C4" modified="2008-01-15" version="1">MPQATPFHACYEALLAGERPWEADESPTAAGQRASEKANAAPRAQYMLELLSKPVEHSVIVDLLANVSPNEMMDDRYARRRDNITGLWKEALRVWTESSNLHDELVCHAIDTILALACALLPKAYTNYTLDVITLLAGRMDEADDMFYALMTAIERTCRRPQIDTHNSDDVFAHAPSPPSSSAVIAHQQHSALRLVIVLTACTGSTSLTTYLLHRDLFAAAMHVAQTTSASNEHVLCDVALCTALLATAGHAHGTTHATGLGRDPVSSAFMNHVAFQPYQRRMRDYAHLHDLKRIAHACSARAMHILAAYTHDEHAATHQSRSRMWGLDWMYMDSRKNLLSATTALSPTASAAASATAPTRPPPHAWLFFALWVWVHSNTRFHACVVDAESQGGEPPLIVSFLSVTSFLLTHAAICARATMYAHTALQIMLVLLGRTDAQAPMQAVTKRLLLDEDSLESPAARWCWQVVQCRDKPGALPPMPKTGTKRPRRLATCCVNNVAIFLKYNRSKHLDAASFRTALMAIQRIVLLCAQNKLLLEYDWLEAWRAILATADFIAARQTEISDDTHQLAECLIETMAVVLVYSDKFLQTPAETHWLLYELARSKHTIEKLIPITSTSSTARQVHGVLLREILDAIDADMAKEHDRARSARSWLFFQRNSANEPVSMHTILSIIQHLDLPTLLASDKPACAAVARAALTASSGRSPGGVPSPSASLLRTVQHDWLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRP3</accession>
    <name>A8PRP3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Surfeit locus protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732322.1">
        <property type="nucleotide sequence ID" value="XM_001732270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRP3"/>
    <dbReference type="FunCoup" id="A8PRP3">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRP3"/>
    <dbReference type="GeneID" id="5856628"/>
    <dbReference type="KEGG" id="mgl:MGL_0097"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0097"/>
    <dbReference type="InParanoid" id="A8PRP3"/>
    <dbReference type="OMA" id="RHRHFPW"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21762" checksum="52DD45BD79F306CB" modified="2008-01-15" version="1">MIISSSLVIVRRMPEVSIGSLLFVIVIQGFGYGLITDFNFFLRNLSVIGGLLMVFSDSLAHKRKNLFAGLPSLSETDRKIYFQLAGRVLLIFLFFGFVLQGEWTTLRVVVSILGFGACIMVAIGFKARWSAMFLVLLLSVLNIAVNNFWTVHSAHPQRDFLRYDFFQTLSIVGGLLLLVSLGPGGFSMDERKKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRS1</accession>
    <name>A8PRS1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732340.1">
        <property type="nucleotide sequence ID" value="XM_001732288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRS1"/>
    <dbReference type="STRING" id="425265.A8PRS1"/>
    <dbReference type="GeneID" id="5856646"/>
    <dbReference type="KEGG" id="mgl:MGL_0115"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0115"/>
    <dbReference type="InParanoid" id="A8PRS1"/>
    <dbReference type="OMA" id="HRAFMSK"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="83" mass="9993" checksum="FA25293E9F2E4CD0" modified="2008-01-15" version="1">MLPRGNPLRLRSIALFKELHRLGRDYPDPNYHFIPKLRSAFRKNANLTDPEQIQKLHGLAEFVKKALYMLKKYRALRRRYVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS87</accession>
    <name>A8PS87_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_0213</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732438.1">
        <property type="nucleotide sequence ID" value="XM_001732386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS87"/>
    <dbReference type="FunCoup" id="A8PS87">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS87"/>
    <dbReference type="GeneID" id="5856744"/>
    <dbReference type="KEGG" id="mgl:MGL_0213"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0213"/>
    <dbReference type="InParanoid" id="A8PS87"/>
    <dbReference type="OMA" id="FFAYMYF"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP45224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="536" mass="60466" checksum="C354FD535C5A751F" modified="2008-01-15" version="1">MTRSKTRSAAQGRSMREADVTSLPVPAAERELPAIPDETNNTLHGRKNAGEGTLGAGRTMTLTGDLYANAHSNDDAGVIGRTIPITTTQSPNSAVNTATTYNKHPDQAMRTSGQKSVAMQEPGCNADRKAYWKKIQERVVFSLLMIAGFMFILVMGPSYMILLVLVLETLVYREVTALFNVPGHTILSQQVQNEVEDDDEGESQRERQAEELWSKSLSWYFFAVCNFFLYGETLVYYFKHVVMTDSLFLHFARHHRFISFMLYMFGFMAFVSNLKRRNLKHQFALFCWVHMSLMLIVLSSHFLVDNILEGIIWFWVPSSLVICNDVFAYVCGMMFGRTPLISLSPKKTVEGFIGALLITLAFSWFWAGFFQQFDYMVCPAMSLGMSMFNPPDCEVNSVFLVRTTALPSWIADILSHLVGRSITTFSWTPFQCHALVMAAFASLVAPFGGFFASGFKRAFKIKDFGHSIPGHGGLTDRFDCQFLMGLFSYVYYSSLIRDSRMSVQLVMQIITTQLPIADQKQLLQHLSSYLVDQGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS93</accession>
    <name>A8PS93_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732441.1">
        <property type="nucleotide sequence ID" value="XM_001732389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS93"/>
    <dbReference type="FunCoup" id="A8PS93">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="GeneID" id="5856747"/>
    <dbReference type="KEGG" id="mgl:MGL_0216"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0216"/>
    <dbReference type="InParanoid" id="A8PS93"/>
    <dbReference type="OMA" id="CWFISIS"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="86"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="590" mass="63072" checksum="EBED0AF70D60EBFA" modified="2008-01-15" version="1">MTATSSERTPLLDTPHYQQQNYTQTNTADDEALLAQESAFSAVCGATHGVDPNSSSFMPPGDLSQLNVHGQNTSAPTHSLSELLLIMGAMWVGTFLAALDGTIVATILSTVGSEFQVSKTVGWLGTSYLLTQTAFQPLYGRLSDIFGRRTATLFASSVFLVGSLLCGLSRTFTQLCVARAIAGIGGGGLTSMATIVTSDLVSLKARGTWQGLGNLVFATGAALGGPLGGALADGGIGWRWAFLLQVPLCVVHFTVVSIKVNIPAGPGSMMEKLRRVDVWGALSLVLAVTALLIGLNLGGNELPWLHPLVLLSLLVACVLLCLFVYVEAHVAREPLMPMSVLFRRTPGFVSLACWFISISQFGILFNVPLYFIAIKNTSVASAGMHLIPNAIAASFCSLGSGIIMGRSGKYRHIMLLGGLCAVVGPLMMCFWNGRTTSKFTYWITMPWGGAGFGSTLTITLVALIASVDPRDMAPATGVTYLFRAVGSVLGISLSNSLLQNALKYHLRKASIPSEIIEAIREDVGTLTQLTGKLHKRALWAYENSMHAVFVWILLTAGMSFVCQFFIEEKPLPGHAPPKHVSSRRRENAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSH8</accession>
    <name>A8PSH8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732485.1">
        <property type="nucleotide sequence ID" value="XM_001732433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSH8"/>
    <dbReference type="FunCoup" id="A8PSH8">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSH8"/>
    <dbReference type="GeneID" id="5856791"/>
    <dbReference type="KEGG" id="mgl:MGL_0260"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0260"/>
    <dbReference type="InParanoid" id="A8PSH8"/>
    <dbReference type="OMA" id="HIDFWND"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="109"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="467"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="596" mass="69043" checksum="1A060DB071CBC3A8" modified="2008-01-15" version="1">MTQGSTTGSSSSRRIQNGGRDEHELPSAKRARTDEVLSESCDTGAGEKFRWKKKEVQEQRAGLSREEAERRDAERRAEAEREVERLAARREQRERARQQREEEELLRARQAEASVMADWVAKEDEFVLEQNKARAVIRVRDHRARPIDWFVVQLLWTEVPTPVSADEENSDDEGDELDDTLDIHMDEPVAFIRSLLPGELRELHSDVLTLVRLDKDAKRAAYWKDVLLVCDEQLRHCDAVQNDAQPERIDASIVADVDAMLADKSADQLLDLQTSVRAKLRSGEPLDVEYWEAMLKRIVVWRSAAKLRALHATVTQNRIAKLRLQQRREARRQQAFVAEQAHMQMHTHKGLEDVWDANEMEPAGRDISELLYEEQHLPRYTLEALRDKLRDARKQVLQQAFVSHVPAAWSMTPTVGIGASAGARAAEDGKTESVEDMLLRKEASRAMGVDEEVFDDDVRLVEQAYHWESKYEARKPRYFNRVHTGYEWNRYNQTHYDANNPPPKVVQGYKFHIFYPDLIDPFKAPTYRVQPDPDGPGETVLLRFSAGPPYEDVAFRIVQREWDYSFKRGFRSSFDRGILQLHCTCTYRERRRAPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSN5</accession>
    <name>A8PSN5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732514.1">
        <property type="nucleotide sequence ID" value="XM_001732462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSN5"/>
    <dbReference type="STRING" id="425265.A8PSN5"/>
    <dbReference type="GeneID" id="5856820"/>
    <dbReference type="KEGG" id="mgl:MGL_0289"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0289"/>
    <dbReference type="InParanoid" id="A8PSN5"/>
    <dbReference type="OMA" id="KVCISFT"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="6"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="296" mass="33029" checksum="E9D05E01D50BF8B0" modified="2008-01-15" version="1">MSSRGSAVKRIMSEMKEMSSQENIEFSAAPTEDNLFEWHFTLRGPQDTVFEKGMYHGKIILPSEYPFKAPHVIFLTPNGRWALDTKVCISFTGFHEESWQPAWGIRTALLGVQALMSSKDDEAGYGAESMNDEGRKMLAEKSMAWTCAICQKTNAEMLPGERAIQSTTTNELPGTPNMTKMDRTSLPAKEPSSETKSDAKTAQKDEKHTTYRNQCFMDEKEEEHGPSTQVSEPTPHQSKPAPSDPSAAFQTSSNLPTSISEVLQTRVESYRRTIGMIDTLMGLICAMLFLIVLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSY0</accession>
    <name>A8PSY0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_0335</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732560.1">
        <property type="nucleotide sequence ID" value="XM_001732508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSY0"/>
    <dbReference type="FunCoup" id="A8PSY0">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSY0"/>
    <dbReference type="GeneID" id="5856866"/>
    <dbReference type="KEGG" id="mgl:MGL_0335"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0335"/>
    <dbReference type="InParanoid" id="A8PSY0"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000002">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006779">
        <property type="entry name" value="PRK09293.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="209"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP45346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="340" mass="37271" checksum="82A8BB7827FF667B" modified="2008-01-15" version="1">MENQQHQTDIITLSRHVLSEGIRARTQNDAVTGEMTLLLTSLQTICKVIENMVRKARVNNMVGIAGNQNVQGEDQKKLDVLSNEVMVKLLIASGQSAVLVSEEEEQVIIVKDHGGHAGKYCVVFDPLDGSSNIDAGVNIGTIFGIYRVREGSEGTLQDVLRPGREMVAAGYCMYGSSANIVLSTGSGVNGFTLNNDVGEFVLTHPNIEIPTRGNIYSFNEGNSMYFHEPVLKYLESIKFPGEGKKPYSARYIGSMVADVHRTLLYGGIFGYPADKKSSSGKLRLLYEGFPMAFLIEQAGGVATTGEKRVLDVEPTKIHERVPVFLGSKDDVQDLLSFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTD3</accession>
    <name>A8PTD3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732631.1">
        <property type="nucleotide sequence ID" value="XM_001732579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTD3"/>
    <dbReference type="GeneID" id="5856937"/>
    <dbReference type="KEGG" id="mgl:MGL_0406"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0406"/>
    <dbReference type="InParanoid" id="A8PTD3"/>
    <dbReference type="OMA" id="CEEHEAL"/>
    <dbReference type="OrthoDB" id="2549886at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="575" mass="64613" checksum="752A59623ABD6047" modified="2008-01-15" version="1">MLGQLVQHIYIGSTSIYAERPVLGLSHGFHSYEEAFSIVPEIQRRPSDHPCTPHGSLLSHTLERDIAEVCAMHVGSEAPNGTRTGGITIQQPGLDYFGHIIPRSEWVMRAFEARSLLLWLRFLVHEERGNHIRRWLASPYNVEAHKYTLRAEHPHAVLQIEKYEGVHEIEHDVFEPRPLHSRPAGSRHDPLDWEDAGDMLYALSPSDDDVHTALVWRVLQEFDPSNLPRWLCVLIAKALAYGRWLALCSICDRSYRAEPVFTPIPLRHGAAFFQHDRFDDPYLFARSGALHMIGMGDVPNDVSDPRSEEADLWGATQQIGTSLMCTWERRPFGIALRDWKVPLKETLPQLDSELQLGSEPLPMHTLGSLLQSVHSLLGMLPRVENLGLSGVLERAVAGFRQPVELPHLTRLSLGPPPMFWAHTLVWGDEHHRTFSRVRRLCITGCMLLASEAQALGGAHGALPNLESVVWSMHRSTLAYEAPAIVATIATILAIEIPGKTYAPPPTQRRKGVHHLHVVLHTQAYDDVRRMAPTYIMEDPRLSFGNASVTAPKHVHPVVTDWAHTHSHPICTSDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTS5</accession>
    <name>A8PTS5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732696.1">
        <property type="nucleotide sequence ID" value="XM_001732644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTS5"/>
    <dbReference type="STRING" id="425265.A8PTS5"/>
    <dbReference type="GeneID" id="5857002"/>
    <dbReference type="KEGG" id="mgl:MGL_0471"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0471"/>
    <dbReference type="InParanoid" id="A8PTS5"/>
    <dbReference type="OMA" id="NDTHAPT"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="30"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="258" mass="29403" checksum="F631CCD5F9497000" modified="2008-01-15" version="1">MSSGDKNGLEWLGELRVLVLDPRKETHGAQQQNRTNDTHAPTTRGSQTFVSYGVRAETNLPHFSRTYMITRKRFQDFVFLHDALVSDFPACIVPPLPGKHRIGYLTGDRFSSEFIMRRCMELQLFLERVCRHPLLQRAKILQQFLESNEWHIDMHTHSGQPIASTSGAPTPEVPSSSTGGILESMSDIFVNAFTRVRKPDPRFIAIKAGLEGEEDRTTQWERVLLRNRTHVSGMFSGSLAWLVGCCIARPFRLCARYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU23</accession>
    <name>A8PU23_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0519</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732744.1">
        <property type="nucleotide sequence ID" value="XM_001732692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU23"/>
    <dbReference type="FunCoup" id="A8PU23">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PU23"/>
    <dbReference type="GeneID" id="5857050"/>
    <dbReference type="KEGG" id="mgl:MGL_0519"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0519"/>
    <dbReference type="InParanoid" id="A8PU23"/>
    <dbReference type="OMA" id="QWAIERN"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="90" mass="10136" checksum="DD4A14C0C31181B0" modified="2008-01-15" version="1">MLTLSKIGWWGAFGGPAQKGIKTYSVSPFQQNPFAGVLKGYMFNGFRRAVKHMPYSGIPFLVGYFIYSWGNKEYNYVNSKEGHLAHAGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUG0</accession>
    <name>A8PUG0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0678</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732085.1">
        <property type="nucleotide sequence ID" value="XM_001732033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUG0"/>
    <dbReference type="GeneID" id="5856391"/>
    <dbReference type="KEGG" id="mgl:MGL_0678"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0678"/>
    <dbReference type="InParanoid" id="A8PUG0"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="204"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="528" mass="59285" checksum="B1D8C7FFB791E2AA" modified="2008-01-15" version="1">MPIDIERQPGAADHNEITPFSPDNADSVRNTRLFSPIEEREQRWRELELSLDMSPMDPEAPVSHDKSHSVPLSHVTPPSMVQSSLLTDDESPGRSLTVPLNSSPLQGSAIIAPYSGENQSPAPRRPPDTKPPADLNPSLNLQGNAYLHTTGQATSVPQAWTHDLSSQRMPPSATHVAPAPAFDTRLPEPHRIPPDVPLYDPAQLFCTQCQRARPPRAHHCRKCGTCVLRMDHHCPWIGGCVGAHNYHLYFMTVLWGLILSTYVIVSMAPLFSRGVLSQGSSSSWRDAIHHWSVDGFMISVFAISFFFFLFTGSLVSVHIHMSGHNLTSIEQRAINSLRTREGMVQRRYFSDAGQGGSLGRGPLAAFRRLRARQRMRKAWNDEWGHPLREGNPWWIGSIAEFEYSVSSPSACERERELEKKLGLTRSDAYAHTPQIYGACALATPMTTSRLLRQRQQHHQPVPSFWFVGPPYLLNMQLSLGPPYSWLFPISRRSHTGVHFALNPRYSQDGLWRPRSQWPSITTTSPSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUM8</accession>
    <name>A8PUM8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732128.1">
        <property type="nucleotide sequence ID" value="XM_001732076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUM8"/>
    <dbReference type="FunCoup" id="A8PUM8">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUM8"/>
    <dbReference type="GeneID" id="5856434"/>
    <dbReference type="KEGG" id="mgl:MGL_0721"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0721"/>
    <dbReference type="InParanoid" id="A8PUM8"/>
    <dbReference type="OMA" id="PTWNFCK"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="165" mass="18433" checksum="4B903EC959B4A015" modified="2008-01-15" version="1">MVTFYELKAAMPQGKSFDFAQLKGKVVLIVNTASKCGFTPQFEGLEKLYKDYSPRGLMVLGFPCNQFMSQDPGDDESIGGFCMKVRLLVGNPRSEAVGAGKGQYFIRTFMTDTVVFQNYGVSFPIMAKSDVNGEHANETFKFLKHEQPGLFGSEMISTYSHHWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVF0</accession>
    <name>A8PVF0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metaxin glutathione S-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731575.1">
        <property type="nucleotide sequence ID" value="XM_001731523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVF0"/>
    <dbReference type="GeneID" id="5855881"/>
    <dbReference type="KEGG" id="mgl:MGL_0843"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0843"/>
    <dbReference type="InParanoid" id="A8PVF0"/>
    <dbReference type="OMA" id="NSWASAD"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42828" checksum="8A5B2D06ECB43030" modified="2008-01-15" version="1">MSLAADGTRSESEDMPFVPPSYTPTRSSMIPMPDVIRRLFALFPLRVWPAAQAVSDREVVKMPKDKAELYVIPARATEKNSWASADPICLRWQMEFVFRQVPVHCEPIYHAYWSPDHSVPFALFRSSSKQSGEDLPDTLLLSESNLLRYMDHHHPLARPELDEKSVWPEGAEDEVPIWKNLLERRVMAGVLLSCIRSGVYTPPPSSKPFLRRWFAPLFPGESSPDEVAFARLACISSAGASPASLAAVYGRDYLADAKNPLTLVPGYSVDWVGFLSGTSSHTASDAAEDAEFVPSQLRVDQDAIRRDAAEGLEAVAVRLASDVNVSTGEGWLLGAKRATSLDCLLFAILHTLDTLPLDEARMLRNVMDRHSCLGAYYRRLHSYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVI2</accession>
    <name>A8PVI2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731607.1">
        <property type="nucleotide sequence ID" value="XM_001731555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVI2"/>
    <dbReference type="STRING" id="425265.A8PVI2"/>
    <dbReference type="GeneID" id="5855913"/>
    <dbReference type="KEGG" id="mgl:MGL_0875"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0875"/>
    <dbReference type="InParanoid" id="A8PVI2"/>
    <dbReference type="OMA" id="VTAWWSS"/>
    <dbReference type="OrthoDB" id="4250781at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="2">
        <location>
            <begin position="269"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="455" mass="50769" checksum="715E3F2DA34257F2" modified="2008-01-15" version="1">MSALLRRELHAPTVVASRTYPLCIGADTRLYIHVEHDAHESKLPTDNGTAAVEQGRIVHLIRIDASVDALSAPDAVMRVLSPCAPYTHPSQEPNDNSLVARAQRMAQASLNKDLTFVQVWTCLYAFFTLWPDQEWFVLTSDEQDPWRLPLLASGLAIPHPAHVNASYNVSSTPQAHVNAHGHAPLLVSRAAFWQGAGPFGPSIWVPTLEPGTTFPVVLGTHKLSAHGVTTTSLHPFRAPPKTMDTGVAARSLPIYRRFIPELGQTLTFRCASSASDMDVDLLHKWHATERVNTGWRQDMPREAHKKYLEEQEASSDSLALIGEWDGEPFGYMEVYYAKESALRTYFDAGDFDRGFHALVGEERFRGPHRVRSWMGSLIHMLFLLDPRTMRVVSEPRASNVKMVEYECLCGGHVEKLIDLPHKRAALVYIPRERFFQLCALGPLPSNSSHDASRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVN3</accession>
    <name>A8PVN3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731646.1">
        <property type="nucleotide sequence ID" value="XM_001731594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVN3"/>
    <dbReference type="FunCoup" id="A8PVN3">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVN3"/>
    <dbReference type="GeneID" id="5855952"/>
    <dbReference type="KEGG" id="mgl:MGL_0914"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0914"/>
    <dbReference type="InParanoid" id="A8PVN3"/>
    <dbReference type="OMA" id="HGPMNIP"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="221" mass="24996" checksum="8376AB184FAB8EB8" modified="2008-01-15" version="1">MPQLRLGSVAPDFEAQTTHGRIRFHEWSRNAWAVLFSHPDDFTPVCTTELAEVARRSAEFEKRGVKVIGLSANDITSHARWVKDIRALAKTEVTFPIIGDPERKIATQYDMLDALDPSNVDANGLPLTVRDVFVIDPNHIIRLKISYPASTGRDFDEILRVIDSLQLGDEHRITTPANWRPGDRVIIHPSVHDEEAKARFPDYETVFPYLRLAKDPTSEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVR0</accession>
    <name>A8PVR0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="7">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAN3</name>
        <name evidence="10" type="ORF">MGL_0933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731665.1">
        <property type="nucleotide sequence ID" value="XM_001731613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVR0"/>
    <dbReference type="FunCoup" id="A8PVR0">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVR0"/>
    <dbReference type="GeneID" id="5855970"/>
    <dbReference type="KEGG" id="mgl:MGL_0933"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0933"/>
    <dbReference type="InParanoid" id="A8PVR0"/>
    <dbReference type="OMA" id="NIPCRNE"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pan3 C-terminal knob" evidence="9">
        <location>
            <begin position="449"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="7">
        <location>
            <begin position="497"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="458"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="292"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="358"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="589" mass="64191" checksum="ED2D81214CEB7C01" modified="2008-01-15" version="1">MKAGDDAVPSTRVETKSTDAHSARKDSGTSLSNVLSSSNASLATISFQPRSTPSIRAKLAEAPVFVPRSSNVSSSATMDTHSSPTSPITPHQQVPAMYRHSAGAGAPAAPAPSAGDSSSAVPSSSLTVGAGTAPSLTSSGTPGAAAAAAAASAAAHGPPYSSLAYESFPYDAPSADARAVRHPLQYHLYAPPFPHVSNFHPTHHAAMTFFMDPTLQEELHRKQEAFHAYKATCALDGKCYVLRRIENVQLSHPAAIGTAERWRKIRHPGIVAVREAFTTRAFGDHSIVFVYDFHPLATTLYMEHMTVKPLQPDRRTGRLQPVSMHVPERVLWSYACQLASLLRVVHGAGLAARCIEPSKVLRTGHNRLRLNGCAIFDVLLYQAQPPADALLVQQRDDLTALGRLLLCTGCNNVAAAATLSESFDAFQRTYSAELVHFVHKLVHGEHLSITDTLHELTPYLADEVGSALYHTDLLEAALMRELENGRLVRLLCKLNTVDQRPEYEREGPSNETGERYVLRLFRDMVFHAVDERGHPTLDLSHVLVHLNKLDAGVDERLLLMSRDELNCVIVSYADIKRYVETAFLDLTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVV8</accession>
    <name>A8PVV8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0966</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731698.1">
        <property type="nucleotide sequence ID" value="XM_001731646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVV8"/>
    <dbReference type="FunCoup" id="A8PVV8">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVV8"/>
    <dbReference type="GeneID" id="5856003"/>
    <dbReference type="KEGG" id="mgl:MGL_0966"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0966"/>
    <dbReference type="InParanoid" id="A8PVV8"/>
    <dbReference type="OMA" id="IKFMMRA"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000048">
        <property type="entry name" value="CCR4-associated factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="298" mass="33296" checksum="A2F98E25CBAAABC5" modified="2008-01-15" version="1">MRRWHSLRKAIETYPYVAMDTEFPGIVARPIGQFRGSTDYHYQTLRCNVDLLKMIQLGITVCDEDGNLPPDTCTWQFNLHFDANEDMCAPDSLELLTKAGIDFDRHLQFGIDQQYLGELLITSGMVLLEDVRWVSFHSGYDFGYLLRLVTCQPLPSTESEFFDLLHVWFPCIYDVKFLMRSCKTLKGGLQDLADDLQVSRMGQQHQAGSDSLLTASSFFRLRDRFFDGAIDDAKHLGCLYGFANATSATFTPSGTIVYQALNVTTPVMPHAQTAAVQASAISGGSTPTVTSSPMTTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVY2</accession>
    <name>A8PVY2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731715.1">
        <property type="nucleotide sequence ID" value="XM_001731663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVY2"/>
    <dbReference type="STRING" id="425265.A8PVY2"/>
    <dbReference type="GeneID" id="5856020"/>
    <dbReference type="KEGG" id="mgl:MGL_0983"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0983"/>
    <dbReference type="InParanoid" id="A8PVY2"/>
    <dbReference type="OMA" id="YREPRDW"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="214" mass="25015" checksum="C82E3AD8F63F9959" modified="2008-01-15" version="1">MPPYDRRPARRKTLYVKNFPPSMSASELAYEFERIGPLVRCDIPAPKTPHSKVYAFVEYADPYDAEDAYYDLHGLPIGRYRLDIDFAKNAPAPSWRFGGPTRRRRSPSPRRYAREYEDEMRSSSQAARLDEHMRGERDARDELDQNNDGGLRDEHEQRKGDDVYREHGDHEEYDARRKSEEHQEPSESVAPNRPSTPELADRKPLDREHVVTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWK4</accession>
    <name>A8PWK4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731863.1">
        <property type="nucleotide sequence ID" value="XM_001731811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWK4"/>
    <dbReference type="FunCoup" id="A8PWK4">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWK4"/>
    <dbReference type="GeneID" id="5856168"/>
    <dbReference type="KEGG" id="mgl:MGL_1131"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1131"/>
    <dbReference type="InParanoid" id="A8PWK4"/>
    <dbReference type="OMA" id="LYADKMV"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="201" mass="21720" checksum="A3EAF9CCD9EBB4F1" modified="2008-01-15" version="1">MPPNTPYKSYAGARSTPYDADGASSRFLNESMADVAGSSSLRTDPASRGRRPFQSSGLFHKDLRLLMYAYGDVANPAPESVAILEEMTVDFLTDLCLRAEPSIYALGLSSSQFAATATDANGDSPASSALRGQPSAMQTYRQRAKLDDFKHALRNDRKKLGRLEQLLYADKMVQEARRIGGVEDVAASAGALLHGESRQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWM9</accession>
    <name>A8PWM9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1156</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731888.1">
        <property type="nucleotide sequence ID" value="XM_001731836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWM9"/>
    <dbReference type="FunCoup" id="A8PWM9">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWM9"/>
    <dbReference type="GeneID" id="5856193"/>
    <dbReference type="KEGG" id="mgl:MGL_1156"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1156"/>
    <dbReference type="InParanoid" id="A8PWM9"/>
    <dbReference type="OMA" id="EYVFNVF"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="190" mass="22082" checksum="9B4F025DAAD95FFB" modified="2008-01-15" version="1">MGKTQSKLTPEQLTELQNITYFDRKELQQWYRGFMNDCPPGVLDKEEFSRMYKQFFPFGDPTPLAEHVFNVFDANKNGYIDFKEFICALSVTGRGRLDEKLRWAFQLYDIDGDGTITYNEMLTIVRAIYKLTGQMVKLPPDEDTPEKRVDKIFALMDRDKNAELSFEEFKEGSKQDPSIVQALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWP9</accession>
    <name>A8PWP9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731908.1">
        <property type="nucleotide sequence ID" value="XM_001731856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWP9"/>
    <dbReference type="STRING" id="425265.A8PWP9"/>
    <dbReference type="GeneID" id="5856213"/>
    <dbReference type="KEGG" id="mgl:MGL_1176"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1176"/>
    <dbReference type="InParanoid" id="A8PWP9"/>
    <dbReference type="OMA" id="NFNGICK"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="290" mass="33050" checksum="F0F5526E2564CF43" modified="2008-01-15" version="1">MAAIIMTFIMLWHVHSKYTAVGRKEILFFLYTYCVSEFLVMFLDSAVIPTHTGAYLWVTSIYIGLKSGLFWILMLNGFIGFQFFEDGTLWSLLSLYISSFIIWLIAFLVSSQTFTNSINGTGGLWFFEFAFPIIMVAIYVISQVILVLRTLDELWPINDIVLGCLAFTAGLILQYGFNNQICKSVKHYIDGTFFGTLCSLLAVMMVYKFWDSITKEDLEFSVGARHSNWDAKDLSSMGTDFDSTFQSRANSRTFDNSRTPSPYDHKEAMQSQFGLSVRRHSSGDSFVIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2024-01-24" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWW7</accession>
    <name>A8PWW7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731975.1">
        <property type="nucleotide sequence ID" value="XM_001731923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWW7"/>
    <dbReference type="STRING" id="425265.A8PWW7"/>
    <dbReference type="GeneID" id="5856280"/>
    <dbReference type="KEGG" id="mgl:MGL_1243"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1243"/>
    <dbReference type="InParanoid" id="A8PWW7"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="88" mass="10024" checksum="0CB0C58E4AFEDB6A" modified="2008-01-15" version="1">MGRPPAYLDVSDAQVHFDTQSKRWIWEDDSGIEYEWHGQEPSKEAANDARITAGGWVRVIGDDEMAKQQEGYRMDGVDEHVGVPLRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWX2</accession>
    <name>A8PWX2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase Y-family little finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731980.1">
        <property type="nucleotide sequence ID" value="XM_001731928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWX2"/>
    <dbReference type="STRING" id="425265.A8PWX2"/>
    <dbReference type="GeneID" id="5856285"/>
    <dbReference type="KEGG" id="mgl:MGL_1248"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1248"/>
    <dbReference type="InParanoid" id="A8PWX2"/>
    <dbReference type="OMA" id="WHFAREL"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase Y-family little finger" evidence="7">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="225" mass="26134" checksum="D154D20D5AAA4D4B" modified="2008-01-15" version="1">MSVKNFRPRLTSSKMALSWLAVLSSELSKRLQEEREDDPRMFPRTLVLRYLISNSSGVKSHQVPFGQIANEHLDHEIYTRAEKLWHESIGRVMHRPGPSRVELSLLALSFASIDRTVRDQQPLHNFLSPQVHNKRKADMNPEERMCSKSVRTTKYNDYEVVKDEASLTDMAQWTCSICSHTLHVPIFEDPESHCDNTEPPSFLQILAQARMEHEHWHMAMKLAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWX6</accession>
    <name>A8PWX6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1252</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731984.1">
        <property type="nucleotide sequence ID" value="XM_001731932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWX6"/>
    <dbReference type="FunCoup" id="A8PWX6">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWX6"/>
    <dbReference type="GeneID" id="5856289"/>
    <dbReference type="KEGG" id="mgl:MGL_1252"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1252"/>
    <dbReference type="InParanoid" id="A8PWX6"/>
    <dbReference type="OMA" id="REERHGW"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="82"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="585" mass="64118" checksum="C44737F7324E8D26" modified="2008-01-15" version="1">MGVFQRWFDSFKPAERGIGKEPNYMGELPSEHHSHIDAKEKDKDTLGKDEFTNTTVAVKTEDGGVALIPEETGLKRSLEGRHIQLIAIGGSIGTGLFVGSGITLATGGPGSLMLAFIIVAVMVISTIFSLGELAAVLPISGSFSTYSVRFIDPSWGFAMGWNYWLQWLTTFPLEATAATIVISFWDKDEVVPRGVWVTIFILTISFIHIFGARGYGEFEFIAASLKVIGCIGFIICAIVIDVGGSPAKTYFGAHAWHENPAFLNGFKGFCSVFITACFAYSGTEIVGIAAAETSSPRKHIPKAAKQVIMRVLIFYIVSLLMVTLLVPASNKHLEGDGNDPSNSPFVLAIQTGQIHALPQIFNAVILISAFSVGNASVYGGCRTLLSLAELGMAPKIFTYVDRQGRPLPAMGVSLLFGLLGYLIYASNPNTIFNWLVSISGLSVIFSWASTCVAHIRFRKAWLRQGNKLEQLPWVSPLGIPGSIFSVVLNILVLIAAFYNAAWPIGEGTMTAGDRVNNFFESMLSLPIILLTFILHKIIRRTRHVRIDEIDVQTGRRDPVSEEVLEQERAEWRAKPVYLKIWNTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXB6</accession>
    <name>A8PXB6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731209.1">
        <property type="nucleotide sequence ID" value="XM_001731157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXB6"/>
    <dbReference type="STRING" id="425265.A8PXB6"/>
    <dbReference type="GeneID" id="5855516"/>
    <dbReference type="KEGG" id="mgl:MGL_1392"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1392"/>
    <dbReference type="InParanoid" id="A8PXB6"/>
    <dbReference type="OMA" id="GANQSEM"/>
    <dbReference type="OrthoDB" id="2290255at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="179" mass="19194" checksum="5D67D43BC5CD494D" modified="2008-01-15" version="1">MGRQFLQGQGGAQSQQGAQGVQDFGFHPDHAASHASSHDVKNGDASGSNTSIFSQVTSMLHGKHQQGEIKDDLDHNQLLSTFKKVQQGQKASSQEVGQASAVNAVKQFFGNNEHKEQGGINALVGKAMSIAGQHASGSDKHDAMNHASETIMKMAMKHKMHNMLGGYNEGVSELMDFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXN9</accession>
    <name>A8PXN9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731308.1">
        <property type="nucleotide sequence ID" value="XM_001731256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXN9"/>
    <dbReference type="STRING" id="425265.A8PXN9"/>
    <dbReference type="GeneID" id="5855615"/>
    <dbReference type="KEGG" id="mgl:MGL_1491"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1491"/>
    <dbReference type="InParanoid" id="A8PXN9"/>
    <dbReference type="OMA" id="AKCRVER"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="178" mass="19688" checksum="062BD43070147DF6" modified="2008-01-15" version="1">MNPLQSAQHPCRAEHGMPYVLVLAGNAQRAADIARTLRTFMPGSSAERVKRPRKGKRDDVSAASTSKDEKAAAPAPVVAKLFARHFKVEEQDAWLRAQPAPLGVGTPHRVHTLIQQGSCRLDHLAALIIDFSWTDAKQRTVFDTPETRGAMLHLLSDKHVRAAMQRKMPQPACRLALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXQ5</accession>
    <name>A8PXQ5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">10 kDa heat shock protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731318.1">
        <property type="nucleotide sequence ID" value="XM_001731266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXQ5"/>
    <dbReference type="FunCoup" id="A8PXQ5">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXQ5"/>
    <dbReference type="GeneID" id="5855625"/>
    <dbReference type="KEGG" id="mgl:MGL_1501"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1501"/>
    <dbReference type="InParanoid" id="A8PXQ5"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7382" checksum="22556545D1E9E55D" modified="2008-01-15" version="1">MPEASVIAAGPGAPNKDGHVVPTSVKPGDKVLLPSWGGNSIKVGEEVRTMLLRVRDHVREHASPVKYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXU5</accession>
    <name>A8PXU5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731344.1">
        <property type="nucleotide sequence ID" value="XM_001731292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXU5"/>
    <dbReference type="STRING" id="425265.A8PXU5"/>
    <dbReference type="GeneID" id="5855651"/>
    <dbReference type="KEGG" id="mgl:MGL_1527"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1527"/>
    <dbReference type="InParanoid" id="A8PXU5"/>
    <dbReference type="OMA" id="CNGDWQA"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="667"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="690"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="87106" checksum="2F83EE67D9BFF6F9" modified="2008-01-15" version="1">MANERLGFLEEALTSYSRAISFYERARGSATSKAARTTPFIDEMERWAECALYRHALLTVYAQPAQAASALRAYEVHESRWPGTFRQPQRNVIRALFARLTQPNEPSRAAPQVLKPVSARTTATRRPRPAPTTAHPFSTVKSTVVRLLQQDPGFPRANESNAHPETLAEQLVESWRSQCGANSAMEADDVVTLLYGLAGITFRSQTIQRLLVHMLFAAEAYAEAYAIVPKYMALVDTTWKAHGVPAQRSTAELRAIDGPREYVDTVLLGAHIALRYMNDPRQAQEWVDELLLVGTSDKSSRHRFTMEPALLARTLRSAGEVRVAQVRLVAPAERTGLMDDARVFLQDSLSLDNDASETCYILACILALERQFDDALKHARRALELEPAFVDAWHLIVLLLSARKDFLGARNLASEALAQVEADDDASDAQIAAGSRADPRTQLLSFDYPPTAFQRAGSYIRLLVTHNVLLELTMGAASALDAQRDLFAAYHVRVAPLCASPAPASNEPDAVFMRAPSMMLKPKAELAETPTHARNMFRARVGTQLLQRLWLLSAASFRRIGDLEQSRCAIAEAEQLDARFAEVWVQLAQWCLVSGPSKAGAAVTCLYKALSCDTNHVAASVHLARVLLRPSEQLNMRASHAESIAAVASAASSEQMPLSDFALADDPGIASAGDAENHARATPSRGLGGSSPTATNPKTSPDQEGNGALGDVALPFRWQHDVPPVGRTAWPRLSCAPSTLFHGWDVSEAWHTLGQLAQQTKRSVDVQRRAFLEALRLESTRPIRPWNAALDMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXZ5</accession>
    <name>A8PXZ5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleosome assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731376.1">
        <property type="nucleotide sequence ID" value="XM_001731324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXZ5"/>
    <dbReference type="FunCoup" id="A8PXZ5">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXZ5"/>
    <dbReference type="GeneID" id="5855683"/>
    <dbReference type="KEGG" id="mgl:MGL_1559"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1559"/>
    <dbReference type="InParanoid" id="A8PXZ5"/>
    <dbReference type="OMA" id="YSGDFMY"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49954" checksum="234CB17CDBA940B2" modified="2008-01-15" version="1">MDIGKKRDADLTAPTPQNTPQTNAPIQRERLTRPTVSTIGEEDEGASGMAAAALPNAALTGMIQDRLSSLVGQSSGYIEALPEEVRRRVEGLKGLNVQHQKLEAQFQREILALEKRFAKLYAPLYDRRKQIVLGEVEPTAHEVEEGEATDKLDDDDDEDDDEEGDGDDGVDQSRKSLANMSIRTDAPKGIAEFWLTALKNHVALSELITERDEGALRHLIDVRLRYLDSASEDGAGSSSSAAGVPAPGQVQQGFQLDFSFDADKNEYFKNPVLTKTYFYQDQVGFTGDLVYDHAEGTSIDWTSPENNLTHRLETKKQRNKNTNETRTVKRLVPTDSFFNFFSPPKPPRDDDEDEADEDELDSLEERLELDYQIGEDLKDRIIPHAIDFFTGKALQYENPDEWDDDDAFDDYDDDDDEDGDDDDVRAQAVGGNASAERQNPQECKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY21</accession>
    <name>A8PY21_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical acid sphingomyelinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731391.1">
        <property type="nucleotide sequence ID" value="XM_001731339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY21"/>
    <dbReference type="STRING" id="425265.A8PY21"/>
    <dbReference type="GeneID" id="5855698"/>
    <dbReference type="KEGG" id="mgl:MGL_1574"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1574"/>
    <dbReference type="InParanoid" id="A8PY21"/>
    <dbReference type="OMA" id="WIIAHLP"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725033" evidence="4">
        <location>
            <begin position="21"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="257"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="668" mass="75071" checksum="6C33A75C21EEE012" modified="2008-01-15" version="1">MRWLTAAAALAVTLASSALAIDTTSGTPVYTASKSFPTSLFPSMDYMPKRMEGEPRPHITKEGGKGSYPDSLVNPRSLPTAPPKSETLQAQPHRGTADLDQLIKSVWEVASKLFKHDKASSLTCNLCRNVLDSLQKIARTDPDTIPDLAGSLCEAFNIFGLAGFHQECKRTLSKDVFGGAITQVLSYANFTDGAPDALTVCSQFSFARFCDRPDVSLSEDFLNDWFRGQRHAPKDVIDDWHNKRENAYKNYNPKDNLRVAHVSDLHLDPRYFVGGEADCTYGATVQCCRSNSVNFLKFQDHFVDGTLRDDQIMHKANYWGSLKCDTPWALLASSMEALKHVGGDNGYDIALFTGDLVAHDDPYRYSHDFVKYSEQAQFDMLKHYLGNTPLVPSLGNHDTTPLNCMAASQWYPDNLQYQWDWDLNYVAELWKNRGWVNDNAVKDIKVHHGAFSMKPRKNLRVVSLNTDFWYVANFYNYIHSSNPDFSGMLRFLTDELLEAEKNRERVWIIGHVLSGWDGSQALANPSNLFYQNCQPIRSTDARLPEFDDLVDSKADHGPVWRKLYSARDTYGDFHASVQANSYSAGVNLDGTKWPKNAPLNGTFWAALTDEMEQRPELVETFALVGTRMSPIARRCKDKKCAKANVCYMRAGSANLGEKCDGMYSAFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYH1</accession>
    <name>A8PYH1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1661</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CWC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731478.1">
        <property type="nucleotide sequence ID" value="XM_001731426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYH1"/>
    <dbReference type="STRING" id="425265.A8PYH1"/>
    <dbReference type="GeneID" id="5855785"/>
    <dbReference type="KEGG" id="mgl:MGL_1661"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1661"/>
    <dbReference type="InParanoid" id="A8PYH1"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="135" mass="14781" checksum="8102FFCB95E91C30" modified="2008-01-15" version="1">MNSVGEAADARAGSFGVDLDAEEEDDDDNIPFACLLCREPFTNPIVTLCGHYFCAKCAIARFAKTPKCFACGAKTNGLFNSATRIIERMNKRQATKQEARAERRRMHGLDDGEHHTDELSQDGIIIDSNETPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYI8</accession>
    <name>A8PYI8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731487.1">
        <property type="nucleotide sequence ID" value="XM_001731435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYI8"/>
    <dbReference type="FunCoup" id="A8PYI8">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYI8"/>
    <dbReference type="GeneID" id="5855794"/>
    <dbReference type="KEGG" id="mgl:MGL_1670"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1670"/>
    <dbReference type="InParanoid" id="A8PYI8"/>
    <dbReference type="OMA" id="IDDQEAC"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="45"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="309" mass="34432" checksum="9910BC56D4BA360B" modified="2008-01-15" version="1">MSTEAGINPTSEISSQEEPRGAQPALNKVDSTTYSDESLPEWTCHVGIATEKNGRWRRTMEDAHLYLQDFNNVPGQGYFAVFDGHAGKFAAEWCRDNMNRILSEELNVCPHMDVREVMRNAFLKADEQLEAESRSAGVRSGCTAVTSLIRLESDDSDQNKSRRRVLYTANVGDARSVLCRGGKAIRLTYDHKGSDEFESKRITEKGGFLLNNRVNGVLAVTRSLGDFSIKEFVVGTPFTTSIDMCDEDQFLIVACDGLWDVVSDQDAVNFVSKYSDAQEAAENLLQHALKNFSTDNTSVMIVRFAKTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZK6</accession>
    <name>A8PZK6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730928.1">
        <property type="nucleotide sequence ID" value="XM_001730876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZK6"/>
    <dbReference type="STRING" id="425265.A8PZK6"/>
    <dbReference type="GeneID" id="5855235"/>
    <dbReference type="KEGG" id="mgl:MGL_1927"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1927"/>
    <dbReference type="InParanoid" id="A8PZK6"/>
    <dbReference type="OMA" id="RCSWDIR"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="467" mass="51736" checksum="E629B8C1F55AE221" modified="2008-01-15" version="1">MAVSAPGSYAVVAKSSIPSGEIIARIPCSALFCVRYSDLAKKHALQQALGRYASTLCLALCVLHEQEIGARSTYASYLELIPDVCLPMAWDSKSEASTWLRGTEASRILQRQEYAYKHGLKYTGTCYTELAMFWHDVGESILYDALGAKVSWKAFVRAFSLVSSRAFVIDVFHGLCMVPLADMFNHAAPSNLQVESDMEVCLQCGSNEHIECHVVSANGNIPPNTVDIRTIEPLDAGEEALNSYGELGNAELLCQYGFVSDTKSGWERCSWDIRLPSEREELCNCLGCDPAALDNVEQVRSLEPIYAAQMQRDLCDDGLAPAYTDEDGLAHDFAPISQKNRHDQLCPLFVDAVGRVSWPLWRLALGLENQICSRIHPLDSHLAHWHADRSVSLTPRVKTACERIVQLCQVRLEQLRVFHEDQSIDPPSSTSDALHFAVQHAWQDMSILQACQGRYDTGCTDMGGLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q006</accession>
    <name>A8Q006_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730969.1">
        <property type="nucleotide sequence ID" value="XM_001730917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q006"/>
    <dbReference type="FunCoup" id="A8Q006">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q006"/>
    <dbReference type="GeneID" id="5855276"/>
    <dbReference type="KEGG" id="mgl:MGL_1968"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1968"/>
    <dbReference type="InParanoid" id="A8Q006"/>
    <dbReference type="OMA" id="HRKTQNE"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="28"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="155" mass="17275" checksum="425046A79B6A240B" modified="2008-01-15" version="1">MSVPAFQRLRRGATEVEDASTGKLGPVVEFQDAGCLLVSEVHLFFSRPGESSDRDDGLSAVTQKTKEYVDEFSRYKDQSTIREVRALLIKHAAQPDMEDEDEKGLQLTQFEMAQLANLSVTDIDEARTLIPTLASKDDAQLESLLHELTAIRSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q069</accession>
    <name>A8Q069_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730991.1">
        <property type="nucleotide sequence ID" value="XM_001730939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q069"/>
    <dbReference type="FunCoup" id="A8Q069">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q069"/>
    <dbReference type="GeneID" id="5855298"/>
    <dbReference type="KEGG" id="mgl:MGL_1990"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1990"/>
    <dbReference type="InParanoid" id="A8Q069"/>
    <dbReference type="OMA" id="GMIMLAD"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="281" mass="29903" checksum="4286C3CE55F56421" modified="2008-01-15" version="1">MSSGEDTVCVTVGVLALQGAFHEHMARFASLNASAKGFCVRPIAVRRVDQLEQCHALVIPGGESTAIALGLRNAGLTEPVREWIRRGRPVWGTCAGMIMLAAIATGGKRGGQELLGGMDIQVGRNGFGSQVYSFECDVQCPALGAKPFPGVFIRAPVVERLLSLPTSTSSSSSDNAQDTIAAVQPDVAPSSLTSAPVKSDHVPVSRSPADMHSSKHSVEPIAWLPATEPIVGESPAQNERAPSRIVALRQGRLLVTSFHPELTTDTRLHCYFVREMVLPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1H2</accession>
    <name>A8Q1H2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730788.1">
        <property type="nucleotide sequence ID" value="XM_001730736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1H2"/>
    <dbReference type="FunCoup" id="A8Q1H2">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1H2"/>
    <dbReference type="GeneID" id="5855095"/>
    <dbReference type="KEGG" id="mgl:MGL_1787"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1787"/>
    <dbReference type="InParanoid" id="A8Q1H2"/>
    <dbReference type="OMA" id="FWRSLHP"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32762" checksum="95A96DBEDE96C717" modified="2008-01-15" version="1">MTSARPKEARICDFLNKELVEHKRVAKGPMIVGLQGPQGSARLTLAHTDLYLPHEAMTALGRAHPTYSLLQGRGQPGTHDVQVGERILRAFRTDANDTVSLPVYDKSAHGGAGDRRAVWKCVNRPVDVVLFEGWCLGFRSLSETELAQMYEEGKSRFSEMREEDAKDRAEFTACGLDELRFVNEQLQGWEQIWYPLLDVFVQFVPVAQDGASPWSLIYPWRLEAEHKMKRTNGGRGMTDEQVYAFVKRYLPSYQLFSRDMRERNRWTGHCLVLEIHADRSMGLCSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1M4</accession>
    <name>A8Q1M4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMA20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730811.1">
        <property type="nucleotide sequence ID" value="XM_001730759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1M4"/>
    <dbReference type="FunCoup" id="A8Q1M4">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1M4"/>
    <dbReference type="GeneID" id="5855118"/>
    <dbReference type="KEGG" id="mgl:MGL_1810"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1810"/>
    <dbReference type="InParanoid" id="A8Q1M4"/>
    <dbReference type="OMA" id="GVENIHY"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="101"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="199" mass="21891" checksum="DD4FEE812184AC53" modified="2008-01-15" version="1">MSFFKKLDPKTDLGTPSSLKSSVQRSIRTKLMEQYADTLGANDGALLEKIWPKKESVTSAKFKREHIQIILLKNLPIFFQHYDGPYIPTLHLLHQYPVLLPTVQVDRGAIKFLLSGANVMAPGLTSAGGRLPDPSRGEKPLAKDTPVAIKAQGKEYEVAIGILQVDTEEIRTQGKGNAIDNIHYLGDDLWVICSKGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2K3</accession>
    <name>A8Q2K3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2203</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730408.1">
        <property type="nucleotide sequence ID" value="XM_001730356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2K3"/>
    <dbReference type="STRING" id="425265.A8Q2K3"/>
    <dbReference type="GeneID" id="5854710"/>
    <dbReference type="KEGG" id="mgl:MGL_2203"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2203"/>
    <dbReference type="InParanoid" id="A8Q2K3"/>
    <dbReference type="OMA" id="GEMANIF"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="12">
        <location>
            <begin position="316"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="520" mass="58275" checksum="4F141B24E2B869BD" modified="2008-01-15" version="1">MSEYSFVIPFPGGSQADAERGHGFHAILRLAPALGNTGFPTDRTCRGRRLAVFTHGLLSHKNGIFFKPLASLLDMDSLRWDMSGEGSTPGTWHAGHYDDAADELFHVVNYMHQRFGYVVDLMIGHSKGCAVQATYISRYCTPWPMRQHRPPSRMIFVNGRVFMSRIRRLDAKFQPDFDKQGYSSLSLTVRGQKVEFKLYPEDHESQCSFPAHVHYANLPNHIQCYIAHGTLDNVVPVIDAGEMANIFTAQPGRPAGSVHVNLIEQGDHNLKGDALQVFLDGVRLWLEQTSSTPALLGNRMLISNPTNGERGVFIVVEGLDRSGKSTQVDRLVQTLGPRARLVKFPERTTPIGSMIHSYLKNQTDACDQTVHLLFSANRWELLSSIVQSLRDGQHVICDRYIFSGMAYTHAKGLDLAWCTAPDVGLPVPDLTLFLDLDESTATKRAAYGEERYERRAFQRLVRHAFENVEQLMLRSGARWERLDASGTLDDVWQAVHAQVQEVVSAPRSASLFSWISALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2R1</accession>
    <name>A8Q2R1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730426.1">
        <property type="nucleotide sequence ID" value="XM_001730374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2R1"/>
    <dbReference type="FunCoup" id="A8Q2R1">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2R1"/>
    <dbReference type="GeneID" id="5854733"/>
    <dbReference type="KEGG" id="mgl:MGL_2222"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2222"/>
    <dbReference type="InParanoid" id="A8Q2R1"/>
    <dbReference type="OMA" id="GHQFQER"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="568"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="127"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="201"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="626" mass="69995" checksum="D91282EC034D6FDF" modified="2008-01-15" version="1">MLVVPSNISDQTLALAAKHRSKGRIPVLTYYHRANAATITRSSQPMVGIAQNRSFQDERLVEAIFSSHMSPDAVTTSTERVYGSTLTNLIIDARPTTNAMANYAKGAGSENMEYYKNSKKVYLGIDNIHVMRDSLAKVQAAFRTIDEQLLLDSQQEQSQIADISLALQRSHWLKHLEAILQGTLLIVRNVNVHSSHVLVHCSDGWDRTAQLTSLAQICLDPYYRTFEGFAVLIEKDWLSFGHQFQERHGLVHGSPSKFDMTPPVHESTHDLDASDHDQQLADNPRGVPSFWDFTKTITAHFQANGASQCAPIFFQFLDCVWQLQYQNPDRFEFNGGYLAELVLQIFSGTTGTFLFNSERERQSPLLPNKERSPSQSTPSVWDELLPRRGMWRNSMYNSCLDSTHGHGDQGVLFPRPKDVRFSADLFRHSDTCLNALVDAKRLEYQRFHERLAEAGQFVPAKSPATSDTHAEQRSPEEAFQMAARSVRSLFSDGWNRMQEALRKSTENAGMPEPAPKDSESDMAIRGGYAPALHEHHHNPWVSKRPDDWQSFDALSMDDVNCNARASTTPISLAQPSTSWPSMMSSSPPTSREISASTSAQHLHHELPSTAASALTASTDPLGVTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2W9</accession>
    <name>A8Q2W9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Redoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730463.1">
        <property type="nucleotide sequence ID" value="XM_001730411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2W9"/>
    <dbReference type="STRING" id="425265.A8Q2W9"/>
    <dbReference type="GeneID" id="5854770"/>
    <dbReference type="KEGG" id="mgl:MGL_2259"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2259"/>
    <dbReference type="InParanoid" id="A8Q2W9"/>
    <dbReference type="OMA" id="MCADSTH"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20979" checksum="556EE6733D7908FB" modified="2008-01-15" version="1">MSSAVHEAPLRPPIDASVMHLIGHPLPVLTNLACTDRGSVDLFMASLSRPILVSSLSLPTLQTDRGSQIDLHAALSCDGARQLESLGCQYGALKQTKPELALYGLCTHNVDDLARVRDAMQLPFELLSDPDADLASKLELPMSQHNDWALMPCTLLMEEGRILHVDYPIDDVRETGVRALELLRKTMDPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2X9</accession>
    <name>A8Q2X9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730470.1">
        <property type="nucleotide sequence ID" value="XM_001730418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2X9"/>
    <dbReference type="STRING" id="425265.A8Q2X9"/>
    <dbReference type="GeneID" id="5854777"/>
    <dbReference type="KEGG" id="mgl:MGL_2266"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2266"/>
    <dbReference type="InParanoid" id="A8Q2X9"/>
    <dbReference type="OMA" id="GARCHRT"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="280" mass="31204" checksum="14CF1A4FA3067B08" modified="2008-01-15" version="1">MAEDFGARCHRTLNDNITHLVATSPRTSKAQQAFRKQKIQVVWPSWLNDSICRWVRQGEVPYLIPQDTQISLASLGAQEVDSVSADEGNDPNAAAVAMDASLANMDWGEAEDEVDAFLDDDEEEDENEDQDKENRENGIHASWNHHENRQGGNESDADDYNAGTAEADAPSETNSLMLESDQDSLLLSPLSKRRRIAALRGGKSKLREKVHVDDEPEEPTSSDTEPVSTKRRKLQDSKTIPPSHVEQLKLREQTASPAPSEEILDDLALEMEKELGEDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2Z4</accession>
    <name>A8Q2Z4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ADP/ATP translocase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730480.1">
        <property type="nucleotide sequence ID" value="XM_001730428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2Z4"/>
    <dbReference type="STRING" id="425265.A8Q2Z4"/>
    <dbReference type="GeneID" id="5854787"/>
    <dbReference type="KEGG" id="mgl:MGL_2276"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2276"/>
    <dbReference type="InParanoid" id="A8Q2Z4"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10574" checksum="4B992CCB86C13F3C" modified="2008-01-15" version="1">MDFFWLGALSKLIATSITYPQIVIKSRQQAMSIESSVGKKKVNVWSAMAEVVQDEGFGGLYRGISSKLLQSILTAAILFASKERIYNLTKSLLTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q360</accession>
    <name>A8Q360_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="14">IMP dehydrogenase</shortName>
            <shortName evidence="14">IMPD</shortName>
            <shortName evidence="14">IMPDH</shortName>
            <ecNumber evidence="14 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">MGL_2318</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="14 20"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730522.1">
        <property type="nucleotide sequence ID" value="XM_001730470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q360"/>
    <dbReference type="FunCoup" id="A8Q360">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q360"/>
    <dbReference type="GeneID" id="5854829"/>
    <dbReference type="KEGG" id="mgl:MGL_2318"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2318"/>
    <dbReference type="InParanoid" id="A8Q360"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 14 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="126"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="188"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="14 15">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <begin position="282"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <begin position="332"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 17">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="372"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="395"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="419"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP43308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="551" mass="59522" checksum="F71EC6FED35B8B47" modified="2008-01-15" version="1">MAKVFGEDILPPSAAKKELGSYENRDGLSIGELIDSRKNGGLTYNDFLVLPGYIDFPASKVDLRTRVTKDIVLNTPFISSPMDTVTEVNMAISIALMGGMGVIHNNMSPQEQAAMVRKVKIFENGFITEPLVLSPRETVGDVLEIKERLGFAGIPITETGSLKSKLVGIVTARDIQFRDPSTPLIEVMTRELVTAPTGITLEEANCILRDSKKGKLPIVNAEGDLIALLARSDLMKNQDYPLASKRPDSKQLYCAAAIGTRPHDRERLAMLEEAGLDVVVLDSSQGNSTYQVEMIRWIKQTYPKLQVVAGNVVTREQAATLIEAGADALRVGMGSGSICITQEVMAVGRPQGTAVRQVAEYAKRFGVPVIADGGIQNVGHIAKALCLGASAVMMGGLLAGTTESPGEYFYREGQRLKGYRGMGSIEAMEHQSKKRRFDGATGRATKKVEQVGTDVSAENAATQRYFSESDAVKVAQGVSGSVQDKGSIKKFLPYLYTGLQHSLQDMGVPSVDALRDSVTSGAVRFELRTASAQLEGGVHGLMHYEKRLFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3I6</accession>
    <name>A8Q3I6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_2414</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730618.1">
        <property type="nucleotide sequence ID" value="XM_001730566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3I6"/>
    <dbReference type="FunCoup" id="A8Q3I6">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3I6"/>
    <dbReference type="GeneID" id="5854925"/>
    <dbReference type="KEGG" id="mgl:MGL_2414"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2414"/>
    <dbReference type="InParanoid" id="A8Q3I6"/>
    <dbReference type="OMA" id="IYTRCYS"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="18">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="17">
        <location>
            <begin position="155"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP43404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="369" mass="39213" checksum="ADE32F2191094BB8" modified="2008-01-15" version="1">MSGRIDIALIGVGLVGSAVIKQLASVPALSSLKVVALQNSRKTLLAAPGQALALENWQSQLENNGVPALSLEQLVTELKNIQAKNQRHIAVVDNTSNDSVACFYPSFLHAGFSVVTPNKKAFSGSLDLFSAIEEAKQDDSKPLVYQESTVGAGLPIIGTLKDLVATGDKIKKVEGVLSGTMSYIFNEFSPAAGSTTKFSEIVSVARQNGYTEPHPGDDLSGSDVARKLTILSRLIPGLAYELPRGFASVSTQSLTPAGLADEANADVYVQRLPEFDAEFDEIRAKAQAKHCVLRYVGLIDVEKKVIKAGLEEYPADHPFATSLGGSDNIISFTTERYQRPLLVQGAGAGADVTAMGVVADLVRVAERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3M7</accession>
    <name>A8Q3M7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730654.1">
        <property type="nucleotide sequence ID" value="XM_001730602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3M7"/>
    <dbReference type="STRING" id="425265.A8Q3M7"/>
    <dbReference type="GeneID" id="5854961"/>
    <dbReference type="KEGG" id="mgl:MGL_2450"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2450"/>
    <dbReference type="InParanoid" id="A8Q3M7"/>
    <dbReference type="OMA" id="WIGREEV"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="237" mass="26618" checksum="0868ADF77AAB4DFD" modified="2008-01-15" version="1">MAPTVYWTPPMRTVPSSMDDLEHAVAPSAKPVPTPESVPDVTPSLCLSLIEFKDMLRQFRAIDDGVTLRLNRAFAQSRDLGSSSPPSLLQRHDKSFSSSSAADLGRSTYAVVSETMCESIWSELALLWKRREDTIRYCIDINAQTQQQRNAAPLSQDDRLDLDRAKASPIETSGVSLSRGESTADFTTRQLRNELSIEAIVRRRSLDAFKSRCRLFKPSFKSSLTDSERELAFWEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q437</accession>
    <name>A8Q437_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_2494</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730112.1">
        <property type="nucleotide sequence ID" value="XM_001730060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q437"/>
    <dbReference type="FunCoup" id="A8Q437">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q437"/>
    <dbReference type="GeneID" id="5854419"/>
    <dbReference type="KEGG" id="mgl:MGL_2494"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2494"/>
    <dbReference type="InParanoid" id="A8Q437"/>
    <dbReference type="OMA" id="YIMALRR"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="15">
        <location>
            <begin position="64"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="14">
        <location>
            <begin position="239"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="512"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="17">
        <location>
            <begin position="618"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP42898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="691" mass="77555" checksum="95AB616C1AC44C8B" modified="2008-01-15" version="1">MPHSASSSDESTGPGTPPPGDDVSMLQEEAWAKPHTFHTLEMQRRFMKPSKTEWDVPALRDISRPHIESFNALWSDDPSLDAPGTGDKLSMDSGGLLERSLQTLSPRVVFDGSGEGADRGHRLEMRIDSVSLSRPMVPDRAKDALDRRVFPDECRNRLVSYRGRLTARVTWSVDYGPEQSEIRDMGQVPIMVGSNRCHLRGLTSSELVAKHEEPNEMGGYFIINGNERLMRFLILAKANHVMALERPSFTRRGPSYTSKACSIRCVGRHDLMSITNSVHYLDNGGVTLRFSWRKQEYMVPVVMVLKALVSATDKEIFASIVQADTSNTFLTDRVELLLRSFKQYALWTGEQCLEYLGDKFRVVMRAPEDWSHAQVGEELINRLVLTHLDMPRDKYRLLVFMIRKLYAFVAGECCADNPDSPQHQEVLMPGFLYGAIIKERLDEYLINVRSVIARDVRMHAKECDFFDARYVQRVLAKVNGDIGTRLSSFLATGNLSSPSGLDLQQVGGFTIVAEKLNFYRYVSHFRSVHRGAFFAELKTTTVRKLLPEAWGFLCPVHTPDGSPCGLLNHFSHTCQLTTRDLDVAHIPALLTSLGMTEGVATQISAQTHVCVQLDGVMLGYATPALARHMATVLRVWKTEGLHAVPLDLEIGFVPTSHGGQYRVVYLFSGRARMMRPVRYLFNGREGPCGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Q6</accession>
    <name>A8Q4Q6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730225.1">
        <property type="nucleotide sequence ID" value="XM_001730173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Q6"/>
    <dbReference type="STRING" id="425265.A8Q4Q6"/>
    <dbReference type="GeneID" id="5854530"/>
    <dbReference type="KEGG" id="mgl:MGL_2607"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2607"/>
    <dbReference type="InParanoid" id="A8Q4Q6"/>
    <dbReference type="OMA" id="THSPVDY"/>
    <dbReference type="OrthoDB" id="3366471at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="652" mass="70548" checksum="E9E478AF5AFE9EAB" modified="2008-01-15" version="1">MSPHEHRHLSSARSQSVSVPSTARPTLIKKRESPCFTTTAQFVSPSIHASYARSPMSPSALEAATPKLGHSPAHTDSLPGSPSSVSSTVSGVSLRRGDTADTEDEPEAELEAVDETDELDLDEPTLATLDLSDDSHEHTSSISHITNMYPLPPKLVAIHPKTNTKDRVPSNEAQAEDNDSRTRFLQKGRVSELAAMTNDATRAHPQQNHSCETENKNPPLPSPRGWSGEVVEPPPPHPTVLPQDTVPAVSSPLCVSCDSNNMHDGQVGQQRAVSESRSEPKNNCTQNKGVSAAVDDTNAVEAPEPQDDSTVTSKTSTAGEDMPRPGSMPVRRRSRRSSRAKKPLKSVLSSSEDEPSGRSRRLERKKHSVRFCVDPPEERRTHSPVDYDRKAHPVHNHLCGDDLREMRDLHMSMDLLQSRCRSMHLQQQQQTKEGAPVDMPAYDVWHTTAMHSHTPKTPLPPSGPTSLSAWERNKTDGAPSIPCRRNNSGGDTGSEVRKDDAKSNDPLADLEAVREQQRRHTNGVMPYGSGATTGTGRFLRSASPHDSSAASGLSLPAHNESRLASTLAARFGLNKPPPPLPGMEPSGPVRSAASSPEPATSLRSSARSTSPIGSTLTAQKRASRSVSPHSGYESPMQDFGDYGSEYDMMDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4X4</accession>
    <name>A8Q4X4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730282.1">
        <property type="nucleotide sequence ID" value="XM_001730230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4X4"/>
    <dbReference type="FunCoup" id="A8Q4X4">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4X4"/>
    <dbReference type="GeneID" id="5854587"/>
    <dbReference type="KEGG" id="mgl:MGL_2664"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2664"/>
    <dbReference type="InParanoid" id="A8Q4X4"/>
    <dbReference type="OMA" id="LKVACHS"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725143" description="FAD dependent oxidoreductase domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="470" mass="51900" checksum="8BDFF5A5B1F93133" modified="2008-01-15" version="1">MSAFGHVLIVGAGIFGASTALELARLGHRVTIVDRSQDGYACENASSHDLNKIVRSDYMDAHYRDLGKKAIELWRSHPLYAPYFHEVGIFFYSGVPASNEEPWLRNGVENAIKPIQGAYEFGNHTERPMARTIKSPLEAMHVFPERLRPHLGEALTSFDKQVGYLNPQAGWVEARNATFAVLDEAKRLGVEVVSDATIVELVFASSSSSSSSTQAKPRVCGAVTSNGRTIHADRVVLAAGCWTPSLLETLHVPLKKPILRPSAHCVLTLKIQPDVARLFHGSPVTFNMDTGMYTFEPNPDGILKCAIHGLGSSSPDPRDSTTPAFPHANTNPHVSQMLKHIQAMFPVLQMDGPNKNMDVYYTRFCWYCDTADENFLIDFHPDVDNLLVASGDSGHALKFLPLMGRLITSKLLHIENDSALAPDMGLSAYQRRVFSFEHHMHADKTVNTSMPIDYIRISGIPPAHVPQPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Y7</accession>
    <name>A8Q4Y7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730292.1">
        <property type="nucleotide sequence ID" value="XM_001730240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Y7"/>
    <dbReference type="STRING" id="425265.A8Q4Y7"/>
    <dbReference type="GeneID" id="5854597"/>
    <dbReference type="KEGG" id="mgl:MGL_2674"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2674"/>
    <dbReference type="InParanoid" id="A8Q4Y7"/>
    <dbReference type="OMA" id="GNHFGWA"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="314" mass="35430" checksum="9263228C92A8BC4E" modified="2008-01-15" version="1">MTANKLGDVGLSSFFDALPPTGTPLSELYLSVNTVASESGSWRAARSIANFLSSPKKCRHIKYFHLSGNHFGWAGVRAIVHAILGSRRACTLNGTIAANNIPTDMLDAVAPNTNLVAMDLFSTGIDTLMTSTQEPLPPELEWETYSAVTPDNWSDVLTEHLCRNQDHARACQSASVQLLAVARTIGCKSREANVPSTKVFPFLRLPTELRVFIMQFIDTDNVLSHEQFINILRWASEPSTIQFIREFGAWPPQHSSVPTENIWGLPPWSWEEAYTWRSVPRNWYSEAMEYDEWHRWQPEKLAFWENTGISTPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Z1</accession>
    <name>A8Q4Z1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_2678</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730296.1">
        <property type="nucleotide sequence ID" value="XM_001730244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Z1"/>
    <dbReference type="FunCoup" id="A8Q4Z1">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4Z1"/>
    <dbReference type="GeneID" id="5854601"/>
    <dbReference type="KEGG" id="mgl:MGL_2678"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2678"/>
    <dbReference type="InParanoid" id="A8Q4Z1"/>
    <dbReference type="OMA" id="IRQRHWF"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000554">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP43082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="181" mass="20633" checksum="BBFF166488C3EA4E" modified="2008-01-15" version="1">MGLSVSRLLSGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRERIPEAREELQRMLNEDELRDALLLVFANKQDLPNAMNAAEITDKLGLHSLRQRQWFIQATCATSGDGLYEGLEWLSTNLKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q520</accession>
    <name>A8Q520_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PRP1 splicing factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730318.1">
        <property type="nucleotide sequence ID" value="XM_001730266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q520"/>
    <dbReference type="FunCoup" id="A8Q520">
        <property type="interactions" value="510"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q520"/>
    <dbReference type="GeneID" id="5854623"/>
    <dbReference type="KEGG" id="mgl:MGL_2700"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2700"/>
    <dbReference type="InParanoid" id="A8Q520"/>
    <dbReference type="OMA" id="DGWAWYY"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000384">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="917" mass="101794" checksum="C3E1744130B6DBFB" modified="2008-01-15" version="1">MASGRPNKLAFLSMQAPAGYVAGLGRGASGFTTRSDIGPAREGPSAETVAAARARRGEDEGEDDDDPERFQDPEEETGLFATAVYEKDDEEADRIWDSVDRHMDERRRKQREIREAVEREAIRQSQPKIQAQFADLKRNLASVSESEWASLPEPGNMTGKRRKAASLRESRDNRTYAMPDSMLASARDRNQIQNTAADVDGTVSSLTEIGEARNKVFSHQLDQVSTQSQMASSGTSSTIDPTGYLTELSSVHVKSDVEIGDIKKARSLLDSVIKTNPKHAPGWIAAARLEEVAGKMTMARKVIAQGCELCPRSEDVWLESARLNSRDNAKMVLARAIQFQSQSVAIWLRAMSLETDLESKKRVVRKALEHIPHSVKLWKELVNLEERPEDARVLLAGAVEAVPMSVELWLALARLSSPSDAKSVLNRARRTIPTSHEIWIAAARLLEESGEAAERIDKTMKAAVASLHKAGALLSRDQWLREAEQVDKEGSPLTCAAIVRATMHLDIDDEDRQRVWTEDADTCLEHGRIATARAILSCALDEFPDVLDIWQQAARLERMHGTHELFTALLERGVEQCPQAESLWLLYADDRRRAGDVSGARTILARAFDANLGSESISLAAATLESDLGDMHAAAKLLMRAREEVRTERVWITSVQVAWRQGAYDDALTLAKNALERFPALEAVYTMQARLYETKGDLGAAREALAAGRRACPTSIMLWLLSSRLEERTGALIRARALLEKGRQAHPTSDELWAESAAVELRANSAAQAKTLLSRGLQACPSSGRLLSAAIWLEPRPARKSRAADALRRSADSPYVICTVARLFWDEGRYTQARDWFTKTVQAARTWGDGWAWWYAFEGTQPDGDAQRRQLLDKIELAEPKEGDVWTHLREKPEFAACSLRTLLPVAADEVIKQESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q533</accession>
    <name>A8Q533_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730328.1">
        <property type="nucleotide sequence ID" value="XM_001730276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q533"/>
    <dbReference type="FunCoup" id="A8Q533">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q533"/>
    <dbReference type="GeneID" id="5854633"/>
    <dbReference type="KEGG" id="mgl:MGL_2710"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2710"/>
    <dbReference type="InParanoid" id="A8Q533"/>
    <dbReference type="OMA" id="LAWYRFI"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="559"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="898" mass="101065" checksum="CACEA418EA25A79B" modified="2008-01-15" version="1">MQRAQALEASYTRAMLTFMLGLLCKEHENMDLAKQMASFLLSHGMHSSLRNYLVALPKDAISEQADCVSLMLRPLALFDEPTTEFVQAGAADASSYAPRAVFLRTFTSEILTIPHLLHHMPIPSVSALSSAFPMSEFMHHVQSLGAYYDVTSGDSALANNPIHCPYLLANVIILTAVRVKAMQNGSEISQYLMMLATLQNALPKSVFADEDASVDQKTKNELLTLVSFAHIRSVLAASMRSPHNTRPALCAFLVATLYTWPASARDSVLTAMLYGYDKDGVTRSVYMGILARELWRGWVRSCSLVRCVATKHRGLAANASNVRAVVTDPTYASDWPLFLVLCIEYSRCLMILGDDEFYPSSAIDTHVPSRNPLTLDELDTLSGLLRNITFAMYWNSVDMPPEHAHVPGTRVQLAQVRELCTRLLQQLHTRDSRRSFVREGHWHMLGQNDLGSFIHAVVLEERELASAISHDEDATNARATISALSQRTRAFMTPRLEVLSYIPFVIPFDVRVEIFRQFVRNDAERLGISRDIFSPTRRHRATIRRGHIAEDGMAKLNGLGPSLKEPLEIVFIDQWGMPEAGIDGSGLFKEFLVSIIREVFDTDRGLWCANERQELYPNPHSYAHGEEQLTWYTFLGRILGKALYEGILVDVKFADFFLTKWLGPKGYIDDLASLESLDSDLYRGLIALKNYTGNVENDFALNFTVTDEEFGVRMNRELIPGGNDVPVTRENRLSYIYCMTRYRLSTQIEDQCNAFFQGLSEMIDPRWLRLFNREELRVLVSGAESPIDVDDLRRNTIYGGYHEKDMAVQYFWEALSHFDQSSLKAFLRFVTSSPNPPLLGFGELNPKFAIRHAGDDVTRLPTASTCVNLLKLPAYESVAQCADKLRYAIYAGAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q534</accession>
    <name>A8Q534_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730329.1">
        <property type="nucleotide sequence ID" value="XM_001730277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q534"/>
    <dbReference type="STRING" id="425265.A8Q534"/>
    <dbReference type="GeneID" id="5854634"/>
    <dbReference type="KEGG" id="mgl:MGL_2711"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2711"/>
    <dbReference type="InParanoid" id="A8Q534"/>
    <dbReference type="OMA" id="CHENFLH"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="196"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="687" mass="76400" checksum="41FB4034471E322D" modified="2008-01-15" version="1">MIGITQPRRVAATSLARRVADELGCEDPATLRPRSDVKTDKPAYVGYSVRFDDRTTPQTRIKFLTDGMLIREALGPSISKVGMSRKKNARNFLLKRYRVMIIDEAHERSLRTDMLLGLMKQIQKERKKLIDAGNTTLAPLKIIIMSATIDADAFARFFSNSIKPIPILYVAGRQHRVRLYHTEHSCQDWTDAAVRTVMQIHVSKPLGDVLVFATGQEEIESMVQSLELFQSQLEPWAREEGRDDVPALLVRPLYAALGPAASAAVFTPTPAHTRKIVLATNIAETSITIPGVRYVVDSGLVKEKVFSPHTSIETLQVLPISQSSSVQRAGRAGREAPGECYRLYTRDAFHQLRPMPVAEIHRTELSGAALQLYAMDLNPFTFEWIDPPDTALLQEAVLHLAELGAIQTRKDGIFLTELGYQLASLPVTPSYARLLLAAAEQGTRVASQARDLVSILSADRSIFVEPTQPDKRELAEQAREVFYDVTGDHATMLNAFRAYIAAHDHAYASHVSAAAARQEVRMWCQTHFVHERTVKNILAIRKQLSRICSQHGIVCEETSHHNASHKIESEASDSENDPDALVVTKGASILPQNAGENYMELMQCLGTGRLSHTALRQPDGSFRRVAGGQTFKLHPSCVLHPSRHGARGTSDESVQVIVFEELVLTSQTFARTVSRMEPAWLQTWLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q540</accession>
    <name>A8Q540_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730334.1">
        <property type="nucleotide sequence ID" value="XM_001730282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q540"/>
    <dbReference type="GeneID" id="5854639"/>
    <dbReference type="KEGG" id="mgl:MGL_2716"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2716"/>
    <dbReference type="InParanoid" id="A8Q540"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728093" description="Bicarbonate transporter-like transmembrane domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14756" checksum="3B98E9A75B288368" modified="2008-01-15" version="1">MPSVAMLYASLSTVFLLVLRVIWASKEPVNLGLDSRSRSAINNQAGQLLPMHLTQITSAWNPLAGHTGLTEWIIRHIMGGMSAGVALAAVLPMHPIFGALVILCGLSVQAFVREQLGMPWDATFLSWDATSRYCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q544</accession>
    <name>A8Q544_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arp2/3 complex 41 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">p41-ARC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730337.1">
        <property type="nucleotide sequence ID" value="XM_001730285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q544"/>
    <dbReference type="FunCoup" id="A8Q544">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q544"/>
    <dbReference type="GeneID" id="5854642"/>
    <dbReference type="KEGG" id="mgl:MGL_2719"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2719"/>
    <dbReference type="InParanoid" id="A8Q544"/>
    <dbReference type="OMA" id="IWDVKVT"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="432" mass="46416" checksum="FCDEE72D25E16F18" modified="2008-01-15" version="1">MVNQVHQLSYSPLSAHAFNADRSKVAVSPNTNEIFIFSQSPQGWVLEHTLSEHDKVVTGIDWAPHTNRIVSCSQDRNAYVWTLSGSVWKPTLVLLRLHRGATAVRWSPNEDKFAVASSARIISVCSFEEDNDWWVAKHIKRPLRSTVTSIDWHPNNVLWPAGCADFHARVFSAYIKGVDTKPPPSVWGERLPFGTVCGEFPTPSGGWVHGVAFSPSGDALAYVGHDASLTVVYPAAPESPPQAMHVIRLPSLPYMTLLFISETALVAAGHDCQPMVFEGSIDNGWKLTRSLDTVGTAASKPKPPPPPPKKPGLGAPAATASSGGVGRLNNEAFARFREADSRGKAAAPSTLSTDSTPQSFGAVAGASIADDGELHTTHQNTITDIRIYSGARDHVESISTSGVDGRLCTFETNKGSTAIAPILRGIQSMQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q630</accession>
    <name>A8Q630_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729860.1">
        <property type="nucleotide sequence ID" value="XM_001729808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q630"/>
    <dbReference type="STRING" id="425265.A8Q630"/>
    <dbReference type="GeneID" id="5854167"/>
    <dbReference type="KEGG" id="mgl:MGL_2846"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2846"/>
    <dbReference type="InParanoid" id="A8Q630"/>
    <dbReference type="OrthoDB" id="10531022at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="81"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="196" mass="22288" checksum="E5CF782AE2B6B446" modified="2008-01-15" version="1">MEMEHNHGSRSVSAPAAPLSTPAAETQETRASTQDVDERACDFLELMLEEAERQHKTGFVPMHGSQQKPTAKETTFRGCRFIKERRAGEGGFSTVWQVRGPTAIPASVPGAETDAVRMEPVEEIRQGFFAMKQVSLRRLEPESRDELVQEAKLLEQLAQMPDHEQYVLRYFGHRLNRDTLKIVRSFESDKTCRLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q648</accession>
    <name>A8Q648_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2852</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729866.1">
        <property type="nucleotide sequence ID" value="XM_001729814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q648"/>
    <dbReference type="FunCoup" id="A8Q648">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q648"/>
    <dbReference type="GeneID" id="5854173"/>
    <dbReference type="KEGG" id="mgl:MGL_2852"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2852"/>
    <dbReference type="InParanoid" id="A8Q648"/>
    <dbReference type="OMA" id="NEPIYKH"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="112"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="8">
        <location>
            <begin position="327"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="66901" checksum="ED7BED4755B9CB83" modified="2008-01-15" version="1">MDSTPWREYKSGERSYYVNKETKQSTWTIPADLQAYLSTIPDDPPPAVPARSSASPHAHASPAGSATPPTNTSTGASATASDAVTDALGPGTAAPRSSTNSSVSARNLSPVYATHEEAEAAFMSMLQRKNVGPTSTWEQTLREIITDPLYKALRTLAERKAVFHKYVDDQKAQEAARREEKAAELRPKVTSALQQELGGLKPYASFATFRKKLSPHALWAEIDDEQQAHAIYEAIHREVQEKENARLEAIRAQNRTNWLALLTTMELRPTSRWHDVYRAICDSDTYRQSPQLQTMLFTDQLAVFEEHMAKVEAEERERLWGHAHSRRDRQARDAFRALLQDSVDKGTLHARSTWASYFPSIRDDERLKAMTQTASGSSAQDLFYDVLDTLERDFAVHRRTVQAHMRANNIHVTSTTDSDAWHNAFRSADAPDSIRMLPDHMLRALFDECVYQSERDARDARRRTERRLRHHADDLRYAFKHMEPPLDIEASFDDILPRIRTLPEYDVLARAGEDGLDTARSAWDRFVRRQSEKLADAMNTPGRSRTDYTDLDDSGGADEHRKRKEHLRSDDVTAVDPRAVRRRTEYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6C3</accession>
    <name>A8Q6C3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729933.1">
        <property type="nucleotide sequence ID" value="XM_001729881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6C3"/>
    <dbReference type="FunCoup" id="A8Q6C3">
        <property type="interactions" value="625"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6C3"/>
    <dbReference type="GeneID" id="5854240"/>
    <dbReference type="KEGG" id="mgl:MGL_2919"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2919"/>
    <dbReference type="InParanoid" id="A8Q6C3"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="1023"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1172" mass="129466" checksum="069B69AA5388F482" modified="2008-01-15" version="1">MSAGAAKQTSLLGFFSKAPKQTTPTKEAPSTQDPSSAVSTPPPTAERSSDASSSKHELSSPTPDVSRPAKVPRTSQKTLSASSSLTPPPSSDVTMTEETAPSSSPTQGRRRAARRINYSERHMKLDEDDDDDDDDDDDDTKSQDEFVLSETSSESSDEDASVVESEEPSTADEQEEDPDVQDIAATPPRSKRGRPAGSQRIATETSASARAPAAASASPATSSLPPLTPTPPMYMPRSDSHLTKAEQRVQEEKRKRLENEQAYDFLLDIRDKDMNRPGDMNYDKRTLYIPPSAWKSFTPFEKQFWEIKQQHWDTVLFFQKGKFYELYEEDALIGHRECDLKLTDRVKMKMVGVPEASFDMFATKLLALGYKVGRVDQCETAVAKGMRVGEKSRGGGSDIVRRELRHVVTSGTIVDGSVLADDLSSYCISIKEHVLPSGLSEFGICTLDAATAEFRYMSFEDDAVLSQLETLLRSLRIKEVLHEKGVMSPSTLRLIRNTVPTTCQITMLKPDTEFLDEISTRARLAHLFDSVPDGLAPLAEQGGLALCALGGLLWYLEQLNLDTDLCASGNFQVQTAPADAQGALVLDAKSLMHLHVLQNDEGSDEGTLHRLLNRCTTPFGRRLFKLWLSSPLSKIEAIEARLDAVDDLRANPAWADAFDAFAKSLPDLERLQSRIAAGKCRPRDFLLVLRAFGRFGSAKEQLLTLLSLSESPVSRPSSVLVTLLREWPDVAELAQMLRSHFVSNDDGSFTPVKGECEAYDAAVDSVHAAEARLEAEKDRCVAELRISKREAGWKHVGTNEIYQLEVPARTKVPAPWILMSQTKACKRYYTPRTRELIRELKEARETRVAALKRFQEDVYVWFRQDLPSYARAIRSVAQLDCLVSLAKSSMALGTPACRPELVQQDSAMFRFTQLRHPCMAPSSLTGATEFIPNDVALGADAEDVMVLTGGNMAGKSTTARTAATAVILAQMGCYVPATHARIAPVDRIASRMGANDQLFRRQSTFMVEMLEASKILREATPRSLVLMDELGRGTSTFDGQAIAYAVLYHLVARSQCLCFFMTHYTTMAQSLDTYPRLANRHMEVRVDDEHRHVVFTYRLVPGVAESSYGTQVAHIAGVPADICAKASDVSREFWHEAQRLHAQQAHCSIPLNQLADFARLVTMGRAGAINSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2023-06-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6R8</accession>
    <name>A8Q6R8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730054.1">
        <property type="nucleotide sequence ID" value="XM_001730002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6R8"/>
    <dbReference type="GeneID" id="5854361"/>
    <dbReference type="KEGG" id="mgl:MGL_3040"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3040"/>
    <dbReference type="InParanoid" id="A8Q6R8"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725159" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="132" mass="15069" checksum="E6BA5ABF2FE3C55D" modified="2008-01-15" version="1">MKFSLINALASALLLVGIVKAAPIDSRQMTPDYNPVISQVLETELKERQLTPDYNPVISQVLETELKERQLTPDYNPVISQVLETELKERQMTPDNNPVISQVLEVQENEKRDDGLREPANKHFNWELGMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7R8</accession>
    <name>A8Q7R8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729554.1">
        <property type="nucleotide sequence ID" value="XM_001729502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7R8"/>
    <dbReference type="GeneID" id="5853860"/>
    <dbReference type="KEGG" id="mgl:MGL_3098"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3098"/>
    <dbReference type="InParanoid" id="A8Q7R8"/>
    <dbReference type="OMA" id="EMHYRET"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="389" mass="41793" checksum="2902BE032BF75F2A" modified="2008-01-15" version="1">MLNETRMHIQELANQSHVDRKRKRPLSSAEPQKRVASESSYASSSRVSSGSSTASASSSGTVHVHASSAPPSQTRMSSPPSPSIVPLSPMPTPRPSLPVPPSQRVGPRPCPPSPSRTPRPSLPDPPCSRPERVTVSDPDLANETAPSVYDDREAESVAESEAQSDADELLQSESPTERDDREAAIRVSEANTSDADADVDAAAPTSSSNSEPGRSTPAKTRNTLATPVPSLSRPERVKSPLLASLERAEQRSRTPPPPPPPSLHPEDHAEHKNSNTRVSIMEQDKEQNKENTTGHSDNPKKSDDKPEPQREPFAQVGNHVSSSIPSSGLRARAQKYLQTVERSSSGQVESSPSAADALSTHALKRANTYQPSALSESLRRRMARIESAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7U0</accession>
    <name>A8Q7U0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_3120</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729576.1">
        <property type="nucleotide sequence ID" value="XM_001729524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7U0"/>
    <dbReference type="FunCoup" id="A8Q7U0">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7U0"/>
    <dbReference type="GeneID" id="5853882"/>
    <dbReference type="KEGG" id="mgl:MGL_3120"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3120"/>
    <dbReference type="InParanoid" id="A8Q7U0"/>
    <dbReference type="OMA" id="PHIVKPM"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="13">
        <location>
            <begin position="137"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="14">
        <location>
            <begin position="530"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="714" mass="78184" checksum="D3A57B77C1525F6F" modified="2008-01-15" version="1">MIRSSVWRFSQKASSAAASAATGASAKGAQRKRAAVLITAAAVGAGSVFALTRRPNDWDEYALPHDVSPQQFWSPPTRSQMIEALKQSSSRILRADGSLEQAKSLLMPSHEAVGHSPIPEVEHAYADVPEHDDDGFDLLIVGGGATGAGVVLDAATRGLKVALVERDDYGAGTSSKSTKLVHGGVRYLEKAVKQLDFEQYKMVKEALNERRNFLHIAPYLCSSLPILIPAYSWWLIPYYYAGTFLYDLIAGSQNMGRSYMVGRNKALEAFPMLRAHNLAGGVVYFDGQQDDTRMNIALVLTAIQHGAVAANHTEVVALNKTPAGGDDKPGRIIGARLRDMLTGEEFDVKAKGVVNATGPFCDALRKMDDPTSADIVSPSSGVHVTFPGYFSPRGMGLLDPATSDGRVIFFLPWQGATIAGTTDVAAKVEPHPLPGEKEIDWILDEVRNYLNADVSVKRTDVLSAWSGLRPLVKDPAARDTQSLVRNHMINVSKSGLLTISGGKWTTYREMAEQTVDKAIEAFDLKPLHNCLTKQVRLIGSHSWSRTMYVRLLQEFGLDTDVALHLSNSYGDRAWSVCSVAKPTGDRYPLHGIRLDPQLPYIEAEVRYATRAEFAVKVADFIARRSRMAFLNTEATIEALPRIVDIMGEELDWSETRKQTEFREGILFLASMGLDLLRVNDLANVSLIEARRWKDTSSPRQLSPALSASPMQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7Z8</accession>
    <name>A8Q7Z8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729624.1">
        <property type="nucleotide sequence ID" value="XM_001729572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7Z8"/>
    <dbReference type="FunCoup" id="A8Q7Z8">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7Z8"/>
    <dbReference type="GeneID" id="5853930"/>
    <dbReference type="KEGG" id="mgl:MGL_3168"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3168"/>
    <dbReference type="InParanoid" id="A8Q7Z8"/>
    <dbReference type="OMA" id="RMNERCH"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="51" mass="5295" checksum="37697979E8687503" modified="2008-01-15" version="1">MDVKCPGCFAITTVFSHAQSVVLCGSCAQVLSQPTGGKARLAVGCSFRPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7Z9</accession>
    <name>A8Q7Z9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729625.1">
        <property type="nucleotide sequence ID" value="XM_001729573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7Z9"/>
    <dbReference type="FunCoup" id="A8Q7Z9">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7Z9"/>
    <dbReference type="GeneID" id="5853931"/>
    <dbReference type="KEGG" id="mgl:MGL_3169"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3169"/>
    <dbReference type="InParanoid" id="A8Q7Z9"/>
    <dbReference type="OMA" id="NRVWIDP"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="5">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="195" mass="23018" checksum="E1A6AF694B2A4966" modified="2008-01-15" version="1">MVNLRVQRRLASSVLGVGKRKIWLDPAEQTDIANANSRANIRKLIKDGQIIQKPVVSHSRERTRNLHHAKRLGRHTGYGKRKGTAEARFPTKVQWMRRQRVLRRLLRKYREAGKIDKHLYHDLYLKSKGNVFKNKRVLMEHIHKAKAEKLRSKHLADQMEARRLRNKTLRERRAQRVAEKRAAILAVEHEGEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q811</accession>
    <name>A8Q811_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3178</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729634.1">
        <property type="nucleotide sequence ID" value="XM_001729582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q811"/>
    <dbReference type="STRING" id="425265.A8Q811"/>
    <dbReference type="GeneID" id="5853940"/>
    <dbReference type="KEGG" id="mgl:MGL_3178"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3178"/>
    <dbReference type="InParanoid" id="A8Q811"/>
    <dbReference type="OMA" id="SHEMNAR"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="230"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="126"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="469" mass="53303" checksum="6A4B31462AB43A21" modified="2008-01-15" version="1">MPPTRTATARRTLHTPSQGASTPGRTRLQVRRARLARPTDEDRSSTPRRVSVPRSAAAAHMHDLCALETQRMQAKQEQERSIQEERLQRARTVDEQLMEERRVAKENRPPPSSWHTYQDYEMKLLCAEYEQTVSQLRAELEDRDTELARLRLAADQHHQAESQLTTSVHEWKTRVAQLEEQLHSRDDRTHELRREADEARALVRNLEMRLIDADALRRRLHNQVQELRGNVRVYARIRPSLQDGAVAEWHFPDAAMLATQMEVRVPTESATGTASVKTHAFTFDHVFPPASTQADVFAEVADLLQSVLDGYHTTIFAYGQTGSGKTHTLEGGAGIDWDHQHAGMNDDPNVGLIPRAMHMLWRVAEAQRIHGWSYTFEASMVEVYLDQVSDLLGDEPGKGKGRAHGKDKCEIKHLPTHTHIEHAVVAPMTRPNDVYALLAQAKKRRQVAATLMNERSSRSHSVFALRSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q818</accession>
    <name>A8Q818_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Eukaryotic membrane protein family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729639.1">
        <property type="nucleotide sequence ID" value="XM_001729587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q818"/>
    <dbReference type="FunCoup" id="A8Q818">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="GeneID" id="5853945"/>
    <dbReference type="KEGG" id="mgl:MGL_3183"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3183"/>
    <dbReference type="InParanoid" id="A8Q818"/>
    <dbReference type="OMA" id="SSHIDEC"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="87696" checksum="8A2053FFB6DCD635" modified="2008-01-15" version="1">MATQEAAKSSESPKKPCTSSTWNEDLEHINREEDIWEDDDDAGDNETFCSPITTEFSRNAWKDENRRSVETPLLQTSFSRRLSDRFQERFQERRRSGTFLAESRIPRLSFDAASPVRTPRTWQNLSWGMAPTPTTPSLPKPSAFPKAALPNKKPSTPAPADDRSPFSHIWEQWSQACHTILVVLGVSAPSEFMEEALRSSSAPMGFVEPNPSTASASYTTNTDAATAGGTPPKASPSLWNQLMEEVLLTSNESMQEFKWERVSNFIAMPVWIEKLMCIGVLVSLNAYLYMVTILPLRFVVSWIRWGYNTLLWFKSRQKLYLNVSNKCDILKGLLVIQTCYILSRIADASKMYHSVRGQDTLKLSVIFSVLEISDRLCSSFGQDVLDTLFSRRTLARRSDGSHAYLRIAGYYTLCLAYIVFHTFVLLYQLVTLNVAINSYDNQLLTLLLSNQFVEIKTTVFKRFEKENLFQLACADIVERFQLCVVLAAIGLRNLLELSGAFAMGGTGAMGPLPTSFELYPYVNVFFRTLNPVLTVLLSEVLVDWLKHAFIAKQNHLRPALYGRFVDVLCRDILPPRSSVALDGHTQRQSSFVDQSPLAIRRLGLAVLPLACVSIRMASQIVSMLLVKDVHTSSDPQRAARATAAASSTAYHQRGWLRRWTEQHSQACMVCLGLVFVWLALVLLKLLLGAYLVSYAMRQYTSWQGREAEEKRNAKGRPPIGETPAEMVHNAQVADMVDKRDDNATKVGLYGQQQASGRGAKKGDISLLDVQRYSLVGSRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q819</accession>
    <name>A8Q819_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729640.1">
        <property type="nucleotide sequence ID" value="XM_001729588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q819"/>
    <dbReference type="GeneID" id="5853946"/>
    <dbReference type="KEGG" id="mgl:MGL_3184"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3184"/>
    <dbReference type="InParanoid" id="A8Q819"/>
    <dbReference type="OMA" id="RTEGMAN"/>
    <dbReference type="OrthoDB" id="2520628at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="316" mass="34540" checksum="25E7AD7BF9BE1DFB" modified="2008-01-15" version="1">MHPETDPLFSSYILATVADWQELLSKTHVHDVYIPVAILSLAHAVRMSHGTRMLCGGGQGRLGLFQSCVLNLIALFAPSSLLALLLGMPSPLLMSPVAICLYTVVHCIMYTTGLGHQLIRLHTHPAGAFWLEIGLACIDSLCRTEGMANVGLAQIQRHPHPVLAQSWTAQVIAGTLLAAGMPLIASAFQLHSPMGIWQLRTPAWIHEPSRLLYADLVGGATVSLLLLVLTSGNLHAKLPWLPRPTRSMARWLALSHKPDIHRSTHLPYLSAREAKAVCTAVLFVCLLVPIIHRRLVKQRGSVARQQEGARTKKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8B6</accession>
    <name>A8Q8B6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729697.1">
        <property type="nucleotide sequence ID" value="XM_001729645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8B6"/>
    <dbReference type="STRING" id="425265.A8Q8B6"/>
    <dbReference type="GeneID" id="5854003"/>
    <dbReference type="KEGG" id="mgl:MGL_3241"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3241"/>
    <dbReference type="InParanoid" id="A8Q8B6"/>
    <dbReference type="OMA" id="SHARTIK"/>
    <dbReference type="OrthoDB" id="2576541at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727258" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="57983" checksum="5706FDAB9032DC65" modified="2008-01-15" version="1">MRAALGVWAVLGCTSVGSIYALQQHSHALSEEVSAPTVSSEFPDPLHHHYHQYHHRHIRVYPHASSSVWRLRRLHQNANRDWWEPDNILAQGDSLLSSLVGGEFTTINKDSSAPGSSPTVHPNNHLLSSHEFTTINKNSRASPTDEASSSAASKVASQTSSSGDDEDKETSSQVPTKSSTSRSVASSTQTQEDSSTPGAVQSTSSTTMKRSSRSSSPTSSSLSSLSSSSLSSSSSTGNGDNVERTSATPSASSQESLASSQESSVRSPSSRASSAPMPTTSDADDESAKAQPSSSSGTPGSQSPMDPSQHMSNADSDGHDHTGLIAGVSTAGGVVVAALLLFMLYWLWKSRKSREEISYPDVTHDSAISSSPLPARQTGGAGFEMEHDRVYDDDVFSHARTIKPMDSFGDESMMQARSGGVPESYVNVPDEVSRPPSYEQQPSTALTQMAPVRHPPSLIPSGPPLEDVQPSLPPQVDSTVPAKSGTSQHVPISMPEAVTEEQGRHASATCSASTVPRINTLLSVSCIPTRLSSRTTMHPAPRELYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8V6</accession>
    <name>A8Q8V6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729308.1">
        <property type="nucleotide sequence ID" value="XM_001729256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8V6"/>
    <dbReference type="STRING" id="425265.A8Q8V6"/>
    <dbReference type="GeneID" id="5853620"/>
    <dbReference type="KEGG" id="mgl:MGL_3343"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3343"/>
    <dbReference type="InParanoid" id="A8Q8V6"/>
    <dbReference type="OMA" id="EDTYPLM"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="3">
        <location>
            <begin position="456"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="915"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="957"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="969"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1166" mass="120945" checksum="555B2D2AD531EB02" modified="2008-01-15" version="1">MNIQSESSANEPTTPVAVKRSHSPDQVALYDQAAEHAKRARIHSRPHFADAYLECLSSSELIRIIRQIEQLLQDTPHAADVYALIYPNNIEERVTASRRELAASSIQTDHSLRTSSEPPHSFPSSSAHISPPLSSAPPLLSSHVPHVPSPLHADTTTHSTTDKEPLHQPPGLTVPPDSSEQTSTPTIQVSASVAPPSPPPHTAAAPSASFLTDSSVISLGEPPAGTASRLYTPMIPASTTDLGTSMTSTSEPFISSTSTTTNVTEPESVTNNGNISSRVAAILESIQNTNSSGPMLGLQGQPLAPSKQGGSGSGMTSGLSSLLSNSFPNANHRMPANSALSRLLEQTTPDPGGISSPASAIPPATSTATTASSLPSASSLLSSLTTRPGFSTGITATGTGPSALDYTSLSHATTQSNAAATSSGLTSSFTPTYGIHDPHTTDANDSTREPPRITSTLPSYEDMIIEGLQAIGDVNGTPPRMLFHWMEDTYPLMKNFRPSASQALQKAFKRGRLHKAGSLYRINPHWDGSNAGRKPTRRPQIGKDHPMMVNGPKGPAPASPFKARAQFEGAAAYRQSSVHLNRHRGLRHPSTLRPGPKPYGQPGAAPLDNPASSIFQNGAAAAALLLAHQQRSRDHNGTVPLTSQDLTPTLTSLVRQLRASQGTALQGADGSTQSTSSLSSILASALLKHAQRPSDGSAAISDPSSLTPMTNSLTSTSSPVLQSLSRLLGSARSGTGAPGSGADAGSIDHGTGLGAGSAPTLGMSTGPDPNLGLTSSAEPVPEHKSYLPFSTSSVPSPAPLPASGPGSLSASIETLVRQATRAATHQVSSDDSLTISDPANEPIEPAPSATQSDLDAAVSETLQAAFQEIGPQHKPASTDVVPDASMQDLDTSELDGINLEDYSDALRTLTAALAGTHGDDGDDVDMSGREGQSHGHNGEDDDEEAQRLADEKAIADAEADLSDAEGGDSDGHESVPDHDRPYESVGSNRMESLLRSYGIDVSTEAIQHLTETLRDPNMSVSDLTDNKAMQSGATGASTTCASVSSASEEPTSSSTNTHVPQPSASSANDRHVQPPPSDSAPSLKPEESFSHHESTVPRQDQSIATGLKEEAHTSNSAAPTTTSATSASDSPTMPLLDPEASDEAHNQSIQSQLEALIASLAADSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8W6</accession>
    <name>A8Q8W6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3353</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729318.1">
        <property type="nucleotide sequence ID" value="XM_001729266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8W6"/>
    <dbReference type="FunCoup" id="A8Q8W6">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8W6"/>
    <dbReference type="GeneID" id="5853625"/>
    <dbReference type="KEGG" id="mgl:MGL_3353"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3353"/>
    <dbReference type="InParanoid" id="A8Q8W6"/>
    <dbReference type="OMA" id="GYTPCFR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="133"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="278"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="349"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="440" mass="50575" checksum="07E02E53185CB8F2" modified="2008-01-15" version="1">MIDLQLLQVEKGGNPDLVRESQRKRNAPVELVDEVLSMYKHWEVNATQKAITAKKKAKEDADAELAKKKELDAKIIEFKPQVAEAERAMRAKAVTIGNIVGDKVPVSNTEDDNLTVRTWHPEGPNAQFEKRIDFVSHHEVMYRLELFDTERGAKISGHRGFFLTGDGVDLNQALINYGLDFLRKKNYKKMMTPFMMRREHMAKTAQLEQFDEELYKVTGDEDDKYLIATSEQPISAFHSNEWFDRPAEQLPIKYAGYSTCFRKEAGSHGKDTWGIFRVHQFEKIEQFCITDPASSWEMLDHMLANSEEFYQSLQIPYRVVAIVSGALNNAAAMKYDLEAWFPFQGEHKELVSCSNCTDYQSRRLEVRCGMKKQGDTKKQYCHMLNGTLCATERALCCLVENWQTSEGLRIPPVLQPYMQGRDFLPFTKDLPKGSTSQKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8X4</accession>
    <name>A8Q8X4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729326.1">
        <property type="nucleotide sequence ID" value="XM_001729274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8X4"/>
    <dbReference type="STRING" id="425265.A8Q8X4"/>
    <dbReference type="GeneID" id="5853633"/>
    <dbReference type="KEGG" id="mgl:MGL_3361"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3361"/>
    <dbReference type="InParanoid" id="A8Q8X4"/>
    <dbReference type="OMA" id="CSGACLN"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="237"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="516"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="581" mass="61517" checksum="907CC88C8A85A18D" modified="2008-01-15" version="1">MGPSTPTRAKGSTAALTRGLGMMSLDSPLSDRPTNLRSRFHASPIRHPSIKSARTLGPAGGGVVSGIAAGGRRDKEDCLLVHSMDGPDARGVVAKDWDGPDGTVPRRRGSTMVSRGDRYIPNRELLRRGTTPFLEDSAGDALSHHNSSSSAGSDSLASDAAAAAAAAELDSPPALEGACQVDLGQRILSFSAAPPSASSSSAKDLHTRYASKPKSTLPSSLVAAGRRRIPTAPERVLDAPAIVPDFYVNLLHWSSQNVIAIALQSAVHTWNSETGEANFLLDLEEESERVGGGGLVTSLRWDAHGNILAVGTDRGYTQIWDVARGARLRTLRPSADGGADASAVNAAAWAVDGTLSVGYASGLIREHDVRQRSSETRSLEHAHAAQVCGLSWRDDSALLASGGNDNVVKVWDRRTNVAKMRKENHRAAVKALAWSPHNSSLLATGGGSADRCIHFWNTTQNTRVQTIQTSAQVTSLQWAPHYRELVSSHGVGTSESEAGALCVWAHPSGQKIADVPGAHDGRVLHTSLSPDGQTLATVGSDESLKFWRVFEQAQDVSKAQRSVLTSYKGLARSAPPTRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9P5</accession>
    <name>A8Q9P5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729493.1">
        <property type="nucleotide sequence ID" value="XM_001729441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9P5"/>
    <dbReference type="STRING" id="425265.A8Q9P5"/>
    <dbReference type="GeneID" id="5853800"/>
    <dbReference type="KEGG" id="mgl:MGL_3528"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3528"/>
    <dbReference type="InParanoid" id="A8Q9P5"/>
    <dbReference type="OMA" id="MGFEMFC"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="39"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="422" mass="46836" checksum="B9593AC918CB99BB" modified="2008-01-15" version="1">MTMSSSAPSLDKLWSEIPKAPGDSILALSSGYANDASEKKANLGVGAYRDEQGKPWVLPAVRMAREELLNDPNWNHEYLPIPGFAPFVSSAAKLMFGDDAACIKENRVVSNQTISGSGANHLGAEFLHDFYPFPSGKKQIYVSDPSWPNHFAILGAANLETVKYTYYNPQTRSLDFDGMYKELSQAEDGSVVLLHACAHNPTGVDPTEEQWTKLAELFASKKLFAFFDSAYQGFASGDPAKDAFAVRLFASRGDIAMLVCQSFAKNAGLYGERVGALHVMTGSSKQAEAVQSQLNIITRRENSTMPAFGARIVAKILTEPKLRAEWDRNITTMSHRIIGMREKLYDLLTQKFQTPGTWDHIKTQTGMFSYLGLNESQCDRLVKEGHIYLMRTGRVSMSGFNPANVEYIAMWIDKVVRERSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9T4</accession>
    <name>A8Q9T4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729523.1">
        <property type="nucleotide sequence ID" value="XM_001729471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9T4"/>
    <dbReference type="FunCoup" id="A8Q9T4">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9T4"/>
    <dbReference type="GeneID" id="5853830"/>
    <dbReference type="KEGG" id="mgl:MGL_3558"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3558"/>
    <dbReference type="InParanoid" id="A8Q9T4"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15072" checksum="D4CD90ABD03FE45C" modified="2008-01-15" version="1">MCARLSIKSRETNINCRDDYDAAAAAELKRKRTFRKFSYRGVDLDDLLDMSNEDFVKLVHARARRRFSRGLKRRPMALIKKLRKAKKEAQPNEKPAVVRTHMRDMIVVPEMIGSMIGVYNGKVCSHTDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9T5</accession>
    <name>A8Q9T5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="16">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_3559</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="16"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729524.1">
        <property type="nucleotide sequence ID" value="XM_001729472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9T5"/>
    <dbReference type="FunCoup" id="A8Q9T5">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9T5"/>
    <dbReference type="GeneID" id="5853831"/>
    <dbReference type="KEGG" id="mgl:MGL_3559"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3559"/>
    <dbReference type="InParanoid" id="A8Q9T5"/>
    <dbReference type="OMA" id="ELGDAMW"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000005">
        <property type="entry name" value="crossover junction endonuclease MUS81 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="18">
        <location>
            <begin position="355"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="156"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP42310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="657" mass="72286" checksum="32259BADCBA39986" modified="2008-01-15" version="1">MAALCASSSAAELPPPQKKSTRPRKTKAYVPEPRSGAHGILVAMYLKAHEDHDKDAQLGKSELIARAQPYCDNDYSVPGCGTSSATPASLLRRGMPSGSQSLAAPRKSFATAWSSMKVLINKGYVYRSGNPALYSLSEQGLEIASILATAEGFSPTIQSRASPPRASSEHVAAPLSSSPSTSSAQLPSSPTPSPLHPAAVMPLHSPSRTTNVAPLPLHHAAPVLTASRLDSSPSPEVIQCDPQPSTQRSSRVTTCVPQLYLPPRTNLSQASIPGAAREPSPGDTINLVDSSDNTSFDAGSDGIQIIDTPPRSQRLNISLIESSPIVISSSPHAISQAHDAVVGCYILPPESYTIHMVVDHREVRSRTSTFMDAGQQRITFEGALTQRGVPCELRALELGDILWVARPKRDLPPDKKKAWTYVQEVVLDTVVERKRLDDLASSIFDGRWHDQKQRLRHAGIGQVIYLIEDIHVPHLMQRHGAQIQTALSSTQVIDGFFVHRTANNQGTVDFLVTLHEAVMDMYKDTPLYVLREETIAREHYDQQQRTMRAEYPGIRFHTSFHTYQQLHAKTSTASTIEATWIRMLLCVRGVSADKAQEIVRHFPTPQHLLRAYSRCPSQLDAQRLLSTTIDATTRLTRRRIGRVLSERIWHILDAPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9Y6</accession>
    <name>A8Q9Y6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hypothetical acid sphingomyelinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3568</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729101.1">
        <property type="nucleotide sequence ID" value="XM_001729049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9Y6"/>
    <dbReference type="STRING" id="425265.A8Q9Y6"/>
    <dbReference type="GeneID" id="5853408"/>
    <dbReference type="KEGG" id="mgl:MGL_3568"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3568"/>
    <dbReference type="InParanoid" id="A8Q9Y6"/>
    <dbReference type="OMA" id="MFGRTCG"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728144" evidence="3">
        <location>
            <begin position="22"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="261"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="742" mass="82654" checksum="45F0990935808C0D" modified="2008-01-15" version="1">MVLTVYFVYITLFICALDAHAAHSSQPKQSWSLHGQGSPVYTASKLFPTDKFYSMYFSPKAQEAEPRPVVTKIGGKTFADSLNDPARMPSEPPSNSGVIPAPSSTSLPFNLKDQTHQKVSKVIRNSSMSKCDRCKNALKLGQSLAHVQPESVPNILIELCKEFQYKQFGRNPDVNKTCELSYTQGGQGGVFTQVLSYADLSDSSSDPDLICAQLFYNFCPMPEPKTLSDSFLNDWFHGQREESIKIKQRSKKVGKPASSDLRVLWTSDIHVDGRYAVGSEAKCTYRYCCHSNSFNVESFNSSGYITGNTSVPSKNITLAAPYWGYEGCDAPWSLVASAFQAMEDLGGKDGYDIALYTGDLVAHGQTWEESQELVQYSESALFDMMHRYLRNTTVISAIGNHDTSPTEYAAPNNLPDGRGNQFSWDWDYVSKLWNSEGWVNDTEQTQIRTHYGGYSISPRQGLRVISFNTDFWYRGNGFAFLHTSNPDFSGVLRWVTDELQAAEDAYERVWIIGHVLPGWDGYSSMDLPTNLFYQIVTRYQSTIAHMFFAHSHEDTFSVFYHNTNGNSSSASLRTQDAVGIALHSPSVTPLTNMNPGIRILQVNPETYEIMNYDQFYTPLQNVQNQTETAKGLVWYHLYSAREAYGNFSAAKAAGSYHAPVQLNDDGTWPAFVPLNASFWASISDEVLARPELATQFQIFQGRNSPLSPPCSNKACAKAKACFMRAGSFALGRACGSSYSTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA14</accession>
    <name>A8QA14_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729113.1">
        <property type="nucleotide sequence ID" value="XM_001729061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA14"/>
    <dbReference type="FunCoup" id="A8QA14">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA14"/>
    <dbReference type="GeneID" id="5853419"/>
    <dbReference type="KEGG" id="mgl:MGL_3580"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3580"/>
    <dbReference type="InParanoid" id="A8QA14"/>
    <dbReference type="OMA" id="HKCLAQC"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="588" mass="66479" checksum="DA0CC027718441B3" modified="2008-01-15" version="1">MSTQRSSAIATHKAGIFGTKTNAWDEFELPEMVSEILKVPMFSVSSESIVTVRTPRQFYGLLKNKIMQAKRRIFISTLYIGREERELAIYLGQALARQPQLQLTILMDAMRATRESPSSVSSASLLSHLAAMFPNQVDIRLYATPALRPKSLKARLIGKRFNEGLGLQHMKVYGFDDDVIISGANLSRDYFIRRMDRYMLIQNHESIANYLHSLILLISRFSYELQYKGDKQLINFCREHIFDMDDFSKEHMALSQSSFHLGWDGGDGLLLSEDTDGTISAAGLWPSSETFPEKNWKDVASKTLRDFTIRWHERVKAERSHRNGDTRLIPLLQMGQLSITQETDMIPLLTDYLSALCSRIKPMQTNLARPFTTVDLTSGYFTLSGTYRSLVLSDKIHSLGTTPSSVPVVFRLVAASPEANGFYGSKGLSSRIPAAYTFLEKEFWKQVVAKSLHEPLKPDGGSSIFDLTDPVSQGSLAPVELREWSKYGWTYHQKGIWISLPSHNNQALQPSTTLIGSSNFGSRSEKLDLECTLFMTTKATPLKAVLAEEVLEMRECARELMNSKTFDSPERKVDIVTRFLTKLVKYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA29</accession>
    <name>A8QA29_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729123.1">
        <property type="nucleotide sequence ID" value="XM_001729071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA29"/>
    <dbReference type="FunCoup" id="A8QA29">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA29"/>
    <dbReference type="GeneID" id="5853429"/>
    <dbReference type="KEGG" id="mgl:MGL_3590"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3590"/>
    <dbReference type="InParanoid" id="A8QA29"/>
    <dbReference type="OMA" id="RCHRFIY"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9016" checksum="6049A0168B8DD628" modified="2008-01-15" version="1">MPKQVTDIKQFLAIASRKDAKSARVKKTVLANRNVQTKFKVRCARYLYTLVVNDADKAEKLKQSLLPGLKVVEVGSKQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAE0</accession>
    <name>A8QAE0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_3699</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729232.1">
        <property type="nucleotide sequence ID" value="XM_001729180.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8QAE0">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAE0"/>
    <dbReference type="GeneID" id="5853538"/>
    <dbReference type="KEGG" id="mgl:MGL_3699"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3699"/>
    <dbReference type="InParanoid" id="A8QAE0"/>
    <dbReference type="OMA" id="TLFIAWN"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000153">
        <property type="entry name" value="High-affinity cell membrane calcium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="557"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="608"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="953"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="988"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1033"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1078"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1207"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1287"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1320"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1357"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1454"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="1498"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1557"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1835"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1586"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1835"/>
            <end position="1855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP42018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1916" mass="218638" checksum="02B3E9F1498909FD" modified="2008-01-15" version="1">MLFGPRHPWRVFLAKVLSSWWVEPLILVFIFINLVVLIVSSSRDVKLAPRTENSFVKSEEILLLLVFVAYTIEMAARIIVSGLIIDPPPLDEAAAQEAYPTADQEYSNTYDTLYHLYTSTLEAVYRFLHPYSKVQQERAEAKLASLHPTDGMAPLDDLFISKSEDKHELHEEHAHWWDALYYNVVSICLHLSRTITNDPKQLCEHAYLRQSWNRVDALAIVCYWVAVVLELTGVELTSSHHIFVFRALSVLRCARLLGLWEGTETILRSLKRVAPLLFRVLSFLVFAMVLFAVIGVQSFEGSYRRRCVWIGDYNRSPGQNYTLEQICGGSVDIRNRSNTIGHVQYNGDLDSARSPKGFICPYGQLCVEQESNPYNNVQSFDDVFHSLLEVVVIVSLNGWSDVMYDMVDADYYTAIIFFIIGIILLNFWLANLFVAVISHSFASLSAQTERSAFAAQGFRKNQADAPEPQGPRRRRHRFVVWYKRVRRYTQYFWLSLIIVSVAVQGSKASYEFPEQKKWREDVERYLVIPFDLEIIVRFVVDCIIGGPSLFFQQKRNVLDLFLALITTIIQIPAISYSSWYPWLTFFQLLRFYRVIAAIPRMKGLLMRVVGSMSALFNMIAFLIMTIFLAALVSIQLFRGDIELDAEDGVTENFTWKQLFNGFLGVYQIFSSEDWKESMLNVVSDTKKWKQGVIAAIFIVGWFFFANLILLQLFIAVINENFRVAEGDKYKQQMENYLRRSEPAQASLLARIMQRLSPFRAPPEPNSMPHRLEGPALGDARQHADTSQARHVDDRPLRSMFMQLVTPDHAGLAFGTLQRVLRLDKPHEHARLQALRSQAEGGQASQTMDELEDMINERQDVRMLGPEHVRTMRTDLGLVNQEEGQEFLNNYVRRNENDPRIRIARLMAEHPSYDRSWFVFSNRNPVRRFCQSLTPTSHGERVFGRPVSKFRNHIFQAIVFGAIAGSVILAGIVTPAYRKKYLAEHRAVFYAWYAVIEVSLSLIFVLEFFVKTIADGFMFTPNAYLQNVWNLLDMFVLISLLINVISELIVPGGVSHFTRALKAFRALRLINLSSLMRDTFHAVMIAGAGYILDASILALLYIIPYAVWGQNLFAGLLYSCTDSSDNIVSKLDCHGEYMSQPLAWSYLAPRAWSNPSEGSMYSFDDFKSALLILFEVVSLEGWVDVMRQAMSIIGRDLQPRPDASQYNAIFFLVYNLVGAVSVLALFVSVIIENFQRYSGAAYLTTEQRQWLDMKRQLQRQAASRRPANPPSNAFVRWCYQASTHKRGWWSRAMSVLYLVVLVLLMSQSFSDTWPTEQARSIVYSVLGFVFACDLLIRLIGLGVSSFRRSYWNCDSLDLLFKTAVGSVPAIIALFLLWLTMFLVWGIMLVEVFGLTRWGPNESHAKNFSSLWQTLIFLSMTSTGEGWNQYMHDYAVQPPLCTPSKNYLYSDCGSTAWAYFLFISWNIISMFIFLNMFTGTVVENFSYVYHLQGSSALSREQMRIYKDVWNQFDPQGLGYISQQQIIPFLARLTGMFEVSLYPPELRIHALLDRSRVNSPRYGHSLSSPSSSSKIWGRRSPRSPRSPRSPRSLRSRSPLSTRSQPSQSWHSPHRAPPSPRSPGSLPSHLSDRLNALQRNASSTSLSDHSPFDDDLVPSVAPRIESGIDLNELSDALNSVNIQDLRMRRQRLNRMYYEAKMSDKGKGVSFSSMLFILAYHKMCGAPVNMEVSEFIERREMMSKIDARINLERVRGLLRGVYLRRRFLAERAERERQSVMHLVSSNKEGGFPSITVERPMSEAQHESSDAGMALHLHNDQDPFGTHAGALSILIPQSMSGYTSSDDVESANASDVQLSPGSGSGPRRRLSFQNQDENPFVEQHSRGTHASSRLQPPFEMDTWTQVLHRLSSDTLDSDGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAG1</accession>
    <name>A8QAG1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729253.1">
        <property type="nucleotide sequence ID" value="XM_001729201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAG1"/>
    <dbReference type="FunCoup" id="A8QAG1">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAG1"/>
    <dbReference type="GeneID" id="5853559"/>
    <dbReference type="KEGG" id="mgl:MGL_3720"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3720"/>
    <dbReference type="InParanoid" id="A8QAG1"/>
    <dbReference type="OMA" id="LPYWFAY"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="591" mass="66400" checksum="07CE66997F3684D2" modified="2008-01-15" version="1">MRDEKAEVQATTSALEERPSLSHRKHGPTLKRAASFDQDSGEASLSDDASTRSIVDSLDLAPSLPYWFAYVRARMAEYAHDIEQLVHANQAHKLSILVPLEHMETRLSAAHDAMVRMMRDWSLAHGGAEWFDKLSSLSEVKGHVYTLMTEWERRVHTLHPTLFDSVSAAEMKQIPRRWASRMPATAAYLSEEVQRSLAAVRGHIQNVTLPSLRESSSSWAHDAQSMLPQHIPSLHDLPQHVEEALQTIGRCGREAGAQFVHAVHDVEDALYHAALRLAKNGRELIPYQSLPVLWRNNDFITTGYRFIPKDQWHNLILSAFRVHNETGNIHTHLSGLLLVSFLFWLTGSVDSDTTTTADRWMMIMYLLAAAKCLLCSISWHVMAGCADIQWFMCFACIDYTGISWLVAASLETLVFNGFYCQPGLIAIYTIGVIGVGIAMSVLPWSAWFNDPSYRSIRIAMFIGMACMGFVPFVHGAVLHGFGPMVRFYGPVVPSLLSYIAGVVVYGLRWPERVAPGKFDIVGHSHQLWHLAIVLAIYLHYKAVLSFEKHRYEFSCSAGYTPSPTLEQLFILMRRVSQYIYNAGAKDGPLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB58</accession>
    <name>A8QB58_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_3884</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728890.1">
        <property type="nucleotide sequence ID" value="XM_001728838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB58"/>
    <dbReference type="STRING" id="425265.A8QB58"/>
    <dbReference type="GeneID" id="5853198"/>
    <dbReference type="KEGG" id="mgl:MGL_3884"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3884"/>
    <dbReference type="InParanoid" id="A8QB58"/>
    <dbReference type="OMA" id="FWSMEDS"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="203"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="406"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="720"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP41676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="841" mass="93683" checksum="5C7B1E57839E449A" modified="2008-01-15" version="1">MASGSIPSPRWSSMGLEELCHRYTHLKQVRLHAMEKRASIVCGDGLFNDSIDYLKIEEQLCASRMSAIEDELKSRGQPVNSPLATPQLTSSPSMLLSSSQPQTVPSQHEPESVDLLDEDDIDDDDDFDMLIPDEDLVQMEIPTSTPTTTGAGNKAPPSASLSEQSPIKPTSSTLFYPWDDQVRHSLHHIFLLKEFRADQLEAINATLSGRDVFCLMPTGGGKSLCYQLPSTITLGRTNGLTVVVSPLLALIHNQVKSLLRKDVPAMAITGDMSDADRRYASSELLRKNINVRLLYVTPEFISKSRLASQLLQHLYQTHQLARFVIDEAHCVDQWGHDFRPDYVRLNLLRKTYPTVPIMALTATARIDTVQSIQQSLGMRNALVLRQSFNRPNLTYKVCPKMRGSATLETIAAIIQKHHANECGIIYCLSRRDCENVSTDLGNKYGIQARHFHAGLNIEDKLRIQEGWEAGTFKVIVATIAFGMGIDKADVRFVIHHSMPKSLEGYYQETGRAGRDGKWSDCILFWSMEDSRKLEAMIDESPDASAEQKRLQIKSLYQVRTFCESLTECRRTNILKYFGEKFDPKLCHASCDNCQRSPAHCVDMTTSAKDFANMVKLITQQRQQRNSPPRFTRIHFVNVFRGSQRKEVKDHGHHHNLYHGSGAHYSDDQVRRLVDHLLNQKVLAEYSSKTRFQRFANYYLQLGPNASKLLQGHLSVRVDMPSNPSVGAASTSRRSNTSAALHGPTSVRAESPSSSDDMDLTFISLSPHRMKTVAAPAAAHQSVSTAPSSGVLAGKNGTAASITTSPARPLADRTNRLATGPVATPHVHIAAMPLRKPPVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBF5</accession>
    <name>A8QBF5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728913.1">
        <property type="nucleotide sequence ID" value="XM_001728861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBF5"/>
    <dbReference type="GeneID" id="5853219"/>
    <dbReference type="KEGG" id="mgl:MGL_3907"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3907"/>
    <dbReference type="InParanoid" id="A8QBF5"/>
    <dbReference type="OMA" id="GWEWIPD"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF105">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="426" mass="47768" checksum="A549515A00379096" modified="2008-01-15" version="1">MDVHVVYNQHAGHHKAKKLLDAVVRPRLEAWCHAHRETRCMLHFHETDAQTGAIGTGRALTQQAIDRASVYVVLGGDGTVHELLQGMYLERRVFLADHGVSLVIVPVGTGNALYHSHFGPDISPSRDPTWRLRSLEAFLRSAPAGRASCALTVMRANPGSRLACVVVSHALHTAILRDSEALRSNHPGLERFQMAAEKNATVWCDAVLTLLPQEQAPVTVYDPTTRIFRAVNEKRVNQSEMRMAEEDATLSYECMPDGRVRLRGPFIYMNAMTVDRLEPTFVPAPFASVYAPEPLRRPSDAMDVVVMRPMQRRPTGSRCVSRDEEAVAYASDVLYPALFQGMYKQGRHVDMTYTDHHEAHHVHEGNRPFRVTHSRPVVEYFRAAGYEWTPLPGDEQARSMCVDGTVVNVDHANVQVLRSAHVYLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBS9</accession>
    <name>A8QBS9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728944.1">
        <property type="nucleotide sequence ID" value="XM_001728892.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8QBS9">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBS9"/>
    <dbReference type="GeneID" id="5853250"/>
    <dbReference type="KEGG" id="mgl:MGL_3938"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3938"/>
    <dbReference type="InParanoid" id="A8QBS9"/>
    <dbReference type="OMA" id="FEFVLRY"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="129"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="247"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="337"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="631"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1231"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1102"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1176"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1250"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1320" mass="145849" checksum="981CC3732C226F99" modified="2008-01-15" version="1">MRSPASFSSSANGMAPGPCSPAEVNRRDYFGRTVLHLLSASDDPAANDYFQLLLSHPSVNVNMQDRESGWTALHRALYAGNLHMALVLLERPDIDCHVRDWEGLTPFDLYNSTIEGTYPNDQNIASDGGDLFVWGTNRNYTLGLSRDNDSALPERVKLQAREPYEAGVAGSRFNRPYVRDISMSRWHTVVATNERRKNVYVCGIGSQARLGRMAQTQTRFEPLRDFSETAQTVVASSDHTLIVTTQGTVYSFGSNRMGQLGFLLEEGQGILSSSSGTKRSAATSHTGCTSLQGTIIGANGVELDLQVTPRRVLGPLKREVVLGAAASRIHSVAYTADALYTWGTNNGQLGYDRHSAPLQVQPRRVTLISVPVRQVAATEFATACLLETWDVTVLHGDAHYRIPFPTPRITSDMGMFRPRQAQPKPTIRKITCSGTTFAALSNLGDVFTFHIEHPSTTGPKVVLPRPQLAWSVRRKFSAVRDVAIGSDGALLLCTADGHVYARSQKLDVKGKTRIPKFQAIPFLQRIVRVVANETGSFAALQVPWQFPCIPVRGRSLEEDLLDLALPRASIPASLDTDPVDVSDDDSDEHDPASSQMRRYAVQARTLLDFIAESRAHYSMPVDMPSCAPRGCDAALIVEHGSHWIPVHRVLLAIRIPVLSHVIWNGGGESFSHDVRVCLEEGTCMVYLDAMSYVSAMFLVYYLYTDDVLPVWGVSLGFMLASQCRDQGIDITHIRSELDVWAKKLGLDALFDLLQSGLVKPPRKTLHGGLAQLFDRVLTRKGGPGADIVLHLSDADVVCHSLFLRRSPMIEALLDWYHMRGDQGKQVHVDMKHMAWAVVRVGLAFLYTDAGVSAFEGCDENKTPDEFIDFVLDVLQLADEWLLDKLQLVTFSFLSPRVKPTNVAALLTDALRLNAPAFSHACMDYVACNLETLLELGSLSLLGANERMHLTQYIQAQQDRVLHRTFAKDHLLALYIKHQDYMADLDLPKPSLNLACLKVPKRYKSPRIVPVDDAPIPRSQRHNQDGVIAGTSAVPPNAAPGDESMLFAMDDVTPERTPEPVWRTVNAKPLRTPRRSLDPEPTELPGTHTSQTPYLGASDEPSRTLSSSPSSVPSPMTPKAQSTVLQMPLSARVSQKERKKQQQQQRQQQPSPAVKVDSPPVWRPGSLRSRSDVWGLSPSGSSTATTTSTPSTTAAAVAAAKATGTATGVGAKSSSIPPAMSFAQIQAQQQAAISQAREQQDRPKSFAQILDEERTMQERERRERQEAEAFERWFEEESRRVQQEARRSQSRRQDTRRGARSNNRGRRRGKPNPATARIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC85</accession>
    <name>A8QC85_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728814.1">
        <property type="nucleotide sequence ID" value="XM_001728762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC85"/>
    <dbReference type="STRING" id="425265.A8QC85"/>
    <dbReference type="GeneID" id="5853120"/>
    <dbReference type="KEGG" id="mgl:MGL_3981"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3981"/>
    <dbReference type="InParanoid" id="A8QC85"/>
    <dbReference type="OMA" id="MTANEHA"/>
    <dbReference type="OrthoDB" id="1872003at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="55"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="244" mass="26132" checksum="C9DBF687412A0B63" modified="2008-01-15" version="1">MERHDDHERNDANLSVKVTNASLDTARSVLLREAQALHKLAEKLQQNDQAMRFAIELVLGRSSTLASGKIVTVGVGKSGFVAQKLAATLTALGTQAVFLHPIEALHGDIGILQAECDTVLALSYSGESLEVLALMQLPQVQRCAKIVMTANEHAQLVRLADAWLDCGCHDPMLKGTDVVLQGGFHTSSIEGWPEIPVPTTSAISMMAIGDAFCVALSHAKGVQRQTFHANHPGGNLGKVLLNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCR4</accession>
    <name>A8QCR4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_4038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728871.1">
        <property type="nucleotide sequence ID" value="XM_001728819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCR4"/>
    <dbReference type="FunCoup" id="A8QCR4">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCR4"/>
    <dbReference type="GeneID" id="5853177"/>
    <dbReference type="KEGG" id="mgl:MGL_4038"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4038"/>
    <dbReference type="InParanoid" id="A8QCR4"/>
    <dbReference type="OMA" id="ALYGTWR"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="273"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="373" mass="41091" checksum="3BEC65889614744B" modified="2008-01-15" version="1">MAARPTVNVRGIDGAASGSLPLPAVFNAPIRPDVVQAIHSNLAKNKRQPYAVASNAGHQTSAESWGTGRAVARIPRVGGGGTHRSGQAAFGNMARGGHMFAPTRVWRRWFIKTNQTQRRYATASALAATALPALVLARGHRVEEIEEVPLIVSNEIESFTKTKQAIAALKALNAYDDVIKVSNSRKIRAGIGKLRNRRHTQRRGPLVIYNQDNGIVKAFRNLPGVEIASVHSLNLLQLAPGGHLGRFVIWTEDAFKQLDKIFGTYESASEVKKGFHLPSAKITMPDVTRLINSDEIQSVVRPAGPKQTKRPFTQKKNPLRNRGVLFRLNPYAQASIRRKLREQAQRRAGKLKKNTKTPRTATSEAFFEQLFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD28</accession>
    <name>A8QD28_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_4096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728761.1">
        <property type="nucleotide sequence ID" value="XM_001728709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD28"/>
    <dbReference type="FunCoup" id="A8QD28">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="5853030"/>
    <dbReference type="KEGG" id="mgl:MGL_4096"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4096"/>
    <dbReference type="InParanoid" id="A8QD28"/>
    <dbReference type="OMA" id="VIFTMPE"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="249"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="713" mass="78464" checksum="EA141797B6303892" modified="2008-01-15" version="1">MDRQLAASIQSHDSDSFYEAEDGTANDKSQVPNVRVIDLPDPARPSPTAAPPHHSGAPPISMMPYMNNQTATPDQPYAGESLPAAAPEVAPTEVPPDVVALQPPPAVHASDSQLHPSWLGDLPRPEHTERRRSSHFIPHDLRRSLSRVSLYQPGTPRPQGPHTNLRMSRQDFESGPWGYEGQRGGMEFPETAGIEIDETNPSKEAGESSSPGDGEAKYEEETKHIIVKWDGKDDREHVLNLNFYYRCYLTLLAGSLTLCTAFASSVPSGIVTEMIVEFNTSLNVVKASVFLFVGSFCVAPLLWAPLSEMFGRKIIFIISFAGFTAFNIGCAFAPNIAAMIVMRILAGAFGSSSMSNAPSMIATLFPLKYLMIGIVFFALAPIAGPCVGPIVSGYISVSNGHFMKKALGMGLSQAAAQDYANDHANWRWVFRVCAILSGVLLLLVIFTMPETLDGKRLQMKARRLRQETGDDRYVAPIELRKINWLQLAGKTVGKPVKMLFTEPMLMLVTIYISFIYGVLYLLFVAYPIVFIRDHNMNNGEEGLAFLGFFCGCALSAAYCLFVDQPRYVKSMEKLKVPLLSPERRLETCMIGSPCLVIALFWFAWTAFPSISAWSTIVAGGVFGIGLFFIFLSLMTYVTEVYLMNSASAIAANTVVRSAFGAGFPMFGQQMYEKLNPRWATTVLAFIALVMMPIPFVFYKFGSKLRAMSKNARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD54</accession>
    <name>A8QD54_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">threonine synthase</fullName>
            <ecNumber evidence="4">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_4122</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728787.1">
        <property type="nucleotide sequence ID" value="XM_001728735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD54"/>
    <dbReference type="FunCoup" id="A8QD54">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD54"/>
    <dbReference type="GeneID" id="5853084"/>
    <dbReference type="KEGG" id="mgl:MGL_4122"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4122"/>
    <dbReference type="InParanoid" id="A8QD54"/>
    <dbReference type="OMA" id="NFERYLY"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000024">
        <property type="entry name" value="Probable threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="10">
        <location>
            <begin position="90"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="532" mass="59124" checksum="EE21FF1DC3BDD363" modified="2008-01-15" version="1">MKYLSTRGGHERLTFEEAVLQGLAPNGGLYVPAEMPTLPDDWQTAWASLSFVELSFQIVSLFVPTTAEEGGIPPDDLRELITKSYATFRHEDVTPLRRVSEHEWCLELWHGPTFAFKDVALQLLGNLFEYFLARRNATASNANRADRAPHTLTVLGATSGDTGSAAIAGLRSKENIHIFILHPRGRVSPIQEAQMTTVLDDNVHNLAVDGTFDDCQDIVKALFSDKAFNDQHHLGAINSINWARILSQIVYYFAAFFALRREQPQIDASSVQVVVPTGNFGDILAGYYAKRLGVPMSKLVVATNENDILQRFWATGRYEKESASGEVRATLSPAMDILVSSNFERLLWYLAHESDTEADDKEEAAGQQVTQWMHELKTRGSFAVSDAQWELAKRDFLAERVSNDETRSTIRRYFRTKEEPGSYLVDPHTAVGFEAANRRANGHAVPQIILSTAHPAKFSEAVISSIAADSNEGEAARYFDTHVLPKEMHGLLDKERRVVDVNAAPEAGSNKLQGLIASTKAIIERDGFSSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD82</accession>
    <name>A8QD82_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_4150</name>
        <name evidence="8" type="ORF">MGL_4156</name>
        <name evidence="9" type="ORF">MGL_4162</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
            <strain evidence="7">CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728671.1">
        <property type="nucleotide sequence ID" value="XM_001728619.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728677.1">
        <property type="nucleotide sequence ID" value="XM_001728625.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728683.1">
        <property type="nucleotide sequence ID" value="XM_001728631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD82"/>
    <dbReference type="STRING" id="425265.A8QD82"/>
    <dbReference type="GeneID" id="5852973"/>
    <dbReference type="GeneID" id="5852978"/>
    <dbReference type="GeneID" id="5853029"/>
    <dbReference type="KEGG" id="mgl:MGL_4150"/>
    <dbReference type="KEGG" id="mgl:MGL_4156"/>
    <dbReference type="KEGG" id="mgl:MGL_4162"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4150"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4156"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4162"/>
    <dbReference type="InParanoid" id="A8QD82"/>
    <dbReference type="OMA" id="FKTDYPH"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="422"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="636" mass="71138" checksum="6E3ADCB23CCD1EFB" modified="2008-01-15" version="1">MPDITAGPVGLVTAAQLLRIGLTVKIVDKASAALSVGRADAIQPRILEIMKQLGLIDEFLGSGPRIDHTIFYKDGKFMVFRRSHSSQSEFKFLQVIGQPEIERILIRDIERFGCHIDRCTTLSGYYPVEHVDSAGIKRVNLRFHLDDGRDNRGAICDSTYLIGSDGAHSFVRASLSIPFDGIATGLVWQIVDCEWETNFPHAWVFGCVLNSTHGGVLIIPRENNMARLYVNVIPEDGQATVDRSKESVSTALERIRKVFHPYTIKPKGPIEWYTIWSINERVARDFCDPTNRIFLAGDAAHCHSAAGAYGLNTGIMDSQNLVWKLALDAYGIAKPNLLSSYQTERRFTALRIVEGSSQFLRFLCNQQSTSTFAKQFQFNEDEKFEAPVFVAENEPEGMDQDQAFFAWYAKTYTGLLTGMDVGYKPSLLNAWPAACKKQRADQIAETYLSSPMKDVCSEGSAIVPGHPMGNPLVFSQSRKRVQRLYDGFLPSPAFNIVIFIGSFSGLIRESVLDAVAHFARPESFRLKFTSQPIFKLHLVTTRCNSMDTHQCVTIPLGLTFQNNACQGDDPDSWISVYLDDKPEAESAHAFFGIESNDSLEQERVMVVRPDLWLGTKTTLSNFKQGLESYFDGFLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD98</accession>
    <name>A8QD98_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_4166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728687.1">
        <property type="nucleotide sequence ID" value="XM_001728635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD98"/>
    <dbReference type="FunCoup" id="A8QD98">
        <property type="interactions" value="438"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD98"/>
    <dbReference type="GeneID" id="5853027"/>
    <dbReference type="KEGG" id="mgl:MGL_4166"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4166"/>
    <dbReference type="InParanoid" id="A8QD98"/>
    <dbReference type="OMA" id="HDIYGSM"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26333" checksum="20BB6BE1FF6B604A" modified="2008-01-15" version="1">MVWPFSSTTNESQQPAATQTAASHSGDATEYLRTHSFDKSSGGMSTTTPEDAPTAAGLLRNTALDPARLHPFADIKDDLEYLDIEDDRPNTIQGARTALPSRGWSDDLCYGTGTTYLGGLSVGALIGLREGLTRPLGIDSPTFRLRMNAILNQVTRRGTFLGNSAGVIALTYNIFDATIDAVRGEHDIYGSVASGALSGALFRCTCTLLIFCALQKNFHINLFGMLLTLKQQRVHELCLCRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDA5</accession>
    <name>A8QDA5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_4171</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728692.1">
        <property type="nucleotide sequence ID" value="XM_001728640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDA5"/>
    <dbReference type="FunCoup" id="A8QDA5">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDA5"/>
    <dbReference type="GeneID" id="5853000"/>
    <dbReference type="KEGG" id="mgl:MGL_4171"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4171"/>
    <dbReference type="InParanoid" id="A8QDA5"/>
    <dbReference type="OMA" id="RKMETQP"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="126" mass="14676" checksum="62D96EB42CF4D2A3" modified="2008-01-15" version="1">MGQIHRKKRNHHARRDVSRAARTRARKLDYDQRHENATDEAKRQSLEAPTELDPEKAGLGMFYCVECDRHFPNMNDRNAHVASKQHKRIAKKVLTEKPYTHEEALRGAGIGVDHRQRNSDKIETEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDC7</accession>
    <name>A8QDC7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-binding TFAR19-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728706.1">
        <property type="nucleotide sequence ID" value="XM_001728654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDC7"/>
    <dbReference type="FunCoup" id="A8QDC7">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDC7"/>
    <dbReference type="GeneID" id="5852999"/>
    <dbReference type="KEGG" id="mgl:MGL_4185"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4185"/>
    <dbReference type="InParanoid" id="A8QDC7"/>
    <dbReference type="OMA" id="MQYEMQK"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12037" checksum="1BB4F020C7407A84" modified="2008-01-15" version="1">MGGVEPNEEQAAQRDELKRQMLSQILDGEARERLSRIALVKPQKADTISDLLLQMARSGQVRQRVTEDQLIMLLDQVDQATSQESTGKITVTRKKTLNDDDDDWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8QE57</accession>
    <name>A8QE57_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_4256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000026">
        <property type="protein sequence ID" value="EDP41392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728606.1">
        <property type="nucleotide sequence ID" value="XM_001728554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QE57"/>
    <dbReference type="GeneID" id="5852914"/>
    <dbReference type="KEGG" id="mgl:MGL_4256"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4256"/>
    <dbReference type="InParanoid" id="A8QE57"/>
    <dbReference type="OMA" id="EIGWGSK"/>
    <dbReference type="OrthoDB" id="3338260at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="47" mass="5412" checksum="27791D45003F537A" modified="2008-01-15" version="1">MKKDQKRNHCSVDDDGKLFMYRNHAPSMMPHGGDSLGGFLTWESKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8QEQ6</accession>
    <name>A8QEQ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000040">
        <property type="protein sequence ID" value="EDP41369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728583.1">
        <property type="nucleotide sequence ID" value="XM_001728531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QEQ6"/>
    <dbReference type="GeneID" id="5852891"/>
    <dbReference type="KEGG" id="mgl:MGL_4278"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4278"/>
    <dbReference type="InParanoid" id="A8QEQ6"/>
    <dbReference type="OrthoDB" id="3355236at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728180" description="Invertebrate defensins family profile domain-containing protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="3">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="156" mass="16327" checksum="97489A72E8983F5D" modified="2008-01-15" version="1">MMPLQYYHQQRSSKMRVAIVLSLVAMLFSVVSASSLCFGRPSFLGSTCAAECSVRGHHGGSYSNGQCCCGASTKRGEETHTQEEDLKSAEDFFGGKLLMSDDDSLEVHNGPSVSRVSCSACNIGGFNGGGLCCKASCATVGKPGGYCNGNNVCVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR75</accession>
    <name>A8PR75_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732847.1">
        <property type="nucleotide sequence ID" value="XM_001732795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR75"/>
    <dbReference type="FunCoup" id="A8PR75">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR75"/>
    <dbReference type="GeneID" id="5857153"/>
    <dbReference type="KEGG" id="mgl:MGL_0622"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0622"/>
    <dbReference type="InParanoid" id="A8PR75"/>
    <dbReference type="OMA" id="AFFHYRN"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="186" mass="20990" checksum="6A0943C5D89110CA" modified="2008-01-15" version="1">MSSLPPPPPKCVLHKEDEPLVWIDCEMTGLDPNNDRLLEIACIVTDGQLRPVDEGVSYVIRTQPHVLQDMDEWCTTTHTNTGLIDACLDAKMSHMHQDVRAAVLAYVLDRIPEARIACLAGSSVHADKAFLVNEMPELIKHLHYRIVDVSTIKELVRRWYGTKYEPARRNEGTAHRCVKTTAVTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR91</accession>
    <name>A8PR91_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732858.1">
        <property type="nucleotide sequence ID" value="XM_001732806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR91"/>
    <dbReference type="FunCoup" id="A8PR91">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR91"/>
    <dbReference type="GeneID" id="5857164"/>
    <dbReference type="KEGG" id="mgl:MGL_0633"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0633"/>
    <dbReference type="InParanoid" id="A8PR91"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="6">
        <location>
            <begin position="327"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="411" mass="45872" checksum="D6EDD27A6F5706CE" modified="2008-01-15" version="1">MAFSFLHPHGPPIDAQTQLYCFGTRTTPATHVIVHQEVQGDDYEMTKYTGPRYCPSLEVKVLRFAHKESHPVWLEPEGLTTTPQRDGHVLYPNGLSCSLSPDAQTRMVRTIPGLEHAVLLRPGYAVEYDHVDPRELLPTLETRRIRGLAMAGQINGTTGYEEAGVQGVLAGLNAGLRAQKRRELTVSRSDGFVGVMLDDLRLQGVMEPYRMFTSRSEYRLSLRADNADLRLTPLVHAVSPESITDTRLAALERVRADLDFGMQCLARTKMTSRAWASHGFQAADDVRTLSALDMMHRPHARIQDLIPFVPELRGLHPHTLERLATQASYMPLLERQASDIEAFQRDEALALPVDMAFAELQGVSDEMKERFSCVKPRTLGEAKRIAGCTPAAYAVLWRHAVMASKTPTAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRE3</accession>
    <name>A8PRE3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732258.1">
        <property type="nucleotide sequence ID" value="XM_001732206.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PRE3">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRE3"/>
    <dbReference type="GeneID" id="5856564"/>
    <dbReference type="KEGG" id="mgl:MGL_0033"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0033"/>
    <dbReference type="InParanoid" id="A8PRE3"/>
    <dbReference type="OMA" id="EIMFDDR"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="85"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1073"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1531" mass="173094" checksum="49D13869FB8EAA1E" modified="2008-01-15" version="1">MPPVSQPLAAYEAGTKAWFPDEVQGWVSGTLTKEPAVDQDGNVSLLFNLDESGDERVVQTTMAKIEAPGGVERELPPLRNPPLLEASDDLTSLSHLNEASVLYTIMNRYQQRFIYTYSGIVLIAVNPFFDLNLYGPEIIQAYAGRRRGELEPHLFAVAEDAYRCMIRDGKNQTIVVSGESGAGKTMSAKYIMRYFATVEDPDNMTSRRPGSHVMSETEQAILATNPVMEAFGNAKTTRNDNSSRFGKYLEIIFDDRHEIAGARMRTYLLERSRLVYQPDVERNYHIFYQLCAGAPEDLRAQLGITKASDFHYLHQGSEEYLTIPGVDDAAEFQATVDAFTTIGVARVTQMHIFEVLAALLHLGNVAITASRNDANMAPEDPALLQAAMFLGVDANELRKWTLKRQMQLRGEKIVSNLSQAQATAVRDSVAKYVYTCLFDWLVAQMNKSLAPRDEAAAASMIGVLDIYGFECFKSNSYEQFCINYANERLQHEFNRHVFKLEQEEYVAEQIPWQFINFADNQPCIDMIESKYGLLSLLDEESRLPSGQDASFLQKVYSQLQPKPEFQKFLTKPRFGSQSAFTVKHYALDVTYDVDGFMEKNKDTVPDEHLALLGSTSSPFLKSVLDARAAADAALPQPSTRKVSGPGIASKKPTLGTQFKASLGALMDTINSTEVHYIRCIKPNDAKVAWEVQPQNVLSQLRACGVLETIRISCAGFPGRWTFADFVERYYMLVPSSHWDMTSLEKVRELAQYILSETLEPDKYHFGLNKVFFRAGVLASFEQMRRNVLNEHTRTVQTAWRRYSAQSKYNALKAGILTLQANIRRRAAQNRFRTERELRAAVLLQTAARAALQRKHRAQAVHAATLIQTVIRAYQARLRLIDEREAWHATLLQTAIRGVLARRAASKRVRQVTLLQSLYRRRLARHALAQRRTEAKSASHYQEVSYKLENKVFDLTQSLQDRTRENKDLRASLLELEAQLSSWQNRHEELDARARGLQAEVQKPSVPIQAHETLQLERHALESQLHQAQERIHDLELEIATLQSQIRSLEAPESMVQSLRNEIVMLREQLSRATAENERNGTTVPLGPRAHVQRAGGVGTTGVATAGSRPVSEYGDEAFEDEYVEDVRDVPSEEIIDLLEDEVQLDEDVLHGLIEFLKIPAPSLQNPPGPKEVLFPAHLISLVTNEMWKYGLVRASERFLANVIRTIQQHAMSYRGDDAIIPGIFWLSNVHEILSFVCIAESDMLQGVGPGVDGSAREFEWGDYERLVTIVKHDLDSLEYNIYHTWMQEAKKRLNKMVVPALVESQSLPGFVTNDSGGRLLNRLLAGTNAPTYTMDDILGILNKIWKCLKSYYVEPSVTQQVITDLLKMIGVTSFNDLLMRRNFCSWKRAMQIQYNITRLEEWCKSHDMPEGSLQLEHLLQATKLLQLKKATMSDIDIIYDVCWMLTPTQIQKLISHYHVADYENPISPEILKAVASRVVPNDRNDHLLLPPEVDEAGPYELPLPREVTGIETYCPAYLNVPLLRSLASKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRG8</accession>
    <name>A8PRG8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732274.1">
        <property type="nucleotide sequence ID" value="XM_001732222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRG8"/>
    <dbReference type="GeneID" id="5856580"/>
    <dbReference type="KEGG" id="mgl:MGL_0049"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0049"/>
    <dbReference type="InParanoid" id="A8PRG8"/>
    <dbReference type="OMA" id="AVHTEVW"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="418" mass="45647" checksum="EB64224A158B66DD" modified="2008-01-15" version="1">MNQFLIARTLAGLGGGGLNTLNSVIMSSLVPLKSRGVYQGLSNIVYGLGVGTGAPLGGLLNDKIGWRGAFYVQIPILLVALLALSCFLGHDEGIHFGPGDSIWRRLKDVDILGLALFACVPISFLLAFDLVSVQNAPLFDKYVMSAIFIALIAFVLFLAVERTLPRFPLLSFSILSIRSVWSTASANFFISMALISFNYFFPFFFQTVAQMPASDVGLRMMPASFAIGVGSLAAGFYMRHYGRYYGYLCVSVVVLCLSCLPMAFYSSNPPKLLPFVFNVPLTFSQAGFFTCALVALVHVVSQESLGVATGMNYLFRSTGQVMGISLSGFLLQWTLSDELGKRILGPGSDELILQIRHDSTILPSLPADLRHEALLSYTSALHNVFLFIIGCYVCTMILSFFVENKHLDEPFSDEQDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRH2</accession>
    <name>A8PRH2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732277.1">
        <property type="nucleotide sequence ID" value="XM_001732225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRH2"/>
    <dbReference type="FunCoup" id="A8PRH2">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRH2"/>
    <dbReference type="GeneID" id="5856583"/>
    <dbReference type="KEGG" id="mgl:MGL_0052"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0052"/>
    <dbReference type="InParanoid" id="A8PRH2"/>
    <dbReference type="OMA" id="CETDIKF"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="320" mass="34852" checksum="A6CEA9ABEA4A253A" modified="2008-01-15" version="1">MVPRGAYEFLDTKETRAHLIEQYDNFLFDCDGVLWSGPTVLPGVVSFFRKLRERGKRILFVSNNASKSRRTLLERINAMGIDGREDEVFSSAYATAAYLKDVLRFPTDRKAYVVGMNGLEDELDANGIQYIGGTDEQDCQGLDGLDFSPLASKDALDPSVAAVVCGIDTKFSYRKLAKAFRYITRPGAEGEVRAGEQNGGCHFVCTNEDVTFPSSEGLFPGAGAVWKGIQVSSGRDPIVVGKPHQPMIDTIFARFAFDKSRTLMVGDRLDTDIAFGQRGGIDTLLVLTGISTLEHVHASDAAAVPTYVVNGLCDLDTALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSB3</accession>
    <name>A8PSB3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0226</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732451.1">
        <property type="nucleotide sequence ID" value="XM_001732399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSB3"/>
    <dbReference type="FunCoup" id="A8PSB3">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSB3"/>
    <dbReference type="GeneID" id="5856757"/>
    <dbReference type="KEGG" id="mgl:MGL_0226"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0226"/>
    <dbReference type="InParanoid" id="A8PSB3"/>
    <dbReference type="OMA" id="INLPVWM"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP45237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="383" mass="42721" checksum="105A523BA3D0ECD9" modified="2008-01-15" version="1">MRETDLTKYASLAEFFARELKPGARPIDTDAALVSPADGKILHLGIVEGDRVEQVKGLTYSLRSLLGQDSTAQAEHDIHPHMSPNMSIAAEQQFARLNGIDYSLEELLGSESSSGLHRAGTYAMGWIRSPWRWLKHMLTGTPSRAQETLPIHQVTQAELAADNQEQETRDAEEQDVGIPTSDTPKNLGHYANIAYEMGTQAIPPFQQQQGWSPAPGHHLYFCVIYLAPGDYHRFHSPVPWVVEMRRHFRGELYSVSPYVATRLPNLFLLNERVALLGRWRHGVFSMTPIGATNVGSIQIHFDRLLRTNLHDERKFTGTYAQATYNAASRILGGQPLATGDEMGSFLLGSTIVLVFEAPEQFHFVRRSGEHIKVGEALGRVVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSG8</accession>
    <name>A8PSG8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732480.1">
        <property type="nucleotide sequence ID" value="XM_001732428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSG8"/>
    <dbReference type="FunCoup" id="A8PSG8">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSG8"/>
    <dbReference type="GeneID" id="5856786"/>
    <dbReference type="KEGG" id="mgl:MGL_0255"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0255"/>
    <dbReference type="InParanoid" id="A8PSG8"/>
    <dbReference type="OMA" id="AIFHWIV"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046713">
        <property type="term" value="P:borate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF38">
        <property type="entry name" value="ANION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="72"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="258"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="468"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="642" mass="71991" checksum="706198A790AC011D" modified="2008-01-15" version="1">MSAHSAWTSSRGPHVDENVVLRHAEPGELAEEKPFTDARGVNAELNDNKNSEDRQAWHETPWSQRSWLYELRPFRGMWSDVRRRAPYYASDWTDALKPSNVLTVATSVVRIFFINLMPALAYVLDMYERTDHSYGVNEVILASALAAIVFSVFSVQPLTFVGVTGLTDLMNYTIYNIFHDHYGFDQIKYLRLQAWVLIWAAGFHFLIAMFNLCDLTRFITEMTSDTFGLYVGVIYVEKGIEQLILEFSLPDHDNATGWLSVTIAVLFCVSVYYLTLVGSSTYLTFQLRRLVGSLAFVAGCLFWTGFSHFPKHSLNEVPVSQLPITRSFFPTLDRGWIVDFWHIEVRWVFIAAPLGLMVMLLFFFDHNVSSVMAQARKFPIRKPAGFHWDFFLLGITTLVSGLMGLPVPNGLVPQAPDHTDSLSLYEQVILHDVEKEKQQFGEHTTEPMHHTSGDASILHVTYFPRVRTLRVVEQRLSHLVIGLLTLGAMSRPVLVALGTMPRAVFAGVFLLVGWASIESNPIVTRTLSLLRDTSALAPTLRPQVRRVTLALFVGIQWAFFGLTMAISQTIAAIGFPIIILLMIPCRVYVVPKLFSGKDLALLDAPTANAPAVMVSLGPNEAEIDTESDDKPKPAPSKHQGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSJ0</accession>
    <name>A8PSJ0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732491.1">
        <property type="nucleotide sequence ID" value="XM_001732439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSJ0"/>
    <dbReference type="FunCoup" id="A8PSJ0">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSJ0"/>
    <dbReference type="MEROPS" id="M67.A11"/>
    <dbReference type="GeneID" id="5856797"/>
    <dbReference type="KEGG" id="mgl:MGL_0266"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0266"/>
    <dbReference type="InParanoid" id="A8PSJ0"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="31"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="308" mass="34095" checksum="ED0429CAF8FDB85C" modified="2008-01-15" version="1">MDLQSLMGQPHMSSMGVANGDVPQQDNAETVYISSLALLKMLKHGRAGVPMEVMGLLLGTIVDDYTVSVVDVFAMPQSGTGVSVEAVDPVFQTKMLDMLKQTGRSEVVVGWYHSHPGFGCWLSSVDINTQQSFEQLNPRAVAIVVDPIESVKGKVVIDAFRLINPSTVMLGQEPRQTTSNIGHLNKPSIQSLIHGVNRHYYSMAIGYRKTQLEQSMLGNLHKRNWTDGLKLADFQEHQHSNQAAVKRMLSLAEDYQKSVKEEAKLTPEQIKTHYVGKQDPKRHLEDAVETSMGDQIVQSLGTMILAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSZ1</accession>
    <name>A8PSZ1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="14">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_0340</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="14">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="14"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732565.1">
        <property type="nucleotide sequence ID" value="XM_001732513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSZ1"/>
    <dbReference type="FunCoup" id="A8PSZ1">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSZ1"/>
    <dbReference type="GeneID" id="5856871"/>
    <dbReference type="KEGG" id="mgl:MGL_0340"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0340"/>
    <dbReference type="InParanoid" id="A8PSZ1"/>
    <dbReference type="OMA" id="LMEFHSQ"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="67"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="257"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="488"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP45351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="542" mass="60882" checksum="7C42A9689C487C84" modified="2008-01-15" version="1">MAKHAAPDAEEARLERELQQDAKKAEASSEKLPDRKPFTALDLTPATSKALDAMGFKTMTEVQERCIPPLLAGKDVLGAAQTGSGKTLAFLIPAIEMLQRLKFKPRNGTGAIVISPTRELALQIFGVAKELMAHQSQTLGIIMGGANRKAEADKLQKGVNLIIATPGRLLDHLQNTKGFVFTNLKTLIIDEADRILEIGFEDEMRQIVKILPQEHRQTMLFSATQTTKVQDLARISLRPGPLYINVHEQMAASTVSKLEQGYVVCDSDKRFLLLFTFLKRNAGKKIIVFMNSCNSVKFHGELLNYIDVPVLDLHGKQKQQKRSNTFFEFCNAESGTLLCTDVAARGLDIPAVDWIIQYDPPDDPRDYIHRVGRTARGGKHGRSLLFLLPSELGFLRFLKVAKVPLNEYTFPPNKIANVQNQLEKLISKNYYLHQSAKEGYRSYIQAYGSYSLKRIYDIHQLDLAKVAKAFGFAVPPKVNVTIGTGLKVKKDREHNHPDDEDNDERRGKRQRVDRRSYGARDEKAARYRNQTPASANGTQWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTF1</accession>
    <name>A8PTF1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732639.1">
        <property type="nucleotide sequence ID" value="XM_001732587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTF1"/>
    <dbReference type="STRING" id="425265.A8PTF1"/>
    <dbReference type="GeneID" id="5856945"/>
    <dbReference type="KEGG" id="mgl:MGL_0414"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0414"/>
    <dbReference type="InParanoid" id="A8PTF1"/>
    <dbReference type="OMA" id="EMQTKSY"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="30293" checksum="4DCE7FA1103B2D01" modified="2008-01-15" version="1">MMFALRSGLRAITPRAAAPLSSRAMLSTSVPRLMPVADSAAEYTCIQVSTPKEGVRLVTLNRPKALNALNSQLFHELNDAAEKADADASIGAIVVTGSEKAFAAGADIKEMRDMSYGQAYKTNFLGHWSKLTQVRKPIISAVNGYALGGGCELAMMTDIVLASPSAVFGQPEINLGVIPGAGGTQRLTRAIGKSRTMEIVLTGRNMTADEAEAAGLVARVVREGSVVDEAVNVASKIAKKSQIAVQAAKEGVNAGTYSRLSLTMITSLRTHACGGHPSRAPSVPGTLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUA4</accession>
    <name>A8PUA4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732048.1">
        <property type="nucleotide sequence ID" value="XM_001731996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUA4"/>
    <dbReference type="FunCoup" id="A8PUA4">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUA4"/>
    <dbReference type="GeneID" id="5856369"/>
    <dbReference type="KEGG" id="mgl:MGL_0641"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0641"/>
    <dbReference type="InParanoid" id="A8PUA4"/>
    <dbReference type="OMA" id="LRFQDTI"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727872" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="641" mass="73836" checksum="DBE7AD27E8F82832" modified="2008-01-15" version="1">MLWSAVVCVFLSALWHAHAKQRPFETPLLEAPLLGRFLHITDMHLDKHYKEHAAVVSQCHRDKPHHSHGGERRSGHWGSQESDCDSPFTLANATFQWLAREWDAEDNRGQSYLPFDFILWTGDSARHDQDVELPREEEEIYALNRYAVSLFESYLPGVPVVPNFGNNDILLHNTMSSGPSKELDEFARIWQQHIPPDQMDVFLRGGYFAKDLIPGRLGVVSLNTLYFYDSNKAVDGCPRRSRSEDSVNADPGTLQLEWLVEQLMDFRRRNMQVHIIGHVPPTAGNYFARCFDVYTELVLRFQDTVIGQHFGHMNLDAFFVQESSLAGSSKRPSNKVPIFFKQIEVDLRYDYESLPGNARTDMQYYGVFYEAPSLVPTYLPALRVWTYNTTMEHSNRPVSTQSVDLDLLLDFVAYDNCSEDDRSLDCALVGEDEHVYDNDDDSANSINMLGGGRRHRRPKRKHRRRHTKLPRYASSSAPSRSNTFLTPLGYSQWTLQLDKANAEYDRVLKAQGAAAASALPLNYTLEYTTYDAPTLWHQFIDLIIDPQETLPPPRHHELPSEHHVPVPKPLLDRHLEDRGLHSPYTCQKDVCRIAKPLKPLTMYGLEDMTLRSVMDLARRLVLDRKMWKTYVNRLYTSIWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUH3</accession>
    <name>A8PUH3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732093.1">
        <property type="nucleotide sequence ID" value="XM_001732041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUH3"/>
    <dbReference type="STRING" id="425265.A8PUH3"/>
    <dbReference type="GeneID" id="5856399"/>
    <dbReference type="KEGG" id="mgl:MGL_0686"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0686"/>
    <dbReference type="InParanoid" id="A8PUH3"/>
    <dbReference type="OMA" id="GPIDKGD"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="260" mass="28988" checksum="770FA6806518F949" modified="2008-01-15" version="1">MSLNAFLPPSVRLNASSSSAQAVPRVQAHIMPFSIEYNGPAPVGTYLLMESPLEPHLAPMGSANPSRFDPDESDEAISSFRGRYIHGTRAYLPDGYKLGFFRMSRALACSEMPNEYEHIGDQPRRNAQSHLIAPPAPTQGSRFSLDDDEDAFNDCIGKDESDEEEHATAHRTYREQENILHMNESDQLSAPESLHIPDRHQDECGAPALYHRWELVLNAGASFWAWGPDGPVDYGSHAFLRTCNEWIKVIVPFLHGTDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUH9</accession>
    <name>A8PUH9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732097.1">
        <property type="nucleotide sequence ID" value="XM_001732045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUH9"/>
    <dbReference type="STRING" id="425265.A8PUH9"/>
    <dbReference type="GeneID" id="5856403"/>
    <dbReference type="KEGG" id="mgl:MGL_0690"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0690"/>
    <dbReference type="InParanoid" id="A8PUH9"/>
    <dbReference type="OMA" id="ACKMAAM"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="83"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="356" mass="39215" checksum="0EE456095307DBA6" modified="2008-01-15" version="1">MPGLPPPPYGAVFKGATLQLLEQAKELAGLSYRPSVFNPATLTKKGPVRVARSRVPPARPGEDPGFDMFFEMHGTGARRIALIMGLANSCFSWLDQVEEFGSDPSCSVLVLDNRGYGNTSSPAQRYTTCEMAKDVLEVLDHIGWTEDKSVHLVGVSMGGMISLEIARQNPQRLASLLLLSTTSGDGSPLPPAMGLVALTKSIFASMSGRTRNEARVNRMANVLFPLPWQEEKHESDPQGRKNGEVMRDILLWRSQFVLPPSTMGPLYQMSACLTHHVPPKELMKINNNIPKVGIVTGDWDQLVSPRHSRFMHKKMPDAEYHVWPGAGHAIHIQFPTAFNKFLRNWVGAPARDSAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUX1</accession>
    <name>A8PUX1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732198.1">
        <property type="nucleotide sequence ID" value="XM_001732146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUX1"/>
    <dbReference type="FunCoup" id="A8PUX1">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUX1"/>
    <dbReference type="GeneID" id="5856504"/>
    <dbReference type="KEGG" id="mgl:MGL_0791"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0791"/>
    <dbReference type="InParanoid" id="A8PUX1"/>
    <dbReference type="OMA" id="LMEQFEW"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="292"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="855"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1039"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1095"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="860"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="929"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1039"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1118"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1246" mass="140346" checksum="8D7F37CF8E738BD6" modified="2008-01-15" version="1">MRNAKPLKRGEGDNDDDDNDDDDDDDDDDDHEDADDGDDDDDDDANVHRNTRTRAGRRGKRNKRALSPEALSTGEDSEEHEEDPMPPHRSYSFRARKKVNYSLLPAPPEPLRDGFGRRIRRGSRSASHGSSRAIHRDQDTSNTVSHERSSQVTSLPHSSLPRSMQQHIGWDPMVQMNYANSLVDAMDSSDDEPARASGLQNIPGSNLHASSASALLGNGPAPTTGAVTSSTDTFGRLLREKDTLADVDPLGVNMDVDFTQIGGLGDHVQRLKEMVSLPLLYPEVFQRFGVTPPRGVLFHGPPGTGKTLVARALAASCSTNDQSIHFFMRKGADCLSKWVGEAERQLRLLFEEAKRCQPSIIFFDEIDGLAPVRSSKQDQIHASIVSTLLALMDGMDGRGQVVVIGATNRPDSIDPALRRPGRFDREFYFPLPSHVARRSILDIHTRRWDPPPDDQLKEVLASATNGFGGADLRALCTEATLNAIQRRYPQIYQTNERLLLAPETIQVNGQDFMLALENMVPASARSSGTTCAPLPTHLTPLLGEALSTCKHTFQRLLPTRAKRSALEEAMYEMDAYDAQECSASVLLERELLQQSFVQAQVHRPRLILHGASGLGQRILAEALLHSLEGYHIRTISATLLLGDSSQTPEAVLVHQFQEAKRLVPSVLYVPDVHRWPLMLSESLREVFSALLQEVSFSETIMLLATSEIPFLSLPSDIRAWFGYLPHCKMALSYANIEDRRAYFEDVAIQAARPPTQFSDTMPRRLRQLEELPKAPPRPPRLPTQAELKQMAENDARLLEHLKFRLGSVLAELRKKYKKFTRDVWDEYNLRTLMEQFEWFRSKGKITIKLRYDRHSLPASPDSTVAENEPSESNDTAEYNNDASPPSQQLHNPDEACIDSADVQTAIPDAPPETERHYIPVQMGQDATEHTTTPQEIQPTSGNVQDMHDDAERLYIMRDFTIYTMNLDKMQKRLYQNQYLTCEAFMEDIQKIVSNAEVASEVDRDRVFRAQQMENLAKILLDQIVDPTFRAECKQMENRVLAREEESRREAEKQKEQEVHSRRPNGQRYSARIQGEEPLAEHLIDVSKIERAHKRARSVSHDDIHAPECTTKASNEQLPHNETHDSTSKRTRLEVSASEQGYVNADASACMNALPASYAPCQSQVQRQNSIAVLDEAAKESLVHTLATWTDEFSVEQLELTRAACYERILAHRASWDRTLLVNELENLVKEIYSHIRSHDAEWHVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVV3</accession>
    <name>A8PVV3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pheromone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731695.1">
        <property type="nucleotide sequence ID" value="XM_001731643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVV3"/>
    <dbReference type="GeneID" id="5856000"/>
    <dbReference type="KEGG" id="mgl:MGL_0963"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0963"/>
    <dbReference type="InParanoid" id="A8PVV3"/>
    <dbReference type="OrthoDB" id="3340718at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="50" mass="5509" checksum="C43D9DE3B0792019" modified="2008-01-15" version="1">MNPTFNPAIDIKESVEMNSNVNYANEHPDEPATNEYPMGPPVWGTTCTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW70</accession>
    <name>A8PW70_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1038</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731770.1">
        <property type="nucleotide sequence ID" value="XM_001731718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW70"/>
    <dbReference type="STRING" id="425265.A8PW70"/>
    <dbReference type="GeneID" id="5856075"/>
    <dbReference type="KEGG" id="mgl:MGL_1038"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1038"/>
    <dbReference type="InParanoid" id="A8PW70"/>
    <dbReference type="OMA" id="FANDAQC"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="612" mass="65371" checksum="CE0364376F5E065C" modified="2008-01-15" version="1">MEYKTRVPVCGAILLSEDWTEVRTIIRSNYASHGLEQFANDAQCVLVKGWGKGASWTFPKGKINKNEDQRDCALREVLEETGFDAHDLLPKDSKDFFELTDREQKSRLYVVPGVPRDTKFETRTRREISRIEWFKLGDLPTAKNPKVPSSELGGRFYRVTPFMMRLRRWIQANKRSHPKRPNQQSPMPGHKDSGTSVNMDELFGTATPPPKPAGTQKPGLIALPPSAMRQLSSNKMKQPKDDVSAPPTRSSAPELANSKSSDDSKQQLLLSLLHGSHPLPAPPPSDQQPRIDGSAALRALLGAHSKRYEPSNPTQSQTHNTNSLLSLLQASKPPPKEPVEAHPMPYLRSPTSTGMQSLTPGSSVDKQSSNDREQHVANRLSSLIVGPNGSNGPSQPESKPDLPIVTGSTPTSVPPAQTPAPATTTPFNPVSRPGMFPFPHTMIQSSPSSWSGNSYIPQPQNAPVPTSGAVSSTLADATTAAGPTAPAAPSNRQQQALLSALLGSSKPQATSAHSTPSSPAVRTFSSHASNMPAPANVPQGPCNAPLPAPVTTPAPIPSDSGNAMNLLNILNRPPTSTPMRDSHAPASAAVPTSGAQNTSNSLLATLLHGKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW90</accession>
    <name>A8PW90_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1049</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731781.1">
        <property type="nucleotide sequence ID" value="XM_001731729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW90"/>
    <dbReference type="FunCoup" id="A8PW90">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW90"/>
    <dbReference type="GeneID" id="5856086"/>
    <dbReference type="KEGG" id="mgl:MGL_1049"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1049"/>
    <dbReference type="InParanoid" id="A8PW90"/>
    <dbReference type="OMA" id="KTILQVY"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="290"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="59457" checksum="D7348DEA7FC57D15" modified="2008-01-15" version="1">MATAPHINTSSSYGRSSGSMPGSSTDGGSSSAVQLPRTTNRYLSADADAALAMRSDKTTVGAVVTGLLVSGALQYTSTCLAMPFEVGKLLLQVQWVPREDVWKRVQASSGTTLPRRRKRSTSELEQDPWSDARSRSSSAWATGTDPDNDADQDGMSARGAGGHADGDDACDYEDDEDDDAPSKYFRDPSDVASTSASRRRVDKHGYVVPETQEDASTRPEFLMPVVVKGGVWEMIKAVVRGKEGWMGLWKGAFTTFLMDLSSTTLQSILSGIMSIFAPTALNPMPIAFSPQPIKTLTLLMTSHLMTGIFVSPLDLIRTRLIAQSTLPQHRKYKGPFDALRTIFREEGGWRTTYFHPNLLIPTILDYLFRPLFALSAPLLIENVFHLDPSAYPISYALAELVISTLSLGITLPIETVRRRLQLQYHEPLRNDRVGGLLTVPNTSTARRGLRTCVETRPVPYTGVAETVYRIVTEETAARSVAPKSDDGAMSDDEAPTVAASTHTRLSGLRGLYRGLSMGVTANLLVFVLTLLTGERQTQTTGWAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWE3</accession>
    <name>A8PWE3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NAD+ kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731811.1">
        <property type="nucleotide sequence ID" value="XM_001731759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWE3"/>
    <dbReference type="FunCoup" id="A8PWE3">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWE3"/>
    <dbReference type="GeneID" id="5856116"/>
    <dbReference type="KEGG" id="mgl:MGL_1079"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1079"/>
    <dbReference type="InParanoid" id="A8PWE3"/>
    <dbReference type="OMA" id="FIPFPRR"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="634"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="76406" checksum="D745E6001D5674C4" modified="2008-01-15" version="1">MAQDTDQVEYTPEHPPSIQGVLQESQKHLHKTYPDTCPKQELPYEQQQQDILDMDDAKDGDLLRCLTQKLAQTSIFVRAMHKQLYRARVNSNAESVLIITKARDNNLVRLTREVSLWLMNRARKDRKRGLIVYVDEQLRHSKRFDVEGMQRDYPHLFTSFRESGTPETSHQCFNVDEGQLRFWTSDMCTLSPTLFDLVLTLGGDGTVLFASWLFQSSVPPVIPFSLGSLGFLTPFCFDDYPSVLDSAITNGILLNMRMRFRATVYRAIDTLNSKPRSRRRKAPKPDSADSILQEVKECGWYCVEMEPGADAPEDAPLFHDEHVHLFRTRPVESFEFLNDLVVDRGPSPYVTMLEVFADDMHLTTAHADGLCISTPTGSTAYSLSAGGSLVHPFIPAMLITPICPHTLSFRPMLVPDSMELRIAVPHNSRSNAWASFDGRGRIEICRGDHIKITASPYPFPTVTPENETGTWFHSVSRTFNWNQRKHQMGFMVYDGHPNRKQSRGNPQTQNSASSRGTSRSGNRVKDKFWREENTSDFVHDASEQFDDDDADDDHDDDHYDDDEDDNEVFDIDEATPENLSRLSGSWGQSSFPTLPATSTFSQDNLSFGPSSKGEPVPIHYPTNELQEAKWRCIRSPDRFGPGGPPPAPGPLSERHLATMDFRLRSKLDDRAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWF0</accession>
    <name>A8PWF0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731815.1">
        <property type="nucleotide sequence ID" value="XM_001731763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWF0"/>
    <dbReference type="FunCoup" id="A8PWF0">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWF0"/>
    <dbReference type="GeneID" id="5856120"/>
    <dbReference type="KEGG" id="mgl:MGL_1083"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1083"/>
    <dbReference type="InParanoid" id="A8PWF0"/>
    <dbReference type="OMA" id="WMNWILV"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46595">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11077" checksum="E5E6D6956313960A" modified="2008-01-15" version="1">MAERLTLRKRNPYNTRSNRRRVVKTPSGHLRYLHLKKLPTAPKCGDCHTKLQGIKAMRPRAYATLSKRDKTVQRAYGGSRCADCVRTRYVSSLCASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWI4</accession>
    <name>A8PWI4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731843.1">
        <property type="nucleotide sequence ID" value="XM_001731791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWI4"/>
    <dbReference type="STRING" id="425265.A8PWI4"/>
    <dbReference type="GeneID" id="5856148"/>
    <dbReference type="KEGG" id="mgl:MGL_1111"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1111"/>
    <dbReference type="InParanoid" id="A8PWI4"/>
    <dbReference type="OMA" id="MSEPLQY"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="56087" checksum="65356742E16185BA" modified="2008-01-15" version="1">MSLPQTLVQQRAVALGTLLGVDAAAESMPHSASGSVLSTDDGDFDFFDADDMVDGVEYEMSGDDDEDDDDETDEAMVDVDNNDDKENEGALASQRAIERPPFSVPMTTLTGPRSNVTYRKTLPAPVTGEDVSLFSILKKNVGKDLTAISFPVTFNAPLSILQAVAEEYEYAPAILERAAKSADPIERICLVGAFAVSSYASTAQRSTRKPFNPLLGETFECVRADRKLNFIAEKVVHRPPVTASYAYGAGWRTTAAGTVKNKFWGKSLELIAEGTEVVELDTGDKYNIVKPSSFMRNLLAGTKYLEHVGEMTITNIKTDEHLVIQFKEGSMFGGAANRNHIEGTVYDANQAKVGFIKGRWDESVARITVKGKSEPLWEAEKMPHNASDYYGFTYFAMSLNEITDDIRHVLPPTDSRFRPDQRALEDGDADAAEELKLKLENEQRIRRKVLEETGEKHQPQWFHLGENGVDWEYGGPDGRDYFEERDKIEKTGGEWRIAMSDIFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWK0</accession>
    <name>A8PWK0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731859.1">
        <property type="nucleotide sequence ID" value="XM_001731807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWK0"/>
    <dbReference type="STRING" id="425265.A8PWK0"/>
    <dbReference type="GeneID" id="5856164"/>
    <dbReference type="KEGG" id="mgl:MGL_1127"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1127"/>
    <dbReference type="InParanoid" id="A8PWK0"/>
    <dbReference type="OMA" id="NPEFMAI"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="9">
        <location>
            <begin position="556"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="344"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="440"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="664" mass="72433" checksum="027EDC6A2BBDC9BE" modified="2008-01-15" version="1">MGSNGPPGNGGLPPSQSGIGIPGRSQQMNSGVQMNNMQGIQPMLASNPEFMAIVNAARQGRVSEEQLQQIRTILAQQQQRQNAVQQMNAARPVQPIYGTDASTMAQPAAANYMQQQAQPKPPTMSTMNAQSALPRHEATLMENFNRVMSPLMLNISQLEASLQNPSISAQDKQQQQTLYNELKGKQLSLARQVAVAREQARAKDQQQLQLLLQQQRQQQQQQQQQHLQQQQQKQQQQQQQQQQQQQRQQQQQQQQQQQQQKQQQQQQQSPQPHISQPQVQPQPQVQQQAPRPQHPSLAQHQPTQQPFSAQQKSGLTQTPVLSQNPIISQANARQVNRPVAEHPVATTQEPNRGSMPSTPQSSNKLPPTDANIRKNAQDTPNTMANAHAATVMRPNAPQSSWSNSSSVGAITPTSTLLPNGQNPVSPSSSLATMIAQQTMTPQPYPNASGPRPTLMQGLGASPATNTPPVLVRPNPLGRGSNIGKPSSSTPSSRGQNMDEIMGVSETNQGEDNAQQLGLENENVMSSQIADLLGTQPSASASLNYAGTSGGNNRLLTKRKVQELVSEIDPSEQLEGDVEDLLLEIADEFIESVTSFACRLAKHRKGDRLEVKDVQLHLERNWNLRVPFPGSMPIPPTRVKAPNTSKNMGGTGANANANNAGNSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWP6</accession>
    <name>A8PWP6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731905.1">
        <property type="nucleotide sequence ID" value="XM_001731853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWP6"/>
    <dbReference type="GeneID" id="5856210"/>
    <dbReference type="KEGG" id="mgl:MGL_1173"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1173"/>
    <dbReference type="InParanoid" id="A8PWP6"/>
    <dbReference type="OMA" id="PGLMYAF"/>
    <dbReference type="OrthoDB" id="3360262at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="494" mass="54688" checksum="3828003703DD77CC" modified="2008-01-15" version="1">MTSSHGFSADNAKISAPSASSSHHPWRMSASHREAPTFQGMYFPRYERYEHYPSSHTTFLSSPPSSSSPMFSDMATSATTSSDANASGFWHFHDPFTTTSPLFHAPPPPKSPNLVKPPSSSRESRLQGLGLVVPSNEPLTRRRSMSHSSAHSFEDHMAVHGGLDRWFPGLMYAFEPMHESTNHTPSLDDHVEEPLASVDDSVDYVAPPSAEPHSPPLRSLQLVSKYFGDEDPHGEQNDPILSTIPGLPRGSPGEIHGLGVSMSPRSPPQDMPTPLPQKRGSRLRPLHLAEMHRLEAHVPAAHASSGVEEDHVADVSNSMSLSRPSHARHQRIPFAILHPPSEKAIADPDAVRMFWYGFLGMPWLWLLGGWCLDDHGMLLSPWSPPSFASYRAGLHPYGPPFALSMHAHNQFLQRYSPSASATHSITLEPNVFGPEHRGVQFLAQYPPDSVRLYQLHQWQHTESFVLLNRMAAALSSFTFFACWATGVWTVVAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX46</accession>
    <name>A8PX46_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731139.1">
        <property type="nucleotide sequence ID" value="XM_001731087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX46"/>
    <dbReference type="STRING" id="425265.A8PX46"/>
    <dbReference type="GeneID" id="5855440"/>
    <dbReference type="KEGG" id="mgl:MGL_1322"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1322"/>
    <dbReference type="InParanoid" id="A8PX46"/>
    <dbReference type="OMA" id="WPSDETE"/>
    <dbReference type="OrthoDB" id="3343226at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="79"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="204" mass="22486" checksum="ADA481A6249F0539" modified="2008-01-15" version="1">MDEDEKVARPEPRPGDSDEEEDMPDYRVLSALSKKHLSAGSASVDAPAPSIPKRGEKDFEPTGFGGQVKALDESRNALFTTISLPRAHSSKTLSAATWDPQFQRAFVHVQRGQSCVHVGLSERRKLENGQSMTFLELFPEEAVYLIERGALDCRWTQTPGCIPSPDSFSTCIPISVSQAYSHLLGTDSSNLARYQARSLKNCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX67</accession>
    <name>A8PX67_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1343</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731160.1">
        <property type="nucleotide sequence ID" value="XM_001731108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX67"/>
    <dbReference type="STRING" id="425265.A8PX67"/>
    <dbReference type="GeneID" id="5855467"/>
    <dbReference type="KEGG" id="mgl:MGL_1343"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1343"/>
    <dbReference type="InParanoid" id="A8PX67"/>
    <dbReference type="OMA" id="RNDINTH"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="484" mass="53436" checksum="5BBD3BE79313C625" modified="2008-01-15" version="1">MGLEHSKLRHSGSSSAAEREGHSTTSNEQPNQQTNHQNGVTENSASTNNPPDDGFRAEEPAASKSLHEHRELVQKLRAQSGSNATSAADKVREEMQQAGIHDQRIDPVDETQTLAVDREPVTSDNESTVSSPTESESETESSSELDISVPSKREYADDDEDLGTTGEAPKTKNELDDDFPVPSISHVNQDDLHRLERIGTIHSVVDNVVLIEQTWEAESELKPREYDVLDSESLLCFENGQVLGLVYETFGSVQKPMYTVRFRSAEDIDSTTIQIGRAVYFLPSSSTFVLARSIRTKGSDASNMWDEEVAEDEVEYSDDEEELSAKRQAKKAKTCRIQQQPAVSSTYHDLDPATASLGPLGNQYVSSGAPVAPGGRRRRSSRARNDINTHVWSGARTPFPHGDYSNERGGVSIPHINPRFADQWIRQGSTPPMPYPPMPVPPVFPMSVTYSPHHPSMVQDVHNFIHEAYNPHAPGTGYESPHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXG2</accession>
    <name>A8PXG2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731255.1">
        <property type="nucleotide sequence ID" value="XM_001731203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXG2"/>
    <dbReference type="FunCoup" id="A8PXG2">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXG2"/>
    <dbReference type="GeneID" id="5855562"/>
    <dbReference type="KEGG" id="mgl:MGL_1438"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1438"/>
    <dbReference type="InParanoid" id="A8PXG2"/>
    <dbReference type="OMA" id="MHRIMVT"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="306" mass="33866" checksum="4C84A85444A36FEB" modified="2008-01-15" version="1">MRYEYSNMQGKRKALLIGINYVGTSAQLNGCWNDAHNMANFIRQHAGYHPDDMVILTDEASDNPRTKPTRENICNAMYWLVRDAQPGDALFFHYSGHGGQERAVEMDEEDGYNETILPLDYQFTGQMADDEMHARLVRPLPIGCRLTALFDSCHSGTALDLPYVYTTSGKIKETNISMNVGKGLLNAAMDYARGDVGGMVRGLFNTVKSTTLNTRAGKYTRETRSSGADVIMLSGCKDCQTSADAVEAGKATGAMSWAFITVLSQWPQLSYKQLLNATRDCLAAKYSQKPQLSASHPIDMDLLFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXG3</accession>
    <name>A8PXG3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731256.1">
        <property type="nucleotide sequence ID" value="XM_001731204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXG3"/>
    <dbReference type="FunCoup" id="A8PXG3">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXG3"/>
    <dbReference type="GeneID" id="5855563"/>
    <dbReference type="KEGG" id="mgl:MGL_1439"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1439"/>
    <dbReference type="InParanoid" id="A8PXG3"/>
    <dbReference type="OMA" id="YYGWMKK"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="416"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="971"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="781"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="627"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1132" mass="120537" checksum="457C1890F2048236" modified="2008-01-15" version="1">MSTQPVEYVYALYNFDAENPDEVSFRVGERVLVVEKDDAYGDGWFQGTNERGETGLFPFSYTTYDESAAMTMLNGAMSRRYQHSPHIGSPTMGMAQLQQPEQQEPLSSTASPVTHASGPATSGMATNSHAVPDERGVMHSTMNDIENALSELHTTQPPQQMQPQSQDQPSLRNISSPSQQLPSDMDDPIERDFQARAAARAELARNAQKSLQSQEPPWDTPSGVGEPGSISNARQMQSSSQQGVVPLAMLEMSDDSELDDDEDVASVGPSADPNDNRMNPLYSQLPANQQRGMTPTSPPLSSLSLPQQQQQQQQQQQQSPAGLYAGGGIRSPSASQPSHSVQSSHQEAISSQPPNQGTDVAKHTYSQSVSASYVPPRDPVLPVSEPQVPNRMPDVSAAQEPADEPAAEATSDPLSWSIDDVVDWAISKGFDDQITNKLREHEVNGVTLLSLDIHTLREIDIIAYGRRFRVANCIDELRHGTPMSPSATSPRDASSRMPYNTSTMPRSVSATAAPLSPMSPRPSGTELPLSPVHRDHQHAPVSPGIRSPSQLQQQQQQQQPMPYSQSTPKLQDPHALAPATERAPSSLGPPIQEATPGFSSSGAQSGDGSMNQAAPPVGLSPSIAGNAVTNPRSASPALNMSAPQSAQSPGATAFAAPVPESARASAPGFGMPRSASTRTNNVPSQPLPQSSPMGYMQSHGNPLPSFGSGEGMNLNQRGPSPIPSASVAPNSAPMEQQDLLWQQNRQRMENAPPTMVPGGPQEQAGMTNKVVTPMPATPPVVPPAAPSAAPVGVPRDMAPEPVSATGMPGMPSTMPSQSPLPTITPGSGIPGGQPPSMGAPWGSQPSAVMPSGPGTPSRSGPGPNVPPMSMQQQGTPTLATPRTMPPTGTPVGKPGFMNTINSYGPSGPPRTALQSNPAMGTAATTALSMLPYTKGGHRPQGLLTGTENHRAGEAGGGRPTERQTVLNRLGQIDRQGWIKKRGDRYNRWNSRYLVLHGMDLIVLRDPSADKVKNLIPLHGYKVVSDESAGSGFSFKIVHDTERTHHFSLDDEVALRGWMKAIMKATIGRDLSQPVISSYSNMTMTLEEAQRLRPRPPSPTSRMRVQLENARFNPGQLTSKDAMVLTSLDKGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXP2</accession>
    <name>A8PXP2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731310.1">
        <property type="nucleotide sequence ID" value="XM_001731258.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXP2"/>
    <dbReference type="GeneID" id="5855617"/>
    <dbReference type="KEGG" id="mgl:MGL_1493"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1493"/>
    <dbReference type="InParanoid" id="A8PXP2"/>
    <dbReference type="OMA" id="TTCTKVK"/>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="11"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1656"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1732"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1865"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1988"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2066"/>
            <end position="2176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1544"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1900"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1988"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2013"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2034"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2095"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2142"/>
            <end position="2166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="2176" mass="235225" checksum="5F937F9AC42BE9BC" modified="2008-01-15" version="1">MEMATAYVIRIVERIRTFGVDMPLILSSMAMDLSAADTTRLIRTVIDTLRSPSTQADRAFHEELKFASVHSLVALLKWILARVGCVVAERTENQTLVLKQERGFVPWMTYTSWRAQESADGFSTLSYVVLARRLEKRVARLLDTVMDFLALVATHSAQNHMTPSKVGRHFGALLFGLPEDASFAETYGAYVRASNAAEHILLAFMRYHVSMAKASTYLPRRLLRLIDDYPRMLSPDLDASSSAVQTVPATYVARHVREYAHDLIDRASWPSELQGWDFAQETCKMLNVVPYRSLRPRSSQYRHDSPTELADGYVSTLMQRWNEFSFEGFNDLDTSFLNFDLRESDRRQRMKRPESMQWYQFEERGFHQNADDNSRWDWVMRLDEPSEQMPVLVHEGVPRSESHVFQGEQVDFPCDTVPHTAETVMDELFPQVWADYLIGNGWSQRDERVHRDASFVVLQLQTDTRPSSGRPADAASPPPLSLSTKWYVLEEVVPAAYRDTLDQLGRTRRHSMPMLRKLNQFRMVRAGLAPESTVSVVYRLGADGSAGVSADPGVPAAFEANKTSVPHGSLGSTPSERPQDPSSTAARTSAPTTATNTPFTEPAFPRASAPPDPLPDQPGIPMDDQADMPPPAPPKPWRREGAAAPTTDAHAVDHRAEQHQQHQHDKNQHDKRQHDKRPHDNFQRPSAKTSTSPEVATASGTTAATTHPSPVPDGEPARGKRSIRKILSSIGSPRRMHESPRMPWSPFARSPQLESSVQDHGPAVPMADAAATTDGHGGLGSAAHSSGKTAAGLLGNIRKRSSQWILKSKQSLRSVRAHSNQEDRAPIREHVGPTGAMHGDRIPSDGGAPTSDAPTRADAYPAMDRMLPRAPEMNEQDAPHGQPHPPSVKSEDQAELRSGVATIQMHHLSPDTGASPPTQSPSSIVDWDKFSPLTGGASSRHSTPVVGTNASPRVDPQGLWRDAGAKPHGSPASRPVSMMIPRKQTPILSPEQVAAISGTSLPRETPPMVPRRDSASPMMPQPVAQESRPTSSSPLVPHADQDKPTHSTASRIPSGEHAPAAPDLPHDVSAEKNAARAAASSKLSMPSPRQQPDGNVPVIADRHTLQSGIDSAAATADASRPIKRADEEPRHDHSPFMRPAETTAATMTVPPHDPAIPTDVELTSTPRPAPPPLSSSSANAEPRAMHESTKLSPPIVGAVSSPRAYDTQQLVTVSHITPVAHEPPSRAAATTAPSAWPPMASTASTLPATIPPSVESHTDAMGQGIQSPASQDAPSATPLAVPTLLQRSPPSTSSPDNHSPVAPPMSWTTLPPYVFNSSAAAYLSPPTPESPDAFADASSEFGAPSIQSPLMSGPTLPGVAPALPQAVPPAAKPHDYRLSCITEVSEDDATRSSHRFSATSQPMEMALRDASIQTLVESDGPTTRAPVEEVAKENHGRPYQTDTYGTLHHGPTQPTHQVDGADELTRHEHPNVHRDRHVHESPDVQEDRHVYGGRDTHGLGEHESAGFDRIPEARHINNVHHTHELQNHASDAEIPAAMPDASPTAPTDTLSMEHGSSVSSALGQTYSATSSVADSEQEHDAKRRARWSGLYMDALDVLDAPDENAFVHAPTEPRQPIDRKTDLPQSVPYAILPDTDAEEMVGSDPELQRMTDGNTTLHAQQPDHTAVERADTLAGEPAGPTRNPFLLPQGTEPRSEPFAPWLELEWMNKNTQPPTHPAELAGAYVPYLRDSLNATDSPAEGQKDTRLPLPTKEASPPHAVAESSSTTMPHKSSFRRVPQPTTLESVPDAEAPADNSMTSVAVASANDYDTPGTHAPMDASMTSRTFTSRDIAPADSQPPSVWMKKAPQDNDRDLLKTSHAQIDEVPSLGIPSPKSMHLSTEEPSETPMNSTMPLLTEPVSTPTASSAPATASKVRVLSTSELPAAAAEIAPEVSTSSVQAQVQAQAQAQAQAQAQVPATLVRHMNMAPSVTSTNDIAISELNASTTESLANENTDATSPVRPNFAQGAGPSQASSTADSAPALTPTAPADTRQDQQVVENSFPRSRSSMTKLAGFTRPSFSFDNLMQKSHSRQSHQSSASSPKPDNASTSKKALPTSPTPTTDTPTSSAWPQADQADTSSDSDWASSQHARQPIVVSTSTIRRVDPSVEPPRLDWHTFSDETHEADTSIPGEFPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXP5</accession>
    <name>A8PXP5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731312.1">
        <property type="nucleotide sequence ID" value="XM_001731260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXP5"/>
    <dbReference type="FunCoup" id="A8PXP5">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXP5"/>
    <dbReference type="GeneID" id="5855619"/>
    <dbReference type="KEGG" id="mgl:MGL_1495"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1495"/>
    <dbReference type="InParanoid" id="A8PXP5"/>
    <dbReference type="OMA" id="FLWSDIM"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="107"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="326" mass="37583" checksum="3BA24782B886B331" modified="2008-01-15" version="1">MAKSRREQKEQQQQQHGAAISDERFDLSSWEPASHTEKKRKLEDTDDDVLGNKTDNGSPDSDADDNDNDMHNHEAHESYEPHGSESVLPVLSREELEEYKKKQQKRGVIYLSRLPPGMTPAKVRHIFSQFGEVGRIYLQPKDKQNSSSSSSKKKNRPSHFSEGWIEFVSKRVARTTAEMLNAQPIGALGGASHSSRRSQSGAGAINRWKDDVWTMKYLKGFRWPMLMEQLSHERATHAARLRMELSQSAHEQRDYLRKVERSRIQRKKQAERAEPPTNEDEAPAPKRKFQQRTPVYRDVRDQRVQNHSRTSAPAGQDMERVLSQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXT7</accession>
    <name>A8PXT7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1522</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731339.1">
        <property type="nucleotide sequence ID" value="XM_001731287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXT7"/>
    <dbReference type="FunCoup" id="A8PXT7">
        <property type="interactions" value="632"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXT7"/>
    <dbReference type="GeneID" id="5855646"/>
    <dbReference type="KEGG" id="mgl:MGL_1522"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1522"/>
    <dbReference type="InParanoid" id="A8PXT7"/>
    <dbReference type="OMA" id="WINYFGH"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="390"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="736" mass="81244" checksum="A362F4F78B909EF4" modified="2008-01-15" version="1">MQPPDSASQSTCTASDVGDVRPQKRMRQSEPRRLCEHDVGLLTYVHPDWRPVHAIIKQRYADFLVREIAPDGQVVRITSLDPPGDSGFRSQAPSKDSASWNDLLPYFGEEQLAQLRSLCEHGPVDSRVLADKTERTQIHRLVRALAGDSLVSDTVVVESGAYAGHSTDAAPASVVRVQKQSGGPTSYPSSSSSSSSSSAPVQSSSSSRSHSRPRSRANADPDSEAMAAPPYIHFTLQKTNRDSQEALQWLARFLKLDHRGRSSSANMLSVAGTKDKRAVTVQRVALQRGRRTLHDVWNMVNHIGQPVSSAPGDTRRRSVACATTTRAERGLRIAHLSYADAPLQLGMLNGNEFTITLRDVRWADTTELGSDAAELRAFLATRVQEIQAHGFINYFGMQRFGTGFVSTHRIGIAVLRGDYHEALHLILDAGAMEDGSNRSHGSGHDSHNDKHVPTQPRHDAENDDDDDDGAPPAVLASRQAQAAVRDQRYHDAYRLMPKKCVAERAVLEKMKAPYWSPTDPLGAFQNIPRSLRLMYVHAYQSYVWNRLVSERVRRFGALKPVVGDLVLVNNMAVELDEQSVSRYTMQDVVMPMPGADVHLPPDGWLASMYEDILRGDGLTPSSLSSSAQPEYRLKGAYRRMLQMPQHLRHTLLAYNDANATLCATDEEVLLPDHGTQGPGAVDVVDKDQQAPFLALQLTFELPPSSYATVMLRELLRTDTSAHLHKELTKQSIDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXW7</accession>
    <name>A8PXW7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731358.1">
        <property type="nucleotide sequence ID" value="XM_001731306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXW7"/>
    <dbReference type="FunCoup" id="A8PXW7">
        <property type="interactions" value="763"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXW7"/>
    <dbReference type="GeneID" id="5855665"/>
    <dbReference type="KEGG" id="mgl:MGL_1541"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1541"/>
    <dbReference type="InParanoid" id="A8PXW7"/>
    <dbReference type="OMA" id="NICMAST"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="748" mass="81986" checksum="F07140BF9E5A105D" modified="2008-01-15" version="1">MAKNAIKRLRTIRYPNILKFLDTTEHQGTLYLVVEPVEPLSNTLTLWAQGKGRDASSSAWIAWGLSHIASTLAFFHQNMQAIHGNVHPGSVFVAPSGEWLLGGMETLGSPIEPGSIIMRYGGLPPHANKYTPPELARAGWGTISQSSIHAVDSYGLCLLAIEAYNGSLPSNMSNFPAGRIPASLYTLLRRMANPRPELRLSPADMLHLGSQPNGFLSTNVLVQANQILEDFRVAHAVEKGGILSQLLCFQEQLAPSFSQFKVLPALVETFRYKNGSREVDLEFSASALLPLMLRIGEKMDSVSWNHVLGEPILGAMGSSFQPIRMVLITDVCYYAHQLDTRAVSHQLWPLVWKSFQSALDTQRQAALESIRLLIPKFSERILNNELLRELAKMQKDVRPAHRLQATKLLSELSPRLNARTKADVLIPAFACSLKDAYDETRLAGITAFRENSDNFDASTSACQLIPALSPCLVDANLKVREAASETLHFYLEKITQYTQSMSSVNVEMPQSIPGDMDPQTLLSGERMSEKEGSRSTFTSFLSATAGSAATALSEWAISQIEEDDQLASQMTRSLDETSKAKSFSAQSTPEISTPPAVPFHSNKGMSLSPSVSKVEKITQEIMQPARTSTKPIIPKLHQSSAQPREASPLTRPPVMDTSASREVTDVQDLCQVPPKPISAAAPPSHDFKSSTKPTSAAASKPAPNIYSTIPASKSLSKEEKMAQLNKLREERRAVSIRFLLIIAANHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYQ4</accession>
    <name>A8PYQ4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BCD1 alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731522.1">
        <property type="nucleotide sequence ID" value="XM_001731470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYQ4"/>
    <dbReference type="STRING" id="425265.A8PYQ4"/>
    <dbReference type="GeneID" id="5855829"/>
    <dbReference type="KEGG" id="mgl:MGL_1705"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1705"/>
    <dbReference type="InParanoid" id="A8PYQ4"/>
    <dbReference type="OMA" id="DYQFLNQ"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCD1 alpha/beta" evidence="3">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="420" mass="46730" checksum="376FF0DEAA4F85FC" modified="2008-01-15" version="1">MNAYDYNQMMEDYQFLNQVGRMVSSTGRAIYDAKLMNGVPNGLPGSSTRHVPVTQQRREALAKQLAFHKLPIMLLPDGMSKRKMNRTQWDAKRRCMLYTAQITFPCAPSQPNNPLSHIQKGGWLIHRLEGSVDMTICVLSEMERICARMNNMSLSQWKSHQSDPERAPKRIKSESATPALISPSVWSSLGVPYASAHERGILPENSVMLLHVYEKRLRNESSAKFLDWWIRKGSALESSNCVHSPTPSEPSIVPPHVLDAVSQLRPDKNDVAKSPGSSTLRQCYVRIEPGLSFEKVLRSIPTAYGIVEFFELEIWDIEACRDAERRNHVCILPLEPHETVPENASRPRNHVRHNEAPGASCMNPAENNKDPNKNTNGIGAGSTTNVATLANTTVSCTATSDPPSSITTLVAYSSDSETEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZQ9</accession>
    <name>A8PZQ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger C2H2 LYAR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730942.1">
        <property type="nucleotide sequence ID" value="XM_001730890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZQ9"/>
    <dbReference type="FunCoup" id="A8PZQ9">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZQ9"/>
    <dbReference type="GeneID" id="5855249"/>
    <dbReference type="KEGG" id="mgl:MGL_1941"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1941"/>
    <dbReference type="InParanoid" id="A8PZQ9"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="9">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="179" mass="20252" checksum="08B7ADEF84A9B519" modified="2008-01-15" version="1">MVSFVCDGCGDVVKKPKLPQHFNRCYSPFTCLDCSVQFASPKEAHNSCVTEDEKYQKSFYKNKKRVSSSSNAGQESAHPMKRTAQEAVGTEKDGHKRSKSDAMPAKHDTLPTDSQSALTTTELKKAIAHLSQKQDSVHFCDVIKYLCNEKHMKKKSVKKFLMRKVILSMDFSQDRLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0K0</accession>
    <name>A8Q0K0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_2044</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731045.1">
        <property type="nucleotide sequence ID" value="XM_001730993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0K0"/>
    <dbReference type="STRING" id="425265.A8Q0K0"/>
    <dbReference type="GeneID" id="5855352"/>
    <dbReference type="KEGG" id="mgl:MGL_2044"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2044"/>
    <dbReference type="InParanoid" id="A8Q0K0"/>
    <dbReference type="OMA" id="FKTIWTL"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17951">
        <property type="entry name" value="DEADc_DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="201"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="409"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP43831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="606" mass="67527" checksum="85D3F58C0B7E9D75" modified="2008-01-15" version="1">MITWDEPWWALADDDESHELYVPLKKRRMGAQNARQEKGRLNARTAEVATDDVATVTTTGDTGEPSEGTVKAKAPSLMQQARTIREHLYDTKSHADLQAEEEEHILEAHAARKKLAGYAEIARDIHYTETVRRSWQAPHFVRRRTDLENAKLREKYRVSVEGRDPPPLISNFRDMKVPDCIIDHLKAKGIQAPTPIQMQGLPTAFSGRDMIGIAFTGSGKTLTFSLPLILFAVEAERRLPFEQGEGPVGLIVCPSRELARQTYDSIIAMAEALEYGGYARIRTLLCIGGIHMSEQSHVLRRGVHIVVATPGRLQDVLEKKRLGLHSCTYLCLDEADRMMDMGFEDDVRNILSFFTRQRQTLLFSATMPKKILDFAAQSLFDPVIVNVGRAGAASLDVVQEVEYVSQESKMTQLLEALQKTAPRVIVFSDNKNEVDDIHEFLLRKGVEAVAIHGSKTQDEREYAIESFKSGKKDVMVASGIASKGLDFSNIQHVINYTMPKDIEDYVHQIGRTGRSGKTGVATTFVNAQTPQSTMLDLKYLLLEAKQHVPSFFDALQDPLAGRNAPRTGCAICGGLGHTVIHCPKLEEHQRRLTSHMSHGGGEQGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0Q3</accession>
    <name>A8Q0Q3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731067.1">
        <property type="nucleotide sequence ID" value="XM_001731015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0Q3"/>
    <dbReference type="STRING" id="425265.A8Q0Q3"/>
    <dbReference type="GeneID" id="5855374"/>
    <dbReference type="KEGG" id="mgl:MGL_2066"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2066"/>
    <dbReference type="InParanoid" id="A8Q0Q3"/>
    <dbReference type="OMA" id="KNIANTW"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="254" mass="28904" checksum="B462D33B37E47CCE" modified="2008-01-15" version="1">MSDWENDDNVQPQAPAFVPRRRFEDEDLEDDDVKDDWEEEDEEPKPAPAPAPEPKKRLSVKQKIAEKEAMKQNNTGNDFDDWELEQPQENEDERRRREKEAQIRSDLDNAATLLGSTSLDAKKDNLAVDSQTVSLSDAKPSSKEDWEAFAKSLYDKLILPKASRPGFDKHFFPKMITLLTTNGLRDVDMRKGSTKLRELAEAKVKADKDMKRTGGNLRNLQNAKPKQVGTSSAKNTFDLKAYGDEALDDDLDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0R5</accession>
    <name>A8Q0R5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mo25-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731072.1">
        <property type="nucleotide sequence ID" value="XM_001731020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0R5"/>
    <dbReference type="FunCoup" id="A8Q0R5">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0R5"/>
    <dbReference type="GeneID" id="5855379"/>
    <dbReference type="KEGG" id="mgl:MGL_2071"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2071"/>
    <dbReference type="InParanoid" id="A8Q0R5"/>
    <dbReference type="OMA" id="HYNEFTR"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="30433" checksum="C575FB71252AE4FC" modified="2008-01-15" version="1">MMECLLTVMPRLEFEARKDIVQIFVALLQRSIGSRRPTVEYVWTHPAILRMAIRGYDVPDIALNTGIILHEMLQYELLAKLFLYSDDLYRFPQYIETTSFSISCDAFKNLRDALLCHRSIAAEFLNMHYDRFFHMYTQLLDSQNYVTRRQSLKLLGELLVDRAHYATMIRYVSDEENLKRIMNALRDRSKHIQLEAFHVFKVFVANPKKTPAVESILRRNRSRLLTFLQGFLPDRTDESFIDERQYIIHIISAMPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q166</accession>
    <name>A8Q166_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730743.1">
        <property type="nucleotide sequence ID" value="XM_001730691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q166"/>
    <dbReference type="FunCoup" id="A8Q166">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q166"/>
    <dbReference type="GeneID" id="5855050"/>
    <dbReference type="KEGG" id="mgl:MGL_1742"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1742"/>
    <dbReference type="InParanoid" id="A8Q166"/>
    <dbReference type="OMA" id="FMSIPYE"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31662" checksum="C2C7B788B601DA6F" modified="2008-01-15" version="1">MVDEHTAVLVIGIGGPTNSGKSTLAKNLKAILDPTGEDASPIVSVDLLHQDDFCPPKDQIPWNEKWQVQDWDTPQGSSDYSRLERVIQYMRVHKKLPADFQSFEYRRSNYTCTLDATELAKQRKRFHEELHGQTLRASRDGQQAPRIAILLVEGFLLYYSVAVRKLLDVRLFLRISRATMHQRRMERANYVLDDGEVWEDPPFYFDEIVWPAYMKASSHMFENGDVERGAPIVPSGHGFISQDGGPLRDLQVLEVEHCTKKQVTLAATDHIHAFLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q183</accession>
    <name>A8Q183_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1749</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730750.1">
        <property type="nucleotide sequence ID" value="XM_001730698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q183"/>
    <dbReference type="FunCoup" id="A8Q183">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q183"/>
    <dbReference type="GeneID" id="5855057"/>
    <dbReference type="KEGG" id="mgl:MGL_1749"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1749"/>
    <dbReference type="InParanoid" id="A8Q183"/>
    <dbReference type="OMA" id="IELPQHM"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="785"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="850" mass="95051" checksum="A6B1380CDD931911" modified="2008-01-15" version="1">MNFVDPIEITRKVIDGIYEGVTTVELDNLAAETAAYKTTTHPDYAVLAARIAISNLHKETKKSFSQVIQDLHDYVNPKTGRPSSMISEETFNTVMKHRELLDSAIIYERDFHYNFFGFKTLERSYLLRINGKVAERPQHMLMRVAVGIHGEDIESAIETYNYMSEKAFTHASPTLFNAGTPNPQMSSCFLVSMKEDSIEGIYDTLKTCAMISKTAGGIGLNIHNIRGTGSYIAGTNGVSNGIVPMLRVFNNTARYVDQGGNKRPGAFAIYLEPWHPDVFEFVDLRKNHGKDEVRARDLFLAMWVPDLFMKRVEKNEDWSLMCPAEAPGLADCYGEEFEELYERYEREGRAKRSVKAQKLWYAILEAQIETGNPFMLYKDAANRKSNQKNLGTIKSSNLCTEIMEYSSPEETAVCNLASIALPTFIEGTGASKIYNFQRLHDVAKVVCKNLNRIIDINYYPVPSARRSNMRHRPIGIGVQGLADAFMIMGYPFDSQEARRLNLQIFETIYHAALERSCELAEQYGTYETYQGSPASQGILQYDMWNRTPTDLWDWASLKAKIAQHGLRNSLLLAPMPTASTSQILGFNECFEPYTNNIYMRRVLAGEFQVVNPWLLRELVELGLWNDSMKQKIIAHGGSIQNIPGIPDHIKALYKTVWEISQKVIIDMAADRGAFVCQSQSLNIHLSAPSFGQLTSMHFYGWKKGLKTGSYYLRTRPAASAIQFTVSNEEIAEAKATRKAVNAQRAAAASAASTMASTQAPTPSSVVTEPRPVVDRGYESMVQGVGRLGVDGTVTEDGPGKDRPAADASGQPSEDEGFLAAQERQRRRQEEADERLACSLENKDACLMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1V1</accession>
    <name>A8Q1V1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1843</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730844.1">
        <property type="nucleotide sequence ID" value="XM_001730792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1V1"/>
    <dbReference type="FunCoup" id="A8Q1V1">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1V1"/>
    <dbReference type="GeneID" id="5855151"/>
    <dbReference type="KEGG" id="mgl:MGL_1843"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1843"/>
    <dbReference type="InParanoid" id="A8Q1V1"/>
    <dbReference type="OMA" id="WRWTVSP"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="181"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="427" mass="47600" checksum="27C4D33DEF754BDA" modified="2008-01-15" version="1">MSTTSNGRVLLAYSGGLDTSTILAWLIDEGYEVIAYMANVGQEEDFDSVREKALKCGAKEFILDDVRREFVEELIFPAVQANAIYEDVYLLGTSLARPVIARGMIETAEKMKCEYVSHGCTGKGNDQVRFELAFYGLKPDIKVIAPWRIPKFYQRFAGRSDLLEYAASKGIPVAQTKAKPWSTDENLFHISYEAGILEDPNTTPPEDMWKLTQSPQNAPNEPEKISIEFTKGIPTRLTVHATGNVYTDACDLFLQLNTLARKHGIGRVDIVENRFIGVKSRGCYESPGATILRAAHIDLEGLTLDREVRRIRDQIVTTKLSEILYYGFFFSPESQYVRSCIPPSQLTVNGTVKLSLFKGHVSIDGRSSDELLYDEKFTSMDELGGFEPEETSGFIAVQSIRLKRFGLGQSVKGLAGTDPKKAYAIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q201</accession>
    <name>A8Q201_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730866.1">
        <property type="nucleotide sequence ID" value="XM_001730814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q201"/>
    <dbReference type="STRING" id="425265.A8Q201"/>
    <dbReference type="GeneID" id="5855173"/>
    <dbReference type="KEGG" id="mgl:MGL_1865"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1865"/>
    <dbReference type="InParanoid" id="A8Q201"/>
    <dbReference type="OMA" id="WRMKLQE"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="2">
        <location>
            <begin position="643"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1043" mass="114618" checksum="ACD78DAED6FFDE1F" modified="2008-01-15" version="1">MPSPLRARSSLPELGKENVPPLVRKSPRKQDGLKRKKAKSFGGGASGGTVGGVSPKSKERAAPRKSAIRATPQVFQSPTNLEPNPEHEHIRMPGQDMQNVVAKTEQDGLNDLLDERLRSPGLPNPFTALFRPSSASPAKNEAHTISVPAKQPMEADRKRRRVTFSAYQEQTDFEQDEPTMSIRPAQVHDRNALVERGSPVPNASSSSPTQAMSSASSDMDDSEVSMSLDSDQSGMEMTTTWNMRGTQEQEQELELYDHQDFKDESAGEESVDMELTGRFSAVNDSTARDTSMLLNTSHVSSINMSTSPRKPHASPEKHGIAPPHKSVVSPLKTLPSPYNPFSISHQSILSAKQPDASPSKSRPALNAPRASSLKSLSPPPIAPRSPLSKTRPSLGTPQVSFNKSSASPRKPRSSMGSDTTQTMDLTMAFSPASDASESSDTTLDSDAERSAMEMTEMWGRFAEDATRKREAAEAAAATVAAPPPVVSVPRSPSPTSPKRSPVRRQTMFLSPDRSARTGSAGSTPKAEKRAASIPPAWESMPSTPSTPTRFRQSLRGGVPSPSYQHSPPRRALTTPPIGSPARSAATDRDMSPTPLSPPIRGAAQFRMSDAYSQQAAWPRSPFIHSLLRQRGGRMSQSNVSPRSDGDLTDRDEETSFHMQLADFLSVIGLKFHEDMTASRTHAERPREAAAAGGTMHPTTALQYAKMAGAAAPMLQALRNACQELKQHVEDGRVRLHAMEQDFYARPPAFVQEWGQLEDDDMRRSMKGQLNVHKQAARAAAMHDYYGWRTDMQYDDDMVLALVQHRDALRADQERVLGKRATLEDELLPTLRERHAELKQRVDEARARQEAIRQCDPEELKQLHASIDEQDHVLQTMRAKQRDVADQLARVRSRVDESYAKREQTEELIRAARVVSDQIHGCTPGEAVRLGRRIRQLETLLQWSLTNKTSTLLQLVFARTLNVAIELDGRRGGHSGTVKRVAISPARPVEASPMHMAAICVIRSHLEAHTPACVPDVLRTTARSGTYTCRHALRSIDCACMCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q255</accession>
    <name>A8Q255_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730686.1">
        <property type="nucleotide sequence ID" value="XM_001730634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q255"/>
    <dbReference type="FunCoup" id="A8Q255">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q255"/>
    <dbReference type="GeneID" id="5854982"/>
    <dbReference type="KEGG" id="mgl:MGL_2140"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2140"/>
    <dbReference type="InParanoid" id="A8Q255"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="83" mass="9364" checksum="C6F16A95A18E0B20" modified="2008-01-15" version="1">MSSSSLPEGRHSRILFVKNLNYNIHGADLYELFGRYGAIRQIRLGTSQQTRGTAFVVYEEANDAKNAIASLNGFHLMERYIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q256</accession>
    <name>A8Q256_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FIST domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730687.1">
        <property type="nucleotide sequence ID" value="XM_001730635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q256"/>
    <dbReference type="GeneID" id="5854983"/>
    <dbReference type="KEGG" id="mgl:MGL_2141"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2141"/>
    <dbReference type="InParanoid" id="A8Q256"/>
    <dbReference type="OMA" id="LHRSAFN"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00897">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIST" evidence="1">
        <location>
            <begin position="22"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="436" mass="47510" checksum="73C823FC1F72DBE3" modified="2008-01-15" version="1">MASRADSLVPAIKKSLRAWPRTPDHLCLFSISKNMPQSVMTELVSSISHTQQTHVGTLSEPLHPGTLSQHASSMPAPLYSVALARIPASQAIAFRSVIPGAPRIAVGRWPEQKETWHADPTARTKHLDETGHWAPLWGRQNVERRIPVELETIARNPSDIHAFLLFSDAFPQGLLEGLDSHFPHTSLLGTVAAYTPFETGREHTLFYGTSTQGVYEKGAVGIAFRSSARLERTLGGLVPIGPRLAITGAQGNIISSLDHHNATQQLIRLITGQQKARGEAVQDPQAVRAMASHVRKDDDVFLGVYAHPEDDMPLTITRIQSGHPMRGTLCIDADIELGGPQKYAQVYRNGHERGVADPFLPASIRYIVASGNETATALQKAKTHLTRMDNDLASLEHTFLVASDKGWFGRASTSFSSPAHTYAIPHTSASLTHSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q296</accession>
    <name>A8Q296_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730719.1">
        <property type="nucleotide sequence ID" value="XM_001730667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q296"/>
    <dbReference type="FunCoup" id="A8Q296">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q296"/>
    <dbReference type="GeneID" id="5855025"/>
    <dbReference type="KEGG" id="mgl:MGL_2173"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2173"/>
    <dbReference type="InParanoid" id="A8Q296"/>
    <dbReference type="OMA" id="FEKWPFR"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027833">
        <property type="entry name" value="MtTFB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="386" mass="43865" checksum="6DA646ED2CAB73C9" modified="2008-01-15" version="1">MPHPSRWKDLFAFSKEQGARYRYFVANRGTVQGIVSQLGLDEREAQGIKTTIVEAYPGPGTFTREFLLHPNVERVVSMDNVPMFLEQLEHLREDPALKHVQHKLGIIPESGYAWDSYEMMVEQGLLRHLEGRVPKLGPQAPPMDWHATSPILFFAQLPNTVHGEQLFAQIINAISSRFWLFKFGRVKLVFVCGETVSLRSLATPQESRTRAKLGATVQCLSTPRLLLPAHDLEPYADHMYPPTPSVGPRVPVTSVFIPNSNISTGLQKRKLTVLEIDPLPEPLIDQRDMDAFEFLTRNMFVLKSKTVLEGLKHVVPGAHNVLRLVAPEHPRMKDRPDDVVLPTTPIVELTNRQWASLAEAFEKWPFRPEVFVDEGRVRRGLSDYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2A5</accession>
    <name>A8Q2A5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730725.1">
        <property type="nucleotide sequence ID" value="XM_001730673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2A5"/>
    <dbReference type="GeneID" id="5855031"/>
    <dbReference type="KEGG" id="mgl:MGL_2179"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2179"/>
    <dbReference type="InParanoid" id="A8Q2A5"/>
    <dbReference type="OMA" id="TTHITHE"/>
    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35750" checksum="54ECE07518346089" modified="2008-01-15" version="1">MSNVIKKVFNTDKAEGEAHKAQDAVQGAENNAQHHGEGFLSEGKEKLSHMMPHHHHHQASTPSVQGVESNVVGQASAGVPDAESLRAANVSAVPKSESDAFGRSGNMTQTTSVNSGVNVAAGNVDQDVQHLAPVTRHVHHRHEIEELLREREHHIHQHHIQHHVQPVLESEHLAEQIHSRVVPTTTIREVHANTDKDAALMRAVAGNPKDTFTQAATDRSVIDKGETVREIVHHHIHNIVQPIIEKETHEYHRIRTTIPTTHITHEAPIVHESTAHQPIRKEDFIKGGGVLSSTTRSIEEAGLLNLGTNQRSVEGEAYNGGAPLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q391</accession>
    <name>A8Q391_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730542.1">
        <property type="nucleotide sequence ID" value="XM_001730490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q391"/>
    <dbReference type="FunCoup" id="A8Q391">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q391"/>
    <dbReference type="GeneID" id="5854849"/>
    <dbReference type="KEGG" id="mgl:MGL_2338"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2338"/>
    <dbReference type="InParanoid" id="A8Q391"/>
    <dbReference type="OMA" id="LCIFARH"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000091">
        <property type="entry name" value="Peptide alpha-N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="209" mass="24132" checksum="6497AFF9BE7D4435" modified="2008-01-15" version="1">MDRRTELPVRVETYRNEEDLKDVIRLIEKELSEPYHIYTYRYFLNAWPELSFLAWAGSEAVGVIVCKLDQHMRGSRLMRGYIAMLSVDPRWRGLGIAKRLVKAAVEKMREKGADEVMLETEVTNTAAVRLYENRGFFREKRLYRFYLNGNDAFRLILPLIPISPPTFKSTSSQQLLTLDTQPLSSVAAPPPLPPRPPSLLDRSILDHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3E6</accession>
    <name>A8Q3E6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730578.1">
        <property type="nucleotide sequence ID" value="XM_001730526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3E6"/>
    <dbReference type="FunCoup" id="A8Q3E6">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3E6"/>
    <dbReference type="GeneID" id="5854885"/>
    <dbReference type="KEGG" id="mgl:MGL_2374"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2374"/>
    <dbReference type="InParanoid" id="A8Q3E6"/>
    <dbReference type="OMA" id="PGDMATD"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="265" mass="28303" checksum="391B5F97052C3BAD" modified="2008-01-15" version="1">MTDKKVVLVTGASRGIGLAAVRRLVYGTPSIPASRVVTLSRTLTEDLAALAREKPDDLVTVQGDVTSEKDNLSARDEALKRWGRLDALILNAGIVDHQMCADLTPERFLHVLNVNTVSLALTVRIALPELRKSHGSVVFVSSGSATSNYSSWAAYNASKAAMNAYARTLANEESDIACFSIRPGVVDTDMQVLIRSTDQMPSAQHAKFLGLHKEGKLVPADKPAQVLAALATKGTRSSPTLPDGTHPGALGAFMSWDDPVCQDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3V9</accession>
    <name>A8Q3V9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730091.1">
        <property type="nucleotide sequence ID" value="XM_001730039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3V9"/>
    <dbReference type="STRING" id="425265.A8Q3V9"/>
    <dbReference type="GeneID" id="5854408"/>
    <dbReference type="KEGG" id="mgl:MGL_2473"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2473"/>
    <dbReference type="InParanoid" id="A8Q3V9"/>
    <dbReference type="OMA" id="VRWSKDQ"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000624">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20921" checksum="81BF69E6093AF940" modified="2008-01-15" version="1">MGLTFSSLYESLFWWRRQAPMRILMLGLDSAGKTTILYRLQLGEVISTIPTIGFNVETVEYKNIQLQVWDLGGQSSIRPYWRCYYADTSAIIYVVDASDQERLPTARAELLAMLAEEELAKCKLLVFANKQDLPNALDEVQIGKAIGLDELRDRQWSIWRCCAKDGTGLQEGLDWLVDALRANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q409</accession>
    <name>A8Q409_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_2486</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Also interacts with RBP1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730104.1">
        <property type="nucleotide sequence ID" value="XM_001730052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q409"/>
    <dbReference type="FunCoup" id="A8Q409">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q409"/>
    <dbReference type="GeneID" id="5854411"/>
    <dbReference type="KEGG" id="mgl:MGL_2486"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2486"/>
    <dbReference type="InParanoid" id="A8Q409"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP42890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="187" mass="20862" checksum="712DE1081F0C460A" modified="2008-01-15" version="1">MSSSGTGGKSGPTTGQKPEARKPVSQSVRAGLQFPVGRIHRHLKNKSQNNIRVGAKAAVYLSAILEYLTAEVLELAGNASKDLRVKRITPRHLQLAIRGDEELDSLIRATIAGGGVLPYIHKSRKCLRPQLTEQRSYQDAWEEEELIRLDVPIPAFLLPFFCRCVFLSFSLSLRVCMHVCILIERSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4E1</accession>
    <name>A8Q4E1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730147.1">
        <property type="nucleotide sequence ID" value="XM_001730095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4E1"/>
    <dbReference type="STRING" id="425265.A8Q4E1"/>
    <dbReference type="GeneID" id="5854454"/>
    <dbReference type="KEGG" id="mgl:MGL_2529"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2529"/>
    <dbReference type="InParanoid" id="A8Q4E1"/>
    <dbReference type="OMA" id="FKCHACY"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7600" checksum="94B963B89B24012E" modified="2008-01-15" version="1">MTKKKKATQLDAWCWYCDREFEDEKVLIEHQKAKHFKCSFCPRRLNTAGGLAVHLGQVHKAQPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4T9</accession>
    <name>A8Q4T9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730254.1">
        <property type="nucleotide sequence ID" value="XM_001730202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4T9"/>
    <dbReference type="FunCoup" id="A8Q4T9">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4T9"/>
    <dbReference type="GeneID" id="5854559"/>
    <dbReference type="KEGG" id="mgl:MGL_2636"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2636"/>
    <dbReference type="InParanoid" id="A8Q4T9"/>
    <dbReference type="OMA" id="FAMVNSW"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14528">
        <property type="entry name" value="PFA-DSP_Siw14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000024">
        <property type="entry name" value="probable tyrosine-protein phosphatase At1g05000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="96"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="287" mass="33255" checksum="025B20D5E4F7669B" modified="2008-01-15" version="1">MASAIETALPDVPIDYTALLCRKPEDHVSVPDPPVRLEFLRRILRENEARNAHKCEAESRRSQDSSTRDEHDAAAISNASAQVDESHDKELIPPDNFAMVNSWVYRSSFPKKKHFQFLKTLGLRSVLTLILEDYPEQNIQFLDENGIRFFQYGIPGNKEPFVQIPSETITAALATILDRRNHPMLIHCNKGKHRTGCLIGCLRKLQQWSLTTIFDEYRRFSFPKSRSMDQEFIELYSEQAVWPQIQPEWLPKWTVLGRREILSRVIWEKNDASTENKNDGDDEVRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q502</accession>
    <name>A8Q502_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI inositol-deacylase</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2686</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730304.1">
        <property type="nucleotide sequence ID" value="XM_001730252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q502"/>
    <dbReference type="STRING" id="425265.A8Q502"/>
    <dbReference type="GeneID" id="5854609"/>
    <dbReference type="KEGG" id="mgl:MGL_2686"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2686"/>
    <dbReference type="InParanoid" id="A8Q502"/>
    <dbReference type="OMA" id="NMITLAT"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="13">
        <location>
            <begin position="13"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="264" mass="29436" checksum="FAE18E0D6EDC4EF0" modified="2008-01-15" version="1">MPNKWKEQPLYSMPVLFIPGNAGSFAQVRSLASSAFYQYWTRNGHDPRPDMEDVLGPTVWYTVDFNEDFSAFHGGTLEDQAFFVNEVLRYLRAQYDSVPPEDDAASSRRFSDDRNTTIGIVGHSMGGIVARLAMTLPNYPVSSVDTIVTLSTPHAYPPVPFERSMDRVYDRIHRHMRDEPLIISLAGGLLDTQLSSDATSLTLDGHGSPMSHLSSFTTSAASLWSSTDHLAIVWCDQLRYRIARQEPSARDGGLDANIDGIYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q517</accession>
    <name>A8Q517_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2698</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730316.1">
        <property type="nucleotide sequence ID" value="XM_001730264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q517"/>
    <dbReference type="FunCoup" id="A8Q517">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q517"/>
    <dbReference type="GeneID" id="5854621"/>
    <dbReference type="KEGG" id="mgl:MGL_2698"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2698"/>
    <dbReference type="InParanoid" id="A8Q517"/>
    <dbReference type="OMA" id="MLYFRVE"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="76"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28056" checksum="74B71401B8E22521" modified="2008-01-15" version="1">MPAAALFLATGFALYYYFQHEKAKLAESKKKKQEDQVIGRPRIGGPFSLVSSTGHPFTDKDLLGSFSLIYFGFTNCPDICPEELDKMSSVVNEVAKTHGTVINPVFITCDPARDRVPYVAEYIADFHPRMIGLTGTYDAIKQACKSYRVYFSTPPGADPTSDYLVDHSIFFYLMDPEGKFIDAFGKSSTMEEVRDKVLDYIARWKAAGLPLVEANAKEKAATDGRSKASEASLFEEPSSVPSVPPAVLPAGDRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q526</accession>
    <name>A8Q526_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730323.1">
        <property type="nucleotide sequence ID" value="XM_001730271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q526"/>
    <dbReference type="STRING" id="425265.A8Q526"/>
    <dbReference type="MEROPS" id="C48.A09"/>
    <dbReference type="GeneID" id="5854628"/>
    <dbReference type="KEGG" id="mgl:MGL_2705"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2705"/>
    <dbReference type="InParanoid" id="A8Q526"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="352"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="438" mass="48989" checksum="C00D6B0B1B4D3BB8" modified="2008-01-15" version="1">MGASSPKRRAIEEKPLRPLPSSAMASPYRIPISPASFYASPTHSTQQSHSQDTLSHDAQPKQTSPNLHNKTGDDSRDEIDFLTPATSLHDRMRGKAPSNSSQAHMGPTAAMGRTSALTKCVNVRLRAVFVGQEYASRNEGVEVAAFQTHLTLFHRTTACAKVAFRDVLDTQLGGKEHALIAMSIKQKCSSARAIASLCGEAALDPCCLYMFVEPNDTSWPLLFDQVCTYTHAEKLTESACMALFEASLRSNTKTLRIPSSPSAHVRKPTPIVIGERRTAALEKARSDESTKPTCATGAAELVRSSTLTDSITAESARPIRYTRERTRLEEQQRKASQSKPILRYPASGPFAVTLLQSDVERLQEGEYLNDTLIEFGLRFLLERIKQREPNLAQQIHVFNTFFYHKLTESRDRSKTYEHVRKWTNKVNMYVFITYSRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5L1</accession>
    <name>A8Q5L1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729805.1">
        <property type="nucleotide sequence ID" value="XM_001729753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5L1"/>
    <dbReference type="FunCoup" id="A8Q5L1">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5L1"/>
    <dbReference type="GeneID" id="5854106"/>
    <dbReference type="KEGG" id="mgl:MGL_2791"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2791"/>
    <dbReference type="InParanoid" id="A8Q5L1"/>
    <dbReference type="OMA" id="MCESAKG"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="3">
        <location>
            <begin position="22"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="384" mass="43188" checksum="5CCEB3892E5F9FF5" modified="2008-01-15" version="1">MTTEFKTSDACLEGILMHEEPFESVSIDSNRQQDQSENREMDILSIYDALREILVDHNQNASVQLQHQLKRGSFSRKLLIFEAMSSLMIPLAINQFGHFLVNRAIGYCADTAQHLSGAFVLLALSPVGVHVVSHVLDGPEVWKIQVVRELLQESLLITLTTQHSQCLWHKILQMRWTDPSMPLEIRESIHDALRGRWASFANTETGSTLCQHLYDSKILCDMDDGMQELLQELVGCVCDPWGVWVIQHLLEHGSVSIRECIAQCFIVSAATVSLSSYGSKAVQCALRYCGESFQNQYADVLCRVVRAGHDNVRSGGARRPLLVDVAATQHGLPILSLLLTTILRAKRTHLVDIIRVNASYLRRNRSGTRVVQLCGMYAPRKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5S1</accession>
    <name>A8Q5S1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729824.1">
        <property type="nucleotide sequence ID" value="XM_001729772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5S1"/>
    <dbReference type="FunCoup" id="A8Q5S1">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5S1"/>
    <dbReference type="GeneID" id="5854131"/>
    <dbReference type="KEGG" id="mgl:MGL_2810"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2810"/>
    <dbReference type="InParanoid" id="A8Q5S1"/>
    <dbReference type="OMA" id="WIIDAVI"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26352" checksum="95201C7D4DF7C039" modified="2008-01-15" version="1">MFLKSTRHSQSLGTITGIWLLPIIAVIVAGGSGSIISESLPAKHAKITIVLSYMLLGGGLCVTFFGMTLYYARLAFHKVPAASLIITVFIPLGPCAQTAFAFLRLSTAISELYSDFGQPLIGSRLLSPEDTRIMNLAIQGCSILMAVGFWGLSFFWLSLGLSIWIDTWIVTKLKFNPGWWGAVFPLGIYALSTIEMGTAFDSGAFKKLSIVFGLCAILVWLLMASLTLYNVARGKVYVCKMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5X8</accession>
    <name>A8Q5X8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729842.1">
        <property type="nucleotide sequence ID" value="XM_001729790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5X8"/>
    <dbReference type="FunCoup" id="A8Q5X8">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5X8"/>
    <dbReference type="GeneID" id="5854149"/>
    <dbReference type="KEGG" id="mgl:MGL_2828"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2828"/>
    <dbReference type="InParanoid" id="A8Q5X8"/>
    <dbReference type="OMA" id="RQFITHG"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000004">
        <property type="entry name" value="40s ribosomal protein s9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="114"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="202" mass="23229" checksum="8B3BDCD83E0D916F" modified="2008-01-15" version="1">MPTATRHCKGAPRNHSKTYKVPRRPFESPRLDAELKLAGEYGLKNKKEIWRIALTLSKIRRAARELLKLDEKDPKRLFEGNAIIRRLIRIGVLDESRMKLDYVLALKIEDFLERRLQTQVYKSGLARSIHHARVLIFQRHIRVGKQIVTSPSFIVRLESQKHIDFALNSPYAGARPGRVKRKRTKAAEEAAGGDEEGGEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q619</accession>
    <name>A8Q619_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729856.1">
        <property type="nucleotide sequence ID" value="XM_001729804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q619"/>
    <dbReference type="FunCoup" id="A8Q619">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q619"/>
    <dbReference type="GeneID" id="5854163"/>
    <dbReference type="KEGG" id="mgl:MGL_2842"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2842"/>
    <dbReference type="InParanoid" id="A8Q619"/>
    <dbReference type="OMA" id="IILDFTT"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="134"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="579"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118365" checksum="849D7AB46E8EFFAC" modified="2008-01-15" version="1">MDVALQAYVDGTYASVPPSVCEDVEKGKHSLLDLIKNLGTYLTSDDEVVRARAIALLSCVIEHLASQRADHTHVQLRRQTIRTLTEFFSSKISDAVIVGDIMSQRANDAPVVPATAPRAAIKAEEDRTLRADQMLYDCLRTLLVLSSVGFEENEARSRDAFGGEDARTAAKALFSLDLHKYPQPLRFVVGQLLDALVTRHLTALASMRTGPDAPDGSAFVHGYATLVTGEKDPRNLLLLFGLARVLLLEWDIGPKEADAMYNILFCYFPISFRPPPDDPYGITPDQLKKALRACLSASSKFAPMAYPLLLEKLSATGGSSKIDTLQTISACLPVYGRAAAIEHGSDLWTYLQLDILQPTDEQIIPFAQDTLTAFLRVICTDQWEPLAQTILQTSLDLCQSTSQSQARDSMRILQCFVNACHVTYTQATNQFMRIMLRQWQDVSSDVAHQRTELRSMYLNLLITAQDSYEKHGRPLDAFHEQLVYIYTSPSLCEREHGLRGLQCLFQLPGLLTPDDRLRATRCLQNVLLEAPKALQPHALKGLEIVLDMDRSLIQSETVPFLLSRLPTHVQRPPLHVPPILSAVSCLCTTSELFDAWQARAMSLLKTLSTSADDLAHVGYMCALLATLQVTIERKMEAKHEDLPRLAQGLTIRLLDWLHDPNGIATHQRLVMQQASDLLLVLVPHIPATNVTELVGRASRDIRVGHTEPDAFSHVHDRLLPCAAIITGLSRQATLPQASEWLRTVVSWIQHSAMEDWYAKSACFLLCALANKFVEPEPEYLATFWATVPTIEARPRHRLLCLEAWLWLARGWMARGVAFGTDMVHTLLTDMLRDERVGVSAARALHVLADHDHLLTRSRGFQVRILYKQRILDSLLQSLMKTYREHRDETQRAPCLVAIATILPALTEASLYMYVETLLPILSHALCLSDARVRTSCASFVTNVAQRLANASDASTTATPTTQEHDADRALRNALIEHLPVLVPRLLANAEPGADHSISVRLASLQALHALVDALPHDCLFIYRRQVVQTLGRHDKGVDDKVRSVRAAAVDCRSAWYRVQALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q668</accession>
    <name>A8Q668_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729878.1">
        <property type="nucleotide sequence ID" value="XM_001729826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q668"/>
    <dbReference type="STRING" id="425265.A8Q668"/>
    <dbReference type="GeneID" id="5854185"/>
    <dbReference type="KEGG" id="mgl:MGL_2864"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2864"/>
    <dbReference type="InParanoid" id="A8Q668"/>
    <dbReference type="OMA" id="DKVITHK"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="213" mass="23379" checksum="76D07CF40F413A61" modified="2008-01-15" version="1">MATQGLEGAATSTQAPAVTVKNLEEALHLLKMQPNHYVVASIAGRTFVLSSSDVITVPRLPGVKLGDILELDLVHEVGSRDFTLRAQDPAHGARNPEGGRFPLVLLRSRTDNSHCVRVRTDELVKSEEAHSIVPFSSSWAAQLIPTGMAHVGAALSSDVVQVQCVVIEHAKGPLERIEKFKRRKGYDKVITHKQPYTRIRVDTIKLGPRERSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q685</accession>
    <name>A8Q685_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729895.1">
        <property type="nucleotide sequence ID" value="XM_001729843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q685"/>
    <dbReference type="STRING" id="425265.A8Q685"/>
    <dbReference type="GeneID" id="5854202"/>
    <dbReference type="KEGG" id="mgl:MGL_2881"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2881"/>
    <dbReference type="InParanoid" id="A8Q685"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11287" checksum="57700929852B0F37" modified="2008-01-15" version="1">MIRILVQVVLSSYKSLLLCVIQFVVQGVLSVLDAATHAVSHAVHDAAQFLRAILDTLFQAADGVADIMTDTINGILGLFGQQKIPTHSWSEPAALRYVTLRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q698</accession>
    <name>A8Q698_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729908.1">
        <property type="nucleotide sequence ID" value="XM_001729856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q698"/>
    <dbReference type="STRING" id="425265.A8Q698"/>
    <dbReference type="GeneID" id="5854215"/>
    <dbReference type="KEGG" id="mgl:MGL_2894"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2894"/>
    <dbReference type="InParanoid" id="A8Q698"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CREG-like beta-barrel" evidence="1">
        <location>
            <begin position="65"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="174" mass="19807" checksum="B0F5DB61E566BEDC" modified="2008-01-15" version="1">MNYRLTSVYSSEQWRLALRPNTTVTLAIASSPDVHVVDPRHAYISPVGRLQWLKDRPLWRRGMASKGRMTMYGRMHRITRSDDVASLSNCFVKHHPDAEAWKPGASESPHTAFWVRFSPHEIHYVGGFGDEHFIGAVDMQQYRSYDVRIDADATASSLSPPSRSLELPVVHFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6L1</accession>
    <name>A8Q6L1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730012.1">
        <property type="nucleotide sequence ID" value="XM_001729960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6L1"/>
    <dbReference type="STRING" id="425265.A8Q6L1"/>
    <dbReference type="GeneID" id="5854319"/>
    <dbReference type="KEGG" id="mgl:MGL_2998"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2998"/>
    <dbReference type="InParanoid" id="A8Q6L1"/>
    <dbReference type="OMA" id="GHTSHHE"/>
    <dbReference type="OrthoDB" id="10412134at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725157" description="REJ domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="61323" checksum="10765F2794DF037C" modified="2008-01-15" version="1">MKFSVFVLTAISMAAISVHGVPIDVRGEHAHSSSSSAGPTSVEVQTENTNNLGLGLNNLQQTADGQHPVILSGVANGLAGFPHLSSKSKSQSQGHVKTIYHNDNVLGTVPTLEEFRSQGHQRVIEQLKAETSQGSLSPEQLARVSSSLRVLTASKTATSTSSSSASKATKTGHTSHHEKHSKRPKHSNKKNGSQRSYHANHVSKARSSRNSFMRHASKHPKTTLSKQAVSPMPTVSLPSKSSALLASISSVAQSLLKRDENVQSNVFEAVQSISDGSTVADVTSSTATATTRVDTASAKPTSLASKKRKGMRRCRPRSSKKVADNNNNINAYQTDDSDNSSPSSTSNSKSGKSDSSSSSHSSKHHDPKSTSMSSSYSSKHHGHKSNSMSSSHSSKHHGHKSNSMSSSHSSKHHGHKSSSSSSSPSSHHHHHHHHHHHHHHHHTNSSSSSTPSGHHHHKTSSSSSSRSSPSSSSSSSKSHKMRSSSSSNSPSSSSSSSKSHKTRSSSSSKSSSTSSDRSSTSPTSSSSSRAKSTTSSSSSNEHGVTVSQGSSEDLHGAKTMSFSDDDSVGQEASDIFDQLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6Q6</accession>
    <name>A8Q6Q6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">MGL_3033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730047.1">
        <property type="nucleotide sequence ID" value="XM_001729995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6Q6"/>
    <dbReference type="FunCoup" id="A8Q6Q6">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6Q6"/>
    <dbReference type="GeneID" id="5854354"/>
    <dbReference type="KEGG" id="mgl:MGL_3033"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3033"/>
    <dbReference type="InParanoid" id="A8Q6Q6"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="245" mass="26643" checksum="71295A5757D4D526" modified="2008-01-15" version="1">MALRCQFENSSEIGVFARLTNWYCLVAVGGSANFYTTFEIELADLMPVVHCTIAGTRLVGRLTVGNRHGLLVPMTTTDQELQHLRNSLPDKVAIQRVEERLSALGNVIACNDYVAIVHPDLDRETEEIIADVLKVEVFRQTVGDNVLVGSYATMSNQGALVHPKTSLQDQDELSSLLQVPLVAGTVNRGSDLIGAGLLVNDWVAFVGLDTTATEVSVIESTFRLQNQEAGAVVDQLRDALVDSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6Q9</accession>
    <name>A8Q6Q9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730049.1">
        <property type="nucleotide sequence ID" value="XM_001729997.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q6Q9">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6Q9"/>
    <dbReference type="GeneID" id="5854356"/>
    <dbReference type="KEGG" id="mgl:MGL_3035"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3035"/>
    <dbReference type="InParanoid" id="A8Q6Q9"/>
    <dbReference type="OMA" id="NQKLWLM"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="105"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="610"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="926"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1248"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1248"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1425"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1548"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1570"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1588"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1613"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1636"/>
            <end position="1659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1673" mass="187637" checksum="1CF9713936838FE3" modified="2008-01-15" version="1">MATTKCDANAKPTWLVQTLSTLSDTNTPSTVRESLAQQWASDPSSTRLAVTHLVRECLQGASISSVHAAQTLDVHDAAWPDALLDTLWALDWEMEARHEAGDTSAVSLDMARARLADLLHELVAQGVLERQKVAARIDAPLLGKLGMVDPSLFQRRGIQIRTATFFKQPKYNLLREENQGYASLFMSLESCVGPSLVVDDLGRVREDETAAERDARAAGWLTTMTSLVGAYNLDPARALDVALTLFCSHVVHHYPFFLSLFRQASPTWDSERITEILGFQYAHYVHPDTRESAPEELYLLTALLIRERIVSLAQMMAYIASDDAMRQLRHAYEEALTTKTASVGANALTMAAPLVDDDAPTSSPNVSASSSAPDRAASASPAAHGVHGIKLVRAMLRCGALDEVRAFIAAHPWIFGAYPSLTHAYVRLVWRRLDTPAFRRIAVLCHVPTRAQRTSTLTMFAPEPRATRTHQFVFCVGDWADAHPPFEHAEDVLPLLAPLGVYVCQDRRLLQLLCRVCANATNKTPWMHFLRTQLMPAITLADGGAPVLYELWRVLQTLPYTERYSLYGEWKQRSGKRPELRFAKMQTEREARGILRRISSDNVRASGRSFAKAAHAHPTVFFDVVLHQIQSYDNLIEPVVDAAKYLTPLEYDVFSYALLDALSQPAKERTKSDGTNASLWLKSLASFAGAFYRKYVSMDGTPLLQYLANRLKQDNVTDLIVLSELVLKMSGIEPAGELSESQMAALSGGPLLQTEAAMTLMPGSTPAAILLARNGFKKGALRLYRMLVQSRLAMPILILIAQQRQACVFTAADDAADTPIKSLSSTFDTCVAILFQYAHFLAAQGAEDHAQRVPLPADWIRRFGLDASMAFHLARPRLLWDMQQSSKSEDKDMHVDGDVEVVWHAALQSTVQGIASVMPANSISALGAPFFTTFWQLALPDVTVPMERYQQELSRLRQSIQDVDAAADLSESLKKSARVRLQESIAHLTTELKEQTLAYQATRRRLQAEKVHWFAPDVHRGQLVQQLVVHCLHPRALFSPTDAVYTAKFLRMLHTLGTPALPTLAVYDVLLTQHVASTLFLASENEARSYARFLHAILGDLHGWLQSKDLYDKEALGDVPGFSLAWEGLRGMHTRRTGDQPLSFAAFKLCMLTWHTSLHDAFASCFGSEYMRIRNAIVVLNRISGYFPLHKEHGAHLLQAVEHVVASEHRGDLKVLGQGLVATLKKQAPTWVDVSFFRPLTKEERDARARHEAALRAKAEDEQREREAKKAQEAREAQQAKEAEEARRAEEAAAAAKADEARRADEARRAEEARRAEEARRTAEEPRHVDEEPAPPHKQSRDNAKHDARAEDGIVDRDDSWRRATPDRRGSKVPSKIDRRDRDRKSEDAPSAAHDEPRELRIRGSGDTRAKDRPKDSTNDTAASRGDDSFGARHDPRPSRSEQRARHGRSDFPDRDARPPPRDARSERAGGGRWGRERERERERERHREREHYGRYDRRASDDRPYPHPHPHTDHSDDRWQETNAQWNRRRSDVSPSPAAPMQQGATDDAHRANDERGGRKRSLADRLGSSDTGTPSSDSVRIPIQAHTRTSDTQSQQGTPDMKRMRRDRMSVRSQQGASTASDDRPPDHAPNAWPERDRPARAWGRERANDMPREHRERDRRKRRAGGDEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6W6</accession>
    <name>A8Q6W6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730083.1">
        <property type="nucleotide sequence ID" value="XM_001730031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6W6"/>
    <dbReference type="GeneID" id="5854390"/>
    <dbReference type="KEGG" id="mgl:MGL_3069"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3069"/>
    <dbReference type="InParanoid" id="A8Q6W6"/>
    <dbReference type="OMA" id="HGHTIES"/>
    <dbReference type="OrthoDB" id="3358973at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="370" mass="40768" checksum="93FF57A12A721D32" modified="2008-01-15" version="1">MSAAGTDATGTLPSIVPPTCIVTDSAPEDTYALAGQGEYPQTEEQRLETRNVEEYLRRMSQRERLNRRSRLDAQNANASTSNGSSSLMRRLSSSIARVPSLRSARHTHQPGAKAGAYEMTQSNYGESPRRDTPHMPQGYGPITDESEESQFMSVNIPDATESRQELNDHTPLHTDPYASTGDVSAISMEDLGESQRPFESDTPTSPPDPYQYAPGTETALARLRSQNFPSVTVGKASNRQMQRQASMSRQTSSSAARHHTRSPIESIPEGDIDVTMVPSQMSGMHPTKDDPFQTPPYSGSLSRSSCTDLHELPLQSQTYPSAALMTTHSFRNEDTNAIDRWYWSDLLLGCGLCKTTNDEDEQAARTNPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7K1</accession>
    <name>A8Q7K1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729535.1">
        <property type="nucleotide sequence ID" value="XM_001729483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7K1"/>
    <dbReference type="GeneID" id="5853841"/>
    <dbReference type="KEGG" id="mgl:MGL_3079"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3079"/>
    <dbReference type="InParanoid" id="A8Q7K1"/>
    <dbReference type="OMA" id="AGAYWMR"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13886">
        <property type="entry name" value="CuRO_2_MCO_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="120"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="213"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="541"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="655" mass="74622" checksum="5F24E67EF56FFEAB" modified="2008-01-15" version="1">MDVTLQQTLQHAWDESWSALRVYTALKQQSDPMALDASFNPNEAPRERVYDWTVDRRIQAPDGVPRLMYTINGKFPGPTIQATVGDTVVVHVRNHIWDDYQVPEPPITSKLDHVHPEGTDRKFAIHWHGLSMRGTQVMDGAAAFTSCPLKPGNETTYRFVVHPEDVGTHWYHSHVGTSRADGLWGMLIVHAREDERKVLKERAPAHETHWDEEVAIAVGDHFHEMSPQSLGKYVSIILSSAEPVPDSGLINGKHIFSCNMSRITDVPCPAGDKDEVGEYAQFHLRHDQQYRLRLVNVGSLADVMFSVDEHTMTVIEADGVLVEPMKVHRIPISPGQRYSVILHREPSSKRHERVWMRAELEGECFKYMNPVLDPFLKAIVTYDVNMPPLSGGWLSPLRARQLFGQQATEKHRRYTSASKRPTTQAWSPDIKDEGIPSEPCHDLEPGTLVPLIPDPAPEFIPERGDRREFINIEVLTRQKLRVPMAYMNLTSWRPYGARGPSQQPLLHRISHTNYSTVEDWEQHGLVNREHELVVSPHPTNPVVYELVLINLDDGPHPFHLHGHKFWVLHTGEMEIPAYRYKPEVQREFDLQRAMKRDTVVVPMLGHAIIRWVADNPGVWAFHCHMLVHLASGMAMAIVEQPTVLQTQPLVPQSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7M7</accession>
    <name>A8Q7M7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729542.1">
        <property type="nucleotide sequence ID" value="XM_001729490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7M7"/>
    <dbReference type="FunCoup" id="A8Q7M7">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7M7"/>
    <dbReference type="GeneID" id="5853848"/>
    <dbReference type="KEGG" id="mgl:MGL_3086"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3086"/>
    <dbReference type="InParanoid" id="A8Q7M7"/>
    <dbReference type="OMA" id="MGWLEGI"/>
    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="196"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="892" mass="102390" checksum="433E91168F280807" modified="2008-01-15" version="1">MRSGTNPFRRAQVPPNTSISTPVTAPHIQPIELDLTPLRAHYLKKTLVSLQLEEELKAIHRPDVLELLGPPFRSSKRIQNDELPLFRHILHQFVLTFPFFQSASPDFFSNKVQLFVERMLERNLIVLDEFDNSHHSSSMVQKTKAYLTMLLSSGLHAQGVEEDIVRICENDRQRLSSLDARRHAAQDPGHAFTTKVNIVCVRRTLSRGRIRHKTLDDFIIATHLNNDEIYVARRYKDFRQLHQQLRALFPTEDLPDLPPKDMSSTEVQGSLQPDSNEEWTDLTAVTPNSLVRETNRLTLRAFLRSILAVPSVADSEIFQEFLTGDPTFLTSEDKADVEIRRRADAVRESQHREFADKMAERVRDLQLHLDSFKSMLKQPDGLSHVFSTIRECAHVDELPPEYKVLVDWATVSMASGLFSMFVGRDSSSRAFAHLKYMHSMMPYFVIRNILRISNPVAMLRSFLDLFLAQPFGQKSLLQRMYTGKLTEELNEIKDLSATVRAKIPDPLYARKVQEFVALPYDMQCLFHEQANAEKNDILTVLLRSPLTAELNTQQMEQVNRANIAYRRLRRQRAHAHSLGVPEPEPNSDDAWLLEDLHVYLNLCSAMHIKEQLIGLIYDHATTDLLKDMVTIFYAPLAQVYRVANISDTLGEIQVFISDLIKTVDDHTALQASNPDAMVSAFVNLVQRHQQTFYHFVHQVHSKGSDLFQRLIRWVELFVNYVRDPREPESCGLGWINLEQCLTDSRVDRARVMAEVDEVIRFVYHRKLQREIKRRRKMARKVVSGAADTPQEEQAFMNTMTEQFGFGTGLQDEIEELDKSELESESTDSSDDDSGPEDADASAIRRERVAHARTTPSTPDFYSSEPSTPTIRAMLPTLQRVLRDKINSRTNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7P9</accession>
    <name>A8Q7P9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729548.1">
        <property type="nucleotide sequence ID" value="XM_001729496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7P9"/>
    <dbReference type="FunCoup" id="A8Q7P9">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7P9"/>
    <dbReference type="GeneID" id="5853854"/>
    <dbReference type="KEGG" id="mgl:MGL_3092"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3092"/>
    <dbReference type="InParanoid" id="A8Q7P9"/>
    <dbReference type="OMA" id="CRYWKIR"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="389"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="450"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="66244" checksum="D7E5D5D3FDCE279D" modified="2008-01-15" version="1">MSDPFFQKKRKRSNDAGSKHPTQTRRKDADEYEDAGDIGAVEDMNLQHTYDDGDDGAAAADRETPAEAKVRLAKLYLEGLHEKEDIDGIDAAAVDRENIAARLRKDVEEGSGHMHIAVATRICAPKPEDILCVRGHRASMTCARTGASAKHLFTSDKDGRIWQWRLRDGTQVCMMPRGYARESEYVGSAPMSNTSGAARRRERARRSTQSPMPSTSSAPYKGHVTLQPGEGHTSAILSLSVSDDGRFCASAGCDKRIGIWETTTTSASSPNVPTRWVKALLGHKDAVCSVAFRGGSTELFSASYDRTVKLFDAAQLSYIETLFGHQESIQDLACLRAERAVTAGGRERTCRLWKIREESQLVFRGGTRSKVHALLEGGDLVDTPGAKKNEVHEGSVDCVSMIDDNHFVSGSDSGTLSLWSLAKKKPLFVVYAAHGYDRAHGNTQPLPRYITSVACLPYGDVFASGSWDGVIRLWALDSSLRSFRFLFDVPAPGVVNSLQLLTPSIEHMDDYPVVPSLWRRRGGAQARLDPVAKTNGHHSSEPHKSSSSLSLRSGLHMSADGHVLGHKESIPPLLIAALAPEPRADRWIRIPNAVSAALVIPMWLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7R0</accession>
    <name>A8Q7R0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729551.1">
        <property type="nucleotide sequence ID" value="XM_001729499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7R0"/>
    <dbReference type="FunCoup" id="A8Q7R0">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7R0"/>
    <dbReference type="GeneID" id="5853857"/>
    <dbReference type="KEGG" id="mgl:MGL_3095"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3095"/>
    <dbReference type="InParanoid" id="A8Q7R0"/>
    <dbReference type="OMA" id="ACHVQEK"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000053">
        <property type="entry name" value="Ribose-5-phosphate isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="251" mass="27115" checksum="43F98AAE6C48C463" modified="2008-01-15" version="1">MASSSQSVSTVESAKRAAAYAAVDAYVKPHHQLIGIGSGSTVPYVVERIYERGEKVNNSCRFVPTSFQAKNLIIERNLNLGDMDTGLQLDVTIDGADEVDASLNLIKGGGACHLREKVLAEAAKEFVVVADFRKMSMVLGENWRKGVPVEVAPFAAKHVLKSLERLGSTDAKLRMAVAKAGPVVTDNGNLCIDAVFPESIMRNPDHLLKQIKLLTGVVEVGIFTNICKAAYFGNEDGSITRQLPDGSRVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7R4</accession>
    <name>A8Q7R4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729552.1">
        <property type="nucleotide sequence ID" value="XM_001729500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7R4"/>
    <dbReference type="FunCoup" id="A8Q7R4">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7R4"/>
    <dbReference type="GeneID" id="5853858"/>
    <dbReference type="KEGG" id="mgl:MGL_3096"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3096"/>
    <dbReference type="InParanoid" id="A8Q7R4"/>
    <dbReference type="OMA" id="SIWDYSK"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="59"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="48451" checksum="71DDAFC265EACECE" modified="2008-01-15" version="1">MADEWRHESEEADEELQIEPRDVELDVTEGTDEVPMDEGDEELDNQDDEMFQDDSIAAFYSHRKSVFCVQLHPNFPNPPIAVSGGEDDAAWIWNTIDGSEIAHLSGHTDSVVAVAFSHDGEMVATGGLDGRIRVWRRHGKDDEWSTWEFLTNLEGPTEVVWLTWHPRGPVLVAGASDTTIWMWKLPSGAEMNVFNGHTGSVTCGRFTPDGRRLVTGSDDGSLIVWDPSTAAPLGKLKDTDTRFALDGGIMSLCVSPDNKLVVVGGAAGGIRVVSIANLDQGGAAQLVGSFDAHDSGESVESLEFIDLIPSSAPSSQGPPAPSNVVARSSTHFVSAGTDGRAIVWDLKAGTKRGEARHEAAVTKMVVHPFTPLFSTSSMDHRLRTWDARTMQTLGTKHGFTDGVLDIAVGPDDGITQGAETGGIGAYVNSAQSKGYKLIGAGDEGVALVFRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7T4</accession>
    <name>A8Q7T4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MGL_3114</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Cytoplasmic vesicle</location>
            <location evidence="1 14">COPII-coated vesicle membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
            <topology evidence="2 14">Peripheral membrane protein</topology>
            <orientation evidence="2 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729570.1">
        <property type="nucleotide sequence ID" value="XM_001729518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7T4"/>
    <dbReference type="FunCoup" id="A8Q7T4">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7T4"/>
    <dbReference type="GeneID" id="5853876"/>
    <dbReference type="KEGG" id="mgl:MGL_3114"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3114"/>
    <dbReference type="InParanoid" id="A8Q7T4"/>
    <dbReference type="OMA" id="MPWNIIP"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="17">
        <location>
            <begin position="2"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="18">
        <location>
            <begin position="68"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="20">
        <location>
            <begin position="348"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="19">
        <location>
            <begin position="463"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="16">
        <location>
            <begin position="577"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP42356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="712" mass="79425" checksum="3B69D3D8091AA853" modified="2008-01-15" version="1">MCKPPCRAVLNPYCQVDVRGKLWICPFCLSRNPFPPHYKDISTTNLPAELLPKYTTIEYTLNRKSQIPPIFMYVVDTCMEADDLKSLCESLVVSLSLLPPNALVGLVTFGTVVQVHELGYEGCPKSFVFRGSKDYSPKNIQDMLGLTPGSRPTPNTGGPSTQPRQPTTGQIGATRFMLPVSQCEYQLTSILEQLQRDPWPVANDKRPQRCTGAALSVAVGLLESTFQNTGARVMLFCGGPCTEGPGQVVSTELRERIRSHHDIEKDNVKFFKRAVRFYENLGRRAAHNGHAIDVFSGCLDQVGLLEMHALCNVTNGYQLLVDSFQMGIFKQSFNKIFEKDENGDLLMGFNATLEVQCTKELKVSGLIGHAVSSNKKSSCVGETEIGIGQTSAWKMCSITPRSSAGLYFEIATPAGQPLQPGARGLIQFVTHYQHSSGQFRLRVTTIARNFADGDSGHVGLSFDQEAAAVLMARIAVFKAEIDDSPDVLRWLDRMLIRLCQKFAEYRKDDPTSFRLSEHFNIYPQFMFHLRRSQFLQVFNNSPDETAYYRHVLNCEDVNNSLIMIQPTLMSYGFDGPPQPVLLDSMSIRPDVVLLLDTFFHLLIFHGETIAQWRKAGYQDQEGYENFREILEAPQADAQELLMERLPIPRYIVCDQNGSQARFLLSKLNPSTTHMTGGAYGTSGQGAAIYTDDVSLQVFMEHLKRLAVGANSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7V2</accession>
    <name>A8Q7V2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3132</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729588.1">
        <property type="nucleotide sequence ID" value="XM_001729536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7V2"/>
    <dbReference type="FunCoup" id="A8Q7V2">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7V2"/>
    <dbReference type="GeneID" id="5853894"/>
    <dbReference type="KEGG" id="mgl:MGL_3132"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3132"/>
    <dbReference type="InParanoid" id="A8Q7V2"/>
    <dbReference type="OMA" id="NMPQTAV"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="39"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="423" mass="46727" checksum="2E8C5E2F3C5A11E5" modified="2008-01-15" version="1">MLSFATLVSARAMARAAPRYTAAFAVASSRHFTMSTRRLGVVKVPEMAESISEGTLREWHKKVGDYVNESDEVATIETDKIDVAVNSPESGVITELYAEAEDNVEVGKDLFKIEPGEAPKEQPKDEGKSEEPKKDEEKSEEPKKEEPKSEEPKKEEPKKEEPKKEPKKEEPKKKDAGRQESEVAPKAGARTESRVKMTRMRKRIAERLKESQNTAASLTTFNEIDLSALMSFRARNKDRLLKETGIKLGFMGAFSKACALALRDIPSANASIEGEGLGDTIVYRDYVDLGVAVSTERGLVTPVVRNVENMGILEIENAITELGLKARDSKLSLEEMTGATFTISNGGVFGSLFGTPILNLPGSAILGMHAIKEKPWVVNGKVEVRPIMVVALTYDHRLLDGREAVTFLVKLKQYLEDMPTMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7W0</accession>
    <name>A8Q7W0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RIC1 C-terminal alpha solenoid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729595.1">
        <property type="nucleotide sequence ID" value="XM_001729543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7W0"/>
    <dbReference type="FunCoup" id="A8Q7W0">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7W0"/>
    <dbReference type="GeneID" id="5853901"/>
    <dbReference type="KEGG" id="mgl:MGL_3139"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3139"/>
    <dbReference type="InParanoid" id="A8Q7W0"/>
    <dbReference type="OMA" id="MVYDRAM"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="672"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="905"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="905"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="938"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="996" mass="108195" checksum="1EE699F9BA18FBAB" modified="2008-01-15" version="1">MRSLILSAPELAPSSQALLATFQPATGDAYHTCTNEPLSARINFQLLFLDALQVDPGIACIACVDAHLFVSTKSPAAVQLVSWPSSTSSASTSAASASVSASSAASAPPILLAHLPWLQVPLSSSSSLALTPSPIVHAEHSYATDLSAWISADGSAYIVGRNDTWVGACAYRAVDSAHKNVPTTTALNARFSLLALGFENGHITLFEFQTATQTPQFVHSLTLPHITGRVICLDWTADGHALAVGYEHGWAIWSTFGHVMCHSFREDWTTATRSYRDNFQFGVQSVFWGLGGTELFVLARPLSPDAHAQDDERTLAYVVPFVKAAATTHMTPADVNAGFLLGDASAYMYRGHEQSDAGLLSPGNDVWRHIPFPAEYLTTQWPIRCTALSPDGRFLAIAGRRGLAHYSTASGHWKLYEVATQALSFCVRGGMAWYQHVLIAACDCMGEIQIRLYSRDQPLDNAHLLDLVVLGAPVVTLALFETSLLLYLADNTLVHYLITPTREHIRLRLCGSISFDGIIGEPSRVRALSWLVPPVQRDIGHPADDLTVANLLFLIDGMLVLLRPARASDDEQLSYDLQVLHEHIESFCTPIYTPGALSHSLWAFDGHHMSVWLHPMSRSDAPDCVLPVSSTYPLCILSDRGILLGAESLPVLRRTLDTTSYRLRLHTTLFLDHVLRAILERRHLLDAIEIASLYVPLEYFSHALEVLVHAVLEDEADAAPQQGNHPGDLTSPGNGITDSVAAGTASSAATYAGTRAPILPTVLAFLDHFDEALQVVVRAARKTEMSRWRYLFDAAGRPSTLMQHCLDRHDYASASAYLLIVHELEDGATSLQATAKALARFEEAGEFALLRDTLSFLHGLDENGDILRTCTSAASELVLSSGISILSREYDVEVERRMQGAQTVPLLRTSLSPSLSRQAPSPRKLGLTDSPRRPTSVARKSSMSNSPALRTSSAHVLHRAARSASITLSPSMPRMQANGRLVLPPTSSPGLSPRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7W2</accession>
    <name>A8Q7W2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cation-transporting ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3141</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729597.1">
        <property type="nucleotide sequence ID" value="XM_001729545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7W2"/>
    <dbReference type="FunCoup" id="A8Q7W2">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7W2"/>
    <dbReference type="GeneID" id="5853903"/>
    <dbReference type="KEGG" id="mgl:MGL_3141"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3141"/>
    <dbReference type="InParanoid" id="A8Q7W2"/>
    <dbReference type="OMA" id="WYYSLFN"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="982"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1019"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1067"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1097"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1136"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="13">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="12">
        <location>
            <begin position="234"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1188" mass="131997" checksum="2E03EA88EB9ACAF4" modified="2008-01-15" version="1">MRYEQWVKSEEWTFVITASLLLVHALSYLATHWSVRAKALFTSTSVSAIDMADYVRVLPHAHKGEGEMLPLRCVKRDRSLNKDEHERDEYSFVYQADKYVLAFPDSTAPSTTITASPDVRERTFRRVLYPADAHMQLQHVQTSQGLRGEALARAQRIYGGNVLDIPVPRFLDLFIEHAVAPFFVFQVFCVGLWLLDEYWYSSLFSLFGLVAFECTVVFQRLRTLNEFRTMSIQPYDLHVFREGKWTVLSSSELLPGDLVSVTRTKAESALPCDLVMASGSAIVNEAMLSGESTPLLKEGIALRNGTDTLDDQGADRLHCLFGGTKALQVTPGDSIPGVPRPPDDGALAVVLRTGFGTTQGRLIRLMVFTNENRVSANNWESFVFIAFLLVFAIAASAYVWLNGLKMGQPKGKLMLHCVLIITSVVPPELPMELSMAVNASLVALSKLAIFCTEPFRIPYAGRVDVCCFDKTGTITGEDLEVQGIVGTEAHGTSDALNDELVDLKHASMSSKLVLAAAHALVIVDDEIVGDPMERRALDAMGWTVKPGDQIRSLTDPKEPGVTIRTRFHFSSALKRMSTVSHVQSHPNQLLAATKGAPEVLKPMFTALPSNYDQVYRHYTRHGSRVIALGYRWLDANEARSIKREQVECGLQFAGFLVLHCPLKPDAIESLKQLNESSHRCVMITGDNALTAVHVAEEVEIVLREPIVLDKREGSQDDNDLVWRTTDDAIVREQNIGEELHRHLFDEYDVCMTGVALRQFEAQPAKLRELVANTVVYARVSPNQKELILSTLRSLGYITLMAGDGTNDVGALKTANIGVALLDGTEDDLQKIAEHQRLERMKKMYESQLNMMARWNHPPPPVPPALKTAFPQLEEAREKAARKMRSQRASNPMAQFDLSAITSSMEQLDDQEGPPQIRLGDASVAAPFTSKLANVKAVCSIIRQGRCTLVATIQMYKILALNCLIQAYALSVQHLVGIKSSDYQLTVSALLISVCFYCISRGKPIERLAPERPVSTIINVYVFGSILSQTALHVAAMMYIQNLSASFEQLGEVDLDAKYTPTLLNSGVYLLSMSQIVSTFAVNYIGRPWRESIPENKALYYGLLGASAIAYLGALELLPELNEWLQLAKMSTEYQSWLVTVMVLDFVGSYALEAFWGLFADVQPKPLILQGQKLRANRQKASLTEKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q867</accession>
    <name>A8Q867_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729669.1">
        <property type="nucleotide sequence ID" value="XM_001729617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q867"/>
    <dbReference type="GeneID" id="5853975"/>
    <dbReference type="KEGG" id="mgl:MGL_3213"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3213"/>
    <dbReference type="InParanoid" id="A8Q867"/>
    <dbReference type="OMA" id="TFWACLT"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="62"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="398"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="715"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="953" mass="101557" checksum="E4B5754B03115B63" modified="2008-01-15" version="1">MSQLQTILQRAVALERGIGAAKRLTRLRASHVISPTTVSSALVSSFCSAYETDSMPSVRGSMLVKNVWMTYPTRPQVPVLCRVDMTFPAGEHTYVIGASGSGKSTVAALLARLYDPLAGSVSLDDFDVRTWPLGMFREHVLCVRQEPLILERSMRENLDPKSCMPQAMLDAVCSAMRLNDLVNTLPAGLDTVLGTRGIELSGGQKQRIALARALLINPTVLVLDEVTSALDRAAAVAVHTVIRAWRQGLTTVFITHDLSLIGAGDRVYVMADGRVKEQGTLGTLRCAMADATAAVQHYDASPPAYPGLETDPVSPVTSTDPVGAGQGTMDDVSHQVTETATATTTVMSLTRRASQILNFDAQMAALCTGATSVGQPPSIACALLWLWRTIPSRTALCAGVLVCVMSGATVPAFSLCLTQILMAIAHTSPVSISAMIGATACVAVADGVLKGARHAGMDMLAIAWVERLRVHVAHALLAQDCAFYDDACHAPSTLTNTVVKEADDARLFVSELLGQGAVVMAMGLGTLVWAMVRGWQLTLCACALLLVGLGVLSVHGAWLARCEQMAMHARTCSAERVFDYASNQRAARAMALDTPMYQDAIAAGNRAYVAGMRTARAVACGAGIADALMYSAEAVLYAVGAVLLVHRTYDLQRVLDVLSPLVFTMSYAASAAAVMPAAGQCMPALGQIHKLSDLRTDTASDKQGHRDVPDLSGRLEFEHVSFAYGMHGNAPLHDVSFTIEPGEKVALVGRSGCGKSTVLALAQRLYEPAHGHVVLNEQGVTAADVDSQQLRRHLAVVSQHATLFAGTIKENVLAGSADITDAELVRAACAACVHEFIAGLPEQYATRLGTIATFSGGQMQRIEWARAFARKRAKIWLLDEPTSALDQATRDHVLSNLSQLTGTTAMIVTHDVQVMQRCDRILLLDGGRIVASGPWHALCMQPTLQHVLLESDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8X6</accession>
    <name>A8Q8X6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729328.1">
        <property type="nucleotide sequence ID" value="XM_001729276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8X6"/>
    <dbReference type="FunCoup" id="A8Q8X6">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8X6"/>
    <dbReference type="GeneID" id="5853635"/>
    <dbReference type="KEGG" id="mgl:MGL_3363"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3363"/>
    <dbReference type="InParanoid" id="A8Q8X6"/>
    <dbReference type="OMA" id="CEHAVNP"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="531"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="658"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="786" mass="84261" checksum="AF488B8262248D99" modified="2008-01-15" version="1">MAKSKGTKPPKSRPASTSSLSQPQMADQNVQITAFSPDATLFAQLSQAVDRARLRVYASHKAGVMADFLLPEAQTCRAIAWILLGAQSESDLSPSSSSTSASSKKRKALARAAAEQHTSDSTAPTPHVALGMSDGTVLVYSPVTARVMRVLVVSSQDSSTAALVSLSYRDNHLWGVTANGWVHGWVVSGLASASVHERVPPTRHFLPDSKMPMSLLTCGPSHRMLTAHHALALYDVSTERIAAPLRQFTGHATPITHAAWAGEDAFVSAAAEDRHLYYWFTHLSHAGAMLTLDAPAHRLVTWAEADGTAMLLVISQLGTANVYRLPREVPKAKGLATLTPVSVVSTAFEGTELLDAICTPDGTLRYARIVKGFKVVLDEAPLYEDDNALRSVVTLAASSAPKPEVALRDTQRYKEARGAAGTRAELPGHTAAAAALLGTEGGLLPDAASSSVDLHDDALQDGDVNEPTLAQRLKALKVQRGDARASTVNEREEEDEDDGDVDGAAPDPGAEVPVGGASLASSLTQALHSGDHALLTSCLVHSDVTLIRATVRRISGPLAVRLLEACVDRLNRGGVKSKGALGSGRARGIVEWIHQSLTFHAAYLMSLPNLVARLSQLHHSLAARLASHERLLALKGRMELVMSQIDMHMSYTADEAQMPVQGQKLGKRSSATELEKKQQASQLQQQGQTWVEPDEDDDVEDIGLTAGNDVSMNADEDDYEDGIPEDMDEDELVNEDALEETEENSDLSLEEDEENELGLDEDDMASDDEDEDDGDDDNDNDTDNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q975</accession>
    <name>A8Q975_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729392.1">
        <property type="nucleotide sequence ID" value="XM_001729340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q975"/>
    <dbReference type="STRING" id="425265.A8Q975"/>
    <dbReference type="GeneID" id="5853699"/>
    <dbReference type="KEGG" id="mgl:MGL_3427"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3427"/>
    <dbReference type="InParanoid" id="A8Q975"/>
    <dbReference type="OMA" id="NEINCVF"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="512" mass="56501" checksum="8A74AF52F1E766D9" modified="2008-01-15" version="1">MEYAPIELFAVVMSGKMGFNEINCVFRQIVDGVDYLHGLGLAHRDLKIDNCVMTSDGIVKIIDFGTATVFQVPGKSALSATGIVGSDPYLAPEVLTRQTYDARMTDIWSLAIVYMCMVLKRFPWKIPDPDADPSFKLFLLAHPELGGIEPASLLDDEDEIVDADHETSHITGEMSPKSRYGPVLETSGAEKLLRQFSDETGTAQIRTAYEAGYDISAASTSNSSSVTPVATREGTISREMPQPSHSSQSLNPYRQHTSDEGYEIPSLSSSVVYESESPSMSVAHSPPDNGAFKEKGPTDFNEDPQPRAADSIFRILPLRSRSCLSRMLMLDPSKRATIGDLLRGRRYGAPDSAISATVYAQQQQQQQVAESAEQMSPDARPVDASGIKGISEQPHRLLPYGTMEPYVDEFEDDEDFGDDWLKSINTCSHWISHTNELQSSSSAFTLAPSTSSTPVPRQGSPLLTDENCFADMGFRSTDDIFDKPPIRPPPNHMHVSQHSVQEPKRRLFPRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9B8</accession>
    <name>A8Q9B8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729417.1">
        <property type="nucleotide sequence ID" value="XM_001729365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9B8"/>
    <dbReference type="FunCoup" id="A8Q9B8">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9B8"/>
    <dbReference type="GeneID" id="5853724"/>
    <dbReference type="KEGG" id="mgl:MGL_3452"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3452"/>
    <dbReference type="InParanoid" id="A8Q9B8"/>
    <dbReference type="OMA" id="YDRFNIH"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9938" checksum="200ABB7EF23CCFB9" modified="2008-01-15" version="1">MSELRYWGNPQLEHLHARYTGTIHPDTTKHEWATHQHRDTAAAIVANGALLTYNSIADGESRARTKFRVCERMIQPCGPPPKQQEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9C8</accession>
    <name>A8Q9C8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA capping enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729423.1">
        <property type="nucleotide sequence ID" value="XM_001729371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9C8"/>
    <dbReference type="STRING" id="425265.A8Q9C8"/>
    <dbReference type="GeneID" id="5853730"/>
    <dbReference type="KEGG" id="mgl:MGL_3458"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3458"/>
    <dbReference type="InParanoid" id="A8Q9C8"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="1">
        <location>
            <begin position="38"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="197" mass="22686" checksum="2271FE76708798FB" modified="2008-01-15" version="1">MQQSPRCTDGLIFTCLSSRYSFGTNVKILKWKPSQSLTVDFLIRVRPEVYEGIGSKRRAEAANEKPVFELYARTNDDSHVYFDDMRLNDDEWARWMQFGNALDGRIVECAPFLVSSGTGISHTSWRPVRLRDDKIVANHQSVVTSTLESIHHGVSEEKLSDSAPSVAENWFNPNRWARRVQFEKNQSRVFSDLHLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9J6</accession>
    <name>A8Q9J6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729458.1">
        <property type="nucleotide sequence ID" value="XM_001729406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9J6"/>
    <dbReference type="FunCoup" id="A8Q9J6">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9J6"/>
    <dbReference type="GeneID" id="5853765"/>
    <dbReference type="KEGG" id="mgl:MGL_3493"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3493"/>
    <dbReference type="InParanoid" id="A8Q9J6"/>
    <dbReference type="OMA" id="GMMLSEW"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="57278" checksum="23031D1C32D9646B" modified="2008-01-15" version="1">MPSRDAEPDDAGSVRSGNLSGIIAGDFLVASQHPASIQREDAPLLADSSSTSMIQPHISSMGNASGYGAIRPSSSLAQSISPDSHLRSELYTLLNFTIPVCATHLLELSLSVVSILSLGHLGTVELAAVSLAGITANVTGFSVISGLISALDTLLPASYTRQPHLMGLWTQRVGIIIMFILPAIVLLWLNAESGLLLLGQEPDIAHKARQFLAVLALGLPGHAVFELCRRFLQAQGVMHAPTVVLLIVSPINALANFILVWGPEQFRFGFLGAPMASAISMWLMAILCVMQCALLSHGTWGGFSRKAWDPAALKTCASLGFAGLLSLASEWWAWEIVGLVTAALGTRALASQSVLLVLSSVTYQLPYGAAVASSVRVGNLLGAMHAQSARIASHAAIVLSLLIGLLNSSIVFFTRHHLGYLFSSDDAVVELVASVLPIMALFQCADCTCGIVGGILRGCGRQSLSAFINVTAYYMAGLPVSLFLAFGPWHLGLAGLWWGLTIALVYGTITSLWYVYYMDWDKVMQQVHRTMHASVQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9P9</accession>
    <name>A8Q9P9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3532</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729497.1">
        <property type="nucleotide sequence ID" value="XM_001729445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9P9"/>
    <dbReference type="STRING" id="425265.A8Q9P9"/>
    <dbReference type="GeneID" id="5853804"/>
    <dbReference type="KEGG" id="mgl:MGL_3532"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3532"/>
    <dbReference type="InParanoid" id="A8Q9P9"/>
    <dbReference type="OMA" id="PWRENDA"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="11">
        <location>
            <begin position="242"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="184"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="500"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="624"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="683"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1032" mass="112852" checksum="69CB250A867B22BC" modified="2008-01-15" version="1">MSSLHVGVTNAVFEALESLIQMAQPLSTRNMQTIIKTCVPLALQRLADVPIAQAWLLHLSRIVFKDVLGSARMREGDAPHSMWEHTIRDAGLGATSPHVREHTLQLLVSLQDCPLPLQTLLPFLVDGVQDPDANVRAAAKTAISSLYAPADPTLRSELKLTLMERHVHASTFDEIMQSVVGHTSTAADAADAPATPTPRRTMTTATTESSTSSSPSLTLSSKMPELPAELVSVPSDDIRPVHILSHYDMEHAFSSAAQALDGKETETNWQPREKAIITMRGMLKGTVPDELSHAFLMHIRSLQEGILKALASLRTTLAMHAIGLIRQLALTFGAHLEHTLDAFLTSLMRMAGFTKKIVATASQLAVSTILACASVRHSYWQLLSAGLQDKSAATRVYMCKHLGVILHVHGQRRADLEAHHGLEMMMQCLGRALGDPSAEVRSAARDVFFPFHNMYRAEAEQVLMSCAPATRKQVAASLEHVPSLRRTPTRAGPTRAIVAAKRAAMHQQQQQQQQQQQQQQQQQQQQEEEEQEEKDQQQPQQMQLQPPDALHQQTHDAAMAERMRMPRESLWHPSLVDGPDASTDLLHSDVPWSRNTADDSVARDRAQDDEGDITAMLHGLGIQSENHTPKQMGIHSNTDTFKTATPSSPSSSSSNTPRKASFLASTPTMSSHVPETPTPAKVPACTASPSATPTLSTRTMPSLVSSLTQPPTATLWFLTRCASALQMWSNESVEALSWDEMLAQFVAGRASTAVLCRIAHDLDASASISSEDVAKMLAVLSTTYVTETTNEVRWILGLCILHRLARAACAEEVHEGTWLALVLQVPATVVHDHATLAMGAGRSMVETWSELTQSRKPCARILETECASERHDEGEKGKDLRSNMERGVGGSQNQAKLALTLYAIERALARVAPPVLEEELHVTVPLVHSTLRDPHAPVRRACVCMLVHAYARLADKDQFRRIYAPLSAGEERLILVRWTAQSSCEAIAQWSDNGKHKPAGTNIRAALCGTRAAYVDAAADMSERGLTRGLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9R4</accession>
    <name>A8Q9R4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Origin recognition complex subunit 5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729508.1">
        <property type="nucleotide sequence ID" value="XM_001729456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9R4"/>
    <dbReference type="STRING" id="425265.A8Q9R4"/>
    <dbReference type="GeneID" id="5853815"/>
    <dbReference type="KEGG" id="mgl:MGL_3543"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3543"/>
    <dbReference type="InParanoid" id="A8Q9R4"/>
    <dbReference type="OMA" id="XANILVA"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="1">
        <location>
            <begin position="174"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="356" mass="40320" checksum="A953E1E0EEAAB731" modified="2008-01-15" version="1">MWPLLAEMMGCQGKVMVVFVSPLSWASFRSTSGRTMSTSPLCIRIPRLPRDDVLALLDQDAETALTHVPDGIDFGLYRVVCQVFYDTVKDTIRDEYEIRILYTHLWRKLMSVVHAKGVRPNMPSLMPHISELCRDALARVAPRHVGPSAWALDSNVTKPESALMALPSRTGFGVMQAFLLISAFLASYNPAITDVKYFVRELKVSRKRRRGKAQKAAQEALMEMEGMTEIFDRTQFWGPRPFTLERVLAMYHALLADFELDLNEDGLLAPAERAARTSDNKAELNLEHVAGEFWSRSSTALAELNELVRQQLIVRISPANKLGAMQYRVNASFEYVYQVAVAVGFPLRVWLWDTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9Y9</accession>
    <name>A8Q9Y9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729102.1">
        <property type="nucleotide sequence ID" value="XM_001729050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9Y9"/>
    <dbReference type="FunCoup" id="A8Q9Y9">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9Y9"/>
    <dbReference type="GeneID" id="5853409"/>
    <dbReference type="KEGG" id="mgl:MGL_3569"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3569"/>
    <dbReference type="InParanoid" id="A8Q9Y9"/>
    <dbReference type="OMA" id="HEWYENQ"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="76"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="554" mass="60410" checksum="5BDE1722E44206DB" modified="2008-01-15" version="1">MIDSLSWQDLAQAKRDALKNSIPKNWRLEQVPSPEHLQNGVEFVESNLSPEERQITELPLEVLRPALQAGLVSSKEATLAFAHRAALAHQLTNCLTEFILEDALRRADELDIYLKETGRPVGPLHGVPVSLKDLFYLEGTDTTVGFAAWLNDKAMIQDEAGVVKILRNAGAVFFVKTNVPTSMMCAETVNNIFGFTNNAINRFCSAAGSSGGEGSLLALRGSPLGIGSDIGGSIRLPASVAGVWGLKVTPGRFPIIGTRSTDPGQVLIPSVVGPMANSLQALEICTKLLLSSQPWLVDPSVVELPWKNCDLPSNLVFGVMLNDGIVHPQPPIEQALTQVVDALERDGHEVISFSPPSHFQALTLWLEIMTQCAGEQIHELIEKAGEPLIEEVAAIFGSKKGERSAISVAEAHEQAMGLKAYRMEYERAWNETAQQSRCGRAMDGILLPNTGVVCWRRGGVTYQGYTPPANVLHFPSISMPLAKAEPVPQTHRQNFLSSIDEDVYHAYDPDMSRGMPVGIQLMGRRFQEEKLLAMAQAVEFSCSRASLTRTKACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA12</accession>
    <name>A8QA12_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729111.1">
        <property type="nucleotide sequence ID" value="XM_001729059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA12"/>
    <dbReference type="FunCoup" id="A8QA12">
        <property type="interactions" value="689"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA12"/>
    <dbReference type="GeneID" id="5853417"/>
    <dbReference type="KEGG" id="mgl:MGL_3578"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3578"/>
    <dbReference type="InParanoid" id="A8QA12"/>
    <dbReference type="OMA" id="LVRFPQK"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000015">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="10">
        <location>
            <begin position="754"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="947" mass="105812" checksum="5FC42EDC06CDA60C" modified="2008-01-15" version="1">MYPTEESRPSGSCLDSEKVDTGFISFFRNLPATVPGTVRLFNRQDFYAAYGDDALYVADTVFKTKSVLRYLGGKSREDIGLPSCSLSLTAAKSFLRDALTTKQLRVEIWASTSGDGSGKRGSTWAIAKQASPGNLQELEDLLFLQSDVVSSPIVLALRIKVEDGLNQVGAAFADATNREFGIAEYAETDLFSNSESLIIQLGVKECVLPTDEAGSDYNLQKLRSMIERCGCVITEVRRGLFVNKSVEEDILRLLPSSQQATLTSNLNKKLAMTSASALISYLNLLGDESNFGKFTLCSHDLSEYLRMDNAALRALNLFPDPHGQASGTNKGASLFGLLNHCKTAQGIRMLNQWLKQPLVNLHAIQNRQSMLSILLDDPEARHRLQDDFLKYMPDMLRIGKRFQRGVATLEDVVRCYQAVIKIPDLTQVLRSIAIVSEADCALFHSTFVAPLDELYQHLVKLVEMVEMTLDLDELQYHNYVIKPEFDETLRLIRTKLDVIRDQLDEQHIQVGHDLRLDTEKKLHLENHSSYGYCFRVTRTDAGVVKNRNGYLDLSTVKGGLYFTTPSVRELNDEFRSLSEDYASTQSRLVKDVIDIASSYTPPLEHLNVVVAHLDVIVSLAHVSSNAPIPYTRPELRERGSSLVLRDSRHPCLEVQDDIHFIPNDVSMVPNESEFLVVTGPNMGGKSTYLRQIGVITLMAQIGCFVPAAAGAQIPICDCILARVGAGDSQLRGISTFMAEMLETATILKSATRDSLVLIDELGRGTSTYDGFGLAWAISEYMVTQIHCKCVFATHFHEMTSLARKLPGVENLHVVAHVTPRENGSQFDKDITLLYKVEPGSSDQSYGIQIAELADFPEDVIRLAKRKAEELEGIEDKRDITRMDSDVTHNGVALVQEFLHAYEDRVQITKRQRKDDKHAQLEALESCMRDFDERIRNNAWTSNILNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA13</accession>
    <name>A8QA13_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3579</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729112.1">
        <property type="nucleotide sequence ID" value="XM_001729060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA13"/>
    <dbReference type="FunCoup" id="A8QA13">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA13"/>
    <dbReference type="GeneID" id="5853418"/>
    <dbReference type="KEGG" id="mgl:MGL_3579"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3579"/>
    <dbReference type="InParanoid" id="A8QA13"/>
    <dbReference type="OMA" id="ENDDCPR"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15585">
        <property type="entry name" value="PHD_ING3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042020">
        <property type="entry name" value="ING3_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="198"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP41898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="265" mass="29915" checksum="416C11E225047A62" modified="2008-01-15" version="1">MKELDQTSEDAKVELNATWKQFFDTHHRSLEDHSCLTSELSAATCKSHLLKIRDKSQLICSLAEEKLALALSAYDTVDRQIRRLDIDLLKNERSLYAGLRKELESSNSMESSTSSTPVPKDSDRFSPSGQLLTFWSALISLDPLVCLEYLKEHMQSNRGMPHNVQGHERPRDAKPSSPKTSSDSSVPIEHIDADPSEPKYCYCQRVSYGEMVACDNDDCPCEWFHIGCIGLNHPPKGKWFCQFCAPSNWKGTGVRVPLDAPRRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA79</accession>
    <name>A8QA79_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729171.1">
        <property type="nucleotide sequence ID" value="XM_001729119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA79"/>
    <dbReference type="FunCoup" id="A8QA79">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA79"/>
    <dbReference type="GeneID" id="5853477"/>
    <dbReference type="KEGG" id="mgl:MGL_3638"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3638"/>
    <dbReference type="InParanoid" id="A8QA79"/>
    <dbReference type="OMA" id="RTDYVWK"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="4">
        <location>
            <begin position="643"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="708" mass="81435" checksum="A30EE4A6C4AF312D" modified="2008-01-15" version="1">MSASSEDSFNEEAARIGCDDEESAFRDSSSSRMVRDSSLSRLGYSPTISGSSRARSQTRHRSARSPDARPSSGRSQSVSRASQRLTHSYTSNASHTNGDEGDERVSPYTSLLGFELGMLASFLIPRREQCHQRFEMTIDDLTFLGHPVTQEHVAPQSRTVESTIFNVVMVLDRSNMYPSVRCIDSKHWLQLYYTILFKLTAMLAWEEARVQYVSEQAHLLVQMREDYLQNGSNFHEYLKASLNASSLAQTLRDIQRSMARRHNIDVLINENIGLTLKLPQLLQEPNKAERAFEFQPMYDMHDSVVQRGDLPEPRDLTNPLVRPYASSLSLPSILQEWSRTTGPFLLPWKTLLLPEEAFLPYRQSSIFKMAEPLTHMFCPSPQGCMTFAQAAEALQWDLYKDVYPMVRHLIYYADAQVIDVPRIQSLYAINPTFDTHELAGLSERWTRQFPRMMSLPEFLTIVSSSLRPFVSHCVVAPREYAPIDILIWLLRQNVLTQLHVYLRLLITARDQLRAVDLRRERRERQLARKHRAAHSVDAPPSSDQEMLIDRLRTQMEHGLNIPQRPAKDRSHANSSHATSRASSTSSIDDWPSGHMHYSGGSDYFHPTSGNELDMDLEEDRFDDLLPGGRPHPIIIQEPARANRTESEWISALFDGKHPWHTRWLIRLFPYLNGKHNVDEIIAREKIRRRDLKSIISEFDANLLHFYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAC2</accession>
    <name>A8QAC2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729214.1">
        <property type="nucleotide sequence ID" value="XM_001729162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAC2"/>
    <dbReference type="STRING" id="425265.A8QAC2"/>
    <dbReference type="GeneID" id="5853520"/>
    <dbReference type="KEGG" id="mgl:MGL_3681"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3681"/>
    <dbReference type="InParanoid" id="A8QAC2"/>
    <dbReference type="OMA" id="AVYIQHQ"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="378" mass="41059" checksum="39A7D772867DB807" modified="2008-01-15" version="1">MWERLPGGPASIIVFLCILAAYTVQTESIQYIQHTLGYQKPLFLLFVTHSSFVFLLPIYLGFIHVFTTRSTTQCCSLLRRDIRRQLDFAFGPQDTPRRRASTDVLRLLAILLVLTVALTVPSVSWFLAVPLTSMANITSIYNTFSLWALVFSVYFLQEPWSYLQAVAVLLGVLGVAISAYGGTTQPAIVAGLTGGKVITYALLGDALALVGAISMAAYEIFYKRLTVIPHDESLGSFAPLPSSADDDVTHSQQETEPEGELPFGLHPIAMTTGIGAITFALLWIPLVIMHATGGESLEAPKHVGTFLWIALSVVCGVLFNGCFAILLSLWGPVLASMSCLLTTVIVQLTDVALGIPFSWIGMLGNLIITVSFVCLLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAC6</accession>
    <name>A8QAC6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729218.1">
        <property type="nucleotide sequence ID" value="XM_001729166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAC6"/>
    <dbReference type="FunCoup" id="A8QAC6">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAC6"/>
    <dbReference type="GeneID" id="5853524"/>
    <dbReference type="KEGG" id="mgl:MGL_3685"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3685"/>
    <dbReference type="InParanoid" id="A8QAC6"/>
    <dbReference type="OMA" id="TERMEDH"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="159" mass="18853" checksum="0C71B102115BF425" modified="2008-01-15" version="1">MNDDRETARLWRVNRTIHELVADRGYEVSEEELNVDLDTFKAEVTSNGIVDRNRMNFFTQHKDKPEERLFVFYSTERNVGVKTMRQFINILEEKNITRGIIIWSDKMTSAAKKVIEAMRLQLVLEDFEEAFLLVNITHHQLVPKHEVLTPDEKKELLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAD7</accession>
    <name>A8QAD7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729229.1">
        <property type="nucleotide sequence ID" value="XM_001729177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAD7"/>
    <dbReference type="GeneID" id="5853535"/>
    <dbReference type="KEGG" id="mgl:MGL_3696"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3696"/>
    <dbReference type="InParanoid" id="A8QAD7"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="75" mass="8354" checksum="FF14500B1FE2FA91" modified="2008-01-15" version="1">MVSLQDTSSTYSLDDIHTKQTRKSMDEAEDVMVKRALGHVAFSPLPSLQASSLTDLPDLSHCDDKESIVRYVELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAE2</accession>
    <name>A8QAE2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729234.1">
        <property type="nucleotide sequence ID" value="XM_001729182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAE2"/>
    <dbReference type="GeneID" id="5853540"/>
    <dbReference type="KEGG" id="mgl:MGL_3701"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3701"/>
    <dbReference type="InParanoid" id="A8QAE2"/>
    <dbReference type="OMA" id="NDKAYHG"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="51"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="398"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="493" mass="54086" checksum="29AEB648C6DBA64B" modified="2008-01-15" version="1">MSRWGGAWHLSRETLPVMLCALAGLLFSGLELDTMTSWRAFVKVDKFLILVPIMLNLKGNLEMNLSMRMATEANIGEIDHRRTRQLIVKGNMTLLQVQALIVASAAGIMSFILGNHERDTPLPESFPSQLSFRMRRGPVHSTKPPIDKALQLRDGYFEFALVLAVSQLAASLSSAVQGSFICALVVWARQLGFDPDNMVIPIAGSLGDLTTLTLLGLLSAALLYFEGTGIATIVFLGLIILCVICMFFTLRNVYVRELLAYGWGPLFAAAAISSMAGLVLEKNASHYEGYPLLAPVVAGMPSIAAAVHTSRLSSALHANTFKARTRPVHAPYVPLVEQDERQEGTAAASNECDPPTQLAASSLSPWMVSWWTQLAEQLIESLSPQGDDWIVPLTLVFNVVMIQVVFFTVLFMTGVMQFGLAFFVCLVFSISLLAGFALVFAHTLCLFLWYWDYDPDTTCMPFTTALVDICGQLILLLTYNVAIFLGDRITTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAH0</accession>
    <name>A8QAH0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent DNA helicase II subunit Ku80</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3729</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729262.1">
        <property type="nucleotide sequence ID" value="XM_001729210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAH0"/>
    <dbReference type="STRING" id="425265.A8QAH0"/>
    <dbReference type="GeneID" id="5853568"/>
    <dbReference type="KEGG" id="mgl:MGL_3729"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3729"/>
    <dbReference type="InParanoid" id="A8QAH0"/>
    <dbReference type="OMA" id="YRREYHM"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="10">
        <location>
            <begin position="123"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="405"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="539" mass="59459" checksum="6C7431DC0EF4E5B7" modified="2008-01-15" version="1">MAFWHHMIEDVQGSAMEPLSKACSDALAPTLHMSTSAPTRTVLSFGNVHDFEKASLDIPVHILKATALQRPQAPRRVMKGEDDMHSKRHVESRRLLYRADDLLKVHKAGHAIVPPTAHTEMDNVTPLPEECAAFIQRAYKLGASLVPLENAPPALPTEAGLEILHFVSASTYRREYHMGETYYVIAHPSSKRAQVALSSLVQAAAVKGVYALCRLVTRPNADPKLCILAPLIESEYDAFYLVHVPFRDDVKRVAFPPLDRVMTSTGASIFEHPTIPTNEQQSTMDAFVDQMDLMDMDDEGDPEGWYTPTLSYHPAIHGLKNAIKWRYLYPQAPLLPLHASLQRFLHVPRRVEERARPARDACAAAFGVHVPPSLVPTAKRNAGRTNDADIHTDANSDTISLNLIQSDSKAVPNTAPESGKLTHSDSDTDTDTGSPRAHDIDQDPLNNLREQVTVLSNTPSIRVGDAGHLRLNHLKPDFEALLSTAAVSETCHAMAQALLALVSEKKDLSVLMPALLSFRQHAAELDEALTWNSYVYEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAK7</accession>
    <name>A8QAK7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729299.1">
        <property type="nucleotide sequence ID" value="XM_001729247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAK7"/>
    <dbReference type="FunCoup" id="A8QAK7">
        <property type="interactions" value="863"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAK7"/>
    <dbReference type="GeneID" id="5853605"/>
    <dbReference type="KEGG" id="mgl:MGL_3766"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3766"/>
    <dbReference type="InParanoid" id="A8QAK7"/>
    <dbReference type="OMA" id="KLHVPMV"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728043" description="Bms1-type G domain-containing protein" evidence="12">
        <location>
            <begin position="17"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="Bms1-type G" evidence="13">
        <location>
            <begin position="50"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="376"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="559"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1007"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1061" mass="120990" checksum="9F9611E8A72E9BBB" modified="2008-01-15" version="1">MYFVWTLTVIQAFIAAHPFAADKHIRHKAQLDQQRLHVPLVDRTPAKEPPPVIVAIVGPEGVGKTTLMRSLIRRYTKHTVANITGPVTVVSGKNRRITFIECNNDINSMIDIGKIADLVLLMIDGSFGFEMETMEFLNVLQAHGFPKVMGVLTHLDLIKKTRILRATKKRLKHRFWTEIYQGAKLFYLSGIINGRYPDTEIQNLSRFISVMKFRPLIFRNQHPYFLADRMEELTPRELVKSNPKMDRTITVYGYLRGTHLRNKQPIHIPGVGDLVIQSIERLADPCPLPTQESERRRRLSDKQKLIHAPMSDVGGVMFDKDAVYINVPGHFSKRDDADMGEGERIVMSLQDSNTTLGDRAAQSELRLFDDSSAPVSLGRERRRAAFGDDMERNGSGDDESEQEEEDDAEDVDAEEEEEDDTGGGRSMNLAEDEDDEQVEEVAYAESDSDLGDAEESMSAWQTDLAQRAQETVLENRRRRRDLMRLIYDSEQTPEDIAAGRDSSSVPEESLGAEDDFLHIVSNEAPMTSVPVPEECRPQVSLDQLKVWADDNKLDSIRHLFITGNDEPDEAKALAEDGDEAEPEADQEDQQDVQDEQSSEEARAQALAAKKAALKRKFDEQYDEDEDEDKDDWYTEQKKELARQAEMNQQEFAEDDEDTRAKIEGFRPGTYVRVEIANVPCEFVEHFNPAYPVIVGGLLPNETSFGFLQVRIKKHRWHKRILKTNDPLIFSLGWRRFQSMPIYTLDDGTRNRMLKYTPEHMHCLASFYGPASLPNTGFCAFNTLSSETPHFRISATGVVLNVDAGSGASHKIVKKLKLTGTPAKVFKNTAFIKDMFSSPLEVAKFEGAQLKTVSGIRGQVKKALAKPEGQFRATFEDKILMSDIVFLRAWYNVVPRPFYNPVTSLLMRGDTEREWQGMRLTGTVRKEEGIKTPLRINSTYKPVERPEVRKFNPLRVPKSLQAALPFSSKPHTTRAQRKPTYLQKRAVVMEKDERDTVALLQQMQAVQHAKQQKRTQKRQDRMEAKNKEYEKQSAMDAQKHKERMKHIYKIEGQREAKRAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAL9</accession>
    <name>A8QAL9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728990.1">
        <property type="nucleotide sequence ID" value="XM_001728938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAL9"/>
    <dbReference type="STRING" id="425265.A8QAL9"/>
    <dbReference type="GeneID" id="5853297"/>
    <dbReference type="KEGG" id="mgl:MGL_3778"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3778"/>
    <dbReference type="InParanoid" id="A8QAL9"/>
    <dbReference type="OMA" id="LCTALNW"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08578">
        <property type="entry name" value="GDPD_NUC-2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="340"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="5">
        <location>
            <begin position="692"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="985" mass="106165" checksum="13565B011D02D068" modified="2008-01-15" version="1">MTEMSDIASASILQLESLAEGHELPTTHFKNEMALLRGALSYAATNLPGGVLLPEEDPVDGLEFASERPLDFDAEQYSETKQNNVIAELEGQLANAVHEAHMDDAKRLLEQIRKHATDSLNQSLASNMEQGHVKHDASRDVSGAVEGKGNGGGGGDGDGDGDGDGKSTGAGAGASASTTEQDTREALEAPIRSSVSHQLWRALLTSSKDAVCAAIAADLPDYSFVDDINARTALHFSTCAGQLELCKACVEHGVDPRASDVYGREALAYAAIFGFEDIAKYLLSLPESRDTHDHVVEHVDLDGFSPLLHAIVRGRTGIVRILLDFCALTGRAMQGKMENSDLSPLATAAQCGLVDITRLLLEHGAKVEVNTEGLLPQTLAARAGHTECLRLLLDAKVDVNAVEKGTLCTPLFYAAEFGHAACVEMLLAAGASIDHVDEKGRHAVFYAAWHGWRECTRMLLAAHATAAAKGAAQQQRADAGVQPMAPASTIRISESHADMDTDLDAEGDGIPSLHLPPPIIPFRTYGHNYLDKHSLLCLSLSKHSIELHRQSVSDRPDMFPGLATSFKLVLTPRNTNAGAQAGIPHTIIFPMAEEREEASFQVADLEHFYLECEIFPTFGSARIAKTVLLPELLNGLESRSHVQLPLFDWHLNLIGHIHVVLECVRPYSSVQLQIGGHVETYWKSTLPSHNQPLTVSPLPYPNGTHDAQDTALYVTASSLSGEYLNVNVHFTKDLVPVVCASRRLPVPVWAPFVSQVTATEFADIAEKTGHTWHTNESESLAMNEWSAKLSTTLVSLETLLVTLPPSVNVALQIVFDADATVVPLNACIDATLHVVYDVARREKHRRRLFFSSTMPSACVALNWKQPNYAVFFINNATLDADAAVLSLPEEADPRQSSMAEAVRFAKGNNLLGVMLDTSILECVPELITAVKAAGLVLITLRRPSSNASATDATSFSEPGFLGPPALACHDAIDGFLEGNVIKCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAQ7</accession>
    <name>A8QAQ7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Importin subunit beta-1/Transportin-1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729024.1">
        <property type="nucleotide sequence ID" value="XM_001728972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAQ7"/>
    <dbReference type="STRING" id="425265.A8QAQ7"/>
    <dbReference type="GeneID" id="5853331"/>
    <dbReference type="KEGG" id="mgl:MGL_3812"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3812"/>
    <dbReference type="InParanoid" id="A8QAQ7"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="2">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="106" mass="11381" checksum="57636CBB7E2DA38C" modified="2008-01-15" version="1">MAGKADVLLPYMDYTLAFVGLVASDSIDRSETLLRSTIGLVGDLATAYPTGPVMVKLQQPWVFEYIKLGRSRGNGTETRKTANWAREVLKKSASLGSSSSGTPILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBP4</accession>
    <name>A8QBP4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Urease</fullName>
            <ecNumber evidence="2 6">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3929</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="8">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 6"/>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728935.1">
        <property type="nucleotide sequence ID" value="XM_001728883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBP4"/>
    <dbReference type="FunCoup" id="A8QBP4">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBP4"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="GeneID" id="5853241"/>
    <dbReference type="KEGG" id="mgl:MGL_3929"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3929"/>
    <dbReference type="InParanoid" id="A8QBP4"/>
    <dbReference type="OMA" id="DTMDGVH"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050069">
        <property type="entry name" value="Urease_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0533">Nickel</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="11">
        <location>
            <begin position="370"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="561"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="8">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="8">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="810" mass="86725" checksum="89FC5FF38B8D8349" modified="2008-01-15" version="1">MHLLPRERDKLYVREIGLLAQTRLARGIRLNETEAIALISAVLQEMARSGKYTVASLMQYGKTLLGYRQVLPGISQTIPEVMIEATFNDGTFLVSVHDPICSPEGNLSLALLGSGLEAPSPDVFPRIFTPEGPVPGRIIALDSAPPITLFPDYRRLSLEMTNTGDRAIQVGSHFPLHKVNRALEFPREVAKGYKLDVAAGTAIRFEPGVKKRVTVVETGPTYRRRIKAGDSEILPGPEPFSLSRAAYASLYGPTTDDRVLLGDTNLWAVVEKDHTSYGDESTFGGGKVLRDGMGQSPGRASSDVLDTVVTNALIVDYSGIIKADIGIKNGLIAGIGKAGNPDTMTYVTQNMIIGSCTEVIAGENLIVTAGGVETHTHFLSMDMCIEGLASGLTTLVGGGTGPAAGSRATTCTPGPWHIRKMLQATDTLPVNVLLTGKGNDSGELPLREQIEAGCGGLKLHEDWGATLEAIDTCLRVCGEYDVQCTIHTDSLNESGFVEDTLKAIGGRTIHTYHSEGAGGGHAPDVIRVCGEPNILPASTNPTQPYASNTIDEHMDMLMVCHHLSRNIAEDVAFADSRIRAETIAAEDVLHDIGAISIMSSDSQAMGRIGEVISRTWRVADKMKEMRGPLISSHGKDSLTNDNARIRRYVAKYTINPAIAHGISQHVGSVEVGKIADLVLYRPKHFGVRPENIIKGGQLVMSNTGDSNGSIPTVQPVYLRPTFGFQPVCAADNSAAFVSMASIRNVGKYGLRKRCLPVSGCTGLGKKDMKLNCETPKISVDPETFVVTADGQDMKTEPATKVALSTGTGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBX1</accession>
    <name>A8QBX1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBX1"/>
    <dbReference type="STRING" id="425265.A8QBX1"/>
    <dbReference type="KEGG" id="mgl:MGL_3949"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3949"/>
    <dbReference type="InParanoid" id="A8QBX1"/>
    <dbReference type="OrthoDB" id="3360389at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="48" mass="5275" checksum="8F087148E7C2F866" modified="2008-01-15" version="1">MCGTNVIASSTDSGLEAFSHYPADDSFAPLPDRTDANTNYLNQRFLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCE0</accession>
    <name>A8QCE0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728831.1">
        <property type="nucleotide sequence ID" value="XM_001728779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCE0"/>
    <dbReference type="FunCoup" id="A8QCE0">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCE0"/>
    <dbReference type="GeneID" id="5853137"/>
    <dbReference type="KEGG" id="mgl:MGL_3998"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3998"/>
    <dbReference type="InParanoid" id="A8QCE0"/>
    <dbReference type="OMA" id="VWHRIVP"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="421" mass="47313" checksum="FC6B7BF5C2C999AB" modified="2008-01-15" version="1">MSSLYVTEPPTDGKVILHTAKGEIEIELWSKEAPKACRNFVALALEGYYDSCVWHRIVPNFIIQTGDPSSTGHGGESFFGAPFENEIHQRLRFNRRGLVAMANAGEKCTNESQFFITLDATPELQNKYTIFGRVVGSTIYNVLSLANIELSTSVPDRPVFPPKLLQAEVVHNPFRDLVPRITSAERAAQNSARSLAAERLASMERQRKKQKKNTTLLSFGEEEDVPPEPEAKKPMSSHDLLNDKRLSKQTYDFKKKDENKQNPLELQVSVANSSSQIHDEHRKSHMEESSLNKITAREKDPWQSTLSENSRSKVETNSVGKNAYAIPASTEVWGDEAHMREYGDSDDDDSDWRSHKFNSGGIPLHNSNDQFSVQDYQVLDSRDTRNPVAKSLGFGGSDSVQHQESQFRKDKIMAEGRRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCE9</accession>
    <name>A8QCE9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728834.1">
        <property type="nucleotide sequence ID" value="XM_001728782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCE9"/>
    <dbReference type="STRING" id="425265.A8QCE9"/>
    <dbReference type="GeneID" id="5853140"/>
    <dbReference type="KEGG" id="mgl:MGL_4001"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4001"/>
    <dbReference type="InParanoid" id="A8QCE9"/>
    <dbReference type="OMA" id="YAINWAM"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="236"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="508" mass="56175" checksum="189DDE33B6F61327" modified="2008-01-15" version="1">MSFHGGSAANDVDESGGVGRKGRRLSIGSFGRLGLRRSSSLRRILSETEHDSDSETSFASSAANKSASTPGTTDGSAPAVPPASSDAPAGRGFKDEDGDAAAFSSDDESTMFSNDGDEMEDEEPMFDDSTIRNTMVNAQMLPGSQNHAEITNYEDEDLLDPSADEFQTAPNIVFARNEKELLVQKTLLTKNSLPVTQPGRPTLVTHGPTLERNRCTVIMTYGDYETHSKQSRRKKRYIVASDSSEGSQYAINWAMGTVLRDGDEILIVAVIDADAKAEMYMDKYERYAGMTPSDRALQEMTIFLCHQAFVLLQRTRLNVKIGCQSVHSINARHMLLDIIDFYSPTMVIVGSRGVDGIRGMLGSMSHYLVQKSSKPVMVCHNKLQLPRLPRGKADVVKNVRMRHTRLDQAVVEKYTSKRENPEDDEEDKGESPAERMQREQLESERMNRLNRESYQRRENAGSGVGPGLGQNPSQFSSTSPVPEEVALTDEFDNKLALAPDMEKYSPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD21</accession>
    <name>A8QD21_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_4089</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728754.1">
        <property type="nucleotide sequence ID" value="XM_001728702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD21"/>
    <dbReference type="STRING" id="425265.A8QD21"/>
    <dbReference type="GeneID" id="5853054"/>
    <dbReference type="KEGG" id="mgl:MGL_4089"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4089"/>
    <dbReference type="InParanoid" id="A8QD21"/>
    <dbReference type="OMA" id="NWAVGIP"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="118"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="218"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="308" mass="32103" checksum="5914F2C99C1B9507" modified="2008-01-15" version="1">MADDLASEYIELQPKATSVASSIKSFISGGFGGICAVLVGHPFDLIKTRLQTAPPGTYSGSIDVTMKTIRADGVKGLYRGMGPPLIGVTPIFALSFFSYDLGKKLVYAATPNRTNSTLSLAELSAAGFFSAIPTVLVAGPAERIKVLLQLQGQSSSGPKYNGPVDVVRQLYKEGGLRSIFKGTGGTLARDGPGSAAYFAAYEIAKRSLTPAGSDPNDLNIVTTITAGGLAGMANWALAIPPDVVKSRYQGAPEGTYKSFMDCARKTVMADGVGALFKGFGPAMARAFPANAAVFVGVEMSQSALDMMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD96</accession>
    <name>A8QD96_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728685.1">
        <property type="nucleotide sequence ID" value="XM_001728633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD96"/>
    <dbReference type="STRING" id="425265.A8QD96"/>
    <dbReference type="GeneID" id="5853025"/>
    <dbReference type="KEGG" id="mgl:MGL_4164"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4164"/>
    <dbReference type="InParanoid" id="A8QD96"/>
    <dbReference type="OMA" id="FTIFCPA"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="76189" checksum="C9F23332002C1423" modified="2008-01-15" version="1">MENAVSKVQTVREIALANALIDFSTSMQHHCGQESEELRKLAVQSAERRLYLVEVFPDMWLHASVALARWNLKNDGDKLMPWLVDAWMHQQMEDAWHGWRLQYGPPHVLFLDQGREVLEKCLESYFSKWTWQWNVDVQYAPVLRASEPASVKSGLVGETLPTLEAVGDVSMNELAPLLAQFAAEGSTIDTAPPMDVMLLYDDKMLWPRPHSQTAAHTDLLSPPDRRQVARYVLERLVGLTSARAKADMAFAKRTKKPNSTHPSGSQGIMNDLSFMANMLGDLPSFMSLDSMWHSSDPAASMSASGPSHDTAPAPPAESPYAPEEQILNYAKSPADDQKTAKLPRLSPRIYPVQANESVTMPASSSMPKTKGTSSAFQAFHERLEQALGQHDLSTETNGITVPPSDDAARQLEEITQTFAKSSAPTRRRARLQRHESDNMRDTSRRATSWYASHQATGTMPDVNELHDYSMDGWGPETPAPWRHASLHVNAQDAEPLTTTPTTNSSVIDIVYMTRQLLTVVLVWRQDQIQAGEHGVWQLPAWDLLRRVQRILNDARRRADGKETPATSFLHVDATSALCINELTGPQHKHQKTFPSAAATAVPVPLSSGTEAQLLTAKDWMKCHGIRETLAHADNHSFWVASRASQDGMSSTFMTLEGDAQRRYGVSECDHQLRRLAAQHSEFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDB4</accession>
    <name>A8QDB4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_4177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728698.1">
        <property type="nucleotide sequence ID" value="XM_001728646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDB4"/>
    <dbReference type="GeneID" id="5852979"/>
    <dbReference type="KEGG" id="mgl:MGL_4177"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4177"/>
    <dbReference type="InParanoid" id="A8QDB4"/>
    <dbReference type="OrthoDB" id="3365304at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="172" mass="18586" checksum="28976B3208FCA4CE" modified="2008-01-15" version="1">MPTPTEELERMSAKIWELFGENVRYAAPGCTSASFPDTFKVLRALEQGAPNDADTAGITGDASNPTVPPSIGTIMMAHVLLLLMRSQAPHTLPLPMIKSYSDNWWKQEGQDQVRAGVEKPATRNPLVQQLGIDASDLEQTGDALATRAVYGLVAKKILRIQRAGGAANVRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDY9</accession>
    <name>A8QDY9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000024">
        <property type="protein sequence ID" value="EDP41406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728620.1">
        <property type="nucleotide sequence ID" value="XM_001728568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDY9"/>
    <dbReference type="STRING" id="425265.A8QDY9"/>
    <dbReference type="GeneID" id="5852926"/>
    <dbReference type="KEGG" id="mgl:MGL_4245"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4245"/>
    <dbReference type="InParanoid" id="A8QDY9"/>
    <dbReference type="OrthoDB" id="3349125at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="214" mass="24482" checksum="60AD76C3E0465B58" modified="2008-01-15" version="1">MRFYFSYGAIWGIHAAANSVALGLFYSLYVRWTWIADKFYGKKTFDRGFGNLAGQIIVPLIMIACIVAAVWGYLWIWIVFMLFVFVLWVIALVDLTKHRKSPSSRQRRTIILSAEDWKYGSSPYVTSHGQLDRMLVLLIVVMTIVLGKNVAEFVGFICLTWYFASPVHFYLSIVPEIAFAVILASPEALAMFEPERHLPGHHVPEMREANPFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQZ1</accession>
    <name>A8PQZ1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732772.1">
        <property type="nucleotide sequence ID" value="XM_001732720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQZ1"/>
    <dbReference type="STRING" id="425265.A8PQZ1"/>
    <dbReference type="GeneID" id="5857078"/>
    <dbReference type="KEGG" id="mgl:MGL_0547"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0547"/>
    <dbReference type="InParanoid" id="A8PQZ1"/>
    <dbReference type="OrthoDB" id="2574879at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="273" mass="31005" checksum="33825077DB48BC2B" modified="2008-01-15" version="1">MTDGICGYTCRTDPELDHDTQLMYVLYWMELLDLLWAARLNRAFIQLQDARTVAGASFPTPEHAHRVAAVLGTSTTLVTSRTGELALQSQPQIPALCQTDCVRLRDEILHAKEQLFGWMRDQLGVPRPPTIDDAWPEIENEQPRVEQIDTRQEELFLNDMEQKEMGLNKSTEKALDQAYGTARTAEDDDHGDMSNEEYLTDLGHKNTNGSQKAPFDEDACLQTSEIDPTCSRSGDTAKDQQDNPKADSVTDVSVRESDNHYRRLFETKVRWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR25</accession>
    <name>A8PR25_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732806.1">
        <property type="nucleotide sequence ID" value="XM_001732754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR25"/>
    <dbReference type="FunCoup" id="A8PR25">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR25"/>
    <dbReference type="GeneID" id="5857112"/>
    <dbReference type="KEGG" id="mgl:MGL_0581"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0581"/>
    <dbReference type="InParanoid" id="A8PR25"/>
    <dbReference type="OMA" id="ERTMHYL"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="271" mass="30121" checksum="A1C5C2030FA0191F" modified="2008-01-15" version="1">MALRLAARSLRSQVPSTYLSLPQVARRTLVSSCAVRSDVLFVHRDTPYNNASIPFSFVGEYEQEAKDIISKYPPQYKKAAVIPLLHLAQKQNDNWVSISAMNHVADVLEMPPMRVYEVATFYTMFNRSPVGKFFVQVCTTTPCMLGGCGSTAVLEAIENHLGIKAGHTTPDKMFTVIEVECLGACSNAPMIQINDEYYVRIFYNTHTHTHTSGSSNAEQEDLTPESVVKVLDGLARGEHVKPGPQNGRLTSAPDNKNRTLTEEVCNHRFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR62</accession>
    <name>A8PR62_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-3 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0613</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732838.1">
        <property type="nucleotide sequence ID" value="XM_001732786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR62"/>
    <dbReference type="FunCoup" id="A8PR62">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR62"/>
    <dbReference type="GeneID" id="5857144"/>
    <dbReference type="KEGG" id="mgl:MGL_0613"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0613"/>
    <dbReference type="InParanoid" id="A8PR62"/>
    <dbReference type="OMA" id="LRIHYVC"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="48"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="181"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="206"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP45624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="358" mass="40832" checksum="29A77C9126068CF8" modified="2008-01-15" version="1">MGLCGSKPEASGADQDARQRSSEIDKHLVESTKQGKQEYKILLLGSGESGKSTIVKQMKIIHQNGYSKEELYMFRLTVIKNVVDSARAIALALRLLGMEPERLENREAADILTQYEVPADPNAFLPADMGKLIESLWSDPVIPRLMERRDEFYLMDNAEYFLNSVARIATDTYIPTQEDVLHARSKTFGVSETRFQTGDMSIHLVDVGGQRSERSKWIHSFDSVTSVIFCVALSEYDQVLLEDSSQNRMAESLVLFESIINSRWFQRSSIILFLNKIDIFKQKLARRPLSDYFPEYTGGNDVNKAAKYILWRFTRVNHARLNIYPHITQATDTTNIRLVFAAVKETILQNSLRETGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRA0</accession>
    <name>A8PRA0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Afadin and alpha-actinin-binding-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732229.1">
        <property type="nucleotide sequence ID" value="XM_001732177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRA0"/>
    <dbReference type="STRING" id="425265.A8PRA0"/>
    <dbReference type="GeneID" id="5856540"/>
    <dbReference type="KEGG" id="mgl:MGL_0004"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0004"/>
    <dbReference type="InParanoid" id="A8PRA0"/>
    <dbReference type="OMA" id="YTHPARR"/>
    <dbReference type="OrthoDB" id="3361294at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37762" checksum="28F60E74B977AA92" modified="2008-01-15" version="1">MDEAATFNDIRQKILSRGYHKTPLCLDGLSEQRKVVVIKVLGALLTERDEEVELRERLLMRNKELEQSLERTKKSLRRDKLLTSELETKLLASQSETKNARTMLADEQLAHRGTKDQLLRTRKQFNQIQQASSKYRAATERQTERLKERMTTLSHASLKTLVPDIRIASPAFVARANTDPAHPGEKQILEIEKYNTALLETSTALKQLALDAFTTLYEVDIRLKDIIDVECGVEDLPFMRAPAAQKPYLGTTWDDLELHQMFPPLRPLVTDDTEYTHPARRHLTNLAENLQSHVESLSHWAAMKHFRSERLEHEHQEKRRKIDGNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRF5</accession>
    <name>A8PRF5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0041</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732266.1">
        <property type="nucleotide sequence ID" value="XM_001732214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRF5"/>
    <dbReference type="FunCoup" id="A8PRF5">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRF5"/>
    <dbReference type="GeneID" id="5856572"/>
    <dbReference type="KEGG" id="mgl:MGL_0041"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0041"/>
    <dbReference type="InParanoid" id="A8PRF5"/>
    <dbReference type="OMA" id="TWECGIP"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="173" mass="19767" checksum="7F7A37EC75F45C44" modified="2008-01-15" version="1">MSGICRTRLQEERKQWRRDHPFGFYARPEKEADGSLNLLVWEVGIPGKSNTPWEGGVYKLKMYFPEEYPSKPPKCKFTPPLFHPNVFPSGTVCLSILGAYADFLMRCSDEEKSWKPAITIKQILLGIQDLLNDPNPGDPAQADAFHLFKQDRAAYERKVRQIARELQAQGQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRK8</accession>
    <name>A8PRK8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732300.1">
        <property type="nucleotide sequence ID" value="XM_001732248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRK8"/>
    <dbReference type="GeneID" id="5856606"/>
    <dbReference type="KEGG" id="mgl:MGL_0075"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0075"/>
    <dbReference type="InParanoid" id="A8PRK8"/>
    <dbReference type="OMA" id="PTWIGVC"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="88"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="583" mass="63796" checksum="8FC45FC0EE8F69EA" modified="2008-01-15" version="1">MSNPPVHEVKEAPNFEQTGADANNDVEVQHVNVLGDVQAGKNDPEEDFYHAHDHLESSAVDEVYVRKVYIMNKIINEHIGMTWWQYGLLLVSGVGWFLDNAWLQLVAVVLDPIHKEFLSNDETYGGKNSAMMTLALYAGLVVGAAFWGFAADIVGRRFSFNATLLICGIFGVACGGAKSFVALGGLLAATGFGIGGSLPVDGMLFLEFLPGARQQLLTLLSVFWPLGQLATSLIGWGFIATWSCNDDVDCMALPKNSRGWIEANVGWRYTFFVTGSYTLLCFFLRFVVFQIPESPKFLISKGRDGDAVRAMHRFARICGKPLPEGLLTVASLKAAAGQEIDENEVIEEENEPPKNLADRIMMPVHEMALNFRNSHPGEAFSHLRPLFSTFAMGYTTAILWTLWAVIGLAYPLFNAFIVLYLKGGGDESISKTYRNYVIISVCGIPGCLLATWLVDLPRSGRRGAMAIGTLLTGIFLFGFTGVDGTNEDGKLGFFCVTSFTQNIMYGVLFCYTPETFPAPLRGAADGVGSSLNRLFGLFAPIIKAYQKKGSNKSIPLYISAALFLLCGLLMFTLRVETASRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRP4</accession>
    <name>A8PRP4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732323.1">
        <property type="nucleotide sequence ID" value="XM_001732271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRP4"/>
    <dbReference type="FunCoup" id="A8PRP4">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRP4"/>
    <dbReference type="GeneID" id="5856629"/>
    <dbReference type="KEGG" id="mgl:MGL_0098"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0098"/>
    <dbReference type="InParanoid" id="A8PRP4"/>
    <dbReference type="OMA" id="IAFIPHV"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050085">
        <property type="entry name" value="AGPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338:SF10">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="56"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="612" mass="67845" checksum="0CF22274BF6F1AF7" modified="2008-01-15" version="1">MKEEWVKYGTKLKLREIKELLDHLPRSSSVAIISVDQLQKELFTDSGAGTLVRRGYKLFRSSSIQDIGAERLRAMLREHDDDVRENRKSASQIFSELSQTPYTVYGDEGLGCVAFVSHPPDEVPVLTRLVMTRDAAMNHVIDNIWGMIRKDYRRLVWTSRADDENRAWHFEHADGSFTRNRRSLYYYGIQDVGEVERTMRQLEEKGRIERAYLPLNMRRVPSGTARGFCTYTHASTKLPQQGRESYTLGRRTYATTAEPKRVALIGARGYTGRSLVQLINAHPNLALSHVSSRELAGLPLDGYTKEQVYYANIGPEDLKKLESGRSSVAPPDAYIMALPNGVCRPFVDAVREGGKGKAQGHGVIVDLSADHRFDDAWTYGLPGAFATASQLYSREAIQQSKLISNPGCYATNTQMLLAPLLPYLDATRPPTVMGVSGYSGAGTKSSGKPSTPGERPVTLPKLDPETLHGAVRPYALTDHIHEREARYHLTKLANGTPVNVAFTPIVAPWFQGIISTASVPLSTKLTAREIKQLFEEKYQGEKLVEILPHVPEITDIALKHGFKAGGFQVHSSGERVVIVGVIDNLLKGAATQCMQNLNLALGLDEFAGIPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRP6</accession>
    <name>A8PRP6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732324.1">
        <property type="nucleotide sequence ID" value="XM_001732272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRP6"/>
    <dbReference type="GeneID" id="5856630"/>
    <dbReference type="KEGG" id="mgl:MGL_0099"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0099"/>
    <dbReference type="InParanoid" id="A8PRP6"/>
    <dbReference type="OMA" id="RIHELHQ"/>
    <dbReference type="OrthoDB" id="2536714at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="694" mass="76117" checksum="72FFBEBEA77535BA" modified="2008-01-15" version="1">MGLGYERRPTTPSRPMSSQQQQQWKQGEQLDMKLPPSSLPRSSGFDSLQDLLEREGYKETRIVTPKIPHVITIDDADDMGLVAEDKPKHARSSLKPLHESATNVNLQRSPDKRQDIERWMQGIMSSNQESVSKSQTKKTKTKPSKTSDMHVLRTSQSDHALKRRPLRRKSSIWDASVAYRHSSNTGADTPPVPKLPLGPSVYPYPPVPPVPAIPSQFKKTAPATEVSAAATVPSSQLTVDATPALGFLSSPAKPVLSRKDAVVQVYDTDSMVLPRGLRRSKSEDLLHKALKSRRMQRADSFPVCNCGRDGTKVPIEPRWHTQVCPVRLRWEATMPGPVPPPPPQLFVSTPNGISTPKHLDLKGTEYDPLDTPSGFAQYFPFSRPGFHLAKRATLAGLHGLFKSHEKMSQDISALRRPVPTSQAPQPPSIQRRSSKHRLSRCKSLPQLSPSSAKQTHVTDASLARGDGEPVALTGSRRIHELHQHVQDRMKQDDSTSACESAFSTIQSNDVGTEASSATINANGIDVIDPDAEMSGKSPSACTSESPSLRRARSRTHLNRRINSTTHSCVLPVLSDSLTNEGPASGLPALNDIPNVHGPSSVPLGVNQQAPESLDESNPMSYVSPVTTTAPVDMLKMQPQRLVRRSSKMRPPSENKRSDPSIHHALHSVAGSSTLSDKHRRPMRPVPSHTKNVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRU7</accession>
    <name>A8PRU7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732357.1">
        <property type="nucleotide sequence ID" value="XM_001732305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRU7"/>
    <dbReference type="GeneID" id="5856663"/>
    <dbReference type="KEGG" id="mgl:MGL_0132"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0132"/>
    <dbReference type="InParanoid" id="A8PRU7"/>
    <dbReference type="OrthoDB" id="3360074at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727060" evidence="3">
        <location>
            <begin position="21"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="220" mass="22742" checksum="E85C1D772F4C6634" modified="2008-01-15" version="1">MVKLSVPLSLLAVAVASVVAQQDGQQQSSQPQQQSSQPQQQSSQPQQQGSQGGGGQQSQSPKPTSAANQGSGSGSEGDDKNSRTSPVCSALFGDPNVHQVGSCSHSSTVVPPYNLGSLVSYMIGGYTRSRKDAGMVVDVADELAESVVKYYPTVTQSSDVIKYSMYRGLLRSIRANDKDFDPSDEMKRPPGAEPDNGAAALVVPGAVGVAAAVLGGAIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS89</accession>
    <name>A8PS89_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Solute carrier family 40 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732439.1">
        <property type="nucleotide sequence ID" value="XM_001732387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS89"/>
    <dbReference type="GeneID" id="5856745"/>
    <dbReference type="KEGG" id="mgl:MGL_0214"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0214"/>
    <dbReference type="InParanoid" id="A8PS89"/>
    <dbReference type="OMA" id="FNNAPYW"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727067" description="Solute carrier family 40 protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="68424" checksum="EE48783E1726DEA3" modified="2008-01-15" version="1">MPTLALLVIPHLLGLIQAVQIPAEMDAIRSLSCAHYYYLNPEQKNQEDDNAIDATSCLRPEVEQHFSKIATFVTFSVVLANFVGMLIWVRRFDPKRRRSMAAKGMCGSALARVPFLVLPLYQFPFLAPPNVLSLSPSTMLLVFWACAVLGGLSGTNELVSLTVESFITDSSSPEVRSQLLRYAQVATLLGASLGPLLGSMSTWIFPNAHNACIGYRTCQKNRLVFGRAVLFNNAPYWLAFGISLLGWTWVWFALASSGTGDGLGRDDLDETSSLADSTSVDSSTRASRNRPTRRDTAEWGASLGAFQRLLPVRMSRWSYDTRILQFTAADMCIALTQEGPVALIFVLGFVFRWSRDALSVGLAVFNSLRLVHMAILLPIVLHRIVWQGSKPAPISELTPKQLDACFSVTKEAFDRPRRRRDSFDSIASLQHILDHVSSEQYELARLWRAQVDLHASRISFFINATSWMTIFAGVYLTKQWLLMAGATALAFGCGAQFLLRSAACTICDSIVDKRAESLQLHLPTSNTHTDAHSPTLSPTGPVASSATSRPKPLPSGSDSYLVISSTLMLPCLLLGLCLRNEIYTRTLATNPGAFFIVIAGIETLGLLALCPIQSASITTSSTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSQ6</accession>
    <name>A8PSQ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732524.1">
        <property type="nucleotide sequence ID" value="XM_001732472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSQ6"/>
    <dbReference type="FunCoup" id="A8PSQ6">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSQ6"/>
    <dbReference type="GeneID" id="5856830"/>
    <dbReference type="KEGG" id="mgl:MGL_0299"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0299"/>
    <dbReference type="InParanoid" id="A8PSQ6"/>
    <dbReference type="OMA" id="MSKANRP"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="140" mass="15371" checksum="21F45585BB468271" modified="2008-01-15" version="1">MSKINRPPVSVSRVMYLSRNQGGIAKDASESPKTVVVVGTITDDNRVLEVPKLSVAALRFTNTARARIEAAGGECLTLDQLAMRAPTGSNTILLRGPKNAREAVRHFGFGPHKHKKPFVRSKGPKFQKARGRRKSRAFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSR8</accession>
    <name>A8PSR8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732530.1">
        <property type="nucleotide sequence ID" value="XM_001732478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSR8"/>
    <dbReference type="FunCoup" id="A8PSR8">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSR8"/>
    <dbReference type="GeneID" id="5856836"/>
    <dbReference type="KEGG" id="mgl:MGL_0305"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0305"/>
    <dbReference type="InParanoid" id="A8PSR8"/>
    <dbReference type="OMA" id="RITIEAC"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="141" mass="15195" checksum="7709DF9BB0E2F617" modified="2008-01-15" version="1">MPPKPAEKKPPSTAGKAPASAGKAPTEGAKKTSKAPTKSSEKKKSSSKVRKETYSTYIYRVLKQVHPDTGISNKAMAILNSFVQDIFERIASEASKLASYNKKSTISSREIQTAVRLILPGELSKHAIAEATRSVTKFSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSV3</accession>
    <name>A8PSV3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732547.1">
        <property type="nucleotide sequence ID" value="XM_001732495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSV3"/>
    <dbReference type="FunCoup" id="A8PSV3">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSV3"/>
    <dbReference type="GeneID" id="5856853"/>
    <dbReference type="KEGG" id="mgl:MGL_0322"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0322"/>
    <dbReference type="InParanoid" id="A8PSV3"/>
    <dbReference type="OMA" id="IEWTNEF"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="122"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="396" mass="43759" checksum="20FD0DCB8A2DFCA3" modified="2008-01-15" version="1">MSIKYEKNDKLKQLIRAKFVEYLDRAEKLKEHLGKVAQVENADGGGGSGKSTIGASSSKGDTDDMDAETRKLRSGLSNVILTERPNVSWDDVAGLSSAKDALKEAVILPIKFPQLFTGKRKPWSGILLYGPPGTGKSFLAKAVATQSNSTFFSVSSSDLVSKWMGESERLVKQLFAMAREARPSIIFIDEVDSLCGTRNEAESEASRRIKTEFLVQMNGVNNDDQTDVLVLGATNIPWALDSAIKRRFEKRVYIPLPELDARRRMFELNIGATPCNLTHKDLRTLAAETEGYSGADVAVVVREALMQPVRRVMNATHFKLVLETADDGSMQEKYTPCSPGDPDAREMTWMDIASNELKEPVLVMNDFLRALHAVRPSVSAADIQKHLNFMQESGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT31</accession>
    <name>A8PT31_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ROT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein rot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732584.1">
        <property type="nucleotide sequence ID" value="XM_001732532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT31"/>
    <dbReference type="FunCoup" id="A8PT31">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT31"/>
    <dbReference type="GeneID" id="5856890"/>
    <dbReference type="KEGG" id="mgl:MGL_0359"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0359"/>
    <dbReference type="InParanoid" id="A8PT31"/>
    <dbReference type="OMA" id="IWQHGKY"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="190" mass="21807" checksum="52E8F19A72B63A3C" modified="2008-01-15" version="1">MTKVFALPSAMDTSLNGTWTSGNGDVVTGQDFYNLVNKTFNVPKTTGISYSFLSTNETSGFWEQALYQYSRNDGPDCYTLQLVWQHGNYTIHPNNSITLDPFKADGLQQFTNTCNHDKDRVEYYAQQEFMQGFDITTYKHLLADDAQWSYKLQLYNYDGSLKTPMYLAYRPALMFPPSPLHMTMIGFNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT40</accession>
    <name>A8PT40_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal RNA-processing protein 12-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732588.1">
        <property type="nucleotide sequence ID" value="XM_001732536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT40"/>
    <dbReference type="STRING" id="425265.A8PT40"/>
    <dbReference type="GeneID" id="5856894"/>
    <dbReference type="KEGG" id="mgl:MGL_0363"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0363"/>
    <dbReference type="InParanoid" id="A8PT40"/>
    <dbReference type="OMA" id="ANNEANH"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48282" checksum="9884D0C0093AA44E" modified="2008-01-15" version="1">MMGASITALARLLYEFHTSLPTEMLSELLATMLVYLESTNREIAKGALGFCKVAAVVLPAQHLEPSLPELVPALLHMRTVHKNHFKTQVRHLIERLLRRFGFDAIQAHVDIENQRLISNIRKRKERAKRRRSQTSSSNPEDEELDGNVAMASFGSLGVHGRPARGRGTDGMDAFEDALYGSDSDDDDDSGDDDSDYDEKDRRRQPQAQGRGNNKKKQPTAETASRRTRHREDDAFLLEDDDAPMDLLDEAAVGAIRTNVRQKTRRQPGQEARTFETDDAGRLRITDEDDARMDDDATAAAAAASAEDEAARRYEGTAFMEKSMGVDGFTHRGRGGAVKFNKNNKRTRANERMDDELDDVDANNEANHGRASVPPARRGKKRGKEAIGSEFRAKRAQGDVQKGGMSPYAYVPLSSVSGKKAKDASKLAITGKRRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTI8</accession>
    <name>A8PTI8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0431</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732656.1">
        <property type="nucleotide sequence ID" value="XM_001732604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTI8"/>
    <dbReference type="FunCoup" id="A8PTI8">
        <property type="interactions" value="516"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTI8"/>
    <dbReference type="GeneID" id="5856962"/>
    <dbReference type="KEGG" id="mgl:MGL_0431"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0431"/>
    <dbReference type="InParanoid" id="A8PTI8"/>
    <dbReference type="OMA" id="NIIFCHQ"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="12">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="830"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="137"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="328"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="626"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="937"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="833"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP45442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1164" mass="132388" checksum="8FD1326CD52C30FC" modified="2008-01-15" version="1">MAGTDTVKAQVRLRFRNTSGTRMSCVRNLQVTKKKGGGLTMKTLEGVLGIDDDAADPQARASISTRCAELDQEMASLLGVSHAILENVLFCHQEESNWPLSEPAILKKRFDEIFEVSRYTKALDSIRALRKQRAQDARVDEAELRALQNEKERAENIRATIRTLEASLSAKKNERDDLDAAIQRKTTENQQLYDDATRFREVVNQAEMLEEKIALCEEHKASLLSRMTLLAMPDSELQDELTALPTQLETQHARLSHVRSNMQVYVDKRSSAAEEHERLVRRHAELETAERTRQRVLQATAKELRTFGSDISSAPTKAQFDACSTMCEASLREKLQEHEIKAEQHQRAADELESQALTEYEHLETRLRDLKSQREHTGASLQRLHERIMSCENQLARQASTTSVCELDKARERLAELGSVSLPDVQEAMEHLATLEAERDAIATSFVDSQQDTKHVARQEELASKLPVLRERENLWRQMCVERLGHVPKNLEEELEQAEHVLDQSQAQLLKASEQVVQWATTVDVYQDVLSRSEKLCSSLRVAKQTLLGDFASVDAGLVTVQEEIQVLQESLFLLEHASAFFERIQHHAHARHMCLACNRDISSSQLQSVDAHIEETRQRKQPEKVAVLEQDLDAWNRQLSNLYAARAIEKQLREQQEPELSRLVAQLEDAKKCHQDAEGERDRSSGATASAVARVKTLRSLQVPMYRLVDLRLDVQLLKRQLDSIASTSASATTSNASPESLKALSQEIHAQQAHCHELREQCDQHRNRVREAERHVHALEMQLMTEQQHAAATQTAHQRLEEYMADAKDLEKQRETLTFTINELTQPLSEAQKHLEDTRRERREQEERYKEKRSDLEQQLAKLAGMVQRVSSAWDEAEADGGTLVSCSIELDRAAQALQHTQKEAERATQDTYALETAIHDVRAREANLQDNMRYRQVLRELEHVTAELNKLDLEAAHMRHKRASSAYDAARREENELSGRAAHIRGEIQGIEAELQRREAELRHDYKDISNRYMRQLVHIKVAGMANHDLDIYCGALQQAILQYHAIKMEEVNQTLDYLWKKTYQGTDIDSISIRSDTEGRVSANGLRSYQYRVCMVKDAVELDMRGRCSAGQKVLACILIRLALADSFGGSCGFMALDEPTANLDRENVEGLAASLIEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU14</accession>
    <name>A8PU14_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KHDC4/BBP-like KH-domain type I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732737.1">
        <property type="nucleotide sequence ID" value="XM_001732685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU14"/>
    <dbReference type="STRING" id="425265.A8PU14"/>
    <dbReference type="GeneID" id="5857043"/>
    <dbReference type="KEGG" id="mgl:MGL_0512"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0512"/>
    <dbReference type="InParanoid" id="A8PU14"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="2">
        <location>
            <begin position="65"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="263" mass="29399" checksum="27496093DB1D5935" modified="2008-01-15" version="1">MLRPNEPPLYLHVTADTRESLNRCIARINNLMMQDLPPLLDDRLHRNDPRASNEEIVPINLEPLRNFNVRAKVVGPSGLFVKYIQHETRVRVQIKGRGSGYLEGDTGRELQETMHIHLSGPESVQVRRAKEMALDLVDAVTQEWHKARAALGGQDSGRNEDAPPPPPPSEPAPPPPPEGAEVPPPPEDEIPPPPPTDAPPADPEPPVTEAQTESAMLEEDEEEAALQQYWKDYVAWEQSFVNYHGRRPTKEEGAQDVPPEHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU92</accession>
    <name>A8PU92_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_0638</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732045.1">
        <property type="nucleotide sequence ID" value="XM_001731993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU92"/>
    <dbReference type="FunCoup" id="A8PU92">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PU92"/>
    <dbReference type="GeneID" id="5856372"/>
    <dbReference type="KEGG" id="mgl:MGL_0638"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0638"/>
    <dbReference type="InParanoid" id="A8PU92"/>
    <dbReference type="OMA" id="CSWVVNQ"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP44831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="361" mass="41596" checksum="7D68FB031100F5C5" modified="2008-01-15" version="1">MSTVDQKLVKRQRFEHVFSQIVEELLEFLKTQKMPEEASTWFKRNLEYNTPGGKLNRGLSVVDTVEILLCTDEHGQKTRELTESEYVQAAVLGWCVELLQAYFLVADDMMDASITRRGHPCWYRVDGVGNIAINDAFMLEAAIYHLLKTHFKSESYYGHLLELFHDVTFQTELGQLIDLITAPEDVVDLSKFSPEKHRLIVVYKTAFYSFYLPVALAMRMCHVNDEAAFKHAQDILIPLGEYFQIQDDYLDCYGAPEVIGKIGTDILDNKCSWNINVALSHATPEQRKVLDENYGKKDAQCEQRVKDVFNAENIDLPAKFATYERESYDRIHSLINAVPESFGVKRAVFLSFFDKVYKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUV0</accession>
    <name>A8PUV0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732185.1">
        <property type="nucleotide sequence ID" value="XM_001732133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUV0"/>
    <dbReference type="FunCoup" id="A8PUV0">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUV0"/>
    <dbReference type="GeneID" id="5856491"/>
    <dbReference type="KEGG" id="mgl:MGL_0778"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0778"/>
    <dbReference type="InParanoid" id="A8PUV0"/>
    <dbReference type="OMA" id="YRGRATY"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="93"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="215" mass="23590" checksum="5E7598884B112CF6" modified="2008-01-15" version="1">MLAGKSGAEVGAEEPHREADFAHEYLENDVANEGREADAEDADIEAMKRRVAEMEAEAAKLREMNEVAERDISGTASAASHPSEEEKMEVDGRSIYVGNVDYGATPEEIQQHFQSCGTINRVTILCDKFTGHPKGFAYVEFADSSFVENAAVLNESLFRGRLLKVTPKRTNVPGITTRGRGRGRGRGGFRGGPRGGFRGSFRGRGSWRGRGHGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUX7</accession>
    <name>A8PUX7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732201.1">
        <property type="nucleotide sequence ID" value="XM_001732149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUX7"/>
    <dbReference type="STRING" id="425265.A8PUX7"/>
    <dbReference type="GeneID" id="5856507"/>
    <dbReference type="KEGG" id="mgl:MGL_0794"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0794"/>
    <dbReference type="InParanoid" id="A8PUX7"/>
    <dbReference type="OMA" id="IELRIHI"/>
    <dbReference type="OrthoDB" id="3357813at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52529" checksum="8725C217F1DD65C6" modified="2008-01-15" version="1">MFEIVPRSDAASFQTGYLGVNGLSAWIIGDVLTKLDVSETEASYFEKCTVSWSAAERVKNNKALQLYHDEQVIWNRNDDAKARIPSILPFQFELTDDLPQCSHVPGCQLTYQIMAHLHHTQGRDLHAEAPFHPRRYIMSGWNSLLVHANAGQGHAASRNSGEVEYSLDPVQWKMNTVAPAYFWLNRTIIRHVDPLRLQAHIPPPSELLVVEKGLQLQSVSAHLTRIIQSHPQGRVYSDEKLLQYLSDAEPTEISRVTSQSQLDEDAVHPYLRQHHVAYTGKSCRFHSKRPIHLCFALFPGSILGSALAVGESFNLLATNHELGGDMICESITQDTALQNVRFVLTIRVVIKNEKGDHRDIVTRKLIKILPSPAGTSSTLNTSNQAHGEPEKPYSTASGESLPQQVLDAFAHPNEYDGYDDSIQEGNSMRAMTLTNPVAFNQLSRNTSTVEIMCNLHLLSLPCNMTVIASPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV06</accession>
    <name>A8PV06_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase SUV3, mitochondrial</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0811</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP45004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732218.1">
        <property type="nucleotide sequence ID" value="XM_001732166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV06"/>
    <dbReference type="FunCoup" id="A8PV06">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PV06"/>
    <dbReference type="GeneID" id="5856524"/>
    <dbReference type="KEGG" id="mgl:MGL_0811"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0811"/>
    <dbReference type="InParanoid" id="A8PV06"/>
    <dbReference type="OMA" id="CTVEMFP"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001549">
        <property type="entry name" value="SUV3p ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="188"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="587" mass="65896" checksum="3E0F65AF916886C3" modified="2008-01-15" version="1">MQLDVLRSITDLRAPSLTYSSARSLTRQIHLHVGPTNSGKTHGALVTLSKARTGLYAGPLRLLAHEVWERMNQGTISPSIQPRACNLRTGEEVRVVDEYAGLVSCTVEMADVTRAYEVAVIDEIQMIADIQRGFAWTQAVLGLPAKELHLCGEASAVPLIQRLVEMCGDELHIHNYNRLSPLHVASSSLRGDLTKVEPGDCVVAFSRSTIFWLKEQIEARTGLQCAVAYGALPPEIKSEQAKLFNSGKLDVMVASDAIGMGLNLRIRRVIFDTLSKWNGKEQVPLSLSQIKQIAGRAGRYGTSRDKNEEPSGLVLTRNENEMEYLRAALAAPVRPITHAQIQPSTRKLESLALLLPRARTRGPSSSRRRVSIHDNSVSTLLEEFHAFADLDAGVFSMADFVSQKAMSTIIEHRGRDRLTHAEKEKWSNTPVNMRDERAVAWVGNAIERYARGELVRFEACAKELGTMEAEEAIAQIMRDAQTRHKVAGSEQSVVMFAQQDETVLNIHTLMLLESLHRTLTLYLWLGFRFPLAFCFRHDVEARKQRTEASIEFCLEAIRVRRAQRLTRLGRKEEAHVLLKKHVHRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVE3</accession>
    <name>A8PVE3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731572.1">
        <property type="nucleotide sequence ID" value="XM_001731520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVE3"/>
    <dbReference type="STRING" id="425265.A8PVE3"/>
    <dbReference type="GeneID" id="5855878"/>
    <dbReference type="KEGG" id="mgl:MGL_0840"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0840"/>
    <dbReference type="InParanoid" id="A8PVE3"/>
    <dbReference type="OMA" id="MCAERCA"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013171">
        <property type="entry name" value="Cyd/dCyd_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08211">
        <property type="entry name" value="dCMP_cyt_deam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="62" mass="6519" checksum="092C8139493A0D5B" modified="2008-01-15" version="1">MTPEQESTLIEQAIDAKTLSYAPYSAFRVGAAALLEDGTIVQGANIENASYVLGQVFLGNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVF6</accession>
    <name>A8PVF6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731581.1">
        <property type="nucleotide sequence ID" value="XM_001731529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVF6"/>
    <dbReference type="STRING" id="425265.A8PVF6"/>
    <dbReference type="GeneID" id="5855887"/>
    <dbReference type="KEGG" id="mgl:MGL_0849"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0849"/>
    <dbReference type="InParanoid" id="A8PVF6"/>
    <dbReference type="OMA" id="VAWIHEW"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="71" mass="8172" checksum="911982DFE3594F5E" modified="2008-01-15" version="1">MTLPFSRYSEKKIAENNEAEILGVVEEEARNGYAEEAIVVLPSEKADQLESHTERVVAWIHEWRRQRGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVG2</accession>
    <name>A8PVG2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731587.1">
        <property type="nucleotide sequence ID" value="XM_001731535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVG2"/>
    <dbReference type="STRING" id="425265.A8PVG2"/>
    <dbReference type="GeneID" id="5855893"/>
    <dbReference type="KEGG" id="mgl:MGL_0855"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0855"/>
    <dbReference type="InParanoid" id="A8PVG2"/>
    <dbReference type="OMA" id="YEWDTPA"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="8">
        <location>
            <begin position="124"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="487" mass="51932" checksum="9D88AD1DFEC36F21" modified="2008-01-15" version="1">MSVAASIHIQRSNTSTSVLEAAAALNDAAQVGAARQAAYQVRPMNDTHNRAPEGQAPVEALTSSVSAAPAGAQTQHGPRNVSSFAADASSDSAPSTTMSSFKQAEHKLLMIPGPIEVADDVLLSNAHPSMAHVSPDFIPVFGESIEMLRQVADAPSSQPFIIAGSGTLGWDLAAANLLEKDDDVLVLSTGYFGDSFAECIEAFGGKPKQLSAPAGSRPNLDEFASLLKEKKYKAVTITHVDTSTGILMDVPAVTNVVKSVSPDTLVILDGVCSVGSEEIHMDAWGVDFLLFASQKGIGIPPGLSLSLASPRAIQTFQKRSSPPAGFYTSWKKWLPVMKAYEGRTPAYFATPPTNLIYALHTSLKTMTQGQVSLSQRFQMHRDASKRVKKAIQDMGLEQLALPDSREDGVANGMTAVRYPKGLSAPDILPKMAQRGVVFGPGLHKDCKNEYFRIGHMGISVVDPSRGDIDTILKKLEEVLVEAGHKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVJ6</accession>
    <name>A8PVJ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0888</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731620.1">
        <property type="nucleotide sequence ID" value="XM_001731568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVJ6"/>
    <dbReference type="STRING" id="425265.A8PVJ6"/>
    <dbReference type="GeneID" id="5855926"/>
    <dbReference type="KEGG" id="mgl:MGL_0888"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0888"/>
    <dbReference type="InParanoid" id="A8PVJ6"/>
    <dbReference type="OMA" id="SWHPHTM"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="422" mass="50487" checksum="2DB8A51685C96675" modified="2008-01-15" version="1">MGAGDLNVKKSWHPRLQKNQEKVWLHEQEAAAENKKLEELRKEREQERQMQELQRIHEAAGGKRRPERVEWMYATPATSSGPSEAELEEYLLGKKRVDKLLQGNETARLSRTSDPSAQESSDVSSARDLAQKIREDPLFAIKKQEQAMQEMLMKDPTRLRQMRARLGLPDDEPRHNHHSHEERSRHRHRHERRSHHGRVSRSHARRDDGVGEREYCEGRHRRHREHSRRYDEGDRRKDDRYRDARNEDRHAHDYDRNKRHNDDHYRHRHVREDGRYPAHDRHSWQDERGRRPNWEERNERHSHDTLSRQRSRSPDDRQRVVDAQEREAKLAAMMQDAKTMDANRDAMIRHVSEQENREHQEEEKRRDLAHDKTQWRKGGGTGRASFLIDQQRNLWGESSGGMDLEERLRRSRHALQPVGDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVK3</accession>
    <name>A8PVK3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731625.1">
        <property type="nucleotide sequence ID" value="XM_001731573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVK3"/>
    <dbReference type="FunCoup" id="A8PVK3">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVK3"/>
    <dbReference type="GeneID" id="5855931"/>
    <dbReference type="KEGG" id="mgl:MGL_0893"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0893"/>
    <dbReference type="InParanoid" id="A8PVK3"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="32"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="487" mass="51664" checksum="D0B8149C95AC60CA" modified="2008-01-15" version="1">MYAIVRQQMLRAGSLMRTSAAYLHTSTAARELSKFTMPAMSPTMQDGGIAAWRKKEGESFNGGDVLLEIETDKATMEVEAQDDGVLAKIIADAGSKNVPVNSTIAIIGEEGDDLSGADALAKEAESESASASAGEAEKAAKQEESAKEEESKQKEAKSEEEDKPAAPKPRESDDSGTASKLASMDHLSASPIAKRIALERGIPLLQVKGSGPNGRIVKEDVEKFASGSGAAAAAATASTAAAGGSAPAYTDQPLSNMRRTIAKRLTESKSTVPHYYVTFDIEMARVLQLREVFTRASAEAARGDEAKAKQAKLSVNDFIVKAAALALKQVPAANSAWHGEYIREYHTQDISMAVATPNGLITPIIRNCGAIGLTEIGKQSKELAKKARDGKLKPEEYQGGTFTISNMGMMGTSHFTAIINPPQSCILAIGATEARLVPDESTDKGFRTVQVMKATISADHRVVDGALAAQWMQAFKAALENPLSFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW57</accession>
    <name>A8PW57_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intermembrane lipid transfer protein VPS13-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731762.1">
        <property type="nucleotide sequence ID" value="XM_001731710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW57"/>
    <dbReference type="STRING" id="425265.A8PW57"/>
    <dbReference type="GeneID" id="5856067"/>
    <dbReference type="KEGG" id="mgl:MGL_1030"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1030"/>
    <dbReference type="InParanoid" id="A8PW57"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="2">
        <location>
            <begin position="159"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="361" mass="40289" checksum="4C1B3E6159C34CC6" modified="2008-01-15" version="1">MFYEPYYGLIMHGNRELGFGIARGASNFVKKTVFGVSDSVSKLTGSISKGLAAVTMDRDFQSRWRAKRFRNKPKHAFYGIATGANSFLTSVASGIEGLALRPLEGAEDGGASGFMQGLGRGLVGALTKPAAGAFDMASSITEGLRNTTLVFEQNSIDRVRLPRFIASDHVVRPFSEREALGQMWLQTMDAGRLVRDEYVAHINTPGPHGGATIMLTETRILYVRTAHLKALWEVRVVRSEHNLARKQWHFARTPRWGSRPLSHHSGRKHTSVAIPSDLRRRAEIQRRSCLDDRHPCILSCSSPILPVLFVFASCVTRNAWATLLRFRSLAQQRQSPYLHIRSSHPTDTHVSAHAQYHVIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWA8</accession>
    <name>A8PWA8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731791.1">
        <property type="nucleotide sequence ID" value="XM_001731739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWA8"/>
    <dbReference type="STRING" id="425265.A8PWA8"/>
    <dbReference type="GeneID" id="5856096"/>
    <dbReference type="KEGG" id="mgl:MGL_1059"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1059"/>
    <dbReference type="InParanoid" id="A8PWA8"/>
    <dbReference type="OMA" id="VLHQYTE"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="53325" checksum="5159805E2F3EB686" modified="2008-01-15" version="1">MFGEPRLMLTDPVGLDHVLRKRAYAFPKIRLAQRLIGGVMGNGLLVAEGEVHRRQRRAIQPGFHSRAIKRLAPVFQQHAFNLLAYLRTQTREHDSQLIDVYTPLSAAALDALGDGALGASFGALASLIVHPSGIVHAAHPLTAALDRTLRIASHPSKYALLMDTATLYFPILEHIPIGLSSHAFRREARVLFDLAGSIVDDAQARIRCETHDTSPDILASLLRANANAKRARSGEKKHSVLDHAILTDAELHAQVSTFIFAGHETTATQMAWLLLFLAKDQRRQQTLREAIGAKRAALGLMPHARAEPTEACERALSAEELEDIPYLDWCVRECLRLQAAIHTTSRVATDTDWIPLSSGRSIQVHRGMIVLIPLTSIMTSEHHWGADPEEFRPERWAEPTLKGPRAFPAHNGLSFLMGPRACIGSAFALLEMKVFIATVLSELYFEWDGRPIVPKLWVVARPFDASCQQDACILKIRRISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWU1</accession>
    <name>A8PWU1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731949.1">
        <property type="nucleotide sequence ID" value="XM_001731897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWU1"/>
    <dbReference type="STRING" id="425265.A8PWU1"/>
    <dbReference type="GeneID" id="5856254"/>
    <dbReference type="KEGG" id="mgl:MGL_1217"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1217"/>
    <dbReference type="InParanoid" id="A8PWU1"/>
    <dbReference type="OMA" id="CHEFFIA"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="319" mass="36074" checksum="839C0DC292C097BF" modified="2008-01-15" version="1">MDSSSAELSQSGQHDAHEMFISALNGIHNSLTAHALERKKLPACPWEGEHMLEHLHEHAEQPSGARVPNRAVDHVAQCPCVIHRTFCGRLQSSVTCLACSKSTHTREPFLDLSLQVYPMETNEPDDSKKKRTVAADSKKREKGTPVAETSAQSLYASLLRYCAKEQLPEASYRCSHCLQSSKATKQLHLYQLPPVLCIQLKRYEHGIGTSKVDARVHFPLVLDVRECCTGAQETDESMDPFAYAYDLFTVVVHQSTLTSGHYTNFSKWRDAWYRYDDDKVTRASIAQVLEARAYQLFYLRRRLRNQPSHGVHTLSKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWX4</accession>
    <name>A8PWX4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731982.1">
        <property type="nucleotide sequence ID" value="XM_001731930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWX4"/>
    <dbReference type="FunCoup" id="A8PWX4">
        <property type="interactions" value="669"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWX4"/>
    <dbReference type="GeneID" id="5856287"/>
    <dbReference type="KEGG" id="mgl:MGL_1250"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1250"/>
    <dbReference type="InParanoid" id="A8PWX4"/>
    <dbReference type="OMA" id="YGQRRGW"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="101"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="398"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="475" mass="53501" checksum="CA6322356E79BFA7" modified="2008-01-15" version="1">MLGARKVLTLQVDREGKPQYDAIVQQGRREGQRVQSQFKDLVPLSEREDVRDRNRSIERPSEEQVSSTAESTRKALEAIVHGKVKTAQPKNVSRTSSNISYLRYTPASQNADGKKQRIIQMTEVVEDPLEPPRHMFKKVPNGPPSPPPPVLRSPPRKVTAQEQKEWMIPPCISNWKNNKGYTIPLDKRLAASGRGMQDVHVNDNFAQFSEALNLADRHAREEVRQRNLMQQKIAAQEKAAREESLRMLAQRARDERAGFSASSSSRDRLSNERSVQSASLTAYGSSESDEEDDEEEVAQRNKLREERRREREREMRMSNMGKEQRARVFAKEQNRDISEKVALGLAKPTMSKESMTDARLFNREALSSTFGDDDSYNVYDKPLFQGSSAAAAIYSRPGSGGGADDMYGGGTESGIRDELQHDRFGLGARKGFSGAQSQEPRSGPVQFEKDTNDPFSIDKFLDDAKRGVKRQAEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWZ5</accession>
    <name>A8PWZ5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732003.1">
        <property type="nucleotide sequence ID" value="XM_001731951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWZ5"/>
    <dbReference type="STRING" id="425265.A8PWZ5"/>
    <dbReference type="GeneID" id="5856308"/>
    <dbReference type="KEGG" id="mgl:MGL_1271"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1271"/>
    <dbReference type="InParanoid" id="A8PWZ5"/>
    <dbReference type="OMA" id="WPEAEHF"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="395" mass="44194" checksum="7E310651DA880F9B" modified="2008-01-15" version="1">MLLPVGHGLCSSVYKAPMHGARIMEREGGVPNFVCIKQVDVDVQSAPHNVQREVALLQRTRHMNLALLLAVFTDSPDHFTTIYNVVMPLYPIHLPDILNSTCARPSSLSMAELAEQDEPWLHVLGFQTYSSFVLSSLRQLVEAVAHLHHEQIAHRDLKPSNIMFGIDGTLKLIDLGVAWEVGMHETPPFGRRPSEGSTDCAIISDVGSGAFRAPELLFAPKNGYNAFQADMWSLGTVLAGFFTSLDEEPVQSLGADFLPWERELFPDRPTHPELSRLRPRAYHRATLFDSSSGDITLACDIFKGSGDSQRDESDWPEAAHFQPPLHDFPFMHGPAKESLLDRLPTWAQLSEVDTSQASQFLKTFLPYWLPRLLELSAARRPSIDDLLEHLRHPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX11</accession>
    <name>A8PX11_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">60S ribosomal protein L41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732019.1">
        <property type="nucleotide sequence ID" value="XM_001731967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX11"/>
    <dbReference type="FunCoup" id="A8PX11">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX11"/>
    <dbReference type="GeneID" id="5856324"/>
    <dbReference type="KEGG" id="mgl:MGL_1287"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1287"/>
    <dbReference type="InParanoid" id="A8PX11"/>
    <dbReference type="OMA" id="DILVMTN"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="96" mass="10875" checksum="43A9C7230114080D" modified="2008-01-15" version="1">MRTSPTDTLTSPHKVTQYKAGKASEFAQGKRRYVRKQKGYGGQTKPVFQKKAKTTKKVVLRLECTVCKYRSHLALKRCKHFELGGEKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX47</accession>
    <name>A8PX47_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1323</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731140.1">
        <property type="nucleotide sequence ID" value="XM_001731088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX47"/>
    <dbReference type="FunCoup" id="A8PX47">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX47"/>
    <dbReference type="GeneID" id="5855441"/>
    <dbReference type="KEGG" id="mgl:MGL_1323"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1323"/>
    <dbReference type="InParanoid" id="A8PX47"/>
    <dbReference type="OMA" id="VWKIPRI"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725026" description="MHD domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="11">
        <location>
            <begin position="123"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="377" mass="43097" checksum="26E96D852519423C" modified="2008-01-15" version="1">MTIGGTTFLWVRHLDLCIVAAVMSNTNPTMVYEFLFCFISVCNSYIGELNEENVKKNFIFIYEVLDEMMDFGFPQNSDINALKMYVVSESLHGMVPTRQNVGRPTMDLPSEIGWRQPDIKYRKNQCFVDVLEMIHLTISSQGTVVRADVDGVIKMRALLSGMPECIMSLNSNVAPKSSIHNIPLSVQLSDCVFHPCIQFASSNGDPCLRFIPPDGEFELLRYRAKKNVRLPLRIYAVFERKNASTVQYQVVLRTNLDQQMKVSTVIVRIPTPHHATSVTCNVRMGKAKWDSNEHLIIWRIPKVQGMTESVFLADVFWKFQAGMQWQKPPIQVDFEVPSLTASGLAVRYLQITERSNYSAVKWVRYETQARNSFLVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX65</accession>
    <name>A8PX65_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731158.1">
        <property type="nucleotide sequence ID" value="XM_001731106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX65"/>
    <dbReference type="FunCoup" id="A8PX65">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX65"/>
    <dbReference type="GeneID" id="5855465"/>
    <dbReference type="KEGG" id="mgl:MGL_1341"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1341"/>
    <dbReference type="InParanoid" id="A8PX65"/>
    <dbReference type="OMA" id="EYPENDF"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="889"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="897"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1027" mass="112903" checksum="F35AFBFAA8E52941" modified="2008-01-15" version="1">MASEVLSSEIPEVTKVLLDNANTLLGPFWDSILSANSYGRTWPVPLHEHPLTKGSYTAKKDEDGSTDDVPMEVPEQQDHVISGRTDGPGFAVLAGYWAKVNMTLLERHPQEMLAFVKTIPYLVEGLTSHFETPAIVELLYRIIQCEDTVPDSGIVAWLAEQGLIPRVVSLLSPMVSPELHKAASEFLKTIISLSAPSPSSLNQVTVQDSFGGPGEMLLGAGGVNNLLVRELASEDMVNRIVSFMLDFSSNSRRSSATQETSRKNDLILHKLQEDSAVEEEEEEEDVWQFRQTMKDRQNRHFSIGRRLSSAGTGVRDSTATIRPSHVHRQSSIRRPISSQCLSSSFVNCAGVFIELIRKNNSDYFEQHLFHTLRNYLVIRQQELSGQQNQERLSQRTTDPSVDEKPELTLENLPLEDDADTEGLDEALDEVAQKMGIVHLGPLLRALAEKIPELQERVRCGLDSSGLITTSMGQIEPLTHTRYCIVELYAELLHCSNMALLNRPANSGPTYSPSGSLLGGLEGLHALARTLQGEDDLEQDQSSMSASAEWEADRDENERHLSESSASSFKENGGSSSAEITDSSGSDHAEDGSDAESIASALSSMSLADMISQFTRRRPPAQESDVQIVGNYLKTQFLSFQVIPTLLELLLAFPWNNFLHNVAYDILQQLFNGDMDVAINRKLTISAFKDAHLIETILEGARRNRASSEGPRRIRLGYMGHLNLIAEEIVKLMERYPLEIGNYVQDHFTTEWEKFLNEDLSDYRAKESAPLAGGRPSGNHSGVQNWSNLDSDNWYSSNDNNVSFGHYLSSQMRSGAGDEESEGNAVTFLSQTDSMLDPATQDAVEWGPFADSHSAFEFTSTASIDPQQPGRQENLTPADWAAEFRRGTMDDIPAESAVDNDSDSDDMGDAPDASGSGTDSDDNNDDDSPFVDLHKPGALRKCTQNMDAAHPERVAGHGDLTGDQHWPAAHAAHHVRTFSGGGRDNAAALAAEQLHEAVEPTEEGLLRRTLSDGTTVTAPLDDAELAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX95</accession>
    <name>A8PX95_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arf3-interacting protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731188.1">
        <property type="nucleotide sequence ID" value="XM_001731136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX95"/>
    <dbReference type="FunCoup" id="A8PX95">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX95"/>
    <dbReference type="GeneID" id="5855495"/>
    <dbReference type="KEGG" id="mgl:MGL_1371"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1371"/>
    <dbReference type="InParanoid" id="A8PX95"/>
    <dbReference type="OMA" id="WDVLCDC"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arf3-interacting protein 1 N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="661" mass="73552" checksum="428AF51D018047A1" modified="2008-01-15" version="1">MTSESTSSTSLSYFASESLCQFCVLATFHADQGPVLEHSVPVHTGLDEHMLAEQMIPDGLHKRDGDWTLLIRRVSELSLPHVPERPAHVVTKSPHTEATDAGDCIYILSSARTIHTADARRGAKLFALAVGTMHPHVSLLKPVLVLALDAYVTNPSPSILVQLHESLNSLPISTLSCVSYSEKVRMRSDPILHAMYHSSGNSTRMVASPLSFSKQDAPCTSLTSVATHMQLYSALSASDVTLPTMRESRRHSSASTSSMHSRRSFVRSRYLISKPQHMCGPSHYYITSISFGRVCIPISIPLYLFPEEVGEYSLSRLFSTFGFVKPSSSHGLQHKQHHRSPLLQHHHHQQLLLLHPHLHSNGVYTHPVTLLFNALITHKRVLFVAYHSPATVVVEHVLAACALVSGCGAVLRGFVASSIPYVTLASLDTLRSMRGFIAGTTHPRIEELGCWDVLCDCESGQIIVSAATPAPPPFLPFDAQNNRHAKRTLRSMMRSMPEWMLGDERADAPDVLFMHQLMEAVKQHASESFLRHWCQLYVRQFVALSMQHEQAFYGVTLCHMLPDLRLTSQTARDMYSLRCHALRIEAWRMTPSYRCFLRDIANMNGHYKHISATFCLSPCSSQADATPSDGAYEAKRSQGSSTHEGHITNNVRRSSWDISGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXC8</accession>
    <name>A8PXC8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1404</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731221.1">
        <property type="nucleotide sequence ID" value="XM_001731169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXC8"/>
    <dbReference type="FunCoup" id="A8PXC8">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXC8"/>
    <dbReference type="GeneID" id="5855528"/>
    <dbReference type="KEGG" id="mgl:MGL_1404"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1404"/>
    <dbReference type="InParanoid" id="A8PXC8"/>
    <dbReference type="OMA" id="LTKYGCG"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="135"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="528" mass="58664" checksum="AA951D6CA8DE7B8F" modified="2008-01-15" version="1">MTGSDSIHQDPYGGIVQWMVWLVNSIPGRDIVVRYIASSYQHDPVRSLLELILFIFALRTILQNRTRARGNSHFIDFSKKEIDYLVKEFEPEPLCSPLTAEQQEELDGIPEVCGHASARPLVKAPWMTGTLPRRVLNLASFNFTGMLEAPEIEAQARTILREYGVGSCSPPGFYGTSDMHIKLESRVATFFRKDSCIVYSQGFSTTSSVIPAFCKRGDVIVADEGVAFSIQKGLQLSRSHIHWYKHNDMKSLESVLMHLNEEQESSRRPLTRRFIVTEALFERDGTITHLPQIVELKKKYKFRMVLDESYSAGILGNTGRGLTELQNVDPDDVDIIVGNLAIAFSTAGGFCASTKEIVKHQRINGLSFVFSAAMPVMMANGSTVAMDLLDGDLGVFERLRENTSILRNALDPISAIAITSSPESPLQHVQLRPSEDDTNLAVLYSDPKAHASWMASQQEVLKKIERLALNQGVWISRNPHIPSIRAELDQGPWARPSLRIIATSALSPAEMRQAADIVRASIVSVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXE3</accession>
    <name>A8PXE3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sorting nexin/Vps5-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731236.1">
        <property type="nucleotide sequence ID" value="XM_001731184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXE3"/>
    <dbReference type="STRING" id="425265.A8PXE3"/>
    <dbReference type="GeneID" id="5855543"/>
    <dbReference type="KEGG" id="mgl:MGL_1419"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1419"/>
    <dbReference type="InParanoid" id="A8PXE3"/>
    <dbReference type="OMA" id="CIENTEF"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07596">
        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="2">
        <location>
            <begin position="130"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="527" mass="59071" checksum="9FDF43926F4BDCDA" modified="2008-01-15" version="1">MLHMPHVEHPQEDMYELHELRILLQRWFSRISEESALRMHRETMRFIEADYSYEPLPPDELAPSGLVKQYRKMDSQIKSLQHVLDGSLFSQDEDASTRTRRSWLFRRPAIPAHRESPAALVPTMLAGPSSMTVLDPDKRLSMARGEVTRLEKQLGDVVSACTSVAKARQDVDRAMEHVARKLPALAMLEETRPASMQGRLPHTLKSAHSMMNHVAQLSDQMMRADQVTLGDALEYEELNLRIARQTLQERMAIVVERTLAKRVVSNKQHDAEHYKFARHQRPDRLESAKEEVQEAQQHMELLERYLSQVSESLNESLQRHSIHTHHDLQCTMQLHARTSRSLEKRIADMLALFDSECSATAAEAQRIALQAANAPRKITAAQAAAARITGHAIDEPADTDRRTAIVTPVEEGPPVGSMASSFENSATTTESTMAAGATDQPRTDDMVAPDLAGTPNVWISSSPSLEDRLTCIREPEPDSEPETKPEPEPTVAPDSFFPSMLSRRGRENGPWTRLSASEAAKSLGGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXI0</accession>
    <name>A8PXI0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731268.1">
        <property type="nucleotide sequence ID" value="XM_001731216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXI0"/>
    <dbReference type="FunCoup" id="A8PXI0">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXI0"/>
    <dbReference type="GeneID" id="5855575"/>
    <dbReference type="KEGG" id="mgl:MGL_1451"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1451"/>
    <dbReference type="InParanoid" id="A8PXI0"/>
    <dbReference type="OMA" id="RFWTSQP"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="6">
        <location>
            <begin position="264"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="265"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="864"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="4">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1065" mass="121614" checksum="56943EF015F83B3C" modified="2008-01-15" version="1">MSSQCTSHALGARAPRNEHGFRPGSIVRVACEHFVTYDAVEFRPGPYLNMIIGPNGTGKSTVVCAIALGLGWKPSVLGRAKDVASYVKLGHTQGWVEIELQGYPPPQRNVTIKRILFRESNTSDWILDGVAASAREVHQAVSQFNIEVGNLCAFLPQDRVADFAAMTPQRLLQDTEHAAGHAQLSDWHMQLIECGRQKSELQSRLEQEQREHDYLEERNTVLERDVRRYEERIALEKRVCALEVRIAFAEFHDSKSRYHAAHAKREEAKRALERIFQSIEPLEQELERAQEKLDKMELVSSSHRREADDASSALRRYSTARERLDAEMAALSEQEKRLEAQAAERRELMQQMRSRIADLERAIEARATPEPLAPYEQRLRAVKAEHRMASEDLRDMDSQSADLYTQQQRLASQMAEARVSLERLHTERHQRLQLLARADRDTFEAVQWLQHHQDMFERTVYEPVLIAVHINRPEAARAIETCLSWPIQRTFVCQTRADYDLFTHELIDKRKWRLNVVELEAARSLASYTPPIPKADLLSLGFDAYALDCIDAPEEVLKYLCSAASLHAIPLDLRGRVRPQDMESRQAVRRYIVADTIFTTTTSSYGRRLPQTMSRVLKPLRSFAHTSDQQERQNAAAVLRHLEEQHTACQASIQHAKSMREQHAARVDSLSQQRSEAASAYQLVADAHKESQRLELKLQSQRDRLAHEEAQPSLAVQRREIHATRQKYAVELSKLAERSFRCFEAIVRSNAASDETLLASLHACTDVQTCRASLREQQTRIEESEQAVRAAVAEFTTIKTRTLELKRCAEQKLQEAGPDVQSLVQTSLEDGRHESVEHLHTLLDRARAQLDVPWGVGPGVMETFRARKDKMAELKRTIEQARSEQNRLVALIEQVEGMWLPELEALIRAVNERFSAAFARLGCAGEVHLARDDNYEKWGIDILVKFRDTERLQLLTNQRQSGGERSLSTILYLLSLTELSRTPFSLVDEINQGMDPRAERAVHDQMVAMTCQPQAGQYFLITPKLLPGLLYHELMKVLIINNGEWLPERLSCTLSEILLTHIHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXM1</accession>
    <name>A8PXM1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731296.1">
        <property type="nucleotide sequence ID" value="XM_001731244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXM1"/>
    <dbReference type="FunCoup" id="A8PXM1">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXM1"/>
    <dbReference type="MEROPS" id="T01.P02"/>
    <dbReference type="GeneID" id="5855603"/>
    <dbReference type="KEGG" id="mgl:MGL_1479"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1479"/>
    <dbReference type="InParanoid" id="A8PXM1"/>
    <dbReference type="OMA" id="CSEQLYG"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="201" mass="22536" checksum="AC2897BD02DD8051" modified="2008-01-15" version="1">MEYNGGSVIAMTGKNCVAIASDLRLGNQALLLSTQFDKVFRMTDRTYVGLPGLATDVATLREKFRYRLNMYRMKEDRDIEPETFAKLMSSTLYERRFGPYFIEPVVAGMNSNNEPFIAASDLIGCLNFAKDFVVSGTASDRLFGMAEGLWEPDLEPEDLFETISQTMLGGIERDALSGMGVIVRIITPDKVIERTLKCRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY04</accession>
    <name>A8PY04_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731381.1">
        <property type="nucleotide sequence ID" value="XM_001731329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY04"/>
    <dbReference type="STRING" id="425265.A8PY04"/>
    <dbReference type="GeneID" id="5855688"/>
    <dbReference type="KEGG" id="mgl:MGL_1564"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1564"/>
    <dbReference type="InParanoid" id="A8PY04"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="88" mass="10064" checksum="8A5F6E29F1CF809F" modified="2008-01-15" version="1">MDLLDAEQQEALPFSLDYYTDAQDLNYMADYLHETQPRVARMYEVLGDIVQEYGLVSFETLAVEEKASMLHLVEVLDRAIGYVARDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY14</accession>
    <name>A8PY14_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731387.1">
        <property type="nucleotide sequence ID" value="XM_001731335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY14"/>
    <dbReference type="FunCoup" id="A8PY14">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY14"/>
    <dbReference type="GeneID" id="5855694"/>
    <dbReference type="KEGG" id="mgl:MGL_1570"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1570"/>
    <dbReference type="InParanoid" id="A8PY14"/>
    <dbReference type="OMA" id="WGPNMKP"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22450">
        <property type="entry name" value="KH-I_ScSCP160_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="123"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="199"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="347"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="428"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="513"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="594"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="670"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="745"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="822"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="911"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="974" mass="105467" checksum="F016DA2B6C6D8EC3" modified="2008-01-15" version="1">MFIIKGPTEAAVLEAKRELTLQLAERVTLTMLVPASLRAFVIGAGGKNIRAITDETGVRIHIPPRSTDESAAKEAAMSSSDADADALGDPLLGEQIEITIDGDTFNAHDAQARIQDIVAERTSKITQRLTHVEPAWFPFIHGPRGVRAAQLMSQEGRGEVSVKVPPPQREGVIVVSGERELVPQVVRAIEAQVEDMRRSFRTLSFNISKRQHAFLVGDSAADILASTQCSVELPPVHDSSEAVMIRGPQTQLPHALTAAMDRVNAVAVETMDMRSMHPDADAAHLKRLVQWLITYAPREENVQVFMPRSSAIDNAHAAALVEVVSEDAAAARRIAQTIEHQLRSLDTSSVRMLEIDPLAHGFVIGKKGQHIKAYEARGVDVMLPPEKSGRDDVLLVFRPGQTVSESERVAELDRVCAELVATAAQAADLRTEHLRVPSKYHGAILGHDRTVLNAIIGDDRLLVSLGGRMPVKQVAEPLTEDSIVVRGASEAVARAVAQIQRIAKDAEEDSIVNGFVDELSVPGKFVPHLIGRGGAGITKLREDLGVKLDIAEPDEGASSSAARTKPVPIKIVGRKECVAEAKARLSAQVERLADEVTQTIQVPQDMHGALIGQGGKYVTRLQDKYDVRINFPHGHDARLKPDEVSIRGGRKGVAEARTELLELLEYEKERNNTKVLVLPTRAIARVLGRAGATINQIRLESGADIDVDPQSDAKKPTTMLQLRGSNEAVAAAEAMIQAIVEEVESEAELHVTVPSAFHRHMIGPGGQRLHELIERAGGPSDPKSHTQMVRFPRTNSDQVLVRAPKDLAAKIAAVLESEAQFLASRVVYGAPAPVRLHNQLMARGGRKYTPWQTDLGVQLIMPTWREYAQLGAPVNAADLENAEPATVIKVLGPEEAVRKVVDEIAAIVAANPSSSHSRRQRTRAPASTSSNTHTHTHTHTHAHTHNNTNTNTDSAATANTTAAALNARIDDDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY45</accession>
    <name>A8PY45_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731405.1">
        <property type="nucleotide sequence ID" value="XM_001731353.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY45"/>
    <dbReference type="GeneID" id="5855712"/>
    <dbReference type="KEGG" id="mgl:MGL_1588"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1588"/>
    <dbReference type="InParanoid" id="A8PY45"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="425"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="984"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1572" mass="171113" checksum="8B5424AA5E9C5D9B" modified="2008-01-15" version="1">MIQIVGSGTIVTTDEYEHMIDVSLPRLLLRQLEEPCSERPFTYEPSLRVPAYILFTSGSTGKPKGVQISHRALAAAIKSWKIMLPYTQQSRLLQLASPGFDVSLFELCLPLSLGFAMATAPKDILLTDLEAAFRALRITMADLPAALAALVHPEHLPPMEWLMSGGDMVDERVVREWGTPPQKLINAYGPTEGTIGNTLGHVDANTRRSVVGKVYPATTLYICRGNELAYTGAVGEIVVGGPQVADGYVGAPELTAQKFPTLTLGTRSQRVYRTGDRGRLLHNGVVECLGRMERGQVKVNGQRVELDEIAHELATEFGISDACVQYLQHPSHPSKQLVAFLALTSVSQSTAAALDVRTDPEALSRSQQCLRGAQKRLAPYMVPAHTLVLTTPLPLTPNNKVDVKRLANLYMDMDPKRMRDAKSSRPLTQTELTLLRILTEFTHMAPADIDRDASFYTLGIDSLSAIRLVKLMRLRGMKLTVSELLAHATPSRVAAILDEMPAKNEEDFAAYKDILQEAALPSNLSSRHVLPCTPLQAGMLAQTAASFGGLYTHIHAFSLDVSAEAIVSAWARIVRNNAILRTTFEPYDCQQVPWVQVVHDDWPLIAPTLVQHAPSTPLDVVLRAAQAACDPSTRPHVLHMVPTSENSMLAVWAMHHALYDAHTLDVLFDDVDAVLCGEQAPERLPFESVVPHLCAGSPHVPYWLGTLRGYVPRTLSPYRRDMAAAIPGSAAMLSSSASMSREARTSTFDTQLASSIVEDACRQCGVSVHTLATLAFAFLLAECMQTTDVCFGQVFSLRSDVHDAVDVLGPMLNTIPTRVKLQASSFDAQLESLQRTVDAARPHRHAPLRSIAVEHQRTHNSTAPLVEALLDVQQHAANDQHPIHIRRIPLDMEDQVQYALNVEFIQTPTTIRLVATARTSFCGHSSNLQTLLRRMSDILQTIVSNPRGTLAVASLDSEQPTIQPSNTLSPSPASAATALEDIPPDILLQVRELTADVACVPLSDVLADTPLLLLGLDSIVAIQIIARARVRNLSLQMGDLAAGTPRGIAAAWCERMKHESETSSARMAPLSSPIPLSFASNTPCTQAQVATATAAAAAAEAHCPMQDVVAVRPLSAGQMMHMASLVHSQHREGVFFHAYRARGQLDSKRFAHAWEELQKRHEVLRSIFVCVHDCEPAQVVLKRTQGMHMHRVSRSDDAMPCVFAHHRTWPADEPWASADLVRIDGEDSKNDVVVLSLFHAMYDAWSLPVLVDDLVSLYQGEGTPASQATELAPASMANLLTAASQSKDVSAIQHHWASYASAPPCIAAQQSDIDGAIDKPSATKAMTSTVAAPTTASFTFVHQRDIVHCVQRLRMHLASHQISLPSVLVAAWASVLHDVVHTSVPVLGLYQAARSLATLDLSRSAIPCVNMLPIAVPWHPSLLSMAHYVASALVERVPFEQVSLEDVHRALEKVAPGPTTFPHFDTMLNVLIQPSASAGAGGDVGSEILLEPMQSPICEEHLRSPPRICERTSFDAWPGAGHYPTAGIAVDAYVDDEDNLSFALRCPAHVLSEQKAKALLDKFAAYVQTVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYJ5</accession>
    <name>A8PYJ5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="7" type="ORF">MGL_1674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731491.1">
        <property type="nucleotide sequence ID" value="XM_001731439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYJ5"/>
    <dbReference type="FunCoup" id="A8PYJ5">
        <property type="interactions" value="591"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYJ5"/>
    <dbReference type="GeneID" id="5855798"/>
    <dbReference type="KEGG" id="mgl:MGL_1674"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1674"/>
    <dbReference type="InParanoid" id="A8PYJ5"/>
    <dbReference type="OMA" id="FRCGLIK"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="647"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="856"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="856"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="907" mass="102862" checksum="3F7223EB1B707E50" modified="2008-01-15" version="1">MSSRFFRAISDSESESSEEEELLSDNEQKEVKPSTKSKAGRGSDDDDSEEDDSEEDESEEDEDEEDEEEEAPQQARKPMSRFMRDVDESESESEEEAPKVIKSAKDKRLDEFQNSVHSIENAQRIDDWMTISKEFDTLLRLCDRQRTLNESIPSSFVKCLASLETFLAETLANKEATKKMKAPNAKSMNGMKSKLKKVVKDNEAAIQQYREDPEGYDAKVQAAQSTPAVPEMPSLKPKKTDTVTSAAPVVAPSGEAAGGAGDDFQTVGPGGKVVMTADALFKGLAAVLEARGRKSTDRGEQISTLMKLYEGAQTPYQRIRVLLTLVAARFDYSTLASTHMPIDMWKQARDELTTLIKLLLENLSYVVLEETDDYDDQVERKPNENGEGEFVPVRGSVVSFIDRLEDEFTKSLQNTDPHATEYVERLCDEKLLYQTIVLGQGYFETVLAQQLPEKMALMVSEPLRRCVMRRLEHIYSKQDVIILALETANHEAQPDAPSSRITPSFEEVRAREDGPMHLVHALCVYLYQRIDDTSERQRTRAILCHVYHHALHADYYVARDRFLMSHLQESIHLADAETQILYNRVLVQLGLCAFRVGLIRECHTALQEIFATGRVKELLAQGVSKGNMYNAVSTEQEKFDRQRQLPFHMHINLELLECVYLVASMLLEVPNMAYAGTDMELRKKVISRPFRRMLDYTDRLVFTGPPENTRDHIMQASKALQNGEWKTCVELIQSIKIWKLLPQKDVILERLARHIQENGLRTYLFNFASHYDAISLEHLATTFNLPETTVRSIISRMIWHDELAASLDPMHGVIVFRRMELNRVQQLSLALADRANAMLEQNEWLLDSKLDDHRSIHSGHGGDRQHAGDATGDHDAGLGRRDGRRKGGRSRGGPRVQLQAQALSQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYJ7</accession>
    <name>A8PYJ7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731492.1">
        <property type="nucleotide sequence ID" value="XM_001731440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYJ7"/>
    <dbReference type="FunCoup" id="A8PYJ7">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYJ7"/>
    <dbReference type="GeneID" id="5855799"/>
    <dbReference type="KEGG" id="mgl:MGL_1675"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1675"/>
    <dbReference type="InParanoid" id="A8PYJ7"/>
    <dbReference type="OMA" id="GMKIWAI"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="544"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="638" mass="70220" checksum="2EBC053BF272A9D9" modified="2008-01-15" version="1">MRGASPKPEASIIATPPRKRAVPLDGIHARNVPEYSREKRVKTPRTNVLQGSAHGSNDAYANTGSLPHTRSTTTRIDRSARVSHEERYQRERQKVQSQRQWKVAFGRAFPKFVFYLDGMDEAQRRTCSSQIVQLGATVEDFFSRSVTHVVTTRPIPVARDTVKEISQDHSSCNHKQTGSSERGQGNEDTYGNGGDKSAHDVGGACTHSGRPGISPPRILMPVPLVGVPLHSDRNPLDESTPSLPASDLLSKAQHFGMKIWRSEKLDNILSLLLADDAPPGAGNAAGRQNLSDMLLQEKLHGTTERDPLAIRSDVHYFGKNSYHVLVTDATGEHRPILMQEYDRHAHEAAGKHAPWPELHGDVEGRGLFVYVDPKERKRLAQHAPMPNPSSRSLRRAASLHLAHVRNSPAGPGTPNLMASDNSMALASTVASTTSMSLTSQQTTMQSAPTSADKRVLELHRRLHTPAERSNESHGVIIQRMLQGMLDGRASTQNGQGGQIGHCSGFGEAISLGDTSTGAPMATLHRSRSLGSMTRKCVSPSPRRREKKPGHCENCRCRFDDFYEHTRSRRHRNFALDESNFVNIDELLQRVQREPLPMTSSWADYAGTPPSATVYHDEECGGIVTAETPSSYPSFVCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ82</accession>
    <name>A8PZ82_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730897.1">
        <property type="nucleotide sequence ID" value="XM_001730845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ82"/>
    <dbReference type="STRING" id="425265.A8PZ82"/>
    <dbReference type="GeneID" id="5855204"/>
    <dbReference type="KEGG" id="mgl:MGL_1896"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1896"/>
    <dbReference type="InParanoid" id="A8PZ82"/>
    <dbReference type="OMA" id="SASHPCA"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF444">
        <property type="entry name" value="HECT DOMAIN CONTAINING UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="386"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="653" mass="70332" checksum="00B9D86EA4D92300" modified="2008-01-15" version="1">MNARASQWRRTGRVPRFDGDSRLVLDGREQCEEGANDQGYAQVIFRDKSMGSGPMANGGAWACMFHAAQTGSIASRAISHGINGAAASSTTALLSVHGTSSSLSKQRPQTFASDASTSADGHDKQVAYKKCDSLDGPPSSDVIDGANKAKMPCIRTLPPLYLQLFDSSLTPEERAQVSSSLSTHLMELGTSRDASIADVLAALEVSSHVSRACTEALATHVDCSVAPYVQAYDLDRLACIVDSLTGALSWHVSAHGARGTEVPISLVHALTCVRDAALHRSTKLSATRFHVAATELPSIVHSYAVWLKGGSDRNLCDKPWLLTLGAKAQILAWEAQCAMRQASNEAWISPTSSTSIMSSPTSGLWRVSVSRASIVNDSLDAFESASFAQLHQPLHVLFRDELAQDAGGLKKEWLQILCDQLQQHLPWMDLGSSEPSMRGLVFFSASCNEEELQRAHLLGMAMGLALYHQVTVPLRLAPAVYTILLALSRGETAPCDLATLAQVKPDLAVGLERLLQEDPANVEQMHLTWQVDDAAVGHVDEGRERTSDLCVGGSARLVTAADREAYVRTFVLFTRCSRRCKGPLEALVHGFARIGVPGDWALSAVAPCPARARELFCAGEMNGPLIRTRCAPIQSMSAFLNATRLMLSVCMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZU3</accession>
    <name>A8PZU3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730951.1">
        <property type="nucleotide sequence ID" value="XM_001730899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZU3"/>
    <dbReference type="STRING" id="425265.A8PZU3"/>
    <dbReference type="GeneID" id="5855258"/>
    <dbReference type="KEGG" id="mgl:MGL_1950"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1950"/>
    <dbReference type="InParanoid" id="A8PZU3"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="4">
        <location>
            <begin position="50"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="215" mass="23336" checksum="3ECB3BE5858742E2" modified="2008-01-15" version="1">MYRATLKAPVPLYNAEEQQIAETGPPIICAPATPTCKDDQRAYNLVSWNVLSDTVTLPTSTMRACMASAVCGDEGYKTDEPTKLLERTVAQLAGKEAALFCASGTQANQLAIHAHLARCTLPSAVICDFRAHIHACEMGGIAYHSRGTTVPLMPRNQHHLTLKDIQTHCESHGSTYATRVQVISLENTLQGMIFPHDEVQRIATRSCRCGASSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZZ7</accession>
    <name>A8PZZ7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730966.1">
        <property type="nucleotide sequence ID" value="XM_001730914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZZ7"/>
    <dbReference type="FunCoup" id="A8PZZ7">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZZ7"/>
    <dbReference type="GeneID" id="5855273"/>
    <dbReference type="KEGG" id="mgl:MGL_1965"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1965"/>
    <dbReference type="InParanoid" id="A8PZZ7"/>
    <dbReference type="OMA" id="CEPFKVE"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="324" mass="36264" checksum="9B627FAF18EC18EA" modified="2008-01-15" version="1">MPTGALTKTSLPLPLIARGKVRDVYDSGLNSGEYKGAMLIVATDRISAFDVVLENGIPDKGRILHGLSEFWFRQLTPKIIRSHLLGTQFDEFPQPLKEALANVRDQVEGRCMLVRRAKVLPVEAIVRGYITGSGWSEYKRSGTVHGIKLPEGLKECEQIPNGPLFTPSTKAEQGEHDENIHPDKVAELIGPELAESVATKAKQLYAEAENFAKSRGIILADTKFEFGLVRNIVNGKEQDELILVDEMLTPDSSRFWSADKYEMGRSQESFDKQYVRDWMKANGLDKAAQTFTPVTLPDEIVEQTAAKYREAYKMITGRQFETTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q041</accession>
    <name>A8Q041_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">REM-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730980.1">
        <property type="nucleotide sequence ID" value="XM_001730928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q041"/>
    <dbReference type="FunCoup" id="A8Q041">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q041"/>
    <dbReference type="GeneID" id="5855287"/>
    <dbReference type="KEGG" id="mgl:MGL_1979"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1979"/>
    <dbReference type="InParanoid" id="A8Q041"/>
    <dbReference type="OMA" id="PEWYQTF"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="211"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="606"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="984"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1182" mass="129853" checksum="3068EFE480850139" modified="2008-01-15" version="1">MSNIQFADVSARLKLESRIRDGARNMLQILDASTSNDALRGQVERELAVAEEQVQTLNTRRKGIENTLNSAVASSSRFRRPRAIRAVHGLEDLNTHAVIPSLSPDPFALPESQAFRLPASVLSGPPSSAPSITSTSAYIDEIACSACTVEALTRILQKLLSTRIEAINLRDPTSSASVAQPKSRDSPMASDHELCHLFLFLSSLYQQLPDLRLETDTQSLTQCALLGISLGALSMVRAYAMRLLRYVLSAPLLPDLATHTNALPLLLCRALTQEASCVFEREQSLKLVRACMHYTRLGSQHAHTLLTVGVVRVLAAIAVEPDDPLCSASIETLAELALLDTPLVARSSAMAPLWRAVCETPADVAVPLVTSMLILLDRPTTRRHISAGTDLASVLAGFTSVPSAAESSSQLSTTQQVVSHLLLSWQGLFYLCMCDMGALRSLVASLYVEDQTIRRHVLAALLPLFRTVDATVSHSPMLHVRVSYVAFVLMLLLDAGLWDALLMIMQHTPRHDNLASELLDRILTFSRDMMPQEGASLHACAALVHRICVPNEQKPELMVGASHVLDAVGRSEAVHTFSSRANQNQAQPTSSHEVSPTYAQGMYMTLDDAHFRTMLRDSMVITAREHTLWNQTVILELLDHALWDPKRFDEALNGFKFIRRLLAFFRPAHMRYASMKKHDVAHRWTAVGVSLCRVLLYHADGVRVLVEEHLLSDLRDSFEQLGQRASETLFSLHHLQHNIVTGYFEMLQVLSASAVGLELLTHARLFTPLMCLCENEDDASVQVVCSLLAVLDVSAHALPRVFLERALSDGPDRVREAATKRVGHVLCLDDEPQPWAMSLLLTQLYDPSASVRTAATNEMERACAHPAMAQCAMQQGPPVDLLATHTTIALLGLADSRGFQLMHRAGLLSPLAQAWYARDHIAYVAQAERVMALDSATPFLPPHLYGQLAKTPAGCVYLAELHVLPEWSTVLAGHALESFDSAMLEKVKAALWACGHVGASDLGMSMLQLHDLVDLVFQTAKSPVVSIRGTFFFVCGLWAHSERGRCVLTDRGWDMSATAHVCIPRDFRAFVYLPGSGTTGVNQGLSSRLTPPKDEQEAYATGLLANLGNGVVAGSARRALLRHRQQHPRVYRQVSLLGCALHMMDHFAFRLAARRSIWAILVECPLNSRHDPRASAMGAQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0A9</accession>
    <name>A8Q0A9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731007.1">
        <property type="nucleotide sequence ID" value="XM_001730955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0A9"/>
    <dbReference type="STRING" id="425265.A8Q0A9"/>
    <dbReference type="GeneID" id="5855314"/>
    <dbReference type="KEGG" id="mgl:MGL_2006"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2006"/>
    <dbReference type="InParanoid" id="A8Q0A9"/>
    <dbReference type="OMA" id="FRFIQRP"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="506" mass="54518" checksum="2E7ECD461432C55A" modified="2008-01-15" version="1">MSYDKTTVLLVRNLPQSVEDYIEVRIAIMGNVDAGKSTLLGVLTKGGLDDGRGRARVDLFRHKHEIESGRTSSIGSEVMGFQADGKPVVEVQTLDEPIRKIACGEVCAHSAKVISFIDLAGHERYLKTTVFGMTSGLPDYVILMVGANAGLVGMSKEHLGIALALGIPVAVVVTKVDMCPPQVLETTMQQLNKVLQSPGCRKTCILINSAAQAIDVALQLPVKRICPIFQISNVTGERLDLLRLFLNLLPSSQAKFAPLRSAPVEMPINDVFSVPFVGTVVSGVLKSGVVKTGDSLLLGPDSLGQFTVTSVRSIHRKRINVECASAGQSVCFALKRVRRNQVRKGMLLISQTSTPPVACQEFEAEVLCLYHSTTLSVGSCIVLHASSVRQTVKIMAINKLDAAKQKQPQSFSLQAADDAKPVLRMGDRARVQLRFMSKTEYLTPGTKLIAREGKTKLVGIVRTIGNQDVLASGAGPRYEDHKSSTWRDNGNGSKHLVATPQLSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0C4</accession>
    <name>A8Q0C4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2012</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731013.1">
        <property type="nucleotide sequence ID" value="XM_001730961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0C4"/>
    <dbReference type="STRING" id="425265.A8Q0C4"/>
    <dbReference type="GeneID" id="5855320"/>
    <dbReference type="KEGG" id="mgl:MGL_2012"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2012"/>
    <dbReference type="InParanoid" id="A8Q0C4"/>
    <dbReference type="OMA" id="EEDDQYQ"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="13">
        <location>
            <begin position="91"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="363"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="486"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="586" mass="66869" checksum="85B5B654ADD32156" modified="2008-01-15" version="1">MVKAESNSSNRPLAGGRILRSRARTATLDESVVNKIKEHQKELVKQKQDEGLKRFAGEGGASRESNEQIFKKFESYRRESQLPSKVEDLKIMVDHRAQSIILPINQFAVPFHIKTLKNVSKSDEGEFTYLRINFVTPGQLSGKKEDVPFDDPNATFIRNVSYRSTNTRHFDDLYNEITEMRRIAAKREAEQKEMADVVEQDELILNKHRPLSLPEVFPRPALEGKRVPGNLTIHQNGVRFVSPLRQDQKIDVPFSNVKHLFYQPCDKELIVLIHFHLKSPVIVGKRKTRDIQFYREASEVQFDETGNRKRRYRTGDEDEIELEQEERRRRHMLNKEFKHFAHRIADASEGRVQVDIPYRDLGFNGVPSRASVLLQPTTDCLVHLTDPPFLVVTLSEIEIVHLERVQYGLSSFDMVFVFSDFSRAPLHISSVPTSSLDDVKQWLDSVDVCVTEGAVNLNWGAIMKTINEDPYAFFQEGGWGFLQADASDASDLSDSESESEFDSDLDDGDQESTEYSDSGSDFGESEDSGSEPNEDSEDEGEDWDDLEAKAARDDQKKRRERGDMSGSDDDDVKPRPKKSKGGFNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1G2</accession>
    <name>A8Q1G2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730784.1">
        <property type="nucleotide sequence ID" value="XM_001730732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1G2"/>
    <dbReference type="STRING" id="425265.A8Q1G2"/>
    <dbReference type="GeneID" id="5855091"/>
    <dbReference type="KEGG" id="mgl:MGL_1783"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1783"/>
    <dbReference type="InParanoid" id="A8Q1G2"/>
    <dbReference type="OMA" id="HRYPGWT"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="533" mass="58797" checksum="6B15C937A3361946" modified="2008-01-15" version="1">MSMPTGLRVQLASFNANQMFDGTGVPDMREWLVPTVNESRRSGYMTTDEGRELTAMSLGPREAPDIYAVAFQEFAPLHKALSGTVSQARTQADLAIRRSVRHHQSIVRDDKMYDPLELGGGPENYAKIADINHAGLVLFVYARERAPQRAHGTQISAAHRVKEVRASFVGTGLGMVMGNKGAVGARVVLASAVPGGRDEVLTFVGAHLAAHDHNVARRNAEWRSICERMVFDLMSVQLLPVLQEPPSLAGDDGDEKHGGNGYGNGDGNGHGGGRGVHVASVPTMRGCAPEMQSNADAADDNEYSLYDTHHLFVMGDLNYRVATGVDGVSPRGQRTVPGKYPPITKSDVHEVARSFQSDRWASLVPYDQLLLERYAPTPRTLHGLHVPDMAQYGIPPTYKYKARGEMEQLSKKRLPGWPDRLLWGTSDASYAASGTLRCELYRSLMRYTSSDHKPITAIVQLPHHLHPLSDFLPVPYALHPNWRTWRLVGVVLDRLVGYAWSCLLLLGHGHLYVAVAELLLLTTVGWYYVQGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1Q4</accession>
    <name>A8Q1Q4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Initiator tRNA phosphoribosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730824.1">
        <property type="nucleotide sequence ID" value="XM_001730772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1Q4"/>
    <dbReference type="FunCoup" id="A8Q1Q4">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1Q4"/>
    <dbReference type="GeneID" id="5855131"/>
    <dbReference type="KEGG" id="mgl:MGL_1823"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1823"/>
    <dbReference type="InParanoid" id="A8Q1Q4"/>
    <dbReference type="OMA" id="PVFWANQ"/>
    <dbReference type="OrthoDB" id="45256at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="2">
        <location>
            <begin position="297"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="48372" checksum="73F8E9843F2161CE" modified="2008-01-15" version="1">MHQWDFSMKRANLHLIPLIQPHHQQQPQDDEASVDQAGSGATTELTGCVLIDSTRRGKRYPDALSKTVPIWCAVLNRASHRTFGTPSDPPPLQIPTDTVSLSEAAQIEARLDMWVHKFCASDLAVPCLEKPLCPVFVHAPHIPTLPTCAMQHHIVLVSVSPSETPKAFHTMHASYVQGAGDDHEAWAHGLTPALFWRHHRELLAPHLQREDRVKLVHKLVREERGRSGQVPWLATDNSATRIDGTCLFIAARPLAHSFSHHERSRYAFIVHCSQSEREPSTTPATQQQPCTSETPPVLRLGIDASKRGLGSFSRALPLVVDAVTDALIWETRNKEHPRGVLVCCSDGCQLSGAVAVAILAASYDQHRQFLGTGTDAHQKLTKHRKRISKDDTQRRLQWITGSVHSVSQTSPSRAHLQRVNAYLMGPLRQVRLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1Z2</accession>
    <name>A8Q1Z2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_1861</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730862.1">
        <property type="nucleotide sequence ID" value="XM_001730810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1Z2"/>
    <dbReference type="FunCoup" id="A8Q1Z2">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1Z2"/>
    <dbReference type="GeneID" id="5855169"/>
    <dbReference type="KEGG" id="mgl:MGL_1861"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1861"/>
    <dbReference type="InParanoid" id="A8Q1Z2"/>
    <dbReference type="OMA" id="CDLILIM"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000171">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="196"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP43648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="266" mass="28902" checksum="0DC7627AED382672" modified="2008-01-15" version="1">MPSVKVAPSLLASDLGNLSYECNRMIRCGADWLHMDVMDGHFVSSIVMGPPAIESVRKHVPEAFMDCHMMVSEPLKWIQPIANAGGSSYTFHLESTNDPVEVIRQIKASGMRASIAINPGTPATEISDEIAHAVDMILVMTVWPGAGGQKFIAECVPKVAELRARYPELDVEVDGGVGPKTICACANAGANVIVAGTAVFRDSKPDAVIQYLREQCEQAQERIRTEREQILRGENIAGAGIAHSMTYLSGDKDAWNYPRAYMSTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1Z8</accession>
    <name>A8Q1Z8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1864</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730865.1">
        <property type="nucleotide sequence ID" value="XM_001730813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1Z8"/>
    <dbReference type="FunCoup" id="A8Q1Z8">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1Z8"/>
    <dbReference type="GeneID" id="5855172"/>
    <dbReference type="KEGG" id="mgl:MGL_1864"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1864"/>
    <dbReference type="InParanoid" id="A8Q1Z8"/>
    <dbReference type="OMA" id="EMAHSIM"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000759">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="152"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="334"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="503"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="557" mass="62622" checksum="3B468C9850E38732" modified="2008-01-15" version="1">MDLFSALTAGGTRFDKKRFSRDISLFQESRKRDENEHARAPEQSAGAALPASLDFFGSHKDERAVAEAEAGAAEDASKHRQRVTTQNNLPLQRSELPAFLRERQLKLTGTDVPLPLKTWHDLETRWHIEPWLYKNLLKGPWKEPTPIQCGAMSVMLDRRDLLAGAPTGSGKTLAFVLPTLQLLKRHQKHGFRAVIVSPTRELAQQIFSQLQLLADGEAFRTCLLTNVTKATSDSIKKKKFDILITTPLRLVHSIEHEELDLSQVELLVLDEADRLLELGFLEQTDAILAACTNPSLRKALFSATLPAGVEELAKTFMVDECRVLVGQKDSATATIEQRLEFTGSEDGKLHALRALIQAGGMQPPVLLFVQSIQRARELFHELVYDGLHVDVIHSERPKAQREAVIQAFRRGDIWLLICTELMARGIDFHGVNLVINYDFPQTVQSYIHRIGRTGRAGKQGKAITYFTKDDAPYLKSVVNVMRQSGCDVPEWMLKLPKPSNMLKKQLRKKPVQRKDVRAASGSTSFGRRLANRQRDMVQASKRRQKSKPQAKSPMPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q217</accession>
    <name>A8Q217_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730873.1">
        <property type="nucleotide sequence ID" value="XM_001730821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q217"/>
    <dbReference type="GeneID" id="5855180"/>
    <dbReference type="KEGG" id="mgl:MGL_1872"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1872"/>
    <dbReference type="InParanoid" id="A8Q217"/>
    <dbReference type="OrthoDB" id="3350614at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="375" mass="42303" checksum="79EB020E09214D93" modified="2008-01-15" version="1">MIEPTSPSVKSTRSARSMSPSMSPRRQPDLLRLVQHPVAPLSSNVVAEPDMGRQALSPDLAKSSYPHTNTEPSTSEPGPSSQVTPAGSSDKLEHVEKLLHASLEHDAQQQRLHMDAGMAATGLPDDVSPTQATDPSKENKRVCFDERTFLRHETARPYQYETRTARRPNLHGHMAETRQYMDSFIQQLQSQIEGASARWNREPVQELVTYQARSGASSPVVVHHARAMSLFRPWLWTWRVLIEFHAPWLSRNTRMSPGIYGQLMTRARDIVSNALHETESLAGQERANAVLRWYPAFVLRGMHSLLAQYTPTNDVTHIAAPHQRWAWDVHVVTITMPTVALWHMDVVVATCLELLLVYTQLGLSLLLAIMQRIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q316</accession>
    <name>A8Q316_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730494.1">
        <property type="nucleotide sequence ID" value="XM_001730442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q316"/>
    <dbReference type="STRING" id="425265.A8Q316"/>
    <dbReference type="GeneID" id="5854801"/>
    <dbReference type="KEGG" id="mgl:MGL_2290"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2290"/>
    <dbReference type="InParanoid" id="A8Q316"/>
    <dbReference type="OMA" id="HHEKDAF"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11767">
        <property type="entry name" value="SH3_Nck_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="117"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="178" mass="19726" checksum="165D12841098DBAB" modified="2008-01-15" version="1">MFALPGKEREAFFDLLDEYFSQRPHLLQNYQRPSEEPVSSAPVGLKKPAPPPPPRQHQRQVNSSLGSTHTTNTNGIESDLQEMHVSPMHKDIRKPEGLTTTKQPPASVTASAAQTTSTLGEAVALYTFQGGQPGDLSFVQGERISLLEKVSDDWFRARNAEGHIGIVPTNYIERNYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3G9</accession>
    <name>A8Q3G9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translocation protein sec72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730601.1">
        <property type="nucleotide sequence ID" value="XM_001730549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3G9"/>
    <dbReference type="FunCoup" id="A8Q3G9">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3G9"/>
    <dbReference type="GeneID" id="5854908"/>
    <dbReference type="KEGG" id="mgl:MGL_2397"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2397"/>
    <dbReference type="InParanoid" id="A8Q3G9"/>
    <dbReference type="OMA" id="KMYTLAI"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23320" checksum="AA3A541785D8989A" modified="2008-01-15" version="1">MSDKKNPLADLPAEDATDEKGNPLLFAVDGDEMFPFSVDAKTNQVHTNAHDVSLLNLIANWLTLLPPQAPFPPPPHILQKQLTENIQEAKEKGNTAFRQKDYETAIKHYTLGVAMITSRPMWESCSLIADELTVMLANRSAAMYACEAYIEALCDADAVVKIKGTWGKGHFRKGKALAALQRYDEARAALDLGHQCEPDNEDFLKAIAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3M9</accession>
    <name>A8Q3M9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730656.1">
        <property type="nucleotide sequence ID" value="XM_001730604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3M9"/>
    <dbReference type="STRING" id="425265.A8Q3M9"/>
    <dbReference type="GeneID" id="5854963"/>
    <dbReference type="KEGG" id="mgl:MGL_2452"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2452"/>
    <dbReference type="InParanoid" id="A8Q3M9"/>
    <dbReference type="OrthoDB" id="3354845at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="86" mass="9663" checksum="56E09F165AFE2B69" modified="2008-01-15" version="1">MPKELPPVDLEHPSDLDFIVHAVHAYALDIGSERLRTRGRNAASLQDTMNHALSRWIYAARTRLIPNVHINGLALSDYAKQEAGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3X6</accession>
    <name>A8Q3X6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730095.1">
        <property type="nucleotide sequence ID" value="XM_001730043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3X6"/>
    <dbReference type="FunCoup" id="A8Q3X6">
        <property type="interactions" value="764"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3X6"/>
    <dbReference type="GeneID" id="5854397"/>
    <dbReference type="KEGG" id="mgl:MGL_2477"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2477"/>
    <dbReference type="InParanoid" id="A8Q3X6"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26615" checksum="CFCE9872DAB32DFC" modified="2008-01-15" version="1">MACIGPNSSLHFSPRKQWRMNEEAALCLSLDWSDRMRASSNDARLIVSQSNGTVCTVPSLGATGTVPHGLETWRAHDFEAWIAAWDCWTDGVVAWSGGDDLALKGWDIRTPCYEQERAPIFTCKRGYDEKLRLYDARQMRYPVNETHVGGGIWRAKWHPTLPQKLLLACMHGGLVVLDCAGLSNEASITEEPMEVVTRFDGHNSIAYGCDWERAAPNDHFIYSCSFYDASMHIWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3Z0</accession>
    <name>A8Q3Z0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2481</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730099.1">
        <property type="nucleotide sequence ID" value="XM_001730047.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3Z0"/>
    <dbReference type="GeneID" id="5854401"/>
    <dbReference type="KEGG" id="mgl:MGL_2481"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2481"/>
    <dbReference type="InParanoid" id="A8Q3Z0"/>
    <dbReference type="OMA" id="CLAAQMD"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000003">
        <property type="entry name" value="Atypical/HisK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000006">
        <property type="entry name" value="Atypical/HisK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000235">
        <property type="entry name" value="Probable nik-1 protein (Os-1p protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="174"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="359"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="451"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="543"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="635"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="727"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="801"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1169"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1290"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1290"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1312"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1333" mass="144778" checksum="AA61166047D27599" modified="2008-01-15" version="1">MATVLRPALRYSPLPLPDAVQADQGGDAGLDYVAALLQTIVQATRVPVASSFSEQATGSLGGKPNEQLHLVHLPIEGSSHAKVAEIQKLVDKLARRLWAEEDTHAVDKRAGPTFPMRGIPEPVSRLTAERVDPVLRSPHIAPILAAVAPTGMDPNEMLDYASAESGLSAAEELHLLRAQVRDIARVCKAVALGDLTQHIMVPVQGPVMVELKDIINQMVDRLGNFASEVTRVSLEVGTQGKLGGQAYVPGVEGTWKELKDVVNRLAENLTNQVRGVALVTKAVARGDLSKKIDVQAGGEILELKVTINVMVDQLRHFANEVTRVSREVGSQGQLGGQANVPGVKGVWKELTDNVNRMCLNLTEQVRSIGMVTTAVARGDLTKTIEIVAEGEMAQLKDTVNSMVAQLRVFASEVVRMSLEVGTYGRLGGQAHVPNVEGIWKDLTMSVNKMADNLTSQVREIARVTKCVAEGVLTEFITVDVKGEILELKDTVNNMVRQLRTLSDEIIRVSVEVGTEGRLGGQANVEDVKGQWQVLTERVNMMASNLTTQVRSIATVNTAVARGDLSKTINVEVRGEFLDLKHTVNNMVESLRTFSTEVTRVATEVGTEGKLGGRANVLGVDGTWKDLTNSVNTMAANLTLQVRTIAHATTAVARGDLTQKVTISVSGEILDLVNTINNMIDQLSFFASEVTRVAREVGTEGKLGVQAQKKDIEGTWGEITDNVNIMANNLTSQVRAFAQITAAATDGDFSRFVTVEASGEMDSLKTKINQMVYSLRDSIQKNTAAREAAELANRSKSEFLANMSHEIRTPMNGIIGMTSLTLETELSRTQRENLVTVSTLASNLLAIIDDILDISKIEAGRMNIEEIPFSLRGIVFSVLKTLSVRAAQKKLNLVYEVAPNVPDPLIGDALRLKQIITNLIGNAVKFTESGGIVALRCKLNSAPGAPETVLEFCASDSGIGIKQDKLDMIFDTFCQADGSTTRKYGGTGLGLSISRRLVNLMGGDMWVRSHFGKGSDFFFTMVVKCDKFTPEQLTERMRPYKGRRVLFLDTLHDQTGVTDMLVLLGLTPIVLHSIREALDQSSSFSRIDAIVTDSLVVVAQLRNVEQLRYIPINLVTPSVLSLNLTYCLDYGISSYINTPLGLEDLYYALLPSLESSAAAPSEGGNNSSYHILLAEDNLVNQKLACKILQNQGHKVDVVDNGEQAVQATEQCKYDVILMDVSMPVMGGIEATMAIRDREDSQNLEHIPIVALTAHAMLGDKEKCLQAGMNAYVSKPIRRVELVSTLNQILSQKSEPPSNDSGEQNNNATNLLSHPHDAPSEENFDKNPSAHTDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4I8</accession>
    <name>A8Q4I8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730165.1">
        <property type="nucleotide sequence ID" value="XM_001730113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4I8"/>
    <dbReference type="FunCoup" id="A8Q4I8">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4I8"/>
    <dbReference type="GeneID" id="5854472"/>
    <dbReference type="KEGG" id="mgl:MGL_2547"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2547"/>
    <dbReference type="InParanoid" id="A8Q4I8"/>
    <dbReference type="OMA" id="THLMKFA"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="471"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="657" mass="74104" checksum="319ED4C112B491D3" modified="2008-01-15" version="1">MKQEHGIKSEPEDVKPSVQQRGFRDIPLFSMGSSNAVTHLMKFATHTRVDPNNESQFTPPVKLNRKLPLRVKMPPAKPGDQVIDKWGKPVMDKEGHALKWPSHDVDLETIRPYLDIDKPAAQENDASTGSGTSFTRNRMFKKRVREVHKSSSSARRTRNEEYYPWVLEDFETPQEWESSREPLPNSLKALEAWYFAEKERRESRRELPAPEIKQEANSSSSTMAPHAPWVGQLEGDSDETSTSHHVLFAFDDRNAGGFKVVPVRRQYKFMQLHKRVLTSEQVEEEFERHQRSSETERWFMRDRYNTGAGLGAPGGSSSGQARGRMPALALPGQPSLGWQSSSRLVAVSGEPQRRADDDDDLFGTVRKNETTYDELDFEDSFEDDDERADGQDDDDADAKELDERLKREMVADRLDDAHVKREPDELDDAVAVNRRSGADNLLGSSEYGRHDDAMLTGSGRQMRKIMKALSRREGLDTYDSDEEAKNPYASEESDESDEELTVLHPERALLAAREQKARLEKTKESSAASTPPTRSETPELESGVKRKNETARLDEAKKKARTESRSTSPVRSGSPSARSLSPLETEIVQLISSGRVASTSDLVQHFRARLKQDLSLKEQLSSAVKRIAYMDKKENKLKLKESVLADAGAISPRGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4L5</accession>
    <name>A8Q4L5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730184.1">
        <property type="nucleotide sequence ID" value="XM_001730132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4L5"/>
    <dbReference type="GeneID" id="5854491"/>
    <dbReference type="KEGG" id="mgl:MGL_2566"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2566"/>
    <dbReference type="InParanoid" id="A8Q4L5"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="48" mass="5670" checksum="7617EA443937A820" modified="2008-01-15" version="1">MPVLRANVHFIVHSHPYLECIAYPLRSLVRTIVYFSLDPLHEIPQVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4N1</accession>
    <name>A8Q4N1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730200.1">
        <property type="nucleotide sequence ID" value="XM_001730148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4N1"/>
    <dbReference type="FunCoup" id="A8Q4N1">
        <property type="interactions" value="556"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4N1"/>
    <dbReference type="GeneID" id="5854507"/>
    <dbReference type="KEGG" id="mgl:MGL_2582"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2582"/>
    <dbReference type="InParanoid" id="A8Q4N1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="191"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="284"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="288"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="477" mass="53565" checksum="561EF9888E8BAA9B" modified="2008-01-15" version="1">MRSSAHSSHLPTSARFGASAAGSHGALTTTTTTVSSTAAPTRRIPRTREPEAMVIDDVNGSDKENMDVYVEPVDTRETKRVRMTENMESATAVDMASRERSTRTGAGVGLARVGMDDAPAAAPMTQVVPRAKDEGWEDLDKDDADDPLMVAEYVEEIFAYMRDIEIQCMPNGSYMDLQRDLNWHLRGVLADWLIETHAKFRLLPETLFLALNIVDRFLSMRTISLSKLQLVGVTALFIAAKYEEVLCPSIQNFLYVADGGYTDEEILRAERYMLKVLNFDLSYASPMNFLRRISKADNYDIQTRTVAKYFMEISLVDHRLLDHPPSLVAAAAVWLAREVLERGEWTPTLVHYSTYAEPELLGTAEIMLDYCLRPPAHLHFHKKYSSKKFMRASAYVMEWAKNTFPHAVITQDDVTVGKWTDEHGEKHALDMLRVDLYERHGHPRPSVLPLGPSSSDVDSPSQSPQAQEADAAYSATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Y4</accession>
    <name>A8Q4Y4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730290.1">
        <property type="nucleotide sequence ID" value="XM_001730238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Y4"/>
    <dbReference type="FunCoup" id="A8Q4Y4">
        <property type="interactions" value="825"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4Y4"/>
    <dbReference type="GeneID" id="5854595"/>
    <dbReference type="KEGG" id="mgl:MGL_2672"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2672"/>
    <dbReference type="InParanoid" id="A8Q4Y4"/>
    <dbReference type="OMA" id="GREMFYF"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="342" mass="38721" checksum="48586AC47960DA18" modified="2008-01-15" version="1">MPPKKKGGGGNSGGAPKVTVDKTFGMKNKKGAKAQQQIKVIQQQQSQTGKSREALAKEKRREEEKRVKAEAEKRMKVEGPPIVQPHVPFGVDPKSLTCAFWKAGRCDKGSRCKFSHSSDAQRKTQKKDLYTDTRDQKDDDDKKNDTMDKWDQDRLNKVINMKHGNPRTTTDKVCKYFLQAVEDGKYGWFWECPNGGEKCMYRHALPPGFVLKSERKEREALEKANEISLEEFLESARHKLGSNLTPVTPESFAKWKKERLDKKAAEEEAMRLKKATQAQANKMAGLSGREMFALNPEMFADEDDDDDDGALDMTTYMPAGWEQGRQEDDVPSEGVANLRVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q573</accession>
    <name>A8Q573_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730359.1">
        <property type="nucleotide sequence ID" value="XM_001730307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q573"/>
    <dbReference type="STRING" id="425265.A8Q573"/>
    <dbReference type="GeneID" id="5854664"/>
    <dbReference type="KEGG" id="mgl:MGL_2741"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2741"/>
    <dbReference type="InParanoid" id="A8Q573"/>
    <dbReference type="OMA" id="YNELACR"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="644" mass="71373" checksum="B73F38211F88B0F8" modified="2008-01-15" version="1">MALLQLKHAGTSVQARTQAMHLRRSILQQAIESSNFTYLHEVKGHRSCINALAFSRGSGQWMASGGDDMRIHVRDLYDFDEQRAGPPETSTYRTLARLFGHTSNVFSLSWSAQNKYLFSGGNDQMVLCYDLNYDNIPIHKITPRIERHTPTLTYSVHEYGIREVSTHPTNTNLVLSSSDGGDVHLVDVRLPHPHTAHSYYFRGQVASSQWNPNPGDGTTFAVASSHDPSAYVSLYDVRNLSDRNERLIRSSDALVRYATQLRSKLPSGLAMARPDPTGAQFDPSGRFLTADMSLYLPTLYAVNDSEPLATMSSEALRTHLSSHEPGGSPRTNALAGYKNSCTVKRGSFGFEAQSGELYYVAGSDDFRGYGWRIPQLEKLLDERRSISYNDWLVSDSVGTGDVWFKSTSSSTPTMLRPTELGLPAFTLEGSRSIVNSTLCHPTLPMIATAGIERLVRLHYATPMSLQHMRDDWHKLRPITRPRVRTANMTAVLRAMRRAQRFSLDSDSDSDAATDWGVSNPSLHVDGHLDTASHPEAENTGVISTTTHAPTSAELADEEAIALFDELLCEEEDRSIFSRIDRSSDSEDDSEIESDYENGDGFDGYTVTSTEAEVDDVTDSESNSEPPHIDVGALEFLLESDESDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5U4</accession>
    <name>A8Q5U4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_2817</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SMARCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729831.1">
        <property type="nucleotide sequence ID" value="XM_001729779.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5U4"/>
    <dbReference type="GeneID" id="5854138"/>
    <dbReference type="KEGG" id="mgl:MGL_2817"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2817"/>
    <dbReference type="InParanoid" id="A8Q5U4"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049898">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381:SF1">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MARR_BRCT_CHROMO"/>
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        <property type="entry name" value="MYB_LIKE"/>
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        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Chromo" evidence="17">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
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            <begin position="697"/>
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        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="13">
        <location>
            <begin position="702"/>
            <end position="744"/>
        </location>
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            <begin position="289"/>
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        </location>
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            <begin position="915"/>
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        <location>
            <begin position="1051"/>
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        <location>
            <begin position="979"/>
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            <begin position="289"/>
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    </feature>
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            <begin position="307"/>
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        <location>
            <begin position="824"/>
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            <begin position="849"/>
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            <begin position="1088"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50135"/>
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        <source>
            <dbReference type="PROSITE" id="PS50934"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP42617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1097" mass="120145" checksum="258A23FBD7426A4F" modified="2008-01-15" version="1">MSLNVNGYPDQGLLHDANTFARLDPLVQPLTSSLQEKSLPVPCKIAPLTGQQLAEFLYDLDTFQEQVLGYSAARPAYPDAADENERHPLRLPALLLQTYPSYSDFSPLSTNAPVFVVLLSCMTFLAEHQQTSWDMKDKGKRSLYVSMIAHVRADLCARNLIQPVRIAVSSDMTQAEASHLKTIAENLRCEWVDSVSRATHVLRPSTADGVTLAAQDGPPPESEYFRTLSHHQNKVLIHVWYRPDSYDTWVPDKDFSEPEPAPAPRTAAWCIDARWLRDSQLYNEMMNEEDYEMEEEEDKKEPETPTAQVTQSTASSADSVHQGTEAKDSETRRNKKHSLPDTITDDSASKRIKILVGSHPEGAQTVDLTGSQPIPGKKYESEPILTGTLGNLPVSDEVSHATTTNVEPLPARAANTSDANTEGVHDEAVQTARKYLAEQTQEVIIPSYSTWFDMSTINAIEKRSLPEFFNKKNRSKTPTVYKEYRDFMINTYRLNPSEYLTFTACRRNLAGDVCAIMRVHAFLEQWGLINYQIDPETRPAALGPPFTGHFRVTVDTPRGLTLMHXGTRPDAPVKSESEPTTHNVPTEGVSLELRKSIFQSTLKGSRPIDHAQADSLAAQASKELDTQKGKKPAYACDTCGVDCTPSRYQSIRVKDYALCPPCYLEGRFPTSMYSGDFVRLDESTFKHSGSAGGGAGRGDDDWSDEETLKLLEGLEMYEEDWGLISLHVGTRSREQCITKFIQLPIQDPYLEGTAQKDLGALQYAPRDPTSGQHVPLVPFAEAENPVMSIVALLASAVSPAVAAAAAQSALGTLTESMRHTIQRASASASASDSVEPPASEAPASAPKSSSEDRQPASAETEARKDPMDIDAAPPSSVASSGAPETKTDSPVYPGTEAIETRHAGAITNTHIDSSADAEAASHANNDQNDGAKGKEDLTSSHDGHTSADPNQRESVPKNDVERAASIALGASACKAFVLASHEERECQRLVQQVIELQMKKMELKMSQFEELESLLEAERRSIEAGRKQLYADRLAVQRQLSTVHELLRKASTVPQNVRPDEMARASSAANGVPQQGPVVRQAPGSEVPSDSNVGRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5W0</accession>
    <name>A8Q5W0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_2822</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729836.1">
        <property type="nucleotide sequence ID" value="XM_001729784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5W0"/>
    <dbReference type="FunCoup" id="A8Q5W0">
        <property type="interactions" value="655"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5W0"/>
    <dbReference type="GeneID" id="5854143"/>
    <dbReference type="KEGG" id="mgl:MGL_2822"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2822"/>
    <dbReference type="InParanoid" id="A8Q5W0"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="233"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="13">
        <location>
            <begin position="456"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="617"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1034"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1034"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1054"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP42622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1063" mass="122033" checksum="D0CFE8C9A444D9EA" modified="2008-01-15" version="1">MLVEQWSFRPKRTERERSGVVSARTSVGFVTGLPSSKTTTRTPTTTLMAPRAVDDRSGAAELERVSSLFPLTYPVPSPITHKGLVPTDDIVLEQELLRNPDNIRTWMSYISHVEETNFRKRPMPDQGLSSASVRMLGFLSDETLRLALQRIVSLYERALAVFPSSYKLWHRYLSARARFVLGDPIDGAEGRRHRLLQSAQHALEMGPSMLELRRSEEAQEKWEFSLDGTLGWKEWRSLAAAYERALQQLPTMPRLWLDYLTLFVHPACPPTFSKTHARRTFDRALRTLPPSLHLHIWRWYLRWAEICGSEVAQRVWCRYLRIDSSLSEPYVAMLLEMPEHLRIADGHANNIDGSIARHDEDEKDDDDDDSLTPVQERRVLEAAKRMLGLARSAWTGEYTSPNGKSPYQLLLDWLELAERFPESIGLPPDEETQLPMRHPDDKLPDSETNVLDRTLLPVRQIVERDGLARFPDQAGRLWTGLATYYIKRGDFDTAWDTFEQGMKTVLTVRDFTQIFDAYAETSENVISLMMEELEDDEDDEANDNTDTKDRAQQEAEIDRRMQDFEALMERRPFLVNDVLLRRNQDDVQEWEKRVTLWGDNDEMVIATYKNALETINPRKATANLHQFYIHFAQFYEDGGSLGRTDPSAVERDVAAARQIFERAVKVPFKRVDDLAEVWCSWAEMEVRNGHYDEALRVMSRATSPPSSHTKIQQISYYDDSLAPQSRLFKSLKLWAFYTDLEEALGTLESAKHAFDRILELKIANAQTMINFAMFLEEQEYYEDAFKVYERGVELFTYPVAFELWNVYLSKFVHRYGGNKLERARDLFEQALDKCPANLCKPLFLKYGELEERYGLVRKAMSIYERATRAVVDEDRYEMYLYYIAKAAANYGLVATRPIYEAAIEVLPDRDAASMCLRFATLEQKLGETERARAIYGHASQFCNPKTQPEFWKVWNAFEIEHGTEDTFRDMLRIKRSVQAQYNTDMANMATTVLGSANRAPSTAAPSVSDPMAMIEAQQTAKSARTGVPSFVAASATSRPATVASSHPEKLGTDNDIDDDDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q673</accession>
    <name>A8Q673_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729883.1">
        <property type="nucleotide sequence ID" value="XM_001729831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q673"/>
    <dbReference type="FunCoup" id="A8Q673">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q673"/>
    <dbReference type="GeneID" id="5854190"/>
    <dbReference type="KEGG" id="mgl:MGL_2869"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2869"/>
    <dbReference type="InParanoid" id="A8Q673"/>
    <dbReference type="OMA" id="NPFTGWH"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41799" checksum="CEA6FB71E9EC9680" modified="2008-01-15" version="1">MSASIRARGAADDADKKQAVAGIHEKGRITSAPSSARFNAALADFGLIMSLIFGGCCSNALTLELTTKQLPASGTLITLAQFVATTLISLVGEVEWTSAFGIPVLWLKRPSVPIRRWLIQVVLYFFTSILNNSAFAYDIPMSVHIIFRSGGMLVNMLLGYTVDGKRYSFLQLASVCLVTVGVVVATMSAMSSSDSATFFLPSTTESDYLFGVLLLSLALFTSGFMGLFQERTYGKYGRQHWHEALFYSHLFSLPLFLLQSRSLSNQIREANATPREWLSMCQTCRFNKLGLHVPSYYVRLALNVFTQLLCINGVNRLTSRVSSLSVSLVLVVRKAVSLVISVVLLNGQAGSISLWFGAAAVMVGTIGYTYGGAKRRPVPHAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q691</accession>
    <name>A8Q691_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729901.1">
        <property type="nucleotide sequence ID" value="XM_001729849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q691"/>
    <dbReference type="STRING" id="425265.A8Q691"/>
    <dbReference type="GeneID" id="5854208"/>
    <dbReference type="KEGG" id="mgl:MGL_2887"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2887"/>
    <dbReference type="InParanoid" id="A8Q691"/>
    <dbReference type="OMA" id="CACHKDY"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="319" mass="35764" checksum="36E26418B20B18DF" modified="2008-01-15" version="1">MSADTYSPPHATLNTGAKVSMVALGCFNDKDPNGIVPGIEAATKVGYTHFDTATFYQNENAVGATLRASRIPRESLFVTTKLSNFDHHRVEEAFDKSLNELGLDYIDMYLMHWPQANKDGDFFATDDTISFVDTWRQMEKLLDSRAGKVKAIGVSNFSLKNLTELLKYARIVPAMNQIETHPYNQDRELVQFCQDKGIVVSAYSPLGFANSPMLQDQDIVSVAEELGHGITPANVLLSWNVQRGVVVLPKSSHAERVKENFRLVRLNAAQVQKIDNISNDPKRRHQRLCTLYDSKTNTCLGWTYEQLGWEIPPVKPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6M1</accession>
    <name>A8Q6M1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730020.1">
        <property type="nucleotide sequence ID" value="XM_001729968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6M1"/>
    <dbReference type="STRING" id="425265.A8Q6M1"/>
    <dbReference type="GeneID" id="5854327"/>
    <dbReference type="KEGG" id="mgl:MGL_3006"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3006"/>
    <dbReference type="InParanoid" id="A8Q6M1"/>
    <dbReference type="OMA" id="NPFHELN"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20627" checksum="84A4EAEA60AEA09D" modified="2008-01-15" version="1">MSYYFCVVGTKDNLLYEADLSPASISSSSVTGTSSVTGTGATPDTDRQRHSTVFGFTNALGQWTSGFPLRPASITTQEAVKEENKLSNASSFTNERHHLQMIAHGSLDTLEDRQFLDSNISNVCTDIKFILLHQHKHEEGIRQFLMDVWELWVKVFMNPFQELDAPIKSSSFDARVRASAKRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6M5</accession>
    <name>A8Q6M5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730023.1">
        <property type="nucleotide sequence ID" value="XM_001729971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6M5"/>
    <dbReference type="FunCoup" id="A8Q6M5">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6M5"/>
    <dbReference type="GeneID" id="5854330"/>
    <dbReference type="KEGG" id="mgl:MGL_3009"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3009"/>
    <dbReference type="InParanoid" id="A8Q6M5"/>
    <dbReference type="OMA" id="KKSLVWI"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="99"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="301" mass="33653" checksum="5D005FEE92501BD7" modified="2008-01-15" version="1">MGKLVHGVSTVGAVSFLLLTLASRRSQRARFYLNSILCVISMALSSSIGVVCGLVLSLFPGKRFNVNYIVARSFHFFMKPLIGMYVEVEGEEHLKRRPAIMVGNHQSSIDTLYLGRMFPVNSIIMAKKELKWVPFLGQFMMLSGSAFIDRKSRASAIKTMNATGEHMRKNNLMLFVFPEGTRSNLSTPDMLPFKKGAFHLAVQTQLPIIPMVCENYHRLFDSKTRFEPGKIRLKILPPIETTGMTEKDVDMLCNTVREKMLSQLLSYANDVKQQKIEASSDSSGTSSSVNTRALPGLSARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6T6</accession>
    <name>A8Q6T6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_3051</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730065.1">
        <property type="nucleotide sequence ID" value="XM_001730013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6T6"/>
    <dbReference type="FunCoup" id="A8Q6T6">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6T6"/>
    <dbReference type="GeneID" id="5854372"/>
    <dbReference type="KEGG" id="mgl:MGL_3051"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3051"/>
    <dbReference type="InParanoid" id="A8Q6T6"/>
    <dbReference type="OMA" id="IERYEEC"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="210"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP42851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="650" mass="70658" checksum="CF1E5710D1956ADA" modified="2008-01-15" version="1">MNPNAPSFDFNPAAAGFVPRFLQQQQQQQQQQQQQQQQQNYDAYYSQGFTGAGFAPQLSAQPTAQSTTPSSAFSPASGIGPGPATGAAPLPPKAAAMASSKPAGMKKAVSVSIGGGKKPEQKSEQKPESKEEKTPVVKNAGATDSTAAPAAAPPDRSTGEVKGQAAKQQTKVEKKVAEKASVDAEKVLQDAKLATDEETLRDLFGDQEIKSHLNLVFVGHVDAGKSTMGGNLLYLTGMVDKRTLEKYERDAKEIGRDSWYLSWALDSTQQERDKGKTVEVGRAYFETSKRRYTLLDAPGHKSYVPNMIGGAAQADVAILVISARRGEFETGFERGGQTREHAVLVKTAGVQRLIVVVNKMDDPTVNWDKERYDEIIGKLSPFLRASGFNPKTDVVFIPVSAYSGANLKDKAPADQCSWYDGPPLLTYLDDLELGDRKMSSSLKMPVSEKYADMGTHVVGKIESGMMKKGNTLVLMPNKTNVEVVAIFSEIDEEVPVAVSGDNVRVKLKGVELDEVQPGFVLTDPRDPVHVVRRFEAQLAILEHRNIICAGYSAVMHAHSLNEEVSLAALLHYYDKKTGKKSRRGPPFAKKGMKIIALIETTAPVCLERFKDYAQLGRFTLRDEGKTVAIGKVTKLLSDDDVPDVGKLSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q761</accession>
    <name>A8Q761_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3307</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729763.1">
        <property type="nucleotide sequence ID" value="XM_001729711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q761"/>
    <dbReference type="FunCoup" id="A8Q761">
        <property type="interactions" value="617"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q761"/>
    <dbReference type="GeneID" id="5854069"/>
    <dbReference type="KEGG" id="mgl:MGL_3307"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3307"/>
    <dbReference type="InParanoid" id="A8Q761"/>
    <dbReference type="OMA" id="YPVGYMN"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="12">
        <location>
            <begin position="785"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="1039"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1088" mass="118310" checksum="2172BC5229708CCA" modified="2008-01-15" version="1">MDASAHDGATRANQEDRVKHEEADAQSGVPQVSVDGAHEHADEEKQEGEGVTEMGDADKGDRGNQEGDGQRELYEEEGEEEGKEGEEGEEDDEEDDEDEEDDEEEEDEDEEEDEDDDEDGDTHRRKKKQRRNRFLDVEAEVDNDDEEFEDEEAEELLREDGFIADDILDESREAQLKTAADNQRLDHVRRREEEMSAEALAEELRQRHARSSRYASQSDYAEVPQRLLMPSVNDPGLWRIRCKRGRERTLVATVLRRALTRETSGRPLRIYSAFCRDSLDGQIFVEARRADDVLDAFDGLAGAYTTNTKPFLVPILEMADLLKLQKKNTEVPVGGWVRIKRGKYAGDLAQVLDVAENGEEVGVKLVPRIDLTPQEHDTYTDRGGTQAEEAPSTRRSRRWASVRHRVFSMPKRYRRRTRTKSPTKRGGVWVFGGETFRDGYLEKDVRMNAIQVEDVHPSLDEVLKFTGETPAEGAGVDLNLLADASKQTSEATLQPGDHVEVFEGEQAGVAGIVDAMSGDVVTLELPNDALDGQKIEVPAKCVRKQFRPGDHVKELHDLVQIDAQTAGVMFKIERETFKVLDQHGHVVTLKPHQISMRRDSKRSVALDYNGHEVHVGDMVKEVEWPLTQFRQGQVLHIYQSALVFVHNRTYKENGGLFIVRANHIEPLAPTNVKPRTDPSQMNPALKAMDADAGANASGPRRGGRDIYAGKTVAIVRGPYKTYRGIIKETTGGMARVELHTMSKILTVPLDHMVEKNPVTGESRRLVGPAAPAAAPAMAMNPYAGGGMTPAYAGAAAGLAGAAGGKTPAYNPYDGSRTPAYGVGMGQTPNPYGSARTPAYPGMAHTPNPYGGRTPAYPGMAATPNPYGGGLMGQTPNPYGGGAPMGQTPNPYSAPTPNPYGGAGGRTPAYAGMAATPNPYGAPPLLGQTPNPYGGQTPNPYGGAGAGGARTPAYAGMAATPNPWAGAAAGPAAMMPPSSLINGIRVRVVRGVQGMQYQRGAYDNSTGHLMMHNPSVCKVKLESGTELSDVPVTCVETMRPKAVGDACIVTDGAWRGSHVTIEDIDAQRCEVRMSDGQTCPLPLTLLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7T6</accession>
    <name>A8Q7T6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L37a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729572.1">
        <property type="nucleotide sequence ID" value="XM_001729520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7T6"/>
    <dbReference type="FunCoup" id="A8Q7T6">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7T6"/>
    <dbReference type="GeneID" id="5853878"/>
    <dbReference type="KEGG" id="mgl:MGL_3116"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3116"/>
    <dbReference type="InParanoid" id="A8Q7T6"/>
    <dbReference type="OMA" id="EAMKRTC"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13288" checksum="022C57668956FD3D" modified="2008-01-15" version="1">MCCHIDHTCLQVLHSYRYAICASVLTPSQSKRTVKVGITGKYGTRYGSSLRRQIKKIEVLQHSRYTCSFCGKDTVKRKAVGIWGCSACKKVVAGGAWSMNTTAAATVRSTIRRLREISEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7T8</accession>
    <name>A8Q7T8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729574.1">
        <property type="nucleotide sequence ID" value="XM_001729522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7T8"/>
    <dbReference type="FunCoup" id="A8Q7T8">
        <property type="interactions" value="666"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7T8"/>
    <dbReference type="GeneID" id="5853880"/>
    <dbReference type="KEGG" id="mgl:MGL_3118"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3118"/>
    <dbReference type="InParanoid" id="A8Q7T8"/>
    <dbReference type="OMA" id="WVAKTSW"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="921"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1061" mass="118730" checksum="A4515E22E7BEEDEE" modified="2008-01-15" version="1">MDTLLRLFPATLSPDLDVRRASEHELRQLEGQPGMLAASFQIVASSDVDMSVRQAAAIYVKNRIAVCWDASMARGPTESPHVPEQDRQVVRTALLPTIASVPQTLRVHVASAMNSIVRCDFPDAWPTLLDEIVQLLGSGEQVQIYAGVRALLETVRAFRFDSAHAKLDKVVSCTFPTLLATVSALMDSEQSDLPAVGEIVYYAMKTYKTSMIVTLTQHQQSHESIVPWGTLMLRIVQKPVVLKNESGATVHEGAESSIDDEAKEKAPWWKAKKWTFYSLNRLFSRYGIPSQLPTGMKSYKPFAETFLHNFAPEILKAYLHTAHAIVSDNMWVSRPVMCHLFMFFVNSIKPKSMWHQLRPHMQQIIETLVYPRMCFSDEDQELWDLDPIDFVRMSADPLEELGTPSSAAASLLSTAVTRRTKSMFEPTLAFITQVLNAYPAQCTARQFDGALRMCITICSSMVHHERVQNMLDAFFVQHILPVLHSPEAFLRLRACSLIQAFDSAGMKWQTSQSLETAFRGVMDCMMDAELPVRVKAAEAMGELVAHDEVHNAVAPNAGRLMQELLKLSDETDLDVLMTTQEKIVNNFAEELLPFSVQLTQQMANSYMRLVQDNLAGGGDSQVDGVHAFNMDQCEEDKYFAALGCLSTMYQMVTTAESRPDILAELEKVLLPVVAFTIQSETLDLYDECFQLTDVLTYYQKCISPAMWDIFVLMYKSFKSSGVDYLSEMIGTFDNCASYGTEMLRQNAEYRHMLLDIFHTAMTGDQLVVSDRIAACQMAEVVLLLLKGYVDDAVPGIITTLLPFLQNTAESPSFLLRKWSMLVILETIYYNPTLAVGVLESQGATNAFFTMALPMLTKCRRVHECKVAIVALLSLMAMDPQTLPPTLTTGYPHLLNALLTQLKLLPKLVAQRSELHKVLDESLEGQDDDLENEGALDEFDDDADVQEDDNDYLEILNQEAARLRSRVASIDGDDAAAGDDDDVDDFLDDFDDDDVVYESPLESVPVYEPFRTVIQQLRTQHTSLFQSLTEGLSEQQQLVMQQVYDLQDSEKNGTTPAAGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7U9</accession>
    <name>A8Q7U9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729585.1">
        <property type="nucleotide sequence ID" value="XM_001729533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7U9"/>
    <dbReference type="FunCoup" id="A8Q7U9">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7U9"/>
    <dbReference type="GeneID" id="5853891"/>
    <dbReference type="KEGG" id="mgl:MGL_3129"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3129"/>
    <dbReference type="InParanoid" id="A8Q7U9"/>
    <dbReference type="OMA" id="CHDMYER"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="323" mass="36377" checksum="EFD44BBB289D6392" modified="2008-01-15" version="1">MSQQMSSMDLNSSQPRQLDVSARNLRMVADLGAGNGGTVSKVEHLPTGVMMAKKVVYIDAKPDIRKQILRELQILHECHSEFIVGFYGASLSDIHLYMCMEYMDMGSLDSIYQKHGPIEVDVCGKIVYAVVHGLSYLYEQFRIIHRDVKPSNILVNHQGQIKLCDFGVSGELINSMAHTFVGTSTYMSPERIQGDQYTIKSDVWSLGITIIEIAHGCFPFAIEMDDDPDATTRAGERRFEDVRSLSIFELLQHIVHEPPPKLNPEAHFPPSMVDFVKACLLKDPVRRPTPMELRTYPFMVMASVSNVSLVDWVQRLNAGTPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7V1</accession>
    <name>A8Q7V1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 25 member 38 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729587.1">
        <property type="nucleotide sequence ID" value="XM_001729535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7V1"/>
    <dbReference type="FunCoup" id="A8Q7V1">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7V1"/>
    <dbReference type="GeneID" id="5853893"/>
    <dbReference type="KEGG" id="mgl:MGL_3131"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3131"/>
    <dbReference type="InParanoid" id="A8Q7V1"/>
    <dbReference type="OMA" id="WGIYEEL"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="102"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="199"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32751" checksum="D7C4428374B32F70" modified="2008-01-15" version="1">MLQPMDFLKTRMQQERLPSQSSLTATQRLARAFRTVVDTYGYQGLWRGTVPTIARNVPGVAAYFYTLNELRWLVALWQVPMLSIPGATNTALLDTTSTMARLSNAGNMITGAVARVSIGLLLNPISIVKARYESSHFTKDAYPTLWASFRSLYRDGGFRGLFRGFSATALRDAPYAGLYLVLYEQHKQWLGQLTHSDTGTWLVVSTSGLCAGTLATLMTHPFDILKTRMQTTPTRLFQGTVGPDAKLSLFTAARHILTVDGWRGFVDGLGLRCARKAASSMIGWSIFELGNRWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q826</accession>
    <name>A8Q826_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3188</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729644.1">
        <property type="nucleotide sequence ID" value="XM_001729592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q826"/>
    <dbReference type="STRING" id="425265.A8Q826"/>
    <dbReference type="GeneID" id="5853950"/>
    <dbReference type="KEGG" id="mgl:MGL_3188"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3188"/>
    <dbReference type="InParanoid" id="A8Q826"/>
    <dbReference type="OMA" id="HAYETHV"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF2">
        <property type="entry name" value="ZINC FINGER PROTEIN RSV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="94"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="547"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="760" mass="81094" checksum="0AC2A601CEBBCF9D" modified="2008-01-15" version="1">MEEKELGENAPTKNDASTGTTAAVAPASSASLAVDKSQIPRPYKCPLCTRAFYRLEHQTRHIRTHTGEKPHACTHPGCDKRFSRSDELTRHLRIHSSDKRSAPGDAPSAVSSDDSRRGSQARRRTRGAPRGRGGASKVLRPHASAHDTHDTSWHSGHTNVPSSSSSSSSSSTSSSRTRPYASAYGAPSAKVTMASLPGNAAVGGGVSIATDPTLASALPPTVSAGGGDSEMSTLASLATGELNELHRQERESKVQHAMRAREHALPSSVKHDWAMLEDARYGISASEAPVPVAPHPYVYGPPPPPPPPMSYLDEHARHRHADYAYYHDRYRDQRYERDASHYYVPATTSSAYGPRRYASLPGSRDVSPGPALPSRNTWDDSMPPQHHELEPHHEEAMVPLRSHVRSNYGTPSGSPVLGPLRTMSIFTAPNSPLASRTSSPVLGRSSNARIPVDLPRVSSHGSLASLPTEGPSHTAGNGHHGSLRFRAHPYNDAGASAHVPRRSHLHYGTNSHYTPSLPPSTSGERSTTIADTHDDMVHEVKAPASPTSLHYHTHWPTPRSLRTRWDAPPSAAPGGAAASTYDGSSGSAQMRPTPPYFAHLPPSVATRSAPASAANSPPGSPRINSPLSLLHHQHQGSRAYSAYATIARQFTRCTRIYIWLNIWWCVIVALSSRPTSSYQGAWDQLVSLVCRAFMMMFIEPPSRITLPPLGHAVPASASSMATTPSASTQTPTSSAAAPSTSAAAAAAASATTGAVTRALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8D7</accession>
    <name>A8Q8D7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729708.1">
        <property type="nucleotide sequence ID" value="XM_001729656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8D7"/>
    <dbReference type="FunCoup" id="A8Q8D7">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8D7"/>
    <dbReference type="GeneID" id="5854014"/>
    <dbReference type="KEGG" id="mgl:MGL_3252"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3252"/>
    <dbReference type="InParanoid" id="A8Q8D7"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18780" checksum="F79E430AD0756378" modified="2008-01-15" version="1">MYTVVFVSRYLKLFTPPSAYLILMKIFFISSSAYILYLMKVQFRTRHEADIDTIRLDLLMGIPAILALLFNYEFTIAEVLWSFSIFLEAVAILPQMFLLQRIGEAETITTHYIFALGAYRALYLLNWIYRYVYRAFVSANAEWNLTLFLTQAYFRGQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8J8</accession>
    <name>A8Q8J8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kri1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729739.1">
        <property type="nucleotide sequence ID" value="XM_001729687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8J8"/>
    <dbReference type="FunCoup" id="A8Q8J8">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8J8"/>
    <dbReference type="GeneID" id="5854045"/>
    <dbReference type="KEGG" id="mgl:MGL_3283"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3283"/>
    <dbReference type="InParanoid" id="A8Q8J8"/>
    <dbReference type="OMA" id="YAMEDRE"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="385"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="500" mass="57980" checksum="9E421C43297EEFE5" modified="2008-01-15" version="1">MTLQDYQRSRMLDAMKHSSDPAKDFAEATMHNGNNDDQPIPTTHDDEQEAIRAEFLRAAQDSEGQDDLFQVRKAEGGDESTYHSTLMGALGKDASEDKIRELLRDHTHDESRSKENEDFLMNYILNRGWVESDIPSSTSEPVRNWDAEAEDLDSEASFDSAAEAFEHAYNFRFEDPSLAQKSFAIESFPRHSEDSIRRPDDRRKKARHDRAARKKEEKDSKMRELNQLKALKRQEIAEKLKKLREVSGSDNRMDGHAFDGIDFDADFDPAEHDRLMQSQFDDEYYAMEDREKPRWDGDWEIDDIISSETKPEKKKKQKPASEEGMDADFVDNQDAKLSKKERKALKKKEKKAAKNKGKQEHEVDADDMDADKTESQITETDRKQKARDLMDEYYNLGYEDMIGDTPTRFKYASVPKDNYGLSAVEILLADDADLNNVVGLKHLQPYRRGPSKPSNLKKRLKRFREDLDAREQPVEQEERPKKKRLGKKERQKLKTQDSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8X1</accession>
    <name>A8Q8X1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729323.1">
        <property type="nucleotide sequence ID" value="XM_001729271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8X1"/>
    <dbReference type="STRING" id="425265.A8Q8X1"/>
    <dbReference type="GeneID" id="5853630"/>
    <dbReference type="KEGG" id="mgl:MGL_3358"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3358"/>
    <dbReference type="InParanoid" id="A8Q8X1"/>
    <dbReference type="OMA" id="RDEPRMM"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="493" mass="53921" checksum="AE9C961ABE22BBB3" modified="2008-01-15" version="1">MLSSKDVVLRAHTGSGKSFAVLLALLARPRLLFQSRSGAEPPVPGISALVIVPSNELAYQYMRWAHELMPAQLSAHMDAVIQCVVRGEATMDAQMTRLRETPPHVLIGTPTRLQECFAMAQGAHLLGLHTWRTLVLDEADALLNLPGRFPSEKQRWKHLTHPSPGLHVLDTIMRSRATFSGGERLPNAGMESYGPKRGADRRPPEPIRRTQYKGVENTTDHAPALARGIGIVPLQLVCTSATANSVLRHFLSARTGWLRTNTRETRDSAQWIDLTGQSGQLSAVGAPYRGSMPRELTHSCVVVDEVHGSPQPRLLDTTRGTAVPPALRKPASTSTTPAIQEHVVDLPLLEMLAYLYASEHVRRGLALVPARWSVQRVHDELAALGVPVKIVASGQIMSSSEDAMYVLQSTSARGLDIPNMSHVFLVGLQAVRDSLHYTHAAGRVARIGPDGQRPRGHVVTLIRGNSAAEQKMSQIYKRVGVELRPLQLRSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9R0</accession>
    <name>A8Q9R0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729505.1">
        <property type="nucleotide sequence ID" value="XM_001729453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9R0"/>
    <dbReference type="FunCoup" id="A8Q9R0">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9R0"/>
    <dbReference type="GeneID" id="5853812"/>
    <dbReference type="KEGG" id="mgl:MGL_3540"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3540"/>
    <dbReference type="InParanoid" id="A8Q9R0"/>
    <dbReference type="OMA" id="APKFALY"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="155"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="406" mass="42422" checksum="615310BCB39D23A4" modified="2008-01-15" version="1">MSKCGSNKQNEGAPVASVTVAVRAGPRFESEAGVAHALKNFAFRSTKDRSALRIVRETELNGGVLSASLSREHLLLTAEFLKGDEAHFIELLANVVGNGKYCRHEFNEDVIPSMVADSEQASQDPVALGMDALFSYAYRSRGVGSSLFASPSSPVTVEAVRAYAAQAMNKSNLAIVSSGLSDATLRSLVSKHFENVPAGSALKAAPSKYYGGDCRAAMTDAHGHGLPVDHFFLAFEGASRVNAAPLFVLESLLGGNSSVKWSAGLSPLSQITGAKAHAFNISLQDTGLFGIHVIAPSAKVSEAAKAASQTLKAAADSVSSEDVARAVAKAKFLAAQDFEGTRALSHETIATGLLDDSSASLDSVLDKFESIKAADVSSAAQTLLKSKPSSVALGDVKQLPYADELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9W8</accession>
    <name>A8Q9W8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729096.1">
        <property type="nucleotide sequence ID" value="XM_001729044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9W8"/>
    <dbReference type="STRING" id="425265.A8Q9W8"/>
    <dbReference type="GeneID" id="5853403"/>
    <dbReference type="KEGG" id="mgl:MGL_3563"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3563"/>
    <dbReference type="InParanoid" id="A8Q9W8"/>
    <dbReference type="OMA" id="PTSYECG"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08285">
        <property type="entry name" value="NADP_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF4">
        <property type="entry name" value="NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="10"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="353" mass="37944" checksum="D69E3FF2DE90B50A" modified="2008-01-15" version="1">MKGFAMIKVGETGWIEKPRPECGPMDAILRPLAVSPCTSDTHTVWKGSIGERHNLVLGHEGCGVVDEVGSQVKDFKVGDRVMVTAITPDWCSVEAQGGYPMHSGGMLGGWKFSNVKDGFFAEFVHVNEADANLAHLPKNISTAEACMLSDMVPTGFHGVELADVQFGDKVLVVGIGPVGLMSVAACKLRGASQIIAVGSRPVCRQAAKYYGATDIITYKEGPIDKHVLDLTNGEGVDKAVIAGGGVDTFDPVIKCLKPGGKIGNVNYLGEGDYVNIPRVEWGVGMGHKQINGGLMPGGRRRIEKLADLITYGRLDVKPLLTHRFDGFEHMEDALMLMRNKADDLIKPVVVFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2023-06-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9X9</accession>
    <name>A8Q9X9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729099.1">
        <property type="nucleotide sequence ID" value="XM_001729047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9X9"/>
    <dbReference type="GeneID" id="5853406"/>
    <dbReference type="KEGG" id="mgl:MGL_3566"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3566"/>
    <dbReference type="InParanoid" id="A8Q9X9"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="39" mass="4295" checksum="33B1C2C95F149065" modified="2008-01-15" version="1">MISLVLVRNSAPAQTRCLLKNDCNVIKFAQTRVTSKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA40</accession>
    <name>A8QA40_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729132.1">
        <property type="nucleotide sequence ID" value="XM_001729080.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA40"/>
    <dbReference type="GeneID" id="5853438"/>
    <dbReference type="KEGG" id="mgl:MGL_3599"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3599"/>
    <dbReference type="InParanoid" id="A8QA40"/>
    <dbReference type="OMA" id="EINESHY"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="355"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1338"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1389" mass="151958" checksum="8744AF998DE7C685" modified="2008-01-15" version="1">MQQQQEQQLQQTSYTSPYQQQQQQKVQQFMINQTQSSHMQQQSFQEQSQTPSTSVPQLESLQLQAQTELQQKQLLDNTLSTQPQQPQVQPVLAPQQQTGFGVAPTLSDTPPAQPLPMPHTSRQSATPTQAISSAQMLQLLQTNMSVLQRQWTITNAQPDGPNKVAALQYLTLQMRRLMNTQESILQTARDPNKQTEVTRDANSAHMRLTTSSPLVSAPAASSQIPMSTLMPMHVTQQSQNSSPVMPPSQSTSHAASFRSSMTPGPNPTFQPSVNMMHTPDPKPDPNHSVSLSFQNHNAGEPTPQLMPPQSDSQSITSLPQSQQPSSLTQVQSQAPPQPQTKSTPMSAQQTTIPVNPVPRDFVSTVYLFLAQRGVALPPDWSSPFVGPAANGRPGEVRSIDMQSLFAKVISYGGSEQIFSMPNGWAFLAQQLNLAVEPSNNTGSLNAIPTPSEVPGRLAAYYTQRLSLFERSWIASQRRNVSDSSCSGTVMPDRPGSDLHGNLAPRATSNRESVPPDSRSLNGAGSPSSAQIGMSATTVGGSPSMPIQNHPFGHLEPNQVHMAIGQHLNQLQALVSAGQLTPQMAMARYSAIQQALQAYNNERVVNSNSTNPAYNLQSPSSVTLPATPGTTLSQSSPKVSYQPQQHYQQQKPVQLSHQEQPPKQPTQQPYQPQLQPPQQPDPKVQPLSQQVPPQSQPQGQPSLPPQYQTHWSQPQELPSNMPNTQIPSVLQTAVLPVSSVPPSERILNAHLSNGPTSLDKSSSNSGSQVPQQHAKSDTSSHSGATRSTQTHKPAASKNSLPLLSTPPKHPALGRAQSEAPTESPDVIHSSPTHKVSAYVTDMHSRSQGRTSMDTIVPNKYKIEYLPSEVKLHTYGGRDLDKMDHELAPRLAEHARALSVKELGMVDIFGLTMSLQSGMSFEVAYALNTLLILSAGVDAPANYQFPLAPCEDLLDVLLDLLEQVMPPDSIESSVEYMDERDMLTYCDAVDMALQDEGEVRKWRRQSVSLSEEHAADQRVAVAQAIVTIFRNLAIMPDNMLFLSTHQRFMPMIASISRSILHDKRWGRYANATNSMFSLRELLDIEKDLLTILLGVSGESFDLTRFSVDSTVALVDMLRFFILDALEFESRQGASPMALERIGSLSSKSASSAWSTTSSSIVSFGASDLAQSLFLFYQAPHHAFLALQALSRLSLPDHNRELLARQVPAYIQVQLIHKLVAFLPVSSADFRRLASFTRLEYTETVAFCLYNVVYLAPPSVKVTIRDRLGITGTLFRAAKHLLLSGKDYTQNPYNVLSRRLIETMRLLSDGKDYFGVPPLLGMNWPLEEASTAPSTGQDAVSLSPSPSMTSRSPPPSCSRAGVLCGQDDKIIEVLVRTANLDASLTSELLALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA66</accession>
    <name>A8QA66_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ELYS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729158.1">
        <property type="nucleotide sequence ID" value="XM_001729106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA66"/>
    <dbReference type="STRING" id="425265.A8QA66"/>
    <dbReference type="GeneID" id="5853464"/>
    <dbReference type="KEGG" id="mgl:MGL_3625"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3625"/>
    <dbReference type="InParanoid" id="A8QA66"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55615" checksum="A6A5EC039D3AAB47" modified="2008-01-15" version="1">MIRELLSLPLCSSEEAFLESYTLESLDRAQGAVALDTLLIKFVNQGRYIDAIHLDRRATYHERTLTFSEQEQDTYSRAKQRRRALMDGVWAVVPSIQRNALLVQDSEDDHSLGHAKDQYREEMDMDCISKPLARSHTPLSVSLGSKDVQGLRKSSADVNLLRASIRVPTASSSEPRGASPVHKVTERDSQWQSSTPFSGWKRSGLAQSMSVSPQPTWNLPIPSSSRSPRLSKRELGTGPISDVEDILEQRSSSIPSHNVIPAEDESMATTGQEVDAQKPTEEQDSIEEVHAEEPVRRRGGRRRAARQATEALRKALRPEEESSGPSIPGGFPMEEDATPLAQPTPRRSARRSTRRSRKSTTAAAETATPENISTSMSMYPELPGSKSSNTPRLPRSSTTSETTAYPQHSLARLEAISDVRPIARRTRAQTAELESHGSQINMDVGDVSEGADIATSVPATPSRARRGGSTRERTSTPQRVTRSTRRLRDARTATPGASHTSSTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA80</accession>
    <name>A8QA80_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729172.1">
        <property type="nucleotide sequence ID" value="XM_001729120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA80"/>
    <dbReference type="GeneID" id="5853478"/>
    <dbReference type="KEGG" id="mgl:MGL_3639"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3639"/>
    <dbReference type="InParanoid" id="A8QA80"/>
    <dbReference type="OMA" id="VFWVWNH"/>
    <dbReference type="OrthoDB" id="2155261at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="486" mass="54120" checksum="B5EE4A314979290E" modified="2008-01-15" version="1">MHQKMLTLPSRPAKRSFFARSSAWSKRAQPITPTALLQRIRQPVDRIPLDSMRQLRVALATESPAWLDEFLDASGYDTLLAHLDSLLRMEWREEQHDDTLLYEILRCIVALGSSKSGRSALIDQAPAPFEQLCVALYSDQIPKELEMRRMIVLLLHMLVGHDLPPTVLEKRSVHRVPVQDVPCLSFASKKHDGAALAAMLLHTPRPSTMENKVDFLQCAHEHRPLRKHVEELQRVCGEFFWIFCHENNAIWDWDSLDTQAAMAPRVPSGMTGSVEWEAIMYLTENLSLINAILASFLKSSAEAARAFVDELYFAQFSSVIQTLRLASQSYYTSMHAELAHWCALEKQSKQEALPFSPIPCSSAEPELIPTPLPVSTSTPASGPKPGPTSMPPMIQVEQSALEAATSPALVATPYFTPMLPSEPIRPHRTVSHIRHVSTERVSIPVSPRTNYSTITNKHTGPNSGQGVVASSVNNTLDDIDIANIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA86</accession>
    <name>A8QA86_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729178.1">
        <property type="nucleotide sequence ID" value="XM_001729126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA86"/>
    <dbReference type="STRING" id="425265.A8QA86"/>
    <dbReference type="GeneID" id="5853484"/>
    <dbReference type="KEGG" id="mgl:MGL_3645"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3645"/>
    <dbReference type="InParanoid" id="A8QA86"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="167" mass="18837" checksum="EB19B4A48A5E33BE" modified="2008-01-15" version="1">MTKREQESQHHYSHSKRRRKQGPRVGSAHQRHTRKIVHALDYPRCGGVFMSCARGKERKAASELIEVMEEKAQCMYGDVDEEDMDSLRNGPAPATRAKGAATPTSVNSSSDIETQIQQELQALRSTPSLSRFTALDTDTECCMSFRVLVSYMQYALSSVYHQLIRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA92</accession>
    <name>A8QA92_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_3651</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729184.1">
        <property type="nucleotide sequence ID" value="XM_001729132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA92"/>
    <dbReference type="FunCoup" id="A8QA92">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA92"/>
    <dbReference type="GeneID" id="5853490"/>
    <dbReference type="KEGG" id="mgl:MGL_3651"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3651"/>
    <dbReference type="InParanoid" id="A8QA92"/>
    <dbReference type="OMA" id="RISYKHW"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="112"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP41970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="209" mass="22153" checksum="1894E32ED3D21942" modified="2008-01-15" version="1">MFRVPKDAAYMKKLGSNIASGGAAGASSLVFVYSLDYARTRLANDAKSAAKGGERQFNGLVDVYRKTIAVDGIMGLYRGFFPSVVGIIVYRGLYFGLYDSLKPVLLPGKLSENFLASFFLGWGVTTTAGLASYPLDTIRRRMMMTSGGGVAYKNMLHAASSIIAAEGVYSMFKGAGANILRGIAAAGTIAGYDKLQQVMFGKVYKGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAB3</accession>
    <name>A8QAB3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TATA-box-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729205.1">
        <property type="nucleotide sequence ID" value="XM_001729153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAB3"/>
    <dbReference type="FunCoup" id="A8QAB3">
        <property type="interactions" value="729"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAB3"/>
    <dbReference type="GeneID" id="5853511"/>
    <dbReference type="KEGG" id="mgl:MGL_3672"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3672"/>
    <dbReference type="InParanoid" id="A8QAB3"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27970" checksum="7118E1A91EB91B3A" modified="2008-01-15" version="1">MSSSGSLQLPQAQAKVTSSDASQQKPLALPTQSKNPDTSSQNTADEDDKSAVKDTQSIPAPITEQTLSNMHGIVPTLQNIVATVNLEARLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVITGAKSEDDSRLASRKYARIIQKLGFEARFSEFKIQNIVGSCDVRFPIRLEGLAYSHGVYSSYEPELFPGLIYRMVKPKVVLLIFVSGKIVLTGAKSSFTPLPFSLLPLSPIPSLSCNVCIMNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAL1</accession>
    <name>A8QAL1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728982.1">
        <property type="nucleotide sequence ID" value="XM_001728930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAL1"/>
    <dbReference type="FunCoup" id="A8QAL1">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAL1"/>
    <dbReference type="GeneID" id="5853289"/>
    <dbReference type="KEGG" id="mgl:MGL_3770"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3770"/>
    <dbReference type="InParanoid" id="A8QAL1"/>
    <dbReference type="OMA" id="KMRGDKP"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="95"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="306" mass="32543" checksum="A55785F6480F1DB3" modified="2008-01-15" version="1">MTSDSTATANTSTPTPVCDVKSGSNMIASMQEHSHPGSHSHSHSHAGAGSHSHSHGGSNAVEHGHTHEIMDHPGKFGERDVPNYASRNWNERAFTVGIGGPVGSGKTALLLALCKRLRDTYNVGVVTNDIFTREDQEFLVRNAALQDPNRIRAVETGGCPHAAIREDISANMEVLEQLQAEYGTQILFVESGGDNLAAAFSVELSDFHVYVIDVSGGDKIPRKGGPGISQSDLLVINKTDLAEHVGASLDVMRRDADRMRDHGPTVFTSVRKDQGVDAVADLILAARRAAGADHAGHPPTKSHASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAL3</accession>
    <name>A8QAL3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728984.1">
        <property type="nucleotide sequence ID" value="XM_001728932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAL3"/>
    <dbReference type="FunCoup" id="A8QAL3">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAL3"/>
    <dbReference type="GeneID" id="5853291"/>
    <dbReference type="KEGG" id="mgl:MGL_3772"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3772"/>
    <dbReference type="InParanoid" id="A8QAL3"/>
    <dbReference type="OMA" id="ARRFINM"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="51722" checksum="709FCC34E47D2B23" modified="2008-01-15" version="1">MYERKVKEKQLRPDDNQRRIVSILDHLHYKLRHYEQPEVPDPEESIQNEAHADDGGHRGIFDTLSVWFSGKTNEPESDGQDAMRPKHTPQGLYLYGDVGTGKSMVMDLFYHTLPSNITRKRRVHFHQFMMDVHKSSHEFKKKMQAATSKRTSVGRSGRSGGGSKDPIEPVIREIARDAQVLCFDEFQVVDIVDAMILRRLLAGLLRYGVVIVMTSNRHPTELYKNGIQRSSFIPCIRLLETQYHVVDLNSGTDYRKVPQARYETYFETTNPQGLAEYEQLWSNMTRDEPVMEDRSLTVWGRPLQVPLCTSHVARFTFQQLCGEPRSASDYIALCNEFDVFFLDEIPLMNLDMRDLARRFITFVDAAYEAKVRLFSTSEVDLMKVFSGTTSMDEASSEQMRVLMDDLKMSMDDIGGSSIFSGQEEVFAFARLVSRLSEMGTKHYAEVSAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBY9</accession>
    <name>A8QBY9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728960.1">
        <property type="nucleotide sequence ID" value="XM_001728908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBY9"/>
    <dbReference type="FunCoup" id="A8QBY9">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBY9"/>
    <dbReference type="GeneID" id="5853266"/>
    <dbReference type="KEGG" id="mgl:MGL_3954"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3954"/>
    <dbReference type="InParanoid" id="A8QBY9"/>
    <dbReference type="OMA" id="RCLMGYF"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="7">
        <location>
            <begin position="200"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="625"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="660" mass="74533" checksum="0B2CB84CCDCEAF2F" modified="2008-01-15" version="1">MKSMEKERDTNSLSCDVPRQVCTQASTGEFAVSDRDEDTTIELSRPMPAPDPVKRQQFEEKLASTPLGSTSDGLLTLLRDHPELVSNRLAQEAERILPDESVTAPRLNASSVSNYAQSVYEGGNVTSTLFPNKTAHSSPNVAPTIPMTRADSQYSLPDTARNTLNSMGDPTIHTSVLRQSSTKKRVSRSMSISRNLGEQSNKPDFSGEKIVVAMVGLPARGKSYLSNKLMRYLHWREYEVRVFNVGQLRRARAREVFGQTNSSTHTASFFDSLNVEAKKKRDVLAHECLEQLIAWLKTGGNVGIHDATNTTKARRKQIADRVAQEPGMRLFFLESTCTDPKLIEENVEVKVRGTDPDYAHLTREQAKEDFLRRIKHYEAVYEPLDADGTESHYTYCKIIDVGRSATMNLISSYLESQIAFYLLNLHIAPRNIFISRHGESQYNVEGKIGGDSDLSERGWAYARALPQLIQDHIGDEPLTVWHSSLRRTAQTAGFLKYPKLMWKSLDELDAGVCDSMTYTEIAEFYPEDYASRDDDKFNYRYRGGESYRDLVVRLEPVIMELERQNNILIIGHQAIIRALYAYFMGYDQNELPYIKVPLHTVIQLTPKAYGCDEKRYELPIEAVDTHRERPSRSLSNSISDLRLEGDEALETNAATGKSSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2025-06-18" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCB2</accession>
    <name>ARO1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">3-dehydroquinate synthase</fullName>
                <shortName evidence="1">DHQS</shortName>
                <ecNumber evidence="1">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="1">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="1">EPSP synthase</shortName>
                <shortName evidence="1">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Shikimate kinase</fullName>
                <shortName evidence="1">SK</shortName>
                <ecNumber evidence="1">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="1">3-dehydroquinase</shortName>
                <ecNumber evidence="1">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="1">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name type="ORF">MGL_3989</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text>Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="1"/>
    <dbReference type="EC" id="2.5.1.19" evidence="1"/>
    <dbReference type="EC" id="2.7.1.71" evidence="1"/>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EC" id="1.1.1.25" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728822.1">
        <property type="nucleotide sequence ID" value="XM_001728770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCB2"/>
    <dbReference type="SMR" id="A8QCB2"/>
    <dbReference type="FunCoup" id="A8QCB2">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCB2"/>
    <dbReference type="GeneID" id="5853128"/>
    <dbReference type="KEGG" id="mgl:MGL_3989"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3989"/>
    <dbReference type="InParanoid" id="A8QCB2"/>
    <dbReference type="OMA" id="SWANMSW"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000514">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000406723" description="Pentafunctional AROM polypeptide">
        <location>
            <begin position="1"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinate synthase">
        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="EPSP synthase">
        <location>
            <begin position="419"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate kinase">
        <location>
            <begin position="915"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinase">
        <location>
            <begin position="1093"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate dehydrogenase">
        <location>
            <begin position="1322"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="1">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="1">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" description="For EPSP synthase activity" evidence="1">
        <location>
            <position position="864"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate dehydratase activity" evidence="1">
        <location>
            <position position="1212"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity" evidence="1">
        <location>
            <position position="1240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="922"/>
            <end position="929"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <sequence length="1611" mass="173022" checksum="8C15A61DAC8A5E51" modified="2008-01-15" version="1">MSQVSGGKVPSYHAPPFDSPLSGATIHELRCLDTKVQLGFHLVPHIAKTLITELPSSAYVLVTDTNLAKLGAIDKFRKAFEAIPGARLLVYELAPGEESKSRETKAAIEDWMLEHRLTRDTVVLACGGGVIGDLVGFVAATFMRGLKYVQIPTTLLAMVDSSVGGKTAIDHPHGKNLIGAFHQPRYVFIDAAWLLTLPEREFSNGMAEVIKTAAIWDAADFEKLESESASIRAAVMGDEARQQSAAQGHTLATRTSSQSLLLDVIRGSVGVKAHIVTIDEKETGLRNLVNFGHSVGHAIEAVLTPDILHGECVAVGMVLEAEIARLVHGLPQVAIGRLVRCLRLYNLPVTLADARIMALSKVRELTTARVLDIMRVDKKNAGAQKKIVLLSRIGATVEERASTVSDAMIERVLAPAMLVRESVSAPRPPLTIHTPGSKSVSNRALVLAALSGGTCRLRHLLHSDDTQVMMQALAQLRAADFAWEDNGATLVVHGQGGRVLASDEPVYLQNAGTAARFVTAVACLASSASCSGSDESSCHGVVHLTGNARMKQRPIGPLVDALRSNGARIDYVEQSNCLPLNVTASGALQGGRIELAADVSSQYVSAVLLCAPYAQNDVELALVGGKVISQPYIDMTIAMMQSFGVRVERVAEHVYRIPRTTYVAPSTYEVECDASSATYPLAIAAITGTTVTVPSLGRASLQGDAAFARKVLAPMGCQVEQNDVSTTVTGPPVGMLKALGAIDMESMTDAFITAAMLFAVATAPCDEYASSSTSASPSSTRITGIANQRVKECDRLRAVVTELAKLGVRAVEHDDGIEVFSTPISQLLPHASIYCYDDHRIAMAFSVLACVVPGAGTEIQEKRCVEKTWPSWWDVLGGPLNVPIAGARLNDALVSLVARSRQRGPPTPTTLYGRDASIVLIGMRASGKSHVGRSLAKLLHRTFVDADVVFSDMYDIGAFVQDHGWDAFRAEESRILESLLTQCSVGHVIALGGGVIESAASRALLARFREHVGPVVHIVRDFALIESFLATSDRPAYGEPLADVYARRLPLYAESSCMEAVNTGNDAALALSRQLRTPLGTPVPISPAFFLSLTFPRVQDAWSILDHASAGVDVLELRVDLLHADGQPSIDDVREQVALLRQYTSLPILYTVRSVSQGGRLPDEANEAYFALTRLGLRMGCEYVDIELTRPSDGIEELAQAKGQTRIVASFHDTSGTMHWMAPAMRRLYTRACVLGDIAKLVGFARTWQDSLDLESFRTRVAQEAPFPLIAINMQAAGQLSRIVNPLLTPVTHPALPVPAAPGQMSVRDIHHARHLLGLLPKRHFFLFGSPITHSQSPLIHNTAFELLGLPHVYARHETDSVDASVEALVRAGDFGGASVTIPHKLSIMQLLDSVSPHAQVIGAVNTIVPHRDETTGHMALHGENTDWRAIVDLVAKHDGGRTRACTALVIGAGGSARAALYAMHKLGASRILLYNRTFEKAVNLAEQVPVEWRVEPVDSLALAAKAKPNVIVSNVPAQGTSFTPGGADIVLPLDLLSSDGGVAIDMAYRPEITPLLTLAQQHQSWHGVRGIEILLAQAFHQFRLWTGLPPPCLDIETTVYAAYRAAAASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCZ5</accession>
    <name>A8QCZ5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_4063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728728.1">
        <property type="nucleotide sequence ID" value="XM_001728676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCZ5"/>
    <dbReference type="STRING" id="425265.A8QCZ5"/>
    <dbReference type="GeneID" id="5853078"/>
    <dbReference type="KEGG" id="mgl:MGL_4063"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4063"/>
    <dbReference type="InParanoid" id="A8QCZ5"/>
    <dbReference type="OMA" id="STRYMTR"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="98"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="544" mass="60255" checksum="27B6BFD965B45E5B" modified="2008-01-15" version="1">MPGSRLDELMRHPLLFSSKQTPPRYPIILCHGLYGFDVRGPFMGLEYHYWSATLDVLRERVGAEVYAFAVPPTGSIQQRAEVLHNLLLQQGFPPGQPLNFVGHSMGGLDARYLISCIRPREYKPVSLTTLATPHRGSPFMDWCNTNIGVGLELIDAMMSEVRPNTVPDDAPNRAPFSLKAPLFTRDKADVQKNPLSRALATVSTALSSYILALFDQPAYAMLSTRYMTRLFNPAVPNVPGLRYFSVATRTPAMSVLHPLWLPKLILDKAATTGSCGADADGSSAAHRTLDAGNDGLVSVTSAQWGEFLGVLENWDHWDIRGPGGTKRLRPARSEVDHDTQTGKWSAWWNRVSDWLPTRRGQSETRPAAQASHKDQEWNWREAALSEYEETTHTERSEMPFPAAAYALSSAYEKGVDAQEASKIAQRLADWISSHLPSSGKSVEADPSKPSDDSGMLLAYLTKDRPHRPDDAHDDSLGESRTARALRAKLDTMPTSSRAERVSTALLEIFPFLVNAGHDGSLGASNDTFERFWTAVCRNLYEEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD11</accession>
    <name>A8QD11_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728744.1">
        <property type="nucleotide sequence ID" value="XM_001728692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD11"/>
    <dbReference type="STRING" id="425265.A8QD11"/>
    <dbReference type="GeneID" id="5853090"/>
    <dbReference type="KEGG" id="mgl:MGL_4079"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4079"/>
    <dbReference type="InParanoid" id="A8QD11"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="60742" checksum="84FF4E1D5B329770" modified="2008-01-15" version="1">MANMMVSTHSGLPYMSRSGSDTGVQYERTVPFLDPGSYAPPVYMCVPPPAPRPQAARAYIQPQFMVPAYPPDAWYNAASLVPPHLQQHGWMPMPTTYALGPPMCAWDPHRHGYDQQHYGQAPRGGRDHSQEQHGPQHGHGRSQSFGFGHAHMPVHGLAPFHQSWGAASHETWNAWPPFPPPASYMLPSFSIQASVPNHRSDSTVSGAGLTQRVAASPVASAAAAVAAAPESAPPLPLEKTAVVLSDFGAEAVWKASAEIVGLRRSTTRSGARLSSFPEVRSLSPEALAHDENLSSSSHSSHSFAEPTTPPSPTPATAGKTLSEPTHEANLSPARDERSADLHRLVRAMGHMQQRPFPSLGHCSAHHSRMPSSERRARTPMKREREHSVLLGEVSPAFRHFTHQVLAQTLVSPMTLLLALHYVHMLQGTMWPDDGSGETHTALSLLAHPISTAPFKLLTLGLMMANKFLDDHTFLNKTWHEVTGIPLDELNRMESFFLCRTQFQLSVSDSAWRQHVQAVRAEVYVSESQEKNATSDSSRVVDTLDHILAAHVSGLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD43</accession>
    <name>A8QD43_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728776.1">
        <property type="nucleotide sequence ID" value="XM_001728724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD43"/>
    <dbReference type="FunCoup" id="A8QD43">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD43"/>
    <dbReference type="GeneID" id="5853073"/>
    <dbReference type="KEGG" id="mgl:MGL_4111"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4111"/>
    <dbReference type="InParanoid" id="A8QD43"/>
    <dbReference type="OMA" id="SKEQQDX"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000082">
        <property type="entry name" value="Myosin light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="91" mass="10094" checksum="CCD64AFFF52B5BD0" modified="2008-01-15" version="1">MCVFDYNTFTNILNRPNGFKPAGTPEEFIRGFQVFDKDGTGQIGVGELRYVLTSLGEKLSNEEVDELLKGVAVGEDGSINYEAFVRQILSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD66</accession>
    <name>A8QD66_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_4134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728799.1">
        <property type="nucleotide sequence ID" value="XM_001728747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD66"/>
    <dbReference type="FunCoup" id="A8QD66">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD66"/>
    <dbReference type="GeneID" id="5853079"/>
    <dbReference type="KEGG" id="mgl:MGL_4134"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4134"/>
    <dbReference type="InParanoid" id="A8QD66"/>
    <dbReference type="OMA" id="MRMMSVC"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="55"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="405"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="747" mass="84069" checksum="D08D70ECB9108F93" modified="2008-01-15" version="1">MSASVREANLHVGGSSGRIVHVTDIQGNTRLPRAQLLDRLRAQQGLAYVPELELVRDVLYLMQGISGTHVRLHHAWQLPSDNGSHEACTHMRLDFDEHAGMISPPTRDLIHRLAELGQLFERVQAFVDSHESQPVATHLTAQSLCHFLTGELQAHNALLTDLDAQWHAQAEGENLSPPLTLQRLAQVTSEPMMRMRLMSTIVESCRHAHGGALVSTIHTYTLTGHPFIRRCTATMLDHVSRPFFHTLSRWIYDGELDDPFHEFFVARAPPSQTRKPPLVDDLVVPTELGTDAADVWHNRFVLQLQMLPSFLSEHFARKIFSTGKSLHFLRDCCSSGHGHAEYGDTAQPSVALDPEQARLRTLGYGSAHRRELRYSDMAGLEHAIDAEFALASGHLCMRMLSTFRLLDHLRALKSYLLLTQGDFADALLETLGPSLARPASTLYQHNLSAALETAIRASNAQFDDPEILRRLDARSLEFGPGDTGWDTFTLEYRVDSPVNAVLDASAMAGYQLLFNYLWHTNRVAARITAAWSQLLSVQKAVLRSRHRKLVDRALMRQLRATLGHVCEMVHFVRHLQSFIELEGISYAWQRLEHDLTVTKPSDLDHLVDIHRTYLHMLISTTLMRGRRSASDHLASDVRAQLHGILAYADATDELGMYVTSELARLAGGVDPLSSAARTHAHVSQRLVNEHTQFQHRLQSMLAALERHPTLTVRDLARRWNFNNVYYRRERTTVSTSHATTTTSALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDD1</accession>
    <name>A8QDD1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_4187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728708.1">
        <property type="nucleotide sequence ID" value="XM_001728656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDD1"/>
    <dbReference type="FunCoup" id="A8QDD1">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDD1"/>
    <dbReference type="GeneID" id="5853017"/>
    <dbReference type="KEGG" id="mgl:MGL_4187"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4187"/>
    <dbReference type="InParanoid" id="A8QDD1"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="224"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="312" mass="35981" checksum="AE13BFAB50307FA9" modified="2008-01-15" version="1">MYDQGDALKLWTQGFFGKGSLSRSEPTWASRKIAEKEARQRGIITAEQMTQRRREERRLLKIERARAAVRAGIQLPDGITALGGELRDDDTLGRGADGELWRGDEDKPIVEAGVSRIKGLKYFSDDIQSTQVDTDEQEEHAEEEEEEDGQDVEHFQLTMIEAFFLAAMLGCLEVHDVNGHVRANLHANQKCLSLDTLYQLCMISYLPRFDAHNQLKWVRPDNPFLLSYVVYHHFRSLGWVVKSGTKFCVDFLLYKRGPVFSHAEFSVLVIPEYENEQDREGSPFMRHHNAGEKSWIWFSMMNRVNTQVQKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDL3</accession>
    <name>A8QDL3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_4220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000022">
        <property type="protein sequence ID" value="EDP41445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728659.1">
        <property type="nucleotide sequence ID" value="XM_001728607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDL3"/>
    <dbReference type="FunCoup" id="A8QDL3">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDL3"/>
    <dbReference type="GeneID" id="5852951"/>
    <dbReference type="KEGG" id="mgl:MGL_4220"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4220"/>
    <dbReference type="InParanoid" id="A8QDL3"/>
    <dbReference type="OMA" id="WTNFTTG"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="4">
        <location>
            <begin position="576"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="705"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="770" mass="87228" checksum="D0C23EA9E692E0F5" modified="2008-01-15" version="1">MDAVFGCPAHGNSTERLEPPVSAIWFHSHGRIWVPFPDEDNNALEEAWHRVKDELVQRARARHTDNQQRSPRSWLTTSLWGESAYNTDSVLPPRPPRPMPSEKQTEPTYRITDPDEPAEQRRFRVPVLEDRLFDVDMEHMIVRTVQVISTDTQMYPALWAGYDQQVIRATWFYVASDGACSPIACNTRLEEDIVNAYRTAEPWRLEHRLKGTLSKSRREDQAVQYDLPSVVSGAKIQFISAYSARVYAQNIGSKLFPFLREPTLVRGFENARELSERLGSSTRLSTWTRRPESTSPRRTPAASTAASAEDVRDKDTIERFGPISEEDSNATGIIGDRATPDPSVSPSLWVPLNEAFMSRAWVSRSPSTNPRVRDIIEDARPQDPFDDDCSMPSTSDQPPQLLFCIHGIGQKLSEDYASMHFVHDLDRLRTIMRAQAQDIELKPLLNGGRVKLIPICWRRNLQFDPEQESYTLQDIVNATSIPSVRTVVTKVLLDIPFYFSRHHDLMERSVLHEMNRLYRLFVQRNPGFEQNGGRVSILGHSLGSMLAADILKDQPTFVRPLHETDAPNIHMLSPHLLFNVRHFFCIGSPLPLLYYMNGARLIARRRYDDDVDDATSAEVGKMGCLASESVYNVSSAPILPEVTNSFQLYIATDPISFQMSALADAPYSRIVRPVHLPRDPSLLMDALEEPRVNVGKLLMRVVNEKQVPTTSGTQDQNTVPSTPRSRPIPLEDMERGEQRFNALNPNGCIDYIMDVGTSSSVCVRVHQSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQX6</accession>
    <name>A8PQX6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial presequence protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732757.1">
        <property type="nucleotide sequence ID" value="XM_001732705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQX6"/>
    <dbReference type="FunCoup" id="A8PQX6">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQX6"/>
    <dbReference type="GeneID" id="5857063"/>
    <dbReference type="KEGG" id="mgl:MGL_0532"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0532"/>
    <dbReference type="InParanoid" id="A8PQX6"/>
    <dbReference type="OMA" id="WEGFARI"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="1">
        <location>
            <begin position="68"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="2">
        <location>
            <begin position="206"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="107709" checksum="4B3A0D4E0E80D0A8" modified="2008-01-15" version="1">MATPAAGEAPIQLGTFRRLAREALPYAPDMVVEKWRSTATGLTVLWSQFENPLVNAYITLATEIFTDSGVPHTLEHLVFLGSKQYPYKGVLDSLANRAFAQGTNAWTANDHTAYTLTTAGSDGFLRMLPVYCDHVFFPTLTDAGFVTEVYHINGKLEDAGVVYSEMQGRENSSADLMELKTQRMLYPRTSAYRSETGGLMSALRVLTIDEIRDYHAQYYAPHNAAIVLCGPLDRTELFSALQSIDDRFVQMGTAKGELGPPGWKRPFVETASAMPPVIDGTELAGAGVDDADPPANRDRRRVFVNFPERDESIGEVQISWLGPTMDDSLELQALDVLSTYLTDSPVSPMQQEFVERDEPLCTDIYIGNNERAGRTVLSASFSAVPTAQLDELDGHLDRLLRRIVSQGIDMARMRTVLRRERERLLSQLEMRPADCFSDVLIHDFLYGRQDGSGLADSLDDMRRFDALDDYSSEAWTSLLTRYLIENARLVVVGRPSAALVQQLKDETQARVAQRRQAWGEQGAQACEQKLQLARQENDAPIPPNMLQSFRIPSSDTIAWIKLATAESGCRAAGECNEPLCDVATADDKTLQAHVDADAPSPPLSIQFDHISSKFVLVSVVMGTQSVPDDLRAYLTLYLSMVFSLPVQRQDGSSLKYEDVVKQLDEDVLEYDATIGIGSSFSETMAIEFKAPVAHYEKVVAWVYDLLWRSEFSLDRVRVAAAKLAQSLPEQKRDGRMVASALSRSMLFDNSTSTCEANTILRQAQRVPEMVDALQEEPERVLEHFNTVRNALLRPEHVRISVAGDIRSIARPLEPWRAYMPRALADAPPSLVLRPLPWARDICTGLGRKPALEGRMCALPAIESSYAVFTSRGLRGYTDKDYAPLVITLTILNAMESFLWRYIRGAGLAYGASIRNDAEAEQIHFLLYRAPNAAKAFLEGRKVVQALAYGTALDDGSHVALDETMLESANGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR01</accession>
    <name>A8PR01_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732782.1">
        <property type="nucleotide sequence ID" value="XM_001732730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR01"/>
    <dbReference type="GeneID" id="5857088"/>
    <dbReference type="KEGG" id="mgl:MGL_0557"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0557"/>
    <dbReference type="InParanoid" id="A8PR01"/>
    <dbReference type="OMA" id="WELCADY"/>
    <dbReference type="OrthoDB" id="3339607at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="534" mass="58252" checksum="CB0CC276E2F0ACC9" modified="2008-01-15" version="1">MNLMAKVDTINAGPSSVQALPMVMREIRTSTSSAPSGIAATAPGPASPPLPPTQSASSSPIASQSVSPPSRRSPSLNTSVNGANREPNDESEEEEMDEADFQAFEAQYRGQTDPAFVEPGSASADDQTAQMQLHEQLPAASAPTHHRAPRIRQHGDRVKPEHVRLLISKLVEILDTARMDVPDETQLAAIQVPSAVWAELAETVPDRTPSAWKSFFDEAKSQLWESAMQQHASRLAEARSSGHATANGESAQHEPVSDARPPISGRSPTREPAHARASEFVPTEPARNASDALDAPRTASRSAVVESFSTPSTHKPHDVRPFASTSTEPVSASAANVHTPQGQAIPPSFTPATVRIGQRSGHHDAKVQAREACSGLHDEEPSPTMERRHGTSPVTPGSPMPNMSVFSRLIRPHHSITRAERHRARALYEAHVWELCADYGLSHPKQLMPFMTRANGDVYRCRHRLQRYMERLSHKYRLGIPTLIELLEVHRGNLKLLIQVLDIQQRAYAAQAAQAQAPETQHATQARQMSETPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR02</accession>
    <name>A8PR02_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Shugoshin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shugoshin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732783.1">
        <property type="nucleotide sequence ID" value="XM_001732731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR02"/>
    <dbReference type="STRING" id="425265.A8PR02"/>
    <dbReference type="GeneID" id="5857089"/>
    <dbReference type="KEGG" id="mgl:MGL_0558"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0558"/>
    <dbReference type="InParanoid" id="A8PR02"/>
    <dbReference type="OMA" id="MEHEYEQ"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin C-terminal" evidence="4">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="565" mass="62688" checksum="9A7967903CA04C99" modified="2008-01-15" version="1">MAHALRDCGVRTPLAARERATSALPTPPQPPSRSHIVLQDDRPTTRVPAAYATPLASEFIAEVSEDMSPLPETPTREAWTPSQDSTPRVASPLRGDTCPISVTRRTHGRRQSTQVDDVFRLDANDSAGTQHVGDDGDMQFEEYEQFVDPVSEQEQGQEQECEPVFAMDMEHEYEQEPFVEDELIPEHEHEHEHEHEHDHVLQHESLHEGESESHPSSNTGSGSDSRSEMDHQLDPSMQNLSAHDTKQRTTPSTPPHPQPKRSRRTSIAMDPGLIDEVPDRTRRARKSINYALPKLNTKMRKPDPDESDAPDAKKPRTSQERRRSTRTARQVSSPSQPPKTGPNASVNKSSKESKELSESKRCGDVNQQHENELPPDSSNTGTQHPSPAPSTLPPATPPQDQVQHDPEPNHGQKQDSNSTIQDSPVSPLLTPKAAPTPRRPRRSRAAEPTRRATPQVPKQRAGTPTIPPSVSTASARPTVPAFQTRSNKPFVPSRGGKNPHASVLQQHSAQKMPNWASSLLHLSSPEPPSRQSSQQNKENYPERPRRPLQQTPYSTRRSSAFSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR12</accession>
    <name>A8PR12_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0568</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732793.1">
        <property type="nucleotide sequence ID" value="XM_001732741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR12"/>
    <dbReference type="FunCoup" id="A8PR12">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR12"/>
    <dbReference type="GeneID" id="5857099"/>
    <dbReference type="KEGG" id="mgl:MGL_0568"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0568"/>
    <dbReference type="InParanoid" id="A8PR12"/>
    <dbReference type="OMA" id="RSKYHIE"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="265"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="490" mass="53863" checksum="E6865CCE915EE59D" modified="2008-01-15" version="1">MAPKKDWEKYSKPDADADKDKDQIVPLDEDDIQLLRTYAQGPYANALKRIDQEIKEAEKRVNEKMGIKESDTGLAPPDLWDIAADKQRMSEEQPLQVARCTKIIPADANDPESNDAEGDGQGGQGSSGASGGRDTEGGTPSVLDNMLGALHGLSSSLNPASSENKDKYVINVKQIAKFVVALGDRVSPTDVEEGMRVGVDRNKYQIQIPLPPKIDPSVTMMQVEDKPDVTYSDIGGVKDQIEKLREVVETPLLEPERFVKLGIDPPKGVLLFGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFELARTKKACIIFFDEVDAIGGVRFDDGAGGDNEVQRTMLELINQLDGFDSRGNIKVLMATNRPDTLDPALLRPGRLDRRVEFGLPDNDGRAHILRIHARSMSVERNIRYDLIARLCPNTTGAELRSVATEAGMFAIRAHRKVATEKDFLQAVDKVVRQGSKFSSTSLYAQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR52</accession>
    <name>A8PR52_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732831.1">
        <property type="nucleotide sequence ID" value="XM_001732779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR52"/>
    <dbReference type="STRING" id="425265.A8PR52"/>
    <dbReference type="GeneID" id="5857137"/>
    <dbReference type="KEGG" id="mgl:MGL_0606"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0606"/>
    <dbReference type="InParanoid" id="A8PR52"/>
    <dbReference type="OMA" id="TYKLRFT"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="248" mass="27439" checksum="C3168E32AB773922" modified="2008-01-15" version="1">MRTTRDLFRGDQRALLAARQETRQRFLSAKEERDPAKIDEGLDMGEQVNYILKHNVVQGVADKEAENATYKLRFTEHTELGSNDTIKQVRPAPTLSEIEKTKGRNAPAQMRTFSTGRRVCASSQQDGPDPTAPLPRPVPRFPGLVILADGSSVRVTTTSPRHITRMTRDFTNHPLWNPLSGGRNEAEADDDMGRLGRFRRRFADDGAGHAQNSVSFDESDLSWMSGGREARPGAAVQAKKGKGGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR72</accession>
    <name>A8PR72_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732845.1">
        <property type="nucleotide sequence ID" value="XM_001732793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR72"/>
    <dbReference type="FunCoup" id="A8PR72">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR72"/>
    <dbReference type="GeneID" id="5857151"/>
    <dbReference type="KEGG" id="mgl:MGL_0620"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0620"/>
    <dbReference type="InParanoid" id="A8PR72"/>
    <dbReference type="OMA" id="QFIVCYE"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="126"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="427"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="617"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="729" mass="81046" checksum="13DAE4E5071F6217" modified="2008-01-15" version="1">MEDAPERTSRESNPSDPGPEPDYFQLNPSQPSPQVPQMAPPNHVWSSLLDAANEPRTSQSMPTKLADFRQPFPLPSLLRPPSSIAHVSPNKAAREPSVPDADKYTPLHPSLLIELMHNHPILDHPAPEHLLVLDIRPTSAFSRSHLRGSVNVCAPTTLLRRSEFTVERLEDQIFDDDTDRSEFRRWMSYTRREPTQTSGPSSPSSLPAKSTSWIVVLDTDSTKPTSLGRSSAGGGGPSLMGLLRKFDAASYGGMLCWLRGGFQSLAALPEAVSLLEHSPVATQPRAASHNLPRVRGLSLEAFCRKTTSNSNGGSGEEIQATNPFFDNIRQNLELSCGITDIVPLDMHFSDLQLSRLPKFLCDLAAMDPSKRAHHLAEQFFVVEKCEQQRLQSVMQRHSQESSLSLSNPAGTMNTRAPPPLASVHVSSRAAFPRLPSAQDSATDSFPLSITAALERGHDHRYRNFWPFEHSRVKFKSPASRAEYINASYVNPLRAWGAHRVYVATQAPLPTTFCAFWAVVWEQKVPAIIMLAREFESGRLQCDNYWDTPHAGPFDVRVVQKCVLTSADLGHVGEYGLHVLVRRTIEVRHKDLADEPVHSVQHYQFLAWPDHSVPETPDLLLDMIRLVHAETDTASDAPIVVHCSAGIGRTGAHILIDSVSTFLSRVHRVLETGQDDADGLSLAQAREYWNSSNDLVYEALMVMREQRMSMVETVRQYVFVYKAVIASLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRA5</accession>
    <name>A8PRA5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732232.1">
        <property type="nucleotide sequence ID" value="XM_001732180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRA5"/>
    <dbReference type="FunCoup" id="A8PRA5">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRA5"/>
    <dbReference type="GeneID" id="5856543"/>
    <dbReference type="KEGG" id="mgl:MGL_0007"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0007"/>
    <dbReference type="InParanoid" id="A8PRA5"/>
    <dbReference type="OMA" id="YFQVDNP"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="482" mass="52510" checksum="B2A3741759BC368C" modified="2008-01-15" version="1">MSGLEDLRAKYEAAGQSHVFTYWDQLSADEKAAFERQLRGIDPARLNAMVKQALDADEAARHEQNAKVEPPPTESQVSTVGDEAKSNYFYEIGMKAIAAGQVGVLLLAGGQGTRLGSSAPKGCYNIQLPSGKSLFQIQAERIAKLQELAAIYGRKTSVVVPWYIMTSGPTREPTESFFREHGFFGLDPANVVFFEQGTLPCISNEGKIMLDERGKVATAPDGNGGLYAALRVPVKDGEPSVLDDLQRRGIKYLHAYGVDNCLVKVGDPVFMGVCVDKNVATGVKVVKKTDPAESVGVVARKNGAFSVVEYSEIPPSLSEARDSNGELLFRAANIANHFYTTDFLMKDVPAFESKMAYHIARKKIPSIDLSSGERVKPSTPNGIKMELFIFDVFPFCADLAIHEVERKEEFSPLKNASGTASDNPETSRRDLLAQQRRWLEKAGATVTSGADVELSPKVTYGGEGLQNVAGRTFDQTKNIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRH4</accession>
    <name>A8PRH4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732278.1">
        <property type="nucleotide sequence ID" value="XM_001732226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRH4"/>
    <dbReference type="STRING" id="425265.A8PRH4"/>
    <dbReference type="GeneID" id="5856584"/>
    <dbReference type="KEGG" id="mgl:MGL_0053"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0053"/>
    <dbReference type="InParanoid" id="A8PRH4"/>
    <dbReference type="OMA" id="GHEENMS"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="135"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="434" mass="47191" checksum="B12BB2AB1B4DB788" modified="2008-01-15" version="1">MLEAAQLSTHNTSFPALPSRTPILVASQSVSLLDTWAEKLRSHAAAAAPTNVTETSGTYIPDSSDTWVLYDWQPAYAAKDVAECVGNDSDDEKVTSIVLIPEKHFAEASESTRDFDLARYFDALSEARAVSASMPWPRPRSFHTAVGHIIAYARVIKSTQTALDSNRCLLDACLPGMTFFATQQVHGRGRGQNAWISPRGCLQFSTLVSLPLHIGSKSVLLQYLAALAVVYGVSILYPSVRGRVRIKWPNDLYAQVPEERLGSICVTEHGMRKHFVKIGGILVTAVCTPEAFHAIVGCGINCLNDEPTTSVRALAHDDTPVTQEACAGAIMAALESLVRVFADVGYTFAPFAEAYEQAWLHSDQDVCLADMPNEPRRIVGITSDYGLLRTVPRQASIRARDACAWCATPVPGVVDVQPDGNSFDMLQGLVKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRI5</accession>
    <name>A8PRI5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732285.1">
        <property type="nucleotide sequence ID" value="XM_001732233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRI5"/>
    <dbReference type="FunCoup" id="A8PRI5">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRI5"/>
    <dbReference type="GeneID" id="5856591"/>
    <dbReference type="KEGG" id="mgl:MGL_0060"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0060"/>
    <dbReference type="InParanoid" id="A8PRI5"/>
    <dbReference type="OMA" id="FERWQYW"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="47"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="296"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP45071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="393" mass="44253" checksum="9A4126CA87A39DDC" modified="2008-01-15" version="1">MSRIMEDLEEGPDPVLEPSTTALRHENLNREMSPEPDLDLNLSRGMHQVWLVKVPKFLIEGWSHVERDDVPLGTVRVYDPDENGHQQMELLLPEAPRQAIPIEDLHLRAQYANVPRKYDMKLSSTTEETYMKNLYAFEEELLDDDDVASDLGVDEDIVPDSVHSKRPRSTGPARGLHKKKRITALTGTVTNETSIQPQKQTMVSTLPPASATDTKPARMIGKSRSLLTPEYREILRQRRIESSTPKRSVIMMDSGDAGMNNMLAAGVGKGHIKPRATNFVMGNAQARTNEQTEKFARIPRNELLDLLFSLFDKYKHWSLKRLREETQQPYAYLREVLSSIADQHHNGPYAGSWSLKREYSEGSRTGTASVSNGASASDKQADSGDVLDDMEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS60</accession>
    <name>A8PS60_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732424.1">
        <property type="nucleotide sequence ID" value="XM_001732372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS60"/>
    <dbReference type="STRING" id="425265.A8PS60"/>
    <dbReference type="GeneID" id="5856730"/>
    <dbReference type="KEGG" id="mgl:MGL_0199"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0199"/>
    <dbReference type="InParanoid" id="A8PS60"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727927" description="CTLH domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39297" checksum="890EAB97DB459168" modified="2008-01-15" version="1">MWVELLWVLGDWTSCLQVAKAAVACDFSSSSKRIELNDARLMTTTEKLQLLRSLRSSVQKEQAVPNCSVLAIAEHILQDTSVGDELIKSLQIYLDAIKSCENQWHLPLVLMCQKFLTMSLRARRKSVLRHREIRALTTRLLNEFPNNTILLHLLVSQEQYARLEQHVRHIMEELVLFDTHTDSEVCWQHALAVELAHARTSSVRNLIDRALHASPHSQSVWHAALDFEIRLAQSATSTRVSSSTSSSLPTSRIKALVYQALRFFPFDKAILLLAMHPALLPAFTMEEAQTLTKSAEECQLRMFSDMSDDQETDLAEQAQIPQLNVKDAQPSSVMDQIDAFLHEVSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS81</accession>
    <name>A8PS81_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732435.1">
        <property type="nucleotide sequence ID" value="XM_001732383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS81"/>
    <dbReference type="FunCoup" id="A8PS81">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS81"/>
    <dbReference type="GeneID" id="5856741"/>
    <dbReference type="KEGG" id="mgl:MGL_0210"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0210"/>
    <dbReference type="InParanoid" id="A8PS81"/>
    <dbReference type="OMA" id="CTHTKVK"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="57"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="162"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="339" mass="38171" checksum="E937A01FA0B1E47E" modified="2008-01-15" version="1">MSDEAAPQPGAMTSMDYYADSYAHFGIHEEMLKDEVRTLSYRQAIQNNPHLFKGKTVLDVGCGTGILCMFAAKAGAKKVVGVDMSNIIDQAKVIVKANKLDHIITLVKGKMEDVDLGLGPDGKVDVIVSEWMGYFLLYESMLDTVLLARDKYLAPGGVMMPDHATLYLSAIEDQEYKEEKIDFWDDVYGFDYSCIKEIALREPLVDTVELRSVVCDPAPLMHLNLMTVKKEDLSFKTPFRLHVTRNDYVHAFLGWFDIGFEACHKPVRFSTGPHSRYTHWKQTVFYTPSNLTVSQGDVIEGTLSCMPNARNNRDLDISITYKLEGANPAEGSMDYKMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS85</accession>
    <name>A8PS85_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0212</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732437.1">
        <property type="nucleotide sequence ID" value="XM_001732385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS85"/>
    <dbReference type="STRING" id="425265.A8PS85"/>
    <dbReference type="GeneID" id="5856743"/>
    <dbReference type="KEGG" id="mgl:MGL_0212"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0212"/>
    <dbReference type="InParanoid" id="A8PS85"/>
    <dbReference type="OMA" id="HASDENA"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06917">
        <property type="entry name" value="STKc_NAK1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035062">
        <property type="entry name" value="STK_Kic1p-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF21">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="346"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="271"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="636"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="967"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1081"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="765"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="907"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1117"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP45223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1241" mass="133466" checksum="F768A0273B25FAE2" modified="2008-01-15" version="1">MPFHDGVVYIRTPTSDAERVPRRYAKSHRSVDERVALSTPSSPSSSVAGSAPSAASAPAPAIPAALSYMQSSANAASDTHMMPSVASTSNISSLAGKMPTSESMAFSDLYRHSELPSTPTSPVPASMMTPAASAEMTGMLSSTGTSQRWASDDPHDMHKASSPSKIPHLRIHASDENAADADMAFPTLTPSSSTRSMRGMDSLIPMWSADGSTKLESPGSRIIRVPQRGVTTNESMDSMRSVPATSTSKPFSVAANRVAGTISRLTRLRNRQQPRVPPDVEASTRPAVATDTADHIHNSQPLALEGKEVPRRYTSRDGADRIPPWMPSSPSGNTSIRAQASPDAQFRRYEMIGRGSYGAVYRGLHVPSNKVVALKVIDLDTPDFDVSEIWHEVALLSQIRHTQPKNIVQYWGCWLNGPTLCIAMDYYEGGSIRTLMKAGPIAERFAAVVTREVLVALSYIHSVGIIHRDLKAANLLVTRTGQVMLCDFGVAASFVQGSARGKRSTFVGTPYWMAPEVILEGKSYDYKADIWSLGITVYEMVTGNPPYSQHDLHQAITLIPKNQPPRLPDNGQYSPLLQEFVAACLDAEPRDRLSADELARMRWMKAHAKVPVSVLTELLVQYNKWTQAGGIRQSLLPPIQTDVRPNVDESPQPEWQFDSETPSDTAPSLPEAETPTETPTDHPLYRLFEATHDSDDPTTRSTSRTVNTITSTPKNALATVKAVKHPPPLSQPLSVPESQSYPQLTQLPLPSHLHPYPTSHPPSPSQMQSQSQSQPPLPSLSSSSVSVSSPPRTNARPAGAGFSGSGSTPFRFGLGSRMTEQAKPPSSFSTANASSGHPASSSTTSTPPISGLSMSVPEAASAPTSISIPVSRKGSMDESAKSVISPLEPPSALDVMATSSSSVSTSPQLPESQSSHSVPTSPIVEDPVESTRSSPALRRVGHIPNRAMRQTPLRTLRLVSSSSSLVWETQSAKRSVDEGRDSTPSFLEEPYTAGSRPQGTLSRTRSRGHANTAAMTCAPASTVSELPRSRSVPGNRLARFLSKQKEADQDGSPEPTDSSTTNLATLPSSVSLTSLDPYSTSVANTSVPPAANARATSAHRRQHHGGSDPTMMGTARLRHDPTNSKRHVREYSDQAKRPDPRDMRNWTIPAAPNVADATSDLSATTQDVFHVPSKGSSVAPFEGPVLRTLDYAALLSRQELQAEMSRTVEDLCTWLDALAAGLDEVLHPPTRALHQHPTRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSQ8</accession>
    <name>A8PSQ8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732525.1">
        <property type="nucleotide sequence ID" value="XM_001732473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSQ8"/>
    <dbReference type="STRING" id="425265.A8PSQ8"/>
    <dbReference type="GeneID" id="5856831"/>
    <dbReference type="KEGG" id="mgl:MGL_0300"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0300"/>
    <dbReference type="InParanoid" id="A8PSQ8"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="132"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="410" mass="45700" checksum="476A26801A2D6C89" modified="2008-01-15" version="1">MDAPAEREWQNAENDDFDRREARENEHDSERQRSPPAPPRSSSRETYERRRSRDYDHRSSPPPRDAYDRGSSPPPPSRRYEDHDRERERDRGRRGYGHGHAYGRDDRYAGPPPSSFARSREPPVRPSPPPSNIVGAFGLSIRTTERDLEDEFARAGEVEKVVIVYDARTGRSRGFGFITMKDIETATRAIEQLNNVELHGRRIRVDYSSTTRAHDPTPGEYRGNPRPVGGDRFSRPQVARTVGVHLAESADGASVGVDVIAIVNLVDTTTHTMTGLLAIVVEVATMIIRDQAVAGHAVMTVVDHHPHGTVLDQALIQIIGVAVRVRPRACAHVARRHVTVTTMTGHTTIAGGHRRLPRTMVVSVSVPSTLNVQIVLPTMKTHLADMRMSRLSDTTKENKPQNKCNAMATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSS9</accession>
    <name>A8PSS9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">sterol 22-desaturase</fullName>
            <ecNumber evidence="6">1.14.19.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732535.1">
        <property type="nucleotide sequence ID" value="XM_001732483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSS9"/>
    <dbReference type="FunCoup" id="A8PSS9">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSS9"/>
    <dbReference type="GeneID" id="5856841"/>
    <dbReference type="KEGG" id="mgl:MGL_0310"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0310"/>
    <dbReference type="InParanoid" id="A8PSS9"/>
    <dbReference type="OMA" id="KCIGLEY"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="542" mass="61042" checksum="124673AF6B87D160" modified="2008-01-15" version="1">MSHGQSQQVWDTAMTGNETIPQHTLNTATAQEGFTAVQVAFAVLTVIVSLLALEQMVYRMKKGGLPGSKWTIPIIGKFKDSLNPTLEKYQESWNSGALSVASVFNIFIVIASSTDYTRKILNSPTYAEPCLVASAKKVLCHDNWVFLNGKTHVDYRKGLNTLFTSRALSIYLNIQENIYKKHFAKWVALGSKDAEAFMLPLRNLNLETSLRVFCGNYISDEGAQQISDEYWLITMALELVNFPFAFPGTKVYRAIQARKNAMKWFEHTAAESKKRMALGEEVTCLTDAWVKAMLDAREDRQNDDLGAEQRRILVRDFSDREIGMVLLSFLFASQDAMSSGLTYLFQHLADHPDVLRKVREEQYAIRNNDIDAPLTIDMIEKMTYTRAVVKESLRLKPPVIMVPYMARQPFPISETYTAPKGSMVIPSFWNSLHDPTAYPSPDEFRPERWLEGAESPAAKHPKNYLVFGSGPHNCIGKEYAMQHLIAVMGDASVLLNWEHKRTELSEKVMVIATIYPKDGAYLKFTQRPAPPMDAPAAVAAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSY6</accession>
    <name>A8PSY6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732563.1">
        <property type="nucleotide sequence ID" value="XM_001732511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSY6"/>
    <dbReference type="FunCoup" id="A8PSY6">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSY6"/>
    <dbReference type="GeneID" id="5856869"/>
    <dbReference type="KEGG" id="mgl:MGL_0338"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0338"/>
    <dbReference type="InParanoid" id="A8PSY6"/>
    <dbReference type="OMA" id="CSETHEL"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="209"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="746" mass="84581" checksum="D021791FC1A784A8" modified="2008-01-15" version="1">MLPASKTRIISASTSDEAPAPNGTRRFSLTPAFQKDNERKVEHTQTDHALDTTHTGRRSFSWTLTPLFESGISRIFSWSAGSRPRSFALAHSFQSDLIESNSKDQSCLHSHEPPNKEALGLASDTDLSRTPSSEIVWHDVPTCSETHELDPFSMMSALDTHPHVPVVTRIPSLAGIYQATTPAVEREPPEHDPNLWKYSKIPLVNQQIPAEKQDRLVHSCITDSSCWTNHQAAQAADYCWTADSSWMPLEEMASWLSGSGLVQTQAREYFFEKFDWTGSTVLEALRELCLRLYLLAETNKMDEILKTLSMRYIKCNPATPFRNAVAVHSVTYSLLLLNTDWHLADLERHMNMQDFVQNTKWALEETCAFEDVPETILEALTYMYTSIRTSPLELPEALKENFPVSKSEGGAMKRALSRGRGSLIKLNRVRSNGHQMRGNLQALSKPEEMSEVKLPDSNCGKFTDTECFLTSDMDCAIVHDPKQQWHGRKSRTLFHVELCCDSLRLFSTPQGIAKKLERVLPLAQSVAKLEPGARADMPYMSIALQDGSIHHFFASLTVMEKWARMCQYIGGRISHVPFHGGCSNIDYGWLHITSGMEALCNTVSPAPKTTANAAVNFWTKLFRGKTKLSSSVHTLQTWLPPDSTVSRTMLPLPEQTENLHQYIAYVKSELYEHERIKESMLILWRSDRRARHKALDNWRRRHDFLCAELAQYRTYVEALKDPPPFPFRSSDVQGEIPRRTDLVVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTF7</accession>
    <name>A8PTF7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732642.1">
        <property type="nucleotide sequence ID" value="XM_001732590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTF7"/>
    <dbReference type="FunCoup" id="A8PTF7">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTF7"/>
    <dbReference type="GeneID" id="5856948"/>
    <dbReference type="KEGG" id="mgl:MGL_0417"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0417"/>
    <dbReference type="InParanoid" id="A8PTF7"/>
    <dbReference type="OMA" id="INRMFTL"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="153"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="347" mass="38557" checksum="F24A971EB459ED1F" modified="2008-01-15" version="1">MLFGPSARTRKPADSWHLAAEAIQSAVGIFLRVFSSLAPGRWAIPVLRALLADLRWVSRCADDAANAASRESRTSHAHLEECARLLNKAFTACIADRHPVLEQSKKWGTYAMVGIVFATYFQLKSIALCKNIVRALGAGDLPPLDAFPRAQAVTFRYYMGRLAFMDEDYARAEAELSRALADTPRSAKAHVERILVYLIPVRLLHAQHPTAAFLDEYPRIRAAYAPLISACKRGNVRAFDAALQDPTLERSLVRLGVYLAMERARDVCITRLVRRVWRQQGGGTRVRLAPVGTALQWLNCASDAHGAEWLVATQIARGRIKGYIAHERQMMVLSATEPFPHASLTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUC8</accession>
    <name>A8PUC8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0656</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732063.1">
        <property type="nucleotide sequence ID" value="XM_001732011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUC8"/>
    <dbReference type="FunCoup" id="A8PUC8">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUC8"/>
    <dbReference type="GeneID" id="5856359"/>
    <dbReference type="KEGG" id="mgl:MGL_0656"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0656"/>
    <dbReference type="InParanoid" id="A8PUC8"/>
    <dbReference type="OMA" id="ARDECFF"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000005">
        <property type="entry name" value="Cytochrome c oxidase assembly protein subunit 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8420" checksum="016C6E48FCADDFCA" modified="2008-01-15" version="1">MSSSGESSVRTSPHLVSELNPKGIRPCCACPETKAARDDCFLKFGHNVEEHGESARKCEELVKRHRECMASLGFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUJ0</accession>
    <name>A8PUJ0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732104.1">
        <property type="nucleotide sequence ID" value="XM_001732052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUJ0"/>
    <dbReference type="GeneID" id="5856410"/>
    <dbReference type="KEGG" id="mgl:MGL_0697"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0697"/>
    <dbReference type="InParanoid" id="A8PUJ0"/>
    <dbReference type="OrthoDB" id="2349883at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="311" mass="34386" checksum="E81AD27B4717FA0D" modified="2008-01-15" version="1">MPATTLARVVMRPTARGKVLPNMLCRSLSNSLSVRQNKVSALDFQLSSADAIYRARLAALEQLLPIIKGRWGGAGFAVSQALGLGWLTDSEESVMRYVSSRAVYVPMWVVDAMFHLPCRGDNGSARASFISTNSTFPGNAWKPMDTLPLRPPPPRTDNSPPPTQALITPNDEPMTYTPFSRQRHLFPDVEIPEGISVLPFNISPLSLPDICKAADLRTSMVDLLSEGPALHINRRFTILPGVEIQVANLDTSRSDDTKAMLRMELDKLSFDMFACYPVMLPIHLIEFQYDAHGEKDRQATVALGAWDPSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUN6</accession>
    <name>A8PUN6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732136.1">
        <property type="nucleotide sequence ID" value="XM_001732084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUN6"/>
    <dbReference type="FunCoup" id="A8PUN6">
        <property type="interactions" value="617"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUN6"/>
    <dbReference type="GeneID" id="5856442"/>
    <dbReference type="KEGG" id="mgl:MGL_0729"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0729"/>
    <dbReference type="InParanoid" id="A8PUN6"/>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="260"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="474" mass="53576" checksum="6F005FAB4E05EDB5" modified="2008-01-15" version="1">MIRTIPDVEHTDLSKLCEAVHSYSKKHGQLKKAISRMIQLAMLFLQSPDTTDMQAPASFYAVLGKDSLQTALKDEPMGDSAATESMAVDDGGNSKASQGDKASGDKVEEDREGKEDDRITALLQHAKAIGDKSLDDAAKMKLMVTLRELTEGKVFLEVERARVSRSMSDMLYAQGDVNKAAETLQDLAVETFGSLGRREKVEFILEQMRLNLERGDMSRVNMLSRKINVKFFEDEAQQDLKLLYYDIMVKVGMHDGKYLDVCKYYREVLNTPSIRADQDKFRDALRHVVIFLVLAPFDHEQRDLLGRVDSIEPLDSVPEYKNLLKCFTTPELMRWPGIEALYGPMLRQLPVFSGSAAAEERWKQLHTRVVAYNIQVIAKYYTKIRLDRLAQLLDLSIEQAEEALANLVVNKTTHARIDRPAQIVSFQAPLSDAEVLNHWSGDMSKLLQTVEKVSHLVEKEWAIQRAGLVVKAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUR1</accession>
    <name>A8PUR1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732157.1">
        <property type="nucleotide sequence ID" value="XM_001732105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUR1"/>
    <dbReference type="STRING" id="425265.A8PUR1"/>
    <dbReference type="GeneID" id="5856463"/>
    <dbReference type="KEGG" id="mgl:MGL_0750"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0750"/>
    <dbReference type="InParanoid" id="A8PUR1"/>
    <dbReference type="OMA" id="QWDANAY"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF218">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727959" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="624" mass="68774" checksum="CFCB04AF5DC14248" modified="2008-01-15" version="1">MTRLFSWAAALSVVSVFSISQVSAYVGEVHNYTRRATTGNGWDIDGKSFDYVIVGGGTAGLVLANRLSADGSNSVAVIEAGPSGYEDNDKFIVPSAMLYDSAVNTQYDWQYKTTSQKHLNGKEKSWPRGKVLGGSSAINGLYYVRPSREEADAWAELAGKNGWNHWGWDNLLNGMKKSEKLQTPLKSVREQAHIEYDGRSHGRNGPIHTTWPAVTYGPVGAFIESASKVAVPRVKDAYDGENHGTYVALSSMNKRNWQRSFSRNEYLDPISDRNNLQVLTGHLVTQVIFDRSDKNHVQATGVHYKASVDEVEHTVHANKEVILCAGAINTPQILQLSGIGSSDLLNRHGIDVVVDLPGVGENLQDHISFGLSFRAKNDKDVAPQQITGNKKTDSYVNSAVSYVNFESLFKHPDHVRSKLQARARELAGEGKKNEAVRRGHEKTYESMAQHVFGEDVVSPVEILGNLIFGSINIQAALQHPLSRGYVRIKNKNPFEWPLMNPNYLKEDMDMTMLRQSLKLIRKISQESPLKDLIAHEDSPGSDVQSNEDLENWIRENAGTEYHPSSTCSMLPRSEGGVVAPNLKVHGTSNLRVADASIPPLSMSCHLESVVYGIAEIAADLILGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUW3</accession>
    <name>A8PUW3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732193.1">
        <property type="nucleotide sequence ID" value="XM_001732141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUW3"/>
    <dbReference type="STRING" id="425265.A8PUW3"/>
    <dbReference type="GeneID" id="5856499"/>
    <dbReference type="KEGG" id="mgl:MGL_0786"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0786"/>
    <dbReference type="InParanoid" id="A8PUW3"/>
    <dbReference type="OMA" id="KCANARQ"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="57500" checksum="C7BA825AED4364E9" modified="2008-01-15" version="1">MPPSLADEFFDQICLHSPWALTKDVFSQYFLPSVGTASQLPRVRTRLFFPASLPLFSQDVKCAPLMLATLAGSLALAADAYALTWQIRSLELHGLTRLPSSSIMRLLKAPANFQQAWRLHRVSLPGCLAVDDATISTLAQATGPTLQYLDITLTSITAHSLVVLGEACSSLSTLRLAWCEQLTEESTSHAVSEAIAKCANARQPRIPFQNLQNLDVSHTPIGDVGVSGLLRLCSGQLTSLDVSYTHVAESGTLDVLEMSLQLGGAKSLSKVLHLGLSGLCVHAVSLVAFLHAWLAYPVSEEHPNTGDAGQLCSLLLDDMVEYSRREPSSLQGRRGLSGDTLHVIAQIIADACKTQKRVFERVHMNGDKRSAYVPSHWSLPEDVLRRYKRCTSHAAVHMLMRSTRRLALGGLDLSSFAFLDYGTCNGELILPTSSTALKELSLPATSLTDDVLQHFLVPLTGALESVNLDHTQVTPTSVNALVAVNPYLCLLSLSQCRGIPVRDRRAYWDRHASTSECASPLTWSPVSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUX8</accession>
    <name>A8PUX8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732202.1">
        <property type="nucleotide sequence ID" value="XM_001732150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUX8"/>
    <dbReference type="STRING" id="425265.A8PUX8"/>
    <dbReference type="GeneID" id="5856508"/>
    <dbReference type="KEGG" id="mgl:MGL_0795"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0795"/>
    <dbReference type="InParanoid" id="A8PUX8"/>
    <dbReference type="OMA" id="KRDIACT"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="211" mass="24281" checksum="7AD8748332318190" modified="2008-01-15" version="1">MLSHNLFDRASKAVQQCLAANVFPSALIKIIKRDIACTLPSLRLFDEKSGPLWQDLFDVLLAFVFVRADEAAQREKMELINIEELQNTYSLYVPGLANLAALLIMNLPTHQTLIVLLNLIAKKSWLRAIYGLQCRVDSDDHNCNTFAIQLQGYERVFNALLAERMPHIYANLHKASVRPDEYVREWIRTLFVPWVEIDTAAHLWDIMYVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV07</accession>
    <name>A8PV07_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0812</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP45005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732219.1">
        <property type="nucleotide sequence ID" value="XM_001732167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV07"/>
    <dbReference type="STRING" id="425265.A8PV07"/>
    <dbReference type="GeneID" id="5856525"/>
    <dbReference type="KEGG" id="mgl:MGL_0812"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0812"/>
    <dbReference type="InParanoid" id="A8PV07"/>
    <dbReference type="OMA" id="HAERFFH"/>
    <dbReference type="OrthoDB" id="3363896at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="582" mass="64354" checksum="FB0AA13CAF743C34" modified="2008-01-15" version="1">MARDAQLRKCTPSSRPTSEFAFFQLQLVTYSILSSCGFQSSSANACHVLAEIVHRYLSLLAQKSVHMAHNACREKSNIIDIYMALEEIMGHGSLDELLEWADDEGIWKRSAAEVWPSTLRREQVRLDDHVFFDPTQKFPNLCYERVDDDVVCAELTVRRAVDECLEDDLVSGPGMYLAGSKRSLTTDNDPEISPRLDYNSYIPPFLPHLPTKDVWDGRAKPVIPVSNRPTKPKVGGPARPMPRAASVEGVPAADEVGNDGTRKVWQRRAMAYAGVLAEGAGTRSELPSIEICAKRRGSQAKVASKTPSTSSLDAFMHAMDAMADDPTTRTPMLLTSLARSHHANPTSTTSMAAAFKRRRIAHCMADPLRYVPNDSMHGCVHVHPTSPSCAPGPNLLITIPPPKDGVDEDTHAATAAPVFTPVHPHGRAVALAPPAGSQFPTLSYRHASHLYYAARMLMYPDMQRVFSRLSDPPSILDDHATEQVYHGTTASRAVLAGTVMSVRHRDTLSVMVSRYRGANSILHGSLERLRFHLAAELEAQRRAAQEEGRADEVEEPIRGERIKMPIKGTLVHSWDWRKADPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVE6</accession>
    <name>A8PVE6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731573.1">
        <property type="nucleotide sequence ID" value="XM_001731521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVE6"/>
    <dbReference type="FunCoup" id="A8PVE6">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVE6"/>
    <dbReference type="GeneID" id="5855879"/>
    <dbReference type="KEGG" id="mgl:MGL_0841"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0841"/>
    <dbReference type="InParanoid" id="A8PVE6"/>
    <dbReference type="OMA" id="HAMTVSV"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="273"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="3">
        <location>
            <begin position="590"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="85622" checksum="C59A54EBC2AEED5D" modified="2008-01-15" version="1">MSLGIQIAIDRGGTFTDCLGRIPASGDRPERDIVIKLLSRDPNNYRDAPTEGIRRILEMASGRSIPRSEKISTQDIAYIRLSTTVATNALLERDGQRHALITTRGFRDIVQIGNQSRPAIFDLAIHKPEVLYDQVVEVDERVTVVGYSSDPHAREHSVQFSSMGRDARITKPYTGKDKLPSASPLNMPYKEPDIVRGISGEAVAILQKPDEARVRQDLERLYAEGYRSLAVVFMFSYTYPEHEQLVKRIAQEIGFPSISCSAELMPMIKMVPRATSATADAYLTPVLQAYIDGFFSGFDSSLRDGRAGTRVEFMMSDGGLTSVEHFSGLKSIISGPAGGVVGMALTTYDKDDGRPCIGFDMGGTSTDVSRYAGKYEQVMETTIDGVTIQSPQLDVNTVASGGSSRLFFRNGLFVVGPESASAHPGPTCYRKGGPLAITDANLVTGRLAMEMFPRIFGPDENEGLDVDASTRAFEELTERINRETGRTMSVDEVAQGFIRVANEAMCRPIRSLTQARGYSTSKHVLACFGGAGGQHACSIARALGITTVVVHKYSSILSAYGMALADRVFEVQEPCNETWETTSSFDTSTALGRIHTRAQNLTKHAEDELHRQGFARDRIHTDTYLHMRYDGTDTALMTLKPADTWDMESVFVNNYRQEFGFVLADRAILVDDIRVRAVGRTFDSLGPSVLAEHATQCAKSETPFPKAKALDTASFRPVYFDGQGRVRTAIVRLRNLAIFESVPGPAILIDETQTILVEPRCEAYILSQAVLIRVQYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVJ4</accession>
    <name>A8PVJ4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731619.1">
        <property type="nucleotide sequence ID" value="XM_001731567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVJ4"/>
    <dbReference type="FunCoup" id="A8PVJ4">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="GeneID" id="5855925"/>
    <dbReference type="KEGG" id="mgl:MGL_0887"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0887"/>
    <dbReference type="InParanoid" id="A8PVJ4"/>
    <dbReference type="OMA" id="TWGFYDF"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="9">
        <location>
            <begin position="136"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="492"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="528" mass="60639" checksum="610F84F4952F5296" modified="2008-01-15" version="1">MSSIVYEISELSRIGKISSEFGLTGSRLYTCTYEAQSEQLCTENELGTYLIDGDQPTKTIHQEKFNFGEGLDKNKVMVRALFLHQSYKVNTTGYYCVDVAPFVTVNDLAEMPDKLFRGHVEFINRYRGQLPASEHPKLYFYGWLMLVYMVLCAVWLYMCYVHKDQIVTVQHFITGTIVFLMIEMACEWASYHYFNQHSIDYMFFRSVDGQASVTGMARFWLTLTNVLGAARDSLSFFLLLIVSMGYGVVRPTIGPVIYKVYLLTVLHFVFGVMYSVGVILVLLDITSGWVAFFIFPLAFTLTAFYMWILHSLKATIRYLSERRQTFKCAMFQRLNGILLGAVAFLTLYFFGMILLVSVSGPNTFAYHSWKYRWFILDGALTLLYLIVFGLIAWSWRPTGHNMRLAMSDELATDEEAPGAEFEIHTIGSDHEDMDADAREVGSEHLQGLSQAQSETGVPREYNEFESNGRIALRNKEEDDGDDNSDQFDVVFEANKEDEDLSRKSYDIESRHGHEKRRLQLNDDYEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVM2</accession>
    <name>A8PVM2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731638.1">
        <property type="nucleotide sequence ID" value="XM_001731586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVM2"/>
    <dbReference type="STRING" id="425265.A8PVM2"/>
    <dbReference type="GeneID" id="5855944"/>
    <dbReference type="KEGG" id="mgl:MGL_0906"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0906"/>
    <dbReference type="InParanoid" id="A8PVM2"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="389" mass="43765" checksum="682539C9C749F5D9" modified="2008-01-15" version="1">MTSSGNSQRGKQKPAIDLSEEGAGFPKDSTRHASFSQMCTSPRRTESSDSLAQIRRSDSMASLRALAHLIDGRSGYYEEARVSEEDLAQITHAGVRRFYEQQNELLDGWREVDEVLESQFPTEVMRRFSTPGITSRVHDHRNDSPGQHRNIDDLEEGCVTDDEGEPLWSHAFSHHPVRRGRRISERALTSLSGMLAKERHLLRGNSSVELAAESLQDLSTSAMLSQSYREHKSLADLLEHPEMERRQRESSMLQGAKESRPKTPKRNKSLLRRMLQENPAVDPSHKSYGTLDESSQLSKTESEEAPTSRQKTGDASSTSPELTAKKPTSDRSSNMVVWTKADHERDQLLQNVPTHQRKQDSDAVVQFYINSTCEQGSLKGTNVYPQSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVS2</accession>
    <name>A8PVS2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731674.1">
        <property type="nucleotide sequence ID" value="XM_001731622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVS2"/>
    <dbReference type="FunCoup" id="A8PVS2">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVS2"/>
    <dbReference type="GeneID" id="5855979"/>
    <dbReference type="KEGG" id="mgl:MGL_0942"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0942"/>
    <dbReference type="InParanoid" id="A8PVS2"/>
    <dbReference type="OMA" id="MNQPERY"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="159" mass="17196" checksum="A7974CBD29AE6E50" modified="2008-01-15" version="1">MANAPDRFTLFLLQPGEQRIEVQEDMRIPNAATFIFNKEDHTLGNMLRHAVLAQPGVLFCGYKVPHPLEPRVLVKIQTDGSLTPAEVLQQACTKLIVQMGALKQGWTKEVRLSADGGQYGSGAYGSHLWNAYGAGTQADTYSTDADRAAGGAIGGYVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW53</accession>
    <name>A8PW53_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chorein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731760.1">
        <property type="nucleotide sequence ID" value="XM_001731708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW53"/>
    <dbReference type="STRING" id="425265.A8PW53"/>
    <dbReference type="GeneID" id="5856065"/>
    <dbReference type="KEGG" id="mgl:MGL_1028"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1028"/>
    <dbReference type="InParanoid" id="A8PW53"/>
    <dbReference type="OMA" id="FHMERLC"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="849"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="894"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1050" mass="119216" checksum="38210A58B5257D40" modified="2008-01-15" version="1">MLEGVLASVLNRFLASYVDGLNTNQLNVAIWSGDVKLRNLRLKRSALDKLRLPIDVKEGYLGQLTLTIPWSNIKGKSVRMLIENVSLLAVPRDASVPVDEAEEDERQQALKQQKLIQSELLYSGALEKTEEDAQKTESFMSSLFTRIVDNVQVTVRNIHIRYEDALSSPEHPFSLGITLAELSAVSTDGNWEPTFVHNSASGIHKLARLDSLSIYWDAGTEFLTTISSEDLQQKLNELIASKDHVPEHQYVLQPVSGVGKFVMRRRATKEHAKMDAQLVFDQIGLTLSDEQYSDALSMLNLFSFYARQAQYQSFRPTAEELETNRPLAMFRFAARAIVNEMHQRRRVWTWEYMRERRDLRREYVLLFKEKELAEQQTAEGQLIPTTGRLRELENKLDLRDIRFFRSIARRQLRKERLEAAQDAEALHAPPKPASSSRGWLGWMWGSGASDAKDASPVLNKAQRKELFDAIEWDEKTGQSLRAPFEELPPDVVNLHVTAKLNRGLLALKDHRAGQPVMSLMFDNLQGEMSQRPHNFDTSVTLGALRVEDGTNDESQFREIVRVKDRGDDDDSSMPLLYMRFEHNPLDGRADNALQLRTRSLEIVYHASYLESIMHFFKPPESELELIGALLDVASSTLEGLRRETRAGLENALENHKTIDLVLDIQSPIWVIPEDVTTRDGRLLMLDAGHLAMRSLLAEPQTMDMIRAKHFRQYTEEDFRQLEELMYDRYILKLDDVQLVLGDGYEACMHSLQMRDERELHLLERINLSFTLHNSILPRAPNLTKFKVTGTLPSLRVHFSDNKYRALLQLIQVAIPSTESSSTSRSEATAFVFVPQESARLLGEVSEAAPPDMLRVPSDAAPSGQTATRAATQVFNPLQARRERLAEQMRGDADQLLLTDDDSSASSDDSRSEHDAETYEESQITDSSELLTAQQKTFEFDLVVDEVSGTVSKSGATTKEDQLLAEAVFQHFRLGVYVTKHKLQVDVHLGSLDLVDCVVEQAPMFRHMITSRPLESTTGRAEKPEADAHDLIFVQYTHVSPTAPDFHERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW72</accession>
    <name>A8PW72_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731771.1">
        <property type="nucleotide sequence ID" value="XM_001731719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW72"/>
    <dbReference type="FunCoup" id="A8PW72">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW72"/>
    <dbReference type="GeneID" id="5856076"/>
    <dbReference type="KEGG" id="mgl:MGL_1039"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1039"/>
    <dbReference type="InParanoid" id="A8PW72"/>
    <dbReference type="OMA" id="GHAAVEC"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="170" mass="18845" checksum="09F1D4B13BF7C082" modified="2008-01-15" version="1">MHTVLIAVFATGIAVGYFSHWWQSARTHNTDEELSDLEIESTDELEDSSLPIVEECKMVLGVRMDLKMDKGKIAAQCGHATLASYKTALRMHPDYVRTWSKLGQTKIAIKVPDEEQLTQLHESARRLGVPAYVIQDAGRTQVAPGSRTVIGIGPAPISKIDQLTRSFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW74</accession>
    <name>A8PW74_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731772.1">
        <property type="nucleotide sequence ID" value="XM_001731720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW74"/>
    <dbReference type="STRING" id="425265.A8PW74"/>
    <dbReference type="GeneID" id="5856077"/>
    <dbReference type="KEGG" id="mgl:MGL_1040"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1040"/>
    <dbReference type="InParanoid" id="A8PW74"/>
    <dbReference type="OMA" id="MSDEHTL"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="154" mass="17294" checksum="EA078F8CEF66949D" modified="2008-01-15" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWC2</accession>
    <name>A8PWC2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731799.1">
        <property type="nucleotide sequence ID" value="XM_001731747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWC2"/>
    <dbReference type="STRING" id="425265.A8PWC2"/>
    <dbReference type="GeneID" id="5856104"/>
    <dbReference type="KEGG" id="mgl:MGL_1067"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1067"/>
    <dbReference type="InParanoid" id="A8PWC2"/>
    <dbReference type="OMA" id="EWFEDPY"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16014">
        <property type="entry name" value="PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727101" description="Phospholipase C" evidence="2">
        <location>
            <begin position="19"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="72354" checksum="F796663441E488FB" modified="2008-01-15" version="1">MLASLALAIFALGSSAFAADEYSLKDIRHIVLFMQENRAFDHYFGSMAGVRGFQDPNAHISNNTGKDVFHQPVKASALASYSRPKNNETELLPWHLNWQGGDWYNRTQCMVAGSNSWQANHAAWNNGQIDQWVNKNTPYSIGYYRREDVPVHFALAESFIVGDAYYESALASTYPNRAIHLSGSLNANGSVVGGQPDKLGGPVVDNTNTPGCQFSDNGKPYSCRPLTWKTVPEYLQEANITFRAYQDFDNFDEDLLFAWSQYQKSAQEKTDLAKHGMSFPGLHKFFEDAENGNLPEISYIFVPAHLSEHPPYMPQDGAWLHRKVLESLMKSKSWNNTALVVSYDETGGWGDHVLGPLAPRDEPGEWMEDPFHSKLGWQPTGPGFRVPFYIASPFTRKGGVFTEHAAHESQTLFMEEWAKVHGKPFHVKEMNPWRRKHMSNLVNAFDFSKIDSSKPDIPSVPHPHKDPIRDQYNGAFVCQLKYRNKILPEIPYGQQKEEDALKVERGYKPVRGNLSEGRFLRFESDGHALTFQDGNKLTTKKSNDKYDKNALFVLHWQGSNPSENRFQISNRDKSKFVTSDLRLSGNDQAADFAVQDNGNGKGHTIIERQSKKHLSIDSDGNLSLKDDDKPTKFRTFSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWJ8</accession>
    <name>A8PWJ8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731857.1">
        <property type="nucleotide sequence ID" value="XM_001731805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWJ8"/>
    <dbReference type="FunCoup" id="A8PWJ8">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWJ8"/>
    <dbReference type="GeneID" id="5856162"/>
    <dbReference type="KEGG" id="mgl:MGL_1125"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1125"/>
    <dbReference type="InParanoid" id="A8PWJ8"/>
    <dbReference type="OMA" id="HDDVRWF"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="6">
        <location>
            <begin position="405"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="697" mass="78703" checksum="6AE9EA658A2F3156" modified="2008-01-15" version="1">MAVGVPREAPASTAPLERVKKLQLQIASSTDLNPLAHLIKEARTLHSKLTQGNADDPKSLVKALTLAARVVSHSLVGLSEKDKINFEHVDEHGRLVLQEASDPSDAQAQVSRWLQSQWNGFIMLLLDELLFSEFSAVQHSALQIVMTLQTAASESLNRQSSTKTGRWSQSPFRPLIQTLVWKRVSEDVVDIFVEEFLEVYDDVRFFFCKEISRLLRHVPDASPPHAHVRSHARTLLCRLTAIPTEPSHLNHFLVRHLSNGPKKSKKIKKQKPTMSQDGDEDDDGVIEPQPWSSESEEDQVDEDPSSHYVSMRKKRRTRHGPPVLDSLHTLSSQRQAFAAAWLSLLLPRTHSNSNGHLIVHGGNLSTSETHDILVRLHAQILPHLPNPTMLHDFLVDCLDTKGTTALLALNGLFTLIVHHNLDYPAFYTRLYALLDASVLHTRYRSRFMRMLDTFLASMLLPVAIVASFVKRLSRLSLRATPAALIEIIPFIWNLLKRHPSCMQMIHREWQHDHLALGPSAVQDPFDPYEPNPLHTRALESSLWEISTFGAYRLSQTSQHGKESTAGGDTHYLGSVSTFASILAEPFTQQRYELEDFLDSTYSTLFETETKKTLKRRQPMNKPVAPPPVAPLDIRLAVPPLLAEKTGDLDAAVRRETRKRLRLYAFPTESAAQQGDTPLEQDRRAMPLDDCARLWHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWN6</accession>
    <name>A8PWN6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_1163</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731895.1">
        <property type="nucleotide sequence ID" value="XM_001731843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWN6"/>
    <dbReference type="FunCoup" id="A8PWN6">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWN6"/>
    <dbReference type="GeneID" id="5856200"/>
    <dbReference type="KEGG" id="mgl:MGL_1163"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1163"/>
    <dbReference type="InParanoid" id="A8PWN6"/>
    <dbReference type="OMA" id="WIQDRAN"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000009">
        <property type="entry name" value="Phosphoglucomutase, cytoplasmic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="15"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="186"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="314"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP44681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="553" mass="59681" checksum="7885313442D9A075" modified="2008-01-15" version="1">MAGQQIIATKPFEGQKPGTSGLRKRVNVFQQEHYTENFVQCILSAIPSGAKGATLVVGGDGRFFSQPAVQKIVRLAAGNGVAKLIIGQNGILSTPAASHVIRLRKATGGILLTASHNPGGPEADFGIKYNMENGGPAPEAVTNRIYDLSTKIDHYVVEAGHDVDLSQIGTTSFGSLEIEIIDSVKDYVEYLGQIFDFGLIKSFLSTGSFKVRFDALHGVTGPYAHALFIDAFGLPESSVQNCVPLPDFGGGHPDPNLTYAKSLVQAVETEGLDFGAASDGDGDRNMILGKGAFVNPSDSVAIISDWAERAIPYFRSGVRGLARSMPTSGAVDRVAKAHGYEFFEVPTGWKFFGNLMDAGRLSICGEESFGTGSDHIREKDGLWAVVAWLSILAYANKERPGTSVSDVLQAHYHKYGRNFFSRYDYEEVDSAGANAMMNDLRSKFTDPNFIGTSLGAFKAAQAGDFSYTDPIDHSVSKNQGLYVRMEDGSRIVFRLSGTGSAGATIRLYVEKYTSVEREYATDVQQALKPIIQVALDLSALQRHTGREQPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWX8</accession>
    <name>A8PWX8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731986.1">
        <property type="nucleotide sequence ID" value="XM_001731934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWX8"/>
    <dbReference type="STRING" id="425265.A8PWX8"/>
    <dbReference type="GeneID" id="5856291"/>
    <dbReference type="KEGG" id="mgl:MGL_1254"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1254"/>
    <dbReference type="InParanoid" id="A8PWX8"/>
    <dbReference type="OMA" id="LFITSIN"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="75"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="316" mass="34570" checksum="29ED1D66B101F7D7" modified="2008-01-15" version="1">MTVLESWVNSFRHAPEQYTADTSYADSIDTHMAGKPEVFEKEKHENAKQFYETDDHSVMAMPGKSALKRTLDSRHVQFIALGGGIGTGLFIGSASELANGGPASLILNFFIMGFMLICVVFSLGELASVLPVSGAHSAYATRFIDPAWGFAMGYNYFLQWLVTAPIEFTAASIMIQFWDTKEVVPRGVWIAIFFIVLLVINLFGVRGYAEFEFIATLIKVITVIGLIIVMICIDCGGTPSNKYLGAATWHNPGAFNNSFKGFCASFAGVAFAFAGSELVGLAAAETRNHARCCPRLVSKSCCALFCSTSFRFFWCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX32</accession>
    <name>A8PX32_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732040.1">
        <property type="nucleotide sequence ID" value="XM_001731988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX32"/>
    <dbReference type="STRING" id="425265.A8PX32"/>
    <dbReference type="GeneID" id="5856345"/>
    <dbReference type="KEGG" id="mgl:MGL_1308"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1308"/>
    <dbReference type="InParanoid" id="A8PX32"/>
    <dbReference type="OMA" id="KATWYSA"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF25">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725024" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14550" checksum="90583EA0690A81BF" modified="2008-01-15" version="1">MQFSFLAFVATLVTFVIAAPATQLESRNIFGGKATWYSAKMSEGNCGWWSTDADHIVALNTHQYGSTDTRSKHCGRLIRIVNEKNKKVIHAVVADSCPSCEPNSLDLSKGLFSLLADGDMDSGIFPISWSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX71</accession>
    <name>A8PX71_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase M16 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1347</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731164.1">
        <property type="nucleotide sequence ID" value="XM_001731112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX71"/>
    <dbReference type="FunCoup" id="A8PX71">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX71"/>
    <dbReference type="MEROPS" id="M16.020"/>
    <dbReference type="GeneID" id="5855471"/>
    <dbReference type="KEGG" id="mgl:MGL_1347"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1347"/>
    <dbReference type="InParanoid" id="A8PX71"/>
    <dbReference type="OMA" id="WIFDEMK"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="65"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="227"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="411"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="801"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1110" mass="126001" checksum="759DCBAD4B42CE3B" modified="2008-01-15" version="1">MTSSPPGAGLARSSNTGTSGFVKHHIKLDGGKQITYEAFEGSMEKPLIDKREYKLIRLENGLEALLIHDPEADKASAAMDVRVGHLSDPEGLYGMAHFCEHLLFMGTKKYPRENEYSEYLSNHSGSSNAFTSLENTNYFFDVGYAHFEGALDRFAQFFLEPLFDPSCSEREIRAVDSEHKKNLQSDLWRSFQLDKTLSNPSHPYSKFGTGNLATLWEKPREMGLDIRDELLKFHERYYSANMMKLVVLGRESTAKLTEWVAEKFSNVPNKQCDVPSFPGSPLSDRELGTQVLFRTIKDVRLLDITFPFPEQADLYRSKPGQLLSHLIGHEGHGSLFSCLKQRGWANLLSAGSAIHAKGFELFKINIDLTHEGYEHYGDVVAAVFQYIDMLRAKPIEQWLYEEVQRLSELRFIFKEKSSPAMYSSTLASQMQHSLPPEWLLSGPYVLREFDAPLISSTLEYLRPDRCRLMLAGREPPAGVSLDKSETWYGTEYTIKPFVPEMLNSCETLQGLSMPRENEFIPHNLEVLREPNGDIPPSNRPQLLEHTPKARLWHKQDDRFFLPKANVAMLLRTPYVNASPRHAVLSRLLVELTKDALCEYSYDADVAGLHYDVDSHLDGVDIVVGGYNDKLAHLLESVLNTLTKLQVDEKRFAIVHDQVRRNYENFDLEEPFQHAAYYSTYLVTERMWTQHEKLRVVNDVTAQDVQKYISELFQQMHVEMLVHGNLTRDDARRLLETAQRHLQYEALDTHHTTPPRSLVLSPGSRVSWRVPVANKSNVNSSLEYYCQVGDPSEVRLRATLALLAQIASEPCFDQLRTKEQLGYLVFSGVRTSIGQMGFRVIVQSERDSDYLESRIDAFFDQLLHQLHEMSTDEFLAHRNSLIHKRLESVKNLAEETNRYWQSIHSGYYDFMNRQRDAQVLEHLTKNDVIALMEHYIHPSSPRRAKTVTHLQALPGDEANTAQSTTPLSKEALDAFLHVLDSHGVSIPPEARDALAVQMTSVESLQAFVKEACASGELPPSLSESALCEEIDRSAKAHPKQALNLASDLASAPQDVLTPEEVRDVHAFKKSLTPSAEAKPVLPWDVYQQEPHDPVDDSLYSSSAPVDVHANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXM9</accession>
    <name>A8PXM9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1484</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731301.1">
        <property type="nucleotide sequence ID" value="XM_001731249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXM9"/>
    <dbReference type="STRING" id="425265.A8PXM9"/>
    <dbReference type="GeneID" id="5855608"/>
    <dbReference type="KEGG" id="mgl:MGL_1484"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1484"/>
    <dbReference type="InParanoid" id="A8PXM9"/>
    <dbReference type="OMA" id="EIMFTNP"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727136" description="Tafazzin family protein" evidence="13">
        <location>
            <begin position="20"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="52"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="328" mass="37404" checksum="6EAD197F0D9DD2E6" modified="2008-01-15" version="1">MPHLSLLPIIPSVAALSRAFLTWGCKSVRVLGTDQFLHILTDPKRAEEGRGIVTYANHISVLDEPIMWGALPSSYFWDRRTVRWSLGASDIIFKNELYRWFFRQGQTLEVFRDRGIYQDAINQAIQHIGRGAWIHIFPEGKVNLTRSTYMRRFKWGISRLILEAPICPYVVPVWLMGFDQIMPHPRAPPRWVPRTGADICVVFGDPIDVDAYRQTYFEWASMHHASGLTIQRSSSSSPALGESVLDTLLALRLPRVDIHTPPHHIYTYDTWRSVQLAPEDHPAYAMIRSHLAAYLRTNLAHVGLQTRLTLGYGPGEGLLAHRPNDVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXT8</accession>
    <name>A8PXT8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731340.1">
        <property type="nucleotide sequence ID" value="XM_001731288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXT8"/>
    <dbReference type="FunCoup" id="A8PXT8">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXT8"/>
    <dbReference type="GeneID" id="5855647"/>
    <dbReference type="KEGG" id="mgl:MGL_1523"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1523"/>
    <dbReference type="InParanoid" id="A8PXT8"/>
    <dbReference type="OMA" id="NVMMKNM"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="29"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="486" mass="52350" checksum="AE10C81F3617B733" modified="2008-01-15" version="1">MVTFNTTADENIRIISDGEPLVYNLGDIAWVLTCTCLVFLMIPGVAFFYSGLLRRKNALMVLALSMMVMAVASLEWFFWGYSLTFSETATPFLGDLRHFGLMHVDMAPLSGSTKVPSLVYCMYQLMFAALTPVIACGAFADRARIGPILLFTFCWCTIVYNPLACWTWNNKGWSYTMGGLDYAGGTPVHISSGTAALAISLYLGRRHGYGTPALAYRPNNVTHVVLGTVLIWVGWFGFNGGSGIGANLRAVQAMMASHISSCVGGVTWMLLDYRLERKWSAVAFCSGAISGFVAITPASGFVGTPSSLAFGVIGATVCNFATGLKNLLGYDDALDIFAAHGIGGIAGNLLTALFADGRISTFDGTDATENMGWINHHYVQLGYQLADSCAGFGWSFVLTMILLFLIDHIPGCSFRCSEDDEIIGLDIAQVGEEAFSIPHFGHLIQQSKCVGDEAVRHADSLPEKSNVVGTNMNPAVNVHGSPYVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXY9</accession>
    <name>A8PXY9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731372.1">
        <property type="nucleotide sequence ID" value="XM_001731320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXY9"/>
    <dbReference type="FunCoup" id="A8PXY9">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXY9"/>
    <dbReference type="GeneID" id="5855679"/>
    <dbReference type="KEGG" id="mgl:MGL_1555"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1555"/>
    <dbReference type="InParanoid" id="A8PXY9"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="147" mass="16040" checksum="C9AF472D3CD913BB" modified="2008-01-15" version="1">MIARAFSPMNKAGRMMRVAGQRVRFNSNLPIPPKIATPKSVQGENAANTEAVVNFYKALPKGSEPERRATGIKAKYFDGKNASGKPLLWVIGGLMLFGYTLEYNGHLSTLARCARGLTNIAHRAPQECAPLSVFVLGFFILTYAVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY54</accession>
    <name>A8PY54_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731411.1">
        <property type="nucleotide sequence ID" value="XM_001731359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY54"/>
    <dbReference type="GeneID" id="5855718"/>
    <dbReference type="KEGG" id="mgl:MGL_1594"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1594"/>
    <dbReference type="InParanoid" id="A8PY54"/>
    <dbReference type="OMA" id="WIRPIHE"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="438" mass="48464" checksum="A5938D394A9651BB" modified="2008-01-15" version="1">MSWDFRRSRGLVGSHASLSRRHAPAPVQPGSQVWSLDNDHDDNHTAFPTAQALDGGATKGHKQPYLSTTLDRLENWLGLRSEPGPSMTRHYSPHHHQADQSHAPSGPDHSPWLSSTDMAHSSKRPGLKALSKSTMVDVMVHPVAPSDTIDRIALRYGTDSHTLRRSNRLWYGDPVQMHEQLYIPIESCRHRPADARIQAVERNADGSLHRAPSSSRTDESNPVTITKVDAEALRFFPGDRARPTRGLPAGGDMGASGVDDLIQLQQMRRERGSPMRPPEPELPKSSTRSNMTPKSAASTSAPFSTSTTDMTWQPNHRTLGQKRPLLRQVGVKDTKSTLDDDHDALLISLDQPEEPTSHGLNDLLRGPHANSGAAANWMRPIHESLPEEVPRKPSTSKHLWSDLMSGRVSIEDAFQVAVDEWRTASARSRQHHGPTLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY83</accession>
    <name>A8PY83_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase III subunit RPC6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731428.1">
        <property type="nucleotide sequence ID" value="XM_001731376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY83"/>
    <dbReference type="STRING" id="425265.A8PY83"/>
    <dbReference type="GeneID" id="5855735"/>
    <dbReference type="KEGG" id="mgl:MGL_1611"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1611"/>
    <dbReference type="InParanoid" id="A8PY83"/>
    <dbReference type="OMA" id="ELIIYNH"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57212" checksum="884CEB33BFB535B7" modified="2008-01-15" version="1">MPPKSAQDAQGLSPLEKQVHGAALAAPNKTLTGDELSRRFAQVPIEEQLLAINGLLKKNLFNAQKGPDGIQYVAVSKGEASLLGSMDSNELIIYNHIKDARNEGIWTKLIKARTNLHQTIMTRCLRTLEQKQLVKSVKSVKFPTRKIYMLYDLTPSIELSGGPWYTDNELDTGFIHELSMACLRFIQSKSWPKDGRSSALFPASHTHLFPNVHTVHRYLKQARLTDTELEPEHVAALLELLIYDQQIEKIPVLPVQASLTKRRASPSSSSSSDDDSEHSSGSDTPPRKRKHRRRKSKASDDESGNDESDDHDKESDEDVKPKRRSSRKVRIQASESTESSEDDDDSPSAKSRARRRSKSASRHRRHEDVSTDSESDQQENRRRHRRRRDRERKRRNDRNRDEESAHEPEEEDQIDTSATQVPYVYRAVKPLLEPHSSMICTTFVAPNSTQSSVCDQCNTLDFDEGVIFADPFTAADGQAEEPNIKDSGIADDNSQAPQLGWLESNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYC7</accession>
    <name>A8PYC7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_1636</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731453.1">
        <property type="nucleotide sequence ID" value="XM_001731401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYC7"/>
    <dbReference type="STRING" id="425265.A8PYC7"/>
    <dbReference type="GeneID" id="5855760"/>
    <dbReference type="KEGG" id="mgl:MGL_1636"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1636"/>
    <dbReference type="InParanoid" id="A8PYC7"/>
    <dbReference type="OMA" id="CHRTSLW"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000800">
        <property type="entry name" value="ATP-binding cassette sub-family D member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="481"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="733"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="802"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP44239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="905" mass="102574" checksum="600E03B2432CAC06" modified="2008-01-15" version="1">MAAQSRLRTTLDSAKLESINRLLAFTSLYGRNYASIQRVLRVVYLIGVACGVILMFAPKSQNKKSSKKSTANESRKESNRPDAALISPPNAQKKRVAIDRVFYARLFRLLRITFPTWRSASFGHLIGLSFTLLLRTLISLYVAELDGRIVSSLVRGDKALFLRRVVAWMCIAVPAVLTNSMISFFVNSLSLSIRSRLTNVIQNVYLKNLTFYKLTNLDDRIRNADQLLTVDVQKFSRAISLLYGNIFMPMIDSIVYNLRLSQTVGVEMLIMTTTVIRLTAMLVKILTPPFGQYAATEQQLEGEYRFSHARLLENAEEIGFYRGQELEKKLIDRSYFSLLKHMNRIFHIRIYYGMMEESIVKWLWGAIGLVICSAPVFFKIPGFVTRGIKSDAGSRTETFVTNRRLLLSTSDAFGRVMLSYKEMSELAGYTSRLTELMEVMDEINSGRAKKRLVTSVGQEAIDQKNEIFSRRGEIIEGTDEVVFEDVPIVSPNGDVLLEKLSFRIEPGNNLLIIGPNGCGKSSMFRILGGLWPVYGGRVYKPANHDFTYIPQRPYLSLGSLRDQIIYPDTVDEMHAKGIKDEDLVDILKLLQIDNIVEREGGWDAEREWRDALSGGDKQRIAMARLFYHKPKYAILDECTSAVTLEIERIMYEHATDLGITMLTVSHRPSLWKYHSHVLQYDGQGGYVFTELDADKRLKLQDEKQQLEQNLLLLPKWQERLRDLQGIKTAHERLIKSSGHGNQQKESTSQPPKQGESAKQDQTLRQESQKDGSKPEPSQQDQTSKQESKKDESKPEPSQQDQTSEKESRIEDSKLEKPKQESKQRSKDEDSRQEPPKIQNEIPAAGAKVSQPPKLKKKASKKSQNLKSPSDPAGEVPSKSPENGDDKVGKPAPAIDFASIHQHPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYF5</accession>
    <name>A8PYF5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731469.1">
        <property type="nucleotide sequence ID" value="XM_001731417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYF5"/>
    <dbReference type="FunCoup" id="A8PYF5">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYF5"/>
    <dbReference type="GeneID" id="5855776"/>
    <dbReference type="KEGG" id="mgl:MGL_1652"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1652"/>
    <dbReference type="InParanoid" id="A8PYF5"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15824" checksum="609B47BCDBCCA2AF" modified="2008-01-15" version="1">MAKPRGLYTARKQVADRRDNRWSDAHFKKRTLGNFYKTSPTGGSSQAKGIVLEKIGVEAKQPNSAIRKCVRVQLIKNGKKVSAFVPFDGCLNFVDENDEVLIEGFGRKGKAKGDIPGVRFKVVKVSGCGLAALFREKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ54</accession>
    <name>A8PZ54_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730890.1">
        <property type="nucleotide sequence ID" value="XM_001730838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ54"/>
    <dbReference type="STRING" id="425265.A8PZ54"/>
    <dbReference type="GeneID" id="5855197"/>
    <dbReference type="KEGG" id="mgl:MGL_1889"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1889"/>
    <dbReference type="InParanoid" id="A8PZ54"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="69378" checksum="DDE7694B0F19461F" modified="2008-01-15" version="1">MDTPDAHASASLFDRDNNSVVKPATIPSGSTTTPPAWSSSSWMHANRSNTYPVVSNEPQLIYNPALNNGPLKITSRLQNNDLALNVDPYGKSSGPRSSPTINAPPAQWEWGGWSHMPGRMPETMNETSVYARSSSSVPSAWTQHYRAMPPPPNSSMEVAPSVALRPSVPMASSYAIPTRKDVLANERPPQEISTLFLAGFPEDITDREFSNMFLFAKGFEASMLKYPNTNAVQQLKPDEVEARRAADKRVSGPTGLGAEKEGAGRDASDPQPSPKSKQIIGFAKFSCREEALQARDVLNGFRIDSERGCILKAELAKKNLHTKRSASYVVNKHTHPSQPNRSTALRDTHSMLTEAPLSAPILVSSQSRNVMPPSFTTPQEVLIGDPRTNSVAWSDPLDYQASNSMLGSLHHDAPSHVATTAPINEMVARLETFSKNIPTYASSGTSSLASRSESPSLAHPRMGAMDASTRSGTEPLPSPLDFRRSPSQALGPSPNEAVEQLQSLSLSGDTSGFSTKNEMNPLFTMSQSSDMISPPTQYPISSAAMPHSATSRSSVSPANSSIQSSTTGVNAYAAHAAQPAQGPSPNSHALKQDPQESVVSCDPKDSSTSSSSQVDASQTSTTTNMNKTNSGAGGLHVSTEAASPREQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZJ4</accession>
    <name>A8PZJ4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730925.1">
        <property type="nucleotide sequence ID" value="XM_001730873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZJ4"/>
    <dbReference type="FunCoup" id="A8PZJ4">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZJ4"/>
    <dbReference type="GeneID" id="5855232"/>
    <dbReference type="KEGG" id="mgl:MGL_1924"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1924"/>
    <dbReference type="InParanoid" id="A8PZJ4"/>
    <dbReference type="OMA" id="GYGLMYI"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="675"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="762"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="791" mass="86802" checksum="36523C4223835520" modified="2008-01-15" version="1">MKEKELFDEVEATHEHVRMAEEDDYEGGGVESDVDASYEGAHIPIGGRDAEDSTGRLAPHRRASPAAVPTRRAHSLASIHDPDAHTQPTQDTLPVSRRWLHTFGRRGSFHKSSRRHHSPSASSFDTTNVESIDGHSERGFGGAGGRALSVWVSQDDYAIDMRLTIKRRLMELYTSLNELKGFAELNQTGMKKILKKYDKTTGSSLKDRYMEQVVKVKYPFQPQTSKLLEERVDELVHLYARVATRDDVELAAQQLRMQLREEVVWHRNTVWREMINIERRAQAASLEKGLMGLTGGHLLNEQPELPRVIRTPFGSFVVPSFCTVGTLQLTASLVLFVALLKVPALRFFERIEVQNCFALLVLCTCLWVTEVVELFVTSLLVPFLIVTLRVAREGEGEGRRLTAPEASKWIFAQMFAPNVSLLLGGFTLAAALSKYGIDKVIATRVLQYAGTRPSVVLLAHMLVACFASMWISNVAAPVLMFSLVQPILRNLPPKSPYATSMVMGIALASNIGGQTSPIASPQNLIALQYMDKPLGWVQWFAITIPVSGTSLLVLWLLLLWSFGTGSGVHIKRIPETDNSFSRAQWFISAVCLGTIVLWCFQNQIQGMVGDMAVTAIIPLVLFFGTGVLTKEDFNNFLWTIVFLAMGGIALGKAVASSGLLKSLDSFVQNEVNGLPLWGILAILVGVGLVVATFISHTIAAVLLVPIAAQMGANLVEPHPRLLIMATTLTSSAAMGLPISGFPNMTAINLEDEVGHHYVSVKTFLRVGIPASVLATIIIATLGYVIMLLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZV4</accession>
    <name>A8PZV4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="2 7">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2 7"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730954.1">
        <property type="nucleotide sequence ID" value="XM_001730902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZV4"/>
    <dbReference type="FunCoup" id="A8PZV4">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZV4"/>
    <dbReference type="GeneID" id="5855261"/>
    <dbReference type="KEGG" id="mgl:MGL_1953"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1953"/>
    <dbReference type="InParanoid" id="A8PZV4"/>
    <dbReference type="OMA" id="SLDQHWA"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Prp19 coiled-coil region" evidence="9">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="387"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="502" mass="53302" checksum="C98E448304F36A31" modified="2008-01-15" version="1">MQDPVTGEELTREDLITLQQSPRIAFPRPPTHSSVPSLLTALQNEYDAMVYETVALRKQYDSVRQDLANALYTNDASMRVIARLMKERNDAREALASIHTSLGVPTTTSISSSSTTTTSTAPGSATQDVDMTVQGDEQVLPRSLPPAVMEQVDATASQLSSERRARIKRGASAPYPTPATASSMEEREAINAAHRASSPGILALDISANGSLVLTGGQDKSVHVVDRASGQVTAKLQGHSKPITAAVFSGRSNPAVGDAALEAPMPAFAVSASADGSVRTWRRTENDSYELAHVLETYDAPVTGVDVHPTDSLVGSASRDGSWAIHSLENGERLMHVPAPAASDDQGTGYVYESFAFHPDGQLAATGTADGAIRIWDIKQGEQSAVFRGHEGNVHTLSFSQNGYLLVAASRDASHAKVWDLRKLDVTRTIETAGSGIESVRLDASAQLLAVVGRDVRVFGGKSFELCATWDAASCTCAQWSPSDGALLVGSLDRSVRVFVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q010</accession>
    <name>A8Q010_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730970.1">
        <property type="nucleotide sequence ID" value="XM_001730918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q010"/>
    <dbReference type="STRING" id="425265.A8Q010"/>
    <dbReference type="GeneID" id="5855277"/>
    <dbReference type="KEGG" id="mgl:MGL_1969"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1969"/>
    <dbReference type="InParanoid" id="A8Q010"/>
    <dbReference type="OMA" id="WATHDEQ"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="203"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="320" mass="35643" checksum="175576A2F3949EAD" modified="2008-01-15" version="1">MWRVLIQNCHHRAWSYVDAIRGFHVSTWPSRLSRLSRARPNMNGAPHRRPMVFRIHTPSIGLAIGFVLTTSALAFTSCAAWSTHSNERLFHGSHSLYSLSSLLGVRRNSELLVQDEHAERWAGGYHRLVQYLQAFPQTVRQVGLDVYEGIADAYMALPTYQQAAVPLVALNTAVFVAWLLSPALGTSAWMQRYFVHRPSSVRVITLLTSVSSHQWFPHFLFNNIALWSVGSSAIQALPRNETHGNIPEADTFPQFLAFYISAGLFASLASHLAVAFRWRLPSLTPAERAGLSRRSSLGASGAIYAAFALCACTMPQVQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q026</accession>
    <name>A8Q026_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MGL_1974</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730975.1">
        <property type="nucleotide sequence ID" value="XM_001730923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q026"/>
    <dbReference type="FunCoup" id="A8Q026">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q026"/>
    <dbReference type="GeneID" id="5855282"/>
    <dbReference type="KEGG" id="mgl:MGL_1974"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1974"/>
    <dbReference type="InParanoid" id="A8Q026"/>
    <dbReference type="OMA" id="FPFNKFP"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="188"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="725"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="22">
        <location>
            <begin position="991"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EDP43761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1143" mass="126455" checksum="B246EC01D5B47AA6" modified="2008-01-15" version="1">MHGQHGIGDSSAASHTLRCRTSRQHLLQAGPASAIEPSANKSDTSGLERWRKFLPNNPKAQVQKVLLVGSGGLSIGQAGEFDYSGSQAIKALRESGIETVLINPNIATIQTSQQLASRIYFLPVSPDYVAYVLERERPDGVFLNFGGQSALNVGVKLDEMGVFERLGVQVLGSQPDVLRMCEDRDLFVQALDQIQIPVARSEAVSTVKEALRAADEIGYPVIVRAAYALGGLGSGFADNEEELRDLSARSLSLSPQILVEKSLRGWKESEYEVLRDQQDNALICCNMENFDPLGIHTGDSIVVAPSQTLSDDNYHMLRTAALKVIRHLGIVGECNIQYALSPDSREYRVIEVNPRLSRSSALASKATGYPLAYTAAKLALGHTLPELPNAVTKTTTACFEPSLDYIVTKIPKWDLSKFQHVNREIGSSMKSVGEVMAIGRTFEESLQKAVRQVAPNYQGFDAYVCPDDLDHALRIPTDTRLFALAHAMLVKNYDVERLHELTKIDRWFLFKLENIVNTHRELQECGSLDKVPAELMRTAKQRGFSDVQIARLVHSSEAHVRVARKAMGVTPFVKRIDTVAAEYPAQTNYLYTTYNASTHDIEFDEHGTMVLGSGVYRIGSSVEFDWCAVTCVRRLKELKHNTIMINYNPETVSTDYDEAGRLYFEELGFERVMDIYELEQASGVVVSVGGQLPQNIALRLKEAQVQVLGTDPLKIDSAEDRHKFSQILDSIGVDQPDWVEVTDVEKAKEFAKRVTYPVLVRPSYVLSGAAMNVIWDETTLEHNLTAAAQVNTDYPVVLTKFIPNAQEIDIDAVAHKGKLLVHAVSQHVENAGVHSGDATLVLPPFSLPSQDMARLKDIAERVAAAFEISGPFNMQIIRKQDPAANDESELKVIECNLRASRSFPFVSKVLGVNFIDVATSAIVGENVPEPVDLMAKTYNHVAIKVPQFSWTRLAGADPFLGVEMASTGEVASFGADIHEAYWASIASTTGFRVPLAHKGVLLGGDTTTPELRTIAMKLCNLGFKLYCSNADVETFLNGLPHVSAKRIWFPLKDKRKLREVFDDYEIQFVINLAKYRAPSVTDEDYVARRNAVDFGLPLLNEPKTALLFVETLEHKMPKGCLLPYDEGKIPSEVKAWNEFVPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q046</accession>
    <name>A8Q046_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730982.1">
        <property type="nucleotide sequence ID" value="XM_001730930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q046"/>
    <dbReference type="STRING" id="425265.A8Q046"/>
    <dbReference type="GeneID" id="5855289"/>
    <dbReference type="KEGG" id="mgl:MGL_1981"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1981"/>
    <dbReference type="InParanoid" id="A8Q046"/>
    <dbReference type="OMA" id="FRICIAG"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728018" evidence="3">
        <location>
            <begin position="20"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="408" mass="43161" checksum="1F61FD90CCC9A413" modified="2008-01-15" version="1">MFQVRTLLCAIALASVANAVVYRPNNNMVYQRRQDASATAMAQAASTSKPSPPFNFGNPSSDYPGVVADGSRGPTNPDKPMMDTPVNQTSDARLASINSADDWCTFGPLDLNLPVSDREERTVAWCTKPRNNARVIPDGTLTGVHFVKTPLYVQVMALGDFTKIGIKANDSGGELDPHGQYGGGNPKGGDVTSNVTGKDVFYKEWMNYVGHNIMCFRVCTAGSDQAKPGVECEHELDKMGCPWVMPGDYSPDVFDSCDADPAYPPGYFLEDGSTSTFQQYMTGLWTLDGKELTFTNGHKGQSTPSVAQSMPKSSNCKPVPSPANKIASLSKSAESSVSQAANAVANDGDSKSSSSDKRGDKNENNGESSGKDSDSSNKKDKNGAGSVSVTLASTVALAVGTLAAAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q054</accession>
    <name>A8Q054_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type II protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730985.1">
        <property type="nucleotide sequence ID" value="XM_001730933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q054"/>
    <dbReference type="FunCoup" id="A8Q054">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q054"/>
    <dbReference type="GeneID" id="5855292"/>
    <dbReference type="KEGG" id="mgl:MGL_1984"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1984"/>
    <dbReference type="InParanoid" id="A8Q054"/>
    <dbReference type="OMA" id="RYMAFEE"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="627" mass="71920" checksum="C433FD1AD4B214C2" modified="2008-01-15" version="1">MRGISTTCLRQVRGSLASSFLRKAFHTAPVNSKKARAPEHRVQYNYDLFSLHPEDEHYSYPLVTADDLARSKARPRSVRMLARDFIHDSLYNTHYGYFSRQAVLLPSANPPSRVGSDTASPAVTAATSSSTLDSVFPFHDIKNETEFMRAVQLRYMAFEEWFQNEMKARERRRHNNEPTPQERIDALIAKQKRTPWGSTQRLELAREIGRLQRDQSHEQVSDTEVDTMVAGQVWHTPTQLFSPHYGHALARYLVAEYKLHLFPYHDLVIYELGGGAGTLARDILDYMEEFEPDVYSRTRYHIVEISDRLAAQQKARLLHHLRQGTVEVVPRDFLQWDKDVEDPCFIVALEVLDNLAHDVVRYSTDDLQPYQGLVSIDRTGDFVELWEPVQDPLIQRYLNLFHSVRRPLLPPGAPFYLSWIPSSLRHTLHESAPFYPNLTQPHFIPTGALRMLDVLKKHFPLHRLVLSDFSSLPDTIHGVNAPVVQTRHNGIMIPVTTYCVLQGFFDIFFPTDFPLLRDIYLRHMGTSPAGDFADAGSKMSRTYFTPTYSTEFSQYVPSAYEDYSYAPSRLLGLSDVIPPPLLRDSPDARIMSHAEFLSRYADTQGTQLRDGSNPMVSWYANASWLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0F0</accession>
    <name>A8Q0F0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731024.1">
        <property type="nucleotide sequence ID" value="XM_001730972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0F0"/>
    <dbReference type="FunCoup" id="A8Q0F0">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0F0"/>
    <dbReference type="GeneID" id="5855331"/>
    <dbReference type="KEGG" id="mgl:MGL_2023"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2023"/>
    <dbReference type="InParanoid" id="A8Q0F0"/>
    <dbReference type="OMA" id="SKRDPIM"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="7">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="322" mass="35861" checksum="0618322728BF36C5" modified="2008-01-15" version="1">MVKMRRMEVASDQAYKNKLVRGFCHLSIGQEAVSVGMETAIKPDDSLITAYRCHTFVVQRGGSVSGMLAELFGREGGLSRGKGGSMHVYTPNFYGGNGIVGAQVPLGTGLAFAQKYLKTNHATFTLYGDGASNQGQVFESFNMAKLWKLPNVFICENNKYGMGTSAERSSMNTQFYTRGDVIPGIQVNAMDVLAVKRGTEFAREYTVSGNGPLLMELVTYRYGGHSLSDPGTTYRTRDEIQKMRSSSDPIQGLKTHIIEWGVMEESELKKVDKAAKEFVDKELEEAKNSPPPPEEDLYKHVYVEGTEPKFLRGRERNEIHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0G9</accession>
    <name>A8Q0G9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731032.1">
        <property type="nucleotide sequence ID" value="XM_001730980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0G9"/>
    <dbReference type="STRING" id="425265.A8Q0G9"/>
    <dbReference type="GeneID" id="5855339"/>
    <dbReference type="KEGG" id="mgl:MGL_2031"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2031"/>
    <dbReference type="InParanoid" id="A8Q0G9"/>
    <dbReference type="OMA" id="CKPSAPR"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF52">
        <property type="entry name" value="MITOCHONDRIAL CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56553" checksum="1116723BAC6BB38E" modified="2008-01-15" version="1">MMARRQGNKLGVPYLGRLLRHERPALLLSLVVPPMLANLAIGFTLFQTYTMTEHVLTTNFTDGTADTAAHPFTPTVIVAIAGAAAGAAQCVISAPLDNIRLVVQPLLIHDTGHRTTSLSLVRAPFRTWQTIMEAAVLPFLPERWYNLAIRRLERLLPTKGPGSAPTSTSSTSQSTASSALFQYLPKHVRMLARRKHGMSLILSLIRDALGFSAFFVTFEWARRCAYHASLQVDKWVHVVRRRSSPRLQNAEQQQLDQSFGASRTVFGRTTAVLTLVLGGALGAWLYSIVSRPVEYVRMVLWNRLYVPQSRRLASRGSSSRHHRTSSHYTHYRSEASSLNVRSVRVRMHVPRISFVQAERPLRTLRRRCPAVALRFSAPARPVHVNAKRMPRRKFLQSSTLSRLMRFARMTAPEGQVSSPVRLFLHTYMVRPFLYPELCKPSAPRPWGTAPPVRHAHPTSAAVPYVPTASVRRSPMRCQWIINRLLSPYACGFLVFAWMSGDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q101</accession>
    <name>A8Q101_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731107.1">
        <property type="nucleotide sequence ID" value="XM_001731055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q101"/>
    <dbReference type="STRING" id="425265.A8Q101"/>
    <dbReference type="GeneID" id="5855414"/>
    <dbReference type="KEGG" id="mgl:MGL_2106"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2106"/>
    <dbReference type="InParanoid" id="A8Q101"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="63" mass="7126" checksum="D8D784C99802B9CA" modified="2008-01-15" version="1">MGNASTRPCIKPLPHFQGIAVIDENPYEESGKNWYIPQNNFFRSVSHMIIDLTDMPTEQGTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1X4</accession>
    <name>A8Q1X4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1853</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730854.1">
        <property type="nucleotide sequence ID" value="XM_001730802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1X4"/>
    <dbReference type="FunCoup" id="A8Q1X4">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1X4"/>
    <dbReference type="GeneID" id="5855161"/>
    <dbReference type="KEGG" id="mgl:MGL_1853"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1853"/>
    <dbReference type="InParanoid" id="A8Q1X4"/>
    <dbReference type="OMA" id="KSMMATT"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="174"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="391" mass="43384" checksum="715A8CB8211841ED" modified="2008-01-15" version="1">MPIASGSSNGKNRSARQHTSGGLEAPAPGERLMGSPAPGVLASASPLSTSMTSTDGVKTFDIDDMITRLIDAGYTSKIPKPALKVPEIMAICQAAREVFLSQPTLIELSPPVKIVGDTHGQYQDLLRLFEMCGFPPAANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRLNIKVWKTFIDVFNTLPIAAIVASKIFCVHGGLSPSLSSMDDIRRIERPTGVPDYGLLNDLLWSDPSDTALDWEDNERGVSYCFGKAVIQQFLGQYDFDLICRAHMVVEDGYEFWNERTLVTIFSAPNYCGEFDNFGAVMSVSEDLLCAFELLKPLDGPSLKKEMAKTKRRSLLQQQEQQHALQQGSPSIASLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q219</accession>
    <name>A8Q219_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Man1/Src1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730874.1">
        <property type="nucleotide sequence ID" value="XM_001730822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q219"/>
    <dbReference type="STRING" id="425265.A8Q219"/>
    <dbReference type="GeneID" id="5855181"/>
    <dbReference type="KEGG" id="mgl:MGL_1873"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1873"/>
    <dbReference type="InParanoid" id="A8Q219"/>
    <dbReference type="OMA" id="YILSEPW"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HeH/LEM" evidence="9">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="8">
        <location>
            <begin position="267"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="76653" checksum="DDCDC2E0A5658D20" modified="2008-01-15" version="1">MSMPFDVAPDVDASTLRVAQLRTILQAHGIMMPGHARKAALVAAFEEHVRPHLVKAESMQAVPEAAPVTPATPAMPAMPATHPSAASSALSTQPKKESTPPSMGIGTPGMRFVSQEQPGASLKASPPASMDIRFSDENPFQRPAVTPTPSRKKAQRLSTPVAKPLTPTSSAKAKSTPVSKAMSHMPHTTSPYTRTPDKVRQIAMAASHELHVPGQAIEMSDSDSADQSADGPTHGFPLLPKENQSLSITQQIRIHWRATLVRWTAWFSVLAWIWFCWQSRLEGYCLSGTQPPVPERPTNVWQALQVVVTPVCTPCPEHGVCVGGQLVACDSSDYTIEEPALAQIPLLAQLVPLGWRARRCVPDTYKLVLASELADALVDYLAHFHGQVRCGRQQAHENAPVEAPLGMYALPETEVKTLLQARTVDTVDAHTYDVLWRMVIDGLLEHAHADMQAIVQNKDARSIRHGSVVDRWLVSPRKTMPVTCRLRLYVLDWAWRHRLALLCTFLALVGTFTLSRRVQRSRIRQHVVSTHTQRVFEQLQKQVLAHMAAMEAGSSRVVPRGIPVPHLRDTILQAEPNPQVRRQLWQHVAKVVERNANVRTRQAQWHGEWQRVWEWMGVVPVERAEIRGGQQLDESRLANSEQHHNDTTTNDINSTDSADGTNHEHADHDVHTASVPHGRHARAWAAQCITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q224</accession>
    <name>A8Q224_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_1875</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730876.1">
        <property type="nucleotide sequence ID" value="XM_001730824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q224"/>
    <dbReference type="FunCoup" id="A8Q224">
        <property type="interactions" value="688"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q224"/>
    <dbReference type="GeneID" id="5855183"/>
    <dbReference type="KEGG" id="mgl:MGL_1875"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1875"/>
    <dbReference type="InParanoid" id="A8Q224"/>
    <dbReference type="OMA" id="RETEHEC"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="65"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="286"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="438"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP43662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="573" mass="65073" checksum="8F57A578485F9C99" modified="2008-01-15" version="1">MKLDATDVRYITPEEYRVLTAVEMGSKNHEVVPTTLIAQISSLRHAGISKLLSNLLKRRLVARVQNNVYDGFRLTYGGYDYLAVRALSKRKSMYAVGNQIGVGKESDIYLVSNEEGECRVLKIHRLGRISFRKIKEKRDYMGKRKSASWMYMSRLAAQKEYAFMQILHAHGFPVPTPLDQTRHTVLMSYEDAYPLRQIAALPIDQVRHLYSALMALIVRLARAGLIHGDFNEFNLLVKEIRDDEDNTEENDMIPKHQRIERADQSDAENESDFSAEDAIVEHGKGFARVVQGPPRANDDEEKKDAVDVPKTYSDEDGDEDEDEDEDISDISVDTQQVIDLGEGIRVEPVLIDFPQMVSIEHPNAAYFFERDVDCVRRFFRKRFRFESEEYPTYSQVMEAMRDEKVDRLDALTRASGFGKSSDADAILEMHLASMHIAESEAENSGVEWDEGRSDGDRTHDEDDGQVEEEDEEEEESDEDDVDDEADVTVDSVGGMGAIKKGKMESIRRKHDMQPGQVDMSYVSSRTAASRAQAQRRSFKHHGRKSQATKIGRRHGGGKAKHNKARIVADSQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q289</accession>
    <name>A8Q289_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EIPR1-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730715.1">
        <property type="nucleotide sequence ID" value="XM_001730663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q289"/>
    <dbReference type="FunCoup" id="A8Q289">
        <property type="interactions" value="682"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q289"/>
    <dbReference type="GeneID" id="5855021"/>
    <dbReference type="KEGG" id="mgl:MGL_2169"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2169"/>
    <dbReference type="InParanoid" id="A8Q289"/>
    <dbReference type="OMA" id="KIRAMPA"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="6">
        <location>
            <begin position="160"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="363" mass="40514" checksum="C81318891D5AC046" modified="2008-01-15" version="1">MSNVEIAEDEASANMAMISNEIATVNLPNTDNSTLDVKDYDEEKGEIGSYSSASTRVQVTQRINHEGEVNRARYCPQNCDLIATRAVNGLTYVFDRTKHSNQPDSDGKCRPDIVLQGQTREGYGLSWNPIRQGHILCASEDTTVCHWDLNAYQKESKNLNPVRTYHGHSAIVEDVAWHNHHEHLFASVGDDRQMLLWDTRDSNEVPKYRVEAHTGEVNAVSFSPASEYIVATGSGDKTVGLWDLRNLSTHLHSLEAHNEEILQIAWSPHHETVLCSASADRRVNVWDLSRIGEEQTAEDAEDGPSELLFVHGGHISRPTDLSWSPQDPWKIATAAEDNIVMVWQPARSIVESVEAEPDAADLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2J2</accession>
    <name>A8Q2J2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730405.1">
        <property type="nucleotide sequence ID" value="XM_001730353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2J2"/>
    <dbReference type="FunCoup" id="A8Q2J2">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2J2"/>
    <dbReference type="GeneID" id="5854707"/>
    <dbReference type="KEGG" id="mgl:MGL_2200"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2200"/>
    <dbReference type="InParanoid" id="A8Q2J2"/>
    <dbReference type="OMA" id="FHNDMKS"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="13">
        <location>
            <begin position="38"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="761"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="716"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="823" mass="92299" checksum="87515785D1CB73B2" modified="2008-01-15" version="1">MSNSAAPVGSVWKAPEAEEKAPELHVYNSLTRSKERFVPKRGRLVTWYNCGPTVYDASHMGHARNYVTQDVIRRIMRDYLGYDVNFVMNVTDIDDKIIMRARQEFLLQQFRSQHPHLTHALLDAVQAAWNHYFRETLMPLAPPAPPHEVSSDPAEAERSRGGEGGWEQVTLLARDESWRAQAAERMPKFNLWFKTLQASRDAQVAAAVALGASDSSTSQAKALIDASADVLSMYLDNTLAHTVSDPAVFRKLAAYWEAAFFHDMKRLHVEPPTILTRVSEYVPEIVQFIERILQNGFAYVDDASAESKNVWFATSQFDGSACVAGALAENQPEAREHHFYAKLAPWSKGNRELLEEGEGALAAKGKRNAADFALWKRAKPGEPAWPSPWGPGRPGWHIECSVMASKVLGSQIDIHSGGIDLMFPHHDNELAQSEAFHGCPQWINYFLHTGHLHIEGLKMSKSLKNFISIDEALARYTARQLRLAFLMHPWHAKMDFRESGMAQVRAAETSLNNFFHGVIALEREYRAKGPAYSDGQHHYGPDAQAVASALEDAQLQFRAAMCDNFDTPRGIDILLDLVSRANVYERGTTRENLHVGVLVNVAQYVAHIVRMLGLGEGPARDGDLSWGHAPRASSATDTASSTSLSLDDSALDRDEVAAPFVRVLSSFRDRVRQLARTNASSSEFLKLADTIRDMELVDLGVALEDQEDGQALFKFVPAEQLQAQRAEKERAQVEKAARKAAAAEAARIKRREQLERGRIPPQDMFRAPHTDEYRGWDEQGIPTQDQQGEALSKKRRKNLEKEYERQIKLHAEYIAAREAHEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q313</accession>
    <name>A8Q313_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_2288</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730492.1">
        <property type="nucleotide sequence ID" value="XM_001730440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q313"/>
    <dbReference type="FunCoup" id="A8Q313">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q313"/>
    <dbReference type="GeneID" id="5854799"/>
    <dbReference type="KEGG" id="mgl:MGL_2288"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2288"/>
    <dbReference type="InParanoid" id="A8Q313"/>
    <dbReference type="OMA" id="HAHETHR"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="758"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="785"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="50"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="545"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP43278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="863" mass="98747" checksum="5F9E63744DA963C7" modified="2008-01-15" version="1">MAENEGIWTDKDEDEFVEELRMELDKVYSFQKSKVSELTGRIEQVNTEVNQLLAARSEHAHKGAGDQGQGQQQQSDQEHAQARHHNQGASSSTDASTTTMQPRSGSGSGEHAHETHRDVMYQARHNAGSDDEFDSDSDETDHFEERFQDLEENLANVIADVHDLALFTKLNYTGFLKIVKKHDKQTGRLLRKEFVQHYLSTRPFYKENYDALIVKLSRMFDVVHTRGNPVKGDASAGGSQSAFVRQTTKYWVHPDNIVPLKLFILKHLPVLVFNTEKEYQPEDSAITSIYYDNEDLELYLGRLEKTEGAEAIRLRWYGGMDNKMIFVERKTHREDWTGEKSVKARFPIKEELVNAYMRGEHRMNDTFEEMRKKGKKSDKEIDSMIQLASEVQYSVLSRKLQPVMRSFYNRTAFQLPGDARVRISLDTELTLVREDNWDGKQRSGNNWRRMDIGIDYPFEQLPEGDVERFPYGVLEVKLQTQMGQEPPKWVRELVQSHLVEAVPKFSKFIHGCATLLSNRVDLVPFWLPQMDIDIRKPVSMNLALDRPHHSSSQSDHTHSSGGRNPQYEPISEDEFEGDDNEHRESRIADEQQEADNVGLSAFDPRIKEIREQREKYLIEHRKESEGAQKAASKAPTKDTTTASRSDLHVPLSRADILSPSSVFDKNYLQKFGNNISRLWQHHSSAERESGAHQGGDDEGEERVIRALQGRDEEEPRGSGSGPPAGVEYVTDFHAEPGKRVSVPIRVEPKVYFANERTFLKWLEFSVMIASIATGLLNFQRAGDTIGLITSALFTLIALFTIAYSGVLYMWRALKIRERCSSNVYSDLYGPTFICFVILAVTLINFGMRYFETSEARLFRGVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q354</accession>
    <name>A8Q354_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730518.1">
        <property type="nucleotide sequence ID" value="XM_001730466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q354"/>
    <dbReference type="STRING" id="425265.A8Q354"/>
    <dbReference type="GeneID" id="5854825"/>
    <dbReference type="KEGG" id="mgl:MGL_2314"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2314"/>
    <dbReference type="InParanoid" id="A8Q354"/>
    <dbReference type="OMA" id="YENGWQC"/>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="355" mass="40668" checksum="60B03AFE436AE36D" modified="2008-01-15" version="1">MTGNSSELVDVATRPGYCPELAGHFLPGVAKDRIILYFGKLMPATEKGLDLSYWKQMFDEYYVPTGTMRMLMMNEDTKQRQKFDIACEFLPYFFSSCATHSMRVMRMQFTEMREYACDPSHPPPPPQGSYESSFPEPCVDKHTTHIVESNHMLLMIVYENGWQCHMVGMFRALLTPYTKVQYVPAPPGVRGNADGLVARLHTNLRIQYLCFSTLAKRMYVPFDEMMGYLETREIPPKVVEQILEYGKTMKRDKDSSESSSDERPSKKIRMDSPQLSNGQDNAWHLSLPLMYSYSDRESCCEPLPQFFLPRPRLSSLRVLDGHGFPPEMVPFVNVRISGCSLSYMLTVIPHPCPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q366</accession>
    <name>A8Q366_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730526.1">
        <property type="nucleotide sequence ID" value="XM_001730474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q366"/>
    <dbReference type="STRING" id="425265.A8Q366"/>
    <dbReference type="GeneID" id="5854833"/>
    <dbReference type="KEGG" id="mgl:MGL_2322"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2322"/>
    <dbReference type="InParanoid" id="A8Q366"/>
    <dbReference type="OMA" id="MRMATFE"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="151" mass="16504" checksum="48735F39F19D233A" modified="2008-01-15" version="1">MGTFEDSGKCKGFAFIDFDSATLATKALIEPRNSRLLGRSLQLEFAGQDAVRRGASKDLLPDYVPTRRRRRSHAADSKEMDSMEDDASADANKQNDDAGADQGGTAHWDASVSRRKQSTQPRRVRPGAANASAPRQTYGIVPSEGKRTTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3F6</accession>
    <name>A8Q3F6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730588.1">
        <property type="nucleotide sequence ID" value="XM_001730536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3F6"/>
    <dbReference type="FunCoup" id="A8Q3F6">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3F6"/>
    <dbReference type="MEROPS" id="M20.005"/>
    <dbReference type="GeneID" id="5854895"/>
    <dbReference type="KEGG" id="mgl:MGL_2384"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2384"/>
    <dbReference type="InParanoid" id="A8Q3F6"/>
    <dbReference type="OMA" id="CNVKFMI"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="211"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="477" mass="52231" checksum="E2A7A71D62B82DA7" modified="2008-01-15" version="1">MSENQAKVIAYIEENQAKLIAGLAEAVEIPSVSGDASFRAEVYKMGAWLKNRLSELGCEVSSHDLGMQELDDQEVQLPPVIVGSIGKDTSKKTVLVYGHYDVQPALKSDGWKTEPFELVHDKESDRLYGRGSTDDKGPILGWLNVLEAHQALGLELPVNLRFCLEGMEESGSVGLEDFVVQNKDKLFHDVDAVCISDNYWLGTNKPCVTHGLRGIAYFKLLISGPAHDLHSGVFGGVVHEPMTDLVRIMSSLVSPQGKILVPGIEEQVAPLSDDELKVYDAMEFSISDIDNSTGSKSTISDKKSDVLMARMRNPSLSLHGIEGAFGEPGSKTVIPHKVTGKFSIRLVPNMEPSKVVEAVQKHVESEFSKLNSKNTMKLIPDHPGKPWCTDPKHWNYEAAFAATEKIYGVRPDLTREGGSIPITLTFADALQKNVLLLPMGRSDDGAHSTNEKLDLSNYIKGTQLLGTYLYEVAAVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3X2</accession>
    <name>A8Q3X2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730094.1">
        <property type="nucleotide sequence ID" value="XM_001730042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3X2"/>
    <dbReference type="FunCoup" id="A8Q3X2">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3X2"/>
    <dbReference type="GeneID" id="5854396"/>
    <dbReference type="KEGG" id="mgl:MGL_2476"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2476"/>
    <dbReference type="InParanoid" id="A8Q3X2"/>
    <dbReference type="OMA" id="ADIQHIH"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="299" mass="33201" checksum="246A0D6015F88EBF" modified="2008-01-15" version="1">MLSQRFTWAELCHSSRARWALDWIACFVLMVIFRGVLHHRTDGFHQQFSLNDASLQHPHSSQQRVPDTLLAYFSVLLPFLLVSGLSLCMKRRWACLNKAWLGLGMTIAITGCLTELGKNLVGRPRPDFLDRCQPKHGFVASHPTTHYKSSLVDYTVCSTSIHARTLADGFKSFPSGHSSMSFAGLVFLAWFLHGCGTTIIQNSACLSDSREEAAPLDEARHMEEGLPADRVHSEPPLSLSLTSLIIPLMPVMLAACISISRLMDYRHHPTDVLAGAILGTTIGTAVYFVYHRPSNSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4B1</accession>
    <name>A8Q4B1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730136.1">
        <property type="nucleotide sequence ID" value="XM_001730084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4B1"/>
    <dbReference type="STRING" id="425265.A8Q4B1"/>
    <dbReference type="GeneID" id="5854443"/>
    <dbReference type="KEGG" id="mgl:MGL_2518"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2518"/>
    <dbReference type="InParanoid" id="A8Q4B1"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="182" mass="20227" checksum="A0400C5494DC603A" modified="2008-01-15" version="1">MWTEMHQIFDHIRRDGNVRVVVLYGNGKCFTGGLDLRENVLGQLLERDVDAARRGMMFRELIERFQAAISSLEVCERPVIGVSHGYVIGLGIDILSAVDIRYTSQDARFSIREAAIGLAADIGTLQRLPKAVGNDSLARELALTARDFDAAEAKELGFVSKVFPSQQEALRTYHTTSVQEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4E3</accession>
    <name>A8Q4E3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730148.1">
        <property type="nucleotide sequence ID" value="XM_001730096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4E3"/>
    <dbReference type="STRING" id="425265.A8Q4E3"/>
    <dbReference type="GeneID" id="5854455"/>
    <dbReference type="KEGG" id="mgl:MGL_2530"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2530"/>
    <dbReference type="InParanoid" id="A8Q4E3"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="159" mass="16317" checksum="76FECD4BC0551C91" modified="2008-01-15" version="1">MVGVPDSDLISWQVRRSERAPKNTASTSQGVPRPKRPRVDKGPISAEQLRVQLEAHKALMSGATTTSAPPQLTPSTAANASSLPPPPSLPPTMPQVVRPPAVPPAPPVPPVRPTVPNPPPAPPAAVPELDCSVSITCLFSSVTAGGVDAQRISCGVAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4W1</accession>
    <name>A8Q4W1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730272.1">
        <property type="nucleotide sequence ID" value="XM_001730220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4W1"/>
    <dbReference type="STRING" id="425265.A8Q4W1"/>
    <dbReference type="GeneID" id="5854577"/>
    <dbReference type="KEGG" id="mgl:MGL_2654"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2654"/>
    <dbReference type="InParanoid" id="A8Q4W1"/>
    <dbReference type="OMA" id="LCDFATC"/>
    <dbReference type="OrthoDB" id="3359639at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="123"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="732"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="983"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="747"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="776"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1040" mass="113987" checksum="567C1514C2753D1B" modified="2008-01-15" version="1">MLGLSSKLDATDKTEPWDVRHARISASLHTSELMAAVSPLAVYTARHAAFVRVLLSQLRHRLREECRMGHELDCALALLWSTPGSQTAISPSPSRVLSIERVRGRARARLDDVLRASLHPGDFSSQCTLQHGASGMVEIVRCRLDRKLYVLKSTLKGVARREAYRFSPVYESQLLAEGHSSSDDIIWTPRLHAAFQSARSLHLLMEYFPAGDLDSLLQAAAQAGPGYPGKSERGLLQEAWVVRYAVDMVSAVGWLHSLHFVHRDIKPSNFLLDKSGRLKLCDFATCAPYAYFHELGERRVLAYYTQRPAGTCDYIAPEILLCEQTRIQREWPSPADNSASPSSRSGEWQPDTMIPGGYGPAVDWWSLGVVLYEMLFGTLPFWASQAADVYERITHHEDYFSMSEDVPCSPDLASLIRVFICTEEHRLGRRCTADVQAHRVFHNVAWDNVTELPPPFVPELQQDPDVQMSILHSPAGVGWDSLTMDTPPSFSAMFQGPLDQFPAFDSLEGQSIDASWGADLHIPSPMPPTPPTPSQLPTSSSPVPLASPSEGVPGPPPSPLSMSACTDIDTHFCAFSFVPNPDAFHAPSPKPVASPPAASTPFGKSKPTPLTPAIALSPDASSSLQRTALERAYLTRQDMHTPFRPANEQASMLAAPPHSPYPFPPPPRMKQTPRTPAAVMADTMGADSRHSGGSTWKRNVSERQAWSELMRAVERSARKPSMQRPTSLRHVFDEESPTSIPSPLAPPVALSSPSPAPPSSSSSSSHLGPNQTSASAGIALGPALGANAGPGPLHRPPPFSSPDSNASSSDSSPSSQILRSHSSLMEARRASCDDTRGDLRHKRSTRQLLLDAQVTSTPTRAARSMSLMPVGSMNEASPPRGHTLRTLRGSASVRDFRTEYMRLEEDNYVLPTPSAPAKESVAAPTRTSMDSHRMLSEYRRAPRTLRNESEDAFGRRTCLSKRPPITRRMQSTLGLSGLYRQGRQGMASVPESSTAPPPPWSTMRDTFQRLHNEQSHIEKHVSGLEKDLGNLRNRVDKMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q516</accession>
    <name>A8Q516_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730315.1">
        <property type="nucleotide sequence ID" value="XM_001730263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q516"/>
    <dbReference type="FunCoup" id="A8Q516">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q516"/>
    <dbReference type="GeneID" id="5854620"/>
    <dbReference type="KEGG" id="mgl:MGL_2697"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2697"/>
    <dbReference type="InParanoid" id="A8Q516"/>
    <dbReference type="OMA" id="PREWIRV"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="531" mass="58441" checksum="60C2313565868E5F" modified="2008-01-15" version="1">MSLEQMSALLATAPKQPKKTSLARDDGKNHDAVTSTDDPSFASKTPFSVLRTQLCLDASHMDPANELRRQFGAAAIKASEREKGGGLPSRAGSRSRENRGANLNSNMRVRTVLCTPKPTWPDLNRSFVGMSMTTDDMPGGARVCNWVHSRAYKQAQFQFAQAVSSYDTQSLVALMRVFPWHVDTLLQLSAVSRYQGDLGQAGDFLDRALFAMERSAVPTFVSGLTSSSGPPMCDFQRAENRAFWLAVHRNIDLFGRRGTWRTSLEWCKLLFALDMTDPHGILLWIDFLAIKSRQLDWFLAFIDALDAYRNANKVAVETPSSSSLDKLKSAAHDTTHGSLDWSVGLSFARALALRGTKAPSSDAALSLAIVRHPRAAILLADKLDVSVPAEVVRAYPIRGAYSSSDPAFDELLSHIYVHRSLNLWKEAANLNWFRARAAETWPVLMDLSKTTGPAIQKFAQADGTIRMGVYRHIVVADVPEALHQQLVRYLPPDVRNPPGGMDTFDPLPPQNGTRFDEIVGIAAATAESGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q542</accession>
    <name>A8Q542_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730335.1">
        <property type="nucleotide sequence ID" value="XM_001730283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q542"/>
    <dbReference type="GeneID" id="5854640"/>
    <dbReference type="KEGG" id="mgl:MGL_2717"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2717"/>
    <dbReference type="InParanoid" id="A8Q542"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="57" mass="6179" checksum="5CD82F083B61694E" modified="2008-01-15" version="1">MAKIWIWGMPATGDLKRPFKPPAGLFSGMQQQNGPQTDKASVKEAEHVAASIRAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q567</accession>
    <name>A8Q567_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730354.1">
        <property type="nucleotide sequence ID" value="XM_001730302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="5854659"/>
    <dbReference type="KEGG" id="mgl:MGL_2736"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2736"/>
    <dbReference type="InParanoid" id="A8Q567"/>
    <dbReference type="OMA" id="GHANESP"/>
    <dbReference type="OrthoDB" id="3365196at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="921"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1381" mass="148763" checksum="29F996BDD4F6AF94" modified="2008-01-15" version="1">MNVFLRPFGEDKSKVHDDADLAAARKAVMNAGLVTPKRRTKAKATEPSVRTVRTTTGLRRIVSEDAPVRRTPRKFTNMTAEAMLGEVPHAPASVFAVGGPAVQAVEFNERRDGAESGYKSSRSEIAREEAARIHARRFRRERANADAIAEREARRLAEEQEEEEEPELDVEKAKPRGKRHAAASKGKSMFIEDDAPPPLPEKDLPSIEPSRSYLPLLSTGTSSFPTSVSQGSLDHSNSKRYASQPLNYMSDYSTTKVNVPSSTKASKETKSSLAGAAERDNLTPAQFAEMAMADFSTVRTGSTLPDYLSQRPSKTLFEEKPDLKEAGTAAPISQENVDAPKHREPGQGEAEEATESSGDKEVSLLPDVSTVSDAARLKEENVAEVNRKEAELARQEAILARLEAQKAREQAEQVRREAEQIRREAEEARQAAMEAKRLEAKLLEEAKQREEARKAQEISRVEELTRIDNAKRAEETRLAEEARKQAEEARRQAEEIKRQVDEARKADEARRAEEAKKAEEIRKVELVKQQEAKKVAEAKKLEESRKADAEKKAVEAKKLEESKKAEEAKKAAEAKKAEEERSVEAKKAEEAKKVEQEKAAEAKKLEESKKAEEAKKAAEVKKVQEKAAGAKKAEDAKIAQEAKKAQDVKEDQTTRTRSTPGKSAAATSSAAAKDTAPYISPSKSSRMPEYLRVSLSSLVRKPTRSKLSEKTPDSARSPSKFSLTSARSQQSLPKVSPSMSAQTPAATNDKNTPKTIASPAETGPMPPKKDEGLTQSPTPQVSKPTSPMSAVNEPKVLKTDAVSQRAAPQTEAVSPTKDVVSKPVTSQMGAVPPKKDEEPVSPTQPIPKDTSSSAGKPEPVSSKANAVSSPAQPQRVFPKLEIVHVTPKGAPKPASSSTKVTSASNVGPGDKVPLPGTVRKSPSNLSSSMSMPSMSSLPKGEMSSRYGLFIVGDALGKPKLAEPSKKQQEEQQPQAATREPSVASASVNNKELSKSPLVKPETRESLSSGASSASKASPAIPNIELLRLQTASDKHADSKPSGSESEPPTKSAISKPSDRKPVPPVKSDDFERSDVKPVPPFNMDDKKPSESTDRAPSFTSDSKAAPAIPNIDLTKQFTVSTAASSERADGHANESPMLKASESKPVPSVSSPSKFSGPACTEEPLTFSTADSKLAPPISSADLYNLQRRETNSGETSAVPVTRSVTEADLSKSPSVPAYLSNNLVLAKPAAQSDIGEIDARKTPTADSKEAPKSPSAVPLNEESKSNNFARTSSLTETKELEKAPEPFTTSSANPAGKKARSETGTESKAPVPPVKDESPKTEVAKSRVSEAEDKKSTEDKVTESISESKEKGEKTEKASESEAPEGLLKDVKSVTSKVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q579</accession>
    <name>A8Q579_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2745</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730363.1">
        <property type="nucleotide sequence ID" value="XM_001730311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q579"/>
    <dbReference type="FunCoup" id="A8Q579">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q579"/>
    <dbReference type="GeneID" id="5854668"/>
    <dbReference type="KEGG" id="mgl:MGL_2745"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2745"/>
    <dbReference type="InParanoid" id="A8Q579"/>
    <dbReference type="OMA" id="FQMGCYG"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="57"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="509" mass="57134" checksum="ED0B1BDC05D9F131" modified="2008-01-15" version="1">MRPMGMHRFGGVAALRHQTISPQRLSRLYVPTVSADALGSLDTLESVRRLLRGGYIRQSASGTYTYLPIGLRMLKKLTAIIEDEMHQISASQLELPQLLSPALWHKTGRFEAMGSELFRLKDRRGNDMILAPTHEEEITKLVGMEIDSAKSLPVRVFQIGRKFRDEPRPRAGLLRTKEFLMKDMYSFDVSVEDARITYEDVLCAYERIFQRVFCWDQARSSETTWMRATADSGTMGGKLSHEFHVPDPAGEDTLLSCDQCSYTSNVECAKSLGRGTKQEEQGHQHGRDETVTNAARAGDRCASCTHGTLREHKAIEVGHTFLLGTRYSEALGYHVVPRHADPKRPERVPLQMGCYGIGITRVLGALAQRAAREFDAWHAATAQTSSMPLQRRRPQRVGFFWPCEIAPFRALVLPSTPQHMDIAMRLCTQLDGGLAVTWADGMQELLHVPNEDVALDDRTHQSLGSRLFDSDLMGYPIVLILGKHYDQTGEVEVRQAGQPVRYAKCHVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6B4</accession>
    <name>A8Q6B4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729924.1">
        <property type="nucleotide sequence ID" value="XM_001729872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6B4"/>
    <dbReference type="STRING" id="425265.A8Q6B4"/>
    <dbReference type="GeneID" id="5854231"/>
    <dbReference type="KEGG" id="mgl:MGL_2910"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2910"/>
    <dbReference type="InParanoid" id="A8Q6B4"/>
    <dbReference type="OMA" id="ASEVCWV"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="5">
        <location>
            <begin position="626"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="906" mass="99224" checksum="72B76BF2F0145220" modified="2008-01-15" version="1">MDHHQAAAQKRAFLSSLPSDAESVLTSLAAIDDAWWVAAAAIAAVRSGVQWLAVDAERVLNYATERTASFDQEVQGIAIEAKRRRSATVSTADLILEWLDADPHRLPRVILRRKLWHMRWLLSIPQSRSKSAHVESDLAALADIPFLEHAQNLCLAGNERGLRALIGTHATVARSLYPHRFGLLHMLLTAGGVSPERLLQLRLLPGTRLPVEDRESGAWIDALAAPTPTSLATAALWVEHPAVITALSLRGAAIHPVAPSAPPDALSDWYMGVVRELEGRLGLVDAALDLAKAGERLGLVPLRTAAEELSFLHMLVYDLHAGDAHSITTLHRARASELVSLVTSQPLPPDLVIRHLHDSVLPFLQRGTYADAHALPAFTPSEWGVYMMLVALDTQPHARVLTFIEAMMAYPHPWLSDADRARLVLAVVGTSEAVDATSLSMYSKLVHALEDGHASPLHGDEVEAAGLGDARPDKPPSSLYLVLARTLDANPYALSQRLTVVSPSLLAEGLRDFRVLVDMTVALSRAGAHSHAPRFFWADDVQAHRAHEVTSELVQHALAQRGNERHAIERVLCALAPWIGVHRPRLPVTCVRTFFRQLLLAREPVVFNEVVQALPVICPSLACHMTATQAEDLVLETARAWMDQTPTCDPLHGLLQRAREALEAMPHTTRIRNELAFLNLLARLHEYAWPSSAEPLTPRRVRAVPQKLELFARVLAYNRDAYQTRQIRSLGEACSEGSGSTDNAVRISAMLVDAAAANGDLVAACRECERLVTLVQAIDRATNVEAYDAAWRTCFQLAKNPLWTDEQTRAQVLAHALTLAPPDHMPSILAAMADLPAHAGVPSVTRRENRAGSAWARLLTRPTHDVSSRTSTTAQLLDSVTSQHAPQAARMARSFLDNLSARWLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6C5</accession>
    <name>A8Q6C5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phospholipase A-2-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729935.1">
        <property type="nucleotide sequence ID" value="XM_001729883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6C5"/>
    <dbReference type="FunCoup" id="A8Q6C5">
        <property type="interactions" value="916"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6C5"/>
    <dbReference type="GeneID" id="5854242"/>
    <dbReference type="KEGG" id="mgl:MGL_2921"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2921"/>
    <dbReference type="InParanoid" id="A8Q6C5"/>
    <dbReference type="OMA" id="DKCIYYW"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="405"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="533"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="82269" checksum="F7AFF414B137BD04" modified="2008-01-15" version="1">MRRCAKIPSDGVRGWRRVIQHSLSASPDPITMSTAPLLLSARWHGHTADVRAIASYALADGTDLILSGSRDQCARLWVRLSDGSLSDVHVLDNGSGFVNAVAFFEQDGTLYALSAGQDTLIHAFRVDAHGSSVSVSTTPQFSLLGHSSNVCSLRTYKSDYIVSGSWDSTVKVWKHWNCVATLSGHTHSVWSVLPIDDDRILSASADKTVCLWSLSSPQEPIYKYEGATQAVRDLARLNDASFVCAGNDGQLRVLPILGGTAAPRTIATLPSFVYALCCTSTEHIGESSLISCGEDRCFRVWRQNTLSQLVPIPALSVWCVCTLSNGDVACGASDGLVSIFTRDDGRAAPADVARAFADELATQSLSAPEVQGVAVKEDRAALHQPGRHEGDVCVVREGSKSSRFHWSVFKQQWIHTGIVTEGAASSSKTEFQGKLYDYVFDVDIADGVPPLKLPYNVTENTYVAASRFLEQNNLPASFLDQVVRFLEKNTQAVGLSSRDQAADAVDPYTGGSRYIPGSSNGPSPSAPAPTSLKTLPQTQYLSFSHTQLDAAHAKLRSFSTSVPGATLTDDDAQDISKLVAALGSGSGVMNVDVLSKLLHTWPVSARFPLLDLLRAAALHPCTQPFPSIVSDALVGADWDALDAPGIDAKVASANAMLALRTLANGFVTPNGPATMDALALEALATLRHPPWHILNRPGQTALATVALNYSIRAVTQPKFEQASLLLDLIADVRSFPLCRILTIAFFQDSFSARRRRMCVSSTRGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6E8</accession>
    <name>A8Q6E8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729958.1">
        <property type="nucleotide sequence ID" value="XM_001729906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6E8"/>
    <dbReference type="FunCoup" id="A8Q6E8">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6E8"/>
    <dbReference type="GeneID" id="5854265"/>
    <dbReference type="KEGG" id="mgl:MGL_2944"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2944"/>
    <dbReference type="InParanoid" id="A8Q6E8"/>
    <dbReference type="OMA" id="IHKRVIH"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="121" mass="13634" checksum="0F5256DC57A63216" modified="2008-01-15" version="1">MSYVAKDKDVDAPVAPVKLHKIRITLTSRNVKSLEKMSNDLVNRSKDKKLHVKGPVRLPTKVLTHTTRKSPCGEGSKTWDHYEMRIHKRLIDLHSPSEVVKQITSTALEPGVEVEITILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6F2</accession>
    <name>A8Q6F2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2948</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729962.1">
        <property type="nucleotide sequence ID" value="XM_001729910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6F2"/>
    <dbReference type="FunCoup" id="A8Q6F2">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6F2"/>
    <dbReference type="GeneID" id="5854269"/>
    <dbReference type="KEGG" id="mgl:MGL_2948"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2948"/>
    <dbReference type="InParanoid" id="A8Q6F2"/>
    <dbReference type="OMA" id="KCFRREV"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="16"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="251" mass="28148" checksum="77049784496A1583" modified="2008-01-15" version="1">MDQTQGVVVGSTHKYSVILPTYNERHNLPIIVFLLCRMFQMHHLNYEIVIVDDNSPDGTQEIAKQLAALYGPEHIVLRPRPGKLGLGTAYIHGLESCTGDFVIIMDADFSHHPKFIPDMITKQLQTNADIVQGTRYSGPKTGAGVYGWDLKRKLVSRGANVLATFVLDPRTTDVTGSFRLYKRSVIDNLIRQIKSKGYVFQMEILVRAKALDYKVEEVPITFCDRVYGESKLGGDEIVGYAKGVWQLFVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6N0</accession>
    <name>A8Q6N0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730027.1">
        <property type="nucleotide sequence ID" value="XM_001729975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6N0"/>
    <dbReference type="FunCoup" id="A8Q6N0">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6N0"/>
    <dbReference type="GeneID" id="5854334"/>
    <dbReference type="KEGG" id="mgl:MGL_3013"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3013"/>
    <dbReference type="InParanoid" id="A8Q6N0"/>
    <dbReference type="OMA" id="DYEDDIM"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="445" mass="49807" checksum="7AA7954DD2660320" modified="2008-01-15" version="1">MNAQLLKGLFENADATCLAFNHGRGLFAGQYLAVGRSDYYIALYDVETRGILRWFQAHVKNITSVCWSPLGRYLASSSLDWNVHIWDLRNGPAKCVRTLRFSAPVSLVRFSPCSSRTLFVVLETREAFLVHFPTWHSVESSGNTSTAPLRIPVHGAFAVTTGCFSPDARWIFAGTNKGVVVLINSQSGHVMRSEPFSVGTSMVREMHLDAQGKHMVVNLNDRTVRTFKIAFDTWGTPIHLIHTHKFQDMVGRTPWSGVGFSQDSEYVMGGAAQDTTHNVYIWDRDAGVLVKILEGPNEPLVYAQWHPVKPQVASIASSGDVYLWSTKMTEIWSAYAPGFEELEKNVEYEERENEFDLDELHEDQRQQQEEIDFVDLFANGPVPETSLPSMGVPTDLNRSFSTLAADVRRPTTSCSPDMYGDDDDQVAFLIPPLLEDYELGDGKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7B0</accession>
    <name>A8Q7B0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Asparagine synthetase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729775.1">
        <property type="nucleotide sequence ID" value="XM_001729723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7B0"/>
    <dbReference type="FunCoup" id="A8Q7B0">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7B0"/>
    <dbReference type="GeneID" id="5854081"/>
    <dbReference type="KEGG" id="mgl:MGL_3319"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3319"/>
    <dbReference type="InParanoid" id="A8Q7B0"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="274"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="351"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="468" mass="51726" checksum="7674F8A3D5C5255C" modified="2008-01-15" version="1">MCGIGFRAWRTESSRTSEAWESVLQQVRRRGMDSHDTVARDMQGLHVELFASVLCLRGAGDITSQPLKSKDERLWLVWNGQIFECENDDDALVDARVNDARVLMDRLDAPGQDILSTLMATLGLFDGPYAFVLVDNATRLILCEPHAPISDEAVLLRDFDRILSESVRCRVQGIRGSRVAILFSGGLDCTVLAALAARYVKEPMDLLNVSFENPRAIAAAYKSMTDPVDAHTFPIDPYAVPDRVTARDSCAQLAALFPACQFRLVEVNVPYAEYAAHLDIIQALMYPQATVMDLSIAAALFFASRGTGIVHNINSDTCASYTSTARVLLSGLGADELLAGYARHRQAWRHGGYDTLTQELQMDLDRIPTRNLGRDDRIFSSHNREARYPYLARSVTTFLASLPAQAKACFEQDHELGDKHLLRCLARSLGLTYAASLPKRAIQFGARSAKMDTQGAQVKGNAPLVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7B7</accession>
    <name>A8Q7B7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729777.1">
        <property type="nucleotide sequence ID" value="XM_001729725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7B7"/>
    <dbReference type="GeneID" id="5854083"/>
    <dbReference type="KEGG" id="mgl:MGL_3321"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3321"/>
    <dbReference type="InParanoid" id="A8Q7B7"/>
    <dbReference type="OMA" id="CWWHAQP"/>
    <dbReference type="OrthoDB" id="3336654at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="347" mass="38074" checksum="58C144961DF8EBA2" modified="2008-01-15" version="1">MRSRETSVPAATIDPHMASGTVHDYGACSWTALATSQAFTDALRRDVHILVHAFALTWEWLDGKDMPNPAPAVSPLRKSLRYEYGALTVFERVWTRNQWKNASDVLGSDLATRRAFSDMVIRAFLDELAPVSPPTLSTTTTTTLNAVAATFALACWWHAQPPGTHDALYVDMHAYRALLELPERARLVLDDMLTHSVVPDTPPPSADVYYTVQELVSSVPLRVTVTPTTVPRLRASTMLLPKKTTTVSERQSAADMQMPLASASSPADEISQSIIDALGIPTLGTMPRAGASSCTAQALESLTHSHWQYGLSQQQVLEAAHSWDSPLCDEDPQERMSQILAHLRNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7X0</accession>
    <name>A8Q7X0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729603.1">
        <property type="nucleotide sequence ID" value="XM_001729551.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7X0"/>
    <dbReference type="GeneID" id="5853909"/>
    <dbReference type="KEGG" id="mgl:MGL_3147"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3147"/>
    <dbReference type="InParanoid" id="A8Q7X0"/>
    <dbReference type="OMA" id="GCQHNEK"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="2">
        <location>
            <begin position="359"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="3">
        <location>
            <begin position="1374"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1534"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1559" mass="174865" checksum="CA51AE10B6DFE461" modified="2008-01-15" version="1">MDVDFLSDDPLDDIRSFNETNVCMNFVSERTVPASVQCLPYRCQTQTEYESLLEQATKNICTCIDRGIWGSTMLEWCQHIRYLFALKYPISRSLRVRMARLFYEIAVMPKLDASLTDMAATLCVHLLRPKKEISYHDLELPWRSLYDALDREVHQKYRKIGTSAVAGVLLDLAEASQRFFPSSEATAMLETMLPHFDGHDLNSVISTQALLVHFLPLSHPDAWLPTLFRLWETFKSALFDDQMLDLLARLAELHVTDPQPTTHRSDTGVFTDEQFALIMTKCLRSAGLPVSVNKTAKAALMAQSSSVRTGADATASQKTLRMKKPSDRLHSFAVIIVYSIAYDGDDANLVGGSKALTQLAQFVQATETFFHPSNWGPWQAQLSSFVQHLTWEYARRQKAEERQDCRTPVEWRLTPANRREFVKMLRTVSLLGMFSKDAVTSLSSQSSLKRMAFLQPELVLPAILQRGYNSLESLETTQRTGAVISALATTSQPLLSRTLYPAGAKHMAPILHLCLPGIDLNDPIKTMGTCMLILSASVSLIISDASMNEPDQLESESKSESEGQRRVQVDENTESTVAAEEYAARLSTADIDSWSVEFVHRVLALITALPDEGKGGKIGEKNEEAVLNMLIATCDAFCSALGEEAFGRCLEIVLDYVRTTTAANGVKVIGSLVGCFARANSEKVLAQVVPMSCKRIEHELHHGASSIRTTSTSVPRAEDTALHWHINVLSSAVMFAGPALLQYRTEILATMTQLIHACKTERAYVLHAKFVQRVLSALVNVYAAEQRCLNPREWDSDMRRHHPHRLFGRVYELEDVEITWHVPSSAEIDMALDVLTLVVGPVLDALDALLSATQHDDAWHNDVCRYLHVMRYALAGQSAMITDQSRRHLPQDHCVYDDLGDIDASACAPPLDMNTGAAVTPDDPRYAHVVAFRERVGTVLERAAEVVSHLSADHVDAVKQVVRALRTYLVPHSAHTDEVQGLSKSVGFFRTIGRRFAKQRRFPRILWIRRAMLYHVTRQRLQSVHLAHTARDRTLMMQLERLCTSHYIPVRRLAQSALESVFGMYRGTRWLCLPTLLGQLAPSASDEQVKGALYVLGMKSFLRTCARNPRFTRPVLMAMFRLQSRARPSIQKLVRGVLSELVARMSDPCVHEAYFCTDALRELAASFGSDLESGYIGTTAAKLQSSWLELVRTSNEALQSDLLAMLHAPQTHWAFAQLALRALRAVLRRDTPVRADIAERVAQLAISDDPDLRVYAQSTLVRMLYLAKLQTFSRGQDLYLECMHQPLKRQERTAASATASMTKPERAAMFHEPLTASSHLYDKDTDAWLVQPTVDTYYVVGPAPPLCATSQRTVNAMARVVSTPAWWDAFARHVSLEMDRDYMAADTTLLVKSLFQAIGPALLEHVKPVIEAHLVSERDRHKHRAAAEISGGIVRGAKHWSLASHEALHAWLDSWLARAMCECTMDSQPAWQMWVEYVFQYRDPRRMHALLTFVWSHACEALRDERRGPGQQAHAQQLLASALHALQSKAHGWDVKDAADMPQHPPEPRHNSSRPKPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q834</accession>
    <name>A8Q834_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729649.1">
        <property type="nucleotide sequence ID" value="XM_001729597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q834"/>
    <dbReference type="STRING" id="425265.A8Q834"/>
    <dbReference type="GeneID" id="5853955"/>
    <dbReference type="KEGG" id="mgl:MGL_3193"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3193"/>
    <dbReference type="InParanoid" id="A8Q834"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23280" checksum="2BCE2BCF9641D990" modified="2008-01-15" version="1">MATDRSPDISAPENADFQKVEYWDKRYASEAEDTDFDWFRKVCTNARVYSHLLSIVISTLSKDMLDDGYTNIVNLDYSSVIIEKMRARVPELDWRIMDIRELEQHASTLGGPGTWDVIVDKGTMDALMAENGSVWNPSEQVLQNVAAEVQGVLQYAYSVIVCQRTYAQLIETCHGPVPLLHIRSTTFSKAAYAARCMDDRDSRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8X2</accession>
    <name>A8Q8X2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729324.1">
        <property type="nucleotide sequence ID" value="XM_001729272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8X2"/>
    <dbReference type="STRING" id="425265.A8Q8X2"/>
    <dbReference type="GeneID" id="5853631"/>
    <dbReference type="KEGG" id="mgl:MGL_3359"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3359"/>
    <dbReference type="InParanoid" id="A8Q8X2"/>
    <dbReference type="OMA" id="TLGWGWR"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="66"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="181" mass="19482" checksum="57336D28D01628AF" modified="2008-01-15" version="1">MSLLRSAAARISSMALLAPRTSLYTPSLAHSSLVQPWRTGGSYRPISVTPLVSHGGITRPTPGTGIKVTFRDSQGNDLKTVEANEGDDILSIAHEYDIDLEGACEGSIACSTCHVILEEDVFYQLEEPCDDENDMLDLAFGLTETSRLGCQVHVTRDLDGMTVQLPAATRNMYVDGAKGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q976</accession>
    <name>A8Q976_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SigF-like NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729393.1">
        <property type="nucleotide sequence ID" value="XM_001729341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q976"/>
    <dbReference type="STRING" id="425265.A8Q976"/>
    <dbReference type="GeneID" id="5853700"/>
    <dbReference type="KEGG" id="mgl:MGL_3428"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3428"/>
    <dbReference type="InParanoid" id="A8Q976"/>
    <dbReference type="OMA" id="MSQIFTI"/>
    <dbReference type="OrthoDB" id="2344312at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057514">
        <property type="entry name" value="NTF2_SigF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24840">
        <property type="entry name" value="NTF2_SigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="SigF-like NTF2-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="181" mass="21310" checksum="AA7E4A06B837B2CF" modified="2008-01-15" version="1">MEDPRNEVHDVVYGLVRAENADKQRDVLQRYYLPSASFDHPMCSVTRSRHSRDAGVLQIYQFLRILFMDTEIKIHSSCFDEENNRVYLEATQHLRSYIPFVRKYLYDRTARLVVLLDLRKLDDGKYYVSRQQDLYSIQEEAETILPGGFDTVIVNIKAFVGHLIMLQVAFFQLLGIWTVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9B1</accession>
    <name>A8Q9B1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3448</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729413.1">
        <property type="nucleotide sequence ID" value="XM_001729361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9B1"/>
    <dbReference type="FunCoup" id="A8Q9B1">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9B1"/>
    <dbReference type="GeneID" id="5853720"/>
    <dbReference type="KEGG" id="mgl:MGL_3448"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3448"/>
    <dbReference type="InParanoid" id="A8Q9B1"/>
    <dbReference type="OMA" id="THAQDEE"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="12">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="253" mass="28809" checksum="5112D172A03166C7" modified="2008-01-15" version="1">MTRDLIDLVTESETRIAVLEELETLIQSGHVDNVSISEFCALFLVLLLIHARKNKTTSSLDCVYKERVHTRMNAYRAQTLRKRYSKHPAYIEFKSRIWEVEHEGAMPPLVDLLPAEHGDQEVDVSGIRRHDDHDADGLARGVTIDNEDDDEIVMGGTVRQFRCPITADILRDPVIHAPCQHAYSREALASYMAQAPGRHGSVRCPAAGCQHVLMRSAIHEAPSLKRRVARYERQLLRREELRREQQEATAVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9F0</accession>
    <name>A8Q9F0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729434.1">
        <property type="nucleotide sequence ID" value="XM_001729382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9F0"/>
    <dbReference type="FunCoup" id="A8Q9F0">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9F0"/>
    <dbReference type="GeneID" id="5853741"/>
    <dbReference type="KEGG" id="mgl:MGL_3469"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3469"/>
    <dbReference type="InParanoid" id="A8Q9F0"/>
    <dbReference type="OMA" id="GVFMAFH"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="158" mass="18273" checksum="E764F542911F27DB" modified="2008-01-15" version="1">MQVFVKTLTGKTITLEVESSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKTYTTPKKIKHKHRKVKMATLKYYRINDDGSVKQLRRECPSPECGPGIFMAWHHNRQYCGKCHLTYLFQEGTTKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9I4</accession>
    <name>A8Q9I4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729452.1">
        <property type="nucleotide sequence ID" value="XM_001729400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9I4"/>
    <dbReference type="FunCoup" id="A8Q9I4">
        <property type="interactions" value="638"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9I4"/>
    <dbReference type="GeneID" id="5853759"/>
    <dbReference type="KEGG" id="mgl:MGL_3487"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3487"/>
    <dbReference type="InParanoid" id="A8Q9I4"/>
    <dbReference type="OMA" id="GDCEVNQ"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="329" mass="35445" checksum="6C91CFB5F7C562A8" modified="2008-01-15" version="1">MSTWNKHYHWKTKGCTPWAKEWFTEHLVGQSKPLNDGTNASVKVDKLTGFEGDVELGNRKGKLITIYECSVTLAWSGEAGDGTKANGTIKFPEVSHENEDNDEPYLYETELLSESTGMALDLYHVVRKDLVPALQNEFHQFQKDLVESHARDLGHEDGAASSTSTTSNAAAASPAAGASNAQSTQKNASSASGAVTTSTADVRVSSHLAISEADLWDLLTNPHRIPMWSKAPAQFSPNVGANFSLFGGNISGSIVEVSAPRKLTQTWRIPQWPAGHHGTLTTELTQGDDSTKLELILSGVPTGEEDHAQAGLEAYYIRGLKSLGLGTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9N2</accession>
    <name>A8Q9N2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729480.1">
        <property type="nucleotide sequence ID" value="XM_001729428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9N2"/>
    <dbReference type="STRING" id="425265.A8Q9N2"/>
    <dbReference type="GeneID" id="5853787"/>
    <dbReference type="KEGG" id="mgl:MGL_3515"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3515"/>
    <dbReference type="InParanoid" id="A8Q9N2"/>
    <dbReference type="OMA" id="VHNEDGL"/>
    <dbReference type="OrthoDB" id="2507795at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="650" mass="70569" checksum="5D6CB806FA148523" modified="2008-01-15" version="1">MGHQADATCMTEEASEHSTPTQQTDQDDSLHAEEEIPTMRLTFQEQDFCVFPSPHDETPTVYMDTSSKDTGAEDALVGVPAPELHIDPGVFWEPLDSLFAALRVTDALGEFLEEGTELCLAFPDLELVLHEDNVYAREISLHDISQLALGFGYHGSLHVLVTETPRFISQYNALAMMMSGAADDDNEAAEDEWKDGQMDEVEAEEEDVDEDDKAEDGQVDEDESGDDDEADQADDSQVDEDDPGDDDEADQADDSQVDEDDPGDDDEADQADDSQVDEDDPGDDDEADQAEDGQVGEDDPGANDEVDQAEDGQVDEGEPDANDEADQAEDDQVDGDNVSEAGKNKMVGQTKESLHKEADDVHATYSGDEAVHREEAEDADKTTNAADENDAGSVNHDATASNVPFAETIGHAVDAETRPSNGPVRNDLESIDVEQSPSHVDDNIEETTVGHTRTGENLDANYDKHSTFENGLDHGCNARHSHDANVTDNNKACDEKPRDTLADAVVSCPIPRANDSGRAGESTNYDTSTPMSPSPSKAESVDQHRPASSPFTSVTYDDTSIRHTSSSSIEQRHHIQHTSVYDDGQLVHEHDVYSAHPSNANGSVLYDEYDQAVYEDDEPIHGASQPHSKRSAVPENGSPSVSLPKRPKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9T6</accession>
    <name>A8Q9T6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_3560</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729525.1">
        <property type="nucleotide sequence ID" value="XM_001729473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9T6"/>
    <dbReference type="FunCoup" id="A8Q9T6">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9T6"/>
    <dbReference type="GeneID" id="5853832"/>
    <dbReference type="KEGG" id="mgl:MGL_3560"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3560"/>
    <dbReference type="InParanoid" id="A8Q9T6"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="19">
        <location>
            <begin position="106"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP42311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="327" mass="36243" checksum="5D9EE646C853C2D4" modified="2008-01-15" version="1">MAQLISSCTRAVASRTSAKAGLTQSVRLPVRFASTRAQTKATSPLTSRTSAVAATAIALGSVMWYQQMYGEWPFMESLSANLSDEGLHPPAYPWEHNKWFKTFDHAAIRRGFQVYQEVCSTCHSLERIAWRNLVGVSHTVDEVKAMAQDVEYEDGPNDNGEMFQRPGKLADYMPSPYPNEEAARAGNAGALPPDLSLIVKARHGGADYIFSLLTGYCDPPAGVTVQEGLNYNPFFPGTQIAMARVLFDDLVEYEDGTPATTSQMAKDVVTFLHFAAEPEHDQRKRAGFKALILLSSLFALSVWAKRFKWAPIMTRKIVYDPPKGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA01</accession>
    <name>A8QA01_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729106.1">
        <property type="nucleotide sequence ID" value="XM_001729054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA01"/>
    <dbReference type="STRING" id="425265.A8QA01"/>
    <dbReference type="GeneID" id="5853413"/>
    <dbReference type="KEGG" id="mgl:MGL_3573"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3573"/>
    <dbReference type="InParanoid" id="A8QA01"/>
    <dbReference type="OMA" id="DVIAFMH"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="361"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="702" mass="77288" checksum="A98BAD0A0767DD15" modified="2008-01-15" version="1">MSPSMAKSALTYDDEDSPNDSTSSPASSAALSLRSLSACDNERTHQGILNQASPFRSTFQPQAHDYRALSDPAPSNSRLRPGITEQDLGSPKSRLLSSPEIPDSQLYSTSFPTVSVDAHEMPISAELASAEGPRISLRSPVPQRPLPGSRRESGSDLDTSLNDVPVRRHMGSFYLRKQSSNPDLSHSIRSIDSIIDDDCNSIGQGESRFRIGPIRFFSRFFHDDVPRGTRSGSTSPNSFSPPSSSLHPGASFRGLNDLRRSFNMGRPSSLAQTLGLSAKQALPRPPRSPMVSAIASKNLEVDDDDIHEIHGLTTRSSTPVRSLSPPTMPNQVYTSFCPEAGLAKLNIQDSHASDVQNMSAYELGEEIGSGAYGFVRRARSRDRGEEVVIKYIFKSSIFADSWRRHRIYGTIPGEIFVLLQLQHTSYTPPPSPPRYIANKSRWEQVRDTVLAEQSQGHTTGHPGICKLLEFFEDNDYYYMVMPRFGNGQDLFNYVESSPYGLEPREVRSFLGQVADVIAFMHSNGIVHRDIKDENVILDSYGMVQLIDFGGAARIRPGLMFDTFSGTMDYAALEILRGEKYSGPPQDVWAFGVLGYVLVCGECPFANVEEASVGMSAGARPLLVLQHFCLEQSPGVHSLANSDSSQDENIPPPDNGGHFSQLCDLICQCLQHDPSMRPSANDILHHAFLFGNQGWMGPCGWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAJ0</accession>
    <name>A8QAJ0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729282.1">
        <property type="nucleotide sequence ID" value="XM_001729230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAJ0"/>
    <dbReference type="STRING" id="425265.A8QAJ0"/>
    <dbReference type="GeneID" id="5853588"/>
    <dbReference type="KEGG" id="mgl:MGL_3749"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3749"/>
    <dbReference type="InParanoid" id="A8QAJ0"/>
    <dbReference type="OrthoDB" id="5511684at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="49" mass="5628" checksum="A208E3EB0289ECC2" modified="2008-01-15" version="1">MPVEVYPIVAITGLAVCGASWYLTRLARSPDVIWDKKGEFDKVYKRDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAW9</accession>
    <name>A8QAW9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729057.1">
        <property type="nucleotide sequence ID" value="XM_001729005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAW9"/>
    <dbReference type="STRING" id="425265.A8QAW9"/>
    <dbReference type="GeneID" id="5853364"/>
    <dbReference type="KEGG" id="mgl:MGL_3845"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3845"/>
    <dbReference type="InParanoid" id="A8QAW9"/>
    <dbReference type="OMA" id="IMKGSRH"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF517">
        <property type="entry name" value="RNA HELICASE NONSENSE MRNA REDUCING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="1">
        <location>
            <begin position="534"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="2">
        <location>
            <begin position="811"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1118" mass="123633" checksum="BB63F17947FB10A4" modified="2008-01-15" version="1">MIQAEQRDVDWGDRQPQVWHVPVPVPVRAAGSSGPMTSHAPRRIRASTIDALLRDWESRVSQHEHESDSGPVLDLEREIEHELDPAWIPVNEDTYTPALFAPLPDAWIDTLAEKAENDAFSYEISPHDMLLDRLTNDAAAPLIVSADNMIETDRGIEMPIVRTSHEPLTMQKHAPVTSKASSAPPPKQSVRDLFDWRTVAPSQQGVALPGHVYTHMIGERWDSETWVAKRRKPSQTLLLRTAHQAARAAGRQRQHHEPHLYPGERALLDSRSLTLAARTYQQHWRHVLAYEREHHESEVDEQRAQPIEELIAQGVALDGLMAFWQKERHFGRRLAVFKYPGSRRLPPHKFQSGTVIDVAPDAPDTPADWYLPKRARRFTGIAAAATPAAAPRSSSSSPSRAVRIPAEVLDVTSTQMRVRFSEAYERIDLSAFDSWRIDRGESNVVNERTEAALDALLYSPADVVRAMTPEKQYALAGTELRDVLTGIASWPSPMYTYDQNADGLFANDQRIRSWYERYARDDPIRMDGDPDLRLNASQLQAVAMMLKERVSLVQGPPGTGKTRTLVQTVSLLKRHFQVPHPILLAAHTNVAVDNLAEGCVKVGLRVVRAGSSTAMRASLEPVSFDAQFQQHANYRMLCAAEKNLREQQQYRDALQEQIALAKQDSAAGLRLKLRHVCQTVTKLTAKCHLVRNRMYADVLHRADVVCTTAVAAGSSQLATIDFPVVFLDESSMATEPIALIPLMKGCAQLGLVGDHKQLPPVLHSADARHAGLSMSLFERLMRRMIVGRRGKTAGNTISATAASPAAAQDMRPIPSIMLSEQFRMHPTLSSFPNRHFYDGALKDAPSTSARQPYNSVFAARNAHGEALPLTLVTHAPVPFSTGLLTRGVSPHNQPQADMVLELVCDLLERNPSLSGTEIGIVTPYEAQVRLLRKMLAAAAAAAAVASPATPPASFPWLSEDAMDFLAGVSIARAHELAAIEVHTVDGFEGREKPVMIFSTVKASGGSVEGTAALYRARTEPSDETAARLEHVANVRGGYVGFLADARRMNVALTRAQRQLFVVGNLETLLCARLGEGGAENVECQDVHVIRQYARWLLAHGYVVDMQDVRDRQLDAQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBG3</accession>
    <name>A8QBG3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728915.1">
        <property type="nucleotide sequence ID" value="XM_001728863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBG3"/>
    <dbReference type="STRING" id="425265.A8QBG3"/>
    <dbReference type="GeneID" id="5853221"/>
    <dbReference type="KEGG" id="mgl:MGL_3909"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3909"/>
    <dbReference type="InParanoid" id="A8QBG3"/>
    <dbReference type="OMA" id="FLRPPNI"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35593" checksum="2F2D6D367B47C4E6" modified="2008-01-15" version="1">MNQNRPVQLLDPPMQDHMYAGANTSMQPATEFEPMSDKFIDEPAIEESALFSDVNSMDRNPSMYLGSQRKGIWLPEDRRAFQNQNCLMQILRILLFILVFGIILALCVIMLIFIFLRPPNIGFNDDIQLPQSQQQLDISGGHFSVPANLSFVVRNPNYVPAKINNISALAYDNSEQTTSIGTCNVAHQTIHARDDTTVTLPCKLEYDLNKDSHLSILKDIASRCFKSNKKLQLLLKVHVNIQLYSFKVPFDLSPVISISCPISKNDIKKLAGDKPDIDDLINGLNSRRSQSQWLALAKRFYEPLAAPHDDRTAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBJ3</accession>
    <name>A8QBJ3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728922.1">
        <property type="nucleotide sequence ID" value="XM_001728870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBJ3"/>
    <dbReference type="STRING" id="425265.A8QBJ3"/>
    <dbReference type="GeneID" id="5853228"/>
    <dbReference type="KEGG" id="mgl:MGL_3916"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3916"/>
    <dbReference type="InParanoid" id="A8QBJ3"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10585" checksum="BFE508E7E9DD3E6D" modified="2008-01-15" version="1">MNTAGHIACDSVSQSEIVVPIVVPRTRLSSMHQAAIRGEGPEPYVRAWAGRGTENDHVIVGVLDIDCESPNGFDTEDARALQNIVHRITEACDWCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBK5</accession>
    <name>A8QBK5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3919</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728925.1">
        <property type="nucleotide sequence ID" value="XM_001728873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBK5"/>
    <dbReference type="STRING" id="425265.A8QBK5"/>
    <dbReference type="GeneID" id="5853231"/>
    <dbReference type="KEGG" id="mgl:MGL_3919"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3919"/>
    <dbReference type="InParanoid" id="A8QBK5"/>
    <dbReference type="OMA" id="GWFTLGS"/>
    <dbReference type="OrthoDB" id="4506189at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36284" checksum="0483E86F1F8BB2FD" modified="2008-01-15" version="1">MSATALDAFYRGREEPLPHMNHVPYHLERFVDAVEGMVRDEQARAANMPALHQQGAVADTTRVHEIRAAVAYADRMARDVQITPPKMHERIQHICSAADNLTGISKKPLHASPADEYWNDYLYEGLDLLSPTGVDPATAHDDSDDQRPLESDQGSDEMSTARLSQSPSEISATGTANQAPQQGSTALPSKPELRQRHKSANEGALSSSSSSSSSAGDRLSFESVRTNDSTESRAPMLQSDRSLQDALSSELLRMAGVLKANTVAFSESLERDRVLVESATGRLDQNLSLMTRTRGQLGVFSKKARSMGWFTLGSIASVIVCWVLMFIVIRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC55</accession>
    <name>A8QC55_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar ATP synthase subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728807.1">
        <property type="nucleotide sequence ID" value="XM_001728755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC55"/>
    <dbReference type="FunCoup" id="A8QC55">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QC55"/>
    <dbReference type="GeneID" id="5853196"/>
    <dbReference type="KEGG" id="mgl:MGL_3974"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3974"/>
    <dbReference type="InParanoid" id="A8QC55"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29622" checksum="6EEB36C44E670978" modified="2008-01-15" version="1">MASSGQREAVFPTRMTLGTTKTRLKGAQNGHSLLKRKADAISKRFRMITGKIQDAKKQMGTVLQHAAFSMVEVGYSTGDIGYAVRENVKRATFKVRSRQENISGVMLPSFAVQSSDGSVSSDHSKASGGKESSGPSEFSLTGLSRGGLQVHKARDTYAKALRVLVDLASLQTAFVILDEVIRLTNRRVNAIEHVIIPRLENTIAYIVSELDEMDREEFFRLKKVQGKKKRVAEEAAAKAAAEKVSITTTEATDSDHKDMLNADKDTDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCI0</accession>
    <name>A8QCI0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728844.1">
        <property type="nucleotide sequence ID" value="XM_001728792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCI0"/>
    <dbReference type="STRING" id="425265.A8QCI0"/>
    <dbReference type="GeneID" id="5853150"/>
    <dbReference type="KEGG" id="mgl:MGL_4011"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4011"/>
    <dbReference type="InParanoid" id="A8QCI0"/>
    <dbReference type="OMA" id="ICAAHER"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="337"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="521" mass="58457" checksum="3A7295F0E51BACE4" modified="2008-01-15" version="1">MAATYANDVTDQDYSPLLVEFPESPRIRYTHKYSESDDEHYGCPSDGEERLGDEIEPNCNSYSSTISKRDDDQPLADAESVDVLAAHDRIIRHEKARQNNVALMILEGKVPASNQSQLIQRSRSMPHRRKQGTRVQRAERSPKPPTYPGLQQSRPSTLEPKIHPTSSLTQANMPSSAGIATGSRRAVTAPIQTRNITDTSYDVNTPHMGWDKQMKSVQAAMAKMNIQSPSQGVAQNAMRIFLQTTQKYLVVPMHEKTVVWNALQYIFAQGGVPTSMGAHNNWAIFDVLPDLSLERPLREYERLYEVSRARGSNTGFFLVKMVDWPELLRAASIPSFSSILGGFVSIQAEDGWTRRWLELREHAIFVAKSETSKPDGCICSMLDVDIYLGDPQRNTGPKGFSFALRTQGSHATTLLLAAQSDEAAHNDWFKNIYRARSYVLCQERPDLLKAARAVERTEQKVASIRRTKSVRKQAALQRSNAAQHSRASSQSSAPLIQNDAFHMQFERGSLLDSMERSKPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCJ9</accession>
    <name>A8QCJ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Shr3 amino acid permease chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728850.1">
        <property type="nucleotide sequence ID" value="XM_001728798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCJ9"/>
    <dbReference type="FunCoup" id="A8QCJ9">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="GeneID" id="5853156"/>
    <dbReference type="KEGG" id="mgl:MGL_4017"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4017"/>
    <dbReference type="InParanoid" id="A8QCJ9"/>
    <dbReference type="OMA" id="ANMLFDG"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23378" checksum="C912B4C4F7B3A4A0" modified="2008-01-15" version="1">MGFRTGFVIASVCFTYGLLYITSTYDYPLLFQQGFTQSDVDKSVGFYLSMYQAPLSVKALVHSVFGLGLIGIVVKIVRWGEQDKYFGSVSLLLYFSSLLMYVSVEIPNMRVLAAPEEKNIVHRAVFDAEDTRKVENYEFYPLTGRERASVVQVIGATNVIITALLAGVLLMQGGEWYSTRLDRIAENKQRQEMIAKLGADRSVEKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCL5</accession>
    <name>A8QCL5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aip3p/Bud6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728855.1">
        <property type="nucleotide sequence ID" value="XM_001728803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCL5"/>
    <dbReference type="STRING" id="425265.A8QCL5"/>
    <dbReference type="GeneID" id="5853161"/>
    <dbReference type="KEGG" id="mgl:MGL_4022"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4022"/>
    <dbReference type="InParanoid" id="A8QCL5"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aip3p/Bud6 N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="84" mass="9695" checksum="B9612DBB5AF46EA0" modified="2008-01-15" version="1">MMRAHDQRSHELMQQQARTPVQTNHMESSVTRLLVATKMLLESLTQWALRKDTETNVSRIYVRLGNDFNASITAFMSAGIDMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCZ7</accession>
    <name>A8QCZ7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728730.1">
        <property type="nucleotide sequence ID" value="XM_001728678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCZ7"/>
    <dbReference type="STRING" id="425265.A8QCZ7"/>
    <dbReference type="GeneID" id="5853048"/>
    <dbReference type="KEGG" id="mgl:MGL_4065"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4065"/>
    <dbReference type="InParanoid" id="A8QCZ7"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38352" checksum="9B0340917EC7E6B5" modified="2008-01-15" version="1">MDEGASSSIPIVTADAASPQEYRILEVPPEVEALIERKDVPLQFNGRLADEAVLVTHDATYAVRQVSQSNSLLLCSVDVRDNGSHALVLRQNVQDTLELVRTCANLERIMSLLDEDMYTGGEEHVHDRTKRHYTRNELMSVVQASEAEFTQGLRAYHVLELDGYLRRVAPDLVVDLLHSLLAHVDIFACAPDRVPYVRMCEALAPRACRAVAEAMVGDWFCATPQRASAPTVPLHIPLARESVAQFLGLHLLRTQKRMPLIAFMDAWHHELGIMSQDAHLALLQVRGKWSSVSIASALTLATHLLYRDIIYYTQHRPRLLRRMPTQQRRQVHCHVRWPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD95</accession>
    <name>A8QD95_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="2">PRDH</shortName>
            <ecNumber evidence="2">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728684.1">
        <property type="nucleotide sequence ID" value="XM_001728632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD95"/>
    <dbReference type="FunCoup" id="A8QD95">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD95"/>
    <dbReference type="GeneID" id="5853024"/>
    <dbReference type="KEGG" id="mgl:MGL_4163"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4163"/>
    <dbReference type="InParanoid" id="A8QD95"/>
    <dbReference type="OMA" id="WRVNACD"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="460" mass="51399" checksum="ECB877DA6F469533" modified="2008-01-15" version="1">MTTQNEEKEHLHVGIIGMGDMGRLYATRLRAAGWVHVNVCDRPEKYESLRDELQGTGLTVLRDGHHVSRRSDFLMYSVEAGNIHKVVAEYGPSTKVGAVVSGQTSVKAPERVAFETFLPEDVYIVSCHSLHGPHVDPRGQPLILIQHRAPADKLHLVERILACLESRYVYMSYEEHDTVTANTQAVTHAAFLTMGTAWAQLQAYPWVTGKNPGGMETVKIYLCLRIYGAKWHVYAGLALLNPEASVQVTQYAASATALFQLMLEGKYDALVQRVLSARRSVFGWQDTEVGTNLPGRSRILVSDEMLDEFYVIAERVNKGEKSAAEAERTVREEAPPANSHLSLLAIVDCWHVLGIDPYRHLELAATPVFRMWIGVTQNLFRSPDRVLAACRAAVHDVHFRADDLEFVIAARGWAQAVQFGDFDAYQRRFETTRAFFMPRLSEANKVGVNMLSVLSSQSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDP1</accession>
    <name>A8QDP1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_4224</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000023">
        <property type="protein sequence ID" value="EDP41411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728625.1">
        <property type="nucleotide sequence ID" value="XM_001728573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDP1"/>
    <dbReference type="FunCoup" id="A8QDP1">
        <property type="interactions" value="466"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDP1"/>
    <dbReference type="GeneID" id="5852946"/>
    <dbReference type="KEGG" id="mgl:MGL_4224"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4224"/>
    <dbReference type="InParanoid" id="A8QDP1"/>
    <dbReference type="OMA" id="RWLKGWE"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="64"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="621" mass="68696" checksum="B71CE7E4B78426D4" modified="2008-01-15" version="1">MWVEKYRPRAFTDLMGDDRLHRETLRWLKTWDPCVFGRDAPPPSARSARGNEPSTTTDQHGRPHERVLLMSGPPGLGKTTLAHVVAQHAGYRVYEMNASDARTAGDVHNRVRSALESDSLQGHGRPTLVVIDEIDGAMGGNEALGTTGFVRALVQLIERGARSSHKTRPLLRPIVCICNDLYAPALRPLRPLARIVRFHRPPTPMITRRLREICARECLAADARGLTMLCDVSHGDIRACLHTLELLHRQGGSVHVDAIQRASLGMKDSVVPLQHIWTQLFRALDQPHSSLHGSRVHALVQELISYADYDRLARGCFEHYVHLRVPGQGWQRYESALDWLHFSQSLMHGAWGGTGQGSAFELLGFVPWAFVAWHMLFANVANPIPEYPPREDYERHLQLTATLELVDTLRGCLPASLAPFYSRRTVACELAPALVRILSPDLKVSTPVPTRETKAALDALVDTMLMLQLSFEPDRDEHGVVMYRIQPPIDVFGQYAGQASGLVGPSRHGAKQYVQRAIDAEQRRRRTAAALASSGATLQDTAAAATAASCEMLPPFPTPSATATYRDFFGRVISTPKVPQTPASTARASPSASSHGPRVFYRYHEGYSNAVRKPIKLAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDT1</accession>
    <name>A8QDT1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_4234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000023">
        <property type="protein sequence ID" value="EDP41421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728635.1">
        <property type="nucleotide sequence ID" value="XM_001728583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDT1"/>
    <dbReference type="GeneID" id="5852936"/>
    <dbReference type="KEGG" id="mgl:MGL_4234"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4234"/>
    <dbReference type="InParanoid" id="A8QDT1"/>
    <dbReference type="OMA" id="EHETPGM"/>
    <dbReference type="OrthoDB" id="3338536at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="167" mass="18014" checksum="5F510078CB04D932" modified="2008-01-15" version="1">MPTTNWANPATQIPNRKPIKTMYRVPLGSGASITELKSRVMTAKEASRANTLLNKRRGAALVVEHETPGMCVVPPIAVPKGVQLGVGPGQKNVMQSLLDSQVRGGDYSMYMPGAALRKLPSDVKQAKNPESLAQIQADQALAENATIHPIGRRFLIERLSAQLHTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQZ6</accession>
    <name>A8PQZ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732777.1">
        <property type="nucleotide sequence ID" value="XM_001732725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQZ6"/>
    <dbReference type="FunCoup" id="A8PQZ6">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQZ6"/>
    <dbReference type="GeneID" id="5857083"/>
    <dbReference type="KEGG" id="mgl:MGL_0552"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0552"/>
    <dbReference type="InParanoid" id="A8PQZ6"/>
    <dbReference type="OMA" id="AINDEMW"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="530" mass="57145" checksum="04C09C02B35DC687" modified="2008-01-15" version="1">MSTRQLRGLFPHEVIVAASSSSATTQRGGLYVLDPSSSASAHTPLMHFKGVAHAAPHGLSCTVSSTHACHDGGTSGCIAVIESDKAVLSLYSWQRDQPITRIVLPQKMSCVALSPRAIYLATGTADGRLYVWHVRSGALLCSFEAHYRGITAIQWTLDSAAIITASQDTRACVWSWPSIMQYTDLTHTGGPAPAPYATLSDHTLDISDMYVTAGAFPHETRLWTASLDGSVKSWDLASRRLVSTYVLDEPVRVLAVDPLERFFFVALHERVCRIDLYASENMSGSGSSAGSVLRFRGGRGASGVSERVSDAPHIELNTPISALALSLQSSHIVIGTHLGHVHVVDGMTLQTVRTLAAHASSMSQSAGVKTPVTSLFVVPRPVDLPSLLDLRAPSGAKRSQHSNDRDAASSAYMDPLPVPTVPTQFARTLSSPLDQPHVYVRVGDAHSSHVRNVHRLFTWARQNQAAQSATSLPLDPKAPERVAHVAADSSTETPALMQRIRTLEAQVHRAKALNDQMWQHLVQVEAHSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR06</accession>
    <name>A8PR06_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732787.1">
        <property type="nucleotide sequence ID" value="XM_001732735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR06"/>
    <dbReference type="STRING" id="425265.A8PR06"/>
    <dbReference type="GeneID" id="5857093"/>
    <dbReference type="KEGG" id="mgl:MGL_0562"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0562"/>
    <dbReference type="InParanoid" id="A8PR06"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21201" checksum="A249A43E997F5874" modified="2008-01-15" version="1">MRCLYHIDLSQPGVSQPGVPPASLTDQGVIPVLERHGTHLRSLHLGKNEALSDATIDAIGATIECLILDFLAHVHESTWIRLWHRCTQLTSVSVRGIGMTDASLEALVRHARSLQVLNINSNDDLTPAAFYALAEARLPLKTLDVGFVRCVDDSILSMLADAMPTLKALYVFGCPRVKHFSRADITVVGREQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR28</accession>
    <name>A8PR28_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732809.1">
        <property type="nucleotide sequence ID" value="XM_001732757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR28"/>
    <dbReference type="STRING" id="425265.A8PR28"/>
    <dbReference type="GeneID" id="5857115"/>
    <dbReference type="KEGG" id="mgl:MGL_0584"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0584"/>
    <dbReference type="InParanoid" id="A8PR28"/>
    <dbReference type="OMA" id="YSLPQNW"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="9">
        <location>
            <begin position="65"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="10">
        <location>
            <begin position="240"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54507" checksum="13BD825A020ED368" modified="2008-01-15" version="1">MPPAPPLAVTVWGGTSSLPSIDPTSLYVLALLQLAHVPNVCAFAPHSFFHTDAVPALYTQAPPTVTSPDHQHPSYHELGELIATTPSSIRTFLCEHSSLDKSLRDPSHAAKTRALHAWLDDELSDLVLHTLFSLPPNFQKVTCTALSGTRRRLIPSSLPRRMRAAVRARLESPNINLWGVGGSWERQERREAQRWKTTAGLAEARDPISYMPRPGFRENPNLASDVREEWERSRLVSRARRLFKSVAVYLQEREFLGHWNEPTSVDARLYSLLAPWVFVDWPVDPLPSLLRAEFPILVQHTKRMHEWLWQATSSSWAWHHQTISLWPSVSLPNRPSWVSLWRGLSSWWRSSANETSNLAPTLRYGRIAWMTSAILGPILWVLLSGIIVIEFVDENESVENEDDGDDSTYTHEQDENEDEDEDEDDQDFSEKAKTSDDKDEHEDDETKYDEAPEYDALDANEWMDDDIDVDTDDDGENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR30</accession>
    <name>A8PR30_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0586</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732811.1">
        <property type="nucleotide sequence ID" value="XM_001732759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR30"/>
    <dbReference type="FunCoup" id="A8PR30">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR30"/>
    <dbReference type="GeneID" id="5857117"/>
    <dbReference type="KEGG" id="mgl:MGL_0586"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0586"/>
    <dbReference type="InParanoid" id="A8PR30"/>
    <dbReference type="OMA" id="MDTQAFC"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="5"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="404"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP45597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="532" mass="60292" checksum="AABFE0083DC2698D" modified="2008-01-15" version="1">MPKPFYVTTPIFYVNAEPHIGHLHSSVMADVLRRYAELRYRGWSTYGTIPNDETTRALMTTGTDEHGLKIQRVAETMGVEPRALCDRVSQRFEALARAADIEPTRFIRTTEDTHIAAVQHVWNKLACHGHIYLGEHQGWYAVSDEAFYPESQICATKQQSGSSSETVYTSIETGQRVEWTTETNYKFRLSAFQQPLLDWLENNREVIQPSNMYDHVLAEVRSGLQDLSISRLRSRLTWGIPVPGDPQHTMYVWMDALVNYMTALGYPHMQPGWPADVHIVGKDIVRFHAIYWPAFLMAAGLPLPRTIVAHSHWTVNKAKMSKSKGNAINPFHALHTYGVDTMRYYLMRIGGHIGTDADYAPALLEEHKRKFLQGQLGNLLSRVLAPKIQARLTGTGLLLARPTHWAEAEKRLIHACTHLPPTFDAHMQAYEPSKAIQAVFDVIALTNELVQHSAPWSTDTPLDAVHRCVFASCEALRLCGVLLQPVMPRAMTTLLNELQVPASQRTWDSLYAWQSHIRMRDTAEKIAPLFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR79</accession>
    <name>A8PR79_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732850.1">
        <property type="nucleotide sequence ID" value="XM_001732798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR79"/>
    <dbReference type="FunCoup" id="A8PR79">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR79"/>
    <dbReference type="GeneID" id="5857156"/>
    <dbReference type="KEGG" id="mgl:MGL_0625"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0625"/>
    <dbReference type="InParanoid" id="A8PR79"/>
    <dbReference type="OMA" id="ECWAIIA"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117:SF4">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="332"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="598" mass="67103" checksum="9BD56E4AC26F9432" modified="2008-01-15" version="1">MRQGVLFRVEHAHIHGLRGVVHESASPPSFSWTIHDDAERECWAIVGPASADAGGQVRQTIVDMLLGRKRPVLANALHVRHPHMHPMFDANALQKAIRYVPFETRPATTGEFTDYATRYGSIRDEDRVTLFESLMASRGIFTGLIARQRMRPDPLATTQNNTGLLKWENEHVRTAATQRAEREREMIQRIAPTLRLEPFLTRPVISLSNGQMRRARILDALVQGAQWVVLDDPFKGLDPSSRHDVSELFERLHAQRMPRICLVLREQDPIPSFVTHVLRIDEQGFIMELGKATTHARPAVDELYPHGSYALVRRNAQQGIGVGQGASVPPIASFRDVSIHYGDATVLQNVSFALRPGARMVLVGDNGSGKTTLLSLLLGDHPRSFAFDAEQLELWGAARDAPQNAHTLLQRRVGHVSPELFHAFPRKSLEAGGLSVADAIASGFDGIFTHRRRTAAQMERVWRLIRQFAPELTHTNLCEPDPELVGKLPFASLPHGSQAVVLFLRSVVHRPLLLVLDEPFQGMSQRQVAKTRAYIDGESWVYEGIDDRTGGESESESERERMWRENLVLVTVSHYESEWPRTCGRLLRLSAGRVAECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR90</accession>
    <name>A8PR90_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_0632</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732857.1">
        <property type="nucleotide sequence ID" value="XM_001732805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR90"/>
    <dbReference type="FunCoup" id="A8PR90">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR90"/>
    <dbReference type="GeneID" id="5857163"/>
    <dbReference type="KEGG" id="mgl:MGL_0632"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0632"/>
    <dbReference type="InParanoid" id="A8PR90"/>
    <dbReference type="OMA" id="WNNTIGA"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000008">
        <property type="entry name" value="Endoplasmic reticulum metallopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053974">
        <property type="entry name" value="ERMP1_1-A_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22249">
        <property type="entry name" value="ERMP1-TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="17">
        <location>
            <begin position="145"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1/1-A TM" evidence="18">
        <location>
            <begin position="421"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP45643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="915" mass="101525" checksum="2E5C7DA773964351" modified="2008-01-15" version="1">MHYRLPAPRAVTSVDAPKPQGPASDAWYREYFAHTLNSQEAATYHPSLLESHTFDGPLHSYFSEANAMLTMQYLSEDVGFRVVGTQQHIDAEVWLEEVLRRFEGTHATGTNYSTQVEVFRQQSDGAHRFDILGFPVWKQYYGMSNLIVRISDGTEESKANSLLVNAHLDSTLPSPGAADDAAGVSIMMEALRVLTLRGAPRVRHGLVLLFNNGEESLQDASHLYMTQEVITRPTVRAVVNLEGCGVSGPTLLFQATDPALIEAFRHVPHPFGTVLASDVFSSGIIMSDTDFRQFQHYGHGLPGLDMAIVGSSYLYHTRRDVPKYMERGVVQHLGENAFSLIESLCLSESSPLPTIRPWPYETKRILPIYFSIFGSFLVLISPYLFKNLITTLSVLVNFMLSSINTTERRVRFIHMSMLSTIGVALSYVAAIVAANAVAFFLRSVGSPLSWFQHEFHALLAFAPPAIAAIVGVQLFVHSLAERTRRPYLEYTSFTGATVFYTLLLLLMNFYGLGSAHVMFIATLSYYVPVLINDLSLIGLKRIGEGVNPDARMHLATYFVHLILPCTFGTEGIVAFLDLLVPLMGRMGTDAPADHVIASLVAALVTLVGGFVPALCHRYGRAFMQKAIYALLAVSCITTALFAAKGANVFDDKHPRRLFLHHVENVTSGEWHLSYSVLDAGAKNPQMDAAILRTALGSEPNATLSWDDAPAAAPDMDILFPLTHFIGVTRVTLPRSAERDELSLDGNRWSNVRLTCEDTHYDVQNQTRHVIMRLEHPQLAWSTVSFDADLVDWDFPEPPPMGMQRHHMKDVSRLGSDVFEMRLVMRVAPEDMAAAEPVPETLLRSPPMHEAMPVPRGHIPMHFSGIDSFGMYPHHKNVSMDRLSMRTLAALDDELQRDFPEVDAMLLSIVGGVAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRA6</accession>
    <name>A8PRA6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732233.1">
        <property type="nucleotide sequence ID" value="XM_001732181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRA6"/>
    <dbReference type="STRING" id="425265.A8PRA6"/>
    <dbReference type="GeneID" id="5856544"/>
    <dbReference type="KEGG" id="mgl:MGL_0008"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0008"/>
    <dbReference type="InParanoid" id="A8PRA6"/>
    <dbReference type="OMA" id="IASRFEY"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="10">
        <location>
            <begin position="447"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="806" mass="92056" checksum="8C882C2676937FCC" modified="2008-01-15" version="1">MDKDDIEFEVPELAMPQPLGQGMPLLSPIEKRTFDVDAFLCSRTIGQDVHAIVKELRTYRQTLQENLVLIINEKYRDFVSLSTMLQRETDGIIELSNKDGLSEVQMALESMLATMRQTEIDIESLGHEEEANIHERRYLNMLLDIDRTVHDLGHLLGITTNEESDHMVPLGRMTLDELAGFDVDEQDDFEQTFEAGIKTHPLTLFQSMTYAYQRYTWLQHLLGTVDREKACGNLLRLEPFLKKIYSRLFDHTRLLHEQSFEQPKEQACESLILALRLSCELGESAVEAMLRRISAHDIEPKIEGCFAPPEHTHSKLYFPFDANEPVQLETLTHLSWDKPIISKSTSELIRTYNALLDATKETTDIFDATERVGGSMMDAFNHLWWEKVSTAIEQSRGSQLFFIGNADEFYLNYTITQAFLDELESLAPSPRAAKAFRAHPKTVALQRRWAFSAFFQLRARELVTSLEQDLQFTSTRDVPSCETEPQKISTEFSHPGFRSLLRTFAAPWYMTRHFPTLSAREWRLSLHVLCRYRSWLKGQITSLSVSELDIEIPSHTAASTAPNNNGLSNDEVNALRNAVGFLADIRLFEERVRAVFDAYISPKLVRDAKGLKEDADDMLKVIREAMEESLGAYNYTLPGVSAFMLQILRKRCTEPLRHVRAANSQYRAFSRGALETQASTEPSIFIPMIVLPLRQVFVGDSQSPIRRLPMEQTVAWIDDVLDHVFSRYTTAIDTITRNLESLRRLKRGTPGLASDEAASDKRVYAQLSADIRSLAAHVEEFARDAELPLRLESPAWQALRDSTHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRL4</accession>
    <name>A8PRL4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleotidyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732304.1">
        <property type="nucleotide sequence ID" value="XM_001732252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRL4"/>
    <dbReference type="STRING" id="425265.A8PRL4"/>
    <dbReference type="GeneID" id="5856610"/>
    <dbReference type="KEGG" id="mgl:MGL_0079"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0079"/>
    <dbReference type="InParanoid" id="A8PRL4"/>
    <dbReference type="OMA" id="WSDLGNF"/>
    <dbReference type="OrthoDB" id="5594057at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02509">
        <property type="entry name" value="GDP-M1P_Guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000046">
        <property type="entry name" value="Mannose-1-phosphate guanylyltransferase (GDP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049577">
        <property type="entry name" value="GMPP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054566">
        <property type="entry name" value="ManC/GMP-like_b-helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051161">
        <property type="entry name" value="Mannose-6P_isomerase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390:SF1">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22640">
        <property type="entry name" value="ManC_GMP_beta-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159283">
        <property type="entry name" value="Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="6">
        <location>
            <begin position="105"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP isomerase/GMP-like beta-helix" evidence="7">
        <location>
            <begin position="411"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="49896" checksum="3A6FCB89FC3DFA34" modified="2008-01-15" version="1">MSGAQHDALLAQILTGLSDIRREMSRLNDRLDSVERTEPNTPTMGNFSPIFSPARRQSFAAYHSSLDRWNPERARPHEPTKLTLSLEQDEAPVEATDPSLNLWSVVPAGGAGTRLWPLSRENCPKFLLDLTGNGRSLIQNTWDRLLPLSGTGKLMIVTGRIHTGAVQGQLPQLIPSNVFSEPSPKESMAAIGLAASVLARRDPTAVLGSFAADHIVSGREAFESSVREAVMAAREGYLVTIGIAPSYPSTGFGYIKLGGKLDLPDAPNVQRVDEFKEKPDARTASAYLSTGEYRWNGGMFVVKAATLVDLMAKYVPDLHAGLQKIAEVWDTPNRDAVLNEVWPTLPKIAIDHAVAEPASKTGQVAVVPATFGWDDVGDFSSLSALLPAEKNQARVLGEPSLVLTEGQMGGIIVPASGRKIACLGMDDVVVVDTPDALLVTTRARSQDVKKIVAKCKKAHPEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRV4</accession>
    <name>A8PRV4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732361.1">
        <property type="nucleotide sequence ID" value="XM_001732309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRV4"/>
    <dbReference type="STRING" id="425265.A8PRV4"/>
    <dbReference type="GeneID" id="5856667"/>
    <dbReference type="KEGG" id="mgl:MGL_0136"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0136"/>
    <dbReference type="InParanoid" id="A8PRV4"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="582"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1084" mass="120752" checksum="49D090863A599455" modified="2008-01-15" version="1">MERVQYSLERTLPQLKLLDEHSILSKDELRSVTSQRQGFEARLIRRKAEKFDFVRYIEFEDDLHALIVLRARERNRKIMNRVRAGDEDAKSQLLPRSFLPKQAASSSAQCVAIFERMVRKFRWDLDAWDRYIAWAKKRKMRVVAGRVFARALALHPMQPSLWISAADYELNTQADTTAARALLQRGIRTNKLTDSAALSAHETSKLRKTQNGARASREPGALRWTLTEYESDVLRLWVEYFRMELVFIERLRRRWRILGLDSGDTLVTSEPSADTTAMPWSQREGDAMDEATHAAQSVALDPNNTRNNEHKEHSSDDYLDEEDEQVAAAEAAVDEQVPDGEDNEVGSGKFESSHAAHAPAVQGVRPAADMAIPPGHHQIMNGSIPLVLLENIGQHIPQALQFYLYTALLQLVSSFPFFDSVVVKRHGEVLSIRTSQGILGSGDRLRRRLMQALLSACMRASDNGDTCDGGKLGAWMWKCIHPLYHPFSHDVAAKISTAALPASQAERELDTNALLHGASQLHAVYSPAIDALYTYAQVPADLRQERTVAGTYDPWQACQPVLFLLELLSRRLVSATHTEISRGHDGVKSPYTKTDVSLQETTAQSGSGNDHDDDEEAREHDQSHADAELDDEESIHSAEASDFAVVPEATPFMRMLTTHGDLPKVIQCAVSLFRAHQGEQEQVPLAFLATLRFLSNPLRSAVDESHLLTYIAQVDAKLVEALEPHVPWLTVEKLSRELRAHGKAAWDQIQSLVSVQRTNPCAWVLYVNAAPMWSSDKAWTFKWDGQADSSIRDAQRVWIPILDACTGATHFANDAHASVWALLTLWLGSSVVEDTSLVSPEFARQTLWLRYLDWVRDAATVSPNAKRAKRASVWAWSLYKQAVQKTGAVLASSMLVGTARESAQALHDKVVCRMSAFSLSTAAAAAAAKAATPTGAEALVSSEKTNDHAKDDTTAELDTHHAQDLALSFLLANSSASTRCWLEIAHIETMRVVIGVQDLDEPCKKRITSIFQRAMAQAEREAQVPHTVDAWLAYLSFLAHTQRDMPQALAELARAQSCIRRIGGAEAAVAFEHQWQQNVAARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS14</accession>
    <name>A8PS14_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">deoxyhypusine synthase</fullName>
            <ecNumber evidence="7">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0173</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732398.1">
        <property type="nucleotide sequence ID" value="XM_001732346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS14"/>
    <dbReference type="FunCoup" id="A8PS14">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS14"/>
    <dbReference type="GeneID" id="5856704"/>
    <dbReference type="KEGG" id="mgl:MGL_0173"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0173"/>
    <dbReference type="InParanoid" id="A8PS14"/>
    <dbReference type="OMA" id="HSIINAN"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="386" mass="42559" checksum="2C3A5144E2DDD902" modified="2008-01-15" version="1">MNEKEGAVPSSAQSAVLMRSEPLPSEAVEAIGPQFEKQDPNDLNALMGSLATVGFQGTSVAEAVRIIERMRTWRLSEDPSYNPAEDEHSQLPKDDPAHPTNVRCTILLGYTSNLISSGLREVIHFLVKNKFVSGIVTTAGGVEEDIIKCLGPTYLGSFHLDGATLRKRGLNRIGNLIVPNDNYCKFEDWVMPILDRMRAEQDSAPPESNGERFAWTPSRVIERLGHEINDERSVYYWAAKNQIPVFCPALTDGSLGDMIYFHSYKNPGLTIDLVRDIRRLNDMSVKAKKAGIIILGGGVCKHQIANAMLFRNGADYGVYINTGQEFDGSDSGARPDEAVSWGKLKSKENGGDTVKVFCDATIVFPFIVAQTFGRAYWAQQLPKVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS17</accession>
    <name>A8PS17_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732400.1">
        <property type="nucleotide sequence ID" value="XM_001732348.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS17"/>
    <dbReference type="GeneID" id="5856706"/>
    <dbReference type="KEGG" id="mgl:MGL_0175"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0175"/>
    <dbReference type="InParanoid" id="A8PS17"/>
    <dbReference type="OMA" id="KFWPFRT"/>
    <dbReference type="OrthoDB" id="3013446at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="28"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="106"/>
            <end position="207"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="219"/>
            <end position="725"/>
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            <end position="1757"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="106"/>
            <end position="122"/>
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    </feature>
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            <begin position="126"/>
            <end position="142"/>
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            <begin position="2317"/>
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        <location>
            <begin position="2585"/>
            <end position="2599"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="2599" mass="277945" checksum="7F67E8C2A37E057B" modified="2008-01-15" version="1">MDAPSRSAGSSKIRYHGTSPTNTRDWDYIERPERPERVERLERLERLERLERLERLERLERSDRSERLERPERLERAERLERTMWLSPPMNVDPPLPPNALQNVREAQSRMYQESPPTSSMHLDSEENDPGSLDEDLDEDESVTSSMLDDDSVRLVPRRSPPSVSEIHRLPNPTPPMFDNIRRLPPVSPPPQSSPRSQSRTGMPPLPRDAALHVAMAKERVARSTTPTRRTPEFVDDELPPPYERPSRASHSSVRRMRPSNTPSYTHSHSHSRSHSHSSLNHTPDSYDFMDHEPPALRRTVSTVTIVRKTSSKPDIDKIPSIPPPRPKPNVYVPPERESEPPTPTMDDWSTTFDSLDAFEPGSLDLFGEMKRPSRAPSSTANRREPDEPSTPASQDDESIESAFEAPLKTLPAPKEPNKSSIRLVSRNSIESVPLSPSSSATRSTIIRSPASPASSFPVSRDSSRWSENSPMINRSSGLPDATPRDWRSSHAFSPPSAHMPPSTPGAKSSQQAASYKMSSSALAASSSPPPMPPTSPFHHATPKSTATSSSQTPGPGSLAPRSQGAPTSAPANTSQGPSDSSSTTSASSRRGRSQPAAVASSEPPASHARMNPAPNATTSPAPSAPGFGHGPSSVYAATTMSPGPSTLSSMPSDPAPRNSSVSMAAAPAGGLRKFSDSTLPGTSTAMTSPAVASHVSSPSTAASFPMASSRGAAPAVASPPSPIVYEQVPRSGSYLSLMERVKLASSINASAREIPSHHPPTSPPGWNRVVDEMYGRSTGPAAHAYETSLSQDRVSGLDKGANMDDLDDQASVTSPTTESEAPTLPSKDSMWLVDSPSSQPERSSIPTPPLSQTQQPQGHTPVLARHGLQTPPRRSSPTTVTAPQVPSHPATDAGPGHLIARTMSDRTIPQHAPKMPSHTSTNDVLATPPRPTHASMTHPASATPPRPTVRHASETSPRTTKDQFSATPSRTLQSHSPTQAQGPAADTSTMSQDQVSEPVDARRKYQGSATPPPRRTSFPRTADVSGTPPRSKDDGHDMSSPQTRHRLSSSSSRTATAARTEMPPPTSTRPASHYPHDRREHGSKTPTRSTSNHPTTHMASPRRALNAEPASAAQSITKRSPDMPTSSVSHHGRVTPKAQSTQIPSTTTSSLADSSADKARRTFVHEPSYGVPSSRVERQSTPGQASRPSDRPEAPAPREPSSRVYAYEDHERNESDAKGSHEDTVDDADEDVDREVDEDLPEDELDREAQDDEIEEGELEEDLDDEMEDEVEQGLDEGSDQDLDNEPDDESESELTQDDTYAFERTGEFAREPSRESHDQEGSASHEAPRTQAMEPPTEAFERMQLAKSHGARRTAERTRVEPPSAASTAKERQEPERPAEKEGPRSVLRPTERVPSIREPSPEQVSPSPKKQERPTSNPFRQLRSLRDHGHTPDTESSSSYTRNSAGTMTGTEVPANATSGSGPGASATSMPDPPPTREMRVQTPVQEKRFSAAMMTQTPMSEAQMSAVTAIQSPAQENPASRSVTHTNEPPAQQSTQEDDDLWDDHMYMNMPGQLPLNEGDDVSSDNELKAPAPNDSEAVSPAWVGAMLDDSMQDDVTPEPSPRIDSGGDLEPRLPEFSMPGQSPSMPQTQLHADHQPYERAGPSQLQSQSRSQHQHQHQPQPASQPASPPWQSSSPERSSSQMPQPSPPQPLPPSQSHQAKSPSGFATSDPIPISRPTAKGKSPELSIPIPTSPTPMPWTSLSHGQLSPPITQIAGSPLLGMLGTPTNAHHTLAMSPTSPPPFTSWLPESPTAAPVRTQDYSSVQGASPSLKVVYGHGGASTYSFGPSPSRAPSTSLGPMASPASAPAWTSTPSTSKRTWTEPRSVHVIDPPTKPVGSPHAMLGTPSSNMKARESPDVVIETPPLKMPESPLRSKPTITRKTSLSPSSSKRNASLPMSSDQAGVPASPSRMPGSSRITNGSPMRPGVTAQHPLILVPGGAESSTPPLSQTQSPAPAPAPAPLPATRHYHSPSEGQVPPSGPVHPPGPKRPSSPSQYPGLLPQHSMVAPFELQNRALVLPSGVDPRQPGSGFCAECMMRDEDMADVTVNRPDVWERASDADFHEAIEAEQQIRVKHAGDISKMPAFLSLTAIKVQNIAHGITLSQANLREHTALARLSPSAKARSVFMFVQQQRRILGIDDDEPLASCTTSSSAPTSPRAKTSGPLAPPAVASGVAVPPSAPAPASRSVAHAAGVTTGSAADPTTPTTPARRATSSRPKTPSTATSPPRSKAHSSRSPHMPGASLPAEAPASGRRTRSRSEPRPVTPKPAVTGPTPSRSATPTRARSPTHAKSPSRAASPSTRAASPEHVVASPLARTASPTTRATPPPRTTSPTRAAEALRAAAPPNRPVMLTQPNSPSHVPLPPTAPMVYTQEPLYFSPTSGPKVLAGFPRAPAVQPVADPGSAPAAPHVLAPAPVFAPAPVPMPAPAPVSMPAAHADSSGQDDSVVMPSSDKSLDEEQDGVRRRTSQSQSLRGLFRKMTHRTEDSDGTPSRKAKQSDQNADTSMGEEEDTHRSFWKRFTRSPKSSSSHKSSRFHAAHTSPPPPVPPIPSNETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS40</accession>
    <name>A8PS40_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732413.1">
        <property type="nucleotide sequence ID" value="XM_001732361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS40"/>
    <dbReference type="GeneID" id="5856719"/>
    <dbReference type="KEGG" id="mgl:MGL_0188"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0188"/>
    <dbReference type="InParanoid" id="A8PS40"/>
    <dbReference type="OMA" id="FCVEDEP"/>
    <dbReference type="OrthoDB" id="5398391at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="226"/>
        </location>
    </feature>
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        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
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        <location>
            <begin position="428"/>
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    </feature>
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        <location>
            <begin position="533"/>
            <end position="563"/>
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    </feature>
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        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="60530" checksum="6522DE8A7E8E32B8" modified="2008-01-15" version="1">MKADVIEAENIPSASADELATILRELLACPEDVAYTLGSQSQAAIMELPHDSRPVTYDGLVDVARFCVEEEPGWSQTDCVKLIAQYPRLDTFAPGEPRLSQLCDEYETRFPGFRLITSDEVHDPQLALGEIEHVMRNQKSKEPCSQTSPEWQAELNRLMEMLWDVSVDRAAHLRPGSVPLTEPTTAAQSTSAQTVETPHVRSAPALATDANLKRNQPPVSSHERADDEPFLSLSSFRALAVASPGLEKFFEHDLVRSFRLEDVQWSSTGGAFAWHTAPVVPRMIAGRQGPEEKSTKSSAGTTSLASALLHGNTASQDTEAPVSYSRDITTGTRGKVVGFLGGLLGEEGKTRMDALADQVALRLQTHSVRGPLPSFVEDSRGPTSEQKNSSSPWRSAWMRGRSAASNVVSDARASGLTGRLAGVFGIQGNSSSSSNNSPSVTTAFSSQNGAGEHAGQQQNASDNILTQSALRGSDLARDGPEAAVASLRAANEALVQERDTFVIDEMPASADNTMIEMDDDVDHDVEGLDALIAGDTSHASHNDETLTDMPHDRNDSSSQENAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS66</accession>
    <name>A8PS66_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L30 ferredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732427.1">
        <property type="nucleotide sequence ID" value="XM_001732375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS66"/>
    <dbReference type="FunCoup" id="A8PS66">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS66"/>
    <dbReference type="GeneID" id="5856733"/>
    <dbReference type="KEGG" id="mgl:MGL_0202"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0202"/>
    <dbReference type="InParanoid" id="A8PS66"/>
    <dbReference type="OMA" id="IVEPWIA"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="29393" checksum="6DF81D7D552D565D" modified="2008-01-15" version="1">MFANRHRSSVPSANDVLIPETLLKKRKADAKLREENQAKALELRKARKQKRQVIFKRAEQYVKEYKAAEREQIRLRRLAKSQGDFFVPSQPRVAFVIRLRGVSNIPPKPRKIMQLLRLRQINNGVFVKLTAATQQMLQLISPYVTWGEPNLKSIRELIYKRGYVKVDKQRIPISDNSVIEAHLGKYGIISVEDLVHEIATVGPNFKVANRFLWPFQLSSPTGGFQKRKFNHYIEGGEYGDRESDINRLVRRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSF8</accession>
    <name>A8PSF8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-rRNA-processing protein RIX1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732475.1">
        <property type="nucleotide sequence ID" value="XM_001732423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSF8"/>
    <dbReference type="STRING" id="425265.A8PSF8"/>
    <dbReference type="GeneID" id="5856781"/>
    <dbReference type="KEGG" id="mgl:MGL_0250"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0250"/>
    <dbReference type="InParanoid" id="A8PSF8"/>
    <dbReference type="OMA" id="RIHALCM"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="918" mass="98822" checksum="3B0571913348169C" modified="2008-01-15" version="1">MPRHYTSTYDLVRLQHEVRVISYARRRAMSLPILPLEPLAAALESRTHVQEAWMSASMTNAIRKASDTRDTDGLHVLEKRINSLLSTSLAQNKKEPCWEIGADVARTFVEECGWTVVELHGQVWIQHAHAHLEQVAKYLGACVDVGSNPIDSGAELILASVVSLTQLVGYEVMGSEGESHPEFHRTIVTPNVPKIGHALVSVCEVASQVWGSVYSHASIPLSKCLDVIQDQVVRHATTYRTFVARIHALCMQILFGPYATLQTDIPPRCVYLTASATRLLSAIHVTGAASSSLQPDLDARTFSGSSKLTQAQLWAATVAEILDALIVCVCGSAPSVSWHASGLSAPNTDPLAWMSPSAADFAQSIPACFGRCELLLGSTSCPDAVGVLPYFLSTPTLRAVPVPIARCVQIATAMIQAHIPPGHRAPIDQLRFEHMYLPQIRQLGARFLVQVVMAFQQQAWPFVYASEAISKLSAMAEYTHGTAERSLALCALDLLLARDSVLAPNGFAGGAGIPLDPASTVVQRIARICIQTLSAFVVQEPMSWSCMPPLKRTRTFESDAIVASTRVLQDAIMSKTCTEMDMVCHAASVLVALFGLLNSSAAPGHRDLARTGALALVGLTEVLIDARVLDASNDAMLTMCERCVDVLTSLVVSHAGALVAYVLARVHAILVRGTQSSISRVRIACAVGVSRLLVVIRPRVPPLTDHIDSSALEEQVAATETQDQVPLPVAGWQGPESVSTSFATIDEVAPRVHKGVAGMSEAIASMSDAHIDLETPHSVPAPTTSIARSSVNELHRPIRSEVTRPNFVSPEKHEQVRTALDSFSGTDADDHAQRCRSRDGMPHGPGVATSSFQSFGERPMESDHINETHDHSVQVQSGKKAAFPSDITAAGNHDDDDDDDDALPLLDADASDDEVETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSH0</accession>
    <name>A8PSH0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732481.1">
        <property type="nucleotide sequence ID" value="XM_001732429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSH0"/>
    <dbReference type="FunCoup" id="A8PSH0">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSH0"/>
    <dbReference type="GeneID" id="5856787"/>
    <dbReference type="KEGG" id="mgl:MGL_0256"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0256"/>
    <dbReference type="InParanoid" id="A8PSH0"/>
    <dbReference type="OMA" id="ETDFVWG"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="291"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="635" mass="71268" checksum="9A0F333D20CF2161" modified="2008-01-15" version="1">MTKGAMGLPVHTLQPDDRVRIFPRLLCLLLACIAGLWISTGRFYTVESESLSSMERICPQQPAYDPTEALQKLTIRPPSVLHSVKLLSEAVQLSTEAMDEILSDDEELESVTRNSTFSPFSDWIEKSFPFIHAPDSPVRREFVNKHGLLYTWEGTDPSLKPVVLMAHQDTVPVNIYTRDRWIHPPFSGYIDLENQTVWGRGSLDCKLWLVASLSAVETLVQAHFQPKRTIILSYGFDEETDGKYGAAHLASTLFHRYGPNSVAMIVDEGSPVLSAIDPGSFGLPVAGPAVAERGELSMRITVHARGGHSSMPPPHTGIGILALIIAKLEANPFPDVLGEESRASVLQLQCLRDAPKMPAALRRALRRVESAERTRKECRKPCWQHWWKHIGMLSRQRRLDAARNELMQSLDYASRMLLKTTQAVDVAYGGIKVNALPEISEAFVNHRIAPYASVRTVIQHYKDLLVPLAKEYGFSLVVDRDDLNLSLDKSTVSVNISKTGLGYDSHPPSPFEGEKAEAWRLLSSVIRQTWHTDEPRIELRSMDDESVPEQRKYNEPVRVAPSIMFANTDTRWFHDLTNNIFRFGATSVHPDLTGMSPYLNVHTVNEHVSIDSVVKATQFYTNLLVAADHEQIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSR0</accession>
    <name>A8PSR0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_0301</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732526.1">
        <property type="nucleotide sequence ID" value="XM_001732474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSR0"/>
    <dbReference type="FunCoup" id="A8PSR0">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSR0"/>
    <dbReference type="GeneID" id="5856832"/>
    <dbReference type="KEGG" id="mgl:MGL_0301"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0301"/>
    <dbReference type="InParanoid" id="A8PSR0"/>
    <dbReference type="OMA" id="VRPCRYY"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727934" description="Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial" evidence="15">
        <location>
            <begin position="21"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="64"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP45312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="393" mass="42559" checksum="AAA1C3103A8E2005" modified="2008-01-15" version="1">MHATWLAATTMFFAAAATRAVRPAASRPLARVARSSVLCRGFAAEADAPTSAYNKEKDADGKYTVTLFSGDGIGPEVSGAVQEIYRAANVPIKWEEADVTPSINSQGKQVIPEETVKSVRRNTVALKGPLATPVGKGHVSLNLTLRRTFNLFANVRPCVSLKGFKTPYDDVNTVLIRENTEGEYSGIEHEVVDGVVQSIKLITYGASERVARYAFHHAKQNGRSRVTAVHKAPIMKMSDGMFLNACRNVAKEYPDVEYDEDLLDRACLSIVRDPTPYSDRVMVMPNLYGDILSDMCAGLIGGLGLTPSGNIGRDASIFEAVHGSAPDIAGKDKANPTALLLSSIMMLRHMNLFEHADKIEKAIFDTIAAGERTGDLGGDLGTRAFTERIISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSR6</accession>
    <name>A8PSR6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0304</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732529.1">
        <property type="nucleotide sequence ID" value="XM_001732477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSR6"/>
    <dbReference type="SMR" id="A8PSR6"/>
    <dbReference type="FunCoup" id="A8PSR6">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSR6"/>
    <dbReference type="GeneID" id="5856835"/>
    <dbReference type="KEGG" id="mgl:MGL_0304"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0304"/>
    <dbReference type="InParanoid" id="A8PSR6"/>
    <dbReference type="OMA" id="YWARRTA"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="136" mass="14364" checksum="4A52738E9463AAEB" modified="2008-01-15" version="1">MSGGKSGGKAGDASSVKTQSRSAKAGLQFPVGRIHRLLRKGNYAQRIGAGAPVYLAAVLEYLTAEILELAGNAARDNKKSRIIPRHLQLAIRNDEELNKLLGGVTISQGGVLPFIQSELLPAKSGKSKKAMGSQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT57</accession>
    <name>A8PT57_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732596.1">
        <property type="nucleotide sequence ID" value="XM_001732544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT57"/>
    <dbReference type="STRING" id="425265.A8PT57"/>
    <dbReference type="GeneID" id="5856902"/>
    <dbReference type="KEGG" id="mgl:MGL_0371"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0371"/>
    <dbReference type="InParanoid" id="A8PT57"/>
    <dbReference type="OMA" id="MITYAAF"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="75" mass="7962" checksum="692F443840E20CA6" modified="2008-01-15" version="1">MRSMVQLDAFLVSAYLDFGYFLTGILLMTGIALPMVLAHTGIVTGAAAIMSLLGGALVYGTMITYAAFFHTPDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT64</accession>
    <name>A8PT64_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine synthase</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteine synthase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_0374</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732599.1">
        <property type="nucleotide sequence ID" value="XM_001732547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT64"/>
    <dbReference type="FunCoup" id="A8PT64">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT64"/>
    <dbReference type="GeneID" id="5856905"/>
    <dbReference type="KEGG" id="mgl:MGL_0374"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0374"/>
    <dbReference type="InParanoid" id="A8PT64"/>
    <dbReference type="OMA" id="VVPMAKG"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="15">
        <location>
            <begin position="88"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP45385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="421" mass="45984" checksum="4E87162B9F30B7C3" modified="2008-01-15" version="1">MLSSLLDRLYALTQNKHKSVWTLGFLIGLATGLGALAFSKMHKAFVYAYVRRKVLRVSPKHAAKACPYQDEFQPIELVRGGSIVSGVEGLIGNTPLVRIQSLSDLTGCDILGKAEFLNPGGSPKDRVALQIIKEAEDSNELVPNVGSWIFEGTVGSTGISLATLACAKGYNCCIIVPDDVAEEKATLLRRLGAKVECFVNEARFRAQQWMPSDNEPYARAYFADQFETNANFYAHYDHTGPEIWSQTHGRIDAFVAGTGTGGTLSGVSAYLKEMCAAHDDQSMLASSILTVAADPPGSGVYNRIKYGVMYSETEAEGTRRRHQVDSVVEGIGLNRLTRNLEMGLPFIDTAERVSDDEAVRMSRWLAKHDGLFLGSSSAVHCVAAVRTALRLKQTMAQSHPGVRPVIVTILYVCSWSTREPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU18</accession>
    <name>A8PU18_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="19">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">MGL_0515</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732740.1">
        <property type="nucleotide sequence ID" value="XM_001732688.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PU18">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PU18"/>
    <dbReference type="GeneID" id="5857046"/>
    <dbReference type="KEGG" id="mgl:MGL_0515"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0515"/>
    <dbReference type="InParanoid" id="A8PU18"/>
    <dbReference type="OMA" id="MLDQCRY"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1498"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1211"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1938"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1222"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP45526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="2189" mass="247998" checksum="79E22C057E88042F" modified="2008-01-15" version="1">MRSRGTFRRRGSSMLQRGLSRAVPPSSTNVEIAASQIEERFAAVRKHDEIDEKMGFLRLEQGETRQAWMVNMHPTLLPDDAHPSGRSGVDYYFIQDDTSMFKVTAVYQPYFLLGCYPGTESLVEEWLRRRFEGVLHSVERKHLDDLKLPNHLVGNQRTALQLRFMNVQDLLTVRRDLLPLAQDAQKKVSAVEAYANMLSDVSGPSSADVSVGLDMDGAYTMASASSTGGKSAEQCIIALWEYDVPYYLRVAIDNDIRVGLWYDVSFHEGAVSLRAVPERVKRADPVVMAFDIETTKQPLKFPDAEIDAIMMISYMIDGQGFLITNRQIISEDIEDFEYTPKDEYEGPFIIFNEPDEVALLRRFFAHIQEARPTVIATYNGDSFDFMFVDVRARIHGINMKHEIGFAKDADDEYKSRHCSHLDCFRWVKRDSYLPQGSQGLKAVTVAKLGYDPMELDPELMTPYASEQPQTLAQYSVSDAVATYYLYMKYVHPFIFSLCNIIPLNPDEVLRKGTGTLCETLLMVQAYKNHILMPNRHIDPIDNTYEGHILESETYVGGHVEALEAGVFRSDIPTDFRINPSSIQMLIDDLDHALNFSITEEGRMTLDDIENYDEVRGTICGMLEALRDKPIRQDKPLIYHLDVAAMYPNIMLSNRLQPDSVVDEAMCASCNFNRPGMTCDKRMKWAWRGEYFPAKRDEINMIRHALDMETFPGRDDRQTKTRTYQDLSPSEQSALLQKRLADYSRKVYKRAHDTKTVIREAIICQRENPFYINTVRDFRDRRYEYKGLLKKWKKNLEKANEGGALNDTLEAKKMIVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGITCLTGATIIQMAKELVDGIGRPLELDTDGIWCMLPGTFPENFTFRCRNGKPFGVSYPCTMLNYMVHQRFTNHQYHDLVDSQTGEYKVHSENSIFFELDGPYRAMILPSSKEEDKLLKKRYAVFDEDGSLAELKGFEVKRRGELQLIKDFQKQIFSKFLLGDTLESCYAAVARVADQWLDVLYSKGSTLHDEELIDLIAENKSMSKLLSEYGAQKSTAITTARRLAEILGQQVVKDRGLACKFIVSAKPHGAPVTDRAVPVAIFNAEPDIKAHFLRRFLRDPSLNNFDLRHILDWNYYIDRFAGVIQKLITIPAAMQKIPNPVPRVRHPDWLMKRVAAREDKVSQVKLDRIMTSEAVRSRSKAVTAGVASSEQETRSRVDPVRVSDPVQQPKLTSERDVPIPSIDEDYPGWVSAMRGRWRKQRAERRGIERPRTTLGGLLEERSSAMASATWDIVQLAPTIRPGEFRMWVLVDRQMHALRLQVPRQVYVNFLKPPQPGMLRASYQAEVVHRTLPRGAKVHHLMRFTIPESEYVAREAHFSMLLNHPNVDAVYEKQVPLDVRAIMQLGSACVLRPDVRLSHALEAGLNLADLAHAPAASQSFYLRGGRSMRCLYLYHASDQKRHVFVLVSSDGATKVHLVDSAGLKQWPSIDALYAERLTAMKSLGRIVDGQGAFDYPASLSTQMVDVHTTETHAFRALVRDIRDARASRQGAAILAICTSRPLSYYEAAMHVTTELPILLVPASRAEDSMPALGWQPYAARRMVNCYLRTSVWLSRWIELAAHLDIPLGNMARDFAIFGSDLDMARRLQQNDMVLWWSPSPRPDLGGREDDAHPGGGGAAEDWDALEVTNPGAYANVCLEVQVTDLALNCVLQNASVHAMEGIGAASMALDTASHSLDEYARGQVPVSADLGDAVLTSQTFSTVRSMRFVHRLMRKTMLQLLADLRRLGVQVVYASYSRLLLLTNRPTAGSAVAYGRYLMSAATTPDVFRHINLSIVHIWEYLIFLDMANMGGVIAHEPETTDLPEDVDIEMAWNVQAFLPQALQDRFAKIVGVFIYELYQAKRIMHARFAERPVMRVLSQNTQPAESAAAAAAAAGMAEDKESPQHASSENAQHIVAHVMTPRLLRAVNEIQEEQKGPMDAEAWRFPQLPGSHLTMTNPTLEFIKATTRVLALQKDAALEAQVCKRNLLDLIGVREFSPAAEWHNPCLPFRLPWVICHFCNDDRTLDLCRDPDLISAREDRQWACTRCNTLYDRTNIELRLITLVQQQVAQHAVQDLHCNRCGRINTSNLASYCICSGSWVHKTSPADTRRRLLHALAIAQFHAFPLLEATVQMWLANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUE8</accession>
    <name>A8PUE8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732077.1">
        <property type="nucleotide sequence ID" value="XM_001732025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUE8"/>
    <dbReference type="GeneID" id="5856383"/>
    <dbReference type="KEGG" id="mgl:MGL_0670"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0670"/>
    <dbReference type="InParanoid" id="A8PUE8"/>
    <dbReference type="OMA" id="IMIHAAT"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10661" checksum="7CC1457D4F9FCDF8" modified="2008-01-15" version="1">MIPCPSREVATTIQQVICVDKELRPHDVEKSLDVHTADDGRADLHVTMRATTLRHLRLSLNSFLDDTALIVRTMDALKPGMPTQAVSALEQGSIGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUF1</accession>
    <name>A8PUF1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732079.1">
        <property type="nucleotide sequence ID" value="XM_001732027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUF1"/>
    <dbReference type="FunCoup" id="A8PUF1">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUF1"/>
    <dbReference type="GeneID" id="5856385"/>
    <dbReference type="KEGG" id="mgl:MGL_0672"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0672"/>
    <dbReference type="InParanoid" id="A8PUF1"/>
    <dbReference type="OMA" id="WQTTHEL"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="469" mass="50220" checksum="34FECB51B27249C1" modified="2008-01-15" version="1">MSSSGSLEQVIHDRASLIAVKELENKLRRHQIVSTEAIAQATAKTVRTVISATKVWQLDELVRIIRIVGHHLQNAHPFEPVIGNVTRRILYLLREEVKALTTLGTGAASAGAEAPSSSGTARTPPHPSVVQSLAALSMSMPASPASSMHASFEMPVTPAPNRSFSISDLVFPSSTMATPPTCANAQSAYTSDVNRNATVSPGNVSSPLDTPSQDGSESPQRMSDSMSSDDDAIPVIPSHAYQLKPLLIQAIQELLDEFESVDTSIAKDARDHIHSGEVILTLGYSTTVQTFLRAAAKHRKFIAVVPESAPSFAGHEMARALAADGLSVLLVPDSNVYALMPRVSKVILGARCVLANGGILASIGAKAISMAAREHSTPVVALAGVFKISPDWSWVSPERLRTGNQGPTAQLVNYASSHTLAEKAEIENPLWDFVSPADIDVIITNVGEHPPSYVYRLIQENYHEEDLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV09</accession>
    <name>A8PV09_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP45006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732220.1">
        <property type="nucleotide sequence ID" value="XM_001732168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV09"/>
    <dbReference type="STRING" id="425265.A8PV09"/>
    <dbReference type="GeneID" id="5856526"/>
    <dbReference type="KEGG" id="mgl:MGL_0813"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0813"/>
    <dbReference type="InParanoid" id="A8PV09"/>
    <dbReference type="OMA" id="WEMAISY"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="264" mass="30516" checksum="1183F799935F2CBC" modified="2008-01-15" version="1">MALCYMSLCEWQQTHECFTVLANENNWSKALYHYARAAALYETGSPAAQEEAKEIMERVPSMSQRIAGKSIPLEKFASRKSRKMTQYGYLFHPAMEFAYLTHCYTTSPPRALFRRFLPIIEQELERLTSQVSPVFDDLCLAHFLHGVILRNLAYPEKHVYLASSRQYLSRERAASMAEDSLMFVAKKGVLCEYDHYMLYFCHYELGRLYISMGRYAEAREQLDMVLSGKNLGDHGRKGKYSMQNMCVLRSNGALEMLQSKSQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV79</accession>
    <name>A8PV79_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731552.1">
        <property type="nucleotide sequence ID" value="XM_001731500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV79"/>
    <dbReference type="STRING" id="425265.A8PV79"/>
    <dbReference type="GeneID" id="5856350"/>
    <dbReference type="KEGG" id="mgl:MGL_0820"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0820"/>
    <dbReference type="InParanoid" id="A8PV79"/>
    <dbReference type="OrthoDB" id="3360015at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="183" mass="20582" checksum="7EF511F2A886E712" modified="2008-01-15" version="1">MPKPQVGDAEVVTEPARELRKPEPLASGRRQRHIMSEQRRRNQAREAFQQLSELLAIGRTYGARALGLNSGAGTGVEDEELDDRTDTEEDLLLCCDEEELQRRKRNAQRRARSRAVTGKQTRGKGRGRGGSAGHAGSKSAVLFQVIDLIDWLDGREEHLRRDIEVLEAHLKLLGPQAKRTRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVR6</accession>
    <name>A8PVR6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0938</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731670.1">
        <property type="nucleotide sequence ID" value="XM_001731618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVR6"/>
    <dbReference type="GeneID" id="5855975"/>
    <dbReference type="KEGG" id="mgl:MGL_0938"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0938"/>
    <dbReference type="InParanoid" id="A8PVR6"/>
    <dbReference type="OMA" id="CTGRICA"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11253" checksum="9E2CCA9B54FEC2D3" modified="2008-01-15" version="1">MATPTRPKPLPTYYTLGAGAAAGVFELACLYPLDVVKTRLQLQSKQLGDGKGPSRGILRMLSSIMRHEGFSALYRGIAPLLLLEAPKRAIKFGYVCTGRICATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW12</accession>
    <name>A8PW12_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731735.1">
        <property type="nucleotide sequence ID" value="XM_001731683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW12"/>
    <dbReference type="FunCoup" id="A8PW12">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW12"/>
    <dbReference type="GeneID" id="5856040"/>
    <dbReference type="KEGG" id="mgl:MGL_1003"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1003"/>
    <dbReference type="InParanoid" id="A8PW12"/>
    <dbReference type="OrthoDB" id="3366779at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="165"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="165"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="598" mass="63179" checksum="D9AE01477EC54E6B" modified="2008-01-15" version="1">MADEANTSHVEGIWHHDPLQALNTSGTFVQLCQQPYMDHTGMPEASSPPQDNMNRLNGQDPTFMMRSVMSPAKFHHCSVDDASTAEVSHTRSAFGWFGGPPAQRMAQTSGPFVPHLRPMSVGSGIKELHSQVNTKTDAASSVCVPPHAHRRHMSADNRSDPLIKGKTRPRRAFTPEEDEALKRGFDKYGSQWALIARDPAFRNQRSSTDVRDRFRNAFPEEYACAGYKPRVKQSKRVNRAKDGIHASSSTSQRAARHSRSDLTQQRRKSARSDEPGHLHTTIPSPLGTDITCSSLDGPSSATSNNSSLTDKDPLLIRAESLQQSSQLSQPSPLQLDAVVSTSPSSMSASPSFSMSPPSFLPHVGPTSPLQEALVGLPTTQAISPIPAMIPITLPPPLPTATGVSHVTAATPSISQASITGPGSGLSLSPQVDHGSGHAAGSIATNVPRSVQAPAFNGIAVPSSSTPSISTTPFPTISSSFDHCLMPRTPAIAPFDEKQDPMYSTSMASLVPGMSMSHSPMSFHSSESVVAASSPSSTFIPALSNAGSGTSIGTHLGGSAAGSHYSADVDAALMSIVPAGPPGRSHTLEPFSTHDTPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW34</accession>
    <name>A8PW34_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZW10 C-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731749.1">
        <property type="nucleotide sequence ID" value="XM_001731697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW34"/>
    <dbReference type="STRING" id="425265.A8PW34"/>
    <dbReference type="GeneID" id="5856054"/>
    <dbReference type="KEGG" id="mgl:MGL_1017"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1017"/>
    <dbReference type="InParanoid" id="A8PW34"/>
    <dbReference type="OMA" id="YFKFAYL"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="2">
        <location>
            <begin position="815"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="960" mass="106439" checksum="41CD59F197DA1048" modified="2008-01-15" version="1">MSRPLEAVAKLKDSFEVRDLDSVSELMPIVQNELHICGVKVDWAQAQVTKEAVGSLADYASVDQLISICGHLASDMLKQAHAQVESGLHVKRTDTGILLSIHPPSKLAETLQSNVMSDEAVCDMSDVLRKDVFEPILRTSRRWVATQLEHGLELSCSSDVSTTTLELGASVPELVAILSMIKETLGAQPTVFLMLSKSLIPPIIELFKAHLLRCKPPIGSSQDATKLKQQMVSCTLEFHHALVQLQYVSDQMPRTKHLPCMPEPLSDLPVWTRTFDVVCKQHFLGCLIDQVRVLVLQRNDKCWDTETKVMTSPIHTPQDNPDLRIQSVYETGPLARSLRTVPQADGPPGLEFDLKPELVSVPEPKQEAEPQTQPASAFRPKPSKSKKPTLGGVKIGAKLPVPVQEVSSSLPPPKAPTPPPKVPTPEAQDDWGWGDEEADMDAWDEPDKSQADDMGSSIQETSEDPWNKTEPRNKDAGTRDFELDETEQMGSSSKDENENGNDNENEKMEQRRPPKQLNVDAVPNETESDDWDWGEDEDEDENEIKKMLAEPATRLPAAVSDDPASGSNGADSERVDSTGATSLASDNNFGPKSSAAQVPDSSVPSNMQLEESLDAWEWDNDTGMEETPTPALQDPDTAVSTAPIASAASASPSMTATTAAMSSTITVSRRVLDICRVLENQWNHLDEDVPMRASLAHGFLMSVQLFRGLMPIVHAKVLQHVALLGMLYVNDCSYLASELRSYASKCTKWGAFRLPGGPTFEVSLAMEADCLYNISAQWREALMNIQLNALHESLDGTDSFARTDMPDQYDACVRSIEQIEHILTHLSSVWSQVMRADELMWLLCQLVDAIFVRVLREMEDLQDISEQESNRLAELCRKLMDTASNVLHGSETDVPTYFKFAYLPDILQGSLADIEYLLFDNESGSALADYTRDEMNLLVRALFADTPQRRRLLDRIQRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW81</accession>
    <name>A8PW81_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731776.1">
        <property type="nucleotide sequence ID" value="XM_001731724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW81"/>
    <dbReference type="STRING" id="425265.A8PW81"/>
    <dbReference type="GeneID" id="5856081"/>
    <dbReference type="KEGG" id="mgl:MGL_1044"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1044"/>
    <dbReference type="InParanoid" id="A8PW81"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="107" mass="12659" checksum="E19D2DEEC7ACF943" modified="2008-01-15" version="1">MRDTSYSWSTNIAGRKRWRFFAPADAALLRRFPEQRTSELASTFKDMERRRALGELGAFCDGFSGWPGWEQARLRVYVIEQELNHNWCNAYNLRSMYIAMENEVRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWC6</accession>
    <name>A8PWC6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731801.1">
        <property type="nucleotide sequence ID" value="XM_001731749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWC6"/>
    <dbReference type="STRING" id="425265.A8PWC6"/>
    <dbReference type="GeneID" id="5856106"/>
    <dbReference type="KEGG" id="mgl:MGL_1069"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1069"/>
    <dbReference type="InParanoid" id="A8PWC6"/>
    <dbReference type="OMA" id="HEACEHT"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="529" mass="58279" checksum="0377C0E4625ACFD2" modified="2008-01-15" version="1">MTDSSRTPGPTAPTTLTGISHTSGPSSLSASTATPSTSTTRPRNARVPVPVPVYTETPRSGLRKLNLPTVGATQAAADAAAAAMNSPPSFSRGDRSVSSLTEPEPVDTERTRYFRRLSALPPALPHVPTMPKPVLKFVDATRGVLFSLSQIYAAIAQYTAVCTDERLVAHFQRVLGIANKAMSVLIGALDRLDASSRTAVPESSMVRHVLEACDEALRAFRRAATMLHMQLPQLRQSVDPRFSRTLELLLVRKCCLKLRNSAQLHGRPQVAEVVPFLMQDSSTQTSAADTSIPALSSSRYANRPSLTESSFATDAHDLLASDTSHPATSTPLKKRTARMWTTQSMRSPRLSPRQSRRSDASPHVPLSPSSTSTPSRMRALTTRRDSMDDALLTLLSQVTDSAMHIWTDLRDYVQAGLRRDQEADSDHDTRTRRLRDVDESCVSILDLTKRLQMMRERVSDTSARSHASDVQELRDQSNQFVRVRMNRWCRSLVSLSDTPGLTRRPSSIYPRSFVLSLWPTHFHAISCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWI0</accession>
    <name>A8PWI0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731839.1">
        <property type="nucleotide sequence ID" value="XM_001731787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWI0"/>
    <dbReference type="STRING" id="425265.A8PWI0"/>
    <dbReference type="GeneID" id="5856144"/>
    <dbReference type="KEGG" id="mgl:MGL_1107"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1107"/>
    <dbReference type="InParanoid" id="A8PWI0"/>
    <dbReference type="OMA" id="ITHAPGI"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34000" checksum="FBF2295A91037312" modified="2008-01-15" version="1">MTVSTVPSLNASLHTSAPALESKRKRASRLRRQKNQAQQSIKQRMFEMSAPDPVLAHRLNDEGRATWENSELAKLILTKTEVWGLMEDRRGRLQTVEPTPRAEEDAQIASDVATYGGPRRLNFGLDTSDRRTLFQSLPRVMTTDRAQDLTYSSLAHEGSDAMAQDLAQLESEQAQSAETLGRILDLRNASGKGIQVENTRRIIAHFGRSTDSGSPDTGSPEVQAALLTYRIRNLAEHLQQARHDNSNRRSMRHLVHQRAKILRYLKSRDPIYYQSFLPRIGVEARGVEGEIVVPGKPKVKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWJ1</accession>
    <name>A8PWJ1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731850.1">
        <property type="nucleotide sequence ID" value="XM_001731798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWJ1"/>
    <dbReference type="FunCoup" id="A8PWJ1">
        <property type="interactions" value="776"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWJ1"/>
    <dbReference type="GeneID" id="5856155"/>
    <dbReference type="KEGG" id="mgl:MGL_1118"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1118"/>
    <dbReference type="InParanoid" id="A8PWJ1"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="417"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="650"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="558"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="794" mass="87842" checksum="31F0F99CA689A5CC" modified="2008-01-15" version="1">MAFSSSGTCSFSIALKQSCLATSELWSLAVYAQDHAQDTLVATGGSNGHVRLWCMPHSVSQRGLQAAEQGSGSAHFFNAHGTLDVPSSHRISQLAVYGSYLAAASGDRAVHVYRIRTPEEAHKKQQRRIKRAREKGDEGAAVDTIPMTWLTRLDAYVIVRPTIGRIRSFAFPSGHASSNHLHHTPSQHESMTSSDASVPLLCSLTTNSAEIHSIPPPPRTRAEKQSGAIEPSVSHALELPGHRSDIRAVALSSDDTLLASVCGSGQLKIWNVRTYRCIRTLAVSAFALCVTWLPGDRYVVVGCKDGSLHTFDVPAGVAIESLEAHTGPIWSCVVHPQGLSAVTGSADKQVKFWEFEMVASDEHTPPQLSLVHVRTLQLTDDVLSVKYSPDGRLLAVSLLDNTVKIFYADTLKFFLSLYGHKLPVLSLDISDDSKLCVTCSADKNAKIWGLDFGDCHRSLFAHDDSIMNVAFEHGMQGGGLMGGREGASHRFWTVGKDAKVKYWDGDRFVGIQVMEGHHGEVWALATGHRGRLVVTAGADRSIRVWEKTDEPLFLEEEREKELEQMYESAAPSQDEPATGPAAEAEATGVSKTTTESLMAGERLLEALETADADLAQRAQAERQGASADSVPLHPLIQAVFHDMDTPDTHKYVLRVVEKIPPTHLEDALLVLPFDRVVSLFRYIDVWVTREWNVSLGARILFFLMRTHHSQIVSNRVMRTTLLRLRTHVKDVLVKQKALVGFNLAALRFLQQQFTMRRTTELFERPEIQLHELDEAAVRDKLQEHAKRKRKLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWP4</accession>
    <name>A8PWP4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H3-like centromeric protein CSE4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">CENP-A homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">CENPA homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1171</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731903.1">
        <property type="nucleotide sequence ID" value="XM_001731851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWP4"/>
    <dbReference type="FunCoup" id="A8PWP4">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWP4"/>
    <dbReference type="GeneID" id="5856208"/>
    <dbReference type="KEGG" id="mgl:MGL_1171"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1171"/>
    <dbReference type="InParanoid" id="A8PWP4"/>
    <dbReference type="OMA" id="VHLFEDC"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000087">
        <property type="entry name" value="Probable histone 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="131" mass="15114" checksum="93EFC3BECC2E9138" modified="2008-01-15" version="1">MSLRQHIHREYASAYLAQEKKRRYKPGTVALREIRRYQRSTDLLISKLPFARVVREVADEFIEENYDSSASAVGLRWQSSAILALQEATEAYLVHLFEDANLCAIHAKRVTIMQRDIQLARRIRGVWGGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWX1</accession>
    <name>A8PWX1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731979.1">
        <property type="nucleotide sequence ID" value="XM_001731927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWX1"/>
    <dbReference type="FunCoup" id="A8PWX1">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWX1"/>
    <dbReference type="GeneID" id="5856284"/>
    <dbReference type="KEGG" id="mgl:MGL_1247"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1247"/>
    <dbReference type="InParanoid" id="A8PWX1"/>
    <dbReference type="OMA" id="CVNQYNK"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="472" mass="52827" checksum="419F38A1B9B41815" modified="2008-01-15" version="1">MHMSARRAAAFTGTPAYIAKTVAVASLTAAAAVTLTLQGNLAGNIAECDATASVNKMTKVSTKPDISALDISVLDDTNVPMRKRMETYVKLLQRRLVDDIEAEENAGRTSHEPKHFTVESWTRKEGGEGTSCVIQDGEVFEKGGINVSVVYGNLPPSAIRQMSADHGGLTERVGYKIEGRDAEVDGLPFFATGISVVIHPKNPMGPTAHFNYRYFELMHPKTLKDGSPNPRYKKDEPVAWWFGGGADLTPMYLFPDDAKHFHEIHKAAADSQDAAFFPAWKRWCDNYFWLTHRGESRGIGGVFFDDLTLPSWTSNKATFIPLVDGSKNTDRQLVSAKQHDKESLFRAVRAMGDAFIPAYLPLVHKHKYDKFTSQNLEWQHLRRGRYVEFNLVYDRGTKFGLMTPGARIESILMSLPLFARWEYMEGTTGTGRQNSTAASMNDIDNQKKYPEEEMRARAAIQDVLEHPQDWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX19</accession>
    <name>A8PX19_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732027.1">
        <property type="nucleotide sequence ID" value="XM_001731975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX19"/>
    <dbReference type="SMR" id="A8PX19"/>
    <dbReference type="FunCoup" id="A8PX19">
        <property type="interactions" value="591"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX19"/>
    <dbReference type="GeneID" id="5856332"/>
    <dbReference type="KEGG" id="mgl:MGL_1295"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1295"/>
    <dbReference type="InParanoid" id="A8PX19"/>
    <dbReference type="OMA" id="LYTHMTV"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="280" mass="31821" checksum="16A521D2B4ABF3EB" modified="2008-01-15" version="1">MGRYAVLVTGPAGAGKSTFCAALMSHAQSLGRSIHLFNLDPAAEQFEYEPTIDIRELITLEDVMEEMDLGPNGGLIYCFDYLLNNLDWLENELGEYDNDYLVIDCPGQIELYTHFPVISRFAGLMQQQFNFRVCATYLLDSHFMDDKAKYFAGVLSAMSAMINLDISHLNIMTKMDLVAQHEKDGLSYAQRKEVERYMDPDPLLFADHDDSLNQSRFHALNQAIVQLVEDYSMVSFLPLDLSNEESLNLILSCIDNILQYGEDEEPIEPKDIEQEESDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX51</accession>
    <name>A8PX51_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731144.1">
        <property type="nucleotide sequence ID" value="XM_001731092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX51"/>
    <dbReference type="GeneID" id="5855451"/>
    <dbReference type="KEGG" id="mgl:MGL_1327"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1327"/>
    <dbReference type="InParanoid" id="A8PX51"/>
    <dbReference type="OrthoDB" id="205569at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="92" mass="10485" checksum="ADEA2C4CBA0C0A31" modified="2008-01-15" version="1">MSSSMPSSTEMASSPIKYSPPSLKAHEQEETPFENEAFKNLKSQDTEGAEPVAIIESQPQMRDFRKENTVFVPSTVLRRQRQQHASTVRQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX98</accession>
    <name>A8PX98_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731191.1">
        <property type="nucleotide sequence ID" value="XM_001731139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX98"/>
    <dbReference type="FunCoup" id="A8PX98">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX98"/>
    <dbReference type="GeneID" id="5855498"/>
    <dbReference type="KEGG" id="mgl:MGL_1374"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1374"/>
    <dbReference type="InParanoid" id="A8PX98"/>
    <dbReference type="OMA" id="PKIDMRF"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="360" mass="39700" checksum="8C0123A4DB691F01" modified="2008-01-15" version="1">MADAVSADAAAATQWLFTREDLQFTPSVTGVYDALLDASSSPNKHLAQTMTSEQERVLRGKGVHLIYKMGEFLQVGQHVMVAAATYFHRFFMRRPLQVHRAGSGWSHYEIAAACVFLACKSEESLRKLPFIVDAVMASLDKSPEGQMRWADRSFRSHHGSHEFAKWRDCILLHEEALLTTLCFDLVVPQPHEALVRATRAMEVEPALARLAWTILNDCMRDPVCLFFDAPVLAAGAFLKACCERHVDPAMYYAARPRDAPRIDTADAYFDWLDAFDVDEDEAREAMTAIDADVYDFHMPLQRPTVSKPAHTAGVRESPAESGAPPTEPLPSATPSDSASAPAAPSVSESDVPEPPPTNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX99</accession>
    <name>A8PX99_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acetolactate synthase</fullName>
            <ecNumber evidence="11">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_1375</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="11">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731192.1">
        <property type="nucleotide sequence ID" value="XM_001731140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX99"/>
    <dbReference type="FunCoup" id="A8PX99">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX99"/>
    <dbReference type="GeneID" id="5855499"/>
    <dbReference type="KEGG" id="mgl:MGL_1375"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1375"/>
    <dbReference type="InParanoid" id="A8PX99"/>
    <dbReference type="OMA" id="QETDMIG"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="59"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="267"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="476"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP43978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="657" mass="72155" checksum="71388EE152561407" modified="2008-01-15" version="1">MMQRYMPLPVAAVRALSTTPCRAKKTRPEPAPSFQSVRKSPSQLLSYDPAELDDTFVGMSGGQIFHEMMLRHKVHTVFGYPGGAILPVFDAIYQSKHFNFVLPRREDGAGHMAEGFARARGVPGVVLVTSGPGATNVVTPMQDAMSDGVPLVVFCGQVATSAIGSDAFQEADVVGISRSCTKWNVMVKDVAELPRRINEAFKIAMSGRRGPVLVDLPKDVTASILKHPIPHSWTSPELSEMPSRETAMQRKSRLGGLLTPADVLPELEQAARLISIARRPIIYAGHGIVAHSEGPQLLRELAMSQDIPVTTTLHALGAFDEEHPLSLHMLGMHGSAYANLAMQSADLIIALGARFDDRVTGRVDKFAPAADVAAAEGRGGIVHFDIMPKNINKVVQATCAVEGDVTANLKRMIPLLSTSPDRSEWLKQIQAWKQRYPFTYEPSNPELLELMKPQEVIEALDAAVRDMKDNVFVTSGVGQHQMWAAQHFRWRYPRTWVSSGGLGTMGFGLPSAIGVKVAKPEGVVVDIDGDASFSMTAMELATAAQYGIGVKVLLLNNEFQGMVLQWQDLFYERRYSHTEMHNPDFVKLAEAMGVKAIRCDKLDELPDKMKEFVEYDNTKPILFEARVVKNEHVYPMVPAGKSLEEQVLHPSFRVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXJ8</accession>
    <name>A8PXJ8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731281.1">
        <property type="nucleotide sequence ID" value="XM_001731229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXJ8"/>
    <dbReference type="STRING" id="425265.A8PXJ8"/>
    <dbReference type="GeneID" id="5855588"/>
    <dbReference type="KEGG" id="mgl:MGL_1464"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1464"/>
    <dbReference type="InParanoid" id="A8PXJ8"/>
    <dbReference type="OMA" id="SYNDENC"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="629"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="789" mass="86298" checksum="D9EC1C240AAC6428" modified="2008-01-15" version="1">MSPRIRKRPSAHLEVSTIGSCSSVVSLDEMAELEDSIAGLHRKPSSDEFSRIVNEISTHRRMNADVRNRRSHQSFASSDDGRSGHSRISSFDGDVSTLSAVNIPPCCCGQPECDVSRRVLQQIHDMESDLQLSAEIGQALLQRQDAIVHRSQQEAEEHAHQRDQLLARLTQTIKETQVLQRQLSQATFNLEAADQSHHALLSELDEVRHQLKQTKMHRIKASSLEAKLERVQTELEDTRVELANERRRFASAEAKQKQVVARRCEELRARWNGERSRMAQAQQAASQAKANIWDAVRARLAAKQGASESAAGASEEDEADPDPFSDDALREIMNEHEALRHENEHLQTLLRSMNDEMAELREMSEGPGPLVGVSLEADIDSSPMPLHASEPRERERRVVSDSSRSEAPSEDMTRRSDGLSEGTAITTPSTSSRAHMDDDVLSYDTGSIVAYGSERDFDTPMEQRTALLSTFLEAASSTYSKLQKADIDSLTTRLQRQKLAGDVGHLSRTTVQANVRDLEGWREHFRKALDKEARRGVPTDSSLVSRRDFFTLLKLQRDILLEIARLRRCINEVHLNPGAAAKLLHEHLGANTLPANRSWISRMLTGVLSTESSSSASSTAASSAAPAAAMSTPSSATPDTSKAPVTSTTVQDSAFVRFVGNEAAPMAVPRSGSSRPSAAPPTRMMPRSRASALSSSVAVHAHGAYANTKSGVLKTKASQPALIEAAAASSGAPNPSPNMVMPWKEPTLRTRARGLSDSSIHSTFLDHGAANDSVVDRVITSNTLTLASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXL9</accession>
    <name>A8PXL9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731295.1">
        <property type="nucleotide sequence ID" value="XM_001731243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXL9"/>
    <dbReference type="FunCoup" id="A8PXL9">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXL9"/>
    <dbReference type="GeneID" id="5855602"/>
    <dbReference type="KEGG" id="mgl:MGL_1478"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1478"/>
    <dbReference type="InParanoid" id="A8PXL9"/>
    <dbReference type="OMA" id="GEHEAMH"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="6">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="AAA ATPase AAA+ lid" evidence="7">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23730" checksum="3BA25A7A7732064F" modified="2008-01-15" version="1">MHVSTLTNKWFGESNKLVSALFGLARKLQPTIVFIDEIDSFLRERASSDHEAMAMMKAEFMTLWDGLTSSTDRILVLGATNRPADIDAAILRRMPKRYAVSLPDSAQRKKILSIMLANVPCAPNFDLGDIVRKTEGYSGSDLKELCRAAAMVPVREVLRSHAGRKTVERARENSKAGLPNDTNIGMSVRALKNSDFFQVDATLPESNTEQESLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXQ0</accession>
    <name>A8PXQ0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731315.1">
        <property type="nucleotide sequence ID" value="XM_001731263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXQ0"/>
    <dbReference type="STRING" id="425265.A8PXQ0"/>
    <dbReference type="GeneID" id="5855622"/>
    <dbReference type="KEGG" id="mgl:MGL_1498"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1498"/>
    <dbReference type="InParanoid" id="A8PXQ0"/>
    <dbReference type="OMA" id="MFSTIWS"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="164"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="359" mass="40017" checksum="E340AAE52B9196DE" modified="2008-01-15" version="1">MPPVPSVTRTPADSTDAEEVNINTATDPIQSTPASSQPRRSLPNIFGGAFGRSSADARKAQSPSRRTSEPPNNPSPAASSIPLGHEGNLSDEQKKILDSFTNELVAAKVISIENAPPYQTTQLLRFLRARNFDLKASKEMYLRAEDWKKSVDLDRLYEEFEFTERAAVSEYGWRMYFHKTDLQGRPIFIQDLSGLDTEKVFSVTTAERIVQNFAVTLEHAVRHRYLACTNVKGETVDDNLMVLNVQGLGLSTFWTMKNKLQELLSILDNNFPELSGRVQIINAPLLFSTVWSCIKGWLPTQTAEKIDISGSDYMPTISALVNMENWPKHLGGKCTCGAKESRPSCETSDNGPWPKQKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY39</accession>
    <name>A8PY39_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731402.1">
        <property type="nucleotide sequence ID" value="XM_001731350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY39"/>
    <dbReference type="STRING" id="425265.A8PY39"/>
    <dbReference type="GeneID" id="5855709"/>
    <dbReference type="KEGG" id="mgl:MGL_1585"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1585"/>
    <dbReference type="InParanoid" id="A8PY39"/>
    <dbReference type="OMA" id="WANHNDE"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF2">
        <property type="entry name" value="FERRICROCIN SYNTHETASE (NONRIBOSOMAL PEPTIDE SIDEROPHORE SYNTHASE ) (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="250"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="834"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Condensation" evidence="5">
        <location>
            <begin position="921"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1260" mass="137762" checksum="1E1B89CFF35DA582" modified="2008-01-15" version="1">MSRVPFPDVTGRRLRAPSRTSFAGNGMASLGHASMNATNITWKDLHEAAQDFGVSPRAIISAAWGYVLYMYVMHECDNVAFDAVDADTCVAISFGPSLCQWEDPISMVQLSEKAWLSDRHVQIHGPVLFVSAPDQDTQNALSLAESTLSRTNSSLSLVFIAHQAQTSTSSSSSHPVALTLLASPSVHIHGSALTQLAQVEHVLHALVHRLDPTKSIPTELMSLVNPHPIFMSSDMPGGIEYERLEDQFLRRAQETPHIPALTCCTSVSPPSFVTWTYEELNKRSDDIAKLVWSRGVGYAASTSSVPAHEDQVVVLCMSKCMDMYASILGALKAGAAWCPIDPGWPPSRQAALLIKSGARLALTTGDDDARILEDVCPEHIQMARLDRPMDAASMLERTPERAHATHLAYKIWTSGTTGLPKAVGVEHVAAVQGMRALQVAVPTALDVPVRPGSLRYLQFAAYVFDLSIFDIFYTWGYGGTVCFAPLDMLLSRLVDVANALEVTHTLFTPAVSAMVPRHAVPTMRVMINGGEKLSQAVADNWSQDCRVVNIYGPAEATLSLTMREVVPDDEVKAHNIGTAFDDALCVLMDGNGQIVPRGCIGELMLGGPQLARGYIGDDEKTREKFVMHPTFGRLYHTGDLARQLWDGQFEYLGRNDDQVKINGVRIELLEINAAVKSVSKHVRDADTVALPGPDPNEPPRIVAFAVCPPPPDVDKVSSHDHSSSLARCESAPAFLRTDDDAVTVARTLRSGTQALLPSYMVPFHFVILSFFPRTSSAKIDRRAVRAAYEALDLAAWEARVGDEQGAGHDADAQHIMTHPLAVRLCSFLPRIGCVPCEQISPSVRFTMLGINSVRAMALSAKLAEAGFHVSAADLVRHDSLSKLIRAYSERAHVDPHECRHAWYAACKHAYASTLNVPHVHVQPATSLQQGMLLESHLDSTRYWISRVMHAQSTVDRLHAALERTARDMDCLRMGFLPLGSNQTSSGSSASPYAPLFAAVVHEEPHITLLSFVGDVLESLRPRVPDAANGQPPWFAAYDSDTQRFVLILHHALYDAPTLDLVLARIDQLCADPNAKAQRTTPWTQALCDLVPSPDQEQVSLDAWSKYLTTMEHTSWPVLQTRRTGPVHTLQIHKRVASISWQALEQTAAQLGTSVRPLAHLAWARVLSAYLGTSRILLGDVMSLRGRRAEYTSTGGPLLATLPVSVDLSKGTVAEQVQHMHMVYSHLQDHASVPLSFVRHLVNCPPDQPLFVSLFCVGNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYC3</accession>
    <name>A8PYC3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731451.1">
        <property type="nucleotide sequence ID" value="XM_001731399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYC3"/>
    <dbReference type="FunCoup" id="A8PYC3">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYC3"/>
    <dbReference type="GeneID" id="5855758"/>
    <dbReference type="KEGG" id="mgl:MGL_1634"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1634"/>
    <dbReference type="InParanoid" id="A8PYC3"/>
    <dbReference type="OMA" id="WTKAMKC"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728010" evidence="3">
        <location>
            <begin position="17"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="28"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="173"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="358" mass="41460" checksum="C97CC0B79DCEB105" modified="2008-01-15" version="1">MILLVMLMKDKVLTYAATCDGKSDVRYPLCQACARAALQSMEERRLRLEQDHKTLSMLERELQRLAIIKGDLDMSDDDMARWRREHDRLEHDVDAVHNACKETCAEIRKTDIEVEQVRYALETLSYMEAKMAKEEQELWYVYHDKAMELERCASSKACLNAEFVHMQKQLASLEQSCAYRDVFCIEQDAYGIGTINGLRLGRHTGTRARPNEQVPWSEINAAWGQTALLLTVLQRKLNYASRVYKVVARGSFSVVERLEPDHAVFELYATSEWQLGRLFHARRFDCAMLGFLTCVQEIYMHAKSLYNDLEIPYPIHSDCIGGISIRLQFHEPAAWNRATRYLLETLDCLLSWTLTCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYT9</accession>
    <name>A8PYT9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">MGL_1723</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731540.1">
        <property type="nucleotide sequence ID" value="XM_001731488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYT9"/>
    <dbReference type="FunCoup" id="A8PYT9">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYT9"/>
    <dbReference type="GeneID" id="5855847"/>
    <dbReference type="KEGG" id="mgl:MGL_1723"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1723"/>
    <dbReference type="InParanoid" id="A8PYT9"/>
    <dbReference type="OMA" id="NIPHKLM"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="221"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EDP44326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="519" mass="57123" checksum="D6CDA10C955DBDEE" modified="2008-01-15" version="1">MFAESSSVEIIRDSSSFGLPLGDPAASQPHLDLGRKQTPVQTPQSHHTAVLALGANLGDRARYIEAAVSSLDAHPSIRVVDTSFLYETAPMYYIDQPRFLNGACKISTSLSPHALLDVCQQIERDLGRTKEHVPRNGPRVVDIDIVLYDHEQVTDGERLIIPHARLHERAFVLRPVCDMMPTYVHPVLQRTMASLLPLTMDGSMTRVMPVKDRMWHWGQQTRVMGILNATPDSFSDGGQHLDLERALDTARDMVRAGVAILDVGGQSTAPGRVEVSVEEEKARILPLIKAIREDPITQETPISIDTYRADVAKCALDAGAMIVNDVSGGSRDPQMLVLVAQRHCPFIVMHMRGDASTMTRLTHYEGGIVNDVRMELQTLVRNALAHGVRRWNLILDPGIGFAKNKQDNLLLLRRLPELVDHCAAGMLRECASPEVHDTTQLHEGPCMSLAHIPVLLGVSRKRFLGDLVHAPSSDPALRMQASIAACVATMATGCVDLIRVHDVAQAMDAVRTSDAIWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ89</accession>
    <name>A8PZ89_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleosome assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730899.1">
        <property type="nucleotide sequence ID" value="XM_001730847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ89"/>
    <dbReference type="FunCoup" id="A8PZ89">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZ89"/>
    <dbReference type="GeneID" id="5855206"/>
    <dbReference type="KEGG" id="mgl:MGL_1898"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1898"/>
    <dbReference type="InParanoid" id="A8PZ89"/>
    <dbReference type="OMA" id="WPVALMN"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31025" checksum="8C16AEE0B006ADEC" modified="2008-01-15" version="1">MTRQPEIGEIPNAVKDDIKALEKELDAAEVEVARYMAKLHAPILKKREDILAKIEGFWPQALTNCVSTNVYIDDEDHPLLDHLTKIDVQRDVNDPRAAKIEFHFSPNEYINDQVLVKEFKLSPEAGEQSAQFDFATDTVPVKTSIAWKSDDVNLAKKKPTTGNIGTGKEGENGANDGEDAEGLEEEDDDFEPGSFFSSFFENENPQIAGSIGRAIVEDLFPNAVHHYEVPALFDEDDEDEDEDEEDEDDEEDEDDGDKEIDLEEEEKRPSKKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0N6</accession>
    <name>A8Q0N6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731060.1">
        <property type="nucleotide sequence ID" value="XM_001731008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0N6"/>
    <dbReference type="STRING" id="425265.A8Q0N6"/>
    <dbReference type="GeneID" id="5855367"/>
    <dbReference type="KEGG" id="mgl:MGL_2059"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2059"/>
    <dbReference type="InParanoid" id="A8Q0N6"/>
    <dbReference type="OMA" id="RERNWKK"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="69"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="215" mass="23576" checksum="FF8B791D226D14C7" modified="2008-01-15" version="1">MTGSQDFFGIDHQTSGNGSITPGAPVHNIAQTPIMESGNPFDKLTIPSEARNQQIVGHPGESVPDSRFKILLALDGTEAGDLAFNYIMGKHGFSPRDCHIFLSTVLPANVLGGPWISGPLTIDSKKQNELLKQLRHQAVERMNPYRKKLQERGYEVTMHVLHGEARASLLKVISYHKCDLCVIGKRNRGWKKGLSSGTVTSYLVSHSPVPVLVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0V4</accession>
    <name>A8Q0V4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2087</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731088.1">
        <property type="nucleotide sequence ID" value="XM_001731036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0V4"/>
    <dbReference type="STRING" id="425265.A8Q0V4"/>
    <dbReference type="GeneID" id="5855395"/>
    <dbReference type="KEGG" id="mgl:MGL_2087"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2087"/>
    <dbReference type="InParanoid" id="A8Q0V4"/>
    <dbReference type="OMA" id="QKKCPWV"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="525" mass="60231" checksum="FB6C392AA22348A7" modified="2008-01-15" version="1">MRLDAQESDDDDSDEEWDPSDRVSQRDIARIRLANELDPWERWENACHSRAWRPVHRARSVLPSSASASSTPKPSSHNNDPSIDEVENILAQFQIQQSEVEKKEREGFQKRNTSLWEGIEAAIRQAEQRTADEAQRLVEARRKQEEAEAKARRAREEELKRIDAEKQAARAKQLEEEAKARERAQQDENERRANVFRGGSHMWPGAKTEYAHWQERMKYVKEDVLPSIAQRADWRKQCFTAKRAITPKVGQLTNSQTEIMRITVAISDILQQARDVPDHDAATRLYYWMLNHLSKCLIRQAEQEVAARQETAFPLARLIMGLLLRGHAALGDVFMARLVKKCPWVLAYIPERASQDEAVYRRRIGFKTPDETSQAYASRIAGIMALYFACIQTSLESVMASAALPTSTQLSDAAKHIPVELRPGRLWTWQSRSLTPPLVEQGLIVSLWCTFLEIAGPVSLQRYKRQGTKILSLLLEHGIYKKRLGSKEDNEVQHAAFIRLTLILETWKMKQTLVEHVSPGRDMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0Z1</accession>
    <name>A8Q0Z1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAM86 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731103.1">
        <property type="nucleotide sequence ID" value="XM_001731051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0Z1"/>
    <dbReference type="FunCoup" id="A8Q0Z1">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0Z1"/>
    <dbReference type="GeneID" id="5855410"/>
    <dbReference type="KEGG" id="mgl:MGL_2102"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2102"/>
    <dbReference type="InParanoid" id="A8Q0Z1"/>
    <dbReference type="OMA" id="RCQNNIR"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42008" checksum="C10D0860124DB64D" modified="2008-01-15" version="1">MASNTVAHSAQVQLYIQYNARLPPRSPAFQWPSGPVLLVAQLGLDAILFGQNSTPGSTIEYDRAFLKHLVKHIDEAIEECSEEQAASLDTTKEDLTVDDALLERYMTLVSLPETASSVHGTHIPCALHVIHFFPTDDALTLHPVLGRCESVVLRQEGAAISQGTTGLTTWEASLRLAAHLTAQSPQIWHPQARILELGSGTGFLGLVCSRLFRFCSDPRTDFSLVLTDVEGQVLNRLQETVNLNNAQNVEIEPLNWVEVSAGEPEALEQIRRIRPTCILAADVVYDPGLVPCLTDTLLVTLQNGTTRDGQRPYALVASTIRNPDTYEQFLQSLRERHMRWTIVEAAQPTWPNLDTLRLFPSVHNPETEGQVCILHIEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1V6</accession>
    <name>A8Q1V6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730846.1">
        <property type="nucleotide sequence ID" value="XM_001730794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1V6"/>
    <dbReference type="FunCoup" id="A8Q1V6">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1V6"/>
    <dbReference type="GeneID" id="5855153"/>
    <dbReference type="KEGG" id="mgl:MGL_1845"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1845"/>
    <dbReference type="InParanoid" id="A8Q1V6"/>
    <dbReference type="OMA" id="LARKDHM"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="455" mass="50499" checksum="15474AE2DBB6AB48" modified="2008-01-15" version="1">MPSIWVCYPGAPYTHRAAVQAARRVLEPLQWSVIDADSKERSDSVDVPTHVDAYLADYDLLPFDILLGSSQRCSSYVIRKALIRKHHLAKILHAYSVKHSLPCNKSPCPRTWTLDIQFADELDELLADDLYDLRDLLEEGDGKAWFILKPGMADQANGIRLFSSVQQLRDIFEEFEDKDDENSSNEESTNAVVASQLRHFVIQEYVSTPLLVAPGNPEAPPRKFHLRVYVICVGGLQVYMHDDMLALFASTAYQPPNVTAPRDLRAHLSNTCFGARHTAPTDMKDGNVFRWQDLIGRPAYVPGRSEPVELTSAHIDAVRKCAAVCIGRTMEAVAREASIHWQLWPNAFEVFGVDLLVGCEGNADGNLDPASLRTWLLEVNAVCIHKGGGRGTTPESVCYLCQQPDFAQSGDELSGVVDHVFERVVQVGVLGESPWPEGESHNQCTCCFAAPLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1W7</accession>
    <name>A8Q1W7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730851.1">
        <property type="nucleotide sequence ID" value="XM_001730799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1W7"/>
    <dbReference type="STRING" id="425265.A8Q1W7"/>
    <dbReference type="GeneID" id="5855158"/>
    <dbReference type="KEGG" id="mgl:MGL_1850"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1850"/>
    <dbReference type="InParanoid" id="A8Q1W7"/>
    <dbReference type="OMA" id="KTWWDAM"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="4">
        <location>
            <begin position="147"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="505" mass="53807" checksum="CBB02DE98C1DF4BB" modified="2008-01-15" version="1">MWWLTRLLHEQCEVVFCPSESTRRMLQARGIQRIAIWGRGVDTEMFHPQARDENLRAGWGCKPKSQELLNTLHDQAMSSLEQSKGLSAEEAFIRTPDTFPVSEFSPPPAYESVCDVPPLPGAHFALPPPVVAGPSMAETPKLSGVDNDSKAVVLFVGRISWEKNIRLLVEAFRLLPASVKENAKLVVVGDGPARAELTRLCQKYGLDAAFMGHQKGQRLASMYASSSIFAFPSFTETFGQVVLEALASGLPVVGLHAEGTSDLICHGITGLLMDTIRATSTNQTKSKGVSGMSSATAAAAAAAAAAASAATATAAAAAAAVSSSTSSASSASSQPPVTGSSRHASLTNRLRESTASNDCLPLSASSGRAVPMAASSTLKPGLPSPIPSVKEFASLMSVGTQTFHQCAQAYSILLERLIRDRTLRATMGQRAQQYASNKTWWDAMEAPVRGYEEAIARAGQTNLTDAELEALRNAQRKIAPLSGPIVTTIVILYLAFFVLLWTYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q222</accession>
    <name>A8Q222_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1874</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730875.1">
        <property type="nucleotide sequence ID" value="XM_001730823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q222"/>
    <dbReference type="FunCoup" id="A8Q222">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q222"/>
    <dbReference type="GeneID" id="5855182"/>
    <dbReference type="KEGG" id="mgl:MGL_1874"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1874"/>
    <dbReference type="InParanoid" id="A8Q222"/>
    <dbReference type="OMA" id="MDDHHGT"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF488">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="149"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="420" mass="46542" checksum="7B13FC78512CFC49" modified="2008-01-15" version="1">MSARPQVGRGTSRASSPSNTLYFWNGRLLISKDAPWAIGITGTLLIAGPACWIAFEAPYLSQGVSVAPVVLFAYFWINSVASMLKTALTDPGILPRELDPEPDWQEPPSPHMPFDIEGPMSRPKDRSIALERVDDGGDPSLGTIASIPSVWCETCHVYRPPRCSHCRSCNNCVDTLDHHCIFLNACIGRRNYTTFYAFLCHTMAMLLVGVVGCILKLYYIAAPTTVAQVRADGNKTTRGFVHALKKTPESAVFFFLATVWSIPVVCLWTYHTWLLHQNRTTVEQIRLESTSRLYDVHRPYSTDLFDSGACVRGMAACSAKIRNVVVPKEFATPLTAFEPPSLSRNRTRQMRRTRAPFQHKNPSRNALQVLGRPTFTSFALVRPHGLALTSFPSTSLPVHEIPNESVPASPLYAPPNAKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q264</accession>
    <name>A8Q264_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730695.1">
        <property type="nucleotide sequence ID" value="XM_001730643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q264"/>
    <dbReference type="STRING" id="425265.A8Q264"/>
    <dbReference type="GeneID" id="5854991"/>
    <dbReference type="KEGG" id="mgl:MGL_2149"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2149"/>
    <dbReference type="InParanoid" id="A8Q264"/>
    <dbReference type="OMA" id="MAMYQQY"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21608">
        <property type="entry name" value="RRM2_NsCP33_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000634">
        <property type="entry name" value="Related to glycine-rich RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048289">
        <property type="entry name" value="RRM2_NsCP33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="190" mass="20094" checksum="2D72654C98EE1666" modified="2008-01-15" version="1">MAKVYVGNLSWSTTDDGLAQAFSPYGQLTDYIVMKDRDSGRSRGFGFVTFMTQQEADAAIMALNEQELDGRRIRVNMANSRPPMVHGGMTGASLGYSGLTGGYGAGAYGAAQPAYTAYAQPAGFGYGHQAAYPAYQQQPYGAQPAAFPPTPGFAPQQTVYPYGAQQFPPPAQGYQGQPSPSVPGYGSQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2N6</accession>
    <name>A8Q2N6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730418.1">
        <property type="nucleotide sequence ID" value="XM_001730366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2N6"/>
    <dbReference type="STRING" id="425265.A8Q2N6"/>
    <dbReference type="GeneID" id="5854725"/>
    <dbReference type="KEGG" id="mgl:MGL_2214"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2214"/>
    <dbReference type="InParanoid" id="A8Q2N6"/>
    <dbReference type="OMA" id="EHPGQGT"/>
    <dbReference type="OrthoDB" id="5593376at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="898"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="974"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="809"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="915"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1123" mass="121121" checksum="95F741377D1F6C67" modified="2008-01-15" version="1">MNIPSQNFSVGSVRHLSFSSDEWSQAPVHADAPRPQLPIAKSSDLNALHLDSSANEQQKFLDFHSMSSRSAAGLHLSALAPPGPTDHLPIGLGLSPSSTSANSEQNCRSSPIQPTTVPTPSLETSVNPFSAVDLAHASAHPPVTPGGHNMPLSMASSTTISKDPQEHVGYVSPKHMQRSKQLLPDIGASIDELASAAADARVHFHGGRFDTCNEKIDSIKQLIKRIAEMGMIGLTLSTETQHMRRHSTSALPYGSLMSPDEEKQIGSAATFSALADDVESRKRRLNGELHQEHPFKSQRGAQSNAPSTRSRSRSDLSDFSKAISSTEPHFNAGAVFSPKLHSNVFDFNVPQPASLSQRQQPVHPQTAFSDHTNAPHDVQGVPSTTSNPSSILHSQLMPSSPQNNVTNASSTSVHGTRPLNFAATASTATSSGNENSMHHVTSTPQAMDMTLKSGSHNAWTPSDSIGELKPSLHLESLPMPNMADSSLEPTTPGLKEAPLQHDDANEALNDRSNLGGPELSAELRSVYEETFHEFLTSLCSNLEAKDERGELIHQTLMPKKMARLDESPDFRPFKFRIQAFTNAFQSELQRRGLSEDDLSMRKIKLFLWTHPFISRFNEDGKKAKSKGNHIWIIEARRLPAGRWEFFTFSPKIAAAPSNVAYVNEPWTWNLRIWDPQMSSGSVNVAFSANAMPSWLHWEDEDKVMTGVPHHSSQGGYVNVSAVCMHLGELHHLEHSFYLHVADRSDPSRLEPPTSQTGGVPDEQTAPASLTDLFSPPVSTTPQGAAVQPPKNDALLPQGVSVPMSIPMPSAAQGHGQGQAQQGAGPTPGQGSTTAPGSASMPPGLGSGLGHIQMPAPTHDQANTHVSTPVHTHPPPLTTEGTRETTVPMTGHVQALSQPQAHAQLQMQSPTQAVTQPAAQSPSQLPSSMSSRHGASVQDSQKYDMFDPSRPSHELLPSMPFPFTPPIFMDKHVGPTGASGMDPNALQSSHPPDSSHNETLFTASSNPTSAVFMDKTPVANAPVHTPVLHSTSPVSTLSSTVHTPALGGSFSPQGPEHDTRPMMQMWNHIDQRQREQASSFMLLMPQRPQSFTLNEHPGQGTPISNMPNDMNATLPSVNQHHLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2X8</accession>
    <name>A8Q2X8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730469.1">
        <property type="nucleotide sequence ID" value="XM_001730417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2X8"/>
    <dbReference type="STRING" id="425265.A8Q2X8"/>
    <dbReference type="GeneID" id="5854776"/>
    <dbReference type="KEGG" id="mgl:MGL_2265"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2265"/>
    <dbReference type="InParanoid" id="A8Q2X8"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="8">
        <location>
            <begin position="39"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="364" mass="40995" checksum="699F973D965DB0B9" modified="2008-01-15" version="1">MRRSTFGQPTFATLHSSADVKVSREEAIRMDSEDTRHLIEQRKLALIVDLDQTIIHVTVDPTVKEWAHDPKNPNWCMLKDVVAFQLGSDGKTVSHQPERMDQHDVKSFATDGDENGCWYYVKLRPGLQAFLQSVSPMYEMHVYTMGTRSYADCICRIVDPDGHLFGARILSRDENGNEVQKSLSRLFPISTDMVVVIDDRADVWSWSPNLIKVEPYEFFVGIGDINAAHLGPTKPLVSSGMSDTSNTSAQGETLLTDEQQQRVIAEQCDSRPLQRAAQEKHENKVQAIKDKTQTQGQEKDQSRAQSDGDSQNKEMGHSQDQDQDDLESEVIQQDLVLTDDDTELELIQTVRLRPALLTPLAVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2Z0</accession>
    <name>A8Q2Z0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730477.1">
        <property type="nucleotide sequence ID" value="XM_001730425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2Z0"/>
    <dbReference type="FunCoup" id="A8Q2Z0">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="GeneID" id="5854784"/>
    <dbReference type="KEGG" id="mgl:MGL_2273"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2273"/>
    <dbReference type="InParanoid" id="A8Q2Z0"/>
    <dbReference type="OMA" id="LGAEKCQ"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="47"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="335" mass="36264" checksum="9F48684877414462" modified="2008-01-15" version="1">MSQAGPSNLQVPATEKSQDITSKGEAGLPQPAVQQQRPNKRLVHPSIIIAIWIAFSSGVIVYNKYLLVNLNYPFPVFLTTFHMSFAAVGTRLLARYTTLLNGLSSVEMTMDRWYRNILPIGALFSASLILSNMAYLHLSVPFIQMLKAFTPVAVLIISFSFGLKQLSTTLTAIVTMISFGVAMASYGELDFNMTGFIFQVLAIAFESTRLVMVQVLLQGLKMDPLVSLYYFAPVCAAFNMVILPFAEGLKPFRMLAQLGPFVLVSNAGVAFGLNVASVFLIGAASSLTLTLAGVLKDILLILGSMWILGSTVTGLQFVGYGIALAGLVLFKTHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q335</accession>
    <name>A8Q335_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730506.1">
        <property type="nucleotide sequence ID" value="XM_001730454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q335"/>
    <dbReference type="STRING" id="425265.A8Q335"/>
    <dbReference type="GeneID" id="5854813"/>
    <dbReference type="KEGG" id="mgl:MGL_2302"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2302"/>
    <dbReference type="InParanoid" id="A8Q335"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="49" mass="5617" checksum="05D10DFE2FDCBC3C" modified="2008-01-15" version="1">MTSARVIDALFERTVDIVQSLPPNGPIQTSYEEKLVLYGLYKQGMIFWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q344</accession>
    <name>A8Q344_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor SPT4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Chromatin Elongation factor SPT4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Transcription elongation factor spt4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_2308</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730512.1">
        <property type="nucleotide sequence ID" value="XM_001730460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q344"/>
    <dbReference type="FunCoup" id="A8Q344">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q344"/>
    <dbReference type="GeneID" id="5854819"/>
    <dbReference type="KEGG" id="mgl:MGL_2308"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2308"/>
    <dbReference type="InParanoid" id="A8Q344"/>
    <dbReference type="OMA" id="FDGMIAV"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000002">
        <property type="entry name" value="Transcription elongation factor SPT4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="16">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP43298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="92" mass="10440" checksum="B001E2B08684F43D" modified="2008-01-15" version="1">MSSTAKLRACLRCHFAQTAAEFHAKGCPNCQDMLDMQGSQERVADFTTSNFDGLICMLRPEESWVAKWQRIEKRMVGLYAVKVVGRLPETQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q397</accession>
    <name>A8Q397_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2342</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730546.1">
        <property type="nucleotide sequence ID" value="XM_001730494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q397"/>
    <dbReference type="FunCoup" id="A8Q397">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q397"/>
    <dbReference type="GeneID" id="5854853"/>
    <dbReference type="KEGG" id="mgl:MGL_2342"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2342"/>
    <dbReference type="InParanoid" id="A8Q397"/>
    <dbReference type="OMA" id="WGWQETK"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="200"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="258" mass="28534" checksum="7958449322C89955" modified="2008-01-15" version="1">MKTRSGILSGQRVEYFKGNSAIKAVLSPEYAKLKNVPAVTNEEEAERMLHSMLPFAFFLRVERGDAPPAGKDGPAPRPLQVNQMQMFDKDMYYVWLYEGMQLYQKLAGLGLIVALLGLVMFPLWPVFLRRGVYYLSLGVLALFGLLMVIAVIRLIIWLITIVVLPPGIWIFPNLFADVGVIESFIPLWGWDVPPEKKKVKRTKKKGKKHADVSEAAASATTIDDATVDNDADGEAANEGEVGASTSVSTESKNYADIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3D1</accession>
    <name>A8Q3D1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2364</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730568.1">
        <property type="nucleotide sequence ID" value="XM_001730516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3D1"/>
    <dbReference type="FunCoup" id="A8Q3D1">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3D1"/>
    <dbReference type="GeneID" id="5854875"/>
    <dbReference type="KEGG" id="mgl:MGL_2364"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2364"/>
    <dbReference type="InParanoid" id="A8Q3D1"/>
    <dbReference type="OMA" id="CLLHPPH"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000076">
        <property type="entry name" value="RNA polymerase II holoenzyme cyclin-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="155"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="306" mass="34789" checksum="926807ECC0204111" modified="2008-01-15" version="1">MAANFWSSTQCHTWLLSPGTTLKARAEDLKYASAIDVAALCAWCLNTISDLCVRLGAQQRVIATACMYFQRFYVKNSYVTTDPIVVLVTCVYLASKVEEAPIRIRIVCAEASKMMNERGYREMPNHVPLLAEMEYCLLEELEFDLVVFHIYHLLPNLCEVCLNACKISSQHSDTKDVMASLLQMAWYIANDMYRTHLPLEHPPYVLAVACVYLALSISPTLRESLKAKFHGAFDEASPDSDTIKFLASFNVSLPIVTRVIQDMLSQYQLWHTLAHPSSGSSLLTDHKTLLRRMYRMREDRCRAMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3E4</accession>
    <name>A8Q3E4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2372</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730576.1">
        <property type="nucleotide sequence ID" value="XM_001730524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3E4"/>
    <dbReference type="FunCoup" id="A8Q3E4">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3E4"/>
    <dbReference type="GeneID" id="5854883"/>
    <dbReference type="KEGG" id="mgl:MGL_2372"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2372"/>
    <dbReference type="InParanoid" id="A8Q3E4"/>
    <dbReference type="OMA" id="FEGPLAY"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="173"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="378" mass="43206" checksum="2B094758A5A57958" modified="2008-01-15" version="1">MKSSTAPAKPRSQMPSTSVVRGHVGQSQVRDRSGRISEYSSSDDKCPICKTDRYLSPRLRLLVSPCYHKMCESCIDRLFSLGPAACPECGQVVRKQQFSAQIFEDLQVEEEVNIRKRVSRLFNRRPEEFPTLRAYNDYLEEFEEITFNLVHKIDLEHTQTKLAQYEALNKSFIAQQQQQREQESIRQQQLDEASRQERMLRAQKVKEEQELEQREREAEEKAIVAELEKGRSIDDVMQEHEKRRQDRLAASKKRAMEERQRQKLFEERLHEAPVSARPKMSAAELEYIHQVIQSDYVGPFATLDDGSGLVAVREAPVSLGGIAASGSAGYVDPWLKPEFVTPIASAQNRAGGYDWQHQVWQRGILAVCDGLSLAPDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3J8</accession>
    <name>A8Q3J8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DHHA2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730630.1">
        <property type="nucleotide sequence ID" value="XM_001730578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3J8"/>
    <dbReference type="FunCoup" id="A8Q3J8">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3J8"/>
    <dbReference type="GeneID" id="5854937"/>
    <dbReference type="KEGG" id="mgl:MGL_2426"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2426"/>
    <dbReference type="InParanoid" id="A8Q3J8"/>
    <dbReference type="OMA" id="TMTIFFN"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="206"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="375" mass="42457" checksum="1EDD9F0192F5A08A" modified="2008-01-15" version="1">MQVLEEFWASRRATDASSATHFVVGNEAADLDSIACAIAFAFFERDQTWVPVVQARRDDLRLRPENLAVLERCGIEASSLCCLDELPTMSRDKHVVLVDHNQATKYFQQATIDRIFDHHKDEHQHLNARRVIYSPDDAGSCASVLTMHWRPDDVPTFVADLLYMAILLDTVNFNRRAGKAQTLDYDAQRCLAPHLSFPIEHQDALFHDLQRMKNDTSHLSTTDHLRRDYKQMTCAAAHGGCWTIGMASVTLPLRALTEAGGFYDDALAFAEEHQVDVLMVLAGYQDEQAAWRRELMLLASEANAKRGVQDLAEQLSSLQSHMVDLEPLDSVAHDARPDQKRDAYFAVAWNQKDLRATRKQFVPAIQEVCRHVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3K6</accession>
    <name>A8Q3K6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730637.1">
        <property type="nucleotide sequence ID" value="XM_001730585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3K6"/>
    <dbReference type="FunCoup" id="A8Q3K6">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3K6"/>
    <dbReference type="GeneID" id="5854944"/>
    <dbReference type="KEGG" id="mgl:MGL_2433"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2433"/>
    <dbReference type="InParanoid" id="A8Q3K6"/>
    <dbReference type="OMA" id="KFENTQF"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="420" mass="45950" checksum="138FEA5AE27516D4" modified="2008-01-15" version="1">MAGRSGILQLALCALTIYTMFLLWGLLQEKITSTVYRTGDAFDPFSVGERFEYGVLLNGVQALCSCLFASIYLMYRRRHQSVAGQGLLSKMGLDVLTPSGCEKALIARGKLNPGQSLQGLKRFISPLLLQYLLVSALQSTASWLSIVALRHLSFPAITLAKSSKLVPVLIMNVLLYRRQFAAYKYVVVGLVTLGVWMFMALGNKKASKQTHGNSALGMTLLVIHLLLDGTTNSTQDEVFATYGPFVSGTQMMLVMNAISASYMMTALLVPDGLGAYIIALVRQHLGSMLHPHWMAHMLLASSTVPSLSLTPQLVSSVQFLLRHPDAARDVLAYAMAGAAGQIAIFETLERFGSLTLVSITVTRKLFTMLLSIMVYKHQLRSLQWIGVVIVFVGLFIEMRAKQRQSASAPNVAVPQKAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q417</accession>
    <name>A8Q417_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2488</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730106.1">
        <property type="nucleotide sequence ID" value="XM_001730054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q417"/>
    <dbReference type="STRING" id="425265.A8Q417"/>
    <dbReference type="GeneID" id="5854413"/>
    <dbReference type="KEGG" id="mgl:MGL_2488"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2488"/>
    <dbReference type="InParanoid" id="A8Q417"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="171"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="257"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="319" mass="35422" checksum="299D6D8232B6C01C" modified="2008-01-15" version="1">MSSMSIHGKNDMKARGQGATALVNTTWLASQNRKAAPQPFQPRPLKSIVKNDPASSYPRAPLTAKHAAANVPSSVDKSVGRTTSMSNVRVPSASSAHTYGHSETGSSTRTPTVASTEPTARLDLGRYDGGLERDESKGRRETSSEADLLAMDSSMDGLQHQPTRPWSLSEFEIGRPLGKGKFGRVYLARTKTVTSARLGNQGYVVALKCVYKKELVENRVDLQLRREIEIQMNLRHPNVLRMFGYFHDQGRIFMMLEFAGRGELFKILSKLPDRRFDESTGAKYIGSKSLMLLQVIFTRSMSFIETLSQKTCLSVFVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4K7</accession>
    <name>A8Q4K7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_2558</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730176.1">
        <property type="nucleotide sequence ID" value="XM_001730124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4K7"/>
    <dbReference type="FunCoup" id="A8Q4K7">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4K7"/>
    <dbReference type="GeneID" id="5854483"/>
    <dbReference type="KEGG" id="mgl:MGL_2558"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2558"/>
    <dbReference type="InParanoid" id="A8Q4K7"/>
    <dbReference type="OMA" id="ICQETET"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP42962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="89" mass="9533" checksum="38E76590B39F5DA2" modified="2008-01-15" version="1">MQHPGGDEVLLTEAGNDATEPFEDVGHSEDAREQLKTFYIGKLADPENLPKRAGKASDLMAQNSGSSAYLLVVAAVVAVVAYFVLVRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4P7</accession>
    <name>A8Q4P7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2598</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730216.1">
        <property type="nucleotide sequence ID" value="XM_001730164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4P7"/>
    <dbReference type="STRING" id="425265.A8Q4P7"/>
    <dbReference type="GeneID" id="5854521"/>
    <dbReference type="KEGG" id="mgl:MGL_2598"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2598"/>
    <dbReference type="InParanoid" id="A8Q4P7"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="42"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="318" mass="33360" checksum="E85A7E74008B6AA1" modified="2008-01-15" version="1">MSAVPTPTTAAPAPAPAPAPAPATQQKTLKEVESELVAKRAPPAVSSDAMAAAAAQTEMPRPLTLGEVEAQLLKQRRSASALQSQAQSQAPQHPPASVPPGVPHAHSPRVRPQVAMPLQAVVHPPVSGAPLSVPPPGIPLPGMPPMNGVGMPVAAVAGAGPGTGVGGVAPQMHPAPPAPQPAEVQAAHLARMRAMLEACPPNVQTAILSLPPPIQFDSLEEIVRRYPSLLRGETGDAETAAHVLTSEAPSRMEEWRKTEEKRRSKAAKLAQLTKHNGVMSGADKDFITRIQISHLVTSDPYTDDFYAHVFFALAWRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4T6</accession>
    <name>A8Q4T6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730252.1">
        <property type="nucleotide sequence ID" value="XM_001730200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4T6"/>
    <dbReference type="STRING" id="425265.A8Q4T6"/>
    <dbReference type="GeneID" id="5854557"/>
    <dbReference type="KEGG" id="mgl:MGL_2634"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2634"/>
    <dbReference type="InParanoid" id="A8Q4T6"/>
    <dbReference type="OMA" id="VWWWSHA"/>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050376">
        <property type="entry name" value="Pterin-4-alpha-carb_dehyd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42805">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42805:SF1">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="135" mass="14930" checksum="AA9F2C413ADE54AF" modified="2008-01-15" version="1">MTTQWADQNCVPCSKKAIRELGLQRLTPDETQTKLQQLEPGWTLMPQPQIGSATTMLPNALQKVYKFRNFATASEFASAIGKEADAQGHHPAILLEWGSVGVWWWSHALEGLHDNDFIMASRTDRLAASAPGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q584</accession>
    <name>A8Q584_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730367.1">
        <property type="nucleotide sequence ID" value="XM_001730315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q584"/>
    <dbReference type="STRING" id="425265.A8Q584"/>
    <dbReference type="GeneID" id="5854672"/>
    <dbReference type="KEGG" id="mgl:MGL_2749"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2749"/>
    <dbReference type="InParanoid" id="A8Q584"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="112" mass="12205" checksum="C0F216AEC2288D0C" modified="2008-01-15" version="1">MGSITELEDSLNMLLKVMASAIAYLSRKSGHTPVNAQVPLTVLGNTEALPPETLEASRDELVQDLISQAKDVQRRIDALPSRDISEDEHVRGCCLVTLLIRIGQCRTDAFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q596</accession>
    <name>A8Q596_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730376.1">
        <property type="nucleotide sequence ID" value="XM_001730324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q596"/>
    <dbReference type="FunCoup" id="A8Q596">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q596"/>
    <dbReference type="GeneID" id="5854681"/>
    <dbReference type="KEGG" id="mgl:MGL_2758"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2758"/>
    <dbReference type="InParanoid" id="A8Q596"/>
    <dbReference type="OMA" id="WAPFVKT"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15112" checksum="084F7096533AC4B7" modified="2008-01-15" version="1">MPTWVDIVKTGAYKEQAPYDPDWWYIRAAALARHVYLHKSVGVGSLCKLHGGPKNRGFRPSHHSPASGAVQRKVLQSLEAIGVLEHSSKGGRIISQDGMRDLDRIAVAVLESQREEDEEDEDDDDDEDNDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5K5</accession>
    <name>A8Q5K5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729803.1">
        <property type="nucleotide sequence ID" value="XM_001729751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5K5"/>
    <dbReference type="FunCoup" id="A8Q5K5">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5K5"/>
    <dbReference type="GeneID" id="5854104"/>
    <dbReference type="KEGG" id="mgl:MGL_2789"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2789"/>
    <dbReference type="InParanoid" id="A8Q5K5"/>
    <dbReference type="OMA" id="AGTHSEW"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21978" checksum="AC7CEB027D5EBAF3" modified="2008-01-15" version="1">MLDEHICLAFAGLNADARILVDKARVECQSHRLTVEDPVTVDYITRHIAGIQQKYTQSGGMRPFGISTLIIGFNQNETQPRLYQTEPSGMFSAWKANAIGRSSKTVREFLEKNYKDSMSQDETIKLAVKSLLEVVQAGAKNIEIVVMTGHGELKALEQEEIESIVKQIESEQEAEAERRRTRLAATASAEASMYGGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5W3</accession>
    <name>A8Q5W3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729837.1">
        <property type="nucleotide sequence ID" value="XM_001729785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5W3"/>
    <dbReference type="FunCoup" id="A8Q5W3">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5W3"/>
    <dbReference type="GeneID" id="5854144"/>
    <dbReference type="KEGG" id="mgl:MGL_2823"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2823"/>
    <dbReference type="InParanoid" id="A8Q5W3"/>
    <dbReference type="OMA" id="TATKQMY"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="134"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="540" mass="59960" checksum="DF8CB2F6506C2D7C" modified="2008-01-15" version="1">MSGVFMLQNASPEVARARLLSFFTPSSVLSGPLVTPPPSAIETVTPAWSKPRIWSQHATASVCPKNKSALVIHSPAISISTTGTEATTSPQTHIEGPSYTSTSHLGYATQPPASIEELYSNAHECMHAPLTVPVGLVNQGNSCFASAVLQMLVFCRPLYMFLTQLRMMVPQDLSNSTPLLEAIFRFYSEIPVVSKQLYGLVEKSVDPILPDYIYDAMRLHKRFDLFQLGHQEDAEEFLSLILSTLHEEVVLVFARAMQRKKSSASLQQRAPKKSVAMGDPYAAYPPPMESDNSSDEEDILAMEVQRPPSPEQDEWLEVGQKGRTSLTRTSGNTDTHSPVTRMFDGKLRSTLSCPGAKTSVMVEPYRSLPLDIQSSHVHTIEDALRHITEPELISGVWSPQRNAYVDATKQVRIEALPPVLVLHLKRFVFDEFYGVQKSTKPIHFGMSLEISPDILSTPCRRACSLTKYALFGVVYHHGRLASGGHYTVAVRRQDDSGWIHIDDTYASQISAEEVMFTGHRSSTHNGQAYLLFYQKVPPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5W6</accession>
    <name>A8Q5W6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2824</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729838.1">
        <property type="nucleotide sequence ID" value="XM_001729786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5W6"/>
    <dbReference type="FunCoup" id="A8Q5W6">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5W6"/>
    <dbReference type="GeneID" id="5854145"/>
    <dbReference type="KEGG" id="mgl:MGL_2824"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2824"/>
    <dbReference type="InParanoid" id="A8Q5W6"/>
    <dbReference type="OMA" id="YHFDQGI"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="192"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="372"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="644"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="75313" checksum="59A306B6676C1AAE" modified="2008-01-15" version="1">MSDESLTHSLDALSIGSDFRSPQSRLMGESDAFSSQLPAPLERPSAFSPFPYSSVNDSTSKNGASRFHQLFNGGPSAADESNFMHKRPYDSALANAPLVGSSSVSRSNMFGSPAMFNPSSIQRAQSPFYSGPWSISPPSAAPFPVPIERANSPGNTSNLSAMMPPNPTPLRFGTNMTAPAASPTGEADIIPTAIVIKNIPFNIKREQLLHVIRDLGIPVPYAFNYHFDQGIFRGLAFANFHSPADANEVVAALNGLDVSGRKLRVEYKKVLQAGEKERIEKEKALKRMQLPNVNDKERKRDRASPSEASTIPSLGSLSTISPVAISPGIGGTPGLSGKDGLQRITPDGGKTSPYFSRLPVGEAQETSLDLNDASTMEVYSRVLAFKDDRMRDELAFSKSLTPAERRVVHLVARSFGLNHFTVGSGDDCYVMVTKSETSSQGLNSAPMDSRDLSPLLKDRFMTTNSDLSSKKSVPDMRRDAFQPESFGAGSPSSFHGLALPSSNLLPRKSNSSLREGLSAPSDPRFDSFSNFGSSPSSHNLFAYPVDTPSVPYITRPRSTDLDALEYAGLHANTLQGLHRSRSPLHRTHSPISPNVHSTPVTPLGTHAGPLDHPSTLFGILPNKLELPARPSVGPSESLLDISRVSSSPHLKPPSNEDQLNPANLTFTPSSSSQAPYSKETENVKNLVTPTITTSCSSDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q658</accession>
    <name>A8Q658_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729870.1">
        <property type="nucleotide sequence ID" value="XM_001729818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q658"/>
    <dbReference type="STRING" id="425265.A8Q658"/>
    <dbReference type="GeneID" id="5854177"/>
    <dbReference type="KEGG" id="mgl:MGL_2856"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2856"/>
    <dbReference type="InParanoid" id="A8Q658"/>
    <dbReference type="OMA" id="WNGHASS"/>
    <dbReference type="OrthoDB" id="3365060at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="10">
        <location>
            <begin position="115"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="327" mass="33837" checksum="BC6512FE8947AB1E" modified="2008-01-15" version="1">MECVKGSIFGSTSLRGSRPPMEDGAADRSMSRPPTSPPLAASLASSTAAAVTAVPSFDAMDDDDAPPQQTLHDMPQVQGRAFDSSMTSGMLSSSVGAADDSSSSVRMPVSGQASPLAHRSVLVYGFPPLLRSVVVEQFSALGGLESIDDVSINPAQEKTLRLVFHEPIQALQAVSQNGRTLAGTCMVGVRWENDAMHQQSLVGGLDAPLLGVSSGAAFDPNVAPPMASTAPATPVSQLRASSARHTAGTPAFGRPIDKVESPGSALAQPTKDTAKTSALQSLWNMCPSMWNGHASSSTKSVDASIEIGSKQKPTTLLGHLAEGLFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q684</accession>
    <name>A8Q684_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2880</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729894.1">
        <property type="nucleotide sequence ID" value="XM_001729842.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q684">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q684"/>
    <dbReference type="GeneID" id="5854201"/>
    <dbReference type="KEGG" id="mgl:MGL_2880"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2880"/>
    <dbReference type="InParanoid" id="A8Q684"/>
    <dbReference type="OMA" id="CPALDNM"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="583"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1033"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1336"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="794"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1050"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1342"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1358" mass="151961" checksum="C01F234CC62D554E" modified="2008-01-15" version="1">MTPARKMPPPITPGRTGARIHANTTTPIASASGTLGGAAAVAAPLPPVKRLVIHKLVLQDFKSYAGRQEIGPFHKSFSSIVGPNGSGKSNVIDALLFVFGWRANKMRQGRLSELIHNREGLPPPPYCAVEVWFRDIIDYPDTEKYDVVRGSRLILRRVAMRNNTSQYTLNGTKSSFTEITALLRDRGIDLDHKRFLILQGEVESIAQMPPKGKTEHEEGLLEYLEDLIGTSEYKEPIEEHAKAVDAASDARSEKMNRLKIVQRELDALEPRRKEAESFLRDQNELVCLQSRLWQSHMVDCRDHISRASESLAAVRHQIESEHAKHAEAQQASDSLRASHQAEVNACAEMETHVRDLTRAWESAEKLGIELNARHKMITGKRKKLISSLTESKSAVARARDAASMATSDISSVQREFGERESALVREESTLENICDRLKGTTREFSDAIEQKQKELAPWTAKISEHTAACEILQHERSWLTSHSEDTIQRVEDARVSLADLQRTMQMQTEEMESLQYEQRTLCDKMDEDRAQLAAMQDNERALRQKRDQARRAAEDAKHSLASTKSRGEVLQSLVRQAELGLLSGFYGRLGSLGTIDPRYDVAISTACPGLNNLVVENVATGQQCIEHLRKHNLGRANFVLLQNVQVKTDAMGPITTPENVPRLFDLVKPKDARFAPAFYHQLGDTLVARDLAQANRIAYGVKRWRVVTEDGQLIDKSGTMSGGGSRVMRGAISSTLHADVSPEQASRMEKEFSAAESMLQSHIQSLAHLTTLIERNEARLPAIQKKLALLDMDVQTSTQRISEAEDHLHEAQAQSEPNQDDLRRIKELDHQLHLHQDEIATLKSKSADIEQAIHALQEQILEAGGVELRAQQAKVQGIKDMMSLCAERLAKSEEQHAKAENDLKRYEKALKSGQEQLDLLDAELQTLEESRVAQASDLESAAARIEDMREALEDRIEKRDQLQAQLDEHDASLRAFRALRMELEQRLEDHEKTKSENEQRLQHWVKQHSQLVLIPVPRSEDDTSSSQLISDAHEERQHGGGNVAVKVEDGGGDNDDMEQEPINEKLSNNTNESETCDEEELADQLPTLTDDEARTVDKGRVQADMTRLEERLASSDVNLDVLEEFRHVEETFLARAKDLERVNEQRDQAQNKFEALRKERLERFMDGFTQISLKLKEMYQTITLGGNAELELVDSLDPFSEGIVFSVMPPKKTWKNISNLSGGEKTLSSLALVFALHAYKPTPLYVMDEIDAALDFRNVSIIANIIKERTRGAQFVVISLRNNMFELSSRLVGVYKTAHCTKSLTIENVDLHATSPLDSHAPPAFAAAAAVPYRHPPGGAMTSPTKSGGRTTSSVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6F9</accession>
    <name>A8Q6F9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729968.1">
        <property type="nucleotide sequence ID" value="XM_001729916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6F9"/>
    <dbReference type="STRING" id="425265.A8Q6F9"/>
    <dbReference type="GeneID" id="5854275"/>
    <dbReference type="KEGG" id="mgl:MGL_2954"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2954"/>
    <dbReference type="InParanoid" id="A8Q6F9"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="1">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="106" mass="11621" checksum="7A116A0D87816BFE" modified="2008-01-15" version="1">MTSLIDSSWERVDEFLPPGIAAEDDSWELVEDSTELVLLDLPHTKQTESSAWSQVPAAPGTSVVLTGLDTPMPLLKVGETVMQGTYDELLGSEIVLKLERTLLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6L2</accession>
    <name>A8Q6L2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2999</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730013.1">
        <property type="nucleotide sequence ID" value="XM_001729961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6L2"/>
    <dbReference type="STRING" id="425265.A8Q6L2"/>
    <dbReference type="GeneID" id="5854320"/>
    <dbReference type="KEGG" id="mgl:MGL_2999"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2999"/>
    <dbReference type="InParanoid" id="A8Q6L2"/>
    <dbReference type="OMA" id="VLHVAYD"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="11">
        <location>
            <begin position="769"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="984" mass="109788" checksum="087C1A67001D22AE" modified="2008-01-15" version="1">MKGNAVTCEYATVSLASQAKVRWRRYVAPRGVALDEIAEVAQTLQAALIASPKTREPAVLWLTHLRLPFYAVEGTDMPEALWMFVWSDTTLSVELENYLQALLLHSSGEYIVQQQHHPGSAAHAADPLPQSHTFFLRAVCNAIADRLHDGFNTRVAGGLLRLNPFSCEFQAPSLACYTTFRAYTSQHTLYVMSNTEYTQWRPFDLRITPADAVPRDVVLGETQVRMLPSLQRATLLSTCVETQAEPHMSNVLSVLNDSFLHLSNQDSSHVAVLRISIREPPPSLPVDASDMRTGVNPRTTLCTVLWPLALCLRDESSHTETTRTPWPLYSAAQLLDSETWHTNSDAAEPDVMSEAGPGLQQSPLCTIASERIAEPSHMQTPNKNSPLSLMQDNMEGVFSSIGQLTQDELSFFEMPTTLSAFIEPPNAHAQPVCDPMGSSNIPTPTSPTPMTCPDALTHKYDEHGKFFTPGGRWRSSDDVTRIGLSPRFSFTSPQSASGNMAAWTSISPMFQSDESNDDDETDFAGTPSIVQRSLCLTRLRSSTAYPEQKPTYSRVSETRAMRMRLAWTALYAANAQHSLNLPRHAEPVLTAQVQSEPLPIPSIFAGCQQSFVQIHITALPFWTQLGLQPVAGKRMIHAHLVLVDSTVPLESARAWLQALADQYSAQSLGTLTLGHVWQYKEGTWTHGSSPSLAKGHTVVILVYDDRRACERLYSAWPEPRADVTLLPVPQNDLLAYPIRQSLVWAAYEDPLHRVFQLAPRTFEVCHYLREKISFALAWPLQSSHDPLHQGAVLHVAYDRLAPVVRVVCTDDRAQRLVCRVWDASDAQTDILHAWEVICGVLADTFATWHVVIGRFSDMPAEEMQTWKFVISRKESFILSVGLLCLEPNAWPLIHTQPHAQPQVVYMADMPMALHTGQPLPVLRSAYMTHGVYAVHLLQSHDTYEMDAYFHDIVLHLYALECMTKARWPGLDVCLPWHFAILACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6S1</accession>
    <name>A8Q6S1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730056.1">
        <property type="nucleotide sequence ID" value="XM_001730004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6S1"/>
    <dbReference type="FunCoup" id="A8Q6S1">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6S1"/>
    <dbReference type="GeneID" id="5854363"/>
    <dbReference type="KEGG" id="mgl:MGL_3042"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3042"/>
    <dbReference type="InParanoid" id="A8Q6S1"/>
    <dbReference type="OMA" id="LPTIMFA"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="55018" checksum="D70981E53379724E" modified="2008-01-15" version="1">MVGHILLVISAIPPVLDNSDGALACFIIAIIIMGLGTGCFKSNCSVLIIDQIKIKEQTVVPLKSGERVIVDPALTTERLYLWFYLMINIGSFCGQIGMVYAEKWIGFWLAFLLPTLVFIIPIPVLWIGRKIYTVAPPDGSVLKNAVRVCALAIRKNWSWNPKTFLRLWKSPHYWDCAKPSLVPEHDRKSWMTYDDQWVDQLSCGAKACFIFLLFPLYWVCYNQISNNLIIQGGQMDIGSTPNEIPGTLDPIFIIVFVFVFNLAVYPLLDRMRVPFTPIKRITVGFFTACAAMIFSAVLQHYIYAKNPCGNRVGDDIVINGIDCSGTNANITVWVQAGSYGLVALSEIFAAVTSLEVAVLLAPTNMRSIIMAVSLFTTAFASAINEAFNPLSKNPLFVANYTVFACLSFVGGILFYLMFMGIDRNQEELNLVLQHSAKNAQDNNDTSVTHADFPSDSHTDLHVEKPTSTTDFRTDKPTTSTEAHDDVRFTVEEGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7I5</accession>
    <name>A8Q7I5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical phospholipase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729531.1">
        <property type="nucleotide sequence ID" value="XM_001729479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7I5"/>
    <dbReference type="STRING" id="425265.A8Q7I5"/>
    <dbReference type="GeneID" id="5853837"/>
    <dbReference type="KEGG" id="mgl:MGL_3075"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3075"/>
    <dbReference type="InParanoid" id="A8Q7I5"/>
    <dbReference type="OMA" id="LKPWHIN"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16014">
        <property type="entry name" value="PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728122" evidence="2">
        <location>
            <begin position="24"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="652" mass="73088" checksum="1F310828F9AA8189" modified="2008-01-15" version="1">MARFIQFFLSIAALCFGAAPATAVHDELKNIKHIVIFMQENRAFDHYFGTMAGVRGFQDPNVHISKHTGKDVFHQPVNSSMWDGDADQPSSYYPPKNVTELKPWHIPYQGGDYHERTQCMVAGTNDWRQNHNAWNGGEMDRWAMANTPFSLGYYRRDDIPIHYGIAGNFTIADHYYESIMSSTDPNRISLFSGSINVNTSVIGGGGLKVGGPVIDNNGDPRCLVADNKDFFSCRPLKWKTVPEYLYEKNITFQFYQDFDNFGDNTLVAFTQYKEAAKNKTEFAKRSVSFIGIDRFVEDAKKGTLPEVSYLVGPMQLSEHPPYTPKDGAYIQAKVANAVMNGKDWNSTVLFYSYDETGGLADHVVGPLPPKDAKGEWITDPYDKSKGKVPTGPGFRVPFYAVSPWTRNGGVFTEHAAHESQILFLEEWSKAVGKGFHTKEINPWRRAQFSNLVNMFDFSYHDSSVLDLGNVPEASKDPITHEYNGADVCALKFRTNVQPTVPYNNSEAQSLRVETGYKPVRGNLSEGHFLTFEANGKALSHKDQKKVGSADANKDHDAEDTRFVLWWQGKNPKDNSFLISNADKHNRMYITSSLDLSSKKKDAAHFSIVDLGNGKGHLITNTHSNLQLTLEKNGAVSMKESGSNEFKVYSVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7N5</accession>
    <name>A8Q7N5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729544.1">
        <property type="nucleotide sequence ID" value="XM_001729492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7N5"/>
    <dbReference type="STRING" id="425265.A8Q7N5"/>
    <dbReference type="GeneID" id="5853850"/>
    <dbReference type="KEGG" id="mgl:MGL_3088"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3088"/>
    <dbReference type="InParanoid" id="A8Q7N5"/>
    <dbReference type="OMA" id="FWEVESS"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="580"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="855" mass="94340" checksum="9A1245858CAFF628" modified="2008-01-15" version="1">MFLNCHTDSKGPRERATSSIQTEVDSRSSAEKQRRFASFNLDQSTIDSTPRPGLHTTRNPSDNQPRHVGSDERTSLQMSSGKKYPGQLCISPTQATDPYPFNRYLYFGYYPQDQSISFSTAFPPSEPSSYSQADVARTNVPERDSTSNEVLGTGSAIMAPYPIGVYYSMPVYQRSVCFPDPSTVPMVSYTFPSPSIQGTMATPMGHDPEHQAYPATDAVSPVPLGFDSRSPSDPMYLNTSSSMYPALPSPSASNAYGRYVYHDPRHFYNFSSGATMHPPHLIQPPVPVSPGYAVPSYERAPYSDKSHGFNSARRRRSTQPQVSNRPAPSSNTQKQKQRVKEVSTEPVTPSVSNESVLIPPPSVPTSSQLTDTVACASEKQERNAPAARNILGASSDNQVNGTRSIFVMWCGNVPSDATLEELWEFFSSIPENFSASVVSSGTAADEPNEATGPACVYETDNPAGILSIFIISRSSCAFVNYASREHLERACAYFHGRPLRTKSSCPRMVCRPRKLEDAEYAGVAAQRGKGVHTNWFRHQRKLEKERFLELGQSECVLEDAEERSFSSTNSSLLAHPYFSNRYFILKSRSADALVTALRTNVWCTQPHNEPVLDQAFRNSEQVTLFFSENFSGQFFGYAVMTSRPGRALPTTESLSQSDLSSDKDKVSQSLEVSGGPEPGHNEPHPISSAHVAHEAKDSVPENNRPSSFASDVSLTPSMDADNQVQEDLAVRAKLHNLRLDTEATASDLDSQSLRHRTQANGPSDASTPLRSGSADESSPLSPIHASRSLHVGQPFYIEWKTTTPLPFSEIHNLRNPWRDNRLIKVSRDGTELEPNVGKQLISVWQAYLQKETQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7S9</accession>
    <name>A8Q7S9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729565.1">
        <property type="nucleotide sequence ID" value="XM_001729513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7S9"/>
    <dbReference type="GeneID" id="5853871"/>
    <dbReference type="KEGG" id="mgl:MGL_3109"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3109"/>
    <dbReference type="InParanoid" id="A8Q7S9"/>
    <dbReference type="OMA" id="HEYMEGM"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="81"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20201" checksum="AA2BF230F1191013" modified="2008-01-15" version="1">MWVVRTRSMLQTSAVPKHEQYRNTLDAFVKIYRREGMAAFYRGLLPSLLGVFHVIVQFPLYEHFKSLTSEFRRGDPLSPSSILLCSGGSKMLASMVTYPHEVLRTRLQMVPTFSDQSGVAQRQYTSFMQTILSILRHEGISGFYRGMGVNLVRTVPNSGLTILTYEVIMHYFATHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7V6</accession>
    <name>A8Q7V6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3136</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729592.1">
        <property type="nucleotide sequence ID" value="XM_001729540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7V6"/>
    <dbReference type="FunCoup" id="A8Q7V6">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7V6"/>
    <dbReference type="GeneID" id="5853898"/>
    <dbReference type="KEGG" id="mgl:MGL_3136"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3136"/>
    <dbReference type="InParanoid" id="A8Q7V6"/>
    <dbReference type="OMA" id="MINEIYM"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="117"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21438" checksum="56E2E3201E12C8D1" modified="2008-01-15" version="1">MAFMAKTVSERTQPTQRQSIQENNFTAHVHARPAVDGISGVLVSDSEYPVRVAFSLLNKLLEEFLMKVPKSSWQAQAMDIASTGSIPSKGDGIVRTSDFPFAQDYLARYQDPRQADTILRVQQELDDTKIVLHNTIDSVLQRGEDLDKLVEKSGSLSQQSKMFYKSAKKVRMSVFMCGALRLFPYSCCGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7W4</accession>
    <name>A8Q7W4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydantoinase B/oxoprolinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729599.1">
        <property type="nucleotide sequence ID" value="XM_001729547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7W4"/>
    <dbReference type="STRING" id="425265.A8Q7W4"/>
    <dbReference type="GeneID" id="5853905"/>
    <dbReference type="KEGG" id="mgl:MGL_3143"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3143"/>
    <dbReference type="InParanoid" id="A8Q7W4"/>
    <dbReference type="OMA" id="QVGMTNT"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="591" mass="63652" checksum="8A984A6755097A91" modified="2008-01-15" version="1">MPSSGADPILLSLFANRFMAVAESMGRSLQQTSISTNIKERLDFSCAIFAADGSLIANAPHLPVHLGSMSFAVQYQAEHLHELGQGSFKRGDVVLANHPAAGGSHLPDITCITPVFAPDRDEIVFFTASRGHHADIGGILPGSMPPTSKTLFQEGAQIRSFKIVSEGVYDQKGLMHLLLTEPAKYPGCSGTRCFRDVESDLKAQIAANHKGIQLLNDLVDEWGLETVQSYMMHIRDNAEFSVRNLLRRVANTQKSTDLHAIDYMDDGSPIELHITINPSSGSAIFDFEGTGPEVNANHNCPKSVVYSAIIYALRCMVSEDIPLNQGCLAPIDVRIPEGSMLSPSDTAAVVGGNVLTSQRITDVVFRAFEAVAASQGDCNNLTFGTGGNDETGRLIEGFGYYETIAGGSGAGPSWHGTSGVHTHMTNTRITDPEIFERRYPVYLRQFGIREGSGGAGHFRGGNGVIRDIEFLEPSIQVSILSERRVYQPYGLCGGEPAASGLNLWIKQRREEDGDLVKPNDEGFVSPRVINLGGKSTAIFGLHDRIIVHTPGGGGYGTPSNESPPTASAPSRPNRLHQRGSVADWQARQLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8C5</accession>
    <name>A8Q8C5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3246</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729702.1">
        <property type="nucleotide sequence ID" value="XM_001729650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8C5"/>
    <dbReference type="FunCoup" id="A8Q8C5">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8C5"/>
    <dbReference type="GeneID" id="5854008"/>
    <dbReference type="KEGG" id="mgl:MGL_3246"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3246"/>
    <dbReference type="InParanoid" id="A8Q8C5"/>
    <dbReference type="OMA" id="DCCLYPR"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000040">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="215"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="518" mass="58250" checksum="4745D6A7F8262B95" modified="2008-01-15" version="1">MLACGPDVTVMIRKGDEGTYEPLSASGVKKAKKMYDMTIKKKQKAGEQAAQEAERAEQDRKKLEESKKIVIEPPSDAAPAKRIKICAGVQNRDVRVKVCGWVHRLRSQKDRMFLVLRDGTGYLQCVLQGALIQTYDALTLTLESSVELYGVIKTLPEGKTAPDNHELVVDYWTCVGKAPGGDDAIMNRVSENADPSILADNRHLVLRGETASAILRVRAAVLDGFRAEFASSGMLEVTPPCMVQTQVEGGATLFQFDYYGQKSFLTQSSQLYLETCLPALGDVYCVQESFRAEKSHTRRHLSEYTHLEIELAFVSFDDLLSHIEQDICGMVDRVLKDDKTRALIEQLNPGFQPPKRPFLRLNYKDAIAYLNEHNITNEHGEPHKIGDDIAEAAERKMTDQLGVPILLHSFPREIKAFYMKRVPGDEAFTESVDLLMPGVGEIVGGSMRMTGHDELLDAYKREGIDPSPYYWYTEQRKYGTCEHGGYGLGVERLLAWLTNRWTVRECSLYPRWTGRCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8H7</accession>
    <name>A8Q8H7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729729.1">
        <property type="nucleotide sequence ID" value="XM_001729677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8H7"/>
    <dbReference type="GeneID" id="5854035"/>
    <dbReference type="KEGG" id="mgl:MGL_3273"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3273"/>
    <dbReference type="InParanoid" id="A8Q8H7"/>
    <dbReference type="OMA" id="GPYQLYG"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="422" mass="44985" checksum="0F60A3693847FD20" modified="2008-01-15" version="1">MAAPVKYDVVLYGATGFTGSMAAQYLAAHPQQPRVAFAGRNEKKIRGVIEKLTDVSKERVESIGVIVASAEDLNSIKAMVAQTKAVINMVGPYALYGGFELAKAAAEAGASYVDLTGESSVYKRIKNELHDIAKQTHADIVPSSGFDSLPFDLTTYLAVQALHKSSGGKADVDYALCGYEFKGSLSGGTVASLVEQAKVSPITSSDAYDLAPIRGRQKAEAVRLRKLPQFNKYGAFTLLAPHNTGVTNRSWGLLQEAQDPASYGADFRYLEGQVAPGMISAYIISSLMLFIAWLLNNVSYAGDLLRKAVPQGTGASMEEQLKGFCNVRTLAYGKDGKSKAMATLSVKGDPGYLRTAMFISETALTLSLEKARLSKLGQQGGVLTPATAGGEVLAERLRKYGGVKIETKDVSNSTDLSKELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA45</accession>
    <name>A8QA45_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729137.1">
        <property type="nucleotide sequence ID" value="XM_001729085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA45"/>
    <dbReference type="STRING" id="425265.A8QA45"/>
    <dbReference type="GeneID" id="5853443"/>
    <dbReference type="KEGG" id="mgl:MGL_3604"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3604"/>
    <dbReference type="InParanoid" id="A8QA45"/>
    <dbReference type="OMA" id="WEPASTT"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="239"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="683" mass="74899" checksum="6FFEA4048CDA3AC9" modified="2008-01-15" version="1">MSSPSFVEKHWSDDAPIDTDSETIGGFDGGRRSYVSVDTEASAEQVSSSEQDEPQTLQVRDRGPASLESQRYYHLVHADDMTPLQQPRYSRHIKGKLSTEKYHASSVNPSGHRESDFDEGVSDEAAEEFGPRGKSSGSSRSRSPSAYHMDPDATVTEYRPFSSYTIQGRKNERSPRLVSSKNSMASTHRLPLRANAPHLRDPYHVDERSPLLQMHGRGSEYQQTFMTPKSVQERDQSQKSTFCQTWFNTVNALIGVGILSMPLVFSQCGWLGGFMLFMLCGGVTNWSGKLLARILRRDPKLQTYVDIGTYALGPGVRVWISVLFCMEMFMVAVALIILFGDSLAVLVYGYRQEPSPATMILFKVVGFVVAMPTLFLPLSFLSPISLLGLSSILFLFAVLLLDGLMKRSAPGSLWEPASTTWMPKWSGMGLGFGLLMSGYSAHPIIPSLYRDMQDPSKFDRMLNVAYATTAFLYMAVASTGYLMFGDQVSDEVSTDLARTPGMPAALTTACVCLLVINPVTKFGLALRPVQGLFESLLGVSQSMSEQESDMSHPACNERGSNFFQSNSHIQQAAAHSLEVVTHPSLIKRYASMLGSRLCRLILGLVLSGLVLMTAIVFPSLERVMSFLGACLAFSTCILGPFVANMAVFASEQSGLSILVDCVILSVSFLLCILGTISSIRSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA63</accession>
    <name>A8QA63_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="6" type="ORF">MGL_3622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729155.1">
        <property type="nucleotide sequence ID" value="XM_001729103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA63"/>
    <dbReference type="FunCoup" id="A8QA63">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA63"/>
    <dbReference type="GeneID" id="5853461"/>
    <dbReference type="KEGG" id="mgl:MGL_3622"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3622"/>
    <dbReference type="InParanoid" id="A8QA63"/>
    <dbReference type="OMA" id="ILAPRTW"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="350" mass="38657" checksum="AC488600F913207B" modified="2008-01-15" version="1">MHVMRQPIFRMLHTASSVDPNDIAHFSRLADQWWDESGEFAPLHRMNRVRIEFMQQKLEEVRGWDAAVAEAMGYDTIPTPLNTPDFLSGSRMLDVGCGGGLLVESAARLGACVTGVDASSENIRIASLHASKDPGLRMRTSEEDAQDASLAYLATSAETLRNAGRTFDIVTAMEVVEHVNQPAEFLRCLGSLVKPGGHLFMSTMSRTMFSYFLTIFLAENVLQVVTPGTHRHSQYIHPFEMVDFFRELGWIPSDASLLANRPRLKDGSPIAPVPPRLLFETRGTMYVPGLGRWILAPPSVADASARGEASRALSSACLPSFLGGGMRPTELCNYFFWIRRPTHTPSLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAC0</accession>
    <name>A8QAC0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729212.1">
        <property type="nucleotide sequence ID" value="XM_001729160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAC0"/>
    <dbReference type="STRING" id="425265.A8QAC0"/>
    <dbReference type="GeneID" id="5853518"/>
    <dbReference type="KEGG" id="mgl:MGL_3679"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3679"/>
    <dbReference type="InParanoid" id="A8QAC0"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="323" mass="36330" checksum="C47994EEDDE4B213" modified="2008-01-15" version="1">MGGPSIGDIRSRLVRLAAFAMTQKDRTSQLGYADSREAVFHLMSHRLPLHGSHKEVKQEWMEIIEGKHRLWRGIDPDKRECIRGFLVLFQSEVLHRAHRNFNFRGGCIGNFFLASMQRFFRSIQSAIFMFAAVSEIPFVLSSCDVLPAVNTNKTTTIAADLKDGSLLVGQCEISHPSDEGTRHRRLSSHSRSMNRRVSELQDSVFGFGPQSMTQNQLDQLRLGSQMESHSAARAGSSALSIDDSDHSEEDQVLDDDPREITELTESSGNIEYVAKEDAPPLPSPIDRTFYSRLQAGVFYVNVCNSFFLPRRFLQGMFLTAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAI0</accession>
    <name>A8QAI0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3739</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729272.1">
        <property type="nucleotide sequence ID" value="XM_001729220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAI0"/>
    <dbReference type="FunCoup" id="A8QAI0">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAI0"/>
    <dbReference type="GeneID" id="5853578"/>
    <dbReference type="KEGG" id="mgl:MGL_3739"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3739"/>
    <dbReference type="InParanoid" id="A8QAI0"/>
    <dbReference type="OMA" id="PQWDMIT"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000014">
        <property type="entry name" value="Cation/H+ exchanger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="945"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1025"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1056"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="12">
        <location>
            <begin position="256"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="572"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="915"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="799"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="878"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="878"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120305" checksum="5A963A4CDA0E2991" modified="2008-01-15" version="1">MAPAAREPPAPKANAQPVSPRSSARPSSQLFTRRATVAGPSTSHITDSSDRSSSRDGPLDEPDRGEALIRQRIRERKREKWLKHHDYQTDVPHSFLSDGGNSQVAPSFSTPAHVATSSIRDHGKSPDVSRWAHLPRSSDRLRPGLDDDPTLQTHSDIFGTDTALSVEDEDKYANEHGTDDGHHDDGDGEYFDGEDDDDEDLDFTVKDRQDALNIEHPFGLPIWKPALYKKSRSIQRTADNALKCTPGLRTSRSSMLGNVVWLLLFGVWISLICFFLSTLLYCVPRGGFMYAHTLYGLGTYILWPFGNYIEAECSHADGHRHGPCRLPTVHEHEIKDEEDENLEHVDTQPNSECSPLTAHGNSALYGGVQNDEEDGHLSEEERILQERKLYHYVFDENGNDIGVPSRIGGIIAYGLVYGLVLFPVLGVVCVLCWGLVVTIPMAKLTWVLIKNLASQPLALHFRSPLQIDTRVLKVKNSSDAQSMLHPGHMAPLLKRKHRKKGTSKRRSVILVCSYRAMGLEYFKYTVGGVNIVFINTIPFIFLTQVMFYVLRPYCRSHGITSGLWATLSNDALIFIMSLASVLPLSYFIGMAVASISTQSSIGMGAVINATFGSIIELILYSIALTDGKASLVEGSIIGSILAAVLLMPGLSMCSGATRLKEQSFNSRSAGVTSTMLIMAIIGILTPTIFYQIYGKFELDCSGCPDDVTDVKDRFRCEKCSYEHISPLADPFFQTNVKGLIYACAVILLLAYAIGLWFSLRTHASQIWNSTPNIMQPEPLPPPLHRASVYKRLFPPHEDAAHLPLHHDGQNHTEQDESSSRVENQTANHTSIPATDGSHGGSSETQVHKSSKPRPSDDILLDAAARMYQYLFNQHKVDDPVQGNEDHLHAQQPDANGNGVSQGGHDAPSWNRSTSLSVLLGCTVMYAIIAEIIVDLVDVVIDGSGLSPKFIGVTLFALVPNTTEFMNAMSFAMNGNIALSLEIGSAYALQVCLIQIPVLVGFSAIYNSSYKQPIGDMALHSFTLIFPRWDIISILFSIFLLTYTYNEARSNYHRGSVLILAYLVLIVGFFYAPSVDLDDPAQEKGRRVFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAI1</accession>
    <name>A8QAI1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_3740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729273.1">
        <property type="nucleotide sequence ID" value="XM_001729221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAI1"/>
    <dbReference type="FunCoup" id="A8QAI1">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAI1"/>
    <dbReference type="GeneID" id="5853579"/>
    <dbReference type="KEGG" id="mgl:MGL_3740"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3740"/>
    <dbReference type="InParanoid" id="A8QAI1"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP42059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="367" mass="39450" checksum="FD124A0BBEF2968C" modified="2008-01-15" version="1">MVRDEKVKVGVLGATGTVGQRFILQLSSHPEFELHVLGASSSSAGKPYHEAVAGRWKQVRPIPSSIRNMMVQECEPSAFAECGVVFSGLDSGPAGPVEAAFRAANLRVFSNAKNYRRDPLCPLIVPLVNPSHLEIIPHQRASQSPQLDRGFIVTNANCSTTGVVVPLKALEAAFGALDIVMVQTMQAISGSGYPGVSSLDILDNVVPYISGEEEKIEWETSKILGGLKDNNTAFDLHEQSPIRVSAQCNRVPVIDGHLACVSVSFKKQPPPSPEQVAKALSSYECEAQLLGCHSAPVQAITVHMESDRPQPRLDREWQDGAGVNVGRIRPCPVLDIKFVSLVNNVMLGAATSSVLNAEIALKRGYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAJ8</accession>
    <name>A8QAJ8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729290.1">
        <property type="nucleotide sequence ID" value="XM_001729238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAJ8"/>
    <dbReference type="FunCoup" id="A8QAJ8">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAJ8"/>
    <dbReference type="GeneID" id="5853596"/>
    <dbReference type="KEGG" id="mgl:MGL_3757"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3757"/>
    <dbReference type="InParanoid" id="A8QAJ8"/>
    <dbReference type="OMA" id="EPHEAWH"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="209"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="299"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="2">
        <location>
            <begin position="737"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="912" mass="101269" checksum="F6A716E59DA5FE81" modified="2008-01-15" version="1">MYPVARLLYVYTKVRGYKLISRFLPHKVQDIVPLLHQLECMHASRPPWELIYVTLLWLSLVVLVPFPLQRGTGASILERVERVTRLYVSRSGKERDAASIVLGRLYRRRDTPSVLFTSFLTWSEQQLTETARMSSFLATGTLQTLCEILKNADAPLVQEHYDAIRHVLATFRTLEQGRNGLVIRYIVKLEGRLALHLLSTAIKMRAGVIDANLETHIDTLMQALAYSDSRVRYSAAKGLARISACLPAALRQQIVVALLDMLAEHILPDTMPSAALSSDETFDFQTCEKLRETDLHAVSECTWHGVCLALAEHVRRTCVPSNMYVRVIYWVLTALAFDVRRATGSTGTSVRDASCYVLWSLARARDASSTLGPFAPAIAQYLVVSITLDREVSIRRASSAAFQEWVGRTSCIPHGIDILRKTDFAAVGPLRHAYLDCAPYIATWPVYRGVLLQHMMRVSLTHWDAAIRVLGAEAIGKIVSMDKSAASSIMQHLMARVQKTKDQTLVHGALLALVSLARVDSVLAPEASRAALEVSASMLSLSTQSAAAVLEAACRLVALAALPLQVQHVSDAYRGNVSKLLHMALARPEIAVQDAAVDAIEAWKDDEQVAHAYVRRALDTWTTLNDDMQRAAAKVMGVVPVRPEEQSALLCACLDRQAPFSSKLRVETRCAAAASLARLCVQPTEVVRVLQQGLHDMTTDQRGDVGSWVRLACMDSLGHVFCDWDVDVPALESAWVDMVGMLMERIDAVRVKAGHIVRRVADIHATALPNGESILAVVAEPEELRNAPYAFSVLVPLMSLERYRASLLYTLSRTIGSRSEMALREAGQALVDWALTVPDECVHDILVLLHHRAQAHVRENRVFVPILQTILLLLDWDVHKRKSEDVNRMYVTRARVEGREGVDFWIPGGLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAK5</accession>
    <name>A8QAK5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3764</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729297.1">
        <property type="nucleotide sequence ID" value="XM_001729245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAK5"/>
    <dbReference type="STRING" id="425265.A8QAK5"/>
    <dbReference type="GeneID" id="5853603"/>
    <dbReference type="KEGG" id="mgl:MGL_3764"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3764"/>
    <dbReference type="InParanoid" id="A8QAK5"/>
    <dbReference type="OMA" id="EMALDGH"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000192">
        <property type="entry name" value="CTD small phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="10">
        <location>
            <begin position="458"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="281"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="633" mass="67189" checksum="4E2E1E7C1E5DF2C1" modified="2008-01-15" version="1">MSDNLSYSPLGGPRSSVVQSSHSAGGVPAAATRSLSTRSIRPARPVSGAAQTNITLGSPLNASNSPPSSSATSALVSSDSAASSVYMDPSSTAPAPLFSGPATYAHSPNYQTSTAADEVPVGTGNGILTRVPQNHWGSSSPPPLGVASNTQQQPLPQQRPSFHAPPQSNSHFYPHNSMAAQVPAVPGPQPLLPESFSQAPASTSGPAVTTTSSTSGQPLSSSVPASTQLSVKSNSTYSKSQTPALSKPAPSTPSHPPKNADNRPRGFRKFLAMMTCSSSSSTVEMALDGHQNTSPTQPANPSSQPRTSLPPPTTQPSVVKEPTSMPGPAPAGSNPSPNPSPRTSLQPRPYSGLQPETAEPHSDTGHTQSMLRVPSVMNRNSVATSTATSHSSETDDINQDVITQVPQNGSMMSMGMSDPELEQEMFAEEQRLIQQGGTGIPVDENGQPCPLLAQVSALDASRKCLVLDLDETLVHSSFKMVPNADFVVPVEIEGIVHNVYVIKRPGVDEFLRLMGQIYEVVIFTASLNKYADPVIDILDMHRVVRHRLFRESCYNHYGSYVKDLSQLGRPLHDTIILDNSPASYVFHPTNAVPVSSWFNDPHDTELTDLCPFLEDLCFVDDVRIVLDGFIDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAL2</accession>
    <name>A8QAL2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728983.1">
        <property type="nucleotide sequence ID" value="XM_001728931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAL2"/>
    <dbReference type="GeneID" id="5853290"/>
    <dbReference type="KEGG" id="mgl:MGL_3771"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3771"/>
    <dbReference type="InParanoid" id="A8QAL2"/>
    <dbReference type="OMA" id="WWASGNA"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="196" mass="21987" checksum="2DFF53C539DB64D4" modified="2008-01-15" version="1">MTVLLTVPERTATRLCALAKQDDVPVELREQIRTSLRSKALDQDAPADMGVAWQHVVIPHHILVAVARWARPRHETDLCLDQLVRGARVYVEPRPIYRRPPELEASLEAIRLEQEKQAYENMTATSTQPAQVSLRVRKPVMTVSAKEERAAWRDARAHMSALMNILLSMGAIATAVWWGAGSASTLWKCCMQGMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAL4</accession>
    <name>A8QAL4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728985.1">
        <property type="nucleotide sequence ID" value="XM_001728933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAL4"/>
    <dbReference type="FunCoup" id="A8QAL4">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAL4"/>
    <dbReference type="GeneID" id="5853292"/>
    <dbReference type="KEGG" id="mgl:MGL_3773"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3773"/>
    <dbReference type="InParanoid" id="A8QAL4"/>
    <dbReference type="OMA" id="NCEKGVG"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="87"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="805"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1145" mass="127092" checksum="94D1F3C42E5BA1C7" modified="2008-01-15" version="1">MDARHALAHTPLKSGENQAQFKTPLRTPLSVLEQKSSTPITPFEAIESQKENVQPRARGRSAHALSTTLSMHHKERQETLAAQRREWEERVNGEENQDSDDPLEAWCSYVKWCIDNYPEGKSSESGIVPLLERVTRLFRESEQYQNDSRYLRLWILYAQHTDVPRDVFQFLLSNEIGTKLASLYEELANVLESHEVYDEADDTYKLGIARRASPLDRLKRRYNEYQARILALPESSSSSSSGDGGPTTYANALAAAMARAGRSVLGVKTGRGAESVPTNVLGTHQPLSSSSGSMRPNARTMQVYCDDENDMGPPKSSSGSHAWTNIGTAAARRKENQTATHSLKPLTPGGRVAQTPRSQARALEVFCDSDEDASPRRTPRRDDVFQRHVCTESDKLRKNPFLHYDSATLEPPAAPKSQATIVPPPAPPAVTMPASRHASRERTHAAPNKKRIVSSKPVRERHAVPLQRLYPDADLTAAVQDKARPIPPTREMCLEELYAQHRSIPTACASDPWAFLDAWQGRWMPEPVAVTAGTASTAGARRAPSPTLVTKAAILEVDHMFNGESDSNSEDDDDDDDDDDESETDDDDVRYPVLSNTQDENVGIQPTPIRPRVDRQPFGATPQQTPRARNIARDEDDEDDVNDGEPSSLSASPRIMPRTPFQPLTPITERTERTEHTEGSVRTEHTDRMEPNERTVHSVCASPQTNADVLASTADQPFGGLYASPATLDIPNPCSPADPDIVTALLSNLRCPLASRPGYIDEAQMTTTYLPTLTSRVAGAQRSQSSQRRSSVSTACDLNVADMQLSVCMRLGEGGFGSVFLAQDMNESVPLAGETTASYEDVDADDVDELERRQMLALKIESPPNPWEFYILDELRRRLPAPLQASVVGARRFVACANESLLLLEYASKGTLLELVNHASTAGVGNVLAHGGGVEEVLAMFFVIELCRVVEGMHNAGLLHGDLKIDNCMIRADDVDEWTSTYAADGSGGWSAKGVTLIDFGRAVDMRCFVAEQRFLADWQPGAQDCVEMREMRPWTYQADYYGLASIAYCLLFGKYMETTSYVNEDGQKTYKIQQTLRRYWQTDLWTRFFDLLLNPTHAPMWPVTPLLAELRHDMEVWLAAHSFHAGKNLKGLLKKVEIWALRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAS4</accession>
    <name>A8QAS4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NSUN5/RCM1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729033.1">
        <property type="nucleotide sequence ID" value="XM_001728981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAS4"/>
    <dbReference type="STRING" id="425265.A8QAS4"/>
    <dbReference type="GeneID" id="5853340"/>
    <dbReference type="KEGG" id="mgl:MGL_3821"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3821"/>
    <dbReference type="InParanoid" id="A8QAS4"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NSUN5/RCM1 N-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="212" mass="23811" checksum="1B335E6F372547E9" modified="2008-01-15" version="1">MADFYVRAARTMQDVLAHRGSIKAISAGNGDLNHAKRIMALVVNTLSYRTVLLHILKQVDMAKKEPKWFGGASPLNRKASDASSNAPGMADCVMLVLLHDLLFTSRGIQAAKAWPPRVCMEKYKSQLHAELVRLQIRQGKKSAEELRSGAAERRLAARIPRWCRINTLKIREIDAIQQLETAGFELVNNTILTKEYVHSTLMEDRSFLALIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB21</accession>
    <name>A8QB21_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729084.1">
        <property type="nucleotide sequence ID" value="XM_001729032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB21"/>
    <dbReference type="STRING" id="425265.A8QB21"/>
    <dbReference type="GeneID" id="5853391"/>
    <dbReference type="KEGG" id="mgl:MGL_3872"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3872"/>
    <dbReference type="InParanoid" id="A8QB21"/>
    <dbReference type="OMA" id="NNEYMEL"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="2">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="248" mass="27521" checksum="CC95C32FC03DDABC" modified="2008-01-15" version="1">MADRSVAWDELGKLEMNRRTDDGKSDSQGPGVYSASDAAANAMLEQRKLAQQVPVPTSDIHVRETLRRYDEPVTLFGEHEADRRARLLGVLIARHGKNAVHLSHAPVADASEENDDDEDEEFFTEGSTALLLARRRIAMYSLSRAKRRLSQQHFEAQSSLGDMAALRKSVLDPLKSYTSLGSQVAGERPVSIVRFSPDSSILATGCWSGKAALWEMPNASPLGTLHGTWRGSNRTQWLTRQLKHMKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD02</accession>
    <name>A8QD02_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728735.1">
        <property type="nucleotide sequence ID" value="XM_001728683.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD02"/>
    <dbReference type="GeneID" id="5853061"/>
    <dbReference type="KEGG" id="mgl:MGL_4070"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4070"/>
    <dbReference type="InParanoid" id="A8QD02"/>
    <dbReference type="OMA" id="HERMESD"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="93"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="864"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="930"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1312"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="523"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="974"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1241"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1321"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1472" mass="166268" checksum="7CF0B2DEBD9638E7" modified="2008-01-15" version="1">MNDAGASGNEHLGLSKVHHSSLLPPISDLMDTSALSSSRTSRSARSLNSVNGLGMDAASSSAYTAPQTPSYLHSADADTSNVSASSVALLDDLLVTYSLLEAEPYQALSLEQVAELRRKQHKLSTSLKSMQERISLEKKMRGATHMLHAYKPSSTAKTVGAASTHEDPATQRDDLHAKMLEVSSAMERTDQVMQQFIEASDGLHDAQNRLLSPHVAVLRAPPHAERPPPTMDMSTSSSSRGMRTPHTWTHGFLTPRGSTSRLARSFNTHTGSPSSQRGTPSRNENVHALSEESPGSDEHGGLMDEVERLQAHRRGLSMQLASTGKRQKDLRKRLSLLCAQHTELGDFLQEDEADNEPTDRSATSPALAEQEHRINEMQSEHDEQKLQIILQFEQERRHLEEQHANELRMASAAAEQRGLKRAEELLSSLQEQRQKHDTELKKLNLSMEETQQHYANEIHHMHELLERAQQRHDQDRRDASVSFEDIRQRHAKELDSANAALEEAQSFHAVEQTHANVSQEAREQQHTKELDQMRHSLRQAEQTLAAQQARMDAAMEELKSQYTKELDDVKQALKHANEEHARELDGSRETTDKAQQQLLAEQNRMNESVDELKRLHATELGDVNTALMAAQQQLATERNHMSVTRDELKKQYTSELEEARLALERMQAAHAKELEETRLTLADTQEQLATERNDASVAIHELKKQHENELEEARRAVEQARSDLLMELDEARAALATAQQQLATERNDANASIDELKRQHENELEEARQAVEQARSDLMIELDEARVALATAQQQLATQRNHANVSIDELKKQHDKELEGLRLALHQTQEEHANELEASRTAHDNAQQQLATERNHLRVSMDGLKKQHDDTQEALEKARSGSERARDFHAKELEDIQGALDAMQQQLATERNDMQVAMDELRQQHAKELESTRAAMDESQRRHSEETQGMRMSFERGHRLQETELNETRQALQDARDQHAKERENTHSYLEDAQQRRAKELNQANHALQETQLLQAKNQHQTQELCDVHERQEQTQKALFDTQEERVHERMESDAAHKQTAKSLSDELTRIQAELLAHQERESELLVKHESELARRDAEHADTLSHMRASHADAVDQLNAGHAEKIGKLHTQHNDLLHTLRSEPRSSAHMDTLRSEYEQRFMELKRQHAIEKQELEDQHAKSSAALQARVAQLESEHATLQPSPNTSASRDRNDMRNQPSAVPTLSRRLHMMFGGGESTEEPASAPSSVPASGSGSADTDEAASNTPDATRSTERELRAQLAAEREQKDLVARRLEEVMVLYRTALRDRTSDKPLPVASEGTVTNEANNRTGPAADRREPANESESSAAVQPAETREAAAAGPPSPSMEEPLIPHTPEPHTPTTPEVPDTPRRLTRLETYIDNASTPTHRTERRTDPRARILEMELDKHRRAAEQSRFAYEQLKLRYDVDIASTARERELVQRWIPGLARCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD03</accession>
    <name>A8QD03_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum vesicle transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_4071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728736.1">
        <property type="nucleotide sequence ID" value="XM_001728684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD03"/>
    <dbReference type="FunCoup" id="A8QD03">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD03"/>
    <dbReference type="GeneID" id="5853062"/>
    <dbReference type="KEGG" id="mgl:MGL_4071"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4071"/>
    <dbReference type="InParanoid" id="A8QD03"/>
    <dbReference type="OMA" id="QRHEGCR"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="145"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48441" checksum="6BFC5CE8A88D8B19" modified="2008-01-15" version="1">MGPGAFFGQLRGLDAFGRMSDDVRIRTNVGALLTLTSALMILVLIVSEFLDYRRVQTSPRLEVDLSRGERLAVQFNVTFPRIPCYLLSLDVVDVVGETQMDVHHDVERRRLDETGKPVSEEVIRELESEAKRVIAERGPDYCGDCYGADPPEGGCCNSCDAVREAYMLHNWSFTSPDDIEQCAQEHWSEHVREQNHEGCNIAGEVRVNKVVGNLHFIPGRTFHRNDIHTHDLVPYLHGTGDDVHHFGHKIHRFSFGMEDEFAIERTSRGRRQGPLKNRMGIKNALEGRSAKTLSSNYMFQYFLKVVPVEVHKLNGHEMSTYQYSATSYERNLEDFDRGGQMSGHIVRMIEGIPGVYFNYEISPLRVIQTEWHHSIWHLVSNLFALIGGIVTVAGLIDGAIYRSRRTFNIVRGYGDDSEGLSMEAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD05</accession>
    <name>A8QD05_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_4073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728738.1">
        <property type="nucleotide sequence ID" value="XM_001728686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD05"/>
    <dbReference type="STRING" id="425265.A8QD05"/>
    <dbReference type="GeneID" id="5853109"/>
    <dbReference type="KEGG" id="mgl:MGL_4073"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4073"/>
    <dbReference type="InParanoid" id="A8QD05"/>
    <dbReference type="OMA" id="ADECEAR"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="408"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="501" mass="56542" checksum="6C7E29DE1B0AC5D9" modified="2008-01-15" version="1">MEREGALIPLSDQLLLAQTVHQDGKVPPDWDCISRRILAHPCMKGSSRMQLDPSHGNSLSQMFSAQACEQVWTTLVKTHVPSEPSRMDRGVQLALAQRLYAARLEELLRHIQEKESDFRSLHQRIQDLREGKLDAELKHDPRFSESTQRAVTEEAQDETHKTKHDAPPHTNRESMHTEDVEMAQEDIPVEPKAGPESETVPDSDAGPEPSQETMPASSQDIQPPPESPTRRESWKASEAAPESDRKRTSDPMKVDDGPDKDDDLQVEQDLLGDTKEAPTSRTPHDTTAEETRSTLTPRAATTTYSTRSRRQSLSHSRPRSRSRSRSQSQGQAQEPGLVPEHPAREESDSAFHTPTPPSSPGPAEVSEPRTQAARHANDNTHDKLSDAERDKNRRRMMQLLLMLHNQVSNHTHANLFHQPIKEVDAPDYYTVVKQPMDLKLIKQRIKEGLIASSVELRCAFSLMYANALMYNQPGTEVHRMANEMRLATEEILDEFDRTPRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD31</accession>
    <name>ERB1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ERB1</name>
        <name type="ORF">MGL_4099</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="EDP41550" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41550.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728764.1">
        <property type="nucleotide sequence ID" value="XM_001728712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD31"/>
    <dbReference type="SMR" id="A8QD31"/>
    <dbReference type="FunCoup" id="A8QD31">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD31"/>
    <dbReference type="GeneID" id="5853105"/>
    <dbReference type="KEGG" id="mgl:MGL_4099"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4099"/>
    <dbReference type="InParanoid" id="A8QD31"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000576">
        <property type="entry name" value="Ribosome biogenesis protein ERB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000370434" description="Ribosome biogenesis protein ERB1">
        <location>
            <begin position="1"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="509"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="559"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="694"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="735"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="778"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="833"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="864" mass="97424" checksum="DCC280A8ADCDCE32" modified="2009-05-05" version="2">MAVDKGRRPVPPERRAQGRKRAEPGDVTIRETRTRPVHTPEPEPELLAKDGILELEDDDDNDDDDDDDDDDKSNHHDGAPKNEDDMEAFPELVSGKDKDDDGDEDEEEDDEDEDEDASDDEAFDSDDLENWDEEADAKYGDADLSDDDDVKEGDAALERMIARARVKPDESERTTNKLGIDTGVAARFYDESRNDDGSKRGRVVQSHVTGMPKVEYPPIEPEYDSDSSTEDVPNRIGQVPLSWYDDLPHIGYDINGRRVLRPAQGDELDKFLDSVEGEGDGWFSAHDKTSGQDVKLTDEELDIIQRLERAQIPVEAYDPYEPATDWFTQHQQTTPLTARPEPKRRFVPSKWEHKKIMKIVRAIRQGRIVAHAPGRERPAFYNLWSDADEARADHPMHMPAPKLPLPSHVESYNPPAEYLFGDDEKAEWEAAEPEDRKLPFLPAKYAALRLVPGYDQALHERFQRCLDLYMAPRMRRKRLDIDDPDQLLPKLPAPRDLRPFPTHTDVVYAHAPWRIRTVSIDPSGAWLLTGPDDGHVRLWDAALGRCVATWDMNAGVARADRSPVYCVQWCPNRTFGIAAAVSVGRVTLLAPPQCGKTMYEASLAHLTTPHAAEDAATAQWTRASEADRAAGVCVRIDVRNNKHASLVPKYVRWHARGDYFATVSPEAAGEAVLIHQVSKHRSQAPFRRTRRAGNSAMAVQCVCFHPSRPWLFVATQRYVRVYDLVQQSLVKTLQPGVRWISSLDVHPSGDHVIIGSYDRRVLWFDLDLSERPYKALRYHSRAVRAVAYHPRFPLFASAADDGTVHVYHGTVYSDLLQNALLVPLKILRGHAVQDALGVLSIAWHPTLPWLVSAGADGDARLWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD80</accession>
    <name>A8QD80_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4148</name>
        <name evidence="5" type="ORF">MGL_4154</name>
        <name evidence="6" type="ORF">MGL_4160</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
            <strain evidence="4">CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728669.1">
        <property type="nucleotide sequence ID" value="XM_001728617.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728675.1">
        <property type="nucleotide sequence ID" value="XM_001728623.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728681.1">
        <property type="nucleotide sequence ID" value="XM_001728629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD80"/>
    <dbReference type="FunCoup" id="A8QD80">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD80"/>
    <dbReference type="GeneID" id="5852975"/>
    <dbReference type="GeneID" id="5852985"/>
    <dbReference type="GeneID" id="5853022"/>
    <dbReference type="KEGG" id="mgl:MGL_4148"/>
    <dbReference type="KEGG" id="mgl:MGL_4154"/>
    <dbReference type="KEGG" id="mgl:MGL_4160"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4148"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4154"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4160"/>
    <dbReference type="InParanoid" id="A8QD80"/>
    <dbReference type="OMA" id="CILESIM"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="348" mass="38393" checksum="03948A698F6DF6B4" modified="2008-01-15" version="1">MTTSNPIIAVTGATGFVGAHVVRDALARGYRVRSVVRSEKKGDELLRSMPGPSHSLAFVSDIRNKDELKQAFKNVKIVQHVASPYTMAFDDPVSEMLEPAIKGTMSVLEAANEENVEHVLITSSFAAINCFEKGGSIRDYTYTEADWNPATYDIARTSSKAYTYCASKALAEKAAWEYVREAQPSFALTTFNPPGIVGPIAHPLERLEDLNTSCANVWHLVSGSCDEVPPTFLPQTVDVRDVSKALVDAMSNPATRGERFALCGYYVDMQVVVDYLRKTFPERRDAIPAGNPGTRNQPGPIARLDASKAERVLGITWTPWEKTYGDLVKQLLELEEKFKAERSKMPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD84</accession>
    <name>A8QD84_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_4152</name>
        <name evidence="10" type="ORF">MGL_4158</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
            <strain evidence="9">CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728673.1">
        <property type="nucleotide sequence ID" value="XM_001728621.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728679.1">
        <property type="nucleotide sequence ID" value="XM_001728627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD84"/>
    <dbReference type="FunCoup" id="A8QD84">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="GeneID" id="5852969"/>
    <dbReference type="GeneID" id="5852977"/>
    <dbReference type="KEGG" id="mgl:MGL_4152"/>
    <dbReference type="KEGG" id="mgl:MGL_4158"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4152"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4158"/>
    <dbReference type="InParanoid" id="A8QD84"/>
    <dbReference type="OMA" id="NTFHEVG"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="542" mass="58495" checksum="882493A2EC532ECF" modified="2008-01-15" version="1">MRVNLDWKSKAPEAPQQNHNDPYIPTMEFKKDASPSQMPPENASDSTISSKVGVHTVGPWRKWSILFFICYAQFWDIVNVTAPTIALPTIARNLNMTASQKPWIVSAYALSFAGLLLLSGRLADMLGPKRTFIFGYFVLGISAIIAGVSPNAIMHFVFRAIQGIGAALTIPSGMSLIATHFQGKLFSIAFGIFAAAGCIGNVLGVIIGGVIAAKIDWRWIYYITAICTLPAGIASIFVCVHIAPGKPFSLKGLDVPGVFLATSAVILITFAFSGASSFGWVTATILVPLILGVLLFIVFIYVEHKVKDPVVPPSLFSVEFLVFVGIAFSLYFWFNSLVYQVTMVFEYVFEWSPLSTAVHFIPLGMTGLVASFSSGFLIKFVPVRYIMPVCQALMVGGALLLSFVRQSHDYARLVIPGFLIGNAGMACCFAPVNISLMELCPRGMEGVVGAVFNSAVQVGSGVGIAILALASDSIANSHEQNGMDSTKAQAIGLGQSFYILVAFCGLLVMMLLVTVVFRTPRSKDVDTNETSLQKLEPEFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD97</accession>
    <name>A8QD97_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728686.1">
        <property type="nucleotide sequence ID" value="XM_001728634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD97"/>
    <dbReference type="STRING" id="425265.A8QD97"/>
    <dbReference type="GeneID" id="5853026"/>
    <dbReference type="KEGG" id="mgl:MGL_4165"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4165"/>
    <dbReference type="InParanoid" id="A8QD97"/>
    <dbReference type="OMA" id="HWEEVKT"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="45373" checksum="84F825FE3A8DAEE3" modified="2008-01-15" version="1">MESYYLPSQSDAVTLSDTSSVSTSLAPSAVGEEEFEDAETDDDDDTIEEESIISMPRARGPPSTSTLDPPSPGIARGLGQGPLGKSGSNIPSSMLGNSPTTPLGPSLHTLSSESSLNGPLPKDPAPTSAIPTSAFTPSSRRGLEFRGGASFFKNLRKKKDSDEPPPHEEVGGTRLNQLSPSHPETAPVAKPLPILATTQSPPGQVDKTPAPVPLGAVTPRARQTGSARPGGASIASSQPQRDSARIRPAPMPPRMPGVRRVLVKGVSPRTLQALLFYMYTNQVHFVSIPHMPPHGHKNSLHEEALSHLGNGSKQNPALWPPAFSNKAAYCLGKQLDLHDLAVRAFEHISMNLSVRSVLADLLSPFGDRFSDVQRVHLDFITQHWEEVKTRPDFVPIVENLAQGQYPKSSASLFQLFSKLSVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQX8</accession>
    <name>A8PQX8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732759.1">
        <property type="nucleotide sequence ID" value="XM_001732707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQX8"/>
    <dbReference type="GeneID" id="5857065"/>
    <dbReference type="KEGG" id="mgl:MGL_0534"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0534"/>
    <dbReference type="InParanoid" id="A8PQX8"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727048" description="Peptidase A1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="70"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="380" mass="42337" checksum="45778BB564ADF794" modified="2008-01-15" version="1">MRCNVFFLALAAVPSLSLALSINLEQRGKLLSSDEQVEYARRRADSLVRRARDVEHTATYDLWQDGPYAWAAQLDVGANKERVKLFIDTTYPNIVMETDAYDMKNSSSAKNTGKKGTAEFFTLGAPFSGDIYTDTVRYGNLTSESQMFLAVNKSVVFIREPRGIFGLGPKSNNAFTKQDFNNDTSKTFFGKLKDTKQLAKNVYQLTIQLGGGKLTMGEIDDSQYEGKLAEFDMSRDYLGVWGQVNGQEARYMAFDSGSGYTMAPAADAKRFLSSLEGVEVVEVPELGQVKGFYQCDSPPPSIRFKFGDLEVPLSKRIMKITPVHAEPTKCLIPIMGYDKVKDLGDKTWIVGTTLLEHVSLIYDGDANKIRIGRQSMNMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR26</accession>
    <name>A8PR26_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732807.1">
        <property type="nucleotide sequence ID" value="XM_001732755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR26"/>
    <dbReference type="STRING" id="425265.A8PR26"/>
    <dbReference type="GeneID" id="5857113"/>
    <dbReference type="KEGG" id="mgl:MGL_0582"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0582"/>
    <dbReference type="InParanoid" id="A8PR26"/>
    <dbReference type="OMA" id="DTLHICA"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34653" checksum="B867A14103E3D8C1" modified="2008-01-15" version="1">MKYGQKSKRTKKVSETDERVLILGASTLDGLGAEFLRQYLERGARQIVIVGRRKQALDHVRHTMLKQTEGRGKRHPHAQVYVVPTELTETEGVIKLRDFVIQNLYGLDTLHIVFGVTSILPILGVANVDPCNVNASGQATAFLHASREGLDQIAQTVQHSSDGNLKGTAIVLGAMLPILQTTSANPAVITIGSVAGLVPAPTRAVYCASKSSQHFLIRSVELECEAQAGTPVPGSDKRRARVNFLLVAPGPIKNSFVATYAVDATTGPRDNRERALEVPDVVRGTLRRVDAEQWGILVIPTHAFVGSLLAQFNATYVPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR41</accession>
    <name>A8PR41_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732822.1">
        <property type="nucleotide sequence ID" value="XM_001732770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR41"/>
    <dbReference type="FunCoup" id="A8PR41">
        <property type="interactions" value="433"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR41"/>
    <dbReference type="GeneID" id="5857128"/>
    <dbReference type="KEGG" id="mgl:MGL_0597"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0597"/>
    <dbReference type="InParanoid" id="A8PR41"/>
    <dbReference type="OMA" id="YRRRDQE"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="143" mass="16840" checksum="3CC37D84FEC8B6AD" modified="2008-01-15" version="1">MIISKENRRTIYTTLFQEGVLVAPKNFEIKHPIMDVPNLEVIKAMQSLTSKGYVHTQFSWQWFYYVLTDEGLEYLREYLHLPSEIVPNTHKQPARPQRAMMGDRDGFRGGRGGGDREYRRRGDFDKKDDVPSGDFRPRFGRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRE9</accession>
    <name>A8PRE9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732262.1">
        <property type="nucleotide sequence ID" value="XM_001732210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRE9"/>
    <dbReference type="STRING" id="425265.A8PRE9"/>
    <dbReference type="GeneID" id="5856568"/>
    <dbReference type="KEGG" id="mgl:MGL_0037"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0037"/>
    <dbReference type="InParanoid" id="A8PRE9"/>
    <dbReference type="OMA" id="LWSYLYH"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="205"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="702" mass="79830" checksum="9E27C0929D8A4B4B" modified="2008-01-15" version="1">MSDDELSDLEDLESNLKDIDPTMKSETLVSAVRSLPGTQITPPSHLILPLEARDILNMETFSPIMQESFTRCMYQKEDVFKLMDVYFTHLNLLRHPIPKDIITQALSGIYTSNGIINQENLTQFSLISAILAVTTVFLLVSHPEYLRDLNLDISRFNFDASRRLSNASKIACGTSQGLNREDTNTIFTYVVLSRYFFVTGSLTRSWACVVDMVRLSFSLGLHRDGAEYGLDEITCEHRRVIWSIVYSSSHIYCLGYGRPPLINDDLADTRSPQPKTPMQDIPTEIRHLFDDVDPPHLLSINKVRFHLTKFISVLSFELHSVNKSFSYAKVLELHNNFGKFVSELPFYFQMSFQNGSAVMSCECDAYFPFLRAQRSHLWFDLSFFTLSLHCPYLLRMLKKGQSRQRYMTSYDTCMESVKRSLSMRRELLKSEQQESGPRMNRTTVLAFRWFNTTVVAGILLLLTPMGSDVDILRSGMQEFIDWRLSSQHTGNEPENLTDVNTIRAFLEQDMKRRAQSDALNELESSSTSSPELKRKRLRDDDEVSKPTSANDAKESTDTECSPSIIPPPANHNLQTDIWPSNGLPFNMPFESVETSSLWPDWQPNMETDQSSQHESSGPFLYDMPGMPFDLSSSSANTSLPSLNLGGMFRFPQVAPYSGMSQRGTVPYWSMEGGNTTPNVSAQALDFDFAKNDQDAQDLLNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRI2</accession>
    <name>A8PRI2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional coregulator that functions together with transcription factor HSF1. Positively regulates the expression of laccase LAC1 during glucose starvation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732283.1">
        <property type="nucleotide sequence ID" value="XM_001732231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRI2"/>
    <dbReference type="FunCoup" id="A8PRI2">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRI2"/>
    <dbReference type="GeneID" id="5856589"/>
    <dbReference type="KEGG" id="mgl:MGL_0058"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0058"/>
    <dbReference type="InParanoid" id="A8PRI2"/>
    <dbReference type="OMA" id="AYTKNQD"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="70041" checksum="DEC8850F992B753D" modified="2008-01-15" version="1">MTKAVGIDLGTTYSCVAVWQNDRVEVIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFADTEVQSDMKHWPFAVVDRSGKPAIKVEYKGEEKVFTPEEISSMVLLKMRETAEAYLGSDVKDAVVTVPAYFNDSQRQATKDAGVIAGLNVMRIINEPTAAAIAYGLDKKDDREKNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFKRKNKKDLTSNARALRRLRTASERAKRTLSSAAQTTIEIDSLFEGIDFYTSITRARFEELCGDLFSHTIDPVEKVLRDSKIDKGSVHEVVLVGGSTRIPRVQKLLRDFFNGREPNKSINPDEAVAYGAAVQAAILTGDTSEKTQDLLLLDVAPLSMGIETAGGVFTPLIKRNTTVPTKKSEVFSTYADNQPGVLIQVYEGERARTKDNNLLGKFELSGIPPAPRGVPQIEVTFDVDANAILNVSAADKTTGRSEKITITNDKGRLSKEEIERMVADAEKYKAEDDAAAERIKAKNGLESYAYNLRNSLNEEAFASKLDASDKDSLKKAIDETIEWLDNTQEGSIDEYQDKQKELEGIANPIMQKAYSAAGGAGGFPGGGAAPGGGATGGGDEGPQVEEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRY4</accession>
    <name>A8PRY4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732380.1">
        <property type="nucleotide sequence ID" value="XM_001732328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRY4"/>
    <dbReference type="FunCoup" id="A8PRY4">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRY4"/>
    <dbReference type="GeneID" id="5856686"/>
    <dbReference type="KEGG" id="mgl:MGL_0155"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0155"/>
    <dbReference type="InParanoid" id="A8PRY4"/>
    <dbReference type="OMA" id="LMKFLTA"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="60867" checksum="1FA40AAC85F4740C" modified="2008-01-15" version="1">MSDHYDVLVLGTGVRESVLSAALSRAGKRVLHVDPHTYYGSEWASLTLSELSQWASTHANADISFPREPCEPGAIPETYKSVDRHYSIALRPVLLPARGPMIEALIRSNVASYATFRLLGRIGVWDGEHLERVPKSKSDIFRDRRISLADKRKLMRFLQSAVEPDAPLPDSSVSVSRYLTETMGLGQQLERAVTYGVALCWDAMESSASAIDRTRRSLRGLGRYGDAAFLVGQFGGAGELAQGFCRASAVHGGVFILGHEVLSLKHACDSNNAWTLRVAGIEETFTADQVAAPREFMCENASWEDEQAMKSLSDTSSLSSSPVYEHVAVVITDAPIDWAAHMPLDDDEVAPETALVVFPPDAFGPSSNEHAVIVLGQGEGTFACPKGQYVYYLSTYGPTGTSARTCLHRAVRRLHTLLTTEAPFIAEFYCSHTLSETQEASIPAYVDTSAQLVRTAGGPAGRTSLCIGDDASQVRAQQAVPNLTETLDLSVEAAEQAFWRLVGEQHKQAAYQAAHDRSHQHDPSEYQGRGGVEPEAPKEATVVEVEFFAPRPTEDDEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS45</accession>
    <name>A8PS45_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732416.1">
        <property type="nucleotide sequence ID" value="XM_001732364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS45"/>
    <dbReference type="FunCoup" id="A8PS45">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS45"/>
    <dbReference type="GeneID" id="5856722"/>
    <dbReference type="KEGG" id="mgl:MGL_0191"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0191"/>
    <dbReference type="InParanoid" id="A8PS45"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="4">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="329" mass="36787" checksum="E50CB174550D698F" modified="2008-01-15" version="1">MSRRNRYGDDAPELAPILHSYGRALLEHIIATSGALGGGPVPNAEPAESISLPKNKDSCFEFRNDVSEEDSDSASNPVALGKRKANASEEESEPQQPDDPGQEEESENEQEQEEDDDMGVAFTVLDLSRVIFEKILHGSVTQSPESLSKGKHPAKPELKLITGEVWGETELQIELAEVRNDLGDIGLETGAYMHRLTKENFEQASVDYEASLNLLAPLIPPYARRLSDAHLRLGLALEFHPEQSRRKLAKDYINRAADVLQRRLDQISHINEHRDAPPEKHVSDADAIWQLDEDQIRREEKDVQEMLQDLRVKVSDAHAEHDVTDSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSD2</accession>
    <name>A8PSD2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732461.1">
        <property type="nucleotide sequence ID" value="XM_001732409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSD2"/>
    <dbReference type="STRING" id="425265.A8PSD2"/>
    <dbReference type="GeneID" id="5856767"/>
    <dbReference type="KEGG" id="mgl:MGL_0236"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0236"/>
    <dbReference type="InParanoid" id="A8PSD2"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="183" mass="19811" checksum="971EA6923A500FA8" modified="2008-01-15" version="1">MGWWTTKSSPQVAEPSGAGNIAGNDDQFQRSLDVPDEEPDPTQNRIIVPFSTLLVVSAMSLGFASGMMNGARHTALVYLAENAHKRPTTVQGWYFYNKTKYYRMILGGFRHGGSTSLRLAGWVAGWSLLDVLAEDARSYLAARSDGSFANSFESRVLQKLGHWSDGALAGFLTGLVGAISCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSP2</accession>
    <name>A8PSP2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketopantoate reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732517.1">
        <property type="nucleotide sequence ID" value="XM_001732465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSP2"/>
    <dbReference type="STRING" id="425265.A8PSP2"/>
    <dbReference type="GeneID" id="5856823"/>
    <dbReference type="KEGG" id="mgl:MGL_0292"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0292"/>
    <dbReference type="InParanoid" id="A8PSP2"/>
    <dbReference type="OMA" id="DIQPARW"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF43">
        <property type="entry name" value="KETOPANTOATE REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="1">
        <location>
            <begin position="164"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="356" mass="39695" checksum="8FE807D18F617D3E" modified="2008-01-15" version="1">MHVVSDKFGEETAWRPTRVIRTADDLDSSITLDYVVCSCKCLPDVVPNSEVMRPFLTKNLARKPTHLPTVLLLQNGIDIEHESYERLVKSDPPLASSIVSANTWVPATLREGGSRMEHGLLEVLSMGVYPAPLDAPVPAETQASLELLLQIALRGGSSASITNDITAERWRKVLWNISWGGVTVLARRPLLEMLQVEMLPYTIGSVRGIMLEMLAVARASGLGQDRLPASIIDQTMRQTMTNSPAQFRLPTSPDMKLHVKRSHNFPSNFKPSILVDLDRERPMELEPIFVNILRRARRMGVDTPRLDLIATALKPSQLLFVRRQQNQDPDALMMQEGIYNLSSFHSVSGNAPVSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSW6</accession>
    <name>A8PSW6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732553.1">
        <property type="nucleotide sequence ID" value="XM_001732501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSW6"/>
    <dbReference type="STRING" id="425265.A8PSW6"/>
    <dbReference type="GeneID" id="5856859"/>
    <dbReference type="KEGG" id="mgl:MGL_0328"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0328"/>
    <dbReference type="InParanoid" id="A8PSW6"/>
    <dbReference type="OMA" id="TWGPLAQ"/>
    <dbReference type="OrthoDB" id="2504896at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="934" mass="102607" checksum="E7A13AE5336863CF" modified="2008-01-15" version="1">MAESETPRHDDHVSQSEAKPAASEGYRHDAHVTTTTNSSSSTGANAGEGAYGSGGPSASATTTHHHHKPRFSALNINQRFLQSATAATAPKPALASAPPPPADESRTGPSPRLVTAMPGRMSAAQYHHHHHHHPVTDASRHKEAPRDAPAAPRMPWANVNKRAPMMPTVSSQDFPTAKEVMEAERKAEERAAAHAAEEHARQQAMKEELERFRGTELMSHDHWDELEEESEDEMDDVVEFGDGTQYKISEVEEEQAKHAPPVQEPSPPPAPRVPAWGPTHRPASLLRRPEPPASSVTAHASSQPLPHSHPRAPLHAHHHLHAQPHHPPSTVAAPPPPPPVSTWGPLAQRHSTLTGKPMPKLEPTPPPPPKEDPKAIEAEQQNEMLTAAERARRRREEDERAREAERERARHKAAQIEEQMLAAERAKEEEREQERRREQQAREEQTRLRMEREQKAKQEAERSEASETGTWRRTTPLPKSLCTPPALAHDAPTATVTATEAGEGGKRTVATKHATAHKHSPAAGSPRTREGRELWHQPPEAHSHPETPPPPEPVTTRAELLFDDAPVWHKFPVRCPSRPHKSRPPSAAAKQRRMPNDSYALIQCIEPPADVLAGTYTCWTSVDTLFEPVTKTRASRGKPHVHLRRPPAPPASTSFFSSERQTFPAVHPIDETAFFQKHMRAIDSLPVDELFAQENDCLKDAQHEPRCHEPASLLPRCSCKLRVNLPKARSWHASTSTLTPLPSSSSASAVPMLGLTYGGRLLGQDTFSPHFSTDRLDIHAPGTWGTSSLSFPIVGSTAHESTWHHPLKRMWSQASPASMPVRGTKNSLRDIADDPVPMPLSSHLADWDDHAEGTIAASASSWAPTYRPSYLVAPPSSLTAMATSSPPSHPLPLPHTQARPQPQPQPQTLSLATDSDPGGLLPGDYTDFVLSDTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSZ7</accession>
    <name>A8PSZ7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732568.1">
        <property type="nucleotide sequence ID" value="XM_001732516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSZ7"/>
    <dbReference type="STRING" id="425265.A8PSZ7"/>
    <dbReference type="GeneID" id="5856874"/>
    <dbReference type="KEGG" id="mgl:MGL_0343"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0343"/>
    <dbReference type="InParanoid" id="A8PSZ7"/>
    <dbReference type="OMA" id="RRTERIH"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="2">
        <location>
            <begin position="192"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="995" mass="109695" checksum="A7052A1A67FD2158" modified="2008-01-15" version="1">MPPHDAASLTMDAALIEVISALRASLAPRGIKLMVVLLCDPIMFAQGIDARVAHLRRASGLDARGALFVLSSGAKSELSSFVTSLVKASEVLTSDYYREHARHVRRNRARYPPPPSVAQPILQVAMKAGLCSAQSTMLNAAGWHIRTHYKLGALAELQGDMAESHSMYAEAYKTLMQQYLPYPTVVLPRTRRWAEAKVLADTLSFKLIKLFLYDMKKLAARVQFRQHNLHITRLCTRWGITDQTHEYWAWLAKQYTFMADLLDEKKLVPARHGFDVPLVRYQAAVCQMERARCTTRLDSSSREARVDHTALIVPELDRAYKVLFQQRRLRLAHLVAVRLALTLAETQPKRALNYLTRTLQWYRRDPWHELSYALVLEALACAIRCKDVNLITRMEHECRIPVPPCLVSKRTHMLKDVPSDSSWWSAHSDSSTNIQLGTEVGSRTIYARAAFARSLATAPAADMPCQVVICLPFDSPVDELHPLSVQVYLAGQDAPTAEKLVSVAQAEADSGNSNVRALDLGEQKATMCVDAGHSNFPHQAASSVACFSLRRAQPLIVNLRFSTDVPGMYEVHRVECVFMEHGQNVHLLCDIDRRSPSVWTLPNGSCIPLPATQKPHALRVRAPTYDVHVPPIMACGQIAPLSLISPNDAILPPGIRLSVSPYKGDNDAAIIDVCGNAHAELELTSAASGGDVVEDGHESGWDGLHASTSGQPKTHDSSRTTCASTSAPSPIWLRAPQEPCAAMEVLLLQPTGASRRTERIHRVVKVVPSFLCKAQIRWGGAAQQDGVLLLNMTYEGPLTVQVKRVHVETAPSLGVSVDPILGYMPNETWYTGDRAAWAARLCAQAPQGTGAANLVITWRSIGEPNSPEHVTRRPLPELGSPALQHVDVRVSAPSCSMLAAALPVQVSFINTSDEHIADVQFTIESTPDWIVSGMMRHSVSMLLPCEERLVSLELWPQRAGIWKLPNMNATQIQASNSALSLHVHKVPNDIEITPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT98</accession>
    <name>A8PT98_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0390</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732615.1">
        <property type="nucleotide sequence ID" value="XM_001732563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT98"/>
    <dbReference type="FunCoup" id="A8PT98">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT98"/>
    <dbReference type="GeneID" id="5856921"/>
    <dbReference type="KEGG" id="mgl:MGL_0390"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0390"/>
    <dbReference type="InParanoid" id="A8PT98"/>
    <dbReference type="OMA" id="GWYHIPQ"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="115"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="551"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP45401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="682" mass="76885" checksum="981E5CAA9379E84A" modified="2008-01-15" version="1">MSGDVRARFGEHILQDDYVAKKRAEYDASGPYHHSVVHGLVNEDLLKRARNEIVEELHFTEKETDIYKVNQTGDLANLDGLSEEEAGRLKSLMELRNAIYSDEFRDWIRRVTGCGPLSAKKKDMSINDYRHGCHLLNHDDVISTRRVSYILYLPDPAEPWQPEWGGALELYPVKEAHVPDDVPSHIVPPHWNQFSFFEVQPGHSFHSVEEVVHPTMSRLSLSGWFHRLQPDEPGFSPEEEERELRAEKEFSSVGSLTSKKFMSTFDEYAEDKYGTPPLPGTGLSSEHTRFLAHFLNPAYLTAKIQATLFEKFGDDSHLLLSDFLRKDIAENIERVLRTKDEDDGFVWWHGEKEQRVGFDAVRIQPHGVGTNRARTPSDEDRRWILAGPPHRERFATLQSACTPSDAPVIDYAANPPSPFVPMPTSPADLLHVLTHQLFPSAAFRHIIANMTQLIPIAARPIRARRFRPGLDYTLARSDDETTCWAALNRRLSIRRGPKGLAGKRKASGTSQVVSKGVMSKKDRDMLQGMWDRGDIGGWECYLAPHEGEEDPAVYQSAASRRAQREMNEGAKASDETLASEKKADEDVVQEDDQDEEFEDMDEDDDDDDDDDFDGVLLNVTPSFNSLNIVLRDEGVMRFVKYLGASAGGSRWDIAAEYTVGAAEMEEDEQGSKGGESSKQEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTL2</accession>
    <name>A8PTL2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732667.1">
        <property type="nucleotide sequence ID" value="XM_001732615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTL2"/>
    <dbReference type="GeneID" id="5856973"/>
    <dbReference type="KEGG" id="mgl:MGL_0442"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0442"/>
    <dbReference type="InParanoid" id="A8PTL2"/>
    <dbReference type="OMA" id="PEFFWIG"/>
    <dbReference type="OrthoDB" id="2555434at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646">
        <property type="entry name" value="YALI0F00814P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="139" mass="16110" checksum="83D436EC1843BF5E" modified="2008-01-15" version="1">MSREEHERSRYTAAQRTFDGAYMRTALSQLTFSLTVIKIFQPEFFWIGLMNCVLAVGLIITAVLRHRMTMRYKEKVFTMIEERRKASRNMGTSDATASHLNPETYTFLPHFQTAGHIVVFVMLISICVEVIIIYLLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTQ9</accession>
    <name>A8PTQ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732689.1">
        <property type="nucleotide sequence ID" value="XM_001732637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTQ9"/>
    <dbReference type="GeneID" id="5856995"/>
    <dbReference type="KEGG" id="mgl:MGL_0464"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0464"/>
    <dbReference type="InParanoid" id="A8PTQ9"/>
    <dbReference type="OMA" id="WHEPDAS"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="670" mass="73188" checksum="A1AD0A4E28DCD0EE" modified="2008-01-15" version="1">MWLLYAHYDGEHAPMSARVLHSGKSLKVGRKADLVDLLIPVGRISRWSGTLQIEAVPLSYVSQGGARARVTWTMRTGSKSGSFIESFRGRNRIEQRIQAETPVELTDQSRICLVSGVYAELRWLSFSLSVYRVPSLDSEDVRRTAALLGIHVTSVQKQLSAASTHLVVSCIRPSKEQLLALVYGIPVVSEAYVQALFGAGMAPAWHEPDASGFVPPSDPNLARDAQIPREQLTPRPERRHIYADAIVCMWIPKPSRRFLDLAELAEAAGAFVHVHDLSKEHVSDALTARQVLAKCKEQEVVCDAKRRMYVITEDAPVVDQACQTLKLPLLPDGMWAIPRGILDVQKWATMVRPYEPDSAQQESDATCDVTSWMDDLSGVPDVNVTTSEDMQPVQASHTSSPLVPSTNAASTLEPASSSRSSDSNPQQRVSTSRATRLSADDALAPLASQHTNRPGTLPRRAPRRSYLLDELLGVPRDEQQSARPAGPASVASSSPSQSDGERRSAKFRQMLDSSQSVFDKPVGTGLMSNESNLDRGDEAAHEARSHAPNETEAATVPDSDSEGGLPVPEPHAEWEQALVSAPASDSASRSSCTTASAPPPSSWNHIERPSFMQVRIEPMARPSHSHRRNFKKFRRTNTCAPHRVPVVLNLLDAERAASSDAVLFLGDDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU02</accession>
    <name>A8PU02_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732731.1">
        <property type="nucleotide sequence ID" value="XM_001732679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU02"/>
    <dbReference type="STRING" id="425265.A8PU02"/>
    <dbReference type="GeneID" id="5857037"/>
    <dbReference type="KEGG" id="mgl:MGL_0506"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0506"/>
    <dbReference type="InParanoid" id="A8PU02"/>
    <dbReference type="OMA" id="GMMNIAC"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="384"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="625" mass="67764" checksum="4E149726E79D90C8" modified="2008-01-15" version="1">MDVPAGPVLPGPNDERSRSPWKRKYGLRMVASISQLADNVLTMRSFHDVSRRDHFDRGPGTPDVILNQAQRPGSSFQGSSLLRGMSIPKEVSGRQESQSQYPSSSLPSFSPNGHCVSGESHCMPANEVQGVQLVMPSARRASAMILNDSSPPLSPVNDGRPRCNSGSMANHMTSPISSPEAALRTHNGTNQPFSPFFFDEGVARGAMADTNVKAKKHDHSWADFWPTLSTRPSPPSSLDSNAPSLTWSLSSHEDENTEPCALHVATQPKFQFGLGILGRAFTSSAQERADIDPSSQSITWEKIAPHAAKVVLLGITFLLATFMLGLAMSTLPLHMPTHLAQLTLSEIRDMCQNLRDYAASSNGAMIHVFLVLTLFFCWKQAFCVPGSLITNIIYGAMYGSYAGSLFASIFTAVGGIMCYFLAAPFADVVTLLPSLSKPLHSMRLALHKVHQREGPTSLDGRVSHVSRGSQSGGDLWSYLLFLRLLPIVPYGMMNIACGVLGVPLLPYAITLGIGSVPWNFCTAQVGELLQDVATAIQESARVSAANSPDGLAAPSSKEASLLASGTLSVLLEHLWTWDMIIKLLLLSVASTLPIVLQRFFGSRKTHSSDDENIQIEEDSRDYEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUX3</accession>
    <name>A8PUX3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732199.1">
        <property type="nucleotide sequence ID" value="XM_001732147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUX3"/>
    <dbReference type="FunCoup" id="A8PUX3">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUX3"/>
    <dbReference type="GeneID" id="5856505"/>
    <dbReference type="KEGG" id="mgl:MGL_0792"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0792"/>
    <dbReference type="InParanoid" id="A8PUX3"/>
    <dbReference type="OMA" id="MPIRKEG"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000072">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000015">
        <property type="entry name" value="Heat shock protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="389" mass="41049" checksum="C48C02DFA98F72BB" modified="2008-01-15" version="1">MGKDYYKILGVSKSANDDDIKKAYKKAALKWHPDRNKDNEATAKKKFQDVGEAFEVLSDKNKRAIYDQYGEDGLKGGIPTPDDATGGAFPGMGGFSTGGPGGGTRTFRFTSGGNPFSGAGGFHPSDPNDIFAQIFGGASPFGMGGMGGMGGMGGMGGMGAMGAMPDDMPGGMPSFTSFGGGSSGGASRGADMGADREHKTQAKDFETPLMLTLEELYKGTTKKLKIGRTTANGRTEEKVVTIDVKPGWKKGTKVRFAGAGNEVSSGVSQDLVFVVDERSHPRFTRNGDDLRLIQPLKLIDALDPPKPGSPASRRKITTLDGRTIEVPLPSAGLGKTTISPGRTTRLAGEGMPISKVKGTKRGDLVVEWNVEFPDRLTESQRTALRNALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVG9</accession>
    <name>A8PVG9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731594.1">
        <property type="nucleotide sequence ID" value="XM_001731542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVG9"/>
    <dbReference type="STRING" id="425265.A8PVG9"/>
    <dbReference type="GeneID" id="5855900"/>
    <dbReference type="KEGG" id="mgl:MGL_0862"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0862"/>
    <dbReference type="InParanoid" id="A8PVG9"/>
    <dbReference type="OMA" id="EERIMWW"/>
    <dbReference type="OrthoDB" id="2588793at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="450" mass="50089" checksum="813B95DBEC60A471" modified="2008-01-15" version="1">MTTDASGNRPLTGGARMSPSAAKVHSIGSILTVLSSVFFAISFLCTLTGVPGGNTASLPTYNNAKVRLGSCNPFLQPGYISHSPFPLWKTFDPSCPPSTVLPDMLATLPKAKQDAATPLRSLSVSSQRQVQLMQGLRNKTVVLVGDAVDRTMIMDLCEMVGEQPVAVDSSHPWGAALKQLTFPGKNMADALLADYCYVPQYSTIFTSFYHYGADTNELWRYQQGYYPPGNFEKRVSDLLKPYLESMASRSASTNFPNLPRALSSRPDLVVFSSSLWDLAAWALQDKRDLRTNANDDLSDKRINWWRTRMVDMIEELRKQLGPSTPIAWRSTHVPMTKVNDTVEWFFTSMHARSTPAPIENGQQFAYPNRIAQLNNARNDMLQLSSATNVRGQTSKIVCSMNHQPALRNIPFGELTLGQSMNQDTLVNPGFETYAYMFWSMVLHELFSINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVI3</accession>
    <name>A8PVI3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731608.1">
        <property type="nucleotide sequence ID" value="XM_001731556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVI3"/>
    <dbReference type="GeneID" id="5855914"/>
    <dbReference type="KEGG" id="mgl:MGL_0876"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0876"/>
    <dbReference type="InParanoid" id="A8PVI3"/>
    <dbReference type="OMA" id="PHIGPLE"/>
    <dbReference type="OrthoDB" id="3346384at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="435" mass="47490" checksum="A9D81C8F8D212C32" modified="2008-01-15" version="1">MSPATYPSSTGVRRSRRLAERREASDTQMAAAASATMSVPPPAPRLDSDDIQSFDGPRPAWLTGHDTRSDTLPASPKRGDSTFEPRVLPPLSQHAMMNMPTEADTRGMGLRLPSRPRDKTIPSYAAKDIAEEGEAFPSASVASQTRGTFPSSQNSLSLGIDDWPLFEPLTTSSHSRTQPLASEGPSYSRLPSGQDSERHGSSMPTAPHIGPLESGRFSPVNMPKHHNELVHAEHEDAEIPQRHTSSHMRRSVSMQRERPLCLEGMPSETGVMGLGISFSSKDTRNNPESKSIVENMTSSLKCMSLEKKPAQAVSVLRERPSNTAPKRVPFAEKKNPVDTGAMKTKNGVSSLKAGSSTLELHASGRSVLDENGNPIAYTIPTKRYTMPVSRKPRSSTSQSAMHRDRSTFSLAYSKHGRFNTQPALHVGSRRMYALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVK7</accession>
    <name>A8PVK7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component CSL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731628.1">
        <property type="nucleotide sequence ID" value="XM_001731576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVK7"/>
    <dbReference type="FunCoup" id="A8PVK7">
        <property type="interactions" value="536"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVK7"/>
    <dbReference type="GeneID" id="5855934"/>
    <dbReference type="KEGG" id="mgl:MGL_0896"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0896"/>
    <dbReference type="InParanoid" id="A8PVK7"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05791">
        <property type="entry name" value="S1_CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="65"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="222" mass="23537" checksum="E35C1F29BA1A317A" modified="2008-01-15" version="1">MDDQQPLLLPGQPFPPLPKGEFVLGDGAYGREGYVVSDRIGHGTETKLGTQTIVKVVGTQPPLALPKAGSTVLGRVTRVNPRQATVSILVVDGLPCGGAQATRVGASNNKAAGEGIDGSDFQGIIRAQDVRSTEKDAVVLAECFRPGDIVRATVISLGDARSYYLSTAQNELGVVHATTRGPSQYGWTAAKHVLQPMSWREMADPVTGHVEPRKCAKPDWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVP3</accession>
    <name>A8PVP3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731653.1">
        <property type="nucleotide sequence ID" value="XM_001731601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVP3"/>
    <dbReference type="STRING" id="425265.A8PVP3"/>
    <dbReference type="GeneID" id="5856349"/>
    <dbReference type="KEGG" id="mgl:MGL_0921"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0921"/>
    <dbReference type="InParanoid" id="A8PVP3"/>
    <dbReference type="OMA" id="SHNWKDE"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="359" mass="39837" checksum="FC116F2663456681" modified="2008-01-15" version="1">MLSAPPPYPTVSSQNPAPDDAQIEGRPPEICVDYLSHNWKDEDVWKSWKAMTKHKNEISNGLRLENASWRTWAKQRGNLKTVSPETLNWLKESDVTWLYGPLHGEAKAVPPAKVASTAERLGIDVSTKKKSILKHRTLTEILQTPTNVSPPKKSESESPSRKSDQHQGMVRANPAPSHVRNKTLKLGSFKSNPSHQPAKKERHISFNTVVSQCIALDDDTSDMYNFDDDYSDTDDEKYDENDCKTSDSRIAQCLSSPKRAGCHATIALMPPTHLKMGHEVSSGSDPEDSIEGGLDGHATNEHDARYSVADPFLAAHDHNIVQDDGYDYYDSDEDYELEHAPSLGPDSAQNTNGSQGTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVX5</accession>
    <name>A8PVX5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MT-A70-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731710.1">
        <property type="nucleotide sequence ID" value="XM_001731658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVX5"/>
    <dbReference type="STRING" id="425265.A8PVX5"/>
    <dbReference type="GeneID" id="5856015"/>
    <dbReference type="KEGG" id="mgl:MGL_0978"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0978"/>
    <dbReference type="InParanoid" id="A8PVX5"/>
    <dbReference type="OMA" id="FWATYDT"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="50652" checksum="83A680A543D24884" modified="2008-01-15" version="1">MCERKATLQRLTHLLQVPEEGTIRNDYSANFVDSGLKTLPSAWIGNTAPETRLIEHPRLRRLTALKAALAQYAAIPRTYLQADLRAWIPTAQAIPNLGVLETLGYDVILLDPPLPSYAWNVPHDPQIYPSWSWDDIAQLPIPRLASKDSFVFLWVGDGRDDGLERGRDVLHRWGYRRCEDIVWVQTSERDAYAPQGTSLFVPVVQHCLMGIRGTVVRSTDSFFVHCNVDTDVILWPGERPEPHAPITTIRKPHELYTIIENFCLGTRRLELFGTNRNLRDGWLTVGCDVGPQAPQWPAHGAMPFEPTTYMSYFVLDPPGCPLHCRSNLLPYSEECEQLRPRTPPNRHDHSQHAPNQSDQLLSPHYHQPYQQPDLVMTHAWPSLTTMPLYTWKPRPVRLQPPLSQLLGQGAGGRATVSVPSNSERLSGAQARVLERVHETAALQRVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWB4</accession>
    <name>A8PWB4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731794.1">
        <property type="nucleotide sequence ID" value="XM_001731742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWB4"/>
    <dbReference type="STRING" id="425265.A8PWB4"/>
    <dbReference type="GeneID" id="5856099"/>
    <dbReference type="KEGG" id="mgl:MGL_1062"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1062"/>
    <dbReference type="InParanoid" id="A8PWB4"/>
    <dbReference type="OrthoDB" id="3341412at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="668" mass="73586" checksum="36FB101EDEE4870F" modified="2008-01-15" version="1">MLRCDEGIVRALFHEHGGDKLSAIDLPRVLDAYTSTHGSPLVTGDIASQITSFARENSTLIIGIDEFLGMVRSLEQETDSSIDTSNTSLLFDGKGDSPSSPDTTLDSTPSESPAKHRSPFAPRTGACVPISSSSQRMSALLPVTRSDPDVASVSARSALIRKLARVNEQLERLQTEHQMLTTEKEHRSQECSALQREVHALRRDLRLTRDHEHALEVRVHELDESVVLLQSERDSQAKILRELDARMQQQLVSFAALETQDSEHVVQLRSMQSTCHAYLADIQNLRATCDAQREAMSSLESTVDALERVHTDAERLQQQVDASRQVHEQLEQELSALRNVSAQTGPVLAEDLALYDQYSPLSSSSATDEGLESPSDCRSQNHPDSPSENQFECESACPPKSGPGHEQKVCDQVFQGQCDHLDEALANPPNAAQVSSESPSEIQPGIPGHVSGNVEPDEIQSLTRQDSLHLNDRMQNDTDQKMCRHNDDLPLAPTHSFQVITTPPRPSSPAKSYKPVSLATNVSTPCTPMPSSPSRSSTSEPDCPDTCASLTSKRSTSSLQDALLGVSSVPTTITATHSTPSPKALAPPASHHTHRPFIVSAILVHLFLLLVGMWLGLWLYDFVYRATPSLLYDRFMHQSWIEANMLYDSLDTPPSIHAWLEHYLTRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWM0</accession>
    <name>A8PWM0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TALE/M-ATYP homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731879.1">
        <property type="nucleotide sequence ID" value="XM_001731827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWM0"/>
    <dbReference type="STRING" id="425265.A8PWM0"/>
    <dbReference type="GeneID" id="5856184"/>
    <dbReference type="KEGG" id="mgl:MGL_1147"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1147"/>
    <dbReference type="InParanoid" id="A8PWM0"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="393"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="395"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="469" mass="52630" checksum="4F581C3B2E4430B9" modified="2008-01-15" version="1">MGGEQESQEGAPRLDVERLSASSSQGLPHEETGKVQFHTGANCAPAPSSSSPSNQCRLPPIDTPRPLPPHYKYPSRAPLSRLPLFKSNSLPVFTNNYNTSFGRDIGSTEADAGSAQSGLLRGNAGRYQMRNLLDSPSSFTREHETRFAPDPHRVFSPVYQDMVSRRMHPYASTERKNWDNPRCLSRTSAFNDSNMDESIECLKRRLSYQPSLYTHAWNRSFRPTDQFSADFQFRRPNLRYSRMPGRQYMSWTENSHRGYPGSFKDSIGTPFDEWHQHPFYHNGPTLLQTPQERLSANSSVSKTLSDETSTHGPKSPSATMPATFSTASRPPDNDAHGHSVSTSSDRSPVHDTEGLKYPSVIKPAPPGFSHDQHTSQFFTPKNQYQMANSSEQPVPPKRGGKLPKHITDMLKTWLLDHADHPYPTEEEKRAFCDFTGLDICQISNWFVNARRRILVPQSSRAAPAAPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWP2</accession>
    <name>A8PWP2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731901.1">
        <property type="nucleotide sequence ID" value="XM_001731849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWP2"/>
    <dbReference type="GeneID" id="5856206"/>
    <dbReference type="KEGG" id="mgl:MGL_1169"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1169"/>
    <dbReference type="InParanoid" id="A8PWP2"/>
    <dbReference type="OrthoDB" id="3355794at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725014" evidence="3">
        <location>
            <begin position="24"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="339" mass="36465" checksum="84A307F63E96A646" modified="2008-01-15" version="1">MSFVAGAVAPALLSAVMVALAHAAPASLNATLQHFNEPVPEGYAAIVPNERLNANSYTPYGRNQKVSDEGKYIFQVFPGTRVPVSSLVCVLIPFAFLLFVSASYIIARIFWSPMFSSINSTLSDREKAFQNVRLVGIRDEEKDDEKAISTPEHVSEPMTMSSQNSKDTEICKQGLSSEVPASEPARESSKSKGKDANEISGPIVPVLRNDDLLDDESIVSDAEDSEDHPEDYADELSHFNLQNQQAAADAAPSYEAANQPHPSQETPSAVVEPTANPVLTEDKVQHQPMEASPLPNDAPKPEPAIMGSACLPGDTDMQASRHGAYSGAAEQSEQNSMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWQ6</accession>
    <name>A8PWQ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731915.1">
        <property type="nucleotide sequence ID" value="XM_001731863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWQ6"/>
    <dbReference type="STRING" id="425265.A8PWQ6"/>
    <dbReference type="GeneID" id="5856220"/>
    <dbReference type="KEGG" id="mgl:MGL_1183"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1183"/>
    <dbReference type="InParanoid" id="A8PWQ6"/>
    <dbReference type="OMA" id="MLRFQRH"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="902" mass="99305" checksum="094B6AC07B1EC941" modified="2008-01-15" version="1">MDRSGTESLSSHALPVPTEQTFGMNDHSSQHYHAVEALSSNVLPSTRDRIAPPEPQAKPPSTKRRKINTCFPCKQRKVKCDRQQPYCGQCQKHRIPAERCVWSSDMTLPPDMQSAAAASAALTYTKPDASHAPMGLGAGDWAASSQGTDLALDNDTRAVIERISHLEQRLTTNTASQPTSHDLPTSSAGQTQIDPILLAGTGLSLGDVNADRSTATSLPQDAAVAAELAFWRSKMEQQHQRPPHSSDAAQMTQMQAEQNIAADALAMFARHSQQNSLPGSEQAIARPSAVSSGADTLPRHNLVHAFLDNTTFSVNSATSRVRAALDLLPDTQQTDYLLKILQTVDLHVSYGISWRLVRTQLANLRTLLASWNRMHASVPPEQLDLSFLALLLTLLGTAAQYTEARFFIEQGFCTTPEQIEPFVDSWIDCAQSLLATDDFVSKTNWNHLATLLLFVDHHAVRGRLQVSLVAMATLIRLCEQQGYHVLGSATDDERLWCQSPASRQVRVSPVSSSARPGVWLRPSAASVSLPDRSHLVREAARRLWIRIACKDMLLGTVIHRTTQVDPTFATTAPPLNVDEDDLPDGETHVLSSIQEAGRATMNNLTPYIYQIADLGRQWGLLLYSRQLTYAHVLEFDAKFRGLLSSLPVYLRPDPTLEQLPEVRQEQARHPYLAMHRLIVFEAVNQRLLVLHRDFLCRGHQDEKHAYSTRVAVDAARTILSCRQQIDNVHPAVQKHAAFRHHLFQAAIVLMLHLLAFHNKAQGSSQVAHQLRDDISLIINYLHSTGDPSTSVPIAQKVALKLIDLLFAEAHTRADRIESGISSDDKAVTESTASSTTLSTIAMDGANSSQLFPALGTAPPSTPDHVSETAASFSAQLLHPDFGNRDDISEIFASLDELMVPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWV8</accession>
    <name>A8PWV8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731966.1">
        <property type="nucleotide sequence ID" value="XM_001731914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWV8"/>
    <dbReference type="STRING" id="425265.A8PWV8"/>
    <dbReference type="GeneID" id="5856271"/>
    <dbReference type="KEGG" id="mgl:MGL_1234"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1234"/>
    <dbReference type="InParanoid" id="A8PWV8"/>
    <dbReference type="OMA" id="GEAPVWI"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="322" mass="35104" checksum="420440AF438929F9" modified="2008-01-15" version="1">MSLDLQEVLDFAISLSKQAGEAIVQGSETRFKNATGFDEKKNTADLVTETDQNTEKLVCEAIKDKYPDHKFIGEETWAAGEHPTLTNEPTWIIDPIDGTTNFVKGFPFVCISIGFVYEGDPVIGVIYAPFLGYLCAAKKGHGAFMTTPLHPERRPLPLVAPQPLPSFKQALIAFEWGSDRSAEVMEKKSRTYKRLVGDKQSGVEGGEMALGVRSMGSAALNFVHVAMGCLDAYWEIGCWAWDVCAGIVIAREAGCAVVGSKAQANNALTQSSFPPATTTPDVLTGRKYLVVRAIGDGNQESGVDAQKRIIRTYYDAVEEWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX20</accession>
    <name>A8PX20_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732028.1">
        <property type="nucleotide sequence ID" value="XM_001731976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX20"/>
    <dbReference type="STRING" id="425265.A8PX20"/>
    <dbReference type="GeneID" id="5856333"/>
    <dbReference type="KEGG" id="mgl:MGL_1296"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1296"/>
    <dbReference type="InParanoid" id="A8PX20"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="162" mass="17927" checksum="7AE4145FC8586E0B" modified="2008-01-15" version="1">MDNRIRAIREGLLRENLANQTTIMSYSAKFASSMYGPFREAVASAPSFGDRRCYQLPPGARGLARRAIVRDVQEGADIVMVKPAMPYLDMLSDARELAPDHPLACYQVSGEYAMLHAAANAKVGDLRAIVEESMTSMLRAGASLILTYFTPELLQWIDEPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX57</accession>
    <name>A8PX57_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731150.1">
        <property type="nucleotide sequence ID" value="XM_001731098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX57"/>
    <dbReference type="STRING" id="425265.A8PX57"/>
    <dbReference type="GeneID" id="5855457"/>
    <dbReference type="KEGG" id="mgl:MGL_1333"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1333"/>
    <dbReference type="InParanoid" id="A8PX57"/>
    <dbReference type="OMA" id="TEQHASI"/>
    <dbReference type="OrthoDB" id="2546621at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32447" checksum="F014C979AF5ADC04" modified="2008-01-15" version="1">MDWDAASIATPPPRYDLESDEEEIAPDNEVVFHPNLQLLGDMPALLERSLVVLLGNVGTAVMLASKRIFPEVACIDVDSHGRIASVHAPFDTQMPCVLSVPQAETIPVVIQSLIAKLVMEKMRPVSMVIMQGYTEALYCNSMGLSETDSSFQPLRYLSNVPMNASPTRPSSDVAPWETPNSLSGCGAAFFMHAVYRHTPVQIFCVPSAQVAPHPNYQRRLMHFVAPHGHQSLSSDEARRRLNTLIPPLEEHHLKTLGPMLGKGSEACDGSSSLLVHALLATLATRPSVESLGEGGMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX59</accession>
    <name>A8PX59_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731152.1">
        <property type="nucleotide sequence ID" value="XM_001731100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX59"/>
    <dbReference type="FunCoup" id="A8PX59">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX59"/>
    <dbReference type="GeneID" id="5855459"/>
    <dbReference type="KEGG" id="mgl:MGL_1335"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1335"/>
    <dbReference type="InParanoid" id="A8PX59"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="670"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="696" mass="79075" checksum="22EBE3225A604F9F" modified="2008-01-15" version="1">MADKQETFGFAADISQLLDLIINTFYSNKEIFLRELISNASDALDKVRYQALTDPSVLDNEKDLYIRITPDKENKVLSIRDTGIGMTKADLVNNIGTIAKSGTKAFMEALSSGADISMIGQFGVGFYSAYLVAERVQIITKNNDDEQYVWESAAGGTFTITPDTSGRSIGRGTELRLFMKDDQLEYLEEKRIKEIVKKHSEFISYPIQLVVTKEVEKEVDEPEAETADEEKKPKIEEVDDESADKKKKKVKETVKENEELNTTKPIWTREPKSISNEEYASFYKSLTNDWEDHLAVKHFSVEGQLEFKALLYVPKRAPFDMFESKKKRNNIKLYVRRVFITDDCEELIPEYLNFVKGVVDSEDLPLNISRETLQQNKILKVIRKNVVKKTLEMISELAEDKENFAKFYEAFGKNIKLGIHEDATNRAKLAEFLRFHSTKSGDEMTSLADYITRMPEIQKNIYFLTGESLAAVKDSPFLEVLKKKGFEVLLMVDPIDEYAVTQLKEFEGKKLVSVSKEGLELEESDEEKKQREEEAKKFEELTKSIKDILGEKVEKVTVSNRIVGSPCVLVTGQFGWSANMERIMKAQALRDTSMSQYMASKKTMEINPHNAIIKELAAKVANDKNDPTVRDLTMLLYESSLLTSGFSLEQPQDFANRLFKLISLGLSIDDADTQPETVEESKSDEPAGESAMESID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX87</accession>
    <name>A8PX87_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731180.1">
        <property type="nucleotide sequence ID" value="XM_001731128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX87"/>
    <dbReference type="FunCoup" id="A8PX87">
        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX87"/>
    <dbReference type="GeneID" id="5855487"/>
    <dbReference type="KEGG" id="mgl:MGL_1363"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1363"/>
    <dbReference type="InParanoid" id="A8PX87"/>
    <dbReference type="OMA" id="GDWESCK"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="318" mass="34966" checksum="B1EAB42B6EB4F56D" modified="2008-01-15" version="1">MPDFSIIESFHHALEEDKDRPMPIAAIFALSDMILQSRAGTTSELMESIKMASEELKASLPNPIPATAGLELYMRFVTTKNWAGGDFEAHKRSLIHTALEFAQNTVPNCRERITHLLLPFVKDDSVILTHGYSRVVMQALLTAVKTHRKRICVYVTESRPTGQGLQTYHRLREESIPCTVVLDTAVAYLMHRVDMCLLGAEAVAESGGIFNAVGSYQIGIIAKAAKKPVFAVAESFKFMRLFPLSQYDVPISARRLPLPSPNDPCDESQGNRMTPAMEALNPLIDYTLPELLTFIVSDVGILTPSGVSDALLAVYGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXS4</accession>
    <name>A8PXS4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731331.1">
        <property type="nucleotide sequence ID" value="XM_001731279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXS4"/>
    <dbReference type="GeneID" id="5855638"/>
    <dbReference type="KEGG" id="mgl:MGL_1514"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1514"/>
    <dbReference type="InParanoid" id="A8PXS4"/>
    <dbReference type="OMA" id="DHICIAR"/>
    <dbReference type="OrthoDB" id="3359711at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="339" mass="37537" checksum="8700EC280AAAFF6E" modified="2008-01-15" version="1">MRVSDGPGAQSHTRRTNTPLTKMSCWPQEPVPLSPTCAGYEGTMRLDEKAYPCPKQTKSLHGGSNEGDETSFSPNSFLLHTHSPAQVATSPLMGSPMERSYSLPVATQKEFDDHICIARQSGHECQGASRSQDYHFRTRACSCQARLLGMDENDKCLDTAIQIQCCWAQPWPGSYCSTTSFETDLDQPCGDPSVKDIEDVDIDIEEELLDQKSSAQTRKHLSWIPPAGSDRVSLGRVCTTPPPMLSKHYQDLGEWPSHRSKYVHPSVNESRLLDHHLHVSTSQDGLYPSSKAASSHARTLFEATQKAYIPRIVSGLSGSRPVPVSTKCQSFFIHPKHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXZ7</accession>
    <name>A8PXZ7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731377.1">
        <property type="nucleotide sequence ID" value="XM_001731325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXZ7"/>
    <dbReference type="FunCoup" id="A8PXZ7">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXZ7"/>
    <dbReference type="GeneID" id="5855684"/>
    <dbReference type="KEGG" id="mgl:MGL_1560"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1560"/>
    <dbReference type="InParanoid" id="A8PXZ7"/>
    <dbReference type="OMA" id="QQFYHTI"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="100"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="629"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="866" mass="96622" checksum="F6250EB48352A8FA" modified="2008-01-15" version="1">MAAVATTGPKAASVRSVTSEPHTPASQDDVAAQVDALLLDSVQSSTSAKSQLTDPSDQASTPTGPGTLFQELSIPHVQRAQSEIHAKLALNRQNTHALLATASHSVPDAHDQNAQELLTSLAHLEKHASRAEASVGEITAEIRWLDMAKRNVGLSIVTLRRLQMLVSSTMHLEQLCELKQYREAASALQAVQALLSYFEQFRAVPCIVQLQTHIQVLRDKLHRMVMDEYESVFQTAKHRLPARESVLPDAALVVDALGPDVCEKLIDWYCTRQLREYRRVFRAVDEAGQLDNVPRRYAWIRRLLRIYADEHAPAFLPQWNVDHRLLTLFANITHDDMRSVLVREQPRLQVDVLLHALHVTNEFESQVARQYGITFSQSRPISSAFSPYLGIYVDAQDRKLADMLAQFAASATTAAEPNIGDEPVRVLVSSTDLVTFYRQTLERCAQLGPRAPLRELANVYSKWLKKYAADVLLPALHTKDALHLCTVLNTADYCATTCTQLAERLTEKQRALDKAAPAVVLESERDVFFGVITSALQSLVRTLHTALDPAFQALLRPEIPWAQRDQVDDKSAWVDLLASGLESIGVIVRHHVENKRYVRSWCDKAAALTVTRIVQSIVRLRPIRRRMAEQLERDVHHVHTLLLEWPHFAAASSTGSRATPQPQSLQTAYSRIVDKAMARIEPVLSMLIAPDDPRAFVEAYRQRVGDQSLGNFQKLLDLKVRIHALASQSACDMLGMSVYVMRYRHARHHCAAVRQRPRSVLTRMSQGLRRLDQNPLVEEFLAAIDRAPDALPTTSALSTLQLDPNADVYAMPELGDRTKDDLPDASLVHRPTTPSSSSSTAAAALSLPDWKKFGSMFGVALGQRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY85</accession>
    <name>A8PY85_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase 1</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1612</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731429.1">
        <property type="nucleotide sequence ID" value="XM_001731377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY85"/>
    <dbReference type="FunCoup" id="A8PY85">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY85"/>
    <dbReference type="GeneID" id="5855736"/>
    <dbReference type="KEGG" id="mgl:MGL_1612"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1612"/>
    <dbReference type="InParanoid" id="A8PY85"/>
    <dbReference type="OMA" id="HRWKEVK"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="12">
        <location>
            <begin position="272"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="652"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="787"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="656"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="877" mass="100456" checksum="DBA88DBC41E9F085" modified="2008-01-15" version="1">MADAERERDDLKRDPVKQEDDSDEDMPLSVVQSQASDSDSDVPISQQTSVRGDIHEEHDGDEDHDEGDEEDDSDDEEDEAEEEDDDEEGDAPLAGKKRKRSNRKSSSQRSKSDIEGGGEQRWTTLIHKGPKFPEPYTPLPKDVMLKYDGHPVPLPPESEEVAMFYAVKLESQHASNPIFNRNFFEDFCGYLKQYPPKDGTKIQKFEKLDFRDMYNYWMSLKVAEAERKKSMAPSMRKAELAARRAIDNEYKLCLVDGIEQKAGNVTVEPPGLFLGRGAHPKAGRVKTRIQPEQITINHSADHPPPKPPKGHSWGEVVERKDVTWLALWRENINGGFKYVFLDASSTFKTESDREKFEKARRLDTCVKQVRADVLKNLRSKDRLDQMIATIVWLIDNFSLRAGNEKGEDEAETYGVCSLRCGHATLIPPNQLNLSFLGKDSMKFEETLTITNPHVYKNITSFLKSDGHQKKGPDDPIFAAPKARGDKMTPLPPDVVNQFLGRYMKGLSAKVFRTYNASATFQGLLDETEEWLASRPTPQEREITPANLRIAYNEANRQVAILCNHQKTVNHVTLNKSLDRTKDKIFAIKYDIYKEQQKLLTFNNASELKKEYLPKDHDFAKSWNLILKRLDLDVSRIEEHEEHLIEAKKSRMTTAFERQESERRFQEEQRKAERSSKVKKEEKDNEEVKTSKGITTKAELQAELKKLDAHLKILQRERKTNKSEANSCNVPSTARRILSKYEAIKKQEAELLNKNNTSDVSLGTSKMNYIDPRITVAWLKKWDAKLQTMTPKKPAKASESNKKSSKTKTEEPPPDPATSEKMELNLQVMNIGQFFPMTLQKKFKWASFDEKGKPLPSNWSFVKDARKKMRTLGSAERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYE8</accession>
    <name>A8PYE8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731465.1">
        <property type="nucleotide sequence ID" value="XM_001731413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYE8"/>
    <dbReference type="FunCoup" id="A8PYE8">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYE8"/>
    <dbReference type="GeneID" id="5855772"/>
    <dbReference type="KEGG" id="mgl:MGL_1648"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1648"/>
    <dbReference type="InParanoid" id="A8PYE8"/>
    <dbReference type="OMA" id="KVYYMFG"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007360292" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="21"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="633" mass="70461" checksum="F656908680B8D207" modified="2008-01-15" version="1">MRLLLCACACALSLAWGVNAWYLPGSAPRSYANGQSVPVHVNALQPMAGATPVHGLVSYDYYDERLGFCRPSSGIKAERGSLGSILFGDRIYNSPLAVDMLQAKSCVPICKTQATPEQADFINKRIFERYAVNWMVDGLPAADIDLATNAEQSLRANSVGFVLGTILDAQGHRLKTPALYNHYQLNISYHERSPNEYRVVGVNVRPMSLSSLPAGNAGAEPRCDVNEPMFLNPNATTPVVYTYSVVWTRSNTPWATRWDAYLHVVDPRIHWYSLLNSTAIVALLCVIVTIIMARSMRRDIYRYNAIDLAEDIQEDFGWKLVHGEVFRPPASSMMLSVMAGSGAQLGAMASVTLLFALLGFLNPSNRGSLGTIMIVTYTLFGCLGGYVSARVYASFDGALWRRNMFLSAVLLPTAVFALMNLLNFVLVLNHSSGAVPFGTLLALVALWFLIHVPLSLIGSYFGLKAGGFEHPLRVNQIPRQIPPAPWYLRLWPSAMLSGLLPFGAAWLELFFIINSLFGNRVYYAFGFLSLTFVVTVLTTATVSILNLYCHLCAEDYRWQWRSFITGGASAFWLFMYGLFFCITRLNLPDLSSKFLFIGYLLMISTLDFLLFGFVGFITCYICVQRMYRHIRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYT0</accession>
    <name>A8PYT0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731536.1">
        <property type="nucleotide sequence ID" value="XM_001731484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYT0"/>
    <dbReference type="FunCoup" id="A8PYT0">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYT0"/>
    <dbReference type="GeneID" id="5855843"/>
    <dbReference type="KEGG" id="mgl:MGL_1719"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1719"/>
    <dbReference type="InParanoid" id="A8PYT0"/>
    <dbReference type="OMA" id="FGVMSLY"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="252" mass="28590" checksum="528568674A8E8C19" modified="2008-01-15" version="1">MSKADTPPPYRYQAIETNETVDHGEVNPDDFKIGVTVEQSAPEIRAMFVRKVYSVLFFQVLGSCIVASGMYATSVTSWVMKNPWFMLLTLIGSFGSLGLVYWKRHNHPTNLYMLGLFTSVESVALGTLVSFLDQTIVLKAIIVTAFIFLGLTLFTLQSKYDFSHMGTWLYWSLLILVGTGLVQMFFPYNHLFELAYSIVGCFVFSGYVIYDTWLLQRRLSPDDWVLANVSLYLDIVNLFISVLRLMNGSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZZ3</accession>
    <name>A8PZZ3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730965.1">
        <property type="nucleotide sequence ID" value="XM_001730913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZZ3"/>
    <dbReference type="STRING" id="425265.A8PZZ3"/>
    <dbReference type="GeneID" id="5855272"/>
    <dbReference type="KEGG" id="mgl:MGL_1964"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1964"/>
    <dbReference type="InParanoid" id="A8PZZ3"/>
    <dbReference type="OMA" id="IKFSRQN"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="235" mass="26332" checksum="15A0196C9D48FA3E" modified="2008-01-15" version="1">MALPPSLQALSIGARDATNTLEFYLDYLCPFSAKILLNFHEQIVPLVCGENARYRGQLRVVIRPVPQPWHASSTLLHETALAIARLAHDNREMLENAYTNAFWHFSIALMRSAESWFDENARSKTPDQMRAELVSLAVTILGDDARKAGNKPLVHLPDGETLTNAVHSWTRVGKGNDGSRIVPDLKYCVKIGRQNGIHVTPTALWNGVVEPSISSSFSKEQWMNFLDERIPRANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0S3</accession>
    <name>A8Q0S3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Upf1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_2074</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731075.1">
        <property type="nucleotide sequence ID" value="XM_001731023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0S3"/>
    <dbReference type="FunCoup" id="A8Q0S3">
        <property type="interactions" value="833"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0S3"/>
    <dbReference type="GeneID" id="5855382"/>
    <dbReference type="KEGG" id="mgl:MGL_2074"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2074"/>
    <dbReference type="InParanoid" id="A8Q0S3"/>
    <dbReference type="OMA" id="QYMQMNG"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="17">
        <location>
            <begin position="91"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="15">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="15">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="15">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP43861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1019" mass="114727" checksum="6C452A6F3409A974" modified="2008-01-15" version="1">MARGSSKSGHPSVQKLTEDVRNLQIQNEPDVGNTEKGNMKGKKNKPKNKTKAKVEHKDDENNLVHPQEQEPLYEYDQEEREEDKEAPTEPEEILPEHACAYCGLADVDCVIKCTVCNKWFCNGSGKTTSSHIVTHLVRARHKAVMLHPMSPLGDTVPECYTCGSKNPFVLGFLPAKGEAVVMLLCRTPCNFAANTKDMDWDASQWSPLIENRAFLSWFVKIPSLKQQKSARQITSDQIRKLEDLWRENELATLRDVENPEQERKLPETMIKYDSLAQYYEIFRVLLSVEEAYDKKIKENLAQHDITVRWEETKNMLLVWLRLPQLESGEIRLSMGDELLLRYTGSMAPAWESTVTVVRFSPTSSMEVACEVPKHLSPPLECTTNYMLEFVWIGITYSRMKNALSRFSRGRPCMSTYLQKVLLGIPSKAIPLQVQMPRRLHVSGLPELNYSQLTALKTVLTSPLSLIQGPPGTGKTVTSASLIYHLVQMKRGKILVCAPSNVAVDQLTEKLHRTGLKVVRLVSRMRETISSQVRFLALHEQVAQVEENTELSHLIEQKRNNGELSTMEERRYRSQVFQREREILDAADVICTTCSSSADRRLHSYEFQTVLIDEATQAVEPECLIPIVRGCRQLVLVGDHKQLGPVVLNRKVADAGMNLSLFERLVLLGVKPRRLEVQYRMHPALSEFPSNMFYDGMLQNGVSAHERLRRNVAIPWPVPNMPMMFYQNLGQEEISASGTSYLNRTEASSVEKLVTTLLKAGVAAEHIGVVTPYEGQRNFVINYMQLHGSMMKDAYRNVEVASVDAFQGREKDYIIVSCVRSNSSLGIGFLSDPRRLNVALTRARFGLILIGNPRILCKNPLWYHLLVHFKDRNLLVEGALSNLQPSMVRFGPPPVERRVMSRFERAASEANSVNDSLAMDPVRAPFRGSMASVDLLREGMWGTLSLDARSLSMTQSDLITQSLKQKETDLDSLDGFRSQASVADSLEDETNEDPMATMGIDSAAPGSGGLPAKPSVTQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1P0</accession>
    <name>A8Q1P0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730818.1">
        <property type="nucleotide sequence ID" value="XM_001730766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1P0"/>
    <dbReference type="FunCoup" id="A8Q1P0">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1P0"/>
    <dbReference type="GeneID" id="5855125"/>
    <dbReference type="KEGG" id="mgl:MGL_1817"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1817"/>
    <dbReference type="InParanoid" id="A8Q1P0"/>
    <dbReference type="OMA" id="IDGPFKY"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="58"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="230" mass="25658" checksum="26E959A5DC7231AA" modified="2008-01-15" version="1">MTAVPAYLQSKHTTKKPQHPWRPHRRSFFNVGSFLGQGPLGGGGSTPSTKRYQETVILPYTQQELYAIVSDVDSYSQFLPYCQKSRVLGPSRSVRAQANQENANKIVDAELTIGFSAVHESYISEVSMRPYEWVRAQAKPSPLFHELHTTWQFKALPPLSPSTTTQSTGQLGAQVTSSTPRTQVSFTLAFAFSSQLYAALVGQVFESLSSRMIEAFRARAHTVYGPRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q274</accession>
    <name>A8Q274_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_2159</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730705.1">
        <property type="nucleotide sequence ID" value="XM_001730653.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q274">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q274"/>
    <dbReference type="GeneID" id="5855011"/>
    <dbReference type="KEGG" id="mgl:MGL_2159"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2159"/>
    <dbReference type="InParanoid" id="A8Q274"/>
    <dbReference type="OMA" id="NRGYHMY"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21323">
        <property type="entry name" value="KDM5_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="17">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="16">
        <location>
            <begin position="103"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="220"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="18">
        <location>
            <begin position="360"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="1333"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="726"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1269"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1474"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1641"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="758"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1273"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1481"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1689"/>
            <end position="1700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP43491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1700" mass="188231" checksum="54315D6E76F32AF7" modified="2008-01-15" version="1">MADKHMPPPIPTGATTPRHMPARTKPRLFELEDAPVFYPTWDEFQDPLKYIEWTARADGGNGAEYGIAKIVPPSGWHMDFCVDESTFRFRTRVQRLNELSAEGRVAQNYVEQLEQFHAQQGHGRVHIPQLSHRPIDLYALKRAVAVCGSDSWTDVAQRLGYDVENTPKCVSALQSAYARLVEPFEAFIEKLRLSKANGDDAKSQGPLPTVTNTQERTTACSDCSVCKGHAKPIVTCAECEQSYHLKCVTPPLSQVPRGDWICPTCLVRTGGDFGFDDGETHSLYSFWRRCHAFEQLWASRAGWTDWDSISLSEREDRVEAEFWRLVHSAEELVDVEYGADVHSTTHGHASPTMEGHPRNAYARSGWNLNNLPILHGSLLRYIRSEISGMTAPWIYIGMMFSAFCWHNEDHYTYSINYQHFGATKTWYGVPGAHAEAFESAMERIAPELFAACPDLLLQLVTMMSPELAKREGVRMYACNQHPNEFVVTYPKAYHSGLNHGFNLNEAVNFALPDWVMQGLECVRRYQKHARQPVFSHDELLVSIALHSQQLSTAAWLHPAFDDMVSRELAGRARIRSSICAAGPDVDEEPFDQDVEVACAHCKTLCYLSHVVSLHSAASKAACLAHAEQVHGRHPATWMLRVRHSDDFLRTHASRLAERAAAPLAWQQRVRRFLVQHPRPPLRTLRMLTQEGEKIPLRLPEHACLEQFLSRAEPWIEQARVFLSKRQAKQGGRRAKAVEPKRGESTLRRSGSAAGPGISSTSTDSSCASSESTVAVDRSPAKLLALHERAVSLPFDAPELQQLNAVVDQMHAFCAQASTYLDRDAETRDALSYVDEAERVLAQGELLHVDLPEVAALHRWIAHVRWFSEVQDIGSGFLTRDEVAELEKEANACGISASHPMRLTLEQRMQRGMAWDSAALALLEQSPVVSQAALHDLLNVPADVATSSDIRARVHALEHKAAQWHSTITTVYEHTHPSAQLRTSDVPDHVPYLSEARQVLADAHAARVELPHAASIEAAIVLHDEWNAELAHILQLSGPDAIEAVREFCERTIRTANAEAVNRGACDAPTCAPILSYPPVPYPAPRSVEAPCLCFEARTDRTTSVACAQCCTVYHLRCLDRKTKPSRGWRCAFCDVTQLRTWLTNRRAISQLPLVALLQNAKYQRDQLRFVPVNFVRLQAAVRATVEFGVAVAMQFQAGRLPSILIDAPAKTGQAIDLPPPSPQLRHIARRALACPIDVLLLGDSAPQHHQHVPNVLDVFLPAFHITPRMHSGSTSLKGKRSASSSSMSLSQTKEVAATAQPRAPARAPPPRKRAKRARFTFREELRLASLPPDMYCFCGAPDNGTMVQCDRCSHWFHSACMCIQDTTALQDKWFCPVCCFRQRIKYAHADVKIRDVTGETDPAAPSQPDYFVDVAGSLKSQSTPVLKRQACVAPRRIILHLCEFEPAIPAAELSHSAGDSSAVAAAARPAHFRPSIHDESGASTSASAPVTDSTTSHIPASLSHAPPAKRARLEPLARPPPSQRPTISLPVSEEERHRLGRANLLRRGVSEAMMNAYPMGWDGESIVCQIAPDCHVLLGPHISLAHDDPDGTHLLRMAMEGLVPWASYIRSPSMWHPGPPSTTMPPPRLPSITAMRPDATSQTFPTMAPPMSSGQHIPPHVPHASSMPPLDRSSITQTPIAPPAPPALPAHSMAPHTYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q285</accession>
    <name>A8Q285_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA repair protein RAD16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2166</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730712.1">
        <property type="nucleotide sequence ID" value="XM_001730660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q285"/>
    <dbReference type="FunCoup" id="A8Q285">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q285"/>
    <dbReference type="GeneID" id="5855018"/>
    <dbReference type="KEGG" id="mgl:MGL_2166"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2166"/>
    <dbReference type="InParanoid" id="A8Q285"/>
    <dbReference type="OMA" id="DHIMLRR"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="235"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="571"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="670"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="95854" checksum="CF4642E37D682354" modified="2008-01-15" version="1">MRPYRTRAAKAPRIVYKDYSDDDDEKDAASASSEEDESDFKDSGASSSSSLSDVDRHERAIFAIKDSDLGDKQDANFFTDPKRMGVKQEDVPALGLLSSDHDDCPKRRSKMIQDSQSSHLRTDDSTRMLDQCSHNVPAKRAQAASDTDSDTPLAQLVCHKKQEKPKLTRFQRSLAQLNRMHPELIAVWDTLQTLRRDKTKQAPRAEQPEGVSISLLPFQLEGLYWLQHQEEGVWRGGLLADEMGMGKTIQMISLLVADPKRPSLVVAPTVAILQWRNEMQKYAPGLRVVVWHGAQRSRDRDTLSTVDVVLTSYAVLESTFRRDRYGVTRNGRHVREQSLLHAMKWRRIILDEAHHIKERTSNTARSAFALQSDFKWCLSGTPLQNRVGELYTMVRFLGGDPFAFYYCRQCSCKSASWEFHNNSYCVHCGHKPMVHLSFWNFMILRPIQRDGTEEGEGEEAFARLRLLLDCIMLRRTKLERADDMGLPPRTIEVRRDYFSPEEEDLYRSLYSSTTRKFSTFLDQGTVLNNYSNIFTLLTRMRQMSNHPDLVLRSATRSNVDLLGDVDQVNVCKLCLEEAEDAILSQCRHVFCRACMQQYLNSFEGDQDPSFRRDTQDEPDCPYCHAVLSVDLDAPALEPPQPLAVHGDPKRQGILSRLDLANWHSSTKIEALVEELTHLREQPDRTIKSLVFSQFVNFLDLIAFRLQRAGFRICRLEGNMTPDARDRTIRLFMENPGITVFLVSLKAGGVALNLTEASRVYLMDPWWNPAVEVQAMDRIHRLGQHRPIVVKRMIIENSIESRIIELQNKKSAMVDAALGNDDSAMGRLSVDDLRFLFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2M5</accession>
    <name>A8Q2M5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730414.1">
        <property type="nucleotide sequence ID" value="XM_001730362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2M5"/>
    <dbReference type="FunCoup" id="A8Q2M5">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2M5"/>
    <dbReference type="GeneID" id="5854721"/>
    <dbReference type="KEGG" id="mgl:MGL_2210"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2210"/>
    <dbReference type="InParanoid" id="A8Q2M5"/>
    <dbReference type="OMA" id="WYANCPG"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="51"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="378" mass="40892" checksum="C16DEAA473B0D93A" modified="2008-01-15" version="1">MLAASLRAHCARPNVFRSATVPRIVVSSPVRMPAIRLPLRMYASDSGAQEMAVRDALNSAMEEEMHRDPKVFLMGEEVARYNGAYKVTKGLLDKFGEDRVIDTPITEQGFAGLAVGAAFAGLRPICEFMTFNFAMQAIDQIINSAGKTHYMSAGLVAAPVVFRGPNGAAAGVAAQHSQDYTAWYGQVPGLKVVSPYSSEDARGLLKAAIRDPNPVVVLENEILYGHSFPVSQEALSEDFVIPIGKAKIERSGKDVTIVSHSIGVDHGLRAADMLAKEGIEAEVINLRSIRPLDIESVIESVKKTNRLVTVEGGFPAFGLGSEICAQIMESEAFDYLDAPVERVTGADIPTPYAENLETLSFPTPEIVARVARRALYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2Q6</accession>
    <name>A8Q2Q6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_2220</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730424.1">
        <property type="nucleotide sequence ID" value="XM_001730372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2Q6"/>
    <dbReference type="FunCoup" id="A8Q2Q6">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2Q6"/>
    <dbReference type="GeneID" id="5854731"/>
    <dbReference type="KEGG" id="mgl:MGL_2220"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2220"/>
    <dbReference type="InParanoid" id="A8Q2Q6"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="96"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP43210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="549" mass="61963" checksum="C6533C1EB61311FB" modified="2008-01-15" version="1">MAVSSTSTSAECLLRVCADIAAQLVHAHEESKSVSLNAIRSASCKKHGYGGVPRLTDIIAAIPDTHKKILVPALRAKPIRSASGIAVVAVMCKPHRCPHIALTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYEQSRGRVQQLRELGHSVDKVEYIIMGGTFMSLSEQYRNEFIAQLHNALSGYTGLDVDEAVRYSERSQTKCIGITIETRPDYCLRPHLSQMLRYGCTRLEIGVQSVYEDVARDTNRGHTVKAVCETFHLAKDAGYKVVAHMMPDLPNVGVERDMEQFKEYFENPAFRSDGLKLYPTLVIRGTGLYELWRTGRYKNYTPSFLVDIIARILALVPPWTRVYRVQRDIPMPLVSSGVENGNLREMALERMRDFGVTCRDVRYREVGIHEIHTKVRPEEIEFLRRDYTANGGWETFLSYEDPDRDILVALLRLRKCSSTGTYRTELLKDGQTSIVRELHTYGSAVPLHSRDPTKFQHQGFGTLLMEQAEAIARDEHGSVKMAVISGVGTRDYYRRLGYELEGPCTYNACLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2R4</accession>
    <name>A8Q2R4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730428.1">
        <property type="nucleotide sequence ID" value="XM_001730376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2R4"/>
    <dbReference type="FunCoup" id="A8Q2R4">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2R4"/>
    <dbReference type="GeneID" id="5854735"/>
    <dbReference type="KEGG" id="mgl:MGL_2224"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2224"/>
    <dbReference type="InParanoid" id="A8Q2R4"/>
    <dbReference type="OMA" id="EFKWHII"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="388" mass="43470" checksum="37CD140EFA0658A7" modified="2008-01-15" version="1">MPWSQDVKATWLEEVIFLGTGTSSQVPAIHCITDKNSDCVTCTDAMKPGSKNRRFCTSAIVRGSKQGCPGTSSTILIDCGKSFYESALRYFPVYGLRNIDALLLTHAHADAMLGLDDLRSWTMNACIQTHVDVYLTRECMDTVQQTFPYLVDTSRATGGGDVGALRWHIIDPHTPFLAGPQQVPVQPLYVEHGYTHGGRVPFACLGFRIDSMSYISDCVRTSGCTHLCRRRSNSQHHIPETTMEKVVGSDLFILDGLKMNRHTSHFSIPQAITCTLDLCMRHAHRQLSPPSLTVLTDITHRLEHHSTESQIVTLLDGLAAWLHQQGWSATDAPSRWWTRIWDEQENELHERLQLTPLSSSLSIKHAHPLVPDMRVAYDGARVTFSRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2U5</accession>
    <name>A8Q2U5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730441.1">
        <property type="nucleotide sequence ID" value="XM_001730389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2U5"/>
    <dbReference type="GeneID" id="5854748"/>
    <dbReference type="KEGG" id="mgl:MGL_2237"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2237"/>
    <dbReference type="InParanoid" id="A8Q2U5"/>
    <dbReference type="OMA" id="VNERAGW"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="40033" checksum="E370994323EC8494" modified="2008-01-15" version="1">MGATAFSNVAGSIVDMTTERERNPYNTMFRFFTFMGPAVAATVGAVVVHDSNWHWNLRSLPVAAFACLVLYTWTVPETYLPILIEQQIETEMENVEEQLHHHSWFHRKVNHIYHHLPGLKLVKLLLWRVIVSLPVPWILLIEEPLIMVITFYTSLLYGLLYGFLLIFPQVWGTVRGFSPVQVGYTYFAVMAGFCLSTAFVSLWIQNTEYRRAYDMNKHSPELRIRSGLFSTFLVPIGLFLFGWTAPFPHVHWIVPCIGAMCFSMGMLCVFSSWMAYMTDTYSNNTAAVIAMNSFVRCGLAGAFPLFTEQMVTGMTLQGAMTLFGGISIPLSGAGLVIAFYGNRIREKSRHAVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2Y4</accession>
    <name>A8Q2Y4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_2269</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 13"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730473.1">
        <property type="nucleotide sequence ID" value="XM_001730421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2Y4"/>
    <dbReference type="FunCoup" id="A8Q2Y4">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2Y4"/>
    <dbReference type="GeneID" id="5854780"/>
    <dbReference type="KEGG" id="mgl:MGL_2269"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2269"/>
    <dbReference type="InParanoid" id="A8Q2Y4"/>
    <dbReference type="OMA" id="KSETEHY"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="15">
        <location>
            <begin position="97"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP43259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="253" mass="28776" checksum="80CFB648F8A92771" modified="2008-01-15" version="1">MFSSPYSPQTHIVPVIHTWRDMYERITAENPFVKYIQFFENKGQAMGCSNPHPHGQVWALDYVPCEPATEMQNMNEFAANPNHSDAPGPRDALGRPNLLLAYAHMELTTSGRPRVVSVNEDFVALVPFWATWPFEILLLPHRRFIPSIQDLSHSEIHTFATILGEITCRYDNLFQTSFPYSMGLHQRPVLSASDQESESALLHIHFYPPLLRSATVRKFLVGFEMMAEPQRDITAERAAALLCACSTTHYLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q394</accession>
    <name>A8Q394_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cwf19-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730544.1">
        <property type="nucleotide sequence ID" value="XM_001730492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q394"/>
    <dbReference type="FunCoup" id="A8Q394">
        <property type="interactions" value="816"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q394"/>
    <dbReference type="GeneID" id="5854851"/>
    <dbReference type="KEGG" id="mgl:MGL_2340"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2340"/>
    <dbReference type="InParanoid" id="A8Q394"/>
    <dbReference type="OMA" id="GHYIRAC"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="2">
        <location>
            <begin position="409"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="588" mass="65029" checksum="3F056BEA451FCFDA" modified="2008-01-15" version="1">MSEQEKVLLLGPPNGRVRAMVEKTQAIEARHGPFSLALIVGNVFADAEHLTEDETAFLHGSLTKNVKSYLNARGASRRGPVEVASNLFYMGSAGIATIKGLRVAFCGGVWTKPSLSTNAPERADVCAWREPTGTTDDMPFEWSTWDTLETRAASEEALRHLLRHPAVALGEARAPELPRDPESLKQVRAWQYAQAAFEFQQEQDAPALRRRAPIDFLLTNAWPLGIEAFSCLPPQQQENTNNATAVEQGLAPLARLAEACRPRYHIACARDAEPDGLYWEREPYENWPFAKVPEPRSRRVTRFVSLAAAANPRKCRWFLALQVVPSGALYQDPGRPFPRSELDDAVPPTTTPMPLWQMVENLSARAATRLGAASDVPHNGDTPRKKRTRTEARSSVHKRRAGATLQPVEPDTCWFCLSNPAVEKHLIVSIGAECYIALPKGQLPVSSSDETLVPGGGHVLIVPIVHTPSLYARETSNADLRREVSAWKHALRACYDAYEAVPVCWEVVRRASRVAHAHVQVLPIPKAREAECVQYVREAAERDGLTWESDAVARAWADVDNVCTRDTCDFLGHVGAFRLARMCALARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3A9</accession>
    <name>A8Q3A9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">MGL_2350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730554.1">
        <property type="nucleotide sequence ID" value="XM_001730502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3A9"/>
    <dbReference type="FunCoup" id="A8Q3A9">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3A9"/>
    <dbReference type="GeneID" id="5854861"/>
    <dbReference type="KEGG" id="mgl:MGL_2350"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2350"/>
    <dbReference type="InParanoid" id="A8Q3A9"/>
    <dbReference type="OMA" id="LQEPCSI"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="348" mass="38376" checksum="148F74DCD4E9409A" modified="2008-01-15" version="1">MLPDMDALEASLLNTSGTVKLDVRFRTLFTLKGLAALSEEKRRRVIEIISKGFEDDSALLKHEMAYVLGQIKDTDALPCLESILSNMKEHCMVRHEAAEAMGAISSPSALPVLKKYLHDDDVSIRETCHLAINKIELDNSEAGRNEQALKDLREKEHGDAVSAARAAAAPIDPAPATVNVPGTQHAHQNVYTLENVPKFRETLLNRSLTLFERYRAMFALRNTVQQGGREAQVPAVKALADGLEDDSALFKHEICFVFGELCHPASLQPMSRVLNDAGEHEMVRHEAAEALGAILEEGAGDSEADQIIKVLRQYAEDASAPRVVRESCIVALDEIAYNQDPSQFQRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3J1</accession>
    <name>A8Q3J1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730623.1">
        <property type="nucleotide sequence ID" value="XM_001730571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3J1"/>
    <dbReference type="STRING" id="425265.A8Q3J1"/>
    <dbReference type="GeneID" id="5854930"/>
    <dbReference type="KEGG" id="mgl:MGL_2419"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2419"/>
    <dbReference type="InParanoid" id="A8Q3J1"/>
    <dbReference type="OMA" id="PAGWRNG"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38480" checksum="5F6A6FED1030B4A8" modified="2008-01-15" version="1">MGHTQNMEHKIYKRTFGEWCDSIWIHRSFVGELLIPLFCSIMTANVDAVRSMPAAEVLDYVARTFLYDHYTVQGGVSQVVDGLSFYLSPSQKRVGVTITDVFPQHVNDKRQFGLRFTTADGEQMEATFDHIVFASQATQTARMLEMYYHHLSRSSGNFLSSPHSQRCRQQLESLRRMRYEKSTVVCHTDTTILPPKQEHWRDLNLVSPLNPHSPDASFTMATHIIWRTSDEVVMQTTNPLPYLFPLEHTWISKSTFERFVLTLQGRDARQSFFLTRGAKHGRPTSVLGPLQGPPEAPVHVHSQREACAPFRSEGGFWFCGSWSYGVPLLEGAFLVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3N9</accession>
    <name>A8Q3N9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730663.1">
        <property type="nucleotide sequence ID" value="XM_001730611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3N9"/>
    <dbReference type="GeneID" id="5854970"/>
    <dbReference type="KEGG" id="mgl:MGL_2459"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2459"/>
    <dbReference type="InParanoid" id="A8Q3N9"/>
    <dbReference type="OMA" id="PISAVWR"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="37"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="153" mass="16765" checksum="7BDC558EA2C0265F" modified="2008-01-15" version="1">MTAPATELYAAAYVIKHFSPSGTFAVCDSLYISNKIVIPIGTATTSVGAYIAECQRVLSSMADEGIHFEVSSFIKILTLVQLHGYGTNVEGPISAVWRALQRCHEAVHAMGVERIATDIRLGTRTDKQNDAPEWSNGLTENQRKRESVLRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3P0</accession>
    <name>A8Q3P0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetylornithine transaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730664.1">
        <property type="nucleotide sequence ID" value="XM_001730612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3P0"/>
    <dbReference type="FunCoup" id="A8Q3P0">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3P0"/>
    <dbReference type="GeneID" id="5854971"/>
    <dbReference type="KEGG" id="mgl:MGL_2460"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2460"/>
    <dbReference type="InParanoid" id="A8Q3P0"/>
    <dbReference type="OMA" id="MVPGFKY"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46092" checksum="7A83F669E10404D6" modified="2008-01-15" version="1">MLHRFSETTLGTYVRPPVVFSHGRGMDLYAKLPKENGGNRRYLDFTAGIAVNSLGHADHQIAELAAEQAKQLVHCSNLFLNEWSGELGYRLAAMTRQHGGLGLERNAPPAAQGQDLRTFVANSGTEANEAALKFARKVAKPSSKVLVAFQNAFHGRTMGALSVTPNPKYQSPFMPLIGEVRVGALNNMSEIESLVRDDVAGVIVEPIQGEGGILPAQVDWLKALRQRCTQVGATLIYDEIQCGLFRTGTMWCHSTMPVEAHPDMVTMAKPLANGFPIGAVLMRPHVAQAIVAGDHGTTFGGGPFTCRIAHHVLGRLSEPSLIQNVRAMSEHLVSRLRLIGEMFDDLVQRETCPRGRGLLLGFSMRNAAHAAQVVKLARERGVLFLTAGHDSLRFVPSLNVQQEQIDEAMDVLESALVVLRESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4V0</accession>
    <name>A8Q4V0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730263.1">
        <property type="nucleotide sequence ID" value="XM_001730211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4V0"/>
    <dbReference type="FunCoup" id="A8Q4V0">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="GeneID" id="5854568"/>
    <dbReference type="KEGG" id="mgl:MGL_2645"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2645"/>
    <dbReference type="InParanoid" id="A8Q4V0"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="116"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="294" mass="32617" checksum="0BF57CEE2941FBED" modified="2008-01-15" version="1">MWRSGHRILQSKFSPARIVGCVRVSQNARPLQHKTPWLLSNNARSFSSFLSQQWAAANVREQPGAIEKSQIPPVVPGGAFNSHIQPSDMLSFVNSASFCSYQSKSNPSKALLGSEETLVSHALTHESWMHGMQGHNRRLAFIGRRALKTYLSLFFFDILEHARRTNSSVSDVEYLQNLLSSQQHVDDIASTHHLGIVSAANLCLEKVMRWHSTVRMDPVSGPQESGLFKVRGSCVEGLIGAIYHYKGAQVAQQFFLSRILLPLTEAYMPKAPPLVRERAALASREASDALAQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4X0</accession>
    <name>A8Q4X0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP complex mu/sigma subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730279.1">
        <property type="nucleotide sequence ID" value="XM_001730227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4X0"/>
    <dbReference type="FunCoup" id="A8Q4X0">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4X0"/>
    <dbReference type="GeneID" id="5854584"/>
    <dbReference type="KEGG" id="mgl:MGL_2661"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2661"/>
    <dbReference type="InParanoid" id="A8Q4X0"/>
    <dbReference type="OMA" id="HEITACA"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="122"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="283" mass="31824" checksum="27BC4525ECC88ADC" modified="2008-01-15" version="1">MTIRAVLIFNNYGRTRLTKFYSHLPTDRQQALIQLIFQIVSRRDETSMCNFLDAPELTPFLPPTTENAWTKVKDPTLPNRDVDGENASINDDAELDPWLDYMDEKAPKPEQNLARRWRPDDELRVIYRHYATLYFVLVVDQSENELGILDLIQVLVEALDQSFENVCELDLIFHFDEVHAIVDQIVQGGLVLETNLSQIVSAAQSVQQARASSTNAGTPSTGASPSHSASSTYLPMAWGPLSFSALAEQSSDALGVIQQFGSQYWQAIQSNSSRPSPMRSRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q504</accession>
    <name>A8Q504_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730306.1">
        <property type="nucleotide sequence ID" value="XM_001730254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q504"/>
    <dbReference type="GeneID" id="5854611"/>
    <dbReference type="KEGG" id="mgl:MGL_2688"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2688"/>
    <dbReference type="InParanoid" id="A8Q504"/>
    <dbReference type="OMA" id="VEESCPR"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="133" mass="15021" checksum="E22F10213818D95B" modified="2008-01-15" version="1">MSSTVRTEETNVTSTNLAPTKAEKDEQVSSVKAGKSRATDENVDGDNEEEEEEYNEEEDEDFVEDEEEEDDDDFDDDEEDDDEEDDDDDDDDDDDDDDENVGDSGEGHDEKKTPAADQNSRYVYACVPNSVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q538</accession>
    <name>A8Q538_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730332.1">
        <property type="nucleotide sequence ID" value="XM_001730280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q538"/>
    <dbReference type="STRING" id="425265.A8Q538"/>
    <dbReference type="GeneID" id="5854637"/>
    <dbReference type="KEGG" id="mgl:MGL_2714"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2714"/>
    <dbReference type="InParanoid" id="A8Q538"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052969">
        <property type="entry name" value="Thr-specific_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763">
        <property type="entry name" value="ALPHA-PROTEIN KINASE VWKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763:SF1">
        <property type="entry name" value="DUF659 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="40295" checksum="94A742920814839D" modified="2008-01-15" version="1">MKENLNGLFAAGGGDGPEAMTAALKAAADLDWRPHAAKMAILITDAPPHGIGEYGDGFPNGSPDGQDPIVLARKMSAMGISIFVVACEPALSGYQHAVDFYQGLVSITSGLLVPLTTASLLSHVVIAAAGEVMDLDRLHREVGDSVLERMKGLSLSLGNEATDSTSAISRLVDQVATELHEKLLLRQENTKQLIIESIYRESEESTHNIRVWSHAPDIFTARPHIRKVIGSRLSQKYLDMRRASQQARLWRPTPTPLSGALNDEPTSTPKRQIVSQFAAFEAKPGLRVQASPNPPTNVTNLSTGTYRSSGMDMDDDGDDAFIADSGIDDRTGTSHDNEVRVEGDDGQMLAYRHDAISLSQARRLAMQSLSRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q554</accession>
    <name>A8Q554_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730344.1">
        <property type="nucleotide sequence ID" value="XM_001730292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q554"/>
    <dbReference type="FunCoup" id="A8Q554">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q554"/>
    <dbReference type="GeneID" id="5854649"/>
    <dbReference type="KEGG" id="mgl:MGL_2726"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2726"/>
    <dbReference type="InParanoid" id="A8Q554"/>
    <dbReference type="OMA" id="KVRWACE"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="306"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="53918" checksum="6672AAE3A377378D" modified="2008-01-15" version="1">MALALGLGSLFNHHPSSANVSFELDKSTRSIRYRTVRQISTGEELCICYGSGKMWWEGPDEERPSTPVSETHEVSLFGQIGLEDDEHEPATTSSTASQTPSSRVLSNSHSKAPVLDASYKAPLWRITSSPDPKTMQLHTTRAWAMDIPPRACSPAAQILKRLVKNGSLRAGDVHPKYSIRYLRSFRKAKDVLKLPQEKYDADSMDLSLLLCLEDAHSSKDLTLLLENAFGSLHIPIRLYLVRVPTGPAPSPERLSEWSAIWPCVFLPPGAGIPAKDGVPGSDAARAMVPVDRQADAQLWSDESLVDRVRHAFRRCIATAQQARAAGELGIGVFVTNMEQDGSIAISVDAHDTRIRDAHPLRHAVLNAVRRVAHIRSQSRSSTNEEAENGQDYLLTGLTMFITHEPCVYCAMALIHSRVRSVFFLFPSPRSGGFCGAQSNASDICDGGQDGGPFCIHEQSGLNHKYEVWRWINPAELVHVQIDMHMSVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q588</accession>
    <name>A8Q588_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730370.1">
        <property type="nucleotide sequence ID" value="XM_001730318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q588"/>
    <dbReference type="STRING" id="425265.A8Q588"/>
    <dbReference type="GeneID" id="5854675"/>
    <dbReference type="KEGG" id="mgl:MGL_2752"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2752"/>
    <dbReference type="InParanoid" id="A8Q588"/>
    <dbReference type="OMA" id="RIHICIA"/>
    <dbReference type="OrthoDB" id="3351580at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="723" mass="80033" checksum="39116D65F5295DBB" modified="2008-01-15" version="1">MVMYEDVLTPTLAYTDARELCVDIAALFAGSSLELAMPPASMIDEYACLFYDEHIRVQLTMKLPSLPTMLPAPIHMFSDVHTLDDHSVMTLPPLLVILLSSLHVSLRGSMCEEKETKTPASLFVHYWQRLPSSTDFVLRRSPLTRIQRPETEAVEPFLDKSFVPGITYDTQQKSWVVRWTSDVNVPYTMTDLPRERMKINAMLQLRLELALLAAQAQAAPPQMPFHYSSNRQHPFSQSSDPYIIDVDLLSDLADTVKVPDETPEQRMQYLSKRLTMMPLSMLAPGVLGTDITAPWGEASSLSSRLNHIKELEAAARASDADIALAPLSHSARFGPRLPQRLSSTPVGVASKPREESATMSSTTDIATLASQGPVSLTSMTHTFAVVCASTAVRMRTLSRTLPLDTSEDAQSVVVCIELDALPMTIPFWVHALHLDMGERSDMTRETGFMSMNDPVQIVIEPLPGHASSLPVCLGRHAQHNMLYTVRLRISSEDLDAQTLARQLTTWDPHRSTRVTMLGTPERGPHTSTHSTCVSQWNGFMDLSLALLDLQRRSFAEHIIRRSMGQIPKPWTPDTPPPPTAGDASLAPMALSASRNVEPVRLEETISYDQTREGAQGVSIKDADGRSKSTTRHAVGWSESHSQRIGFDPTRVSSFASCLLASLKTYQEPTEAGSHRIHICIALSNVSPDPMDIQVSWAMDLEPAPQKNRAIVAEHSSIRVGYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5J3</accession>
    <name>A8Q5J3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729799.1">
        <property type="nucleotide sequence ID" value="XM_001729747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5J3"/>
    <dbReference type="GeneID" id="5854100"/>
    <dbReference type="KEGG" id="mgl:MGL_2785"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2785"/>
    <dbReference type="InParanoid" id="A8Q5J3"/>
    <dbReference type="OMA" id="LQYGCLA"/>
    <dbReference type="OrthoDB" id="2524788at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="215" mass="23435" checksum="70F7367D55D38D63" modified="2008-01-15" version="1">MSLMCSIALIMNIKPYAPRKEGTDMSSNAYASLWCVSNIMLTRHQFFSFYDYVLGGPKNDQAYLLTHRGVQGAQISSVAATPVYLLNAIRNRRFALKGLARYNWILPILGAGIGAGVGWAESIQISAPLLAYRTSAVRADTERMRRDDFHLIGSVVGALTLPALFLRHVGLFHGILGGASLGGATGVLTFYGKRYSEDSLPDLPIPGTEQKVELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5M8</accession>
    <name>A8Q5M8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729810.1">
        <property type="nucleotide sequence ID" value="XM_001729758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5M8"/>
    <dbReference type="FunCoup" id="A8Q5M8">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5M8"/>
    <dbReference type="GeneID" id="5854117"/>
    <dbReference type="KEGG" id="mgl:MGL_2796"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2796"/>
    <dbReference type="InParanoid" id="A8Q5M8"/>
    <dbReference type="OMA" id="NYSKWDQ"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="200"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="406"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="501" mass="56578" checksum="A468300F014E442B" modified="2008-01-15" version="1">MGKLNYSKWDNLELSDDSDIEVHPNVDKGSFIRWKQRDIHEKREMRKIQRSHLEAEHRTNVAVAPILENLSKATEKEGAAYYSREVSRLTAGRQERGNKDGPEGPTLDDIMLSLLLKINEEADVKSSHGTKELDSVLVSAIQRHMQKLEARTNEISSELKRMDEEDRKKITSDSLREGWNSSHVTKIEEPPTKKNSWPPNKGKVHQQHIETLNPSSAQLSSNPSSHGPRKADDSDDEDNMPTITPVMKDFASLPSALEPIPLSTDKFPPGFNPAKQLKLDAFDKMFQYLGSHKELLRPDYGTSDALLVQAFEAQMAGQKSLARMCTEKALLIQYCNQLGKDGVSLFFQRMTNTDGRAAVVFLNDVLSTYARIASRANVMKDRYQAEGEGEEQIQLMAEDPNTVITFQIPDGPPPNEIKLEGDGADTLDPAHVREWLQRRWDIFNSFDVDFRRALETKDLDQVNQALGRMPVAQAEVVVQDLDRAGILNFRSTEIRDETGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5S4</accession>
    <name>A8Q5S4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_2811</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729825.1">
        <property type="nucleotide sequence ID" value="XM_001729773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5S4"/>
    <dbReference type="FunCoup" id="A8Q5S4">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5S4"/>
    <dbReference type="GeneID" id="5854132"/>
    <dbReference type="KEGG" id="mgl:MGL_2811"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2811"/>
    <dbReference type="InParanoid" id="A8Q5S4"/>
    <dbReference type="OMA" id="MCGWDDN"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="749"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="815"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="403"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="474"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="541"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP42611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="856" mass="97728" checksum="22F6313B2F62D389" modified="2008-01-15" version="1">MSTGGATSYRPGHIEPLLLTSRNSWYPVSSQATTTIDSPEGDSSSDVDLSTQQSGSILPVHTNTSKLVDMATHFDEDSPRARLLSPGTVPPKERDTRSSKLSKYAQAMPLYSPPMPFFERVKLAFQNDTYMIIMYTILSFITRLYRIGSNPRVVWDEAHFGKFASYYIRHLFYFDVHPPIGKILVAVAGWISGFDGNFEFDSGGDYPAEVPFVKMRIIMALYGIAMVPIAYMTAQSLNWNWRSKHLFTIMILLDNGLLTISRFILLDSMLLGFTVSTVLGLVRFHRMQKQPFTPMWWFWLLFTGVSLGLVTGVKLVGLFVTALVGLYTVEDLWNKLGDLRMPVRAYLRHWCARILALIILPILLYMIGFKLHFLILYKSGSGDAQMSSLFQSNLEGSDLSNFPLEVAYGSKLTLKNMAYGGGLLHSHIQTYPEGSHDHQVTCYHHKDENNHFIISPTYEDPPLPAADENIDEPPRMLKSGDVLRLVHQQLQTNLRSEAIPAPITKEAHEVGCRASEKGADSSEYWIVEVLRDVHLGPGRPGMPIRTLSSTLRLRHKELGCYLRSGSAVLPDWGWKQMEVTCDPRNNPKDIGTHWNVESHWNDRLPNVETRQRTRSPFLKDFVHLNVAMMISNNALVPDQDKFDHLASAPSEWPFLYRGMRMNGWGADNYKYYLVGNPVIWWGSSLSLIVALPVLAWYIMRRQRRIHDMPPKVWDDFLFGLKVGWIGWFLQYFPFLMMGRVTYLHHYLPTLYFAVIVLVHLLDHYLWNDATARTSIDWPTLLRSGRIASTKLNPFVHDTAAAVPGRPLSQHFKNMSFAAVTGLVVGVFFWFCGVSFGMYGDISKWPYLKWRKNWDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q645</accession>
    <name>A8Q645_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729865.1">
        <property type="nucleotide sequence ID" value="XM_001729813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q645"/>
    <dbReference type="FunCoup" id="A8Q645">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q645"/>
    <dbReference type="GeneID" id="5854172"/>
    <dbReference type="KEGG" id="mgl:MGL_2851"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2851"/>
    <dbReference type="InParanoid" id="A8Q645"/>
    <dbReference type="OMA" id="MTQWDIK"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="155"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="260"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="357"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="473" mass="51270" checksum="F5936D9E389DCBDA" modified="2008-01-15" version="1">MSHAYGGGDYDDTARYSRRRYPYDASEGRSGGGSSDYDRRWRRGGSGHHQRGGGGGGRRSVVRTSPPPPGTIRLSDRPIAHSQWDVRAPGFEAVDALSAKATGLFGAPVNSGSSGMMMYGIRGAMPGTIPPSAMAELEATTSAAAFNASMYLETRRLHVSPVSSVKTSQQLRIFINAKMNERLLCSSGSLEPCYAVDMHLDEGYAYLEFRNPDEASNALLLDGVAFLGHRLHIERPKGYVGQDAVPAPGAIETSVPDGPNKLYIGNVPVFLNEQQVMELLKAFGDVRHFDLIRDPETQRSRGMAFCEFHEDAVTDLACEGLDGLEVGEQRLMVRRVNASTNTHTHEDTQETSDTPTRAMLMLNMVTTDELLDDTEYQDIKEDVHSECSRHGTVTSVYIPRPLAAAAGHATSADAASGMEPKGVGRVYVQFVHADECEAALRAIAGRQFDGRTVICAYVRDDAWPQAAAEAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q694</accession>
    <name>A8Q694_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729904.1">
        <property type="nucleotide sequence ID" value="XM_001729852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q694"/>
    <dbReference type="STRING" id="425265.A8Q694"/>
    <dbReference type="GeneID" id="5854211"/>
    <dbReference type="KEGG" id="mgl:MGL_2890"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2890"/>
    <dbReference type="InParanoid" id="A8Q694"/>
    <dbReference type="OMA" id="HYAWIKS"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="3">
        <location>
            <begin position="496"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="669"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="669"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="838" mass="90983" checksum="445BC6996CC728C2" modified="2008-01-15" version="1">MLKDAHAAETRELQASRAALADVETQLEKAREELSAFVSESEEKLSAQDKEHQATLEQLRTQHASELASLQSTLDRERETHLAEQQKAIDALQKEHKSAVTSLIVKHESRIAAARDERLHSAEATIGQLQSRRNLADKEHSTWREALEKEHAQKLGALTHEHESVLDALRLEHESELQHAQTQHSDALDALKKEHASHVASLGLENEEAIKALAATHAQELNDRLRSLEHQHAERLASMSAAHEEAIRSAHSEQAKQREALHDAEMRLHLLTSKVAEAQNALAEMRNEAAEHRAAAEEARAKLIDQSVLHPDTTGATTSSAPDGDDTLRAAEHASQLQASQDRAEHYMALASELRKQLSLKEAEMNAALRAKEREHEAPLAELADIQAERAHLLQQVVELSAQLREARAAAAMTRAPSLSSVAGAAPALSWAGSQATMSRSPSTVTSLYASPEGSRGHGSSVGDDHGEADVPAWVGGQASMPVLLPGHMNNIDPEVADAIIQCMRGEWLYKYAPQRRLLGAERRHKRYFFINPFNRTIHWTSEEPKASAGHVARSKNAFIEQVALMDDYNSNPSGLYYQTIVIRSGHREVKVTAPSKVRHRIWCTALGYLLQSSDSPVMGVSAASSDGTRVSIPVELGGRGPTTSRSKTLLHRTQSLRNTANTRLRALGSASTLASTSSSAAPAAEHHGPSSPLSTRISTQAAPSSPYAAPAQPTRESTAPSSSRLSLVTRSMHLPRSPFSSSSATASSVHPVVNEHPHPAAGTQQRIPSAWRSTRRSNPDKRVLSGPGAAPPVHAAGIMESQAAEVIHNLPPPVQAPPAIVSTSTPSKQSTRKSRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6A4</accession>
    <name>A8Q6A4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729914.1">
        <property type="nucleotide sequence ID" value="XM_001729862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6A4"/>
    <dbReference type="STRING" id="425265.A8Q6A4"/>
    <dbReference type="GeneID" id="5854221"/>
    <dbReference type="KEGG" id="mgl:MGL_2900"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2900"/>
    <dbReference type="InParanoid" id="A8Q6A4"/>
    <dbReference type="OMA" id="THETDMN"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="614" mass="68250" checksum="041AA30FCFF52AE1" modified="2008-01-15" version="1">MDEEFVHFNDHVGILPRAARQIFQALHENSELDQDECTVSVSFLELYNEDLIDLLSDRDNERNTVQIRETRTGDIVWMGLQQRTVTSAYEVVSLLQQGMKMRKTHETDMNAQSSRSHAIFSVTLTRKRRGTANSAMERTPSTLGRQSPDKTFTTPRTPRSGLPTLGGRAPISRAGTPTRPSTPTRPTASRGVGACGTPQRRATDDATCVTTTSKLHFVDLAGSERLKRTAATGDRAREGIAINSGLHALGNVISVLSDPVRTKRPSHVPYRDSKLTRLLQDSLGGNSHTLMIACISSAEGNAGETLNTLQYAQRARNIRNKVERNQVEQGWDNIEYLQSQVLSLRHELELVHSSKELVISSPKRPARLMPSEHESELLAWQEKCSALSRKNVQLSAQLVQREQERRGTSVDFLQAAEPVIVEYEKAVDALEGQINMLKAAVSHLEQVIQDQSTENLSLSDRATSAERQLDVLRGSVRDMHERLDERNARVEALELQLRRATASTTSTTPLSFRTSRSSSASSDAPFTTPQRPFGGILDYKGRSPGKRTYRVATQGRAKSELDTYANRQTGGGDGVESTRRMSPSEQPLSKRHVSDTTTALDRERAAYPVEFRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6C6</accession>
    <name>A8Q6C6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729936.1">
        <property type="nucleotide sequence ID" value="XM_001729884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6C6"/>
    <dbReference type="GeneID" id="5854243"/>
    <dbReference type="KEGG" id="mgl:MGL_2922"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2922"/>
    <dbReference type="InParanoid" id="A8Q6C6"/>
    <dbReference type="OMA" id="MCLQVPG"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41457" checksum="F739BF00BE52C177" modified="2008-01-15" version="1">MEKDTCKLPPHDAATWTLSAIVCIGVVASYVPQIVRIVSARSSVGLSPWFLFLGTTSSWCATFNVLVLQWPLLACTLKHVSWMHVEYWMGLLQTGLQQLMFTILFACFLYYYRLEKVPHRRRSRRRHSTRPVRKDTDTSLLHPPEQDGNDSSGSESDLESYHSHIHQSYGAVSNSDHGHAADTLATHARSHDDYMNIPAHMRHILERHLLPSEEAIHGKVGSVHEFQLSRQLAWVATILVLIIVILSVVMLGSHARRAQVLPWAAFLGVLGGLLAMCQYLPQILHTARARLVRSMSILTMCIQVPGAFVFIYTLHGREGINWSSLLPYVVAALLQGILLVLCVAWKLRQRQEGLDDYGRYIGTAALHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6Q1</accession>
    <name>A8Q6Q1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730044.1">
        <property type="nucleotide sequence ID" value="XM_001729992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6Q1"/>
    <dbReference type="STRING" id="425265.A8Q6Q1"/>
    <dbReference type="GeneID" id="5854351"/>
    <dbReference type="KEGG" id="mgl:MGL_3030"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3030"/>
    <dbReference type="InParanoid" id="A8Q6Q1"/>
    <dbReference type="OrthoDB" id="3360284at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="432" mass="45314" checksum="874834467B6ADDFB" modified="2008-01-15" version="1">MDRDVMAAASAAQATTRTPFDDDDEYMGGMDNAAGGPFHTPGEGSGSNGASIDGNGGNVMHPYYSTAFNQSGYHQPEHYLNMVDDPYASSLNGSGNAGAGPALGMGGLAAPATQYYSPHRGPSMSSDSQRGYYESVPTDLGYNNNNTNEYNFIQRPSFDSVPYGAGSSAAAYAAAPQDPFRDSSEPDSTRVMPTLPSMGGISGGSGRVSSASEYEPAHSTMGHQQPVSLPNMPQNSVQPTALHNMSNSNYNHNLMDTQHVGGVPNDQNSGVWPPYVSGAAPVSYNAPSASTSAFSTENGMVNQSAVADRAPAYDPGDNPPHVSDSKQIPVSMPREGSSDNAVTQFPPERANGVVQAFGGDNEGQSAFDHGDWDPPALSSAWFPTSVGDQPGMLQGLHTQQQGPINFSDRDVPTPRASAQNLMVRNPSPEDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6U2</accession>
    <name>A8Q6U2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_3054</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730068.1">
        <property type="nucleotide sequence ID" value="XM_001730016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6U2"/>
    <dbReference type="STRING" id="425265.A8Q6U2"/>
    <dbReference type="GeneID" id="5854375"/>
    <dbReference type="KEGG" id="mgl:MGL_3054"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3054"/>
    <dbReference type="InParanoid" id="A8Q6U2"/>
    <dbReference type="OMA" id="KWERNAP"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP42854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="121" mass="14550" checksum="4F7C1A6315F19FF9" modified="2008-01-15" version="1">MFATTVRLTSAPPAFSELHKKYVMNLYRRYLRDSLNWHIRRDAWRKDALRIRAEFEFNRHVRNPRELASLLNRAEAQLESRQHPDPYKPPTYVGGVKWERNLPPRLFTDEEKTESLKDQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7C1</accession>
    <name>A8Q7C1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TrmE-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729778.1">
        <property type="nucleotide sequence ID" value="XM_001729726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7C1"/>
    <dbReference type="FunCoup" id="A8Q7C1">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7C1"/>
    <dbReference type="GeneID" id="5854084"/>
    <dbReference type="KEGG" id="mgl:MGL_3322"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3322"/>
    <dbReference type="InParanoid" id="A8Q7C1"/>
    <dbReference type="OMA" id="EFHCHGG"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116878">
        <property type="entry name" value="TrmE connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GTP-binding protein TrmE N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="MnmE helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="5">
        <location>
            <begin position="186"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="49356" checksum="A51B8744ECF6A1F8" modified="2008-01-15" version="1">MRRSIIHPQTQELLDDALAVYFPHGRSFTGQATLELHLHGSPAVVRDVLEALDAMRTVLSTRDMRPALPGEFTRRAFEHGRLDLTACEALDSLLHAETSQQRRLAQWAAQGYQAQLYDRLYAQLVQAMSQMEAMLDFSDEDDVNEHLWISVHETIHGMRQYLASELQLNTPPTRRSYADAVMQGVRIALYGRPNAGKSSLLNRLVRRDAAIVTPYAGTTRDVLEVCMELAGYRVTLADTAGVRASQDAVEQIGVERTQAYVAEADMCVLVCTPQDFQHDLPPAGPCRIPAATLERLGVQMQAKPVLILINKMDECWDIGGDHTSSPLSKGRCDHEGVECHVWHASVLHDVGMDLLMNELGSHVARMYDTNQVTMPLVTQARHRHILMDVVACLDTVLATRESPDLVVVAEELRHAAHLLAQVTGRTITSDTVLGEIFARFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7W1</accession>
    <name>A8Q7W1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial dicarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729596.1">
        <property type="nucleotide sequence ID" value="XM_001729544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7W1"/>
    <dbReference type="FunCoup" id="A8Q7W1">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7W1"/>
    <dbReference type="GeneID" id="5853902"/>
    <dbReference type="KEGG" id="mgl:MGL_3140"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3140"/>
    <dbReference type="InParanoid" id="A8Q7W1"/>
    <dbReference type="OMA" id="IMPALNW"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="107"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="204"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32422" checksum="A9D8F9DD593E6ABE" modified="2008-01-15" version="1">MAQKQPQTHHKTYPFWLGGVAASIAVCFTHPLDLAKVRLINSPEKMSTWRVVSTTLRNEGVRGLYIGISASILRQMTYSLMRFAAYEELKTFIAHRNDPTQPISMWTKIGVAGLAGVAGGIAGNPADIILVRMTSDMFRDPAQRFQYKGAINGLVRAVKEEGAHVLFRGITPNMVRAMLMNSSQLASYDFFKETLQGTGLFTPGSLVHYLTSSLLAGTVATTITSPADVIRSRLMNARGNDSGIPQLLHAMRTEGPTFMLRGWLPSWIRLAPNTVILLTVLEKLRETVDFVRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q810</accession>
    <name>A8Q810_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729633.1">
        <property type="nucleotide sequence ID" value="XM_001729581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q810"/>
    <dbReference type="FunCoup" id="A8Q810">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q810"/>
    <dbReference type="GeneID" id="5853939"/>
    <dbReference type="KEGG" id="mgl:MGL_3177"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3177"/>
    <dbReference type="InParanoid" id="A8Q810"/>
    <dbReference type="OMA" id="KIPCHEL"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="91" mass="10061" checksum="AA4B1F422D4DBA8E" modified="2008-01-15" version="1">MLCALIRAPDWNVRDPDDVCGICQNYFDGVCGACRDPGDACPLAIGQCTHEFHLHCITKWLSEKHEPLCPLCKRPWVQIGPTSEAPIAKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q862</accession>
    <name>A8Q862_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1214 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729666.1">
        <property type="nucleotide sequence ID" value="XM_001729614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q862"/>
    <dbReference type="GeneID" id="5853972"/>
    <dbReference type="KEGG" id="mgl:MGL_3210"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3210"/>
    <dbReference type="InParanoid" id="A8Q862"/>
    <dbReference type="OMA" id="AMIITVP"/>
    <dbReference type="OrthoDB" id="3431965at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727252" description="DUF1214 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1214" evidence="2">
        <location>
            <begin position="306"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="443" mass="49910" checksum="F33EA0BBCAB0A7AC" modified="2008-01-15" version="1">MTMWQTLVAGGILAGTVLVHASNPLATEDQHHIDELSKSFLGRGNLDALKQKAREQYVKSLKKYNVELTGSVNKDLDAAMDELVFSSIQKAANGDPANPKVYWTDTAKRTHDWFGISVPGGRYSYDNPDCIYRTIPISSKYKYKISGRRFGNGTADQSFSLIKNRNSQNTISALYKDDMKVNSDGSYEITISTDKSGGQNHIKSDWTAKQLFIRNNLGDWSKETPDELKVEIIDKPKHAPKRTDSDILKDAQEDLKESTFFYGFGALDLKTLTQKLNHLASPHQSSWLGTLTSQAQSFGYFHVKPDEAFVITLTSGKSSYWVMPVTTMGLLTKDPEHNIVSFNNFQSAQNKNGSYTFVLSSQDPGIYNWIDTTNLERGTLMIRWQGLPAGDGTAKDIHVHSQLVKYENLHNVLPDDVPKIDQGGRSEQIEKRRQEYKRIHFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8A7</accession>
    <name>A8Q8A7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729692.1">
        <property type="nucleotide sequence ID" value="XM_001729640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8A7"/>
    <dbReference type="STRING" id="425265.A8Q8A7"/>
    <dbReference type="GeneID" id="5853998"/>
    <dbReference type="KEGG" id="mgl:MGL_3236"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3236"/>
    <dbReference type="InParanoid" id="A8Q8A7"/>
    <dbReference type="OMA" id="CPYAHQS"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55816" checksum="AA02040C40A1251C" modified="2008-01-15" version="1">MATLSSLTLELGTPDASRVQEAVQRVLVEHDLSSHDDTVMAEYVTVMIANRKGPAMIADELRELVGGDLDASVTRALWKSACDILAPAAELPSSLHNEQHQQQPELRRQRQRNSESYQPQSKHRSRSRSASPPRSRAQQQASPAAASNERWDGEHRRSDRSTSKASKRDVELFPSSKERRNNKMRSDDKPASVSILGRAGVPDPRAPPFMPPFPEGMAAPFPDGVPPPFAAMAAMAAMASGGPSLFARLDPMMPNNPPPMPGAGLTISSTPQTPPFGLPGLGADSFPNGPPVLRDIAAFPTKPSEGALCRWSVQCTNPMCPYSHPSPANAGRDGDPSALVLKADICEHATDCADKECVRSHVSPAVSFIKARGSVPPPSGVTPCKFQQSCLNPACTFTHFDQQGQVVPPPGQMHAAPGPGSTAATSIPCRYGTGCTRPDCVYMHPMRSTVPSQRSHVPCRYGDGCTRPDCYYTHPRDGPRHPTSERLKAFATDEEDEDRERIIPGEQSGDLTTPMLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8C7</accession>
    <name>A8Q8C7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3247</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729703.1">
        <property type="nucleotide sequence ID" value="XM_001729651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8C7"/>
    <dbReference type="FunCoup" id="A8Q8C7">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8C7"/>
    <dbReference type="GeneID" id="5854009"/>
    <dbReference type="KEGG" id="mgl:MGL_3247"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3247"/>
    <dbReference type="InParanoid" id="A8Q8C7"/>
    <dbReference type="OMA" id="WHEADET"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="202"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="59972" checksum="48794D015536532C" modified="2008-01-15" version="1">MHATWHEADETHIAPLVQSTSAASVPDNYMVVLKPEVTTEQFVKHREHVAYASVLFSLLHDKSAMSGVDFARIMQTQENGIGSHWPAQEDVGLFRHIFDMGPHLQGYAGRMDASFVDALRRLPEVDYVERDSIVDVTMLKQDDRSVQDMPLDSSVSASTFPWDSPYQHLTEDGAPWGLARISHRKSLSLGTFNKYVYESIGGEGVTAYVIDTGVNIAHKDFEGRASWGKTLPLNDTDIDDHGHGTHVAGTIASKTFGVAKKADIIAVKVLGSGGQGTMSDVTAGVLWAVADAQNKTREIMNNPNSAAARKHRGFVANMSLGGSKSPTLDRAVRGAVKAGMHFGVAAGNEAQDACFVSPASVETAVTVGASTIADEQAFFSNTGPCVDIFAPGLNILSTWSSSPRSINTLSGTSMASPHIVGLMAYLLSIYGTDDFTLIKDAVPTRVAPAAAMHQADTHGLRETGRGHGEMSARRRLLQVLQKLMPSWMPSLERLFPQVPVLSTEMEQGLSIESALRPADLKKAMRRMAISNALEQLDPETTNKLAYNNATTTNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8I7</accession>
    <name>A8Q8I7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729734.1">
        <property type="nucleotide sequence ID" value="XM_001729682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8I7"/>
    <dbReference type="GeneID" id="5854040"/>
    <dbReference type="KEGG" id="mgl:MGL_3278"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3278"/>
    <dbReference type="InParanoid" id="A8Q8I7"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="226" mass="26383" checksum="3F919306DC19D833" modified="2008-01-15" version="1">MEEAQENMAYLLDPLSSLATYSATDRRPTGDLAFHYWSRSAMQESSWAILRVCDYLRHGVPLAKNSQEAAFCYRKQARKENFYYFFGPSERFASLRLAELYETGLDGVLHPDFLASIRMYDWVWSRMEKSGQNSFLSFVVWMQFRVYLRAIMAMLHGDISARQFLLRSLTPQMRLPPWMVLFSFSVSHDTMLALVGLTALCILAVIRYQLRRRMINLHAQHGQAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8J5</accession>
    <name>A8Q8J5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729738.1">
        <property type="nucleotide sequence ID" value="XM_001729686.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q8J5">
        <property type="interactions" value="484"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8J5"/>
    <dbReference type="GeneID" id="5854044"/>
    <dbReference type="KEGG" id="mgl:MGL_3282"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3282"/>
    <dbReference type="InParanoid" id="A8Q8J5"/>
    <dbReference type="OMA" id="EGLMAMF"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1813"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="2452"/>
            <end position="2715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2515"/>
            <end position="2568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2695"/>
            <end position="2734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2515"/>
            <end position="2558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2559"/>
            <end position="2568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2697"/>
            <end position="2728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="2734" mass="303236" checksum="3122E43EAB18398A" modified="2008-01-15" version="1">MGDSAGIHRYVSFHERLKNVTIDLSRDASHSWGQNRLQVAGLDAPASVFAEATGTATTIAETSDLQSTAFGTALEQWNELNLSLPFQEFYALVKPKAQSLVLLLHHRDEIATVLDASLILRDDRSWLAWDALLDLVPRMAFDLGPEFLPVYPKLLTALLRASSSMNKNLTHGDDAMAARLVERAFHSAAWLFRAVTSLMLKSQSPELLITSWTIVRDVIAAEKPSQPLPAGANENINEVADENEEDKDEDREENIEEGENQVLVHTSQLSPTTHTRRFATEALSYLIRKAPQAQLKELVSHMLVDANCYGLALEHGIAATWANSCKTASHALHSRTPELLSCIMDLESPCAMMVRRIGRWIITSLVHHTRAPGMVCVFDFLLQRASSLQPGDALQSMLEWLIAAIGTRKGKRVAEDSLHQVLVFLADLDEHLPWTEAHASLLQSYITLVCLSLPKAHVRDMTGPGKRLLQAFVARPKEEYFDMPWAALAGMFRVLGDPATAWHGFSTFALPHALEATSRVLEDDAPNAHQDSALALLSVLDTQGHLDPMLHAPPTTIVLRWIKRTRRIVQKRLEQLAGRLETGSWTDEATVSLPAVQLACRFPQFAAKFVPLLVQCIQSAAAMGLESGALGARSGAAVIDMSAVMGALVAGLVHLLQASDVPKEPLSFLFDGMPSTFETLLRACASNHAVLPALADLACIAHVQSVRLPGAALTWSMLSAAVLDANRAVVLAALRIMSLTIGDVPVRVMDMLVDVESMGLEVQTIATRNVKLRHIQREACKVLRADDVQMQALVYYTVGTLKINFQPVWAASRETLVALCSRVPEEVWRVSFAEWQAADALIHAGTTYIQDHQAGEILDTAMKSDSAFDDTVDTDTEDAFSLHDAQRQERVRWILRCMQMESVTAVEHARYGLAERSNARDVRLDVRHYADQLLRVYEKHAMLPEKHSEAFVSAVIAQWSSLVDDEAELELASASTPTTGARMPAVMRAERLRRFLAIFAEFRHPASMYKSPAMKSRFLALCANPELAIQRGAVECLLAWKDEWLVLQEDTLQKLLDPAKFRDTLSHLNLAASSEQFSPTDRPHVMQVLVRLLYGMMVSRRGARTSGAGQTARRSAILASLYESSEDDIGLLVNLMLGSFSDLHATPLSHSDVFVVPAKVPQALPRKQLGLLATMGDVLRHLGRPLTFCLPRLVAVVVTIDAHASESSDATMRMIRRTAFRRLADFVRLAPDVDWHPFRTAILSKLIHPRLATFADDSVQAPSSLLDVCCAWVSRPDTLLCFMSDPSVLRSVYAGLSRPSIKPSVVHTILDMAERILHAGQGLHGDQNDMADVSDIHTTQAIHSRVVVPTSSSLLEHIVPLVRHTIHSSFAHPLSTQVRDEMLRKQLSVLSQLAPHLTSSDDAAAVLSLLVPLMQHGAKAVPERVKIELLRTLSLLLPRASCEGAALDDLYTLFCRLGAELRWQPARMQYAQAFAQLAQKDASLERITSWVSRLNAYSARTLNEPDLETRLLAFDAILDPHTQIDVREWHALLYEALFFVMDEELVLRTNASSLIQRFVSEAQSEQALSLATDVLLPGVYKRLHTRVETVRKELLTILGLAVAHWADVLPSLTELQVLRAGGDDEASVFTNLYHIQTHRRVRALHRLGDAAEAGSLRSRTLSELFVPLVWLFLLPNQSGGIDMNMANEALACIRRMATHLQWGHYYYWLKRFLRQLKEHAGKDETSASERLHVRGIVGVLEAFHFPMDEDVEMSDDPIADESSTQAPPHAIAHDLTLDTADARSLPRAQRLALATTLTTRVLPPLYEALATKDEDRLPARLPLLIGTARLAMYLPSDRRNVELFKVFSELGSALRSKLQSTRDTCRDMGVQMLRAIGASYLPDVVHELRRILTRGPQLAVCAYTLHTLLVALAVPAVPGTAPLLTKLDRGVRDMTEAVMEDLFGLTSEDRAAVEYKTKVRELRQSKSLDSFEHLARLVDPRSLQELLLPLRGVLATSIDPKTLHSVNECLHRIASGVSANPHIDTSSYLILCYTLIARGAKALAETPPSEAPHLAQNAHFFVELGLDLLTTALRRSRFDIHDEATVSKLLPLVKAVGETLYARNAPVVERGLRAVAALARCPLPNLDETLPVMQKQMLLLLRHAGGIHSSMAQTTLRSLSVVLREGRARAPPARQLTELLNLVSSELDAPDAQTSVFALLRAIVSRAFVVPEIYDVMDRIAELLVTSHDAQVREICRSLYLSFLLDYPQGQGRLRSQLEFLAKHLAYESESGRRSVLDILGAIMSKFSTDVISQYSQLFFVALVMQLANEDSPHVRRHSADVLGTLLRTVHEKERDALLRMAKGWAMAHGSDQAQKLAAVALRVYDIAHAQSACPPWAIQDASEAISQALYDSAQAMSSDSADPDSISWQLTYQALQTMQTIVLGDPKAWSRFDSAISNVVTLLTWPHAWCRVAASRVMGAYFAADMHMEANELIRTARQLVSQLYSAFLDDALTLQVVRNLVFLGKAFARGDAMEADDDEQDSDDDEDEGDVENDGEVDVEFDAAETLDANDNDNEHDDTHVDDSEKPSPQLAWLFTKLSHAARLSHRGGRSDTAPQRVGAVLKWFAAMATQLSASIISKFLVHILSPIQRVMDDDQAPEDLSMLATEVQDLIQAQVGPTVFTRAFAHVKQARLNKRRERKHERLFETVMDPERAAKRRASRNAAKHQSRKRKHAHYRDKRQSNKRTKAVEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8K9</accession>
    <name>A8Q8K9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3289</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729745.1">
        <property type="nucleotide sequence ID" value="XM_001729693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8K9"/>
    <dbReference type="STRING" id="425265.A8Q8K9"/>
    <dbReference type="GeneID" id="5854051"/>
    <dbReference type="KEGG" id="mgl:MGL_3289"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3289"/>
    <dbReference type="InParanoid" id="A8Q8K9"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="302" mass="34621" checksum="01785C06150339CA" modified="2008-01-15" version="1">MSTGTQDTNAQSMHALPKLEPIDARNESVQKLLTRPHKCILSDLDMLVWERSQAHDCILLFLMHLSEACTGCPTRDVVWDNYTTYSTSKSIVDRVLALLIHLDSWTDEIEPLSGPQRFGNLAFRSWGARLAERINELHQSCLPDYLHIYTIELCSYLMDAFGSFIRIDYGTGHELNFIAWLAYMYRLGAFQEEEFLEQRLALEVIPAYLRVSWHLQDRYSLEPAGSHGVWGLDDFHFVPYILGAAQLRDTCMTPSEMTDVSLYPHSRQREPRVGPRLTPQATLFYKPPRSLTPLPNILYGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8W4</accession>
    <name>A8Q8W4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'-5' exonuclease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Werner Syndrome-like exonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729316.1">
        <property type="nucleotide sequence ID" value="XM_001729264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8W4"/>
    <dbReference type="STRING" id="425265.A8Q8W4"/>
    <dbReference type="GeneID" id="5853623"/>
    <dbReference type="KEGG" id="mgl:MGL_3351"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3351"/>
    <dbReference type="InParanoid" id="A8Q8W4"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF109">
        <property type="entry name" value="3'-5' EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="10">
        <location>
            <begin position="102"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="348" mass="37930" checksum="C7E40EF89F2B150F" modified="2008-01-15" version="1">MARSRHAGVLSHSVCNASLLSSLRCFHSSTRYVSDHARVVDDLAASFADAYPSASTTSASVPASSASSSMPQYTYKRPHGVVQRAIQTILKQSPYTHAIPTMHYVTKSHLVDKLLPPALAHTNTLGGIVGLDLEWNFGLRMGKTAVAQLATANDIFVIHLSQMKRLPDTLVAMLQDPHILKSGVAVRQDLSKLQRDFGIETCGALELSRIAWKLDPERWNGRRALISLRDLCAAYLGCDLAKGPTRTSSWTQVPLTNEQITYAASDAYVSLELAHAMLLDAHAKRPMSSEDAQKLLTEVSQAKGRRVAARPRLANLASATNRVLSPIHALHCCALCIRLRKAGCVYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8X5</accession>
    <name>A8Q8X5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3362</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729327.1">
        <property type="nucleotide sequence ID" value="XM_001729275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8X5"/>
    <dbReference type="STRING" id="425265.A8Q8X5"/>
    <dbReference type="GeneID" id="5853634"/>
    <dbReference type="KEGG" id="mgl:MGL_3362"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3362"/>
    <dbReference type="InParanoid" id="A8Q8X5"/>
    <dbReference type="OMA" id="HMIKAYL"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000410">
        <property type="entry name" value="Probable PHO85-cyclin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="268" mass="30659" checksum="ADDC7F9F83496B2C" modified="2008-01-15" version="1">MKELRHTNVVRLYDVIHTESKLMLVFEFMEQDLKRYMDMHGNRGALDPVTVRSFMFQLLKGTAFCHENRVLHRDLKPQNLLINKRGELKLADFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRTYSTSIDVWSAGCIMAEMISGIPLFRGRDNNDQLMQIIRVLGTPDEHTIKRILHESPEIQYRPLPRLPKVPFQNLFPKVHPLAIDLLEKLLQFDPSQRITADDALRHPYFTTSHAVSHAYAPTSAAVDASVSDMYAKQEAKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q905</accession>
    <name>A8Q905_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3383</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729348.1">
        <property type="nucleotide sequence ID" value="XM_001729296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q905"/>
    <dbReference type="STRING" id="425265.A8Q905"/>
    <dbReference type="MEROPS" id="G05.002"/>
    <dbReference type="GeneID" id="5853655"/>
    <dbReference type="KEGG" id="mgl:MGL_3383"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3383"/>
    <dbReference type="InParanoid" id="A8Q905"/>
    <dbReference type="OMA" id="IGWICAQ"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="65"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="226" mass="25306" checksum="D409106D6DDBB10D" modified="2008-01-15" version="1">MPEPTFLTSQFFPFNPSVGVFLGRIGWICAQSLMLTSCLYIGTFFAKLLDHLSSQRESKSPEPRDTWLQCLRNYIIGPCTEELVFRSCMLTSIQHLNPHVSKATLMLTPPLYFGIAHIHHAWESLKQGGFTKRAGRLAFQSSALQFTYTSVFGWYADFLFMRTGTVWAPLTAHILCNVMGLPKFSTHRNGSPMKYIQVCAHLTGFALFIISLMPLTSTSAPGSLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q920</accession>
    <name>A8Q920_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729358.1">
        <property type="nucleotide sequence ID" value="XM_001729306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q920"/>
    <dbReference type="FunCoup" id="A8Q920">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q920"/>
    <dbReference type="GeneID" id="5853665"/>
    <dbReference type="KEGG" id="mgl:MGL_3393"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3393"/>
    <dbReference type="InParanoid" id="A8Q920"/>
    <dbReference type="OMA" id="YFYKYYK"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="106" mass="12191" checksum="BAA40B19A68918B0" modified="2008-01-15" version="1">MSDAQFQKAVEIIRNLPKNSPAKVTQAQQLKFYSLYKQATEGDCNTQRPGMLDLTGRAKWDAWNKVKGMSGEQAKKEYVDTFFEVFEPLKDDAEFAKYFEEIKNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q989</accession>
    <name>A8Q989_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729400.1">
        <property type="nucleotide sequence ID" value="XM_001729348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q989"/>
    <dbReference type="FunCoup" id="A8Q989">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q989"/>
    <dbReference type="GeneID" id="5853707"/>
    <dbReference type="KEGG" id="mgl:MGL_3435"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3435"/>
    <dbReference type="InParanoid" id="A8Q989"/>
    <dbReference type="OMA" id="FLWKTVQ"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="134"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="409" mass="44663" checksum="8ECF644203F9218F" modified="2008-01-15" version="1">MSGAITQEPAAMIQEEEKPISSHTSTQSSSLPTLSTSSPSTSSHWSDAIWNKLAALSAFRDSSSSSSKTKKQRRPSVVRRQTMSGPISGAPGFDPDASARWNHGHWSMHADQEHERDRLPIPVELKQRRYDTDPVIEPWHAARIQALFPRRLRLGKTWSLLYSLDQHGASLSTLYSRVGRLSSDMTSMTSGPSEAWLRGSSAAARSAALGTSAPAACTSLTASATNSMMDCAVVLAVRDADDNIFGAFVNEPFHVASHYYGNGQCFLWKTVQRRLPAVPEITDGDASKHDDLHPDRAIEYFRWSGENDYMVLSESDYLSVGGGDGRYGLWLDDTLTNGLSGRCPAFHNEVLCDPHESNASHAADNAPKPPADLLGPVDETQNQVESQANMSETKRFSCIGLEVWAVGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q994</accession>
    <name>A8Q994_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3438</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729403.1">
        <property type="nucleotide sequence ID" value="XM_001729351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q994"/>
    <dbReference type="FunCoup" id="A8Q994">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q994"/>
    <dbReference type="GeneID" id="5853710"/>
    <dbReference type="KEGG" id="mgl:MGL_3438"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3438"/>
    <dbReference type="InParanoid" id="A8Q994"/>
    <dbReference type="OMA" id="IREPNIN"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="563" mass="62933" checksum="2CA85FB6F588F27E" modified="2008-01-15" version="1">MVTTTNTDTVSASLPNSARSLFSPSWCTQDSTAHTGPWAWTPIIAAPAYFSYDNWLATMHAWIEHPERNSSTILRGEIWASETCSCHDVHNELDDDGDALHTTLQSRCIRRLLPRRTRLDRGMLQECAIYTCAPNHGLVVYTTLRPSDPADERPNPNFFSQATSDDLCAEAADVPYYHPAVRGVAFHYIPAHDSENLGENTSVTSQGTVRIDFALFPAEPHPISPSSRLGRTALSLLRMMHQHAYGHATSYVKRVIHDMLVPRDAYQDLYVTLRSKYAHTLIGTWAEVTDPRKHVFEDLGIAAWLILLWRDMFPACEPVSEPRHQLRCADVWGQPPGGFVDIGCGNGLLVHILTCEGYVGSGWDARARKSWHNYKQQGTVLLEARLELLHSEQLPTTAWIPAGAFLIGNHADELTPWIPFLAASTPACSGFVNIPCCAWTLEGSPFTPTNQTLSENDIASWFRVPPASLPKPSMPTAPVKAPSSSYSWTDRLAHSRWFIERTIMPSDCLSTSHKTSHSKHLAYYVYLVALHLQAGWLFESEALRIPSTKNWAMVGRYRMSEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9K2</accession>
    <name>A8Q9K2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729461.1">
        <property type="nucleotide sequence ID" value="XM_001729409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9K2"/>
    <dbReference type="GeneID" id="5853768"/>
    <dbReference type="KEGG" id="mgl:MGL_3496"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3496"/>
    <dbReference type="InParanoid" id="A8Q9K2"/>
    <dbReference type="OMA" id="RCALSEM"/>
    <dbReference type="OrthoDB" id="3337969at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="483" mass="54660" checksum="9118A87E92832780" modified="2008-01-15" version="1">MLRSHVQTTDWHRVDEALHVGVALGALNELDVYHYTLRRLRHETCTLDPHSNAAQVLSHMRQSGTKLDDSTLAQLMHTLVVPVRRAHRMQVSPDDMLSVTRPVRRILQTSFLWICGSGASRVHKDSQSDGVALHTSRTPLFRCALSEMLELELFLAYANHMAFVRHARKHQQRFLRQPDPPVHVRYTEPIRRKVAAIRLALDRDRRATIGSCERSKDDPDHSTAPFIAMDIPLVRLDITLQASHGAWAQACDELRAWVARDTSAPAVYEQRRAIVTLFSFACKHGRLCRLYEMLDILIISEQGHLWRDGESMAPGATLVRLWLRFVGAWTHGVGVRCGMQRREEVALGPYGWTLMSHALDVLMRTAMRVPVSWACVLDHPERCRALVRSAVTANGDVDVIFASLKAMKAPSRVWRWAEHALEQSSFSTTRSQRTCPNMAGHQAPTQPGHNDGDLSPVCERRNELHNHTYPHASPLIGLSEGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9L0</accession>
    <name>A8Q9L0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729465.1">
        <property type="nucleotide sequence ID" value="XM_001729413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9L0"/>
    <dbReference type="FunCoup" id="A8Q9L0">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9L0"/>
    <dbReference type="GeneID" id="5853772"/>
    <dbReference type="KEGG" id="mgl:MGL_3500"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3500"/>
    <dbReference type="InParanoid" id="A8Q9L0"/>
    <dbReference type="OMA" id="RPALMDK"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000107">
        <property type="entry name" value="Related to DJP1-DnaJ-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="448" mass="51237" checksum="DB67AFC446A0835D" modified="2008-01-15" version="1">MSEEVQPTQPANISRDGEKIADMEYYELLGVRGDATELDLKKAYRKAAIRNHPDKGGDEEKFKMIGEAYRVLSDSNERAVYDRYGKKKPTDEVGLKEATEMFGNLFGGERFVDLIGEISLIKDFGRASEIMMTDEEREEMERQMNEHLKSPTTDTVTGASDESGEANPATSASESQSQVASSSASKAERQKHKLTPEQRKKLDEFEKEKVEKEQKRITDLTEKLKDRIRPFVNARNPGAEDDNETKIFTKRMREEAEDLKLESFGVELLHTIGSVYLTKSNTWLKTKRGNFLGMPGFWNRLKERGGLIKETWNVMGSAVNVQMSMEELARRQEKGDLSEAEMQQLEQDVNGKMLLATWRGTRWEVNGVLRRVCDNVLNEKGVSDKVLMQRARALALLGSIYSEVVPDESDEERRELERLVARAAQKKKKHKDSSSRRGFLRLHHHDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9N1</accession>
    <name>A8Q9N1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729479.1">
        <property type="nucleotide sequence ID" value="XM_001729427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9N1"/>
    <dbReference type="FunCoup" id="A8Q9N1">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9N1"/>
    <dbReference type="GeneID" id="5853786"/>
    <dbReference type="KEGG" id="mgl:MGL_3514"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3514"/>
    <dbReference type="InParanoid" id="A8Q9N1"/>
    <dbReference type="OMA" id="DWIAAAH"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="36140" checksum="B3B00F282899EAD4" modified="2008-01-15" version="1">MKRCETQYPFVVMVTPTVDTNTRQVLQQMGCIVRDVDVWHVDRPHEIMATERFIHVWTKLRAFELYEYDRVIMIDSDMLMCQQMDELFELELPPDTIASGLACTCNPNAIPTYPPDWTPENCGYALRPHPPPRSVRKRSTHHLMNSGTVVLRPSMRHSEAIHGFMREHAERIAQYRFPDQDLLADMYREHWVVLPWYYNALKTLRRCHRDLWNDRHVRMIHYILDKPWQTGPQSAARDDPDAHLHSTWWSTYRSLAADPTRVGLTRERWTCDIAVHVNDSTPSRNVVADKARTLEENNMAFMGIQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA62</accession>
    <name>A8QA62_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729154.1">
        <property type="nucleotide sequence ID" value="XM_001729102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA62"/>
    <dbReference type="STRING" id="425265.A8QA62"/>
    <dbReference type="GeneID" id="5853460"/>
    <dbReference type="KEGG" id="mgl:MGL_3621"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3621"/>
    <dbReference type="InParanoid" id="A8QA62"/>
    <dbReference type="OMA" id="HAWASEW"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="630" mass="69954" checksum="79A04C98F3824F87" modified="2008-01-15" version="1">MTLSWSMDQVLVANRISAELHELAKRGDKEACISYLVNELRSYGLNAHTQAYAYYVPGSDEPLRGVNIYARSHTPQIDGREALLLAASWRSHWQGNATSDEMELPFVPDDGQRRAINVRGISLLLALAKHTSSIPFWSKDLMFVISDGFLDGMQAWATQYFGLEQPNLDAEPILCTGAQIWNALALDYPADSFSSFAFLFEGRDGLLPNLDTVNTISNIARSDLLSPAVELHGLSTKGPLRFLRANALPSWVPVAWIERKWLGYNGVDRFLVGWRNILAQLRLQLAGHPSGIHGVLLPFHVDGVTIFGEPASGPYGFIELGRISESTMRSFSNLLERLHHSQFFYLLASPWRFVQIGVFLFVPLFLAAALTLKGIAVWSQLGSLRQKQRNALRRQYTKSVPLLAEPTYDEFAQLCNDEEQRARFRSYDRPVIMVLLLMGVCHGIGGVILALLSRTPIDCAAALGLGSCRPLLWILLCSLLSPVIMACYARFWKGATLLSLAMCLHAFTLLNAGMVISVLATLNFAQATTMALLLCATLYPVCVLHDRSFFRSAWYLLQGISLVLVSPPILTIAATFLPRAWLSGLDVEHILRAALWDFHVLRTSMLHILCLGYAPMILQGATACLLYSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA68</accession>
    <name>A8QA68_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729160.1">
        <property type="nucleotide sequence ID" value="XM_001729108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA68"/>
    <dbReference type="FunCoup" id="A8QA68">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA68"/>
    <dbReference type="GeneID" id="5853466"/>
    <dbReference type="KEGG" id="mgl:MGL_3627"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3627"/>
    <dbReference type="InParanoid" id="A8QA68"/>
    <dbReference type="OMA" id="ELTSHAC"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="159" mass="16163" checksum="F20784907F0E0966" modified="2008-01-15" version="1">MPKAIVFLAQGAEEMEFSITYDVLVRGGVDVTSVYVPGADEPLSPADGLVVASRGVKLGVDTTLEALTKSGHAGDYDAYIIPGGAGGANTLSKDPTVLQILRDSHANGKIVGMICAGSLAALEARVGLGGPITSHPSVKDKLASCTYAHGLDGSSNLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA84</accession>
    <name>A8QA84_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729176.1">
        <property type="nucleotide sequence ID" value="XM_001729124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA84"/>
    <dbReference type="FunCoup" id="A8QA84">
        <property type="interactions" value="688"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA84"/>
    <dbReference type="GeneID" id="5853482"/>
    <dbReference type="KEGG" id="mgl:MGL_3643"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3643"/>
    <dbReference type="InParanoid" id="A8QA84"/>
    <dbReference type="OMA" id="DETEMAR"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated" evidence="6">
        <location>
            <begin position="411"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="519"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated zinc finger" evidence="7">
        <location>
            <begin position="745"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="88227" checksum="BF8473CE48678E62" modified="2008-01-15" version="1">MLAVACKRCVVLYRWVDGAFWDCKVHSLPRTPKTLALFQGTSLFAGYAQYEYVRVAIRPAHASSVAWRTPPSDALTSGTWTDTAGWDTYAVPLPTSAAQESNWWSRSWRPLVLALEHDVLVSTMRQGVFVDAYGRPSRKDVLEWDAPPLHGTTAAPYLVLHESDGTLGVYMQTTLRRAQSVKLPSEAGAVRFIAAGPQLGVVVCTSACVAMPNEVTVGAKMIASSSRSSGSLYALEPSPVNDQLAALTSSGNYHEALALLDALDPALWPHDIHNQRLHIQALVGLASFVNGKFDVAVDLFIDTHMNPTYVLALYPETISGPHAQPPSSWATLFDAQIPWDHAVDETKRTSSEALDALARYLSDCRRVLRPKTAHLKHTVCVDTHCIADLPMCACTLDKMNEKQLMAMAQVVDTALFHVFLQTKPALLGPMCRVDNWCDVERVRPHLEQRHMFDALVSLYRSKQMHAAALELLQSQREYFVDPIKSTIDYLEALGPEHLDLILLHAHWVLDMDPEQGMCIFTSESHLESLPPERIAHDLASFRPPLCLTYLECVMEVRRVDPSLHTLRACLYLDACRGGASHAALLEFLCKSTLYDVDAVLHRLPDEPAWPEVRAVLLGRLGRHDEALRLYLVELRDIARAEAYCVTYARDTERGTLLSKLLRIARTYSPQHLHHVYAILTQHAQDLNLGEVLALLPQNLPVQHVYGLLERALQAQTMERSNVRVIRALCEAQVSALDQDLRALQQRHVLVTEGRTCVRCHRRLGQAVLAVMPATGATMHYYCAMDDARGKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAA7</accession>
    <name>A8QAA7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729199.1">
        <property type="nucleotide sequence ID" value="XM_001729147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAA7"/>
    <dbReference type="STRING" id="425265.A8QAA7"/>
    <dbReference type="GeneID" id="5853505"/>
    <dbReference type="KEGG" id="mgl:MGL_3666"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3666"/>
    <dbReference type="InParanoid" id="A8QAA7"/>
    <dbReference type="OMA" id="VARAYTM"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="752"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1181" mass="127295" checksum="4647498222AF4CC4" modified="2008-01-15" version="1">MRGEAAASSETAETNSPPVALAGAGTSPVGASTRLDAIAKLRRAASQREIQQSSSPSRTPSLPSIQQIDDSVKRVDEPHYKPPIAQFQLPSLEQLRQRIIQERRPTGLSRSASTSATSQVARAYTMQKLLGATTPISYADMFAFVRDTNKSRGEIDTVTSDEDVSAHAVPDTSVPGAGVSLLKPRRATLMRSVSARNNARMHLYRRHGRTPQENALAPGAITPIQGSPPMQGSGELAASDDGSTVAHDSNSTSSWRVSLYDYDSTSPIVSPPCGLAPISSAPIVPRAVDGVAALPPVGQGGVLLPGERWLRETSVATAPHQQPAASDENAGTRKTSEAEEAREVREANETRKAKEAKEAEPVREASEARRADKAANAPHAPYAPDLATPPSTLAAPKLTRVTSHTAQLDTQVPRSGKISEKKAEPMQGVSVTPSPSTPTIPAAANLPAVSIPWGDPSPEAPAAHVISSVPSSRVATPVCMSPSLSHDDGGQKPLPRLPSSAQLPPVPPLPEPRGEHRLGDSLYGAQLRQSPTPSLEALPTVPKPLLHTRSFSAGGSSSSSSGGFPREDVAADDPKKEARVMRLFGSLRRKTSRRALGSLRRQAKVPSTDPSHVAMASIVLLGESGESVLHDKVVTLPVTPAALMRWNQTLPRPLRHVLARLPAEMPLDLAMDPPRQLLRVLPLLQTAGDEYVKLRYVFVFQDMMVVAKPVVLPRQGESLSDFIIRKLASVPDLSESCTPFAVLDLHHTCIDEGSSLVERTAKLDALVRQRITHLHVNPTKTLHQLMNDARLRGPESRAYAQLLHSCTALDAGFVSDFLFANHAVLEQYVAQHCVAGAPLELALRALLASLRWPRDMPTFEVLLFAFAAHWHAANASEHAGLTLELTTDLTFALLGLNDALHDATGLFARPNPALSVDKFVMLFRVHDTQKTISDRLLSEVYLAIKTSPLTPAVSRDAWRAVSFDADALCAEPLKPGVPSAPVRVSLDAPDSDVRIRLVGRGLYIDPPVLSFTHAAHAEFSVCATTPGSYDLLFLRTGRHAARYMNQQHQPMQSPLPRHLPLVCETSTARPTIKLVHMPPGSPRTDLTFCMTDPHSAEQVASFLRASMETAHADALRLTQAELDVRTLCRLVLESALLAPDSNDTRRRACRSSTGTQIVRTARENSLLAYVLLSTELRRVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAN2</accession>
    <name>A8QAN2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729003.1">
        <property type="nucleotide sequence ID" value="XM_001728951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAN2"/>
    <dbReference type="FunCoup" id="A8QAN2">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAN2"/>
    <dbReference type="GeneID" id="5853310"/>
    <dbReference type="KEGG" id="mgl:MGL_3791"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3791"/>
    <dbReference type="InParanoid" id="A8QAN2"/>
    <dbReference type="OMA" id="IPNWQLC"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1053"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="SPT23/MGA2-like DNA-binding" evidence="7">
        <location>
            <begin position="165"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="522"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="739"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="772"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="837"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="845"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1096" mass="120987" checksum="3B290163E56D14C9" modified="2008-01-15" version="1">MSSMYLPSAMDEQMIMSSNALDSVFSPATIDSFDPAHDKYQTHGNISMDADLPSQASVNEEPLSAGVVNSAASSSRLPDTDSSSGVCISPNTNFKPSVSMTGLPFATTDVNSIAPALMENAVGDSKVPAMSPAQVPLSNAANDASLTLTSIRTIWPSRSNLPSDMKILVNGVPAIGAKSRVETQIRMRIELVHPIPTDNPQVAPQYERIGSFTHIKVPPLSGTKRKSKKHQKLHVPLESTLVLDAEVINATPPHSRVYVCNSCRERERKRAHRKKSKVSLQTINPTEEEMSAIGIDPKSPDAVERAVSYLEEEERKHAVLFNCGDYVDFHDGEVVLSTRITCYCRHHREKIGFHIIFTLRNHKGEFIATGSTPPIMIMDDHKSVSQATTVSRLNESRLRSNAQDRAFSPSRTIETPSRMRDRPKPYDDSSRYRRSLPRETSQPPLLQDSSRMSFPVSESIGASWLRSVSPVSLDESMPNSSMTLHEAALSSPVQMSGLPPFPPLPRLSEDHRSEASVSLSIPRITKLVPVEGPTTGGIEITVLGENFRNGIQCVFGDMPSTFTRVWAPTTLVCILPPSFRPGPVIVRLQDPTPPQALLEPGGSHPLQLFTYIDSTDRALMELALQVVGIQMTGQFTSARDIAMRIVSASQGNEASSSRGMASQGNGVGNGMCNKLSSGSGVPDVSDVLSSGLRLNSTRSSKLPGVQDSLLGFLTLLDVDMNSSSDKPFQRNAIHACNSSGHTLLHLAVIHNFHRLVSDLLHRGCPVNARDANGYTALHFAALHGWMEVTKLLLLHGANPYDINEEGLIPLEVARRSEKIDVERMLIEWVDYDDNESLDAEVGNDTSDEEITMSDADQELDYYVDDETETETDDEAEDADEQNRGKREEHDTSESEEWVSFGDLASIDRVSCTSSAPGLPTEREPRIPASPDQPHPRRPSNLLQALPPWDHEVKLPGPIHSPPPTYDEATTTFKGEPSSSKHIDGEKLITSPDSLTLSRTQHPMTLANEREFAYIRKERRSNRMARHRRSNERSKETATETVVRPRQGVYDDRMLLWFWIPAMLLALLVPFVLQTRTFASFYEGSWLQRITQLTSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAP0</accession>
    <name>A8QAP0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729011.1">
        <property type="nucleotide sequence ID" value="XM_001728959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAP0"/>
    <dbReference type="STRING" id="425265.A8QAP0"/>
    <dbReference type="GeneID" id="5853318"/>
    <dbReference type="KEGG" id="mgl:MGL_3799"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3799"/>
    <dbReference type="InParanoid" id="A8QAP0"/>
    <dbReference type="OMA" id="EEGLRWW"/>
    <dbReference type="OrthoDB" id="2357318at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="760" mass="83613" checksum="3838AE4F2B582A7A" modified="2008-01-15" version="1">MAATNDAAYQSLRRLLLASPVNQSHIDLLDRNALYGSIGHFLSSMSLLNVTDFSEALIRSPALWNAPAFSDVNASTQQAVERATGIAQALSFAVSERVTIISKALRRAAPRSAPAELGAWLQAILEGVHRVDHDVHHPHHTRGKAVPTTPTASMSRAQAPPHPSSSVPRTYLAKLATVTGLVHGVLSERNKRTRFSLWFHLGRHTRTLEHAWAAVLADALQKNSYWDVASRTASLTLAASVVDMVSEASMRTVSDKTWIEAAMPLVLDVFDVERATSTGLFCDASPDARGIVSLPAHGTSDAWRSRVQSHPLYAHAGPLARLLASAIRRLGAATSPQEFIAYLWGHQDDAEAQAPFPPMASSNSDASDPGRSYGMLRRWFTGSMQLDDAWTSSALAGLETAHIEPASRERTTQIWQVFKTYLFTLTLVLDAVVGIIVEQCPSPTETYPPATDKSECERTNGEWPAMPTSNVPEPYLDALAHVLRIFERVYWITSTFGLDGFESYRVVFYSALDVLSRDASACTQVVSSMAHDLLQRHKDVPGGRPAAHVSFAQRMHVTYFLLVMEQWVAELPHAMLEQLGLPMCRPYLEDTRFQDAFESAHSVVLALYACGAPCTRELTPFYVDLLLTCFPKQQLSASQLEVALMTIVQSLSDRSDSLAWWCIARVDDQVSIAQLQGRHDVAETLAVCLAAMVPHVNLILLRALLSKVDTRIREQPAGSPARARLVERVFESLGDMDAATRPEALLWWLDKSPLLTQGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAQ0</accession>
    <name>A8QAQ0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MGL_3807</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729019.1">
        <property type="nucleotide sequence ID" value="XM_001728967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAQ0"/>
    <dbReference type="FunCoup" id="A8QAQ0">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAQ0"/>
    <dbReference type="GeneID" id="5853326"/>
    <dbReference type="KEGG" id="mgl:MGL_3807"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3807"/>
    <dbReference type="InParanoid" id="A8QAQ0"/>
    <dbReference type="OMA" id="TWYAIGT"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="21">
        <location>
            <begin position="17"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="22">
        <location>
            <begin position="517"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EDP41805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="721" mass="81121" checksum="6AA5D203EF283D7D" modified="2008-01-15" version="1">MAWNSTLETKRNVASLLRTVILIMVAAAAVSSRLFAVVRYESIIHEFDPWFNFRATKVLTKDGYYRFWNWFDPTAWYPLGRAAGGTVFPGLMVTSGTLYNILHFFNIPVNIRDICVMLAPIFSVLTVLAAYLFTSVMKDDSAGLLAALFISIAPGYISRSVAGSYDNEAIAIFLLLFTFYLWVRAVRDGSMLFGTLTALFYFYMVAAWGGYVFITNMIPLHAFVLVLMGRFSERLYVAYSSFYAIGTLASMQIPFVGFQPVRTSEHMAALGVFGLLQLIALTELVRKYVSSQQFKVLVRTFVAVTALAAFAALVMLTYAGYIAPWTGRFYSLWDTAYAKKHIPIIASVSEHQPPAWPTYFLDLHCLVYLFPAGLFFLFHHLRDEHIFVVIYAVMASYFSGVMVRLILTLTPCVCVCAALATSALIDVYAGSPVGSEASRKNGRSVRTMPLEARMLVLGCVGIVLEMFILHSTLITSSAYSSPSVVLASQTPDGNQVIIDDFREAYYWLRENTPQDAKVMSWWDYGYQIAGFADRTTLVDNNTWNNTHIATVGKAMASSEERAYPILRKHDVDYVLIIFGGLLGYSGDDLNKFLWMIRISQGLWPDEIQEHKFFSNGEYRVDDKASATMRNCLMYKMSYHRYNDLFGGQAGMDRARNAMGPSTSPTLDTLDEVFTSENWLVRIYQVKKEDTLGRHLPLAHAFEQGKRLHQAPFPLNADAIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB72</accession>
    <name>A8QB72_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728893.1">
        <property type="nucleotide sequence ID" value="XM_001728841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB72"/>
    <dbReference type="GeneID" id="5853286"/>
    <dbReference type="KEGG" id="mgl:MGL_3887"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3887"/>
    <dbReference type="InParanoid" id="A8QB72"/>
    <dbReference type="OMA" id="SANDAFH"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728156" description="SSD domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="10">
        <location>
            <begin position="305"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="695" mass="77166" checksum="CB94354BC41B6DE8" modified="2008-01-15" version="1">MVLLCNLVIASLFYPAVVIYLLTTSDDPDSSMNAPVCVLRDRIHPGMEPPCVTGAWTPTNIWDMAKASLQDLTGSVRAHALSDDYPVHDLRLLWDETPTLAVVSNEQREMPAVVHVAQVLLSSDAIRHGGGAPYGVLHPQFLLMALQLQNELDKRLTSDSQTPGPSCIRRNETNECLVLSPLEFWHRDEQVLLADPHPAKSYTGSPVRAVVTPPVAPTVMQSPLPLLYSTTLSGRWPFLPLFSRAEYLVLTYFLHETNMHAWPDVVRDAVDHVVPAHVLMPQNITAGSTTLQFKPESLRARPTLDYKIVIAGYLLLLTFIFRGLVQMRRLHSRFGIAFTGSAQLVMDLIMSRSLCALLGIHLTAVPWPILPFVVVVVGSETMLFMIRVVTNTPLSLTVNSRVAYGLSQVAGPITLSTATDVLLLLLLSSLLRIEAVTQFVLFTICALVVDYFMQMTFFITVLSIDIQRLELAEVLLQGTRAPSTAVTPHPDLPHEPVLYGPRAGAAHFFSLLYHLWRIRTARGISVAITILAACAALVAYGPKLVSSNAVQHVLHERTISQMPMDAELDKSPYGAFWRAINPTGESFVRMVLEPWTLVTTTGPNWYAASVAGDVPGPWLEHLFFDRRSTTVFLFFLFVIAPIALSMVILSMILNYLLLHSDKLEASAHHDSENIELRRLLEPTWSRPHQIPCRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBC7</accession>
    <name>A8QBC7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728906.1">
        <property type="nucleotide sequence ID" value="XM_001728854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBC7"/>
    <dbReference type="STRING" id="425265.A8QBC7"/>
    <dbReference type="GeneID" id="5853212"/>
    <dbReference type="KEGG" id="mgl:MGL_3900"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3900"/>
    <dbReference type="InParanoid" id="A8QBC7"/>
    <dbReference type="OMA" id="YDIPANW"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="208" mass="23317" checksum="CAB296FC33A78D1D" modified="2008-01-15" version="1">MASTTATKEFLQVIQNRRTIYALSKKTILPDDVLIKYIQELVREAPSSFNVMSSRCVVLLGAHHDKYWGELVPGALVSIVGEEGLAAMRPKLEAFRQGYGTILFFEDQQLIKAQQEQYPTYAPSFPIWSLHSSGMAQIYVWSGLEAAGYGASLQHYGNLTSDALKQQYKLPASYQIQSEMVFGYPEQGAQEKTYNPDHERVIAYGHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCF8</accession>
    <name>A8QCF8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_4004</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728837.1">
        <property type="nucleotide sequence ID" value="XM_001728785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCF8"/>
    <dbReference type="FunCoup" id="A8QCF8">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCF8"/>
    <dbReference type="GeneID" id="5853143"/>
    <dbReference type="KEGG" id="mgl:MGL_4004"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4004"/>
    <dbReference type="InParanoid" id="A8QCF8"/>
    <dbReference type="OMA" id="QLVHMRI"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="407"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="185"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="712"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="624"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="499"/>
            <end position="505"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="763" mass="85192" checksum="34BE3D85DBC40317" modified="2008-01-15" version="1">MGRRAKNKQPAPAPLPDPQQPQKKQLGKRKHGKDVKNGKEAASIVESKATRETSAPMTSTKRMESQSNLLAKKQRIQEVKKQQRNRTSEPAYEDKDKNKLATHDESDKDDVDYEEGMLEDKEKEKGSVEGERELRRGVQYKSGKSRGGEISADQVLESLGLPKNKKLTERQKKKVLAEVERLELLLKSSGYSVDESEDDGGEAHDRELGVGNVEHEIDEDSGTEDDDDVEGLDGGKDVGDEVDADEGGDDDDSGEAIEDDFSGIEDMDDDDEVEDEVDVGDDHVDLESIDEDDADDIEGHAAEEEDKFDEEEDAGDDGEQVASNFLLPTVEDEEEEKRAPLDLQLVHMRIQEVVNILSNLQTLSEPGKSRADYMDRLSKDVQTYYGYNEFLTNMFLELFSPDEAIAFFEANEVPRPVTIRTNTLRTRRRDLAQKLINRGVSLEPVGPWSKVGLQVFESSVPIGATPEYLVGEYMLQAVSSFLPCMALAPQPHERILDMASAPGGKVTYLSALMQNTGCVFANDSNKARIKSLTANIHRMGCRNVVVCNYDGRQFPKVIGGFDRVMLDSPCSGTGVISKDASVKTNKTKRDFILLSQLQKQLILCAIDSVNPRSESGGYVVYSTCSVMVEENEEVVEYALRKRPNVRIVPTGIDFGRDGLKCFRGKKFDERMPFCRRIFPHVHNMDGFFVCKLKIDPVNKGEKRRLEAEAVAVDQAAESKEPPLRMPASSAKSSIEPETSVFDAEEDDAIMQRSRERMAKKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD17</accession>
    <name>A8QD17_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728750.1">
        <property type="nucleotide sequence ID" value="XM_001728698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD17"/>
    <dbReference type="FunCoup" id="A8QD17">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD17"/>
    <dbReference type="GeneID" id="5853063"/>
    <dbReference type="KEGG" id="mgl:MGL_4085"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4085"/>
    <dbReference type="InParanoid" id="A8QD17"/>
    <dbReference type="OMA" id="EYYRIDV"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="351" mass="38498" checksum="EB6F45C7BA1A9C4C" modified="2008-01-15" version="1">MTALRLLPSKLLRSAAAPATRMPIAASARSFSQSVSAFKIKHWDAPNRHKVSPDEMPINPGPNPDPKNIGVNAVLNLRPESLNRHTTSIFAEFSLEGKTAVVTGGNRGLGLEMALAFVEAGAHVYVIDQAPEPCEDFKRVAEHCHMLNRQIEFITADVTNADQMNEAMRYIEKDSRTRSLDICVANAGIMQTHPAIDYPADEFRKVMEVNTTGVFITAQAAARVMRQRPELTGSIILTASMSGTVVNRDQEWTAYNTSKSAVLQLGRNLAAEWGPYGIRVNTLSPGYFRTNLVADQLDSNPELLQRWSEANPMGRIGYPHELRGVVVWLASNASSFCNGADIIVSGGHTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD39</accession>
    <name>A8QD39_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_4107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728772.1">
        <property type="nucleotide sequence ID" value="XM_001728720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD39"/>
    <dbReference type="FunCoup" id="A8QD39">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD39"/>
    <dbReference type="GeneID" id="5853101"/>
    <dbReference type="KEGG" id="mgl:MGL_4107"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4107"/>
    <dbReference type="InParanoid" id="A8QD39"/>
    <dbReference type="OMA" id="LCGWVDR"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04317">
        <property type="entry name" value="EcAspRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047089">
        <property type="entry name" value="Asp-tRNA-ligase_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="209"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="715" mass="78813" checksum="7886E4E948811C09" modified="2008-01-15" version="1">MWRRSTAWLRCHPRVTLSSTSQWTVACVDHRCVSGTPACQRHLSLTPWRSTSSRPVASWPTVPRTHACSQVGSNDVNERVVLAGWVLAPRKISRQLAFVPLQDASGTVQLVLHDPALVDAFAQVPVESVVSVQGAVQARAEGAINPAMRTGAVEVRVESWTLLNAATPTLPFYATQCREPASLPKESLRAKHRYLDLRRSSLSENIRRRSRVAHAARCFLHDHAFTEIETPILLRSTPEGAREFLVPTRSAPEPQFYALQQSPQQPKQLLMVSGVTDRYFQFAKCFRDEDGRKDRQPEFTQLDMEMSFVCGHGDQPAWPLGGTEIRDVTEGLVRSMWTAAAQPYALPNPFPIMSYEHAMTTYGSDKPDTRFGLRIANLIPTCTSHALDILVLPQYESCKLSGRAKEALLLDQHGHRCAIEHFKAHRSAPDKLAHLLLTKSRHVHDVMHSGKLGPADRALDVSSLTHTLQDVLRDATAFRCDGASAHAHGDSDDRCDVYLATRSLPIDGGSTPMGDLRLRIADALPIRSAEPAVLWITQFPLFTRADADKAEAAHGRWSSSHHPFTAPLASDVQRLYESVACRAPADRDAILAQIHGQHYDLVLNGAEIGGGSVRVHDPDLQRMIFRDILELSDDEVGRFSHLLHALESGAPPHAGIALGFDRFMAILCDTLSIRDVMAFPKTGSGTDPLFSSPAALDAPEQRAQLAAYSLQARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD48</accession>
    <name>A8QD48_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_4116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728781.1">
        <property type="nucleotide sequence ID" value="XM_001728729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD48"/>
    <dbReference type="FunCoup" id="A8QD48">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD48"/>
    <dbReference type="GeneID" id="5853044"/>
    <dbReference type="KEGG" id="mgl:MGL_4116"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4116"/>
    <dbReference type="InParanoid" id="A8QD48"/>
    <dbReference type="OMA" id="YIATFFP"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="180" mass="20385" checksum="CA0CD045C52BF6CE" modified="2008-01-15" version="1">MARGAQKRVSQANQRAVATLAYGFLVSNTLFVLAACLRRQTSPWRTWTLYGITEFLAALIAWKLVAMAQVGDDLSLPGMTAYMFDFVYITWFVHVGVALVSRRLWWTYAVIPMYLSYLFYKNVFVPYILPRLRPARHVPQGGYRGTAPSEDKGTSVSKRQAKMQARQARGGGLRVQTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD77</accession>
    <name>A8QD77_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prephenate/arogenate dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728666.1">
        <property type="nucleotide sequence ID" value="XM_001728614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD77"/>
    <dbReference type="FunCoup" id="A8QD77">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD77"/>
    <dbReference type="GeneID" id="5852990"/>
    <dbReference type="KEGG" id="mgl:MGL_4145"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4145"/>
    <dbReference type="InParanoid" id="A8QD77"/>
    <dbReference type="OMA" id="RRRFEMT"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="471" mass="52725" checksum="A99D8AE37255FEDB" modified="2008-01-15" version="1">MYVIVTWQTTFVASAEKEKPQRQLSLGIIGMGDMGRLYTTRPRAAGWAHVNVCDRPEKYESLRDEFQGTELTVLRDGHLVSLQCDFVVYSLEAGNIQKVVAEYGSSTKVGAVVSEQTSVKAPERDAFEKYLPQDVHIISCHSLHGPHVDPRGQPLILIQHRAPADKPHLVERILACLESRYVYMSYEEHDTVTANTQAVTHAAFLTMGTAWAQLQAYPWVTGKNPGGMETVKIYLCLRIYGAKWHVFAGLALLNPEASVQVTQYAASATALFQLMLEGKYDALVQRVLSARRSVFGWQDTEVGTNLPGRSRILVSDEMLDEFYVIAERVNKGEKSAAEAERTVREEAPPANSHLSLLAIVDCWHVLGIDPYRHLELAATPVFRMWIGVTQNLFRSPDSVLAACRAAVDDVRFRADDLEFVIAARGWAQAVQFGDFDAYRRRFEMTRAFFAPRLTEANKVGAEMLRVLSTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDR0</accession>
    <name>A8QDR0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45228"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45900"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="ChEBI" id="CHEBI:85489"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000023">
        <property type="protein sequence ID" value="EDP41416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728630.1">
        <property type="nucleotide sequence ID" value="XM_001728578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDR0"/>
    <dbReference type="STRING" id="425265.A8QDR0"/>
    <dbReference type="GeneID" id="5852941"/>
    <dbReference type="KEGG" id="mgl:MGL_4229"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4229"/>
    <dbReference type="InParanoid" id="A8QDR0"/>
    <dbReference type="OMA" id="LWIIELH"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000049">
        <property type="entry name" value="Enoyl-CoA delta isomerase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28874" checksum="4E213532631A51F6" modified="2008-01-15" version="1">MSTETSVYKAREGDIPLLRSEFHVEKRIWVLTLMGQQTPDNRLTHSFIQEGMIPALRDIRAQWNAWVEQDEAEMGAALVTTAELSSKIFSNGLDLFNAIADPHFFNDYLNAMFTELLTFPIPTIAAVTGHAFAGGCTLALAHDYRVMNSKRGYICMNEIEFGAHIPQGMLGAIKSVVKTSQTMRKLVLEGHRFTGEEALKDGLVDATADSAEATLRVAMDMADKLRSRCAKNGWQVNKELIHRESLAMQFEPPRVSAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8QE25</accession>
    <name>A8QE25_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000025">
        <property type="protein sequence ID" value="EDP41396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728610.1">
        <property type="nucleotide sequence ID" value="XM_001728558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QE25"/>
    <dbReference type="FunCoup" id="A8QE25">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QE25"/>
    <dbReference type="GeneID" id="5852920"/>
    <dbReference type="KEGG" id="mgl:MGL_4251"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4251"/>
    <dbReference type="InParanoid" id="A8QE25"/>
    <dbReference type="OMA" id="SKSWHSY"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="51912" checksum="5FBE8B79F5D50601" modified="2008-01-15" version="1">MPGIYGGDEINAVVLDPGASVIRGGWAGEDQPRAMLPSFYGWLPMTDEERNLYGTEGLKQDPGPTQDGDVSMNDVENHSKPPVPRGISFDASRGRKRFLGDSGVSYWRRGLEIDTPFDENGIVQDFDSLHAMSRNVFDALCAEPTENPLLLTEPADNPRAARGKAAELAFEGLNVPAFYLANRTVLSAFSSGRPTALVVDVGASRVSAIPVVDGFVLRKGIHTQPNGGDAVSRALLWGLTHEMGDKNITGWLADSIVPQFLVKSKQPCDPGMPAKATLREDRLHSTTPSFRMYHTMQVLNDFKEAVCQVLEAPWDEAQASARPTKMFEFPDGSNDAYGMLRFKAPEALFTPSLYSVDSQVLPSRESPYTGLTDLILQATKEVDVDARASMFSNIVCVGGGTLLPGFLDRLSYELSVAAPSQRIRIHSPGNYTERRHSTWLGGSILASLGTFHQLWISKQEYEEHGQAIVHVRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8QEI2</accession>
    <name>A8QEI2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000035">
        <property type="protein sequence ID" value="EDP41376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728590.1">
        <property type="nucleotide sequence ID" value="XM_001728538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QEI2"/>
    <dbReference type="GeneID" id="5852898"/>
    <dbReference type="KEGG" id="mgl:MGL_4269"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4269"/>
    <dbReference type="InParanoid" id="A8QEI2"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728179" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27853" checksum="AE42A4735E1140A6" modified="2008-01-15" version="1">MKFDTTALIATWLLGVAQAAPAHEKGELDCHPVGEAGIIASQDHWTNHYYGHLHYDFKESRLEPTEERKGKPKKKLQFYECKPPTSKLNGTTAQHWFGQLRVADEPSKCVTTTTWWVKTKDTGPYGGPGYTSRPEGKKTETTLKECSTSEETLRLQWFGMTRPSKKNVNAALVHKGYAEDEEAFAICGNEENTDEGKGSYFCRASDMRSNGFAMSMLETKEEKRGESGEDPPAPEWYLGKEDMKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRC5</accession>
    <name>A8PRC5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732246.1">
        <property type="nucleotide sequence ID" value="XM_001732194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRC5"/>
    <dbReference type="GeneID" id="5856552"/>
    <dbReference type="KEGG" id="mgl:MGL_0021"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0021"/>
    <dbReference type="InParanoid" id="A8PRC5"/>
    <dbReference type="OrthoDB" id="3366529at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="212" mass="24086" checksum="BF1D1563D35C2707" modified="2008-01-15" version="1">MPTKALSSRLQGLKFMQRGAQREAEQAEADKADASSRTRFNSERHDDDEDVDPSPTTATDSSMSEQWVVPSYFRVKPRNSVQEPEQWESWFLNATAEDQTPTRQQFGAWKEEIHRPKAQRSENHLDPAYSDDATDDEEFSDNEEDQDMDESINRRVSETFRKSQDFRKPPSASNGPKTGTKRRASGAIPPKQPKIAAVADKSKGLRKKKESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRR8</accession>
    <name>A8PRR8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732338.1">
        <property type="nucleotide sequence ID" value="XM_001732286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRR8"/>
    <dbReference type="FunCoup" id="A8PRR8">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRR8"/>
    <dbReference type="GeneID" id="5856644"/>
    <dbReference type="KEGG" id="mgl:MGL_0113"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0113"/>
    <dbReference type="InParanoid" id="A8PRR8"/>
    <dbReference type="OMA" id="LERYQHH"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="169"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="324" mass="36712" checksum="5C657644595B59B3" modified="2008-01-15" version="1">MSRAWTPQSFFAGFPEPEGLHERTRQVEAFLHRHGANGRKVVLVTSGGTTVPLEKNVVRFLDNFSAGTRGAASAEYFLKHGYAVIFMSRQHSQFPFTRSYSHTTNPLFDLLEEPGANGGSVRVCEDQVGRLLPILHAYHDAKKHGLLLTVPFVTVIEYLFLLRNISLAMASIGRQAMLYLAAAVSDFFMPEDRISEHKIQSSDHALTIELEQVPKVLGVLVQEWLPEAYIVSFKLETDDNLLVPKSERSLRNYGHQLVIGNHLHRRKWEVVLVEQTARMRTKTTDTTQPFEHTWIRLPPGSEREIEQDIVLALAQRHIGWIGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRW0</accession>
    <name>A8PRW0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">imidazole glycerol-phosphate synthase</fullName>
            <ecNumber evidence="2">4.3.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732365.1">
        <property type="nucleotide sequence ID" value="XM_001732313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRW0"/>
    <dbReference type="FunCoup" id="A8PRW0">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRW0"/>
    <dbReference type="GeneID" id="5856671"/>
    <dbReference type="KEGG" id="mgl:MGL_0140"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0140"/>
    <dbReference type="InParanoid" id="A8PRW0"/>
    <dbReference type="OMA" id="GNYGHFV"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="576" mass="61952" checksum="2DC3023AA5DC8B51" modified="2008-01-15" version="1">MEALHAKGYVEPLRTYIASGKPIMGICVGMQVLFQGSDESPGVLGLGVVPARVGSFLPEDAHGRKAVPHMGWSLASVVDVKDESIDSKSRGSESTSSRQQLGTSYGLPVTEPAHFYFVHSFRVAYDESIAPWTLTTTQYGSETFVSSIQHGNVFATQFHPEKSGQAGLNLLAAWLHLDDAALHATKDARIRRPMATHERMPTRRIVACLDVRSNDDGDLVVTKGESYNVRERQPAEGQAKSTADGTIRSGGKAQVRNMGKPVELAQRYYEEGADEIAFLNITSFRNWALGDQPMLSLLNVAAATIFVPLTVGGGIRDFTDPDGTFHPALEVAHAYFRAGADKVSIGSEAVYAVEQLLQRATELGDCTGDPCAAPAMALRGDTGIEQIAHKYGVQAVVVSVDPKRVYLSDQEIDGLSDEHSSGDGPVDARTHPHASSIVCGQDERPETAGQSARWWYMCTVKGGRESRDIDVVQLARGVERLGAGELLINSIDRDGSYAGFDEKLIDLVRGCVNIPVIASSGAGCADHFCDVLASRPAARGAPIEAALAAGIFHRREVSIMDVKKRCADAGYPVRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRW2</accession>
    <name>A8PRW2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732366.1">
        <property type="nucleotide sequence ID" value="XM_001732314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRW2"/>
    <dbReference type="STRING" id="425265.A8PRW2"/>
    <dbReference type="GeneID" id="5856672"/>
    <dbReference type="KEGG" id="mgl:MGL_0141"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0141"/>
    <dbReference type="InParanoid" id="A8PRW2"/>
    <dbReference type="OMA" id="AYRQVYA"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="1">
        <location>
            <begin position="113"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="459" mass="52299" checksum="42CD3D6848763576" modified="2008-01-15" version="1">MPARPIPFVTWPDPRLSAYRQSKFVATNETAASSSASSSRAAPLDDPNHFSFASISCVKPDFPYEPAQFWGWNWLLRWMGIGTEPGGRTLRNRIRGFDIMADHVLRGAGQAPRLRFLLELGDMIYADVPRYEGPAMESYRKLYRNVFASSSFRRIYESIPVIGMYDDHEIINNWSGEGYHKHSLVNANTSLPNATFEHNENDTPLSPPAGLHAGLRAWSEYIGRANPPPVSRDENYFSFRYGDTAFFVLDTRKHRTHPDSNIENPTILGSEQHHALMSWLAEVNHTATFKFIASSVPFTSLWGGPLDLDGRYDGWSFYVDERKQLLDVLEYVPNVILLSGDRHEFAAVSFRDSVVEFSTSPLSMFYIPIRTLAQEHSMDPPGSETLLKYLPDGNHKWTEFEVDTRDPKNPAVHVRVYVDGLEAWQLRVDGRPITRPQSALGKLARSLLELLGFRKREWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRZ1</accession>
    <name>A8PRZ1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732384.1">
        <property type="nucleotide sequence ID" value="XM_001732332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRZ1"/>
    <dbReference type="FunCoup" id="A8PRZ1">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRZ1"/>
    <dbReference type="GeneID" id="5856690"/>
    <dbReference type="KEGG" id="mgl:MGL_0159"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0159"/>
    <dbReference type="InParanoid" id="A8PRZ1"/>
    <dbReference type="OMA" id="KTQRYGT"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="111"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="508" mass="54693" checksum="E1030C1F0C5CF9D1" modified="2008-01-15" version="1">MSTRGGERTCSEVAKQAREAFDRVQKHLSLDDAAHADGVRAKALHAICETLQEAHDEIRQANETDVREANELVRQGKLSAQLVARLDLFSKRGKWESMIQGVADVASLPSPLDICTRATRLAAAHPGDDERDATGALDLYRVTCPIGVLLCIFEARPEVIVNIASLAIKSGNAAILKGGKESKHSAHVLSRCISQALAKSGMPAHLIQMVESREEIQSLLHEEKYINLVIPRGSSELVRHIQREARMPVMGHADGLCTAYVHSDAPEKLAIETVLDAKLDYPSACNAIETLLVHRAHLSSAGLWPKLARALICAGVRLHCDEASRASVLSSGLSEAEANLVLCATPADFDTEFLDLDLAVRVVDSVDEAVEHIQQHGSGHTETILCAPLSSNDHGTSASSMPPAAKDEDTYAQHSAAEIFTRSLSSSSVYVNASTRFADGFRYGFGTEVGISTGRIHARGPVGLEGLVTYKYVLRSSGGGAQTASAFAPGEHQRRWAHEPIEAVYPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRZ4</accession>
    <name>A8PRZ4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_0161</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732386.1">
        <property type="nucleotide sequence ID" value="XM_001732334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRZ4"/>
    <dbReference type="STRING" id="425265.A8PRZ4"/>
    <dbReference type="GeneID" id="5856692"/>
    <dbReference type="KEGG" id="mgl:MGL_0161"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0161"/>
    <dbReference type="InParanoid" id="A8PRZ4"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="16">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP45172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="150" mass="16717" checksum="58F7EA8F4AB27C79" modified="2008-01-15" version="1">MDTLTFGAPILLKNLTASEQKKLPVTEVHLGKALEELDMPMEQFVDLCMLLGCDYLDPVRGVGPKKALKLIQDHRTLERILEHLKQADDAKKAKASDAHGSDDDEATSIKKRPGGIQVPDFWPFQEARELFLTPEVQDGHTVQVCIEEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS06</accession>
    <name>A8PS06_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732393.1">
        <property type="nucleotide sequence ID" value="XM_001732341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS06"/>
    <dbReference type="FunCoup" id="A8PS06">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS06"/>
    <dbReference type="GeneID" id="5856699"/>
    <dbReference type="KEGG" id="mgl:MGL_0168"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0168"/>
    <dbReference type="InParanoid" id="A8PS06"/>
    <dbReference type="OMA" id="AMVSPII"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="124" mass="14326" checksum="29D74E5FC9C4F5BD" modified="2008-01-15" version="1">MSNAHKWVTLLSEDGYRFIVDREWAMLSGTIRTMLSTDEGGFFEAESGICQLQIRGQVLEKVVEYLQWHARYAQHDQYPIKEFERKIPPELALELLMAADFLECTLSKGYAFLHTDTSFSVVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS52</accession>
    <name>A8PS52_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732420.1">
        <property type="nucleotide sequence ID" value="XM_001732368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS52"/>
    <dbReference type="STRING" id="425265.A8PS52"/>
    <dbReference type="GeneID" id="5856726"/>
    <dbReference type="KEGG" id="mgl:MGL_0195"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0195"/>
    <dbReference type="InParanoid" id="A8PS52"/>
    <dbReference type="OMA" id="RLWNARY"/>
    <dbReference type="OrthoDB" id="3363631at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="225" mass="25297" checksum="8523E9D965D319C5" modified="2008-01-15" version="1">MPQRLWNARYPIGAGRGQTWQALSPSTGGSADATNSQMPASIDEMQLQNKLEALDAEYSSLILSQLDSQRVHYEAKMTKMQEESVSTSTFKQVCDERDKLQVELGSMTQALSSAQSTIKKQDTQLRRSIENLRTTRNELEQEKSLSKALCDQVQKLMRGQDSLQRQMDDVTEQLRDMTFFVSARDKIEQQTDDTLGIAGGDVIVPNPSDGQRQRQRQTHGGKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSA5</accession>
    <name>A8PSA5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase alpha subunit B OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732447.1">
        <property type="nucleotide sequence ID" value="XM_001732395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSA5"/>
    <dbReference type="STRING" id="425265.A8PSA5"/>
    <dbReference type="GeneID" id="5856753"/>
    <dbReference type="KEGG" id="mgl:MGL_0222"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0222"/>
    <dbReference type="InParanoid" id="A8PSA5"/>
    <dbReference type="OMA" id="HEERTWK"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="4">
        <location>
            <begin position="92"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="254" mass="28477" checksum="6FDA018874BED19A" modified="2008-01-15" version="1">MDDLSSLLGASPSQGGNETSWNETGHEERTWKTNLSVAETYHEQMPSTWTPAYWQGRTPPTAPRVALAVSTDLKQWNYRYMFEKKGERSLELDTRLGEMGDVIQQAFGLSKDWDDPTIPSQESVYTVGRICARLDPPSMRGKSSVDADGPSSLKLTMSNLMLETSRMVGNGQRVPLVIDAKCRIHYAWTDATAQASNVLGLFPGMIVGMKGRNGSGHRFVAEELFIVRRHSYLSEPTYASHLHFHTQRHNVVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSQ1</accession>
    <name>A8PSQ1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732522.1">
        <property type="nucleotide sequence ID" value="XM_001732470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSQ1"/>
    <dbReference type="STRING" id="425265.A8PSQ1"/>
    <dbReference type="GeneID" id="5856828"/>
    <dbReference type="KEGG" id="mgl:MGL_0297"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0297"/>
    <dbReference type="InParanoid" id="A8PSQ1"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044716">
        <property type="entry name" value="LEUNIG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44376:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL COREPRESSOR LEUNIG ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44376">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF FILAMENTOUS GROWTH FLO8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="576" mass="60208" checksum="39F9335F05D506C5" modified="2008-01-15" version="1">MSAKEEADVDNAVGSSPSQGNEASSATATHASTPTTTKHTDSLNSTAETSKDATNTTDAGNATDLTEATYMAGSTKPPSFSLEARDSEHNADLGSAKTAAPSMPMGPEPAAHTAAAPRLSNEDPPHSSTTPSEVNDTRKRAGSPLKDAHMPDKRHRMDEVPSSETDHAGEAHTNVHQPEAEQEATKETVLDALNAATTAPESVTSAARPRAMPTGDVTSVSEDGPKADTPHPVRPLPTSITGLSGSGNAAQMHEDIVRNEHSHKLDLYVWEYLHYRKLHKTAAAFVEETDLPENPEIPIRLPRGFLYEYWSVFWELFNARSSYNHKQANLFTEFLESRRHQRWKEATKPKSYDAAMFSDPGSTAAATAATAAVTAGVLPAPATSSTAAASAAPVPPAVSDVPPGSVPPPPFVMPGHETANALAPPVQILMMGHGASNTQSQLPATISQTKAPTSTQVPPSASSTQQYQPSTPQQLPGSDCQTPTAQSQAAMQPASAPPTPSSNATMSTGSAPAIPSAVQPSAQNQAPTFHTQHVGAMRGQPMSATQPNAATGPPTPVLSSLPTTFKVGQQTSALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTD5</accession>
    <name>A8PTD5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732632.1">
        <property type="nucleotide sequence ID" value="XM_001732580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTD5"/>
    <dbReference type="STRING" id="425265.A8PTD5"/>
    <dbReference type="GeneID" id="5856938"/>
    <dbReference type="KEGG" id="mgl:MGL_0407"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0407"/>
    <dbReference type="InParanoid" id="A8PTD5"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="284" mass="32225" checksum="696B18A88090263E" modified="2008-01-15" version="1">MSDLLPIVGEFSHGFDTEDERMRIHVALAQVQPNEAAHGNVYDVLPRMKQLLCSASELGADVVVFPEYFLTGSSHEAWRQSHTHDPLDSFSDVPVWLEDIRCMAREFGTAIVTGSAVLRHANKRASPLYNTTYFLDARGDIKGAYTKRNLWHAERAVLTPATDVSHPKDEYPPVFMFETRRGLRVRASMLMCWDLMFPESFRRLFVPPGCDQQLSELDKPNEWTGPDIVFAPTCWYADDSGTEAQVWNKDCEAACLDAICVARAMENECFDHRIPRPVDWVGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTF3</accession>
    <name>A8PTF3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732640.1">
        <property type="nucleotide sequence ID" value="XM_001732588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTF3"/>
    <dbReference type="FunCoup" id="A8PTF3">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTF3"/>
    <dbReference type="GeneID" id="5856946"/>
    <dbReference type="KEGG" id="mgl:MGL_0415"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0415"/>
    <dbReference type="InParanoid" id="A8PTF3"/>
    <dbReference type="OMA" id="RKRPWIG"/>
    <dbReference type="OrthoDB" id="21643at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="672" mass="74175" checksum="F7AA58CA9D414052" modified="2008-01-15" version="1">MAGDASTLITKRLHISGLTSQFNRAALSERLSSFGTVLDLEGSDDSYVNAVGERRPYAFVTLRTTPQQLAKCMNTLSGAVWKGAKLRVGEAKPPWHERLAAERTKHTPADEQCTALEKRKKQLRKRPWIGMEAHDMRPMTLERVNETHAWGWKSTPAGHLIRPMHMRPSHPIPKPADHEMRANLHGRHALSRAPRVTIDPTRYHREHLSERMFDAMTDHDDTHLHWVWDSDAHEWLAYNEKGHCVGQEAGPARRTRPVQLPLGPSGDSCASWGVHRMDSDREEESLEPTSPSHDVPDALFDKSEVSEELFDTPPQTKSTSWWDEPEPEWKLEPKPAPSRSPTPERPSNASGQHLDSMHDREATYSTAEPWNDSDFSDGYEETEHAPASSTNERERALGMLQSMFGSQDSEAPEPAESSSILMPDEGRSEVHAAVEGRPLAGEGNSSVHATLHADQIKGPTTASAPSSSTVLPARSLQQQQATAHDAPAASHTADGDADGDATANPIRLDRLKDMFQPTEESGAFTLFGDIDEENMSMDDDAVAGILGHASARTESDHADQRLSRPPTSSTTTAAATTHIPPFTTPFTLSQQIPSLLPTLFQLGSTPFWQVDSDEAIRENWLAKRSELTQTYRSMHRDAIKKRRRRVAGSRAAGAEHGGSAPIRGVLQDPSSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTG4</accession>
    <name>DUS3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName>tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="1">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>mRNA-dihydrouridine synthase DUS3</fullName>
            <ecNumber evidence="3">1.3.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName>tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DUS3</name>
        <name type="ORF">MGL_0420</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="3">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="3">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="1"/>
    <dbReference type="EC" id="1.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732645.1">
        <property type="nucleotide sequence ID" value="XM_001732593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTG4"/>
    <dbReference type="SMR" id="A8PTG4"/>
    <dbReference type="FunCoup" id="A8PTG4">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTG4"/>
    <dbReference type="GeneID" id="5856951"/>
    <dbReference type="KEGG" id="mgl:MGL_0420"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0420"/>
    <dbReference type="InParanoid" id="A8PTG4"/>
    <dbReference type="OMA" id="WSYIAEC"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000341599" description="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]">
        <location>
            <begin position="1"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type 1" evidence="4">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type 2" evidence="4">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="401"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="609"/>
            <end position="611"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="633"/>
            <end position="634"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q06053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q5SMC7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9UTH9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="766" mass="85256" checksum="57829EC7B95EBF44" modified="2008-01-15" version="1">MSVYKPGIAPIKAQFLRTAWPARSEALDGSTETGADSEPTAFVPDDEPDGKPEQENPTDAAAPTTSSGANRAQDGEQDKPRKRARGQNKGRTFTRTEDNIALCTQIATGRDACKFGDSCKFTHDLCTYLEQKPRDIETPPHPVSSHECVRFVPADERDVYLATLYEHAVMQDTKRIKKNTDVTADAHPASGSTTPSAPTAPTTHDTVQASVVLGTTCPYFQERGTCPMGWKCRFLGAHVRRLSASCRVLGAEAQGMLGTGLELVEDEAKKHAWLHRSPYMRNEAQPESDQVNWLASDVARRLRSRKYTFDKAPAITSALRKEVDMLSAMTPAEAASTEVGKGPLRVNYEHERLVADPSATLEACEDALRNGGNDDAAADTARVRPCEKRRLQWKGDLYLAPLTTTGNLPFRRLCASFGSDIHCGEMGMAESFLQGHASEWSLVRRWEGERIFGTQVCGAKPELLVPTAEVLAREVGRGLDFVDVNCGCPIDLVYNKGAGSALLDHANKLGRIVRGMSEALGEIPLTIKLRTGTTSKPTTHKIFARAQTEWGVGGLSLHGRSRKQRYKNDADWAYIRTCVDTLHDAVRTWNEEPQHADEPDMVPVPVYGNGDVYGWRDYYDHLEHAHVDGTMIARGALIKPWIFTEIKERRDWDISSRERLDMIRQYASYGLTHWGSDTQGVNTTRRFLCEMLSFTHRYVPLGLLDHIPVRMNDRPPPFHGRDPLESLLSSPSAHDWVRISDMFLGPAPPDWHFTPKHRSNAYEQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUC7</accession>
    <name>A8PUC7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732062.1">
        <property type="nucleotide sequence ID" value="XM_001732010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUC7"/>
    <dbReference type="STRING" id="425265.A8PUC7"/>
    <dbReference type="GeneID" id="5856358"/>
    <dbReference type="KEGG" id="mgl:MGL_0655"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0655"/>
    <dbReference type="InParanoid" id="A8PUC7"/>
    <dbReference type="OMA" id="MHRIRRY"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="72"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="194" mass="21654" checksum="00A1471F3C4921D8" modified="2008-01-15" version="1">MSSTDVRPTNNYFSRIYERASELVNQVKNVAAEEARPLLHGESHASYQGTQDNSVPVPKPRPVQTPVKVEAKVWFANERTWISWLRASLLIGTLALALFNSASYYDPKPSTSPDVPDVPGNPAAAKVVRVFGMVYAFISAFVLLWGLYSYQRRVTLIKMRWPGSFDDLIGPPVVCVVTFIAVLANFIIAVHQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUC9</accession>
    <name>A8PUC9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732064.1">
        <property type="nucleotide sequence ID" value="XM_001732012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUC9"/>
    <dbReference type="FunCoup" id="A8PUC9">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUC9"/>
    <dbReference type="GeneID" id="5856360"/>
    <dbReference type="KEGG" id="mgl:MGL_0657"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0657"/>
    <dbReference type="InParanoid" id="A8PUC9"/>
    <dbReference type="OMA" id="YSAHDHE"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="9724" checksum="1BD7FEA3D07193C4" modified="2008-01-15" version="1">MRTHTSQSDKLVELTTAAGVPVEPIWASLLAKALEGKDVKDLLTNIGSAGPAVAAAPAAGAAAGGEAAEEPKEEKKKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUD0</accession>
    <name>A8PUD0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trehalase</fullName>
            <ecNumber evidence="3">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732065.1">
        <property type="nucleotide sequence ID" value="XM_001732013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUD0"/>
    <dbReference type="FunCoup" id="A8PUD0">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUD0"/>
    <dbReference type="GeneID" id="5856361"/>
    <dbReference type="KEGG" id="mgl:MGL_0658"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0658"/>
    <dbReference type="InParanoid" id="A8PUD0"/>
    <dbReference type="OMA" id="WLFMMTK"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="5">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="774" mass="89125" checksum="F4B965907F7F6078" modified="2008-01-15" version="1">MSRGESELERPSDLHGDHGGNHVGVRVGNGENPSVAEHAAVSAVPRLRDMQRSSSMWPQQTMPLVNPRNEQRPPNVRRWSSGVESLQKLGPRQFHMEVQPTIQRLLEQEDTDGDNQISIADKGPKTITLETVDGPSSEIRGTYMLASLLQELALAMDRGEQHLIVSEACLAENPIDKLSRMIRTMFWNNLTRRIDAEGLQKVLLDPKNRSAHRGQILYVPAGEPEMIAYYRRVAEERPALRLNVEVLPKVCTPEYVRDLNQRPGLLAIAMEKVQDEKTGQIDLRGIPFVVPGARFNELYNWDSYFIALGLLEDGRLDLAKGPVDHFIFEIQHYHKIMNGNRTYYLLRSQPPFFTDFTRRVYERMLSDQPEHKAQHKAWLHRALCAAIKEYHMVWMSEPRFDPNTGLSRYHPEGLGVPPETEASHFTALLRPYAEKYQCSVNEFTRMYDNQEVQEPDLDEYFRHDRAVRESGHDTSYRVERKCADLATIDLQSLLFKYERDIGELIRDEFDDELELTDEFRLDTSHGAEAGRLVSKLQRSAEWFERAAFRKKQVDAYCWNEGKGLYYDYNLRKGEQSLYESVTSFWTMWSGMASPDQAARMMRLSLRKFEVTGGLVTGTEESRGPVSLSRPNRQWDYPYALPPHQMLAWEGLKRYGYMDDARRLAYRWLYMITTAFVNFNGLVPEKFDAVALSHLVNAEYGNQGTQFAYVPREGFGWTNASFQVGLTYLSSHMRKAVAVCQHPDDYFANMRRSASFGKSVPALIRRLSSSFSEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUR7</accession>
    <name>A8PUR7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732162.1">
        <property type="nucleotide sequence ID" value="XM_001732110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUR7"/>
    <dbReference type="FunCoup" id="A8PUR7">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUR7"/>
    <dbReference type="GeneID" id="5856468"/>
    <dbReference type="KEGG" id="mgl:MGL_0755"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0755"/>
    <dbReference type="InParanoid" id="A8PUR7"/>
    <dbReference type="OMA" id="IYMSETQ"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000051">
        <property type="entry name" value="Probable MDR1-Mac1p interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="265"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="748" mass="84918" checksum="10722EEB46779678" modified="2008-01-15" version="1">MSTIVHSLRDYRPPTRAQQFAHAFGLPPTEGPYVDEAGNRAEILSAILSLSNPDSNEVREDLVFAGRLTLTPSFLCYASQGDRGRGCRVAIPLATIRRVERLNTRDAVFALSITVWHGMQLVFQLNALRPSCEGFCNAMRDRLRAHLGEMKQLKPFLATCYSEALLQGALDTHVSAKGKHREDVQEGMGAATSSEPSSSLTPPSAPADETPMYQIGLGASFGFPGDPKKLKDKSKTRLWTEYLRTHGRNITIVRYPQFTRLVQVGLPNMLRGELWEVASGSIFQRMAHSGEYAAILKEHEGQSNTSMEEIEKDLNRSLPEYAAYQTPEGIETLRRVLVAYSWKNRELGYCQAMNIVVAALLIYMSEEQCFWMLDTLCERLLPGYYTQSMSGTLLDQKVFEHLVQQTMPVLHEHFIKYDMQLSIVTLPWLLSLYINSMPMVFAFRIVDCFMAFGSQVLFQIGLAILKINGEAILSVTDDGTLIGLLRNYFRTLGDSAYPESRDERRQQITRFQQLLVIGFREFGIITNDLVDQERKRFRQQIVQEIEGFARRSAIRNLKDYGHFSKAQVSLIYDHVVESIYRARNAPDSLTGGEKPVTVSDPKQDLKEMRVNFTTFRIFLSEMATWARDEYIVMNGLQERIERRIPDQTFARRLFDFWDREHCGSLTLQNIITGLDEIMFLDCDLAGTTAWFFRLHAGGKEKLSKNDVLALSESLLFMFRNEPGDEHLGSVSALITQAFELGDDESKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUT9</accession>
    <name>A8PUT9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0771</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732178.1">
        <property type="nucleotide sequence ID" value="XM_001732126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUT9"/>
    <dbReference type="FunCoup" id="A8PUT9">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUT9"/>
    <dbReference type="GeneID" id="5856484"/>
    <dbReference type="KEGG" id="mgl:MGL_0771"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0771"/>
    <dbReference type="InParanoid" id="A8PUT9"/>
    <dbReference type="OMA" id="KFFVFPC"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="8">
        <location>
            <begin position="46"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="9">
        <location>
            <begin position="887"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="852"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1005"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1094" mass="121508" checksum="EB1A867F70AE6C7E" modified="2008-01-15" version="1">MLSSGYEQVGPASVSAASRQEAQDGARPTQAAPARTTHTQSIPAKPLFELGRIQYALPGPLLYIAAAANKLLLCIAPVDATPMRLVYLDLDDPSRTQEALLPPPIQARGARWRQPTESTRVFIDPTAQHALACTGTHTYYWTPSWPRARRVQQLDGVPVTAVGWGRPRTDPPVPLPSLPGTRKWIWTPPVLLGTARGDLVETTITAQVGEDRFDLFDRWARKSAGSIDYPLERGTYRLYSLASDAHPITGLSVEMKEKCALIIVATSSRLYEFVGEVSTSVSAEASPVFLRVFDSYKQSLQPHWKTDLPPGLGTLLTVTSPVASPPHGSTARMMAWLTGAGIYAAQIEAGTGSSGADLVVLPRMTESPIAMGRTPLHYVLVYADSLVCMNALDPEVKYEVPLQLQSHEQVQGLVVDCSSHTCWMYTSMGGILELLVHDEARDMWHLLLKRQLFASALKFCRDDESRKQVLENQGNALLASGNALKAVECYAEARSPSFEHVALALMDAAADNALRRYVKLCLDALPRTARVQRLMLATWLLELFVRALHVNEKESEQHHHLMSETESILRQHDADLDPSATYALLARQGCIDVWITYANIRHDVRKILQHWIDQKCWDKALHALSSQSSPDMYYQFAMVLMRNAPEATVQCWQRCADSLDIERLIPALLQHKPATTHSTDFSLVYLQYMIDVQGCKSPAAHALRLTRLVARDNETPALLAFIENASPEALDLSYALRVCSSAGRREACVRLYARMHQYENAVHLALDADDVDLACLCADLAAGQPALQRELWLQCAKYVVHTQATMEEAMKFLLRTDLLTVEDILPFFPDFSVIDGFKTEICDTLESYVARIGALKEDMDRTSNTAANIQQDIEQLSKRVMEIDADHPCRQCGAPLLERQLYLFPCRHGFHADCLTQLVAQHLSPQRLRRLLQLQNELNAVTVSTAAADTHSASLQSSKASPLPLSNSLERLREHVRPQAIVDAIANGFTVGVTNSRRAFVPHDPSTSLKHISSKNTQDQQILQQQPHHLHHRDSDIKSSSTQPSARTDDVDERRAELNSIVAGTCPICTWSVQEVAAPFTDDKDSEDGDDWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUV3</accession>
    <name>A8PUV3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0780</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732187.1">
        <property type="nucleotide sequence ID" value="XM_001732135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUV3"/>
    <dbReference type="FunCoup" id="A8PUV3">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUV3"/>
    <dbReference type="GeneID" id="5856493"/>
    <dbReference type="KEGG" id="mgl:MGL_0780"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0780"/>
    <dbReference type="InParanoid" id="A8PUV3"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="69"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="478" mass="52270" checksum="57586FDB8B1597C0" modified="2008-01-15" version="1">MKMPLPFGLTSRRAIQSATRNYVTPSSASRAVPSVALNETGDDGPLSNDQLVERILGKGASHRGATRPIYMDAQSTTPVDPRVLDSMLPYYVEQYGNPHSRTHAYGWETEAATDKARKHVAELVNADPKEIIFTSGATESNNMILKGVANFYRAKKNHIITTQTEHKCVLDSCRNLQEQGFEVTYLPVQSNGKIDLDMLRKELRPTTSLVSIMSVNNEIGVIQPIKEIGEILKTEGLELSKQLGKGMPKPFFHTDAAQAVGKIPIDVNEAGIDLMSLSGHKLYGPKGIGAAFVRRRPRVRLDALISGGGQERGLRSGTLATPLVVGFGEAARLAKKEMAFDHAHVSALSKRLRDNIMSRVEMVLLNGDPDGYPGCTNLTFQYIEGESLLMALKDICLSSGSACTSASLEPSYVLRALGLDDANAHSSLRFGIGRFTTEEEVDFVCDKIVAVVQRLRDLSPLWEMVQEGIDLNSIQWSG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUY7</accession>
    <name>MDL4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Secreted mono- and diacylglycerol lipase MDL4</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDL4</name>
        <name type="ORF">MGL_0800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Microbiology" volume="162" first="1069" last="1079">
            <title>Secreted lipases from Malassezia globosa: recombinant expression and determination of their substrate specificities.</title>
            <authorList>
                <person name="Sommer B."/>
                <person name="Overy D.P."/>
                <person name="Haltli B."/>
                <person name="Kerr R.G."/>
            </authorList>
            <dbReference type="PubMed" id="27130210"/>
            <dbReference type="DOI" id="10.1099/mic.0.000299"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6">Secreted lipase involved in Dandruff and seborrheic dermatitis (D/SD) probably via lipase-mediated breakdown of sebaceous lipids and release of irritating free fatty acids (PubMed:18000048). Shows activity against monoglyceride and diglyceride substrates, but not triglyceride substrates and does not exhibit regio-selective production of diacylglycerols (PubMed:27130210). Cleaves oleic acid from 1,2 isomers of diolein on both the 1 and the 2 position of the glycerol backbone, resulting mainly in free fatty acids but no monoolein is detected (PubMed:27130210). Shows activity on monoolein and liberates mostly free fatty acids, but can also perform the reverse reaction and produce diolein (PubMed:27130210).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732207.1">
        <property type="nucleotide sequence ID" value="XM_001732155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUY7"/>
    <dbReference type="SMR" id="A8PUY7"/>
    <dbReference type="GeneID" id="5856513"/>
    <dbReference type="KEGG" id="mgl:MGL_0800"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0800"/>
    <dbReference type="InParanoid" id="A8PUY7"/>
    <dbReference type="OMA" id="YICSKER"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00120">
        <property type="entry name" value="LIPASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002724993" description="Secreted mono- and diacylglycerol lipase MDL4">
        <location>
            <begin position="20"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="55"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A8PUY1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="18000048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="304" mass="33863" checksum="5BB0AB49A349E5A3" modified="2008-01-15" version="1" precursor="true">MRFGGVVSLVLGFIVSVLAGPLHPRAASSTQQPVDVTYKIEPFTQAAGLVQQTYCSPSSYEPGLQLGDATFLWRIGDGDQRQRVNLYHSESLGIAVAIQGTNGSSTRSILNDFQYNPFDPDERYSQYYPKGAKIMNGFQIAYVKLVDDIFRALKKYKREKNESRVTVIGHSQGAAIGLLAAMDIELRLDGGLFRSYLFGLPRVGNPTFASFVDRTIGHKLRWAINGRDWVPTVPIHIYGYQHPSNYIWIYPGNSTNWKLYPGQENVHGIPTVPRVFNNNDHQGIYFHTQIGGVDGECPARVGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVI9</accession>
    <name>A8PVI9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731614.1">
        <property type="nucleotide sequence ID" value="XM_001731562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVI9"/>
    <dbReference type="STRING" id="425265.A8PVI9"/>
    <dbReference type="GeneID" id="5855920"/>
    <dbReference type="KEGG" id="mgl:MGL_0882"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0882"/>
    <dbReference type="InParanoid" id="A8PVI9"/>
    <dbReference type="OMA" id="LYMFVNI"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="60695" checksum="6E3FB7C82772EB05" modified="2008-01-15" version="1">MVDSSPIKEEKHFITEDSTLVDGHIDEESRPVNATEDSQTGHHEDIPPAEVHYDELPQGRQLGTISAIFLMVNRILGTGVFSTTSTILQQGGSVGMSLIYWVIGGLIAGCGFAVYAEFATAMHRNGGELNYLQHVYRKPKHMVASMYAAQALLLGQAAGNANAAGQYFIRAGGKSASEWGSKGIGIGIIMFALFMHGTMLKWGLLFQNTVGLFKVVILLLIVFAGFAALAGHTKGPTPHNFSNAFDNTRSDIYGVSQCIYNAIWSYVGYSNLFYALGEVQNPARTMKIAGIVSLTTLTILYVLCQIAYFAAVPLDEVLGSEQIIAAAFFKHMFGERSAQALSVFVALSAVANVFAVLFAQGRLNQALGRDNIIPFAKIFASNRPFNTPLAGLTWHAIVTLILMLAPPQDSAYQLVLSIAQYPLNIVNTAVGLGLCLTYLPHNSRFKLSWLREWHPLFRASFPIALFFTLVSLFLVIVPWIPPPAGEKTATNGDIWYGLAPAVASGFFGAGFLYWFVWYVMMPRIGKYKLVERQTTMKDGTPVMAFDHVPRASLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVR8</accession>
    <name>A8PVR8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0939</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731671.1">
        <property type="nucleotide sequence ID" value="XM_001731619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVR8"/>
    <dbReference type="STRING" id="425265.A8PVR8"/>
    <dbReference type="GeneID" id="5855976"/>
    <dbReference type="KEGG" id="mgl:MGL_0939"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0939"/>
    <dbReference type="InParanoid" id="A8PVR8"/>
    <dbReference type="OMA" id="WRYPHVQ"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="102"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="516" mass="56988" checksum="2E7E7B65EC17A458" modified="2008-01-15" version="1">MDGAVRPSATMDMLEPCPMPGQKRTILTYLFASSDKAISRRAKFTEEVDRSSVTAPDNASINNGSADEKGKPRIEDGVIEQMNGIYGEEEPRPLHRTLGRFGAFFNMIAFSIALGILSIPMAVATIGIVPFILLCMLFSFTAWYNGYNYWRLAMMYPGVHNLQQAGELLYGPIGGVIFAFLQGIFSIFVQGSHIILGGYAFWYLGWKDCMVGLAAVFAVISFVFSLPRSYKLFSVFSAISFTSIITVVIIAMISSGVTGPVNKDPEDPPRKLLAFGATSKVPHSFLDGVLYTSNIFVSFGSTTAYLPIMAEMHHPRDFMFSLNLLVAISFVLYVIVGCIMNYNLGQYTKSPSLGSLSPIMVKVSYGLGLPTILVAGCCSGQVTGKMLLVNVFRGSWRYLLDRNWTFWGIWILINISSWALAFVLAELIPFFNTFLGLMASVFWTIFLGFAPLFYFWRHQHDYLHNWRNRLGTLIALGVIGIAGFIMVAGTWAVAVAIRDLYDQGVVGSPFSCGMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVW8</accession>
    <name>A8PVW8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731705.1">
        <property type="nucleotide sequence ID" value="XM_001731653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVW8"/>
    <dbReference type="STRING" id="425265.A8PVW8"/>
    <dbReference type="GeneID" id="5856010"/>
    <dbReference type="KEGG" id="mgl:MGL_0973"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0973"/>
    <dbReference type="InParanoid" id="A8PVW8"/>
    <dbReference type="OMA" id="PGCMKLF"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17708" checksum="684307D078199BCE" modified="2008-01-15" version="1">MGAVASRSAGEGDAAANPRESSPAPLANRDFETLRREELVLEAAANPLEDIPSCLTLFDKWLTCYALGEQFRSVYRYGTIANCAPRREDFKFCLTLRQYDPETRRAKWLERRAEASAHQRKGVRTSEAVWEMRRDPLMDPAFVDPSYPLPSCTYPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW15</accession>
    <name>A8PW15_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1005</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731737.1">
        <property type="nucleotide sequence ID" value="XM_001731685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW15"/>
    <dbReference type="FunCoup" id="A8PW15">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW15"/>
    <dbReference type="GeneID" id="5856042"/>
    <dbReference type="KEGG" id="mgl:MGL_1005"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1005"/>
    <dbReference type="InParanoid" id="A8PW15"/>
    <dbReference type="OMA" id="MEKWPAD"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP44523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="106" mass="12380" checksum="529D3C7C9B7E0F32" modified="2008-01-15" version="1">MYSAHNETFEEFNDRFVKFFEGVEDQFEAQRGLNNAFAHDLVPSPEVIESALKAARRVNDFSLAVRIFEGLKFKTENDNQYKQYLEVLKPLREELGVPLKEEIYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWB0</accession>
    <name>A8PWB0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731792.1">
        <property type="nucleotide sequence ID" value="XM_001731740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWB0"/>
    <dbReference type="STRING" id="425265.A8PWB0"/>
    <dbReference type="GeneID" id="5856097"/>
    <dbReference type="KEGG" id="mgl:MGL_1060"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1060"/>
    <dbReference type="InParanoid" id="A8PWB0"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="242" mass="26399" checksum="9410B673D83A853B" modified="2008-01-15" version="1">MATALCADARIAPTDDDDACAIRLLASIECVLPYAGTHHGAHDALHAFLPSLVSATHLYEARGTFTRPSEPIHRERFAYATWDMLFRLVSSSATPGAKMVAAHILPLIIERCRCVLQAYLDDVRIRGSIPLPRVRLEEVNFLLHTLLTLQVPSEVNEHCQHSFAQDAHLFLLGKVLDEIATMPATSCAVSQKACIGTSLPPLSSADDGHVSTQSIRRRHSCPTTPQALAAAALTRRMHVLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWN1</accession>
    <name>A8PWN1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731890.1">
        <property type="nucleotide sequence ID" value="XM_001731838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWN1"/>
    <dbReference type="FunCoup" id="A8PWN1">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWN1"/>
    <dbReference type="GeneID" id="5856195"/>
    <dbReference type="KEGG" id="mgl:MGL_1158"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1158"/>
    <dbReference type="InParanoid" id="A8PWN1"/>
    <dbReference type="OMA" id="EINQPRI"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="268" mass="29106" checksum="9EAE1D289D44E341" modified="2008-01-15" version="1">MRASLVNQLRVLVPVKRTIDYAVKIRVASDGKGVDQNVQHSMNPFDEIAVEEAVRMRERNKDAVKRITVMSAGPAKAQDVLRTALAMGADDAIHVEVPGPIEPLAVSKILRAIVDKEASEDEIGMVILGKQAIDDDASQTGQMLAGLLNWPQATFASKIELDGKGDKGDKVTVTREVDGGLAVVETQVPLVVTTDLRLNEPRYASLPNIMKAKKKKVAKYSVADLGLEKDIESRLETLKVAEPPQRQGGAKVENVDELISKLKEAGRI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2025-02-05" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWQ8</accession>
    <name>CIAO1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CIA1</name>
        <name type="ORF">MGL_1185</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731917.1">
        <property type="nucleotide sequence ID" value="XM_001731865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWQ8"/>
    <dbReference type="SMR" id="A8PWQ8"/>
    <dbReference type="STRING" id="425265.A8PWQ8"/>
    <dbReference type="GeneID" id="5856222"/>
    <dbReference type="KEGG" id="mgl:MGL_1185"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1185"/>
    <dbReference type="InParanoid" id="A8PWQ8"/>
    <dbReference type="OMA" id="IREIRWS"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000382519" description="Probable cytosolic iron-sulfur protein assembly protein 1">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="179"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="244"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="319"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <sequence length="356" mass="39156" checksum="58D4BE8B73214592" modified="2008-01-15" version="1">MSQQNTVEGGFDLSSGVSDKKEWVFNLQEVIPTGHKRTVRSVAWSPNGEVLATASFDSTVGLWERIPENIRAEEGSDGPEWECFGTLEGHDSECKSVAFSYNGNLLASCGRDKSVWVWEAQPDADYECIGVLIEHSQDVKCVIWHPKEEILASASYDNTIKMYVDDPSCDWYCYTTLQAHSSTVWSLSFSPCGQFLASSSDDMTIWIWRRVSAAECVELGIQAHGNTPGRSGERWVPTYCIQGHFSGPIFSVNWAPGDSFDPRQALGKLVAAGADGKIIVFFLVRIYATLRGTYACAQSLEDNNPSRIFVHVGAQEENAHGSVDVNCVKWAPMNTDGSAPTMIASAGDDGEIRIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWT5</accession>
    <name>A8PWT5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731943.1">
        <property type="nucleotide sequence ID" value="XM_001731891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWT5"/>
    <dbReference type="STRING" id="425265.A8PWT5"/>
    <dbReference type="GeneID" id="5856248"/>
    <dbReference type="KEGG" id="mgl:MGL_1211"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1211"/>
    <dbReference type="InParanoid" id="A8PWT5"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="104" mass="11802" checksum="71564C6F63BABDE8" modified="2008-01-15" version="1">MLFRSAEAAALSAQVPRQGKTCFYAWVDQALEKVGFYFAVQEGGDFDTDYVVMSPTDKIILQGEKSSQEDYVFTANEFGEYSFCFENGSSTKEEKLVCIFHYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWW5</accession>
    <name>A8PWW5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1241</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731973.1">
        <property type="nucleotide sequence ID" value="XM_001731921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWW5"/>
    <dbReference type="FunCoup" id="A8PWW5">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWW5"/>
    <dbReference type="GeneID" id="5856278"/>
    <dbReference type="KEGG" id="mgl:MGL_1241"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1241"/>
    <dbReference type="InParanoid" id="A8PWW5"/>
    <dbReference type="OMA" id="AFDYYLH"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="450" mass="48222" checksum="A40F777BA35EF9AD" modified="2008-01-15" version="1">MSKAKAAISGDDALASLTRDPLDVVGQDLSSLRHNIAALLGSGHPSLDKIAKYYFAAEGKHVRPMIVLLMSKATNGLSPAWQAHRVAAVGEHVDLAMSRPDVLNDANPSATNPHIPQAAEASTHPYEPALQSTILPTQQRLAEITEMIHVASLLHDDVIDASPLRRGAPSAPSTFGNKLSILGGDFLLGRASIALARLRDPEVTELMSTVIANLVEGEVMQLKATDSEQVPVTDVQSARPSNEVMERFWFAYDQGSSSAMSTPGAPNALLFEFYLQKTYLKTASLIAKSARSATVLGGCGTWSNQQSDMTPQQRADAATVCDAAYTFGRNVGIAFQLVDDMLDFHATTEAFGKPSGGADLKLGLATAPVLYAWQQYPDSPLGTMVQRRFSEPGDVEQALSLVHKSEGMQRTAALARYHADVAQHALSMLPPSDARAALETLNQQIITRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX74</accession>
    <name>A8PX74_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731167.1">
        <property type="nucleotide sequence ID" value="XM_001731115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX74"/>
    <dbReference type="STRING" id="425265.A8PX74"/>
    <dbReference type="GeneID" id="5855474"/>
    <dbReference type="KEGG" id="mgl:MGL_1350"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1350"/>
    <dbReference type="InParanoid" id="A8PX74"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36859" checksum="627F837748B7723E" modified="2008-01-15" version="1">MLHKLRREAAPEIHVPVPRVRKVPDPVTDTSFSQRASHVPPDAYAHAPSADGLPQLMWPLEDQDQIRVCDPEDPELASTLRVVYAPGHAADHAMLWLEEDRILLTGDNVLGRGSTVFEDLIQYMYSLQRGLSLLDASKATPLGVTGTPMSGMSQENVLFPGHGPVIPKGKEALRRYLRHRVEREEQLIALFLCQPGDKGQVTNATAYPLRFINQACATVRTRQYTWTLRQFVSTLYENYSLRAYPAIARVLLLHLQKLSMRVSDLDKPPYALTEPINSTPRAMHAPLVQCMVRPSYQYTARPCPDLPRNDQEWREALDLPWQLVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX84</accession>
    <name>A8PX84_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731177.1">
        <property type="nucleotide sequence ID" value="XM_001731125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX84"/>
    <dbReference type="FunCoup" id="A8PX84">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX84"/>
    <dbReference type="GeneID" id="5855484"/>
    <dbReference type="KEGG" id="mgl:MGL_1360"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1360"/>
    <dbReference type="InParanoid" id="A8PX84"/>
    <dbReference type="OMA" id="TPDIDKW"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="132"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="281"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="363" mass="42586" checksum="E909110DBBD87F7F" modified="2008-01-15" version="1">MSVEEREQVPVNKNKRFRKDKPWDSDDIDHWKIERFTQEDNPHHFLEESSFATLFPKYREKYLREVWGHVTTALEKHGVACTLDLVEGSMSVRTTRKTFDPYIILRARDLIKLLSRSVPFTQAVKILQDDMACDVIKIGNIVRNKERFVKRRQRIIGPNGNTLKAIELLTGCYVLVQGNTVSAMGSYKGLKEVRRIILDCMKNIHPIYHIKELMIKRELAKDPKLANESWDRFLPKFKKQNVKSKKPAEPPKKKIYTPFPPPQQPSKLDLQLESGEYFLKPHEKKKSEMDKKLQAQAEHAVKREKEREKQFMAPEEPVPGEEPRIKRKKVDEEAPAKTEKDGKISSDNKRDKKEKKLKKRKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXC0</accession>
    <name>A8PXC0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">MGL_1396</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731213.1">
        <property type="nucleotide sequence ID" value="XM_001731161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXC0"/>
    <dbReference type="STRING" id="425265.A8PXC0"/>
    <dbReference type="GeneID" id="5855520"/>
    <dbReference type="KEGG" id="mgl:MGL_1396"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1396"/>
    <dbReference type="InParanoid" id="A8PXC0"/>
    <dbReference type="OMA" id="DAMFSYC"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="69"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="184"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="292"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="EDP43999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="446" mass="48860" checksum="CF8C1C78E9A1742A" modified="2008-01-15" version="1">MSMRSVVRTSNTLRLASRSAFAARSVASARLPQVARASVAPAARAFSSSVKRAEEFENPFGVNSLYKLTEEEQMLREVVRRYAETQVKPLVAQMDENEKMDPSIIKGLFEQGLMAIETSPELGGAGSSFMSAIIVIEELAKVDPSVSVLCDVHNTLVNTVLRKYANEHLQKKYMPILSTEKLGSFCLSEPNSGSDAFAMKTTVKKSDDGSHYIINGSKMWITNSAEAEFFIVFAQGDASKGYKGISAFAVEKDMGVEIAKKESKLGIRASSTCTVNFDEVKVPAENLIGEEGKGYKIAIEILNEGRVGIGAQMVGLAQGAFDRALAYTFERQQFGKPIAKFQGMQFQMAQIATEIEAARLMVYNAARLKEEGRPFTKQAAMAKLYSSQAAERAAGRAIEWCGGQGFTREQGIEKYWRDSKIGAIYEGTSNIQLNTIFNLTAKEQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXE2</accession>
    <name>A8PXE2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731235.1">
        <property type="nucleotide sequence ID" value="XM_001731183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXE2"/>
    <dbReference type="FunCoup" id="A8PXE2">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXE2"/>
    <dbReference type="GeneID" id="5855542"/>
    <dbReference type="KEGG" id="mgl:MGL_1418"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1418"/>
    <dbReference type="InParanoid" id="A8PXE2"/>
    <dbReference type="OMA" id="YVVMQAA"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="362" mass="41620" checksum="8B7351FF92A54CD9" modified="2008-01-15" version="1">MVLVMNLTSFAWSCYDGQLRTEAECDKEQRYERITKMPSFLEFFGYCFYFPGVLVGPSTRFHEYQLWASGKLYGPRMVPPPGRIVESLRETFTAVLALVLMIWGSGTYSYMRLTDYSDAVHTWPLWKRWVFIQVCGLVARFQYYGVWSLSNAGCILSGLAYNGIDPVTSKTKWTRCKNVYVAKLEFAHNWKELLDAWNSNTNIWLRECVYKRLAGNSKPKFGSFMGTFLASAAWHGIAPGYYIAFVTAALCQWVARSLRKYVRPIFYADPRRPDPTWFTMGQYTLAQNVYATLSNFVTITSVNYAVISFFTLSLRNSLGAYRAVYWHYHILVLFGIAAFRLGLGKPLRAWHVAPTPPMKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXT5</accession>
    <name>A8PXT5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-related protein Rab-18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731338.1">
        <property type="nucleotide sequence ID" value="XM_001731286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXT5"/>
    <dbReference type="STRING" id="425265.A8PXT5"/>
    <dbReference type="GeneID" id="5855645"/>
    <dbReference type="KEGG" id="mgl:MGL_1521"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1521"/>
    <dbReference type="InParanoid" id="A8PXT5"/>
    <dbReference type="OMA" id="RVHKMDV"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24888" checksum="CA6FDBEFD699F853" modified="2008-01-15" version="1">MGEPATTAELPTLKLLLIGSSGVGKSALVRRYTDDVFVEEDAAATIGVDYKIKSLCVDGKWFKLSIWDTAGQERYRTLTSSYYRGAQGVVILYDVTDLRSYEDVPQWVHELRTFEGDVPPVCLLAGNKVDIAEERQVSTEQGQAYAQENGMLFVECSAKAGQGVDHAFDELVRKVVSTPALWLHVAPGVRRPGDRIPGGAPDAGGTISLSSVTDSMNNSWDAVQQRCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXW4</accession>
    <name>A8PXW4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731356.1">
        <property type="nucleotide sequence ID" value="XM_001731304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXW4"/>
    <dbReference type="FunCoup" id="A8PXW4">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXW4"/>
    <dbReference type="GeneID" id="5855663"/>
    <dbReference type="KEGG" id="mgl:MGL_1539"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1539"/>
    <dbReference type="InParanoid" id="A8PXW4"/>
    <dbReference type="OMA" id="LPQLAYK"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="609" mass="67980" checksum="DB20AFD42B16EBBF" modified="2008-01-15" version="1">MTSAKGNIFDQYKCIEVYNALDDGQFAEAVYKANELLSAGPLPLASALKTLALFRLGHREEADREATKLLQGSVDLNVLSPLEYVLPRIGKTHQLADLYMAASNAHPKDDQLADGALVVLVKAEMFQRASQMLLKRFRSSKNAQDFWRYIQVAILYSQRVKPPGSKLTLDIALRLLNEQQLTAQSFTAETFSLYLNFFILLGESRLAQALEMLKLAPIQELVNKDLGIQFQVRECWKILDDKQSILSDCRTRIMKGDRNWAVISLFTATMAELAHGSMDASDVQVILDAAKQDGWKDRGSFLGVLELCRLSAELDLATPAGLDYPQLVLDYARQYASKLTCFDDLRPYFGSLNASHRDMLLECFSTREILTSEPLVYQRINAGKVSLLFDTIGCSFSVEELLKAHEESLQHVRLPSTEMQPGDDLALMAAYKALLSSPDTKGLVQAASIASSACQKSEHAYKLRIFLIRVLLRLGCPRMAMNHLHTLKLKAVQLDTVTHVALDRNASFGGSHAADVTNEWESNIKGFYDLSSFEVPEAVGRAFLNGKFSQVSDLCEFHDCIEGSYARIILLLDIIQGKLVTENLAENERAFAVELVHDFKRKIEGTHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY11</accession>
    <name>A8PY11_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1568</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731385.1">
        <property type="nucleotide sequence ID" value="XM_001731333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY11"/>
    <dbReference type="FunCoup" id="A8PY11">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY11"/>
    <dbReference type="GeneID" id="5855692"/>
    <dbReference type="KEGG" id="mgl:MGL_1568"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1568"/>
    <dbReference type="InParanoid" id="A8PY11"/>
    <dbReference type="OMA" id="SGFACAN"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="9">
        <location>
            <begin position="93"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="177" mass="19569" checksum="82109C3EB9EE7408" modified="2008-01-15" version="1">MHPSDHVSFASVHGREPFQTHRVPHPYDPSTSIDQMMWPDHCVAGTRGSQMHARIQAALDARCTSGVPVHYVHKGTDKRIDSYSGFACANYVQFTELASILHRAREPISTVVVCGLATDYCVCHTAVDAAKFGFRTLVLEDCVRGVDASSTAHAYKVMQQYQVAVVPVCTSWKLYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY53</accession>
    <name>A8PY53_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731410.1">
        <property type="nucleotide sequence ID" value="XM_001731358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY53"/>
    <dbReference type="STRING" id="425265.A8PY53"/>
    <dbReference type="GeneID" id="5855717"/>
    <dbReference type="KEGG" id="mgl:MGL_1593"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1593"/>
    <dbReference type="InParanoid" id="A8PY53"/>
    <dbReference type="OMA" id="DMWLLYP"/>
    <dbReference type="OrthoDB" id="6244550at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924:SF2">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="43"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="988" mass="105824" checksum="FD3E276E2FF716D0" modified="2008-01-15" version="1">MVGDSGGRVHDSPSTQRTPLQQQQPQPQPQPQGSPSNANLERRRTNPLGELIATETRYVQELSIAIRRIAAAWNPNRLPPKELDLMFRSLEVLYRTNSEFLRSLQEIGPNPASPKGLGNLLMHWVDNLQAPYANYLAVYMPLLDTSPSILSNKDLHHVLAQVSRELPRSAGPDSAWTLDAFFALPIERLRFYKKLYGRLLRNTQPGRSDHTMLQSANQTLNELIDTAVRRQSISRPGAVLTPLALPRSTEPVERVLSPPVSHPASSRAQGSPPSAPIAQPALTATTTTATPSVVTARGEAPGELTGPVAKSTAMEPNTSSGSLPVLGQALVPPNDTLAPTATASKYPPSITSSLESQSLEEIQSRIDSTCTIDIFSMEPKSCRLQMAPPGLTFQRKLRLTDGLRLEIVPANGPVRIIERARLILLTDLILVAEDRASQTLPSGTQDIRLIFPPLSGRFVDTHDDKRPQDPSIRLSIMNRVNLIMHLGRIDRKAIWLHELRACKLFGADKSASEAPRLPGNAPVPPMTNALVRPSAGTPNAPAPPFASPSPLTNEVGGGRPPPFAPNQLGIYSRPPAPLAGPLSTPVGTGKGLSSGTTVPGSGAARPMSPVSSPAPLAPPALGPIPSSTPAPGTSHAIMSPSGAASIRTNAPRPGGMNPAATTSGPNAPFASGAPAPPIMPDVQSPVPLADEDSGLSSPPLTPEPPTRANSLASHESFPRIGRRVDSPEPLVSQRLEDTRPGVRSPVVQGPAMSFGSASEHALGGFQRTDTSLFSADRRPSNAPTPSLRGMRSMTLPTTASNASAPSISSPSSPSRSVSQSRLREAAGSAVLPSQMLREKPQRRSSEWIHQHDEEDKAADADALQFSKFHEAQSFNICAQMRCKVYLKQSYAQWRALGSARLRLYRLRPSNTNQLVVENEKKVMISSIVLPMAVQRFGKTGLAIELSDMGRLTGVVYMFHMRSEESANGLYEQLLSGSSRSALSSPQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY80</accession>
    <name>A8PY80_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731426.1">
        <property type="nucleotide sequence ID" value="XM_001731374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY80"/>
    <dbReference type="STRING" id="425265.A8PY80"/>
    <dbReference type="GeneID" id="5855733"/>
    <dbReference type="KEGG" id="mgl:MGL_1609"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1609"/>
    <dbReference type="InParanoid" id="A8PY80"/>
    <dbReference type="OMA" id="GSSHWGF"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727922" evidence="7">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="278" mass="31746" checksum="D8766534A6979888" modified="2008-01-15" version="1">MSWAVVAVAWWLMVWMRPVHASQFACDKIMVNSGAHVLDLSPEFEKGPITAGWSRATPPSTTISNVTMDLCKPLPQLKQLDKEDQCPYPTNACMTVTSRRGKQDQIVQVVPVAGTGEGLRLLDTASNPDETLDVELQFQGRVWAEREQTMYLRVLCGAYSQLEIKAYDPDAGELQLQWNTPQACFNARRKPAQKQRRTGYFSLWWFMIFVALMYLGVGMWYNHHQYGATGWDLLPHRDMWRELPYVASDFWRHVSRTWQGSTSVGGNMATGRYGYEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYU3</accession>
    <name>A8PYU3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731542.1">
        <property type="nucleotide sequence ID" value="XM_001731490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYU3"/>
    <dbReference type="STRING" id="425265.A8PYU3"/>
    <dbReference type="GeneID" id="5855849"/>
    <dbReference type="KEGG" id="mgl:MGL_1725"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1725"/>
    <dbReference type="InParanoid" id="A8PYU3"/>
    <dbReference type="OMA" id="LETREIM"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="63224" checksum="E02D7627D4F1FBEB" modified="2008-01-15" version="1">MSDFEFSMINASISLIELLQREVRHPHARQLPDIYKIIARTYSRGIHTPLELVLTTLNTMATMDRTATTEWLVAPKDSHVRMAPIVIVIDVLERMLCDTYALCAYTYERASEGRVRRACVEWLGELARQQLATLQYCRSLGTPHSLYYEECEAWRSTAAHWYGIAARDVPDDGRWYAALGELCERDVLLSMYYYCKSLQVVHPRLETREIMLELVHRKVQQTRVAIRSPAHDLFAHLLGLLLMRVELDTFEGVLNRLAHHLTQDPCPLLETEWCMISVCTAAAILEFGREDAWVPARHLGAFHIPSDARPLSDSCATLLPDLYKQIQLATQTHVSQPRDVASILAACDNYNMPMPLSCALALAITLVDMATRRLSLALNDPAAHINAPGMFLTVMLSFLYVLTLRTDEPHISAVCEVLRDRLPWSQLASYACGDVFGSRPTDEAALLPPAQADLPEDWCLRGILWNVCTPKTSPVLSQTEGMHAFSFVSESNMLADLGAISRHFATLTTNTYRAAYAQDPELKRLLQVRHARTSLLTARLYGYTFQHKRDPHDSGSSLSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ58</accession>
    <name>A8PZ58_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730891.1">
        <property type="nucleotide sequence ID" value="XM_001730839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ58"/>
    <dbReference type="STRING" id="425265.A8PZ58"/>
    <dbReference type="GeneID" id="5855198"/>
    <dbReference type="KEGG" id="mgl:MGL_1890"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1890"/>
    <dbReference type="InParanoid" id="A8PZ58"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="136" mass="15500" checksum="6F57B93934F3E738" modified="2008-01-15" version="1">MADLEELSYMDGYRGGYEQGQQVGLIEGRLFGGEKGFELWTELGYYKGVISVFKHILESQLSTKLHEVHELESVDLKAKKQWQQLASLEALWNQIPQQNDSNNAAANEICHNDEDVFDLVNLISSVLQDSWLIQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZE3</accession>
    <name>A8PZE3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1912</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730913.1">
        <property type="nucleotide sequence ID" value="XM_001730861.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PZE3">
        <property type="interactions" value="582"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZE3"/>
    <dbReference type="GeneID" id="5855220"/>
    <dbReference type="KEGG" id="mgl:MGL_1912"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1912"/>
    <dbReference type="InParanoid" id="A8PZE3"/>
    <dbReference type="OMA" id="VECHYQL"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="12">
        <location>
            <begin position="329"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="11">
        <location>
            <begin position="520"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="10">
        <location>
            <begin position="704"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="9">
        <location>
            <begin position="1046"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="13">
        <location>
            <begin position="1268"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="8">
        <location>
            <begin position="1608"/>
            <end position="1803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1869" mass="206117" checksum="B44C14C2F7EF0277" modified="2008-01-15" version="1">MFHSLQGTWLSVPSDVNGTVLFDKLSEHIAESAAVDVSQSHMAQFLVSLLRDEDPNQPPVLDRSQRVQLVARLCDTFQDTVAQALSSVVPQLPFKPLGEQLLDLGEKPITADNLGLLIKHCAFTEPSNADVSALLGQLLSASTLRLATNFALLPQALAAYKSTLDWQAIVRGLDELDPLVLVPSDQLGVALCDWIHGTPDPRTTFSALWGVWTHRSRQLQILYSLLLSNATHFSMKDVTARQIVVPSDFQDAPGPVQMQAQAASESVWNSLDLIETLMDLASSASGAEDSAEVGRPVTAILERAIQMNAECVLLGLVLLPSTTNVVHTELVTKLLAMFLAGHPAHQLVFRHLWRTQPVLLMDAFKRLYVESPLHMTRIVDVAQELGMVSHLVSQRPLAFALDAAALAARRDVLPLESWLEELISSTAPDAQPITATLDYLDSKIREDLLRRDPQAEPTFVPLHVQQVATILRVLRGFGDAMTPKEIEHFKIARNMCLQLHPRLMTLTPGPNAPEPGLSVTTFTKDVHREADSWYRQMYEEKVSVDDIIALLRRCKHSDDAHEQQLFACMVHTLFDEHRWFELYYPPRELLMTAVVFGALIQYRLIEAIPLGIAIRYVVDALESPPESTFFHFGLQALLRFQKRLPEWPQFCQVLLSLPTLTQSHPEMIATVNQALIAAKSGKIPPAEDAVFPAIEPDGLPADSQRKPDESESDKLLFLINNMSLANVDEKLASAREVVVPEILHWLARYLVLERVSLEPNNHDLYLVFLRGLEQPRVFKYTLHETLAKLKNLLEAEKTMQSTSERTILKNLASWLGLTTLAQQRPILHRQIAFKDLLLQGYEAGRLIVAIPFVCKVLEHCANSRVFQPPNPWLMAVLRLLVELYQYANLKLNLKFEIEVLCKSLRVDLQKLEPTSLLPGRRPELPMHVAPALAPGMTAAAGVAAPGSAAAAAAAAAAAAASNVPGSAALAAGTPTNAAAAAAAAAAAAGGAAGPSAEYGNLVPGMEQLSVSEPVAYHDMFVTMLQNMAQYIVISPQIVPYANSAAWKRVMYVALERAIQEIITPVVERSVTIASISTRELVSKDFAMEPDEQKLRSAAHHMVQNMAGSLALVTCKEPLRLSILTHARTLFTAGGVSEQALPEQALLMLVQDNLDLACVVIEKTAMEKALAKVDEGLASAYLTRRDFKMHGRGALFWDGTALSHYSTTLPDMLRIGPPGLQPAQLRVYEQLAMAPTVPRPEDELETDDLPGILTPAQALERFLLMAAELERLFAEVTESQTTTLATLPSTHFVRQVLPHLMELVLQSSHRDETVLLIAQKTVQLLYKTGTDLAREVWVAVLEQLCEQSPKVAREVTAWLMYAEDERKFHVPVTLALVRANMVGLVEQDQQLAKLLVRSQCRPSVVDYSAQLVRQCLQEGLATRAQFSTLLSALAQAVQYGRGTPAAQALLDELDDLARSESAMPLREQLAYSFASWVRVFQQSSNPEKAFIEYVTQLQSQNVLKGEEVSSLFFRMCTEVCVGHYAKQHAVGGTRASGIFSPIDTFAQLIVYLIKYHADPSGTNYEQAKVHYLSKILSIIVLVLAQSHEQMGAHFQQRPYFRLFSSMLHGLHAAESSLQGAYPGALLAIANALHTLQPAFFPGFAFSWIALISHRLLLPQLLSRTLPLSVAGTAATTTASSSNAAATAAGPVAFHRLLLAHLRFLAPFLRQGALHDTTRLLYTSTLRLLLVLLHDFPEYLAEHHQSLCDAIPPVCIQMRNLVLCAYPRTVRMPDPFSTSLRLVTWPDPKFMPAMQYDARAVLLRSAAAPMLLERLDELVRGTPWPAGTGHHVADCFCLAQPHRHALQRSVDQCGRVVHGTHRIAGHKPCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZQ5</accession>
    <name>A8PZQ5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730941.1">
        <property type="nucleotide sequence ID" value="XM_001730889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZQ5"/>
    <dbReference type="STRING" id="425265.A8PZQ5"/>
    <dbReference type="GeneID" id="5855248"/>
    <dbReference type="KEGG" id="mgl:MGL_1940"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1940"/>
    <dbReference type="InParanoid" id="A8PZQ5"/>
    <dbReference type="OMA" id="QMCCNAY"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="152"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="247"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="251"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="502" mass="56206" checksum="32FFABE131ED03A9" modified="2008-01-15" version="1">MSQTLAGLSKLYSQSNRHSFYGWPLGNNQSTGPASTVTSASKRSSTMPVDTSSSTTVSMPPATAVPSTTSRPRHRYSTFVPYNAANYTHAKSSTDAKKMRLQLPSNNILFEIEYQQENLEYMHVMEKQTMANVELMNVQPELHWFMRPYLVDFLIEIHQSFRLRPETLYLTMNLVDRYVSKRIVYKRHYQLVGCAALLIAAKFEDAKDRVPTVQELSQMCCNAYDPSAFTQMEGHVLSTLAWQLGHPTAEAWLRYEYSCAPPSNPSTHNVARFLLEVTLFHESFLTVVPSALAAGAMMLARHICRDPRPHPHQLGAAASAVMGQIHNHIVENLNDLSMILIKKYSYSYYTEASSIVVEWFRKHIEMKKAMEMTTSTPHMELCSSDDDIESQQSVDSAASIFSTPSRSINRDDDDDDSMPLTPLSLHTAQDPTIAGVKASVHSARLPQMNASSTNRPIHTTSNDKGSSANPSWMSLAQLRPVAKHTKSAARMDMDAIMSEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZR2</accession>
    <name>A8PZR2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730943.1">
        <property type="nucleotide sequence ID" value="XM_001730891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZR2"/>
    <dbReference type="FunCoup" id="A8PZR2">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZR2"/>
    <dbReference type="GeneID" id="5855250"/>
    <dbReference type="KEGG" id="mgl:MGL_1942"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1942"/>
    <dbReference type="InParanoid" id="A8PZR2"/>
    <dbReference type="OMA" id="GKNKSCK"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000018">
        <property type="entry name" value="Multiprotein bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="7">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="151" mass="16017" checksum="53F93D7081F9B2C1" modified="2008-01-15" version="1">MSAWDQTVVIGRKARPGGSSGGGGPRGPTALERAKQVGAVTANDRKTAAGHNKGHQGTDHQRIAKLDREDDVPPPSRVPPSVGKIIGQSRQAKSMTQKDLAVRINEKPSVIQEYESGKAIPHAQILAKMERILGVKLRGKDIGLPLGGPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q049</accession>
    <name>A8Q049_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730983.1">
        <property type="nucleotide sequence ID" value="XM_001730931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q049"/>
    <dbReference type="FunCoup" id="A8Q049">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q049"/>
    <dbReference type="GeneID" id="5855290"/>
    <dbReference type="KEGG" id="mgl:MGL_1982"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1982"/>
    <dbReference type="InParanoid" id="A8Q049"/>
    <dbReference type="OMA" id="RSKYWLG"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17055" checksum="B680F4A58A7B43F3" modified="2008-01-15" version="1">MVVRLRLARHGTRNNPFYHVVAIQNTKARDARPIEKLGEYDPVPRPLRSVLPNPVRQRLQDRPGYNGQVITPGISTQPRLEKRLEWNEDRIRYWLNTGAQPSKPVARLLDRAGLIPPEKRAMYKGLFHPPQPTVGNDLEGSTQEHRGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q059</accession>
    <name>A8Q059_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1986</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730987.1">
        <property type="nucleotide sequence ID" value="XM_001730935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q059"/>
    <dbReference type="FunCoup" id="A8Q059">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q059"/>
    <dbReference type="GeneID" id="5855294"/>
    <dbReference type="KEGG" id="mgl:MGL_1986"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1986"/>
    <dbReference type="InParanoid" id="A8Q059"/>
    <dbReference type="OMA" id="FHTTAER"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="375" mass="41727" checksum="CB6F29CF6CE34830" modified="2008-01-15" version="1">MEDEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNAPAFYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYSMPHAILRLDLAGRDLTEHLVKILMERGYPFTTTAEREIVRDIKEKLCYVALDFEQEMLTAAQSSALEKSYELPDGQVITIGNERFRCPEALFQPSFLGLEAAGIHETTYNSIMKCDLDIRKDLYGNIVMSGGSTMYPGISDRMQKEITALAPSSMKVKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0S0</accession>
    <name>A8Q0S0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731074.1">
        <property type="nucleotide sequence ID" value="XM_001731022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0S0"/>
    <dbReference type="FunCoup" id="A8Q0S0">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="GeneID" id="5855381"/>
    <dbReference type="KEGG" id="mgl:MGL_2073"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2073"/>
    <dbReference type="InParanoid" id="A8Q0S0"/>
    <dbReference type="OMA" id="TFALICH"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="71314" checksum="3AE34F3CC2186293" modified="2008-01-15" version="1">MGEDVHVARLRQMQDVPHIPHMNTSIPGPDYVLPEVTEEEEQALEEDPVLHAHDEDELAWLRRLPWWHKPRPLWLLPVLFLFALSAGMMLASRLELFLALICKAMHVDDIELHESSSLSLASLPSFIHPVHAPSAVCRRSVQAQSRLSIIQLELVVIVGVFSMLTTSFWSQLSDRKGRTRVLAIALSGSLCNDAVSLCVSLVSLSNIPLGWWILVWGSVMEGVLGASGTVTAMAQSYLTDVTSSGTRSRLYALMTGVLFAGVAIGPTIGGFVTKYTGSLSLTILLASLVRLSIFAISPMIPESLSPAVRENATQEHDSMLRFERDRHGQMVAFWAGVKKAIMTPLESLSFLLPRRKSSYALVPNESFPTLSSTEQRVTSSEWDTNLLLLSAAYAVEMTCIAIVPVKIQYVQLVFGWSSSAVGLFVSFAAVSRMLTLTVLVPLLVKLLHRMPKSIVLPQDAAFVSASDAYEVLDEHGRLLYASPPALWTQAEQQLEKRWMARAKQLQLIHDSHMDMYIAVVSAFITVIASIIMAHSRTSGLFMFGTFAVSLGAGIGSAVSSLGMAVIPRADGAGRLFGAWAILSTLSSAIVGPFMFSMVFSRSASTTPSLVFYLVGALQLLTLSLLYFVRLSSSDTLEGLAPRPHAPLRRNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q130</accession>
    <name>A8Q130_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-hydroxyacid dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731119.1">
        <property type="nucleotide sequence ID" value="XM_001731067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q130"/>
    <dbReference type="FunCoup" id="A8Q130">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q130"/>
    <dbReference type="GeneID" id="5855426"/>
    <dbReference type="KEGG" id="mgl:MGL_2118"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2118"/>
    <dbReference type="InParanoid" id="A8Q130"/>
    <dbReference type="OMA" id="VMDAAPS"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF289">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="30"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="148"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41049" checksum="7121ACF52883B341" modified="2008-01-15" version="1">MVLTLRTARRSLVSCLKYARASYSTRPQVLLMDEVQLAKKDLERLTAHTELLYNHTKSREELIQAFAPGGPFANVRGMYRHFGGARSIRISGRFDPELVRALPDSLKFIVHNGSGYDQLDIPALTERGIQVANVPTVVNEATADTALFLLLGALRQFPRAIGQMQAGKFNSQFSFRDASDPEGLTLGIVGAGGIGRTLARKAAHALGMHIVYHNRTRLSEELEMQGMPEGKRMEYALSLDSLLGQSDVVSLHCPLTPQTHHLIGAAQLARMPSHAILINTARGPIVDEAALVDALDRGVIAGAGLDVYEKEPEIHPGLMRLSTSKALLLPHVGTLTLQTQTDMEAVCLRNLEHGLQTGRLLYTVKEQEGLGLCAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q193</accession>
    <name>A8Q193_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730754.1">
        <property type="nucleotide sequence ID" value="XM_001730702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q193"/>
    <dbReference type="FunCoup" id="A8Q193">
        <property type="interactions" value="725"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q193"/>
    <dbReference type="GeneID" id="5855061"/>
    <dbReference type="KEGG" id="mgl:MGL_1753"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1753"/>
    <dbReference type="InParanoid" id="A8Q193"/>
    <dbReference type="OMA" id="CFVPRGV"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="426"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="571" mass="62680" checksum="3FD05D20BD018E06" modified="2008-01-15" version="1">MISSAAWIARGIAARHPEKHQLDDAELERISKLTNTELGEAERQLAQAQAAADDGWEDVDEDEDEDDDDNEDEAMDEDDAGGDPNDLSRYKLDDYDKEPAQNVAMGALSGIRGVQFFRSNDDDPYLTMKEDPADEAEEREQLEVLPTDNMLLTAKTEDDVSMIEAYVYSSQDQNLYVHHDLLLPSFPLHLEWLDYTPAPMLDESQQQGQGGRAAGAPGNFVAVGTMDPEIEIWNMDTIECMYPDSVLGRKDLTAALDAPSGTGKKKRRVPKARVPNDSYHVDAVLSLSWNRRVRNLLASASADTTVKMWDLSRPMSGTSSSALRSFSGHTDKVQSVAWQVGAPGMASGTENPAVLLSGSYDKTIRVYDTRMPEQAMIARIGADVEAVRWNGWKDHAFLVALESGTVHGFDVRALSPQGTDAALYTLVAHDGACTSLDISPHIPGCLLTAGTDRQVKLWSIDDEDADKPRSINLVTARDLGIGKIFTTSFSPNDPLTVAAAGSGGKLHIWDTLANPGMRRTFGDRLRRLDQYAARHAVDLSHVQLDDRAERSADVEVDDDAESDEDDDAEMQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1F0</accession>
    <name>PESC_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NOP7</name>
        <name type="ORF">MGL_1778</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730779.1">
        <property type="nucleotide sequence ID" value="XM_001730727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1F0"/>
    <dbReference type="SMR" id="A8Q1F0"/>
    <dbReference type="FunCoup" id="A8Q1F0">
        <property type="interactions" value="675"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1F0"/>
    <dbReference type="GeneID" id="5855086"/>
    <dbReference type="KEGG" id="mgl:MGL_1778"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1778"/>
    <dbReference type="InParanoid" id="A8Q1F0"/>
    <dbReference type="OMA" id="QKVTWIV"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000370496" description="Pescadillo homolog">
        <location>
            <begin position="1"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="387"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="684" mass="76672" checksum="72AA7DE257EE0061" modified="2008-01-15" version="1">MARIKKRGESGAAKNYITRNQSLKKLQITLAEFRRLCILKGIFPRQPRHVKRANKGSTAPTTFYYTKDIAYLQHEPVLQAFRDHKAFAKKVNRAIARREWHAAKNLDENRPKYRLDHIIKERYPTFVDSLRDLDDALSTLFLFANIPSQKSMAPEITAHCARLCAEWQLYVMRTHCLSKVFLSIKGIYFQAVVHGQEITWLVPYMFTQTIPTDVDFRVMMTFLELYQTLMGFVLFKLYTDENLVYPPKLDESLDNQGAGFGSLMLMAADADVLTGKHSLRPMDDAAAAEASSNAITRKDGKKLSTRDVKRQIAQLTRSEDKAEHEPEDDESMPALDATMQDQDSDEEADDEAGAADAFVAHASKTQGAGADQLTTLRDLQKQAGEDPLPMLFSRYVFYISREVPRTVFEFILRSFGASPSNVGWDPVAGAGSQVAVDDERVTHHILDRPVDGMSLDHAGHRVYIQPQWVVDCVNARQILPTDPYRPGQTLPPHLSPFVDDREVARKGGYVPEEAREKLGLEAEYVGGADEDEDEDEDEDEDEDKAGSGRGDDKNVAAREQDAVEKHDKTPARPALEALLADPTGAGLLEAAELEAEATGGEDALLDLRAKHAASLKSHKKKKRTSTTQSPQLSEEAEARDMAKTLLSNKQRKLYTRMGQATGKKKEEKMRLEAKKRALSKNKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1H0</accession>
    <name>A8Q1H0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730787.1">
        <property type="nucleotide sequence ID" value="XM_001730735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1H0"/>
    <dbReference type="FunCoup" id="A8Q1H0">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1H0"/>
    <dbReference type="GeneID" id="5855094"/>
    <dbReference type="KEGG" id="mgl:MGL_1786"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1786"/>
    <dbReference type="InParanoid" id="A8Q1H0"/>
    <dbReference type="OMA" id="AFEMREN"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="140" mass="15711" checksum="78E72BB68FF65D37" modified="2008-01-15" version="1">MFFGTALRSVPRSLTTRAFSSTPASALSRVTLIGRLVAPPEVRESRHGKEYLRYTLATNDLPGPPNEDGTPAPPTSSFHSIFAFGENTVSRLRDVPKGTLMYVEGDFRVVRTPGDDTMPPQEQWLVQHRNYRVLMRPRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1K2</accession>
    <name>A8Q1K2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730802.1">
        <property type="nucleotide sequence ID" value="XM_001730750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1K2"/>
    <dbReference type="FunCoup" id="A8Q1K2">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1K2"/>
    <dbReference type="GeneID" id="5855109"/>
    <dbReference type="KEGG" id="mgl:MGL_1801"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1801"/>
    <dbReference type="InParanoid" id="A8Q1K2"/>
    <dbReference type="OMA" id="WITQIRK"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="148" mass="16483" checksum="CDF61694518E5D90" modified="2008-01-15" version="1">MFRLAAARGLPVVERSVARVPAYVQSSRCESTVADHTLSDTPQASMPKSIRYPYFVSRVGMAGTSLPVYTDIRHGGSKWITQIRKVEGDVSALCHDLFDDMGWGNPYDKCNPNARMLLRVTNNAGPKTVHLRSNVSREVKAWLESRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2K9</accession>
    <name>A8Q2K9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730410.1">
        <property type="nucleotide sequence ID" value="XM_001730358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2K9"/>
    <dbReference type="FunCoup" id="A8Q2K9">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2K9"/>
    <dbReference type="GeneID" id="5854712"/>
    <dbReference type="KEGG" id="mgl:MGL_2206"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2206"/>
    <dbReference type="InParanoid" id="A8Q2K9"/>
    <dbReference type="OMA" id="MFIRTDL"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="123" mass="14427" checksum="9DA96E23634ABD79" modified="2008-01-15" version="1">MVSSQRELSTVQAQMKGRSREARVQELTMEQLQKLGPETRLYKAIGKMYDISPLWCGIFFVLICRFMEQSYQDIMNEAQKRRDDALEENKMLEKKVTFYEKEANEAQTHLQDLVKSLENANTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q349</accession>
    <name>A8Q349_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730515.1">
        <property type="nucleotide sequence ID" value="XM_001730463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q349"/>
    <dbReference type="FunCoup" id="A8Q349">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q349"/>
    <dbReference type="GeneID" id="5854822"/>
    <dbReference type="KEGG" id="mgl:MGL_2311"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2311"/>
    <dbReference type="InParanoid" id="A8Q349"/>
    <dbReference type="OMA" id="YTQCPLN"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="50497" checksum="D839739A57FC0EC9" modified="2008-01-15" version="1">MLDIILRRPQRLLVLLAIVMVIIVISSYGSMSSWNAEKFQNQIKHIPKFFGNHSCPPVPVRDAFADSTKFMSNVTSIDDLGRYATKDHVGNYFPPEFNPADINKTPRAKAAFITLIRNSELDDMRQSMMDVEFRFNRKYNYPWVFLNNKPFTAEFKQGVKQMTRAPVYFGILPEEHWSYPSWIDQNKAAAARAKMESEGIIYGESESYRHMCRFQSGFFFEHPLTYQLGLEYYWRVEPGVHLMCDIDFDPFLFMQMNNKAYSFTLTLPEYDATIPTLWDETMKFMKRHPEYLAHDSAQRFITDQDGLEGSRYNLCHFWSNFEIGDLRFFRGKQYKEYFDHLDKAGGFFYERWGDAPVHSIAAALFLNRSQIYQFEEIGYYHPPWGHCPANRKKYHDNGKCSCNPEDSFDRDGYSCMPKWWSVSVEGEPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q355</accession>
    <name>A8Q355_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_2315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730519.1">
        <property type="nucleotide sequence ID" value="XM_001730467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q355"/>
    <dbReference type="STRING" id="425265.A8Q355"/>
    <dbReference type="GeneID" id="5854826"/>
    <dbReference type="KEGG" id="mgl:MGL_2315"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2315"/>
    <dbReference type="InParanoid" id="A8Q355"/>
    <dbReference type="OMA" id="AVITFWW"/>
    <dbReference type="OrthoDB" id="15595at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018852">
        <property type="entry name" value="DUF2456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10445">
        <property type="entry name" value="DUF2456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="268" mass="30516" checksum="85C64A62D2A54C19" modified="2008-01-15" version="1">MHTFGAGILSGAANFGVACAMYRTTNKPIKMWPLNENTLAGDMGVTVVIQQIITYIVTSNLCNFDLRHGTRSLTRPWPPMMHFPSTSMPTGSWFGVKMPSVVQAEGHLLYMGNAENKSRFTQFCLWFLRATCTGSERNIIFERGLTVRHRFERLLWTALQGGWWAVITFWWYWPIAIAITQPLYGDDDLRGTWTPTFIKLLFGGIMGLITNPIMAMMTLGAECHVHRFYPDMELWQETEPALPMTSGNSFDDQIQSFDEVFTDFDATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3D4</accession>
    <name>A8Q3D4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2366</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730570.1">
        <property type="nucleotide sequence ID" value="XM_001730518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3D4"/>
    <dbReference type="FunCoup" id="A8Q3D4">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3D4"/>
    <dbReference type="GeneID" id="5854877"/>
    <dbReference type="KEGG" id="mgl:MGL_2366"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2366"/>
    <dbReference type="InParanoid" id="A8Q3D4"/>
    <dbReference type="OMA" id="VQENAMK"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="370"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="479" mass="53617" checksum="BCC1246050A027C2" modified="2008-01-15" version="1">MDSWQSPLSSRYASKEMSNLFSNATRFGTWRQLWLNLAIAEKELGLPIPDEAIEQMRAHLKLDEEQMRLAAEEEKRRRHDVMAHVHVFGLMAPAAAPFIHLGATSCYVTDNADLIFLRKGLDLLLPKLAVVIQRLATFAEKHRALPTLGFTHMQPAQLTTVGKRATLWIQDLLWDLRNIQRARDDLGFRGVKGTTGTQASFLQLFDGDHDKVEALDERVTQLFEFPYALPVTGQTYSRKIDIDVLSSLSSFAASALKIATDIRLLCHLKEVEEPFEKDQIGSSAMAYKRNPMRSERICGLARWLGNTLNSARETAGGQWMERTLDDSANRRLTIPESFLTADVILTILQNVSEGLVVYPAIIARHIAAELPFMATENIIMAMVRSGGDRQDCHERIRVLSHQAARVVKEEGGENDLIERVKGDPYFAPISDRLDALLDPASFTGRAPQQVDAFLTKWVKPALEPYAAQLASSGRAELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3F1</accession>
    <name>A8Q3F1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2379</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730583.1">
        <property type="nucleotide sequence ID" value="XM_001730531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3F1"/>
    <dbReference type="FunCoup" id="A8Q3F1">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3F1"/>
    <dbReference type="GeneID" id="5854890"/>
    <dbReference type="KEGG" id="mgl:MGL_2379"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2379"/>
    <dbReference type="InParanoid" id="A8Q3F1"/>
    <dbReference type="OMA" id="HCANILI"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="5"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="298"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="533"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="794"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="824"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="859"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="876" mass="97241" checksum="C94C26EAB3B99B48" modified="2008-01-15" version="1">MMLSGLSDAQRTAVTSDASRPLQILAGPGSGKTRVLTTRVAWLVQGAPDRKPIPPSQCVVVTFTNKAAAEMRSRLQALIGEERTRMLILGTFHATCARFLRRWGERIGLSRQFTIADADDAKRIIKDICADFDADMASDDVRVKPETAIAAISRAKSRCMNAVQWRSMSKYPPGTAMHEEHTYVCRIYAEYESRLASHNALDFDDLLMYGVKLFREHPFLSLDHIEHVLVDEFQDTNAVQYELMCHMSAGNKCVSIVGDPDQSIYSWRHADVSHLERMRTDFPGVQRVLLEQNFRSTPSILDAALSVMQQDKLRIQKGLYTSHAQGAPVVLRAFHDADEEARYIALEILRHVQCTGGLLTFADISILLRFNAQSRPLEAALQRHGIPYRILGGLRFFDRAEIKDLLAYLVVTENPAYTPGVLRILNVPKRGIGTKSVQALLAAAQAEQVPLLTYLERVSPAAAYGMRPAVVKSVSQFVQTIQELRNAAENGSSVADLLHLVLKLTRYEEHLRPDPDFDSRWENVQELVSFASSIDLPPQSPPSHHGEPVRKRARVSENRPEDANEFSVHNIVDNVHADEEVATTPLSAFLESSALASDLGVQEGSPPAMVTISTCHAAKGLEWPVVFLPASEDGIYPFYRSTTPEERREERRLYYVAMTRAQTNLILSWSHRRLVMSEWSSRQLSPFLAPLVSKAHGGHVPLDKKPMSDESWSHVSPPFTHAWLGVTASILSRSPITLERLNELAEAFATSPTGQQYRRISAQIPSGTPSAPWPSTLPRTDSFTNAEVRKWPRLGTSTSREVNARPVSSARSLTPKPAGQGFVSSLHTLHSTSSSLGTSFRSPTLGSSTSAEPHSLRVGSKRPRTLGVARRPRTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3H9</accession>
    <name>A8Q3H9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730611.1">
        <property type="nucleotide sequence ID" value="XM_001730559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3H9"/>
    <dbReference type="STRING" id="425265.A8Q3H9"/>
    <dbReference type="GeneID" id="5854918"/>
    <dbReference type="KEGG" id="mgl:MGL_2407"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2407"/>
    <dbReference type="InParanoid" id="A8Q3H9"/>
    <dbReference type="OMA" id="KNCENEN"/>
    <dbReference type="OrthoDB" id="3030710at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727192" description="HMA domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="42775" checksum="1110C76C4FDA7363" modified="2008-01-15" version="1">MECLKLCISVVVVACPCALGLSTPTAVMVGTGVGAEHGILIKNAPSLEAACSVRHVIFDKTGTLTRGQLHVTERWDAPLSSSSSSSISVSRLLALVHAVESRSEHVLAHALVQHCEPHKTSRMVVQAFEAVQGAGVKAHVECDDELYDVIIGHAGLHPLGEQPTPMLAFAQHWESKGSSAVAKAIGVYPDDVHAGLSPNGKMTLLQQNRTPPSDTSNARVPQSMWERVAEALVPTQCHGLAMVGDGVNDSPALATADVGVAMSSGSDIAMGAASIVLMRNELMDVPIAFLLCRRIFWQIRLNFLWATTYNLIMVPLAMGLLLPWGIYLHPMMAGVAMACSSVSVVLSSLSLRLWKRPDISAGVPPSVAFTHASVSAGLARLWHTLWPTAPQEPAYTALQEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3W4</accession>
    <name>A8Q3W4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730092.1">
        <property type="nucleotide sequence ID" value="XM_001730040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3W4"/>
    <dbReference type="STRING" id="425265.A8Q3W4"/>
    <dbReference type="GeneID" id="5854394"/>
    <dbReference type="KEGG" id="mgl:MGL_2474"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2474"/>
    <dbReference type="InParanoid" id="A8Q3W4"/>
    <dbReference type="OMA" id="HARIVME"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="769"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="492"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="722"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="819"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="825"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="865" mass="94462" checksum="8D30E7CC87C15DBF" modified="2008-01-15" version="1">MHDPGFPEHHAPSKEEMDPVVLAEKDPLATQVWRMYAKQRDQLPNAARMENLTWRLMSLTLRRQREQHESVANSLDSSLSSKNTANAGFVATTPSSSAVSPATDTAKKTDSPTSVLPSSSLHAAPSCSEERESGVDVQRGRNKTVRTIGVSAMPFDVKPTNENSRFFQRSRSRSLSMMDLERSSSRRQCSRERHPADSPLMNGDPFGLGSQQDMMLDLGLRDPELLFNEVTNDILDMAGSTGSDLLLPANLLPPRPISGVENMSPLHSVSATQPSLTLPKQDMTVSRSSEESSAVFSESDKELAKKRLLNEFTMAAYKNLFDQSEPNAWRAVSDLEHHAHVVMEMSGKRINSLHLNQDRDDGFLSNKSMLDSVPGIDDYVGHKANQHPEYGFLPRLVRKTSFDHKVRERSESRGPRNRVSQLADKSNDAEQVQSRKRVRGGSPMPFGMSMPKTGDQRVASGLSREMPHSYSHGLMQYMPSVSFDFFMPPPGAESNTNHTDMPSSSLSSLPTRSASVTNENLPPMMQINPRLQTDSIAPASFAPTSMPASVHPSTPNLQSNFLNASFSGFAGATSSTPASSPSTPSATSNPAVSPSLLHVDPTQLLAQRTPASGSLGGNSASGMLSSQTLTDMDSSSMPSERIFSQTIQRPPIHSQQSVLFDQTNPNGTFFTSVFHPLSVVDPSSSFPGPMQNQYSPMQAGHQVPDSYFSVPCTALNTNLTRHVPMSSPEQPQPKSPNECMEQQQQQQHHQQSQLHATLSAENLGSASSPTSTTRCFNCHTSMTPLWRRDPDGNVLCNACGLFHRLHGVMRPLSLKTDVIKKRNRSGTSARDGTARGRTSASVRRSAVPPSSEMTSSDSLPPKSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4B9</accession>
    <name>A8Q4B9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730139.1">
        <property type="nucleotide sequence ID" value="XM_001730087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4B9"/>
    <dbReference type="FunCoup" id="A8Q4B9">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4B9"/>
    <dbReference type="GeneID" id="5854446"/>
    <dbReference type="KEGG" id="mgl:MGL_2521"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2521"/>
    <dbReference type="InParanoid" id="A8Q4B9"/>
    <dbReference type="OMA" id="RVMAMEF"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728071" description="ABC1 atypical kinase-like domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="247"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="738" mass="83501" checksum="552B17232C063679" modified="2008-01-15" version="1">MRPMLCMVGGLRLRAITCAKAAPCHGRGQIRLLATGSSDDKRPSTAKFRVRPTTPPPRYPPQKAPEPILFDEPAVPFPHRTANQHAAFRRGSRLLSYVLGVTLVLGGTVYVGWNKLSADAGTTMTSPSSPPSTSSFSSLESLYADLKKSVSDSSASQTAQFMILALKRSTTIIKAVALCVWDYRRVLNAKYASKEEEEESLRNCHLRSAQRLLVALQTNGGLYIKLGQHLSSVILLPPEWTTTMRPLQDQNEPTPLPELEVLFQHETGKTFDEAFSWLDEKPLGVASLAQVHRACDRETGQILAVKMLHPNVERFSDIDMRMVTILVNWVKRVFPQFAFDWLADEMNKNLPLELDFRHEAGNSLRAQKDFAQYKSTCVYFPKVPWVHKRVMAMEFVKGQRPDNLAFLAEHHIDRNRVSQELARIFSQMLYMHGFFHADPHGGNVLIRPRQPGSRSAENFEIVLLDHGLYFEIDEELRANYARFWLSLISRSSPKVTRERRKYARLVGNIDDDLYPVLESAITGRSGLEGSDNKNPTGVKGKQRKSSLLDLDSSSRLSDDEKDHIRKTVMEKEGLLVDVMALLRRVPRAMLMVLKINDLTRALDANLHTTHGSARPFIITARYCAMAARRDDKERLTARRRSEGISFGFVKSYLSSCWNYMYFYHGLMFLERFSDIKAYFGTWALYIRAMLSDGGFDTRAAHLAASGVFAQEEEQKKEREAGERAKLALKSDASSNNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Q8</accession>
    <name>A8Q4Q8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">XPG N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730227.1">
        <property type="nucleotide sequence ID" value="XM_001730175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Q8"/>
    <dbReference type="FunCoup" id="A8Q4Q8">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4Q8"/>
    <dbReference type="GeneID" id="5854532"/>
    <dbReference type="KEGG" id="mgl:MGL_2609"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2609"/>
    <dbReference type="InParanoid" id="A8Q4Q8"/>
    <dbReference type="OMA" id="RFYQTKV"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="5">
        <location>
            <begin position="325"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="4">
        <location>
            <begin position="503"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="85488" checksum="3B278B0E5A544567" modified="2008-01-15" version="1">MIRGLEGFLHDAHLLQEESLNVLKNTRLGIDLSYYLRQVLSAPESAEPLVTAIGGQPIALMSRIESDIRVLEQHRIKPVFVLHGLSPAKRTRPFSYEDRRPGLRKRAWESYEDDNVALATQLFASSNSLHLPDLYRSVLRMCRHHHIEYVVAPYQATGQLVLMERHSKQYVHAMYGPTELFAFDGVDKVILHLNLRHGKFQFASKLAMMRELQCNEAEFLDVALLVGMEYCSTFPALQDESTGLVHSAGAPDFRSVAQLVRQNRSGFVLCTQFADHPMVARSAYLDQFCHARAMIKYSVVLSPSSGSVIPLPLALFDRGIKLEIPSDLHEIFSFRLPEQVLLYLSRGLVSTSVLGSLLSGFVIESAPLDNGDSDEYHQFVRGYLTESPTSLRCVAIALVCAAMHPFWRQRKVSAVYWFQPHMDVPVPHDASATQKLLAQVDRWYVPASLLDAELRRQNSSTIDIPLCLNTATDAARAARTILPKDSSMRLEKKDELVANSLWRFLELRGFLNAEHTLTTYGRALHTAIQHVRVNDRLQEPLYLALELLRAGVLHANPYSESIYSGGPSFGTDEEKRRMLLAMRTLSLLPILFQAQPWDAPLSREMLVFNSFVKGLSRSLRSLVEMVTLTLLLRTETRQQRDDYLDISLSLPFQSDANTGMGILIKCYVDALYTLHNGMIQPEESMLPDIVEAKSTVVEMLVDTFENVRDVATELRRACRFWTALVAAVDVLASEQAIDASLHAEFHATDELLKPMWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4X1</accession>
    <name>A8Q4X1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_2662</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730280.1">
        <property type="nucleotide sequence ID" value="XM_001730228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4X1"/>
    <dbReference type="STRING" id="425265.A8Q4X1"/>
    <dbReference type="GeneID" id="5854585"/>
    <dbReference type="KEGG" id="mgl:MGL_2662"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2662"/>
    <dbReference type="InParanoid" id="A8Q4X1"/>
    <dbReference type="OMA" id="LHDIATH"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="72"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="137" mass="15929" checksum="BF31C11AECF04B18" modified="2008-01-15" version="1">MGLLTILQKNKWDVGGQRTLRPYWRNYFEKTDGIVWVVDSCDAVRMQDCRAELWALLGEERLAGASILILANKQDLPGALPPEEIRKLLSLHDIATHSWRIQSTSAYTGENLFDAFDWLLEDIRARLYYHHREDTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5P3</accession>
    <name>A8Q5P3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729815.1">
        <property type="nucleotide sequence ID" value="XM_001729763.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5P3"/>
    <dbReference type="GeneID" id="5854122"/>
    <dbReference type="KEGG" id="mgl:MGL_2801"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2801"/>
    <dbReference type="InParanoid" id="A8Q5P3"/>
    <dbReference type="OMA" id="FAFPVDI"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2437"/>
            <end position="2547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2438"/>
            <end position="2450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2452"/>
            <end position="2463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2473"/>
            <end position="2525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="2547" mass="277062" checksum="5EC0F9096E4822C8" modified="2008-01-15" version="1">MEKESWDGGFRRRLPAYDAGVGGASSPAGHMHQPGKPIGFLAARNTPYAKKVLSKRLLLFTLFGLPLIIIFNLFLICIPILWGVANHTLAVSVMHIYAANITQPSDQGFVLTMEGQVKKAGVFPAQLYFREPVYVTWNTVPTTDQPMRELTLGHFPLERIGVAAGHGRLKQLTMFNITDLAGFTEFTKYMIGTKEFTWRLTCNNVHIEAFNFLPTFKNLKLTKDVIFNGMDNFENVKIIDFKLPGADPQGGITFEALTQLENPSPFGIQLGILNLDLFAYDQLLGPGMSSMLNVTPGVNYVTLRGRLLPQTNNQSALSILGNIFTQYINYEITPTVAVGRNVTLPDGNGASWLAEGIKVLRINVPFQAPEPIHPIKSILIKRFNLTYGPHSNAYGPDASSDALSAELALPFGFPLRVISTTNEITIVDEKNNKPITTVNGVKSPAETDLNVVSTDQTEGTIYLTLNPSSMSLPEQSDEARREFEMFQKEFTFTKEDIKLFNGSSRSLSETPVGTVLLNGIKFSVESGLLGLQGLNQYPTLILGVDVVGGTRANINLNVNTSIYNPSNVNLGVGDTTLLMVYEIVVGSVTIPNMRLNIGNNTLQAMSKFNPNAGPQGLDMLNRYISGLDTHLNISGYEDSTHIASLKPAFSAVRVNTTLPGLKTKLVQSASLKVLESTGITDDVAQTQVSLDNPFTSPISITHIVSNVTSHGLFLASLDTDTQYDASGKGISKSPLMNLHINLFPPDLFALVRRYALNAGESVEQLDGIMKIGGYTYSETTDANTQPTGSSGNQRRYIEDKETGPETLEERERALVKRKQNMYTNFNIANFVDKAFTKAAVDLDIVSTASIGDYETKLSFVQSDVKLETDDSLHLLLPVLAKPIVQKIVDGAVLVVKRVTILNPQQKSFITRLIGSITNSGPFDATISFPDGLQVSWNNKVLGQIKMPDIKLEADEGAQLNLSADFAVADVDALTEFTKFLVTEPSFIWTIQGQNLAITALGITVKGVSISKNVILTGLNGLKNDVKVLDYDLPSNDPAGGIHLMAQSQVVNPAQVGIELSRFGISIWSNGTNLGPAYAQRQFTLAPLSETYLPLEGRLVHQSSDKDLKVLSQIFTDVVHGKEVPVEIHGEYAGPSDVTWLNAGIKALKVSAVLPAKHFNVIKGIDINQMTLMFTKQSAWAPLASTNNTVAPFYLPFGFPIDINRAGGRFIEQYQGADNAALNVPYSPAYTQVQARIMTLQFKNVKFAAFSNGHGKFSQFIADATKQSCVKFVLHGAANAKAETAAGYVTVSDIPFHVSTSLLGLQNLNARPAYVEDLDVAHGYPKYLLVTINAFLYNPSHLTVGTGDVSFNLFFQNHLIGSANINDLVIHPGLNKVPTNVHYSPQGAANTRAGQTMLENYVQGISSTTYIRGSKGTTDIASLKQALSGIELRVTIPPLKKLLITEDQLVIPKDIAQTSIAQAKFQLANPFTASINLLKVKAKASYKGIYLGVIDADLHKNPIRAPGHKTITSRMLPLKMDLEPKHLIRFIEQAASDTGTDLGPLTSEFNKVMAMRSTKTTIQPYPDSNPPNCHSGRQFDVFGAVFSLLKGLKVTLDIQSTVKLDDYQTNLNFKQEPVPTDTDDTALYLIGPVGAPIVQNIVDQAQLTFKAATASRLTNDGFHVALDGSLVNTGPFDAVIEFPEGVSVDWNGKDIAKVYLPPVCAYANEGVPNYKTQGELKITDQSGFTEFTKYILHNKQFKWTIHTNKLRVRALNIVFSDVKISKDVSFDAFNNLPGVAITSFDIPGETSNALKIVTGTTIPSPASLSIDLETANFKIFFMNRYQGPIHASNLFLKGHATTSAQLNGFITHKSGSTDTNVTGELFSGYLQAKNQTLSIQGDSVVTKENGNKPVTWLSNAFKTLTLKVILPGKIYDIVKSVKIIDLFVTMMNQRDTWAPLTGSNLTLATFANPFHFTLKPLKAGFSSVLVYNNKDAAILQVSLTRASAGTSHGPQEIQPLALSFNNRRLQAQDHDAFASMLSAIILTSRVDFIFKGSVNIVAQMVIGDIPINGIPFKNIHSSLAGFDDLTGFLKLKRVYPESSTPQYLDNRLFCTVFNPSNITIKTTGLSLPLFYKGTYFGRALLNDKTLIPGESNIDAIARYQPNIANDTVALEVIQKYLEPVEHQPEEIPYNFSVNIHGISNANPPLSPFASFNPGLERLTVDTSVSGIGTRALELVDAYIDILKLFAGPGFRPFVPLLLHFKDDLPMPLQFYSILDESYIADESHDQLPLIMFDTKNLKDCYIPAAKAPKVDPGRKICGFFSNSLLARGLLNSLEVIGKKIETFNQLVAQIGGKNGFTLPAVKFNEYYVPITIVLSIGDTVLFNITTATELIDHIGDAFKKLNKGQKGQVAQGMKGLDLDQIGKLVENGFKDMVCILEEFLPLDFLDLAGCKKKSTSSSSSSSGSVSKTFIGSQSGSNSGSYPGRSSKAQASPSNAASTAGPSSGAGNNNKNTNANTNRNKNNNDNNSNNSNNNNNDNNSDRAGGSGAQTSSKSHNGGLFGGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q679</accession>
    <name>A8Q679_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729889.1">
        <property type="nucleotide sequence ID" value="XM_001729837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q679"/>
    <dbReference type="FunCoup" id="A8Q679">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q679"/>
    <dbReference type="GeneID" id="5854196"/>
    <dbReference type="KEGG" id="mgl:MGL_2875"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2875"/>
    <dbReference type="InParanoid" id="A8Q679"/>
    <dbReference type="OMA" id="WECIEDY"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="201"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="308" mass="33525" checksum="9B7A47DB309D0E48" modified="2008-01-15" version="1">MILAEEFSRHPKARDSDFSTNSEERGVFHMTPRLASTEACIRGALVCQLAASHSSPLADAAELVSPYVDGIDLNCGCPQPWAYEERVGSYLLEEPELVADMIRTVKGRLGDAYCVSVKIRIDPDLRRTDTLVRNALHAGASFITIHGRTRHESSGSDPVHLDAVQFAVDCARTCGLQTARGTSPGDAWTWAEDGGAGGFAPCVVNGDIWSNEDAMAWRAHTGARGAMSARGLLANPALFAGEPHTPREAVRRFVDYAMKWSLPTSLLHRHLAYMLEDTMSSRAESIYFNTLASPASILDWLTNAGYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q681</accession>
    <name>A8Q681_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Steroid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729891.1">
        <property type="nucleotide sequence ID" value="XM_001729839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q681"/>
    <dbReference type="FunCoup" id="A8Q681">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q681"/>
    <dbReference type="GeneID" id="5854198"/>
    <dbReference type="KEGG" id="mgl:MGL_2877"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2877"/>
    <dbReference type="InParanoid" id="A8Q681"/>
    <dbReference type="OMA" id="AFNKAMH"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000232">
        <property type="entry name" value="Sterol 24-C-methyltransferase erg6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="7">
        <location>
            <begin position="48"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="345" mass="38750" checksum="AEC949DBC8D29F64" modified="2008-01-15" version="1">MSGTSSTELRNRQGIADYTKFWNADSTKDSEKDQAARLDQYSNVVNAYYDGATDLYEYGWGMNFHFARYYPGEAFYQALARHEHFLAHTMNLRPGMRVLDVGCGVGGPAREIARFAGVQIVGVNNNAYQVDRANRYTAKAELQDQLSFVKGDFMKLKEQFGENSFDAVYAIEATCHAPSWEGVYGEILSVLKPGGVFGLYEWCMTDSYDPSNPEHRKIAHGIELGDGIPEMRSIAQARTALKTVGFQIEYETDLADQGDKIPWYYPLEGDIRKVQTAWDLFTCWRMTWFGKLVTQSAVRALEFVGIAPKGTYDVGESLKVAADALVAGGRKKLFTPMMFFVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q696</accession>
    <name>A8Q696_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2892</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729906.1">
        <property type="nucleotide sequence ID" value="XM_001729854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q696"/>
    <dbReference type="FunCoup" id="A8Q696">
        <property type="interactions" value="594"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q696"/>
    <dbReference type="GeneID" id="5854213"/>
    <dbReference type="KEGG" id="mgl:MGL_2892"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2892"/>
    <dbReference type="InParanoid" id="A8Q696"/>
    <dbReference type="OMA" id="MAIRGIF"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725483" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="25"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="219" mass="24911" checksum="E7CBF2651FAC9D42" modified="2008-01-15" version="1">MWRVLAHSLFLVLALLLSLCDNAHAIKFELIASKNPKPLCIWNYALADTLAIISINVVPRDPKTENDQRIDVRVVDRTHHSVYLNKKGLQGETRLAINTHHNADLGVCLSNHGSRDHILSDVDLDVHLGGEAIDYNAIANQESLSGMETELRKLAAIADEILEEMEYLKQREMRMSSTQVSTHHRVHGFSWLLIFSVIGLGVWQVYHLHGFFKRKYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6C1</accession>
    <name>A8Q6C1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_2917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729931.1">
        <property type="nucleotide sequence ID" value="XM_001729879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6C1"/>
    <dbReference type="FunCoup" id="A8Q6C1">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6C1"/>
    <dbReference type="GeneID" id="5854238"/>
    <dbReference type="KEGG" id="mgl:MGL_2917"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2917"/>
    <dbReference type="InParanoid" id="A8Q6C1"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="203" mass="23644" checksum="54B841FFDA815029" modified="2008-01-15" version="1">MSMRQHRVYNKLLNELVAYSAQLPPVEHVSYRHRKETDSFYNEMSDTTGKNEHIRVTRDTSSQQIVPNGIVMKQRVADLNVYCPNHPYDYRISINTETPVEAPKDMNMPKFVREKDRLSYAQQNFQVDLTQVVMPDRPAEPLHELEIEVRDCAYLMQLGYEAQQTKAGGEHVWTKFEDHVLVLLNNIRLLIRNSSFGEPKAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6F3</accession>
    <name>A8Q6F3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2949</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729963.1">
        <property type="nucleotide sequence ID" value="XM_001729911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6F3"/>
    <dbReference type="FunCoup" id="A8Q6F3">
        <property type="interactions" value="781"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6F3"/>
    <dbReference type="GeneID" id="5854270"/>
    <dbReference type="KEGG" id="mgl:MGL_2949"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2949"/>
    <dbReference type="InParanoid" id="A8Q6F3"/>
    <dbReference type="OMA" id="EDHNAYI"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="411"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="500" mass="55779" checksum="BE1450DC62FBAD05" modified="2008-01-15" version="1">MKIKALTRSLDDHAPARLGDAAPVQRNLDPTMHPFEKPREYTRALNAAKLDRLFAKPFVSAFEGHIDGVYALAKHPKRLDIMASGSGDGEIRLWDVNHQRCTYTYPRAHAGIIQSLCISPLSFSGNASASKRMLSCSTDRTIKVWNADPVPEGYGEYAEYRPDVSDDEQDEDDDDGDVVSGARDANLFSMQPPKLAASEPLSVYQGRTAFHSLSHHAHLPRFASASSTVQVWDLNRGGGSDALMTMSMGVDAVHVVRYNQSETDVLASAGTDRGVTLYDMRSGKALHKVVLTMRANDLAWSPLEPTTFAVASEDYNMYTFDMRNMSSATQIYKGHVGAVMSVDWAPTGQSLVTGSYDRTVRLWDVGKGARSRDVYHTKRMQKVFSVAYTLDARFVLSGSDDGNVRLWKHGASDKLGIVSARERASREYAQALRKRWQSVGDVAKIERQRHVPKPIRSAQKLHHTMSEARRVKEDRRRKHTKRGTMKPKAARKSVVLEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6H0</accession>
    <name>A8Q6H0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2964</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729978.1">
        <property type="nucleotide sequence ID" value="XM_001729926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6H0"/>
    <dbReference type="STRING" id="425265.A8Q6H0"/>
    <dbReference type="GeneID" id="5854285"/>
    <dbReference type="KEGG" id="mgl:MGL_2964"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2964"/>
    <dbReference type="InParanoid" id="A8Q6H0"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="91" mass="10590" checksum="2EF37C82557D3683" modified="2008-01-15" version="1">MLIFATIGISAFGFWRLGLGNAERRELARERAWSRIYLAPLLLAEADRDAFRRDRAALLREKLLMKDVPDWEAGKSVYNTKRYTPNNFVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6H6</accession>
    <name>A8Q6H6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729983.1">
        <property type="nucleotide sequence ID" value="XM_001729931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6H6"/>
    <dbReference type="FunCoup" id="A8Q6H6">
        <property type="interactions" value="398"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6H6"/>
    <dbReference type="GeneID" id="5854290"/>
    <dbReference type="KEGG" id="mgl:MGL_2969"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2969"/>
    <dbReference type="InParanoid" id="A8Q6H6"/>
    <dbReference type="OMA" id="KGCQLAR"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="273" mass="30331" checksum="57A6C2212E2EA662" modified="2008-01-15" version="1">MTTPSREDSVYLAKLAEQAERYEEMVENMKRVASSNQELTVEERNLLSVAYKNVIGARRASWRIVSSIEQKEESKGNETQVSMIKVYREKIETELAQICEDILQVLDTHLIPSAASGESKVFYHKMKGDYHRYLAEFATGEKRKDSADKSLESYKAASDVAVTELPPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQETEKPAEGAAAPAPQAEAAAAPAAQGGESKGEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6V8</accession>
    <name>A8Q6V8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3064</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730078.1">
        <property type="nucleotide sequence ID" value="XM_001730026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6V8"/>
    <dbReference type="FunCoup" id="A8Q6V8">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6V8"/>
    <dbReference type="GeneID" id="5854385"/>
    <dbReference type="KEGG" id="mgl:MGL_3064"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3064"/>
    <dbReference type="InParanoid" id="A8Q6V8"/>
    <dbReference type="OMA" id="YKPQTPY"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="13">
        <location>
            <begin position="441"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="152"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="321"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="161"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="568" mass="61913" checksum="81D76921C35780CC" modified="2008-01-15" version="1">MERFKAAEKEMKTKAFSKEGLIAAARLGPEEKAKVEVSQWLTSMVDELSRQIEAAEAEIEQSLATTKKSKKAPAKDEHVSSMEHRNERRNWHISRLEILLRMLENSTLEVDQINSIKEDIQYFVECNNEYDFEEDEGIYDEFNLDDEEEAYGLKDADDTTADISASPPLSSTAAAPERLVASPTSGSAATPTASSSQPPEESSSKSMSAAKESKREESIPAPKFKEDKKVVSASKKTSASTAASAAASSTSTTMSSSNDGFARERSSISTSVSEPSHDSASPVPPAGSASPATVATPTPKVVTPAAALPPVRYATAAAAAVSTPSTTASSMPAVASGSGTEGDMSNTTSIDGKETVTGTVGSVHDGARPTEGSRPRAPGTTAFGTAAGAGGSGHGGTGDVRLPDTLSDLVTSFEWAKQKSMLRESNLAHAQHTLDTSFTGGVPEPMDSERPKYYTPKDPYPTPHYYPQAPAAIFDNPALYGKFDVDTLFYIFYYQQGTYHQYLAARELKKQSWRFHKQYLTWFQRHSEPQAITDEYEQGAYVYFDWEGSWCQRRKNDFRFEYRWLEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q770</accession>
    <name>A8Q770_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729765.1">
        <property type="nucleotide sequence ID" value="XM_001729713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q770"/>
    <dbReference type="STRING" id="425265.A8Q770"/>
    <dbReference type="GeneID" id="5854071"/>
    <dbReference type="KEGG" id="mgl:MGL_3309"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3309"/>
    <dbReference type="InParanoid" id="A8Q770"/>
    <dbReference type="OMA" id="FKGGSTC"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="500" mass="55198" checksum="C39C32844687FF9E" modified="2008-01-15" version="1">MYAASHASAKRLSTCLWTRRSVHNYVRARSGTGVHARIPLLAGVTFGAEMSRGDRAKQEDAMSVACVTLPCEQLRQNILLHVQSGATRDPWFGWTCDEAGGAELAAQVVWFGCFDGHGGPQVSQLLKEKLHYVFEAADPSMVQDTVQYTRSIGGYFGRFQGGAMERWVQPELLARPPPAARTQEKARTLSELAQFVHGKSSDDMVEAESTTSTSTSATSSTTSATSTARSVDLERYMALDDDIGPQGAGIPVRHTKRHDVSHMKQACMTMEERATLAWLMMDREVQENEEYLGAGSTASVLLLHSLDVPTQPWYSSEYLALTTIQLGDTRFVLCDAETGQAHPLTQLHHPDEPTELERLSRQGAGVVTDSFGEVRFMGTLANTRSFGDTQTKRYGMTAEPDVHTHILRGSSFAFVVGFSDGISGVMSDQEVVDECRGARHPQDAARRVMKYADDLGSDDNATVICVPLKGWDKRDTAHDHTCSLRNERRSTTDLYRNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7T9</accession>
    <name>A8Q7T9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729575.1">
        <property type="nucleotide sequence ID" value="XM_001729523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7T9"/>
    <dbReference type="FunCoup" id="A8Q7T9">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7T9"/>
    <dbReference type="GeneID" id="5853881"/>
    <dbReference type="KEGG" id="mgl:MGL_3119"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3119"/>
    <dbReference type="InParanoid" id="A8Q7T9"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="480" mass="52625" checksum="0340FCCDAE5AE316" modified="2008-01-15" version="1">MPRSTTRDVRGRLALVQRTSHASSSARDVTHGPEHAPTQGPGPTLASTNAREHGRRTHGGNHGSSRAGYSGRGDNVPTSMQIKHTRPTESLSSLQDTHTHPSDTLATLAVHKRKVADVRVWLTEALDGTPTLAKYRAEPEQSVTPFFSVVDRFSAFLQSVLRFAPLPLASRDSNRSWRARSTASVSLTEKSNDEQKRHRQRRIILVEDWPNLTHERTREGVHRALERFIHSAGQVPLVLIVSDTVPRADTDANANDTFSWRSRRAVQMNIRMAVPESVRMHPALTEIRFNPLTTRMILGALTAQAPSHIPRHVLNAIAEAAGGDIRSATNAVAMLKNVPPNNVCHESAAALGNESESALVLFHALGRVLYNKRAGDAGETLDAKTAAAGSMGDKMSLDICATSTEESSIPESSPPPPPWLVHQRPSLVNIETLWSHLPVDATTFQLYLHHNMLAFMDDTDEALLALEAMSFADTFCRKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q863</accession>
    <name>A8Q863_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729667.1">
        <property type="nucleotide sequence ID" value="XM_001729615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q863"/>
    <dbReference type="STRING" id="425265.A8Q863"/>
    <dbReference type="GeneID" id="5853973"/>
    <dbReference type="KEGG" id="mgl:MGL_3211"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3211"/>
    <dbReference type="InParanoid" id="A8Q863"/>
    <dbReference type="OMA" id="YEVNESF"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="83"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="420" mass="46654" checksum="61C6B196E1D55E45" modified="2008-01-15" version="1">MASYSTPQGPVAPAAPHLEAQAMRIPKSVSDQAMQEDRYYGHRQVSEAIERMIMALFSCSHDSMAATMDVQKTSKGTAPRLSHFVAYALYRTRLPMAVVYFALLLLKRLKTQYPVARGSSGHRLFISAFMLASKMLCDDAYNNKSWVIVSQNLFSLHEVNQMERELFMYLDLDLRASPEELASFASELEMYGTPHVTLEDLKRTRLSSSTLTSSPTISSSVSQSPGSKSVGTPTSAPRRKVHRRCLSLRPDYWTHTNSNFMPTARHYRSESNEWSASGMQRLSRSCARASLPSQRSVPSIPTVTAPGIHHTSSSSSTYAPRLDSSFSPSMPWSTFYSTANASTMSITTPNSMGSSLRPTPSTSLSELSLNSPNASMYSTMPASMYGHHGWDHAKHVPAYEVNESFRMQPLAQMMQQRDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8B2</accession>
    <name>A8Q8B2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729695.1">
        <property type="nucleotide sequence ID" value="XM_001729643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8B2"/>
    <dbReference type="GeneID" id="5854001"/>
    <dbReference type="KEGG" id="mgl:MGL_3239"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3239"/>
    <dbReference type="InParanoid" id="A8Q8B2"/>
    <dbReference type="OMA" id="IFCFDAD"/>
    <dbReference type="OrthoDB" id="2547149at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="46956" checksum="50D1BF53DB484E6D" modified="2008-01-15" version="1">MSHPMPAKGNEEASANVRVLWKGVVVLHDGTQLPGISIVTTMHPWAHLRGTSAEEEKPDSRVSHAPLEAEAELCLALEMVRHHPLRALVTNDLDRLDSDMEASGYIVLQVDDTEDMTEAYMEQLFCLQHAPSPTLRLLFEPSSRPTMPFSAMSAHNSVLELLVSPRERVDGQLDLVVGRPVPRARAPSARPDDPAPRIPVHRPKIPIRDDETPAAVLSPPSLSDARVGKRGQLYVSLPDVHHTRRPPTPGRRGEKRPPRHPVDKILTKTDLSYTSYKPTPQPRMGSPTWKPVVPYTPMTADESSAPMEHNASLEQTNRTLIKKLVKYQLSGRGMERENQDHAACFQTAYAGTSLVFRHELGRCPLDKQKVAHVVQAHLDMYVDPTQLALCVRKIPTRIHEMAQQDSLQDSVSLGPFTHPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8J9</accession>
    <name>A8Q8J9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Squalene synthase</fullName>
            <shortName evidence="5">SQS</shortName>
            <shortName evidence="5">SS</shortName>
            <ecNumber evidence="3 5">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="3 5"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729740.1">
        <property type="nucleotide sequence ID" value="XM_001729688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8J9"/>
    <dbReference type="FunCoup" id="A8Q8J9">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8J9"/>
    <dbReference type="GeneID" id="5854046"/>
    <dbReference type="KEGG" id="mgl:MGL_3284"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3284"/>
    <dbReference type="InParanoid" id="A8Q8J9"/>
    <dbReference type="OMA" id="GEACQLM"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000023">
        <property type="entry name" value="Squalene synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="392" mass="44513" checksum="14F29D22AC5D5D9E" modified="2008-01-15" version="1">MEYLKLAVAHPSELRSLITYNVWRDPVHDFKRNPKDSGWDRERMRECWSFLDATSRSFAAVIKELKGELSRVICIFYLVLRGLDTVEDDMTLKPDVKIPLLLDFHKKLSEPGWNFTGSGPNEKDRQLLVEFDKVIAEYQMLNEGCRFVIADICARMGAGMASYIELGDSPNGLTMEGWRDYDLYCHFVAGLVGEGLSGLFVQTKIEKPLIGLQLSLSNHMGLFLQKTNIIRDYAEDCREGRSFWPKECWGSGGVFARQTEVQRGVVETYPGSNSYKFTDTVEGRKAREVLSTMLLDAVSHVTSSLEYLILLRDQSVFNFCATPQVMAIATLEVLVDNANVYKKNVKIRKSLAVRLILRSTNPRDVAGIFLDVGRSIHKKLRADDPNYIRCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8L5</accession>
    <name>A8Q8L5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729748.1">
        <property type="nucleotide sequence ID" value="XM_001729696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8L5"/>
    <dbReference type="STRING" id="425265.A8Q8L5"/>
    <dbReference type="GeneID" id="5854054"/>
    <dbReference type="KEGG" id="mgl:MGL_3292"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3292"/>
    <dbReference type="InParanoid" id="A8Q8L5"/>
    <dbReference type="OMA" id="YEVVYGH"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="105"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="330" mass="37348" checksum="C0A4EB68F275880C" modified="2008-01-15" version="1">MRSTRDMLKLDSCIRTLRTSAIIRQASPSSKPPPMAYNIFDREAKRLQRSRAALRRPVNTSGSAYEDMSRRGEMSRLTDYVRDIGAMNLAERLLDIQRPFPTVVELGAGPGLLRRHIDAAGVGIQKLVMCDMSEELLFRDRHLDKDYPFEIDRRIVDEEMLPFEENSLDCIVASGSLHWTNDLPGALIQIQRALKPDGVFLGYLLGGDSLFELRTSLMLAEQERQGGLSIHVSPMTDSRDISSLLTRAQFTLQTVDMDELTVHYPSMFELVQDLRDMGENNAVINRRTYMHRDTFLAAAATYQALHGTQEGHIPATFAQIFMVRVPMKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8W8</accession>
    <name>A8Q8W8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle SRP19 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729320.1">
        <property type="nucleotide sequence ID" value="XM_001729268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8W8"/>
    <dbReference type="STRING" id="425265.A8Q8W8"/>
    <dbReference type="GeneID" id="5853627"/>
    <dbReference type="KEGG" id="mgl:MGL_3355"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3355"/>
    <dbReference type="InParanoid" id="A8Q8W8"/>
    <dbReference type="OrthoDB" id="2527451at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22091" checksum="679AE8A065F241F6" modified="2008-01-15" version="1">MANYEFDDDTEFDLPESPAPINATNGIPPDQMKMMQSMMQQMNGLQSVSSTSSTPTESHVALDGQEDGPHKNWTCVYPIYLDAKRRYRHGCRRVPYEKALLFPNSQLIANAARKLQLEYMHEPYRKHPQDWENPGRVKVHLFDDHGAPIRPEFPTNDDEDGNDAASSSSQPPVNRQFPALGRRQRKRVVRIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9G7</accession>
    <name>A8Q9G7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729443.1">
        <property type="nucleotide sequence ID" value="XM_001729391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9G7"/>
    <dbReference type="GeneID" id="5853750"/>
    <dbReference type="KEGG" id="mgl:MGL_3478"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3478"/>
    <dbReference type="InParanoid" id="A8Q9G7"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053242">
        <property type="entry name" value="PAM2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651:SF1">
        <property type="entry name" value="SMALL MUTS RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="4">
        <location>
            <begin position="566"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="69079" checksum="57529AB1A0548C83" modified="2008-01-15" version="1">MTTGEHVHVRAYLHALFGRHCDKATYQEAENALLAQLEESRDADDEACTALHDILRVQVDRVLHQRMSDSELDAAALALMLRHRDDTLAQSTPVSQVLSCSTPSSPCSSSLYTPASTAATSTATAATPQIHAHVPEFRPRGALPVAYAVPSSSAATAHPVVTTTDAVVAPELHDDDDDEFSPFARSGNGDATSNMMMYGPSAADIYAGVAAADAGLHPLDSPPDISTLSLQVEASAPMLTPLEVFCSVFLAHNQGLFINEADPAVRLEQTSRLIQHALECSHYDVSAALQVVKEAHEAGRDLMAMEPPTSSGIDDTTTRVCRFFLAGECRRSDCRFSHDLNKALCRFWLRGQCLNDPCYFLHDYDALSMLAQSLVIAPTPPAPFQDLEQEQEGAWIERPKLDASQTPWAVAAKHAPTKSTTSAISTAVAPTFSSTKQARAATAPRPVQSHRIPLRPPSLLPTLSTGSALAIDTGKIRAAQPKNQDAWKTTLAVLHARHERLRERLQVGAGGDAGGWGASAQASQERGARGLRGRWIGSALGLCLGVAKPQVAGSSLSMDERTEAVLDLHGLHVSEALDTCEQFLLALESEGFRGLAYVCVGAGKHSVRSRGKLAGSIRDFLIEWEYPYADYDGILACDPCTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9H3</accession>
    <name>A8Q9H3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729446.1">
        <property type="nucleotide sequence ID" value="XM_001729394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9H3"/>
    <dbReference type="STRING" id="425265.A8Q9H3"/>
    <dbReference type="GeneID" id="5853753"/>
    <dbReference type="KEGG" id="mgl:MGL_3481"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3481"/>
    <dbReference type="InParanoid" id="A8Q9H3"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="1">
        <location>
            <begin position="37"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="202" mass="23182" checksum="421BC14D5B2A6308" modified="2008-01-15" version="1">MALRTTLAQLQAQPQGTPSALMRGLTRWKQSVRARAADISTRPGEAPMADVARKTFRHWRNEETGHWQPPKYSQRRQAQLVRAAYKMGTEDSVVSSPKFARYAQRMESMPTHEVLVGWPTVTWPTLSAEEDANEARRIARTYEAHGPYAGRSAARMFKGKKGERESYQRRQRVQEIMRTMDDTIAEWRKADARAKEKPLSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9K4</accession>
    <name>A8Q9K4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729462.1">
        <property type="nucleotide sequence ID" value="XM_001729410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9K4"/>
    <dbReference type="FunCoup" id="A8Q9K4">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9K4"/>
    <dbReference type="GeneID" id="5853769"/>
    <dbReference type="KEGG" id="mgl:MGL_3497"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3497"/>
    <dbReference type="InParanoid" id="A8Q9K4"/>
    <dbReference type="OMA" id="FWYTVSS"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="41"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="440" mass="47646" checksum="60C677444D94B129" modified="2008-01-15" version="1">MLSATRKALGISNSSHRSTRSDATVLSDAQSRASSVPLLIALCVLWYSSSALTSNTSKDLLSRRKVAATPDIRLPPLFPYPVTLTLVQFVFVNVLCYLGTRRNLLGDWVLARRLVHISLPQLRDIVQISVFNVLGHALGSLAVSRVEVSLVHTIKALSPLFTVLSYALFFGVPYSSRTYLSLVPLIFGVVLVCTSLSKSKRDDIVGFVAALGSTLIVVAQNIYSKKLLKPATSAATNAHEKLDKVNILFYSSVCSVVLMLPMCLFYDAKPMLAPTSPNVSIHTLYLLTVNGIVHFAQNMLAFQVLAHVSPVTYSVANLFKRVFVILVAIAWFGQDVTVTQWIGILLTFVGLYMYNNAKNESPSRTDSNMRADAASESLPMHATKSAIAMADAKPSWPPLAVQALNPNSASDQVPLPPRSPGESAPHSHVVLFPPQAAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9Q8</accession>
    <name>A8Q9Q8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3538</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729503.1">
        <property type="nucleotide sequence ID" value="XM_001729451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9Q8"/>
    <dbReference type="FunCoup" id="A8Q9Q8">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9Q8"/>
    <dbReference type="GeneID" id="5853810"/>
    <dbReference type="KEGG" id="mgl:MGL_3538"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3538"/>
    <dbReference type="InParanoid" id="A8Q9Q8"/>
    <dbReference type="OMA" id="VTNRNAI"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="475" mass="51917" checksum="9083BB3F1D414A82" modified="2008-01-15" version="1">MSSVQIPNDFNSVLYKPLSEADPEVQEIINNETYRQFTGLELIASENLTSLATMEANGSILTNKYSEGLPGSRYYGGNEYIDQLEALTQKRALAAFDLDPNVWGVNVQPYSGSTANFAAFTALIQPQDRVMGLGLPDGGHLTHGYYTAKKKITASSIYFQSFPYQVKRDDGYIDYERLRVNANLFKPRLIVCGGSAYPRDWEYNTIAEIAKEQGAYLLCDMAHISGLVAGKEQNNPFEYCDVVTTTTHKTLRGPRAGLIFFRKDREPDLEARVNAAVFPACQGGPHNNTIAGIAVALKQAADPAFKQYAKQVRANAQAIAKKLVSYGYRLQTEGTDNHLVLWDLRPIGLTGSKIEKLCDLVHITLNKNAVAGDTSAVVPGGVRIGTNALTSRSMTEKDMDQIGEFLHRAVEIAQVLQKEAGSKLLKDFIAKATTGEGEGRKMILQLADDVKAFATSFPLPGVPDTSVIKKPAGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA28</accession>
    <name>A8QA28_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729122.1">
        <property type="nucleotide sequence ID" value="XM_001729070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA28"/>
    <dbReference type="STRING" id="425265.A8QA28"/>
    <dbReference type="GeneID" id="5853428"/>
    <dbReference type="KEGG" id="mgl:MGL_3589"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3589"/>
    <dbReference type="InParanoid" id="A8QA28"/>
    <dbReference type="OMA" id="EVWCEND"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="66"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="290"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="564" mass="62474" checksum="44729DDDB896C344" modified="2008-01-15" version="1">MTERSNTRNQGFLPQKYNSGSSAGIPKQAGSSQETLVCPALHLYPLNDTFVPKQINLAPASSNNRIKIGRYSNNKTVPSPVNGYFDSKVLSRAHAEVWCENDKVFIKDIKSSNGTFINGTRLSPESQESEPFELHSEDVVDFGIDILTDDNKDILHRRVACRVFLVISPDDALKLRNDFSSLYRGGVHGGTLGNAGLCPGAEGGFRRGKPNINLDQVLGRIQIELHKSNMVGSELRTLSTAIEQIHNTLGGGVVPVQDAPHQELVPPKTNGLRESSVPTTEKESMDANTLANLESQLANAQTLLANHMEKIKELEATLAGYEHVKDEVSALKAEIAQTKLELINTHSLQGVARSPDRLLNSVREVSDGFNDAASTSSTDTVVPVSTGDNSDAERAAEVTEESAPMFSQRFLSGSENFASSSLLPDVLARIERLEKTFLEQGQQQQQQKQMQRKNDTFVLTNSDESFLQDWQQCFERKWEQQRNEWDKTHQKINDSIAFLNSQQAYQTKKVSPSSEPINPEIVLQEKKISKHAPDSLFQDFKLVLVIVSSLLVSSLITLYLSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA32</accession>
    <name>A8QA32_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729125.1">
        <property type="nucleotide sequence ID" value="XM_001729073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA32"/>
    <dbReference type="FunCoup" id="A8QA32">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA32"/>
    <dbReference type="GeneID" id="5853431"/>
    <dbReference type="KEGG" id="mgl:MGL_3592"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3592"/>
    <dbReference type="InParanoid" id="A8QA32"/>
    <dbReference type="OMA" id="REECIVE"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="31"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="176" mass="20714" checksum="44944099D18280B9" modified="2008-01-15" version="1">MTLSVDEYSKLSPDAQREYDNEERQRERSEQEGLPYRWNQMLDHVEVSIPLPPDVRARQIQVVFKPAWISVKMREECIVEGALFKPIQPDGCTWTIDDAKVLSVHLEKLNQNEWWPHVVTHHPKIDTTKIVPEESKLSDLDGETRAMVEKMMVCTKYYVRTTNTNQIENRQKVQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA33</accession>
    <name>A8QA33_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729126.1">
        <property type="nucleotide sequence ID" value="XM_001729074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA33"/>
    <dbReference type="STRING" id="425265.A8QA33"/>
    <dbReference type="GeneID" id="5853432"/>
    <dbReference type="KEGG" id="mgl:MGL_3593"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3593"/>
    <dbReference type="InParanoid" id="A8QA33"/>
    <dbReference type="OMA" id="STHQWEN"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="277"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="492" mass="55221" checksum="280A56B12C1F6E82" modified="2008-01-15" version="1">MARVVHLSSFQMVTFSSEVAEGKLLSKFHTPTKRKEPEESDDTHKKIKCSPIEIDSSNLPVPLLPSAQEPSYLCQWRAPQTRKHKTWDGDAILVVHENNKTCSLRSIHDGSMLITNASLRKRTVNEGDEFYVGGKEVLIERSMSGLIGDQGQNFGAQTHATSVPRHGPSMFSLPPRQKPIPASQFYSTPKSAITSTSSTLSAYRYSRSEPQSKFDSSSPDAVVMKRPNDKHYELFGKGCPIVDVVLDPELAPNLRPHQIEGVKFMYEAVTGISSLENGHASPGQGVILADEMGLGKTLQTIALISILIHQNCYFSPLRTGTVDKVLIVCPLTLVVNWKREFRKWLGRNSIGVLAVEGDGRIEVEQFVNSRQYQVLILGYERLRSSVQRLSRAIPAIGLVICDEGHRLKSRDTKTTRCFDILQTRRRILLTGTPIQNDLREFYTMVDFVYPGLFDQYSVFKRVFEDPIMRSRAQHCSSQALELGKKRNKAVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA99</accession>
    <name>A8QA99_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Aminomethyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_3658</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="4 12"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729191.1">
        <property type="nucleotide sequence ID" value="XM_001729139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA99"/>
    <dbReference type="FunCoup" id="A8QA99">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA99"/>
    <dbReference type="GeneID" id="5853497"/>
    <dbReference type="KEGG" id="mgl:MGL_3658"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3658"/>
    <dbReference type="InParanoid" id="A8QA99"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="14">
        <location>
            <begin position="287"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP41977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="373" mass="40302" checksum="7DFE6F77102B77CA" modified="2008-01-15" version="1">MVPFGGYSMPLTYEGVGQVASHKHVREHAGLFDVGHMVQHMFEGPTALAFLQHITPASLSNTALESFSSTLSVLLSKEGGILDDLIITKHSDTSFYVVTNAGRRTEDLAWIEEQLREWNDAHKSEGETTHRVMEGQGLVALQGPSSAAVLAKLVPSDFDLATLTFGRSAMIALSMKGDGSGNERVLCHVSRGGYTGEDGFEISIPAEATETVTQAILDNPEVQLAGLAARDSLRLEAGMCLYGHDLDESVSPVEGALAWTVGKDRRVTGDFLGAERVLRELKEGPPRRRVGLLVSPGSPAREGTKVFTPDGKTHIGRITSGIPSPTLGQNIAMALVQNGHHKKDTPLLVEVRNKMREATVTRLPFVPNKFYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAB2</accession>
    <name>A8QAB2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3671</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729204.1">
        <property type="nucleotide sequence ID" value="XM_001729152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAB2"/>
    <dbReference type="SMR" id="A8QAB2"/>
    <dbReference type="FunCoup" id="A8QAB2">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAB2"/>
    <dbReference type="GeneID" id="5853510"/>
    <dbReference type="KEGG" id="mgl:MGL_3671"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3671"/>
    <dbReference type="InParanoid" id="A8QAB2"/>
    <dbReference type="OMA" id="PLGFGCY"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="159"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="391"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="474" mass="52421" checksum="00C0BFA7B2F6DA09" modified="2008-01-15" version="1">MATQRLGHMLRVALPVRHGLSLYTRNRIAVSYVPLTQAARLAGVVAAPRAFSLWSSATEGNEAARKAVFERASEVAQKVEEVPSNFHERAHEVGLSVHDRLAQAEETVHSALTHEGESISHAAQLATTDMQELGLGGWSPSGLLQHLLDGVQYYTNLPWWATIIVVTCGIRLAIAPLLVYVQANSIRLSNIQPQMQAMIKDLEYAKSTGNQQEMQNAAINVRKLLSDNNCSPFKSLLLPAVQMPIFLSFYFALTGLAKAPLPALTTGGIAWFPDLTLADPYYALPIISSAMTLLVLETGAETGTTAMNQSSQARFMKNVLRGVTVLAAWLISSFPSAVLLYWSTTNTFSLFQLLALRTRFLKRLWRLPEKVEHPVKPHIKEKTFMENIRSSMNSGNARPSAATPVRRPSSAFYRKPQDTPEIMSQSRTRALDSLMSDDKSVKTSRASSAANELNQAEKQSRLAAARERRLRQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAP8</accession>
    <name>A8QAP8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729018.1">
        <property type="nucleotide sequence ID" value="XM_001728966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAP8"/>
    <dbReference type="STRING" id="425265.A8QAP8"/>
    <dbReference type="GeneID" id="5853325"/>
    <dbReference type="KEGG" id="mgl:MGL_3806"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3806"/>
    <dbReference type="InParanoid" id="A8QAP8"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF35">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="226"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="391" mass="44348" checksum="D813513C832CEE7C" modified="2008-01-15" version="1">MDVTGVLQRLIVRPSRTIGWLVGVWAGAWCTYYALQEIKRGLVLSSRRKKYPLKQRKGERLVSDKDWYGEADEAERQNIVARFGVMRFAGRYLNVTAEWREQGAWEWIWWKVVHSMIWNRGFGFDGGFTHDLKSPGGLARIESILPVEPLDIGRLWGQDTNEPAAPRTGVSYTWLGTKHMPYPVTRSHNLDRSCLWRSACGQCVESMAYAAYAMQAARLENGVSCERVHELSWWDEWRQPCHVRVRGEAGATSEASTVEKRELEVAAVPASHWSARTLLDTNRSLWNSYAVRCAAQDKQAATLFFCGDSGYSPLLFSSIGRMYGPFDVASIPIGSYEPRWHLSLQHMDPHGAVCVARDVGARQSFGMHWGTWCMSDERWDAPPRDLPASAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAZ0</accession>
    <name>A8QAZ0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729068.1">
        <property type="nucleotide sequence ID" value="XM_001729016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAZ0"/>
    <dbReference type="FunCoup" id="A8QAZ0">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAZ0"/>
    <dbReference type="GeneID" id="5853375"/>
    <dbReference type="KEGG" id="mgl:MGL_3856"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3856"/>
    <dbReference type="InParanoid" id="A8QAZ0"/>
    <dbReference type="OMA" id="KWIHLFH"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="7">
        <location>
            <begin position="35"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="279" mass="30983" checksum="2E90C3AB997DFFE3" modified="2008-01-15" version="1">MNVPVHGNFRRYYGMRRARVAGTTDPAPGRADDVDERIIALVEWCGTHASLLRPVERVLDVGCNAAKPLLELCQLMKPPPSYAEGVDIDSQLVRQARSALRRAWSQREPASTAASVEAMHYFPRCFGSLMGQLPLPPSASLEPGPAFPTNISFIEADWVRTHSANADSANVTENSMYDLILCFSLNKWVHLNQGDEGLVRLLARLASNLRTRGIVALEVQPWRSYSQARTLSRDLRRNHARLRLRPDDIGWIFSLFGLECLGPIAQGTGYGTSDETEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB23</accession>
    <name>A8QB23_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3873</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729085.1">
        <property type="nucleotide sequence ID" value="XM_001729033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB23"/>
    <dbReference type="FunCoup" id="A8QB23">
        <property type="interactions" value="666"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QB23"/>
    <dbReference type="GeneID" id="5853392"/>
    <dbReference type="KEGG" id="mgl:MGL_3873"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3873"/>
    <dbReference type="InParanoid" id="A8QB23"/>
    <dbReference type="OMA" id="YVEASFW"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="272"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP41871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="539" mass="60430" checksum="D91D423EEF69559C" modified="2008-01-15" version="1">MTTPAHPSAEQVLASIEQAGGEIQDSRTLSPVQMLPLNEQASRILQSSSDAQDKDDLQAEEAAHKAAAAWQIGLQGILLSLQSKEMINFRSIDAQPLFLTLDGRQTIRLGSPEYRLWSALPETGEGRSQPDLESMLGKDTFKLAQSRAFRNKIVRRLPDGTFARAESTLDQQLGDETRSELVELAKTGKLQGEGADKKIAELKKRKMVGQRKLLYFSMAKGPQFALTVQKLETDLTSDMLASGAWKKAAFKKYNFDAEGVLPPSGALHPLLKVREEFRHIFFDMGFTEMPTNRFVDSSFWCFDSIFVPQQHPARDVQDTFFVADPPSATEVPEDYLKRVIQVHENGAYGSIGYRYPFDVKVTEKLVLRTHTTAVSSAMLYSIAHQPGGFKPAKLFSIDRVFRNEAVDATHLAEFHQVEGVVADYGITLGDLIGFMQVFFSKMGVKNLRFKPAYNPYTEPSLEIFSFHEGLKKWVEIGNSGMFRPEMLRPMGLPEDVNVLGWGLSLERPTMIRYGIKDIRHLVGHKVPLESVERAPAVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB42</accession>
    <name>A8QB42_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729094.1">
        <property type="nucleotide sequence ID" value="XM_001729042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB42"/>
    <dbReference type="GeneID" id="5853401"/>
    <dbReference type="KEGG" id="mgl:MGL_3882"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3882"/>
    <dbReference type="InParanoid" id="A8QB42"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="124" mass="13910" checksum="1FD72AA628F692E5" modified="2008-01-15" version="1">MQINGIESRGIIDSGTRFILGKNEDVKNVLDAIDGLEIKKSGSGDWQGWYNCDDPPEVNIKVAGKEVKMRHDAMFGGRNNGKCLLTISSFQGAPEWIFGEPFFQMFSVIFDFDNERLGLGKLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBB0</accession>
    <name>A8QBB0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728902.1">
        <property type="nucleotide sequence ID" value="XM_001728850.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBB0"/>
    <dbReference type="GeneID" id="5853207"/>
    <dbReference type="KEGG" id="mgl:MGL_3896"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3896"/>
    <dbReference type="InParanoid" id="A8QBB0"/>
    <dbReference type="OMA" id="WLTITHD"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF54">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="495"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1650"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="944"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1650"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1677"/>
            <end position="1705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1855" mass="201629" checksum="F6B433E2D42D36A1" modified="2008-01-15" version="1">MDGATLTQYVFDATDTLISRLNKTWKSTLDSALALLKELHVHESSSKQWRQVSPGRDGTAPEDVPESVQLAVARRRIRSVDVFRATWAGPNGIDSDVDPDIQSGANGAGADAHAGADIGSLLALLSSQELLAEWFPQIESSEVLETLGLNTCLCKTRFKLGWPASPRDAVLLTHTVHDHVRVLHVATSVPRASDAPSYLRPSPPYVRAHVHILALFAQKVSLGRIAVTAYWAVDARGSVLGVRPNAMTSSFPRLLPAYVRTAKRIGTQIPYVAGYGRGIEITSLRATPALRLEYSVMDDDELPPHSEFFSDAHRETTPRSIRICLSTQHSWDVNIQAESTGNVHAKFTYTLERVDDKWNELCIRHAELEDPNAVVRTLLESKKSDDTLRRSVGSEADSETSETTNISVKDGAASTTVIVNGSAVRAISSEAGSSHTVIMPNKFLEQLAQADLKSPSLSTASELGHRSSVLSLNTSLHGASLPPLAATVRRNYVYFTSLLQEPEAKWKRVCDTRGVTVTQLDSIDPTLVVYRAEATFVGLSVWDLFSTLSSPSLAKLWCPSMQGADLLQDLGGQSSVWHTRYAPSWPVMARDATLVQTSYKSPSSIHVFSFSADEHLVEPLALPAPTSSTIRMHVDLYGWSIEALSPTTVHVTLIEQSDPRGWLSKTRVPSQMITAMAGAGDYALRQGPPPCTTRLLNARAQKLEYDADTSTYHLEYGVARDGSAEPVTHTECVLWCNMEVWSPNIDVRVTPAPASVSCLRRHRLAGGGGLWLTIEHLADDAQREAVSIVVRKGPSQSTERGVVLLNGMRVRVDTEGLNPAQLHALAHKKRSKPRRVPLDWMYQGLSPKSKSAAATLSNDTATAAHADAMSDADTSADADSVLASRRARAGHMPSDIPERVPIDTDGVETPDTEFKPEASEHGIALDPKAGEGSARNSDIKSKTTRSASSSASQSRSRSQPQSKLLSESPSQSQSQAPTDSIAETKEGPELTVPAMHAALQALTLLRHIHSERHPNPAGPQANWSFVSEKHGLYIHRRMIESVSAKVMVYRTDKIIQGVAADELLPLVTYPSVRCAWDENWASSRLLESFGSGASTSLWTSKGSFPFSPRMFIVSSMSAHSSGSGGRSDDATSIDTSSTVTHQPVYFHASASSDASRWDLKALLPASLPTGTVLLDGWIFENVDPYSMEQYAIPSTRCIHVMAIDYGGVPSGINTLWNASLAQAVLQLERCIKSYGPFPSVRTPPRCLFVCGDGRQDDQDHVWVLRRSRRASTLIMSDFDRTSRTWQVLLYVRNTSSSIVAGTGDKNQLINTPALDNKCTDISTAAASVTTPSTVSSLPATATATSTPHRPVSPSTQRLSSRSSAFFPKRTSSKEPTPIADVQVELQHYPLGYAVQILWCETSDTCDLTTRPDKVPNESLPVEVQIFDVPPSALQAATHAPDERSHRHCVRVTLPSSAPEHVRMKSALVCLVISPLGSHGQDVSSTPALRTPAMTSSTAAAAAAPAPASSSTAVSPMTSPHVPVTVNGRVAEIIYGHEAARDALDVDEDQLEYIRRDESIVSRSGCIHDVGQSVFSVPVASITAQPPATKPVDAVPAPKVEADISLSYNELTEIPSPQSGANTSSLFGIFRPQYRNRIYDGFVSLFTGQQKNQTTTSNASSTSAKSSDQTSKMHSQQRKQQQQQQEQQQHQHQQQQLGSSSLSGLQASERTVRQQARRFRLSTLILFVIISFLLGSLTRAFVQPADYVLVPYTSDRQVPAAPHRPVTDASKEGSSSESVRVIDLAAREIDNFVRAARQLHTFARFGSTETVPSESATQSDSMPDYTGLVQWREMHKFLDIYLPGLPWRLVVGLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBM1</accession>
    <name>A8QBM1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728929.1">
        <property type="nucleotide sequence ID" value="XM_001728877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBM1"/>
    <dbReference type="STRING" id="425265.A8QBM1"/>
    <dbReference type="GeneID" id="5853235"/>
    <dbReference type="KEGG" id="mgl:MGL_3923"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3923"/>
    <dbReference type="InParanoid" id="A8QBM1"/>
    <dbReference type="OMA" id="YLACAVP"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="624" mass="70696" checksum="B4337DED5083E5BF" modified="2008-01-15" version="1">MWQGTDTHALSALSIAFVVTVCISYTARVLASRRIALDELDSRSSSSFPILTQSSPLRSRSNRPHPFCASKASYESVQIVRVYWPITQTENIGSIYGWSWQSHKNEFVVVVACVHSHTAPRPWSCIPSARRLGECIPKHNSPSSTSHTQRQPVLASLHELGPHVILCDAELAVRPHQLSFFLYAPPKLLYGQSLTLGIQHVSDPQASFTRLERLVAMDPMRFEELRSPKRTGSLRMAIQYMNMAHYACIHTPIPPRRACVHGFLNYMPHLRLPILPHCCAKYSLLWCVVQKRVAVATAWSRYIMHWNTLRSHLETDGSVGNNLHAMQHAQQTSWNALLSLALDLGLGWLLAHILRRWQTVLVDTFRALLAYVDQAAFDALFNWLVHWPLGIKLNHELALFLADTLGSITLWYSMLQRLFDTHVPWFVHICIVACRIAGITAAIAMVADCLTVATLHLHVLYSILVHVYAFFLHAASELFDVFRGKKRNALHGGRLDNAEHEVDQLFVGTILFTLLVFLFPTVLLYYLACAVPFFFVHCTKTIIKKLVDIFYDLPLYTECMRHFDASYAPGGILIDIRPRKHHLRQIRASAITVREAWAPVVNHIQSLVHLLPDAYALLIGARIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC18</accession>
    <name>A8QC18_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728970.1">
        <property type="nucleotide sequence ID" value="XM_001728918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC18"/>
    <dbReference type="FunCoup" id="A8QC18">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QC18"/>
    <dbReference type="GeneID" id="5853276"/>
    <dbReference type="KEGG" id="mgl:MGL_3964"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3964"/>
    <dbReference type="InParanoid" id="A8QC18"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="8">
        <location>
            <begin position="166"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="640"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="668" mass="73960" checksum="EBD323AEABE09DBF" modified="2008-01-15" version="1">MPKTVDLRTQLAQRVACALRLRDVLGRNGYLAQLSISTRIHLRADAELLAGASDLWRLFDAGEHAAVLVTAIESVLGPGYERVFFEQALPRMVEILAALHAQLTPSNAVVCTRLVLALFLGATRFRLEHGAAYQQTSLPSSSTFEPWYASPVCIRLLESLFDAAINRLEHTQEAAADAELRTQLCALAEQALNAYEAREAFLSNDADGLAAAQAAFSRARPALLRPLLGIGRADKAFALAEHHRDFHTLVVLCFADPANNDDSKRIKLMNPASSDSSDVRVELYLDAYGMDFANELYQYYIKHGAVRRLLEPRAEHAHLVSRFLDEHPQYSRLAWVHDSALDQYERASSTLRACAQQERLDVQAKQRMLSIGKLLHLASLPSMEGVSAPAQQATLESWDDALDLVHIQTRLHARWVEATLVDESAPAEAQAEHIASSIAPLLDNRPTLRTLFVSFASEVIAGHVVTGEDIIDLLTLADRSFAAPQDSALTDFAIAVQVLVRLDLSSARRDAALVSLWRRLYLMDDWEALSDTASLTDEQVLQNVQNTTAFHTLQSVLADDSTAETVISPESICTMAPPDLSLLKERLQGLPDTQIQAIHDAFQEEHDALAHTVECTRLSAYFSHILSVRLINKEDWDMDDEDAPERKLEDTTTPLYETSMPGASTMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC93</accession>
    <name>A8QC93_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728816.1">
        <property type="nucleotide sequence ID" value="XM_001728764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC93"/>
    <dbReference type="GeneID" id="5853122"/>
    <dbReference type="KEGG" id="mgl:MGL_3983"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3983"/>
    <dbReference type="InParanoid" id="A8QC93"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="420" mass="45879" checksum="5BD9CC97E03D8C62" modified="2008-01-15" version="1">MSRVMCLALALASLTVPRGLRRLKHHMADLRHWLPKKKEIQPSSASCLDHLHRWRVLAYERKSFHVNVRKSAYSMPGVRHDPADSLLWSMSELSLTRRAQGEKPSRSPSLPVQMESNRDPSLYSTASVSRASEPTQFSDIMLLPSRSSRSASIQSNQLLPPPSSSRTQGGSSMPDIWKPPPQSTPLRLTSHSSDLPMSSVPLHAPRHSAPHVLPERVLGSPRPSPQYSLDRPFSLLQHNTLEQRRGSDTLSVPGSMLWTPIESVESQSVRRRRSVHVAAAAAAAAAAAAAAAAIPEVPRYEYADVPMSIPPSREITSAPATLSQSDSASSQMNKSRLSLSQAEMPPEFMSPSSHKSTPVAWKNTLTSRPPPATCAFSHDTMPPDTIPPETLPPDVAPPDILSPTCMPPGYNGARRYTLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD01</accession>
    <name>A8QD01_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_4069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728734.1">
        <property type="nucleotide sequence ID" value="XM_001728682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD01"/>
    <dbReference type="STRING" id="425265.A8QD01"/>
    <dbReference type="GeneID" id="5853060"/>
    <dbReference type="KEGG" id="mgl:MGL_4069"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4069"/>
    <dbReference type="InParanoid" id="A8QD01"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="211" mass="22154" checksum="10F7B1EEF82FE9DC" modified="2008-01-15" version="1">MAEGLARAGASGLGDNVIAQLEDKIEDLEEQLAAKRASLPTPVTQEHDHVEALCLYALVLVGALLPDGEALAHSMSLPLDALHALFAPPRFDEEGRADLAALPVAAASAALRTTLECLRAAGPAQKRTSSLAFVSRVQQTLDSLSSSATSAAGPHGIASLVSDVFARLLGTLDTSEMITERAKVLEDSVHGYNDTDTDASRSLTHYVDGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD07</accession>
    <name>A8QD07_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NAT10</name>
        <name evidence="14" type="ORF">MGL_4075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728740.1">
        <property type="nucleotide sequence ID" value="XM_001728688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD07"/>
    <dbReference type="FunCoup" id="A8QD07">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD07"/>
    <dbReference type="GeneID" id="5853111"/>
    <dbReference type="KEGG" id="mgl:MGL_4075"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4075"/>
    <dbReference type="InParanoid" id="A8QD07"/>
    <dbReference type="OMA" id="HLHYIMS"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="555"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="995"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="995"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1023"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1044"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="624"/>
            <end position="626"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="631"/>
            <end position="637"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="717"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP41526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118040" checksum="95C9BC4833D20731" modified="2008-01-15" version="1">MRKQLDPRIPTLIRNNVSSGHRSFFVVVGDHGRDQVVNLHFLLSQSRVEARPNVLWCYKKDLGFTTHRKKREAKIKRDIRRGVRDQDSQDPFELFVGVTDIRYCYFKDTPKILGRTFGMLVLQDFEAITPNMLARTIETVEGGGIVVLLLQNMSNLRQLHSLSMDVHKRYRTASTDEEPVARFNERFLLSLSACADCLLLDDELNVLPVSNGRDIRPLPETQSSQSTGGVGAAVRRDAATREREENIAALRADVSETRVVGDVIRHAKTMDQATAVLTILDVLASSSLSTTVTLTAGRGRGKSAALGLCLAAAIAHGYSNIFVTSPSPENLKTLFEFVLKGLDTLGYDEVADWDLQRGTGEWKDTVVRVNVFRGHRQTIQYIQPQDHAVLSQAELLVIDEAAAIPLPLVRQLLGPYLVLMSSTINGYEGTGRSLSLKLFQQLRANSSSVGARTLKEVELREPIRYAPGDKVEAWLNELLCLDASLAKMPTHSRDGCPHPSTCDLYMVNRDTLFSYHPASELFLQRIMALYVAGHYKNSPNDLQLLSDAPAHALFVLLPPLSSGTLPEPLCVVQVALEGNISRQAILNSLARGTRDAGDLVPWLMTQQFQDADFASLSGARVVRIAVHPEYARMGYGARALEQLEMFYEGALLDPDAHAEKVARDASRPATTRTELGGREPKSLPPLLERLSERQPESLDWLGVSYGLTSELFKFWRRAGFTPLYIRQVPNELTGEYSAVQIKTLHGQQSWLSAFAGDFRKRFCNLLSFRFRELRTVTALGILEAASAAVAAVPAPEATAARTTESVPLSYPELRMLLTPFDMKRLESYGNNLLELQIVVDLLPTLAMLYFGRRLRSADDESDMERELSVSGLSAALLLAIGLQRRSLDDIASELQIAVHQAHTLLCKAVRHMVQSLRALEKRDAEAVVDAQAPRIEQQKLWAPVAENLEEELADAGRDAVEPDAGQRAFTQELLNDTEMSKYAIAQDDDNAWKEAEARVRKMQDDSTGRSYSSTFSIRAPEAAQRDSESGRQDDVSSSKKKRSAPSSNKAAASGKKRRASRAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD30</accession>
    <name>A8QD30_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_4098</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728763.1">
        <property type="nucleotide sequence ID" value="XM_001728711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD30"/>
    <dbReference type="STRING" id="425265.A8QD30"/>
    <dbReference type="GeneID" id="5853032"/>
    <dbReference type="KEGG" id="mgl:MGL_4098"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4098"/>
    <dbReference type="InParanoid" id="A8QD30"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="529" mass="58154" checksum="81D69D5528134D75" modified="2008-01-15" version="1">MASKVRPLLAALNQSGKYAYREPDMRVDHLVIGGGVVGLAIANALAHRWPDKSTYVVERHAVLGEETSSRNSEVIHAGLYYPHDSLKTRLCTRGRELLYERIARSGRIGAEQVGKLIVGSANDTAYLEGLYKHAQSIKQHAPRVRLLNGEEARELEPDLSPHITRALYSPSTGIISSHDYLSDLACELEELPTGEVPDANVVLGTSVVRMDPHTPNRAALSKAGDDGSQEGWVVQLRTHDASHNETDSLLARVVINASGLNAPRVLNSLWPQASPSQWVPMYFAKGSYASYRGPGVKHVQHLLYPTPEFSKQASQRAHAVQSLGTHLTLDLDHHVRFGPDLSWLSPPADVSDWHLDDELGFQHDFWEKCLAPDPSDAWFDSMYEAIQAYLPGVSREGLQVDYAGIRPKLCGPDAQRFQDFGVLWHASRHVERQHVWQSSAAEAGRAASGLLVSLVGIESPGLTASLALGEHIVKELEAHLWGRHNPRGRARKYVDDIGHDAPGRMGIEDVDAKKQAKQAGRQTGRPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD67</accession>
    <name>A8QD67_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_4135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728800.1">
        <property type="nucleotide sequence ID" value="XM_001728748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD67"/>
    <dbReference type="FunCoup" id="A8QD67">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD67"/>
    <dbReference type="GeneID" id="5853080"/>
    <dbReference type="KEGG" id="mgl:MGL_4135"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4135"/>
    <dbReference type="InParanoid" id="A8QD67"/>
    <dbReference type="OMA" id="FETWYAM"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="324" mass="34293" checksum="CBB7F7C1A68A2D69" modified="2008-01-15" version="1">MTSVMENSLPTPPAERTVSFVLRGIQDTAFEDRPVRPLHDGEVRVNVRQTGLCGSDCHYRSHGRIGEFVLTSPMVLGHESAGIVTEVGPGVKSHAVGDRVALEPGVPCLSCGLCLEGKYNQCRKLVFAATPPYDGTLATYYNIHASFAHNVPDTMSLEEASLMEPLSVAVHAVVTRAGVRALQNVLVLGAGPIGLLCGAVARAYGARRVVMSDLVDEKLVFAREFCATSTFKPNSPQVGESEGDLAARTACALKEELGDDVLRNDGFELVIDATGAQSCIMLGVWAAKPQGRVVAVGMGRPDVLVPLTRLCRAGGGAFGIVPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2023-06-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDY3</accession>
    <name>A8QDY3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000024">
        <property type="protein sequence ID" value="EDP41405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728619.1">
        <property type="nucleotide sequence ID" value="XM_001728567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDY3"/>
    <dbReference type="GeneID" id="5852927"/>
    <dbReference type="KEGG" id="mgl:MGL_4244"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4244"/>
    <dbReference type="InParanoid" id="A8QDY3"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728095" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="59" mass="5994" checksum="604B045AE0415A9D" modified="2008-01-15" version="1">MQFSLNIAAIALALATAAAAAPIDFAARPTFMPGPIVSDGSYTGYNPFKAVVSTSTSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8QES6</accession>
    <name>A8QES6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_4282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000047">
        <property type="protein sequence ID" value="EDP41365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728579.1">
        <property type="nucleotide sequence ID" value="XM_001728527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QES6"/>
    <dbReference type="GeneID" id="5852887"/>
    <dbReference type="KEGG" id="mgl:MGL_4282"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4282"/>
    <dbReference type="InParanoid" id="A8QES6"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="87"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="252" mass="28011" checksum="A2D7DEC043F07569" modified="2008-01-15" version="1">MEGGTFPKVGSLKLNLTGTLTYGQKDAKMGDGEKNRRTDVKPFDDTKLVPMEKIESKEPDMRVTLEVKMKEGRKHGKPMGLINGTTYVAPKTPTMLTMTAKNTTNPMDAGTYGHNVNAVTAPYNSMVELTILNLSDDVHPFHMHGTKSQVVHRAYGTDGKKPQVPKVEEQENPVRRDTVAVDGFGSVTIRFVASNPGAWFMHCHMDWHLSAGLAMEMVQAPEKAKEVLKVPSYVEEQCKVWKKQSDQKLRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQZ0</accession>
    <name>A8PQZ0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0546</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732771.1">
        <property type="nucleotide sequence ID" value="XM_001732719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQZ0"/>
    <dbReference type="FunCoup" id="A8PQZ0">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PQZ0"/>
    <dbReference type="GeneID" id="5857077"/>
    <dbReference type="KEGG" id="mgl:MGL_0546"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0546"/>
    <dbReference type="InParanoid" id="A8PQZ0"/>
    <dbReference type="OMA" id="LFMRNWN"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="13">
        <location>
            <begin position="194"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="12">
        <location>
            <begin position="268"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="346" mass="38278" checksum="542FFDF1C6A7BC1B" modified="2008-01-15" version="1">MRNWSTADEHGIMHGGSGGAMGCDWQREWHDVQAVCRHLGGMQVEMIDLSRDYWVHVFEPALGQWSDGTTPNPDVECNKFIKFGALMDRVVPKSLIPATWLATGHYARIAPRIEHTHIYPVVRRAADPTKDQSFFLSSVSSSRLDRSLFPLGDMHKSDVRSLARSLALPTCEKSESMGLCFVGERGSGAHAFARFLDQYVANEAGAFVTPEGQYLGMHRGLHTLTIGQRARISGKPQRYYVARKDPVTRQIIVVPSKSHPMLQCTSLQSTVFSWVTGVPVLDTQLLAQVRYRQNAVPCFVRAHGLDGVHVEFTTSVEAVSPGQTVVLYDGELCLGSGTIDHVQTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR22</accession>
    <name>A8PR22_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rnh202 triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732803.1">
        <property type="nucleotide sequence ID" value="XM_001732751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR22"/>
    <dbReference type="STRING" id="425265.A8PR22"/>
    <dbReference type="GeneID" id="5857109"/>
    <dbReference type="KEGG" id="mgl:MGL_0578"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0578"/>
    <dbReference type="InParanoid" id="A8PR22"/>
    <dbReference type="OMA" id="DRSWMIS"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="1">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="268" mass="29618" checksum="0CF6DA2C74612A4E" modified="2008-01-15" version="1">MSAASSQQRDRPPVALAFPSEVTNDDLTQLWVLPHPRSGAPAYYAISNDGHGTLFELIVTRPTAPASQSWFLREATSFEGQVVADGAMHILSRIDPAFVLLGILGLEHDGKRFWPLDDWAEAATDAHVTRRLALHTDPSSTSCSSQSPTALTNAWPDITAFVLHPMMHKHLLRICSTQPQTHTCDGLVYRLDWSRVIAILDEKVERLCVGAHDILTAQSARSTGCSDEAFDTPETDGIRRIAREWIGAYLAHHIRERWASGESTSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR43</accession>
    <name>A8PR43_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732824.1">
        <property type="nucleotide sequence ID" value="XM_001732772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR43"/>
    <dbReference type="MEROPS" id="A01.078"/>
    <dbReference type="GeneID" id="5857130"/>
    <dbReference type="KEGG" id="mgl:MGL_0599"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0599"/>
    <dbReference type="InParanoid" id="A8PR43"/>
    <dbReference type="OMA" id="VDNITPP"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727838" description="Peptidase A1 domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="107"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="544" mass="58426" checksum="07C19309996A91AF" modified="2008-01-15" version="1">MVIGFVALGCAVLASTVAVQASPTATRSGPTASATADAHGLQVPIYFNGKALHPRNRNMNEDQLSEWLMAEHNKLKVKYTHPKDRQPSNRSKRQQLGLGDFGLDSFYFAPIGVGSPELTLNVVLDTGSADFWVAGTSCSLMDQCQQGMIKFDPSKSSTFKDNGLPFSVQYGSGAVRGELASDKVSLAGYTISSLSFGLAKELARNTIGPPASGILGMAFNTLSTTGTMPFWQVLLERRKMQNYVFSFQLVNNLEKANSQDAKEVAPGGVFTLGVLDDQQYSGNITWSSLSKGYGPNGVGYWAIDIEKLNINGKELKLGELNIAAIDTGTTLIGGPENVMDAIHSRIRGAQKYARAPQYYVFPCRTQINLDFTFGGRTWKLTTKDLISHQLTSNMCLSSLFISPTQSPNMPSWIVGDTFLKTVFSVFDGAKARIGFASLHQGGAQTMSLTSATMDNSLANKGAKESTEAGPMSDESSAGMPHGGNTPGMARSNTDNAWKTASIFVPHDIKPIDPPKGSSHFVKPANIVTLLMVSVMTLTVSMVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR49</accession>
    <name>A8PR49_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 6">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 6">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 6"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732829.1">
        <property type="nucleotide sequence ID" value="XM_001732777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR49"/>
    <dbReference type="FunCoup" id="A8PR49">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR49"/>
    <dbReference type="GeneID" id="5857135"/>
    <dbReference type="KEGG" id="mgl:MGL_0604"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0604"/>
    <dbReference type="InParanoid" id="A8PR49"/>
    <dbReference type="OMA" id="GWKRDWH"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="53"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="504" mass="56493" checksum="6B9E50BAC99469BB" modified="2008-01-15" version="1">MLSRRRHQVRGTRNPVKQLGDHEAASTGAIEPNVPPELVSTKPLPLPADFEWVTIDMEDDAQLSEVYHLLTHHYVEDGEATMRFKYSPAFLRWVLHHPGYDKSWHVGVRVKSSQKLVAFIAGIPQELRIHDSVLQVTEINFLCVHKLLRSKRLAPVLIKEVTRRCHKSGIFQAIYTAGQVLPTPISCARYYHRTLHARKLVEVGFSSVPRGMSMAQHEARYKLPETTSLPGLRPMQTRDVPAVGRLLRRYMARFDMAPRFSDAEVRHLFAQAVPLDTRPVTWAYVVERHDGAITDFFSFYSLPSTLLGHEQYDTLEAAYLFYYATDAAFDDGAAQQSASTPTPPPAQQATDQTISPYEAARQRGQAAWQCSALSRLSPAEAADEADVRPWHTESHASRERLKARLCALMNDMLVLANKEGFDVVNCLTVLDNPLFTHELKFGPGDGFLRFYLFNWRIAPIAGGMGSRADEDALDPAAASSEENEHVPRPLPPSIYGSGNGIVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR68</accession>
    <name>A8PR68_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732842.1">
        <property type="nucleotide sequence ID" value="XM_001732790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR68"/>
    <dbReference type="STRING" id="425265.A8PR68"/>
    <dbReference type="GeneID" id="5857148"/>
    <dbReference type="KEGG" id="mgl:MGL_0617"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0617"/>
    <dbReference type="InParanoid" id="A8PR68"/>
    <dbReference type="OMA" id="WEMADIQ"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="491" mass="55727" checksum="DF606A0D506B305A" modified="2008-01-15" version="1">MNMSAIVDVHQPMGSMSLSPSHQEVVLGSNMGLFVLQLEHLYTPPRFFAHSTPWEMADIQWNPHMARSAWVASTSNQKLVIWNLDRPSGRFGCVQAVPTLPPSIRSKMQMDVARSCKTHSSPSSAGRGSFMYGSHKLPVDSASRILPHASDGRNQNGIPSSIEHLLNAHTRAITDINWSPFHPEVLASCSVDTWTWIWDLRMANSGSGRPAQGYSSWNASMTQVKWNRGIEHRIAASCDDKVLIWDDRFGALPLVTLETRQSKIYGLDWSLPGNERNNRLMTCSLDGTIKFWDLDSPSSRRVAAHYARIDQPESTIETLQPVWRARHLPFGHGAISVAQRGDTAATLWAYGSQEPVCRFEGHMDLVKEFVIRSRSGSNANLDDRTFQLVTGVRTKHSVFGLSVLMLCEHWGTSKVRRCITYSQSLQLLLIRLDRRRRRDRRHQQHSQELYQCRQQDPCRRLHAPRHRGHRLTGGQVRAVVDTQTWVRGRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR71</accession>
    <name>A8PR71_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732844.1">
        <property type="nucleotide sequence ID" value="XM_001732792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR71"/>
    <dbReference type="STRING" id="425265.A8PR71"/>
    <dbReference type="GeneID" id="5857150"/>
    <dbReference type="KEGG" id="mgl:MGL_0619"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0619"/>
    <dbReference type="InParanoid" id="A8PR71"/>
    <dbReference type="OMA" id="ESTHEMD"/>
    <dbReference type="OrthoDB" id="10255344at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="398"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="540"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="620" mass="71184" checksum="E2EDD0325ED9AACC" modified="2008-01-15" version="1">MSRYSHFGTTTRTPRTRRECASDELHTRVRLSMDVPADVREWAVHTLRALQSGIHARLIGKMFADDIPSPAPSDLDDTRDVFMHLGVLLTECNDLLDFERAESITKRGDELCSSARDENSAFNYALATQAVHSLQAELHALRGETDPDATFVDSHVPWQSSSDWRGLAQDTIQSMNERHASELAHIYEQHADELEALRNEHATDLEHVSAQHASDIRTMENGYIKTIEHAAQDRAGEAERHKLECLERETQYSAELKQRQQSWDEREASLTAKLEEMHRTWDKREAEHKTELEHVQHMWHERDVQRATDFEQIQRTWEVASETLGFALDSLQHAVASQGSQLAPLHGRIQSLNRLLDTFAQERDAANAEALAWSERHAEAQAHIAALQVEITSKNTDLVQQTSRLVETERKLKEVQNEIECSAHVQANIDELQERLSAADHDAWQLREQLRSLEPLRTERAQLSSEVHELQKLVSMYKDSVAHAQHEHEQTQQQLERTETQRFAIEQALREREMELRDLYEAKRIWTEQRRAFKARPSVSNEATQRVAELEIELSAKATEVEEADTRLLTVMKENKRLAAQLKSLKMDAKRALQDVTNATSKTYSPTKADARVARYRPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR87</accession>
    <name>A8PR87_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_0630</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732855.1">
        <property type="nucleotide sequence ID" value="XM_001732803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR87"/>
    <dbReference type="STRING" id="425265.A8PR87"/>
    <dbReference type="GeneID" id="5857161"/>
    <dbReference type="KEGG" id="mgl:MGL_0630"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0630"/>
    <dbReference type="InParanoid" id="A8PR87"/>
    <dbReference type="OMA" id="DIHEIMI"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="14">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="347"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="477"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP45641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="558" mass="61970" checksum="D9292F3DEAB0031A" modified="2008-01-15" version="1">MDVAREQEADREIWDEEDNTFDGWDDEGAVPTRALFPGDEDRTFSSADEALEHAKSQGCDLRALVKRLQLDSWQLIRLINYIRRPTTSPRPTPESIMSLTGHEAFLTDDGEMQPVPGYEQDGLLQLDLTEETERMDPNVELAMLRAAYDELRHQYAERLGITAATAQASARASVPVPAASPVDAHYFESYAGQDIHQTMIGDTVRTLSYAKFLLSPENAHLIQGKTIMDVGCGSGILSLFCARAGAKHVLAIDASDVADRASANVEENGFGHVVRVFKGKIEALDDDLRAWAGQVDLLVSEWMGYFLLYESMLPSVLYARDRYLRREGILAPSHCRMLLAAATDCSALCERTRFWRNVYGFRMPSMTRGLTSDAATEDVEKEAIVSDAATIYDLPLETLPAEQPEFAAPFSLTIQKSCTVHGFVSWFDTWFTPAPRVPTSELPPVTTAPVQERDVFGLDMQGSQVVPAVLTTSCPGETVSFTTSPFGKPTHWKQTIFLLKTPIEVDAGSCLQGEIHVYASKSNARELDVDIHYAVDEHKRPAGEKRVSTRMMQAYCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRZ8</accession>
    <name>A8PRZ8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732388.1">
        <property type="nucleotide sequence ID" value="XM_001732336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRZ8"/>
    <dbReference type="FunCoup" id="A8PRZ8">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRZ8"/>
    <dbReference type="GeneID" id="5856694"/>
    <dbReference type="KEGG" id="mgl:MGL_0163"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0163"/>
    <dbReference type="InParanoid" id="A8PRZ8"/>
    <dbReference type="OMA" id="WSMNAGA"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="311"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="789"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="834" mass="92713" checksum="88FF97470C2CFFA3" modified="2008-01-15" version="1">MSTGDPSREAIVHIDSNGDGQPESYALPPAIHLNPEGAIERQNLLPSTTNYGSAYTNELQTTSFSSPANYGSENGRGSPTYSIPPPVKYGPENEEVSRTNSFSQPANIGSKGVDETVRYSSPAFGHAELEDIKESENYSLPPHANHGFENGRGSDVLSLPPPAPFSDRSAQAGSMGYEGVSSQIPGRSSPQTPVSLRRPQSTAEQSTGSEPQANTVPYGWMSGIDEHNNDDDLHDPAKPMRGSFEPTRAVVNVGTLILLVLCLLMLFAGYPILHYYTEDKNDDDRLKSFKQIFDGENVYPSNAPFLRMNDSKLQNNFDPSKVMFIDPDTPKEAYTMKSTFTGMDGKEFKLVFSDEFNTDGRSFYPGEDPFWEAVDLHYWATNNYEWYDPAAIYTSNGSLRIRLEQHPEHNLNFRAGMLQSWNKFCFRNGILIGRIQLPGYPKVAGLWPAFWIMGNLGRAGYGATLQGTWPYSYDQCDVGTVMNQTLWNATYPDGFPEGTTDLGGATVFNQKHNTRALSFLPGQKLSRCTCPGEDHPGPFKDGQFTGRAAPEIDVFEAQVGYFDHTDIKGMTVSQSCQMAPYNWQYDITKYNESDAVHLFAKYSLLNSYNGEITQQSLSGVSPASQEAIQYSANTKDTENDTAFAEYALEYRGGPYGYVSWLSNGAKAWEIYKDALVADKKSQVGNRQFPREPMYVLLNLGISRNFGDFEWDDVIPGFPFEMAVDWVRIYQDPDDPESDIGCSPDDMPTAEYINRHMEAYTNPNLTVWGGSRDEGGYGAYWPKNRLYNDGNGCKTDRSKEPGDPNPSYRRRAPYVPSSSVIAGPGAQTTYPPKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS53</accession>
    <name>A8PS53_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732421.1">
        <property type="nucleotide sequence ID" value="XM_001732369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS53"/>
    <dbReference type="STRING" id="425265.A8PS53"/>
    <dbReference type="GeneID" id="5856727"/>
    <dbReference type="KEGG" id="mgl:MGL_0196"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0196"/>
    <dbReference type="InParanoid" id="A8PS53"/>
    <dbReference type="OMA" id="ETCELVY"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="220"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="312" mass="34836" checksum="D35FBE61C0C7E2F1" modified="2008-01-15" version="1">MNGRQPNERSSIYSRFEQVSTFEVPSKASPQTAQDGVVHVPFGIVHLFRMLDDPAKSDTDKSLCALAEGDEQDVGDDHLGTVLAMLNIPASVTVSNILEFFETALEAIEQVRVIEHEQHGYLMLLLKFRDALDAEQFFKMYNGLPFDGMQAEETCELVYVTGFTASGSTTPPVPYPMSSNLEPWPIIHASSNEPDASLRALRPYRSGSGLRENAFELPTCPVCLDRLDARLSGIITVMCQHTFHCTCLQRWSDSRCPVCRHSYVRHFRGTESASQRGDAFSTVFSNCSACGNQTNLWMWYVYMSSPPLSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS79</accession>
    <name>A8PS79_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0209</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732434.1">
        <property type="nucleotide sequence ID" value="XM_001732382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS79"/>
    <dbReference type="FunCoup" id="A8PS79">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PS79"/>
    <dbReference type="GeneID" id="5856740"/>
    <dbReference type="KEGG" id="mgl:MGL_0209"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0209"/>
    <dbReference type="InParanoid" id="A8PS79"/>
    <dbReference type="OMA" id="FCWLVIH"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="300" mass="33064" checksum="8509A6CD07F86921" modified="2008-01-15" version="1">MNSLYNLAGRQSAAIRADIDAYSRDPLAHASLRSQIMTSLSAFVKTIEDYEAIAKRELVISKREKALNRAANFHAEVRQFREELAHVQARPPTNASSALSFHAGANPNTTATRARVVDMQPSIGQGGVYSTELTQSSSTYAPYQPMGYSTPSTSTHHMSGIPTVSVTTGQPSYSTPAMPTPQQDPLAAYRIHSATYAPPDERTYSMRESHALREHSFIQNTESQLDAFITQGRSVLGNLTEQRGILKQTRKRLLDAANTVGLSRELIGVIDRMSTQDTILFFGGAVLTLTAFYFIYRWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSD7</accession>
    <name>A8PSD7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0239</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732464.1">
        <property type="nucleotide sequence ID" value="XM_001732412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSD7"/>
    <dbReference type="FunCoup" id="A8PSD7">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSD7"/>
    <dbReference type="GeneID" id="5856770"/>
    <dbReference type="KEGG" id="mgl:MGL_0239"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0239"/>
    <dbReference type="InParanoid" id="A8PSD7"/>
    <dbReference type="OMA" id="RTLDEGP"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000009">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="13">
        <location>
            <begin position="52"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="471" mass="50149" checksum="F958EB48E94F0F1D" modified="2008-01-15" version="1">MSHIETQVLPVAHTWHASKPTDFGLVFADATAASSQEPYESLAVSFTSDVTRSSLEKAASHLRSGQLVAFPTETVYGLGACALRTDAAERIYHAKNRPADNPLIVHVSDRRMLSKLLPSKYPYNAACEALMKAFWPGPLTLLFPVGLDDQGLPRIPSTVTCGQSTVGLRMPSHPIARALISLAGVPVAAPSANASGRPSPTTAGHVFTDLGPRHVLSYIVDGGECSIGLESTVVDATTTPGEVRVLRPGGISVEQIAQALEQAGLSSLSLRVYGRDLARSAQQEAAPTTPGMKYRHYSPEARVLLVRIDDGEHPTVHELLRDVAASRAQAEQEARIGLLCAHDSPLILSLPDSALTRWAADATHASSSSFTDKAESRLSPVVHVNGMKLCLYSLGRRDTPSAAAQRLFDGLRTLDACVPWCDGKPGACDAIITDVVDESGVGLAIMNRLRKAASATLFARADAVRPIHIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSM0</accession>
    <name>A8PSM0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732506.1">
        <property type="nucleotide sequence ID" value="XM_001732454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSM0"/>
    <dbReference type="FunCoup" id="A8PSM0">
        <property type="interactions" value="551"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSM0"/>
    <dbReference type="GeneID" id="5856812"/>
    <dbReference type="KEGG" id="mgl:MGL_0281"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0281"/>
    <dbReference type="InParanoid" id="A8PSM0"/>
    <dbReference type="OMA" id="KPRYKAP"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="233" mass="26788" checksum="BD78105EA08184C5" modified="2008-01-15" version="1">MKLNVANPATGAQKSFEFMDERPVRCFYDKRMSQDVEVDSLGDEWKGYVLRIGGGNDKQGFPMKQGVLLPSRVRLLLGKGDSCYRPRRTGQRRRKSVRGCIVGPDIQALHCIIVKQGEQDIPGLTDPESAVPKRLGPKRANHIRKFFNLTKEDDVRQYVIRREIQPKKEGAKPYTKAPRIQRLITPQRLQRKRDARRLKKEFIAKKHAQKAAYDALVAQRVAEKKQRLAHHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSN7</accession>
    <name>A8PSN7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732515.1">
        <property type="nucleotide sequence ID" value="XM_001732463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSN7"/>
    <dbReference type="FunCoup" id="A8PSN7">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSN7"/>
    <dbReference type="GeneID" id="5856821"/>
    <dbReference type="KEGG" id="mgl:MGL_0290"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0290"/>
    <dbReference type="InParanoid" id="A8PSN7"/>
    <dbReference type="OMA" id="LFWESHD"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="174" mass="19755" checksum="DD6F3B4663BB31EF" modified="2008-01-15" version="1">MSSATTEVATFANGCFWGTEHLYRKYFGGKGLLDAKVGYIGGNKPNPTYREVCTGKTGHAEAAQLSFDTSKVSYAELVEFFYRTHDPTQWEGQGPDIGPQYRSALFPHTAEQEATARRVTEQVQAKHFDPKGMRIVTTIERAPVSDFFEAEPYHQEYIINNPNGYHCPTHRLWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSS3</accession>
    <name>A8PSS3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732532.1">
        <property type="nucleotide sequence ID" value="XM_001732480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSS3"/>
    <dbReference type="FunCoup" id="A8PSS3">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSS3"/>
    <dbReference type="GeneID" id="5856838"/>
    <dbReference type="KEGG" id="mgl:MGL_0307"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0307"/>
    <dbReference type="InParanoid" id="A8PSS3"/>
    <dbReference type="OMA" id="WEDVWSV"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29872" checksum="A8D2FA332766BD82" modified="2008-01-15" version="1">MKQFDVRHVAMGALLLATKQVEVPVRLRELLLVFDFLYQRGLHYAKSSPGVRTKESHAGVHAVEANQEKKAAPIFKYQACDSHSTTMYDAKDAVMVAEMQILKRLGFHVQVELPYALMINYMQVMGILEVQLTSTRDPDTKLHAPQIAWNYLTDALQTPVYCLFPTHVIACASIYLMTLHPNTLHEPLPLPLQPRPWWEVLDCTRNELRTVAAYIFRLYDTSTGGTSRAGHGFAVRVREDEGGLVDIASRTGIRAWLEHTEKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTW7</accession>
    <name>A8PTW7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732715.1">
        <property type="nucleotide sequence ID" value="XM_001732663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTW7"/>
    <dbReference type="FunCoup" id="A8PTW7">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTW7"/>
    <dbReference type="GeneID" id="5857021"/>
    <dbReference type="KEGG" id="mgl:MGL_0490"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0490"/>
    <dbReference type="InParanoid" id="A8PTW7"/>
    <dbReference type="OMA" id="DRSNCKR"/>
    <dbReference type="OrthoDB" id="5529162at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="345"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="3">
        <location>
            <begin position="551"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="673"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="5">
        <location>
            <begin position="865"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1051" mass="115377" checksum="075F6EDCA9A58187" modified="2008-01-15" version="1">MCLGENVREVHIPVVFNQTVPASLTYSITDPVSGHKSVHTIKHPKTSAQTRARAPGTEAQEPDVPRGAHVLSLAERKRARQAAKQRASDMPVETVHDLRITHTGILQLESVVDRQANEALVGPETVTLVECPRASFVHGASDYCMGEEALVEVMLHGTPPLSLEYELLRGSEPRKQIQHQHTLLHHSPHMPATIALGLPLPGTQTVRLKRVRDACGNAAALQDAYDVQVHAQAQVHFDPMQCVPGRPLKLLRTSPGLDVRVQLQQAGPSDAWDVQVVHRPDGNATTTWKTLASAGGRSRQDVWTLERGTHTKRLDQTGLYTIEGLSSQFCAGQVGSPWTCEVVDVPLPRASIHFESIEDPCAGTVGVKALSDLEGEPPFRLVYETQRAGQAPRRHERVVRDQTRDELEFWPNMEGLVTYRFLELNDANYQHVPLDGPSFTQIAHPLASASFVGANSDQDAVVSSCGEPTVQADVAFSGTGPYSLEYSTRGGAGGEPVYWHVDNIEEARTTLNLTLPPNHQGRATVSLLRLRDGKGCERRLATRDLRVDVRRPNAAVGFARQHAVVQEHTYADLPLRLKGTPPWFISYTLDHGRENGTATLHDANEALRVSEPGSYTITGVRDAHCAGSVLPQQETAEVVMRPRPHAFFVDTTQPNGLKSGVVSLPPVCVSTPYTATIALQGQPPVEVKYQQTTLADSGTTLTRGNTLSSSEPNASVPLKTNVPGWFSYNIVSISDAFYPHTAAAAPALLEYRVWPRPDAKFVHDEPQRITACVGGTWERRPILHLFGTPPFQVDMVLRPVHIEGQAAPTRFAQTVHESTWHVMPPTVMSVPGTWELRVERVQDAHCVNEAATASVLVDVVESAGVVPVTNRMHYCVGERMDFVLQGMSPWTVEYTFLGRTSHVTARKAEFWRLADRPGVLSVLGAAHGSNTCRKTHAPIERIVHALPSAHVSAGANLVESLREGGHAEIVFTLEGEPPFSFTYQRTEPADTHARPKVLETHTVNQWQANEYRVPTSQEGTWSVVWMQDRWCQVSLGEVSGPASWSVSHESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUE3</accession>
    <name>A8PUE3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginine-requiring protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_0667</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732074.1">
        <property type="nucleotide sequence ID" value="XM_001732022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUE3"/>
    <dbReference type="FunCoup" id="A8PUE3">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUE3"/>
    <dbReference type="GeneID" id="5856380"/>
    <dbReference type="KEGG" id="mgl:MGL_0667"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0667"/>
    <dbReference type="InParanoid" id="A8PUE3"/>
    <dbReference type="OMA" id="HAWYELP"/>
    <dbReference type="OrthoDB" id="5585968at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000070">
        <property type="entry name" value="Acetylglutamate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="220"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="220"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP44860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="442" mass="49737" checksum="02BBAE2F492021B9" modified="2008-01-15" version="1">MCVPQRCSHKPLPSLQQPLSSHLEHDKNGAWTLEADTSIDSVYRALQHGHIPIIMPMAIRESMTDKVTMDTTKRTLRCICVDADQVMVTLSREMASQRLADELTPVRLMVITREGGVPSHARGGDPHLMINLSSEYESIRRSYVWDDTHPTALKNLAMIRDCLAYMPNMASGLIATHRSPQSLIANLITNKAAYSPSLPPRLLASRREMRHMPTVVRAGMPIRIVTQWHELDLARVQNVLESSFQRKLNADAYFARLKTHLDFVIVTGNYDGIAIVTREHAMEDPPGMPPIAYLDKFAMLPTLQGSGAVDFLWNALRDEVHGLGLLDALNNNGGHNGVGVGRDLVWKSRAVNKVNRWYFERSNGFMTLPGGPPHWYLFWCDAEDRLKQYAGEPIIAPGSRLDDVWMNTTPTSPMLPIIVPEEQGRWERWAKCLARIPSAWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUJ3</accession>
    <name>A8PUJ3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732106.1">
        <property type="nucleotide sequence ID" value="XM_001732054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUJ3"/>
    <dbReference type="FunCoup" id="A8PUJ3">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUJ3"/>
    <dbReference type="GeneID" id="5856412"/>
    <dbReference type="KEGG" id="mgl:MGL_0699"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0699"/>
    <dbReference type="InParanoid" id="A8PUJ3"/>
    <dbReference type="OMA" id="HVIDMVA"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013130367" description="P-loop containing nucleoside triphosphate hydrolase protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="54"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="275"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="74378" checksum="64A1619BAEB84623" modified="2008-01-15" version="1">MASWRGVARWRIAIALPLVTRFYEVRYYGVRMCTSGSVKLRPYQQECVDACIDALERKHLTRIGVSAPTGSGKTTMFLELVSRIFSREANTSHALILVNGITLAQQAAERAKRMFPHMTVDMDQGARHVASGEADITVATVQTLRQPKRLAKYNPHKFKCVIVDEAHHSTSPSYLSVLSHFHKAIVPSNKHGSTTDATTPIIGFSATFTRHDGVALGLVFEEIVFHKDFLDMIDEQWLCPVRFTLIRADFDLSKVSTTSSDYVVSSLAHVVNRPDVNELVVRSWMDLAGATRQSTLVFAVDVAHVHALVKEFQVRGIDARGIHASMRLTERESLLASFQRADFPVLINCAILTEGADMPGIDCVLLMRPTKSRNLFAQMIGRGMRKSAGKSDCLILDVVGNAHNDLVCTPTLLGLEEQNIASDEATVVDGTRHRYDTTRATVHAYTNKTFQASKSFLEPPEHVAFIDFDDVHELQKAMSMGAAKSVKELSPYAWVDCGADTYVLGSFDGAYVKVRRVDSEWHAHYYARNAAFWKDVAAGLTLNAPYFKRKVLASTDLGHALRGCDTFMNRVLEASNRSPMWLRRQARWRAMPATPKSRALLAQTLTHRCHTLSTPSISPSMTQGSLQRAMIRLRHGGKSLWRSAMKRHNRLHARKASQNVQVGPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUJ5</accession>
    <name>A8PUJ5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732107.1">
        <property type="nucleotide sequence ID" value="XM_001732055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUJ5"/>
    <dbReference type="STRING" id="425265.A8PUJ5"/>
    <dbReference type="GeneID" id="5856413"/>
    <dbReference type="KEGG" id="mgl:MGL_0700"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0700"/>
    <dbReference type="InParanoid" id="A8PUJ5"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="50" mass="5235" checksum="E87B8848B18C1220" modified="2008-01-15" version="1">MLLISSQPSNAYCQGIVVVNLAGPKGGGSLDFTRDIARHATGNDQECVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUK0</accession>
    <name>A8PUK0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732110.1">
        <property type="nucleotide sequence ID" value="XM_001732058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUK0"/>
    <dbReference type="FunCoup" id="A8PUK0">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUK0"/>
    <dbReference type="GeneID" id="5856416"/>
    <dbReference type="KEGG" id="mgl:MGL_0703"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0703"/>
    <dbReference type="InParanoid" id="A8PUK0"/>
    <dbReference type="OMA" id="HEVIHKY"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25453" checksum="D05792A40CA93E0E" modified="2008-01-15" version="1">MTKPTFPDPPKLDTLVLHADQPDETKDEAFPVAPSISMSTTFRQPHPDSTLARNADNLESAPDVAPYHVYSRYTQDTRTRAERVISGILGAHSLLYSSGLSASDSLLDFCLPSVIAIREGYFGVHEVIHKYCRGRNVKVIDLDDEYPVLAGVPAENESNISQGKLLVWLETPLNPTGEARDIEHYANRARAANGYLVVDATLAPPPLMDPFLHGADFVVHSGTKYLADIPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUM4</accession>
    <name>A8PUM4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732125.1">
        <property type="nucleotide sequence ID" value="XM_001732073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUM4"/>
    <dbReference type="FunCoup" id="A8PUM4">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUM4"/>
    <dbReference type="GeneID" id="5856431"/>
    <dbReference type="KEGG" id="mgl:MGL_0718"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0718"/>
    <dbReference type="InParanoid" id="A8PUM4"/>
    <dbReference type="OMA" id="ACDVNGK"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="349" mass="38000" checksum="2865C01143647F45" modified="2008-01-15" version="1">MSGSGRSLRLTFKGDKPKRKRSKIQSSTSARKRASTSVDDDESDVDMYGGDDQAWVSPGVCGEITGPCFVHQRQENGSAIVLSFNAPLTQVETSTVEPPALPAISGNGEEDNAFADGATIVASEVTPLTVHQVWVATNLPESQTWTFKSAQGTFLGSSSYGAVIASNEARGPQEEWVLRRVDPMASSSTASPGDGNDTVIPGPRAGFALQSKYGGWLATEDASSSADSRQRRRLVRADAKELTPACVWDVSVQWRFRHAYRKTQRATKVGTSSAASLVDEVQLARSRQGWNAGSWHQYAPESRRELLRAQREGRLAEAMLDRRSKLKSDKYTKVCSPMILVEVSLTVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUR2</accession>
    <name>A8PUR2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0751</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732158.1">
        <property type="nucleotide sequence ID" value="XM_001732106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUR2"/>
    <dbReference type="STRING" id="425265.A8PUR2"/>
    <dbReference type="GeneID" id="5856464"/>
    <dbReference type="KEGG" id="mgl:MGL_0751"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0751"/>
    <dbReference type="InParanoid" id="A8PUR2"/>
    <dbReference type="OMA" id="NIWSASN"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF218">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727089" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="629"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="563"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="703" mass="75849" checksum="F104FA65BE8B6DFB" modified="2008-01-15" version="1">MLGVTPFLLVLVALVASAVVSASDVSVARLSRELRKRDTASTDASEFNGKTFDYVIIGGGLAGLVVASRLTENPNITVAVIEAGTSGTAKNESEKILPPAANLYNSPGQTYMNWHYKTVPQPQLNNRVAPWPRGKVLGGSSAINGLYYVRHSVHEQDAWGDMIGAKDLWGWDNMYRAMKKSEAFTAPLDSVAQIDQISPNPDSHGMNGPINSTWPAVTYDCVGAFVNASSSVATPHAKDPYGGTNLGTYVATLNINPSNWTRSFARTGYYDPYVYRSNLHVLTRHLVTKIEFDTSGKQIKATDVKFKSDPNSDEYTVKAGREVIVSGGAINTPQILQLSGIGDKNFLKSKGIDVVLESPAVGYNLQDHISGGVEWHPKDSTKMPPSDTNESKEVNSYTNNGVAYVNGSQVLKDQWNSYIDQVKGNKSKAVDAYNGTDAAKKGYDLTYSTVLGVIQKNVATIEMLFSMAFGQVQVQSALQHAFSRGHVLVNSNDPFQAPDIDPRYFEQSSDLDMLRGAFKLAREVGQAQPLNSFLDQETHPGTNVTSDQDWDNFIRDRVGTEYHPSGTAAMLPQDKGGVVDKNLMVYGTSNLRVIDASVVPFVVASHFMSLVYGVAEVGAEVVLDAYKQSNSGGDGEKKDNGNAKDADGHSGGAASAGAKNSTGKSDSDNNAQDASSTLYTSSKVYSTILMSVVVAFFTFYISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUS5</accession>
    <name>A8PUS5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732168.1">
        <property type="nucleotide sequence ID" value="XM_001732116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUS5"/>
    <dbReference type="STRING" id="425265.A8PUS5"/>
    <dbReference type="GeneID" id="5856474"/>
    <dbReference type="KEGG" id="mgl:MGL_0761"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0761"/>
    <dbReference type="InParanoid" id="A8PUS5"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="94" mass="10666" checksum="89A88ED2D1718914" modified="2008-01-15" version="1">MPIAYARTASSLSARLRSPSPILSMARHALLPQRQMPFHIPQLGGVRFTTYGSEYQPSQRKRKRKHGFLARLRSRTGKKVLARRRAKGKTAVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUT4</accession>
    <name>A8PUT4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732175.1">
        <property type="nucleotide sequence ID" value="XM_001732123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUT4"/>
    <dbReference type="FunCoup" id="A8PUT4">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUT4"/>
    <dbReference type="GeneID" id="5856481"/>
    <dbReference type="KEGG" id="mgl:MGL_0768"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0768"/>
    <dbReference type="InParanoid" id="A8PUT4"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="231" mass="25822" checksum="55EE4EF4A380AF28" modified="2008-01-15" version="1">MCASLLVDPLAGHPTTFGNTGRIGQVVNLWSELTGFSDWQYELGVQIVDVCISTRSQNGGIITMDALIRGVLHLRHGKHSYCTESLQDNEWKISSSDIERSIKALEPLGCGYEVFDLQGIKMVRTVARELSTDSKHVLNFLALKHIAPRDYVGIPYATPESILSSTEKLKETKDAFWTKDRAAKTLEDMLMDDGTLWLDIVPNDTICGSSDYERKRYYAIALSEINSESTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUV5</accession>
    <name>A8PUV5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EB1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732188.1">
        <property type="nucleotide sequence ID" value="XM_001732136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUV5"/>
    <dbReference type="FunCoup" id="A8PUV5">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUV5"/>
    <dbReference type="GeneID" id="5856494"/>
    <dbReference type="KEGG" id="mgl:MGL_0781"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0781"/>
    <dbReference type="InParanoid" id="A8PUV5"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB1 C-terminal" evidence="7">
        <location>
            <begin position="157"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="98"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="275" mass="30270" checksum="54DB94F99534A527" modified="2008-01-15" version="1">MSRINFGAKHEYESLTNYKVLQNVFNKNRIDKPIPVERLVRCKMQDNLEFLQWIKKFWDLNYTGEGMYDAEGRRAGQPGTPAASSPGRRPASGAGGTRARPSVAAPRQSAASRPSVAPRPSVAPQQVRATGAAATGSSAGPRRMSMAPRAGTRGPSAAMISNETIQQLTAEIDEMKLSVDSLERERDFYFGKLRDVEVVLQERLGELVRPTEDGEELVNPAGASETDTLKQIQAILYQTEEGFELPDAAEVRICLAQSLTLRQMEPEPADDMETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV18</accession>
    <name>A8PV18_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP45011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732225.1">
        <property type="nucleotide sequence ID" value="XM_001732173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV18"/>
    <dbReference type="GeneID" id="5856531"/>
    <dbReference type="KEGG" id="mgl:MGL_0818"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0818"/>
    <dbReference type="InParanoid" id="A8PV18"/>
    <dbReference type="OMA" id="VAKLEWL"/>
    <dbReference type="OrthoDB" id="3267068at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="393" mass="45042" checksum="B4CCC362E3EDCAD7" modified="2008-01-15" version="1">MSDYLSFSERSMKWPPMFGRVPYERQSKSSDEQGERKILNDALGFTQRPHIQSILTPLQRPVGIPRLQSRVGAPFARLYAPELAQYDVPMEEFVEFIDNMNIVCADFVPLQILDAVGSLVGLVPNHWAQMAGAVTSLGSKVAVHAVSKIRGETFLRRVNSEYFNPRGLSVQMCTTDALVRLGHVPPEAAKMPPLDHVTATMSIEERRLSHLMPWLSPVTDQVPAPSPQTNKLKELCNKQAAYTSRRTQRKVMDDRFDAFEKQGPSPAEADQMFATLRAKGEFTPRQIGKMEKKYMKGERERSKDQRDYEKEKSKIEREAEKDIMKAHRKGKIEDLVKAERKRESELGKLDREYSSEQLKRQRSFEKEDKERKKGHKAVWLLVQTISQVPTLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVE1</accession>
    <name>A8PVE1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731571.1">
        <property type="nucleotide sequence ID" value="XM_001731519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVE1"/>
    <dbReference type="STRING" id="425265.A8PVE1"/>
    <dbReference type="GeneID" id="5855868"/>
    <dbReference type="KEGG" id="mgl:MGL_0839"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0839"/>
    <dbReference type="InParanoid" id="A8PVE1"/>
    <dbReference type="OMA" id="FWNIVPG"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33765" checksum="7C7F84E2C2D0CC74" modified="2008-01-15" version="1">MSASATNRRVLRNLDHLKQGTNQKFLNKLRPSYAQSTPAYVQPKDRVAFWNIVPGDTVKLRTGAVGHDDEGRPIRGEGIVTTVDRTTNRLFLRDLDDQHKLAPKNIKHVIPRLVDPEAGEEKGYSGNVMSVPRPVHYSKVMLKVPNTNSYASRIVRSKPFYDRHKGMFLWKRFAIVKATDEESIRSGQVVKKVEVPWPKVPERRRPFQITHADGRTVEEETWVPWVPEDPVLLPMRKPRTTPVREALAAERKTVWDAKLAELRAKAHDLTLSTPAGAHSYAGFVRTENVRPPPIAQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVQ7</accession>
    <name>A8PVQ7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B-block binding subunit of TFIIIC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731663.1">
        <property type="nucleotide sequence ID" value="XM_001731611.1"/>
    </dbReference>
    <dbReference type="GeneID" id="5855968"/>
    <dbReference type="KEGG" id="mgl:MGL_0931"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0931"/>
    <dbReference type="InParanoid" id="A8PVQ7"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="151"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="640"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1312" mass="144182" checksum="B6ADB0204FFF5FA8" modified="2008-01-15" version="1">MLSRLLQHCIHEVAMDGDEGTDTERLFSFVEAFCRALPQDMQPNLDAPYRAFLWRHLLMDSRIHAGIVRGRAQERTGEQASGTKKPDAKRQSILAKGRASEPLLLTPTPIAYEPLDALVKKHGPDRLRVYVDAEHVRRTLTGSDAPFVSAAAYTALQLVFRARERGLTVVDIGAATQYDQKTVYYLVKVLVDRDLVAKFAAPEMGHVSNYVVGRPFLEQNPQWRAQQNALGTDTDPKHAVDLVGMPSWVDVDVIATQEEQRGDADDERDESVLSLTLPPVMNPHEGEMLAFPMLTEEQSSVWLHSRQDLLSLRLLKMFAQSPSHMTPRRWLATRLGLRRVPTLRRGFLTFLNQRVSAGYLERVRVQLGSTTPLYLRATPLGLERQFTLDAGAEAAGESLSSVSASEQEPMLVLSVAAPLERQLLDHVDACGKGGCTMNELAQHFCFSSEVKRMVEQILSRQVSQGPPPYAPLSICAPFEQEGRERRIRYYTARGFAEKCADEGLSMSVALGYDVPSDGSVPNVPDSLPGECMFESADALCTAMQHVRTHTWGFFRDVCGPVPLRGTKRRANVDPSTGRSKRGRPRKDEVRVKQETAASETTPSDSRAHVSGHRSDAHRPAAPEDAVDECGASEPVAAAHLEPAAPTTRQHDAQAVPERPSSSAAAPARPKSEATNAVPIDPALCASEQQGLASSAAAMTTPSKSARRLAPLSARASRASEARTNLSSFQRTTLLAHVLRHHGGAVDEVDIPRRTRECLDKTPMPGGDLSDRTTRAKTIQHAIKHGVVKVVKLPRPDDPQRPRSIVHLADLVSDALQMALETATKPPPPASTPTTTLAATVPMLHAASTSGATAATASMSHDSACADDGSAAHAPIPMPMPVPPLTQRSTAPWTDTAPVTYGQEGDPMNDPATHHAFARHSYLLRQYYGFPHGSAARLALFLEAARASAMDGHEGSSRGDGRQIIDLSWFITACPLRTFVALVPVKLHTPAVVRAVMGASVRVDQVPMHVSTRLGLRRQSAHRQRFLAYVMQLEELGLAERIPRASRKHDVDHASQDNAAAARDGSMWALVDDAPVFRWPREHVQTMSVRTPEERSQYWAAVREAVQTSEPRRVPVYLCAPHAWRDTFSLRGVQKAFLKRYVHAVPPMEGIRRLASTIFAPVDAVESFFASHHAQAHRTTATIAHKVEARRKQRADEWNAALADVQAMGPPDAAMPRALQQLEKRYVYGRDAMDAPTLRKRIAAALGMQKKRVPKAAPVRRTRRRSSAIWTPGHQDLFRDAYVIVTDRQEACGVCIWHVVSMSLLMIGRLCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVS5</accession>
    <name>A8PVS5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731676.1">
        <property type="nucleotide sequence ID" value="XM_001731624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVS5"/>
    <dbReference type="STRING" id="425265.A8PVS5"/>
    <dbReference type="GeneID" id="5855981"/>
    <dbReference type="KEGG" id="mgl:MGL_0944"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0944"/>
    <dbReference type="InParanoid" id="A8PVS5"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="124" mass="11598" checksum="BB34E5D0D381F151" modified="2008-01-15" version="1">MSEADDLYADLYGEEAEPSVSAQAPDASKTETPAAPAAPSAGGSSTGTAAPGATVAGGTGTAENHSGPAGAAPAPAGPAASAPTAGASFIPGRPAPPPQDSAEARSAAAARGEHIAPQDLPDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVT2</accession>
    <name>A8PVT2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 10">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0949</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 10"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731681.1">
        <property type="nucleotide sequence ID" value="XM_001731629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVT2"/>
    <dbReference type="FunCoup" id="A8PVT2">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVT2"/>
    <dbReference type="GeneID" id="5855986"/>
    <dbReference type="KEGG" id="mgl:MGL_0949"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0949"/>
    <dbReference type="InParanoid" id="A8PVT2"/>
    <dbReference type="OMA" id="NRYTDLN"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="380" mass="43258" checksum="E26EEF4B49A08217" modified="2008-01-15" version="1">MADFVKLSIFGTVFEITTRYENLQPVGMGAFGLVCSGHDKLTDTSVAIKKVMKPFSTPVLAKRTYRELKLLKHIRHENIICLSDIFISPLEDLYFVTELLGTDLHRLLTSRPLEKQFVQYFLYQILRGLKYVHSAGVVHRDLKPSNILINENCDLKICDFGLARVQDPQMTGYVSTRYYRAPEIMLTWQKYDVAVDVWSAGCIFSEMLEGKPLFPGKDHVNQFSIITELLGTPPDEVIRTICSENTLRFVQSLPKRERIPFHQRFPHTDREALDLLDKMLVFDVNTRISAGDALAHPYLAPYHNPADEPVAEEAFDWSFNDADLPIDTWKVMMYSEILDFHNIEEVPANEAQMPAQASGPAPALPQAQPMPSAYHSSMHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW85</accession>
    <name>A8PW85_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sec1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731778.1">
        <property type="nucleotide sequence ID" value="XM_001731726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW85"/>
    <dbReference type="FunCoup" id="A8PW85">
        <property type="interactions" value="702"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW85"/>
    <dbReference type="GeneID" id="5856083"/>
    <dbReference type="KEGG" id="mgl:MGL_1046"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1046"/>
    <dbReference type="InParanoid" id="A8PW85"/>
    <dbReference type="OMA" id="VNDLRAW"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="75248" checksum="39CFDFE3A0315260" modified="2008-01-15" version="1">MAPSGANMLGSTGTRSVSLRSAQVQSLLSMLNFNDPAFSHTTGRSSVKPDESMPTVAAPPVWKILIMDPTSTDILATSLRVQDLRENGVTLHLQLHSDRPALPDVPAIYFVSPTNENVARIAKDVSQGLYESTYINFTSMVSRSVLEQLAQGVARTSGAGAQIRQVYDQYLDYIVLQPNLFQLLPKGRESNSAAAASSHIPTTYEQLHNPQHGQEHVEAETDRIAGGLLSVFASMGTLPIIRAPRGSAAELVARKLESKLRDQSSASRGVAGLFAATSNSWNKERPVLVLMDRNVDMVPMIAHSWTYQALVYDVLDAKLNRVTVQESDKPVAAKRSYDLDAKDYFWAKNAELPFPQVAEDIDAELNQYRQEANEIMRSTGINSMDEVGQLDASSNASHLKAAVTALPKLTARKRTIDAHMNIATALLQGIKTRGLDELYQMEEAITRQSKSAILEALQNPAMQNPEDKLRLFLVYYLSTPDASLSRKEVEDFEATLRAQGVDLAALMYAKKAREIMRFTLSTPTLAPTQGGHELFRGFGSLSSRLTDKLKDSRLEHLVAGVKNFLPVQKDFTVTRLVASIMDPAGSNAQTLQETDDYLCIDPRQPRGRGTGMAPGGAKARQPFAHAIVFVVGGGSHVEFANLQEYVTRSVSVSGGIAPGTSSQKKITYGSTEILTPSEFLRTLAVLGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2024-01-24" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWB9</accession>
    <name>A8PWB9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731797.1">
        <property type="nucleotide sequence ID" value="XM_001731745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWB9"/>
    <dbReference type="GeneID" id="5856102"/>
    <dbReference type="KEGG" id="mgl:MGL_1065"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1065"/>
    <dbReference type="InParanoid" id="A8PWB9"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="76" mass="8764" checksum="293546CAB3E430FD" modified="2008-01-15" version="1">MELITADDDLLSCMLVDSLEFDPDIVTHKMNPAFRPMRFDRSAVCRMIQQFVIWEQDPSKAVASLCQYVRATMGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWC4</accession>
    <name>A8PWC4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor SPT6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Chromatin elongation factor SPT6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1068</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731800.1">
        <property type="nucleotide sequence ID" value="XM_001731748.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PWC4">
        <property type="interactions" value="720"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWC4"/>
    <dbReference type="GeneID" id="5856105"/>
    <dbReference type="KEGG" id="mgl:MGL_1068"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1068"/>
    <dbReference type="InParanoid" id="A8PWC4"/>
    <dbReference type="OMA" id="GYFYLCF"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1144"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1504"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1504"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1518"/>
            <end position="1537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1544" mass="173470" checksum="8E8E20FD50EC1478" modified="2008-01-15" version="1">MAEDARKRAADDDDDRVDSQSEEEGEDLMKESGNLVGMDSSDEDEDEDENEEEQRRVAEGFIVDEDEEEGDKERAHKRKRRHKHHREVDEELDEDDLALLSENTRPEGAPHKRARPASDAQRTDDLAHIFDDEEEDERGEGDGVSGAQPADYYDDGLDDFIEDDEEDAEMGGLNEEEREARRQERLEERRRARMSGARLDPRKAGMDLEAWDEVHDIFGNGEDYAWALEADDEPAEEGKERMEYKDIFEPAQIRERLLTEDDERIRQVDIPERLQLMMPGHEGLELLERKLTDAELDDAAHWASTRISTRCTAEFLDEFAPHSRLRTEWHACVRQMLAYMLNDLLEVSFLTQHRLDELEYTPIEAGAPSAHKNAATTTLLVRQELLTLHTLGIKYKLLLSRKDSLRSTFSELEATFTDAPVDGSIDIHAVRSTVEDLLVQASTLEEVTDISEWLAMRFGERFREATVLAKGHETQTLKRPTVVSEYDQRKHTPMAQLAARLGLTSTQLAANVAGGIKQFVPDDDESAPLTVADEFIGAAPGATTAEAALALARTLLAHEIGKEPALRREVRTLFRTSALLDVEPTERGMTRIDEAHPYYNFKFLRAKPVHAILQNASQLLQIVHAEEERLVHVTLRLPTDTANKLEQRLQDQFVSDGVSARSQAWNDERRAVIEEVCASFLLPLGRAWTREWLLEECREALLRQCEQKLTQRVEGGPVQSAGMLSRQGDPEWDEQVSHVPRVLAVSHGSGDPRTSKVVAICLDEDGHLIERVTYDTLRPLRGAAVEAGDDSDVQEDPRAEFTKLVRRRHPDVIVVNGFSAHAQELKAIVQDLVSSAYEERVREEGLEGIAAEHARMDVVSVYDDVARLYQHSARAAEEFPELSVLARYCVGLARYAQSPVNEFAALGADLTAVQFDPAQRLLPTERLRVCLERAIVMLVNDIGLDLQIALTNTYVQHMLPFIAGLGPRKAQALLNAIRTRLDGIVVNREVLVRRGLLSFVVWNNAISFLRIDQDAAADALDDDAQPDVLDTTRIHPEDYDFPRQMARDALNKHEEDLEGEHPSLACAEIMEDARPSEKLAALDLDNYATMLWERRGLRKRLTLLTCKQELIRPYDDWRPPQLLPTTEELFMMFTGETRRSLSEGYVVPVIVTRIEEGRDIEGVLRVRLEAGIDGVITGRDIMPGYNSRDVRLRRLFRSGQALNAVIVQLDLQRMRAELSLRAEAFEYVNPAQGHTPVDPMYFDHERAQMANDAADERARRRHQTRIGRRVIDHPNFHNLNAVQAQNFLATQPRGSVVIRPSSRGMDHLAVTWKVDDGVYQHIDVLELDKENDYALGRILRVADMGSYADLDDLIVNHVRPMAAMVEMMMNHEKFKGADERALHTFLTNASLANPNRSVYAFGLNKQHPGYFDLAFKANSQAPIQSWPVKVLPGAFKLGQATQLADVAALTNAFKTQYMAQTNPMRGDRTSAPHGGMTPAYYGGRTPGRVGGGMTPAYAGGGATPNYGLTPGYGAPPMYSRPPPGPPPAMPGPPPRGPPGASSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWI9</accession>
    <name>A8PWI9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731848.1">
        <property type="nucleotide sequence ID" value="XM_001731796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWI9"/>
    <dbReference type="FunCoup" id="A8PWI9">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWI9"/>
    <dbReference type="GeneID" id="5856153"/>
    <dbReference type="KEGG" id="mgl:MGL_1116"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1116"/>
    <dbReference type="InParanoid" id="A8PWI9"/>
    <dbReference type="OMA" id="QRPHYRK"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="206" mass="23277" checksum="9362F0FF47FAB044" modified="2008-01-15" version="1">MGITRDSRHKRSATGARHAYYRKKRAFELGRQAANTRLGPKRIHDVRVRGGNIKPRAMRLDSGNFAWGSEHITAKTRILGVVYNASNNELVRTNTLVKGAVIQIDATPFRMAYEKHYGQPVTKRRVPGAAPMEEVKRSNHVERKLAERRKDGKLDPLVEQQFAAGRLYAVIASRPGQSGRADGYILEGSELEFYVRRLRSAKSKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWK6</accession>
    <name>A8PWK6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731865.1">
        <property type="nucleotide sequence ID" value="XM_001731813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWK6"/>
    <dbReference type="STRING" id="425265.A8PWK6"/>
    <dbReference type="GeneID" id="5856170"/>
    <dbReference type="KEGG" id="mgl:MGL_1133"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1133"/>
    <dbReference type="InParanoid" id="A8PWK6"/>
    <dbReference type="OMA" id="YEIHANP"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="5">
        <location>
            <begin position="70"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="5">
        <location>
            <begin position="193"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="6">
        <location>
            <begin position="760"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1257" mass="140914" checksum="DC41893878B65803" modified="2008-01-15" version="1">MTDPGSDVRVPITYATHSASQATAQLAHIVPLLAEQFPLRNLHWRPPVTMQTLRPLKRSSGSSGMDSVPALRTIQNLNVELIPLATHLPNQQNVQILERVPCVHIFFVTCDDIDVYRAQVRNEIRHWLATLRKHIPNDFDHLSTIRSDEQDKAGTALPPEHLIVLLPPPSSGVFTASSATSSGKSAMGRFYTMNKGTVLEKLRADFNSSAKEHVLALSKLPTSSKDNDPALWIDIIAHIKTCTLASLGRVLDMQDRVVSMYDESTKGVNWTLSGSITRKEFVIQTLEGLGLLHDVLHIYDTVETHLERCIADGRTPFVPGGNEPGDDSLMLLGPLRKPYLSLMASNRLSLFDIQCYLYARRSTVHAALGEVVQVMQMTPAFIASVTRMLRPHRHLLAQAFLEAWSFSVALDAVEQCQAWLVEAQGETDDVRTTHAFHAAKAELLELAVRQLISIGLQSGHLPRVEPFQFVASDSLSMFAPDARITRKELVEAMAHRHVFESQLCNVIHRTLLAAVLCQQTPRTLRLKYLFACFHMSRSSFHHAHALWDELLAHPALPYSAVLYGPTHSQYLACLQAEHLAHGDVWIQALVAAIQAISTLRAQPLSPQPMDEMSLLTWLADESDNQHTYATLVGYNGCRVHVRSVRADRDGAHTFLDIDLLSYLPKPLSVDAVHIWVANYRQVQLQFSASAHTLEPGLNRLRLVCMTSAVGYFHLQATQIQFRRVLLESIVQSAASLSTLADAQQLEYRRHRICIPADGAALQMHVSMPRVMSLQDARSVELHLDSGRDPLEEATISVTAHGDVRLKLDEDPCLACDNGETSVSRTESGSLLLRHLPARTSCTMALPVSYMPRTPYIELSIVVYFQRNGYDCSVHRTLRAPLHLPFSINIQDFFRLHHLLSKLSLETTAGTHVRVCTPQVTASEEGPVSIQVPVQSVPLRMRPREASTFLLQFQYKYLGTRRAANPPFALSIVYRTAADEAQGLALYYLSLLLAQTPSWMDGDQQLLQRALCECLEHATFDVGSTPMYEAKYWHDTLFRWGWPQESQRSIQVLELVRRVFARLEDPSMDAMLIPTTAPSHVQQNAAQQHAWEASQKCLQWRTLTLPLDVPFVDAVNSVSILAPERSHISLGEPIDITIDVTISLVWSQASDDDDVSTVLQYNILTDFDNWLVWGNKKGMWEIPAQQLESHHTIHATLLPVRTGWLLYPRIRIAPIGPAARPFRCETYMRQADQGIYVVSSSHPDTYWVDLRPVEIAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWL1</accession>
    <name>A8PWL1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731870.1">
        <property type="nucleotide sequence ID" value="XM_001731818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWL1"/>
    <dbReference type="STRING" id="425265.A8PWL1"/>
    <dbReference type="GeneID" id="5856175"/>
    <dbReference type="KEGG" id="mgl:MGL_1138"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1138"/>
    <dbReference type="InParanoid" id="A8PWL1"/>
    <dbReference type="OMA" id="HTREHAF"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="369" mass="40408" checksum="9A0E2492A9A527C3" modified="2008-01-15" version="1">MSLVLPTFNKTSSVSSTAQSTSSSASTNAPLSPTVSGTISSPSSMPVSILPAESNRTRQAGAVLISILFKSTIPWVWITSQRETTAQIFTYMPQIIAHAIQCDASDVSTVQLKRFSPANSPVDIDINAHFRTLYMAYLPKPKSRLLSNLIHDVNSLFYDPDGGIVPQQIVREVDPSFNLFEFSRNPDDAATGSIPEETRDALVGSFVGVGGAVTLGLLIWLVQRHIKQRKANAARRASRTDTILSFGNDSPDPYLDGIEYAQPPQQMRSFFVGDVSGNPSDSVFEHQQGITGVLDVNQADNPYHSEHDPQSRDVDSNRSDHDSHYAGLEIPVPTTNKPAYGGVTKPKHMLSMPEHSMRIENSSYFPHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWL9</accession>
    <name>A8PWL9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731878.1">
        <property type="nucleotide sequence ID" value="XM_001731826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWL9"/>
    <dbReference type="GeneID" id="5856183"/>
    <dbReference type="KEGG" id="mgl:MGL_1146"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1146"/>
    <dbReference type="InParanoid" id="A8PWL9"/>
    <dbReference type="OMA" id="PYVPVRR"/>
    <dbReference type="OrthoDB" id="6288785at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22673">
        <property type="entry name" value="FHA_Ki67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="977"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1169" mass="128057" checksum="9743B4A5F43B040A" modified="2008-01-15" version="1">MPSRNGGSSAPSDAVLGVLQLLSEDNKEMHRYNIHKTTTTMGRALTNDVRLLLEDVSRQHCTIEFCEENDAVLHVLGSNGVWHNDVHMKPNTSDGKRIHLANGDKVKISAHTLLFSYIQRQPKPLMTEGLARSEATAGLAALAKSPPTTPRRQSARLRARASMPSLPTAWTPQLAKRPIPLVQQAHISQMSTTPDAQIAQGLRAYSAASKSSETEPGTPKATKHKSSPAKPNSINASTSTQVGHATQRSPSYNISKQEVLDTEIPEGPSQPVVPSRDSENNDSSDSCGIASVQSSLMARSTSDPDEAPQKNANADAMNETSSESSDKTMALDSLNESVKNRSTEQVHSQLTTSPAFPVKSQKANDSMETDDMSHASGQARPSCWNQPSTSDETDSSAPVLAPSELPGQDIMTSISKPTSNNQVQLSTDTHVPSETKSPLPMQDASDQHTPNPEHKNLESSQSSAMPFERPESDLTLCFDALEEAQQDAQPPVSSTPLTTSRYPQSSSLTSRSAMPITWSPEKTRKVSLRTATLLKRSSQYPIVPLSPVSANVPTSPSTPPKSTPPIQYPTSTGSKDMDLSLRHTSEMMMTSSDEEDEAEVESSFELQIAPKSPEAISLQRPNTAPFLTPQARRMEKPVVTRRLSCADPTSPRRPVPALKHRSSWVWLKDLLSPSKKVQQPIDVPELKQEIESGETSAPEAQRHAWKATDESPSHEESALTQEQKEKIRCPFEVPKDNHQHHVSKLTDENATAKELVCTESHKETASKPVESHQHQEDEKHSRLERHTQSEQAIQQALASSPLSSTEGWRKQRILTEMMPKVDHARQSEQCHEKQSKDLHLDHEEEFFDASHDVQDLNVEPKTLLVTTSGQDASVLSGSLVEAETRQASGHVPQTPDMRDLKHMFAEPKYVVPMESAMGNFRHFMNKQEQQQRPVSDVSLSSAWTMIETGHCEDDRHSLQRAHNMPPSQRTVVTANGPITSPTTGPTPETVPIMAHVPGQGTLANEPSEARKRVASALKQQDPSSRKTSLPSTSKPEKTQETRQPPVMHHHTDTSDIMKHRVTRSVPKKEPYVPVRRQLPPRNAVKMSRIGSLSTSATRGAGVENGTAAPRQARPLAPTTRGNTGVNTTRLPATSSSSTSSLPIARGTRLANMRTKSQRSDTGPSSMHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWQ4</accession>
    <name>A8PWQ4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maf-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731913.1">
        <property type="nucleotide sequence ID" value="XM_001731861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWQ4"/>
    <dbReference type="FunCoup" id="A8PWQ4">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWQ4"/>
    <dbReference type="GeneID" id="5856218"/>
    <dbReference type="KEGG" id="mgl:MGL_1181"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1181"/>
    <dbReference type="InParanoid" id="A8PWQ4"/>
    <dbReference type="OMA" id="CELFHER"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18771" checksum="553EC2E7F140E0BB" modified="2008-01-15" version="1">MAFEYPVETASEKAKEVYVRLVQTDDHNPPDLVIGADTVIVYDGEILEKPVDKVDNVRMLADLCGRSFHVITGVALVHPILSAPGYQIRTVCEQTKVHFADVPAPLLQAYVESGEGLDRAGGFAIQGRGALLIRGIEGDYNNVVGFPLYSVFDLLHNLVENEELDLEGMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWR4</accession>
    <name>A8PWR4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1191</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731923.1">
        <property type="nucleotide sequence ID" value="XM_001731871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWR4"/>
    <dbReference type="FunCoup" id="A8PWR4">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWR4"/>
    <dbReference type="GeneID" id="5856228"/>
    <dbReference type="KEGG" id="mgl:MGL_1191"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1191"/>
    <dbReference type="InParanoid" id="A8PWR4"/>
    <dbReference type="OMA" id="VRKKMWW"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="140" mass="15260" checksum="3AACCFED037776BB" modified="2008-01-15" version="1">MNEGSSHYDPYIPTESASKPVGNGAGGSRTAQIQAQIDETVGVMRDNINKVNERGENLNSLQDKTDNLAVSAQGFRRGANQVRKRMWWKDVKMRMLIVVAIIILLCVIIIPAAVTTTDKNSDNDSKQESSSIQPSSTATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX42</accession>
    <name>A8PX42_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731135.1">
        <property type="nucleotide sequence ID" value="XM_001731083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX42"/>
    <dbReference type="FunCoup" id="A8PX42">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX42"/>
    <dbReference type="GeneID" id="5855436"/>
    <dbReference type="KEGG" id="mgl:MGL_1318"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1318"/>
    <dbReference type="InParanoid" id="A8PX42"/>
    <dbReference type="OMA" id="MFAQATV"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="6">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="538" mass="57819" checksum="36221AAAC387DCEE" modified="2008-01-15" version="1">MSGLLGKVVRIDSEGAAPSLASLPEVASQVASQWKTSRASTVKPGECRLLFPAQSHPIAGVASGEQPRAPQTGPDSLPPKNVFLRNERLEWTRLAAAKGVRALRELGKINGEKQVIEVDSFSSSHAAAVGAILGLWNVNHFKTRGPMPGWDLPLDKQGGRHISVAPMNGLASQDEKKSLRDEDDDLCSTGTPLSWYTGEVYAHAQNWSRELQEVPANLMSPTIFSERVVNAFKNVPHTQVVIRDAKWAREQNMNLFLSVAQGSEQPCKFVEIHYHGAPEHHSAPLALVGKGITFDTGGISLKPSAGMDLMRADMGGAAAVVASTLAIAQLGLPINVVTVAPLTENMPSGRATKPGDIFQARNGLTVQVDNTDAEGRLVLADALSYVSETFSPHTVIDVATLTGACVMALGDVYSGVFTESDSLWHQLKTASEAEHDLCWRMPLTDMYLPQISKLNADLVNTGGRPAGACTAAIFLKQFVHGLEDRTKGEEQCVQYAHIDIAGSMEAASNTLNDYQAKGLTGRPVRALVEFARRLAYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX81</accession>
    <name>A8PX81_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731174.1">
        <property type="nucleotide sequence ID" value="XM_001731122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX81"/>
    <dbReference type="GeneID" id="5855481"/>
    <dbReference type="KEGG" id="mgl:MGL_1357"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1357"/>
    <dbReference type="InParanoid" id="A8PX81"/>
    <dbReference type="OMA" id="LETICYQ"/>
    <dbReference type="OrthoDB" id="3359458at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="184" mass="20955" checksum="DFCB7CAE50FD4430" modified="2008-01-15" version="1">MLAPAPRGRILAIEVLIVTSFPQTTQLLIVVKTTRFDDGHVMAWYIEQDGLDYCWPTRTRLDPSLLHTDTKHNSSLGVMFRKSLVMAARHLCLDELEMICLRAPLPDSELGEDQYSWCFDVLLTLERLQCLAFGQTLALEEDICKLRLSLLNQEHPSVAEVMDTSFPKLKQETDTSKRTSVTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXA2</accession>
    <name>A8PXA2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731195.1">
        <property type="nucleotide sequence ID" value="XM_001731143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXA2"/>
    <dbReference type="FunCoup" id="A8PXA2">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXA2"/>
    <dbReference type="GeneID" id="5855502"/>
    <dbReference type="KEGG" id="mgl:MGL_1378"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1378"/>
    <dbReference type="InParanoid" id="A8PXA2"/>
    <dbReference type="OMA" id="SANLECV"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="159" mass="17134" checksum="A363F9A939535EFA" modified="2008-01-15" version="1">MPGKILFHAARSDNLELLNSVLHAQPPIEYDINGVDGLGNTVLHYACEAVATHVLDAVLDEAIDVDATNRIEGNAPLHIACQIENEEARNWVVHQLLDAGASTTTLNHAGLRPMDLVVGARAETPLGKELIQMMTMSQAENALGADDIAYGAYLQKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXI5</accession>
    <name>A8PXI5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731272.1">
        <property type="nucleotide sequence ID" value="XM_001731220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXI5"/>
    <dbReference type="GeneID" id="5855579"/>
    <dbReference type="KEGG" id="mgl:MGL_1455"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1455"/>
    <dbReference type="InParanoid" id="A8PXI5"/>
    <dbReference type="OMA" id="RYWHLKT"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="139" mass="15540" checksum="7285EB087049DE46" modified="2008-01-15" version="1">MFRATQTTLSKASRLPLNSKKANKDFYKGTRAANVLMRKRIALSDPKGNQLFDEQGRPRTWNLRTHRLDEMRMVSYVVPPGLADTQLKPYVYLGSTSEGGTERPLPGQPGAPKMPAGGMNATYYSRLVDRALLSKPTRN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-10-13" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXR7</accession>
    <name>EFGM_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="1">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="1">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MEF1</name>
        <name type="ORF">MGL_1509</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This protein may be expected to contain an N-terminal transit peptide but none has been predicted.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731326.1">
        <property type="nucleotide sequence ID" value="XM_001731274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXR7"/>
    <dbReference type="SMR" id="A8PXR7"/>
    <dbReference type="FunCoup" id="A8PXR7">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXR7"/>
    <dbReference type="GeneID" id="5855633"/>
    <dbReference type="KEGG" id="mgl:MGL_1509"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1509"/>
    <dbReference type="InParanoid" id="A8PXR7"/>
    <dbReference type="OMA" id="GQFAKVQ"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000385575" description="Elongation factor G, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="34"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="136"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="190"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="777" mass="85901" checksum="4B2E2A9CE0AACDD1" modified="2008-01-15" version="1">MNRIASYLRTYATEAERPMATDVQPSESDVERLLRQRNVGISAHIDSGKTTLTERVLYYTGRIKDIHEVRGRDEVGAKMDSMELEREKGITIQSAATYCNWKATPPTERSNMTGDAADESTVTTQKKHDYHINIIDTPGHVDFTIEVERALRVLDGAVLVLCAVSGVQSQTMTVDRQMRRYSVPRLSFINKMDRAGANPWRVVEQIRTKLRMPAAAMQVPIGAEDNFQGLVDLVRWKAVYNEGTKGNVVRESDDIPADVLELAREKRQELIEQLSDVDDEMAEIFIEEREPTIEELVAALRRATVACRFSPVFLGTAIKNKGVQALLDGMCAYLPNPMEVRAIANDTAVAKKIAAQANEEGHDVAAMQSSAQHGSEVQLVPATEAPLVGLAFKLEESRFGQLTYMRVYQGILRRGGIIFNSRTGKKVKVPRLVRMHADDMEDVQEIGPGEICAMFGVECSSGDTFTDGSTTLSMSAMFVPEPVISLSLTPEGKDTSVNFSRALNRFQKEDPTFRVHVDSESSETIISGMGELHLDIYVERMRREYNVPCTTGKPRVAFRETISQPAKFNYTHKKQTGGAGQFGRVIGYIEPMTVDEDTGKDTAFVNSVMGGNIPPSYIPACEKGFADGLEKGALAGYPVCGVRMVLEDGAAHSVDSSELAFRIAAHAAFREAFRAANPTILEPKMSVEVIAPVEFQGTVIGALNQRKGTIEDTEVREDDFTITAEVSLNDMFGFSSQLRGLTQGKGEFSMEYKKHEPVMPNVQADMEAAYKKSLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXU9</accession>
    <name>A8PXU9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731347.1">
        <property type="nucleotide sequence ID" value="XM_001731295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXU9"/>
    <dbReference type="STRING" id="425265.A8PXU9"/>
    <dbReference type="GeneID" id="5855654"/>
    <dbReference type="KEGG" id="mgl:MGL_1530"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1530"/>
    <dbReference type="InParanoid" id="A8PXU9"/>
    <dbReference type="OMA" id="MHISRIF"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="206" mass="23193" checksum="C09C29B2949D1473" modified="2008-01-15" version="1">MDDTPTTSKKRGRRADATTPVDMAEEVDDELVAWPSSTSKKGNKRRKSEPNRTRERSSSTRATSVDTTRRSASRVPDSADTETDARKDEATDDDRDEDDGDDDSDMADGDALADDEFSRQQAIYAAQQRSMGYVYIGRRLCRMHIDLHALQHTHTHAHVSLRTSLYSLLSHLMDDDQLERHMASRRGTLNKGGVRKVCMSLFVQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXY1</accession>
    <name>A8PXY1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tudor-knot domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731367.1">
        <property type="nucleotide sequence ID" value="XM_001731315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXY1"/>
    <dbReference type="STRING" id="425265.A8PXY1"/>
    <dbReference type="GeneID" id="5855674"/>
    <dbReference type="KEGG" id="mgl:MGL_1550"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1550"/>
    <dbReference type="InParanoid" id="A8PXY1"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor-knot" evidence="2">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="163" mass="18851" checksum="8FB7F2D71213E4C9" modified="2008-01-15" version="1">MPPRTASKNVKADQEEPPPKYEGGEYELKDVVVGAKLYVEKINSDTGEWEQRLAEVLSIREKRQNRLHLLQEIQEKGEHAVKEKEPELDFYVHYCEFNKRLDEWVPSAKLVLSREMEWPRPPESSSSNKNTKRKVVQGVRSVQGTPTRATTPALRRVRRSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY41</accession>
    <name>A8PY41_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731403.1">
        <property type="nucleotide sequence ID" value="XM_001731351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY41"/>
    <dbReference type="STRING" id="425265.A8PY41"/>
    <dbReference type="GeneID" id="5855710"/>
    <dbReference type="KEGG" id="mgl:MGL_1586"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1586"/>
    <dbReference type="InParanoid" id="A8PY41"/>
    <dbReference type="OMA" id="VMDLYPC"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="648" mass="70507" checksum="B1B803D68E5E2A50" modified="2008-01-15" version="1">MDTLLAAYVHDTSLDVSHLPARLDAALLARQLMPAPTRPVYPNVAAWVQHYASSAACTNTAVEYRDSFSSTDISTLSFAELHLQSAKIASWLLRFAPRSVVGVAMPRSLSTYICLLGILRAGLVYLPLDESLPHVRCDQLLRDSGAVLVITAEDHDPAAPWPCDRARPSDMISEHGPDMRPIDANDPAYILYTSGSTGHPKGCVLSHANLAYAIDNFRHAFGSVSWHNARFLARSAEAFDVHLLECLLAWQMGATVVTMRRSLLLADLGVAMANANVTHACVVPSLFFTQGRRIVPSDLPSLRALIVGGEKIADDIVEHWGSSRGHGNASRVLVLNAYGPTEATIGISCTPVYVDSLASDIGTAFAGNAFVIRANDRVALRGETGELCIVGTHVGLGYIHRDSDAFFEMDGMRAYKTGDLARMMPDGHIEYLGRVGHNQVKVRGARVELTEVDTALQMAGAKHAVTLLLTHPEFEEPHLVAFVSDRIEMCTDSQPPTVTTTDTSYLLHALRHTLVTYMVPSVILTLSALPLARVSGKLDRRALEDIYTTLKRVSLFDHTPPQTLAERTAARVIQDVLGVDEVGVHADLFSLGLDSLKTADHAPVAQYTGAIQNISYGISCRLAYEHGSAGYFASCRYLSRRAVYQCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY43</accession>
    <name>A8PY43_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731404.1">
        <property type="nucleotide sequence ID" value="XM_001731352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY43"/>
    <dbReference type="STRING" id="425265.A8PY43"/>
    <dbReference type="GeneID" id="5855711"/>
    <dbReference type="KEGG" id="mgl:MGL_1587"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1587"/>
    <dbReference type="InParanoid" id="A8PY43"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="52"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="310" mass="34229" checksum="27C1EB73119AE6A7" modified="2008-01-15" version="1">MSFVMLRSLLMQMAQYYARLLQDMTRTPMPNLTGKYEEAGASHLLIWKPRLTLIELQSCAQVLHITVQSLILHAFASLVAEYVGEEEATLGIVLSGRMGDAKHATAHGPCITTVPFRWKATHDAQGVHQQLTEALHHQFVHLTDVAHAIGMDTTLFDVLFSFLPASDATATSLPHGVRAWESYMATDFVYALQVTTNERSNSIVFESTYAPDRVPAEQAGLILRQLEDRLRTIVNGVGIGKDRALDNGCHASDRACLLACVHPEPYEPTEADAFLARFAKHVKTQPDAEGPNVCFKCPTTCRQDIDVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY75</accession>
    <name>A8PY75_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731423.1">
        <property type="nucleotide sequence ID" value="XM_001731371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY75"/>
    <dbReference type="STRING" id="425265.A8PY75"/>
    <dbReference type="GeneID" id="5855730"/>
    <dbReference type="KEGG" id="mgl:MGL_1606"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1606"/>
    <dbReference type="InParanoid" id="A8PY75"/>
    <dbReference type="OMA" id="MPNTWQT"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="4">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="106"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="81870" checksum="6CCC89177F6606A4" modified="2008-01-15" version="1">MAAAESEPLQGRVVWTPPEGKKRMDAFRERICREHDVQLSTYEDLHKWSVSEVGKFWRAVWDEINVIASADAAQVIMDQAPMFPPAEWFVGARLNFAENILHHGQDDDVAVIACTERAQDTCRTTYAELRKQVTQAARALRKLGIVPGDTVASYSGNTLENLVAFLACSAVGAVWTSVAPDFGTSGVLERLTTVRPRVLFSTNQVLYNGKLHDHLGKLNATIDGLLAIQEKEQKDMQAHEAKKASDGQDTQEATDEPQAKKRARLEVAATASRLEHVIIAPYMGTHPESDARPNGVEGMSDAQGLKRHLWSDFLNDGASDEKFEFEQLDFNHPLWILFSSGTTGSPKAITHRAGGMLLQFGKEHLLHGGLKREDVFFQHSSTGWMMWNWLVGALLSGCPVVLYDGSPVHPTEVLWELAAREGVTVFGTSAAYLSIMERRGFVPTELYDRIKVRMILSTGSPLRAELYPYAEKLVGHPVQVGSITGGTDICSLFGTHNEALPVRAGELQCLGLGMDVDVFDDSGHSAPDMVEGDLVCKKPFPVQPIGFWHQPNERYKDSYYTQFPGVWYHGDLVMRSKHGGLIMLGRSDGVLNPSGIRFGSADIYEVLESSEATVATSPLSKISDSLVVALKTPAKDDEVVVLFLVVPEDTSDAEWESIAAGSKSLIRKQRSARHVPTFVRRVKGCPKTLNGKRVEVPVKKLINGAPISTINKSTLMNPEVLDEYIAMGEELRKTLAESRAPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYB8</accession>
    <name>A8PYB8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731448.1">
        <property type="nucleotide sequence ID" value="XM_001731396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYB8"/>
    <dbReference type="FunCoup" id="A8PYB8">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYB8"/>
    <dbReference type="GeneID" id="5855755"/>
    <dbReference type="KEGG" id="mgl:MGL_1631"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1631"/>
    <dbReference type="InParanoid" id="A8PYB8"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054608">
        <property type="entry name" value="SYY-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22421">
        <property type="entry name" value="SYY_C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tyrosine--tRNA ligase SYY-like C-terminal" evidence="12">
        <location>
            <begin position="423"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="499" mass="55380" checksum="38812C2ED8E4C66F" modified="2008-01-15" version="1">MQACRRPITTFRSVVDVLESRGMVQATTSRALKEHLAMPGEASSTPHQHIKRTIYSGVDPSAPSLHVGNLLPLVALLHCAIYGHKALVLIGGATGAIGDPSGRSSERSALGTDQLTSNVTTIRAQIFQFFHNAAAYLSRRNILHAEPVLFGSCNQQSWENECLFQTALDIQLVNNLDWFRDIKMLDFLSSVGRYVRVNDMMARDSVKSRLFPSEGGPATTGLSFTEFSYQLMQAYDYCYLHERMGCSVQLGGSDQMGNIMAGIDLIRRQRAAHVQNDKMSDLSMRADPAYGLTLPLLMTSSGVKFGKSAGNAVWISPALLSDLDFYQYFVRSADADVERYLTSLTFMPLEEIKQVMILHSQDRSKRVAQICLANEMTELVRGPDALRRAQLATKVLFDTDVNALTLEQILYAFEGDPRLVRLTETQTMDLLRLAAEIGLVSSRSEARRLVQQGSSGLYVNNVPVKDVQAKLEPEHLLNGQFFVMRAGKSNHKIVVLEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYF2</accession>
    <name>A8PYF2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13 14">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 13 14">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_1650</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 13 14"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731467.1">
        <property type="nucleotide sequence ID" value="XM_001731415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYF2"/>
    <dbReference type="FunCoup" id="A8PYF2">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYF2"/>
    <dbReference type="GeneID" id="5855774"/>
    <dbReference type="KEGG" id="mgl:MGL_1650"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1650"/>
    <dbReference type="InParanoid" id="A8PYF2"/>
    <dbReference type="OMA" id="LTLHAMM"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="10"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="204"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP44253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="430" mass="46384" checksum="15D8944319A8BB74" modified="2008-01-15" version="1">MSVYQATCTAPVNIAVIKYWGKRDTKLVLPTNDSLSVTLDQDHLRTVTTARADASFGTDEAGTRQDKLWLNGAEESIKPGGRLDACLCEMRKLRAELEAKDRSLPPLSKWGLRLCSENNFPTAAGLASSASGFAALAVSVAELYGLRAVMTSSQLSIIARRGSGSACRSVLGGFVAWQMGTADDGSDSFAIPIAEREHWPDLHVLICVVNDAKKGTSSTVGMQNTVETSPLLQHRIKHVVPERMQQMNEAIQKRDFAAFTQLTTADSNNFHACCLDTTPPIFYMNDTSRAIVHVVEELNRARAEAGEDPIAAYTFDAGPNAVLYVREKDMSCVRQVVQHYFPGATMDDRLQGAANDASEAPASSLSSSSLSLPLPSSLPATFRPDVVPVHPAGSVRRLIHTRVGDGPRVLEHGQGPESLLSADGMPVHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYS2</accession>
    <name>A8PYS2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MGL_1714</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731531.1">
        <property type="nucleotide sequence ID" value="XM_001731479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYS2"/>
    <dbReference type="FunCoup" id="A8PYS2">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYS2"/>
    <dbReference type="GeneID" id="5855838"/>
    <dbReference type="KEGG" id="mgl:MGL_1714"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1714"/>
    <dbReference type="InParanoid" id="A8PYS2"/>
    <dbReference type="OMA" id="YQEIKMH"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="111"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="368"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EDP44317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="463" mass="52891" checksum="67E64C760588ABD3" modified="2008-01-15" version="1">MTQERSECTEDEARKSNVDVQELKTESLPKEKVDGSSTCGIYVQSDTQAPPPCRQAKRRRTSDSAMNENVSETEHREEKERANAPESVADEFNVPPKREKPAVIEERTGLIQFRVVTNDNKPESLVILTGLKHIFMKQLPKMPREYITRLVLDRNHWSMAIVKRGLQVVGGITYRPFPHREFAEIVFCAISSSEQVKGYGSHLMNHLKDHVKDVSPIKHFLTYADNYAIGYFKKQGFSKDISLPRSVWVGYIKDYEGGTLMQCTMVPRVRYLEIHDFLATQKRMIQARISSFSRSHIVYPGLDVFKQGKKDEKRDITSQASKVEMIVQPNEVPGLRESGWTPEMDELSSRSKRGPHFAVMRHILVELNGHASAWPFVVPVNANDVPDYYTVITNPMDLSTMESKLENNQYETVDDLVKDAQLVFDNCKLYNPASSPYAKCAVKLEKFLYERLPQWKQAAGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZA2</accession>
    <name>A8PZA2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730903.1">
        <property type="nucleotide sequence ID" value="XM_001730851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZA2"/>
    <dbReference type="FunCoup" id="A8PZA2">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZA2"/>
    <dbReference type="GeneID" id="5855210"/>
    <dbReference type="KEGG" id="mgl:MGL_1902"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1902"/>
    <dbReference type="InParanoid" id="A8PZA2"/>
    <dbReference type="OMA" id="WQGSVEK"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="168"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36985" checksum="0D90E4488D84D13A" modified="2008-01-15" version="1">MVLLPSKTYDDVPERPFPASKPRPPTWPLIEHEHSPIDHLVQHPIPIPPPTVNIKVQPHGVILTKQEMKKMRRQRRAAEQQDKRDRIKMGLLPPDPPKIKLANLMRVLGNEAIADPTKVEARVRREVAARHEMHERANAERMLTDEERRDRRIYKTKVEEAKGIWCQVYRIENLSSPSHRFKVRKNAQQHHLSGLVLTHPDFSLVVVEGAAKALKAYKRLMLVRIDWTDPGRPRQSSVDDDDVDDENQNGPSRAIASKQQGDESMDLSSNTCELVFEGPVRDRSFPAGSVRMESCPTDMNAKDALGPKLAGYWDVAKRSVAARDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZD0</accession>
    <name>A8PZD0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1909</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730910.1">
        <property type="nucleotide sequence ID" value="XM_001730858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZD0"/>
    <dbReference type="STRING" id="425265.A8PZD0"/>
    <dbReference type="GeneID" id="5855217"/>
    <dbReference type="KEGG" id="mgl:MGL_1909"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1909"/>
    <dbReference type="InParanoid" id="A8PZD0"/>
    <dbReference type="OMA" id="PIMCLES"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="13">
        <location>
            <begin position="272"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="503" mass="56338" checksum="10C267F3295D86C7" modified="2008-01-15" version="1">MDFFGQRGKPSRPGQRPASIVTTTTTTARVQTSQIPTTHKKPPLARHNALPDAVKKRIERDRIAAHKATGNDANNTHTVRDSNSMQATYEQPKKRAKTSSAPRERTNRFRRSPIKEDDDHSDDASGSNLEHITHKTRPIPSRSKFEYHVPREILDVPGYNPLSEEVRVNKAPTISSRALVEASGAEYELCTCSILDIANDLFWGCTDFENLDRDTVVILEYPASEAVEEFTLLVPKEVDEYDPISDLLSAVGVMVAHYVPSDMQAEFGSLESLETSSNAGMPLKKTVGASLPMKNAGEFDHASPPPLDDEPILRAFSKARNRRNGPLFVRTLDRFNAKMRQLKKDGILAAHVQWLGQTHGVPQHVWRIIQEQVYARVVAPHVGKLKQYEAFSDHVYGEMLPPFLSEIARVANMGPSSVFVDLGSGIGNLLVQASLQTGCEAYGCEYMQVPSELATRQIMEATHRWRMWLLCGGRRLEAWHEDFTDSEHVRNVLRRADVVLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q013</accession>
    <name>A8Q013_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730971.1">
        <property type="nucleotide sequence ID" value="XM_001730919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q013"/>
    <dbReference type="FunCoup" id="A8Q013">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q013"/>
    <dbReference type="GeneID" id="5855278"/>
    <dbReference type="KEGG" id="mgl:MGL_1970"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1970"/>
    <dbReference type="InParanoid" id="A8Q013"/>
    <dbReference type="OMA" id="PRDFKLC"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="41"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="468" mass="52533" checksum="4D278617CFB5F460" modified="2008-01-15" version="1">MSTRTSKPTRFLTQPSKRLYDELHRGTDVWTFFNPSVFPEAVNLGQGFMNWRPPTFVLEQLQKEMVERTDVHHYSPARGRPRLLKAISDTFSQSFHKPDAVGEAKMKEGIVDLDAQGLPKQRPASDARLDPTSEIVVTAGANEAMYCATTAFLEEGDEVVIMEPVFDQYVCETTFNGGTPIYVPILPPQSGRHAHDTQEKPLAVSANEWTFDWVALEEKLASPKAKMLFLNTPHNPIGKVCTLEELQRLAQLCIKHDILVIADEVYDCLTYEGHKHIRIASISGMWERTITVGSAGKSFACTGWRVGWAVGPAHLMTPLLAAHVRLTFCVNSLASEGTAIALEGARTNGFFERQRQEYEARRQELINMLEDVGLPYTIPYGSYFVLVDATNIQIPDDFAMPEQVRAKPRDYQVCWFIGKVCDVVAIPATAFYSSDGSALGERFIRFAFCKDGQIREAAQPLQRLRSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0M3</accession>
    <name>A8Q0M3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731055.1">
        <property type="nucleotide sequence ID" value="XM_001731003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0M3"/>
    <dbReference type="FunCoup" id="A8Q0M3">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0M3"/>
    <dbReference type="GeneID" id="5855362"/>
    <dbReference type="KEGG" id="mgl:MGL_2054"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2054"/>
    <dbReference type="InParanoid" id="A8Q0M3"/>
    <dbReference type="OMA" id="DAHDMRK"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="167" mass="19478" checksum="EA4CF9298F4BC1ED" modified="2008-01-15" version="1">MTTVRPFCARDLFAFNNVNMDHWTETYSNGFYLSYLAQWPDMTLTACAAHTGNLMGYVLGKAEGKEPRTDPKRRKQQEPTLHGHITAVTVAPEYRRLGVAHMLMDFFEYCSEHVYRGYFVDLFVRPSNKKAVDMYEKRGYSVYRRVHAYYQGMPPNEPEDGYGTYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0X9</accession>
    <name>A8Q0X9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2097</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731098.1">
        <property type="nucleotide sequence ID" value="XM_001731046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0X9"/>
    <dbReference type="FunCoup" id="A8Q0X9">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0X9"/>
    <dbReference type="GeneID" id="5855405"/>
    <dbReference type="KEGG" id="mgl:MGL_2097"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2097"/>
    <dbReference type="InParanoid" id="A8Q0X9"/>
    <dbReference type="OMA" id="RGGCPFV"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000388">
        <property type="entry name" value="Putative RING zinc finger domain superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="362"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="410" mass="46782" checksum="3D5E8EDE61D9DFB6" modified="2008-01-15" version="1">MFAYTSFTSDDWMTSALGSHELPDDMQRKAAWPGNKILVPSADVSYRTKPAGFGPDRVDEDGLWGTLIPIQIYLDSSENTGCVEEWTSGTLREEGYIKDSLLQTVMQKRTKKQPPSDWIALVERGQCTFEQKVRTAQLMGAKAVVVGDFQSRGYENEPLTLREPEDVTEQDAHMPLIMAPDGDASDIEIPSCFVVRTTYMELMNFVRQTDSQLRVGLYLDASLEDSPLQDIGLFIFILPALFALSAVLLQHVRLWIKRFRERASVYVVRSLPCYTWRPGGAWERLSPDDIPEKHTQDKVLWFMQKVDATWESMKNAFSRRDPEQEALVRESEQLHHDSTTLDQRPGRTAVTQSGRLFMQDECPICLAEFDDGDRVRVLPCGHVFHQDEIDDWLTAARRLCPTCKQDISHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q178</accession>
    <name>A8Q178_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730748.1">
        <property type="nucleotide sequence ID" value="XM_001730696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q178"/>
    <dbReference type="STRING" id="425265.A8Q178"/>
    <dbReference type="GeneID" id="5855055"/>
    <dbReference type="KEGG" id="mgl:MGL_1747"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1747"/>
    <dbReference type="InParanoid" id="A8Q178"/>
    <dbReference type="OMA" id="ARQYYFP"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725408" evidence="1">
        <location>
            <begin position="21"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="270" mass="29593" checksum="FA633034534505EF" modified="2008-01-15" version="1">MISAAQCFALLAVFFSVALASVPAIERNEIQHVAKAEPWRVTTPESDRVDKHVQLCSDENRGTQWRRGWADPAEHGGSMLDLVGNGFREPINVIISGASDQSLMSDQGLLDYSRSIGFSFECLHLHAGGLQHANLGDGQGYVPQLYEYRSIFSPRSPGAWIGACWESLAGGNHFRAWRQNGSLANTGAWFLAVSKEEDVTKSHTISTNGYDVGRDLLVHAATKGGRFLGQSWKATVEWKEGLLRPGKQGINHNISIDGRVAILTVHKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1I3</accession>
    <name>A8Q1I3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730793.1">
        <property type="nucleotide sequence ID" value="XM_001730741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1I3"/>
    <dbReference type="FunCoup" id="A8Q1I3">
        <property type="interactions" value="733"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1I3"/>
    <dbReference type="GeneID" id="5855100"/>
    <dbReference type="KEGG" id="mgl:MGL_1792"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1792"/>
    <dbReference type="InParanoid" id="A8Q1I3"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20529" checksum="F55F984EBBEA6121" modified="2008-01-15" version="1">MAEMRSAIKALSEHVPSNEFYKWIDVWSGCMKGSVFVVLLVFYVVTGRLLSKEAVAHVLGIDNLPANRMCLTTDEYLHGMISLVNELPRLSMYLVIKGNYNAPERIASNVNQIHSTFKELNLKNDSLRKRFDSIKYDVKRLEEILYDLTLRGLLGTSGSDCPDLVPVTDAAFSEQFYTRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q288</accession>
    <name>A8Q288_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730714.1">
        <property type="nucleotide sequence ID" value="XM_001730662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q288"/>
    <dbReference type="STRING" id="425265.A8Q288"/>
    <dbReference type="GeneID" id="5855020"/>
    <dbReference type="KEGG" id="mgl:MGL_2168"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2168"/>
    <dbReference type="InParanoid" id="A8Q288"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727167" evidence="2">
        <location>
            <begin position="18"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="408" mass="45578" checksum="29DBA686E74C32D4" modified="2008-01-15" version="1">MLSAMLVMCLDDSLTAAYRPAPPTYNLPSKLEDFASLDWGMQPSNTDSERDSDTISDQSDPSTPATSVRDDALELPWFEQTMPPLLLVIQALTSLHERDDAPVQLALARSAHLLLLRMHETLEWARQDTEMDPCEALTCCLLDLAHPSNAKTVVECARHAVQDTGSIVLSVLDRVLDIALSSLSGSITRVHDTFVRMHADRVAVCVSVLSRELRDVQFQSINSAFLRLASSDAQFERWIDPLARALSMSSDALELIADDSVPHVSLVLADLEPSTMDALALMWSEWGQATAIFLQYAVQKGSTVRYQDVFALPLYMMESARLCRLTDIARARALLFAMNEMMLGMSGLFSARDTEVWMALPQGRAIRKAVHAFARRVVQSIQHAWQAELEEPNDFEQRSEQAQQYYVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2V6</accession>
    <name>A8Q2V6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2246</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730450.1">
        <property type="nucleotide sequence ID" value="XM_001730398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2V6"/>
    <dbReference type="STRING" id="425265.A8Q2V6"/>
    <dbReference type="GeneID" id="5854757"/>
    <dbReference type="KEGG" id="mgl:MGL_2246"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2246"/>
    <dbReference type="InParanoid" id="A8Q2V6"/>
    <dbReference type="OMA" id="TQSHELP"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="235"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="502" mass="55458" checksum="01F23677069141D5" modified="2008-01-15" version="1">MGARHTKRRTRTHGPTVRQSDVPWVALPISSASEQVNETTDDGFEGLDVFGDDFLGLQAAEGFDVVHEADESGKNHRVKIVKADPAPKAKAKRREIQKQGNHKNEHQEANERTSSQQDRGANEAATEAKSRAKTPSIPTTQSHELPSTKDRKRKASAALDVHDADRDIGTLLQTAREQGMLHEDDAGDDGQEAADAAAPGWASYALHPQLKMALKSLGFHKPTDVQAATLRPSLGLESSMPRDVVGIAQTGSGKTLAYALPILHYVLEHSAHTEDTQRDLEALILTPTRELALQVCTHIRAVVDAAGRFANVATVCGGMSVQKQERMLQQHGGAHVIVATPGRLWDLLKQDDALALRVRRTRFLVIDEADRMIETGHFAEMDSILSMVRRTKGAVADANSAMQTFVYSATMTKTLQANLKRAPWRKKQRTAASSNNNTLDDLLARIDFRDPEPVVIELTPQRHVADTLYEAKIECVGQDKDTYLYYLLLRYQGRTLVFFECN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2X0</accession>
    <name>A8Q2X0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2260</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730464.1">
        <property type="nucleotide sequence ID" value="XM_001730412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2X0"/>
    <dbReference type="FunCoup" id="A8Q2X0">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2X0"/>
    <dbReference type="GeneID" id="5854771"/>
    <dbReference type="KEGG" id="mgl:MGL_2260"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2260"/>
    <dbReference type="InParanoid" id="A8Q2X0"/>
    <dbReference type="OMA" id="WSYILWQ"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="209" mass="23778" checksum="82BB09188E044917" modified="2008-01-15" version="1">MSPIVAELLSRASTLHDHIAPLVVVTQSLAVFEFIHAALGLVKSNPFITAIQVLSRLIVVWLVSEKYESAAHSPYYATLILAWSLSEVGRYPFYVNQLLNSPSFMALWARYSFFVILYPLGVFSELQLIFASLPHNAPWPWVDMSAWSLRDLFFLAVIPLYGPGLIMLYSRLLASRRKVLGNDFIGSKGREEMRKIHEAKLRSPRQRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2Z3</accession>
    <name>A8Q2Z3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NF-X1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730479.1">
        <property type="nucleotide sequence ID" value="XM_001730427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2Z3"/>
    <dbReference type="STRING" id="425265.A8Q2Z3"/>
    <dbReference type="GeneID" id="5854786"/>
    <dbReference type="KEGG" id="mgl:MGL_2275"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2275"/>
    <dbReference type="InParanoid" id="A8Q2Z3"/>
    <dbReference type="OrthoDB" id="3345748at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="10">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="428" mass="45823" checksum="CEF20761302F20A2" modified="2008-01-15" version="1">MSAVPCSRRNVRCGEPCRALLACGQHICPGACHAEGECPPCNQVCGRPRPVCGHPCERPCHAPEPCSADEPCKAVLARRCACGHREKLDVCGAAPGIERPPVPPLECVPACKVAQRNARFARALGLDTQREEVSYSATLLQYVAQNPRGSQAVQEVLNEFVQSPRVSAQLRALLTSFAVRRGCEPIKVDAPLLAFTEELAHAYHLEVGLCTPQGLIHTGPVPSNGRDVDVRLRRLRDTRIPTVLLTEFAASHPARTSLEARRLRSAATAARGSATAMGSPTSGASVPRGNALWITAPRSVTGEAALENMDQTALATALGDASLGGRRSWKMVCCNEGTLLTHIQLEPQSLAAIASRPKPPGSDALSPIERRLLWVSEDVQRALASAGAPTDEEVLLCSCTEGGQVTHVFRDGRWSRQDVVMNKTASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2Z6</accession>
    <name>A8Q2Z6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2277</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730481.1">
        <property type="nucleotide sequence ID" value="XM_001730429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2Z6"/>
    <dbReference type="STRING" id="425265.A8Q2Z6"/>
    <dbReference type="GeneID" id="5854788"/>
    <dbReference type="KEGG" id="mgl:MGL_2277"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2277"/>
    <dbReference type="InParanoid" id="A8Q2Z6"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="197" mass="21176" checksum="0046F9012360F7B0" modified="2008-01-15" version="1">MVSESFVHACAGGAGGLVAMTATYPLMGISTRAAVDRSKHPGESLFKAITTVIAKEGVRGLYDGLGSSLIGIGVTNFVYYFFFEAARDFILTSKRFTRSAKAKLGALTTVQSILAGLVAGVATALISNPIWVINTRQTVRVTQSDNETDRTKKAVKRKTFIPYSQTHCREGWRPCSLEGHRSSSRPCDKSCAAVHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3N0</accession>
    <name>A8Q3N0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730657.1">
        <property type="nucleotide sequence ID" value="XM_001730605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3N0"/>
    <dbReference type="GeneID" id="5854964"/>
    <dbReference type="KEGG" id="mgl:MGL_2453"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2453"/>
    <dbReference type="InParanoid" id="A8Q3N0"/>
    <dbReference type="OrthoDB" id="266518at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389:SF0">
        <property type="entry name" value="ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389">
        <property type="entry name" value="P53 INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="264" mass="28905" checksum="F2B728C0613E5BD7" modified="2008-01-15" version="1">MSRRNRSALQSVDFDTDESVSVQLDENYDDGLALTGSGVWSSKGPSEAGPRVSVQKTAVLHTKWAWRGLVDASSIGGAVLLMKSYLIASTWSVGIAEAAFMAQGIKPHPKGGSETAWIEYAVRTVLILNYSLICFALQNLPVVGRILSFLVMSFVDGFFCFEQIWSVRGWPLEKRLRFAESHWSFLMGFGIPSTMISFFHPSGLLNLMLFMLVFPIYCDASLYDARSNTRAASVPVLTSANSFVLANGPRPPLAFVAHTTCCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q482</accession>
    <name>A8Q482_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730127.1">
        <property type="nucleotide sequence ID" value="XM_001730075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q482"/>
    <dbReference type="FunCoup" id="A8Q482">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q482"/>
    <dbReference type="GeneID" id="5854434"/>
    <dbReference type="KEGG" id="mgl:MGL_2509"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2509"/>
    <dbReference type="InParanoid" id="A8Q482"/>
    <dbReference type="OMA" id="WTAYILI"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="181" mass="20424" checksum="D4BE8B08E6B95FD8" modified="2008-01-15" version="1">MVKHVRETPDEVVDQAVAPNVNAEWVNMKGAWVIHVVLIVLAKLIINEVPGISDAMKWTIVNMGYMLVSYCIFHYVKGAPLDLNSGAYDELTLWEQIDQGYQYTPAKKYLTSLPIAMFLLSTHYSHYNPWLFSLNLAGLLLVLFPKLPILHRLRFLFFPSSSTAPSGVNTPLRRPSGFMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q494</accession>
    <name>A8Q494_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730131.1">
        <property type="nucleotide sequence ID" value="XM_001730079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q494"/>
    <dbReference type="STRING" id="425265.A8Q494"/>
    <dbReference type="GeneID" id="5854438"/>
    <dbReference type="KEGG" id="mgl:MGL_2513"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2513"/>
    <dbReference type="InParanoid" id="A8Q494"/>
    <dbReference type="OMA" id="WDEGFAG"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="91" mass="10006" checksum="565159A0B96B91C5" modified="2008-01-15" version="1">MAKPGNRVSMRYVGKLQNGSVFDSNTKGRPFSFRLGKGEVIKGWDEGVKGMQVGSERRLTCPPHLAYGKTKLPGIPANSTLIFDVKLLEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4E6</accession>
    <name>A8Q4E6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730149.1">
        <property type="nucleotide sequence ID" value="XM_001730097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4E6"/>
    <dbReference type="FunCoup" id="A8Q4E6">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4E6"/>
    <dbReference type="ESTHER" id="malgo-a8q4e6">
        <property type="family name" value="Acidic_Lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="5854456"/>
    <dbReference type="KEGG" id="mgl:MGL_2531"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2531"/>
    <dbReference type="InParanoid" id="A8Q4E6"/>
    <dbReference type="OMA" id="DPRFWAW"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="5">
        <location>
            <begin position="325"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="679" mass="78138" checksum="0E00746720BB4B33" modified="2008-01-15" version="1">MSRVSSQRRRSSRHAHKGKKYSSLDSKNYRNAPPSLLDEQMEGTHNDWDDGESESRALRAGSEMNEPNEFEDAYEDTATGSLALDDPYYYDPYNEDETFGESDTYRSTDPYPDRDAHDNLYDAPSTYLESSRTGVDDDDYETRDHDDDPELLSGDEDHEWSTPGGRSAGGFGALHSPPTHPAHAYKGKMGEYYPVESDHAQSRGHGVYVEKPHTAFEDVAEDELPEDKGVPFHSQEPSPAEADPEQFPTFFHHEIGQYGEFNLVSRLMLELQQLNMFLITSLGMTFVVILAFARYFNPFRKLYPKARVDFEYERRITGERYSERVQYYADFWGYQCEEYEIVTQGGWILKAHRISDPRRPGGRGYPVVLQHGILCTSLFFFTSEERSLGFWLVDQGYDVWSTNIRSNFRSGHTRFKRWDPRFWAWSLIELGDDLVDVVDFVLQETGYKQLAYVGHSQGTGSMFLALNKYKGFGQKISSFTALGPAVYPGSSLDRLPFRVMRMLPSRWTWSIVFGVRTFMPLLELARIILPKFLMGHLGYIVFGYLFDFHDHNWVDRHKPKIFCSTGVSTSSELLYYWIHCFVARGCVFDPRVRSPWFSAEFPPLTVAYGTIDHLVAGKPLVDRLLQYESNVQIVHILELQGYEHMDMVLGCDAYKVVFPKIKDTIVRTIDPEDVPMLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4S6</accession>
    <name>A8Q4S6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2626</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730244.1">
        <property type="nucleotide sequence ID" value="XM_001730192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4S6"/>
    <dbReference type="FunCoup" id="A8Q4S6">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4S6"/>
    <dbReference type="GeneID" id="5854549"/>
    <dbReference type="KEGG" id="mgl:MGL_2626"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2626"/>
    <dbReference type="InParanoid" id="A8Q4S6"/>
    <dbReference type="OMA" id="VILVRKH"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="245"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="309"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="561" mass="64433" checksum="B8ED117C5AD4CB3F" modified="2008-01-15" version="1">MEYHASAPQRMVLCADCGIPIEPNNANRCVNCLRNSIDITESIPRQATINFCRNCERYLNPPNTWVIAQLESRELLAICLKKLRGLKSVRLVDANFVWTEPHSKRLRVKLTVQKEVYTSTILERCFEVEILVQYGQCPDCTRLAAKNMWKAAVQVRQKVAHKRTFLYLEQLILKYNAHRETVSVQEKKDGLDFFYVQRAHAIRMCEFLASVVPVRMNKSEQLISMDVHTSQSNYKFTYSVEIVPLCKDDLICLPLHVARSLGNIGQFVLPYRISNVIKLIDPVTLQMADLTAEKYWRDPFPALCSIPEMVEFLVLDIETTGTIAHGPHGQSMSKFMAADAQVSPLHASTFGESDAVYHVRTHLGHILNPGDTVMGYYLATANFNSDEWDAIPEERRPDVVLVKKSYPERKRRSKRNWKLKSIAKEAEDPSAGEHVVGRGALGRRGGLDSQRVERDYEQFLRDLEEDEEMRANVNMYKDKERIARDEERRRRRETRYRDPQAMEDDEDDQQPPRDSSSAMDSMDDGGATTDNDSEYGSDSELPRVQLDELLDDMDEMAIEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4V2</accession>
    <name>A8Q4V2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730265.1">
        <property type="nucleotide sequence ID" value="XM_001730213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4V2"/>
    <dbReference type="FunCoup" id="A8Q4V2">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4V2"/>
    <dbReference type="GeneID" id="5854570"/>
    <dbReference type="KEGG" id="mgl:MGL_2647"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2647"/>
    <dbReference type="InParanoid" id="A8Q4V2"/>
    <dbReference type="OMA" id="WRPMRGM"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="35"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="131"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="222"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="319" mass="34745" checksum="6B9CF79BD7E1C7B7" modified="2008-01-15" version="1">MNKEHDTAQIYIAPDMPIQEAMEPEIDYEGLGGNYPIHINMLAGSLAGITEHSVMFPVDLVRTRMQVLTTSPSTSYTGILNAFSRISSAEGFRALWKGVASVVLGAGPAHALYFGTYEFMKDVMGGNEAGFQFLSTSVAGASATIVSDAFMNPFDVIKQRMQLFGSSYRSVAHCARSLYRAEGLRAFYLSYPTTLTMTVPFTAIQFVAYEWAQSLMNPSSTYSPLSHAVSGGFAGAMAAACTTPLDVAKTMLQTSGSSSDPEIRRVTTMGSAFKTIYAREGLRGFARGLSPRIFTHMPSNALCWLSYEGFRFAIQEYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q559</accession>
    <name>A8Q559_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730348.1">
        <property type="nucleotide sequence ID" value="XM_001730296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q559"/>
    <dbReference type="STRING" id="425265.A8Q559"/>
    <dbReference type="GeneID" id="5854653"/>
    <dbReference type="KEGG" id="mgl:MGL_2730"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2730"/>
    <dbReference type="InParanoid" id="A8Q559"/>
    <dbReference type="OMA" id="MTWECLA"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="69108" checksum="26FD5A6F52AAA41F" modified="2008-01-15" version="1">MSHELAKDIVTTLRTSWKFAAICQFLMTFNDALQLQDFQTHRLETAFAQDDMSYISWLFTQLLRFVSQNRYITQEHWEDAFRQYWHTYRQPSERAPLGTQDIPVSWNALDTYEKLTCLHELCEWQLAWPERLRRMNDSDDDAVTWRVLPAGWDREGNTYWLFDDNRLWVQRAPPKRPKRNQSLSCQASSTSKAKRRKTSSRPPPRPAGRRSSRLNPHSGADQSDVSASEAPTRNREEGLFNSDSDLSPPTDPEKPWTEFETICVTRSEWENFAGRFEHSKHPDERNLHVYISKEVLPPILDMIHAEEKKAALEAALSKRKRSSRIALRDSEREQREREEAELRALKERAAAALKAERDHQAREEAELQARKSREDRLRERGERLLARERMINERQKRAEERSRDPWHLRCDICLMDELNPIDSRPVVACEKCGVWQHMSCWDEHDRSHRRLPRRWDNVSFCCQHCKASPMLSAHAVPAALDQTDETGAHTLPSEPQVPTTPPISQTSVLHGSRVSSQASPSNASLVRPASPARVPHLSPRGSFPLRTHLTKSPLSRAVEPEDVPTPLSLHRGDPNLLLQGHPVSPVSKDQEPAPQTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5H7</accession>
    <name>A8Q5H7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729793.1">
        <property type="nucleotide sequence ID" value="XM_001729741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5H7"/>
    <dbReference type="FunCoup" id="A8Q5H7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="5854113"/>
    <dbReference type="KEGG" id="mgl:MGL_2779"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2779"/>
    <dbReference type="InParanoid" id="A8Q5H7"/>
    <dbReference type="OMA" id="PNSSADY"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="47105" checksum="7EC59F49A4447CEA" modified="2008-01-15" version="1">MSLPYSWKDVQRRIMDRGVWANVHARMSARSRVTNLGVILLACAFFVSLLFNTRSRKIYVTAPTSEQSNCDPIPYNIHMRDAVPKYPGADKSPLTHLVIVAGHAIWNGNDPNTVLNDSTWFLEDYQRGGSVKTFLKHIETGIQIAAQDSSSLLVFSGGQTREQSWTTEAETYMHLALALSKDLPYFADSDTEFPESQPPFEPLDTGMKYTRDVLSSSSIAMHRFLNLAQLRMTTENYALDSFQNLLFSIARFYEFTGTYPQRITVVSYEFKKDRFTDLHAHAIRWPTNKYLPGGSRRFTYVGIDDEGSSSAKLHDTAYDLFELDMYGCYGRLLDKRRKRNWSRRIQPYTSTAPELAGLLDWCPAINSRLQGLYPGWLPWDARASTGLGRGAQAILKQNGGKFIQAEYLPDGKKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5T7</accession>
    <name>A8Q5T7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2815</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729829.1">
        <property type="nucleotide sequence ID" value="XM_001729777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5T7"/>
    <dbReference type="FunCoup" id="A8Q5T7">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5T7"/>
    <dbReference type="GeneID" id="5854136"/>
    <dbReference type="KEGG" id="mgl:MGL_2815"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2815"/>
    <dbReference type="InParanoid" id="A8Q5T7"/>
    <dbReference type="OMA" id="FTYVRRF"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="30"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="479"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="656" mass="72261" checksum="D403AC827436F046" modified="2008-01-15" version="1">MAVSVTLPADESERFSSLALSLVLFLLITSFLTSYYLKVKRITAVHETIVGLFAGMFVGVMLRLGPLQPVREMLSFSNTIMLNVLLPPIILSSGYDLSQAKFFRNFGTIIVFAFFGTFISALVIGVIVWTASFLRLVRPHLSLIECLIFGSTLSATDPVTILAIFNTYKVDPQLYSIIFGESMLNDAVSIVMFETLNQLRGSKLSFLSIFYGFGIFAVVFSFSMVLGVVFGLACSLLLKHTQLGAFPELESCVVMLVAYTSYFFSNTVEMSGIVSLLFCGITLKHYAYHNMSLKTQRTTKSSFQTLSSISENFIFIYLGLSLFTGEHLVYRPTLILFTIVAVVASRYCSVFSIAWVLNQIHGFRAERRRQFSAGLPDNSSHYIPRHYQLMLFWAGLRGAVGFALSEGIRGSNAYPLQTSVLVAVVITVIVFGGTTAQMLEILRIDTGVEDQEDPSSDHDEEALSSDVWVSSNRTLPASGWYRDSSVEPGDMSTTPDANEVLPGPDTDTAPDASTSASRPGAHNSADGASSALTKAFVAGPGGLRSCTSDELDETGDMSATEPPLSARDVLDRANLIFRDGQWFQRIDERYLLPMFSNTVANRKHEQRKEQVQARRHISREFAQAQPSPSVLAVPYEQASHEALEEGRVSPGKNKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5Z0</accession>
    <name>A8Q5Z0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729846.1">
        <property type="nucleotide sequence ID" value="XM_001729794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5Z0"/>
    <dbReference type="STRING" id="425265.A8Q5Z0"/>
    <dbReference type="GeneID" id="5854153"/>
    <dbReference type="KEGG" id="mgl:MGL_2832"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2832"/>
    <dbReference type="InParanoid" id="A8Q5Z0"/>
    <dbReference type="OMA" id="SWRQWAD"/>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="743"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="814" mass="88774" checksum="4598ACACF8BC42A9" modified="2008-01-15" version="1">MLNEGRDEFEQRGQTDQPQQEQEPTEQQNTSPLSSDAETEPLTNDDPSLDGTLTQQEAMHVRASPAPAAEGSPTLHGAVVDDVHQADTGETVTPSGNFGSESDLTHESERATPQPTETQDHGAHEDAPPLASSAESWDLTQKPSATGLKCSALDGLAELAASAGDMAQNDTAYTRTNDAGALETHASQDEVVEQEENTYARPVTNDGADADAFDKNVEADDDNNNNDDEDDDGHDDTAPRTPFTQVHDRIDDVAMDMHASPQRKTQSLHRAVIAAMGKRRAAATGGAPSLLVDQDVDSSNPPSAATSRQGSPTADSEDAVDATKAPDQDETASGKEDDNGADEDRSEEALGRMQEETGEEDTENMDVDERLEQRTSRKGQDQTKQEPGEDDSRADTVGEGDSERTEQRRKKATRTNEKEDAVMTTPSKGRGSTSAHSVDAAENEEETSLHRQEALDQLTRIELGFVMLRQRLYTERLEELEREADMIQQGTHPELRILHTLIDTRKEKRLACLDVWLRLQEQEYEHLEKTEEKIAWVNWRDRAASIRREMMSQTDRKRRKLEREKRMLDAPQPARRHQPFEAEFAYKPPAYSRRTRQMPDLYMKSEASLRDVRNFVAYPDVRGLDEYDAWLDMEQMGIRPVPMPPPGYLRVDEVPPAAAHELYVPAPLSSSSYATGGSEAAMPPGAEHMGYYGPLPPPPAGAHRGHFEHGPLPPPAGAYDGMYVDTMDMSRRAPQNAEYEAPIPARPSAAGGAAGVGAPGHASAADSGAGASASTGTGAPPFASSNMPTPTGNYSMSSEQTTLNGVPMTHVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q687</accession>
    <name>A8Q687_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mini-chromosome maintenance complex-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729897.1">
        <property type="nucleotide sequence ID" value="XM_001729845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q687"/>
    <dbReference type="FunCoup" id="A8Q687">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q687"/>
    <dbReference type="GeneID" id="5854204"/>
    <dbReference type="KEGG" id="mgl:MGL_2883"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2883"/>
    <dbReference type="InParanoid" id="A8Q687"/>
    <dbReference type="OMA" id="NCTELAH"/>
    <dbReference type="OrthoDB" id="329666at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="43719" checksum="69B78144D65B2111" modified="2008-01-15" version="1">MNNMRVEQSQHEPKRTPLPEYSNITALVKVYDIDLADKFKTSDVLDMIGLLDVGTLPDANWDLDISEFAAARAPALPCVHTLCVRHAPPLVAGSMSSTALSTTFAPLGTTTSDVRNALIRFLAQALDGDMLMAEYVLLALLGKVHIRRNGIIIGPFSVNLTGLEHVQLRLVETLRQLMPAVVCQPLSVGSLNDPTQPLYVRGTDSGIQAGRLQLAPGTCLILDETKMDEGELNEAGVKNIRALLSLLQYHTLPCVFPYSEMDLPADLVFIILSQGKSILPADVQVHSEAQRNTTQNSAHLSQSSIPSPSTLHAMRVYLAHARQLTFSIPTHVSEQIQNDFVALRRDSRGSFDQNDLQRCLSTARLLSLSHGCTELSADLWQMAKSLDLARASRIEPRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6A3</accession>
    <name>A8Q6A3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2899</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729913.1">
        <property type="nucleotide sequence ID" value="XM_001729861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6A3"/>
    <dbReference type="STRING" id="425265.A8Q6A3"/>
    <dbReference type="GeneID" id="5854220"/>
    <dbReference type="KEGG" id="mgl:MGL_2899"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2899"/>
    <dbReference type="InParanoid" id="A8Q6A3"/>
    <dbReference type="OMA" id="CIRWAPP"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="363" mass="40262" checksum="38BF22D3AA6F99BA" modified="2008-01-15" version="1">MDLTTKVAELEAELQAAPSARRGASLQDWFPRLPARHILLGHRQPITSVAFHPQFSLVATASEDTTIKIWDWETGELEQTLKGHTKPVQGITFDHAGQYLASCSSDLAIKLWDGNDGWKNVRTIHGHDHSVSSIEFMPGDQHILTASRDKSLKLWEVATGFCSRTYVGHDDWVRSVDVSSDGRWFASGSNDQTIRIWDASSSEARHTLRGHEHVVECVAFAPVSAYNAIQTLMAVRLSKSDTDQVQPGQYLASGSRDKTVRIWSQQGQCLRVLAGHDNWVRSLAFSPNGKFLLSVSDDKSMRVWDLATARCLKVFECHAHFATSMAWGRTHVDTSSSSQNSEKQPVNVVATGSVDLSVKIWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6A6</accession>
    <name>A8Q6A6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729916.1">
        <property type="nucleotide sequence ID" value="XM_001729864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6A6"/>
    <dbReference type="FunCoup" id="A8Q6A6">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6A6"/>
    <dbReference type="GeneID" id="5854223"/>
    <dbReference type="KEGG" id="mgl:MGL_2902"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2902"/>
    <dbReference type="InParanoid" id="A8Q6A6"/>
    <dbReference type="OMA" id="RDAKFKK"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="146" mass="16774" checksum="1C668DF119155216" modified="2008-01-15" version="1">MSDEEHEFGNSAPLDDEDLSLPKATIQKLIQEYLPKDLSCAKDTRDLLIDCCVEFIHLVSSEANETCEKESKKTIAPDHVVKALVDLGFEKYTHEVRDVLNDHRQHQKERERKASRFELSGLTEEELQRQQEELFAASKARFDAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6D2</accession>
    <name>A8Q6D2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_2928</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729942.1">
        <property type="nucleotide sequence ID" value="XM_001729890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6D2"/>
    <dbReference type="FunCoup" id="A8Q6D2">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6D2"/>
    <dbReference type="GeneID" id="5854249"/>
    <dbReference type="KEGG" id="mgl:MGL_2928"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2928"/>
    <dbReference type="InParanoid" id="A8Q6D2"/>
    <dbReference type="OMA" id="EGWFPKK"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="256"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="325"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP42728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="363" mass="38602" checksum="64B3D266A094BD2E" modified="2008-01-15" version="1">MGGYGSYGGYGGYGGYGGYGGTYASPYSRLGGYGGYGGMGYGGMGYGGMGYGGMGYGGMGYGGMGYGGMGYGGFGGMGYGQPGENSLTQRMESGTQATFELISSIVATFGGFAQMLESTFMATHSSFFAMVGVADQFAHLRNYLGEVLSIFALARQMKNLYLRMTGRPPVGGIDAKEFGDFRRIGGPGAKAQRSKRPLMIFFLAVIGLPYLMGKLVKLIAAKQDQERNRIAKQAAEAGTDLQTMQDAQGGIGLDPSKLTFVRARFPYNAADGLELSLKQNEIVAVLSKTNPQTGEQSQWWRGRTRDGRIGWFPSTYVETLEQARERAARASQQSRPAIEAAPSSSLTTEAVSKPVVEKSSTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6G9</accession>
    <name>A8Q6G9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vps41 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2963</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729977.1">
        <property type="nucleotide sequence ID" value="XM_001729925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6G9"/>
    <dbReference type="FunCoup" id="A8Q6G9">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6G9"/>
    <dbReference type="GeneID" id="5854284"/>
    <dbReference type="KEGG" id="mgl:MGL_2963"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2963"/>
    <dbReference type="InParanoid" id="A8Q6G9"/>
    <dbReference type="OMA" id="PQLVWQD"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="5">
        <location>
            <begin position="98"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="3">
        <location>
            <begin position="667"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1034" mass="115872" checksum="EC6807EB1D3CEBBA" modified="2008-01-15" version="1">MPGQVPVEGDLHQDDSRIATPRADACGSNTSQTDSPPQTPGASGASPKQVTEMDRQSHELGTDHQKNRCEASGDADDTLSTAVSDSHEPAFHETCLLASVQDIMKKDSASAMAVSRTHIALGTQSGMIYVLSHSGHLEKGFRFHSAPVLDLVFDTSGEFVGSAGMDGIVAIASLTTSEQYQFDHQRPMRTIALEPHFASRSSRAFVCGGMSGVLVYREKRWFGYRDMVIHSDEGPIWTTAWRGHWLAWATDRGVRVANATTHDMITMIPTPQGSPRAELARCSLVWRDSHTLLIAHGDTITVASIKTRESTTADDEIRAVIPGMPTFAGLVTGLNRQAPEPSEYVEITDIFQLDCVVAGMACTPDYMATLAYVSDGTACQAPELRCVNSQGEELSSDVLEVVYEGRYRCNDFHMKMSVEWKYDPVVQQETRRPVFYVASPRQISVLRPRDERDHIEWLLEHDEYRRALEALEALGSAPAKAMGFDVAAIGREYLMYLIDEQDDYAGAAALLPLLLRSDKAAWDSFVLLFLERHQVETILPFIPTQDPELSEVVYDLVLVHLLQENQALLLATLTTWPSHLYSTQAVAAAIHDKARNSRMLLECLAQLYMADRQPGKALPYMIHLRDASVFALIREHNLLIDVQHRIGTLVELDQELAGTSEPRHSVLMPLLVQYTHSIPIERAMQQLQPYPWYEFLYLHALFERDASLVTNYALDLLRLYCRYDYAKLMPFLRSMSSVYSLKEAYAVCEAHNYVPEMVFLRGRSGDLRGALQLILERLRDVEMAIEFVRQQDDSELWESLLAYSDNKPEFIRGLLEHASGEIDPVRMIRPIRHGLIIPGLRSALIKIFTNFHLQHSLFCGGLAVLERDAHERGMQYYASLQTALACDAHTPCAMCHEPLLQLSEYASYKPLVLYLCSHTAHRACVTKTRPDSACLRSSAYAAVPLHATTTDMYNRSRASTWFGSAPTELTVASHATNDDKLKLSGKQAMLERADRDAWIENRQLYRLDVGLHGCPICARAYRERLSDESCVDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q774</accession>
    <name>A8Q774_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="EDP42552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001729714.1"/>
    </dbReference>
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        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q774"/>
    <dbReference type="GeneID" id="5854072"/>
    <dbReference type="KEGG" id="mgl:MGL_3310"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3310"/>
    <dbReference type="InParanoid" id="A8Q774"/>
    <dbReference type="OMA" id="GSWHVDY"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="357" mass="42165" checksum="27FF8031C522F609" modified="2008-01-15" version="1">MNSVREIQRINERELELGLHGSGSWHDQYKDSAYIYVGGLPYDLTEGDVLTIFSQYGEIVNIHLPKPREEPGPSDKDRRAHDPQESKKSHGRNRGFGFLMYEDQRSTVLAVDNLNGSQVLGRTLRVDHVANFKQERVRDAEGNLVEPEEQILNCAPPETVVDEDEDPEHGDGDADLEDPMAAYFAEKRDRERRKKRRRHDDDERSSARRHRERRRKESDLHESRRHRDGRSEERDARYRREEDLERRANDNELPSHHRHGRDYDGAYGDDTDQGSRHHGAHHRERRHRHGGPEGSRHHVHRTEEDSRTWRRRDEQPIHQEHSDYEQRGDVQDRPRHDASRERSVTPIMDRHVRTDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7H0</accession>
    <name>A8Q7H0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729789.1">
        <property type="nucleotide sequence ID" value="XM_001729737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7H0"/>
    <dbReference type="STRING" id="425265.A8Q7H0"/>
    <dbReference type="GeneID" id="5854095"/>
    <dbReference type="KEGG" id="mgl:MGL_3333"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3333"/>
    <dbReference type="InParanoid" id="A8Q7H0"/>
    <dbReference type="OMA" id="WISEPPG"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="264"/>
        </location>
    </feature>
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            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
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        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
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        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
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            <begin position="448"/>
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    </feature>
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        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="713" mass="67933" checksum="5DBF40C028329F2A" modified="2008-01-15" version="1" fragment="single">RSNNGPSNGPDNGPDNGGNNGPNNGPDNGSNNGPSNGPDNGPDNGSNNGPSNGPDNGGNNGPSNGPDNGPDNGGNNGPNNGPDNGGNNGPSNGPDNGPDNGGNNGPNNGPDNGGNNGPSNGPDNGGSNGSNNGPDNGPDNGGNNQPNGPAPSGNPSNPGGGRGDQTNTSGPSPSSPTSPGGERGDVTNTGGPSPSSPTSPGGGRGDQTNTGSPSPSSPTSPGGERGDVTNTGGPSPSSPTSPGGGRGDQTNTGSPSPSSPTSPGGERGDVTNTSGPSPSSPTSPGGGRGDQTNTDVTNTGSPSPSSPTSPGGERGDVTNTGSPSPSSPTSPGGGGGRGDQTNTGGPSPSSPTSPGGERGDVTNTSGPSPSSPTSPGGERGDVTNTSGPSPSSPTSPGGERGDVTNTSGPSPSSPTSPGGERGDVTNTSGPSPSSPTSPGGERGDVTNTSGPSPSSPTSPGGGRGDQTNTGSPSPSSPTESCQSETSMTRVTQTTTNSNGERRTHVTSKTTVVPNRSCTSRTSPRSRPTGERGDTTVTTGPAPSKPTGERGDTTVTTGPAPSKPTGERGDTTVTTGPAPSKPTGERGDTTVTTGPAPSKPTGERGDTTVTTGPAPSKPTGERGDTTVTTGPAPSKPTGERGDTTVTTGPAPSKPTGERGDTTVTTGPAPSKPTGERGDTTVTTGPAPSKPTGERGDTTVTTGPAPSNPTGERVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7X3</accession>
    <name>A8Q7X3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_3149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729605.1">
        <property type="nucleotide sequence ID" value="XM_001729553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7X3"/>
    <dbReference type="FunCoup" id="A8Q7X3">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7X3"/>
    <dbReference type="GeneID" id="5853911"/>
    <dbReference type="KEGG" id="mgl:MGL_3149"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3149"/>
    <dbReference type="InParanoid" id="A8Q7X3"/>
    <dbReference type="OMA" id="PWSLRYG"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP42391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="734" mass="81255" checksum="F67782381940CCAE" modified="2008-01-15" version="1">MPRFRPLSLPTVPLGQQLTANLIPDPVTPDARALVATATSYPSLLRRARVVRDGAHFSFVTPLPLAFPYEFPPPSNDSVSDAESVERYLRDFEPQRTNPGAAFPPARQHSPPFPSARLVAFSPQAHATCLPHLDVGDTHAWLQQTSGVQKVYSSGPSIESQTSTGPVDSAATGAAEPSHLYGQDRSDTATARQALSDWASGRALRVNIQESEPINDEHGTGVHFLARHEDDVQNTKQALAALHTRTSYGPWSLRYGGHQFGQWAGQLGDGRTVSILETLHPETGARHEVQLKGAGRTPYSRFGDGLATLKSSVREFLVSEYMAALGIPTSYSLCVVSLPDLPVLRETSTTAAVNMRIAPSWLRIGNFELHSIRGEWESVRVLGEYVAREMYGWTDVVKGGETWADAEARAGCEGEPRPPWAARLVKEVAKRNAKTFALWQTYGFMHGVLNTDNISLMGDTIDYGPYAFMDAINEDEICNHSDMMGRYSFKMQPTMLVYAIDRLMDALAPVLGFEHVHGRALRPGELLASTKEERQMWADQAEEVLYDDVRMLVQTTLLDAWATAWTTRLGIASQRRIGVDRIKSEIVDPFFKAFYGLDMTRSLRMLCDFPGRTNDIEAFAVSLVQDAAAGVPDCASQADVAAWLHQFKTWLDAEARPASEITNAMKRVNPRFVLRNWITDDVAERLESNAPDTAFLERVRTMCANPFENYAHEEDAELCTVGRLLRTNTPSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7Y7</accession>
    <name>A8Q7Y7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729616.1">
        <property type="nucleotide sequence ID" value="XM_001729564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7Y7"/>
    <dbReference type="STRING" id="425265.A8Q7Y7"/>
    <dbReference type="GeneID" id="5853922"/>
    <dbReference type="KEGG" id="mgl:MGL_3160"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3160"/>
    <dbReference type="InParanoid" id="A8Q7Y7"/>
    <dbReference type="OMA" id="MEANWLA"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="621"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="863" mass="96335" checksum="6872BA9140F394AD" modified="2008-01-15" version="1">MEANWLAGHFQDAQALVSKERKQNDPSVNAKEEHGRVNKREEQKRDESKRGSESEGDSDSDSDSDGDGDGSDGLEAENDEQDDNDVDAEQSNADSSGGSETEDRENEDSDRDAQQSEAGSSDGSEAKDGEHDDNDDDAEQSEVESSDGLEAADDEHDGSDPNPEQSEADNSDGSEAADDELDDSDRDAEQSDADGDALETMESPIDSGDDSEAEENEVVDDVDHDAEESVADGDDPEAEENEIDDHDQHGAEELDFDGNEDHLSEDEFEIDSDDQDVGLGVDEHDDDDDVEYNEALEDDDLINKSALSASDRSMKGSGSLLHSERSSDNNRNEPDSSQSHPHDQRPSPTASSSDSSVIVIDDSDSSPSPGPVSHERTTSRTSSSPPTLSTPPTLVSHPCSSNALSRFLASRAPVAPARPSHFRPQYFHNHAAGALPKTLFRSKRIDAWPKQNRRTVSSLSMRRKAPLAMDDFEARINTRQQARIASMIRQAYQAMRRGGPRLSFDDFHSLVKKRVHVQQLMDLETLQTWPMARPVLDEQAYTQRTLDLLKRREAHAQAQLPPPVAPLEARRTAVRQAREKRRSLHGILGRPPLPASLPPDSDRRVSTAFQQRGVIASMPGAQVEAHDMAKLRPGKWLNDEVINFYGQLIQQRSNDADAENARAKHGPCAFWRVHVFSSFFWQNLTTRGYAGVRRWSRRVDLFTKDLVLMPINVGQAHWVCAAINLRLRRFEYYDSMGMPSPVVFERLRAYLQDEMRDKKHMELDLSDWTDFFADYTSPQQRNGYDCGVFAVQTLEQLSRRDPAVPYPAAPLDAASFTRPADPTDLALLREEYAGDYAWNFAQENMPYLRRRMAFEICTKQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q891</accession>
    <name>A8Q891_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729683.1">
        <property type="nucleotide sequence ID" value="XM_001729631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q891"/>
    <dbReference type="STRING" id="425265.A8Q891"/>
    <dbReference type="GeneID" id="5853989"/>
    <dbReference type="KEGG" id="mgl:MGL_3227"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3227"/>
    <dbReference type="InParanoid" id="A8Q891"/>
    <dbReference type="OMA" id="THMARIL"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="177" mass="20250" checksum="CA8B53F90B565958" modified="2008-01-15" version="1">MNETSPLSSLTPVQIKQLQRVFYALDKNANGRVSDSDVAEALRNLGVKDAEAEAKTCFEGAPSSTYETMSFLTMMSGVMEPFSDTRKLSEAFESFDEKDEGFVDVDMIREILNHNEAWVCKALRRRSGPMRLHQCNGSYIQINTWLVPTFLDRTHKRFDYRKFLSTLGMCEWKDLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8H0</accession>
    <name>A8Q8H0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylulose kinase</fullName>
            <ecNumber evidence="6">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729725.1">
        <property type="nucleotide sequence ID" value="XM_001729673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8H0"/>
    <dbReference type="FunCoup" id="A8Q8H0">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8H0"/>
    <dbReference type="GeneID" id="5854031"/>
    <dbReference type="KEGG" id="mgl:MGL_3269"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3269"/>
    <dbReference type="InParanoid" id="A8Q8H0"/>
    <dbReference type="OMA" id="NSCALGG"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="7">
        <location>
            <begin position="274"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="542" mass="59706" checksum="23CD8D13BDCAFF6F" modified="2008-01-15" version="1">MLDDPDAAAAPVAMYIAAMDKLWHKIQTERHWPVERIAAMSAAGQQHASVYWANGATEQLRRLDGSAPLSTQLTSKAFSRSIVPNWQDATTLTECDELMHFADTYMQGDKGASSTSTSPMCEVTGSIAHTRFTGAQILRWRKRYPEQYTNTERITLVSNFVTTLLLAGGRDAHIAPLDQSDACGMNLWDMRHLTWNKSLLSFVGSGSTQHDTQASEELGAKLGHVVLDPRYVLGRAGTWLQTRYGISSECLVCQATGDNPATLQCLTPRLGEAVLSLGTSDTILLPSQVYAPSAQYHVFAHPASCKEAAKDSTPPYFLMFVYKNASLAREWARNTYCHGTWDAFNSAMLASPTPKNGTGFFWLRPEIIPWNAHGLHRFNEHGDSIADFVDVRYNVPAMVQSQFLAFRTRILRVLEASQTRLQRVYVVGGAAENKTMCQLLADVLGCEVAKPMVRGRSAETGESIPYNYCSVGAAFRARWVWACATQSQVSFETCVLDARGPSETHAFETVACPNVVHAQAFSAYVDTWTSLEKRAMASTSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9S0</accession>
    <name>A8Q9S0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3548</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729513.1">
        <property type="nucleotide sequence ID" value="XM_001729461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9S0"/>
    <dbReference type="FunCoup" id="A8Q9S0">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9S0"/>
    <dbReference type="GeneID" id="5853820"/>
    <dbReference type="KEGG" id="mgl:MGL_3548"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3548"/>
    <dbReference type="InParanoid" id="A8Q9S0"/>
    <dbReference type="OMA" id="WTYFTST"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="267" mass="30535" checksum="A09236FEA735F058" modified="2008-01-15" version="1">MLYEALASLVPANVAQLTGPIQHWQPGVTPMSTLTSVTVASLSYVVAVLGGQAIMRHFPAVPGHYLKVPFFLHNVLLSVGSLILLLLYLEREFQLMARYGLHEAFCLRSLYFEVEMFHIINYYFKYWEFLDTFFLVIKKKKLMFLHVYHHMATAALCYSQIVNETPLSWVIICLNLTVHVIMYGYYAMTSIGIRCPWKKMVTSSQIIQFVIDVAICTYGIYHHYVPQFAPWLPYVGFCYGRPAAAFSGLAILSSYLFLFILCTSQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9T8</accession>
    <name>A8Q9T8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729526.1">
        <property type="nucleotide sequence ID" value="XM_001729474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9T8"/>
    <dbReference type="STRING" id="425265.A8Q9T8"/>
    <dbReference type="GeneID" id="5853833"/>
    <dbReference type="KEGG" id="mgl:MGL_3561"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3561"/>
    <dbReference type="InParanoid" id="A8Q9T8"/>
    <dbReference type="OMA" id="HASENYK"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="42"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="199"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="77349" checksum="8B29FA5D52B7FBE5" modified="2008-01-15" version="1" fragment="single">MSRSRSRVEEHFVGAVSPEHAQSSETGRRVGDFVRAAGGHSVITKVLICNNGIAAVKEIRSVRKWAYDMFGDERAIQFTVMATPDDLRINADYIRMADKYVEVPGGPNANNYANVELIVDIAERAGVHAVWAGWGHASENPRLPEMLARLEPRILFLGPPGTAMRALGDKISSTIVAQHADVPCLPWSGTGITETIQSTEGYVSVPDDAYERACVHSAEEGLAIAQRIGFPVMIKASEGGGGKGIRKCVSPDMFVQLYQAAVGEVPGSPVFVMKLASAARHLEVQVLADQYGQAISLFGRDCSVQRRHQKIIEEAPVSIAPAETRLRMEQAAVRLAKLVGYVSAGTVEWLYSPETDTFAFLELNPRLQVEHPTTEMVTGVNIPAAQLQIAMGIPLQHIDDVRELYGLGRVDERGQRCGAPSARTSIDFDARHQSVDTSPKPRGHVIACRITAENPDTGFKPGIGSLSELNFRSSPSTWGYFSVSTSGALHEYADSQFGHVFSYGADREEARKNMVFALKELSIRSDFHTTTEYLVMLLEQDVFVQNQVTTAWLDGLIENSVTARRPPTELAVLCGAAVKAHALAKESRDEFKRILHRGQVPPRNTVRTKFSVEFIYGNVKYQFVAKQSAPTSWTLHLQQQQQQVHVSLRDLSDGGLLIGLSGASHTVYWFDEVGQTRLVIDGQTCRMEEERDPTQICSPSPGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9Z7</accession>
    <name>A8Q9Z7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729105.1">
        <property type="nucleotide sequence ID" value="XM_001729053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9Z7"/>
    <dbReference type="FunCoup" id="A8Q9Z7">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9Z7"/>
    <dbReference type="GeneID" id="5853412"/>
    <dbReference type="KEGG" id="mgl:MGL_3572"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3572"/>
    <dbReference type="InParanoid" id="A8Q9Z7"/>
    <dbReference type="OMA" id="DVQFIRM"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000006">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="4">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="211" mass="24209" checksum="D09C85318ADBFEC2" modified="2008-01-15" version="1">MTSHWLVKAEPLSRLVKGIDVAFSVDRFEKEKVCSWEGVRNYQARKYLRDQMKTGHRVLFYHSSCKVPGIVALASVCKDGYPDNTAWEPGNPYFDPRSDPKAPQWYMVDLQFEGRLTHPVPLGVLKHLTSSDLSDAQREDVKYLSEDHLLAVANMLLLNRSRLSVQPVEYMAFEAITLLGQRGGFMNWPGKWSRTNTPDESIPPSRKRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA04</accession>
    <name>A8QA04_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729107.1">
        <property type="nucleotide sequence ID" value="XM_001729055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA04"/>
    <dbReference type="FunCoup" id="A8QA04">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA04"/>
    <dbReference type="GeneID" id="5853414"/>
    <dbReference type="KEGG" id="mgl:MGL_3574"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3574"/>
    <dbReference type="InParanoid" id="A8QA04"/>
    <dbReference type="OMA" id="YMELTQK"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="1">
        <location>
            <begin position="170"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="656" mass="75093" checksum="E9BE7EB63DE2738E" modified="2008-01-15" version="1">MRPTNVTSTMVSRNPASENFPLVSSALSPIPFTPNRSLSLQFKGERICDESVQRQLEQRIDLLKHNINSQSKLNFLLESDIRDLDSRIALLIANRMALDEFDYPQVGKNECRCHILDDKRLQLYSILFHILVTEPRHIATLCSLVSLTEMDMFLQTVMFTIYANQCDEYEEHLLLTVFQFVLSTQFKTSHDFSTVMRANTPISRMMSTYTRRGAGQTYLKNVLSRHVHTVLQTPTSLDLDPAHVLHELVREGAISGNPECVTLDHPMVQERIEARSSFLMHIANAVVNDIITSVDLVPYGIRWICKQIKSLTRKKDPDACADVIFSLIGSFFFLRYVNVAIVSPQLYLLNVESGSKHGHRALVLVAKMLQYLVNNPSHEKGCMMRLLKSFTDINRHRLTMFLNSLCNVDDFYGSLEIHHYMALSKSDRRLHISINELFFMHALVKKYLNVLAPDRGTHLGQIIEELGRSPNQLTRNENYTIDLALFSRWETPKHDLASTLMIENNMTSSDILYIETKTLFVEIMRLTSCRTRPTNLSELARNAARSGIKYLEALGRRASTKLNELEELRILHEDIQKDLMIDEIHTDFTCLSQINGLSKLTEDEKNLNSVLNALKEHHAFLQMQLKTYNDYLKNICQASNTLRGTGANSAFGSWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAA5</accession>
    <name>A8QAA5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein YTP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729197.1">
        <property type="nucleotide sequence ID" value="XM_001729145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAA5"/>
    <dbReference type="STRING" id="425265.A8QAA5"/>
    <dbReference type="GeneID" id="5853503"/>
    <dbReference type="KEGG" id="mgl:MGL_3664"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3664"/>
    <dbReference type="InParanoid" id="A8QAA5"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="344" mass="37931" checksum="7B17FE9DB4D31EC2" modified="2008-01-15" version="1">MAGHLGQCLAHYIMGSAFAAYSVILLIMMKCAVEWLRRRGFAQEYLDSWVILLWGIVNSFTEHHGGPWTHKDLQHTLMGVVWWAGGAVGIWVSRRGARSVFPAIIIMLTGWAMSGHKQAVAISTEIHALFGYTLMAGGLCRVIEICFVLNEGPSGSIPREPRPGEWFPVSIFQYLPPFLLVSSGILFMSATDEEMRWADAKGVDHVTWALIDFSVAFTLFLWFNVLIDTYVGYGGRYGLAAGHAKDEPFSYLAMEQGLEHVDEDADAGTDADADADADAVALEPYGSASHFHASASRLKEPVQAPNTYAQSMPTRELNTTPPLPPQTHVLEDKDPFDDNDQVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAB7</accession>
    <name>A8QAB7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3676</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729209.1">
        <property type="nucleotide sequence ID" value="XM_001729157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAB7"/>
    <dbReference type="GeneID" id="5853515"/>
    <dbReference type="KEGG" id="mgl:MGL_3676"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3676"/>
    <dbReference type="InParanoid" id="A8QAB7"/>
    <dbReference type="OMA" id="INADVWF"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="11">
        <location>
            <begin position="30"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="217" mass="24158" checksum="C59FD872A7FA662A" modified="2008-01-15" version="1">MIICSLPPVHGFTTALTMCGMAFASAGPHASFLEQVRKLMSAWLVATGGLILSASIAFVVLRRVLYHLSGQWDLLARVKEDQRFRALQHAICQKGFLMAALARFCPLPYCYTNLLLASLDSLSFGTFVLSTLSTAPRLLIPLFMGAKMYELSDHDIRASLDPSTRRLNSIFIFVSLALGVGSSWFIWRKTSDMLLRHEAEHASDEERTAFILDDVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAI5</accession>
    <name>A8QAI5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729277.1">
        <property type="nucleotide sequence ID" value="XM_001729225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAI5"/>
    <dbReference type="GeneID" id="5853583"/>
    <dbReference type="KEGG" id="mgl:MGL_3744"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3744"/>
    <dbReference type="InParanoid" id="A8QAI5"/>
    <dbReference type="OMA" id="PAPGVCH"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="374"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="532" mass="56899" checksum="D00BD66223CA88BE" modified="2008-01-15" version="1">MVPPSAPNGSGSSYDQLLKLPPIRSFEPTVPSSMDLSSTPPCRYPNNSPGGSSSNAIAPDDKASSTSDKQQVDATTSGLSRPQLPPSLSAPSLPNSHASTPPSPPPPAPVSNLPSHHTPYESAPTPVRANRSNDSSQSPAYGPYALPRAPGMLPWQMSSSTSLDPSTVYALERIHSASLALHDHVGELLRSQSVTSRQDEMHSFLPFVSEINHEVRGLMSTLDNRAGREAFDIAPYYPWLPGSNATQYWSQNIRDERGSKRMRCEDDKDGHVRRRSLGQHTKSEQRLVSRSDLRPSNSTDDLIYAARLGTDHHGFSSSSNPNTRSDASSYASAYGTASSTPSKGSLGHDTSVSVQQAYVPKYRKRSRAPAPGVCHSCGNGDTPEWRRGPDGARTLCNACGLHFAKLVRKRTLEYANSAPGIPIPPVTIAELRQSTNVNLNSPGVIQADDERARIASNQSSSATSLTHGRFPPRSRSESVSSAVATPSSTVSREHVYPEPAVSGSETQESLPSKGGEESSTDVVSSVKTGTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAS6</accession>
    <name>A8QAS6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729034.1">
        <property type="nucleotide sequence ID" value="XM_001728982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAS6"/>
    <dbReference type="STRING" id="425265.A8QAS6"/>
    <dbReference type="GeneID" id="5853341"/>
    <dbReference type="KEGG" id="mgl:MGL_3822"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3822"/>
    <dbReference type="InParanoid" id="A8QAS6"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="556" mass="62929" checksum="5A5D22D531DDBA27" modified="2008-01-15" version="1">MVYFSHKRVSLPPAGWIRAARFHGTKVLGTLIFEWDQSKSDLKLLLDGPHPKWRTPVRVELSEHFADQLVLLAAAYDIDGFLVNVETSLQLNPFQNPILQRLDRLHNAVRLRRWVQYFREKGQQSRPVWHVVWYDSVTYPEGQLAWQDAMTIANAPYIQAASSAFINYTWSHPERCKHGFLNPCLEHTVSMADHCLFPRYNVFMGVDVFGRNCLGGHDATKAIDLLGLHLGNEGFASGKRYNLSVALFAPGWTWEHDSPPARSWDAWWKEDCEFWEDGLHCITKYFPNRAYLWHGDSTHGYGFRTNFCLGSGTHWFVQGRNVYHDKEHGWSDQGVSAPKPTLAWPNVKYVLNESGTYVKAAVHTHLSCEDAWSGSQSLCVEVSSESYIPILALAPMPREASSRSATLRVCAKGAKIVPCIHVGSRLLRGCESIQRVNGWQLYKVELTLPEDIYENEVHVILGVSGSVLIGQIEISSSQYLEADATWHNGVLSWSDVVPWATCYEVYTVREDPVWIGTVSHTLSRNQTIMYGDEETIAQIQSVGAWPDEAPILAMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB32</accession>
    <name>A8QB32_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729089.1">
        <property type="nucleotide sequence ID" value="XM_001729037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB32"/>
    <dbReference type="GeneID" id="5853396"/>
    <dbReference type="KEGG" id="mgl:MGL_3877"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3877"/>
    <dbReference type="InParanoid" id="A8QB32"/>
    <dbReference type="OMA" id="WHANFFF"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38253" checksum="6F5B6E8B64735CDA" modified="2008-01-15" version="1">MQHKEGPPLPLTQPRDRAGRFVDQDETVFSAFLPHIKLMIVIFAAVSGFMSPFSSNIYVPALDTISKELSISRADTLLSVTTYLIFQGLAPSFWGPLSDTLGRRPILSGALVGPCIAPVVGGLVTQRWDWHANFFFLVAFGGLVNLLLVIFLPETLRSLVGDGSMRPCGIWKTIFPMRLTASSGSDLSEAPLMEKPPRFNILKMGFEKPWLVYSQLDILLLIISYSVPFSVFSVTSSIFSPTLASNYGYNHIIIGLCYLPLGAGFAVGSIIAGRLIDWEYAQAKKKHGISLNLFKARLKLGPIFNAIFCCGILAFEWCLHERVHIAAPLVIIFFTMMSSMIYFTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCJ6</accession>
    <name>A8QCJ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_4016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728849.1">
        <property type="nucleotide sequence ID" value="XM_001728797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCJ6"/>
    <dbReference type="FunCoup" id="A8QCJ6">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCJ6"/>
    <dbReference type="GeneID" id="5853155"/>
    <dbReference type="KEGG" id="mgl:MGL_4016"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4016"/>
    <dbReference type="InParanoid" id="A8QCJ6"/>
    <dbReference type="OMA" id="LWNSQHH"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000036">
        <property type="entry name" value="NADP-dependent oxidoreductase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="324" mass="36566" checksum="A940729C2AB2CFA3" modified="2008-01-15" version="1">MSQNKTLTLNDGNKIPQIGLGTWLSQPGEVGAAVEHSIKAGYRHLDLAKIYCNHDEIGAAFKKVFPSVVKREDVFITDKLWNNAHKPELVEKALDQTLQELGLDYLDLYLIHWPVSFDCDFDTLLPQENGKAKLDLQTSLVDTWKAMVELKKTNKVKSIGVSNFSPAHIDAITKATGVAPAVNQIEAHPLLPQDDVVEYHKQKNILITAYSPLGNNLRGEKKLYDYPQVIEVAKKYNAQPAQVLIAWGVRRGYSVIPKSVNETRIKTNFAQIDLSDEDYQKISNIYTEAKHTRYNVPITYDPPWDINVFGEDIEKNATHSIKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCN6</accession>
    <name>A8QCN6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-related protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728862.1">
        <property type="nucleotide sequence ID" value="XM_001728810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCN6"/>
    <dbReference type="FunCoup" id="A8QCN6">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCN6"/>
    <dbReference type="GeneID" id="5853168"/>
    <dbReference type="KEGG" id="mgl:MGL_4029"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4029"/>
    <dbReference type="InParanoid" id="A8QCN6"/>
    <dbReference type="OMA" id="GIHYPIR"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46088" checksum="536B36C2735FF302" modified="2008-01-15" version="1">MSRSNVIVLDNGTGYTKMGFAGNSEPSFVFPTAIATASSSAGKAVGTRPSVPTKPGGLTNSSLVSKRGIDDLDFHIGHEAYANSKSYQVHQPIRHGIVENWDLMERFWEQCIFKYLRAEPEENFFMLTEPPLNPPENREATAEIMFESFNIKGLYIAVQAVLALAASWTSNKVTDRTLTGTVVDSGDGVTHVIPVAEGYVIGSAIKHIPLAGRDITYFVQQLLREHYSYVCQDIVREFRRFDEDPYKYFERYDGENSVTGRPYSVEVGYERFLAPEIFFNPEIASSDFLTPLPEIVDTVIQQSPIDVRRGLYKNIVLSGGSTMFQHFGQRLKKDLSAIVSQRIAASEAASGNLARSSGLDVNVISHRMQRYAVWYGGSLLGSLPDFYSFCYDKRDYEEHGPSIVRKFSVFGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCU1</accession>
    <name>A8QCU1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LAA1-like C-terminal TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728880.1">
        <property type="nucleotide sequence ID" value="XM_001728828.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8QCU1">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCU1"/>
    <dbReference type="GeneID" id="5853186"/>
    <dbReference type="KEGG" id="mgl:MGL_4047"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4047"/>
    <dbReference type="InParanoid" id="A8QCU1"/>
    <dbReference type="OMA" id="YPQVIQE"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1811"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1964"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1975"/>
            <end position="1988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1996" mass="216456" checksum="D63FA09A7BF2BB13" modified="2008-01-15" version="1">MAADSPSSPSKSQSATLPASSAPSEHTQHASSLSDVKGHLPLLPDEKEWEEAVRQDRTDLFLLSWLVRIDSLLLEGEVRGSGALVERCLCICGSQRSGQPSISSAWNQLQPGRSVRCLVARCLVCLYRHSEAEKPPLFEVMGALRDVYAADIPTNAHLAAMHVARELIMSHPHGVGSQFSAVPICLRIIRTSSHTVLVRYYALRLLESILAHDKLPASMLKDALKTLKQALHDKAGPVVRASAVCLELVFRDATRSDIETQLASIVKVLASADRQTRTALARLAATLLIQTETMAPADEGKDPVVVPLYTAEQQMNLLHVHLSRAGSWKARVGVLQMYDALLALHGSAWLEQHLQEVFMHLVRDIATNMPIPAHESPYLCRAVHRVLDVHLRSLPEPAQERAAAYMGSNILGMWPPATPAHEAPSEAMLTLTLDATALLVAQLGELSPTLHEALYESHMRLLAHPILAVQIRAAWWLSIACDVQPLLLAPTYAELLTFMRRDMAALSTPQHDQGVSLRARLVGHSFALAALARISAKHPLYMRNDDVEDVFTLATDLLTRSGEQNALPNASAAVGSAWMLVGSLMALGTEFVRAHLPTLMNAWRQALAERSYAELDDAAWQYLLTVRHGALSSMHVFFLHGGHELLTQETARRLVVMQSHALAFLDAWERRAMFASHAPAALPILSRVHAPLLRVRILRCCTHLAQTSALETLAPHLMSMSVELLARAERWHTGSATQTAISTSTGASQSPWTVHDGVAYGMTSLLRQDVGAALDAWTPAFSTAPFQPTPVADSDTYGLDLELELDAQTPVLGALEHDATALYALAATSVDPYRILPGAPQPMPPGTAEIDAAAELFAALFAFQPRDLQIGTSEFLLAAQRRPALDKQPGRRIAVLVNSVVALLGAVRTAAHHPHRASGFANERVNAAIKGVAQRALQEGHVMLRRAAAELYGYLASLAGSGSLSMQMQFLIDQIVDTRHADGRAACALALGQIYTCVGGLRASPLTKTINSLTLSLATDPHPAVHACALDALAQVIEAAGVAYEPYVRSTLGLMTRLLSLPTHEPEGGSPGSSNLRVDWPAYPGIARVVSALVGVLGPDLQEAVSTRGVVYALLLHLVQDGGDAAAKEALLGLQRLGLVVPVLLETRVSANLLRHALSRPILAPSAASLYCQMAQRGSQWLARYGGPSLLASLLQQLDRHPTLSGVRTLVLSWLKDTAPARPCTWMDLCCTALLTPEALSFKHVNVSGSDTDETATALAPKDDTPLLSIRWRTQLFVLQCMDEVFASVQRAPEHVGSHSDARDRRVLSSRVSEILRAACSASTATHRAVRWQGLQVLRDVLESFADTRDPDFSEARLLEQFQAQLAAALTPAFGADSTPDVLAAAISVCSVYIIAGVDASPTNRILRLLGSALEQTQSSEMSRLGELPLTPNAAAYLNIAVLTAWARLAIAQRPAITNLLSPHVHTLARAWVHVLTAYAVLRADRGSSVASAWHIMPRMRPESALAPLVQTHMLLYFAQAYPTLLHALTLVFETNPDVVRATLAHDLGDASRAFLALYGLALETLCDELDRLPQTEQSMLGVVLSSLHVLVDAKYSGHFLLEDAQFDELVCVFQRALLSEDASIQRGVLRVIATLVRSMRERLLEQEDGMIHDERMPTTKLGRLWRLLMHFIHELPHQRTPRAERAVLLHACWQTLLDMVEVCGASLQLELVAVSLHILVAFARREDEAASLLTSALPVLRDLCKRACQSASANPPLVHRIMQGFMSAMIDMSDALRARAGDIVTRRSGNALVSTSLVLTCLDARVSISSEVIERLSFLLAQKLDANDDAPVVLQCIRSMVHAEPSCHSQRLCIGWCLPSLVAYTLRHLSEPAMDILLDLVCVMPDDVALRLAVPVAVQFVQSSSPGRSQASDTVLVASSNKVVNRLMELAQTHAQAFRLATQALDEDARTCLHDSLRAAVGITDAQKRPKPGSSSSATSESGNSISLRTFGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD61</accession>
    <name>A8QD61_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="14" type="ORF">MGL_4129</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728794.1">
        <property type="nucleotide sequence ID" value="XM_001728742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD61"/>
    <dbReference type="FunCoup" id="A8QD61">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD61"/>
    <dbReference type="GeneID" id="5853088"/>
    <dbReference type="KEGG" id="mgl:MGL_4129"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4129"/>
    <dbReference type="InParanoid" id="A8QD61"/>
    <dbReference type="OMA" id="AQHVTYV"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="290"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP41580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="696" mass="77361" checksum="05F6EAE08DFF07BC" modified="2008-01-15" version="1">MHSLLQYRSASGQFIGGTLLVAIQSNTKRYLNLFCEVIDRMMPDPDRDISEKDDVLDVIRHQRLERNAMNEQQEESMGEVAEVFPPTLLRRYMLYFRPPSRTASLPVRAIRGAHLGKLLSVRGIVTRISDVKPSILVDAYACDVCGAEVFQEVTGQQYMPLTFCTSRVCVTNRTRAPLYPQARASKFLAYQEIRIQEMTDQVPVGHIPRSMNVHLYGRLTRQVSPGDIVQLGGIFLPLPYTGFRGIRAGLLTDTYLEAQSIHQLKKTYEAMEPTPEMEAELAELRSDPSLYHRLASSIAPEIYGHEDIKKVLLLLLVGGCNKTMGDGLKIRGDLNVCLMGDPGVAKSQLLKYIAKVAPRGLYTTGRGSSGAGLTAAVLRDPVTDEMVLEGGALVLADNGIACIDEFDKMEDADRTAIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRVSPVDNINLPAALLSRFDILYLILDSPSRDDDERLAQHVTYVHMYSAPPVQAQDVVPPHLLRHFIAAARQCRPVIPRSVSDYVVNAYVQMRAQHKQDEERDEAFTYTSARTLLGIVRLSQALARLRFADMVEIGDVEEALRLMDVSKASLYTSARHRGDLGHDQSYVSRIFRLLREMAVHAGQEDPAHANASGLGELVLADVRARVLAAGWVEDQLHDTLQEYSSLNVLQVVGQRIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD93</accession>
    <name>A8QD93_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_4161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728682.1">
        <property type="nucleotide sequence ID" value="XM_001728630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD93"/>
    <dbReference type="STRING" id="425265.A8QD93"/>
    <dbReference type="GeneID" id="5853023"/>
    <dbReference type="KEGG" id="mgl:MGL_4161"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4161"/>
    <dbReference type="InParanoid" id="A8QD93"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="54"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="172" mass="18638" checksum="3F3E851E01DFA217" modified="2008-01-15" version="1">MDSQTVTSSGTLAEYVVHPATWLHKLSDTTDWGIGALIEPMSIALSALRRANLQLGQAFKGIKPDVAFECTGYSMPIHTCLGVLEAGGCLVQVGIGAPVNELSFSELLHRQVDLRFVMRSNSCFEDCIRLVENGVVDPSLLITHVFPIQQASEAFRTLSQPESGAIKVHIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDB5</accession>
    <name>A8QDB5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_4178</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728699.1">
        <property type="nucleotide sequence ID" value="XM_001728647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDB5"/>
    <dbReference type="FunCoup" id="A8QDB5">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDB5"/>
    <dbReference type="GeneID" id="5852980"/>
    <dbReference type="KEGG" id="mgl:MGL_4178"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4178"/>
    <dbReference type="InParanoid" id="A8QDB5"/>
    <dbReference type="OMA" id="SHHEMQE"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="779" mass="89922" checksum="7A64ECDAC378FB68" modified="2008-01-15" version="1">MSINSFMSETQQEDAEWMYPSYEDESRPAGTPSAEETPGTAGPVNNIATFTAMAAEAGSLPTLGMELLDLDNKDQVNTFISMTPHMPPECAPLFASLQKCLQMRDKYMNESLQANLYDNPKNWDAEYCAEWAAEHNVDVPAPAMQVAPNSVRIDGCAMDTVHGRPKPWRIYPPPPRPHWEQFSPAPTSTFVRESTEENGTSLHAPLEPASHANVLAAQELLESCGGVPGVFRMEHIDMPPKHELDGADVQFGMVDGVFHAWTAARDKCLTHVTPSGEWFHDLDILHSITSDGPAKTFAWRRLKFLEGKWNLYKLLNEYRESDMLKRVSHRDFYNVRKVDTHVHHSASMNQKHLLRFIKAKIKRHADDVVLCRDGEPMTLHQVFQLLGLTAYDLSIDTLDMHAHMDSFHRFDRFNLKYNPIGESKLREIFLKTDNYIRGRYLAEITREVTHDLEQSKYQMCEYRISIYGRNPHEWDKLAAWVVDHHLFSPNVRWLIQVPRLYDVYKANGNVQNFEELLDNVFRPLFEVTSDPASHPKLHIMLQRVVGFDIVDDESKPERRFLRQFPPPKEWNFAVSPPYSYWLYYMYANLATLNQWRRIRCFNTLVLRPHAGEAGDPDHLAAAYLTSQSISHGILLRKVPVLQYLYYLKQIPLAMSPLSNNALFLAYERNPFPDYFRKGLVVTLSTDDPLQFHLSKEPLLEEYSVATQIYKLSSTDMCELARNSVIQSGWEMEIKRHWLGRRFFLPGPSGNDVSKTNVPDMRLQYRNETLKQELAFVWQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDF0</accession>
    <name>LIP3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Secreted triacylglycerol lipase LIP3</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
            <ecNumber evidence="5">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LIP3</name>
        <name type="ORF">MGL_4197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Microbiology" volume="162" first="1069" last="1079">
            <title>Secreted lipases from Malassezia globosa: recombinant expression and determination of their substrate specificities.</title>
            <authorList>
                <person name="Sommer B."/>
                <person name="Overy D.P."/>
                <person name="Haltli B."/>
                <person name="Kerr R.G."/>
            </authorList>
            <dbReference type="PubMed" id="27130210"/>
            <dbReference type="DOI" id="10.1099/mic.0.000299"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Secreted lipase involved in Dandruff and seborrheic dermatitis (D/SD) probably via lipase-mediated breakdown of sebaceous lipids and release of irritating free fatty acids (PubMed:18000048). Has triacylglycerol lipase activity and is able to hydrolyze triolein, tristearin, trilinolein, tripalmitoylglycerol and trihexadecenoin (PubMed:27130210). Hydrolyzes diacylglycerols such as distearin, dilinolein, dipalmitoylglycerol and dipalmitolein (PubMed:27130210). Mostly converts monoolein to di- and triolein, while free fatty acids are only produced in low amounts (PubMed:27130210).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EC" id="3.1.1.3" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728718.1">
        <property type="nucleotide sequence ID" value="XM_001728666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDF0"/>
    <dbReference type="SMR" id="A8QDF0"/>
    <dbReference type="ESTHER" id="malgo-a8qdf0">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GeneID" id="5853009"/>
    <dbReference type="KEGG" id="mgl:MGL_4197"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4197"/>
    <dbReference type="InParanoid" id="A8QDF0"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="BRENDA" id="3.1.1.79">
        <property type="organism ID" value="13511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013435430" description="Secreted triacylglycerol lipase LIP3">
        <location>
            <begin position="20"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="115"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="360"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="W3VKA4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18000048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="453" mass="49439" checksum="D089B11FC2574391" modified="2008-01-15" version="1" precursor="true">MKLGIVAFTLISFAAQALALVARENLPKPQNDPFYQPPDGWESKKVGTILRSRKVNINTLVKDNLKEAWQLLYRTTYRSDDEPTTTVTTIMVPHNAQNDSLVLYADFEDAGAPQCAPSYTWRAGLLSDTSSIFNVGIAMLYLQEGYIVTMPDKEGNKGAFGSGHVEGRQSLDGIRATLAFDKIGLNKNARVVGHGYSGGGIQCGWTAALKKSYAPEINSVGWFTGGTPSNVTALVEKINGGPFAGYVAGGLGGVISTYPDVKAYTDKVFTKQAQKDLEFPRKHCQEEITLHFLFKNFYDKSFSTVGKRFLYEPVVQKALNELTMGTNPDFTPDTPVLMAHGVSDEVAPYEAAHETYKSWCKNGADVEFVSFANPVSAHGVTTVTSTVPGFLWNRDRLQGKPVQGGCREIKNYDVGVNSHALGEDFESALGLLKGLLGDKIGPNDEYLKDALHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRC4</accession>
    <name>A8PRC4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732245.1">
        <property type="nucleotide sequence ID" value="XM_001732193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRC4"/>
    <dbReference type="FunCoup" id="A8PRC4">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRC4"/>
    <dbReference type="GeneID" id="5856551"/>
    <dbReference type="KEGG" id="mgl:MGL_0020"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0020"/>
    <dbReference type="InParanoid" id="A8PRC4"/>
    <dbReference type="OMA" id="CKIYGMI"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="295"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39270" checksum="0BDA9CB921C51856" modified="2008-01-15" version="1">MLESCSLFAAEFSTLFHPFGTEYDIERRHPETVQTLVNLSGYVTYIDDIRETLRPEIELIETRVVAPIQEVEQVLKSINKAITKRDHKLIDFDRHTNSYTKLKEKQNRSAKDDQHMFKLEHDCEAAAADYEHHNNLLKAELPQFLAMATKFIGPLFYSLYYMQLNVFYLSMEKLKSYAEGRFDLSENNLISHEHKFAMDMSHILAEFDSFSIQKPGPPTARILQMAKAGAPLSSRPKGLPSAVSAPSTTGTGAKVGAATVPPTATATSAAAPPPAYTPSAAGAATVSDTTKPSALAADYVVALYDYAATAEGDLSFRAGDRIEVIKRTPSTEDWWTGRLHGIEGVFPGNYVREDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRG3</accession>
    <name>A8PRG3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732271.1">
        <property type="nucleotide sequence ID" value="XM_001732219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRG3"/>
    <dbReference type="FunCoup" id="A8PRG3">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRG3"/>
    <dbReference type="GeneID" id="5856577"/>
    <dbReference type="KEGG" id="mgl:MGL_0046"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0046"/>
    <dbReference type="InParanoid" id="A8PRG3"/>
    <dbReference type="OMA" id="DWGGRGM"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="106"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22617" checksum="F38F43FDAFDCB162" modified="2008-01-15" version="1">MRDEVLKLLDQRKQIESQLAKHQDSLKSHHVTMSTELLDSEGFPRSDLDIPTIRTSRQQIRMLLHDRELVNERIEQLLPLALKCNDAHASSPSPSEQSVQQASSRLRDQSHLLAVRSVRPQSPASKAGLQAGDILLTWDELKPITSEHMSQLPSRLHEGVPISLDVRRLQPDGRHVQIQLTLVPSSRWDGNGLLGCHIVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRL6</accession>
    <name>A8PRL6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="5">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0080</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732305.1">
        <property type="nucleotide sequence ID" value="XM_001732253.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PRL6">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRL6"/>
    <dbReference type="GeneID" id="5856611"/>
    <dbReference type="KEGG" id="mgl:MGL_0080"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0080"/>
    <dbReference type="InParanoid" id="A8PRL6"/>
    <dbReference type="OMA" id="CSRPWLA"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein,Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="14">
        <location>
            <begin position="683"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP45091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1431" mass="157987" checksum="4D7E636DF1E282C6" modified="2008-01-15" version="1">MSESSLQAVWHVVRSTVRHAVAVDMEKVPALSQESVGQNTLLLQHITSAAEIGTVVRDLTMSMPNELIVVVMRAKSSSLLRLVPHLPALAKLPVVLHVETCMHHADVLQLRQSGVAMVYSGAGDAAEAQAYALFAHKLAASTQTGVIHFFDATHRQDSSCASLADTSKFQSSVQVLKERRDLSDATIDQTLADVNALLGTKIAAVDLHGHTSETTDTMAVMLGGAGAELAESAHVPVLSVHVVRPLLPTRLVGMIPSSVKRVAVLEHSAKRSTRLPPLLVDVANAFQHVPERTMPTLLSGMLGHIQSDVAKAGQTLSQACHAASSSDANSASKSSFTIGEFASSSDEQAISVRKTLAHERAYHAMLEMLFKERLDVVNAPTDEAQHGAASPEYALGIVLSRLKQADALVGAAQRMSEASSTPDALRQALRTWLSVRGDSSRVSAAADDVRANLKGVAGEEADVLRAHEPLLIPPSRWIVGNDAWAYDTGMGGVHHVIACQQNVNMIIFDSVPYTQRDQVPLHQRKKDIGLYAMNYGNVYVASTALYSDYSQVLRAMMEADRFDGPSIILAYMPYLTSDVPALDVLRETKLAVDSGYWPLYRWDPSAAAESSGRAVFHLDSVRIRQQLQEFLDRDNHLSLLARERPELPYDLAASQGTALREKQQQKAKEAYDQLLGSMQGPPLLVLFASDAGGAEKVAKRLAMRAQLRGLSARVLAMDDYPVDELASEQNVVFVTSTAGQGEPPQNGRLTMKALAKQPTGMLNEETRFAVFGMGDSHYWPRPEDAHFYNKPGKDLDQRLVQLGASRMVSLGLGDDQDADGWQTGYKAWEPQLWKALGVDSVTVTEAEPEPITNEHIKVASNYLRGTIAEGLQDTTTGAICETDTQLTKFHGTYMQYDRDTVEERKAAGLEPAYGFMIRVRMPGGVCTPEQWLQLDQVTEQYGGIKSLKITTRQTVQYHMILKRNMKAAMQGINRSMLDTIAACGDVNRNVMCSPNLHLNQVHEEMYEFSKRLSDYLLPRMNAYHEIWLDKGTDSSSKLLVGGALQDYEPLYGPYYLPRKFKITLAMPPRNDVDVFAHDIGLIAVSDEAQTKLLGFNLAVGGGMGVTHSMKATYPRLASVIGYVPVDQVCEVCRQVLLIQRDTGNRQNRKQARLKYTIDKYWGGADNFRRELERRLGYKLEEARPFHFDTNTDEYGWVKDMNGKWHCTLWLENGRVIDEPGLPFRTGLRELAKFHKGTFRLTPNQHIVVSDVDEADKPKIEAHLEEYKMNNWEHSGLRLSASACVAFPTCGLAMAESERYIFKLVDKLERIYLANGLKHDEITMRMTGCPNGCARPWVAEIAFVGKAPGTYVMCLGGGHAGQRLNKIFRESVTEKEIVEIMEVLIPRYARERLNGEPFGDWVIRAGIIAETTHGAAFYDKVDTSKPLAALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRM5</accession>
    <name>A8PRM5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732311.1">
        <property type="nucleotide sequence ID" value="XM_001732259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRM5"/>
    <dbReference type="FunCoup" id="A8PRM5">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRM5"/>
    <dbReference type="GeneID" id="5856617"/>
    <dbReference type="KEGG" id="mgl:MGL_0086"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0086"/>
    <dbReference type="InParanoid" id="A8PRM5"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="7">
        <location>
            <begin position="25"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="377" mass="43065" checksum="31CA7B40B0BA875E" modified="2008-01-15" version="1">MQRSAMRGPLEEPVKGKIQVPAENLESEMLRTQLVTWRGILTKLCTAWSCHVQAPSMYREGFELNAMMLGDTLVLEEVPPTMMQWQAMQHERPKPKRSQRATYYGYNFESYCTKETPRLAAGSAASLPLAKVPGWSGDVNTNVQWCHIMKTKLGNNRIIIGGEVDCVETLDAGTEREREGVVELKTNLHVDSADDQNRLDAKMLKMYMQSFLLGVRTIVIGFRDQQGMLLSHKSFRPADLPRLVRGHAVQWNANDNLAFGSLILDFVRDTVRAETERWSYCMSQRVRENEKSLGAYAWRVHRTTNSFLGHLPLPAPQDAEQEYPVFRVSFQPPFSHVTVRYVTPYELGLDGRRRGRCGLVPTPFYLWATMPMTHLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS31</accession>
    <name>A8PS31_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732408.1">
        <property type="nucleotide sequence ID" value="XM_001732356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS31"/>
    <dbReference type="GeneID" id="5856714"/>
    <dbReference type="KEGG" id="mgl:MGL_0183"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0183"/>
    <dbReference type="InParanoid" id="A8PS31"/>
    <dbReference type="OMA" id="VACIMEA"/>
    <dbReference type="OrthoDB" id="3345138at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1001" mass="107755" checksum="1492A16A53C3A394" modified="2008-01-15" version="1">MKQDDVHARIDPDAEYQKHRLHVWAHAGFDGSMVPDKPVAWSRQNLVAYGTSDEHGACVLIVPSACAVHGGKVNASQVVARLHPPPRAPPMATSTPYELDAPSLVSFSPCGHTLLAYFPVMPVLTTNEPPVPSASLELSTPLVLPVDQSAAVSPSANAMNASMSAATMSAAINTAGASTNASAGASAFTSPAMTPLATPRGLVRTPPGHSTSPGMDALGMGMGSATTSLLPYDHGVLCIWTRTSPSISATDQWILQQWFPVSLPVSTLSTSGASPAAASATAATGTASSLSSVPTAAATGASATTPPAAPSTGPSSLSKLSGDMIDVCWLDSARAWKCTETDFVRAPSSGPSTSVPAAGLPLDKSADEQACVVVSRVGQVVFLHRVHEKSMFRIHIGCLQVPGVYPPPASYEPTTLESVFSAMEIRHVSMATMSDAPILLVAYQSSISGSAMFVNMTELVFELNGDLSYFFINPQSSVTMRSLEEALSGTKHRYQVLTSMSWSRDAGGDLALLFAVATDEGASEPVWSSRSLRDTMLYVWDVRQSQNKRVDELRCIFESSPSQVASDETDKAWRITPLTLRHIPGLVLSSIIPACSPVPHAHKIYATAFVMDHMDREIWGTIDTKTYEWTSLEVQVPPHVLMRSSLALSPCGVLACMLIRPGRQVGCLCLPIQSHSIPTLGRLAALSLLRHATPMDVVHFLLRHHALTHDFIIAMVQATANALAFNDNHNNPSDAALLTLTQTKLVLPLVLALTSECADTSQRLLHASTCVFVSLFHMYQELSIARHDTTNARFADLLGHPAYASFHPSAVWTLARILQTLTEWLERALCTAMQCNMPGARPADVPADALLELCLHTNARRLLCEVLSGVCVYTTWIQQLTNESWLSLLGADVRTSSSKCDAAIHRLWNIQSHVKDILNATPLVLEHVLPFFSVLPWGMDDVAAFWDSWLGIRALHASDAVFDHARNAFEACDRAILDHVALVERCARPAQHVPPPWPYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS35</accession>
    <name>A8PS35_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732410.1">
        <property type="nucleotide sequence ID" value="XM_001732358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS35"/>
    <dbReference type="STRING" id="425265.A8PS35"/>
    <dbReference type="GeneID" id="5856716"/>
    <dbReference type="KEGG" id="mgl:MGL_0185"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0185"/>
    <dbReference type="InParanoid" id="A8PS35"/>
    <dbReference type="OMA" id="FELWPAM"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21799" checksum="D01DAE3A28F15A5D" modified="2008-01-15" version="1">MASSTAADKPANTPSNEQVQFARSVYIILELWPALRQAVLEQWGGEYSEEKREFLLSYVCDEYGNGGANTKPDLDDLTELIESYVMEEFDCELEDDSAALVAGHICLAHKGVFIDGKGDELLKELEATLVRIKPKHAPSAVKNDVETLDNDEVDERDMHESTSSSHQTHAHASPQPTQPIIDEDGFETVQPRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSJ6</accession>
    <name>A8PSJ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732494.1">
        <property type="nucleotide sequence ID" value="XM_001732442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSJ6"/>
    <dbReference type="GeneID" id="5856800"/>
    <dbReference type="KEGG" id="mgl:MGL_0269"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0269"/>
    <dbReference type="InParanoid" id="A8PSJ6"/>
    <dbReference type="OMA" id="IMMAWAF"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45606" checksum="4121E37853AA5204" modified="2008-01-15" version="1">MPPKREATPAERAQQLLKRARSSPRSSGSDGGNVTSSSWDDVLVPLPRLIHALHTVAGISVVDSIGIVRVLADKKRQSIAHLRRISAPELEEIGAPCTGSTRDRVVQTLQRLAHDDTMSRGINALTDLERTSKQQRMREEQRLRRDWGDVRASEPALDEKSFAFDHVLAETALKGRRVVVNRAPVMTAWAVVVLEAMGFATNEALSLAHCYVSQTAEARARNIGIAGPKRPASEQHLMSENQPHIEFLRVRIPVFRLRNGEYRGLHAGEVMPPSRAYDYLHRSMFQMLPHVMGALTLLANSYLGPDGNADRLHAAAYELYTGFRPETHGEWGKRASLSLDTILALRATAEKEEVPQDLKREEKHGLPFLTEAECDVKRDNHIKEEDHKRPNNATQSHIMDTQFKNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSL6</accession>
    <name>A8PSL6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_0279</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732504.1">
        <property type="nucleotide sequence ID" value="XM_001732452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSL6"/>
    <dbReference type="STRING" id="425265.A8PSL6"/>
    <dbReference type="GeneID" id="5856810"/>
    <dbReference type="KEGG" id="mgl:MGL_0279"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0279"/>
    <dbReference type="InParanoid" id="A8PSL6"/>
    <dbReference type="OMA" id="FQNEWEH"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="18">
        <location>
            <begin position="876"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP45290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1242" mass="140256" checksum="8117EB00EC3349D2" modified="2008-01-15" version="1">MSHPHDVCADLRCTTCCDEPSGALVDTFDVEPLSLPRKMSPSKNTVYNKKQKTNPSPLTLSSTAHVLTSTPPDGTKYQQPQAPDFIDMPSPALVPKALTVSAVLSRSGQVHALPSRQNSLNESTNTLRKRFSTSSSQSVSETQTLEEFPFDPKKKQNQADDLMSMMPSIFRDLWRQGTEHFLSNKNEGESGGASRSQRAGKYHTGSALEAIGALFLREDSAGRLDQLSLNRSKNAKRASVSQMDLPLWIRHIEAGPLILFAQHTGSRIANWFRQMTQTEQNKKPTPIQPWFTDDDDLPETPLLMPGGFVRDDSDSLMLPPPLLDDQSNDAWSFEGLLGVRRMREQLQRKQYLDAMSKRNRPAHRVDAWTAFTNFVRSAKASEARAASAQARRRSLDVPDKYKNLGWLWPHGSRKGASSTTTFSASQPLSEVQMHGQAACDDALCARPHTKTKDDQTLSFHRSETWRASRRMSLESLDLAMSHEQERENHLAGHSFCQRITPKSMLMQQDTASMTSGVSSLLRESRSSVAADTTTLGVMWILWSYVFVSVAFVPDFVVFFLAHTLDLVMDSFEFLSYAVWFIRWVWRNVMGETVLGRICIEAYFMFQNEWEHVIREDHEESANRMRLVFGIPLSFRPRGISTFQVLRGFIELACIQSVTREQYQREGAGLVRLEYWHKPETASFCSPAASVKHTPVSVASGENTPARCEEHVSSRQAYEHGNKCKVMNIRYGGEEYDNQEDYDDDDDNDDLVVTSQSVDILELSRSQHASTGGGDAPSYSRDYSRVLWDEDNSMLVRNIKWASQLAMSAYGLRVLIVDLPPVFTPSGKQLPRQTFAHLSRLKADDVLHADIQTLDLEATYAPTFYVVRDMRRKVVCVAVRGTQSFADIVVDLDMKTEDITSSLAEWRGIPVDENTERYLYHAGIWRAAKTLVSPGSTLFRKLCETLHEHKDFGLVFVGHSLGGAIASAATILLSEYHIDAPGTDPRKGIWRTTSQDGFPGGRPIRAITFAHPSTLSHTLNKRTTYGSVPLVVNVILGSDIIPRFGHGQLRELRRVLGALTRVRRRRDMVATTISSNPKHMQEDQEFSVHIVRRFWDWLSICRTEKPDAVMLDRKKRLEDLFWRLRCEVEKDLYVQAKNRFEQALAQHMLASSVPLSPWVRAERYDAPLHTLSARRQRLDYATLKSETVQGGVLVPAGRNLWLSNGELYDITNPLAFFSLPVLHFSMFADHFPAAYEEAILALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSX6</accession>
    <name>A8PSX6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732558.1">
        <property type="nucleotide sequence ID" value="XM_001732506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSX6"/>
    <dbReference type="FunCoup" id="A8PSX6">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSX6"/>
    <dbReference type="GeneID" id="5856864"/>
    <dbReference type="KEGG" id="mgl:MGL_0333"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0333"/>
    <dbReference type="InParanoid" id="A8PSX6"/>
    <dbReference type="OMA" id="PLAQWYT"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="127" mass="14669" checksum="D29E897299802042" modified="2008-01-15" version="1">MASKSISLAKFIKSSPTLLKLVQPVANAYAHAAGYRQMGLRYDDLIVEENHQMQKALSRVPPLEQYDRVYRMRRAVQCSILQHDLPKDQWTKPEDDVRYVTPLLEEVQAADDERLAFDTMKVQAIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT83</accession>
    <name>A8PT83_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732608.1">
        <property type="nucleotide sequence ID" value="XM_001732556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT83"/>
    <dbReference type="STRING" id="425265.A8PT83"/>
    <dbReference type="GeneID" id="5856914"/>
    <dbReference type="KEGG" id="mgl:MGL_0383"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0383"/>
    <dbReference type="InParanoid" id="A8PT83"/>
    <dbReference type="OMA" id="QITRAIC"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="503" mass="54097" checksum="08C85E207999BC82" modified="2008-01-15" version="1">MLGVLRTALRPNARASQRCFSTLSVRFQDASRSKIMTPAAAVADIKPGAKVMVGGFGLCGVPRTLVDECAKRPDLKDLHVFTNNLGTPNHGVGVFGTRRMMKSVTGSFLGGNREVGDQFFNGEVQLNLVPQGTFAERIRAGAAGIAAFFTPTGYGTAVQKGELVLKYEKKDGKAVPVMTSKPREVRSFDGRDYILEEAIHAEYALVHARKADESGNLVFHSTARNFNDPMARNARITIVEAEEIVPVGALSSDEIHLPSIYVDRIVKAELPLEVEKVCLSKAEDEPRKFTSREVIASRAAKELSDGMFVNLGVGMPNLVPSFLPKDVRVHVHTENGLLGVGPYPAKEEDVHTDIINAGKESITELPGAAAFDSVASFDIVRGGHLDVTMLGALQVTANGDLANYMIPGKFVSGMGGAMDLVSSPDSTRVIVLTDHTDKYGKPKVVANTELPLTGVRCVSMIITDLAVFEVDRKNGGLTLVELQPGATIEQVREKTGAPFKEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTC4</accession>
    <name>A8PTC4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chorismate mutase</fullName>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732627.1">
        <property type="nucleotide sequence ID" value="XM_001732575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTC4"/>
    <dbReference type="FunCoup" id="A8PTC4">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTC4"/>
    <dbReference type="GeneID" id="5856933"/>
    <dbReference type="KEGG" id="mgl:MGL_0402"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0402"/>
    <dbReference type="InParanoid" id="A8PTC4"/>
    <dbReference type="OMA" id="ATCDVNC"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="293" mass="33671" checksum="9C2763F6E23D27B1" modified="2008-01-15" version="1">MADSINFHNATVEDILSLDNIRATLQRMEESIVFRLIERAQFGHNSCVYRDGAFPELVEKENWTGSWLAWSIKETEKWHAKLGRWLAPDEHAFTPIEQLPRPVLKPNDYPDILHPHHVNVTEEILAFYTQDIVPKITQQEGKPEDDRQYGSSVVCDIEALGAIARRIHFGMFVSESKFRSDPAAFVPHIRSRNIDALSGLITKPAVEEVLLARVRQKADVYGQNLDQTSTHHPGTERRKIQSEDIVLLYQKFIIPLTKKVEIDYLLERYVRVCVCVCVWRERSRGSDNEGLVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTK5</accession>
    <name>GET1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName>Protein GET1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Guided entry of tail-anchored proteins 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GET1</name>
        <name type="ORF">MGL_0439</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with GET3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WRB/GET1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732664.1">
        <property type="nucleotide sequence ID" value="XM_001732612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTK5"/>
    <dbReference type="SMR" id="A8PTK5"/>
    <dbReference type="FunCoup" id="A8PTK5">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTK5"/>
    <dbReference type="GeneID" id="5856970"/>
    <dbReference type="KEGG" id="mgl:MGL_0439"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0439"/>
    <dbReference type="InParanoid" id="A8PTK5"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000388600" description="Protein GET1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="149"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="222" mass="25366" checksum="4536E5BC9354862D" modified="2008-01-15" version="1">MYITNDEFRVFYVRIVRFSASSKLSSMKKELFETRQLMNMTSAQDEFSKWAKLRRRVDKLSSQVDEQNKSLASSQFVYSIMFKSFMFVLNSAIPFVLNWYYKRVPMFYLPPGDWFGPMGYLFSFPNAPAGAVSSTVWTTVCGRVLALVGEYARELFVKDAYLVAEPPMTTEKSSGDKETTSKLSTNKPAAMTGEKFDFGKEVKEADQPQGILKQRRANKSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTN4</accession>
    <name>A8PTN4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732677.1">
        <property type="nucleotide sequence ID" value="XM_001732625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTN4"/>
    <dbReference type="FunCoup" id="A8PTN4">
        <property type="interactions" value="711"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTN4"/>
    <dbReference type="GeneID" id="5856983"/>
    <dbReference type="KEGG" id="mgl:MGL_0452"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0452"/>
    <dbReference type="InParanoid" id="A8PTN4"/>
    <dbReference type="OMA" id="QSRHNME"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="301"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="862" mass="95243" checksum="6A76A97DB7801C1E" modified="2008-01-15" version="1">MLNFTPLSGPYAPASDIRGDNAGGGGGGSSERSKALSYLLEIDQCRILLDCGAPEDLTFVDDTQLKQEGSHVWRGTLPDILERIGPTIDVVLLTHAEMSHLGLYAYAYANYGLQCPVYATLPVQTMGRLQMLEIVRSWRAEVDANLTSSKSEANSGLKRYIPTEAQVDDAFDAIRPLRYLEPTPLDGKCAGLVLTAYNAGHSLGGTVWKLRSPTVGTIVMALDWNHHRERHLDGTALLSVGAAAPLAHAIGRPDVLITDIERGLFTNARRKDRDAALLSQIHRTLTSGHSVLIPVDSAARLLEILVLLDQHWAFSYQHQRFPLCLVSHTGQEVVERARTFMEWMSREWAIQLLDAPEASSRRKTTSSSSSSSAATAKSPLDFSGLRFYSSVEALHQALTPSQVKVVLATPPALSHGLSRQLLPEFLCDPDALLILTSRGTPSSLVRNLWDRWNAKQADRDAWRQGHVGVPVSVGGQLSYELRRRVPLAGDELRTYVERQKAREAAADAPRARIQQPQREADDVDDDDASSSDSSSDDEFDGQPSRLPSTRTIAPERAQMQLNAAAPEPVGMSFDIFLRGQVSRDAVHYRMFPHIERKRKVDGYGESIDTSRWLARRRRLEAEQEEQLNPERLKPQKKRTRPVDVPCKYTSDTLNAAVRCHVLYVDLQGLNDGRALTTLVPQLQPRRLIMVNGDEATTLAVRAKLSRTHDLYTPDLGQTVSVGGLSNSYSVRLGDALMGSLRWHPMQDYNIVHLHVSPDFASDSDTPTLVPVNDAATVHTAQAPSTLYIGDLRLPALKAYLARQHRIRADFAGEGVLVCGDRDERNVTVTKQGTGRIVVEGSLSTNLARVRQSIYQLVAQVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU20</accession>
    <name>A8PU20_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beige protein homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in protein sorting and cell wall formation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732742.1">
        <property type="nucleotide sequence ID" value="XM_001732690.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PU20">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PU20"/>
    <dbReference type="GeneID" id="5857048"/>
    <dbReference type="KEGG" id="mgl:MGL_0517"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0517"/>
    <dbReference type="InParanoid" id="A8PU20"/>
    <dbReference type="OMA" id="PHEQIEW"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="1422"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="1577"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1998"/>
            <end position="2039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00054699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="2243" mass="248251" checksum="95AE7389DFE598E0" modified="2008-01-15" version="1">MQEVATEIHTLLLHNGGRRAPVYEGFGECGGFLAIGRLLAAVQRESDEANGPTKAHGSQLLFLALSILTDAITHSRDNLLSFEQILGWDSLVVSLNDAVSMSDRVVALLFGIGVGDVAEGVKQFRGVSEALASGQCGASQDVDFDDGDLDAWPRWKTRAIIHPHALYCALRLADSDTSASSYVRHTTYILLYDLLRTSIRNAVVLSRTAVLSRVLGAWMKKRPVPWEERVLRLLLQDGIKNAKDIRAVFAHLLQTPSLDANCDLLDLLYDIALAVHRPSSLMFEAFDEASASTTAGVQLSALDRPFPPDDARSTGFTLALTLELIEVQHEMPAVLDILQLGPEGASLRISIDLGLESLVYKPGGLGQGMYALPRTKLALRTPHHIVLTHAKSAPNVESTVHVYVDGQRACTLQVPWPGAFPHPASVSLGAIPVRSSGRSYVMWSLSSAFLHDRVVSSSVPRLLHELMPLYTGNLQGPLARFLTYSGMAHMQARLDALAEASDPETLSQAYVALRTAMYSAAADIFPLSGFYFHLQAAHTLRTKSAVLVLNQAVARISDAARVAHGHGVLQGLPTVRHPRALDEAVWGIGGCAVLLALIERADTSRALVHVVRLFLRLVTHSWRLAEDAERLQAYGMLGALLRSQLHMLTPDIVHLLEEAIMPDGRLANIPLYRTVLLDTSLWAHAPYDVQLAYVVHFRRVLPLGSRRLRDVHLVRRIIQFARAAPFVPVELLTDTVKTALEHYFRPRNVQATMHFITMTLGQTAPSPQALGASRARTDADSPYPPIVCAATLVPRCAKPNTRTLVMARAWLDVLVRMLSDDTKRVAMVAELVHAKWLMILARPGLAREDVPNVLELIGMLLSASPSLAQTWTRLGGFRVLERTLPMYWDVPCVMPWMWTLFLGTRLPKSSLFRTFAPRAYDQDICHAQALRVIVQCLTHGLMACRFAPKKRRASLPMALVDTTRLAVLEDSVRLLVAHSRNESVRALLMLAPTLVSLLRATAPRFIDEPCGPRVAALCDNILDMLAARIAELTLSSHTLTLLHNLHSAMPTPDPLMQSRLCISVYTPLFVHLDRLIRERTVLRHTLELVSDLLEMASNESLRSLLLQLRIFDLAQLVVYAPPNLVSFKTRMQTTLALERNVLHAFAAQEASTALAFCYEARSFMFTDASDLGFIQCVVYHAWLVQRASADRHACLCLTFIGANWPDLVELPLDQVPDPLPFASTWASTFASQQAFLTSLCRNRVKAWTPHVSPQVLNKLQVHERIGQWHAALRENDALRAARNAQDVREDVAFIRRQWTESRDLLRLQSSPEASGNWCLDPTEGPGRARIKLWAVPQHVSCVSVSMPHAPDMHLHVSEQDATPLPELVDINTPMEGMPSDALTAPFSGRSAHAASAAVMAPAPIPPPEEFEDKVRCILRTLEPGESVEDLLNTSRVVGIDLQSSLLIVGTRHMYLLDDYFQRPNGEIVNVWDAPSHERDALILAAGVGQITQSNEPVQKWRWDRLRLCLDRAWLHRPTALELFSHDGQSCLLVLSTQAQMKRLKHIVRTKVPHVFLDSEALVEGIRELPLAPARITGVVLRRAPVGRETLAWQERRISNADYLMILNTIAGRTMNDLTQFPIFPWVLADYDSASLDLERPECYRQLDKPMGAQTPSRHAEFVDRYEQLQQVQLEPFHYGTHYSTATSVCGFLVRVMPFSQILLSLNGGSFDLPDRIFASVGSAWASASERSRADVRELIPEFFFLPEMFVNMHGFNFGTTQAGVPVNHVVLPPWAQNDPFLFVQKHREALESDYVSEHLHEWIDLIFGYKSRGPEAVAATNVFHPMSYADSVDLEGIDSLLERQAAAQVVHNFGQTPTQLFTRAHPPRPPRLDPEPWHATADLLLYPAFLLQGRFPVTHAPGPVIHISGEPNTLIASTRDQIVLAGTKLSLSFGYVDNSVRFIDEEGDLLAMLEHAAVGRISCIAALSDMVVFGSDDGMTQLYALQLPSPHLEMRASLCGHTGAVLCLAVSSTWGIAVTGSADQTAIVWDLHRHRFVRQLTEPDQPVNLVAIDHQRGWIAAAAGFEVWIWSINGVLLVHQSTRSATNDPPSSMEFVAREFHVGKLGVLVTGHIGTIVLWDIVSNHARASPPRWCLEKSIIHKVRDAPAKITCIYSPCASVLCSGDEMGQVYTWALPGSAIVPPHVQEQCIGRCERRFGFLDVKRLCQGCAGLVCNKCSGSYAGGQLRLCKPCSITLGSRGMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU25</accession>
    <name>A8PU25_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-NAD kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732746.1">
        <property type="nucleotide sequence ID" value="XM_001732694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU25"/>
    <dbReference type="FunCoup" id="A8PU25">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PU25"/>
    <dbReference type="GeneID" id="5857052"/>
    <dbReference type="KEGG" id="mgl:MGL_0521"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0521"/>
    <dbReference type="InParanoid" id="A8PU25"/>
    <dbReference type="OMA" id="CHIVRAA"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29143" checksum="12F576CF3AF5C737" modified="2008-01-15" version="1">MGTLGFLLPYDIQAFPVILDDVVHSRFMLALRKRMCMALWDKSPGDCLWLPGEQACRELHFMNEVVLHRGREPHMTTMDAFVNGEHLTRTIADGLIVSTPTGSTAYSLSAGGPIVHPSVSTMVLTPISPRSLSFRTILLPDSAQIQIFVSPDSRSPAEVSVDGRTVHTLIKQQSASVQMSPFPIPCITFSPECNFARRSGSLSDSSDAPMIHDGWVHDINTLLRFNTSFTPRGHVLSDEQRAEAAYAGTVRAKLAAQRKKQTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUD1</accession>
    <name>A8PUD1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732066.1">
        <property type="nucleotide sequence ID" value="XM_001732014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUD1"/>
    <dbReference type="FunCoup" id="A8PUD1">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUD1"/>
    <dbReference type="GeneID" id="5856362"/>
    <dbReference type="KEGG" id="mgl:MGL_0659"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0659"/>
    <dbReference type="InParanoid" id="A8PUD1"/>
    <dbReference type="OMA" id="WSFYYWF"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="184"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="62338" checksum="BDCFE9F68373B686" modified="2008-01-15" version="1">MIQDPWRDASHTMSSAELKTLWHALNREPLMIAYFIDMRMPEHLHRIDANIYAFLDSVPAAQQALVFVDPSQHCEAPGWPLRNILTMLHVRYGIHECRVLCWKEPMGDVPHDHARSMMACLSYQHDTSDACVDCIIQRANAPSKPDAVGWERDVRGRLVPKLVALGEMLDPQFLADQAVDLNLRLMRWRMVPDLALDTIQSAEALLIGAGTLGCYVARTLLGWGVRNITLVDNGRVSFSNPVRQPLYEFHDCLDGGRPKAVAAADALRRISPGVHAQGVELAIPMPGHAVPSSLLRQTREAVESLEALIRRHDVVFVLTDSRESRWLPTLLGAAHNKVRSWRDLPCLQDHYTHTFAVSLSFTLFPVQLVINAALGYDTYVVMRHGTSSERVGCYFCSDVVAPSDSQTDRTLDQMCTVSRPGLAAIAGATAVELMVSILQHPHTQSALSETTDDDEKDSERYADTTSDGKYKPVHDESVALPHQIRGNLGSFTSHTMESQAFEQCTACSPPILSAYEHNGADLVCAACDDPSCLEHISGVQALKADVDARAVDIAWDNEHDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUG5</accession>
    <name>A8PUG5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger ZPR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0681</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732088.1">
        <property type="nucleotide sequence ID" value="XM_001732036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUG5"/>
    <dbReference type="FunCoup" id="A8PUG5">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUG5"/>
    <dbReference type="GeneID" id="5856394"/>
    <dbReference type="KEGG" id="mgl:MGL_0681"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0681"/>
    <dbReference type="InParanoid" id="A8PUG5"/>
    <dbReference type="OMA" id="FREVVIM"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="260"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="490" mass="53663" checksum="6094905E6A7DA91B" modified="2008-01-15" version="1">MHEIESLCMECGKQGITRLLPTYIPFFREVIVMSFSCPHCGNRNSEVQSAGEIQPKGCTYTIHITTKKDMNRQIIKSEFCTLSVPELQLQIPARRGQITTVEGILQDTLRDLGMDQPVRKHLQPDVYEKIEDLCRRLREMLGERASDETDVSATATEDAQPLRPFKVVLDDPSGNSFVEYTGPIESSGGADVKWSKRDYARTKEQNIALGIMGDPQTQSQEGAAGSQGAENGGANGAGGGFDKETGETEFDNEQIYTFPGTCSSCNAPVNTNMKKVNIPYFKDILIMSTACDHCGYRDNEVKSGSAISDHGRKLTLRVNDSEDLSRDILKAESAGLSIPEIDLYLAPGTLGGRFTTLEGLLQNVYDELYEKVLLRGDSAAQKDVNAFEGFLGKLKRAISAEACPYTVILDDPLADSYIQNPYAPDPDEQLHVENYTRSFEQNEVLGLNDMNVDHYTKDASGEAGMTQKQTASPKNAATPSATDATPAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUZ6</accession>
    <name>A8PUZ6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732212.1">
        <property type="nucleotide sequence ID" value="XM_001732160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUZ6"/>
    <dbReference type="FunCoup" id="A8PUZ6">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUZ6"/>
    <dbReference type="GeneID" id="5856518"/>
    <dbReference type="KEGG" id="mgl:MGL_0805"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0805"/>
    <dbReference type="InParanoid" id="A8PUZ6"/>
    <dbReference type="OMA" id="VKWSVKA"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="398" mass="44006" checksum="DF39A2070955C49E" modified="2008-01-15" version="1">MDLGTIPGGNGGYELHQKLRTKTVRLMRKNKHNEAVETLHSGAIQLLDMNEEGSACDLAEYLLEVYMQAHVPMDNTSRERINSILEKTKSPMWRRKTVMAANKWAISATQNPLGDEKLRLFLAELLARDKQFYEAETHFIAACALNKDNASKFAHMLLEWNSSYAETLTESDSDQPPKDSVERVLSGTFALRGWVPLLLVHAPESARAFIQDYVQNAIKLHPALLLPVKPNPREYRSPAKVSTYSSEIFMTASPSLNFSQNAVALICDVKSKSGSVPNEMKSAWQMLLRQFVQEGGLAGMDSIVDVCVLSLFNSNIKQLLSQISGIYFGLSPPRRQTDMLSSMFSSMMGGGQSSSDEQSLSIKQLARPAVPESKKAAPAPPSAPPANEADQLVDEEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVB4</accession>
    <name>A8PVB4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731563.1">
        <property type="nucleotide sequence ID" value="XM_001731511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVB4"/>
    <dbReference type="STRING" id="425265.A8PVB4"/>
    <dbReference type="GeneID" id="5855860"/>
    <dbReference type="KEGG" id="mgl:MGL_0831"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0831"/>
    <dbReference type="InParanoid" id="A8PVB4"/>
    <dbReference type="OMA" id="WSYPPSA"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="246"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="398" mass="43766" checksum="971E3027792C45BD" modified="2008-01-15" version="1">MASTLRNGMRFAVYGVPMNLLARSLENTPQPITLPYLLAHGGQPGKAPTTDELLRSAKYTQQELPVRLARRVRQFYSLPFIIGTNPYIQEVARLYASSFQQLAEFSPVHTLEDNDRFAQKLRLLVEEHADLVPTLARGFMECKKYMDSVRISKFLDAALHSRIGIRIIAEQHLALSEAARKSRDGADVSSLSKSPTSVGIIDTQMSPVYVIRSSGEYVRALCEATYDMAPEIKFEGDLEARTVGIPVHLDYVMTELLKNSFRATTETFLTRHPGGSAEDMPPITVTLASAQGHITVRIRDEGGGIPPENMSQIFSYAFTSVQPQDTNESMAGDDSDVTGSALSSSMGTLAGLGYGLPLSRLYLGYFGESSLDIMSLYGYGCDTFVKLSKHIGESKVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVD1</accession>
    <name>A8PVD1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 1</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0836</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731568.1">
        <property type="nucleotide sequence ID" value="XM_001731516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVD1"/>
    <dbReference type="FunCoup" id="A8PVD1">
        <property type="interactions" value="736"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVD1"/>
    <dbReference type="GeneID" id="5855865"/>
    <dbReference type="KEGG" id="mgl:MGL_0836"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0836"/>
    <dbReference type="InParanoid" id="A8PVD1"/>
    <dbReference type="OMA" id="THLRGQF"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="196" mass="21924" checksum="6EAC6C4EA3D2E884" modified="2008-01-15" version="1">MEGARLRRIMREIAACEKESDDEIFVSMIDESPFHLIGSFPGPIHSPFEHGLFKVDIVVPEGYPFHPLQMRFITKVYHPNVSSQSGAICLDILKDQWSPVYTLKTTLMSLRSLLCSPEPNDPQDAEVAKHYTTDFHGYEKTARYWTETYASRDPASTSAGDEAQLAGLDTSQVDKFCNMALGGSGAQRVIIFITTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVF2</accession>
    <name>A8PVF2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0845</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731577.1">
        <property type="nucleotide sequence ID" value="XM_001731525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVF2"/>
    <dbReference type="FunCoup" id="A8PVF2">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVF2"/>
    <dbReference type="GeneID" id="5855883"/>
    <dbReference type="KEGG" id="mgl:MGL_0845"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0845"/>
    <dbReference type="InParanoid" id="A8PVF2"/>
    <dbReference type="OMA" id="YMEAWIG"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="312" mass="33576" checksum="321663EE798E7035" modified="2008-01-15" version="1">MESSVFEAQSLFYQSAYSGCIEFAQTHAPNGITDNTSLILLVYAARAALAMGDIAGARQLLGDDSEQPVAMSVLLLADFMEMKRSGDDAGSEDVIQQLIMLLDVVEPGELAAEIVRYQVGLALHENGDTKNALETLGVIGAGGSTELECIALGVHILLEIQRVDLAEKEYLAARKQNDDSILVQYMEAWIGLVRGGRATQQAYYVYDEMSQNTMIAHTRNMVPSLVGKAVAQAAQNDVPGATNTLNEALALDPQHTLALANQGVVQSLASDVTVPEAESTTNMYAKTEPASALVSFWDTKRYELEQAVAAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVF8</accession>
    <name>A8PVF8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731583.1">
        <property type="nucleotide sequence ID" value="XM_001731531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVF8"/>
    <dbReference type="STRING" id="425265.A8PVF8"/>
    <dbReference type="GeneID" id="5855889"/>
    <dbReference type="KEGG" id="mgl:MGL_0851"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0851"/>
    <dbReference type="InParanoid" id="A8PVF8"/>
    <dbReference type="OMA" id="KWTHAKA"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07119">
        <property type="entry name" value="ALDH_BADH-GbsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43860">
        <property type="entry name" value="BETAINE ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43860:SF2">
        <property type="entry name" value="BETAINE ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="519" mass="56748" checksum="5BF929ABFC8B22BF" modified="2008-01-15" version="1">MSSTLIDTPTLFIDGKWCASSERKTRATYNPYDASVIMHVDEATADDAKRAVTSAKTFFNTSDWPHKTYEERCALLDRMADTLQQHKAELARIETIDTGKTLGESEIDIDDVTQVFRFYAKEAIKLAQDKQVTGPLIPESVKSRIVHEPVGVCVLITPWNYPILQLCWKLAPALATGNVVIIKPSEVTPLSSVYLVKLLLEAGFPPHSVQILTASGASVGPVLTESADVDLVSFTGGLSTGRSIIRSCAETVKRCTVELGGKNPNVVFADCDLDWAIDNVLTAVFVHSGQVCSAGARLIVEESIADKLVDGVVKRAQNIVMGNGLDASSETGPLVSAEHLAKVESYVQLAREEGAVIRCGGRRPDPKTFPHLAKGYFFLPTVIDKCNRTMRIVQEESFGPILTVERFADGDERTAIMLANDTKYGLAGGVQSKDQARAERVARRLRHGTVWTNTYGVYTAQSEWGGYGMSGNGRELGSKGLDEYVEVKHIWSETKPAKMNWFKGSEPNDSEPQNSSARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVH3</accession>
    <name>A8PVH3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0866</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731598.1">
        <property type="nucleotide sequence ID" value="XM_001731546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVH3"/>
    <dbReference type="STRING" id="425265.A8PVH3"/>
    <dbReference type="GeneID" id="5855904"/>
    <dbReference type="KEGG" id="mgl:MGL_0866"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0866"/>
    <dbReference type="InParanoid" id="A8PVH3"/>
    <dbReference type="OMA" id="YEESTCG"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005122026" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="94"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="312" mass="34493" checksum="9742590A5D4C95A7" modified="2008-01-15" version="1">MRCGCMGALALLACVASFVVAQPLVQQPYTSPSFIHTVDDNLKHVRALSSWDKRVLERVLSQKWLQGKVESLARRLTANTNVRAFQHSWPQSSIILHIKGTNSTLTRERGITILGAHQDSVNFLPVFAAPGADDDGSGTVTLLEILRALGKAGWAPESDVEFHWYSAEEGGLLGSQAVTDEYIRQGVRVNAVLQMDMTAFVKEGTRERIGLADDFVSPSLTSCIERIASHYLHIPVARTLLEYGASDHASWTRVGQPSAFVIEAPFEDCNLQRIHTSRDIYDASGFSFPHLLQFVRLGMAYLVELADWVPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVJ2</accession>
    <name>A8PVJ2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731617.1">
        <property type="nucleotide sequence ID" value="XM_001731565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVJ2"/>
    <dbReference type="STRING" id="425265.A8PVJ2"/>
    <dbReference type="GeneID" id="5855923"/>
    <dbReference type="KEGG" id="mgl:MGL_0885"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0885"/>
    <dbReference type="InParanoid" id="A8PVJ2"/>
    <dbReference type="OMA" id="TRFDDSH"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="194" mass="21723" checksum="594BFF3AAE7E2CD5" modified="2008-01-15" version="1">MGSSYAHTVSDPTDMLATLQNQMEAVKNSVHLAFDKSMDKYLAEYETLDTQARASDPDTPLKYRLTAAKMLVSAAYVYLDTLWMYLKTQGVDPTTHPVHSELERVHSYFAKLKGVSSNTKEKTSQKIDVDAAKRMVHAAASLGKHTRFDEEKSHPPVQQPPSQNDVHEEPVQSAPSKKKKKLLSRQAKPSKKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVN0</accession>
    <name>A8PVN0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0912</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731644.1">
        <property type="nucleotide sequence ID" value="XM_001731592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVN0"/>
    <dbReference type="FunCoup" id="A8PVN0">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="GeneID" id="5855950"/>
    <dbReference type="KEGG" id="mgl:MGL_0912"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0912"/>
    <dbReference type="InParanoid" id="A8PVN0"/>
    <dbReference type="OMA" id="NWACVAL"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727968" description="DUF221-domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="678"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="709"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="35"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="220"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="426"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="810"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="885" mass="100811" checksum="76CADDDF4220C548" modified="2008-01-15" version="1">MIKQRNALILILSCLALPVLAAEDDEMRDSSTSSIISAIVYALILAGIFMVVFLYLRPRYPAIYQPKTYRALPASRNTQPLPKGTFNWIPSFLSVPDHEILRINGLDAYSFIWFIVLMLRIFVPIWILSWIVLMPLYAADLPVNSGSDPVGRGKGFNMFTFGNVINENNQQQKRSAGVLILHYIFMAWFIFNIHDVMTHFIKLRKEFLTSPDHRNTNQAKTFLVTSVPNQYLSETKIKQLYENLPGGIKRVWINRNLKELPKLVENRDKLANKLEGAVSKLIATAAKKVKKGKVEAVALPEGSEPSLDVADRYVPEKKRPKHRLGKIPCIGEKVDTINYSREELPRMNREIEDIRQNVINDYETYPPESSAFVLCNTMQGAYTGASFRPVENKSQMDKSYVEVHPDDIVWENMSFNPYERKLRTCACWGVTWLTVIFWAIPVALVSLFSNVDYMSEKIGFLGWIKQIPSVPLGIIKGVLPTTALAILNSLLPPWLRFHARMSGVPTRNLIELSLMTRFFIFMIVQNFIILTVLAGIQQNLDAFWDDVKEPKKFVQDISSAIPRASSFYLSYMALIGLSASAGIFSQLIPLLLYYVKIRFLSSTPRKLWHLRNDFNSPPWGTLYPSTLFMTVIAFGYMVLQPVTNGFACVAFFLLYLAYRYSYLYVFDCKPVKETAGQFFVKAIHFTFISAYVSIFVVALMYFFKTGDNASFAAMGVLTIVLGLLVAAYHIYMYVWYEREMQKIPELLASKTNELSSNPLNDGAGALVLPEKDEYYANAEQEKQLIPQGPRPLGPESKALALQMEDPGLEEEKQQMREIETMNAFFNPARLKDQMILWYPNDNYGIGRSQMLADYSAGYQSSVDNAFINEKYKIDENADVPPGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVP0</accession>
    <name>A8PVP0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731651.1">
        <property type="nucleotide sequence ID" value="XM_001731599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVP0"/>
    <dbReference type="STRING" id="425265.A8PVP0"/>
    <dbReference type="GeneID" id="5855957"/>
    <dbReference type="KEGG" id="mgl:MGL_0919"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0919"/>
    <dbReference type="InParanoid" id="A8PVP0"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="157" mass="17936" checksum="3F2F3382E741BC74" modified="2008-01-15" version="1">MGNWRTNNFYYIDMNRLDKVFTAISNVVEPALKYKLKVAWELTVMRHVSAKVFASLLFAWVPLVLWKILATPMIKDSVPAIYFKLKHLFVCPRKGPDAEATALSSQISTKALEKDFSQLRQRKSTGTVSNEFAQTTPRMSPKATNHLEEQFCRGPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW08</accession>
    <name>A8PW08_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731732.1">
        <property type="nucleotide sequence ID" value="XM_001731680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW08"/>
    <dbReference type="FunCoup" id="A8PW08">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW08"/>
    <dbReference type="GeneID" id="5856037"/>
    <dbReference type="KEGG" id="mgl:MGL_1000"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1000"/>
    <dbReference type="InParanoid" id="A8PW08"/>
    <dbReference type="OMA" id="CNHKLEP"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="341" mass="37673" checksum="F41B6D63B6374315" modified="2008-01-15" version="1">MSAHFADAPVRVFDNVDSYRAWRQTILRTHASVGFVPTMGALHEGHLRLVDRSLCDNDYTIVSIFVNPAQFAPHEDLSVYPRTTRSDIEQLGIREGALQKHGRLMVLLPQVQDMYPNGITQNVDDQIGAFIEVKGLSHQMEGSTRPTFFRGVATVVTKLFNIVMPDRAYFGQKDIQQAIVIRRLVDDLLFMFPHGSRNVHVLPTVRDPQDQLALSSRNKYLDAQGRHVAPVLYAALKKGQGVWDDLATKNVAPADRLSPTLEAVQTHLSAHAKLADGDHEARAELDYVALNHPSTLDPLTPANASAEGAILSGAIYVYNRATDPSPAARLIDNVLLGFTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW46</accession>
    <name>A8PW46_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hypothetical polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1024</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731756.1">
        <property type="nucleotide sequence ID" value="XM_001731704.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW46"/>
    <dbReference type="GeneID" id="5856061"/>
    <dbReference type="KEGG" id="mgl:MGL_1024"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1024"/>
    <dbReference type="InParanoid" id="A8PW46"/>
    <dbReference type="OMA" id="LRQNSVM"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="11"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="923"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2227"/>
            <end position="2305"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="923"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2303"/>
            <end position="2339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2315"/>
            <end position="2334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="958"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="2737" mass="299942" checksum="1F65D7ADFA752CFB" modified="2008-01-15" version="1">MTSQSVDQERPESLSVVGIGLRLPGARDKKEYFELLKEARCAIGRVPSNRWNPDAMTQLGGVPGMVVTDQGGFVDPHTEIDSLEFGISPAEARQLDPHQLMLVEVVFQALEDSGVHYRGTNTGVFVTGSPDVHNLGNDMWDMGPYSATGAAFSMQANRLSYLFDLRGPSVYLDTACSSSITCLHLARAAILRGDCDMAVVAAVNLILAPHASLSFSTLGTLSPSGLCHTFDASADGYSRGEGCTVIILQRTNEAVRMGSHIYSEITGTAINANGKGKSITLPDGPQQKAATYAAYRDAKREPHEAAYVECHGTGTPVGDPIEANAVGEVFTPGREKDDYLRIGSAKTNVGHLEPAAGLVGLIKNCYTLDMGLMLPHLHFKNPSPRIRWDDFLIKVQTETEPLPPNKLSKDGKFIVSLSSFGFGGANSHTVMERVPNDSLTRDVVPLSPQDPMLIAVGALSNRAVSSLSTSVQEAWAETKDPLSASLLARTMTERARGHPNLAFAVGSLNDSLSFSDTVVTSTPDLNPIKAFVFCGQGPQHEDMGRHLYMRFAAFRNSVNASFEMVAKFHRKNFQEEYGLFNPEAEGKVAKTETGDWKVECIVIAITIFQIALFDLWVDLGVKPDVVMGHSVGEIAAMYASGALSHEKAIRTAIARSNALTLLDTVDGQMAALGLSRQEAQKLIERIMKDHQEETGLWVSASNSTNACAVSGKTNLLNAVVKDCEANGVFARLLRVGGPYHSPMVAPCGEPFLKEVYPVIDADVNIPTTRFISTVDGRMHEVGEKLDAQYCWKNVSQPVLFRESIEALNEYRKSQDRGLLIIEVAPHTVLGSYMDEILRAADAERTTIVASARRMNVKKGETREMQVEITQFLTAVGTALQAGVRDFVLYKLYGDQFIDRPMGVNSTLSNLPAYLFLPLKRVPHETSFPEHLRCRPPMPPLSAKAFRINAQTHSWTKGHKIRGTIVFPGAGYAEAALENGARTITHMRILRAFVLEEDGAPKYAQFKLTGVNNGWEFRSSAKGSVDDGGIVFDQLHASGHMSPESTPIGPSNISELFGKNWIEDFDIVMDGETFYQRLRPNGSMHTGAFGLINEVRGSTKREDDYLAFVDVPSDLWSSRETYGMVFHPGLLDSAFLCTWIPALPFDGQKLGVDAFLPNLLDILSVRATAEEIRQVKRIVLHVQTLISNDTDIKHNVLMFDRDTGKTLAFLKGLECKRIKDTARNREGYSESWEPRAFDADPSLMESCAMETSLTSKFLDNMAANDDSGVVAKALERDSVIGSELRDEFFDLPGVSLELGEGLNRLAEKLIESSLRTPRRVFRVIEVYARHRKISMQPLVTAMQRLGIYVDVVRLNVANALRGTDAFLTGPYDVKQAIEDSERTIPASFEIAVVCDVLNETTDIKSTMQAVENLLVPGALAMYVEVKASTPVGKLFYKDAPSSLAALDLQPFGVSPIFSLGYMRRDENAWPAIPTIPTKEVGDPTSMTRALADDELLFYHQFGNEHLIPQAVREHFKSDTPVGKLWIITDDTVEGACAMGIAGTVTNEFMTIKGIYVAVDPSMTRAQRDGLIDMLHEREEEGSLEMFNVIRNGRLYGRRLVKLPDMHPTEFTGHDWVLELIEGETPSVHALAAHAHFPPNPSDHDIIVQTDAVALNFKNVLSAIGLLPAEDCLSEFSGIVREVGAAVTRVRVGDRVMGTSGGVREGIVATASEYAVTKVPENMTPLQAAAFPIAYGTVWHGLVQLAQIRAGETILIHAAAGGVGLCAIQIAKRHGLEVFCTVSSKEKRDYIHNHLGVPYENMANSRSVAEWTQGSRDWLAKRGKQGFDVVLNSLQGAALQAGIDVLAHLGRFVDISKRDHLAGNPMSMSGFLKAINYIAVELGLLGRYAPTRMASLLDEIADVHRAAPFKCIYNHAFNGVEGLLRSYELMESGKHIGKIVTDLSECCVPTKKQLLWNPNKTYDPRKSYVLVGGCGGLGPRLVQFLINYGARNIVVTGRRGQISRSDRLALERLVRDPAFPHVTIKIMAADALKPEAMKDVMATANSLGPIGGVFLMSVVLRDDQFMNMDKEKFETVMNSKVGALKVLERTINVNNLDFLFLFSSTAALFFNPGQTNYNAAQAYFNRYAREHKNVVSYAVPAISDIGVYAEMRARSNNAALKIMDALACTSRELCEYIAQALGRCMMGGSNHEGYFIQTMDWEIMQEISPANAWSISHLIEHHDDEGDNDEDEEEGADPVGVLLGKLLNVDIATVDDTMFLSTLGLDSLSASKLSAILLAEYGTTVTQLQLLGPVSVDSLRQIVAESQGDGKGEEEAAAAPTKKSKPSTPSSAAVKPQDGKANVAASNKIDVSALKNFDYASEPEKLDDLPPSLLGLVPFDAKVMQPESELRILVTGATGFMGATVLEAVLESFPRAQVTALVRGSVEGGMDRIKDVATKRHLKTLKHMDRVKTVLGDASKPKLGISNAEYARLASELDLIVHAGGKADHLMGYQTIVGDNVISTREVLRLASEQKVKAVLNIGSTNMWLTFSDKKVNDEVVNEDVDLDELRTGLFNGYSQSKWVAEQLCERAKKRGVPVVTVRPGALGGNARSTYVPNEDSFLWRMYNGCRQLGCAPDSQSSAFTETPADWFSDILGKLMSTPRTWESGYNAFHIRNDRLVRMDNVPTRPGETKPKIVPHDDWVDAVYKEASNPHSTNPLTPLRHFIAKGQLAHLPHFDQTRTREMLGDQWVECPPYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW78</accession>
    <name>A8PW78_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731774.1">
        <property type="nucleotide sequence ID" value="XM_001731722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW78"/>
    <dbReference type="STRING" id="425265.A8PW78"/>
    <dbReference type="GeneID" id="5856079"/>
    <dbReference type="KEGG" id="mgl:MGL_1042"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1042"/>
    <dbReference type="InParanoid" id="A8PW78"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="442" mass="48270" checksum="DE0CD59911F2A1A7" modified="2008-01-15" version="1">MTEGAARLSRDKCDIAINWAGGLHHAKKGEASGFCYINDIVLGILELLRYHARVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKYGEFFPGTGELRDIGCGKGKHYACNVPLRDGITDESYQSVFRPVIQRIMEIYQPSAVVLQCGSDSLAGDKLGCFNLSMRGHASCVEFVKSFGLPLLLLGGGGYTMRNVSRAWAYETGLASGYQLSSELPVNEYYEYFGPEYRLDVVPSNMENLNTREYLEKVKEQVFENLRHIAPAPSVQGHVEPRLAHDMALDDMGAHDDAANPDIRTTQDQKDRRIQRETELDDSDDEGEGDRRDRRSWKDENDMDIVDEPATTSATSATLPCGPSTGMPPAPVTLQQPSTSKMESEPAQMSPVMSGSTATAAPDQAPSVSHASSPDSSVQGIAAPSASTRGAYPTPDMTNDASAQAVDGKRSPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWC1</accession>
    <name>A8PWC1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731798.1">
        <property type="nucleotide sequence ID" value="XM_001731746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWC1"/>
    <dbReference type="STRING" id="425265.A8PWC1"/>
    <dbReference type="GeneID" id="5856103"/>
    <dbReference type="KEGG" id="mgl:MGL_1066"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1066"/>
    <dbReference type="InParanoid" id="A8PWC1"/>
    <dbReference type="OMA" id="KECMCAT"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="765" mass="84544" checksum="3BB360C6B645C0E8" modified="2008-01-15" version="1">MQAYLPDAGFEYVVTHRYRTARLQRLQFLNTMSDEARFSAHLIPGRSDLCVMAVRSFQPDDIITYCTAALKDLTHQEDQALREEAAEAREADLRDGHLRPQRDFSIIRSSRRKCSQLLLGPARFINHDCRPNAEFRRSGHILTIRCIRPIQCNEEITTYYGDNYFEWQNKECMCATCERLGQGFYAQLRPALPKPAADLETRRDTNQCQDVPHHEDARRMLRSASARTAAAKESVSTSAQTIAFQVDPDASGPVCECATCHAQFRAPEKWWTPDECARCERHYKLFKCDWPHRKPRENPAEQTSSSRAPKRSSKLVDKPPRLPKKARHTSNAQLSSSPVKLSPVHEKPLESSSESDSLSTASSPSSRHDLSTDQDQAHRIPTPPAPRILGHGASTDVLAAYWGAPEGERKRRRRPTNMSLTLLSNRAVLDESKQPLSSSHSSRKTRSQDSSPYDKRTAHVPPVSRSKCKSSLPSSLQTAASPNGGFESKHMPNVPLQCSRNMMECSEAEAQVQDMRTAAGQGPECKSVSVHEHESKPLVKQRANAGLERASGSESNSASASKCTLECNDVTKSQSKSSVHQHNTTSDNASDPGQRKSSPKIATQGPERTSVLNLALFWSGGVEGRTRRQARQAHLCRRTPPPSPGSPQARTDAPMSSASTPYQIKQESCPATPEPPAPCLQRSPEETLSYPSTHAPSLIHSNCQPTVVPPGAPVRQPVRRNLRWGSGKTSTSRPPTQAAPLRVAWPSLMKAEPSGPITSASQHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWL0</accession>
    <name>A8PWL0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Poly(A) polymerase</fullName>
            <ecNumber evidence="13">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_1137</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="13"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731869.1">
        <property type="nucleotide sequence ID" value="XM_001731817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWL0"/>
    <dbReference type="FunCoup" id="A8PWL0">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWL0"/>
    <dbReference type="GeneID" id="5856174"/>
    <dbReference type="KEGG" id="mgl:MGL_1137"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1137"/>
    <dbReference type="InParanoid" id="A8PWL0"/>
    <dbReference type="OMA" id="PAYPAMC"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000003">
        <property type="entry name" value="Poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="18">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="17">
        <location>
            <begin position="207"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="16">
        <location>
            <begin position="354"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP44655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="527" mass="59924" checksum="2CFBDEBF58D34E09" modified="2008-01-15" version="1">MSTGVKMWGVTPPISMNGPTEKDLEVTNALEAELRANNVFESPEEAKLREVVLGRVDALVKEFVYRASIKHGLSESAARASGGKIFTFGSYRLGVHGPGSDIDTLCVAPKHVQREDFFEIFEALLQARDDVTEVTSVPEAYVPLIKTKFMGISIDFLFSRIALPRIDDSLELRDDNLLKNLDERDVRSLGGSRVTDEILHLVPNVYVFRLALRCIKLWASRRAIYSNVLGFLGGVAWAMLVARICQLYPNEVAGAIVSRFFIILLQWKWPQPVLLKQIEDGPLPIRVWNPRLYPTDRLHRMPIITPAYPSMCATHNVTQSTQMVMTEEFRRGSEVVDRIFRGKTSWNELFEKNDFFHKYKYYLQVIASSGSADLQLKWQGTVESRLRQLIMKLELVPALLCAHPFVKGFNHECVCYTDEEVRQVATGDVPADVASRAKMQDLPEGEAAKEKDESVQVHDATENGRRTVYTTTFYIGLKVEPRQPHDPSVRRFDISYPTLDFTQRVKQWDQYDESAMGIVVRYVKGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWQ2</accession>
    <name>A8PWQ2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731911.1">
        <property type="nucleotide sequence ID" value="XM_001731859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWQ2"/>
    <dbReference type="FunCoup" id="A8PWQ2">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWQ2"/>
    <dbReference type="GeneID" id="5856216"/>
    <dbReference type="KEGG" id="mgl:MGL_1179"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1179"/>
    <dbReference type="InParanoid" id="A8PWQ2"/>
    <dbReference type="OMA" id="RDHPWRY"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="289" mass="31560" checksum="4FB249B7808D5A19" modified="2008-01-15" version="1">MREGTWNKVAKGCFELRGKLLGIIGYGHIGSQLSVLAESMGMRVIYYDVVPLMPLGSARQADSLEELLKEADFVSVHVPELPETRGMIGERELSMMKPGAFLINNARGSVVQIPALVDALSSQRLGGCALDVYPREPAKNGVGNFNDDLNSWASKLQAQSNVIMTPHIGGSTEEAQRMIGIEVGNALCRYINYGGSVGAVNFPEVNLRPITEQEVRSIRICYVHHNQPGALLAVNEIIGLHNVDKQHSDSQKDLAYLLADISDVSESDIQDIYTRLSKTPACILTRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWQ7</accession>
    <name>A8PWQ7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_1184</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731916.1">
        <property type="nucleotide sequence ID" value="XM_001731864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWQ7"/>
    <dbReference type="FunCoup" id="A8PWQ7">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWQ7"/>
    <dbReference type="GeneID" id="5856221"/>
    <dbReference type="KEGG" id="mgl:MGL_1184"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1184"/>
    <dbReference type="InParanoid" id="A8PWQ7"/>
    <dbReference type="OMA" id="IQHCKRA"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1067"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="66"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP44702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1231" mass="136099" checksum="F2146B5603E5DB53" modified="2008-01-15" version="1">MQDEGNVTDEKDAGFFAQFKGFFAGEKQKAAKAAQLQAEMEMRLWKDPGPFRFRPGELCALIDPEDFSKLEQMGGIDGLMQGLQTTSEKGITSSEFGTDNDADKADTIKQRASVYGTNILPKRESKSLLMLMWLALQDKILILLIVAAIVSLALGLYTKFSGRNEPVPCPDPPPGQDMCEGPSVDWVEGVAILIAVIIVDLVGSLNDWQKERQFRVLDAKKDSRAITVLRDGQKRLIDIHDAVVGDVVSIEPGEVVAFDGVVLRSHNIKCDESSVTGESDMIQKVSYEEYLSERSNGTLKHKSVFMISGSKVLEGVGDFVITAVGSLSMHGKLMMSLREEPENTPLQKKLNHLAEMIAKFGSAAGILMFIALMIRFFVRLGRDSDVDSNEYGQLFIDILIISVTVVVVAVPEGLPLAVTLALAFATRRMSNRNLLVRILGSCETMANATCICTDKTGTLTQNNMNVVAGLIGDGMPFYDEVKLEVENAQVNSDGVNISELTLELPEAVRNMLIQLICIDSTAFIPKESDNSDHFVSSHEKKPFWARWMSRPAPSNALLKAAKGEVNFVGSKTETALLNLVRRLDWADYEEVRAAADILQVFPFSSKRKAMAVVVRTEFGARLYVKGASEMILNLATSVVSMSSSKLSSVIQSKPLDDNERQHQLSNIEGYAKQSLRTLGLAYRDFSAWPPPGIRLNTADEVDFDDVVKSLCFLAIAAIEDPLRRGVTDAVRSCGKAGVNVKMCTGDNIMTACSIGRQCGIYHEGGVAIEGPVFRQLSHADLVELVPHLHILARSSPEDKKVLTNTLKDLGQVVAVTGDGTNDGPALKSANVGFSMGIAGSEVAKEASDIILLDDNFSSIVNAIMWGRCVNDAVRKFLQFQLTVNIVAVIVTYVSFRFHRANQNSVLTAVQLLWLNLIMDTLAALALATDPADPRSLERKPDRSTAPLITPEMWKQIAVQSIYQVILVLVLYYRGMDILNEHDKSHPQELINKLEIDTLIFNVFVWCQLFNQVNSRRLDRHWNIFHNFHKNLWFMCIMLIEIGCQVLIIFVGGAAFSVKRMNGRDWGISIVAGFVSWPLGLITRWLPTKPLEDLLIKLKLMHDPNELPYNSSRSSEESLMEWNEPAIGQIAKQIGSFSRIRGGRLRASNLVLKSNAKLMRENDVHPQEIMAMVPALIGTSVGGMWKLSKQGSYGNMDQSQAQVSIKTLYRQGKIVFHPNTPSDHPYLLSLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWS2</accession>
    <name>A8PWS2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_1199</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731931.1">
        <property type="nucleotide sequence ID" value="XM_001731879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWS2"/>
    <dbReference type="FunCoup" id="A8PWS2">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWS2"/>
    <dbReference type="GeneID" id="5856236"/>
    <dbReference type="KEGG" id="mgl:MGL_1199"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1199"/>
    <dbReference type="InParanoid" id="A8PWS2"/>
    <dbReference type="OMA" id="NSADYRP"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000002">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="185"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="14">
        <location>
            <begin position="1081"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="669"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1061"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="669"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1131" mass="121753" checksum="5B0EA4A7E0E14054" modified="2008-01-15" version="1">MQHPSEHTFVQRDAMPGSAEGPGTLTSSQALPSLSSMQQPSEAANKNDLGYLSPQAAHSLTSPPAPKRTGSPLRPVTQTHTATHFHDNSGLVDPEALQAFSRMNLGSFGPTAPAATRTQHAFPTAAAAPHPPAQVTNHTHAAQYAAPAHQTVPKAKSSAGAAATRTSHAVTPTSDESFRWTLGDYMLGRTIGAGSMGKVKYGHCKADGQKVAVKIVPRNTSVNALKQSRGKSKHTGQPLTEAELESAFARASTKDTSKEVRIVREGSLQMLLLHPYICRMREMITHPNHHYMVFEHINGGQMLDYIIAHGRLRERSARTFARQIGSALQYCHANNVVHRDLKIENILISKSGNIKIIDFGLSNMYTPQGHLNTFCGSLYFAAPELLNARVYTGPEVDIWSFGVVLYVLVCGKVPFDDQSMPVLHARIKRGMVEYPGWLSPDCKHLLSRMIEVNPLQRATLSEIMSHPWMMKDHHAPEPNYLPKRTPLSASDLDPAVIERMTGFEFGSPQDIHQQLLSVLRSESYLDAVARHEHGHTQHLEAVPPNSGASSVDAPRGNRISRQITAGLNFYHRHMFKSSDTPSSSSATVEGPPGIKGPIHPAYGFHPLISVYFLVKEKMERERFGGSEVLNSSDLLLPQSGTVGHSRHAPPQDVPESAAIEHLDQVSLSASMPTSATAVPAPSSAASPPPHPSSSYSGMAHPASSAIGRLVADIPSPTVRPPERSHVSSRTVGAAASVPFPPSPLPPTAALMAGRDSTTPVFESRQKSQPMAVMMGPPRPLAHADELESSLRSGMKSPTGLTDNYVARTSPISPVFERKAIPQRSMSMNHARHARHVEQGRAGRDGRAYAVQLSDAARPLPTLDAIQSEAGLGLFTGEAPEVSNSMASDSVTGAGANLTRRFGTMSARPSHNTSNVIVPPPDLFSGQTHAYAVETGAANTPDMHTSLDEATSKPVFLKGLFSVQTTSRRPRAIIRRDLIRVLEQFGVHYSETKSGFECSYQAPLIETDSLGSPKRSTSHLSSAATSSPIAGAAFTSMQQSHSPVATGVGDIGIDAATPSEGVLSTPAFDSTPTKSGASKPRLSEDEVEVVFEICIVKVPLLLGMNGLQFRRVSGNPWQYQTLAKRILNELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX26</accession>
    <name>A8PX26_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732034.1">
        <property type="nucleotide sequence ID" value="XM_001731982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX26"/>
    <dbReference type="FunCoup" id="A8PX26">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX26"/>
    <dbReference type="GeneID" id="5856339"/>
    <dbReference type="KEGG" id="mgl:MGL_1302"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1302"/>
    <dbReference type="InParanoid" id="A8PX26"/>
    <dbReference type="OMA" id="REQRAYM"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="204"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32905" checksum="A686A0ED29381B86" modified="2008-01-15" version="1">MENSDLQNEIAAATNHLIKLNALDELRLEDPEFSRHKAEEAPDANRYLNVIPYDHALLPGAYQNASLIPPYSGNRNSASCVASQAPLATTLSQFFEQLHAQKSKVIVNLTALEENGIVKSERYWPLDKETPFISPDGQWTVFLMSDLPAKDAFDKTQYAEAASLLDLRVRRLKLLSIMGKERKEHEITQLHFIGWPDHGALAPLHLLALIQAVRAVQPSAVPTPIWVHCSAGIGRSGTLIGTLFAQEEPILSSTNQSSIETTANITAHMRKFRPGSVQSVGQFLAMAHAIGSLRSEKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXF1</accession>
    <name>A8PXF1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731244.1">
        <property type="nucleotide sequence ID" value="XM_001731192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXF1"/>
    <dbReference type="STRING" id="425265.A8PXF1"/>
    <dbReference type="GeneID" id="5855551"/>
    <dbReference type="KEGG" id="mgl:MGL_1427"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1427"/>
    <dbReference type="InParanoid" id="A8PXF1"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF4">
        <property type="entry name" value="PROTEIN CBR-NRD-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="466"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="564" mass="61115" checksum="85C970DA1F5B7502" modified="2008-01-15" version="1">MRRSQALNCGDVFKVDTQESGLVSMTSIAPSLPPNHRDTCFSNSLSSDEKNIWDLCDSSFFDNACRFEARDPWASAGASKIAVGSLPKAFDTSWLSDLMSQVKLPSAPPSTDGEVGHESDSSSPIPQALWQQLASPFQSPKATTSKINPAKDWFARDAVNITKAPTFSPYNYNGDALGIYPRHPASTGILKSSYSPHVLSSVIVRGLEVHVTEEDLVLHFTRPPSWPDDHPMKRMHTHVQSMAGSTGQLPTQPAPFKVYSARIIHESPHRIGRVFGFVRLISKEECDRALVELQHTHLIPKRPPHFPLRLCLGLAAAPPATEYQRRGNAKAQKRWHESMFAYSERNRARSASTMSSPSKRPTDVFGSRNPARLASTPAPIRSESASSPSSRSTTASTSISASTSTSMSSSSMTSSTPNQAFSSEGVPTVLTFVSEFTKESDSKEQPHLASALTKAHASSALDPTNTTVFVGSLFSLATENTLRTLFAPYGPIQSINIPRGQDCGFVQFASKQDAARAIAEMQGFQIVGGGALRLSWGRSVGEKAAARAAIRAGLRWVEDSTIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXG6</accession>
    <name>A8PXG6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1442</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731259.1">
        <property type="nucleotide sequence ID" value="XM_001731207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXG6"/>
    <dbReference type="STRING" id="425265.A8PXG6"/>
    <dbReference type="GeneID" id="5855566"/>
    <dbReference type="KEGG" id="mgl:MGL_1442"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1442"/>
    <dbReference type="InParanoid" id="A8PXG6"/>
    <dbReference type="OMA" id="EVSNPWK"/>
    <dbReference type="OrthoDB" id="1920692at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP44045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="95" mass="10561" checksum="0F453C4D2499364F" modified="2008-01-15" version="1">MPVPFEAIIPMGIVVALFGVTGTGYNAVAHLANEGKPVRHNLDEWERMMMRRDQRLTGTRRGQSSICMNGTSNEQREAIAPEQFATNSGWSAERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXG8</accession>
    <name>A8PXG8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731260.1">
        <property type="nucleotide sequence ID" value="XM_001731208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXG8"/>
    <dbReference type="STRING" id="425265.A8PXG8"/>
    <dbReference type="GeneID" id="5855567"/>
    <dbReference type="KEGG" id="mgl:MGL_1443"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1443"/>
    <dbReference type="InParanoid" id="A8PXG8"/>
    <dbReference type="OMA" id="HERIPRM"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="3">
        <location>
            <begin position="179"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45525" checksum="68EA4B5DB33E33A8" modified="2008-01-15" version="1">MTTDSELATKPTAMDQQAPPAPGPDVRVVFVGAGQINFGSPEGPWNHSFRLEHKLGPRLKVIALIDPVTENAENVLKKKRESFVLSAYKDTAIFKDVPSYLASVTPETRPHVVWIGSPPAFRGSMHAGRDVERVLADSLPGIGLFLEKPVTTSSVEDVMQVSRYIEGKMSPLSVGYMLRYLKVSQKLKQIIAENKLQVMAVNCRFVIAYERLTKQWWWNKEQSLGPVIEQATHFCDLARYFGGEVELDSVVAHSLEHFEAPSKLSKLAFNEDETIPAEQRVPRVSSATWKYTSGAVGSLMHVIALHGRDFFTEIDVFADGYSLRLVDAYNAPTLYVRRPGDDHEEVYKYADDDPFFSEVSSMIDAVEDPSKSDEILCSFDDAAHTYAFTWAIRRACETQVDRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXP0</accession>
    <name>A8PXP0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731309.1">
        <property type="nucleotide sequence ID" value="XM_001731257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXP0"/>
    <dbReference type="GeneID" id="5855616"/>
    <dbReference type="KEGG" id="mgl:MGL_1492"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1492"/>
    <dbReference type="InParanoid" id="A8PXP0"/>
    <dbReference type="OMA" id="DTHELTC"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="728" mass="76144" checksum="53C2F52B6C562CE2" modified="2008-01-15" version="1">MHDSLDGSASPKRHSKDLFTTGSPALAWISAHGRTGSVSTTTSPASVPSASSPSGANARTPAIAQVSRGSSKSRSHDHAIPETHHLVSSMASDANAHSSTMTAPTISSLGLGLYIPPEQPPTSASSHAGKDVLSFDGVAHESGNDTALPLDNMSGGGMDEPNVSAVLNDVMHWHVSPVPPATSTSSSSISQSRHTLSQRPPAPSTVTSRVNVMTKPVTTSSSSQLLPSESQARVRIISTASQKAPRLVDPVPDDDDDAMPLPPMKAPPVITPAFTSLPTRRPPASRRTEPLHLPHASKPTTRAAVTADTPDVSAAAQAVNATPTAATADTVPEKTDITDAAAVESSGAHTAPGPTNASGVPPASRSAVPASKPTTHIAPSVRKSMEFESRRPPSRSNTPGSALGLYLDDEPALEQVSETEHDPVPDPPAKPVKELSGAQRGQLLDTTTPLDLMHHESDTENRDLFADNKRTETARHHDPHPHSVGTSELSMNAKARVNAHGNKRASEGAASAMGFTLPTAHDHEPMPMPNTRGSLEPGSMHKAVVHSVSTPRATLISDMARTPPQAERESNQPAGPHTHAPSHVELQPSSQRAEQPTPRASAASPATEAHRSLYQDSVVHAPAAQDPVRVSTHDRVETLHRPDAVLYSSDAHYQQDGAEANATDGERARDVTQSTEKAAAPALTTSPDGTAAAHSPRPVAGPALPSKTQPRHDRGAIRDSTLPWDARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXT1</accession>
    <name>A8PXT1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731335.1">
        <property type="nucleotide sequence ID" value="XM_001731283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXT1"/>
    <dbReference type="FunCoup" id="A8PXT1">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXT1"/>
    <dbReference type="GeneID" id="5855642"/>
    <dbReference type="KEGG" id="mgl:MGL_1518"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1518"/>
    <dbReference type="InParanoid" id="A8PXT1"/>
    <dbReference type="OMA" id="EFWIQIM"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="281" mass="31317" checksum="27630FBCCDDB668E" modified="2008-01-15" version="1">MDYQNRAGNKGAGIANASDAAIDRRERLRRLAMETIDISKDPYILRNHLGGLECRLCLTMHANEGSYLAHTQGKKHQTNLQRRAALGARTNDAQNRAASALLAPAPEMPKKTFVKIGRPGYRITKIREPILPVDMDGSDVDGAVPNTAASTAAGTSDDKSDSHKNIDAVAQQHARATSGRVGLVFEVSLPEIKEDVIPLHRFMSSFEQRKEAPNRAWQYLLVAAEPYETIAFKLQSREIDRSHTLTLPGVPVPEQRDEPCTWSHWDPFQKTYTIQVLFRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXV3</accession>
    <name>A8PXV3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731349.1">
        <property type="nucleotide sequence ID" value="XM_001731297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXV3"/>
    <dbReference type="FunCoup" id="A8PXV3">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXV3"/>
    <dbReference type="GeneID" id="5855656"/>
    <dbReference type="KEGG" id="mgl:MGL_1532"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1532"/>
    <dbReference type="InParanoid" id="A8PXV3"/>
    <dbReference type="OMA" id="CWARQTI"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000002">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="329"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="639" mass="72343" checksum="05312E7E6A1228BF" modified="2008-01-15" version="1">MKTYSQSLPTYPPAKSAMEAAENGLAFYRHLQSSDGHFAGEYGGPMFLLPGLVIGMYVTETPIPEPWRIEIARYLWHRRHPEDGGWGIHIEGHSTVFGTALNYVVLRLVGVPAEHPMMVQARGTLWKLGGAAGIPSWGKLWLAVLNVYDWEGLNPIPPELWVLPDFVPIHPWRWWVHTRMVYLPMGFLYGKRFTAPVTPLIESLRAELYPTAYKDIDWPAQRNHVASVDLYAPHTRVVNALFYVLGKYEHIHIPSLREAGMKRAYELIVKEDSNTSFQCLGPVNKMLNYIVRWIVDGPNSEAMERHREKLKDFAWMGAEGLMMTGTNGSQLWDTSFIAQAMCESGLSAKPANHEICRRILSWLDMCQIRENPRFHRTAYRFATKGAWPFSTREQGYTVSDCTAEGLKGVLMLQEASGASLGRPVSQRRLRDTVDLLLSMQNPGGGYASYETINGPSFTEWLNPAEVFGNIMVEYAYPECTTSVVSGLRMFQQYDDYRSAEIDAAVERAVKYILGAQRPDGSWYGSWAICFTYAAMFALESLKHAGYTYENSEPVRRACTFLLSKQREDGGWGESYKSCETHEYVQSDSQVVQTSWAIIGLLHAGYPEAKPIQRAVTLIMQRQLPDGSWAQEQIEGIFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY16</accession>
    <name>A8PY16_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731388.1">
        <property type="nucleotide sequence ID" value="XM_001731336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY16"/>
    <dbReference type="FunCoup" id="A8PY16">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="GeneID" id="5855695"/>
    <dbReference type="KEGG" id="mgl:MGL_1571"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1571"/>
    <dbReference type="InParanoid" id="A8PY16"/>
    <dbReference type="OMA" id="QWHNPSM"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="78"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="663" mass="70584" checksum="B38AFC32EC6ACAA8" modified="2008-01-15" version="1">MSHASPMHPACLVTPSKHAATSSRSPFQRYASDSALDHTHLVHDAMQSWSAHIETVMEETPLISLRTSHTRERKHTHTLLLLYSAIFLLALAASLDSMSFNLYLNYACSEFQALSSVGTVMIAQQLVRAISKPPLARLADAVGRISTLVSCIAMYAGGCAVMAAASSLRAFILGTMIHSLGATGVGVLHAIIMADTSSAQWRGFLIGLVNLPYVLNFALVGPLVDTTLRTGGWRLGLAMWVVVVPIAALPLLSLLVLGSRRASRRVPRRWLPQRAASRVVREMDLLGMLLLSCGLTLLLLPVSLEGPRAIFDAAHAHRVDVPTGAAFLVAFGVWETWTTSPLFPRSMLTNVCVSATCLIAALDFAGFYLSWTYLSPFVQILKNWDQGLTAYFVTTQNVTSTIAGMVVGSCMAYTRRLKRYLLFGFIIRLLGVLLMVHYRSVGHSALALLTCQVLQGIGGGALALTTQVAVQVAVEPSKIAAVIAFELLTTDLGAALGSTLASAVVQSVLPPALASRLPELSAPELEHIQGSLEAVLSHPPGTPMRTEITAAWVHVMKWLCVLSVVTQLPALGLSFFIPDMNLHEPKPIPPASPAPMVPAAPASSLPVRIAGAGAMDAALPASCATSAPPAPSCLQESTIPIRSSLPPWHAANDENAPGAMPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYA8</accession>
    <name>A8PYA8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731442.1">
        <property type="nucleotide sequence ID" value="XM_001731390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYA8"/>
    <dbReference type="FunCoup" id="A8PYA8">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYA8"/>
    <dbReference type="GeneID" id="5855749"/>
    <dbReference type="KEGG" id="mgl:MGL_1625"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1625"/>
    <dbReference type="InParanoid" id="A8PYA8"/>
    <dbReference type="OMA" id="FYQGPPF"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="460"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="487"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="533"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="606" mass="65097" checksum="2AC6287CC5134217" modified="2008-01-15" version="1">MSLQLVGTYAPNPTNVRARSTKLGASPQGDRILYAQGRTVVIRHIRDERATTLYAQHAQPVTVARMSPSGFYVASADITGKVRVWDIAGSEQMLKLEVQALAGRVHDLVWDGESKRILVVGDGREKYAHAFLFDTGSSVGELNGHSKAVNSVAVRSQRPFRAVTGADDCSVMFYTGVPFRYARTLSHHTRFVQDVAYAPNGTTFASAGADGRVFLYDGQTGNMQAELSVASTAHAGTVFAVSYSPDSALMATAGADGAVRIWDIAKRALLSEWRSDEQDRVHAQQVGLIWTREALISLSFSGVLVVLEPDTSMQLRGMLRGPTMSVVDLAADGNQIIAAASIDGRVYLYGKQGADRVPKEHAWPSLLRIGCAQRAFVVAALDNTLRLVSSASNADDEIVSLAVSGHPRHMHVCKNQVFVVTDKGIDVVTIGDQDDKASSGTSSQVLVPQATCITSDATAALVAIGSEDARVRLFRYEKASFHFLGELASGRSSITALAFSPDASLLAVGESSGKILVYDIEAQALKLSQWVFHSARIHSLHWSHDGAHVVSASLDTHIYVWSVAQPMQKAVFKNAHAGGTNAALWIDERTIVSAGADGAVREVRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYD5</accession>
    <name>A8PYD5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">MGL_1641</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731458.1">
        <property type="nucleotide sequence ID" value="XM_001731406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYD5"/>
    <dbReference type="STRING" id="425265.A8PYD5"/>
    <dbReference type="GeneID" id="5855765"/>
    <dbReference type="KEGG" id="mgl:MGL_1641"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1641"/>
    <dbReference type="InParanoid" id="A8PYD5"/>
    <dbReference type="OMA" id="YRQMQEY"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="745"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="243"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="500"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="423"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EDP44244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="852" mass="95226" checksum="C0FA8EAE4F0EC6EB" modified="2008-01-15" version="1">MERKREHGDIADTDTYAGAGAGADQMAYTHTSAREDTNGMNKRLHLDHDETEDPESADPNYRLLERYRKDAMYRRMREAKRDAARAREQEASLHEALARTRHSVLLVNQFWDALDALIRPTQRAQLSDGKDLAPISLTHTTEEQAAALAERRSMLEALLSQTTAAALAAAPSLESSSANVYDDKQQCITLTAELSAVRQAFETTRLRLVESQEHTEHVTELLRHAEKRLDRLMCESVRAVEDPQGYERMRAQNASQSASATNDDAGAPFSSKTDGSSSATRDAPASEALTAEKTAHVAVGRAGTSDMVRGPAFSSPAHAMQEELDNVRDLAHARQQALDAVRSELLEAQQACASCQLQLQHVPDDRVRAHPIYQALHADVAYMQQELDHVRDALASSESENASLREFRADFVHQTTTQAKTHNDELQKQLNARDADMARLRTQRDELNAELLERRSREGVRFAQIDEAKAFLASKEERMAALHAQVARLQAELEALRADAAGSHGQDDGHEHGQASDSAEATASGHSQAPAQLQRQLQAAHTSSAMLSDEVDRLSAAYDELVKQADARVSNAARLEDKILRLTTEKAKADNKYFAAMRARDALDAEKRALTRSAERQAKVIERYTETERAMQAQIQLAEKEVSALRKSVQMQASRLNETERDASTLRRRLAEAERARHAAETSVAQHLERATREATGRQEAMERASLLDREAGRLRRRVAESTVARRHGNDQDTNLEYLNSLLRCSACKERYRDRIILRCMHTFCEACVNARIQTRQRKCPHCGLAFATSDVQVLYCTYDVRLTRKCNEFVHLMDFCVCGLCNSASVSDTHPYWPSQMEQSYSKSRCCGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYI2</accession>
    <name>A8PYI2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731484.1">
        <property type="nucleotide sequence ID" value="XM_001731432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYI2"/>
    <dbReference type="STRING" id="425265.A8PYI2"/>
    <dbReference type="GeneID" id="5855791"/>
    <dbReference type="KEGG" id="mgl:MGL_1667"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1667"/>
    <dbReference type="InParanoid" id="A8PYI2"/>
    <dbReference type="OMA" id="GDCEHIW"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP44270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="307" mass="34089" checksum="97C01F5FC77A6632" modified="2008-01-15" version="1">MPDMMFDSPMLSNMDGELVLTQQLECLSEHTLDDLVHEIVCRNGELPYACHDSSDCPTHWTSANDAGPSVQPKYPKYHASPLPTDVCVMMDDKLYGRLDPSLDPSQSYVHAILEHTHPSTSPLAKAVYSGKTLSSTRLTQLRSLTLHQPNWLLHVGDCEHIWCIDGIRYVKEACLNSHVIVHDRLLGSNENAEIYPRTTYIQRWMLSSLVRQYLAPKKLVGRNERLSVPCDICDGTRDAVALVLGGDAVVCNKNGKRKLSGMPQLVMPCCAVCFQMATGTDVSHAWGPNPPSSEDNGTWTVMPLFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYS6</accession>
    <name>A8PYS6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731533.1">
        <property type="nucleotide sequence ID" value="XM_001731481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYS6"/>
    <dbReference type="STRING" id="425265.A8PYS6"/>
    <dbReference type="GeneID" id="5855840"/>
    <dbReference type="KEGG" id="mgl:MGL_1716"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1716"/>
    <dbReference type="InParanoid" id="A8PYS6"/>
    <dbReference type="OMA" id="RECWADI"/>
    <dbReference type="OrthoDB" id="3364069at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="317" mass="35519" checksum="5BDF021BD7ACDC67" modified="2008-01-15" version="1">MVFTIGTVCWYASFKLRPLFWEVVFVVLKVVGFLLSILLQNAQFNAVSPMLLSTLMALCRTLVVESLRIVSHEASTLILIALAWNEYGHLQPESFDAEPKCWTGVDDPRFILTLWLGCGWAFAEVLAGSYQLYKFVPMYRTTDRPMLGLGEEDLLTDFIDAAEEEQDEGSSSYLSSGRSSDQLEGMSLDELILMREKTELEDQLGEYLENVPPAIITLWRLDSVLWQLGTCLLISAAIVQAQGCASLDGNTTYRFLPFPPLHSMRWTFAIIVIIHTISVLAWLLVLPRLGLTNVTYSSLLVGLVLLSSGLGRWNVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYS7</accession>
    <name>A8PYS7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731534.1">
        <property type="nucleotide sequence ID" value="XM_001731482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYS7"/>
    <dbReference type="FunCoup" id="A8PYS7">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYS7"/>
    <dbReference type="GeneID" id="5855841"/>
    <dbReference type="KEGG" id="mgl:MGL_1717"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1717"/>
    <dbReference type="InParanoid" id="A8PYS7"/>
    <dbReference type="OMA" id="ANIAYIE"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="61"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="323" mass="36195" checksum="73459B3386DD4C02" modified="2008-01-15" version="1">MAKRGKGKLRTALANHTARSQQRAYENKKEAEREHKSKKSPTNLPAPRRAIYPFLRDDTILLVGEGNFSFTLALLSAPHHHPPHLILATSYDTEDEVYQKYPDARGIVERIRQIAGDHAPRILAFGVDAGALNKCDAVVGPDKNHAHRWSKVWFGFPHVGAGHKDELRNVLANQLLILRFLISAAPFLTQGRPPKYVQGTKTRSEKRRDDDDEDEESDDGSYESGHEPSEMPAQDVYANIPQIFSPPARQGSVLITIRNASPYTLWNIPMLAKQIRSVVDSIAASAPTLPKGVRPPSTADVDKYGAHMAWIQPPPDDWFRRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZG0</accession>
    <name>A8PZG0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1916</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730917.1">
        <property type="nucleotide sequence ID" value="XM_001730865.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PZG0">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZG0"/>
    <dbReference type="GeneID" id="5855224"/>
    <dbReference type="KEGG" id="mgl:MGL_1916"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1916"/>
    <dbReference type="InParanoid" id="A8PZG0"/>
    <dbReference type="OMA" id="LAQDYWI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1005"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1077"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1172"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1256"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1284"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="345"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="693"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1068"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1347"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP43703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1613" mass="179296" checksum="E955DECF80A8FF72" modified="2008-01-15" version="1">MAIGISVAAWFVSSLRDKERMRNEAAEEVAQLNPESSHFYGAIPRDEPAQEPTWDSTAAQTPDSAAKKVFQTENAILVDEALTLKDELYTYTQVEQHEVQRRNKRILELVGSLLLVLMYLVGAGTSNAEWERSWLFVWIYFAVLSTAAIIQRRSFFFQKLLLTTLASIVSLSNLRTSLLSSGVKAITVMTVLQTSVVLFLLGLSWTSPFTQALSSEMEALYETMHKRTLYSEIRTAVPTPPENAQNKQTDLDRLVPSYSKSHGPVLPPPEQHASLLSRCLFIFVQPIIWKHFFKPITLPDVPQLMSIDRSPSVIAMFRIHNGPETARPLWLRLVRHFAWSYAYQALFAFFATILTLAPVYFLSHLLNFFTQRASDGAEAAPMHMGVLYASGMFVSQVLFSVCQSQSLMTGRHICVQIRAILTFEVLSKTIRRGVSINKMDGSSATPKTSDDDTEDDDAPVTDGAVMNLVSVDVNKLSELAAYSHFLFPQQPLSVLLGVVYIVMLLGWSAVVGLVLLVVAVPIQTYLSRVLVSVGLRMLRATDERLNLTNEVLACIKTVKFFAWEKPFEKRMNEARLKELGLLRLQFFFSILNHLTFIGTPMLVTMATFGAHTILFKQALTAQKAFTALALFNTLRGPLAELPSMIQWLLSAIVSVRRIDNYLCEPDTHKYEQLLGEHSRAAQDVWIDRPLDKVGFDHATFTYGAEPEKAPEDGRFMLHDLCCQFPVGKISIVVGPVGSGKSSILLAMLGEMQRIRGKTIMPCPIARSLVEPDPISKLTESTAYCSQSAWLLGTTIRQNILFGTAYDEDRYHEVLRACALEADLEILEHHDETEVGEKGTSLSGGQKARIALARAFYSYAKHILIDDALSAVDAHTAKHLCKHCFQGPLAQGRTIILVTHAVTLMIPAAAYAVVMDGGHVAAEGAPKDLQAHGHIETPVEVQDAESKDSIETRPIDERELAARKKKTDEQRARKALADKNEEKLSRSQSSASLYWLYMKSVARSPYVAGVVWIALMSLYISIRAIDVSSGAWLRQWAGSYDQVTTTTYNTVHSWVLVAWHAQSGTVHDDKTWYYLKGYASIVLAFILVSFFTDVVQYVSSLKASQHLYSRLNKALLLATPLFFDKTPIGRIMNRLSRDMEDVDQELCPILQMTVENFISLVAIAAVICWATPYFLFVLGFVMALYYMIGAMYLSSSRDLKRIESIQRSPLYTVVGECIAGTITIRAYGDGERVMRQCLSLIDKWNRAFLLLWYENRWLSICCDLSGAGVTLIAALFLLFGGADAALAGFTLSYAITLVEVVLWLVRLYTNTEIHMNSVERIGEYITVEPERQGGLEPPAHWPTDSGAIQVRDLSVRYSPELPPALSNVSFDIQPGHKVGIVGRTGSGKSTLSLAFFRFLEAESGSIIIDGIDISSISLESLRRRLTIIPQDSQLFRGSIRSNLDPFGLTDDGDMWFALQRCQLAVPGSSPNVPGEGSVIKSLDDAVEQGGSNFSAGQRQLLSLARGLLKMRESRILILDESTANLDAESDALIQRTIREQMAPGATILTVAHRLKTIIDYDKVLVLGKGHVLEYDSPHVLLSDESSTFYKLCEQSGELATLKALAAEHAQSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZP4</accession>
    <name>A8PZP4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730938.1">
        <property type="nucleotide sequence ID" value="XM_001730886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZP4"/>
    <dbReference type="FunCoup" id="A8PZP4">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZP4"/>
    <dbReference type="GeneID" id="5855245"/>
    <dbReference type="KEGG" id="mgl:MGL_1937"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1937"/>
    <dbReference type="InParanoid" id="A8PZP4"/>
    <dbReference type="OMA" id="YAHFPMK"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="193" mass="21727" checksum="D8D36F8227B326EC" modified="2008-01-15" version="1">MLTIYKDLDLEIPENVTVELQSRIVKVKGPRGELVKNFRHMAMDFRLVKGPKGSKLKFIVWHAGRKHLACLRTAKAAVVNMFKGVTVGFQYKMRAVYAHFPINLIIAGDSRSVEIRNFLGEKRVRKVQMAEGVTIKDDKAQKDQVLVEGNDINAVSQSAAMLHGVTLVRDKDIRKFLDGIYCTAKTSIEQVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0B7</accession>
    <name>A8Q0B7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731010.1">
        <property type="nucleotide sequence ID" value="XM_001730958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0B7"/>
    <dbReference type="STRING" id="425265.A8Q0B7"/>
    <dbReference type="GeneID" id="5855317"/>
    <dbReference type="KEGG" id="mgl:MGL_2009"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2009"/>
    <dbReference type="InParanoid" id="A8Q0B7"/>
    <dbReference type="OMA" id="PYIPEIW"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="660"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="747"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="804" mass="89609" checksum="A5E2EA5765F2688D" modified="2008-01-15" version="1">MPATVPAATPSSTLVANSSESVPMVGSKNSSVVYLDVRKSPAQKSSEVSRRSPRLTQGMGMASAANTEATPPVLPPNADRVVATLMKLSAANEQTWLAIGSAAETMGDMARALGAYESALLHNPYSIPALSATASVYRSMDHFDLAVEYFQRVLDIDNENGEVWGAMGHCYLMMDELEKAYAAYHRALCYLPNPKEPKLWYGIGILYDRYGSLEHAEETFSSVVRTNPDYEKANEIYFRLGIIYKQQGQYESSLECFQYILNNPPRPLTGMDIWFQIGHVHEQQGAYDLAKEAYEHVLSENTDHAKVLQQLGALYMQPDSGFQNEEKALELLHLSLDSDPNDQQTWYLVGRSYMNTQEYSKAYDAYQQAVYRDGKNPALWCSIGILYFQISQFHDALGAFSRSIRLNPYIPEIWLNLGILYETCNNQTSDAIDAYRRTLELEPENTIIQQRLQLLQNAEPLGKAVPNIPLPKDIPFAAYATVGPVAPSTPPPNVAEADETTWSATADPIPVRDIPVEDERKHALESSTRHAYESHPRMHHASLSSYGGGTYSDYARHAATVHPSRMYSAPSEWDRQYAVPYADERIATYSTRLPSSKYPYDGRAMRYELNYQNGRSYHLPAASTPPLSRRVGAGGTGPVSPGREHDRMDMEQDNLIRRKRDIPNLRSSLPSRLPSTTESWAGETASEQHYPLDRGIEPPARNSFRTSGGREVDEDYDEGAASALMGLAGAAASAYEATSWARSRPEAVVGTVSRSPPLSVKRGGETDRPALEAKRRRNDEPPFVDERLDMPDPRSVHRSVSREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0K7</accession>
    <name>A8Q0K7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">endopeptidase La</fullName>
            <ecNumber evidence="7">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2047</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731048.1">
        <property type="nucleotide sequence ID" value="XM_001730996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0K7"/>
    <dbReference type="STRING" id="425265.A8Q0K7"/>
    <dbReference type="GeneID" id="5855355"/>
    <dbReference type="KEGG" id="mgl:MGL_2047"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2047"/>
    <dbReference type="InParanoid" id="A8Q0K7"/>
    <dbReference type="OMA" id="LGGACEW"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="10">
        <location>
            <begin position="772"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="864"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="987" mass="107879" checksum="D34A0282CED06E23" modified="2008-01-15" version="1">MAATTPPPIPSELVVLKLPYPLVLHPGLLLSVTLPQKQCFGILRTALAERRAAEQSNASSDESLEHGRQNNVSDQHPMIIACVPVLNPAGYVTERHRSRSLEDSSDWGCAARILRLVHSPTTNECRLILSGLVRIRVAKARVSRVQPDTFEPATIVSARPFFDPDVPLVSQELSPEDSRMRHAAQRLVALMGATNSPLLTSSALANVPLLPPSLLQAIASTIESNHSVSSPKLSDLLVGTLGGACEWEDRLQHLALPEANRRIEFTATMLEKAVERVQILREVLVNTPYALQDQYYGALVRSQIEAIVKQVTSMTSTGLTLRVMDNGKEASSSAATTRRENSSPGPRIIRRVIGLGPRRRGIDGPGRSDDDDDADDDADDYTHTSPGGDAASDEVKELSERCAKAQLTPEARRMCEQELRRLRRMPAQSMERGVLINYLDTMLDLPWDRITSDLRPEDIKALVPVSQVPLNGDEPLIERARQVLESDHFGLEKIKKRMLEYLAVLQLKTEQGAEKQSSRTYKGPILLLVGPPGTGKTSIARSLAAALQRPFVRLSLGGVRDEAEIRGHRRTYVGALPGSIVASLRKARASDCVMLLDELDKLSNGMGFHGDPTAAMLEVLDLEQNHTFKDHYLNVPVNLSRVIFIATANSLDTIPEPLLDRVDTVHVAGYTYDEKVAIAQRHLLPKQVAVHGLTLSNVAMSHEILMTIAQSYTREAGVRTMERRIGDVVRAKAVEYAESRGGSATYTPEISQADLLRILGAPSYEPEVADEVGVPGVATGMAYQGSGMGGILHIECAFLPPGTSALKLTGSLGDVIRESAELAFAWVKTHAFALGICADRDAEFPRNDVHLHMPSGATPKDGPSAGVAFVCALVSMYLRVPLDTRLSMTGEITLRGHVTPVGGIKEKVLGAHRAGIRKMILPRRNAREYEDDVPASVKSDIHVVYVRTIQDVLYAVFGASLETQISTLHGGLEGRRRLQELDWHSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0L5</accession>
    <name>A8Q0L5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731051.1">
        <property type="nucleotide sequence ID" value="XM_001730999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0L5"/>
    <dbReference type="FunCoup" id="A8Q0L5">
        <property type="interactions" value="684"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0L5"/>
    <dbReference type="GeneID" id="5855358"/>
    <dbReference type="KEGG" id="mgl:MGL_2050"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2050"/>
    <dbReference type="InParanoid" id="A8Q0L5"/>
    <dbReference type="OMA" id="YRYKMEK"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="239"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="442" mass="48971" checksum="FAAAADCC3B07E3A6" modified="2008-01-15" version="1">MTIVNIRRDVDDKFYRYRMPLLETKIEGKGNGIKTVVPNMSDIARALSRPPSYPTKYFGSELGAQTIIDDKNDRYIVNGAHDANRLRELLDGFIDKFVLCGDCKNPETDLKIKDGDILRDCKACGKRNYVDMGHKLVTFILKNPPPKRVKGTKGAGASSGQSVQTGNDEEAANSDDELTRRINAEASRIPTADQRAKEADADEDWSVDTSEAAVAARVKALEGAMNVLNVGAEDDEGGDDDDASPYAQFGTWILEEREAGKTPSAAEVYRKAQEMGIEKKHKTLQVLFQALFSENAPTEVQSYGPLLLKMVTSEKHQKSMLGGLERLAGLEHPSLVPNGVPKLLMALYQMDVLDEDVAQQWGTHVSKKYVDKETSKRVRKAAAPFLEWLEQAESDDDDESEDGDDDEEDDDEDEDVKKQTGRRAAAQSTSEYQKGDSDLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0X4</accession>
    <name>A8Q0X4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731096.1">
        <property type="nucleotide sequence ID" value="XM_001731044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0X4"/>
    <dbReference type="STRING" id="425265.A8Q0X4"/>
    <dbReference type="GeneID" id="5855403"/>
    <dbReference type="KEGG" id="mgl:MGL_2095"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2095"/>
    <dbReference type="InParanoid" id="A8Q0X4"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="111" mass="12633" checksum="23E20E0E57159560" modified="2008-01-15" version="1">MRYYFYHALTWPQLSYVAEDEKGKIVGYILGKMDEEPQDGIPNGHVTSISVLRSHRRLGLANKLMKLSRTSDHVLTSRNCHAGCVRSSICFASCARVQPCSNFIVHRHAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1E5</accession>
    <name>A8Q1E5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ima1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730776.1">
        <property type="nucleotide sequence ID" value="XM_001730724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1E5"/>
    <dbReference type="GeneID" id="5855083"/>
    <dbReference type="KEGG" id="mgl:MGL_1775"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1775"/>
    <dbReference type="InParanoid" id="A8Q1E5"/>
    <dbReference type="OMA" id="ERPMWDA"/>
    <dbReference type="OrthoDB" id="5966927at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="7">
        <location>
            <begin position="49"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="472" mass="52266" checksum="0258FCC753977B4B" modified="2008-01-15" version="1">MRRAWNWRRGKTAEATCHFCGTKSILVPPYGDACTARVAQTSSPVRLSSGTRARWFCSACESWNHTDAQGHIMDLYERPMWDASVNRSQLATTPTRTTSMNADEPVFCRKCLANQTLVTNLLASYLPDDDGNGNGSQDSVADDERMRAFPSYKRSLEERYPMVCATCSARAKSIIQAKDQQIQRASLDEWLVRRHVPATPVYTPRGVWRWRCEQSWWFLAHSLGLCIPLCTNDLMVAALSCLPPGPYDPCWLRAQLYRARDVRMYSHGTWRWTLVNISVWLARIAQYVGTMRTNSCAFLAWASSGTQVIALCYAYHVRHVTTEAPISLVSHDVPTQHGDTRKDPLAAMSLSDDRCPQAPLDSLLEHTKVPDTEAMDVEPMDIPTIEMGPQRFGGGRMASGLEDLFGSALSLATTETGSHGAVQDSSDSKKQSLIVLGMILGAAVVTGVLAIVIAIQGHVPWKRGLDARLGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1J2</accession>
    <name>A8Q1J2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730797.1">
        <property type="nucleotide sequence ID" value="XM_001730745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1J2"/>
    <dbReference type="STRING" id="425265.A8Q1J2"/>
    <dbReference type="GeneID" id="5855104"/>
    <dbReference type="KEGG" id="mgl:MGL_1796"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1796"/>
    <dbReference type="InParanoid" id="A8Q1J2"/>
    <dbReference type="OMA" id="HDEAYYG"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="606"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="845" mass="92401" checksum="CC155A95D960A5C0" modified="2008-01-15" version="1">MEDRAAKAERARKQLYRHREIQRRKRQSLLLEPAPSAAESNAVSSHAPASPKAATHETLISHPKPQTQLQPQPAVEAPTSSHVENPPSEPACEPAHFASELWSSDQPLEQTAAFDFVQPEETDASHGIKNQHQIPHPTEPAYTEPFNAPYSADDRSLPADDYDKPAAQLTDEPETVQEAEPATGLFSSAYEPATDSDFLSSTRHSSLDLFHANPHLRNLYAPSPQRPKSMDNFAESFEASVDEPTVHDTQDEQPNHAASSLFATADSDKSGTPATTLDYAPAVNESAQREQAYSNDAYTYDDAYLQDDVYDHNNAYGKDGAFELDDPYEQDYAYGHDDAYGQNHVDAHEYYAPHNYGHDEPYTSAYTQDYAHDVYEATADPSSEYHSDGHFDDPATFELHDPHDALPTAQDFDPEHMLEPISEQSQESNTTPPSSSSPKLQHPNTDTKDAQHGSADASGAPLGSGAASADHLFDQPLSSSNDALFEMPASSTAPGDPPHVADQLFAENDMPSWDDDSDDKNVPSVAQEDPAYATSEPCTKRSATADSASEPVATASAPASSSHLDELCTQLSNLQLAHDATQTQLTSVQAEYKSCTDQLHTVTAKLEALQADYATLLAAHTSLKAERDDLSQQSATAAKEHNDQVAHLETELAKLQEASNASRERESQYIQTIQAFEEEQQRRQSENTLVPVSAAADQGLPSRIDEARRSLSGTHGRTHKRSATTSAAAPRLPPLAEQELSVQLPRRQPTDKPRMRRNPDMPASQQHQRKTSLSMLRARMSSDASDATPFTPSLPTRKLSIVQTGDDNVASSVQNRVDMARTQSNQFSQDALLFCSSCKGDLIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1J8</accession>
    <name>A8Q1J8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730800.1">
        <property type="nucleotide sequence ID" value="XM_001730748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1J8"/>
    <dbReference type="FunCoup" id="A8Q1J8">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1J8"/>
    <dbReference type="GeneID" id="5855107"/>
    <dbReference type="KEGG" id="mgl:MGL_1799"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1799"/>
    <dbReference type="InParanoid" id="A8Q1J8"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14492" checksum="CCCE513F65CC0C7C" modified="2008-01-15" version="1">MAKVRTQDLQNKSKADLLNQVAELRKELLQLRVQKVAGGASSKLARIHTVRKNIARVLTVINLKQRANMREFYKGKKFQPLDLRPKKTRALRRKMTKYEVSQRTERKHKKDVHFGVRRYVLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1R1</accession>
    <name>A8Q1R1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_1826</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730827.1">
        <property type="nucleotide sequence ID" value="XM_001730775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1R1"/>
    <dbReference type="STRING" id="425265.A8Q1R1"/>
    <dbReference type="GeneID" id="5855134"/>
    <dbReference type="KEGG" id="mgl:MGL_1826"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1826"/>
    <dbReference type="InParanoid" id="A8Q1R1"/>
    <dbReference type="OMA" id="QRWYRIW"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP43613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="723" mass="80292" checksum="91E5D9A2B3BC19EC" modified="2008-01-15" version="1">MDMSEIRAKTADAANTVASKMQEEARNLANKTSERAQQLSEKAESTGAQDSLTGKTARATEKLSHKTSEAAERFSSSLDRRADDLRNINAKESDQLHEESVSANAAAPVAHEGGSVTTGVQPSTEVDSTLHAPTASFAPAPVQETTVLEGHGLVDPASASTVTNVSSTGLDQTLPTEPAAVRSGQSASEKPAAYTATSMPSAEAAMNLPTRTAHATESTTMPFVSNSASASSTSQPRMAPGGKVRLTNYPTIKNAVLPAEGNGSFNNMHLALLVLLGPAVLLRLIPFVKASWFGWRSYILLVAVLGVPLTIAYWTIMSMTGPRINEKVTLPNRPIEDYLDIQDESLRRKYTGYNKIPMQIFWDAYIDGKIEVKGDLLDVLEYRWDWAAMHFTPELFRYVLFKMLPDVLMHSSRQDEEQIRDNYDRGNDFHEWFLGPQMVYTSGLISDPNREETLEELQDNKMNLVCSKLALKPNDRVLDIGCGWGTLAAFAAKNYGANVTGVTLAREQAAFGNERLQKNGISEDQARILCQDYRDIPVQPGHYNKIVSLEMAEHVGIRHYAKFLKNVYNLLDDDGVMVFQVAGLRPRWQYWDLIWGLFMNKYIFPGADASCPLHWVIGQLEYAGFEVRSCDVVGIHYSATIDRWLKNWKKNEAKVKAKYGDKLYRLWHFFLASSVIIAREGGSSLFQITVTKNLNATHRIEGVESHGNLLPRPNRGKNYQSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q271</accession>
    <name>A8Q271_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mur ligase central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730702.1">
        <property type="nucleotide sequence ID" value="XM_001730650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q271"/>
    <dbReference type="FunCoup" id="A8Q271">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q271"/>
    <dbReference type="GeneID" id="5855008"/>
    <dbReference type="KEGG" id="mgl:MGL_2156"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2156"/>
    <dbReference type="InParanoid" id="A8Q271"/>
    <dbReference type="OMA" id="RQYIDLC"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="57050" checksum="24488F9382C02147" modified="2008-01-15" version="1">MDLGLGRVQALLRRVGSPHVRFPVIHVAGTNGKGSTTAYLDAFLTHAVGIRSARFNSPHLITARDSVRINGGEPIDDLTWNMAVRQTCLADARDVPIGATPFELLTVQALLAFTLLPKSQQPDVLLMEVGVGGRLDATNVFPDDHVLASVICPVARDHETILGNSLSDIAREKAGIIKPHGLCVIADQAPVSYCDDTQDSSFDSMPADLASSDILRVLHKMCCMKQARVVYSRVASSSISSSRQTEPHVFEAPIELHVPLYGAHDACLSEDFYAHREPEAHVSVPLEATVARISGASTALQTLWSVAHDTPSGQTIVSDAWHQLRAQIRTHLFESHPDVSKMAIACAARQYRWEGRCEWKSLLDSSGTSIPVLLDGAHNQASALALRQYIDLCIANSNMTSLTITWILGFSNGKDVKGMLHALVKGQKRVSHRFLLVPFSTPVEGMPWIKPFAPDAIVPMVEDMRCNIKSVATYATLKEALDSVTHAKQPTPLASPLRSSPQIVVVCGSLYLVSDYYRAMKSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2G9</accession>
    <name>A8Q2G9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730399.1">
        <property type="nucleotide sequence ID" value="XM_001730347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2G9"/>
    <dbReference type="STRING" id="425265.A8Q2G9"/>
    <dbReference type="GeneID" id="5854717"/>
    <dbReference type="KEGG" id="mgl:MGL_2194"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2194"/>
    <dbReference type="InParanoid" id="A8Q2G9"/>
    <dbReference type="OMA" id="ARIFACW"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="631"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="972" mass="107741" checksum="851A01D21C94B6D8" modified="2008-01-15" version="1">MADAWPTRLASATQWQQVIEAVLLPLARVHALPAQYNQLAKDAPTDPHWISTWWSTCQHTLLTVTLVTWAPGLHEHNLYETVLDGWFIPSNASTVWVYTLQTCSALLRGRVDCHPATLDALYYVLTRLDPSTLLRHMLEAVHSEPHAARRDILWDDAVANVSALPTRVANMFGPHRDRRSLLDMYGTWLGDMSAGIHDVIEIDPSRIARLLTRFARTGALLQRVPPTWWDQMLPHIQSSLESTTTIASHAKKAWHAMYDACDPSTQEVLALSLAYALNARLNSTSYAWPVAQQERAPGTEGRAFLTTEAWRWAYTAYLVLQTVLGTAEAPRLPLVHVDKAHAHTEWTPLFSIALAAWACDADARTSLQELIHVWSHPQHVAHASYTHAQSITLMVLMAIRITYENKTALTTHAQSMEFLQGVSAYLEHTDARIRRLGMLVAEILSQATNAAPLKFPAEVWDGRGDGRGVCRVLRAAYEREGPFWPDTRPFPWRDESTRLLEQMQSLSTKGTNAFAQRIAAEEAPRPRRRSSPPTLRLPRRVPARVLIEEVHPQEGARASPRTERNASSLNGLYIYDEESSDSDASDVGADKSARVDSGVRTGDAVEEEDPYDPQDSSTMLGDALRKKPRVPVYIYELAPLAREHDYEANKCVLKHAESLIRRKTGWGYEIAEHAVDLATALASMQDTYELRDFDLKRTRALSALCVAAPMPVVDALYEQFFSPHYSLAQRLSMLRAVAAAAMELSRDGSSSGSAATAPLPDTTEMTGRLMGAAMSRMQQTGEARIAASYASDMARVRSASMKDVPFAPAWSVRPTVPFTAVASSSFIFPLIRRLDHARQTASRMYAGSDTTLTPNSTSAVLYTLCVLCWCGRNAAFFPTRTLPEVLGVVDVWSSNSSNHADIWTASMALALVLLDIAVEHDGGLHLVRSHTPMLLRLQAVAQASLDTSPQAAAVVLCITDMQERTRGAFLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2W0</accession>
    <name>A8Q2W0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730454.1">
        <property type="nucleotide sequence ID" value="XM_001730402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2W0"/>
    <dbReference type="STRING" id="425265.A8Q2W0"/>
    <dbReference type="GeneID" id="5854761"/>
    <dbReference type="KEGG" id="mgl:MGL_2250"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2250"/>
    <dbReference type="InParanoid" id="A8Q2W0"/>
    <dbReference type="OMA" id="ATHHGWI"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="695" mass="76176" checksum="CE87EE9265CCF038" modified="2008-01-15" version="1">MSADPHFLDSARRVKAQPHEHNRLQVRLDVPGGVTFAPDQLFPHNATKRVFQVPRLPEPSYSYYNFEREICQHNGVPYVPSSAFVLGDEDELTPSQKLAQEVREKEAIKTTPSASTDTAALIPKNEEKLDSLIQAMGLNEPHDHAQQAKSQDMSSAPAGSPASEDKRDALSKASESPSHEVKRIASKPKNGPVTNATLDQGASETPAHTGGEQMKPIDSAKKNFEKNMTKSQAKRAKARAKSRAKKMAEQAHEQDESRLSTEQAEQHQDRYELGDPTASQPDQASAKIQNENAGSTDRAHKQRVSQNEDVYADEGFKSSETSTSTEQTPFSKNKISDTTTSAKAEQDTSARQSDPTSVSQPADDPSEPSSDHLTSSTLHDAHASLDKGVKENTRVVSSRPTADTASLRTSATNLSTCAPTLSGFSVMAEEARHGKSDGLPSVVRQHLFTTDYKPPPSISDSSYSKKPWNNKSYSTNRTFEMLSNQPAGRDAGSQWDAISGSDSIGARDSHASSTSLDTIATLFTPDPRPWHPYRFVRRTNPRQVLLFCAGTALTRQQIEASEQTRKTAAVNGTASISLPESADRAADSKSLASYFATTENTNLQGGLGFIYSPCESLCRAMNQPIDLARVEPNFSRRLERPEFPHETTKRRAALRSVIAALEYIPWEEEGFDKIVIATHHGWIVRGIAYEYVDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2W4</accession>
    <name>A8Q2W4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730458.1">
        <property type="nucleotide sequence ID" value="XM_001730406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2W4"/>
    <dbReference type="GeneID" id="5854765"/>
    <dbReference type="KEGG" id="mgl:MGL_2254"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2254"/>
    <dbReference type="InParanoid" id="A8Q2W4"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26805" checksum="B645121AD29B063F" modified="2008-01-15" version="1">MGGITSGSFICFLSAPFELTKVERQLEYLIWTQRHAQNGLKAPPFVARSGIKAAQDIYTTYGGVRGFYIGLRLHLFRDMTGSSIYFGLYDTLRMMSDRLEPYRQRWGIPAPVVSFLIGSASGILSWLTIYPLDLIKTQVQRDVLAGAPRRSAMTVLQRLLMQKDSDPQPMVKTRSVLELPISRFLRLYRGLGISALRSFMSHGITWMLIESITRHVETEMLNHDLDVSYDFVDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3B9</accession>
    <name>A8Q3B9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730560.1">
        <property type="nucleotide sequence ID" value="XM_001730508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3B9"/>
    <dbReference type="STRING" id="425265.A8Q3B9"/>
    <dbReference type="GeneID" id="5854867"/>
    <dbReference type="KEGG" id="mgl:MGL_2356"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2356"/>
    <dbReference type="InParanoid" id="A8Q3B9"/>
    <dbReference type="OMA" id="MFEPTPP"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="165"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="348" mass="37700" checksum="768E33908F204994" modified="2008-01-15" version="1">MTGLLLGRCARQAVRTNAALLRARSSWRWESTEAAATAAAGVTRSNESRLTKADVAHTASPVSETAMQRALPILFNTEELARFPDLLKEPKALHDVPVYQYEATEQVPYTNSVTMYNETERPYFATPPPSVLAVMTSGSDLGEEVNSESYLSSVTPLSAMEIRQLHRYNITIKRVVNMTGKGRVPSWYSLVIAGNGRGLVGYGEGKDTNIGRANKKAFHAAVKNMDLVSVHRSKSGANTVETPVEGHWGATRVAIRPRPAGFGLRVPNVLHPIARAAGFTDLSAAVYGSSNAMNVIKAALQVLWGGSAPIGMGGGVRGKMRRGDRGQGARTRRDMELSRGRRLEELDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4M5</accession>
    <name>A8Q4M5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730194.1">
        <property type="nucleotide sequence ID" value="XM_001730142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4M5"/>
    <dbReference type="GeneID" id="5854501"/>
    <dbReference type="KEGG" id="mgl:MGL_2576"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2576"/>
    <dbReference type="InParanoid" id="A8Q4M5"/>
    <dbReference type="OMA" id="CIPSRVD"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="131"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="681" mass="76155" checksum="42AD5897E69EF545" modified="2008-01-15" version="1">MSGIAREDGDMSLLTLSEEASASMQLEPVTGTSLAMLQRWMLSLACVNFDLELGPDVEFMYPPLEISKEEKDNIAFSSFPDTSVFSDGNLTFSWRVREVPLVFSAERAPHIPDKPTSHRPSSSLSASSSSRHASSSSARRRSLSARQSMSRRISWLRGRPNTVPAKSPSDTSTASHAASSSSSSSSPTFPTSSSKSMHSHSRSTSYLYGYTFFLQRRDPSVRRGYFQKSLVILTHLPYVGLFLQLIGRVGPAFFELGLPVLESFVHEVMQWPAPEPGATIQLSALGTLLHASLPHGNEAQNGDGIRDGTDAEHPILASVPPTGLVHVFYELLPDLWRLWECMLTAEPVLIVGHDPRTTSEAVWHLMDLIRPVSLAGDFRPYFHIHDYDLRAFVGRPTPPPGVVLGTTNPFFLQTCSHWPHIVQLGRRHDEMHGRLVSNQTVRVTSTSKRRISKDQALIKQLMVWRSSPDQFAHANVVLRRYFADLTERFLAPLHQHLATLIPASFDLSSPAEAPRIKPFHRETFLQWLKAHPGPLKMRQRSLLPASVLRQSLYADFLESPNFAIWLHERVEAAQEEQRRRRVSALAIGDVVAFGRTRTEIESVDLYLRLRDELQAMDEALARPTLLTTGPSERWRASVPASGDKCVPAAQSRSMKAQRARLAEQMERLLSTLPHDLRVGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4R6</accession>
    <name>A8Q4R6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730235.1">
        <property type="nucleotide sequence ID" value="XM_001730183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4R6"/>
    <dbReference type="STRING" id="425265.A8Q4R6"/>
    <dbReference type="GeneID" id="5854540"/>
    <dbReference type="KEGG" id="mgl:MGL_2617"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2617"/>
    <dbReference type="InParanoid" id="A8Q4R6"/>
    <dbReference type="OMA" id="WIQRWLA"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115916" checksum="2E7C7A0A232467CF" modified="2008-01-15" version="1">MASGRLRSRSVRHDSSLPLFVITPAESQGTASAEPPQGQDLLLSPSVADVTSPYVQDLERWTPAPEPSFSRERRSNRTHARTGSSGVPQNRSSSPLPSLPQPCGPLEGVQAKLLRYETDVFKPHNWRRWMGINTLKSVSSLPSLRLRSSSNDEPPSIVPTREARAESACSDHPLDTIGVLHRESASLTPTASRTTSHRRSLSIPTTRNPSPDSFPRGQAVSFARPPMSEDQASLGPDETRSQHAGRRSSLSTEDPGAIHAKQVSSLSRRAVPISSAAGKAPLIVQPQPRVPSALLDRRWSGQDSSTSSQGDDTSDTSDPMDNDANESIQTLSLSHCNVLTNKELHASRRKMRKLPAELRDENASRPDSTSAQVVRSSRVRHTPDEVGSSRATTPNRTPSPFMEGGVGTRLRPALRTPQRSTGGSWSDENVAPERESVVTPPASSAGSNRPHMWRRRERRAWNQASVEEEIDDDEQPQPRPVHRSSHVFVSPVQSDTPELVYDMLHENQRGIVLFGVSKRFSSNVLFVWDPSPWTDADGCNTALDTSTMQLPDSTWEWVHPTWLVDMTGNTDEDGWQYSGSFTGLRFWRKPIQSAAKSGPRHWWQTLHKFAQSIDANLMARRESKEASRPDEGMEAFMRSVRSRSEKWTSKPGIWTFVRRRRWVRMRRRIGNAHLSKGLGIPTADGSLVLVSETCATSDNASTNDQVLLGFESAIEDDVDNDEQNLTEKQHLLVAIERLHHLLPFFMIPSSHLAEALPPTQPLMASELEKWSRHFRFILEEETYLQNPFFALGWIQRWLARPDLKDLTRRLRQQERTYQKTYVSSAQRNDRTDQQLMKEKMLQCEQCLSMSTTLSLPTKPTVDVDEFYPHRPSSPFTPSECLLLSSRGCCNVRPSIVRQAVVEHNFAMVMNLMRLCLVDRLRVDLWLMWLHGCLNAPDDSHGAELEGSLSLLQQEWYRRRSMLHDMQRLGRTPAAFSPLIERILRNRIYDYTHSAPILLDVWDILVAHVCTICLLIPDLVSYLHVSLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4R9</accession>
    <name>A8Q4R9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ams2/SPT21 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730238.1">
        <property type="nucleotide sequence ID" value="XM_001730186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4R9"/>
    <dbReference type="GeneID" id="5854543"/>
    <dbReference type="KEGG" id="mgl:MGL_2620"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2620"/>
    <dbReference type="InParanoid" id="A8Q4R9"/>
    <dbReference type="OMA" id="EARWQAC"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057725">
        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25823">
        <property type="entry name" value="Ams2-SPT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ams2/SPT21 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="990" mass="104907" checksum="8582427764CD0181" modified="2008-01-15" version="1">MISRVARRVPVRIARKQGSNSLLGRVSLKTCLNAICLASPELLLDKSNDYIVYAVDPEESAPRPVSTMSSPSKCDMSLQVFVGKGFFSNGIAEPGDGTSYVTGQVRLESRNSSAFSSDEEDTPGTQVLEVVLRMKEASQRGREQYQSRMRGIASSSTSLHMPTPASAPVSISESSLTPTVAAGVHEPDLHAVAIDSAPESSAPTPTTQVLQVLHAMQAHQGSLSQEQKSHLMGLLGMVAGAVQSGALPAPKDTTQAISSSDTPGDRQSWHSTPSPGPAAATPSCARNEVRNTRTSRPGLGDIRTELPRICYNCGTTQATTWRILTLPSGITINYPASERPPSDVVPLTWTSKHPNKGPIQSNCEARWQACNPCGLYFAKYGVARPEYVRNFVARPGKEDKKRDVAHPSPPVQTKRAERAERAERSKRAKGMPMMPSSRTGFTRTLSAVANREAERLQKQRRHDENMPPWSIPLESTLKSPTQSRSSRTGTSDTTVERLPGGMESSPCTVLQSLLSETEPSRTSVAPVLPPPQSPCRNASTLDDAQLPPMTSPVRRSPRKQPPGTMADVNPYATMLRSASSPVSKKVGSSAQIAAPREALTSPSDRAAHMLPPVNPFMGLAMLDDDIDTFGGPPSPSAGRTSRAKPAPKREIRTPSRLPREDSWPSHLHTSPTALGLAEPLPLAEQSTFKDLFAEHTHDHWLGAWNAPTSLTPAPSTGALKFGAPEPTPENTFPVSASAHAGGKPTTESTALASPTADDQATSPAPESVPLLSATSSSSSLVKRPPRRPMPATVEDASSSHSGSPPATSPDVDDSLVDLIEDPYGLLSTCGIGVLQPDRIAEENDHTHNERQGTTGLVLGHPDISGCSVDAFQGIELYNAPSFSQQLDAFTQSGHLGIAAHMNAGQDMSTALTTAEPQVFTFGHPSSSTQPASSHASAFAGQTETTNLESLLDDPTVQAMLHSSNAGLAPSLSHSAAAATSAPTTPTAITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4U0</accession>
    <name>A8Q4U0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730255.1">
        <property type="nucleotide sequence ID" value="XM_001730203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4U0"/>
    <dbReference type="FunCoup" id="A8Q4U0">
        <property type="interactions" value="615"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4U0"/>
    <dbReference type="GeneID" id="5854560"/>
    <dbReference type="KEGG" id="mgl:MGL_2637"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2637"/>
    <dbReference type="InParanoid" id="A8Q4U0"/>
    <dbReference type="OMA" id="WQFDVEI"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="224" mass="25527" checksum="CF5E12C0FF1E4741" modified="2008-01-15" version="1">MATAQAVGLQAPTRTHLTLKGSTALVHEFFNYSVQSILYQRSIYPSEDFRTVKKFGLQMLATTDDDLADYLDRAMQQLKKWLEQGKVRRLVVAIVEKESQETVERWQFDIEVMNEGLTESQVPKEGDQIPKSLQKTDAQVKAEIAAIIKQITASCTFLPVLEEPCAFQILAYTDRDVEVPMEWSDSNARLIAEGKAEQVKLRSFSTHVHRVDAMVAYKREEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q546</accession>
    <name>A8Q546_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730338.1">
        <property type="nucleotide sequence ID" value="XM_001730286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q546"/>
    <dbReference type="FunCoup" id="A8Q546">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q546"/>
    <dbReference type="GeneID" id="5854643"/>
    <dbReference type="KEGG" id="mgl:MGL_2720"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2720"/>
    <dbReference type="InParanoid" id="A8Q546"/>
    <dbReference type="OMA" id="EEYIRPQ"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="5">
        <location>
            <begin position="645"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="722" mass="81071" checksum="5107313BB3DCEA1C" modified="2008-01-15" version="1">MAKRPGRRSSRQISPGTRSLETRDDIPKSDVDAFDASRDEILLDDNAEEDPRLDEFDGDTQEVLGMNLDDEDDDSNDESDHNVGDEQDDEKEEDDDLGRYRTMILPSSVTESSLRRRAARDDAHKEQEEEDILDNDGDDDENEYLGWGKDKRSYYSSNTMEDFESDSEVDEEKAHELETNEAVRLQRMSRSGMHDEDFGLDSIHAEEAQVAADEQSEAARVKRRHEFDMDSGAESKAQSMQRPDELLASLQVRAPIVLALIDEYNDALHQLKEECKTVDAMSQHGETQIVEIAHLYIQSLSSYTMLLAFFFQLASSPNMLADPSALLAHPVIERLSQLKQALVEMKNLGLFEPHLEEADVDDSNRVMGKPTEEDAAYEELGDLEPNELQDLIFDEKENQAESQRQSQRSVSASATKPARGSSSEMSKKTKKQSSPRASVPTQPTVLADVADVDVKDDDGFPQLQRAKRPSSHQVLESEDAFGEPSQMRDAELHDKAQRKRAVQFHATGLEAKPTTSSTKKTLLEGDADIPYRDKKQIRDAVSTAKANRLAKGMEKADTSLSETDWGESDWRTRDEVMRDDAVRGEDEDDETDGDDSESGKSNGAAAYYDLVSSRKRARKAEKKDEYDRQRLANRVYDDDVLGPGEHRSIDYAIEKNKGLTANRPNSVRNPRVKRRLRYDRAKKRLSSTRAVYKGGQSALQGGYAGEKSGISTNLVKSRKLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q595</accession>
    <name>A8Q595_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_2757</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730375.1">
        <property type="nucleotide sequence ID" value="XM_001730323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q595"/>
    <dbReference type="STRING" id="425265.A8Q595"/>
    <dbReference type="GeneID" id="5854680"/>
    <dbReference type="KEGG" id="mgl:MGL_2757"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2757"/>
    <dbReference type="InParanoid" id="A8Q595"/>
    <dbReference type="OMA" id="GHPLCQM"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="152"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="19">
        <location>
            <begin position="412"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP43161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="449" mass="49258" checksum="A5C5847BF55AF82B" modified="2008-01-15" version="1">MTSAAPASTTAVPTSAPIPIPTHQPSVSVGQATAPVSPSAAGVPPSKSWHDPTSLPPPPPLSSSAQASQPLPASPATEPTQSPAAHSQRSSMPSAGGLAPSAQTAPKQTIVTPPAPSSVPPSSMASSIATAAPPGALEFPASAQHNVSLDDFNFLAVLGKGNFGKVMLAEEKRTGALYAIKVLKKEFIIENDEIDSTRSEKRVFLTVAREQHPFLLNLHSCFQTETRVYFVMEYVSGGDLMLHIQREQFNLHRAKFYAAEVLLALQYFHKHGIIYRDLKLDNIMLTLDGHIKIADYGLCKENMWYGNTTSTFCGTPEFMAPEILLEQRYGRAVDWWAFGILLYEMLLGQAPFRGDDEDEIFDAILEDEPLYPIQMPRDSVSLLQRLLTRDPARRLGAGPNDAEDVKAHPFFRDINWDALIQKRITPPFCPTLRHASDTEWFDTEVRTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5R5</accession>
    <name>A8Q5R5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729822.1">
        <property type="nucleotide sequence ID" value="XM_001729770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5R5"/>
    <dbReference type="STRING" id="425265.A8Q5R5"/>
    <dbReference type="GeneID" id="5854129"/>
    <dbReference type="KEGG" id="mgl:MGL_2808"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2808"/>
    <dbReference type="InParanoid" id="A8Q5R5"/>
    <dbReference type="OMA" id="WINDTRC"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="373" mass="42619" checksum="F460224F36048990" modified="2008-01-15" version="1">MQDEHMDVIASGDRHADAEHINRRILYNIPDELQESNGPKESEELPEAPTKQAPEPGAAPAMPTLEHGDSIRFDALHLEGGPITQLSTSRLMAFVAYSGAHAKGIEWINDTRCVIVFNSYERAVEGLRHLCYEAVEDALIPSESGSLDSESMLLRPRLVMAFPHKLYNTMEQQAAQEIPHLISKLEEERARLDDAAEPVPEIYRDMELEEAERRIFSQDHLRVRQLRQSLWLRFALQNHDTKSPRSASRSNWYKQHGRGAGKDIVTRLLDVGDASSSQPRGRSSRRERRELFDKGTTAESLKEEEDYTPLSLRDRISGRYDRDWNTDHDPNPYEGQQSRERSASPESHGGLRIRGRGSRRAQHSRMHGWNDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5W9</accession>
    <name>A8Q5W9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729839.1">
        <property type="nucleotide sequence ID" value="XM_001729787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5W9"/>
    <dbReference type="FunCoup" id="A8Q5W9">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5W9"/>
    <dbReference type="GeneID" id="5854146"/>
    <dbReference type="KEGG" id="mgl:MGL_2825"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2825"/>
    <dbReference type="InParanoid" id="A8Q5W9"/>
    <dbReference type="OMA" id="HITAFRE"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="445"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="515"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="59458" checksum="58D54F4BB6A95462" modified="2008-01-15" version="1">MIKQLSSSNNVKVPLGVKDAKGRAKSRAYLQQCLQEIAYLTSNVTLNPIANQSDTTDAKGEASHPSRPLFHIPGAESSTENKNNSNSNHQIQDLHTNNFNQQKDTHDYRYSYDVSQTHGGQSSTSAVKSAISLNPSVDNCAQKLPESVQECKPNLTPTLDRTIDSSTEKLATIPDVQLWNPRGTIMAHFDSVRSLAYDSFGHGLFTASDDCTIKYWHLLSTESSEGASDDPVVEQLTTMRGHEAPVTCLVCSRKLNVLFSGSQDTTIRQWILPNDTPTKHSSALDAMDQIILPGNSGIVWDLALFPMNAQEDSILASVSADGMIRLWSTDAKASPRLFLSWDYFGTQPSKEADAERQSLTCLPVPKSVTKCSADLKVCVVAFSNGIVKLFELASGREVRRFNPSLPTSQVRAVVGHPTLPLVAAAYEDKYIHLYDIHTGSCTLSLQAHDQGVACLDIDPSGLTLVSGSHDGKVRFWDLLKSSESGSTSATASTSNTAASNQEYTAVCFQELSPHQMKQNEGVLNVTYHPSMPFVATAGADGTVHMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q678</accession>
    <name>A8Q678_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729888.1">
        <property type="nucleotide sequence ID" value="XM_001729836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q678"/>
    <dbReference type="GeneID" id="5854195"/>
    <dbReference type="KEGG" id="mgl:MGL_2874"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2874"/>
    <dbReference type="InParanoid" id="A8Q678"/>
    <dbReference type="OrthoDB" id="10319305at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="421" mass="46766" checksum="3719D74B2BD29388" modified="2008-01-15" version="1">METSGSLIWVCHIDTEQCVGIRSPFNTYSRRSVWFQRKAIIITAIFLALLIILIIGLAVFLRDIGVGARYDDSDDETLDLDDEENEDHWGSHSRMSQRIRHPHKLFRRRLRRRARVSNRAHRHLRPSRHASEMQVDVSALDPPIPHAMHLTSPVPQEHVSDTTASPQSALADSSRTRTPSSVRSPSRYPRTSTNIDQTDIDAVDALPMDPFATVPPCYGTVNVREQRMREKLHPMQSLSESSSSSRIHDQCVESAPETSALCAHISTDEKSTLEALYNASSAPALNLTTNNEALAPPTAPEWTDPQDNSHVQQGSSRRNMLPGPPVSFESRYDLYAPLASDTKAQEAEAERAGLATLLPSMPGLHPTDASYLPVTYLPQYDQHASNERDVADLELGLRAPSPANTEDDMLPLPSAPIMHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6C2</accession>
    <name>A8Q6C2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2918</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729932.1">
        <property type="nucleotide sequence ID" value="XM_001729880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6C2"/>
    <dbReference type="STRING" id="425265.A8Q6C2"/>
    <dbReference type="GeneID" id="5854239"/>
    <dbReference type="KEGG" id="mgl:MGL_2918"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2918"/>
    <dbReference type="InParanoid" id="A8Q6C2"/>
    <dbReference type="OMA" id="AFANDCG"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="274"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="666" mass="74126" checksum="2A7677394F6FCADF" modified="2008-01-15" version="1">MPIIDVTSPTASMTEGPGAINHSASMAPAHHVSPPENQGLGLKGISNFANIESDEPWSYPFSASNMQRSSSSTRSLHTLSDFSSELLTALPSPMISSHGSQGWVEVHPSDTKTDAFFNTVTAAPSPPKPPPSISRSASSRAPSTSSPAKELSKRRQRALSSPQRPEPCDIVSGGYLETPLKHAILPIRSLEPPASAARLQHHTMTETRSGARHIHGPSIHMRSDSISPLQDAAVSDANRQSEQQRECMLDDKLLKTIDLVTEEEDESSGRVGPYQVMSLLGTGAFSKVLLAKPVNSSNDVRVALKMIACKPGKVDERMRVSWVREAEILKRISHPAIVSFYRSFRTPTHYTLVLEAVNGYELFELLEKHQRQVAQREWLVRRIFGELAHVVHWMHSINLVHRDIKLENIMLTNAFFTTSTKLTSNELGPMPLIKITDFGLARFVKADQMLETRCGSEEYAAPELILGKNYDGRKTDTWAMGVVLYAMLFGAIPFLSSSSQENAYSESAFRNARERNGPDVYHENRDRKAHLLRIVKGELRWPEHTNELCEDEPTNGGYDPSLRLVTPQARHITARFLRRDPKKRATCLELWRDPWFLYGSFALPSAAHPQPCGDAMMRCTAYETSADDFSVLLPCNPEDAPGRQWVETHTKGTGGKESTVMHHENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6J9</accession>
    <name>A8Q6J9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730003.1">
        <property type="nucleotide sequence ID" value="XM_001729951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6J9"/>
    <dbReference type="FunCoup" id="A8Q6J9">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6J9"/>
    <dbReference type="GeneID" id="5854310"/>
    <dbReference type="KEGG" id="mgl:MGL_2989"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2989"/>
    <dbReference type="InParanoid" id="A8Q6J9"/>
    <dbReference type="OMA" id="WIIAGYE"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="286" mass="31464" checksum="70DFAE33BC100AB8" modified="2008-01-15" version="1">MPIRPPLTPAWIVRHHAPAPVHTVAISNNGDLLLAGDSQGRVSVTHLSYYRPLVFWKAHKDTVLRVDAWAGYLVTHGRDNSIRIWKMPSEVGSATFSSSMVTNLPEPTLVHDMGVNALNYCAYDMTLTKGDNLTLKGWLVTPHTLDSAWLDVYELPSQRRIVEALGRNSPPSTSSIVPGPAAQERRPPVVMSLQTCFVEKVLWIIAGYEDGSLRAWTTSLSTSEPMLMWAHKSHAEAIMAICVSPKLDSVLSVGADYHIVRTSLTPNAVPEVHKVRRPGNACTATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6K2</accession>
    <name>A8Q6K2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730005.1">
        <property type="nucleotide sequence ID" value="XM_001729953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6K2"/>
    <dbReference type="STRING" id="425265.A8Q6K2"/>
    <dbReference type="GeneID" id="5854312"/>
    <dbReference type="KEGG" id="mgl:MGL_2991"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2991"/>
    <dbReference type="InParanoid" id="A8Q6K2"/>
    <dbReference type="OMA" id="RWTRRIY"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="7">
        <location>
            <begin position="85"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="506" mass="58377" checksum="50131945C608BB08" modified="2008-01-15" version="1">MTSPANGPEPVTEANLAKLNGSSPTSSDQGSQDMQAEKQSQARSAKTSMTFSQRTMESMNSILVRSLVAVNAEPERLPTQKRKMPLSLPTTALNFRGFVQKSGPVFVFQDSVESTLMWDDWPWTTMWMGIWAVVSLNPRLLVCLPPVIAITIMCNTFFIRFPIREDDRNLSPSDALRKSLHMPDLFQAEPQAPPIEPRPVMENDIKYLMHMRDIQNMMRLIIDGYDHISPVVKYLNWSDVRRTLRIFQACIVLLLVTYFIAPLIPWRLVLFFGGELALVAHHPWLKPAIEAIKKQSNETPGKYQRAQRQHRLKQRLIDILDEDRLPEYVWQRGWKDVELFENQRLQLDRRGGADESRWSAQNLLCGERRPWTRGSDGFSAEGNSPPEYELHAEDVNYELESGYEWIEGESWRIDWGGAWSPVGVDDAGYVYTDSSWRHAAPYAYGVDPAMPTSPTRWKDEELDEDHQLEEDPSPSMRALTRRRRWLRRAVRVEPPIENLPEDESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7M0</accession>
    <name>A8Q7M0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline kinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729540.1">
        <property type="nucleotide sequence ID" value="XM_001729488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7M0"/>
    <dbReference type="FunCoup" id="A8Q7M0">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7M0"/>
    <dbReference type="GeneID" id="5853846"/>
    <dbReference type="KEGG" id="mgl:MGL_3084"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3084"/>
    <dbReference type="InParanoid" id="A8Q7M0"/>
    <dbReference type="OMA" id="PHILGTF"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="79393" checksum="9C89017D9B3A7C6E" modified="2008-01-15" version="1">MHGAYTCACGKSARISTNTFGVTVFVFCSTADTLEFKQKVLTMFSDELGLQGWTQASVAPALFPLQAERLTLKRISGAFTNAVFFVGYNAAPGQSPSPPTLLLRVYGIGSEALLSRRSELLILHTLSSLYEIGPHILGTFANGRVEEFYECEPIGRLGLRDFGSPENEGPACWVARRMREMHEVPLDVMRTVLEQGDLKSPSVGFGRGIENNIMASSHHLSRRRHRPTETSSPAWLSYSYFAHPSPGLFPKQANASTMSFDSLATSYDSMASPIRSILTPNGVPTMPGDSHMSPLALGPSDAPPLSTSPASRAPYPGVWRRLKRWTREASKVVEYVNAFANSPEGHAVCEAYGVGPLPVTLDTPRPSKVALAEELRATRYLFQDMMRCLLAVDLPMLCFEISAYKQYVRAWERAEGKSRRVFCHNDSQYGNLLLLRLNERGELPAMASGMPRDEPVSFGKPPRDASPYLSSRSRSRSRSRSHTKEPHQRLVVIDFEYSMPNPRAFDIANHFHEWRADYVHPTLSWSLAHHGAYPTREERQRWLHAYVDQGRRMHKRGHSPSKLLTPEMLPSVSEMALPPSVTSETPGSTQCSPKSLASPRSPHSIQAQIDRLEQEVSVWSPAVHAVWGLWGVVIAGDEISMLLDHMKKYVQSTPQGLVVDVKALDDDAHSKADHSEEFDNLRFALGRFEMFRQELEERGVRPQSQVQLHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7S7</accession>
    <name>A8Q7S7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor eIF4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729563.1">
        <property type="nucleotide sequence ID" value="XM_001729511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7S7"/>
    <dbReference type="STRING" id="425265.A8Q7S7"/>
    <dbReference type="GeneID" id="5853869"/>
    <dbReference type="KEGG" id="mgl:MGL_3107"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3107"/>
    <dbReference type="InParanoid" id="A8Q7S7"/>
    <dbReference type="OMA" id="WVITLRD"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42115" checksum="4509ECA78280DD54" modified="2008-01-15" version="1">MPSLNDIRARLNQRGVDITSSAWSPKKQKNTSSVGSETSLSPTKEKGISKMETLGRAEVEGHMSTQPLEQSKPSKPLQPLHSSETSTSSSASSEPDPTVQRGSGVVADSFARVSVTRTGREAAMEAKHGVKHPLENEWTLYYDLQKLHGSASSDQYEATLKRVGHFTTLESFFDTFATLHRPSRLEKNSNYHFFKNGVKPLWEDPENASGGRWVITLRDRGQTAGSRAGHEALLDRSWMWLVLALIGETLEENDLVTGAVCSLRGKGDRITVWTRRKEPVDEINSLGQRLLELLELQDEPGIQMDFSVNSGSKESQQQSYMRKHLTSHAPSAQKQFLQEPQSRESTLGTWLDTNATLHPADHVRYYAHQLHSNDQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8B8</accession>
    <name>A8Q8B8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729698.1">
        <property type="nucleotide sequence ID" value="XM_001729646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8B8"/>
    <dbReference type="STRING" id="425265.A8Q8B8"/>
    <dbReference type="GeneID" id="5854004"/>
    <dbReference type="KEGG" id="mgl:MGL_3242"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3242"/>
    <dbReference type="InParanoid" id="A8Q8B8"/>
    <dbReference type="OMA" id="DYESPHM"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1133" mass="122874" checksum="9EFF978C9E74B617" modified="2008-01-15" version="1">MLPMVTMPAPSTPLGDYSALRRRFTVQGSPTDGPPGEATESPSRTSSPTSQRRMSNLYRVLQRRPSHSSLNSDQGSAPLPKSRHRVTFRGAGPPNTSSGRDSPLRMVSSAHQDASQIHTQTRSRSPWRVASPTMPSSSRLRNYNPFARTKPSAGQEDDIFHDAISDNQTRPSSPFMSVTRPHTGMGMHPSDLRRYVYDTSPSMPFVDARVRSSASAPTSMTQHYLSNNVVLVVEPAHCVLNMFGALQVTGNYSLSGMVRVSLPHSMDNCRAVDVQSLQVSFTGYSVYIDSSGRFSSVRLCDLKQELVPTRATLQLPPDGAPMYECEFDMFVPGWLPASFSTRSVCTFYNLDAEATLCDVLSQDLTSATTAIDATTLTPAFSTGSRRVSKPIHVHSVPNLVVIQRSREVVPIPVAQTAAFLGPDVPITSNPFRRETNPFRHLLRAEGPEPPFATSSSTSSSSISATTPPQALTANLPPSSDQSDGGRESTSLPTPTPSRTQRMNRAPLRHHTHIAKLHMPTPVTINGTTHTSLPVKLCLSVPAYSSTHATTREEQPPLIFGLQAELDSLWQQAKAWCDVRICEMEAVCVQMEKYSSSLSRSYCTAFSLDVNETTQIPSSMLPFFDDVPIHAGVCTPQSSMVAQPNRMPQPYSRALVENRVRLEQTGHQPSERQNTIERLRAYTVGPLPTMRERQAKDERRAAKDDKSQASSTPRRRRTVTNALSRLSMFSPQRDSAAGSGGSSTTHTSNYGNGAGTGSHGGLSSILHGASSSADDGAHGTTLDTGGGSTGNATENTKASYVFDGEDGCGLALSRKRVRLSFSLPLVPSHGFMALKYNTPQLLPDYESPHMRIRHKLKVKVRFGFGSSLIGTPVGMQSVVMSVPVRFSEAPPKEALSQAPPLVLPKQARTYVPSNGAPNAALPPSYVHASYSTIEGAQGHSSYLPAYTQLFREDGSRLEDDAEVLPPYPDQPPIPVAADQHMFAAQLAAALYVVPERDREAKTPAAISMLDAFNAEDQELYEMAQEVDDEMMDERLANDEVPFEDDDDMTAARTARSGADHDGGAGSPLLEMQATNDSTIPRAMDMAASPMMMVGSPASLHDVAHITHASTYTLMDQAHTVSPSPPLVQPRTMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8D1</accession>
    <name>A8Q8D1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729705.1">
        <property type="nucleotide sequence ID" value="XM_001729653.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8D1"/>
    <dbReference type="GeneID" id="5854011"/>
    <dbReference type="KEGG" id="mgl:MGL_3249"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3249"/>
    <dbReference type="InParanoid" id="A8Q8D1"/>
    <dbReference type="OMA" id="CRNHASS"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="438"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="646"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1127"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="705"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="841"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1135"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1184"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1219"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1424" mass="153973" checksum="0D8745DEB2183935" modified="2008-01-15" version="1">MPPQQAQRMGTRFLHQLTNLGGSGNSSHDTPPQPAGNGSSSPVKNQLASFFQKGPNSSGSTPNYPQQQPEISAPTRAMGAHNAFDSAEDPSLRFGEAFSDGISPNGTYMRRAFGNDELADPSGVQAGRFGPMHSLGQVGQNAMLQQPPQQPQFHPHLQQHLQHHMQQQQQQQFHLQQPPSSVDHMMDMNAGRFMPQHNQPQPMRVSTGPHNMPFASQSAPQHARDMFDSNAVLQDGQPKPTTQPPDMVSHMNTNLSSNAGQVGQGSMMHSIPTAQMPLMQPPSFGTTTDASTSKPVFAMSNKPHEGVTTPSAEDHKMLGVPSSAHHEANTDDGGTPLRTVNQWSHTSPTKRMDPAEIDHLSRSYYTELLNFFRTQSIRTSLLTPSRSSAREKLTRLNKQQFAELSTDVHDELRRRQDELQEMPFLQGRDDFHPKRNQARQKLATLPKTRFRDLASDVFFELERRYPELPQELRYESLEDLMGAREGHSRNSSLISKAPAGVNTGAMPGAVPGATNDVKPPYSLVSSTPGAGTRGMEQAPAPVPVPVRVSVPPPASSQSANMPPPPATSGPMPGPTSGSTFGAVSTAPVLGAGSAPSTAAPLSDRQQADPYGTRPLSSSRMSTNLAQQQLTDLMADAQQMSSAEMFAPAHSAAVEEQDPRSLQAAARTSSSDRDSMIPSASAAAAAAATLPAASGAAAPAIDPAEIRAYEEQVGLLQKQVQLLEEQEHVLRAQGTEHDRLVEQLRSQNNALETRLTSLEHELEAHETVARDLRSESDRRQVALDDKEAELLQHRADLDVLRSQYNELNLAHAARSADAESETHWKRQLEVMQRETLEQQQIVQDLRGEVATLLEELRRLSARNDAMTADKESDVAIIRDLHQQMSTYKRRYESAKGELRMVQSTAQLWAQPHVDEWRYVSPNGAVADTNLRSFQSAIDELLSSARSSAPSNVLIAMKTVVLSTTLVTDDVAKYEMQPNNEMASLSPQQREDVETLKVSISDALSNLMNACRNHASSQGLAPVSLIDAAATHVALAVVELIKLLKLRRVPRPDEDDLSFDSMADSGPALGGGSTTPNGLKPLHTRNAASPSHLLSRGTPSRGAGITSPTSLRSLSYSNSNLDARARALDVPTGTPNASHQQQQHGQTTSAPGAGATSSGAADVAASTPTPRPSAVPPRLPNREMSSEPSASTTPQESSRARLPSTETATRPQSPHVPRPPSATSTWRGSSTDQPMPNNGNLQQSTSPESVSTPASSRTPSQSHSHMQQQTRPASQLAVPMSQQREDEDAEDELENWGELRNYIEVQTEAIVHSIQSLLSALREGAQGVQLNENLTQITTIVSSIVAISRDHLPQATSRHGAIATEAERIFAELTDNCDRLSDMQSNTSFDRSAKSVMASASYGVAKGLKALNELLNAADEAPLAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8V5</accession>
    <name>A8Q8V5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729307.1">
        <property type="nucleotide sequence ID" value="XM_001729255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8V5"/>
    <dbReference type="STRING" id="425265.A8Q8V5"/>
    <dbReference type="ESTHER" id="malgo-a8q8v5">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="GeneID" id="5853619"/>
    <dbReference type="KEGG" id="mgl:MGL_3342"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3342"/>
    <dbReference type="InParanoid" id="A8Q8V5"/>
    <dbReference type="OMA" id="YEVYPIC"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="5">
        <location>
            <begin position="101"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="519" mass="58152" checksum="AF8CD74C211CE858" modified="2008-01-15" version="1">MAGDSSTTKSNPVVNFVVALWKVLWEIWIEPFLQFIHVYEPADRTYGRSEVPFSKMEQRLHENPDVTVSFYKAMMPNGKDFVWYQVWEDKLAMRSTGRVADMVFCHGTGVHSGTLASHSRRYLDAGYRLIVPDLPSHGYSTGRHVYQPTMKGYTDGVYQAIHDVARRDDEAEGRKIPKQNRRRTFLLGLSFGGLVALLYPIYYPASARNDTTDMDEIPVDGVVAVGPILHFNPKDVKVSPVVRFIVTIIRFLNAGRLELYVPHKQAVDKDPKVYKQLVDQDMRSHRGAFRVGHLLCVRRGIADVQELADKFTVPVYIQHGLQDRVVSVTSSTTWLEKIGSDDIKMSVYPVCQHVIYRKAKTEEEDLAGRVCVLEDNVAWMNARCPGIGHIERGVSFSSDHSDMSKDASQRTLAYSGFSSGLMTPSEAALSSMGQPNIVEDTIQSLTDKLGAFDQEGAKSTGVDNDASSTSQSLSNRLAKDSAKQPITPVSGPDDSVEHRVYRGNWTLPQEMRPYDILID</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q919</accession>
    <name>A8Q919_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729357.1">
        <property type="nucleotide sequence ID" value="XM_001729305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q919"/>
    <dbReference type="STRING" id="425265.A8Q919"/>
    <dbReference type="GeneID" id="5853664"/>
    <dbReference type="KEGG" id="mgl:MGL_3392"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3392"/>
    <dbReference type="InParanoid" id="A8Q919"/>
    <dbReference type="OMA" id="TELAFLC"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="169" mass="19209" checksum="F5043C33C410BD92" modified="2008-01-15" version="1">MFLMHRAPDTALFNAIRAPCCRKFFDCPECHAETQTHPLAKTTELAFLCKKCRRAFRKDMAVYEQADEYCPHCDNHYVIEAKTPQLMLSVEGDDGRVDPSIIRDDRISSKGVESSHVNKIDEGGYQAAAIEFQRQLAQGRRNGAELSSSSRTSDIPSMTDFRDDELDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9D6</accession>
    <name>A8Q9D6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729427.1">
        <property type="nucleotide sequence ID" value="XM_001729375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9D6"/>
    <dbReference type="STRING" id="425265.A8Q9D6"/>
    <dbReference type="GeneID" id="5853734"/>
    <dbReference type="KEGG" id="mgl:MGL_3462"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3462"/>
    <dbReference type="InParanoid" id="A8Q9D6"/>
    <dbReference type="OMA" id="CHTETPI"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="214" mass="22780" checksum="670ABEC6AA13624C" modified="2008-01-15" version="1">MSMGFLLPPQSSGSNADTPVVWRGLMVMKAVQQLLFDVDWRAGMTPDSDPMAPGHESLDVLVIDMPPGTGDVALSLSQLVLVDGAVIVSTPQEVALVDARKGITMFQKVQVPILGLVLNMAHFLAPDTGKTYPIFGSAQSFEALAHRLNVPVLGRIPLEMHMCYGSDQGIPEVLRPHSDAPGSAQASLLSMARRTWAQLAKADNAKHAPSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9P1</accession>
    <name>A8Q9P1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729489.1">
        <property type="nucleotide sequence ID" value="XM_001729437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9P1"/>
    <dbReference type="STRING" id="425265.A8Q9P1"/>
    <dbReference type="GeneID" id="5853796"/>
    <dbReference type="KEGG" id="mgl:MGL_3524"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3524"/>
    <dbReference type="InParanoid" id="A8Q9P1"/>
    <dbReference type="OMA" id="TESAPIN"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="401" mass="42318" checksum="DA4132AAF91A60D1" modified="2008-01-15" version="1">MSSPSLRAVCLNTPPACATGSFVPAPSGQSRSLVSSVLLTAEGYESRQVTELRALLRQRGLATSGRKAELVQRLKQNDMVRAGSTLASSTSSTEKTRRSTRMPRTAAPPAHSLSMMPISARTKTTARGKKGSDAANAAEKTMPSMSIEPGTVVSGTTVLNSDGATVSSPKKADSGHATVPGNPESSSARGSEPVFNVTIPFEEPMQPEPQYIPSIHMLENPAYNSKDSFHSDWHIPHVPRVHNVGQMAEVSHNASISISEQEGAPVASGGILTDLMSDYLPNKVQRQVQQSVASTQQATRNFFSDLVTDVSRAMPMDPSVMPSKSTARPSTRRALNDGERKGLWVLGGIVASGFFLGGLHSSDKKQAKVSSATANASDASGYQAPSFQQGGGIVGACERKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9Y3</accession>
    <name>A8Q9Y3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical histidine acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729100.1">
        <property type="nucleotide sequence ID" value="XM_001729048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9Y3"/>
    <dbReference type="GeneID" id="5853407"/>
    <dbReference type="KEGG" id="mgl:MGL_3567"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3567"/>
    <dbReference type="InParanoid" id="A8Q9Y3"/>
    <dbReference type="OMA" id="YIWNAAE"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF195">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725208" evidence="2">
        <location>
            <begin position="20"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="464" mass="52727" checksum="8891E03F0D792D11" modified="2008-01-15" version="1">MNFLLQLVSLALIASCGLSAKPIDSFYPNLSNPSSIVNPKYDPLMKGGKRETRNGTSDGSYSYCSMPHPNVAFYEEPTPIKNGSIHANLTKLLYIQRHQKRTMYHVFPNGEKEIYFCNDIRPHVYVAPSADGEIQPMPVFAQTYVDFLNPLYRAFTNSTCQFPQITLGGFLDGVQHGKELRELYGDKYHVIPDQPDPHRVWMRSSTAALTQDSASGVLRGIWPDVQGPLPLFQQADQVDTHEPSCDRADSLLSAAKKTDVWKKHLSVTKHLRKELEAILQTNVSDWQSDWDHYNDNFQARLCNGYQLPCSNNDPTKCVTKDQARKVFAAGDWEYNYYWVARDNVTEAIRLTSGLYIKDLIEQLKEMNSGNSDLQYVHHFMHDGDIGPLAGSLGIKSLRWPGMASNIAIELWTANDGKNYVRALYSGHTIHSRYGNMEWMPFDDFISYWSKFVPANFVSQCKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAD8</accession>
    <name>A8QAD8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3697</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729230.1">
        <property type="nucleotide sequence ID" value="XM_001729178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAD8"/>
    <dbReference type="FunCoup" id="A8QAD8">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAD8"/>
    <dbReference type="GeneID" id="5853536"/>
    <dbReference type="KEGG" id="mgl:MGL_3697"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3697"/>
    <dbReference type="InParanoid" id="A8QAD8"/>
    <dbReference type="OMA" id="WNPNKSK"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="312" mass="32745" checksum="F607EE033B4EF08E" modified="2008-01-15" version="1">MAFGARGGRGGPPGRGRGGPPGRGGMRGGGRGGRGGARGGGRGGRGGGRGGGRGGRGGAKGGRGGAKGGSNVIVKPHRHEGVFVAEGKEHLLVTKNLVPGESVYGEKRISVETPGTNDDGSATMNKTEYRVWNPFRSKLAAGVLGGLDNIHIKPGAKVLYLGAASGTSVSHVADVVGPDGIVYAVEFSHRSGRDLINMAKKRTNVIPIIEDARHPAKYRMLVGSVDVIFADVAQPDQARIVAFNAEYFLKNGGHVVISIKASCIDSTAQPEAVFAEEVNKLKKSSFRPREQLTLEPYERDHAMLVAQYQRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAF8</accession>
    <name>A8QAF8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729250.1">
        <property type="nucleotide sequence ID" value="XM_001729198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAF8"/>
    <dbReference type="STRING" id="425265.A8QAF8"/>
    <dbReference type="GeneID" id="5853556"/>
    <dbReference type="KEGG" id="mgl:MGL_3717"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3717"/>
    <dbReference type="InParanoid" id="A8QAF8"/>
    <dbReference type="OMA" id="ESEMAGW"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001494">
        <property type="entry name" value="Pachytene checkpoint component Pch2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="165"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="352" mass="38996" checksum="94C7EE41F6633127" modified="2008-01-15" version="1">MSSCTSSLVHVEVRLRSDIEIFDTADIEAAVRRFIESDPHAPIECESEMAGWQQADTFLAEHVDRIYVGESDPPSASVLVHEVDMELHVYQPCPHDNVDEFGVGDADAAADNAVAATLSELPNHALDGLWRTLVYSDHVKEHLLHYIYSTLEFSDAGIDFHVIAWNRVVLLHGPPGTGKTSLCRALAQKLAIRLQKRYSHVKLVDINSHSLFSKWFSESGKLVHRLFDMVTELVEDEAGFVVVLIDEVESVTKARNSLVAGTEPSDSIRVVNALLTELDKLKYRRNVLIMATSNLSDSIDSAFLDRADIRQYIGLPGTEAGYSMLRACVLELIRVGLGAPGAVSFIRRHGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAJ1</accession>
    <name>A8QAJ1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Delta(14)-sterol reductase ERG24</fullName>
            <ecNumber evidence="3">1.3.1.70</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">C-14 sterol reductase ERG24</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol C14-reductase ERG24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MGL_3750</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:18563"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.70" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729283.1">
        <property type="nucleotide sequence ID" value="XM_001729231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAJ1"/>
    <dbReference type="FunCoup" id="A8QAJ1">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAJ1"/>
    <dbReference type="GeneID" id="5853589"/>
    <dbReference type="KEGG" id="mgl:MGL_3750"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3750"/>
    <dbReference type="InParanoid" id="A8QAJ1"/>
    <dbReference type="OMA" id="PNYMGDL"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000009">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP42069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="437" mass="49684" checksum="98AD30CB4562E53A" modified="2008-01-15" version="1">MAMSSTNKKANRELLAPHSHELEFGGVFGALFVTVSVPLTMYYLTFGCNADMGCSAWLPLSNASGFWSYAKKQFLDSFQDPVAWGLYYSWYLYCVVAWYVIPGDWVQGLPLRTGEKLSYKINALKTGALALGIALAIIAIKGPASFTLLYDHFPGLLSAAFVNSIVQAIYVYVGSFRGDKLLALGGNSGNVLFDWFIGRELNPRIGSFDIKTFNELRPGLLLWVLIDISCACHQWTTFGRLSDSMALVTLFHAWYTIDSLIHESTIFSQMDITTDGFGFMLSVGDLAWLPFTYCLQARYLAFHPVDLGLLGILAVLAVQFVGYYIFRTANVEKNEFRHGRNPKRLDFMTTSSGRKLLTSGWWGRSRHPNYFGDWIMAWAWCLPCGFSTPIPYFYVIYFAVLLWHRQLRDDDACRKKYGNDWDVYCRLVPYRIIPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAM6</accession>
    <name>A8QAM6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728997.1">
        <property type="nucleotide sequence ID" value="XM_001728945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAM6"/>
    <dbReference type="STRING" id="425265.A8QAM6"/>
    <dbReference type="GeneID" id="5853304"/>
    <dbReference type="KEGG" id="mgl:MGL_3785"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3785"/>
    <dbReference type="InParanoid" id="A8QAM6"/>
    <dbReference type="OMA" id="CQNESEG"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="147"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="303" mass="33689" checksum="442DAE55856F5BD7" modified="2008-01-15" version="1">MKSSSEAGLFRASLFDSAPEGAESTDDQGRVDRQQQQKTSEGHESEHEVSNDEDEDDYDDEERLAEEMSIKASLEEQHQHLQNHWSQHASHYTTPLYLNTIPEPENEPESEAQDQALQESALSTSHVPVIGSGEGEVYEQMKIDGLDHVFERFTRRLGSEARQVVRYEFGGVPIPFSGKGSLFKRLWPNGLHAGCDSSSVPACEYCGAPRVFELQLMPNLANLLRAEKLSDAAESNGENSSNQEAQRQAEIASLFGLESAVTNMRTGIAWSTAIVYVCSRDCCQNESEGYAEEWVGLQHETDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAR5</accession>
    <name>A8QAR5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DSC E3 ubiquitin ligase complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729028.1">
        <property type="nucleotide sequence ID" value="XM_001728976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAR5"/>
    <dbReference type="GeneID" id="5853335"/>
    <dbReference type="KEGG" id="mgl:MGL_3816"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3816"/>
    <dbReference type="InParanoid" id="A8QAR5"/>
    <dbReference type="OMA" id="FLQCSIG"/>
    <dbReference type="OrthoDB" id="2556122at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="DSC E3 ubiquitin ligase complex subunit 3 C-terminal" evidence="3">
        <location>
            <begin position="159"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="466" mass="52313" checksum="C1DF93005343D305" modified="2008-01-15" version="1">MQGKKIRLIYFGRVLPQGVRLASWLDALSIPDATSASGGGGSTKRESGLEDGVSVQDCLDSLRDDDPLPYERILVERVPQEDGMYTLRRPANISSHVTNSKSHGKQRDLELDHVDRTMKVCAVCLPTIFLQCSIGGQLDAHEPNASEAGPSVSTTNEPRGFDRLRYTAGMSDMDIQLMREQFHRQSGLLGIRSGDVLRQREEDNMVYAMEDQWIDNMGQDPVQRQVSSVWKKGMWGLLIGFLFPLLPLFFVYDSPMIPWPRRSALRLAHQAQVLQHTRELESLLAQLSERLDARSGELDTAQRARIDNVRRSVLMPLDQFRQSVVEREATRMDQHDSGTGFNGNGLRTHTTANNAEPREGRQAHDNDGNTNDNSGSNWRGNGNGEDDEDDDDEVNESDHVVREGAADPASWRSPLERLGVRAPRVNHYVVFSPVTLFCIMIGFLVKYVHPHNANASVLVCIIRFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAT4</accession>
    <name>A8QAT4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729038.1">
        <property type="nucleotide sequence ID" value="XM_001728986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAT4"/>
    <dbReference type="FunCoup" id="A8QAT4">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAT4"/>
    <dbReference type="GeneID" id="5853345"/>
    <dbReference type="KEGG" id="mgl:MGL_3826"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3826"/>
    <dbReference type="InParanoid" id="A8QAT4"/>
    <dbReference type="OMA" id="EFFGCIN"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="65"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="384" mass="41782" checksum="BF4E83ED5B994258" modified="2008-01-15" version="1">MKWMICQVRVSYNSLIANRSAAPRDNSAGFTDGAAPSIRAMGRSRFDGAPPPLREEPPLPTQPPFTAFVVNLSFESDEAAVRAFFEPMNPISVRLVSGHDGRPRGYGYVEFQTLDELKDALTFTGKPLDNRNVRVSVAEPSSRAARSAAADDATQWRRSTPLPSSDTRRGPFGGFDGPSGFDNMSISSDGARTGFGGKFAPSNDMPRRRGPMEPIEPSAGDVASDWRTGKPVTSKSSRFGFGDHEGGAASRGGFGQRYDDADFSAWRSKKPSADGGAAPLPERRKLELKPRSAAASNEASQSTSSKPNPFGAAKPVDVNERQRQIDEKIREQDRVRREELMKEDERKKSKGFFGKPRASDAWSENTPDKITSGDAQSKNEESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB36</accession>
    <name>A8QB36_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729091.1">
        <property type="nucleotide sequence ID" value="XM_001729039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB36"/>
    <dbReference type="GeneID" id="5853398"/>
    <dbReference type="KEGG" id="mgl:MGL_3879"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3879"/>
    <dbReference type="InParanoid" id="A8QB36"/>
    <dbReference type="OMA" id="RADIAWI"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="44914" checksum="0ACC6F9ACED8AFF0" modified="2008-01-15" version="1">MEKSAHVEEQQVDEPPDGGLVAWTQVLASHLTMFNSWGYMTSFGIFQPYYVKTLNQDPSNISWIGSLEYSCIFFMGFLAGRAADAGYVRTLLFCGFALQILGVFTTSACNTYWQFLLAQGVCQGLGCGLTFTPMVSLVSSYFKKKRVLAICIQASGTSSGGLVFPAIAKTLLPSVGFPWAVRAMGFVIVFNSAIILLLVKPRLPPRKNGRLVELSAFKEPTYLLYTIGIFLALWGNFVAYFYLRAYAKDIVHVSEDVSFNMLLVMNGIGIPGRIIPSLIADRLLGPVNTISIIILLAGVMMSCWITIKHTTSMWIFSVFYGLFSSAIQGLFPAALASLTSDPTKQGLRIGMACSVFSFACLSGSPIAGHLIEIHNGQYLHAQIFGLVNMFCGCAFVVACRTARCGLKIQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBE7</accession>
    <name>A8QBE7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728911.1">
        <property type="nucleotide sequence ID" value="XM_001728859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBE7"/>
    <dbReference type="GeneID" id="5853217"/>
    <dbReference type="KEGG" id="mgl:MGL_3905"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3905"/>
    <dbReference type="InParanoid" id="A8QBE7"/>
    <dbReference type="OMA" id="RECARWT"/>
    <dbReference type="OrthoDB" id="3351202at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP41697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="67160" checksum="52DFDB36F7C84764" modified="2008-01-15" version="1">MGHTNVSEEVHALSLRSATYLGLYSLEHASLNHAHRLSQEYVSDVFDALHSASKRWKEHLNSTVTVNKNTSTPAQIRELATQALELSFATQGLREASSSAVYIPPPIPPKLWTGALSRASEPSTDHRLAVETLHTLCQVIIPTASDMHLECFQERIDMQDTNSSLDKIHTLTCGGRIIVLDIELDLASQTSSSWIPHVSLQLSFASANGAQSPTSKDSGLAEVVRLPLQQLARIMFGLPVDHQLLQRFCKGARLDSSYAQTAALWHSFTSTLASLACIDGLHAFSPYGDTLDAFHVLEQLGSAALHVCSVEADELAQLHAQSVDPARPLHDQPSITRLLHRYGHGLALHHYHTPYLCIAFTPVHSATVRIAPSAVPFAPDAKPACTLVSSARMPQMVYEPFQARSADCDQARPLAFIAHIKPALLVPHRVARHVYLALGLARHHLSTSKPRRPIHGYVAQLVRTSHRFCASLRDEECRSITSLPFQSLAHLYAALEILQEHAHWAALLASAQDDPSGESGLVTTLQLESDTEPSSSWLRLSTLVSEQDMVINAQLRHRKGWQLQAQAVSLKQRISTNLPDDKAHTFAESLNMCAQLGGLVNDLLAWTRTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBG8</accession>
    <name>A8QBG8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728916.1">
        <property type="nucleotide sequence ID" value="XM_001728864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBG8"/>
    <dbReference type="FunCoup" id="A8QBG8">
        <property type="interactions" value="665"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBG8"/>
    <dbReference type="GeneID" id="5853222"/>
    <dbReference type="KEGG" id="mgl:MGL_3910"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3910"/>
    <dbReference type="InParanoid" id="A8QBG8"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="535" mass="57913" checksum="B08C99114409FCE4" modified="2008-01-15" version="1">MSAPVASRQSQPGFRAFKNSDKPDEVRRSNLSAAKAVSDAIRTSLGPKGMDKMIQTSSGEVVITNDGATILKHMAVVHPAARMLVDLSQAQDVEAGDGTTSVVVIAGSLLGAAEKLLTKGIHPTVIAESFQHAATKAVEYLNEISTPVNLNDRDSLLRAATTSLSSKVVSQYSSVLAPIAVDSVLRIVDPKKGEGESVDLRDIRIVKKVGGTIDDTELVDGLVLEQNVVTSSGGPSRVEKAKIAVCQFQLSSPKPDMDNQIVVNDYRQMDKILKEERQYLLNMCKKIKKTGCNVLLMQKSILRDAVNELALHFLAKLKIMVIKDIERDEIEFLCKSLGTSPITDIEAFTEDKLASADLVDEVQHSGARVVKVSKIKNPGRTVSVLCTGSNSLVLEESERSLHDALCVVRCLVKKRALIAGGGAPEVHMSRMLAQHAQTLQSLEAYSFQAFAEALEVIPTTLAENAGLNPITIVTELRNRHAMGEKTAGINVRKGMITNILEENVLQPLLVSTSALELATETVALLLRIDDYHLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBI5</accession>
    <name>A8QBI5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728920.1">
        <property type="nucleotide sequence ID" value="XM_001728868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBI5"/>
    <dbReference type="FunCoup" id="A8QBI5">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBI5"/>
    <dbReference type="GeneID" id="5853226"/>
    <dbReference type="KEGG" id="mgl:MGL_3914"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3914"/>
    <dbReference type="InParanoid" id="A8QBI5"/>
    <dbReference type="OMA" id="CAPWIFR"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="162"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="696" mass="76407" checksum="75DFD65DE0D24998" modified="2008-01-15" version="1">MRANANAQGSNTGADPFSSLSPEHEKVLKDLWARLLDVFAQNHERSDELDRLGGPHTARTGQELTANSDSKDSGKKHKESQQVQEYRAVNDAIRKYGGRHLQQMFWRTVMMDAPDHLMLRFLRARDFNVNSALGMLVGALQFRLDVGVDELIYQGELGLRNVKGFLEQYRNRISYIEGSTDQHEMPIYFIHVARHFTNAQPLETMQKFLILALENTRLLCTPPMEKSILVFDLQGFGLKNADWHTIFFIVKCLEAYYPESIQRLYIHCAPWIFRGIWSALQPMLNANVQSKIKFTTSVKELEETIPRSHLRADMGGTIQGEWKYVEPEENENDLLKDTETRDLIQKEFICLQDKFEEATRHWLDGAPDASHRRDVLTRQLRLKYYQLAPYVRARTVYHRKGILRNDFLIHWEYPQMNGNILTQDVNVSDNVPALIQWLREHNEDTLENSIGGTKSPCAVAPHSYSALDAVHAIKADQGAGEHARTAENSASASDGNRKDSQNDATASASSAGAAGAAGMGNLAHNEADTPDSHKRNSIHRKPVPAMNQGTEETTSSEHAQSHTVQSPYQPLDGSRGQTGLHDDVRQLNLNAEHEVGVQSASDEASSVPLAKRNDLEPSDASASRESVASSPTGAGAMAATAKVAAAATVGAAAGATTAGAGAAAVAGASLVAGTLGAVGTVGTTGAAMWRDNNQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBN3</accession>
    <name>A8QBN3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TAP42-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728932.1">
        <property type="nucleotide sequence ID" value="XM_001728880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBN3"/>
    <dbReference type="STRING" id="425265.A8QBN3"/>
    <dbReference type="GeneID" id="5853238"/>
    <dbReference type="KEGG" id="mgl:MGL_3926"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3926"/>
    <dbReference type="InParanoid" id="A8QBN3"/>
    <dbReference type="OMA" id="ASKIHRT"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46560" checksum="169B6D4A6918B863" modified="2008-01-15" version="1">MMADDPESSDASLTLKLDSAFRLAEKRSGDDASVLRLLREVAHAADAMSIISANDLKDDISTPSLRLFLIPSLQAELETCARIESQTDRLQLRKSHVQAAIGAARVFFTIARKHEILPTSLTRLLQPYLNPETPSKMLSPAEKRMNKIQQYKLEKAVQAQLSVFRDAYRSRKAPKSTQEAPSNVYYDLLVIQTKVKTNASDPALDGEDDGDDDDDDDGTDLDRVVTPSYEVLPVSGLRGYLCLLIVLHALRTANTIESATQELELLSHAPPPSLTDAHGHSAEPDKTWRLDTGWTSASAANGPLLSETGRPLRPFTITASSTATKREQLASEVFRPSHRLPTMSIDEYLEEEARRGNIIQGGGHSQSQQPTPREQRAERAENDGTRDADDAEEEARQEAIYWDSFKESHRRGEGNTMNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBW4</accession>
    <name>A8QBW4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3947</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728953.1">
        <property type="nucleotide sequence ID" value="XM_001728901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBW4"/>
    <dbReference type="FunCoup" id="A8QBW4">
        <property type="interactions" value="938"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBW4"/>
    <dbReference type="GeneID" id="5853259"/>
    <dbReference type="KEGG" id="mgl:MGL_3947"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3947"/>
    <dbReference type="InParanoid" id="A8QBW4"/>
    <dbReference type="OMA" id="QRCYHEE"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="569" mass="64995" checksum="F58C82B50CDAE77F" modified="2008-01-15" version="1">MADTSVYESTRMTHEEIEQYENALVDTLNNPPKASSHRLQMQWQLAASQLLDEIVNRYQTLSELYNDANEERSNEWENLASQMGSDDENGAMSEFYKRLGNLQDYYRKYPERAIALETSATPSILGTHDTSLFDFSLMERDFSGEEMGGRFLDLYVQYEMYLNLKDVSPMSYLEYITRLDCMVGDSSTVPVATKRSEAYRTYLTNLSQYLSSFLHKTRPLEDVDAIEEACLAKFDSDWESGSVIGWESKETTLYGPHTTKTEQGEGIWCDACQRSYAKQTVYDAHLTSARHMKAMHRIEKGEPTLQSQQTREKNAAELGQKKRSLRAKLIARDEVLIQALAKELSSVRDETRSNVERKASLTEREREEEAEALDAEMDEAVETGGLGYEDVPEDGEGGAPGEKMYNPLKLPVGWDGKPIPFWMYKLHGLRVEYKCEICSDFVYKGRKVFEKHFQESRHAFGMRALGLPNTPQFRDVTRIQDAYALADKLRRQKRLQNVEEDDTVEVEDDQGNVSYIQTAHARHIPEKHTICSGAKACFDGMGMTGLIVDRSFTRSGCVSMTYNIFQFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC64</accession>
    <name>A8QC64_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3976</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728809.1">
        <property type="nucleotide sequence ID" value="XM_001728757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC64"/>
    <dbReference type="FunCoup" id="A8QC64">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QC64"/>
    <dbReference type="GeneID" id="5853115"/>
    <dbReference type="KEGG" id="mgl:MGL_3976"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3976"/>
    <dbReference type="InParanoid" id="A8QC64"/>
    <dbReference type="OMA" id="EQTMPVI"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="174" mass="19416" checksum="2F1667E30CFC5852" modified="2008-01-15" version="1">MGTPEYDASKVVVVFVLGGPGAGKGTHCAHLVRDYGFVHLSAGDLLRAEQARPGSQYGQMIAEYIKEGKIVPMEVTISLLRNAIQLAIEEHDQSTSEGWGNGKGRFLIDGFPRKLDQSYKFEESVCPAQLVLFLECSEEIMLKRLLQRGETSGRTDDNIDSIKKRFRMLNVYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC73</accession>
    <name>A8QC73_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728811.1">
        <property type="nucleotide sequence ID" value="XM_001728759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC73"/>
    <dbReference type="FunCoup" id="A8QC73">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QC73"/>
    <dbReference type="GeneID" id="5853117"/>
    <dbReference type="KEGG" id="mgl:MGL_3978"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3978"/>
    <dbReference type="InParanoid" id="A8QC73"/>
    <dbReference type="OMA" id="KMAKMNQ"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="242" mass="27182" checksum="3185F137A1F6C15D" modified="2008-01-15" version="1">MPLWEALFGRSVTPAERLRQHLRSLQRAQRELERERVKLEAQEKKLVTDIKRHARQGQMPACKVMARDLVRTRRSIHKFYQMSTQLQAVGLRMQTLRSTQQMAEAMRGASRTLGSMNKSMNIMAVQKILQEFERESTSMDMKDEIMNDTVEDAIGTQEDEMGEGIGEGEESDAILREVLDEIGLDMHQQLRQAPEGALAAPLMTSTPSRVAIGESAGPGGSSSAANEDMALQERLDRLRKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDA9</accession>
    <name>A8QDA9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728695.1">
        <property type="nucleotide sequence ID" value="XM_001728643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDA9"/>
    <dbReference type="STRING" id="425265.A8QDA9"/>
    <dbReference type="GeneID" id="5853002"/>
    <dbReference type="KEGG" id="mgl:MGL_4174"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4174"/>
    <dbReference type="InParanoid" id="A8QDA9"/>
    <dbReference type="OMA" id="PSEWSRW"/>
    <dbReference type="OrthoDB" id="3365958at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="371" mass="40460" checksum="94A830598C6A5BEE" modified="2008-01-15" version="1">MDQRGFRQLLASRSHEPRRDESNYAVHNTTDSDGSVSMMQPRSVLLNRSSESRQEQYKQMLGAEEAASGRTKGLDFALLAKQKELMAQSSEPQEVDLDAAFMEGQHTAQANANAEAQAAEYRAKFRKVAAHPEAPDIIYVNGKRMRKKKKKSLDPQPVSEPRHSNAVPDDVPPVDEKQRGEKRASRDERVTAPSSSGIDASQANEPTRASQSAVSTGHMDKSRSGESDDDAADIFDDAGVWNGLSSDDEHTPAPTSTTDKASTSLHGTCTDWFRQGTSTRSDLPAQPSSSDPETDTVPAPDQNGPSVPASTAGPQRLQGLSSSALPSEWSRWLLDREEKKARHASSEQEQAVSAPRKRRRSRKGRGDGDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDB9</accession>
    <name>A8QDB9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728701.1">
        <property type="nucleotide sequence ID" value="XM_001728649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDB9"/>
    <dbReference type="STRING" id="425265.A8QDB9"/>
    <dbReference type="GeneID" id="5852988"/>
    <dbReference type="KEGG" id="mgl:MGL_4180"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4180"/>
    <dbReference type="InParanoid" id="A8QDB9"/>
    <dbReference type="OMA" id="PYYFPSE"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="386" mass="42789" checksum="2A0FA647AE257D81" modified="2008-01-15" version="1">MYNQDSVLYSNEAVRALRLAFKYGINALDSSPYYFPSEFVLGRALRILAPERPRSSYFLITKCGRYGPEKHMFDYSPERVHTSIRKSLERLGTTYLDVALLHDVEFVSDQPAEAVKGSNAGWLEACAVGTAQERVWSPEEAQKVLGIASEDASQIRGPGDERVLNAVRALFELKDQGLVRQVGISGYPLGELVRIVRLVASHPPYRCLDVVLSYSHHTLHSDLLPAWKDLFAACPPGREATWRAPFVLNASPFSMGLFSDRDPPAWHPADTRLMSAARGALRELQKDAASPCSVVDPSVVMGQTALFRGISGSEAVDSNGVPVLRTLIGMSNVDEVHAAMRIYRVLSQPAVFEREYNQLAKYNDLVRARILEARVADKAWPSPSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDU0</accession>
    <name>A8QDU0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000023">
        <property type="protein sequence ID" value="EDP41423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728637.1">
        <property type="nucleotide sequence ID" value="XM_001728585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDU0"/>
    <dbReference type="FunCoup" id="A8QDU0">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDU0"/>
    <dbReference type="GeneID" id="5852934"/>
    <dbReference type="KEGG" id="mgl:MGL_4236"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4236"/>
    <dbReference type="InParanoid" id="A8QDU0"/>
    <dbReference type="OMA" id="LTLMWAN"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="11"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="359" mass="38421" checksum="D864F8FEA84738BF" modified="2008-01-15" version="1">MTGMEAVIVDGKSAASVKHVEAPKLQPRSILVRVQCIALNPTDWKHLDYYGKAGTTLGSDFMGTVIEKAPDAGTNVKVGDRVAGMVHGAWEVGVGAFAQYVVTLPEYVVAVPDSMSDEEASGLGVAGITAIFGLFQNKHLGLPEPSGTELPPVDPKLKVLVWSGASSVGQFVIQTARAIGAYVIVTASARHLDWLKSLGASELYEYSNSETPKRIAEAHPDLKYAFDTYSMNGSQAACAASMSKTEAGKIVSLLPFDHGTVTEANPMAKCTFLLLYTVSGQRTQIFSADFSEEYCKEDAKYMIRAASGKDGLFYRLLSSGLVKPNRTSPQTGGLSGILSGLDLMRHNKVSGEKLVYKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A8PQX9</accession>
    <name>A8PQX9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732760.1">
        <property type="nucleotide sequence ID" value="XM_001732708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PQX9"/>
    <dbReference type="GeneID" id="5857066"/>
    <dbReference type="KEGG" id="mgl:MGL_0535"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0535"/>
    <dbReference type="InParanoid" id="A8PQX9"/>
    <dbReference type="OrthoDB" id="3349465at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727835" evidence="1">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="230" mass="25960" checksum="728B9F3B36DC3766" modified="2008-01-15" version="1">MFKFIALLASVAIAVSSAAPTKHESIQCKPVGEPLKLFSTGYDSSTTFKIADAPVKGEKYPRLVPVDSTSDTFQRYNCTYPGGKLSRYHYDPDFSDDFYGQLRSTSKKDFCVTAGCSWTHKDSPAWVAAQHKASCEFDDKHCTPEVCAAKLEPCATEASDRLRRQWFDFFTFEKDSVPRMQLLGNELDEQAQVLPFTKSYAVFGPAMGKHWYSEAHPYLGKKEYEGFKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR03</accession>
    <name>A8PR03_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732784.1">
        <property type="nucleotide sequence ID" value="XM_001732732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR03"/>
    <dbReference type="STRING" id="425265.A8PR03"/>
    <dbReference type="GeneID" id="5857090"/>
    <dbReference type="KEGG" id="mgl:MGL_0559"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0559"/>
    <dbReference type="InParanoid" id="A8PR03"/>
    <dbReference type="OMA" id="CIANTPH"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="321" mass="35844" checksum="B1A6C7778B9C69B2" modified="2008-01-15" version="1">MFSGPHPLRLQSLQFVPESSVPLIRTTADEANSMSLLWENVLDALDDDVEANEDTDRSSSNEDPLSSSSSSYPSSRNHVYRLGIFQPAILLQIVQGIIQRLFQSVVLLHQHTWLSLSPNLREGSAILVQRVITTAYLQAPHTESLHAVPLTWRELFFWHATLGLALISLAVHFHTFVVVSSVGAFHFGTPFVAVGAYPLVSDAVRCTVVWESVSFVGVLLLAMILWGIGRAFIMIWGSLLRVSNWCIANTPHIVVDWVDTTMQANTATQQGSFVAAATAVVWRPVAWFTWFIERVVHGHAAQREELREDPRWVWMLAHAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR18</accession>
    <name>A8PR18_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732799.1">
        <property type="nucleotide sequence ID" value="XM_001732747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR18"/>
    <dbReference type="STRING" id="425265.A8PR18"/>
    <dbReference type="GeneID" id="5857105"/>
    <dbReference type="KEGG" id="mgl:MGL_0574"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0574"/>
    <dbReference type="InParanoid" id="A8PR18"/>
    <dbReference type="OMA" id="WIPVFAD"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="300" mass="32693" checksum="251FA5B07312214C" modified="2008-01-15" version="1">MSAADSSIERRMRRVRHIVVVLSGKGGVGKSSVAAQLALSLSYAAKSDTPDPGAQKRLRVGLLDIDLTGPSIPRMLGVDGQAVHQSSDGWVPVYTDETQCLGVMSVGFLLRSKNDSVVWRGPKKQGMINQFLRDVRWGDLDYLIIDTPPGTSDEHISLMEAIHPYAPKAVLVTTPQAVALSDNLRSLDFTRKVGLPVVGLIENMSGYVCPHCAECTNVWGKGGGESLADKQGIPFLGRVPIDPALVRLLDDAREEAEHAATDDQHALTYATVRRYRASSTYPIFQHITQAVRHHTQDTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PR40</accession>
    <name>A8PR40_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732821.1">
        <property type="nucleotide sequence ID" value="XM_001732769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PR40"/>
    <dbReference type="FunCoup" id="A8PR40">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PR40"/>
    <dbReference type="GeneID" id="5857127"/>
    <dbReference type="KEGG" id="mgl:MGL_0596"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0596"/>
    <dbReference type="InParanoid" id="A8PR40"/>
    <dbReference type="OMA" id="YNTQNVP"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="62" mass="6959" checksum="846099B47F1826FD" modified="2008-01-15" version="1">MGKVHGSLARAGKVKSQTPKVEKQEKPKVPKGRAKKRILYNRRFVNATVTPGGKRRMNSNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRK5</accession>
    <name>A8PRK5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732298.1">
        <property type="nucleotide sequence ID" value="XM_001732246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRK5"/>
    <dbReference type="STRING" id="425265.A8PRK5"/>
    <dbReference type="GeneID" id="5856604"/>
    <dbReference type="KEGG" id="mgl:MGL_0073"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0073"/>
    <dbReference type="InParanoid" id="A8PRK5"/>
    <dbReference type="OMA" id="MSHANEM"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="614"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="904" mass="97555" checksum="C86AAE3391098C10" modified="2008-01-15" version="1">MDDTNELDFEREVQVLRAHRRLSTSHPAAIDPDFPSVQSPHDSASLSAMNMLERPSTSLSSGVSAISPPLTPKNQSRSFDEKLLSECSPIFGSSNRERYLARRQMRHAQAASAPRTPEESWLGSTPSSSSASHTPHPLPTPPLQPSITSMSHANEMWIPASKHSEVSADEFRTFLKEQAARNVSHYSPWSTVSSSSSPSGSPSRQVPLATSLARRSSSLRRQVRQEDRAPASNSGAGTVHHKRSFSNTESPLEHEHGHEHGQTIIRTESLPSRYSREFTSRSHRKPPPSLAPVDRAELTGQAPNKLSSSHSSSLPAPMPVSLPASHTAEISRAQDSADHEKTLHAMRALLPQKGDLPELPPDATAQVPSHTQSAQAGLFGHSVSMPSLDLAQTPLIPHPPQHQLQLHAPTLAQAQASPLSTLASTGTGAQLIPPPPPPRRQPSDAPDMIRSASGRGRFEEVGRSTTNELDKALAVSASSSRQSDEKNTRFNRKSDEMSRLSLPSLRDRKTFGLSWFGLSKDDDESRVRRKEKEAKEDCASSAPTTTSSSSSRREKDTFLTGLFSKRKGQESYDALRNRARNLFTSSSSSSASSASGQGAASSPSSPGSGTGIQPGAAEFAIVKRYPPPVERALYRLSHVKLSNPRRPLYQQVIVSNFMFWYLSIINSAQARPERPSSTVNGNRGDGLSEYDERNKLYKQGTGPRSPHTGTFLFTLPTKSVSSPMYVPGALVASPWIPPAPQTVWSLAPLTEPPLYGGVHTAPMTPPPTTKDDQFLPNVYSSTALAQESLLPVSDMYMTSPTSTRSGGMPRSARGPLPSVPSTPPPVPASGAGTSAPKPPPRSARRIAHLERISNHAQEVAPSAQHGLRHARSSPSLSKSARVSSHPLPLPPLPVPLPLKNTHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRQ9</accession>
    <name>A8PRQ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732332.1">
        <property type="nucleotide sequence ID" value="XM_001732280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRQ9"/>
    <dbReference type="FunCoup" id="A8PRQ9">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRQ9"/>
    <dbReference type="GeneID" id="5856638"/>
    <dbReference type="KEGG" id="mgl:MGL_0107"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0107"/>
    <dbReference type="InParanoid" id="A8PRQ9"/>
    <dbReference type="OMA" id="QYYELYR"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="10">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="113" mass="12764" checksum="DA4D4D579939100D" modified="2008-01-15" version="1">MTAGRNQYYEFYRQSSIGIQLTDALDELIQSGHINPILAMKVLEQFDKSISETLANNVKSKGNVKGHLHNYRLCDEVWTFIIKNAAFKLDNGEMLSVDKAKIVACKLGENNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS62</accession>
    <name>A8PS62_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732425.1">
        <property type="nucleotide sequence ID" value="XM_001732373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS62"/>
    <dbReference type="STRING" id="425265.A8PS62"/>
    <dbReference type="GeneID" id="5856731"/>
    <dbReference type="KEGG" id="mgl:MGL_0200"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0200"/>
    <dbReference type="InParanoid" id="A8PS62"/>
    <dbReference type="OMA" id="NIWENDF"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727064" description="Phosphatidylinositol-specific phospholipase C X domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39799" checksum="494D6C0979A37623" modified="2008-01-15" version="1">MWIQYASWALLLFTVGVSALPDARLVVKRDTKCNGYSEFCNRKYSNITYMGTHDSFAIGKLGSLGSNQAASLTDQMEDGIRLLQVQTHKSDNSDSSNPSGLNLCHTSCTLKNGGTLESYLKKVGKFLNNNKNEVITLVMTNPDKRPVTDFAKAFENANVKDLTYKPNSQKISKKDWPTLQQMINKNQRLVVFLDDKADFDQVNYILPEFRNIWENDFDQTTSKFNCTPSRYVGDTSTMMYMINHFLDKTIFTDKITSPDTNKIDQTNSVKSILGDANNCAKRHDSYPTFVLVDYYSSGNGSVFEAAAQINNVDYKNKPLAASKDESNNNSAAMAFPDANWLGIALVFVSTITWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSC6</accession>
    <name>A8PSC6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell morphogenesis protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732458.1">
        <property type="nucleotide sequence ID" value="XM_001732406.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PSC6">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSC6"/>
    <dbReference type="GeneID" id="5856764"/>
    <dbReference type="KEGG" id="mgl:MGL_0233"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0233"/>
    <dbReference type="InParanoid" id="A8PSC6"/>
    <dbReference type="OMA" id="MRYLRIT"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="415"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="787"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1452"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1838"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1934"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2288"/>
            <end position="2308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2321"/>
            <end position="2374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2334"/>
            <end position="2343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2398" mass="261449" checksum="EEC1BCC04FAD1071" modified="2008-01-15" version="1">MEGVEDVQVVIPDLEEDDGPFQGLDIPLSHGFHSPSGSQAEPAWPGSSDEPLLLGPASGAGGAPATAPSKSRAGRLRHFRSGSLSTDEVASISTKSSFRFGSSLTNAFSGIDYFQTPNRNSDRSDGLHNFSFPVKKSSFASLRAAIKGQSSAPSTKDSSDLISSPNGPLLDADAQSLGSKRMGRSFPLASDISAVSSGLANVTGMQRPSRWHFKSNSQASTSQDSGSIPMSHSPSRVMRAKHAHCGSQLSENSVDGVLASPSEGSVVATGNDGLSSPVGLGPMDDVDPLSRLSPICDIPPTVSPVAFAMRQILHRFQALADDALHLVLTTPLDCDALLIMFPSAAHHAAWDDVWNSLASMAQHDRQLTTNSLLAWRLDALDQPLMLRPARRRPSDTLSVSSSSSNSHAGDLLRRRRALAATYLTCRALLGTIPPGTNDRMGADMDEDDPAMDEFVTTVFQFLHLCSLDRESERGAQVKLHVSLQQQCFDMVARLIGELSRQCLPALGDQFVSILHQSSAVAVSRDNELLTEAAVLGMRYLRITIYPMDVFEAGAQFVGILARFFAHSHGYRIKRAFARVLHTIIEPVARTASAELHHPAWVQAMSTLMPKAQAMACRSRYCSVAFPLWTAALCASPPDVLLERWYACIEAGWSRLKERPKDAELRLIIYTCASQLFWAYLFRCHEGTNPTHRRLDAFFHLCLPAVRSSVSPLDVCMEPCVDILSAALLRQFEYTHSIVLDLLRHTQQLDRKTGSATALVVGSSSSSTSSSSATAAAAAAANNFFQPDVLQPTRMCMAIRAIALSLHVYVSGEASALPGGERPSIEDMASEPLKTIPYPSADVERAYTQFFSVSTQIALHCDYLVKDLTVLDDQVPLARGTNVPILHGERALQDAENYEVRAHANGAFTVAYAREHQPHLELLRTCIETWPRCMSSTASKSTCQALLFRGLFSVEPSVQRASAAALMRFARGQDGAQVILRAFLQWFFRKDGVVWELQSHADVLVSQFAHVTDLVADLLALFLSQSEDALSHDTFREFTAGALLFLCLPSAALRRHVIELLLQASLSSVSTATPAAESRATAKFPDTAPPPDAAAVLTCGELFARPCTCFLHEDHPELSASQRARIAKWRSTGDAYPLSRLASSGEHCSLWRMALPNVLREIVSTAPRLAMQLYHLLLGAVQCLEPSIATIAHLRKSAARVPPTLTFVRSTWRMYILTLCTVGIQSTKHVALLVPYLGCEDVDLQDAAADALSHVHEHAYSSLVTALAPLFDNPLWPVRLSIGRILASTASMLPCPSVEPILLSWLHQTLHVLQLDLAPDVHVYQLRRFFCVLLASFYQSLGVESSQHAFPLELRMRLLVVLHDWHSLQDASRLAAQLSAAVERSAAGPKDKVIVSLRHELHLLARHAELAMAALCAGPIDDTPSMHGPTILGWLCDMLAAPSASSRETAQRGLHALLEHNLTHVPLLRALVTQCYRDLAHTQASRTVFLVLVDAWLKLQPLESQTHLAEAQIMCVALCMLAHRDVQIRVGALRILEAYAERQHVSVSFASMAPRVRSSQAASYLEAQRWISYHLSLGHVSSSTSACVLAELTQHMEHIPQAFHQQVLSLLPAWLSAIQFEPESIEHVHLVSLTHMFGVTHPLAVRALWQAVDITPSGARMLLHFLQSRALYYRSVEFIELARMIISSLASSAAQSLQYALYETLSPHAMIPFVPEPATMLPFSLDAWLPPPGTDLMPLPRALTTLLFLSECVSATLLRREHLPVVLHALCMYTDGLPPSLHTSVVRAAEQILCVLATQGLDSAAPPPAYLRAMHAAFSMKRADHVALDDMQVPKKMTALVDALAKLAAPHVPAIRDLWSEVALQWSTNAPNRRMACRSLQIMRALRPTYPALTVPNLVARLADTLALSDAIPYTLEVLNTLEALLATATADVLPPIYWTVVACAGTALEPVFSASLSLLHTWFDQVNMDAETCDALWTSRPSSWDLDAPTLQCMVVRGLRIARTDTTVLHLLVRLAHVPWCELIDSSPEDRVLTLLTAALPWCMQTCDAGKSPAHGAVVTQLADALTLLANDAQRSDIARITTSIARARFRRADDLVRQAATSLALGCTKPRAVHIVSMLILTLYHESVDVCRATLLALVPCLQALHAQGSISTLMPDIPLEPLVRLLRTPLASLALEVLHSPLLVDEAPRSMLQACGWAGPLASLDTKYACTNIRAVSRAWEAPETERGLAFMLDEGDLPETELDALTSQLDDLASFFVQDSTDIPPPDPPSPQSFQVAQILSRSTYSQRDSFSPVPPANLTTPPAAAAWDDASWDMTSRRRSLGSDTSRVFTPSTSATSRVPSPPSTPPIGMGVDSVPDAGEPFFSSTTDTMSSVRMQDHIYEYGHNSEDEQTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT18</accession>
    <name>A8PT18_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732578.1">
        <property type="nucleotide sequence ID" value="XM_001732526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT18"/>
    <dbReference type="FunCoup" id="A8PT18">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT18"/>
    <dbReference type="GeneID" id="5856884"/>
    <dbReference type="KEGG" id="mgl:MGL_0353"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0353"/>
    <dbReference type="InParanoid" id="A8PT18"/>
    <dbReference type="OMA" id="TFPDPNF"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="376" mass="42530" checksum="C083F64437856F10" modified="2008-01-15" version="1">MPTMSAKVDECIALEPQTDATSSLLATQYGSWYPQHKSYTLKSKILNIEAIEPGFLEWLDQDGLVLSDANDVNPEDGDARPQIKRTLPLDSDAEIMSDPSDDEGNDTDDGAYFPALNAEIRRVLLEYDGAVFPKFNWSAPQDAAWIMPGHTLRCQTPNDVYLLLKSSDFAMKDLSQVRELSKACENEARPERPHLQLVLKKWFELPRSHEFRCFVRDGHIVGACQRDMTFYEHLQDAATQERIQSLLFTFYRDHLAHIVPRRIVFDVYLTRHLDTCFLMDLNPWLDRTDTLLWTGDELEHVAPSVGDHGSASGRLVPLRVLASQAEASQALPTYSAHMVPADVVELSHGQNVAEFAQQWTSHVQNAMQPSSEDECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT25</accession>
    <name>A8PT25_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732581.1">
        <property type="nucleotide sequence ID" value="XM_001732529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT25"/>
    <dbReference type="FunCoup" id="A8PT25">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT25"/>
    <dbReference type="GeneID" id="5856887"/>
    <dbReference type="KEGG" id="mgl:MGL_0356"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0356"/>
    <dbReference type="InParanoid" id="A8PT25"/>
    <dbReference type="OMA" id="HYDTVCN"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP45367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="171" mass="18575" checksum="22F7287CF6DED4CA" modified="2008-01-15" version="1">MFTSVKGPAPAPSSFPGAEHLRIGIVHARWNKEVVDELVKGTLESLKKAGADIERVLIQSVPGSWELPVATQHMIKRHRLDAIISIGCVIKGSTMHFEYICDNCLKGLMRVSLDEQVPVILGVLTALNEDQALERAGIGRTKPGHNHGLEWGSAAVEMALMARKDPALSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTA7</accession>
    <name>A8PTA7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732619.1">
        <property type="nucleotide sequence ID" value="XM_001732567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTA7"/>
    <dbReference type="STRING" id="425265.A8PTA7"/>
    <dbReference type="GeneID" id="5856925"/>
    <dbReference type="KEGG" id="mgl:MGL_0394"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0394"/>
    <dbReference type="InParanoid" id="A8PTA7"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="4">
        <location>
            <begin position="61"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="239" mass="25703" checksum="8D0AE2A8547C69ED" modified="2008-01-15" version="1">MYILRVCRGMQNCWRSSRAYEHFCKGAPWTLAEKILYTHLLNPAVDLAGAGADPSKVRGARYLRLGVDRLAMQDASAQMALLQFMTCGMSQSAVPASVHCDHLIQAYEGAQADLQRSLETQHEVFAFLESACRKYGIEFWRPGSGIIHQIVLENYAAPGLLMLGTDSHTPNASGLGCLAIGVGGADAVDALTATPLGVACAESLGRASAWKAVAVVLGQGCDSAPDGRAYRAWRHRLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUG3</accession>
    <name>A8PUG3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732087.1">
        <property type="nucleotide sequence ID" value="XM_001732035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUG3"/>
    <dbReference type="FunCoup" id="A8PUG3">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUG3"/>
    <dbReference type="GeneID" id="5856393"/>
    <dbReference type="KEGG" id="mgl:MGL_0680"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0680"/>
    <dbReference type="InParanoid" id="A8PUG3"/>
    <dbReference type="OMA" id="WVGRHEK"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34361" checksum="98A66C1898E22331" modified="2008-01-15" version="1">MVSSLTDREAEDYLVLILSDSNPPTGGFIASAGLESYYSHGFLTHGQDQLVSSTLSFVEHTLANYATSVLPYMCAAYALADKYVQGDERALDAIGRLDWHHHTLLLNHVSRRASLIQGMALLTLYMRSFAPYPGAKDDEHAQPEPKSHAFRARTLVEQLRLRIRRGGAKLSSGAMSLSATELAGHLAICTGVFSCCVGLSVERMIHVNLFLQARNLMSCSIRLNTLGPYLAHQLLATKLRHVVSRSEALLSRHASEKLVSYAYRDTSQSEDAWLDDELDDTDMDVACTTWPLGDIVQARHDQLHSRLFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUM0</accession>
    <name>A8PUM0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0715</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732122.1">
        <property type="nucleotide sequence ID" value="XM_001732070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUM0"/>
    <dbReference type="FunCoup" id="A8PUM0">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUM0"/>
    <dbReference type="GeneID" id="5856428"/>
    <dbReference type="KEGG" id="mgl:MGL_0715"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0715"/>
    <dbReference type="InParanoid" id="A8PUM0"/>
    <dbReference type="OMA" id="FMCHRSL"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="14">
        <location>
            <begin position="113"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="277"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="715"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="947"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1113" mass="126751" checksum="72EF0889F19FF187" modified="2008-01-15" version="1">MRRRARGVSEDDDDHVARDLELFAKRARIDTPLSSDDESTAVATEMPLLSRVLSDASESEEPSVPPSAIHQQTDSESTLMRGEQSDTQGLAHVAPTPAQAEASAATMGVIERVDMINFMCHRNLSIGLGPRINFIIGHNGSGKSAILTAITIALGGKATTTSRGSSLKDFIREGSSAAEVRVRMRNQGSDAYRPDVYGHAITIERRIHTDGAGTWKIKNADGKIVSTKREELDAICDYANIQVDNPMNILSQDAARQFLGSSQPEDKYSFFLRGTQLTQLAQEYELIQTNVQRMKRAIRMTEDVLPDLEREAREANDKWHQIEQARVEQEKLDALKEELVWSQVIAKEKERAALESKLDHAHRKHAALEKRREDDSLRAKELNDVVAELETRSRESQEKEVQLKEQRAQVLQVVKEHRASLARLKEQERELSHQADRVEQTIRQMQAQIDAEARRQAQDRRAIREAQEAERDELVRERLNVERRQVSLGQAGDEVNVRRSECRAERARLTSDTHVLEEKISHLQSFLERCTEAASNRITAFGGHDMPRIMAAIRRETRWHERPIGPLGMHIRLRERRWAPVIESVLSDPLNAFVVTNHDDRVRLARILKEFRASNQIITAARDLYDYSAGEPDASVVTMLRVLDTDEYIVRVLIDGHRIEKSALVSERVQGDELMRRHLPNVLQCYSADLFKITGGAKSSVTQTITRYTGVPRFAADHAVEMDDARRSIASYEEKLGHVKTALEAVAAREAAYDQEQQRNQQAVEAARHEMRALRQRIAHVEELMREEEPANVAALEEARVEADEEMARIVDRFKQTESEKEEAEESLAPHLAKCEQLLDQIELVEAHRRDAELQLQQSYTERVRLQKTQEHWSRQMDAQNTLVQETSREHASLCELIASWTQMATDYCARVETQRTPASLEEQINAIEAHLQQDEARTGLSVDAVVRELRAKNKAYQEAKLQLEQTHATIQLLEESVQLRLEKWHYFRRFVAIRARANFSLHLQNRGFSGSLHFDHNAQTLRLRVQTGDGTHAHDKDPKALSGGEKSFATICLLLSLWEAIGCPIRCLDEFDVFMDAVNRQVSMRMMIDAARASLGVHDVQIHRMQDPERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUN1</accession>
    <name>A8PUN1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732131.1">
        <property type="nucleotide sequence ID" value="XM_001732079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUN1"/>
    <dbReference type="FunCoup" id="A8PUN1">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUN1"/>
    <dbReference type="GeneID" id="5856437"/>
    <dbReference type="KEGG" id="mgl:MGL_0724"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0724"/>
    <dbReference type="InParanoid" id="A8PUN1"/>
    <dbReference type="OMA" id="SMVRTHH"/>
    <dbReference type="OrthoDB" id="1290869at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="278"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="693" mass="77665" checksum="A023EAEEC8E8263B" modified="2008-01-15" version="1">MIRGSSARALRIGALGLAGGVGILAYSMLQWRFLHSSKDAADTGESKGHDVGPTASISTSASASASDETSSSSSPPPPPKSVVSRVWGAISLYVVEPVLVLKRFLVLAITFAPVVLATPLLVIGHRITYRDEDGHMVEGERWGTVLWYKLLVMQMERAGPTFVKLGQWAGSRRDLFPDELCNRLSKLHSNNKPHSMTYTREVLERVFKRSFDEIFASFDEQPVGIGAVGQVYKAVLHQDLLPSDYLNDRREQDRLQEAAENIGRELALTYEHDESSDHHGAAVAIKVLHPKVHRIIGHDIQIMQFFAGLLNLIPGMRWVSLPEEVDRFAALMLSQLDLREEASHLSRFERNFGGRGGTVIFPRPLRAFCARDVLVEELVEAVPLKHFMRMGGGAYDSRIAEMGLDAFLSMLLIDNFAHADLHPGNIMVKFYRPSMRSMLQNAFSRVFYRFDPDYVLGHRGRTGIIPDDQVSQELVARSNDSDSWHSAIRSIQEDGFLPELVILDAGLVSELSPKNLRNFLDLFAAIAMFDGRQAGSLMVDRCRTPELVTDREQFIRVIEGVMDSVKSETFSLASLNIGDVLNKVLKAVRTYHVKMEPDFVDTVLSILILEGIGRKLDPNIDLFRSAIPILRSLGHKMSSDETQLASLREQVSLKTLLPMLKLWFFMEFRSLFMAPQNSPQIVDAFVRYGWLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUN9</accession>
    <name>A8PUN9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="13">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0732</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="13"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732139.1">
        <property type="nucleotide sequence ID" value="XM_001732087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUN9"/>
    <dbReference type="FunCoup" id="A8PUN9">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUN9"/>
    <dbReference type="GeneID" id="5856445"/>
    <dbReference type="KEGG" id="mgl:MGL_0732"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0732"/>
    <dbReference type="InParanoid" id="A8PUN9"/>
    <dbReference type="OMA" id="QGDGKPH"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 13" id="KW-0288">FMN</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="14">
        <location>
            <begin position="375"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="509" mass="56240" checksum="2723E4918D9B506A" modified="2008-01-15" version="1">MQGIVASRVVGLASKPRLASASRTTLRGLATVSDAPKRTHGGLRDQDRIFQNLYGQHDFRLKGALARGDWHRTRDIIERGHEFIINQMKASGIRGRGGAGFPSGMKWSFMLKPGWEKDPRPRYLVINADEGEPGTCKDREIMRHDPHKLIEGCLVAGRAMGANAAYIYIRGEFFLEAYNLQVAINEAYKAGLIGKNACGSGYDFDVYVHRGAGAYICGEETALIESLEGKQGKPRMKPPFPADTGVFGCPTTVANVETVSVAPTIIRRGPEWFASFGRERNHGTKLYAISGHVNRPCVVEEEMSIPLKELIERHCGGVRGGWDNLLAVIPGGSSTPMIPKEVCERTLMDFDSLRDNQSALGTGAVIVMDKSTDLVKAIARLTKFYHHESCGQCTPCREGTAWLDSMMTRFENGRASLREIDMIWEITRQMEGHTICGLADASAWPIQGLLRHFRPVVEERIKEYVAKHGTVLYGGRLASERRPDLAIPANVSFPDQASKDNFQPGVKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUQ8</accession>
    <name>A8PUQ8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732155.1">
        <property type="nucleotide sequence ID" value="XM_001732103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUQ8"/>
    <dbReference type="FunCoup" id="A8PUQ8">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUQ8"/>
    <dbReference type="GeneID" id="5856461"/>
    <dbReference type="KEGG" id="mgl:MGL_0748"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0748"/>
    <dbReference type="InParanoid" id="A8PUQ8"/>
    <dbReference type="OMA" id="WMASHGI"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000100">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF43">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="104"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="515" mass="57843" checksum="31E649F4B50E4C1D" modified="2008-01-15" version="1">MTNAKFLDKLHDVFHKTETHAPKDVTPWNEPISKRSKYAIRKQRGVNLGSWFALESWLTGSLFQSLNESGSCDMDIVKGMNLEEAKQLLERHWDSFIDDGDWKWMKAHGINSVRIPILYAHFLAGNKEHTKLLKGTDYASFATVYEGAWQRIVASIEKAASLDIGVLIDLHGVPGGQNGDSHCGKSDGNVSFWNGLHASSNRKLTIQILTALAEAVSQYDNVIGLELMNEPQNHSCLEGFYVDAIKAIRASSSPAVAQLPLYIGDGWDTNHYAKYVGKHSDIGNPLVLDHHMYRCFTSHDHRTSAEQHACDLDIGKQGKTAWWLKGISEHAQGAIIIGEWSGALNPGSLRGCANHLDALKSWSHAQWHAFESYTAGYYYWTLKKEGGPDPGWCFYTAVEKGTMPPSLNPLDGGHVDFNALHQQGVELAQRCLQEHTKYWDSKGGNYDHEQYKHGFEMGWKDALEFLQEGAEVGLPNQLAKLRLASYEQDHDSKNAWEFEHGFRQALEAFRRTLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUR3</accession>
    <name>A8PUR3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732159.1">
        <property type="nucleotide sequence ID" value="XM_001732107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUR3"/>
    <dbReference type="FunCoup" id="A8PUR3">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUR3"/>
    <dbReference type="GeneID" id="5856465"/>
    <dbReference type="KEGG" id="mgl:MGL_0752"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0752"/>
    <dbReference type="InParanoid" id="A8PUR3"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF24">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="210" mass="23659" checksum="0DEC0D7C99367BBB" modified="2008-01-15" version="1">MNALIEALQDTQRFPSEKQANNADELAHELIALQSIYGMEEVELKSGANVDEPTLFVVRLPWQKSGDIHVKLQVRLPKGYPNCDEAPTLELVNRTLGSFQIDDAIRDKLSHTFSPEGSAPWVKGEPVLFQGIDSASESLQDWWDERSKSVSYEDDEAPRDTHQKPQTASSRQADLRSLVHSDTILERKSEFLGHAARISHPDEVSERRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVG1</accession>
    <name>A8PVG1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase D</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rotamase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731586.1">
        <property type="nucleotide sequence ID" value="XM_001731534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVG1"/>
    <dbReference type="FunCoup" id="A8PVG1">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVG1"/>
    <dbReference type="GeneID" id="5855892"/>
    <dbReference type="KEGG" id="mgl:MGL_0854"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0854"/>
    <dbReference type="InParanoid" id="A8PVG1"/>
    <dbReference type="OMA" id="EMEQNCN"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000022">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="384" mass="42320" checksum="A802ED8BD012D70E" modified="2008-01-15" version="1">MTNPIVYLDVEFVGGPPPSRQGGHRIVLELFRDKVPKTAENFRALCTGEKGTGTSGVPLSFRGSIFHRVIRRFMIQGGDFTNFNGTGGESIYGEKFEDENLEGKHDEPFLLSMANAGPNTNGSQFFITTVPTPHLDGKHVVFGRVLRGKDVVRHIEQSRTGPNDRPEEDIKIADCGEFSAEQLQDSSFNYGILPDESGDTYEPYPEDSDLPLEEKPDTALHAAQELKNFGAKLVSEGKWALAREKYEKALRYLFVNPHLPDQNEAFVAEYFALRTPLQLNAALCALKTVPPIPDQAEALTTQVIERGARGGLGAPKEADLAKAHFRRALALSAMKRDDEAKADLSQALTYAPNDAGIAKEAAALEKRRQARLAKQRAAYSKMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVH9</accession>
    <name>A8PVH9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731604.1">
        <property type="nucleotide sequence ID" value="XM_001731552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVH9"/>
    <dbReference type="STRING" id="425265.A8PVH9"/>
    <dbReference type="GeneID" id="5855910"/>
    <dbReference type="KEGG" id="mgl:MGL_0872"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0872"/>
    <dbReference type="InParanoid" id="A8PVH9"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="1">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="136" mass="15398" checksum="13343699433099A6" modified="2008-01-15" version="1">MSEQFVAALKNRVADNQYISHIKVREYADNASGAPAQKSAYKTRYIILGQSPSQQRAYVYKARRNANGTLSLGKEWDATQVRSMCRERSMLLVTFSITHRWEVDTSQDPVPFLNHLASIVIRAQGTLPKMSGWSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVK6</accession>
    <name>A8PVK6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein LTV1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731627.1">
        <property type="nucleotide sequence ID" value="XM_001731575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVK6"/>
    <dbReference type="FunCoup" id="A8PVK6">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVK6"/>
    <dbReference type="GeneID" id="5855933"/>
    <dbReference type="KEGG" id="mgl:MGL_0895"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0895"/>
    <dbReference type="InParanoid" id="A8PVK6"/>
    <dbReference type="OMA" id="PRSHMRE"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="68833" checksum="316C8A130BAFEED5" modified="2008-01-15" version="1">MQHLRAIHDTENSKRGGVDEEDDTEAVWIPSAVQPKDRAPGFSLKEDDAGKTSASSSKPTIANQHNLLLPSSVFAADEISLAQAYEEPAPQGLQPDMDPHLRQTLEALDDDAFVDDKLEDDFFTDLVQDGVWSGERTAGDEWRDQAPEGDDIWLDPLERAKKERDAVGGDESALSLEARVALFKEQQKKLAASQGDSDDAHEDEDAAADEEDRDTLGELGPSAAARRSGRRTGSVSSTGSALGKKGKPGVLARRAASMREGSVGGASTAWTMTSSSMFRNEGLTDLDSQFDQVIRSYGGRATGDPALDALTGAFTDVHDGEADMDDPEADELDHETAEKLTRQDLDHILDDFLDHQEVIGGKLRPTLGDRTTTADEKLELVRKALGHAHIREGVDDENEDEEDSHAAQSAQENPFLNPDIIGRDREQWDVETIQTTKTNLENHPRTIRASDSVRGSVTDRSAAPRTVSMSSAIGGHDDRRIPKIRLHPRTGMPQVVGYTSARKPPKCERNEALGSARASSPDSDSNGDGDGDGDDDDDDDDDDESESADNDVGTKPLHAGASQPRGQIHRRDRNESAEERRQRKKAVKQEKQQRKQAKSAAKKAFAAERKRQTHATNRQAESRGGVAGMHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVL2</accession>
    <name>A8PVL2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0899</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731631.1">
        <property type="nucleotide sequence ID" value="XM_001731579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVL2"/>
    <dbReference type="FunCoup" id="A8PVL2">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVL2"/>
    <dbReference type="GeneID" id="5855937"/>
    <dbReference type="KEGG" id="mgl:MGL_0899"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0899"/>
    <dbReference type="InParanoid" id="A8PVL2"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="404" mass="44874" checksum="A7B43EFFC6A801F9" modified="2008-01-15" version="1">MLENAGFRKLHEHQTWNEKLYVGGRYYVQRNQSSLLAFVIGKKYEAGQGVHIVGAHTDSPNLRIRPVSRRTKEGYLQCSVETYGGGIWHTWFDRDLSLAGRVIVTSDKEQSRFVSRLVHIRRPLLRVPTLAIHLNRSANEAFKFNQEDQLQPIMGLADMLNQPRSTPDADAVGKPTMASKHHPVLLELLAQELEVPVEFIQDFELSLFDTNAPTAGGVSNEFLFTPRVDNQMSCFCATEALIASVLDLDALDRATSIRAIALFDNEEVGSVSYQGAESNLLWSMLHRLAGLRVIGAPESTASAQDLTEQSLSRSFLISSDTAHAVHPNYASVHEEHLRPKLNGGPVIKTNAKQRYASTAVTTFLLRRIAKKAGVPLQEFEVRNDCPCGSTIGPMLSKVRVSEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVS4</accession>
    <name>A8PVS4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731675.1">
        <property type="nucleotide sequence ID" value="XM_001731623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVS4"/>
    <dbReference type="FunCoup" id="A8PVS4">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVS4"/>
    <dbReference type="GeneID" id="5855980"/>
    <dbReference type="KEGG" id="mgl:MGL_0943"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0943"/>
    <dbReference type="InParanoid" id="A8PVS4"/>
    <dbReference type="OMA" id="QAMAKMY"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="367" mass="38672" checksum="CCDCFA4F897F5365" modified="2008-01-15" version="1">MFVGGLNWDTDEESLRRYFGQFGPVTSCTVMRDGASGRSRGFAFVTFSDPKSVNAVMVREHFLDGKIIDPKRAIPRPEQSKTQKCFVGGLPQTVTQDSFKQLFQQFGHVLDSTVMMDKDTGRPRGFGFVTFENDDGVENTLAHQPLLLDGKQIEVKRAQSRGQPQPNAAPNRFSSDPARGSNAQAPLRMWGSSPAAASMPGMAGMAAMPSMAGMASGAMAPATDGARSPATGAMGAGGFDPQAMAKMYQQMGWGSSAWNPQLMWQQMMAAYMGTAAAASGAKGGASPGWGAGAQQGNANAAYMRSAYGANGAGQQGSSDAGWGGRGHSGAPSDDTRGRGGGHAPSAYHRERSPSRGSRNYDDRGSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW09</accession>
    <name>A8PW09_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP-binding protein ypt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731733.1">
        <property type="nucleotide sequence ID" value="XM_001731681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW09"/>
    <dbReference type="FunCoup" id="A8PW09">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW09"/>
    <dbReference type="GeneID" id="5856038"/>
    <dbReference type="KEGG" id="mgl:MGL_1001"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1001"/>
    <dbReference type="InParanoid" id="A8PW09"/>
    <dbReference type="OMA" id="DEEGLMW"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000851">
        <property type="entry name" value="Ras-related small GTP-binding family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23585" checksum="ECAF68A86738DEBD" modified="2008-01-15" version="1">MSSVASFKLVLLGESSVGKSSVALRFVKDQFEDYRESTIGAAFLTQTVRRQDGATIKLEIWDTAGQERYKSLAPMYYRNAHCALVVYDITEQESFENAKSWIRELQRHADANITIALVGNKLDLAETSRTVSAEDGQKYADSEGLMFMETSAKTPTNVTELFTLVANKLPLDRGMGVKRGESAAGGGSGGAAGASARPANGPVKLGTSSQPSTNQDACSC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWG8</accession>
    <name>CLP1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA cleavage and polyadenylation factor CLP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CLP1</name>
        <name type="ORF">MGL_1095</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">May lack the polyribonucleotide 5'-hydroxyl-kinase and polynucleotide 5'-hydroxyl-kinase activities that are characteristic of the human ortholog.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731827.1">
        <property type="nucleotide sequence ID" value="XM_001731775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWG8"/>
    <dbReference type="SMR" id="A8PWG8"/>
    <dbReference type="FunCoup" id="A8PWG8">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWG8"/>
    <dbReference type="GeneID" id="5856132"/>
    <dbReference type="KEGG" id="mgl:MGL_1095"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1095"/>
    <dbReference type="InParanoid" id="A8PWG8"/>
    <dbReference type="OMA" id="DITGWWP"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000375210" description="mRNA cleavage and polyadenylation factor CLP1">
        <location>
            <begin position="1"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="195"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="665" mass="73010" checksum="F87B068A9EAE91B6" modified="2008-01-15" version="1">MEDIVDDVRSSTYQVVENDACGTGKANLLSLSLLYLRSTLKWMIELDAGEAVAIRFVPDPISGHYGDAEVFGAPLVAGSQERWYTFGNEAKFAISSWGGAEVEILGAASTEYMADEPSPTYTYCTNLHLNLERARIRAREQLRTDPSLQKILEDMDVSERTIPASYEQHGAGASGSDLYRAAGQGPRVMIVGPESAGKTSLIKFLANYALRSPALANVKEGDDASRRAKHRSEPEIHPGPDVAHDDDDDDDVENRKDDEESGINDMKHPKNRKKHSSADSQAKKTLSDITGWWPMIVALDPSEGAVPVPGCVSAIPLTPMPTNWLPSPSPALPYGITTQTTGTLPPSVSTVQSVMPISLWMGKENVRENERHSRRVIDWLAYYIEKRLVKDWRARMSGLLLDMPGVITADARTRYGFIQYCVRAFKIDTIVVLGHEKLNLELTRIYANDTSGHAPRIVKVPRSGGAVEVDEVYKQKLHDLQIRSYFYGMPPALTKEAAVTSMSMNDENTPASIPAGLDEHLGAVPTLSPYSTTIPLDLLSIYRVGQDRVAPSSALPIGAERVLSEMQVVKLDPVNSSNDMSMLLHSVLALVEPPPRNQSKDETSSPDDPGHHDYEDDELLGAAILGFVHVSDMDLHRKKLTVLSPKPGKLPSTTALIGNLQWQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWJ5</accession>
    <name>A8PWJ5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1122</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731854.1">
        <property type="nucleotide sequence ID" value="XM_001731802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWJ5"/>
    <dbReference type="FunCoup" id="A8PWJ5">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWJ5"/>
    <dbReference type="GeneID" id="5856159"/>
    <dbReference type="KEGG" id="mgl:MGL_1122"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1122"/>
    <dbReference type="InParanoid" id="A8PWJ5"/>
    <dbReference type="OMA" id="NGPYTAL"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="11">
        <location>
            <begin position="91"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="12">
        <location>
            <begin position="361"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="530" mass="58504" checksum="7816A531FA5CD235" modified="2008-01-15" version="1">MLEVGEGGMQQQADEHADRRCPVPHAKNTPLPPGHPEVPNAIPSKLKPPSGEHCIFLRQSDDTQAPEADPSRPVVLPPNMTNVQDSYYTLVLSSRKSELAVRQATQVQMLLDTRYGRASPVFAPGADQWPSTEVANIRAFLRTFSPDQKDVRPVDFPVRTMATLGDQNLKSPLYVIGGEGRAIWTKELEVALMAGGVDAIVHSLKDVPTTMPDGVELAAILEREDPRDALVVKENLPYKSLQEMPQGSVIGTSSVRRVSLLRRAYPHLMFSDVRGNINTRLAKLDAADGPYTALVLAAAGLKRMDLEHRITAYVSEPVMLHAVGQGSLAIEVRTPRGESAERDERIRRMIRSISNWRATWRCVAERALMHRMEGGCSIPLGVSTRFEDHADIEGLLNERNETPSEMASAGISRPDIRIAHEPPPQGSFLTMAAVIVSLDGTRMCKHSHTQLCRSEKDAEQLGILVAEELEHHQNARAILAEVEHHRHLAEVADEKRRAAQKAGEAVDSQVKEVDRRGLPRDDGVAKAWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWP8</accession>
    <name>A8PWP8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731907.1">
        <property type="nucleotide sequence ID" value="XM_001731855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWP8"/>
    <dbReference type="STRING" id="425265.A8PWP8"/>
    <dbReference type="GeneID" id="5856212"/>
    <dbReference type="KEGG" id="mgl:MGL_1175"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1175"/>
    <dbReference type="InParanoid" id="A8PWP8"/>
    <dbReference type="OMA" id="WAGIGGI"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="64" mass="7425" checksum="F6870441935AC411" modified="2008-01-15" version="1">MDPIVYKNNNILQRQRIYQSDLRPVYQRLPRSGLYMGIFQIFFWAGIGGITVGAFNMITLDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWU5</accession>
    <name>A8PWU5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1221</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TFS-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731953.1">
        <property type="nucleotide sequence ID" value="XM_001731901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWU5"/>
    <dbReference type="FunCoup" id="A8PWU5">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWU5"/>
    <dbReference type="GeneID" id="5856258"/>
    <dbReference type="KEGG" id="mgl:MGL_1221"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1221"/>
    <dbReference type="InParanoid" id="A8PWU5"/>
    <dbReference type="OMA" id="RFVVMTH"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="143"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="304" mass="33790" checksum="89841B1D9A83E4ED" modified="2008-01-15" version="1">MSSSSLERTRELSKQLSKSTADSNVEDILSLLRQLKEVVVPSEELIRATKIGVAVGKLRTHSHARISELAKELVKSWKSQIEKQRRESPASEKSKKDAASSADTKSSSSSSSSLSSSAAPASNSSSTNSKNVDINFEVLNDRVRNACLKLLYNSLEVQDHAEPQTVFASAMKIEEAAYTKIGASTTNNDYRGKVRSLSLNLKDKNNPELRQKVLEGHIDPGMLVVMRSEELASKSLKEQQESIRQQNLHNAKGAEAQEAETDAFQCGKCKQRKTRYYQMQTRSADEPMTTFVTCVNCNHKWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWW2</accession>
    <name>A8PWW2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731970.1">
        <property type="nucleotide sequence ID" value="XM_001731918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWW2"/>
    <dbReference type="FunCoup" id="A8PWW2">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWW2"/>
    <dbReference type="GeneID" id="5856275"/>
    <dbReference type="KEGG" id="mgl:MGL_1238"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1238"/>
    <dbReference type="InParanoid" id="A8PWW2"/>
    <dbReference type="OMA" id="NNDYQCE"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="283" mass="32683" checksum="AD6CFFE9F730EEE7" modified="2008-01-15" version="1">MSERKVLQKYYPPDFDPSIVKRRKTGGGRQKTVRLMAPFSMRCNTCGEYIYRGKKFNARKETVNDDDYYGITIYRFYIKCSQCSSEITFKTDPKNSDYAAEHGASRNFEPWREHDKEKEPESGSEHEQDGDEPDVDPMKALEQRMAESQREMEVMDALQDIRTRNARFERMDTSTVLGAIDENKRKVASTAERSTNSRREADEQEEEEKEEEALVRKYFRHEQPNDVSSITATAASDTNIPNTSHLLSERTREQLRSLAVPTQNKPAPKRKRGPNALGIVRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWX5</accession>
    <name>A8PWX5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731983.1">
        <property type="nucleotide sequence ID" value="XM_001731931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWX5"/>
    <dbReference type="FunCoup" id="A8PWX5">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWX5"/>
    <dbReference type="GeneID" id="5856288"/>
    <dbReference type="KEGG" id="mgl:MGL_1251"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1251"/>
    <dbReference type="InParanoid" id="A8PWX5"/>
    <dbReference type="OMA" id="AMAFIPD"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="68"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="575" mass="63018" checksum="B4096081A39D4566" modified="2008-01-15" version="1">MTLLQNWVDGFKPAITEEDYELQSENEKRHESTLSYEGENSDSVNSKDMKNIPATKRPILKKSLKSRHLAFIALGGGIGTGLFVGSGSTLAHGGPGSIIIDYTLMGFMILTVLFALGELASLYPLPGAFSAYSRRFVDPALGFAIGYNYLMQWLATFPLEFTAATIVISYWNKDESMPNGAIVAIFWVFIIILNLFGARGYAEFEFCATSLKMLTLIGFIICAAVIDCGGAPNGGYRGAGTWYNPGAFNNNFKGFCSVLTTAAFAFTGTEVLGLAAAESSNPRKFMPRACKLVMYRVIVFYALSLFMVTLLVPYDHPMLTVGKSGNNPNSSPFVLAIKSGGIRVLPDIVNAVIMLSAISVSNSAVFAASRTLHALAGQGMAPQIFTYVDRAGRPLVAAILSLLFGALAFMVYVGDDHGAEVFNWLLAISGLSILFTWASICLSHIRFRAAWVRQGRPLAGIPWQSPLGVYGSYIGLIFNVLVVIAQFYNSAFPIDEGDLTSDRRAYEFFLGMISLVVFLVFFFAYKIVKRTRIVPLEEIDLDSGLREVEPMEVLEQERAQIRSLPLGKRLLHIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX62</accession>
    <name>A8PX62_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxamine kinase/Phosphomethylpyrimidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731155.1">
        <property type="nucleotide sequence ID" value="XM_001731103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX62"/>
    <dbReference type="FunCoup" id="A8PX62">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX62"/>
    <dbReference type="GeneID" id="5855462"/>
    <dbReference type="KEGG" id="mgl:MGL_1338"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1338"/>
    <dbReference type="InParanoid" id="A8PX62"/>
    <dbReference type="OMA" id="YERESNA"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="176"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="286"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="55720" checksum="2E8E17D51B4F3F25" modified="2008-01-15" version="1">MVATSGSLLLEDDAISTMRDQLFPLATLVTPNISEAICLLEDTSHEVPDSNCPSILSLQKMAKCLSKLGATNVLVKGGHASMSYDSLIDQLYRLGVKLLSINDLDQVSKAYERESNASLLLQYERSLKGRGGNSHDSELTTAAHVLGASLYRTYNGVDICYVRGPDDLLFLQRPSSAYTTDVLYESQSERMTLFIKPTINTDATHGTGCTLSSAIAAFSAHGHPLRVAVAHALQYMQEVLASGLNQVGYGAGPLDHGSPIMTRGIPLRALSNPAPLTTMLVSQSWSLWKSYTRHPFVQNLGDGTLLMSSMRWFMQQDYKYLTQYARALSKAVAHPSATWSEMKELSAMSKSVIDEMQLHIRVCERMGISLDVLEQTMESRATVAYTRFVLDTAEEGLLPLLVSLGSCAVGYAEVGLWLSQKCASGTFPGELYNEWVKEYSGPAYQRAVHGFVNLMEEYAQRAMISVSQMSRLQTIWDAVTRFEIGMWDEALSVGYHAVPDEFHSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX69</accession>
    <name>A8PX69_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731162.1">
        <property type="nucleotide sequence ID" value="XM_001731110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX69"/>
    <dbReference type="STRING" id="425265.A8PX69"/>
    <dbReference type="GeneID" id="5855469"/>
    <dbReference type="KEGG" id="mgl:MGL_1345"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1345"/>
    <dbReference type="InParanoid" id="A8PX69"/>
    <dbReference type="OMA" id="FYLFHNY"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="113"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="448" mass="51802" checksum="69242A077C0C76E2" modified="2008-01-15" version="1">MVSDSVEKPTSETRPRYAPRKAKSYDTDKLHQYVVPDLSMQDLLSAIPTQCFRRSTLHSSMYVMIDFAQAAVLFYAASWIDPLTQDMHWSFLSMSEESTRSALRFILWGLYSFCQGLVFTGIWVLAHECGHQAFSPSKFINNTVGWFLHSALLVPYHSWRISHARHHAATGHMTRDEVFVPSTREERGLLPLRPVDDDSPVVTDKTTWSEWLAELLEDAPLFNLLELIIQQLFGWQLYLLFNVSGQKHYPRYTNHFMPNSVIFDKRHRNQIIMSNVGILLTLTVLWTWARHASNGWFDVMRYYGIPYVWTNHWLVMITYLQHTDVKLPHYHASMWTFPRGALCTIDREWLGFVGPWFFHGIAETHVLHHVSSRIPHYNAWEATEALKSRIGPHYMKSTENVFVSLWKTIRSCRYVENEPVTFYRNADGVPGSVAVLSAGTDSGVALSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXG1</accession>
    <name>A8PXG1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731254.1">
        <property type="nucleotide sequence ID" value="XM_001731202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXG1"/>
    <dbReference type="FunCoup" id="A8PXG1">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXG1"/>
    <dbReference type="GeneID" id="5855561"/>
    <dbReference type="KEGG" id="mgl:MGL_1437"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1437"/>
    <dbReference type="InParanoid" id="A8PXG1"/>
    <dbReference type="OMA" id="ADKYQCD"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="126"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="463"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="574" mass="63031" checksum="08F6556DE2DA962E" modified="2008-01-15" version="1">MAQTVPGTRLGKVHKPGARAQHVLEDAIKPGAHLRSLLDEPVRFVGSSRDELKASLSLDAARASNMEIVNEPVDAQPSRSSKRTNDNADASASTAGTSLRTVSAPTQPLYTPRIIPRFPRAHMRAAGLHNRGNTCYMNSVMQSLLHTPPLATALLTQSAPTLLGRYGVPRTQKQAVKAANSFNALTEMKDFFAHAYSGASAVSPTAFVSNLRKFARPLRPGRQEDAHEYLRLLLEALQQACTCFAGKDIKPNDPILSTTLIQRIFGGRLRSRVTCYSCRHNSDTYDPMLDLSLDVRKGIHTVKQALDAFTAAEALADKYQCDHCQRRVEATKRFSIDQAPMVLTVHLKRFGIFGNKINKPISYSDRLHLGRYMSERDKGLGADVEDEPDLGTLGAAQQYRLFAIVHHYGSGPNVGHYVASVRSADGQWLRMDDSFVSKLPQCPLDDPSAYLLFYLREPITMEESSKPTTMTSPKKRKAASIKRDDDGHDHGPGVSADIVMGEPVSRAEYARLRESLDAGTEDGVDNDGSTESPSRDSGGIDSGSDDDVVGAQPVMSKKEIRRRKRRKASSAHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXI2</accession>
    <name>A8PXI2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731270.1">
        <property type="nucleotide sequence ID" value="XM_001731218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXI2"/>
    <dbReference type="STRING" id="425265.A8PXI2"/>
    <dbReference type="GeneID" id="5855577"/>
    <dbReference type="KEGG" id="mgl:MGL_1453"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1453"/>
    <dbReference type="InParanoid" id="A8PXI2"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="87"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="230" mass="24783" checksum="666055DED6582178" modified="2008-01-15" version="1">MASTDNGVLSSAPTAGMPSSQGEDVGVSDVTSLKGTETATAPNMVPGFGIGSATSESPDASKSNPDTSGRSWPPSLPPLPPHLMGADLPIANISRIMKRALPDNGKIAKNAKECMQECVSELISFVTSEASDRCGSEKRKTINGDDILYSLRVLGFDNYEQVLKVYLSRYRQAQEENPRQRRRRAMKRRSSPASLHESLVGEGEFPAPHDEDAQEDDDEDAVSEDAGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXN3</accession>
    <name>A8PXN3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MRG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731304.1">
        <property type="nucleotide sequence ID" value="XM_001731252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXN3"/>
    <dbReference type="FunCoup" id="A8PXN3">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXN3"/>
    <dbReference type="GeneID" id="5855611"/>
    <dbReference type="KEGG" id="mgl:MGL_1487"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1487"/>
    <dbReference type="InParanoid" id="A8PXN3"/>
    <dbReference type="OMA" id="GLQTYFD"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MRG" evidence="7">
        <location>
            <begin position="80"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="329" mass="35801" checksum="533DD890496B66E6" modified="2008-01-15" version="1">MENVARQKALVDAQKAEAAAAAAVAAAHAAEQTNARSKREESRKAAAATATSASGSATGSSTNSSGATSGATSGSGRGSKRSRDASDADEHERRPEIHLTIPESLKAQLVDDWENVTRKEQLVPLPRKPNVKSVLREYADHYQKTHAQHTRTLTVLNEVLAGLKLYFDKSLAHNLLYRFEREQYVQMRKQHGPKMGDGDVQTDIAAVKPTTRRGRASSSFSTATPSTPSTAASATHSEQATESRANDSSPSLGSHSELEASEIYGAEHLLRLFVNLPCIVAHTTMDAESVAILREHLNEFLAFLAKEQKRFFVHDYEDPSPAYHRLNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXQ1</accession>
    <name>A8PXQ1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731316.1">
        <property type="nucleotide sequence ID" value="XM_001731264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXQ1"/>
    <dbReference type="STRING" id="425265.A8PXQ1"/>
    <dbReference type="GeneID" id="5855623"/>
    <dbReference type="KEGG" id="mgl:MGL_1499"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1499"/>
    <dbReference type="InParanoid" id="A8PXQ1"/>
    <dbReference type="OMA" id="FEIFARW"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="471" mass="53846" checksum="EABF75D9CCFA0DF1" modified="2008-01-15" version="1">MNASMLDFPPPYAIVAQESNPQTSSRPSSVTHSSPEATMQSLETDATSVSSLDLIPSDDDEQTLSDFVHIKRFRSTPQLSSSTTSSAMPIDHRTLHRRRHGNFSNYQRFFSMVPSLLVNESFSPVTKETTEEVEPLEPLPMAFEVLLHTLRLFAVVPGLIGTVYMLHASYVQARQNRWLRDTYLPLTPSAIEYVACSLWSICTAFHALSLMTMLLRRWLIYYTLVPSLIRLITFQAICWSLVRAVLLLFGPAQPVASWIIVSTFTSFFEIFARWITSNITDVDDTQSTDGLLSDMNETGASDAEGMLHSEQEIMYDSYQPRARHAARSHRYQKYRNQSLRVIRALTGAPTEVTPSDSDSDTFSKPESGFSSSVQEDMNALSPVVDMDHWHRRLIARRNRKRQHRSRHKRSKQKSRMSAFFQNYRAARIHSRRVFHWNVAIWRNVVPIGILGYLTLWVLLAEFTITRFQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY05</accession>
    <name>A8PY05_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731382.1">
        <property type="nucleotide sequence ID" value="XM_001731330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY05"/>
    <dbReference type="STRING" id="425265.A8PY05"/>
    <dbReference type="GeneID" id="5855689"/>
    <dbReference type="KEGG" id="mgl:MGL_1565"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1565"/>
    <dbReference type="InParanoid" id="A8PY05"/>
    <dbReference type="OMA" id="TTCTRNI"/>
    <dbReference type="OrthoDB" id="5588482at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725389" description="DUF7729 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="2">
        <location>
            <begin position="36"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="334" mass="36978" checksum="ECAFA40F8663B91D" modified="2008-01-15" version="1">MWAQWLGLVVGSVPLAVQGLAGSSNMPTIDYIPNDISSNCSTLLTQLDEDNLFQQCTEPLINATNAFAVESTTVNSSDALQSSLRKLCDSGTGCDRSLVRHFLGQFWDQCSDELEKPNDQVLKLYNYLYIFNPFHDAVCSKDHTGQYCLSSIVRTMAQQEDSQLSRMYRRSVPDDIVADVYSDEYWERVLESIPRSRNVSFAKTPSNSSTNTTQLPEVKPQQAFFFLSGSSDKSSLCTECSQNVLAAYIAFELTSPYALGLENSDVLKSQHEIYDHARSLCGTEFLQTVNQKAGVQGFSGPASSATVSSVRRPLDPSWLCALIVLGTTVLWYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYE4</accession>
    <name>A8PYE4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hamartin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731463.1">
        <property type="nucleotide sequence ID" value="XM_001731411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYE4"/>
    <dbReference type="STRING" id="425265.A8PYE4"/>
    <dbReference type="GeneID" id="5855770"/>
    <dbReference type="KEGG" id="mgl:MGL_1646"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1646"/>
    <dbReference type="InParanoid" id="A8PYE4"/>
    <dbReference type="OMA" id="WANITDK"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="844"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="598"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="696"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="879" mass="97320" checksum="86809DF5224FDCB7" modified="2008-01-15" version="1">MPPPSFTSQSAYQINAPRATISLLKEATQQVYALVEKGAIDGAAPAMPAIHALLTELRLHDEGLDVDVSVDAPSRSTACEAVADRFQSDLMELWANITDKSVALHALMLQTLEASALLLGPARLMAYWPDALLWPALALELLSAADAARVNRLCVFVMRSVPMSMYEEVLTNAHASMHAKVSHATPGTKLHAATGAHGNPEAGLDKTSGASVSVSSEKPASLAAIASSSKPILSSASAAFTAATASLSSAASTAATTSTTPTPSTTAPTASVAVSHQAAEAMKFTQLVFDLFADRPAHQGATIAPALHHLDAILSLYSESRPMPFLHHVATTLSPTRVGILNALIRFVQHHSMHIYHITSTHLMDKLFTTLMELDSPACLHLGIKCLVMILPHIPAWLARNGAGGLAHLLRVYAHVIMCLSSASTACSDTSRHVRLLFTMIYGLFPCQFLFFLRSPASCLAQLGDPEAWDDAALTSKVQSHSLALLQCHFVHPSLAMYDASSEQRSRTWQSQDVSDLTARCLRLYAPPPTQHDNEREPPLPITAELPSTPYDVLLVQNELRFELYMKEQLLMHIGHLHRDRITDTASEAEHQHLQHTIRTLRAQLQGINARFDRQRAEMQAANARHMQWERELNAKLNSYRDERRAWTVRVQNLERELEQARRMTKSQADVISSMGARLFTAQSDLAMAAPKLARLQRYDASVHRLEGSLSEWEDKLTILDQQREEMNKLLLRFRGMELAVVNSERSARQHSQLAESLSFENEQLQRDLHALRTKLLQQHERVQALEEQRLRALSTPQVSMDDVRALRSKNEQLELELLDCRAQLELRALEQKQCEPRGLMTPYAHETTLFSPNTLRTPQDASREEDHVPPLSLGPPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYE6</accession>
    <name>A8PYE6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_1647</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731464.1">
        <property type="nucleotide sequence ID" value="XM_001731412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYE6"/>
    <dbReference type="FunCoup" id="A8PYE6">
        <property type="interactions" value="735"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYE6"/>
    <dbReference type="GeneID" id="5855771"/>
    <dbReference type="KEGG" id="mgl:MGL_1647"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1647"/>
    <dbReference type="InParanoid" id="A8PYE6"/>
    <dbReference type="OMA" id="TWCIYPM"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042559">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="15">
        <location>
            <begin position="14"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="14">
        <location>
            <begin position="175"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="270"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="13">
        <location>
            <begin position="583"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="695"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="187"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP44250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="858" mass="96219" checksum="CD70E4DBFA01AEB8" modified="2008-01-15" version="1">MAPKLDTNDPQVARLIELFATISLTGQRAADTIKNPKYARALEHTITALQLDRQGLDAKTGSAVVVAASSGAELPEAKLDYIVQRVLKKDLVSTDQIQTACKYAASVDAIDDATFDSQCGVGVVITPDMCHNVVRNYMQSHHADIAEAAGWPKMSSIMAAVRAEPTLRWANAADIKNAVEQELTAQFGPRSAAAASKKKGGGAASAATKSTNATPSSTSKGERKSKKEETVRPDAMFEEGFLASLHKPGENPQKLPRLRDEHLKATNGSVMTRFPPEPNGYLHIGHSKAIAVNFGFARFHKGLCYLRFDDTNPAAEEEKYFVSILETVRWLGFEPFKVTYSSDYFDRLYELAVDLIRRGLAYVDHSTPEEIREGRGGPDKGERKESRWRHRPIEESLQAFDDMKNGKYKPGEATLRMKQDILGSGNPQMWDLIAYRVLDAPHHRTGSKWCMYPTYDFTHCLVDSFENISHSLCTTEFILSRESYEWLCDALEVYKPRQYEYGRLSMEGTVMSKRKMLKLVNEGFVDGWDDPRMYTLIGLRRRGVPPGAILSFVSQLGVTTNNSTIQINRFDQTVRQYLEMNTPRLMMVIEPLKVVIENLPDDFVLHVTKPLHPKVPDMGQVSAPFTKTVYIDASDFRMQDAPDYFRLAPGKSVGLYQVPHPITCTSVRTNEAGHVVELVCRYEQGPTPVVPKTYIHWVAEHAPSKSPVHVREARLFNSLFTCENPAAHDNFVDFINPRSREILHGAMIEVGFYQVARMSLETAKREAEERVKQAVKQTEEALGKDRAHEARDTNAIQSTESHTYGKECIRFQAMRVGYFAVDSDSSMSLFGDREDESPDDLVLNRIVSLKEDVGKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYH3</accession>
    <name>A8PYH3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">MGL_1662</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731479.1">
        <property type="nucleotide sequence ID" value="XM_001731427.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PYH3">
        <property type="interactions" value="655"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYH3"/>
    <dbReference type="GeneID" id="5855786"/>
    <dbReference type="KEGG" id="mgl:MGL_1662"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1662"/>
    <dbReference type="InParanoid" id="A8PYH3"/>
    <dbReference type="OMA" id="LSANWMW"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000024">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="61"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="212"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="490"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="717"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="916"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EDP44265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1392" mass="151543" checksum="D9584675784B9CDF" modified="2008-01-15" version="1">MNPSKQLLCLTLLGPSTMLEAKRQQLLEQVQNVAPHVRRVDGVFLHMVLVPTQEAYKDLQNASSAKRVRLDDLLRYGDDIAFEDTRGVVQKALEGQSTPGKDVLFVLPRPGNTTPWASKATDISHICEMDDTIERLERGMAFVLDVSEPLNADEFHHAQSHLHDRMTQIVTRDPPVFLANELFGSSEPSPLRVVELLSSASDTNWDAAHDRLAESNTKYALALAPDEINYLVDAFVRGQGDVAPLRRNPTDVELFMFAQINSEHCRHKIFNAAWTIDGKKQPLSLFAMIRNTEEKTPAHTLSAYSDNAAVLEGSEGVRYMPSPDVRVLENNDRVSHLYVGQRESMPILAKVETHNHPTAISPYPGAATGSGGEIRDEGAVGCGSKPKAGLTGFMTSNLLLPGDGRQPWEEDIGYPMHVASAFEIMRDAPIGASAFNNEFGRPAITGFWRTLCERVPTENGFEWRGYHKPIMLAGGVGNVRRSNMLKGKIQPNDVLIVMGGPGYLIGLGGGTSSSLAGGGSERSKLDFVSVSRENPEMQRRCQEVIDACCSSETNPIVSIHDVGAGGLSNALPELVHDAGLGAVCELRNIPLGNSSLSPLAIWCNESQERYVLAVRAHDLARFKAIAERERCPVAAVGHATSEQRFVLTDRLREETCIDLPMSTLFGKPPKMDRSSEHVKRQLRAFDSSLATYLPGLDENARFAAAVDRVLHLPSVGSKSFLITIGDRSITGLVARDQMVGPFQVPVADVAVTRTSHSFDDNAAGEAMASGERTPLSLFSGAAAARMAVGETLTNMAAAYIDDIRKIKLSANWMCSAGFQHDGAVLYDAVQAVGMDFCPRLGVSIPVGKDSMSMGMSWRSDRNENEPEHETRTVTAPVSPIVSGFAPVANVSQTWTPTLRMLDDSCLLLVDLGHGRQRLGGSALAQVFREVGTEAPDVEEPEVLRAFFSAMNIMKQMHAGMPHSAPLVHAYHDRSDGGLLATVLEMSFAGRLGLDMDITGILRDTPMAALFNEELGAVLQVCVKDVSAVTSVLTSMGVPSNIIHTVASVRGDEQINIKCRGETLLSSTRAALQKAWADTSFRMQSLRDNPECAKQELAFIDEPAESASLKYELTFHPAKTLQWSNPASIERPLASQPRVAILREQGVNGHIEMAWAFASAGFSTYDVHMTDLLNGHQSLEPFVGLAACGGFSYGDVLGSGRGWAQSILHSSRVNEEFARFFARKDTFALGICNGCQMLSTLGHAGLIPGAENWPLFGPNESGRFEARLTNVKIQPSTPCIFFRDMDSSIMPVPVAHGEGRAVFRDSSRLADLQQQNGIALQYTDSRYPHNPNGSAANIAGATAADGRVLIMMPHPERAVAKQSLSWAPDHPSNEWMGYSPWFRMFENARAFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYR0</accession>
    <name>A8PYR0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731525.1">
        <property type="nucleotide sequence ID" value="XM_001731473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYR0"/>
    <dbReference type="FunCoup" id="A8PYR0">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PYR0"/>
    <dbReference type="GeneID" id="5855832"/>
    <dbReference type="KEGG" id="mgl:MGL_1708"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1708"/>
    <dbReference type="InParanoid" id="A8PYR0"/>
    <dbReference type="OMA" id="PPDHKVE"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF14">
        <property type="entry name" value="ARF-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="375" mass="40384" checksum="7118F8ED63488872" modified="2008-01-15" version="1">MSMSYASRKPQSRAETEANARTLRSLVKQPENKQCADCKRNDTRWASWNIGCFLCIRCSGIHRSMGTHISRVKSIDLDIWTPEQMHSIQKWGNKRANAYWEARLKEGHAPPDHKVESFIRSKYELRRWAMDGSPPEDPSVLDADKPSVTPMTTANETTSIPATVSGLSTGARAQAELTSATRANMSGAPEIQRSAPTGSLMDLLNDDTSNSTANIGAAPALTPKPAISGSGSASTKNTGRGGGLFDLDWDDTASKDPVPSVSRPTSAPKKNPAKDQILSLFSAPPPSSVKPASLDNPFASMSSGNHRDLTTDMASINLGSSPIQSTNSPIQARAPPTSDIFNTQDIWSSPTHPEQSSASSSKNEDVFANIWGDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYS0</accession>
    <name>A8PYS0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731530.1">
        <property type="nucleotide sequence ID" value="XM_001731478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYS0"/>
    <dbReference type="GeneID" id="5855837"/>
    <dbReference type="KEGG" id="mgl:MGL_1713"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1713"/>
    <dbReference type="InParanoid" id="A8PYS0"/>
    <dbReference type="OrthoDB" id="3365305at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="122" mass="13197" checksum="ACD6AA204EA5575E" modified="2008-01-15" version="1">MGQGPSPNTKNDAQMFDSLTLHQRLGSLLLDLQTGSDQVQSVWEMWHDPDSDCPLALVDKPQTAPPPGSPTVKPADIPNEPNENVIKYSEISSTGDSELNLDALHLGDTTGDLVFKVSNQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ29</accession>
    <name>A8PZ29_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730884.1">
        <property type="nucleotide sequence ID" value="XM_001730832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ29"/>
    <dbReference type="STRING" id="425265.A8PZ29"/>
    <dbReference type="GeneID" id="5855191"/>
    <dbReference type="KEGG" id="mgl:MGL_1883"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1883"/>
    <dbReference type="InParanoid" id="A8PZ29"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="77242" checksum="7627336D1CD03B3D" modified="2008-01-15" version="1">MNAAERMDMLGVQGWMKVEMLCGNPVGAIQLFHAYVAARRRARAQTESMQEPHLLDAGQRREPVRDMIEVLILAYATEQDLHGLVHTMQSFDVGTHTELFFDLAHSQRQFTKLPWLRGNAAFKLPADVCERALDWVSHAELARGLLDGSGGHAGPNRIARLLGSLLARGDVPSAWRLYQTAMRAGVLQPTSPAAWLAQEQLAPQERERRLLPAWTDSAWVVCLSGFLAADRRDLAAQVWEDLAAVQPLVAATGAEWPPVAVWNAVLDGFSRCGDMASVQATWHVLQGHLPVERMPLSHRAKGLRAPPDGPDLVCYTTMMSALFRARQVDMAMTLHNELQAKQARQELRIPIETYNAVLHGLCVSRRTEEAYALLRSMGRNGVPAPTITTINVVLRAQARQKNLPAMAATLRQILPLGLRPDVITFTTVLDTLLRVATQPAAAEQAVDQVMQIMQSMHVQPNSITFTAMIKACLHTKGDLHQPRLPVALQLMHTMCTNVKLAPTPVTMEIMTEGLLQNERFVETMLMEYPLPSTFQRAPVMWPDEQHEMPLHATRLALVLWQLMMDWSMTPTNDTYLLLVRTLLKDGTNHVLFRRGVLIADALLYAQGSLSALVNAPTNLYVILPSTPPASASWSAVLRALIRSRPSDLSRRVLHGVLLHFAQSPHGEQALIGLQAANPAAHLTALVEQARHKLGRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZ66</accession>
    <name>A8PZ66_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730893.1">
        <property type="nucleotide sequence ID" value="XM_001730841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZ66"/>
    <dbReference type="STRING" id="425265.A8PZ66"/>
    <dbReference type="GeneID" id="5855200"/>
    <dbReference type="KEGG" id="mgl:MGL_1892"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1892"/>
    <dbReference type="InParanoid" id="A8PZ66"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="44" mass="5086" checksum="AA87ABFB90C865F1" modified="2008-01-15" version="1">MYFKPDNSVRKWAAPEAEKRLDESGSEWRYKPSPNSGYPDGIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZW1</accession>
    <name>A8PZW1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730956.1">
        <property type="nucleotide sequence ID" value="XM_001730904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZW1"/>
    <dbReference type="STRING" id="425265.A8PZW1"/>
    <dbReference type="GeneID" id="5855263"/>
    <dbReference type="KEGG" id="mgl:MGL_1955"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1955"/>
    <dbReference type="InParanoid" id="A8PZW1"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="171" mass="18683" checksum="AB317CA3253C4BAE" modified="2008-01-15" version="1">MSRSSAPAVLERVSLATPMPRAVAQALQARRIGGEPMCISIPEAVERAVSQMQPMERRVPLWENVILTGPMALTRGLNAELVRALSAYMTTEATEASQVAGEPHPWQPHAVRALRIPDYFANFKERMDLAPYLGATIFAKLVFGDLSGRNYITKKQYNEAGPSVAFALGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0B2</accession>
    <name>A8Q0B2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731008.1">
        <property type="nucleotide sequence ID" value="XM_001730956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0B2"/>
    <dbReference type="STRING" id="425265.A8Q0B2"/>
    <dbReference type="GeneID" id="5855315"/>
    <dbReference type="KEGG" id="mgl:MGL_2007"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2007"/>
    <dbReference type="InParanoid" id="A8Q0B2"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="165" mass="18365" checksum="29FE0A0F2712A54C" modified="2008-01-15" version="1">MSTRPASTNGNESSETAIHVQKISPPPLFAHVCPYIYRSADPSTSSDSFAFLDTLSLKSVVLLSIEYPSKQLEIYCARNQIELYHFGIERRWPTPNLLNYGHSKPSSNLFLSSHEINSFSVLESIVKDALELLLDVRNHPILVTDIDSASHSASHSTVYSVNQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0Z4</accession>
    <name>A8Q0Z4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731104.1">
        <property type="nucleotide sequence ID" value="XM_001731052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0Z4"/>
    <dbReference type="FunCoup" id="A8Q0Z4">
        <property type="interactions" value="1071"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0Z4"/>
    <dbReference type="GeneID" id="5855411"/>
    <dbReference type="KEGG" id="mgl:MGL_2103"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2103"/>
    <dbReference type="InParanoid" id="A8Q0Z4"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="49"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="172" mass="19011" checksum="D64706AC7BC86B00" modified="2008-01-15" version="1">MNIPKWFVKPLNHGLVRHASSRSGSSSKYLSRQRHDQFVRDRKADGTGYVSRSAYKLVQLSTKYPFFQPGRVVVDLGAAPGGWSQAVLQQCPKARVYALDLLPLQTSLPNLTFMRGDFRDTQVRTSLSSLIGQDVDVVLSDMMANTSGNSIRDTQASLDLCMAAFVSVATIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1A3</accession>
    <name>A8Q1A3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730758.1">
        <property type="nucleotide sequence ID" value="XM_001730706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1A3"/>
    <dbReference type="STRING" id="425265.A8Q1A3"/>
    <dbReference type="GeneID" id="5855065"/>
    <dbReference type="KEGG" id="mgl:MGL_1757"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1757"/>
    <dbReference type="InParanoid" id="A8Q1A3"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="422" mass="45789" checksum="04396C7CAD3CE43F" modified="2008-01-15" version="1">MTQDALIREALEMEEENTRSLLHYLEQEEERKTRQRQAGKKELQGPFLRWISVGLLQNKFVSQVEGTHGQASSKGQEVRKEKAKQGESKPGQDAPPPLSDEQSQDTPSSHPSHELDKKHFEQQGILPVQTRSNESSTPTTVHSNPPPDTLTLQDSGSATRSDVGLAADPHPSPHSIEVPTEGNAEACQAIQSQHAPDPNLKPSTSSSVHSDQTHPFIHTPPTRQCTTPPVSVTTQREPNDTQDSLSTSTHAGTPSQTLADPAANASSSAQSHGDALSHNNEALVNQDTPVDNSRATRPVADEITARTLISLHGLEPDATWVDEFRYLLGDHCAWDRIPFVPSRNRPFRPRQSTCVITGLPARYRDPRTGIPYATTEAFAMLRRILAGEFLWTGSPQSGVALSAGCYAAAHGDGGAGGVFLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1Y7</accession>
    <name>A8Q1Y7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730860.1">
        <property type="nucleotide sequence ID" value="XM_001730808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1Y7"/>
    <dbReference type="STRING" id="425265.A8Q1Y7"/>
    <dbReference type="GeneID" id="5855167"/>
    <dbReference type="KEGG" id="mgl:MGL_1859"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1859"/>
    <dbReference type="InParanoid" id="A8Q1Y7"/>
    <dbReference type="OMA" id="ACDKNRI"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="307" mass="34609" checksum="6196DB33589328C0" modified="2008-01-15" version="1">MNAANVSTAVEQGEMPLQLDTGLLASVDVNPMDIRKYMKDTEALLQARTRNSTQHLINTIFQLPIERHATYGPLASLPEFVTQLPREKPLPKPKPLTKWEKFARAKGIVKRKKDRLVFDEERQEWVPRWGFQGKNKDLENQWLVEVPSNADDDFRPDKAAAKERLDRRKKNEQQHERNLARQSGAAAAIPSGSTKGKSELGSGKASMSSRRRAELESEILRARNSTASMGRFDKHLEGETKPRGVKRTFQPNEIDARQERAANLSVLARLDKGSTDSEMNMRKAIKYASQAQGSKALAQKAAGKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q212</accession>
    <name>A8Q212_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730871.1">
        <property type="nucleotide sequence ID" value="XM_001730819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q212"/>
    <dbReference type="STRING" id="425265.A8Q212"/>
    <dbReference type="GeneID" id="5855178"/>
    <dbReference type="KEGG" id="mgl:MGL_1870"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1870"/>
    <dbReference type="InParanoid" id="A8Q212"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="160" mass="16806" checksum="96D306238C2A4609" modified="2008-01-15" version="1">MDLLVAAYARSEGVRIDGRRILVDVERGRTVPDWKPARLGGGLGGQSRKPKQKVRPDSFRGVVGGRGGFGPAGGGGGGGRGGGFRGGRGGFRGGGRGGAGGGFRDRGSSFRDRGGDRFSRPRDHSYRDRDGLHDASGSLSYGAPGPARSYEDRAPKRMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2A8</accession>
    <name>A8Q2A8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ap4A phosphorylase 1/2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730727.1">
        <property type="nucleotide sequence ID" value="XM_001730675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2A8"/>
    <dbReference type="STRING" id="425265.A8Q2A8"/>
    <dbReference type="GeneID" id="5855033"/>
    <dbReference type="KEGG" id="mgl:MGL_2181"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2181"/>
    <dbReference type="InParanoid" id="A8Q2A8"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="226" mass="25424" checksum="18238FBB235683A1" modified="2008-01-15" version="1">MNRAWNTAIKQPRVYMSSARLGNLSELVRSQYQKAIEAGDAFFYDSQVRVTKSGASQDGERQKTVPWQIRTVPALLKKPKAEPSSTASDEKKEIHHQPMQNQRDVFAPPYVPNLLVKELDNFTVLLNKYCVLPGHFLLVTRDFVKQEKPPSPEMLSLVYNIIMSHTPTRPDAELLGFFNCGPNSGASQPHCHFQLVELTPTDPDSKAVPIETMLETDMSPDENKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2Y1</accession>
    <name>A8Q2Y1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_2267</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730471.1">
        <property type="nucleotide sequence ID" value="XM_001730419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2Y1"/>
    <dbReference type="FunCoup" id="A8Q2Y1">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2Y1"/>
    <dbReference type="GeneID" id="5854778"/>
    <dbReference type="KEGG" id="mgl:MGL_2267"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2267"/>
    <dbReference type="InParanoid" id="A8Q2Y1"/>
    <dbReference type="OMA" id="TRIDGPH"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="423"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="935"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="956"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="966" mass="103680" checksum="79E943DCC0B09125" modified="2008-01-15" version="1">MTVPAQKERGSVVSVRASKSKANEGNESMDIPWISLQEDAVSHIPPVLTRDGSYLFLVQDSSVLIVSRITNRVVATLSDATMSEELRHTAPITGMMLSLFNPLQLITCSLDGTVKVWDYLESQLHDNVHVGHPIVSMSASSHWRNRLFVAVSKHGQQAAGPSSDSKTKEASSTIYSVQLGRGLSRAHKAAKIVRLGKMRPVSHLALSPDGRWLVATSSAKLHVLDLNDTGAGFTKYSTESRFTSLAFHPSKDLVQFATGEMNGKIKLWHCLEPPATTSAKLVPSMVSSGSLEPISPTTTLHWHAHAVAALQYTPDGAQLLSGGEEGVLVLWKLLSGTAAGSDGREFVPRLGASIMSLAVASGYENSEQEYVAHLADGSVVFIASLSLKPTRVFSTIKCDATRALLPLHERAKLPQPLALDRAAGHLVLLAGHPSTVQFVDVATRTHIRDMEIVPSNRVSRPEEALLSPPSVYAVAFSDPGRDALHAEWMATVDGRDGGSFTSEFSLKLWQWEPRSKTYVLNTRIDHPHEKSVSSIGFSPCLSDNDPLQAFLLVTAGGDGQVKTWRLALRSLKGARSEHFWVCRSSFGYRESVPHHVSWAPDGSLFAVAQGLFVTIWDPQTLVMQARLATPEIKDVRTCDFVGRKGRFLAVTGSPSRFVIWDLISQSVVYSASGSFYAQVKHGDRVLALRSTHAGTAIDLVCPRDRRIVRTYMVPFLLHDAPVNASRSSSLDDLALYGARQHGALVGIGAAVAAVATQSRSHAAMSLHSVALSDARSTLFDELFGVADSEKKKTESVLVSDAQYKQQLASDAPASAVLELFATPPHLLPPMSTLLDPFVDALFPPRSSTSAEVTSEAVAPHLTGGSSIALGTAPSSAADHAHPTDASFAIGSDVVPDGHEVPTRLDALDHVAQARDMDISHLTAVFDQLMSTATSATTVPVSSLPSRAPKSGTGASGKRRTSRSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2024-01-24" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2Y3</accession>
    <name>A8Q2Y3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730472.1">
        <property type="nucleotide sequence ID" value="XM_001730420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2Y3"/>
    <dbReference type="STRING" id="425265.A8Q2Y3"/>
    <dbReference type="GeneID" id="5854779"/>
    <dbReference type="KEGG" id="mgl:MGL_2268"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2268"/>
    <dbReference type="InParanoid" id="A8Q2Y3"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="485" mass="50040" checksum="A680ABF40D2C6FBC" modified="2008-01-15" version="1">MIIMIIVPEAPVVMEEMGVLVAPADAAATDHPAKAKTEVMEAMGVTEVLAVPATLAKAAHEATEAMEAMEAMEDLVAPAALVAQDAMGATEAMGDLAAPAEKEESAATDRPSNAATDVMDETGAMEDLAETVDAEATGPLAYDAAEETDVMDAMEDLMVLETPGTLAQAAREVMEVTGVTEVLAVPVTLAQAVREATEAMEAMEAMEDLVVLEAPVTLAQAAREVMEVKGVTEVLAVPVTLAQAVREATEAMEDLAAPAALVAQEATVDPAETVDAEATGPLAEVAAEETEVMGAMEAMEDLVAPAALVAQEAMGATEAMEDLVAPAALVAQEAMGAMEAMEDLVAPVNLVAREATGAMEAMEDLVAPAALVAQEAMGATEAMEDLVAPAALVAQEAMGAMEAMEDLVAPAALVAQEATVDAEATGPLAEVAAEETEVMRVMEAKEVLQIEAPCHQMPARLQLGVQSLQVQPRTKTLRSRRTHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q357</accession>
    <name>A8Q357_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2316</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:31240"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730520.1">
        <property type="nucleotide sequence ID" value="XM_001730468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q357"/>
    <dbReference type="FunCoup" id="A8Q357">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q357"/>
    <dbReference type="GeneID" id="5854827"/>
    <dbReference type="KEGG" id="mgl:MGL_2316"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2316"/>
    <dbReference type="InParanoid" id="A8Q357"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000008">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="14">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="354" mass="39566" checksum="40A75416B0CA71D2" modified="2008-01-15" version="1">MIEFRKIREQFEFFECCRDPEVASEITVQPVRRYDRLLDAAVIFSDILVVPQAMGMEVEMVPGKGPTFLHPLESPKDMARLKKVDIQKDLGYVLDAIRLTRTKLAGRVPVIGFCGAPWTLMAYMIEGGGSKTWEKAKRWLFDYPEESKALLDRIADVCASFLVAQILAGAQLVQVFDSWAGELTPYDFRTFALPYLRNIAVDVKDNLALKSVEPPPMIVYARGAVNHSLVEISRSGYDVVGIDHTVEPAWARQCLAQAQSSNRKFSEVEVNKGAQHRIAIQGNLDPAILYARPEVIQDRVRRMFQTKTGGFGGQGALICNLGQGITPGVDPDHLRVFLEAVHRVSKEMADNNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3A2</accession>
    <name>A8Q3A2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730549.1">
        <property type="nucleotide sequence ID" value="XM_001730497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3A2"/>
    <dbReference type="FunCoup" id="A8Q3A2">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3A2"/>
    <dbReference type="GeneID" id="5854856"/>
    <dbReference type="KEGG" id="mgl:MGL_2345"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2345"/>
    <dbReference type="InParanoid" id="A8Q3A2"/>
    <dbReference type="OMA" id="TRRMIPE"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="576" mass="65283" checksum="A0428259613806C0" modified="2008-01-15" version="1">MRLELLNDSRLEAGREFVPIKRLGTGSFGTVFVADWHSPLPSGTMVPAMQHSYARPEYVGKRIVAIKRMIRPYSTLEDCLSLNELHALIALPPHENIIALYDVFRKPISQELYLVFECMEGNLFQLMKSRKGRPMAPGLIASIIQQSIAGIEHVHSQGFFHRDLKPENLLITTTGLGEYPLSKSQIDGTKQDVLVVVKVADFGLARKMEENATFTTYVSTRWYRAPEILLESQKYSSAVDLWALGAIIAEMVRLEPLFPGNNAMDQLQCICSVLGAPTNDMHLPLSNGSLWPAWLDVMQQWERSVQPLSPVSLERYFPFPTSDVLLDFIFHILRYDPADRLTARQCLQHPFLVNEAPKLRPTRRMIPEPTHHPPATALSYDTDSPYESDSVGSPEGALEAVRDTPPKSELHEHSDVMKRLNFAQGDNQYVLFPKSSLLHRSQVSPGSRSNSPLFFMHTRKKTQESTRSMTEAIAASPSACTMTPPTLRPKSEGFSDRRPSFFSERHESGHLSSGTLLRRGKKDPVEKETKEMERKRREDEKAKLRERSRAVVQNRVNMMQDQGLKTHSKRWVDIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3D3</accession>
    <name>A8Q3D3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730569.1">
        <property type="nucleotide sequence ID" value="XM_001730517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3D3"/>
    <dbReference type="FunCoup" id="A8Q3D3">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3D3"/>
    <dbReference type="GeneID" id="5854876"/>
    <dbReference type="KEGG" id="mgl:MGL_2365"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2365"/>
    <dbReference type="InParanoid" id="A8Q3D3"/>
    <dbReference type="OMA" id="KSGPIYC"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="342"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="503" mass="56558" checksum="7DCDD4A6E90DC36C" modified="2008-01-15" version="1">MTPPKKRARVAEFSAESPKTEEEADRHLQAALKASVQRVTCPLCHVEWPESEIVRHASSCGTESASKEVEKQWKAILPGLSKTHNRRIPFFKVLDGMPLAVDAFRYGAIEGCTAYFLTHFHSDHYAGLSSTWKHGPIYCTPATSRLVHAKLRVDKMWLRPIALDVRTLIPDSGGVYVTCIDANHCPGSCLFLFEGPLTAHILPSSIRNPHIGTSRVFRYLHCGDFRACPAHKTHPALQLGILDAIYLDTTYLDPRYCFPPQAQVVQACIDLVVMPHAQPHDVTLMSAWLKQPQVRSQPLVVVGSYSIGKERLFLALAKALDSCIYCADARKYETYALLDDPTLQSRLTKDPMSARVHVVTLNALSLDTLRAYTETFVRRGMSISHTIAIRPTGWTFSGRSLAPKKSIDDLVKECVPPTFTYKQLEPQRQSTHAVRIYAVPYSEHSSFYELMALMVSLPHRRIIPTVSAGNQARRQAMRSWTDMWTAASTQQHVHIAPRSEDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3J4</accession>
    <name>A8Q3J4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_2422</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730626.1">
        <property type="nucleotide sequence ID" value="XM_001730574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3J4"/>
    <dbReference type="FunCoup" id="A8Q3J4">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3J4"/>
    <dbReference type="GeneID" id="5854933"/>
    <dbReference type="KEGG" id="mgl:MGL_2422"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2422"/>
    <dbReference type="InParanoid" id="A8Q3J4"/>
    <dbReference type="OMA" id="WMMGIAY"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="309"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP43412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="634" mass="71918" checksum="2A918038A105F757" modified="2008-01-15" version="1">MSMESFRNLHSHSDDPRWYKPNDEEMHQAQIIEPWSDNIRHAKYMSYIYCACILVAAILHGFRLLREQYPRIVLYTSKIPLIPSCVALCRMVGYARIKIGPWRLPAGRYLVICGCFILGTVVWCFAMTPHYRPHNEVGSPPLAIRAGMMAVGMLPFIFALALKLNPISLLSGVSHVHLQYYHQVSSIMFLFFSIVHTVPFIWQPLREEGFERLNFVWHESYKTYWSGTVAIFFLLWICASSLGIFRHMSYEFFVVQHIVTFTLMLAFLFVHVEDLLSSHVWLWAAVGIWLFSVIGRSLIVLFSTDFFVGARSQVRVLASVGHSPGIVQDQPAKFVRMSFNTPLRWHPGQHVYVRFPGMAVTQAHPFTCLSLPSVSPHMPNRLVLLARVHKGITQRLHDHVLTFGQRATKSSMLFRNFSLDADSADSGKTLAHDMGHEKESLAPDEYVMSFMAALDGPYGYSFSLGTYEHSVLIAAGSGITFCLPQVSELVRRAAHSPRSYLTRSVRLVWCVRTLDMVQWVRPELLELVFHASNVPFKVSIELYATREQNNVADADLNAVLNIHVGVRPNLHQILNNDVDLAMRQESTSLSVSVCGTPSMNFDVSRSVSYMNWCVARGSLGSLRDIHLVSESFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3K9</accession>
    <name>A8Q3K9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730639.1">
        <property type="nucleotide sequence ID" value="XM_001730587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3K9"/>
    <dbReference type="STRING" id="425265.A8Q3K9"/>
    <dbReference type="GeneID" id="5854946"/>
    <dbReference type="KEGG" id="mgl:MGL_2435"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2435"/>
    <dbReference type="InParanoid" id="A8Q3K9"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="91" mass="9644" checksum="CD29489C1C447176" modified="2008-01-15" version="1">MSFFNNIGRSMGIPSRSKMRYVPPPSSSLERPYGTPPPSMVSGSVPGGAVVAGGSMNLASMPTKPLYLCQPFVRSTLIKGSFRTIVALPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4N4</accession>
    <name>A8Q4N4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730203.1">
        <property type="nucleotide sequence ID" value="XM_001730151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4N4"/>
    <dbReference type="FunCoup" id="A8Q4N4">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4N4"/>
    <dbReference type="GeneID" id="5854700"/>
    <dbReference type="KEGG" id="mgl:MGL_2585"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2585"/>
    <dbReference type="InParanoid" id="A8Q4N4"/>
    <dbReference type="OMA" id="QPRANGC"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="155"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="617" mass="68383" checksum="1FCB47DE95D1265F" modified="2008-01-15" version="1">MGVPHTPPDAAGGALPSKTGLQHSEFGLCKNEAYRWTSKYDESRLEVSEEDSPSYLTVLSTYLTYIVLILYGHLRDFLGRRFYPQDFSHLQENNGYAALNSDFDSFFTRRLKMRIDDCFERPVTGVCGRTVMTLERITRNYNRTFELTGNTRRALNISAYNYLGFAQSHGECADNVDIGLSLYGLSSGGTRLGAGMLDLQRQGERMVARYLNQEDAMLISMGFATNSTTIPAIAGPGTLILSDELNHTSLRAGVRMSGASIRTFKHGSIDALESLLRECISQGLPRTHRPWKKIVLLIEGLYSMEGTIVDLPRVLELKKKYKFYLYVDEAHSIGALGPHGGGVCDYFGVDPSLVDIHMGTFTKSFGAVGGYVAGKKEIIDSIRRYNYSNVFGETMAPPVLIQIMSTLATIMSVGKIPDGRALLPPWMQFSEPFLAGVEGRHRLERLAFNARYLNHGLRKLGFIIWGSRDSPVVPLLLFQPGKMKLFSSFMLDRGLALPPSQRWKTEDDAWNTATLETPNLSHTGPHGVRRRPPIVVVVVAYPATPLISTRVRFCVSAAHTKEDIDDVLVACDEIGSAICLKYTDGGPGGRWSIDKILSHATDLVAWNGIDPLPEPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4T3</accession>
    <name>A8Q4T3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730249.1">
        <property type="nucleotide sequence ID" value="XM_001730197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4T3"/>
    <dbReference type="FunCoup" id="A8Q4T3">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4T3"/>
    <dbReference type="GeneID" id="5854554"/>
    <dbReference type="KEGG" id="mgl:MGL_2631"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2631"/>
    <dbReference type="InParanoid" id="A8Q4T3"/>
    <dbReference type="OMA" id="WCGDDCL"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="322"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="568"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="702"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="916" mass="101942" checksum="220636243BA453EB" modified="2008-01-15" version="1">MAAQWQKLGDAYYRRTIQYELGWSVQRLDEFLVASSADMGWIALTRDPEQLVALGDTSAMEPKIQVYTGAGQLFETLPWDAHARIVGLGFTWRDELVVVADDGHVRFYSWLVPYHHPQQHSGGMSCIEATPTSYYQVHTLGKEATELGVAGVLIEPKHIWVLLRNGSLIDAPLTSDDMSVWSEMPLTIDTHVLPPLSTPRPSLYAWTPFTRHGDARLFLSTDTSAWSVHRFDGYAKEAYEDGPMCAVSFSPNGKLVAWINERQELIVDTVGPSRRRLRTWDITSAHAYQVAPLAFRTRKLLEDADLVATPTDKGGFAASGVHAMTWCGDNAVALAICDHVLLVGPHGEPMDFPVRGIPYLFGSHDGLHIVHRDAHEHIGKVEAPTLRALRPGSTHIAAILLDASRLAQRHRPQAYEAVRTIQHELASAVDTCIEAATYEWLVDTQTALLQAALFGKTFIDTYEPTRFLHVARLMRVLNAVRTPWIGIPASFDETHVPNLLYRLASRGQHKLAVRMCEHMGVRPDAVLKHWARAKVARARPVGLHGDTARDERLAHLIIDKFQTAGTLRYADIAMNAWHAGHPRIATLLLDKEVRACDQIPLLMHMQEYRLALMKAVESGDTDLILHVILALQSSLARGAFFRIVQSLDWPSLPPPSQDAQKVAAAAAATTTTTTSASATAVKAEPTDVVGLRPTSLPTYTTLAPRLLVSYGRDYDRPLAHDFFYQDDRHADMALLCIDDALQMDASVRAGALRRAQRHFGEDRTCASEARLTDETCSLLGVQVAIQAELNIADTTGRPPSQVQGMSLFDTILTCLKHPKLEKRAEKLKHDFHVPEARYYALRVRAYIATQDFHSLWRHVTSRRPPHGYVTIVQALVHAGHVDEASRYMNRGVTMDKANRAKLMYVCENGGQKHGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4W4</accession>
    <name>A8Q4W4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730274.1">
        <property type="nucleotide sequence ID" value="XM_001730222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4W4"/>
    <dbReference type="GeneID" id="5854579"/>
    <dbReference type="KEGG" id="mgl:MGL_2656"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2656"/>
    <dbReference type="InParanoid" id="A8Q4W4"/>
    <dbReference type="OMA" id="DTNPGKN"/>
    <dbReference type="OrthoDB" id="3344538at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="85" mass="9689" checksum="C6A648CEF3D87021" modified="2008-01-15" version="1">MYQGSCFSSLGGGNKDKSLNRTETSRGNELHRTTSSYQGSVADGMRYSDNHRAQDREHLTASQAYKSKTLEERIKQAERENRSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Y1</accession>
    <name>A8Q4Y1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Golgi apyrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730288.1">
        <property type="nucleotide sequence ID" value="XM_001730236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Y1"/>
    <dbReference type="FunCoup" id="A8Q4Y1">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4Y1"/>
    <dbReference type="GeneID" id="5854593"/>
    <dbReference type="KEGG" id="mgl:MGL_2670"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2670"/>
    <dbReference type="InParanoid" id="A8Q4Y1"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="688"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="714"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="206"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="83104" checksum="C7E88D6E2648AC3A" modified="2008-01-15" version="1">MTSDMNDAFDGHHERKYAVIVDAGSSGSRLTVYSWENVAQERATRLAYGWPLDVLPRVELGAGPSHTHAALSQIKIEPGLSAFEGRTHELRAYLDKLLAHVRKIVPTEALPQTPIYILATAGMRLLKPEAQQAILLETCRIIREQPFYFEPSSHDFLGADTNSACDGYVRVISGEEEGLLGWLAVNYLMNEFRPSERTYGFLDMGGASAQIAFEPPIQSSMQQNLFEVPLHRLDSSVDTHRVFVTTFLGFGTNAARTRYLYALTERLGLHPTYEDPCLPKGLHLPLQDGTRVAMGTGSYAECLSEQLPLLDRHAECREPPCLFHGVHVPPIDFQSSSFVGVSEYWYSSDDVFRLGGMYDHDQFHSAATEFCASDWRDLESKLQRHQYPEQLTLSRLQMQCFKAAWMSTILHEGLRLPRVSNTSSFQSINHVRGLSVSWTLGKALQEASRDVEMSQFPPVSSRKAVVSNAITIVLLVMVCIAICVVWRRMYRRHGRWTPLSTKGGDDDDRAEEHSLVVTMPEDSHVAEEQTCVGGGSAAGTKAGSGGAPQGFGSLGPENVYEIDRCDDNEHGQFTPHSLDETTLFVSQPASSSRRSSTVRAIPKQARLGNDDLELSDPSSPLPGRRGSLPPRVRTPGVPLTASPRLSPRSSHWIRPNSRIDPSVLLSPLASTHEKDSTSDSYVIATAVAPSRARSPAPSSATHIPVPIDPRPSPVASTRTSPSHLSTTPNQAEFRGRVSPGPGASPRDKSPKFLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q571</accession>
    <name>A8Q571_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730357.1">
        <property type="nucleotide sequence ID" value="XM_001730305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q571"/>
    <dbReference type="FunCoup" id="A8Q571">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q571"/>
    <dbReference type="GeneID" id="5854662"/>
    <dbReference type="KEGG" id="mgl:MGL_2739"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2739"/>
    <dbReference type="InParanoid" id="A8Q571"/>
    <dbReference type="OMA" id="AASLRWY"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35542" checksum="71F03ADB31D0EB8E" modified="2008-01-15" version="1">MLQVLLALVDRVISPDQYGTLLAGVIVLALVHSWAKGPSLLGREERLEAYQLRARDKDSKAIVTAGLNEMAGRVVLVATGGMTPMGLVVIAMLAQQGAHIVVLVPDLSSLDVIQMVDLLRESSRNENIFAESCDMGDMASISEFSKRWFTGKMVQVHPEGTSTAASAVHLPGIPTTEAHRLDTVLFLPMPEGSTPMGSSPDQSYLYNVLGPFHLVESLLPSLQQQPLSRDVRIVSAISPWYAAGMARFDSVMKTNSRAVFEPWTFTGASSLHWIILAKEWQRRFDMIASADQRPRTRVPGMDAEEDSAPVSARRSHISSVLYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q610</accession>
    <name>A8Q610_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729853.1">
        <property type="nucleotide sequence ID" value="XM_001729801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q610"/>
    <dbReference type="GeneID" id="5854160"/>
    <dbReference type="KEGG" id="mgl:MGL_2839"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2839"/>
    <dbReference type="InParanoid" id="A8Q610"/>
    <dbReference type="OMA" id="TWERELH"/>
    <dbReference type="OrthoDB" id="2351920at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="313" mass="35225" checksum="BB4B4BA953CBE3E0" modified="2008-01-15" version="1">MAYTRKNTLSAVASGSVHAKSAIEPQDDDDNDDEHLPYTIEADGHVELAPHLQLRAQINSTTTTPTWPFKRYGPGPCGRSYAALFRSHDNDLHPDVSVWADLALEELVPRTRPDSYSLPSSLMHPYTQTSSGMRRRARPSGIPPSLGLKTSVQDDEWLHSEEHDVLIDQSTAVDEQVVDQDRSFERELEEWTASEMSKNAHNDDYFGAQYPSVRNRQGVSSSTLPTSSDMAEQQEFCHAILSVIAQRDTFTRQKRQRANSVSPIHSQPSRRKRRSLVPPDAQTDRTTAAAAQLPPNERRWVWGQSRSLREPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q671</accession>
    <name>A8Q671_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729881.1">
        <property type="nucleotide sequence ID" value="XM_001729829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q671"/>
    <dbReference type="FunCoup" id="A8Q671">
        <property type="interactions" value="711"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q671"/>
    <dbReference type="GeneID" id="5854188"/>
    <dbReference type="KEGG" id="mgl:MGL_2867"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2867"/>
    <dbReference type="InParanoid" id="A8Q671"/>
    <dbReference type="OMA" id="PVHYNET"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41621" checksum="15A2722503BBBAE0" modified="2008-01-15" version="1">MSEVDLSKSQSHAFTDLAAQLRKDSEDSAQLVQKLSESVRNADFDHPEGLSLLTAKVDALLAYIQNLALLCVQRLSGNTLSQEPGALYVQNLVRLRLRLEKMRPMEARLKYQVEKLLQAAVAVERESSQRVATDGGADAEAADEDMDLLSFRPNPEGLAPAQVGRQESRLPNEDADATEGVYRPPKVAPMVYDPDAHVSRKARNKDRQPSRNTALLADLSAGMSTNPYETSVAGVGGDLAVGTAGSSRARALRRMQEFEEDNYKRLSLNKKDAKRRRRDEQDVALGGLGLSGRGNRLSGGVEEEFGDLLRGSERDARRRERGDDRDAYHALQKRAKRPTVTAQAKQHADMHTSLASGSGSARQFKKAMRKQRQKTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6F4</accession>
    <name>A8Q6F4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729964.1">
        <property type="nucleotide sequence ID" value="XM_001729912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6F4"/>
    <dbReference type="GeneID" id="5854271"/>
    <dbReference type="KEGG" id="mgl:MGL_2950"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2950"/>
    <dbReference type="InParanoid" id="A8Q6F4"/>
    <dbReference type="OMA" id="GMERSMT"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="62021" checksum="C788A7F5D22C5617" modified="2008-01-15" version="1">MAPRALIDQLPLATRYAHFQLVLQIHELLNVPVLSGEFSVVYKIKHAVQLPRRRANSETAGSDVASPADDVLQNGSIDSSMNHATIETGQDSTASASASTLSAASVSIPASLSTRNDTIVPNNSDDSPNTTLMPSAFPKGSAQRSHTLPLAGDVHSTPMSSTLPQFGSTEELVASPDSSVLSLDHLPSAHGSAVDETTSVASPSMNRRGDARLHPASTMSSMSGFSMGPNKIIRSTTTFEGVQHHTVKWEATAQTDVRIGINRHLTHLDRETEAGHLHSSALLLTVWWRQPDDPPDTRRRFGQIKINLAEYAPGMPPSPSERIESRQYLLDKCACNALLRLSIDMRRLDTTHSYRVPRIKQGLVDPANAIMQGRSASGERDAIYASSQREPELMHGLEWHFKLPLPMMFNIAAVRPEFLNASGRRECTSSNPNSLMHGFSRDASQPRHEFCQLNSVALVDELVQGMLGPTVDQRAESHDDEDASSSSRSPRSQKIRSRWKRIIETVAGTHHTNPHRSFSGSDAASLRRELRPRVRSDQSKRSIPLPPLHMRFKNDDDSDPAPNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6H1</accession>
    <name>A8Q6H1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop14-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729979.1">
        <property type="nucleotide sequence ID" value="XM_001729927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6H1"/>
    <dbReference type="FunCoup" id="A8Q6H1">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6H1"/>
    <dbReference type="GeneID" id="5854286"/>
    <dbReference type="KEGG" id="mgl:MGL_2965"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2965"/>
    <dbReference type="InParanoid" id="A8Q6H1"/>
    <dbReference type="OMA" id="KSCWPSL"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="936"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="936"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="953"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="964" mass="108298" checksum="C3D20B785D52F323" modified="2008-01-15" version="1">MGSGKKGGSQLAQLRSGLRDAGITGSNSKKGKRNDRDDSRVGQYRAQQRRKRLEALMTNLNAFDERVASSKNQALGAKVKGASGRPANAKSSSIQQRRERLLPEYQNRHHSSSFHDRRFGEYNPHMSLEDKMLKRFTHERMHRIPKTSNTSLFDLNDDDDADLTLTHYGQSLSGMDELPDVRLDDDNDDDNPRGHIDANMTRDEHFAGFDDAEDPDAAQAPRSKHEVMKEVIAKSKLAKHERQKVKDADEELRMELDDELGDIRSLLFSRPSTETSVDVAATERAATPASSKGDTYDAFVREMAYERRAKPQDRLKTAEELAQDQAKRLEEAESARLRRMRGELDEEGEALMDYAIDDDDDHENDANSNVKRAVKTDEPRTMRSRFGLGHGLDEQSSAASENDEDAGQDTETAMEEEYDVDEEEDNESDDDEGDDAEDSADNDEDGDENDTAAQLADYQNLEQYGEAPYTPQTVNKAEPQPTRRLPRASSERVSTLPFTFPCPSTHDAFLDLLEQHQVAPSQLHTVISRIRTLHAPNLGEENPVKLQRFLGVLVDHVLYRTSQDDATNEDLLVLNDLVLHISDLATMYPLRAAEHFVAKLSLMQRNLMQGLAQGALEPASRTWPSLPELSFLRVCGLLWPTSDRWHAVTTPMLLLVAQYLAHARIRSLRDMGSALYLVSLVSSAQRESRRIVPEALNALFNISAMLLPLHHGRRMHGRSPVKALAEEFGIPTPDVEAQHTHAFTIRADAQPHAKVSLAHILTHADAVSSSSAVQTQVDLLRMCVALQMSFAKMYEGSPAFVELFMPMLFLLEIGEAGLRDTAPSVVSYVHDAATSIRSQLERAYASRHALRLQAHRALSIATYAPKFDQQSFDPKRATDPDTERAYAAKMRALLKKERKGAIRELRKDAQFLADEREQRRVAEDVAYKKKIDKILGGMQDERSEQKQLERAKSAIRKRAGKRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6I9</accession>
    <name>A8Q6I9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729994.1">
        <property type="nucleotide sequence ID" value="XM_001729942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6I9"/>
    <dbReference type="GeneID" id="5854301"/>
    <dbReference type="KEGG" id="mgl:MGL_2980"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2980"/>
    <dbReference type="InParanoid" id="A8Q6I9"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="463" mass="51257" checksum="0095B7C113F6D5A3" modified="2008-01-15" version="1">MSSTKWADESAPVLPPKTRKGSYGLIPRLGRSKKKESVRLSQYVDPQIIQDEPDAADHSRLDVIDQLDISGLTGGTLFHHDSPYDACSPQFNRTDNNTAPINAFDRSVDPITNALLEHHKKREDGIQHQTPADDLDGQRTYANYDDPYAVPQSMGYDGPTDADNPNSVFYGVTSEPWQEFSRPVKEQTSPTQQQNPKPETKFEDMETILRGGRRTQPDVSTTSYKDPLDLSSRQDHLDVKSSSNPERKSPRSKSGTLSRSKSLLARFRRMRVDPDQSAESENPPSTPPLPVQEQQQQQWQQQHLSSQRPYVNLNAHGVAGPVTVDPAPTTTTLQNQPSIPTYQADSAKSYTMAPPIAAPMSNRQDPSSLGYDTSYAYGTAYSKPLRRGYSDASAPPPPPKNYPTVSSSSHPKSRSMRSSEKASSLSYMTHSDRAALNLEDSEPPARVLRRLATGGRSQPRPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6N9</accession>
    <name>A8Q6N9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730034.1">
        <property type="nucleotide sequence ID" value="XM_001729982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6N9"/>
    <dbReference type="FunCoup" id="A8Q6N9">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6N9"/>
    <dbReference type="GeneID" id="5854341"/>
    <dbReference type="KEGG" id="mgl:MGL_3020"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3020"/>
    <dbReference type="InParanoid" id="A8Q6N9"/>
    <dbReference type="OMA" id="ATCIGKD"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000028">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP42820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="250" mass="26786" checksum="9F5BDDD060987ADF" modified="2008-01-15" version="1">MSAGAGEGAYSFSLTTFSPSGKLVQIEHALAAVGQGTTSLGIKASNAVVIATEKRPPSPLVDDSAIEKVALVCPNIGIVYSGMGPDFRILLARTRKIAQSYWKIFGEYPTTKVLVQEIATVMQDATQSGGVRPFGVSLLVAGFDAVRGPSLYQVDPSGSYFMWKATAMGKNMTNAKTFLEKRYSDDISLEDAIHTAILTLKEGFEGQMTEKTIEIGIIGHATRATVGAGTELVPVFRRLSEQEVKDYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q727</accession>
    <name>A8Q727_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_3298</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729754.1">
        <property type="nucleotide sequence ID" value="XM_001729702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q727"/>
    <dbReference type="FunCoup" id="A8Q727">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q727"/>
    <dbReference type="GeneID" id="5854060"/>
    <dbReference type="KEGG" id="mgl:MGL_3298"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3298"/>
    <dbReference type="InParanoid" id="A8Q727"/>
    <dbReference type="OMA" id="LCDADNI"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="46"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="510"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP42540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="717" mass="77168" checksum="420183DC8888122B" modified="2008-01-15" version="1">MLRILAGRASVAHRSITTKYGRRRLLSTETPQTYIEKVVQKYAVDWDPAVRVRSGDYVSIRPATVMTHDNTGPVITKFRSIGAKQIHDPTQVVFALDHDVQNKSPKNMDKYARIEAFAREQGVDFYPAGRGIGHQVLVEEGYAFPQTLVVASDSHSNMYGGVGAVGTPIVRTDAAAIWATGKTWWQLPPMVKVELTGQLRPGVTGKDVIVALCGYFKNDEVLNAAIEFTGDGVSALTVDERLSISNMTTEWGALAGVFPVDDTTLSWYDALLRKMDKLHFQMGSSPRPSDTHPRLNWSHLEALEKHRIHSDDGASYAKHLRLDLSTLSPHVSGPNSVKVATPLYELEKQDIAIQKAYLVSCVNSRASDIKAAADVLRGRKVAPGVEFYLAPASSVVQREAENNGDWGSLLAAGARPLPAGCGPCIGLGMGLLKDGEVGISATNRNYKGRMGSPNALAYLASPAVVAASAAAGKICAPEGTRPEDGRPLVSMESIDSTPQAAAAPAELEPQFPPKFAGTLVFAPQDNLNTDALYPGKYTYQDDITPERQAQVVMENYDPSFASSIAQERARRADNGEDAAVVLVSGYNFGTGSSREQAATALKYAGVPVVLAGSFSDVFKRNAINNGLICLQCPELVDDLTSSYAKDGQRGAGGRQPGELSVLLRDATVSLDSRTGAVELRFGNGSVKRYTTRPAGIGRSIQEIYVAGGMESWVKQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7B3</accession>
    <name>A8Q7B3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729776.1">
        <property type="nucleotide sequence ID" value="XM_001729724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7B3"/>
    <dbReference type="GeneID" id="5854082"/>
    <dbReference type="KEGG" id="mgl:MGL_3320"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3320"/>
    <dbReference type="InParanoid" id="A8Q7B3"/>
    <dbReference type="OMA" id="AWCGRPY"/>
    <dbReference type="OrthoDB" id="5386199at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31126" checksum="CBC3ADDF2DBC71DD" modified="2008-01-15" version="1">MHSMLSCVRGAATRVSIAPKHMPPRCVRLDVRMLHHTPRWHEKSKAIAQYIGPMRTAYYRIKLFSLSSLSVAAVFAPVFLMCSHKMELAARVGIAATTLGASSVSTALISWIGSPYVGHMTLRRTNPNAAPLHYISDGAQDVVLDDTPSDPMRHASDKYYLEIATLSWHMRSLKTTVYAPSLLRATSRPLATWELPDLPAPLTVDSSDRMGDHTVSSLVAETVDVTSGKVVGRWWARWRITSTASTEPVAFEGTCESEGHPVRYFYVDETQLGDEWRVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7F2</accession>
    <name>A8Q7F2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729785.1">
        <property type="nucleotide sequence ID" value="XM_001729733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7F2"/>
    <dbReference type="GeneID" id="5854091"/>
    <dbReference type="KEGG" id="mgl:MGL_3329"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3329"/>
    <dbReference type="InParanoid" id="A8Q7F2"/>
    <dbReference type="OMA" id="SINQDFW"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725162" evidence="4">
        <location>
            <begin position="21"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="94"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="383" mass="41292" checksum="8DFC120E488CD4C5" modified="2008-01-15" version="1">MSKVLTSVLAILALGTLSLALDENAVRLQRSLRRNVHDSSSDPASVRNRVAAKYASNALSYFRNTGKHHPIYHGTMLSKRAGSSEIPLESESGWTAEVGIGKSVQTFNIVFDSGSADMTMNTGTYDPAKSTTSKNLQKTFSSNYMGGKADGNIFSDQVLLGHVKANDVSIGQATEQFMPGGDHVQGVIGLSFPSLSAFGTSSHTFPEALQREQDMDQNVFQFNLRDSDPSLIIGKTDESEVDGGFGWIDVSSQDGYWVVDAELNGKAVKGIVDSGTTVIIGNNDEVKEVLDKLDHVRVTKSERGEYQGTFQCDNPPRVSINIAGKEVSMSKEALTLATDGTNCQMSMLGMKGLNGWILGESFFQVASVVLDFDTPRIGIGKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7R7</accession>
    <name>A8Q7R7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729553.1">
        <property type="nucleotide sequence ID" value="XM_001729501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7R7"/>
    <dbReference type="GeneID" id="5853859"/>
    <dbReference type="KEGG" id="mgl:MGL_3097"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3097"/>
    <dbReference type="InParanoid" id="A8Q7R7"/>
    <dbReference type="OMA" id="QDPNAQW"/>
    <dbReference type="OrthoDB" id="3362023at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="923"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="974"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1075" mass="115909" checksum="B18194880EA56F29" modified="2008-01-15" version="1">MLAQHVEPLSPNLDAMMSGPPPEQTDTPRRSFRARVSDTIQRARGRSSPSPAPPAHESQHDTPSPSKTRGMGRFLRKSFDIARSSSPSPSRNKDVVYSYTAPAYEVPDLPDWQLYDGTSVPMNLDQLAKENDSLMPPPPSLGYHGAPQDGLNAVSSPVPPAHVHQGSLGVMPPPPPQPQFLPHPPTMIPPQRPMSMPPQLPPQMPPNMPPNMQPSMPWSGHEAGSSYAQEPGMQPPEEPLFGHVAPRSRSARVSLPPTLTASPPPRPSFATPSPAPPALPEESHARSPERPPCPVVPALQVTSSAPEDTAGEVSLVNAYADVTDGGTQDETVIDHRSPKERAGTPSVLGQASSRGSCDLETIELEDNVDTQGRHLGPNDAAMEEQKQQRILSAMEKAPEGAGLTDLMNRVVNPNRQSWLHGLWPRHASGGSEASKPASDRSSSQGGVIFRGADASPSIYSSESMDEMPERASVASPRTDRSASGPGDAPASDLYRAGPGLLRKNTAQSRRSCGSQSSRNSSQPSDDEREAFERRRRSNLQARHILETEKKLGMSTELQQAAWMPPAPMPPPPPAPTSPAPSMQSYRAQSRLSAGPGGTAVLDQVNSQTHEPAQANWQAQWQVHPASQESACADAPTQTPMYEGMRQQGVSEPHMQEDAQPAWQPTQQVYPDAAAQGTLNVQSQEQAYAQWQLQWNVHPEAAPQAPSEPVAQEQAQAAWEAEWQVHPESVQSGATRGPVPNQAQADWYAQWQGHPDAQWQGHPDVQWQGYQDVQWQGHPDAQWQGHPDVQWHRHPDAQWQGHPHVQWQVPPQAHVGVLAAPGMSPNEGVMPTHAAMPHVRRKAPPGSQPSHLPKPASPTPTSTFQRDSMPPPKKSAGAPILPDVVEDDESIIDEQGRRLKPDGFGGLQPVDDQSKEEAAIAPSPTMAPGAEAAAPVASQDTPRAPQVESMRTDFKPQNGRPPSSLSVHTPFVHNASSPRPSSPAVRSSAMPARKSMPASSSNGPPYQIAPELYTTPQSLHNKVGRMTWTPEVAEAAAKYIQTMTNSASRSQIHQHAKPHTGASRSPLPGAPEPLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7T5</accession>
    <name>A8Q7T5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729571.1">
        <property type="nucleotide sequence ID" value="XM_001729519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7T5"/>
    <dbReference type="FunCoup" id="A8Q7T5">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7T5"/>
    <dbReference type="GeneID" id="5853877"/>
    <dbReference type="KEGG" id="mgl:MGL_3115"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3115"/>
    <dbReference type="InParanoid" id="A8Q7T5"/>
    <dbReference type="OMA" id="HWHEITS"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF735">
        <property type="entry name" value="AFR153WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="495" mass="53097" checksum="3B63D5644695D9A0" modified="2008-01-15" version="1">MHTQKATHLFQSDASLSQGVERAAKARRTAHGATYGSPIWLGRGVKKQEAQVDFVQLAERAAGADGGAYKVISAHRPAGAFASSRSPYLWTAESGRIARCTNLETGETVQQLCGHMGPVSGVATLAIAPDRTLICTASWDRSIRIWPSTPGKPPCIALLENAASDLLKALHIDATHLLLYSGGNDKVVRAWDLSAVVSWAQSLSWDEWHALSVCAPNEPCPKPDLVGVLQGAHTRPIVCISTLPPAPQDAVAFGDLPPTGTLFTADSMGRILQVNMMREHCIVERELNGHETSVHAISPVWYECEHAGTWTADVWTASSDQTVRRFPLSMHDKAQRLPGRTSSAGGLLGSRPAVHATQLIPTPHKAHVVLPLGGLCGSEAGVGTEAMTSLLDDTEAVLLGMEGGTLQVYRPAPSVELEGHWHTVTYVGTWTSETRQVYIVSASLDGTIRRWPMQELVSCQRTVDTHEELGASASNAGSSVLTAEEEAELDELLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7Z0</accession>
    <name>A8Q7Z0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH:ubiquinone oxidoreductase 30kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729618.1">
        <property type="nucleotide sequence ID" value="XM_001729566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7Z0"/>
    <dbReference type="STRING" id="425265.A8Q7Z0"/>
    <dbReference type="GeneID" id="5853924"/>
    <dbReference type="KEGG" id="mgl:MGL_3162"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3162"/>
    <dbReference type="InParanoid" id="A8Q7Z0"/>
    <dbReference type="OMA" id="PCRKNRF"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="9">
        <location>
            <begin position="94"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="275" mass="31899" checksum="7FAEDD667B0CFC61" modified="2008-01-15" version="1">MATAARTLLRCARPAVRQAAYVPCLRTISTSLALREQGDKVMLKSPYLERANMNPMDKYQSMQGPLHDYGSWVLSVLPRFIQQFSVYKDELTFYVAPAGLIPTMTFLRDHTLTQFKVLMDISGADYPTRSQRFEVNYHLLSIRNNARIRVKTYADEVTPVPTVTSLFRSADWFEREAWDMYGIFFAGHPDLRRILTDYGFEGHPLRKDFPLTGYTEVRWDEEKKRVVYEPVQLMQAHRNFEPASAWEQVGEGVSYTPNEYKLVPPKPAEENKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8C9</accession>
    <name>A8Q8C9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_3248</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729704.1">
        <property type="nucleotide sequence ID" value="XM_001729652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8C9"/>
    <dbReference type="FunCoup" id="A8Q8C9">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8C9"/>
    <dbReference type="GeneID" id="5854010"/>
    <dbReference type="KEGG" id="mgl:MGL_3248"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3248"/>
    <dbReference type="InParanoid" id="A8Q8C9"/>
    <dbReference type="OMA" id="IKWPAYF"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="127"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="387"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP42490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="443" mass="49986" checksum="934640D9F8CC3DC3" modified="2008-01-15" version="1">MGTKMWLEPPRTCLTKRVLGRRDAGEKAAANAASQQEQQAQSATSQSSLLPLAAQVQPDVSQQSKNNNVDTVESGSKSTQGFSSAQSSISKPTPTTMPGVPASAPDMNMYTGLPMRNLKGRYKLQDFTILRTLGTGSFGRVHLVQSVHNQRFYAIKVLRKQHVVKMKQVEHVNNEHSVLSMVRHPFLVNLWGTFQDPTFLYMVMDFVPGGELFSLLRQSRRFPSQVAKFYISEVALAIDFLHKHNIIYRDLKPENVLIGADGHLKLIDFGFAKVTAQSNGMCWTLCGTPDYLAPEVIRARGYNASVDWWSVGVLLFEMMAGYPPFYTEDGNPIKLYEKILAGQVHYPSFFEPGAKDLLQSLLTADLSKRFGNLHRGSRDIFAHMWFAEIDWECLYRKEIPAPYIPNINMDGDASQFDKYPENDLSEYQRPNAPDEFPNIFPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8G2</accession>
    <name>A8Q8G2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3265</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729721.1">
        <property type="nucleotide sequence ID" value="XM_001729669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8G2"/>
    <dbReference type="FunCoup" id="A8Q8G2">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q8G2"/>
    <dbReference type="GeneID" id="5854027"/>
    <dbReference type="KEGG" id="mgl:MGL_3265"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3265"/>
    <dbReference type="InParanoid" id="A8Q8G2"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="121"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP42507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="269" mass="29141" checksum="011D07CC2AC26BF5" modified="2008-01-15" version="1">MSSQSPAGSNWESLRKKLHGSPTSSVVRKKRSAQQMHTLSATTKQLRHSKSVELPSKNPLWFADDLTPEDLALAKSIQASKSSDSTASETHEISQAQTQTKRRLVLGEPVNPSPAKQTIGNYVAIDCEMVGVGPRGTGSALARVSIVNWHGHVVLDTFVKPKERVTDYRTWVSGVRPGDLKKAPSFATVQARVADIIKGRVLVGHAIQNDLRALLLSHPRPKIRDTAGFKPLQELSGNKSPGLRTLSKLLCRGCTSDDGCVPHAETCMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8K5</accession>
    <name>A8Q8K5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">INO80 complex subunit F domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729743.1">
        <property type="nucleotide sequence ID" value="XM_001729691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8K5"/>
    <dbReference type="STRING" id="425265.A8Q8K5"/>
    <dbReference type="GeneID" id="5854049"/>
    <dbReference type="KEGG" id="mgl:MGL_3287"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3287"/>
    <dbReference type="InParanoid" id="A8Q8K5"/>
    <dbReference type="OMA" id="QSDAIKY"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="5">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="138" mass="15103" checksum="92620BADBE86662D" modified="2008-01-15" version="1">MASGAASSGGTAPSKQKSKAYLSSVAIQSDAIKYRQKYKELKRKVHEIEQENDKLQALTLRIKGNIQRLRLERAILYERLEADVRNVPVASSPTGAQNQVSSSPSSSNQVNASKEQDAESTHKEVDDMGVSVDIEDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q902</accession>
    <name>A8Q902_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 9">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 9"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729346.1">
        <property type="nucleotide sequence ID" value="XM_001729294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q902"/>
    <dbReference type="STRING" id="425265.A8Q902"/>
    <dbReference type="ESTHER" id="malgo-a8q902">
        <property type="family name" value="A85-EsteraseD-FGH"/>
    </dbReference>
    <dbReference type="GeneID" id="5853653"/>
    <dbReference type="KEGG" id="mgl:MGL_3381"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3381"/>
    <dbReference type="InParanoid" id="A8Q902"/>
    <dbReference type="OMA" id="PSDCPWG"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120516">
        <property type="term" value="F:diacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="276" mass="30348" checksum="BD98EF8B1DB195C5" modified="2008-01-15" version="1">MSLTIQSQNKVFEGVLTKYSFRSKVLGGLEAKMNVFLPESANAGHKVPVLYFLSGLTCTEDNAAQKGHFFEAAAKEQLAIVFPDTSPRGANIPGEEDSWDFGTGAGFYVNATKEPWNKYYNMYDHVLKEIPQLIASEQIPIDVSRASIFGHSMGGHGALVMYLREQAHFRSVSAFAPICHPTNCETGKKLFEGYLAGGIDDGKQYDAAVLLSKLESSRQVDVLVDCGLNDNFYKQKQLQPESLVEAGKKSGIDTARIQVRLHDGYDHSCTSIANKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q947</accession>
    <name>A8Q947_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729375.1">
        <property type="nucleotide sequence ID" value="XM_001729323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q947"/>
    <dbReference type="STRING" id="425265.A8Q947"/>
    <dbReference type="GeneID" id="5853682"/>
    <dbReference type="KEGG" id="mgl:MGL_3410"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3410"/>
    <dbReference type="InParanoid" id="A8Q947"/>
    <dbReference type="OMA" id="NKLECFC"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005413">
        <property type="entry name" value="COX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="203" mass="22813" checksum="8FC21CCE183AC117" modified="2008-01-15" version="1">MYAAAGLVAALGLTYAAVPLYRAFCAATGYSGTPMTDSSRYSEPSRLVPSYTDPYNAAHATERIRVSFNASTSNQIPWSFVPEQREIFVLPGETALTFFKAHNKSDQDIIGIATYNVIPDRIAPYFNKIECFCFEEQKIRAGEEIDLPVFFFLDKEMLEDKESRDVKDIILAYTFFSARRNPVNGQLEPDTDLSRYTVGKDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9I8</accession>
    <name>A8Q9I8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729454.1">
        <property type="nucleotide sequence ID" value="XM_001729402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9I8"/>
    <dbReference type="STRING" id="425265.A8Q9I8"/>
    <dbReference type="GeneID" id="5853761"/>
    <dbReference type="KEGG" id="mgl:MGL_3489"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3489"/>
    <dbReference type="InParanoid" id="A8Q9I8"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728140" evidence="1">
        <location>
            <begin position="19"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="328" mass="37260" checksum="8B5C66021B5165F3" modified="2008-01-15" version="1">MRLGVFYLIYAALFRCSSEPFSFNYNPNHELLVCREMASVHENVAPVIHDLGVKTHDLLHPYAGKYMDATHDAWRRYSPALYKSSKQMHDTYRMHVVPGARALYKQAHAWSLPHQRTLHSYYKKHVYPYVKKMNKALNPYMRTYHKDVHPHVLKAGRSLFDAHDASSKYYVEKLHPRIKNNIYNAYKFGRHTAFPFAHHHYVTHAHPHVKKLHASVSAAVDQVLQKYGIKDGSLVNKVTDKVQDVYSEAGAKVSEAASAVDETLSKSGLKDGSVVNKVPEAAQNAYEQASEVIDQTLKDHGIKEKTMGESVADAVQDAYEQVEEAVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA58</accession>
    <name>A8QA58_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">MGL_3617</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729150.1">
        <property type="nucleotide sequence ID" value="XM_001729098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA58"/>
    <dbReference type="FunCoup" id="A8QA58">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA58"/>
    <dbReference type="GeneID" id="5853456"/>
    <dbReference type="KEGG" id="mgl:MGL_3617"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3617"/>
    <dbReference type="InParanoid" id="A8QA58"/>
    <dbReference type="OMA" id="WTIIEYV"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EDP41936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="371" mass="43292" checksum="49016390D657CC16" modified="2008-01-15" version="1">MVDALTTYTRAEVAQHNKKEDCWVIFDKKVYNITEFIEDHPGGEDVVLEYAGKDVTAIMKDSLSHVHSRSAYLMLIDFHIGSLAQSEIDEEDQSQDGLPPPFLPADAHIADDFHPQETDMAKDFKHNKFLDLKKPLIPQMWTSSFTKEFYLEQVHIPRHCREPAKLMPYDFLEVFTKTPWYVIPILWLPIAAAFFHVSATQFKSQFTANGSTVLASTEGYSAAFGCFVFGVVFWTFLEYLFHRFIFHMDRVLPRHQFFYLLHFLLHGIHHFLPMDRYRLVMPPILFAILSFPMLLLAHAVFPPAIANGVISGSYSMYVVYDTMHYALHHSKLPEYVREQKRYHLEHHYKNYELGFGVTSKIWDYVFHTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAE8</accession>
    <name>A8QAE8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729240.1">
        <property type="nucleotide sequence ID" value="XM_001729188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAE8"/>
    <dbReference type="FunCoup" id="A8QAE8">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAE8"/>
    <dbReference type="GeneID" id="5853546"/>
    <dbReference type="KEGG" id="mgl:MGL_3707"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3707"/>
    <dbReference type="InParanoid" id="A8QAE8"/>
    <dbReference type="OMA" id="AMYLVRQ"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="122"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="268"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="719" mass="77069" checksum="850C0557E2793254" modified="2008-01-15" version="1">MGASTLNLTPAERQSFAQLYAKADPTNTGVVSGDAAVKFFEGFKLPTLTLGQIWSVADDGNNGFLTPNAFGVALRLIARAQRGESVNEQAVHTPGAPPVYQSSAGVPLSTDLASSSILTSEDKARFTRIFAMVGPKNGVLSGEQAKDVFLKSKLPYAKLGAIWNLADTKQRGALDLTDFIIGMHFIQGTMNGTIASLPATLPPGLYEAASEPSTIPTTPIQPQHTGADSYMGGAPVLDTATPARSTTQPSPVLRQAPSTEGWDILPADKARYDGFFDSLDADRMGFVEGNVVVPFFLQSGLDESTLAHVWDLADLTQSGSLSRDEFAVAMHLINDRIAGKELPQQLPASLMPPSMRSQALPQAVDVNQTETQRELFSLLDSDEPPTMSKSEAASAFGTVPNTVLPSTSMPAPEPPATRSHAASALDAVEAASSPTSNAKPHATSSKNIPSLFDDDFSAPPPAMPTPVRDARHEQTEEALTSSNKALDDVKTRHAAAKSTLASQATTLAELEGQLEQAKIAFAKEETALAEVESKVQAQDAEIVKLRQDVIRQESELSAIRTQRDELEQRLLQDRESAHSLKRQLTELQEQTMQLREERDRLEQESLKEAGMAATTNKQLAAAREERDALSRQSMPKASTPSSSGRRMNPFEALFSTSPKTEEPDRFESLYGFDSFTAAGAGVAAATAGQNGLRSPAPNAAQLMPRPMPPMAHQSVVNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAF5</accession>
    <name>A8QAF5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729247.1">
        <property type="nucleotide sequence ID" value="XM_001729195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAF5"/>
    <dbReference type="STRING" id="425265.A8QAF5"/>
    <dbReference type="GeneID" id="5853553"/>
    <dbReference type="KEGG" id="mgl:MGL_3714"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3714"/>
    <dbReference type="InParanoid" id="A8QAF5"/>
    <dbReference type="OMA" id="YANERAS"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="182"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="428" mass="48148" checksum="1DEEB9E89EC66534" modified="2008-01-15" version="1">MDMWWLGGSLVRAAPHMQTAWRCAKSHRAYVTGPRNAWDELLADVSPQPNGAVHAAMQKPTWASESVPRDVLYANERASTPKTLQQRRRTYDTSALTPSESAQFRRIFELLEQEMDVPRMQASSSELGAFAERNAIRSRKLTARGGGVGTRFEASLEGLAAQISPEELDRGVDRLWQDIHSHGSAVDAWRWAEAHVWTSDTSAPTTASTSPNIELAQYGPQTPFFAPALHMLLLAFRDKFHVPHTALAVLERTRQLGPHAYVLGCTSSLFAEIIRTQWLCLRDAQAVLATAYEARAVGILSHADGHASSRDDAALRTQIERIRSELRARVMRAAQNRTFVEKENESNETFLRMQVDDHDILQMVTELGRLVGGRTIRSAERTPNPRPRLTTSARQKKPPKKNLMIYPQNPHALLRTELQRTKTREPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAF9</accession>
    <name>A8QAF9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729251.1">
        <property type="nucleotide sequence ID" value="XM_001729199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAF9"/>
    <dbReference type="FunCoup" id="A8QAF9">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAF9"/>
    <dbReference type="GeneID" id="5853557"/>
    <dbReference type="KEGG" id="mgl:MGL_3718"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3718"/>
    <dbReference type="InParanoid" id="A8QAF9"/>
    <dbReference type="OMA" id="HERAITC"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="272" mass="30406" checksum="F02C0FC067AA2443" modified="2008-01-15" version="1">MRLWDVRTGECLFVWEFPTAAKCVSFNKHGTQILVVTEERMGYRGALRVFNINRDPSSWKKQETEPMRTITFSGSKATVASFDVFDKHILTGHENGKVALYAHDTEEGESGIDAELEIHQVKAHAENVTDLQLGWDGTYIVTSSKDKTAHIIDASTLDVIKTYATDTPLNSAISLPTRPYVVMGGGQEAMSVTTTSARQGKFESRFWHKIFEEECARLPGHFGPINTLAVHPTGNAYASGGEDGYVRINWFDESFFKSRPYGPDFEIANEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAK3</accession>
    <name>A8QAK3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729295.1">
        <property type="nucleotide sequence ID" value="XM_001729243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAK3"/>
    <dbReference type="FunCoup" id="A8QAK3">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAK3"/>
    <dbReference type="GeneID" id="5853601"/>
    <dbReference type="KEGG" id="mgl:MGL_3762"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3762"/>
    <dbReference type="InParanoid" id="A8QAK3"/>
    <dbReference type="OMA" id="VSKMMQG"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="99"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="499"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="8">
        <location>
            <begin position="671"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="313"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="86613" checksum="150FF8E2D25A9797" modified="2008-01-15" version="1">MRIAAPATVSGRRVNQTGLLSRTLLSPRHLHTTACRLLPPGGGFPGMRMNMQGQEAQPGETLAQYSQDLTKLAREGNVDPVIGRDSEIRRTIQVLSRRTKCNPVLVGPAGVGKTAIMEGLAQRIVNKEVPESLQDKRVCALDLGALLAGASYRGAFEERFKALLHDIEAEQGKIIVFIDELHMLLNLGKAEGSVDAANMMKPMLARGTLQCAGATTYDEYRKYIEKDPALARRFQSVSVLEPSPESTVAILRGLRTRYEVHHGVGVSDGALVTAAAYASRYLTERKLPDSAIDLLDEAMSALRLQQESKPEVIETLDRDILTLQIELESLRHENDPLSVERKKVVEKELQEKRQESAALTSSWMEERSKLDRVKEIKEQLEQSRIELERATREGNFQRVAELQYGRIPELRRELPSEEENNDASNKNMLHERVTSDDIAAVVAKMTGVPVRNLLRGERERLLGIEDSLRERIIGQDEALASIGEAVRLSRAGLHSSKRPLASFMFLGGTGVGKTEAAKGLAQFLFDSEKLVQINCSELSEPHSVSKLVGAPPGYVGHEDGGQLTEKVRRQPYSVVLFDEIEKANRSIHTLLLQVLDEGRLQDSQGRQVDFRQTIIILTSNVGADVLYQPGATDATGHVTEESREKVMADVQRAFPPELLNRLDEQIVFNNLAPETLHGIVNIRLKEIDARLHDKRVTLRVDEAARNWLAKKGYDPAYGARPLNRLIQKRLLNPLASNIIQGKVLEGDTVEVHVDESANALTLDVLTGPHHEADANPDAASAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAX1</accession>
    <name>A8QAX1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729058.1">
        <property type="nucleotide sequence ID" value="XM_001729006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAX1"/>
    <dbReference type="STRING" id="425265.A8QAX1"/>
    <dbReference type="MEROPS" id="C85.003"/>
    <dbReference type="GeneID" id="5853365"/>
    <dbReference type="KEGG" id="mgl:MGL_3846"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3846"/>
    <dbReference type="InParanoid" id="A8QAX1"/>
    <dbReference type="OMA" id="HLAYHSW"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="45"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="348" mass="39711" checksum="D7C9AD78EDC06B71" modified="2008-01-15" version="1">MARTQRKSTTTPPNASRVSRRRAHAAPDPEQDDQDLNTQLHKMGLYAADTRGDGNCLFRYVDFACAHMHANESALSDQLYGDPKYHAQIRQETCDQLEQHPDLYAGFVETGSTYEQYVRQMRLPGTYGGHLELSAFAHLKQKRIRIVQPGFVYVVACDDDSYSARSSRARRERHRRHVLTSDTIDTPSAKKKSHIAEPECVGPLHLAYHSWEHYSSLRSLQGPHKGHPCIPDSMSESHERDAFKPDAEAERLVCLSVPGHSRRTVRRLLQEHNGAWEDVVEELIRRDADGESDTSAHSESQTSSDDENERRRKRPLRTQDRRHQTNGKDTQTNSSSPRHTTGIRELMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBE3</accession>
    <name>A8QBE3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_3904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728910.1">
        <property type="nucleotide sequence ID" value="XM_001728858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBE3"/>
    <dbReference type="FunCoup" id="A8QBE3">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBE3"/>
    <dbReference type="GeneID" id="5853216"/>
    <dbReference type="KEGG" id="mgl:MGL_3904"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3904"/>
    <dbReference type="InParanoid" id="A8QBE3"/>
    <dbReference type="OMA" id="NEWIAKW"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="77" mass="9197" checksum="3B58472DE15D2DD8" modified="2008-01-15" version="1">MPQQLDLKTAVFDSRFPNQNQTRHCYVDYYRCVNTKGEDFEPCKQFFSTFHSLCPNEWLEKWDEQRENGAFPAKLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBU4</accession>
    <name>A8QBU4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease</fullName>
            <ecNumber evidence="7">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728948.1">
        <property type="nucleotide sequence ID" value="XM_001728896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBU4"/>
    <dbReference type="STRING" id="425265.A8QBU4"/>
    <dbReference type="GeneID" id="5853254"/>
    <dbReference type="KEGG" id="mgl:MGL_3942"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3942"/>
    <dbReference type="InParanoid" id="A8QBU4"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="8">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="86" mass="9222" checksum="2F3DE0FF54F2942E" modified="2008-01-15" version="1">MLVSDAVPSVQATAMTQSYTWRSGIPDACVSGTGKHRVECALGVDEAGRGPVLGPLVYGIAYCPMDMQEHLRSMGFAGVINYLRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC21</accession>
    <name>A8QC21_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_3965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728971.1">
        <property type="nucleotide sequence ID" value="XM_001728919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC21"/>
    <dbReference type="FunCoup" id="A8QC21">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QC21"/>
    <dbReference type="GeneID" id="5853277"/>
    <dbReference type="KEGG" id="mgl:MGL_3965"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3965"/>
    <dbReference type="InParanoid" id="A8QC21"/>
    <dbReference type="OMA" id="RHERFDM"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP41757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="406" mass="45637" checksum="E3692D33CAA3E9F7" modified="2008-01-15" version="1">MERVWQPLQHALQRIVSLQQDDSPALWTGRIFNVDLAFRPRQFYVQGVLLGVLMVFLLGSLLGRVYNRWVVKSWHLVYARALETEFSQVGIDTSGIAPKLIWNGADEACLFATGRRGVDSLHAVLTLRPWHDPFMIIFSIIYDIFALPASPWFKKEQVTLTFTLPRSPRVNGGTFAIIDKTELHQARHERFDMKFARVSDGANASQARDLDERFAIASEAGNITDRWLGEIGSRGDKQRARLGITEALNSSAGQFLVSLLFTDQPRVEPATGPVPEAQRIERLELTLRLPRTEAEAKSSLPLLTLALDIADALSMTASGRSDILALHPDTYAALKKTRTEVAAQLEEISSRDAKAQEAEEAEEERRRLQQEKFDKLSPAEQAKVRFISFFFLFTPAYGNSQATHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC34</accession>
    <name>A8QC34_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">MGL_3970</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728976.1">
        <property type="nucleotide sequence ID" value="XM_001728924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC34"/>
    <dbReference type="STRING" id="425265.A8QC34"/>
    <dbReference type="GeneID" id="5853282"/>
    <dbReference type="KEGG" id="mgl:MGL_3970"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3970"/>
    <dbReference type="InParanoid" id="A8QC34"/>
    <dbReference type="OMA" id="QYMTAFP"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725561" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="22"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="162"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EDP41762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="457" mass="51707" checksum="AC0640B33793D791" modified="2008-01-15" version="1">MRMWPAALGWIFLISFTCIHAHIGRGLSLGNTSLSVISQNKRAHFANESQLANVTSFKKQCRVEDLPVSGKLRKAYPKDNKIASIQDHDEDAKELWAKIKSSNTIPSNVEQKQGVKHHMAISKHESHQYSDSADPDCWWSATMCTKPKINVTEDITFCPEPETWGLTFDDGPDCGHNEFYDFLQSKNLRATMFYIGSNVLNYPLQAQRAITDGHEVCVHTWSHHYMTTLDDEQVFAELYYTIRILKDVLGVTVRCWRPPFGDVDDRVRAIADQLGLRTIIWSRDTDDWNVEPDGDASKEKINSNYESIINKDANSNSSSSGNIVLTHELSRATMHEFMRMYPKIESAFEHIVPVHVCMNNSHPYVENAPTYPSFQEFVSGDIIARNIPNMDNYSIQVASKLSITPLEEQNHTNNSSDSAQHTSDPSSDPSSSTHVTAFSPHLSITLTFLTIMAIWHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCD3</accession>
    <name>A8QCD3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728829.1">
        <property type="nucleotide sequence ID" value="XM_001728777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCD3"/>
    <dbReference type="STRING" id="425265.A8QCD3"/>
    <dbReference type="GeneID" id="5853135"/>
    <dbReference type="KEGG" id="mgl:MGL_3996"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3996"/>
    <dbReference type="InParanoid" id="A8QCD3"/>
    <dbReference type="OMA" id="QIELAMF"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="69204" checksum="9965E55A025045A0" modified="2008-01-15" version="1">MAASAFISGADVLYLAAGLAGLLVAVPLLFILNQLVQALYRMTIGELINPWKHIPKVKTTDPLSLIFGDFRAIKAADPAQQHVIWMNKLGQVYRYRHMFYVQRVLLADPKALIHVLSPAKAYQYPKPEYTSSFLAAVLGDGLVSIEGEKHARQRKIIAPAFAPSVVKDYQPTIHRHAKLLVEKLRLIVQQEIDRHSGKIPADTHITGQSESDRSVVLKNPGSEAVIDVLFWLSRTTLDIIGEIGFDADFRSLERGNRDPLANSMATLMEAVLNIDLGLAIFLILSEKPGLQWLRKIPTKRTTTIRDAKKTVEKHAEEIVERMRNEILSESQGLSKENFDDGSATRSKSLISRMIRANMASDLKPSERMSNAELMGQMTTLIIAGHETTATQNSWALWLLAMHPEAQDRLRKELQEAVAKERAEMDNLSEEERAIYDTQPVRDINSLPYLDNVVKESVRMLPSIPSTVRVALKDDVVPLSRGYKRADGKGTYNSIMIPKGHELFIPLNVIQLSKELWGEDAQDFNPSRWDNLPSSVINAKMPPGHLFAFLSGPRSCVGKQTAILETQVILAHMILNFRFDVVPGWDLVQRQQIVRRAFVEGQWKEGIRMPLIMTPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCP8</accession>
    <name>A8QCP8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728866.1">
        <property type="nucleotide sequence ID" value="XM_001728814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCP8"/>
    <dbReference type="FunCoup" id="A8QCP8">
        <property type="interactions" value="637"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QCP8"/>
    <dbReference type="GeneID" id="5853172"/>
    <dbReference type="KEGG" id="mgl:MGL_4033"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4033"/>
    <dbReference type="InParanoid" id="A8QCP8"/>
    <dbReference type="OMA" id="EEGPYWP"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="206" mass="22312" checksum="2630E7A588D0FEF8" modified="2008-01-15" version="1">MSTNAVPEILWAQRSSASVPEKNVIMLTINVPNMTAEATKCDLTNTGLHFESTVQGDASKGIEGNKFTFDVEFYENIVPSESKQHLTSKYLYLVLRKEKAQDEYWPRLTKDKVRLHNVKTDFDKWVDEDEQDGEMNAGDDAGFDPSMLAGGGAGGMDLNSIMSSLGGAGGSPDFGAMGGDMDAGDDDDDEDDKGSEGKNPKVEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCT5</accession>
    <name>A8QCT5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_4045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728878.1">
        <property type="nucleotide sequence ID" value="XM_001728826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCT5"/>
    <dbReference type="STRING" id="425265.A8QCT5"/>
    <dbReference type="GeneID" id="5853184"/>
    <dbReference type="KEGG" id="mgl:MGL_4045"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4045"/>
    <dbReference type="InParanoid" id="A8QCT5"/>
    <dbReference type="OMA" id="FASWVTH"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="578"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="627"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="713"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="534"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP41664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="806" mass="92442" checksum="2877C78595BA41CA" modified="2008-01-15" version="1">MQQGQVLYAPSPLRDTYERIKVYWMRQPRIIFAIYMIMVLVIARGTVFVLYHIIETDGKGLMQGYTKSKYEAPVVNDTVPIDSTSAAALTTSAFPAQLDSKLYWPSLDMIYTRYDPHRGEIPLDIMALLNSPPNLTAPHAFTNATTVPEEAWKHHPWTRAVNGSKTSMEDAMRPNLQPREHDWRPPPHNEWKSPLQDTGILHPNPSEHIQFKFEDPSRFSGKKHDTARDRVLERRRKLVKNAFIRAWQGYKNYAWGADEVSPVSEKPNNNFNGWGATIIDALDTLLVMGLHDEYLLAREHVYDVDFHYVGGQRSAYASADGRIPVFETAIRYLGGLLSAYDLSGDELMRDRAEELAQIILPAFDTLSGLPVGRMRVDDKTEYTPSKPRGYHESMVLAEATSMLMEYTRLWQVTGNRTYFDRVQRVTDFLDSNMTKMSLIGTLLPQSLYPEESILSGKYSFGGGIDSYYEYLVKEHQLLGGVVDQYSRMFTEAMDSAEKHLWKNVTVVPNAPSLVVVADTYARGRSWARLEHLACFSGGMMALGSRVVPNRRHYLNIARLTTESCYWSYNSSLTGLGPENMEFFRPFDKDRYHITSAADGTRHRDSPVGDPFVGVRRIVSEDYRNRPEVIESVLYMWRTTGDPVWQERGWQMFASWMTHCLVRSGVSTIRDVNQVPVLYDDSMESFVFAETFKYYYLLFSPPDLVSLDDFVFTTEAHPFLAPKKGRWARPGDVPVSFPKFHRAFPTFDRPSGTLTSMQKNQLISQWEHVNVLHRVSLDKWPEDDPAAQKLFLEAFWARVNAAQQQRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-01-24" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCV4</accession>
    <name>LIP7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted triacylglycerol lipase LIP7</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
            <ecNumber evidence="4">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LIP7</name>
        <name type="ORF">MGL_4051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Microbiology" volume="162" first="1069" last="1079">
            <title>Secreted lipases from Malassezia globosa: recombinant expression and determination of their substrate specificities.</title>
            <authorList>
                <person name="Sommer B."/>
                <person name="Overy D.P."/>
                <person name="Haltli B."/>
                <person name="Kerr R.G."/>
            </authorList>
            <dbReference type="PubMed" id="27130210"/>
            <dbReference type="DOI" id="10.1099/mic.0.000299"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">Secreted lipase involved in Dandruff and seborrheic dermatitis (D/SD) probably via lipase-mediated breakdown of sebaceous lipids and release of irritating free fatty acids (PubMed:18000048). Has triacylglycerol lipase activity and is able to hydrolyze triolein (PubMed:27130210). Mostly converts monoolein to di- and triolein, while free fatty acids are only produced in low amounts (PubMed:27130210).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EC" id="3.1.1.3" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728884.1">
        <property type="nucleotide sequence ID" value="XM_001728832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCV4"/>
    <dbReference type="SMR" id="A8QCV4"/>
    <dbReference type="ESTHER" id="malgo-a8qcv4">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="GeneID" id="5853190"/>
    <dbReference type="KEGG" id="mgl:MGL_4051"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4051"/>
    <dbReference type="InParanoid" id="A8QCV4"/>
    <dbReference type="OMA" id="VMGQHGV"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728162" description="Secreted triacylglycerol lipase LIP7">
        <location>
            <begin position="22"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="125"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="W3VKA4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18000048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="27130210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="468" mass="51330" checksum="9D183016E2B303A1" modified="2008-01-15" version="1" precursor="true">MFPRQILVFAALGLCFALVAGATQVSGVRRWELRRRFSFEDSFYHPPSGWESASPGEVLASRKVDVSPASIFNLGINAYQLLYRTTGLTDGEATTSVTTVLVPYNYDKDKVMVSALYEDSFSSECAPSKQLKSGHFISQNVAVAYQSLFLTTLLHEGWVVTVPDHEGPQNAFGAGPLEGHAILDAVRATINYDRIGLGSNAKVTGYGYSGGAMALGWAASLHKSYASELNVVGWAMGGTVTRMADWLRYIDGTGGAGFAVAALGGISSVDNDLQWVQDNLTPLGKIVLEKSKHSCMYKNLLEEAYKRFISDTYFQGGSTFFENSGAMYALNKYNLGEDGSKVPSAPVFMFHARNDIVVPYAMAQATARSWCQQGAQIRFTTYAGVEMGHTSAGIASLPDVLHFLRDRFNGKQWGETCQYPVVLDPWFNLFNLGESYAEFVQQLLDLLGRRIGKDDHILMAKLKKQEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD58</accession>
    <name>A8QD58_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_4126</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728791.1">
        <property type="nucleotide sequence ID" value="XM_001728739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD58"/>
    <dbReference type="GeneID" id="5853097"/>
    <dbReference type="KEGG" id="mgl:MGL_4126"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4126"/>
    <dbReference type="InParanoid" id="A8QD58"/>
    <dbReference type="OMA" id="WIYWARA"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF3">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="425"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="598"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP41577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="688" mass="75259" checksum="189AA26186F896CF" modified="2008-01-15" version="1">MSLHGPAEVPKRSDSATTHRQRRTPSLRVQTTQLRSFSYDSEPGARRGQVPVSSSAAAAAAAAAGQSATGRSRRSTMTSHGQLPSAGGAGTVGGSTSRTQSPLSVLSPRTPSSHAHTRLFGRAAAYAAQSLVDVVTRSLSPSSTHGYASILFDMPTASSPISSIADWDHRHADAGTSSNDHRTAAHSTTSSANGPNGGSDIRHPVQQHQHHAHHHVNDDDRRSSSDTTAGSAPAYALAGDDDEVQLLRTHARKSTHSEHSIPMDDIVAPKARHGAVWLHPKPSKASAASTHRRQRNRQAEHAARWTAEHAWARLRTGLSLLANPRELAASVHQHVHAQWIYWARAFRDPMTDQRIWWPPWLASYVPLLIWVGISVMSTTMVMLFHVQLFHALDVLSTTLRSLGLVGRVLFGMIIFVLTFPPMPLYSTMIVLSGFAFGMWQGFLVSYVAALTGAASVFVLSRTHLRAWMMRLLAHAGGLQRVIRAIELRPQLLFLVRLAPYPYNLLNMLLASSHVLTFRTYITCTALALPKLLVHTSIGASIESFASYHSAANETQGADPSHKKTNTVRQVFGGFGIALCVGIFLYLYYVTRRAVDTLDSDEGEDAESLDESATTDMEDDKDPLASGVYDQSKPGTPLRRVTPLELRRPRSVIAWDHLDRLPPPPPEPPLSWLAESIEQFERAAEQRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD78</accession>
    <name>A8QD78_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_4146</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728667.1">
        <property type="nucleotide sequence ID" value="XM_001728615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD78"/>
    <dbReference type="FunCoup" id="A8QD78">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QD78"/>
    <dbReference type="GeneID" id="5852983"/>
    <dbReference type="KEGG" id="mgl:MGL_4146"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4146"/>
    <dbReference type="InParanoid" id="A8QD78"/>
    <dbReference type="OMA" id="IMGPCSI"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="38"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="363" mass="39738" checksum="A42E30F326356AF0" modified="2008-01-15" version="1">MNTRVVGLESLVSPSILKDELPASERSKATVDLGRKNAAAIINGKDDRLLVIAGPCSIHDSEQASHYAQRLYDEYKRRWKDGLVIVMRAYFEKPRTTVGWKGLINDPHINGTCKINEGLRVARQVLLDVTEIGLPVACEVLDNFTPHYLSDLYSWGAIGARTTESQLHRQIVSGLSMPIGFKNSTDGGVGVSLDAIRASSQPHTFISLTDQGMSAIVSTTGNHDLHIIHRGGKSGTNYDEHSVAASKVELSNTLPNKCPSIMIDVSHGNSNKDHRNQMKVANDVADQIERGQDAIIGVMIESNIKEGKQSEPKNGRTSDDLEYGVSITDGCVSLETTTEILDRLYAAVLARRLKLRQPRTAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDD5</accession>
    <name>A8QDD5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal calcium binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728710.1">
        <property type="nucleotide sequence ID" value="XM_001728658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDD5"/>
    <dbReference type="GeneID" id="5853016"/>
    <dbReference type="KEGG" id="mgl:MGL_4189"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4189"/>
    <dbReference type="InParanoid" id="A8QDD5"/>
    <dbReference type="OMA" id="GNCAKSI"/>
    <dbReference type="OrthoDB" id="3344425at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725580" description="Fungal calcium binding protein domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9210" checksum="BBFF5B23819F9915" modified="2008-01-15" version="1">MYKALVLAAAFASVAFAKVSVKGYEANIKAGDLSCKFGSGDILSACGNCAKSITECATSNPNKTKEVCISDISSFAKDCGGCAVDILECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDF4</accession>
    <name>A8QDF4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_4199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728720.1">
        <property type="nucleotide sequence ID" value="XM_001728668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDF4"/>
    <dbReference type="GeneID" id="5853005"/>
    <dbReference type="KEGG" id="mgl:MGL_4199"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4199"/>
    <dbReference type="InParanoid" id="A8QDF4"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="59"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP41506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="225" mass="25145" checksum="A3A30856D0F73157" modified="2008-01-15" version="1">MGDGKKNRRTDVKPFDDTKLVPVEKIESNQPDMRVTLEVKMKEGRKHGKPMGLINGTTYVAPKTPTMLTVTAKNTTNPMDAGTYGRNVNAVTAPYNSMVEMTILNLSDDVHPFHMHGTKFQVVHRAYGSDGKKPQVPEVDKLENPVRRDTVAVDGFGSVTIRFLASNPGAWFMHCHMDWHLSAGLAMVMVQAPEKAKEVLKVPSYVEEQCKVWQMQSDHKTLRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDQ6</accession>
    <name>A8QDQ6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000023">
        <property type="protein sequence ID" value="EDP41415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728629.1">
        <property type="nucleotide sequence ID" value="XM_001728577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDQ6"/>
    <dbReference type="STRING" id="425265.A8QDQ6"/>
    <dbReference type="GeneID" id="5852942"/>
    <dbReference type="KEGG" id="mgl:MGL_4228"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4228"/>
    <dbReference type="InParanoid" id="A8QDQ6"/>
    <dbReference type="OMA" id="PPKIGTG"/>
    <dbReference type="OrthoDB" id="2555325at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="366" mass="37597" checksum="6515281573D9D8E3" modified="2008-01-15" version="1">MTTFKVRLRVPPSTSSASGAGGASRQASTDSASASTKEATASPRSSEPGHDADMSVRSEMTYSSEDELADESMALDTTADTTTESPHTTKVKKATKQRRTAPPPGSISAVAATLTLEELDALPSAKRRKGLKTRGAPGPGRGWRKGLSKGQKPVYRLPDSGMSTADLPQNLAVHPSTPATFTKSASASGAGGGRSGATSTTNASSSSSSATAVPSKRSRQGTTNASNTTSPATSSSLASSSIKVAQNSPDAVFRYPAIPTSKDLPDILPLARIPNFIPAIVPLERSSGTKKPRAWHPGTREILSIGGRTWRTPVWLSEKQKGLSSSTPDQDTDSITDSPAPDPIAPSTSITASASPEGAATPSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8QEG7</accession>
    <name>A8QEG7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_4268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000034">
        <property type="protein sequence ID" value="EDP41379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728593.1">
        <property type="nucleotide sequence ID" value="XM_001728541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QEG7"/>
    <dbReference type="GeneID" id="5852901"/>
    <dbReference type="KEGG" id="mgl:MGL_4268"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4268"/>
    <dbReference type="InParanoid" id="A8QEG7"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002725277" evidence="1">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="82" mass="8935" checksum="093E8CCBCA75A075" modified="2008-01-15" version="1">MSTPRTLAFLAAALWCAFAIVSAEFTLELKRDAGSSAPNPTNDKALLDGIVAKYLRNAESYYKNTGKHARFVNSTKLKKRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRG6</accession>
    <name>A8PRG6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732273.1">
        <property type="nucleotide sequence ID" value="XM_001732221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRG6"/>
    <dbReference type="STRING" id="425265.A8PRG6"/>
    <dbReference type="GeneID" id="5856579"/>
    <dbReference type="KEGG" id="mgl:MGL_0048"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0048"/>
    <dbReference type="InParanoid" id="A8PRG6"/>
    <dbReference type="OMA" id="ALMTHKG"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP45059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="41220" checksum="D39AA914BF7C7BC2" modified="2008-01-15" version="1">MHRTLTFVSDARENGGAAKHACAFALSGKPRSHVRLKKSGKLQHDETLTGIIVHCCSDTTMALRNYVQRRNHKERSQPQHRKHLGLLEKHKDYVERARAHHIKRDKLQRLRQKAADRNQDEFYTGMIGKKTERGVHIDSRGNRPLENDVVSLLKTQDAGYLRKQLASERKKYKALVEELAPRVPGMRLALLQKKPDLADALQRAKLLGEKRASSKKQGRVQGAGKKTKWVDSTEELRQAEQTAKETSAAAATGTTKLTRADKVGERQLRIKIRELDARQRRLDALSEAAQKLDVVRTLMRTRGAHAVPRKQQMQDIKDAIGKRGAQLTAKGLVVEDDDDDEDTDMHARSKTKYYKWSNERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRS5</accession>
    <name>A8PRS5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732342.1">
        <property type="nucleotide sequence ID" value="XM_001732290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRS5"/>
    <dbReference type="FunCoup" id="A8PRS5">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRS5"/>
    <dbReference type="GeneID" id="5856648"/>
    <dbReference type="KEGG" id="mgl:MGL_0117"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0117"/>
    <dbReference type="InParanoid" id="A8PRS5"/>
    <dbReference type="OMA" id="SVYTAFQ"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF21">
        <property type="entry name" value="DNAJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="208" mass="22798" checksum="BBB8834F75B54D67" modified="2008-01-15" version="1">MGISSEGFGIKRSDILTPMNHGIPDYYAILHVDAKATQEDIKKAYQRESLKCHPDRFPHASDEEKRHYTQTFQSVADAYYILSDTKRRAEYDATRLSSSSSAHADFSFEHTPQPNAQTQFANVWADLLRPEIERQLPVWRTTGTVSGAALGYIIGNIPGAIGGAVVGHSLGAVRDAKGRAVSEVFLSLPLSARANVLRALASKVLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRU1</accession>
    <name>A8PRU1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit J, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_0128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732353.1">
        <property type="nucleotide sequence ID" value="XM_001732301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRU1"/>
    <dbReference type="FunCoup" id="A8PRU1">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRU1"/>
    <dbReference type="GeneID" id="5856659"/>
    <dbReference type="KEGG" id="mgl:MGL_0128"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0128"/>
    <dbReference type="InParanoid" id="A8PRU1"/>
    <dbReference type="OMA" id="KPMWPFY"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP45139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7340" checksum="2838534465484D5D" modified="2008-01-15" version="1">MAFFGFRAYPTPILKPLWPFFASSAIVYYCVSKMQYAGVRSSEYAKDPKNPYLKQIAQESKLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRZ9</accession>
    <name>A8PRZ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0164</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732389.1">
        <property type="nucleotide sequence ID" value="XM_001732337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRZ9"/>
    <dbReference type="STRING" id="425265.A8PRZ9"/>
    <dbReference type="GeneID" id="5856695"/>
    <dbReference type="KEGG" id="mgl:MGL_0164"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0164"/>
    <dbReference type="InParanoid" id="A8PRZ9"/>
    <dbReference type="OMA" id="HEWEPEP"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="484"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="404"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="612"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP45175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="652" mass="69776" checksum="033056934878D9C0" modified="2008-01-15" version="1">MAKTYQQSHATSKPHDGLPVWPSSVVVQESQSPLELHAIPRETLTAVNNDDALSRPSFPSSSDDEYIQSIMAPTITDIESDSHLHDASHNPGMGLLLSLSDRLQPPVDPSVFDSVSPSASTLSASDFVSEGPKSDLLCHAISSPSSMSVPPLSSSDHAIFSSQHSGFDHNAHLDTIASAASAAAATQYEEAAAFQAKYYHEHPTALRSSASASLSSSSTDTYSFAPTDSSSAFLSLMRPASLAMHDLDTSQCNEKKHEDMHALKDAITDARCSPNRTTTSRAPSRPASCSITSSGSVSACSTMTVPTTSFGTSFLTHLNADAVLSFDDERDDVASTNTPTNSGSGPVRSVAPQVPVQRQTIPETAQQLHTHEPNVRDTPPSLSVSNSSPARTVSSAILSANVSPLSGQTSTAKQAIQSPCEEAKRPRTDPEKAAEPRTSSESTQKRFQCPKCSRAFARAYNLNTHLSTHDPDPSRAKPFPCPYRSCRAEGGRSFSRKHDLQRHVASVHEWEPEPGIHGDSGDVGEGQETGGLASLGLGAPGKKFRCDECGRAFVRRDALRRHHCEGASAHAMLARKATIFEKPPPAYAMRTFPGDVVQRVALQLMNKTDPKVPYAPEMVKTSAASRSEGEPRSEPSRIQRNPSPSLATTYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PS26</accession>
    <name>A8PS26_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732405.1">
        <property type="nucleotide sequence ID" value="XM_001732353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PS26"/>
    <dbReference type="STRING" id="425265.A8PS26"/>
    <dbReference type="GeneID" id="5856711"/>
    <dbReference type="KEGG" id="mgl:MGL_0180"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0180"/>
    <dbReference type="InParanoid" id="A8PS26"/>
    <dbReference type="OMA" id="RIWESTM"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="190" mass="21560" checksum="BC68C5807173A4E9" modified="2008-01-15" version="1">MANYHLARSLLKQGMRLTQPGKTNMLYQVILKLRLQLWKARKRKEEAKIQKQIERGQDASQAREAAKEAERWGKAMAASEGVRIRDNVHVLKQTLKRRERSKEKSAKSWNERRKAEQEAQAAKQKRRMENLSSRREAKKTSGKSNKSVRSPSRARPGFEGSSRSFSSGHRKSASGSSSGGGNKSSRPSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSE3</accession>
    <name>A8PSE3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0242</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732467.1">
        <property type="nucleotide sequence ID" value="XM_001732415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSE3"/>
    <dbReference type="STRING" id="425265.A8PSE3"/>
    <dbReference type="GeneID" id="5856773"/>
    <dbReference type="KEGG" id="mgl:MGL_0242"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0242"/>
    <dbReference type="InParanoid" id="A8PSE3"/>
    <dbReference type="OMA" id="YWRTFET"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="8">
        <location>
            <begin position="72"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="485" mass="54503" checksum="6772240E842403DD" modified="2008-01-15" version="1">MMLIKKQALGQAQGVHATHRLFTMTRSSTASSLSIPAPSTASASDQDAAALGRFFYRNSMINEWANHPAHRTTLQQLIMFGRSARRNRTLLMQSADYLRRELTIRIAHRLRDMQTIPFVAMSNEQLDSIYQFYWRTFETLRRMSKIESDEQNQHLIDVVTHLLSERKSKLDLTAGICRECIYYMEPEAVNLFLARMLRSQISREVLAKQHIALSLMQVAPEAKRTPNVVGMIDTQILVARSVQQSFEFAKSSLARTYGWDESDARMPSVEIFGDLQAQIAYLPAHLEFIVLELCKVSMQATMNHHTKTGQVPPIRILIVDSASKDEVIIRISDLGGGLRSVQSTEADSKPRFPTNVTRARGPSLLPGISSLPPVNEAEDTLLWSFHNLGKELERMNIQLDTTATLDHSQLHADGAETPDPTSSYPGGDGLMRLSVLNMDSRSGLPIVKLYAELFGGKLEFRAMDGYGTDIYLRLPKNGTTKELHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSG6</accession>
    <name>A8PSG6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732479.1">
        <property type="nucleotide sequence ID" value="XM_001732427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSG6"/>
    <dbReference type="FunCoup" id="A8PSG6">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSG6"/>
    <dbReference type="GeneID" id="5856785"/>
    <dbReference type="KEGG" id="mgl:MGL_0254"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0254"/>
    <dbReference type="InParanoid" id="A8PSG6"/>
    <dbReference type="OMA" id="PTNMVHL"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="223" mass="24825" checksum="687C7DDE56143059" modified="2008-01-15" version="1">MRVLKARAALLSDYEVLQLIRENEAEQRNDARNRKEQLDTDMDVPSNLRTMQFEMISALSQPYRPCAFQRAEQIRAFLDDLNARGYVIPDDRVLAGEPGLTKTERLQLVNHAPSSVVELHTLVEELGQRMNDDQIAEILQCVTTNLPITDAAVTMADSAVTETDADTGAGAASHQMEEESHAIDEDMTMNEAEMEAAEDAFPEEEFEHEEPGAGMDQDGGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSH2</accession>
    <name>A8PSH2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732482.1">
        <property type="nucleotide sequence ID" value="XM_001732430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSH2"/>
    <dbReference type="GeneID" id="5856788"/>
    <dbReference type="KEGG" id="mgl:MGL_0257"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0257"/>
    <dbReference type="InParanoid" id="A8PSH2"/>
    <dbReference type="OMA" id="KRMQAMS"/>
    <dbReference type="OrthoDB" id="2528184at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="917"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="617"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1223" mass="134805" checksum="533A5AB24299FE5C" modified="2008-01-15" version="1">MEVEAQRGRQEQIRSAKRALRQFQRRRAQEQSKRASRTLRASLLVKGADTPTLLTQCFTASNAPESIARESAARATDKSRRRRSRPSVIYFDNNSAPGSRQSSQTCFPNMGGANGPCHSRKQSSISSSRLPTMTAGHRLSLARQSLIDQQRNSLVSSPSLNHCSPSRRRSRHSRQFSIGTRGEGFEVMSGQPVKSVEPDQPVRRASIHRRASRVSVRFSSLEPASILFGNPSVQKPLPPIPSDWKAGLRDTDSPVEEEDRTTALEKLEGRHRPSMLITPNESPTSTTASPSLSRPIIPSWLSLGDSSSPSKNLSKMSTASKRETFIEPLVEEVNVGSSSLEPVVRDESTPRPSDPDVFGISPESRKSPLRPLKLGTLSPVRRPTMRASPASKSPKRVSSITYKASHDPDSSLEKVTTPTRSWSESLRKHMPNSSRDAYSTVTSWTASDQTQSLFSPDSNVSGSPGATSIDSTDHTVRKRGFRMDESLSDSLQHQLTTLHSQLDEERERHQQEVISLQRELEEVREVMGSQLISLRNAKESAQKQASKLEAQIHDMQMQLEDTSGERDMYKEDIVDWRSRCSDLEHTIQSQQLRLNQERTWRRVAMKRMQAMSTRLRAGTATGSDVSTASTDTSHSSALPSMPDLPELPELPSEDEAGLWTQRVARQLSKHAPNSSNAPELAPETIKLLSDMREQILALYSALRLEESNHALTREQLHEAKERSALVESEMSNRMPKSEPSMPELPLPQPSDSVTLDMSTPIVTHVEEGSHVPTNHDTTADILFPPPSDLPNASQDEQALIGLGFSSVPDSSMPQLYSNEPSSCLDSSYRAATEGSFDRSANKPMYTSDHAVAASLQESGDALPLSESGTLESETNQLNPAPFVTTNEPAWPEVEASFSTDTDPHHTKVQSLDLDLECGGDDSAWVSEDEDEQASEVDTDDKSSPPTPRPEFIPEWSFDQAMFEANRDVRSYKESGCHPQNRYARRGARRVRKTPVEDFFGVLDVRSDSVKPLPMPDYALDMPPVDLNKLAPAFEYQPSVLSSPHTTAAVSDGSKFGGITRAPLLDEPWQSPKSRGQASQQQQQPISYGKEEKTSSDSVTPNNGGGTAQLVSQMLSGWVSARTPETCIEEESYPDVQSYDVASPVFSSISTPVPVDSHLAPSIPAPSTPIPRSPGYDARSPVAPGHMRLIKHNPLTRIPVPTPIWLLNFERTTDVPNAAPSFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSL0</accession>
    <name>A8PSL0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vps52 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732501.1">
        <property type="nucleotide sequence ID" value="XM_001732449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSL0"/>
    <dbReference type="FunCoup" id="A8PSL0">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSL0"/>
    <dbReference type="GeneID" id="5856807"/>
    <dbReference type="KEGG" id="mgl:MGL_0276"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0276"/>
    <dbReference type="InParanoid" id="A8PSL0"/>
    <dbReference type="OMA" id="PIRTSMT"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="1">
        <location>
            <begin position="51"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="506" mass="56553" checksum="3C5D1871BDADD8F5" modified="2008-01-15" version="1">METTAALAPALAEATRTSGKGIAETCSDAIQRMDHGQDAVMQARMPELYALAEQVTSSRASLAKIRTDIERFHTQLHTASEHIGKLQDRSNTLNEHLSEQETNASTLTKWIEGAVIAPSTVRLLRDTNVDDNFHGWVKAVHMIEHTLRTLNEYEATQDSTATPGSARAQARDVAEQCKNLAIGKIYPYLVRLFEPIRTSVTTTLPILQSSVLLPHNQPLYQFLAMHAPRVAIEVQLAYINAARLYYETAFRRYVRELRRILQRWIEPASLVASAHKHPDAQYAAERQQYARPLTDVAAVLACQSEDVNFRASPEHLFHTLALVFLDTACTEYAFLARFFAGTEMRHDVYDASGVPTYNLLSLSPEEERLHESIVTRESWLQVMEPAISYFSEFHDAVLMMPSAPVLQHLTISNLTQSLLRVAQSRRCLIPELESVLMRHVLETWPLVAKGLDAEVDALKAVAVGARLSAAPRSSGAAGFFDRWSTLAMTTDLSRINASDALHKWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSM4</accession>
    <name>A8PSM4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_0283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732508.1">
        <property type="nucleotide sequence ID" value="XM_001732456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSM4"/>
    <dbReference type="FunCoup" id="A8PSM4">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSM4"/>
    <dbReference type="GeneID" id="5856814"/>
    <dbReference type="KEGG" id="mgl:MGL_0283"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0283"/>
    <dbReference type="InParanoid" id="A8PSM4"/>
    <dbReference type="OMA" id="WPRCTAQ"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="460"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="817"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="881"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="886"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP45294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="959" mass="105181" checksum="43F642FEBBB37E70" modified="2008-01-15" version="1">MSTTYRNVRPLQTAFMSSGLVSKRRRSFLPELQTYSRESMHTGDESSQCMESMRSAPSLASLSMDSHQSHLPRHTHAFHHASHQPRPLREVVEAAMADRSFNVSRRPAAAVMPDTPMKPSAGMTEVAKSARMHRRGCSMGGAIPSMSPLFATMPKSPPAPFSGFTSTTASKATTSNTRHLGRRAGHMRSASERIPGTRNHLYFNDIPVRPAVADPDDVFESPSESPIRPSIRQGPAVAESLSDSLPAIRRDHSHTRAPSARTSRVLPVCPLNIPSDRSNDKLIPRPASPLEDAPMQDSAPSSMDSPNNVFARRQPLLSAARTRPSIHVAMHDDGSDPDSNSVGDSPYRHEDTWIESTPTMARVAMPRCGTSDVPLLCTQPDLLNSPNTPTRDGFKWYEATRSPEAQPVPKGTGAGKMRPRHSQPTYMHTPPTRAESTKPVHSAPAGRYRPSRTSQFEEHFAVEGVLGTGEFSEVIKVREKATGYLSAVKRMKRPFLGPKDRVRRLEEVDALRLLKEQRASWRDPWFGAEGVMDLLDAWEEDGYLYLQTELCPLGSLAFVLAEYGRQVGALDEARLWKILAELSAGVYFIHQCGVLHLDLKPANILITEVGTLKISDFGMATRWPRCTAQEILAGSHLATHNNASGPSMNDASDTSFSPIQSHGPFALSGATVTDSPAFSQTNIHATVHRPRRRPTRIQRRPSPVLVLEREGDREYIAPEVIFDSKYGKPADIFSLGLVLLEAACSVEIPDNGAPWHKLRCNDFSDVSFDAISPALQGIITSMLCAEPSARPTAAELVDMPVLETVRQLMRRGLSADELDQLPSHSSRPSAPAPYPLPPSKYYEAPHTGSLDANRMVVKIRGALIQENESTFLAEVLQVADARDTSSPDTSTSLMTEDSHYQHPSSSQNLHAAHHPSSSCTHMSPRVVPVCSSTILDPATCFQDHVASSMDIDKPFSVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSR2</accession>
    <name>A8PSR2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_0302</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732527.1">
        <property type="nucleotide sequence ID" value="XM_001732475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSR2"/>
    <dbReference type="FunCoup" id="A8PSR2">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PSR2"/>
    <dbReference type="GeneID" id="5856833"/>
    <dbReference type="KEGG" id="mgl:MGL_0302"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0302"/>
    <dbReference type="InParanoid" id="A8PSR2"/>
    <dbReference type="OMA" id="TCAHKAN"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="29"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP45313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="359" mass="39487" checksum="9A6C64770FBC38A0" modified="2008-01-15" version="1">MQLLRSVSTLTAQTPRLTSGPKKYGGVYTATLIPGDGVGKEITDSVKEIFDKLNVPVEWEQYDLSGEMQGNDSLFQQAMDSLRRNKVGLKGTLLTPTGAGSHNSWNVAMRQQLDIYASMVFCKSLEGFPTRHKNVDFTIIRENTEGEYSGLEHSPSPGIVESLKVSTRFKAERIVRFAFDFALKNDRKQVTCVHKANIMKLGDGLFLNTFRRVAEEYKSAGIKANDMIVDNTSMQLVGRPDQFDVMVMPNLYGNIVSNIGAALVGGPGIVPGANIGREFALYEPGCRHAAKDIMGTNKANPTAMILSATMMLRHFGLDYQANQIASSVYRVIAERKVRTADMGGNSTTQQFTQAVLDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT38</accession>
    <name>A8PT38_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732587.1">
        <property type="nucleotide sequence ID" value="XM_001732535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT38"/>
    <dbReference type="FunCoup" id="A8PT38">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT38"/>
    <dbReference type="GeneID" id="5856893"/>
    <dbReference type="KEGG" id="mgl:MGL_0362"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0362"/>
    <dbReference type="InParanoid" id="A8PT38"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="5">
        <location>
            <begin position="79"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="4">
        <location>
            <begin position="423"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="919"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="944" mass="102935" checksum="13CFA690CE3AC5BD" modified="2008-01-15" version="1">MNTADVVSVSNAQEQREALMNALERIRHLKDSKLENQRAPAQLLVAIEATLAERANTQPQEPQQERQTEPAGPTQYLLALESLLSAENTSADVHASSVYLLSIVLPHVAPGVVRAKSHALLGAVAAPLADPHGGAAENMNARLRASLGVVESLLHIVPVRERNILERERTWLAVWDLVLGLCIDARPKVRRRAHELVTHILSEPAWEHAHPYADRTMMWAARLLHGVAAARGVSHSKGGHPHLRAPTVEYDKHRGKAKHAMSAAAERQKQAVDGAASTGIWICALLQTIVPAVPVASTMPLVHELLALPALQNPFLTVAVYDVFSALFRTPRVERSLDMAVAPVERHTRDVSLLRHTLDELCKTTNVPAHTDVQTLPAYLGVLEACMVAYSAADLDSAWSLVPTLWHSSMTLALSAQSDASRASSDVRSAGRRFLQALAHYCVPDHAVADALKAHNADEVPLSRMISSLREALGKHALRYTHTRSDILHILASMLSRLRYPLEVGGPPPAEPLLMQAVVDVAALRAHRHFDARPDADAVLGSAISACGPRVFLSYLPLDLLDAKTGRPNTQGGVRGRAWLLPLLREHISNTELAHFVEELVPLSEALFEVRVQAEQPSDGSAPRPVEAKVMEALIEQIWVCFPGYCDLCRDVDTSLTPHVLELLINVLRTQTNLRPAVLKGLELLVQRNESLISSQVDAAQLQRQFGVDQAAGRRFLEHLRAMSGVLLAALFQLLTELPSQSRGFVMDCIATYLAILDSRSVAATFEKVAAMLKQSLATYVPSAPAPGMPEANSPRYVPPVPHTMLDLFIALVPYVKRENAAALFDACMQVLTVDDSGLQKKAYRALSRLLSTSEAPALRARKGSPAALVTQLLEQDVPLGAVRDRLALFRALVPYMPDADLGSLAALVPEAVLGTKEANQGARRRSLLPARRDRPPHGAWRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTE9</accession>
    <name>A8PTE9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 16">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MGL_0413</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 16"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732638.1">
        <property type="nucleotide sequence ID" value="XM_001732586.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PTE9">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTE9"/>
    <dbReference type="GeneID" id="5856944"/>
    <dbReference type="KEGG" id="mgl:MGL_0413"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0413"/>
    <dbReference type="InParanoid" id="A8PTE9"/>
    <dbReference type="OMA" id="DVKPHMI"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12 15 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 16" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="19">
        <location>
            <begin position="427"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="20">
        <location>
            <begin position="673"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1141"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1082"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1148"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1190"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1254"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1281"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1311"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1328"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1345"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="15">
        <location>
            <position position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EDP45424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1376" mass="155266" checksum="C1A52B531086794A" modified="2008-01-15" version="1">MTTSTEAGVASPAPTSRPAPKSASDTYQKLSQLEHVLRRPDTYIGSVERRTETMWVYDVAKEQMAYRDTSYVPGFYKIFDEILVNAADNKVRDPSMDTMKVTIDKDAGTISVWNNGQGIPVEIHEKEQVYIPELIFGNLLTSSNYDDDEAKVTGGRNGFGAKLTNIYSTEFIVETADKQRELKYKQVFSNHMHDKDKPKITKNTRKEEYTCITFKPDLSLFHMDSIHPDTEALLMKRVFDMAGTRVIRPHGGNPVPRPTIVYDASEDHGRLWEVGFAVSDGTARQVSFVNNIATIKGGKHVDHVESQIVERIMEHLKKGKKDAPIKANHIRQQLWIFVNCQIVNPTFDSQTKETLTLKPSAFGSKWVMPDDFAKKVLKSGVIDNVQSIVQYHQDRQLQATDGRKRSRVSVTKLEDANWAGTKRSAECTLILTEGDSAKGLAVSGLSEVGRDAYGVFPLRGKLLNVREATYDQIKKNTEIKNIKEILGLQHGKSYSTVDGLRYGSLMIMTDQDFDGSHIKGLIINYLDHFYPSLLKIPNFLVEFITPIIKATKGQEVRSFFTIPEFEQWKATGDGGRGWTTKYYKGLGTSKPYEMKEYFRDMDRHMLSFDTIRPEDHDLLDLAFNKKKADDRKEWLRQFVPGTYLDHRIRNIPISDFINKELILFSMADNIRSIPSVVDGLKPGQRKVIFSCFKRKLKTEIKVHQLQGYVSEHSAYHHGDQALTMTIVGLAQDFCGSNNVNLLMPNGQFGSRSMGGKDAASARYIFTAVPRITRLMFHADDEPLLNYLEDDGQSIEPEWYAPVVPQVLLNGAEGIGTGWSTFVPNYNPREVVDNLRRRMAGEEYVPMNPWYRGFVGGIEPAGPERFRVTGIARQLDERTWEITELPVRVWTMTYKEWLEERVVGSDKTPAVLREYKEYHTDTSVHFVVELNPRGMEEIERVGPDTFFKLSTMLSTSNMVLFNPEGKIKKYATPQEILEDFYFVRLGFYQRRKEHLVDQLKLVYDRLSNQARFVSMIIARELSVSNKKKAAIVEELRQLKFQAFPKVEAKAKSVTEEAVEDQEEPDEPANSNTDYDYLLSMAIYSLTQERVERLLKERDHTETELKILLGRSPQNLWDEDLTAFLEEWDEKLAEDARNASMTTTHVVKDLKKRRAPAKRPKKEEGSVSPVKRQPATSKTVAASPADETSAHTSAPDATQPTTATTTPFTTTTMPEPVPETKPTTFHQVPLPQAAPASPLKHDRVDDDEDELALPTPKTTARPRSTTTKAPSKTGSARATTKTSTRGAAKAPARATTRASAKRSGKESSPEEPTQPTQPASAAAAPPPPRRATSSRAAAKARPTYTLDSDEEGAHEDPNDDSVALDDMDEDDSDDDYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTG6</accession>
    <name>A8PTG6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0421</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732646.1">
        <property type="nucleotide sequence ID" value="XM_001732594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTG6"/>
    <dbReference type="FunCoup" id="A8PTG6">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PTG6"/>
    <dbReference type="GeneID" id="5856952"/>
    <dbReference type="KEGG" id="mgl:MGL_0421"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0421"/>
    <dbReference type="InParanoid" id="A8PTG6"/>
    <dbReference type="OMA" id="HLNTTEY"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01200">
        <property type="entry name" value="WHEPGMRS_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00458">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="14">
        <location>
            <begin position="649"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP45432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="712" mass="79713" checksum="DFAE126CD3188F7F" modified="2008-01-15" version="1">MASPFPRVPAPIEGHVRELNDRVLMKVTSDKHPATILPQDDEENVLVTSALPYVNNVPHLGNIIGSTLSADVFARYARTQNKNTLYICGTDEYGTATETKALEDGVSPQALCDKYHALHAQVYEWFQIGFDYFGRTTTPRQTEIAQDVFRKLYENGYFEERVMRQLYCASCERFLADRYVNGICPKCDYDDARGDQCDKCGQLLDAVELKEPKCKLCKGTPQERDSKHMFLRIDALQPQTEAWASEMSKKGKWSSNGTFITESWFKEGLRPFSVSRDLKWGVPVPLQGYEDKVLYVWFDAPIGYPSITANYTSEWEKWWKNPEHVRLYQFMGKDNVRFHTVIFPSCLIGTKDPWTMLYHINTAEYLQYEGGKFSKSRNIGVFGDRAKDIGVSPSVWRYYLLSTRPESSDSQFVWHDFVTRNNSELLKNLGNFVNRILTFMKKYEGRLPEAPQGLRLGTDGPLSTTGDGTVWGDLVAKFVADVNAILAKYVDFMDVGKLRAGLNTMMELSARGNLLLTEAGLDNTLFAEQRAKCDAVILLATNLIWVLTALVHPFMPLTSDQMLEQLNAPPRALPKEQAFALDLLPGHMVGKAAHLFKNIDEKQAAAWKAKFGGDSSAADEKPAMSKKQAAKARKAAEKEKAASLPQTPAVLDLDARVKTQGDKVRTLKSSPNTPQGEIDAAVQSLLSLKQDMQAAVDAALAEQAQSSLQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTS3</accession>
    <name>A8PTS3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732695.1">
        <property type="nucleotide sequence ID" value="XM_001732643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTS3"/>
    <dbReference type="STRING" id="425265.A8PTS3"/>
    <dbReference type="GeneID" id="5857001"/>
    <dbReference type="KEGG" id="mgl:MGL_0470"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0470"/>
    <dbReference type="InParanoid" id="A8PTS3"/>
    <dbReference type="OMA" id="QHVANEH"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP45481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="245" mass="27705" checksum="E862C4574E65E238" modified="2008-01-15" version="1">MGASSEDLTSDYHDLAKSFEQLGMLETGLTSDLQQTAKALDDFADLEARFTFRVLDDVITMLHAKQAFIGSHKTLLKHRENKQLDFEGLTDYLHTAVTERDRLASLGTPDGEPVHGNVRGVGLRGYMRHMVDRVWGVDEEQARIERMQRLDGRIDELQDAVSLSHKQSQAFNQHVANEHDIYELGRRQEMLQTLRLYTEGNVHLYEQGVELFDRLIASLEEGSSDHTNTDDAAAKQEVSLAHSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8PU16</accession>
    <name>A8PU16_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732738.1">
        <property type="nucleotide sequence ID" value="XM_001732686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PU16"/>
    <dbReference type="GeneID" id="5857044"/>
    <dbReference type="KEGG" id="mgl:MGL_0513"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0513"/>
    <dbReference type="InParanoid" id="A8PU16"/>
    <dbReference type="OMA" id="SENATWK"/>
    <dbReference type="OrthoDB" id="3364662at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727083" evidence="2">
        <location>
            <begin position="28"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="319" mass="35232" checksum="A638A2BAC7161656" modified="2008-01-15" version="1">MSRMLFGQLWMAVQCLLLKVFSHMRWCSPVWFGPEALQRDLDKCISNPGMYKSDVLRSFMTCRHWSLDRHSQGKSLTWRDVLSAACPSQDPVFQRATKQAASQLESLYGAHLYEARLEKRTWTIEEPISMDHRASLLHKARASLAPYNPLEHISDVLHAPAMLAPLHETSSQVSNFGSNSLLARAEAAFMWESDEDAASDSGTVSITDDSELEGFGDDQDNTTDGYDGGDSVDSADGTLDQDPSDSNESSTTSHPSDETGSSTDIADQRTSLSTSSLAPASSQPTSQTNESKRNSSQSRRPKTAYPDFLPPSKRVRRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUD8</accession>
    <name>A8PUD8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_0664</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732071.1">
        <property type="nucleotide sequence ID" value="XM_001732019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUD8"/>
    <dbReference type="FunCoup" id="A8PUD8">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUD8"/>
    <dbReference type="GeneID" id="5856377"/>
    <dbReference type="KEGG" id="mgl:MGL_0664"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0664"/>
    <dbReference type="InParanoid" id="A8PUD8"/>
    <dbReference type="OMA" id="SQMWANY"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP44857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="81" mass="9497" checksum="2C11424A48CA7F4E" modified="2008-01-15" version="1">MPPAIENPYEERQTLLLERIIKNVDLLNEALMEMNRSFADINNHNQDITIVAEMWNGYHRNVDFNLQNMESNNTASNHHAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUN0</accession>
    <name>A8PUN0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0723</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732130.1">
        <property type="nucleotide sequence ID" value="XM_001732078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUN0"/>
    <dbReference type="FunCoup" id="A8PUN0">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUN0"/>
    <dbReference type="GeneID" id="5856436"/>
    <dbReference type="KEGG" id="mgl:MGL_0723"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0723"/>
    <dbReference type="InParanoid" id="A8PUN0"/>
    <dbReference type="OMA" id="QHYGEHK"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP44916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="152" mass="16896" checksum="A58ABFE22A5D118F" modified="2008-01-15" version="1">MSSEQTYIMIKPDGVQRGLVGKIIQRFEDRGYQLVAMKLVHAGEDHLEKHYKDLKGKPFFPGLIKYMSSGPVVAMVWQGKDVVKQGRALLGATNPLASAPGTIRGDYCIDVGRNICHGSDSPESAKAEIALWFGKQDATIPYKRAVDQWIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUZ3</accession>
    <name>A8PUZ3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732211.1">
        <property type="nucleotide sequence ID" value="XM_001732159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUZ3"/>
    <dbReference type="FunCoup" id="A8PUZ3">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUZ3"/>
    <dbReference type="GeneID" id="5856517"/>
    <dbReference type="KEGG" id="mgl:MGL_0804"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0804"/>
    <dbReference type="InParanoid" id="A8PUZ3"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="375" mass="41134" checksum="BDF155EAA1EAEB00" modified="2008-01-15" version="1">MRLPGITYSSMQSETASSRPTTHMMGGGMSQDGVFSNLNAKPETRRSAVDPHDRGDDDDLADDTPPPTYEVAAADAAPTYWESNVFGGSSLADSEGVWSENSAYVGEVSDMLQDGMMVGTIFAFLWNLFVSTSFQFIGFVLTFLLHSTHAAKFGSRAGLGISLLQYGYDLRLTVQSSLESVSSQENGNDDNNEDNMPSSGAIQRSNIGCDLVMALGIFLFLDAIIKFYLLYRKSSKIVAESRRQERETVTLTNDNNSPASEEPVPFVARFASWIRSGPIALISETVGNIQRSVSHDISVFMGDHGAHSAEDYVIRPGYGFDNYPIIFSLRDSALHANMNEEEFAHHLGLTDPFTGRVQSFAGNEPAHELRSVRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVA1</accession>
    <name>A8PVA1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731559.1">
        <property type="nucleotide sequence ID" value="XM_001731507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVA1"/>
    <dbReference type="STRING" id="425265.A8PVA1"/>
    <dbReference type="GeneID" id="5855872"/>
    <dbReference type="KEGG" id="mgl:MGL_0827"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0827"/>
    <dbReference type="InParanoid" id="A8PVA1"/>
    <dbReference type="OMA" id="VNTREYW"/>
    <dbReference type="OrthoDB" id="3343842at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="251" mass="27792" checksum="15DED8C42F9B684C" modified="2008-01-15" version="1">MVMMVCRFQHQGHTVNTREYWASSRIPDNVRDWIKERVSEGRDQKEIVQMIHEHQKNAANIPPTSPAFIPPGVQITRMDVYNIIKRHKNLQAHEHESSTQKLNATSDSAQPNDADTSHLPLTTLEAPDSSSVSTPTPLAITTDTRRAVDTSEIDHAAAAPYPILSTATQLSPATPEEAVSFAQQWSDLLTELQALQPQMMEYALTAGTTRQPNTTAAWSHAIAQLTQAWYVACNLLDRPVLPSQPPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVB1</accession>
    <name>A8PVB1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731562.1">
        <property type="nucleotide sequence ID" value="XM_001731510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVB1"/>
    <dbReference type="STRING" id="425265.A8PVB1"/>
    <dbReference type="GeneID" id="5855859"/>
    <dbReference type="KEGG" id="mgl:MGL_0830"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0830"/>
    <dbReference type="InParanoid" id="A8PVB1"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="272" mass="29755" checksum="4A26C474C0C17834" modified="2008-01-15" version="1">MALSLRLRPHPWPLPHRYSYTALAPTSTSSPNVPVLNESTLVTRTPARGKTGSVSIHRVQSATVPGVEEFVEAGGVSGGGRDSILYPPQREPYTPTQMKLRTPVPAPVYEPRPPSVRSKRTTQSQASLQHKVAFDEFHASRGVRLLRGSLGPVNNVPMMLKAGYRHVYVSRSFALDHGFIPVDTTPGTYGYNGITNLGKWPVQVGSKAVPLTVMLAEDSYFPVILGRSFMEKRGVRTDPIDMTSVIFMDNGERADVEVVVVRDELGNPVAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVC5</accession>
    <name>A8PVC5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_0834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731566.1">
        <property type="nucleotide sequence ID" value="XM_001731514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVC5"/>
    <dbReference type="FunCoup" id="A8PVC5">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVC5"/>
    <dbReference type="GeneID" id="5855863"/>
    <dbReference type="KEGG" id="mgl:MGL_0834"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0834"/>
    <dbReference type="InParanoid" id="A8PVC5"/>
    <dbReference type="OMA" id="WGPAVQN"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="5">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="141" mass="15904" checksum="2A37A4D098CE4D3B" modified="2008-01-15" version="1">MFLPTYFARTAARSVTLARFASTSARRVAPPPRDNIATPKAFLEAISKPRRDLANNSTCVSAVGEDWDAMFALNSEKLKGAGVPVKDRKYILWSLEKYRQGERPADFAYDVKKPKKVRGWGPRVQKGIRVRGMLRHGEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVH4</accession>
    <name>A8PVH4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731599.1">
        <property type="nucleotide sequence ID" value="XM_001731547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVH4"/>
    <dbReference type="GeneID" id="5855905"/>
    <dbReference type="KEGG" id="mgl:MGL_0867"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0867"/>
    <dbReference type="InParanoid" id="A8PVH4"/>
    <dbReference type="OMA" id="FQVWLEY"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40543" checksum="E97267B71E74D456" modified="2008-01-15" version="1">MGTQAQQSGTGAQFHEGNPRPTVVSPILSEIREDGAEEETFQLPTKYYAELDSIRIPMHMPYNQEDFQNWQNLQKQSVHRLYTNNPEQVHSRPLDQLVSKPAGINSEDARKTPLHDMMGWSIMNTNSEKMTVPGNTDPLTLNKTESRGWNEPWSFKNALGADSNVKVAGNTVVGAGVRTSSRSASWHQKFVTFLLRNPFVPFILRVINIAVLSSTLAVGVRLRKSLHDVDLEWAVGMSPILAIVFTPLSLAYALFQVWLEYRSRPIGLWKASSKLGYMALELIFVCLWSAELSLSFDNYFTSTIACMSSSSPFYSHIQPVQEHIANKSTICDLQISLICLCFISVMVYLIVFLILARFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVU2</accession>
    <name>A8PVU2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Phospholipid methyltransferase</fullName>
            <shortName evidence="17">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_0956</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Endoplasmic reticulum membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Mitochondrion membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="17"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731688.1">
        <property type="nucleotide sequence ID" value="XM_001731636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVU2"/>
    <dbReference type="FunCoup" id="A8PVU2">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVU2"/>
    <dbReference type="GeneID" id="5855993"/>
    <dbReference type="KEGG" id="mgl:MGL_0956"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0956"/>
    <dbReference type="InParanoid" id="A8PVU2"/>
    <dbReference type="OMA" id="PTFWNIA"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="17">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="192"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="206"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP44474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="252" mass="28330" checksum="8802E15C76BCC23E" modified="2008-01-15" version="1">MSEFVSTWFTPPVGVQKGWVDFSKSSFWIAVVSILFNPTFWNIVAQNEYRNKSITRLLGGRRYLGCYLLAFTIFTLGILRDHLYQRALEEQPVHTMLMHPAVRVLAVVLIASGTVFVLSSMWMLGITGTYLGDYFGILMDHMVTGFPFSVLNDPMYVGSTLNFVGVALWYARPSGLLLSVLVWVTYRVALCFESPFTANIYREAAEKRKEKPVQEARRAPSAAAPAISSHEDGPSSSHAPYAARYQTRQRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVV4</accession>
    <name>A8PVV4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0964</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731696.1">
        <property type="nucleotide sequence ID" value="XM_001731644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVV4"/>
    <dbReference type="FunCoup" id="A8PVV4">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVV4"/>
    <dbReference type="GeneID" id="5856001"/>
    <dbReference type="KEGG" id="mgl:MGL_0964"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0964"/>
    <dbReference type="InParanoid" id="A8PVV4"/>
    <dbReference type="OMA" id="WNDNAIN"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004933">
        <property type="term" value="F:mating-type a-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001546">
        <property type="entry name" value="GPCR_Pheromne_A_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00900">
        <property type="entry name" value="PHEROMONEAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="392" mass="44122" checksum="470CF2B1A0596865" modified="2008-01-15" version="1">MPDVTLPIFALVSVILALLPVPSHWRARNISILALVFWLNVGNLNNFINRLVWNDNAINKAPVWCDISVKLMSMVTMGVPCAALRISRRLCEIASLRCIPESKDQKKKALQCDALWVTFLPIFYAALTIISQGHRFNIVEGQGCQPAIYFSPITIVIDYGMPLIASFISIIYSIMALFYFFAHKKNFESILSQSGSGLSTKKFLKMISFTLIDLILNFPTLLADFSLELTYSKILPFVSWSVVHSRFGDVWIYTSDLFDSPGGKRFLLLSLFSAWTLCATAIIFFLLFGFSLDARSDYDKAHARLKSLFRNRASGNTGSKYVGTLTSDNLSIENVLNQESVASNDLESQHEKVSDNGSAHSWTEFETVHSHASYDKHCQNQDISEEKNLRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVW4</accession>
    <name>A8PVW4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731702.1">
        <property type="nucleotide sequence ID" value="XM_001731650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVW4"/>
    <dbReference type="FunCoup" id="A8PVW4">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVW4"/>
    <dbReference type="GeneID" id="5856007"/>
    <dbReference type="KEGG" id="mgl:MGL_0970"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0970"/>
    <dbReference type="InParanoid" id="A8PVW4"/>
    <dbReference type="OMA" id="YNWDVAQ"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="186" mass="21198" checksum="A0FDB5DB7397D61D" modified="2008-01-15" version="1">MASTEAHDSQLRGIPTAPFVTDVAEFVGGADKDVMPTLKQFQDAISKYKFMELSTAQRRKGLEQKIPDIGKTLQMVEYLKARQTESEPLETTFELNDTLYARAHLEPTEKVHLWLGANVMLSYDIDEAIVMLQDKLATAKKGLQLANEDLGFLRDQITTMEVNTARVHNWDVKRRRDKKQRETLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVW6</accession>
    <name>A8PVW6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731704.1">
        <property type="nucleotide sequence ID" value="XM_001731652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVW6"/>
    <dbReference type="GeneID" id="5856009"/>
    <dbReference type="KEGG" id="mgl:MGL_0972"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0972"/>
    <dbReference type="InParanoid" id="A8PVW6"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="170" mass="18987" checksum="14BF5CCC17A86199" modified="2008-01-15" version="1">MPLEDVPRYRPRRLREQDQAGSSNARTPAGAVVSSSRLSSVQMKEEEDLKRVPRSDPYQPHEHLETKKTPGVTTPPGGAARNRTSSQTPGDPGARRSWSAKDNRKDRADVKTATTEPVRREELGVAPAAQRRPQAEQANKQPRHSTNADDLEKQFSSLSMQEKDIHTSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVZ9</accession>
    <name>A8PVZ9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731726.1">
        <property type="nucleotide sequence ID" value="XM_001731674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVZ9"/>
    <dbReference type="STRING" id="425265.A8PVZ9"/>
    <dbReference type="GeneID" id="5856031"/>
    <dbReference type="KEGG" id="mgl:MGL_0994"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0994"/>
    <dbReference type="InParanoid" id="A8PVZ9"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="78" mass="8478" checksum="31CE2BEA1E33EF78" modified="2008-01-15" version="1">MASIGKLYGTPGASKVMRVMAAAKINGLELELVTTKPVEDSHKPEFLAKFPQGKVPAFEGSDGFLLTESRSILRYSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWK5</accession>
    <name>A8PWK5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731864.1">
        <property type="nucleotide sequence ID" value="XM_001731812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWK5"/>
    <dbReference type="STRING" id="425265.A8PWK5"/>
    <dbReference type="GeneID" id="5856169"/>
    <dbReference type="KEGG" id="mgl:MGL_1132"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1132"/>
    <dbReference type="InParanoid" id="A8PWK5"/>
    <dbReference type="OMA" id="GKPMSAF"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 C-terminal" evidence="2">
        <location>
            <begin position="289"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="3">
        <location>
            <begin position="1095"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1266" mass="139802" checksum="34C9F2E74D4620B0" modified="2008-01-15" version="1">MQAPYERVRPRISELKASDGDDSWIDWPPAAKVVRAKPPSISHAQTTSSTTHAAKETLGASQSDYECSDDPKETPTNLSTPIRPIMGEILEREPASSSQPRDIEPMGNNGKPMSAFRRSRLERTKKDSSRKPPSPPRDELVPMQDASRDPGGGAPPEAMTSLMQDISLENESKVASMSYETRADELKDAESFFGKDVLEKLAQRSARRDPTHEQPLDKHETHPSAGWPSIERRATELDEEIQTNPPKSAQISDRDHWESFRQKYFPDEPDAVPAALEWTVSPNPTTTSSVRFDFHGHVTTDSRHTWAEAPDSTYLAGLHHHGSEQSVPGYTLDELLHLAQSSIASQRALALQVLQRISERYPSSQTGAPLSNSAQLALNADAHAIRARILLTSFWLLQDRHRSVRLAAVPCLDAACRAVSNVPDDPFILADMLTCANPDVNWLWPASQQDAWTPHSHAPPLHSPDASHLELLQHDWADALLRMHVLDALDTWLVENAAHPDAIVSILCMLVLHHQACAKALAQHPHLVQAVVQLGCTQRAWPVADESFPSMEAVLILLRMVQSNRDVASSLVDEGVIDPLLRYVLIPPRDVSSSQSSADAASPSAATNIIRQEHAFLFVTLRILAALGHYGLASTSIRELAVALSRLADWTQSLPNKVSADDIQWYSAQALYNVLNVWTHRAIQGPRHGDLGVNGPMVQAWAPLSEGFLTNAVGQSRPTSSVNGAIGTAMCHLAAWADCAKHCGIPWDRSSYEALLTTCEQFLRHAHASITSAADAFRSRNKQEIRASLQIVAQSVWMYAGVTRFAQMMGWSSLLELVTQYVHEVLGLPWNMTSTPAIRADGIASAQYTHVLTMCANITTPDVQIRLVGLLWSHESAHVARLLESVVRGFDQATWHILAPFFLDNIRTERIPSMIEASMLRDEHTSTLWKPDVAALPPMTDPRTGATLWTSPAAGLPLRADWPLLALDDLLHSGEARALNASNALPTSWDFNEADIVRASLRLAVYVAKFALTPSAFWWLGIYKVFLLEQVSSTAPEASGAATGRDLYTDASVADPMRSLMDMADQLSIQSAKHMRQEPTLEDATASIHGPGLPFYQMYTDLMGLYDAVSMHHPLFAKAIIPPLAMTYAPDYRRLLWNDYAAVLPGITMNTLDAPVVGGKRLDAYLWPCETDEIVLTRYADALARGTVSPNQPFLYAVALHHVCGALWHTIEDEWAFERPISATLQRSIARRVLPNAQVSNVIMEYAPRKGVAPTARRWSLQAQWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWV4</accession>
    <name>A8PWV4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731962.1">
        <property type="nucleotide sequence ID" value="XM_001731910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWV4"/>
    <dbReference type="FunCoup" id="A8PWV4">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWV4"/>
    <dbReference type="GeneID" id="5856267"/>
    <dbReference type="KEGG" id="mgl:MGL_1230"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1230"/>
    <dbReference type="InParanoid" id="A8PWV4"/>
    <dbReference type="OMA" id="SDCKKTW"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36102" checksum="9EC2D17959F93FF3" modified="2008-01-15" version="1">MWGLTSIFPPAPSWNVEQVPDQTGRIAIVTGGNSGIGLETVRELLRKNAKVYLACRSEERAHKAMDELQRNQLPGKIEFLRLDLASLHSIKEFSEQFLAKEQRLDMLFNSAGVMNPYVGPETKDGYELHLGTNSLGHHYLTQLLVPALQVSAKASPDRPPRVCFTSSIAHRATSPKGFDPTDPTGLHTYCYMPAHNRAYGTSKFCNILSANWFQRNLGAQNIVFTSCHPGILKTGLVREWNQGFNTIMMPIIEAAIFYPQRMGCITQLYLNTAPEAATKGGSYFAPWARQVDPLPLARDVGVQDTFAKWVDEQVTKHMGQPVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX39</accession>
    <name>A8PX39_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731132.1">
        <property type="nucleotide sequence ID" value="XM_001731080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX39"/>
    <dbReference type="GeneID" id="5855445"/>
    <dbReference type="KEGG" id="mgl:MGL_1315"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1315"/>
    <dbReference type="InParanoid" id="A8PX39"/>
    <dbReference type="OrthoDB" id="3365235at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="83" mass="8622" checksum="B556564B1F2BD7A5" modified="2008-01-15" version="1">MIDIAPSTSSMVIHSAENHRSKKNLSQVSTTPKPTTLITRTVKGKALTVTATSISVGLDCGNDNIFGIEVCANGSGNGNHILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX44</accession>
    <name>A8PX44_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731137.1">
        <property type="nucleotide sequence ID" value="XM_001731085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX44"/>
    <dbReference type="FunCoup" id="A8PX44">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX44"/>
    <dbReference type="GeneID" id="5855438"/>
    <dbReference type="KEGG" id="mgl:MGL_1320"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1320"/>
    <dbReference type="InParanoid" id="A8PX44"/>
    <dbReference type="OMA" id="LRFHHTM"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="77"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="258" mass="28482" checksum="125364CD1A51754B" modified="2008-01-15" version="1">MVDTVFPEREEQPSAFSESLSDECNKLQTTEANQSVVPSSKKRKRKQFATKTTFDEHGAAHTTPLSSQESSDSNLKYIVFVGNMSYDVAADELAKHMEETCGEKPKVRLLTKKADPALHEKLSNSKKKSIAKGKARDPSAPVSRGCAFVEFTNANSLQKALRFHHTMFRGRQINVELTAGGGGKSERRTEKIKAKNAGLDKERRKLFEKYVKPGAEAHKQKQLKGQDGQRASTSAENSDRSTSSKFKYASGANAVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX76</accession>
    <name>A8PX76_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731169.1">
        <property type="nucleotide sequence ID" value="XM_001731117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX76"/>
    <dbReference type="STRING" id="425265.A8PX76"/>
    <dbReference type="GeneID" id="5855476"/>
    <dbReference type="KEGG" id="mgl:MGL_1352"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1352"/>
    <dbReference type="InParanoid" id="A8PX76"/>
    <dbReference type="OMA" id="ELLTQTW"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="244" mass="26305" checksum="4366FB11B9C26837" modified="2008-01-15" version="1">MTLMQPVMPHVSTPTPLTWQQELLTQTWKPNRKSEKPKSATGSNPARGKRKDKLPSASSNVAAPSSAMTASGTTPPTPSSSGLTWQQELFQQSNRRGPTYDRAETAKDMETFGTQGSQLSKPTNTKVSADRNKSKNAPKGKNKNLTKVRDSQTPMTPSKIPISTKVSSSSSPLPEPLAYAGPEFHNSPSAASLPTPRFTQSRGVASATQLTPQTPPQRSESRRETVDHLLSQILASTSLPSTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXA3</accession>
    <name>A8PXA3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1379</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731196.1">
        <property type="nucleotide sequence ID" value="XM_001731144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXA3"/>
    <dbReference type="FunCoup" id="A8PXA3">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXA3"/>
    <dbReference type="GeneID" id="5855503"/>
    <dbReference type="KEGG" id="mgl:MGL_1379"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1379"/>
    <dbReference type="InParanoid" id="A8PXA3"/>
    <dbReference type="OMA" id="DERAHIP"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="185"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="335"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="518"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="702"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="900"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="1085"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1227" mass="136396" checksum="97F4E6FC057E3F3B" modified="2008-01-15" version="1">MSDEDLDGGFEDVEDDESIRAGSKTEVNEIDDDDAAKNTYERMAPEGGSASSHGTSSLYTLPSNEEIHGLQETSDLYMNNMFKLQLDEMLKYIHPSGGHKQAIEHLLRSLQACIMCVPKIDPQPLSKAVQELTSRVGHSVHIPLVEPVPREDPAYMIAFEPPEALNLVGSWPLHTVTRRVGEMDVDMEVVMPSKLFQEKDTLNARYFTKRAFYLAVILAYVEQNHAALGVRAEWLYVGGDPRRSCLVLRPTPEAHDLIKTHTVVRIHAAHAPGTFPTSRLAPNRNNMRGSAIGASDQDTASLPPTPIYNACIAAESLRLAHLVYLHATSEWCKGFAEACQLLKIWATQRGFGALHLLHEHDDKHATRRVVAGTDDARFVLCMVLAHLLHGEPKVTDTNMEAGSYPGVRMRTKLSPGLSSVQLFRGVLEYLAKNSFATPVWMKAQPSYGLAPATDISPASFAGVFERTLVDPSGCVNLFAHWPAASVDLLQLDAAQSMRMLSDGSDHFADLFLVPQCTPLQRFDETASMHLNLHARGSLVHRLDAGSPSLWAIRRVLDVSGHALGRRARVVAICTNPQKTCTTEQQASGGSASPKIVELGMWLNAEHAWHQVEHGPSPDSPDAAAFRAFWGSVAELRRFRDGRVRESIVWPVSTLAQRQSIPRQIVRYALTQHACAKRIRFSGDAFVGWLDVPTSLAQRVYSKDPSVHGFQLLQTAYDTLARELRAMDELPLSVTGVTPAADALRSMSVFVPGPRDVTEWGHDVPDVMTYVPVHDVIITMESSGQWPDDLAAIQEMKTALYERMADVLSRRMPGTKMQVVYDSDATAHDAIYDQTCLQILMPTGFAFALRVHHDREQVLLHRLLNDKHARARAQAALRRYDMRFVHAPTHHAALQALQDHFPALGPTVRFVRRWFASQLLSTHFRAEAIELLCVAVFLTNAHGPPTTGMHGFVRALDLLARWDWRETPLLIPLENATRLAHHRKAALSDGGSALPDETAPAFPAAQRADVEQHFRTIRARDPAFRHSTWVLATEMDLDSKAWTHSAPTAMVADGVRQLAKRSLHVLKQDTSISTPLVRMLMTPAVEAYDFVVHVQPSLHVRYAESIAPDSTHWLATRKKRVYANLDDTPLRPSVYGSEVRPGFDPVYEFVTMLQTIYGDAFVLFYDEFGGTVIGGLWNTAYTKPHTFKVSLPYTSRPHAKGVVLNRPAILAEIQRLGQGIVERIDTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXB2</accession>
    <name>A8PXB2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1388</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat TUP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731205.1">
        <property type="nucleotide sequence ID" value="XM_001731153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXB2"/>
    <dbReference type="FunCoup" id="A8PXB2">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXB2"/>
    <dbReference type="GeneID" id="5855512"/>
    <dbReference type="KEGG" id="mgl:MGL_1388"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1388"/>
    <dbReference type="InParanoid" id="A8PXB2"/>
    <dbReference type="OMA" id="HDSIVNC"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000503">
        <property type="entry name" value="Glucose repression regulatory protein TUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="342"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="466"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="523"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="565"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="50"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP43991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="601" mass="64900" checksum="C5A3329DECD7CDC1" modified="2008-01-15" version="1">MQEHIYELEKRHFEIVGHYEDEIKRLRALLDGRTLSGMHDMAPRRLSPVAVPMDARPLPPSVSGSQYDRDPRDLRDLRDLRDLRDLRDPRERMLPAMSSVSGDSSWPPTKRPKISGPPMPAESMRLKPEDREHKRATGPAEHADEESAPSAEPANEYRKTAASHSASSSAVDAASSGGAPSGNASALNSAPAATSTASLKGAGPTSAPNAASESHSPATNAPMASSRTDSHTSPSAVPGGMSGTTAGSGVSSMEETEHAAPLKKEGSDWAIMYNPNSKPQLDVNLVHTLVHDSVVCCVRFSPDGKYVATGCNRSAQIFEAATGTKTCVLQDTSAPVQGDLYIRSVCFSPDGKYLATGAEDRQIRIWDIAEKKIKMLLTGHKQEIYSLDFSQNGRILASGSGDKTVRLWNAENGTELHVLYTSPGLNYGPGVTTVTLSPDGRLVAAGALDTFVRLWDTKTGKLRCRLKGHRDSIYSVSFTPDGQSLVSGSLDKTLKLWDLTSIIKALDSLDDEISNSTLCKATFTGHKDYVLSVSCSPESRWIASGSKDRCVQFWDMKTAQTQLVLQGHKNSVIAIHLSPSNNLLATGSGDFHARIWSYEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXC6</accession>
    <name>A8PXC6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731219.1">
        <property type="nucleotide sequence ID" value="XM_001731167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXC6"/>
    <dbReference type="STRING" id="425265.A8PXC6"/>
    <dbReference type="GeneID" id="5855526"/>
    <dbReference type="KEGG" id="mgl:MGL_1402"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1402"/>
    <dbReference type="InParanoid" id="A8PXC6"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="121" mass="13824" checksum="3982803FB257BD54" modified="2008-01-15" version="1">MRFSWCVTKEKLLTNQSPPWGGVEYRDPSKLKGVTPTNKKYYDAYPFMALQPVGGKKLLELSRLVTDKVVMFVPRNMDLSDVSEAVKEVGDGFTVHVEEMWMGPRLKALSLIFEKQPNNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXF4</accession>
    <name>A8PXF4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731247.1">
        <property type="nucleotide sequence ID" value="XM_001731195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXF4"/>
    <dbReference type="FunCoup" id="A8PXF4">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXF4"/>
    <dbReference type="GeneID" id="5855554"/>
    <dbReference type="KEGG" id="mgl:MGL_1430"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1430"/>
    <dbReference type="InParanoid" id="A8PXF4"/>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="216" mass="24251" checksum="730C57C02DEE263E" modified="2008-01-15" version="1">MSKIQVSGVRSSVRDVLKGAEEKKRNFNETVELQIGLKNYDPQRDKRFSGTVRLPHVPRPRMSLCILADAADVDRAKLISLDFMTVDDLKKLNKNKKLVKKLAKKYDAFLSSDALIKQIPRLLGPGLSKAGKFPSPVSHAEDLEKKVTDVKSTIKFQLKKVLCLGVAIGHVQMTEDQLTANIMLAVNFLISLLKKNWQNVKSLHIKSTMGKAQRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXH8</accession>
    <name>A8PXH8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731267.1">
        <property type="nucleotide sequence ID" value="XM_001731215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXH8"/>
    <dbReference type="GeneID" id="5855574"/>
    <dbReference type="KEGG" id="mgl:MGL_1450"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1450"/>
    <dbReference type="InParanoid" id="A8PXH8"/>
    <dbReference type="OMA" id="CDYDERY"/>
    <dbReference type="OrthoDB" id="3345311at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="229" mass="26050" checksum="ADDE9BD242DDEC77" modified="2008-01-15" version="1">MQAYERAPKAWDVFARYFEQMPLDLLRLVGEQLTPVQRGKLSRVRERRRCFAKSTAPRKLSAEVQRLAQPQLWHNLVARAEGEQDEEDGDTMEVERECESDDHDRGDSIREGNDHMVDANKGQTKNDMQGQERNAKKEQDGDMNTAKRTTEPMDFLHTGGPLGALHAKYLAAMEQDVPPIDAATPRELVESFQDVILAQFVMGRVRTSRSTSANLTTARRCIVSVCMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXY7</accession>
    <name>A8PXY7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731371.1">
        <property type="nucleotide sequence ID" value="XM_001731319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXY7"/>
    <dbReference type="FunCoup" id="A8PXY7">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXY7"/>
    <dbReference type="GeneID" id="5855678"/>
    <dbReference type="KEGG" id="mgl:MGL_1554"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1554"/>
    <dbReference type="InParanoid" id="A8PXY7"/>
    <dbReference type="OMA" id="PYEEWSD"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="251" mass="27277" checksum="CC9B3F873D330CF5" modified="2008-01-15" version="1">MAERGRGGFGRDRGRGGRGRRGARKDEKEEWVPVTSLGRLVKDGKIKSMEEIYLFSLPIKEYQVVDILLPKLTDEVMKITPVQKQTRAGQRTRFKAFVAIGDSDGHLGLGVKCAKEVASAIRGAMIMAKISIIPVRRGYWGSALGKPHTVPAKVSGKSASVMCRLVPAPRGIGIVAAPAPKRLLQLAGIDDVYTQSKGQTATMGNFLKATFEAVAKTYAILTPNLWEEVPVPPTPYVEHATHLARAGKKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY07</accession>
    <name>A8PY07_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731383.1">
        <property type="nucleotide sequence ID" value="XM_001731331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY07"/>
    <dbReference type="STRING" id="425265.A8PY07"/>
    <dbReference type="GeneID" id="5855690"/>
    <dbReference type="KEGG" id="mgl:MGL_1566"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1566"/>
    <dbReference type="InParanoid" id="A8PY07"/>
    <dbReference type="OMA" id="CYERCKW"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="8">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="667"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="778"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="915"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1001"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1081"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="667"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="814"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="841"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="867"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1001"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1037"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1128" mass="121046" checksum="5A970B81450EC328" modified="2008-01-15" version="1">MRIEELKQEGHWSFRQPKRIKGPVERKTHWDYLLEEMRWMQTDYREERKWKLAVAYELAHQIAQWHRSTPEERIAMCASRRMYKDLQEPMDVDKSCYPSIHKEACPDVDRQASSHGAYEKREREEYGPQSTGHAVETKSQRHADVNVDVRGPDAHAEGPKMATMREQPSQGEPHGALSAQETPAVHHAGAPQHINKPPSAKGKNAVSDADADADAETDADGEADGEADGKAHRDKDMHARSMPSITYPESDMPPTSETPALRSQADKEVTLVDKLPLALVTAIRAPIFSLDRTTTSVSPWSLLETLDPQTSAALTQMEQAPTLRAEELDFAKLFPELPQYSPPHASDDPASQKRRDDSHAPPSRLVHVTRLLDSRPVLVSTLDPANYHEHGLWVNASEWAERLPSVPEGLGPGAVPPHFGIQAPGSLLFARRSGKVSREHTMLALHAGGPPAPPARPETRIEQLSWSADDDAFVQALAKQYRDHWALVADVFNSARLVLPTEKRTAWDCYERCKWLADEQRAQRPPPKDTKKQHRQNLLDTMRKWAKRREQLQRQAAATAAANAQTKRASLAAHDTHTQIKMSATPTPQALSMLKTERDQAAIRQFFEQQRAAQFALAQQQQQQRMQIVQAQAQAQAQAQAQAQAHVQAHAQVQAQAQVQAQAQAQVQAHTHTQTSSSDDQQQRPATSVLSSATSPTPPAARSPVPATPSTAHASVPRPSVTQMPSTPSPVQTQQYLAALTANQNAAKQHPIMVAGQSMPFARTGQPVFGIDTSSAFGNSSSTSSIKNATSQVQAPSAAPGTNAPRPPQPIVIASSSPSSQTARLNRSSSAAIDARPLGFPGSATPTGTASTSAPGSVPGSVPAHDASSGSGTGAASTPTGITGATGTAGHGMPATPLTPNRTAIAMNGAHVQGRPTTFTASMPSRATPSPATGMSPVGPAPAPATAPPNLHALQQQLAITLAASHLSQEQINGLAIQLYKQAQHQQQQAQQQAQQQAQQQAQQQAQQQAQQQAHPHPQQTPPTAHPHPSYQPQVLAQRQGATQQQGAQPQRAGYEAQGAGSFAGTNTSRYVTMPQATASMGSLNVTPASPIVPSGQGGQGAQSSQSSQGAQGGHGANSHQGTPSPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYG4</accession>
    <name>A8PYG4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protection of telomeres protein 1 ssDNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1657</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731474.1">
        <property type="nucleotide sequence ID" value="XM_001731422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYG4"/>
    <dbReference type="GeneID" id="5855781"/>
    <dbReference type="KEGG" id="mgl:MGL_1657"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1657"/>
    <dbReference type="InParanoid" id="A8PYG4"/>
    <dbReference type="OMA" id="HAYLHSS"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Protection of telomeres protein 1 ssDNA-binding" evidence="9">
        <location>
            <begin position="428"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="583"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="649" mass="70180" checksum="16F1914D56A46C80" modified="2008-01-15" version="1">MGRSRRGRGSAASNGLDQLRASFPYPVHDDTPGPPFPSTGDQHAHADTPLLSVGPSETGMLGTYASVSLWMSRIARGRGAIVCTDGILSDLSEMRGSVSTPSFRCVLDSAEHISIPLTFHGPHAAALHQILRNHAPGVRVFVSGYGAEVVRATQSPPRAGLIFAERMALKALLERHDGNTLTLWFEGDRGRPATLVMQPVSMTNSVAHGMRDAPIEDVARDNRSRVRSDIPPSSLSHEIASSVNDRASPLSSDPAPVLVQTKVMDLARPGTLDGVVYTPLSDVQIGTTANVIGVVIDKPIVHQPKGRVDGTMSDAMLRVAMQPPKSWDTGTTLLAANLFARTVDQLPTHLLRGDAFLLRNLQIQMYHGKAHGVGPAFVPYSWASCRSPQEWNLSPGAHLGVEERTALAQIVHHATPTSTKSSHPLVSLDALQSNSYVDMVVEIVRVSIKGRVPDLYVTDYLPNRQFYGHDTLLAHHHKLPKATYGHLVFQIGLWGEKASSLSFRLRPGQLVRINNVRVKTNSLGTLHGSLGNSLDDKAHVEELDHRDPLAQCILQRRSAWLQQQQPRNHTYYPQEIVSADAKPWTSSPAASSSSSSPAPVSKKKRLSSVSSSPTSSLPPASLLPASPPEPVSAPRFDLDSDDSESCLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYG6</accession>
    <name>A8PYG6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731475.1">
        <property type="nucleotide sequence ID" value="XM_001731423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYG6"/>
    <dbReference type="STRING" id="425265.A8PYG6"/>
    <dbReference type="GeneID" id="5855782"/>
    <dbReference type="KEGG" id="mgl:MGL_1658"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1658"/>
    <dbReference type="InParanoid" id="A8PYG6"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="319" mass="35953" checksum="7610CCCA949263F5" modified="2008-01-15" version="1">MPTRRVDMEPLPPRRTRSAARLQAAIEALDTPVDDEDESEGEEDDGEEDDSLVGRRRRRRSKRAEAMAAKKQRTAVVERAQRILGPPSPVKPLVDDAPRMSLEAKVACLVELCDALSMSRAPHESPLHRLVQPVVEQASEDERAAKQHVQDINDQCDAEMRAHKKQAPSMASTQYGVWKARMHQLTHTHDCARFEARTRHYFAQRRACGRSGPLGRDDEGREYWHVLPACDPSDMEAPGAERGVHAPFSGHWSHVLLVREAANSDRWYATTSADQVAAILAYLGRRRRTDETLHMHLAGVQDYLAWLDLCQAGASRHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8PYV8</accession>
    <name>A8PYV8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731549.1">
        <property type="nucleotide sequence ID" value="XM_001731497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PYV8"/>
    <dbReference type="GeneID" id="5855856"/>
    <dbReference type="KEGG" id="mgl:MGL_1732"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1732"/>
    <dbReference type="InParanoid" id="A8PYV8"/>
    <dbReference type="OrthoDB" id="3349465at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727147" evidence="1">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="207" mass="22542" checksum="6DBD810533879E0C" modified="2008-01-15" version="1">MKLTFSAIIAVCIALAEAVPSAKRDMECKSTGRSGRLIGHNSATGAKSIFEFDSTDNLSTLHEVLKTDQEFEFYSCKAPSNEFAGAGFGAAYGQIRSKKDSDMCVTSGSIVIGGKEKGEPEFLFINNGRVTLEKCAKDGMTLRRQWFAASQGVPMCPPTVSLLGYQSDVPQNFIGINKDGTAHLEANLYKNMDEYFYLARDVSDSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZR6</accession>
    <name>A8PZR6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730944.1">
        <property type="nucleotide sequence ID" value="XM_001730892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZR6"/>
    <dbReference type="FunCoup" id="A8PZR6">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZR6"/>
    <dbReference type="GeneID" id="5855251"/>
    <dbReference type="KEGG" id="mgl:MGL_1943"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1943"/>
    <dbReference type="InParanoid" id="A8PZR6"/>
    <dbReference type="OMA" id="WANNARK"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="15"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP43730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="477" mass="53449" checksum="23AF358D74910177" modified="2008-01-15" version="1">MSVKLNDGSRQINQYHILKCLGRGMFATVHLGEFVDEDGQHQYVAIKEFDKRRLCRKRHMDMRVQMRGNLRAMNDKDPLYLVRTEVAILKKLCHPHVVRLYEALDDPDEDKLFLVFENCPGGPLYHIEPGKQSECIPEDKARIYFRQILSGLDYIHANGIVHRDIKPENILLVDDNQCKITDFGVSEMVLEPGDNRVKRSVGTPAFMSPELCRMGSKQSSHGCPDDVWALGVTLYTIVIGHLPFDRENLLDLYDAIQYDQPDLKGAPSAECRDLLLHMLDKSESTRITVKEIYNHPWVTQHGKEPMPLPAATVHANSELPEVTEEDLCCAVFRISSMFTVARAVSKFKRAGSRRDSRSTSASDDCDDHGQNPPKMRPKSVPGFGSSDIDNWDAIYEQSASFPTKSRQVQSPVQEIAMAMSPTTTMDRATTEPFCESLPQNDASPGIPLSASPDNASDPVICVSSPTEVDKIVSPFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0L7</accession>
    <name>A8Q0L7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731052.1">
        <property type="nucleotide sequence ID" value="XM_001731000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0L7"/>
    <dbReference type="FunCoup" id="A8Q0L7">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0L7"/>
    <dbReference type="GeneID" id="5855359"/>
    <dbReference type="KEGG" id="mgl:MGL_2051"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2051"/>
    <dbReference type="InParanoid" id="A8Q0L7"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="195" mass="21380" checksum="5D70A2191BA1A340" modified="2008-01-15" version="1">MPSAWSATYTLSTPVPGTGHSQNESVRRASATQTLSVPDVLDRPRDKTRGAEVSHSALQFLFAEMVIYAQGRVSGISEFEQLLGSMGRQVGLRALAMQTQRAQSASNPKRPQRETRLLKTLLWVHSTLWKAVFGVQADNLERSTESDRSDEYMITTNVPLFSRGISVPKEMTQLSVEAYAAGIVEGALDGLGFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0M6</accession>
    <name>A8Q0M6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731056.1">
        <property type="nucleotide sequence ID" value="XM_001731004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0M6"/>
    <dbReference type="STRING" id="425265.A8Q0M6"/>
    <dbReference type="GeneID" id="5855363"/>
    <dbReference type="KEGG" id="mgl:MGL_2055"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2055"/>
    <dbReference type="InParanoid" id="A8Q0M6"/>
    <dbReference type="OMA" id="ATHRCIG"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="471" mass="53669" checksum="67D249EE31A24A6B" modified="2008-01-15" version="1">MDAAYATHRCIGALHAIHARHVCCVDAQPCFVALRRQHEIPFYVTSIVPGPHAMWGECTGAPIHAEFDFAPWMRKDGGLAARVVLVSLWVQICGEWHCHWERVLNLLDTMPVGADMAALSSCPPNQPSVYVCLRRNDTQYEYFAVEHKNTNSPVPLKTHTLTTHAPARSCTWSDLEHLVHDCSEISRLCEANDLLEMRCAPALIDMSTLARKRYQYELHDTLDQLRHTSEERKHDLRRCTYCSELFARVRIRLRRSVRRDLEERQYALQERRDRLQQGRMKLESINNTCTQLCTESNHVSTELRAVQVRLSNERARLLRELDLIYPIDLVNARDLLYSLVGMPLPNGIATTKANASALVHKTDMVEASTVLSYVAQIALLLSKYLHTPLPYPLTSVGSRATIQDRISVMSGPRSFLLSGQYNELYRYEYAVFLLNKDLEHLMNKYGVPVLDLRNTLPNLKNLLVTLSAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0W2</accession>
    <name>A8Q0W2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_2090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731091.1">
        <property type="nucleotide sequence ID" value="XM_001731039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0W2"/>
    <dbReference type="FunCoup" id="A8Q0W2">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q0W2"/>
    <dbReference type="GeneID" id="5855398"/>
    <dbReference type="KEGG" id="mgl:MGL_2090"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2090"/>
    <dbReference type="InParanoid" id="A8Q0W2"/>
    <dbReference type="OMA" id="FAGIHFT"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="63"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="547" mass="60624" checksum="66CA074163D57084" modified="2008-01-15" version="1">MLTVPTFGDYKLPNIDNEPMRNYESNSKDRAELQKTVDELLASEPFEVPIIIDGQEFKSGKLSKQVNPGNHSQILCHYHEADERMVRVAIEGAMKSKEMWANLPWSERAAISMKAADLIANKYRYKLLAATMVGQGKNVWQAEIDAGAEICDFLRFGVKYVDDMYQIQPPRNSPGVWNRTEYRPIEGFVLAISPFNFTAIAGNLVMTPALVGNVVVWKPSPMAIYSNYLVYKILEEAGVPPGVIQFVPGPAQEVATAAITHREFSSLHFTGSTFVFKSLWKQISSNLDTYRSYPRIVGETGGKNFHFVHKSANVDVVVTQAIRAAYEYQGQKCSALSRLYVPKSMWEGGLKEKLIERTSSLSMGPVQDFKNFMGPVIAKHSFDKIMGLIEDAKKEGGKVLVGGHGDDSKGYYVEPTIIETQDPRSVTMVKEIFGPVITVFAYPDDDIEGACALVDTTTEYALTGSIFASDRLALVHISNLLRNASGMMYYNDKCTGAVVGQQPFGGARASGTNDKAGSMNIFFRFVSPRTIKESMLDPATHLYPSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0X2</accession>
    <name>A8Q0X2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_2094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731095.1">
        <property type="nucleotide sequence ID" value="XM_001731043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0X2"/>
    <dbReference type="STRING" id="425265.A8Q0X2"/>
    <dbReference type="GeneID" id="5855402"/>
    <dbReference type="KEGG" id="mgl:MGL_2094"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2094"/>
    <dbReference type="InParanoid" id="A8Q0X2"/>
    <dbReference type="OMA" id="RAIVVWP"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="509" mass="57464" checksum="4685BF0384F37287" modified="2008-01-15" version="1">MDQYADQSKQASLNHDPEALLSVINSVLGTPNINDTNAGTWAQESLGMLNPNADDGSLTQVPWFNNRDFPLNPTPNVNSEQVDGQPAWTGLPPELNVEIDNGLQPKGTHIFTLDTSMNVTDKRTADNQPIVQPFYVSHPDMYDKDKVDRVIITLPGKPRDSWKYINIHYNVLMWYCNQNKVRWNQTVLASPAFLNQDDVQAGGAQSNWLAYKKSGWALGGTSHHPTMQHGVSSFRVLDLMTEHFIDMFPSLKNIVFTGHSMGAQTVIRYAVAKNKKWYDSHVSYWVGNPGSYAWVVKDRPIHDPTNLNGESCEDTISNWPYGLDGKLPAYMHEKDKNNTAGVVDRFRSRRVRLALGLLDNGAGSTQCPAQYQGYNHLERGSLFSKALIQMPDGYPQNHSLTYISGVSHQDYEMIAADQSGDFIFADPFDGRLVSSSRPVHHRRPPHHGPRTSSKRDWDGSTYRIIAWIILAAFFVAIVAGLTCFNMLFKANANDWDRDYWEYDSKRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q181</accession>
    <name>A8Q181_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730749.1">
        <property type="nucleotide sequence ID" value="XM_001730697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q181"/>
    <dbReference type="GeneID" id="5855056"/>
    <dbReference type="KEGG" id="mgl:MGL_1748"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1748"/>
    <dbReference type="InParanoid" id="A8Q181"/>
    <dbReference type="OMA" id="HIEISHC"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="48531" checksum="2858E747F6BF4F33" modified="2008-01-15" version="1">MDVRLVVSSQAAKTVKLKSITIGVRQTVTFFPEKGASSQPIHQKSEMLATKTKRLGKKIMQGEFFLQDLSLVIPKNHAIMSIHTAKHIEISHCLRVDINLEKSTLTFDRIDVLISGFLPSASSSLITRIGDVPSLDATQESNPHSAREHTSVFVPEGESILPSHVPLEDPDPAIYTDDAVPMPDIESSDFAALGTATPHRPVSFTSSPVTPTSAWRASTTIDPSISMRPGDILPMVSAGPTDPSLLRNSARMSQMNSLPTPNPAATSTPSPIARVKPPQAAVSSGSFRTAEQEKVQLFERARAEAEQYQSEMGEDVTFPRENRPMGDYSMHNVNSSNPNNIFAAHASVPSHAEEGRRLRINPEAPSHPDEDKVSSPYITKSEAQAMEEKSKLQSHYAQLDARQVEPVSSYEPTPAPSYMAPPGVPRSQPSEPGSSGYPPRPPKVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1B9</accession>
    <name>A8Q1B9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730765.1">
        <property type="nucleotide sequence ID" value="XM_001730713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1B9"/>
    <dbReference type="GeneID" id="5855072"/>
    <dbReference type="KEGG" id="mgl:MGL_1764"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1764"/>
    <dbReference type="InParanoid" id="A8Q1B9"/>
    <dbReference type="OMA" id="VEWIVIF"/>
    <dbReference type="OrthoDB" id="2538408at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="247" mass="27029" checksum="EB612669A205A36F" modified="2008-01-15" version="1">MGELCVAKAIPPPGSRRLGGPPVPVSANRSVFCEASRNLKWTITNTGINAPVYKLTLPNPDMPGNDQPLFQISKPNPNDTWWTMFYFTYGGHMIPPKRIEFGRIQKNATASNGGGAGTRVTITGRTPEQQAVWQTLGEGNEDMVEWIVIFAALNLIDEEIVRAASRASEPRAQQMQPVRQPSQQPRSPAMPATAQPQNRMPSAQREPRAQQGPDLFASAGTRAHPVPGNMSASKGKARGKRMFPFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1K5</accession>
    <name>A8Q1K5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_1802</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730803.1">
        <property type="nucleotide sequence ID" value="XM_001730751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1K5"/>
    <dbReference type="GeneID" id="5855110"/>
    <dbReference type="KEGG" id="mgl:MGL_1802"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1802"/>
    <dbReference type="InParanoid" id="A8Q1K5"/>
    <dbReference type="OMA" id="PGHEHFA"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="12"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="219" mass="24636" checksum="BDED168B25836C82" modified="2008-01-15" version="1">MSHPGSLLWQNNGPGAVLAQVAVSSFVLCVIGTGIYKVWDGSFSFFAWHPILVTLGLFCLIQSILVVQPTKTPAEKQAGLNWHKTIVLYLGLPLITLGAWVVWYLHDLPGQKHFISWHGMLGCAIIVLIWTQAAFGATTVYWKSYFYGTESRAKAMWKYHRMFGYTLCSLLMAELLLAFWEVKWMYRTGGFVLVVLSTVTMLLTAYGVATRVQTSKWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q294</accession>
    <name>A8Q294_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000007">
        <property type="protein sequence ID" value="EDP43504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730718.1">
        <property type="nucleotide sequence ID" value="XM_001730666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q294"/>
    <dbReference type="STRING" id="425265.A8Q294"/>
    <dbReference type="GeneID" id="5855024"/>
    <dbReference type="KEGG" id="mgl:MGL_2172"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2172"/>
    <dbReference type="InParanoid" id="A8Q294"/>
    <dbReference type="OMA" id="ARFHEIN"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="341" mass="38894" checksum="841523E54BECFAB2" modified="2008-01-15" version="1">MDRHLHAVPLDAFELLGIETHATEAQIRTAYRKRSLQLHPDKVKDVPPDQAAERFHQLTLAYEELMNPASRAKLQESLQREREKLKRQAAFDVKRRTMTADLERREEQDRLQRMERERQRLARQQRILALREEGRAMRIDKHERLLEAWQQRTSRLNPVSTQALTSTPDSSSTLTELPPWDANDSWVLVRFPTEQAHEMWGSTAAPEPLTSSPLCLALASSYGPLASASVKPSHKQRREISVVVQFLHGVHAWRAVSEGSDLRCSHVLLQDCWIRWCDASGKATSLPPQRVQACLARGITAQDMSVQLSTALTDCGDHFDHDYEARTLKRLRQAAAMHVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2U3</accession>
    <name>A8Q2U3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_2236</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730440.1">
        <property type="nucleotide sequence ID" value="XM_001730388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2U3"/>
    <dbReference type="FunCoup" id="A8Q2U3">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2U3"/>
    <dbReference type="GeneID" id="5854747"/>
    <dbReference type="KEGG" id="mgl:MGL_2236"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2236"/>
    <dbReference type="InParanoid" id="A8Q2U3"/>
    <dbReference type="OMA" id="NANCDAV"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="17">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="16">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP43226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="281" mass="31386" checksum="31794E71BC12EC41" modified="2008-01-15" version="1">MNDALLDEVSDPSDWTGAWSELRPLDTSLRCGLCYKKAFDAELVAQPALEAAANHWRHARRLRPRKRAAVDDLDGEHVDYRALDASTLVQCPICQHEFDAATLNEHLDRGCGLDDPHPASSSALSSTASSKMDSWLRRPSMTHQPSPKRLTRPQYQLKSEKDLRKMLEALELPASGTKDRLIDRHRHWVNLYNANLDAAPALRASIPSLRKQLRQWERAQDESLCSKTITTEKQAQSWLKANQDTYASLAAQARATLHASETKYSADPSTGGQDSNIPGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2U8</accession>
    <name>A8Q2U8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_2238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730442.1">
        <property type="nucleotide sequence ID" value="XM_001730390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2U8"/>
    <dbReference type="FunCoup" id="A8Q2U8">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q2U8"/>
    <dbReference type="GeneID" id="5854749"/>
    <dbReference type="KEGG" id="mgl:MGL_2238"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2238"/>
    <dbReference type="InParanoid" id="A8Q2U8"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="273" mass="30945" checksum="B4301921E9ABA79F" modified="2008-01-15" version="1">MVKPRTSTSKPRRTFIGVAILATIIALIGTIITYVEANLRQFFIFDQPKLEAIAKNAVAKHGDAADMIFEEIVGELQKDPKIAPMLNRNSFRDPNEWVFNNAGGAMGSMYIIHASITEYLIFFGTPIGTEGHTGRHTADDYFHILYGEQLAFRAGDLSAERYPAGSMHHLKRGEVKQYMMPESGCWALELAQGWVPPMLPFGMADSLFSTLDLRTFGRTCVITAREMILNLLRGMYFSQIYRVVSDSILQASFERRYDYPYTACRLFSRIRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q2Z2</accession>
    <name>A8Q2Z2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730478.1">
        <property type="nucleotide sequence ID" value="XM_001730426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q2Z2"/>
    <dbReference type="STRING" id="425265.A8Q2Z2"/>
    <dbReference type="GeneID" id="5854785"/>
    <dbReference type="KEGG" id="mgl:MGL_2274"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2274"/>
    <dbReference type="InParanoid" id="A8Q2Z2"/>
    <dbReference type="OMA" id="ARSHICK"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16492">
        <property type="entry name" value="RING-CH-C4HC3_NFX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44223" checksum="E4878B3F37C2D611" modified="2008-01-15" version="1">MSDMPPAAASLATSQHPREGERDKLRGARKEKGTMQEDHVEQGQEKKGGDVKGQGSRAGRSQGQVREQGRGRARGQWHGPGRGGAQTPGNSRGRRRGRGHTNANVQIDKPDDKGTMKEDPSDVLSAPKSDSPAKKQTATPKTAPKMRRFGAKLTNSSETPPAAMSGTSRPVSVPEYADLRSRILAELANDEYDCTICYNVIKRRQPIWSCTRCYAVLHLTCVRTWAERSVSQIQEQNAMHQDAAVRETPGHWRCPGCQDVKYEVPLVVSVDVYGTGALQSSATQGPVRPVLQRSKSLVSVARSHICKCAVHNCHERLRKEQKQTPYLIAHSIQISPTQVPLAFFPVDSCVGRAWPVAIIHAHSLATPVHARHAPLHFMKYHAFVAATHVRCGVVSDCLRRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q348</accession>
    <name>A8Q348_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730514.1">
        <property type="nucleotide sequence ID" value="XM_001730462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q348"/>
    <dbReference type="STRING" id="425265.A8Q348"/>
    <dbReference type="GeneID" id="5854821"/>
    <dbReference type="KEGG" id="mgl:MGL_2310"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2310"/>
    <dbReference type="InParanoid" id="A8Q348"/>
    <dbReference type="OMA" id="HTEDEQM"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="33825" checksum="58EE44D299627050" modified="2008-01-15" version="1">MVSVLHALSQSPNMSSTLEMDGHLWNKLGEYYDVNELNKQEENGDDENDTPLWMREYEGLQDMLRTNERARTRLVHGLDKEEFALQPFMSFEPWMEVRRVAPTGDHESQSDVPQSVVPPSSDDDLTDADSESKTDDREMRSSANHPPRRNRRKRAHTEDEQMPESQKDGAAAAAPVSAATGVSTRAGKRRRSTKMDDESADSYSRPITTRRQQRQIEERSAEDAAEAAASTSTTGATIGTTSTSAGGAHGGTASSSAGTTDEVAGSANTPRASRSTSSRRSSTASARSQANSAGSYASPTPSTRSSRPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q373</accession>
    <name>A8Q373_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_2326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730530.1">
        <property type="nucleotide sequence ID" value="XM_001730478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q373"/>
    <dbReference type="FunCoup" id="A8Q373">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q373"/>
    <dbReference type="GeneID" id="5854837"/>
    <dbReference type="KEGG" id="mgl:MGL_2326"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2326"/>
    <dbReference type="InParanoid" id="A8Q373"/>
    <dbReference type="OMA" id="FRIKHEQ"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="108"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP43316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="182" mass="21574" checksum="0B03DB44342339BE" modified="2008-01-15" version="1">MRQLKFHEQKLLKKHDFLQWKNEHNLREIQVMRRYHIQDRDDYQKYNVLVGKTRQLALRLSTLSASDPFRARHESMMLNKLYDMGLLDTGAKMSDIMERLNVSAFCRRRLPVVMVRLHMSESVSQAVKYVEQGHVRVGPDTITDPAFLVTRSMEDFVTWVDTSKIRRAIANYNDELDDFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3H0</accession>
    <name>A8Q3H0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730602.1">
        <property type="nucleotide sequence ID" value="XM_001730550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3H0"/>
    <dbReference type="STRING" id="425265.A8Q3H0"/>
    <dbReference type="GeneID" id="5854909"/>
    <dbReference type="KEGG" id="mgl:MGL_2398"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2398"/>
    <dbReference type="InParanoid" id="A8Q3H0"/>
    <dbReference type="OMA" id="TVPWFNF"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="157" mass="17333" checksum="A9EE99896A5CAFFC" modified="2008-01-15" version="1">MPQKEFETEFPLIDSDPHFRRVVRYFRPSDYYAIAGTAVAFPSALWLLESSDPARGRGKLGAALKLSTFLGLCGGFLYAYQRSTFRFWGWTENAREQELAKAEVASGDVPGQGKSSLTDELQGVAHRNSAFSQLNLGTSVLFRVGAFCSAPCCLYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q3I3</accession>
    <name>A8Q3I3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2411</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000008">
        <property type="protein sequence ID" value="EDP43401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730615.1">
        <property type="nucleotide sequence ID" value="XM_001730563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q3I3"/>
    <dbReference type="FunCoup" id="A8Q3I3">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q3I3"/>
    <dbReference type="GeneID" id="5854922"/>
    <dbReference type="KEGG" id="mgl:MGL_2411"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2411"/>
    <dbReference type="InParanoid" id="A8Q3I3"/>
    <dbReference type="OMA" id="INHWSSH"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="422"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="943" mass="105795" checksum="3CF1B818E9EBC059" modified="2008-01-15" version="1">MYDGVVSKDNVSGSDVNTCMIASMSGDSAALPVLLAQSEQNPPPKTILKDPNPHLHGADHEWTERPGDLMRFTLYKSREYYYCVYTSSDQKRYRILRIHRIPPFLSQEKDERLAQNSELTPPVSSKPHEQPGPQSTESPPTQPKSSTRPTRHKRGKSLSSVVLSIADGPDDVLPKPATTPSGTLSSEITELASSLVPEHATSVPGGPESAGGKYLGLYDADVLQLRLTSEWKHYIGATADSPARDAQSATPERTVRPISDLGSQRSPKRSQPRTTNQPLSGASSNVQPSVSESADSPSKLDPSMDPTQEAAWALQVSAYSTEHTPPNVMHELLSTIFDGTSESTRCKEVGRYFGIVGFVRFTAGYYMVLISKRSVVSLIGGHYIYHCDETQVLPVCHSHVLNSVSGRPMSRDARESQLLRSFSQVDLSKNFYFSYTYDLTRTLQENMTGPRAQAQLFSTKAWGYKDKFMWNYRLLEPAFGECRDVDLNTYVHPSIHAKRQWIVPLVHGFADQAKLNVLGTAIYVSLIARRSRHFAGARFYKRGINSDGHVANDVETEQIVNKPVTSPFFAPPSRYDTSASLRASPHFASYVVMRGSIPVFWTQDSTNMSPRPPIEISVVDPYFTAASRHFHDLFSAYGTPVIVLNLIKSKERQPRESKLLKVYTECIEQLNQFLPVDQNGQDHRIRHIAWDMSRASKSRHENVIAFLEQLAEETLQATDFFHSGPLPETFRRMEHPKNEPILLQQGIVRVNCVDCLDRTNAAQFVLGKAAFAYQLHALGLLKRPELSFDSDAINMLTEMYHDLGDTIALQYGGSALAHTTDTYRKINHWSSHSRDMLEGIRRYYANSFADADKQASIDLFLGQQSSDSAVSLPLNTASSDHALSLTSFLDTEEQMDTKLAYLRHFVNTDKGFWDGYYRPTLFTEYVLFDFNFIKFLSLSDMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4M3</accession>
    <name>A8Q4M3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730192.1">
        <property type="nucleotide sequence ID" value="XM_001730140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4M3"/>
    <dbReference type="GeneID" id="5854499"/>
    <dbReference type="KEGG" id="mgl:MGL_2574"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2574"/>
    <dbReference type="InParanoid" id="A8Q4M3"/>
    <dbReference type="OrthoDB" id="3356136at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="555" mass="60174" checksum="6CF200643B2DADB8" modified="2008-01-15" version="1">MTAEVPDPQGLGDAPLSSVSDDSMTHPSFDTSASLLQQDQQEQQMQHSNEPSDAASHMSASLPLTPQTQRTSDKQGELGERGASSSPPSFALSTHSAPTPRRGRRVRYVRSREPPNTPPAPLTSAYSSRLQREQVDRIVAMCHDVSMGRIKRMAPVHAETTRAIATKERVCMELREELAREEAQLEELRSAWKRMTQRIGSHAPSPRLPPQLRHSTPSQTQSRRRSMAHSPSHQPSPASGTPTRSHMPPAHEAMRESSGPSTDHPPSRTTSVSAPQAEASLLASSSASGPDTSFKSSDSAWSDLRRIPTHLSNQLHAVMDQLSLTADEDTSLGSSPSHDRTQRAGANLKPDTTAGAAEAAASPRMSLSSLPQSLDELSSDMLRDKLSSGWHVLSQRLRDTTASLKDMSAWIPEDMPPLTSRSSRASLPVSMDENAFSGLTSNLESMSMSPLKSDPRRASTMTTIPPVTSPRQNIIPLPSETQRNLAAQHKASLARLSSTTSSPQRSARSSHEKSLPSLPPEGQSEQAPQVMYGHAYDSDLGLQNIPQNQPPHPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4M7</accession>
    <name>A8Q4M7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Timeless N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP42982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730196.1">
        <property type="nucleotide sequence ID" value="XM_001730144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4M7"/>
    <dbReference type="FunCoup" id="A8Q4M7">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4M7"/>
    <dbReference type="GeneID" id="5854503"/>
    <dbReference type="KEGG" id="mgl:MGL_2578"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2578"/>
    <dbReference type="InParanoid" id="A8Q4M7"/>
    <dbReference type="OMA" id="MHRIAIK"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="6">
        <location>
            <begin position="91"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="913"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1027"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="975"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1050" mass="116534" checksum="B2564D0E9FAC4D78" modified="2008-01-15" version="1">MSRVASEVDAWDDDQFAEDELAESVGTSSGTEAGVDTDADADAASADEGHDNESVDDVDERVALLRAPILSICSALGGYEHMMRQGRTEIVYRIGDDCLECLRDLRRLWRQDDTDASRAIARVLADLGTLHNDLIPILLHCAGADASEKEQKIALACTDLMTALTWPIDWSAELHDIATREEDEHVLSKLLELQGAQVQYKASILRVRAKEPRLSDRTVLSCVLRHVLVPSLKPRTERTDRDIGVVSMCLHFFRNLLTIRDPPLHTTKSSTNIANTALHSVLVQQMESAHILATLRMLASQADSKDYDLWTPVVADCVYQMYAGSIPSQLSNAGGANAQASNYAGARGPAHLLAHSLASEARTKRASLRGASARHSRFGTSIQFRAHDGTLRMAHSPAALTDSVAHLEQRVMDRTKRRVSRQRPATERGAPPRRVLWTPGAAAVLCRWADQFVQDGLLDVLVRAYLRDIHAERERVGDLDMARCKAMYIASFFIDYALARHMRLELVSAWLEPWSFRLVRARTAVALENRQWLEFTVSLRLWTVLLKLVDALSRGSPTEQEAADSLQHTLYYDGDLLDTALHAMHAYSAQSFACLEAVVDFAYMMPRLLERHAAKSAYMFVKQRRRRQPGQHDTDDQTDVPPDADTNVRSERVFRFESFERAMASASLVHACTQYLARYRDSEHAHVMLPKLASVVYRIIVRVSRVALFFSAKVRRVWAHAMRDSFALRQAHERAASDLTRLYHIIHKSFTRLSEASRAAYNADRRPPKPALEMFVRSDLSHSEQIGVAVGLLAEAHKLTCVSWVRAALERASAERMAMGDMDPMHPPPALQAQFPVHELPDGGGHDAVHCAPLRLLCRLVGLKSEARGSDATVWYVPTDCVPGALTRCARVIDQYLAEPFVLEGHALSDLVRMKRPTQGSRTSDHARKKARQESRASPLQADASESDNGSDGHERFVFSTNAEHSERDVPGLSDTYTASQTASSSPLADHAPEASTDRGVTDATRATGHLAPTPALVLQEGLYHKEAPISARPIRTGSPGLFFSDSDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Q7</accession>
    <name>A8Q4Q7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">60S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_2608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730226.1">
        <property type="nucleotide sequence ID" value="XM_001730174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Q7"/>
    <dbReference type="FunCoup" id="A8Q4Q7">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4Q7"/>
    <dbReference type="GeneID" id="5854531"/>
    <dbReference type="KEGG" id="mgl:MGL_2608"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2608"/>
    <dbReference type="InParanoid" id="A8Q4Q7"/>
    <dbReference type="OMA" id="NPMKELK"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="81"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21509" checksum="3F18746718475219" modified="2008-01-15" version="1">MLWTATGYVLSDNCLNKLHLNACMSACELKVDKLVINISVGESGDRLTRATKVLEQLTGQTPVTTKARYTLRGFGIRRNEKIACHVTVRGAKAEEILERGLKVKEYELQKRNFSDTGNFGFGITEHIDLGIKYDPGIGIFGMDFYVCMTRPGVRVSRRKNRQSRVGAPHRVRKEETAAWFKQRFDGIILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4U6</accession>
    <name>A8Q4U6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730260.1">
        <property type="nucleotide sequence ID" value="XM_001730208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4U6"/>
    <dbReference type="STRING" id="425265.A8Q4U6"/>
    <dbReference type="GeneID" id="5854565"/>
    <dbReference type="KEGG" id="mgl:MGL_2642"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2642"/>
    <dbReference type="InParanoid" id="A8Q4U6"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="94" mass="10295" checksum="797946FE9E3A32B8" modified="2008-01-15" version="1">MSKGEARAALKRGAKMARAAARQQAAAEAKEKARLERMTDSQRAAATAEADAKAREDAKPKSLAEAEEKELAQRRALRKQRRDSIKSSNFVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q4Z3</accession>
    <name>A8Q4Z3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase I subunit RPA49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730297.1">
        <property type="nucleotide sequence ID" value="XM_001730245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q4Z3"/>
    <dbReference type="FunCoup" id="A8Q4Z3">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q4Z3"/>
    <dbReference type="GeneID" id="5854602"/>
    <dbReference type="KEGG" id="mgl:MGL_2679"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2679"/>
    <dbReference type="InParanoid" id="A8Q4Z3"/>
    <dbReference type="OMA" id="FPAWIWS"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP43083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43238" checksum="23F58AA1BC83088E" modified="2008-01-15" version="1">MHEVSLSDFMPDKHANFQLYRAPSDAIEPSESASGSTSTSVPLATLDDRLLLAGDTNAIQYTSTNWGWGASARAAPELRRETRGYSGDYLMGIYDKTKKQVTLRAVPLFTLNRSIKALANLSSAATERGMHNDFDYTRARRDLGEAFGNKKQKQAARNMDRMKVNTENMDNILEHVASGIGESASTLPTEKELTASLNTSRALPQAHLDATEPAGVYPLESLVPMTVLNALHTRHLLKCTTQAELGKALRVLPQPSPWLLPRLWQIVQTAQNDAGNTSRAMELIRIGYYVAILLAFRKYARGLSRHGEDGVSSISQKMRLPDHERDIVMEHLVSHFAEQSRGSQRYAMTATGDTRLFASILVVGLHLEDFSIAPEAPAQELSVTTQRFVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q531</accession>
    <name>A8Q531_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730327.1">
        <property type="nucleotide sequence ID" value="XM_001730275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q531"/>
    <dbReference type="STRING" id="425265.A8Q531"/>
    <dbReference type="GeneID" id="5854632"/>
    <dbReference type="KEGG" id="mgl:MGL_2709"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2709"/>
    <dbReference type="InParanoid" id="A8Q531"/>
    <dbReference type="OMA" id="HATECSG"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="816" mass="87563" checksum="FF008A62A5E633E5" modified="2008-01-15" version="1">MQKCYPMLTPSAPAPLSEPELSTDESVTSEEGDADDRQRADRTSCLNEFSILTKHHTDSTVPTAQFFQKLADDVEQCWLHSSYSSIGCNPTRWKRGSDDIHEEEDETVQGSESRSTGTPISTTGTVTPNVIRSRANSTTQSPRTQALGPKVTEALVPPKSQDLLTHNCVTALRPDAMKSAMLFEEGAAATNSALPVSSFPNPQMLSVPAATSSVSSSPLVSDVSASGSTSKSTSPRPPGAASSVALAGARNAGIQAPPAPSVASGIPSRMRRQQRIQKSTENLPALRATKSYLTRTNAANVTPGHVFDGKPKQDKAKKKQSKILFTIGGDSEEDELPTEGDNEDDWSSEDDEANGGDAGKDTNTHESARLETERARRELDEECERMEMFKKRPIRSASLADLPHASNAMAPPTELGPTRGLLSTMLKPSEVSKQYPHRPRAGQTLHLSPMPNRAHCTRTHASARNPSTPTHLPRAPSFQTIRCNPTSGADKNDVINRSKSALALPLLNLTSLRSSTSSGRIVSPSPKHAVGATSPEPGRAVSNHGSESDESSAPPRTRSNLALSRLSAIAQRETSSTITTPTTLSSDTGDGRRLSSLVRSCNSIGNLMTATKPDSAHTAVHSIPSPASQHAPAEGEEDGLCLGVEADERAPLRVQRVLEATPQTTDVPQLSQACLMSDTMTESPVPQHATECSGTMPPLVDTVCEKEQSQPTEALVPTPCVHTDALSDPLHRRISTPNPLSARATVARQNILDEELSQSVRENLQWERESRARLLGIGLMGTVSSQRPRRTTDSRVVGLDQSRPHTDEGSFHHKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q548</accession>
    <name>A8Q548_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000009">
        <property type="protein sequence ID" value="EDP43126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730340.1">
        <property type="nucleotide sequence ID" value="XM_001730288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q548"/>
    <dbReference type="STRING" id="425265.A8Q548"/>
    <dbReference type="GeneID" id="5854645"/>
    <dbReference type="KEGG" id="mgl:MGL_2722"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2722"/>
    <dbReference type="InParanoid" id="A8Q548"/>
    <dbReference type="OMA" id="NIGAWPR"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="83592" checksum="D7F5B957F5A3B03D" modified="2008-01-15" version="1">MDEDDKGWLDKRNEKAQDNLANALKEIASDAGRPDSAQIEALLIKDPSKYRFISEDEFETIMYVFERTTCDRHPLLELDLSKLPPLSELLPQFEPDSLCSTLALPELPVQPNDLSIITSNLTSKPHNYNKPSPTVNMSSQELKWSAENPFRHLFLLKPCAYAVYDWWKLRRQAREGRPIVPSLNSDESNENDPYVCFRRREVKSARKTRKTDTLQLEKLVRLESELGQAKSLFFMVAQRERLKEREISEAKECWAHAHELMTLKRRWSIIGPDKGHEDESLFFGIQPDPTAPIHSSAALQNTQLMKKKRKADEISSPSAVTSTTLKLRRPKSETESTSNAKAVSDNSALKSSSLMERTTAMQQYIDRECTLRQQVDAGVEDLTDTAFQPVVAPPALRAFRPIQSDNHDTHFWSNHPFARPGRQSCFRRRIGRGGRIFLDRRPIAVSPAPANIGAWPRQRQNGFPLATFGFDRSFDPMKRADATGRILGATDSFRYHTPLIHSARVAPMLLPTPDLSWDPLNSKDPRAPLTHNPDLQFKCLSKNGAYHVPQGTDDASVSSDSTDHTHMTDDTADGQSTQATDLDQDEEAMKEDKDGAYVARKRDLNVEEESVEEQMERAQKLAERWRYNEDGGRYAGLGLLGLGGMEGDEEAVLDDYDQRFIRYRMSLLDETNLLKLSTDWTYMRQALIAASSNAQSKPTIAVGTDNAKNANSAEAPTGRMSESMNAASPLSSDTKETSTKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5I6</accession>
    <name>A8Q5I6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_2782</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729796.1">
        <property type="nucleotide sequence ID" value="XM_001729744.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8Q5I6">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5I6"/>
    <dbReference type="GeneID" id="5854109"/>
    <dbReference type="KEGG" id="mgl:MGL_2782"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2782"/>
    <dbReference type="InParanoid" id="A8Q5I6"/>
    <dbReference type="OMA" id="KPCMGIV"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="39"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1400"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1424"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1400"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1424"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1435"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1480"/>
            <end position="1607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP42582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1607" mass="177193" checksum="578EBFA9ADCE98E5" modified="2008-01-15" version="1">MAQTEKRPLPASEVHTILKKISADDVNTLGLSDDFAQPDWMVLTVLPVPPPQVRPGVTEFGSGMGQDDLTYKLADIIKASSNLRRMEQEGAPAHILNDFADLLQYHTATYMDNDIAGLPQSLQSSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVITGDPNLELDQVGVPKSIARNLTYPERVTPYNRAYLSDLVRNGPNEYPGARYVIRDTGERIDLKYNRRGDIALQAGWIVERHLRDGDYVLFNRQPSLHKMSMMAHRVKLMDYSTFRLNLSVTPPYNADFDGDEMNLHVPQSEEARAELAQIAWVPRQIVSPQANKPVMGIVQDTLCGVRKFTLRDCLMDYDQVQNILMWLPGWDGIVPQPCILKPKPYWSGKQLLSLCIPKGINVFLGDAKAASNNFVKDDGVHIENGEIMYGVINKKVVGSTAGGLIHIIFRERGPVVCRDFFSGVQRVVNYWLLHNGFSIGIGDTVPDKATTVNINETIAKAKSDVMNLIQAARHDWLKADPGMTLRESFEANVNRILNKARDDVGSHAEQNLPDWNNVKQMVIAGSKGSFINISQMSACVGQQSVEGKRIPFGFRHRSLPHFTKDDYTPESRGFVENSYLRGLTAHEFFFHAMAGREGLIDTAVKTAETGYIQRRLVKALEDVTICYDGTVRNSTNNVIEFAYGEDGIDGAMVERQKLITHGLNDKEFRRRFKVELSRGGFKKGTLRAGLGDWSPELEQLLEGEFEQLEADRKTLRTEVFQTDRVDTYLPLNIARLVLNAQQIFHIDPRKPSDLSPFEIVDGLKRVLNNLLVVRGDDKISRVMQENATLLFKIHLRSFLCSKQVIEVHHLTREAWEWVLGEIEGQFARSVAQPGEMCGTLAAQSIGEPATQMTLNTFHYAGVSSKNVTLGVPRLKEIINCAENIKTPSVTVYLHPKYSASSESAKIIQTALAYTTLQTVTSAVEVFYDPDPSSTVIPEDRDFVDAFFAIPDEEVEASLERQSPWLLRLVLDRAQMLDKNLTMAEVASKIGAMFGRDIFVMHSEDNAEELVLRIRIVDNDPDKEVQGEEDVFLKSLAQQMLTDIALKGVPGISKVFIVKQDKITRRFDPETGEWDSLKEYVLETDGTNLKDVLAVDGVDVSRTLSNNCVEVFRVFGIEAARGSLLKEIRNVIEFDGSYVNYRHLALLVDIMTSQGTLMAITRHGINRTNQGALMRCTFEETVEILMEAASMGDMDDCKGVGQNVLLGQMAPMGTGSFDLNLDVDMLKDVIVNRDQSYANLWVSKLGMDSDDLGARTPGGMTPYDSGSPNIDDDFRVQQQASFSPLVQVGGDEGGYGEYLSAGQSPMRTPLGAQSPGYGFAPTSPGYVPTSPAYNATSPALGAMSPWVGAAGATSPAYSPTSPRIFAGATSPSYSPTSPSYSPSSPVIDASNARSTYTSRMSPASPNYSPTSPVYSPTSPAYSPTSPQYSPTSPAGPRGRRLGASGPKYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPSGNVGASAASGAASPRRSRMTSRPTWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5K8</accession>
    <name>A8Q5K8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi apparatus membrane protein tvp38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_2790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729804.1">
        <property type="nucleotide sequence ID" value="XM_001729752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5K8"/>
    <dbReference type="GeneID" id="5854105"/>
    <dbReference type="KEGG" id="mgl:MGL_2790"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2790"/>
    <dbReference type="InParanoid" id="A8Q5K8"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP42590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27875" checksum="E6BF3873FED55E5F" modified="2008-01-15" version="1">MYLCILAGAMWGVPVALPIIGACIQVVPRWQQRIDSWKDTVQQYESSLFSYLTILRMMPVPPHFLVNIISPHLGIPMGIFFMSTVCGVFCSSLIYTAIGEGIEQITSSDSLRIFTWKNVTLITIVALACALPAWVKGRVQTPEDNPVQLSSIRLPTNTGQTTDVSWSGRIHNLYQSLLALVHPALRASSEESQDHDERDETGRRDFADESLLAWQEQAFVPGLRTMSSAPPINQDHHFSIGRFYDNQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5X5</accession>
    <name>A8Q5X5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729841.1">
        <property type="nucleotide sequence ID" value="XM_001729789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5X5"/>
    <dbReference type="STRING" id="425265.A8Q5X5"/>
    <dbReference type="GeneID" id="5854148"/>
    <dbReference type="KEGG" id="mgl:MGL_2827"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2827"/>
    <dbReference type="InParanoid" id="A8Q5X5"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="161" mass="18347" checksum="EF68A86E83FD2F80" modified="2008-01-15" version="1">MDNNLLEGVKRWLEPLPDRSLPALNVQKELFGVLETMTIDTISLKMSGLGRVVVFYTLCKRVEPSIRRTAEHLVEVWTRPILKRSASYRDRQVAQAEWHQNSPVNPSNHLHESAFVANKNRRHVGIPQSVTTGFQVAPRNRVAGSTNDHEHQTRLANYQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q5Y1</accession>
    <name>A8Q5Y1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_2829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729843.1">
        <property type="nucleotide sequence ID" value="XM_001729791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q5Y1"/>
    <dbReference type="FunCoup" id="A8Q5Y1">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q5Y1"/>
    <dbReference type="GeneID" id="5854150"/>
    <dbReference type="KEGG" id="mgl:MGL_2829"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2829"/>
    <dbReference type="InParanoid" id="A8Q5Y1"/>
    <dbReference type="OMA" id="INYGDYV"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16724" checksum="6F4FDBD625D69FAE" modified="2008-01-15" version="1">MFAKQFRKHGQVQLSRYLRPFHSGDIVDIVADSGEQKGMPHKYYQGRTGVVYSVFPRAVGVIVHKTVGNRKIEKRVSVRVEHVRHSKCRDNFVNRVKANAAAKHAAKEKGEHVFLKRQPAQPRAEHTITVGENKPVTLAPQPYDTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6E3</accession>
    <name>A8Q6E3_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729953.1">
        <property type="nucleotide sequence ID" value="XM_001729901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6E3"/>
    <dbReference type="STRING" id="425265.A8Q6E3"/>
    <dbReference type="GeneID" id="5854260"/>
    <dbReference type="KEGG" id="mgl:MGL_2939"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2939"/>
    <dbReference type="InParanoid" id="A8Q6E3"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="267" mass="29849" checksum="AB4F4FB81F4E7CC7" modified="2008-01-15" version="1">MRKNGDRAPQDMISNALCDISHLGATNTNSSRDDLSLAPHTRERQHAFWRRYHSCISLFPHLKDSVQHKKRIRDDGDQENIDPWDEELDFFESLDESSWQLLDETSDSSIKASSKLSLDPETSKSSEDQTNFGFQKANGKRVARPSAAAMEQAAKRLRLDDWDDDPPTSTNIPTSSPDYAAKSETSIPTSGRPFCPKGNTSLVNTTACWIIFTTTPRYSGRLSFGPIFSILKQKKISKPASSTHAAIQSHLCRNTSAFVPARTQCQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6G8</accession>
    <name>A8Q6G8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_2962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729976.1">
        <property type="nucleotide sequence ID" value="XM_001729924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6G8"/>
    <dbReference type="FunCoup" id="A8Q6G8">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q6G8"/>
    <dbReference type="GeneID" id="5854283"/>
    <dbReference type="KEGG" id="mgl:MGL_2962"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2962"/>
    <dbReference type="InParanoid" id="A8Q6G8"/>
    <dbReference type="OMA" id="HINCYVE"/>
    <dbReference type="OrthoDB" id="539541at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="5">
        <location>
            <begin position="170"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="287" mass="31561" checksum="414DDA4B1D069420" modified="2008-01-15" version="1">MQKSRLREHYERTLAADMMYMMYEPESGSTSSKDSPALGDGARETDRVRRWSNESPYHVGRSARAQLGNRPLIPLHKPLYMSRHIEHDIPRLERIVFTAFCREAITNKQALLPLLGQMRAITGLPILGSLADPSAGDSPESAGPSARNGYVQVLRARQGAASFKLRVGMPVGVKAVMYGDAAYEFIESLTTFVLPRLRGFAGLSLPPSTQPLLSPAAVSGVVSFGMGPEAMPLFPQVEINMDQYPGRRYGFQVDCVTNQRGRRATERARTLLSGLGLPFVRRGTVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6K9</accession>
    <name>A8Q6K9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730011.1">
        <property type="nucleotide sequence ID" value="XM_001729959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6K9"/>
    <dbReference type="GeneID" id="5854318"/>
    <dbReference type="KEGG" id="mgl:MGL_2997"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2997"/>
    <dbReference type="InParanoid" id="A8Q6K9"/>
    <dbReference type="OMA" id="RSHWSAP"/>
    <dbReference type="OrthoDB" id="9995831at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="417" mass="45225" checksum="A8F7CB22092CD3BD" modified="2008-01-15" version="1">MSEYDMHMSNTSRSTGPHSRRRQGSHFSANTGSLAGVPTAAETATAGRGHANGTESAPVVPQPPTPQHMNISLKDLNGPLTGDSELGGAPPSPSTLTDIILSLHASLYGAKRQVDEIHEMVRRYYDVNAVFDSPLVSAHGRDRIIDQFVLAFALPGLEVRSELRDVICSDFEFDGTRAGIIDHTITVTFFPNLFGSSSQEQDVGIHTPGTSHGNVTPHPFLNYPTSAGHQGAYPMRRHSSGFFSSPRTPSTPFWQPSSSYVGGSNWNTRPRPPAIMQQGSMPSSQAQSSHLSLSPGVIDSHGPSLPSPRDGVRATCTPVTPTTPVARMMSSPVPAMPVDAAKSHWNAPQGLGRRSVWSLLYDLLRPSQALRIIFSLELSLFSRLEFNEAGRIVRHEDTWSVRELVVGMLPFFSLCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q6L5</accession>
    <name>A8Q6L5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_3001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000010">
        <property type="protein sequence ID" value="EDP42801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730015.1">
        <property type="nucleotide sequence ID" value="XM_001729963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q6L5"/>
    <dbReference type="GeneID" id="5854322"/>
    <dbReference type="KEGG" id="mgl:MGL_3001"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3001"/>
    <dbReference type="InParanoid" id="A8Q6L5"/>
    <dbReference type="OrthoDB" id="3366139at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP42801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="543" mass="62086" checksum="D16F8BDC75A3973E" modified="2008-01-15" version="1">MLYDIDAHAQVMGQSRARFVPVARVWIPLIACELTVPILPLHGGSDVLGMCQIQVTWLAQHRACRIKISDVHGLSSNDLNVVHWQLRLGSHTYATQPVDLHWQDPQATCMQHTWKHACCKEWPDAVVATLFAQPTRTFLTKIEAQDQRIELEALRSQVSAHAAQDLAQVMCDDEDKTESNDIRPRHGSFAGSSCRKHERHRRWEQCYGVSMRIHLQEESTWLNLQQQCIVPLQHHSRHPCSVPSWLLRDAPAHLVCVTLTKPATGTVPWTHIKRARMGNVSLVDARGKERGHDARFVPLQRVGVSTTTTSDQCLCLQLLWHRATHDVPEPRAYLDTWHATLCVDVAHDWGMPTLTFTTHVQLKWQRVQGTVPAMWDLTLCAGEHVMYTHYCVRWTPTRAHRLEDLWRVDTRTIQMPGSRLLGSSWHVRGLSLVRDYLAELIWARRLLHALWRGKPEEVPRWEPVQHGRGENNNDSFAMLRAHWRGLSAAKSEAFVGSAEIADTSVCTMRGPLTIQTDTRNDVWSQVWCELRGYVGKERFGYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7E2</accession>
    <name>A8Q7E2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729783.1">
        <property type="nucleotide sequence ID" value="XM_001729731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7E2"/>
    <dbReference type="GeneID" id="5854089"/>
    <dbReference type="KEGG" id="mgl:MGL_3327"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3327"/>
    <dbReference type="InParanoid" id="A8Q7E2"/>
    <dbReference type="OMA" id="PENENAW"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728001" evidence="4">
        <location>
            <begin position="21"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP42569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="381" mass="41604" checksum="529335150356B506" modified="2008-01-15" version="1">MNLSTSLLVFVLLIAHLVSAEFTIPLERRLGPNGKIDYDTEIRHVAAKYANHAMAHFKNTGKHHQSVNGTTLRKRAGTARLDLADNFAWTGEIELGSPAQARWVIFDSGSSDLVMNKGMYNHEDSTTSKDLNKKYSMDYVGGPASGSVYTDQVTIGGVKVKDVVIADNNDVMNGLTSEKRDGVLGLAFPWFSGLSDVSEPNFVDAAKQQKALQKNVYHMTARMNGGSTLNIGKIDASEIDGDLGWVKVNQGDGYWKTDLQINGKKVTGIVDSGTSFVVAPADQYTKIIGGIDKLTVKKNDNGEYNGYYKCDDPPVIKFKLAGKETTMSEDAMYADQDGDQCRISIVSINGFNDWIFGSTFLATGSVVFDFDNTRLGFGKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7F6</accession>
    <name>A8Q7F6_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729786.1">
        <property type="nucleotide sequence ID" value="XM_001729734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7F6"/>
    <dbReference type="GeneID" id="5854092"/>
    <dbReference type="KEGG" id="mgl:MGL_3330"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3330"/>
    <dbReference type="InParanoid" id="A8Q7F6"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728121" evidence="2">
        <location>
            <begin position="21"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="85"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="392" mass="42341" checksum="78D7DC86C4EFB641" modified="2008-01-15" version="1">MQFSFNVLLGLLGTISFASAASFDLHYVPPRDGMSAEERHAAVADHLSKRIASGVYAGLGNETGVDKRSRTASMDLGSNSNGDVWAVKAKFGSNEAEQTMILDSGYAHTLIAKNSGYNPDDSDTVKKTGEDFNANFATGAGNEGTILRDDVSVGGLTAKALAFGYTDSHDFSSDDNLNGVLGIALPNHYESAVAFLWHGWHGIVSVLKHQGVTDEAKYQVTLKKDGGKFSIGEVDDSLYEGELKSVWNLGRFRGMCGFKGSVNGEIRGFVIDTGSPGMMALDSEMRRFLDSLDGVETSTNSKTGTVTGKFNCDSPPKVKINVDGKLDVEIPEDVLTMYDVGDGKCMLPFYGFKNVGVFFKFNWLIGAPFLRQVSYVCDFDSNHMQIAKQASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7S3</accession>
    <name>A8Q7S3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729559.1">
        <property type="nucleotide sequence ID" value="XM_001729507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7S3"/>
    <dbReference type="STRING" id="425265.A8Q7S3"/>
    <dbReference type="GeneID" id="5853865"/>
    <dbReference type="KEGG" id="mgl:MGL_3103"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3103"/>
    <dbReference type="InParanoid" id="A8Q7S3"/>
    <dbReference type="OMA" id="YWVSEKL"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07896">
        <property type="entry name" value="Adenylation_kDNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08041">
        <property type="entry name" value="OBF_kDNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029319">
        <property type="entry name" value="DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050326">
        <property type="entry name" value="NAD_dep_DNA_ligaseB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006592">
        <property type="entry name" value="PRK09125.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810:SF1">
        <property type="entry name" value="DNA LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14743">
        <property type="entry name" value="DNA_ligase_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="75"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DNA ligase OB-like" evidence="8">
        <location>
            <begin position="264"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP42345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37824" checksum="333842149AE52DC2" modified="2008-01-15" version="1">MPSTLTPTKRTPSKPGSSSLSDDALELCDAPMKRQRPASFSTGLSPDRSAHRKTRVPLLLANAWPSNLLDTTDSMQKDPTGWWISEKLDGVRAWWDGHHLWSRNGQVWNAPPWFLHALPRDIVLDGELWIGRGLFEYTSGICRAGHGSTSDEWQKVKFMVFDAPDNASTEPVEQRWDRLRVLFPTAHLGRTSSLEGGHVYMVEQVACDGREHLQSLVQQVLSVGGEGVMLRAPFSVYERRRSSSLYKWKPTLDAEARIVGYEDGQKGMAGFVGSFVCESYNDEYASETHRFRVGSGLTDALRRHPPPIGTIIRYQYGGMGSQGLPRFPRYVGIRSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q7S5</accession>
    <name>A8Q7S5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729561.1">
        <property type="nucleotide sequence ID" value="XM_001729509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q7S5"/>
    <dbReference type="FunCoup" id="A8Q7S5">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q7S5"/>
    <dbReference type="GeneID" id="5853867"/>
    <dbReference type="KEGG" id="mgl:MGL_3105"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3105"/>
    <dbReference type="InParanoid" id="A8Q7S5"/>
    <dbReference type="OMA" id="DYDRPMY"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP42347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="379" mass="43250" checksum="8774CBDCE0D6AC20" modified="2008-01-15" version="1">MHSHHSHSGEFCRHASSTLDQVLARAYELGFTHFHLSEHVPRWRDAHLYPEEREVGMTPDSLTSQFQAYLVKARTLQRMYENMPRPMHVLVGCETEHIESPHSLDALARLLESNTQLSSLSPTQLLPPPPCIGRGLVDYIVGSVHHIRGVPIDFDRPTYEMALKSGQRDQKRHMTMLQAYLDAQFEVMDRLRPEVIGHFDLYRLFEPYASWYPDNSTPDGRAIHAKLKRNIHFAASYGALFEVNSAAFRKGWTDETYPGRHVLRMITKACGRLALSDDSHGTKQVGLNFARLREYLLNEGISKVWYLTPSKAPENGPATSMDNIHLNYESAERARKTREQSMTPGTGAPTTFLRGTQAHCMEDWHTSPFWSTLPQDLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q815</accession>
    <name>A8Q815_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729637.1">
        <property type="nucleotide sequence ID" value="XM_001729585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q815"/>
    <dbReference type="STRING" id="425265.A8Q815"/>
    <dbReference type="GeneID" id="5853943"/>
    <dbReference type="KEGG" id="mgl:MGL_3181"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3181"/>
    <dbReference type="InParanoid" id="A8Q815"/>
    <dbReference type="OMA" id="HWADRIM"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="81877" checksum="3405A83EBB849155" modified="2008-01-15" version="1">MMLLQRMASLESKFEQLIERLDTVTSPKKEAPPPAKQPVDPPSEHTEWNTHHVTNVSSMLSMFLQPTDVHQRRRVLLCMLHHMPPAPLLDAIFDSFRHEVQWINGIVDKAYLQSCMSDIVLLQDALREKSDFFNQLCLSDLSRYIYSVAVSLSICATAVVFSRDAQLNAFQGSTDSLPLYQRYIREALLGLSALSVFDEPNLNFVIIMVLVLSCLSFSRLPGIASGIISHAVQVAFLLDLDMEPPESMSYEEAYRRVQLYFVLCAHDWFSTMAIKRYPLIPNDKERLPSLFGSAEQRSKYLSPYQQMKLKLAHLFCRSSPLIIPQKENYAYIRQLHDEALEVQSSMPNIWLDPHNSTMSTLCAKMHRMFGEGALHYLLLRIHLQYYMRGWDDETYALSRDTCYASARSLLRLFREAFSWKIRNEGCGNACESFVPDEISVPARMWYFSHWCTAAALLLLKHVTMLNERNGHASWDHERESIVEDLCIMSRLFQYLSPVLSYAREGYDAMQRVASHALQKDIDTAQLSNTNCVTHWADRIMPHRTHAPSSEPMSVLNTLSKRNEFSSVAHSTSQASSTPSISSHPCSSLESATTGLSSAQQSPNFRAPSNTSSVSGPSSDVKYGVGHILAQICCTTSWLINTAATGSQQDMPYPVLPEPSMFLMQSHQAPIPVDADMALMLQQKDLLDTDPLSSNVGSLTPFADDFLRSLDNIPPTLDSNASAPLPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8A9</accession>
    <name>A8Q8A9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729693.1">
        <property type="nucleotide sequence ID" value="XM_001729641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8A9"/>
    <dbReference type="GeneID" id="5853999"/>
    <dbReference type="KEGG" id="mgl:MGL_3237"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3237"/>
    <dbReference type="InParanoid" id="A8Q8A9"/>
    <dbReference type="OMA" id="FSWRTIA"/>
    <dbReference type="OrthoDB" id="3346251at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002728131" description="DUF6533 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="4">
        <location>
            <begin position="72"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="544" mass="61579" checksum="208EA5ECA53B9D42" modified="2008-01-15" version="1">METSRARWNALWLCFALLLLRVLAAAGAQQGDDGGGSDHGSDNNDPDTISDPTTNRRITKSQLAYQLKVAEYVCVAGLTLYAWEYLMTIGREISMWLHPRSLLHPQVALFLLIRYVSIPPLVVTSYSLWGHFSKAEECLKHEQMTVAIVQFVVSCVFSWRTIAIWRRKRWVIIFMIMLSLVLFGTTIGLLYFSRDSLVVAGGACRPAFDFDGEQPSGVNTVKWFYLCAMIFDTVAMGLSTYKLFTYANMGRRLQKITFRDPFEMHRQQLEKSQVGPTYVPPDQLGTDLDPYESECVRPMPHVVRRWCSNIASVVLIPYHTVHSMYNWWMSLTPLVARLLRNGIVFFVVATAYNVNNFVLEARNALHSKSFLALYSPLMCVLCQRMLLREFDEVWSSVDVDLEYPGRQLVDRVVGPTAPTSSQTPQLDRFERFASALEERHASLMSPTRRRRSDSEAQMPPSSPPSNETVQAPSSAEKEPYTDVPNVVLPTPSRNLSFASIHVSPRTSNVFTGSMQPPAPVFQSFTPPKLTYAQEQQALRMAGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q8I9</accession>
    <name>A8Q8I9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000011">
        <property type="protein sequence ID" value="EDP42521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729735.1">
        <property type="nucleotide sequence ID" value="XM_001729683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q8I9"/>
    <dbReference type="STRING" id="425265.A8Q8I9"/>
    <dbReference type="GeneID" id="5854041"/>
    <dbReference type="KEGG" id="mgl:MGL_3279"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3279"/>
    <dbReference type="InParanoid" id="A8Q8I9"/>
    <dbReference type="OMA" id="WHASNAM"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP42521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="51273" checksum="3639F9242568437B" modified="2008-01-15" version="1">MLGSRFQYTEHQTPMPALLAIRTRAIQLLEWVAYPPDDDTSVDTMLRASFAFSNETSRAQSDALWILGEHYFWGTHGAAPNMTKAYQAYERLARTGNATAHSRLGYMHSSPFLAKVHGFEGSPTEAILHYTIASQKGDWHASNAMAYRLRYAIDVPENCTQSLELYEQLAQQTYKMFLDVPPFGRRLPYSKVRLTDRRWFLTTWRHFVSERYEKSLSKHSIAHPLGEHVNEIVRSLVDRDLLQDLIRFWAIDDGENPLSQYELARMHYYGSTVVESEAQGAVIPSADLAFDRALHLAKKRWPQGIHLRHVDEEVSDFDLAPNNDNSKQLAFAARSAAQMLGEMYLRGEHHRQDFIKAKVWLARAHADGDLLSSTYLGMMYMYGYGGMAPNTTRGMELFEKNSHTSDLAALEMGKHELRTYKHLESLTQVTTTRKVPTVCLRAHATKVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q933</accession>
    <name>A8Q933_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729366.1">
        <property type="nucleotide sequence ID" value="XM_001729314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q933"/>
    <dbReference type="STRING" id="425265.A8Q933"/>
    <dbReference type="GeneID" id="5853673"/>
    <dbReference type="KEGG" id="mgl:MGL_3401"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3401"/>
    <dbReference type="InParanoid" id="A8Q933"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="115" mass="13390" checksum="EFFAC698BC1E9FAF" modified="2008-01-15" version="1">MSSSNVDRQMLKQCRELILQNQWEPALSKANAILEFHHENYHALVFKGLALLHLGQYAESEAAYSKATRIDPIQMLAWQGLEKAYESQKNWLKLMQMLEEVADLARREYVRAEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q936</accession>
    <name>A8Q936_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729368.1">
        <property type="nucleotide sequence ID" value="XM_001729316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q936"/>
    <dbReference type="FunCoup" id="A8Q936">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q936"/>
    <dbReference type="GeneID" id="5853675"/>
    <dbReference type="KEGG" id="mgl:MGL_3403"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3403"/>
    <dbReference type="InParanoid" id="A8Q936"/>
    <dbReference type="OMA" id="HTAINYD"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP42154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="831" mass="95141" checksum="9A10B9233FDE9923" modified="2008-01-15" version="1">MPPKKVLLSTRERALFSRLIQEYENRKYKQALKTADAILEKVPTHGETVAIKGLVLFSIHQRDEGLALAKLGVRYDLTSFICWHALGIVYRMDRNYQESLKCYAQALRIEGGNLNLIRESGFMQLQMRNYQPFIDARLVILRTQPHLRPNWVALALAHDLADNKVQAVRVLAGFEDVYRDIPKHNYEYSEVVLYHASLLEQMGDAEGVLKLLNAQRDHIVDEPSACVLRVQALKSLGRKQEATDVCDSLLQWNAENKEWISMYLDVACPVKDSDESRLAILLQLKALFPKSAAIRRMILHLAQGSEFETHAREYLEHALVKNVPSLFLDVKSLYKQQGKQDVVEALVEEYRMLWDPHNPASAHEPPSSYLYAMYFLAHHYSYTGRTSRALHYIDAIIEHTPSMPELHMTRARVLKRAGAYEAAADAMEDARLLDGQDRYLNTKAAKYLLRVNKIAQAAQKLKLFTRPDVPEPLADLVDMQALSHLVEDAEAHERCGENAMALKRFHQMHKIVQDIYDDQLDFHSYCMRKMTLRAYVRTLRFEDCVFRHPAYIRAANDAAMLYAKLHDEPQLREAAEQKKGDETKKPAALNESIDELMAPPDPDPHGIALASTTTPLKDAHMFVTKLQTYAPNDQRTWLTTFEIALRERSWLLALRALSLAFRLDPSDPRLARQFAHFRQAIQSVDRLPDMVQKVLNGLKEEVPPLSIPLEHMYTEYVQHYGNNSALHALGSAELLYVLKGSAEATDVVELVFALFKRDDTSLFVLQAASEFLRRIEAETKNSLPPAMSRASFLSRAREQWPHADAFCPDEHKQQLAKTRYESRRTWLPEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q973</accession>
    <name>A8Q973_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heparinase II/III-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729391.1">
        <property type="nucleotide sequence ID" value="XM_001729339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q973"/>
    <dbReference type="STRING" id="425265.A8Q973"/>
    <dbReference type="GeneID" id="5853698"/>
    <dbReference type="KEGG" id="mgl:MGL_3426"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3426"/>
    <dbReference type="InParanoid" id="A8Q973"/>
    <dbReference type="OMA" id="YWGYGTS"/>
    <dbReference type="OrthoDB" id="3476529at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045:SF1">
        <property type="entry name" value="HEPARINASE II_III-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Heparinase II/III-like C-terminal" evidence="4">
        <location>
            <begin position="627"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="936" mass="103464" checksum="20708315E4137502" modified="2008-01-15" version="1">MSGTDAMVQRGQSYVVDPFEQYTLNAPQSQYDPSRAAAVHNNVTGDAATGQDFATNAPMGDYNFHVGNAAYSQSRQHLLPNSESHLQSDPFLTREENSDAAMRNGTLGGTTVNSATRDQPYGRALDLNEKPPKKHRSSKFKWLMALLAAIIAIIIILAAVLGGVLGSRANDDDDDKNNQSVPRSKIGSGNVQTNVVGTFPQNVFDDASKAASQGNTDPLSYRATDPYGNPMFIAESNTAVPSFGDPAGKCGKDPWKASNNLNNGRPGHPRLIAPKHMWDCLEDRIHNDAYLTAWNYTIMQNATNYVDEDPVKYDVDGGLTLSGILDVSRIVQQRIKAWAYAWRMTHDKKFSDRAYKEMQVAAGNTSQPFGDGDKRWNPDHFLDTAEMASAYAFAYDWMYDAWNDQQKSYIIDWIVRFGLAQGLDMYNKGSAWWSQSSSGNGNWNCVCNGGLVFSALAIQNDVQGDLKSTTDQILSKALDNAKNNCMRAVYEDGTWSETPNYWYFGTNAQARMVSALITATGSDQGLMDQNKNWAKTSEFHMYVTGNAGMFAYGDNGPNKFSTTANQLFLYSQLAKQPMYALFQRDRADAASDPLSMFWYDSTPRGGFFNGLPLDRFFDNDQGSWVSMRSTWTDMSGNYVAMKASNMTGHQTHGDLDAGDFVIDSLGTRFVGEYGSDNYLAKDYFASEEDGATRWKYFRKGTQGQNTLVIGKQNQNSSCKPNIKFESSNTKQNGDLGFTPGGDSTVYTVADLSSCYGKQDNGAVQRGIRFVNGRRQVLVQDEVKKQDKEIQWRVQTNATVTLSDDKKTATLEINKVIDPNASIKQFTASIPPVKMKATILSPDNAQFEAGPAYDKKSKMPNYYYGADAIPKQGTDDNGHAINPEVPDLEVTVLSITLPGDVDTNIQVWWQPEYAEAIDADKNPPKSVALSDWSLTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9B4</accession>
    <name>A8Q9B4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_3450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729415.1">
        <property type="nucleotide sequence ID" value="XM_001729363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9B4"/>
    <dbReference type="FunCoup" id="A8Q9B4">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9B4"/>
    <dbReference type="GeneID" id="5853722"/>
    <dbReference type="KEGG" id="mgl:MGL_3450"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3450"/>
    <dbReference type="InParanoid" id="A8Q9B4"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="275"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="532"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP42201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="573" mass="63585" checksum="C5659B285632FF85" modified="2008-01-15" version="1">MKYIVVSGGVISGIGKGVIASSTGLLLRTLGLRVTSIKIDPYMNIDAGTMAPTEHGEVFVLNDGGEVDLDLGNYERYLNVTLTRDNNITTGKIYREVIEKERRGDYLGTVGDIESAPFVEALRQFQFRVGKENFALIHVSLIPVIGGEQKTKPTQAAIRDLRGLGLVPDLIAARCAAPLERHVINKLSLFCQVGPDQVLGVHDVSSTYHVPLLMEAQGMIRFFEQRLHLDLRRDVPSSRVSDGKELRRRWKELTMSRERVFDTVEIVLVGKYTALQDSYLSVTKALEHASMQCQRRLLIKWVESGDLESHTEHEDPVKYHQAWQHLCSSQGIIVPGGFGLRGTEGMILAVRWAREKNVPFLGICLGFQLAVVEFARHVCGRKHAHSAELHPECKDPVIVYMPEISRTHMGGTMRLGLRPTLLSDASASWSKIRRLYGGQSIVWERHRHRYEVNPEVVEAIEAGTCSSGARLSFIGKNEQGNRMQMAELQGHPYFVGMQAHPELASRPLNPSPPFLGLVAAAAGILDEQMKHQMHGYKPPHPSSAMVLESQSDQLAEQATVAEAGQSGTSQQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9M1</accession>
    <name>A8Q9M1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729471.1">
        <property type="nucleotide sequence ID" value="XM_001729419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9M1"/>
    <dbReference type="GeneID" id="5853778"/>
    <dbReference type="KEGG" id="mgl:MGL_3506"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3506"/>
    <dbReference type="InParanoid" id="A8Q9M1"/>
    <dbReference type="OMA" id="MEWNDGS"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="301" mass="33976" checksum="83AABF22F3D09F61" modified="2008-01-15" version="1">MSSEAAGPRVRNVKFKLDENDPSAPVVGAEDGNVDSSSETLRSPRKSVLKQRQSGSIPPPSHYQHPDPLLRRLRLRDGYGNPVDLRSTFREAKLVLFYFGSQWNASESRGCQRLVSDLCREYPHELKTVYISVDTDVKHYEAATRNRPWLSMEWNDGSSLDPDKEESAQEVPAENFLLADDPDTEEFVVQSDPAGTSYVRPLSRVYMASKFEVLITPTLVAYHIPTRRILDHNVRLSRLRSSRAKDTLSLWLKGEPSPSMNFVDILYITPLSFVLAVVVLLYLCMRITMGDQVSLPHLIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q9T2</accession>
    <name>A8Q9T2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_3557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000013">
        <property type="protein sequence ID" value="EDP42308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729522.1">
        <property type="nucleotide sequence ID" value="XM_001729470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q9T2"/>
    <dbReference type="FunCoup" id="A8Q9T2">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q9T2"/>
    <dbReference type="GeneID" id="5853829"/>
    <dbReference type="KEGG" id="mgl:MGL_3557"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3557"/>
    <dbReference type="InParanoid" id="A8Q9T2"/>
    <dbReference type="OMA" id="MKVIASY"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP42308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="11593" checksum="B2CEDCDF715DFA8C" modified="2008-01-15" version="1">MKLIAAYLLLSLGKESKPTAEDVTKLLSTVGIEADNERLEKLISELDGKDVSELISEGKEKLASVPSGGAVAAAAPAAGAGGDAAAAPAEEEKKKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA65</accession>
    <name>A8QA65_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_3624</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729157.1">
        <property type="nucleotide sequence ID" value="XM_001729105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA65"/>
    <dbReference type="FunCoup" id="A8QA65">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QA65"/>
    <dbReference type="GeneID" id="5853463"/>
    <dbReference type="KEGG" id="mgl:MGL_3624"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3624"/>
    <dbReference type="InParanoid" id="A8QA65"/>
    <dbReference type="OMA" id="KKWIMRA"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="194"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="637"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP41943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1144" mass="124693" checksum="410C227A480A489C" modified="2008-01-15" version="1">MRAGHSTLPIFEKSPEDGWHSLKEHMSGSPDRIPDMGFADWLVVIDESSETSDLQAQRRDYLLPAITKALQEESQGRCEWPVSRFTDTNQTVGDVVICFDPQSSYDTSHMRHLLDTKTLQRVLAHAMQTIPPDMDPTLVSRWKRGDVWLQPLTPTSHGPEAFMKESVSLEWLISLVGSAFWRAWIVIHQADPIDFTVLLAAYIMMHGSFVHLYVSMSHFPKRFWLGTCVLLSSSFAFLLALVSANMLSLPVDPVILSEGLPFLVITVGFEKPYLLTKAFFSQSAPETKTHTDMTPHSRGTPEDDFVRALTQRVQEEQELGILVATPKPVPDVAVRAVSDAGPGLFRAYGIEMSILLLGILSGIHGLREFCCLAMLILFFDSLLLFTFFLAVLCVTLEVNRIRQPLVTPEVQRESDKDTPTEAPAEPQVRGPPKHKSSHLSLYQRVFGSMDHPLSRLKFMLLFALVALHSLNMLSTLSLPTTIARHHTARPRTMYEEVVSSSDMFRASMTHPAMSAFFHVYDMFSAAHAVAFMPPSVLILTDRAHTVSGSLAAAAMKTATPRYTAFDSFMHTWTSVASDPVIGKWLSLALLLSVFLNTFLLKGIAMRNPAVIEGNAVRVTAQAAARLIGAHLEEDWYKTPKTREEPSSTPRVTFAPPPPSVPPPASSDPPRPYNELRTLFDKEGPGALNNEEIVLLVQKGVIAPYALEKVLQDYQRAVLIRRAVLSRASETHMLENSLLPFKDYDYASVFGACCENVVGYMPLPLGIAGPLVIDGCMTPIPMATTEGTLVASTSRGCKVLNANGGVTTVLTQDAMTRGPVIEFPTLTSAARAKRWIDSGHGADEIKAAFDSTSRFARLTSLHTVLAGRTLYVRFATSTGDAMGMNMISKGVEAALGMMKDKHFPEMELLSLSGNYCIDKKPAAINWIEGRGKSVVAEAVIRGDSVRSILKCTVEDLVRLNTKKNLVGSAMAGSIGGFNAHAANILTAMYIATGQDPAQNVESSNCMTLMEAVNDGKDLLVSVSMPSVEVGTVGGGTGLAPQRSMLELLGVQGPNRDTPGANAQRLARIIAAAVMAGELSLMGALSAGHLIKAHMAHNRSAPPTPGTMSPMPRDQQYKPTMTPLIATPIADVSQRKGLTPMTGSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A8QA76</accession>
    <name>A8QA76_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP41954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729168.1">
        <property type="nucleotide sequence ID" value="XM_001729116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QA76"/>
    <dbReference type="STRING" id="425265.A8QA76"/>
    <dbReference type="GeneID" id="5853474"/>
    <dbReference type="KEGG" id="mgl:MGL_3635"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3635"/>
    <dbReference type="InParanoid" id="A8QA76"/>
    <dbReference type="OMA" id="WADEGPG"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="152" mass="17718" checksum="A139F466AA0D5C02" modified="2008-01-15" version="1">MGYAYESLEDIDPFLENPYEGNSMTLLLARELSQRLDCYVVAGFPERASSHTFRELEPTEKRHDARHIEEKNLESAHLPRISRKAYNAALLTDQKGKLVKVFRKHFLYEADTPWADEGPGFEYVELPGIGRLCVAICMDLNRAYYFYEYRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAK0</accession>
    <name>A8QAK0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000014">
        <property type="protein sequence ID" value="EDP42078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729292.1">
        <property type="nucleotide sequence ID" value="XM_001729240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAK0"/>
    <dbReference type="STRING" id="425265.A8QAK0"/>
    <dbReference type="GeneID" id="5853598"/>
    <dbReference type="KEGG" id="mgl:MGL_3759"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3759"/>
    <dbReference type="InParanoid" id="A8QAK0"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="344"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP42078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="702" mass="75039" checksum="E6B41D02F41D4E99" modified="2008-01-15" version="1">MVESMNSHNPFLAHVSAKPTSESKGSALDDLVGLDLSTPQPVAAPVSNELQASNLGGNVDGMSGDMPGGFQDPVSPEQERLPTTPLPNTKNPFLSAAAPTALVSASHSLQEPQHAFNSAVTEHTSSFLPEDVGTNDPDADEFQDADTSLPRRVSMKDPSYFPETSAGMIRPISSATAASTLYDARTLTAASPFPSTTGPFVASTSSGAASTPINVLSSPERSPFSAPGMREGVVPSMNPYVQHSTPADSRTGSLVPVEQGVPGLGQPVASTRAGVAQPLSYMPSLSSSSTAVPVGVRTPMTSIPASTTGTQGSSAANADTQAQIDADAKLAQSLAATNISDETQWSVKDILWRGRNTKIIMQNANGPCALIALTNVLLLQNQIKITPPDRPAVSYAYVSDMLADYFLEHSTGRADAVELSHVLSTLPKLLHGFQVDVFFDRPTHFGSDIGADTSAELSLFRMANVPLLHGWLPDPSDAPTCEALQQVRSYNGATALLARQDAGDAADLSAARVGDFMRMHATQLTPWGLQALSQELLPGQLGVLFRNSHLSVIYRRRVDEGMSSSPQLYMLVTDSAFLMDDRTVWESLQDTRGSDTRFYDADFERVMRSEREWGVTANGLGSGTTDDYTLALRLQNEERERARAVQRARRMHADVYRDPQRSASTPTGSSSSKKFSKMMPKMRRKEGGGGDSADDGKNCKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAL5</accession>
    <name>A8QAL5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_3774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728986.1">
        <property type="nucleotide sequence ID" value="XM_001728934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAL5"/>
    <dbReference type="FunCoup" id="A8QAL5">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAL5"/>
    <dbReference type="GeneID" id="5853293"/>
    <dbReference type="KEGG" id="mgl:MGL_3774"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3774"/>
    <dbReference type="InParanoid" id="A8QAL5"/>
    <dbReference type="OMA" id="KDYTVMT"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="26"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="498" mass="55353" checksum="28A3BA108E29B83A" modified="2008-01-15" version="1">MVKRRRKTRTHLKGPINNSQTDARAPKSFVIRGGRVGKSVSTLVRDVRRVMEPNTAARLQERDKNKLRDFLTMAGPLGVSHMLIFNQTDAGINMRVLRCPRGPTVTFRVNKYALVSDIMHSSRRPSAPGSEFTTPPLLVLNNFGGQERHLKLLVSVFQNMFPPLHVHSMRLSQVRRVVLLNYNADTKTIDWRHYQISVRPVGVSRSVRRVIEGSTRPSAVSSGSVSGYGGEHRRHGRALVNLGNATDIAEYVMRGSQATGGEDTDTSEAESEAEDMADPQNSVELSQQYLGRGNAAHSQRAVRLREIGPRMELRLVKVEEGLNGSSVLYHDYVHMSAAEVAKQTRDITAKRQLAAERRAEQERNVERKKQAKQTHKAASLAGQNGGDGGAWEDEDDYSDKDNDVEGHEGSDDDEFAYEDAAAGAPANNNDIAQDILASDEELFDEDDDEEEDVAEHAPDSDEEDDSDLDPIPLGQVEYDEPVTSKHRAPSKKSKRQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAT0</accession>
    <name>A8QAT0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_3824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729036.1">
        <property type="nucleotide sequence ID" value="XM_001728984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAT0"/>
    <dbReference type="FunCoup" id="A8QAT0">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QAT0"/>
    <dbReference type="GeneID" id="5853343"/>
    <dbReference type="KEGG" id="mgl:MGL_3824"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3824"/>
    <dbReference type="InParanoid" id="A8QAT0"/>
    <dbReference type="OMA" id="YFVQFIA"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="9">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP41822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="350" mass="38303" checksum="5B4B1EFDC0FB3C35" modified="2008-01-15" version="1">MSNQGGKQQRQSNGGTFAGPNSNNMFGANMPSSVYPKDSVKDVAESLGITNLRDNIATALATDIEYRIRDIVQSASKCMKHAKRTRMTTSDIDHALRQKNIEPLYGFYPPYTGGKKQGPWFRTVPTTSGAPLYVLEDEEINFEHILEHGPRVGVGRGVGWHAHWLAIEGVQPPIPENPVPLTRKMAGTDDTSLADAGEAAAELGNTAVKPLVKHVLSRELQLYYERLTSSILSPPTDAETETGTALPQEGMPLSNYSDISSGNLVRDAALSSLRGDAGIHQLVPYLIQWVGSNVTHSLRLPPTAQDPEKKLEEQKHTIQLLHTMLSTLHALLVNTSIFIEPYVSTKQHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8QAW5</accession>
    <name>A8QAW5_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729055.1">
        <property type="nucleotide sequence ID" value="XM_001729003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QAW5"/>
    <dbReference type="STRING" id="425265.A8QAW5"/>
    <dbReference type="GeneID" id="5853362"/>
    <dbReference type="KEGG" id="mgl:MGL_3843"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3843"/>
    <dbReference type="InParanoid" id="A8QAW5"/>
    <dbReference type="OMA" id="GHVQKFT"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="124" mass="13556" checksum="47F47E71A570B7C3" modified="2008-01-15" version="1">MFAVAQRSMMSARTAGFRALSSSAVARKDILQEAYLRELKAYKAPEKSPDAHKGHVREFSSPPSPQAPSMPSSSEIASQLESFTSSEPDLAPKPAASQEAVSEQQDVNEYLRELQADIKVEAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A8QB02</accession>
    <name>A8QB02_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_3862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000015">
        <property type="protein sequence ID" value="EDP41860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001729074.1">
        <property type="nucleotide sequence ID" value="XM_001729022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QB02"/>
    <dbReference type="STRING" id="425265.A8QB02"/>
    <dbReference type="GeneID" id="5853381"/>
    <dbReference type="KEGG" id="mgl:MGL_3862"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3862"/>
    <dbReference type="InParanoid" id="A8QB02"/>
    <dbReference type="OMA" id="IWEETHA"/>
    <dbReference type="OrthoDB" id="2240312at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP41860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="445" mass="50603" checksum="D27B3A995D191299" modified="2008-01-15" version="1">MYKSRSRRRRYMLARMPAARQVPDDVIIWEETHAEKLAKTTARTGSCTSNSSMLDEPDHVISIDKQIKHLAEFLYRTADSDTECLLQVLRRLVDVPHPVIDTDTSVDMMPNYRAWTQMYPVPPICTGRDVHAVIHYLRVHEYVHIDNPNESNMECVTVHWHPEKCLESKLPFHLADIVDIRAWSKFTHQGEMHVSMDAQEALMQQLYAFLVHVMYEIVTVAERSQVPTMVDDQLVWTCIARLGLVSVNLSLNPDLLASMARIRAVSEPPVAWASMSDPSHNDVPREDCLSDQSLSEENSSEEEMLNSMNEDDDEVLSDESSSAVTDDSYIADSFIDDEPVVSELEGTIGTFGTLVPFEYAPALDEEIHCEPLRSPIQSETNGVDVEEEGEEEEEDIEEDETVLDGHIDVQDERDAQQYVTRLRHDWIEQVSTNVSDGESKRPSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8QBW7</accession>
    <name>A8QBW7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_3948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728954.1">
        <property type="nucleotide sequence ID" value="XM_001728902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QBW7"/>
    <dbReference type="FunCoup" id="A8QBW7">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QBW7"/>
    <dbReference type="GeneID" id="5853260"/>
    <dbReference type="KEGG" id="mgl:MGL_3948"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3948"/>
    <dbReference type="InParanoid" id="A8QBW7"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="419" mass="46957" checksum="5D36C5CB37C3B45D" modified="2008-01-15" version="1">MRDLKAVKWIDSQNLADVHTATYLRELEARGAPKLQHNETFGLLTMRLMERPRDSSLALPRSSTWPVDASMGLSCDHPDALTYAHCVLASSDLLASSLEVDMENVELEMKPEHAIHQDELSLDFLRVAHTNLKSQWEQAKSLPDVARCIQEKQPSALSYFYYQAASGQHVFMHPIDIKVLLSHFGTYAAFPDTLMLAVQHVEEGTVDETLRKKCKYLAHLPMSTDISFVEIDWARTSALLGPIQGEIPWKSWSSTLSQRKQRRLEKASKEERARQRAEKDSKDARSRSAAEHCEREAPLVYSAETSELSFRDSAMVGAEMYFPIHPGAKEDPAALFPSMPSQSSTQTRSGHQPKTVWGTPAATSIHTDATPETRHMDDAWNALEARSSIDVPSQSHDKSKQRTKRKPKLILTGGGRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC06</accession>
    <name>A8QC06_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleoporin Nup188 N-terminal subdomain III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_3959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728965.1">
        <property type="nucleotide sequence ID" value="XM_001728913.1"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QC06"/>
    <dbReference type="GeneID" id="5853271"/>
    <dbReference type="KEGG" id="mgl:MGL_3959"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3959"/>
    <dbReference type="InParanoid" id="A8QC06"/>
    <dbReference type="OMA" id="SEIWVEH"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="8">
        <location>
            <begin position="624"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP41751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1822" mass="200301" checksum="8BD58CBC6D99D77D" modified="2008-01-15" version="1">MLVARLAQLEQCGSILHRKTKESCKILDNKKEITWKGMAFQIDSVQRDLCLAISDQLDIDELEVLVLLRTYLESEHHSIGMLEHKKSLKSDGFDEFLDAFYVFFFEEQLAVIRCVSALLRIAEDAHNELFDIATSVLDKFADTKLAQRCLKWFEEETSKPLPSNVASDTHYAMLWVRQGLERQLALLEVAFLLYYGRVPPCAAFTADVLECAHRTQFGQRQANASIFDSDAYEKCQCIRDLLVFLAVECLNLEAALDVVPEGVSASEDPALAPFASDIDALNRSIAQLEMAASNVAYSPLLLGFALVLRRLEEAGTHSTLDPRLAAAVDVMDNGPPIWRRLVQGAFDPSMELYGMLRALVSSPLLGTGTRTLGASNLSALAYRAVFKGLLLTITDLVHPEYFTDIDTLVDLWCCTFRAKADDVPDGIAALCTQFWTQDIQYPTRASLLSLARRRFPASFRPLVLLMQALSGTMPGSSSPETAMAVIDFLAHVSSVALTLPKIAASLAPWQTIDELEAPSVTYQLRSDMQISSTRVILPAGTRGVLVSPPGEVPAIVLWQPVEPISAWHILHDALLARVSTPSRRLDAFEGGDGPWSLSPDWSNCTASLDIEVAGLFTDVLQAEDSIGETLLSHLGEHEGLVSAALGLVRAALTSSPLGVRRLCHGYRLLMALLPHRSNEIWQWIRSTNILIGSPGIVPLSDVESPHSALLAHEKNTGTFTGTLCLLDLLYALLEQTQSSQFIDPPQLVQVKASVLARSFAWVATDIWNDHRNWTYNDNSTWMQISLKCMRLFSAVLGDPCLNPLKKPDTPLHMDAVRSLHEVVERVLGEGATSLTLAPMLVALGTGHARIDALYRSGHAFAARLLERLVETCLSTTSMLVTRSQRSHLLTTLFVSAAPDARGTLASVILAYIPAAVPPSLATAAAHLVTDIVRAPDVAALRLAGHLGSTNQVEDVVGLLLDVLENSFADTSLRVALWQMFSAFVSSQPALATLLLTGAHLAHDHAYKPSDSSALKRTALQLAVDSLVLTEDLWTVCPELLDAILGFMTEAWEHAVAHPIVFGALRKQPEFWDRLDRIICKKVPVPLLDSSDLLFEHVQNEEATQYAFQLECQARALRIMELDLCTLKMPRQSSGSSCCIRVLEALCSDENRFIEILHHAMQTMPMAVPRSVEQHAGSLARDIPWPILRHAPRRDDYDRQRIYGPYYIYHLPSVLLRSQTTTSADVEELASCVGFTWSIVDAQAKRARAWTDCLGGVMAHLLAQAEAQGSAKYEALQRSLSRTVTHIGPLALAEDRSHVVLLLAVLVGASYMNLNKETLSQLCPLVAQLCEYPAYKLPSFASQSVRTPLVQLMLTVSSACHRQNVSEPALSSILSYAMEALVQLDSLIPFLDAPVDEAARAAEADLDVLIAFLRTCMTTETSVPKSTWLTPMRETCIIPAAASILRCAPLTPEHNGAGAPRTHIRFFMPVLRLIEALSAQPVACELVVQAGVVRALCTTALSALLEQGALDPVLPSGDPHPLHVTWLLMLRTVVRLVENLGLESRAYLVDADVQAFVNMYALQIRRSFLFSPLTQPSPVEIGQLHEVCMVLRLFRSMWMAKAQGAISSDSPMSRARRMPLGEYFLQDIPLLLQQIAYVYNHPKELLTMLGLTNHAGAPTESLSKFAQQTVKEALALLLGLLWDISGADAILTFDKEDWPMLPAVIQPSMHVAPHAPASFGTLLQLASGLTEDTKHDQDVCGLLEQCVGLCVTQAMVWDQGPVPIYANECVQVGRDQARAELEAGLGRDIDAAIQTASNAIRNPWWDVLRAFHERCTRPRSSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QC28</accession>
    <name>A8QC28_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_3968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000016">
        <property type="protein sequence ID" value="EDP41760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728974.1">
        <property type="nucleotide sequence ID" value="XM_001728922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QC28"/>
    <dbReference type="FunCoup" id="A8QC28">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QC28"/>
    <dbReference type="GeneID" id="5853280"/>
    <dbReference type="KEGG" id="mgl:MGL_3968"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_3968"/>
    <dbReference type="InParanoid" id="A8QC28"/>
    <dbReference type="OMA" id="ECMNDIN"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP41760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="235" mass="26340" checksum="4364702423F0648B" modified="2008-01-15" version="1">MAQDFGVPIYALDLRNHGSSPHADSMSYLDMAGDIRKFFSDHKLSNATLIGHSMGGKAAQAMALDPQLPEGMLSHLVSVDMSPAEGPISPEFMRYAECMNDINNMDIKSRTEADKVLEQIEPELSVRQFLLTNLERDGDTMRFRIPVDAILKSLKAIGDFPYAPPSDVPSQPQYQWYGPTLFIKGTRSKYINRHNLPLCKAYFPNMELEVLDTGHWCQAEAPGPFMKSLKAFLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A8QCJ3</accession>
    <name>A8QCJ3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_4015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000018">
        <property type="protein sequence ID" value="EDP41634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728848.1">
        <property type="nucleotide sequence ID" value="XM_001728796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QCJ3"/>
    <dbReference type="STRING" id="425265.A8QCJ3"/>
    <dbReference type="GeneID" id="5853154"/>
    <dbReference type="KEGG" id="mgl:MGL_4015"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4015"/>
    <dbReference type="InParanoid" id="A8QCJ3"/>
    <dbReference type="OMA" id="YTSIYRL"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="558"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP41634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="770" mass="86241" checksum="A0FC207AF11E0B58" modified="2008-01-15" version="1">MPDMGLTNSSRRRGRRGKSNAMDTSAWTSSLYSTRDPSQVSSYYLRPYEEDHNDLSVDDSLSGLGSLLRGSQRPPHTPRSYVHSATQNANLSGYDYAEEDKFMERVESEWRQHASEHDGLADADPPSTTPELEKADDPVFEAQPTPQVPGLFRSVLNSTKRDEFLSSSTDEKHKNIHPENTRGDSQFESASGFSLSSSSSVWTVLFRCFLVIAVLFIIYRNVHKFVSSPTPNDPLVESRPWSSAGSGDELRERISVLEGALNRVWQSVGDVGQEMRVSQEKLMHRLSSLEQKGLLRSSLDSLERDVRSLKKHHAEGMSLWQSEKARIEAMLSQHIEQGEKSKNKKDNLAALYDQLSGLEKRLARAEKQVSEASEAALQAKRAFEPLRDFVPDRLPVRYDARSKQIRIDPAFWHEFRKVMPSPRGAGGDDTTIPPWHVFLAEHRNELEELFSHVARADPDTSMFLDKTTFFDLMEAEISRAKMELTTRFNEHVHGLESDVLEKVRKQQESFMEQQDALSHDETGSELQVDQVRELIDAALAVFAADQIGRADYAQYSAGARVIPSLTSPTHEVRVQGTNVHSFTSMISYLVPLPLRFGTRGADSLSYTVRGRMPVVALHHDTSPGMCWPFSGSHGQLGVQLVRRIKVQAITVDHVPAVLSLDGLASAPREIEVWGIAETSQDRERVEQWRLSQAWSDEPAPVPPSPSHVFLGSFVYEAHAGSPPIQTFPVGHAVGSLGLAFRTVQFNILSNHGLRDFTCLYRVRVHGEPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8QD44</accession>
    <name>A8QD44_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_4112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000020">
        <property type="protein sequence ID" value="EDP41563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728777.1">
        <property type="nucleotide sequence ID" value="XM_001728725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QD44"/>
    <dbReference type="STRING" id="425265.A8QD44"/>
    <dbReference type="GeneID" id="5853074"/>
    <dbReference type="KEGG" id="mgl:MGL_4112"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4112"/>
    <dbReference type="InParanoid" id="A8QD44"/>
    <dbReference type="OrthoDB" id="5594612at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037470">
        <property type="entry name" value="IVY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407:SF1">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP41563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44734" checksum="44B1D9924C9549CF" modified="2008-01-15" version="1">MEGVSGSSSLYTPSIWTQSHLSHPSDVDLPHRPPVYIRRTDISASLHAYERLLETSKTFTSCMSAMSKASADMAAALEDCSSLKGAHACGAAFQAACGLHYLKSNYDQVLCDTFWKEFSIPLLSHLDVYRQTVQDRQLAHEKTMSEQSQILKGIELKYQKQDRQRHRDLSSFRTMLSELQRKVNDMEEIKAQHYTEVLENEEYTWNLIAQKVMLLVRAQVDMADRLSSKAVNDPILESIMATIPDPFQSYGPPKRENELFSILQPMISKRSASSPSPTSPNLPSTSDASLSKADMSVSPTNLLTERASRHSQSLFPVDAASESAEADTTLRADPDRSMPGTGQVDKDSTSFSPHADRKLPARLLQSRPSFHMLFGYTHPEEPSPPSPQTQSPHNHNHDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A8QDA7</accession>
    <name>A8QDA7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L35Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_4172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000021">
        <property type="protein sequence ID" value="EDP41479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001728693.1">
        <property type="nucleotide sequence ID" value="XM_001728641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8QDA7"/>
    <dbReference type="FunCoup" id="A8QDA7">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8QDA7"/>
    <dbReference type="GeneID" id="5853003"/>
    <dbReference type="KEGG" id="mgl:MGL_4172"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_4172"/>
    <dbReference type="InParanoid" id="A8QDA7"/>
    <dbReference type="OMA" id="YRTNKHH"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP41479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12558" checksum="FEC1B22D7FA73F69" modified="2008-01-15" version="1">MTRLYSKGRIMSHRRGKRTMHPNVTLVKIEGVENTKDAQFYLGKRIAYIYKAPNETRGQKYRVIWGRVTRTHGNNGVVRSKFRNNIPPAAFGASVRVLLYPSNMYLTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRB1</accession>
    <name>A8PRB1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732236.1">
        <property type="nucleotide sequence ID" value="XM_001732184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRB1"/>
    <dbReference type="FunCoup" id="A8PRB1">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRB1"/>
    <dbReference type="GeneID" id="5856536"/>
    <dbReference type="KEGG" id="mgl:MGL_0011"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0011"/>
    <dbReference type="InParanoid" id="A8PRB1"/>
    <dbReference type="OMA" id="YFSLWEF"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46400" checksum="AA14362DFB70EF23" modified="2008-01-15" version="1">MPLDSSIGEWKSSSQAKGSVRDPQLVDESDTSRAPFTPQVHLSAVNAAGSAYGLFVLDASFFETLVPNHSALFECYLHVKTLLSILHSRSKIHRCTVSLDESEATMRLCFLLDCHLGIQKKHKLTYEDRACLFPAVEMSSPYTLTVQPSLARDWTEHFFSMGKSGECSLHCTRLSCAMRCCVDGPLDGQLRHSIQSEVRICPDDLKEYNVDQETNIYFSLWEFRAAISAAEVLSTHIRLEFAQGGDPLFLHIDARGDLKGDFILATASEPTQAPVARKRSAPSTDRPRMRTQPPQRDAGQTVTSANVMTSSAVTRIPATGNMEARETYLKTLPRRDIKASESQSDDDDLLPIRPKTDSLLSTHVNTAIERQALSPEEQNESSELNVQDIPTYRSQDADELPATQPVEAPRKIFKPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRC7</accession>
    <name>A8PRC7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732247.1">
        <property type="nucleotide sequence ID" value="XM_001732195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRC7"/>
    <dbReference type="STRING" id="425265.A8PRC7"/>
    <dbReference type="GeneID" id="5856553"/>
    <dbReference type="KEGG" id="mgl:MGL_0022"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0022"/>
    <dbReference type="InParanoid" id="A8PRC7"/>
    <dbReference type="OMA" id="PILLRWH"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP45033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="318" mass="36248" checksum="007F26DC785CDA4A" modified="2008-01-15" version="1">MDIQELYSLIDLDLARSSEKLSEIEKKSVAQVLRVWAHMHPEPGYRQGMHELAARLWKLRSSESCLIALATDTQEPNLSTQSIFHVLLMLEEVESDTYFCFSALANRLIPLYYQSERAGSPALIKAILHRADSDLGAHLQAIQLDWVPILLRWHRLLYMYEFPENTCVELWDTLFAIDSTLQLVPYISTVLLLSHRDEIMNGDYIEVMQLLMHMPDIKIPRKLVELALQLYKNPSASTGAAVATSYGQHPPPPEPSSSRIDLARTMLRDLALGLVSQGANPQPTWSPRSEDRLNAETPNHTEQRKRAMLSLDNVHDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRD4</accession>
    <name>A8PRD4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">MGL_0027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732252.1">
        <property type="nucleotide sequence ID" value="XM_001732200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRD4"/>
    <dbReference type="STRING" id="425265.A8PRD4"/>
    <dbReference type="GeneID" id="5856558"/>
    <dbReference type="KEGG" id="mgl:MGL_0027"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0027"/>
    <dbReference type="InParanoid" id="A8PRD4"/>
    <dbReference type="OMA" id="QEMPFPS"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="289" mass="32801" checksum="D10E96E87D7BA136" modified="2008-01-15" version="1">MRSLQEEVRECVQVLETRTTEIFSELAQACSLERTGETVNLRPWVHEKNLTLTQAELLRLVDAAVQHQENQMRLTPLIERIKERDTKQRQTIMRVSELQTELLALLERGERNAKDMKKAESTPIYYNDILEYAQRLARYTSAPRGHRLQEASQVNEATGDTSIAAAQSQKVSQTNSKASEQHQQHHIEFGKSDYNQNATRAMSYYDPVIPETPQELPFPSDRLMRQGILYADAAKEDGVMTEPTDATAQSSTKEEHELVESQKPAVPAVPVLDSFAMDTDDAFDLDLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRD7</accession>
    <name>A8PRD7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MGL_0029</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732254.1">
        <property type="nucleotide sequence ID" value="XM_001732202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRD7"/>
    <dbReference type="FunCoup" id="A8PRD7">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRD7"/>
    <dbReference type="GeneID" id="5856560"/>
    <dbReference type="KEGG" id="mgl:MGL_0029"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0029"/>
    <dbReference type="InParanoid" id="A8PRD7"/>
    <dbReference type="OMA" id="NKISHEH"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="206"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EDP45040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="426" mass="47367" checksum="566E89EDD00BC82C" modified="2008-01-15" version="1">MSSGDGDVGKIEELPEEIRNADVQEIQMRTRMLENELRMLKSEHVRLSHERAVMRERISDNTEKISQNKMLPYLVGNVVEILDMDPDIDEDSEEAANVAPNSRPHGKCAVIKTSTRQTIFLPLIGLVPAEELEPGDLIGVNKDSYLILDKLPAEYDSRVKAMEVDERPTETYTDIGGLDKQIEELVEAIVLPMQQEQKFKNLGIKPPKGALMYGPPGTGKTLLARACAAQTNACYLKLAGPSLVQMFIGDGAKLVRDAFELAKEKSPAIIFIDEIDAIGTKRFDSDKSGDREVQRTMLELLNQLDGFSSDQNIKVIAATNRIDILDPALLRSGRLDRKIEFPLPNEEARARIMEIHSRKMAVGPNVNFAELARSTDEMNGAQLKAVCVEAGMIALREGATELDHEHFLGGILEVQALKKSDHFYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRP8</accession>
    <name>A8PRP8_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732325.1">
        <property type="nucleotide sequence ID" value="XM_001732273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRP8"/>
    <dbReference type="GeneID" id="5856631"/>
    <dbReference type="KEGG" id="mgl:MGL_0100"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0100"/>
    <dbReference type="InParanoid" id="A8PRP8"/>
    <dbReference type="OMA" id="AMNEYRA"/>
    <dbReference type="OrthoDB" id="3366659at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="216" mass="24231" checksum="EF1BA73F26D1533A" modified="2008-01-15" version="1">MFYMLGRLRRRPGFVGTAFYTFFGGFAGSLFMIPLGIAMSRNSLRSVQDPNHLASALHDTMEQRRRGFVPKQQPLSDAPVSQTVESSGWSDPAATSETSEPIFAPAASSDWSTLEPKSAGLNKKSADAPPASRWDEIRGNRTSEPSKWEQIRQENAKNALPAHVNARQRSSQEHEQKQPLSDYDRAMNEYRAAFERERQGIDVTTGFTEHNEALRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRT2</accession>
    <name>EFTS_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="3">EF-Ts</shortName>
            <shortName evidence="3">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TSF1</name>
        <name type="ORF">MGL_0122</name>
    </gene>
    <organism>
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Participates in mitochondrial translation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732347.1">
        <property type="nucleotide sequence ID" value="XM_001732295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRT2"/>
    <dbReference type="SMR" id="A8PRT2"/>
    <dbReference type="FunCoup" id="A8PRT2">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PRT2"/>
    <dbReference type="GeneID" id="5856653"/>
    <dbReference type="KEGG" id="mgl:MGL_0122"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0122"/>
    <dbReference type="InParanoid" id="A8PRT2"/>
    <dbReference type="OMA" id="FAKWTVG"/>
    <dbReference type="OrthoDB" id="277235at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000402346" description="Elongation factor Ts, mitochondrial">
        <location>
            <begin position="112"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q9HGL5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="406" mass="42310" checksum="0500EA017179C602" modified="2008-01-15" version="1" precursor="true">MRAMRPVAHLARCFCASSSVKETRPSIQAIAELRKALPGTSMLKAREALTASRSPDAPDTDNVEAAIAWLEQTRASDGAKREAKVASRVTAEGTIGLCTLSDGISSPGARAAMVELNCETDFVARNDIFGALARDIAHTAAWFPIVAASETSAVLSDVDVAAFLECPIIPFEASEENKHDVISVRAAITSVVARLGEKVALGRVASLAPTSGGSHGSALVCGSFAHGTASAPPAPQTPVAATFASGRVASLLAVQVHGPLSQRIMSRTATTQHNDHDHDRNGDDERKRQLRALARSLARQAAGFPTTSVDAPSATAAVASDASSETSGALLTQPFVMLLPAAGLDPSVNEQKSVRDALELWSNTYAGQADGIRVAALRRWEVGETAARPSDETSFADQVKEAAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8PRX4</accession>
    <name>A8PRX4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732374.1">
        <property type="nucleotide sequence ID" value="XM_001732322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PRX4"/>
    <dbReference type="STRING" id="425265.A8PRX4"/>
    <dbReference type="GeneID" id="5856680"/>
    <dbReference type="KEGG" id="mgl:MGL_0149"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0149"/>
    <dbReference type="InParanoid" id="A8PRX4"/>
    <dbReference type="OMA" id="HTYLAQI"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF90">
        <property type="entry name" value="CORA METAL ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="863"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="915"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="953" mass="108272" checksum="62ED483BD3036012" modified="2008-01-15" version="1">MREKPTRSSWHSWWPASWRSVPKLPPEPNTSASKNPTTNPSADATATSTQEKFPHTTFAMQEAHASPLTEKQHDDHHARTTRLKFAGTHIRLHPEDLPHDYEPGEVYRGLDEYVAARRSARRRAHRLRRTSGTRESERNQDSDSDSDSDSSDSDSSNGPQVISRLLSFFGDNSDDPSSDSSTDDDDSDRDSDSSTSSTTSRARSSRDVDPSDRISLASGRSRREMAGTSTPGASSAFAPWTPRLSALTGTRRRRKRRRHANRRERPVHIVKASRMARRNARRLRELSGGITEYTLFAPTGDSRSNVVVSQSWRAIWDRMEHYFSYHRQNDGLAGDLGLPMLSSPPAPTTVEPIMGDENLALPSPALELHVPDRAADSPHDPHAEAFEHELQTGRHMSDMPLTPFFRSNISGDVIPSPMPFGSLSTGRATSPRQERMSPFPNHGKVSPIPEEPGDLQLPEAALDIYGYPEPAIADSVKNEDITEASIRSDPWWLDIRCPTYKDMQQLGQHFPLHPLTVEDILKQEQREKVETFERLGYYFVVLRALDENYFRFTKPAERTDDTREKHLLVSPGLVEAQVPSTPLPGNIEPKPNVGSGRVHIETVKSEDAKEGLEGLNAGAVTLYLVVFSYGVLSFHFEDVHKHTDKVRDRLNSSFTMMERSSDWIVHALYDSIVDAFFPYVSFLQHEVEYVNYLSNDLSLTPFKKDERVSKQAKRFFTKPLFAKTRRKRETAFVAEEILRALPKGNAEYVEYLTKRAKKQKAFSTYDAMDQSHFILRLARVREVVIGLTRLLVPKADVVRALRKRLVDMDRPERKNGLLGMYFDDIFDHIASMLAQLQERETSLKYTHSSFFARVSMISIRFQIHIATVITLATMVIDIVFFITLFCTTFSMNLYIPADNQKDPDRPDEPMHSNSRAFAGIASSLVVFPIFLYSYYRYAVFRSKARSKRSMESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A8PSN4</accession>
    <name>A8PSN4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732513.1">
        <property type="nucleotide sequence ID" value="XM_001732461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PSN4"/>
    <dbReference type="STRING" id="425265.A8PSN4"/>
    <dbReference type="GeneID" id="5856819"/>
    <dbReference type="KEGG" id="mgl:MGL_0288"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0288"/>
    <dbReference type="InParanoid" id="A8PSN4"/>
    <dbReference type="OMA" id="NTCARNT"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002727073" evidence="2">
        <location>
            <begin position="26"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="409" mass="43020" checksum="2911E00404463319" modified="2008-01-15" version="1">MPLSMRGYAVFLCCYIACFITFAQSQYSATYYPGINSLPKTSENGQVGTNECGTHSSALSMCQNLYVNSATDFCLWGPKGPGLQGVGASEREVVSYCTKDGRGTRLIPPGTLQSVHFVKTPHYIQISGLGKLSNLNISPQAGGGELDPHGQDGRGNPIGGLVFTSAFGKHMVQAHEWTSFIDDSSFCLRVCNDGDLATTYCKHIYDEMGCVYNMPTTPDQQGIFESCEGQDAEVVGVYTNNGSPSTFYQSQTLNGSPAPPAKPPPAVSQCTKFPSTMLQGSLTQPFANAGMAVFSHENHHKTSSSSSSISSSLSAGFFSPAATSSGQAFNGSSAMKPSMSSSRSSSRTSPVSPKLSSTTSTNMVAETASPSKGPVLDFGGSGAAVSTRDVICIYTWLALALACTVPVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT74</accession>
    <name>A8PT74_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732604.1">
        <property type="nucleotide sequence ID" value="XM_001732552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT74"/>
    <dbReference type="FunCoup" id="A8PT74">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PT74"/>
    <dbReference type="GeneID" id="5856910"/>
    <dbReference type="KEGG" id="mgl:MGL_0379"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0379"/>
    <dbReference type="InParanoid" id="A8PT74"/>
    <dbReference type="OMA" id="GESDACM"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="84" mass="9116" checksum="DCF65EC376C8F8F8" modified="2008-01-15" version="1">MENDHGELVDLYVPRKCAASGRLIEAKDHSSVQIAVCDVDENGKMIPGSTTNIPISGAIRHHGESDDSLNRIAQQMGCMYFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PT86</accession>
    <name>A8PT86_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732609.1">
        <property type="nucleotide sequence ID" value="XM_001732557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PT86"/>
    <dbReference type="STRING" id="425265.A8PT86"/>
    <dbReference type="GeneID" id="5856915"/>
    <dbReference type="KEGG" id="mgl:MGL_0384"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0384"/>
    <dbReference type="InParanoid" id="A8PT86"/>
    <dbReference type="OMA" id="PCAPHNE"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF90">
        <property type="entry name" value="CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP45395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="539" mass="58926" checksum="40674EA2D738F826" modified="2008-01-15" version="1">MSLDETQLQVLMAQGSQKERKYARKIAPVRQDGHLLLTTLLIANMITNETLPIIADPVLGGGIQAVIVSIVLVVIFAELIPQSVCSRYGLFIGAHMALFTRIVMIILYPIAWPVSRILHYVLGPHHGTMYRRVELKELVTMHEVAGGRGGDLKHDTVTIVGGALDMQEKVAKQAMTPIDRVNMIPLTARLDYPTLERIVRSGHSRIPVYQDINASVHASGAWTPSASRKGTISRLGQSFGLKPPVSHFEPALTTESAELERNPLTDDSKALYSEPPVPRKVHRKIVGALLVKQCVLLDPEDAVPVSEMLINALPTVPWDEPLLNVLNVFQEGRSHMAIVSPHSSHATKATVPPKTKIPATLNASSELEQGSAPSTEPRTKSLRSSRLQRLLHRMRGGKESDFDDPDHPMSASGTLPPATVVEQNLVPNAPLGIITLEDVLEELIGEEILDEYDSEGEDDSMSTWEFDASEKIEGPSDMDRESVMTDDQQPSPLVCVKSPKAAYTPTSFQMHDAAVNDPIQLTKPAIAPDGKGTPSHLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTA0</accession>
    <name>A8PTA0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">MGL_0391</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with PEX6; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732616.1">
        <property type="nucleotide sequence ID" value="XM_001732564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTA0"/>
    <dbReference type="STRING" id="425265.A8PTA0"/>
    <dbReference type="GeneID" id="5856922"/>
    <dbReference type="KEGG" id="mgl:MGL_0391"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0391"/>
    <dbReference type="InParanoid" id="A8PTA0"/>
    <dbReference type="OMA" id="WEILSLH"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000105">
        <property type="entry name" value="PeRoXisome assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="458"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="738"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="986"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="994"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EDP45402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1091" mass="118948" checksum="FC3F6C3EE98DAF47" modified="2008-01-15" version="1">MASSTSSRARSSRARVLIDPSLRVSLVHLPTSLCSTLLARDIVAQTVVVEIGTDMESYYCGWTGLAPSASVLSDPNAGECIVMSPSLADMFAPALSNGQEVSLRLFRSPPIPVARKVFVTPQSADDWEILSVHADEVESSMLSQVRAAKQGQVLGVSVGRSSATVIKFLVDRTVPPTRSVKEDIDTNDQHDQISVAVRLSTDTEVAIAPRPRRADEDEKDTPEQREQLAPPPAPSLPPHVLESSSSVSSDGAALLLTDYAWRVLPDSYVPDKEDKLASSVVIPMSMTAPNWRRPSYELVALAFPQGKLTITKISCPTNPLYEPHFVPPLITTTASYRPGAMPNVDAVPNSVAWPERHVWIGKQVRSNIKAVDFDLVRFTKPSPGALREPNIDTQASQVCLTPPMPAKLVGFDAPLQECIGVIRGVHRLRELLASKQGRTDLLNASASLPVVPRRQFPGTSGLLLSGAAGSGKSTLMRAVGEHLALDPTLAYGIKTIDCTQHIENRLTIVRSRFKESMDEASWHAPMVLVFDGLDTLISAQDSSPQQQPADNFRITQLARSFVELAEEVVREHHVFLVATVQSVANLHEFVRNARIWTQTVSLQSPEKDVRAELLRAMVHNVMSRAARDDLCDDLDFVALTSHTDGYHVADLHMLTERALQEATIRCLLESRRISLTMRDFERAREGYTPIALRGIKLERSSTEWADIGGLAETRHVLRETLEWPTKYAAIFANCPLRLRSGLLLYGFPGCGKTLLASAVAKECGLNFISVKGPEVLQKYVGASEKSVRDLFERAQSAKPCVLFFDEFESVAPKRGQDSNGVTDRVVNQLLTQMDGAEGLDGVYVLAATSRPDLIDAALLRPGRLDKALLCDMPKWEDRLDILRVVARKVPIDSDVDLDVWARRTEGFSGADLQALLYNAQLDAIHATLHATSSAGNDASSDHNQKHASQLAYLSIAPTKEADDDSHVALSNADKAALSSRLECILRSSQDPDSRTATPASTSTSSSSASASSSHSNAATTTTSSSANDRPRQKYLVTNKFMESSFQQTRPSVPAAEVARLRRIYAQFTGERDGKGLDAANMDAIGSHTSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTJ3</accession>
    <name>A8PTJ3_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0433</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732658.1">
        <property type="nucleotide sequence ID" value="XM_001732606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTJ3"/>
    <dbReference type="GeneID" id="5856964"/>
    <dbReference type="KEGG" id="mgl:MGL_0433"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0433"/>
    <dbReference type="InParanoid" id="A8PTJ3"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="90"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP45444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="215" mass="24578" checksum="67469B283C55757E" modified="2008-01-15" version="1">MPPPQHRWRRALSGLLIVTLLTHAFLTLTGNVIVQSWRHDPSCMWTRICMTVFLCGMSAWCFVTVVSRPSFYVHDALVNPMSVTVKRSNGGPRWCSKCAAPKPDRCHHCRQCHRCITRMDHHCPWLMETCIGQRNYKAFVLFLLYTTLLCVLSVETIVRACLRNWPLVPGAEFELPTAWILLLGIGFLVRISVDAVVFLRSLPWSWGLFCCSTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTJ6</accession>
    <name>A8PTJ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRN7-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_0435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732660.1">
        <property type="nucleotide sequence ID" value="XM_001732608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTJ6"/>
    <dbReference type="STRING" id="425265.A8PTJ6"/>
    <dbReference type="GeneID" id="5856966"/>
    <dbReference type="KEGG" id="mgl:MGL_0435"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0435"/>
    <dbReference type="InParanoid" id="A8PTJ6"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP45446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16831" checksum="B3C0AC71AB337F41" modified="2008-01-15" version="1">MPPTRRRVCTVCGSRRFRLIASQLVCYGGHIQRDFRVEAAQDDDGFDSQITTRSRTYYSQSQRDTRRAEKQQRAREKRRKVHGRSNQVFPGSTEHASLPDPEAALLQGPRAMFAMLECYQLVLRKQVESFRKYFHGVCPDAFEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A8PTL8</accession>
    <name>A8PTL8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000001">
        <property type="protein sequence ID" value="EDP45456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732670.1">
        <property type="nucleotide sequence ID" value="XM_001732618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PTL8"/>
    <dbReference type="STRING" id="425265.A8PTL8"/>
    <dbReference type="GeneID" id="5856976"/>
    <dbReference type="KEGG" id="mgl:MGL_0445"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0445"/>
    <dbReference type="InParanoid" id="A8PTL8"/>
    <dbReference type="OMA" id="TPNFFTR"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="28"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP45456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="1112" mass="123147" checksum="69909BD6A83D5B0E" modified="2008-01-15" version="1">MAEGVLPDPARPDHLQNATKLVGTCMDMCPEYERLEREVQKELDRFEMAPGTTSADPRLAVKIYRRPAAGRELPLPEDVRPPAVLQRTLDYLINELLPSDPRDTHFAAVQPFMWNTTRAIRQDFIVQGDRGSIAIACHERIARYHILCLHWKGGEGAEAWSEQQELEQLRKTLRSLMEYYDDQRAVGQTYENEPEFRAYNLLLHARDPEALREVELLPTPVFLAEPLQWALEFRSCIQRSNLLEKRGTPGNTEATPNFFTRAFRSVALPQVSYLMACLAENLFTGIRIGAIKALARAYLPQHHGLPIKFLTRILGMDRDADTTRLLRMLNVEVYEAEAVAKVNRALVLDEDKSFASPFSHTLVETKRGMATCQAIIDGKQALSQPPQPPPPPPVQLPSANLNSLHSFASTSAAPPPKAAATLGAGTPTSLSMFSMPTPKGATVAAGASPSISDGPKPLFSTTSVPSLTTPQRRVFPPTSTPAPSFTFTSPSMPTMSAPPATPTPEQAMSSSAVLSSSTRPDSDIRVPSIPTSGGAPPEQRHASASIPHEPQKSTSLSPQPQPAPPKPRRAVLPQAQLIERLTKSACDKAMRTAVQEVAHSALTAECTRRRQLMRASLLDTVSTRLWQRLQAQPVASQLRAASMDAVARVHRERTMLHTAWIHWRAIYAKVIERKSHAQRLMYLRSQLPQRVREPSAIEGSMTSSTYAQRLSDTERQAAFSKALDRSSRLWECGSMSSAIVERVEWLCDESHECPASWTAAIYAHSESASSRWLRHKLALDHHAQNEYVLQNGRTVVRILDGHLVHVHSPQLVMANGFDQVPSATEPGAALIVIAWSQVEAQAIRRTCKSASWTSMQVLVLDQPQISPDTLLVQALETAIPSLVTTMEQEPVLRTAIQPFWDAWLETCEAMEELLRHTSTSCELAYDAFCALTSLANALLCSIQADAIQGESSYLPYPPRHMGTSVSDTLLMLAIRQLDMLVWIDTGALALLRARVMEHTTSGVFHVARYMQALMSVALTWTWDASAHTPKARADDVARFQQMSSDALTYVASRLPTSTYPRQLESADAHTSLKRPLTPPPTHVSKRIRDDEPSIRLRQLLAQSATLLRTPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUB9</accession>
    <name>A8PUB9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_0647</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732054.1">
        <property type="nucleotide sequence ID" value="XM_001732002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUB9"/>
    <dbReference type="FunCoup" id="A8PUB9">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUB9"/>
    <dbReference type="GeneID" id="5856367"/>
    <dbReference type="KEGG" id="mgl:MGL_0647"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0647"/>
    <dbReference type="InParanoid" id="A8PUB9"/>
    <dbReference type="OMA" id="NWKMHMT"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP44840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="248" mass="26870" checksum="9F570CDDFC5A267F" modified="2008-01-15" version="1">MSRTFFVGGNWKMNGSIEQYQSLIKHLLDSSLDSKAEVVIAPPSLYLLPSQKLLEGKQIALGAQNAYNKPSGAFTGEISVAQLKDASIPWVILGHSERRSIFGETDDMVAQKTSAALETGLSVILCVGESLEQREKNESINVVLGQLETATKDVKDWSKIVIAYEPVWAIGTGKVATAEQAQEVHAAIRQWLVKKADQQVSDTLRIIYGGSVAAKNCKELASQPDIDGFLVGGASLKPEFVDIVNARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUC2</accession>
    <name>A8PUC2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_0650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
            <location evidence="1">Multivesicular body membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732057.1">
        <property type="nucleotide sequence ID" value="XM_001732005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUC2"/>
    <dbReference type="STRING" id="425265.A8PUC2"/>
    <dbReference type="GeneID" id="5856353"/>
    <dbReference type="KEGG" id="mgl:MGL_0650"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0650"/>
    <dbReference type="InParanoid" id="A8PUC2"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0072">Autophagy</keyword>
    <keyword evidence="1" id="KW-0967">Endosome</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="3">
        <location>
            <begin position="38"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="312" mass="34641" checksum="98CBA8F346220B9E" modified="2008-01-15" version="1">MASSQGPIFADKNADTSSNGAKNCDVAHENEQERQSSTYMVFSSAGKLLYLSHDDGAQDWALTQASVMHAMLSLFGMQDQLQRICMNNSVNVSFLHRKPLYLACVAKKKEPDDIVSLRLERVYATIISLISHARLLRLFDRAPNLDLQALIGPMREYVDAVVLNMQSSLALAFGTVPIRPLDASVRDQITRTCAELAPEKRPKQLLYILLWDSDDALISLSHLRRYVPHPTDLALINAVVRVGKDQDGWAPLCLPVFAPNSFAASSRRESLPIAKHCSNTSCAHFVVLHMQLKHALTCRGHDSRLCLGHLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUF7</accession>
    <name>A8PUF7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MGL_0676</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732083.1">
        <property type="nucleotide sequence ID" value="XM_001732031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUF7"/>
    <dbReference type="FunCoup" id="A8PUF7">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PUF7"/>
    <dbReference type="GeneID" id="5856389"/>
    <dbReference type="KEGG" id="mgl:MGL_0676"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0676"/>
    <dbReference type="InParanoid" id="A8PUF7"/>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="197"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EDP44869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="421" mass="46791" checksum="0AA3934DD7C46B5B" modified="2008-01-15" version="1">MVTAAAAAPSHIMAQMQPDKKEKDVAVEQPPPAGVQSFFLSKIQSYELTINEKAQNLRRLEAQRNALNARVRLIHEELQLLQEPGSYVGEVEKVMGKKKVLVKIQPEGKYVVGIAPDIDVTQLKPSLRVALRSDSYTLHKILPNKIDPLVSLMMVEKVPDSTYEMVGGLDRQIKEIKEVIELPVKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRGDDGGNGDSEVQRTMLELLNQLDGFEGTQNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPGPEARVAILRIHSRKMSLQRGINLRVLAEKMGQCSGAEVRGICTEAGMYALRERRQHVSQEDFELAIAKVLKRHTDGSMSVNKLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A8PUP2</accession>
    <name>A8PUP2_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP44928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732142.1">
        <property type="nucleotide sequence ID" value="XM_001732090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PUP2"/>
    <dbReference type="STRING" id="425265.A8PUP2"/>
    <dbReference type="GeneID" id="5856448"/>
    <dbReference type="KEGG" id="mgl:MGL_0735"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0735"/>
    <dbReference type="InParanoid" id="A8PUP2"/>
    <dbReference type="OMA" id="PATENTW"/>
    <dbReference type="OrthoDB" id="3366659at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="245" mass="27731" checksum="7610CAA83A685BC8" modified="2008-01-15" version="1">MAAAQARSMWPQLSVKEDAPVKVLRNSLVVGALGGVSGTVVSVLRASQIEPVVAAWRMSKGWFAFSFGFFVLREYVMQPWTCHVWPMCEQRGHFENIPSTFFSGATIGVLAALWLRRPVVPGAITMSGLCTTVQLGFNELKLGAQRWIEPSHRPDHSESIEVREQTKAPTVRPDDPIHQAQPLHQPSTSSWLSRTKEVLQKHSPIQPITDEDYRKRLEERLREIDAELHLLEEELSERRKVFPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A8PV12</accession>
    <name>A8PV12_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxypeptidase</fullName>
            <ecNumber evidence="8">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_0815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000002">
        <property type="protein sequence ID" value="EDP45008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732222.1">
        <property type="nucleotide sequence ID" value="XM_001732170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PV12"/>
    <dbReference type="GeneID" id="5856528"/>
    <dbReference type="KEGG" id="mgl:MGL_0815"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0815"/>
    <dbReference type="InParanoid" id="A8PV12"/>
    <dbReference type="OMA" id="PYHYGLA"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120516">
        <property type="term" value="F:diacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006521991" description="Carboxypeptidase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP45008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="547" mass="60710" checksum="98C0ED679BE54763" modified="2008-01-15" version="1">MQFRGHLLILISTIFLQIVACVSNSTTSPTSSNRVNGASSSLPSVKSSASSSAFQPLSSSNSTTNSAVPITSSAENSSDSKSSAYNVSALRELLGSNETEEFEIPTRLPNISVEIPPSWGGYQPVSQRPNETRQIYFWMFPATEKVGHDDLIIFFNGGPGCSSLSGVLGEQGPVKLNNVTGKAELNKYSWTNLTNMLWVDQPVGTGFSHGEAKNQSMIEIAKEFNGFLISLYRTFPKLHGKRLWLAGESYAGKFIPFIADQIYKESDQNKKAGINLQGINLSDAFFMNDLVGKELPAMQFARQHYKEMNITEKDMKTLEKKAKKIGINKYIDTHLNYPPKGPLPIPKRFNKSDSVYSAFKQMAKKANPCFSPFYVISSAPCPLNPMGQNITTEKTYKNNYFNLNPSVKPLIHADNVTYVQCSQAKGFKTMQKSKTEFPLHTVLPSVIEKSNRTIILHGMLDYIMLPNGSALAIQNMTWGGKQGFQRPPTQKVMVDNEETGTYQSERKLTFITVDGASHMVAAYKPKPSYKIIQYMLGQISEDQLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVC1</accession>
    <name>A8PVC1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_0833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731565.1">
        <property type="nucleotide sequence ID" value="XM_001731513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVC1"/>
    <dbReference type="FunCoup" id="A8PVC1">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVC1"/>
    <dbReference type="GeneID" id="5855862"/>
    <dbReference type="KEGG" id="mgl:MGL_0833"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0833"/>
    <dbReference type="InParanoid" id="A8PVC1"/>
    <dbReference type="OMA" id="MCVCWSP"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP44351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="391" mass="44214" checksum="C161489D440C6263" modified="2008-01-15" version="1">MDVIVGLSSGDLVWIDPIHYRCTRMNKNGLVSKSPVRQVRWIPFQDTRFLSAHEDGSIYVWDVEREDPPEGFEKKPNDSTWNPKTSIVVEKPDIRSDTSSSGVLKMGRHRDHQPVFYNPVAVWNVSRRPITDMAFSPDAFMLAVTSEDELLHLIDVKREVLVRSFSSYFGGFKCSCWSPDGRFLLTGGQDDLICIWAPHEGHLVARAQGHDSYVSAVAFDPWCYQSSSSFDAYRIISVGEDGRLCLWDFSSSSLHRPRTKPIGTSTTMHTSAFRHSPSNIHIRTQPRADVPMLHPTSTVSMPWCAPCALRIAPYYLIVLRLDGEIDVFSRPKRAAEPPRRLDTTSDFSSRQGFSPRKSDDEPISPDGKAQRHTFRRTLGSPFTRSLRKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVQ4</accession>
    <name>A8PVQ4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_0929</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731661.1">
        <property type="nucleotide sequence ID" value="XM_001731609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVQ4"/>
    <dbReference type="STRING" id="425265.A8PVQ4"/>
    <dbReference type="GeneID" id="5855966"/>
    <dbReference type="KEGG" id="mgl:MGL_0929"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0929"/>
    <dbReference type="InParanoid" id="A8PVQ4"/>
    <dbReference type="OMA" id="MYQNQFP"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022166">
        <property type="entry name" value="UBAP2/Lig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12478">
        <property type="entry name" value="UBAP2-Lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="91"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="548"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="694"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="812"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="593"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP44447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="880" mass="89687" checksum="E45955D58DEC62AF" modified="2008-01-15" version="1">MSMPSSGGTISRRSAPSRRRGPQRQRTAAAANAEDDTEEVRALRAKYPTQLAMLSELFPSWTDEDLLFVISESSGIVEVAVGRISEGHAEQFSSVKSKKTQRKEAAAAAAAATPSVSSSDAHPNTAASGSGPAAASTTTTLTSASATTTPGAAPGAVPDATAGAAITTSVPGSTTTQSLPTHSQTHVAPPIAGAGGVLPEGSRRTGRGGDRSSRGRGASTPAARAGRGGFRGVARGGGVSSAPASAPSAQSRAMPVTTTPAAFGGRPKSSSSSDTKASGTATTPVPGSSSTSARPTTMSWAQIARPAEPKPAATSTATTTSTTTDHHGSLPGADSAATATDAAGAHATPKTDTVLSPDTSATAGAPTPGPTGATEADAPESRPSVSAATLAPAPGPASAFSASASTPSAAAASSVPSRSARPQRPRQDAAVVMPGGTSLDQLDMKFGTLNFMANDSGDVPESGLSTHAGVPLDAKHEDQQPVSDFDAFKSNGFGLDSAYGTSLSTTRPMGQEAASAVDDTSVPLSYGASGNVATTAAGAPQGYSSMYGFDSHERSSHPYTTGLRTSTSADERTGSQVASRPSYDMSGAVSHVPQGATAPQGQPQQPAAMHSHPSQAPHQSSQSQAHQSQQQQQQQQQQQQQQQQQQQQQAQLQAQQQAQQQQPFPNMMPYYYPYYMPNQFQHFSPATGFGQYPLYGAAQPQPPSKLDAPAPSLASYTQPDTMGTPYGTHTPPQPYHSVPSMSMPTYESQGFTQRLAGSHDYKLPGNDSNHSLPGLSFFAAAGAPQGAPAPGRAGAAAGTSSPLDYRAFDASKSPAARPASVSTPGAAGMPPPPPQGMPGQQAPMAAAAQQHPAYYQHYAAGFNQASPYDGYQYGRQPYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVW2</accession>
    <name>A8PVW2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_0969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731701.1">
        <property type="nucleotide sequence ID" value="XM_001731649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVW2"/>
    <dbReference type="FunCoup" id="A8PVW2">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVW2"/>
    <dbReference type="GeneID" id="5856006"/>
    <dbReference type="KEGG" id="mgl:MGL_0969"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0969"/>
    <dbReference type="InParanoid" id="A8PVW2"/>
    <dbReference type="OMA" id="RKNPWMN"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="64"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="641" mass="69455" checksum="948041C79495AC0E" modified="2008-01-15" version="1">MRKLQFRMEQIGFDDTRPDRLLKLEDAELVAAEYNCVVSASEEAAFDIYPRPEPSAEERAKLPLRPPVVTIMGHVDHGKTTLLDTLRSTSVAQGEAGGITQHIGAFSVPVNRPEGAISSVTFLDTPGHAAFSTMRSRGTSVTDIVVLVVAADDSVMPQTREVISLVRDGERKVPLVVAITKIDAPKADPHKVRYDLFAEGVEVEELGGDVPCVEVSAKQKQGLDTLDETLAVLAEMGELRAETSGPAEGRILESRVEKGRGNVATVLVQRGVLQSGDIIACGTTWAKVRQLLQPDGRSAKQVLPGYAAQVAGWRELPKAGDEFLGALDEAKCKRAIEHRKRVLEEQALLYDAEQIDQERRRKAEADALRERTEQMTRKELSRIQRAQEDGSLDADAVAKAVREQRLAAELAAKGDAGASAGAGGKAERAELNLILKGDVSGTVEALAGAVSHIGNAAAGVRIVSQSVGDPTESDVNTAHAIGAHIIGFHVKAPKSIQTSASRCQPPVPLHCDDVIYRLMDHVTDKVAALLPPIDEMRVLGEANVAQLFHIKQGQRRAPKCIAGCRVTNGTVSRANEIRILRGDERKEVFRGRLDTLRQVKKDVSEMRKGTECGMSFDGFDDVQIDDKIQCFTMVQVPATLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVX1</accession>
    <name>A8PVX1_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_0975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731707.1">
        <property type="nucleotide sequence ID" value="XM_001731655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVX1"/>
    <dbReference type="FunCoup" id="A8PVX1">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVX1"/>
    <dbReference type="GeneID" id="5856012"/>
    <dbReference type="KEGG" id="mgl:MGL_0975"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0975"/>
    <dbReference type="InParanoid" id="A8PVX1"/>
    <dbReference type="OMA" id="NFDKTHL"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="297" mass="32066" checksum="64B360EEED797C64" modified="2008-01-15" version="1">MSSTNTAEDLTLKNVLSWFDKNAPTCLADSWDNVGLIAQSPVPKEDDKARGLFLAIDLTPAVAEELLAKPDVRVAIVYHPVIFSPIRSITMQNPLQRSILRCIAAGIHIYCPHTTLDACLGGINDWLVTGLEHAWESSHVPKPESLLRAVQNASYEIIEPSKDDPSVGMGRAHTFAQPCSWAALIHRVKALLRVSHVQIAAASGVNETTQIRSIAVCAGSGGSVLRGWTDADVYVTGEMGHHDILAANARGISVILTNHTNTERRYLVDVLQPALSSSLPGSHVYVSERDADPLCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A8PVX2</accession>
    <name>A8PVX2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_0976</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="8">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="8"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731708.1">
        <property type="nucleotide sequence ID" value="XM_001731656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PVX2"/>
    <dbReference type="FunCoup" id="A8PVX2">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PVX2"/>
    <dbReference type="GeneID" id="5856013"/>
    <dbReference type="KEGG" id="mgl:MGL_0976"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0976"/>
    <dbReference type="InParanoid" id="A8PVX2"/>
    <dbReference type="OMA" id="SHFWTGP"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10880:FF:000005">
        <property type="entry name" value="DUF89-domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="10">
        <location>
            <begin position="64"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="494" mass="56825" checksum="2C3E64105A9C72AE" modified="2008-01-15" version="1">MSDRSHVSARPASKTLLNLGNLPPKPDYFKSDEMFPRTASKIDPNNPPWPAYRGYHEYSFAHETMGKRLPTILGKAIEDVYKTLNQQSDEELIIDLLQCIERMQGLMQALQENQKLRPIVDDNEGDVTLWNKELARYFRGADFMNAPWLFAEAYKYRRLHECFSTSRNWKDYDVFFRQKCDTFGRSGNAVFELSTRFAVPQGSHTEMKEPDLDRQHKLFLELTQVSLWGNATDLSLLVNMTEEDIKKIQSTGGEHLASTEKNILGNHLNRLWALVSRMRGGRIDFVLDNAGFELYCDCVYADWLIQTGIAREVHFHGKRIPWFVSDVTRKDWSWLLNIMTYGALFPDASSKEVESLRTLGKRWKQYEKEGKWVYEQHPFWCSGYTFWELPAEAPDLFHYLCESNLVLFKGDLNHRKLTYDCQAPTSTPFEEAIGPMAKEQGAPPVASLRTIKSDVVVGVPLDVSERLDKEEPGWRISGKYAVVLLSEGSPGEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A8PW03</accession>
    <name>A8PW03_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_0997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731729.1">
        <property type="nucleotide sequence ID" value="XM_001731677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PW03"/>
    <dbReference type="FunCoup" id="A8PW03">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PW03"/>
    <dbReference type="GeneID" id="5856034"/>
    <dbReference type="KEGG" id="mgl:MGL_0997"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_0997"/>
    <dbReference type="InParanoid" id="A8PW03"/>
    <dbReference type="OMA" id="PVIMICT"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfite reductase [NADPH] flavoprotein alpha-component-like FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="248"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41756" checksum="D995754AF5C81E0A" modified="2008-01-15" version="1">MQAQALTLRRLLTVHLDPFSVPRRSFFAVIRHFCPSTHREHEKLTEFLQPGEGTDDMYEYAQRVRRTMAEVLAEFKSVQIPIKYVMEVFPMMRERQYSLASNPSVSTLHRFALLTRPLSAFYQWYPTTLQLAVAVVKYKTRLQKPREGIATSWLARLIPGTCIPVRLQTGTLLPPAHSTTPVLAIGPGTGIAPLRSLVYERLATYLAENNVESHITTNTPTASNPGADECPGTNNQARTTSNHPPTLAETLVIFGCRYQAKDCLYGAEWKQWATTSHANLTYVVAASRDQPEKVYVQHRIRENGARIWDILGPRRGIAYLCGTSGKMPEQVKQSIVDVFVEHGHMNVDQAARYLSTLETERRWQEECW</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWG5</accession>
    <name>A8PWG5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_1092</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731824.1">
        <property type="nucleotide sequence ID" value="XM_001731772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWG5"/>
    <dbReference type="FunCoup" id="A8PWG5">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWG5"/>
    <dbReference type="GeneID" id="5856129"/>
    <dbReference type="KEGG" id="mgl:MGL_1092"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1092"/>
    <dbReference type="InParanoid" id="A8PWG5"/>
    <dbReference type="OMA" id="ADYMRGS"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="358"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP44610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="688" mass="75762" checksum="D7755F6E14CDE31C" modified="2008-01-15" version="1">MVFTPSEIDLKSIATIRTLAADVVANAKSGHPGAPMGLAPLAHLLWSRIMVADPKESHWINRDRFVLSNGHACALQYIMLHLMGYDLTMDDLKAFRQLDSRTPGHPEVHHTDGVEVTTGPLGQGFANAVGLAIAQANAAGTYNKDNFDLFTNRTYVFLGDGCMQEGVASEAASLAGHLRLHNLIAFFDDNHVSIDGDTKCSFTEDVPKRFESYGWNVLVVDNGDSDLQALYDAVVKAWDEKTKPTLVCVRTTIGFGSVNQGKASTHGSPLKDDDIAQLKQKFGFNPDEKFVVPDDVRAAYKSYAEQGAAKRAEWEKMFEEYGRKYENEHKEICRRIAHKLPEGWDQVLPRYEPSDKPMATRKLSELAITKLASVLPEMLGGSADLTGSNLTRWSDATDFQNPSLEIGKYSGRYIRYGVREHAMGAIMNGLCAYGMHIPTAGTFLNFVTYGWGAVRLSSLSNFQVIWVATHDSIGLGEDGPTHQPIEVAAALRALPNMDFWRPADGNEVSAAYKVAIESYKTPSVVSLTRQNLPQLEGSSMEKAEKGGYVLLEDKEAAITLVSTGSEVSICVDAVAKLAEKGIKARVVSIPCFRVFDLQPYDYRISVLPSGHPILSVEAYSTFGWGVYSHVHHGINRFGVSAPYQKAYEKFQLTDHDIADKAVKVVEYYKSMGHIHSPIAVQAAFELQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWI1</accession>
    <name>A8PWI1_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731840.1">
        <property type="nucleotide sequence ID" value="XM_001731788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWI1"/>
    <dbReference type="FunCoup" id="A8PWI1">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWI1"/>
    <dbReference type="GeneID" id="5856145"/>
    <dbReference type="KEGG" id="mgl:MGL_1108"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1108"/>
    <dbReference type="InParanoid" id="A8PWI1"/>
    <dbReference type="OMA" id="IGVMFAH"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="524"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="713"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP44626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="89030" checksum="50481F2AFB7AC12E" modified="2008-01-15" version="1">MPTDRLKAAKTRERDSTSPSATPSTTTASIYPGDASQTEVPSSHAFEPLETLLVRLLDDEERKFFRALDCEVERITRFYNEREHEAVERLSTLVTQLLELAEHRRAYKAQTKRIGNGQLGLKHILSRVPRSLDASEMQRLRLSTQGLEPQDPEDPKAASQDGEDLGNKRREYALEQVQNLRLCPVPSTPPRPATPSMEDHSHQHQYQHDPVHYKAARKKLRTAVIESYRALEILNNYAILNRTGFNKILKKFDKTLETQIWHLYYDARIAKASIVASDTVPRMIHALEEIFANYFEHGNRKRARDLLRAGAAHALMPHDCGHSASTFITGLYLGVALCLTVEGLQGAMKSSTQAQIPLWPQLLVVYSALFLPTLFALLFGLNLIAWQHVRINVVFIFEFDAANALEPVQYFEIPAFFLFLLSLCFFFSFAGNAPEATLLAPTMWPYVWLGTVFGLLVNPLPIMYKSSRRWFVRTCARVLSGGLVGSVEFRDFFIGDELNSIAYSVSNLWLMACEYRAGWIAPNMCVGSASLWTPVLSSAPAFLRLLQCVRRHYDSHGSTCVHLINAAKYASTILHAFSYFAYRTTGSQSTLWFVAWILCATINSSFTSTWDILMDWNLLHADARFPLLRMHLSFDDIWPMYYFAMVSNVAIRFIWIIYLFGTSKSVPIRAFIAASLEMLRRWQWNFLRLENEHVGNADTYKIVRDLPLPYPVQRRPESTADEEDELGIGDNEASRAPSMSQPNVEDQLFASLTETRMHLDQHRQQETTSALGRKGNKAPRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWJ6</accession>
    <name>A8PWJ6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731855.1">
        <property type="nucleotide sequence ID" value="XM_001731803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWJ6"/>
    <dbReference type="FunCoup" id="A8PWJ6">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWJ6"/>
    <dbReference type="GeneID" id="5856160"/>
    <dbReference type="KEGG" id="mgl:MGL_1123"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1123"/>
    <dbReference type="InParanoid" id="A8PWJ6"/>
    <dbReference type="OMA" id="DAETIHM"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="47815" checksum="2A624B8CA6FC8202" modified="2008-01-15" version="1">MHPRPAWASTSGTQQSGSTQSPWNASLLRDLLSTDTGLVETAGHGHHYHRHSRHLPADRLEVERLRDANETQGRVAEPAAIEQLQFHPSHHTHVLLTASRDRRVRLFQVDGKTNPMLESLHVPDLPIKTALFHPSGTSVLIAGPRPYLYAYDIRTGKTLCSSPWRGSGRVVSSAAGTEADAGAERDLSFVRFQPGASSRLVAVGGRRGQVHLLDWGAGAAGQTGGQRVGELRMNAPLAGMAWAAGNGSSGLDGVNEHRLLTLSTEGRIHVWDMRSRSCPVTAYDSGLFGAKGLEVTPSYSMMVPTFWAIGSSNGLVNMYGGADGAQGGADATTSAQLEELLSTSTASSVMDDVRLHARKSLGNLTTATTSMQFSHDAQLLALASRNKKDALRIVHVPTLQTFSNWPTAGTPLGHVTSIDFSTRSEYLAIGNSRGRVLLYSLRSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWM8</accession>
    <name>A8PWM8_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase family 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731887.1">
        <property type="nucleotide sequence ID" value="XM_001731835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWM8"/>
    <dbReference type="FunCoup" id="A8PWM8">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PWM8"/>
    <dbReference type="GeneID" id="5856192"/>
    <dbReference type="KEGG" id="mgl:MGL_1155"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1155"/>
    <dbReference type="InParanoid" id="A8PWM8"/>
    <dbReference type="OMA" id="VCKHGAK"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="3">
        <location>
            <begin position="112"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="413" mass="44164" checksum="B621A14D18BE55E6" modified="2008-01-15" version="1">MSHTHSTFKPLLSQLVQSIPLPEPPSGKLRDPKPSLSRDQLEALLLHLTDVNFTQNPAHHAAIGSALTALRISGIDMQPSTLAFMREKFLDQVQHFDVPEGLKTPASDYTGWVDIVGTGGDGQDTFNVSTTAMFVAGGVDGVHVAKHGGKASSSSSGSAELLLSLGLPLFDVPNDKVVALLPSCSCTFLLAPMFHRAMMPLAPIRASLGFPTLFNILGPLMNPVRPKRGVYGVHSSGLGRIYAETLQMAGMEFFWVVCGEEGLDEISPAGPSHVWEVRQGAVHHRTVSPQDFGIPTHSLDQVRSGSASSNAAIVAYMFTHSDTLPDVPLTEPLHVSCDVPHVKLEPIPAGTNLRAIFDYTILQAAALLYVAGHGQGDLKQCAELARMSILNGKAAGAWHRLHAHMHKAADPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWQ5</accession>
    <name>A8PWQ5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731914.1">
        <property type="nucleotide sequence ID" value="XM_001731862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWQ5"/>
    <dbReference type="STRING" id="425265.A8PWQ5"/>
    <dbReference type="GeneID" id="5856219"/>
    <dbReference type="KEGG" id="mgl:MGL_1182"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1182"/>
    <dbReference type="InParanoid" id="A8PWQ5"/>
    <dbReference type="OMA" id="RYRRYCA"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="768"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="808" mass="90655" checksum="3B80EF2D7B39D560" modified="2008-01-15" version="1">MDVVTEGREPVAVEALGFPLLRLVVEARNEHGLRQQDWSRYRQYCATKTKRVRSALELTHGVTPKAHGKPVSGRRSKRAKRITPTMQSEVDKKRDHTFVRRDIGLDHVTNTRPLELLLFESEHCWAAAEELAATQNEARSSKLRRSSMGRARRAIQYADKLHKLAEALPALTAMSRAQCLAYVGLVRGAYAFLHGNWEQTLRVSAATRCLLTIISECSTTSRDEALASSFLDSLDAQIRFAVYSLGAQDDASERASDYSACEATLPGFHRVTEALKAAHPSSMSSLTPFELHWRAQTIPIHSLELHDVILRVKAEEAALAQFVTPTTKAQTSSQEASGKTTNTASATSKRARLSHAERNAKRRGHAHYTHNSYANRAELDPFDRVLAALTDAESMARVLVDDNSQALAKTHSARYEATGFQLRRVHEWLVYRLLAVRIARNVRLWDDIQSRAAKREMRAKSLVDDRTHRRTRRQKGLAPAVVRAKLSRQYGHSGTRRRARVSRERRLQRALEVAAQQSERRRLRLVPGIAKLLDSIDSSLLAMGGLVMVEGEPDVSSLLEAKRFYYCSELLRQLAGAFTQHGQCAEALVLLQRADLYVRQAQQSLELAHGAEDEDHIFAPHLLASDVLTHQTERLRSMREYAQATVQRQVLPLTPSSSMRSTKGGQSVYYHALRHVSFDQVDLDYALEQARAHANAARVDHDVDGMHTTTDLLAGQEPMALDTANEEEVINNKSTADTVRLVSEEQSVADTRFSNETSVAVAPVPETVPSADSLTAPFDPANAYEEEEELRQERERKSRSWLSWWLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWU4</accession>
    <name>A8PWU4_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731952.1">
        <property type="nucleotide sequence ID" value="XM_001731900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWU4"/>
    <dbReference type="STRING" id="425265.A8PWU4"/>
    <dbReference type="GeneID" id="5856257"/>
    <dbReference type="KEGG" id="mgl:MGL_1220"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1220"/>
    <dbReference type="InParanoid" id="A8PWU4"/>
    <dbReference type="OMA" id="EVFGAMF"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924:SF1">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="122"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP44738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="448" mass="49412" checksum="C4E4E78EBAC69720" modified="2008-01-15" version="1">MNVCTLSTPRCGECRVAVMPSGDATKLVVPSRRKERYLSATCPYVDCRVAIEYQPPTTEAVGALPSTVTTFSVTCVACNRNFDPPGASKMLREVRAQIHTGGKVSSSAKRRIGTDENPLDMTFYDVLGVPANATSDQIKKAYRKLAIKLHPDKNPDDPEGEEKFKTLAAAYHVLSDAELRHKYNEFGPSTPGLVSEDGVVDPEEVFGGLFGGERFHDIIGTISIGRDMKEALQRDSDELAAGAQGEDVEGKDKEKLSPEQAAAKKAEEERIEKVKEERREKRVTALAEKLAHKLSVYVESVKTADNPVLLEEVRNGFQQIIRLEAEELKQENFGVELLHTVGFVYSSKSRHYLASSGMLGSLGGIFHAASSSFHTVRETVSTFRAALELKSVFDELQKAEDEGITEERKKQLEDQAAEKGLRALFKSAKLEVESVIREYHETDTAPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8PWX9</accession>
    <name>A8PWX9_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731987.1">
        <property type="nucleotide sequence ID" value="XM_001731935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PWX9"/>
    <dbReference type="STRING" id="425265.A8PWX9"/>
    <dbReference type="GeneID" id="5856292"/>
    <dbReference type="KEGG" id="mgl:MGL_1255"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1255"/>
    <dbReference type="InParanoid" id="A8PWX9"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP44773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="106" mass="12435" checksum="90BE1BECE7ED6C79" modified="2008-01-15" version="1">MGSYSGLLMSLLVLIAYFYRSAFPIGEGKMTPQDRAYAFFENMLSLVIVLVFFLAYKIYHRTRLVRIEDMDLQTGRREAVPLEVLEQERAEKRSLPLYKKILSFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX07</accession>
    <name>A8PX07_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000003">
        <property type="protein sequence ID" value="EDP44801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001732015.1">
        <property type="nucleotide sequence ID" value="XM_001731963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX07"/>
    <dbReference type="STRING" id="425265.A8PX07"/>
    <dbReference type="GeneID" id="5856320"/>
    <dbReference type="KEGG" id="mgl:MGL_1283"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1283"/>
    <dbReference type="InParanoid" id="A8PX07"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="99" mass="10631" checksum="53080117869599BD" modified="2008-01-15" version="1">MLLSLASSLNSVPLPPVSNRYGIRLPAPEHCLTNVNFSIVPDPPPDAQFGQSFVRPSNGPKESRQDGVPSGAGDTPMADGDENESHGVKRVLEEDEDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX41</accession>
    <name>A8PX41_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MGL_1317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731134.1">
        <property type="nucleotide sequence ID" value="XM_001731082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX41"/>
    <dbReference type="FunCoup" id="A8PX41">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PX41"/>
    <dbReference type="GeneID" id="5855447"/>
    <dbReference type="KEGG" id="mgl:MGL_1317"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1317"/>
    <dbReference type="InParanoid" id="A8PX41"/>
    <dbReference type="OMA" id="THILDIM"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006167">
        <property type="entry name" value="XPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00596">
        <property type="entry name" value="rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="678"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EDP43920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="915" mass="103891" checksum="B5FD11375ED8FC1A" modified="2008-01-15" version="1">MELPPSRHWLLPFHRAILHRLIPDDDELRDLLVVIAPGLGLRRVLSTLLRVYARPTCLVVVVNASSKDVNGINHDLGTLGLGHSAVRDVHHEMSAKQRADVYVSSGIVSVTSRILIVDMLSKRIPISRITGVVVLHAEQVSPVSIEAFILRVYRQENKDGFVKAFSDNVEQLANGFHKLQTIMSQLRLRQVDIWPRFHQDIDKDLVKRRADVIELHQPLTPRMVSIQNAIIECLEGTLHEIRLSKLAADMEDFDVEHTMYRAFDVAVRRQLEPVWHRLSPSTKQLVGDLNTLRHLLHALLSYDSVSFYIYLETILASNAPSTEAGAFQRQSQWLMTDAANIIFHEARARIWGERQECGDTELVLEELPKWKLLVDVLYEIEQDIYTNRSATSNHTILIMAKSDRTVSQLRMWLSLAEGDFKTPGRSYTKACLNDYFAWKKNLQSFQHESPGKDNNENPASSSTASSTLNEALHRKIMRSGAPAHKRRRVRGGLQQGPSRPIVYENEQAAEWKEKVPNIEVARKTSRVLEKSVEEDWVDDSLDYFGLIDLSHVVIVQSYQDDNDDSLLQELRPRYVIMYDPNAQFVRQVEIYRATQEKTPELKIYFLLYTDSVEEQMYLAALRREKDSFERLIREKATMAIPLTVDGTPAEDADQRMVRMLSTRVAGGQRALPSVRPPSVVVDMREFRSSLPSLLHAAGLQVIPCTLQVGDYVISSEMCVERKSLMDLVQSLTSGRLYTQCESMSMHYPYPILLIEFDHERAFTFQGMGETNPTGSARPITSRTSSLDLDLQSKLALLTLSFPRLRLIWSSSPYASVEILSDLKQNYDEPDPAHAAAIGLDDLSERHSQEMAIHATSMEMLRAMPGVTVKNSAYIARKIPHIHSLSDASVTELQGLIGSEPGRKLHDFLHRRFIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A8PX85</accession>
    <name>A8PX85_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MGL_1361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP43964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731178.1">
        <property type="nucleotide sequence ID" value="XM_001731126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PX85"/>
    <dbReference type="STRING" id="425265.A8PX85"/>
    <dbReference type="GeneID" id="5855485"/>
    <dbReference type="KEGG" id="mgl:MGL_1361"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1361"/>
    <dbReference type="InParanoid" id="A8PX85"/>
    <dbReference type="OMA" id="ECCICLL"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="209"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="345"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EDP43964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55144" checksum="38FE3C00555775AB" modified="2008-01-15" version="1">METDTSEGIPANTSSSQPVNPFNLMPRTLGNVFRRYSFSNTNATPAEPSSMHGQASPASSGNHSATYQPPASPSVHRTPRSSHRSATFSFPPRAQKHEDSCNPANDRISAPASESRSGSDSLDLALTEAASTRRMKKIRLTPIIDSTRPLMFFPAELELLEGGPAVQIGRYSEKCLELDADNASEPPYNGADSVSSKATAAKQVMKKPVIIGRHKTYIAFQSKVVSRQHAELWCDLSGRLFLRDTKSSSGTFVNRTRLSPPGVFSRPYELKEGDWIQFGIDFQGGTQDYYRAIKVRFESNYKLDVRPTEYGNNVLRKLQRESPPKTSSTSKSDAPQHNNPGLSECCICLLKIRVSQALFIAPCSHMFHFKCIRPMIMLHHPGFSCPLCRSFHDMDADPQDDTDEENHLTQPNPNSKIVTGNFPRPSKLLPLPPDVRVSEVRETLETNADVTTIELNDMASFISDQSNNVLDDTHDNAFSTPLLEPRTLGQNDSAEGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXD4</accession>
    <name>A8PXD4_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731227.1">
        <property type="nucleotide sequence ID" value="XM_001731175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXD4"/>
    <dbReference type="GeneID" id="5855534"/>
    <dbReference type="KEGG" id="mgl:MGL_1410"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1410"/>
    <dbReference type="InParanoid" id="A8PXD4"/>
    <dbReference type="OMA" id="GTMEQEM"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="585"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="585"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="585"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="631"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="695"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="517"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP44013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="763" mass="83206" checksum="01110A42134C3D9C" modified="2008-01-15" version="1">MLSSESVATGSSHTDTGTEPPSSASPRTPSPILGGGHGIRRSSDDDTAGPADSGQGHLTFPQVGIGLGTMEQEMNMLMDLENLDRDDDTPEFSMSDVADILSQMKDLGYSTPSSSAASTSSAESAPFVRVPRADDADATAQLAQLVWQLARHLQRQEEGRERLRHHLRVTRLASLSLFSSLRISYTHMLQAERDIKARLEVELSGSKSQSKMLSDMVSRASLHQYEDRVHPVDDEAARRAGMPTDTERTKLLADKRYLRQRVKDTEAQVSRLEKELKDLKPLLIRASLDEDVPEFGTPRSRHRHHHSSSSSSGVGGMNMDPLHTNGSNSRRREAVMGDATSEHLILATRMLRTLRHAAPPSSSTDASSSSPSKLDTTPSTPRRARDTYPPRTPKSTERTEDLHTPYAPPSTHSLPSSTYSSGIDDLLHAAQSLAPTNATYYQDSSPTRSPWHRPTHAPLPFSAPVFGSPKRRRVLSMDVDDAPISALDVLANQAVSEHPTSPTYRHSMTSYYPRMMTPRTTSSAPAPAASVPTTATPATTASASTSAGPTSTTSTSSALPLRQTPSAKPKPAHAQSPEKRLPYVRWSSEEDIKLRRAIKEHGQRWEHVARAVGTRSYHQCRQRYLLMRRKEAAAANGSTSPNKSNSTNHPPSHSHPLPNGISGGDSHPHLTSSSSSTLHHYPHAQHPAYNYQHHHPATRASSDTTEHGLPNDTHDEKSSGGASSDNETPALDVHSHLFRTPKAHAPSTMSSLTVHPREQALHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXD7</accession>
    <name>A8PXD7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731230.1">
        <property type="nucleotide sequence ID" value="XM_001731178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXD7"/>
    <dbReference type="STRING" id="425265.A8PXD7"/>
    <dbReference type="GeneID" id="5855537"/>
    <dbReference type="KEGG" id="mgl:MGL_1413"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1413"/>
    <dbReference type="InParanoid" id="A8PXD7"/>
    <dbReference type="OMA" id="VPFHRVM"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000012">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP44016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="180" mass="19451" checksum="EAEF4F1141155918" modified="2008-01-15" version="1">MSVTLHTTLGDIKIEVFCEAVPRAAENFLAHCAAGTYDDVKWHRNMAGFMIQTGDPSGTGKGGQSIWGEPFQDEIRATLKFHARGVVAMANSAPNTNKSQFFITYSKQPHLDGKYTIFGKVIDGAELGGTLELMEKVPVNAKHRPLQDIRMQGVTIHANPIAQRAALATGTSTAAGRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXE7</accession>
    <name>A8PXE7_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_1423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731240.1">
        <property type="nucleotide sequence ID" value="XM_001731188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXE7"/>
    <dbReference type="STRING" id="425265.A8PXE7"/>
    <dbReference type="GeneID" id="5855547"/>
    <dbReference type="KEGG" id="mgl:MGL_1423"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1423"/>
    <dbReference type="InParanoid" id="A8PXE7"/>
    <dbReference type="OrthoDB" id="10689993at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP44026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="709" mass="76956" checksum="23D07E24A4A7B231" modified="2008-01-15" version="1">MNTVNPFSRWWENRQLMEKTRASDATSEPGGHFSEQWRRELASRESSSEVGDYASTRRRDRDRHSNRASSALQSLQRPSSRLGQESPSLVLPEHARKLSSKPRSATSPPSNRNVSYSRLYDQRQSRDARDTSRRSVTPTGANTSQSYLWVPMTKDESIQDASEMGIALTQDASELPLLWQGASSIPNKGPLMSVTEEDESNTSFKYTSTPPREKIAQFSADPRPDTHYPYGDPDSRHAYNMQDLRYPPASVSHNAQNVSTSSTTPTIPSQPESSVEYHGPTNQSTPPPRIERGSMNNDELIRLSWDASALFSSPTDSAPIETLTPQAKAPLFPSPPGAPLTAASTAPVESGPSANIVKTSAPLSASTSDVSPSTRMQSYAQLASFGPAKTLPTSLPLAHDRTGFGKTGDLLSRPGLKPVGLEPAPLLRTLTAPSTSSNSAQKPMDTLPSRFLTASLPFTDKNQDKSRNEPTHMGHSLLRPLDDHRLSAISLTDSIMEDFNPDDAPWMTGSSDVGHMDRSELHGTANEPASASTEPGSRTLSSERANDEQTTVEMPSMPQTPSDAETHHPARRMLDRPRNRGPRPQMMGGIRIAQGQLHAPTPGQTPKRTVSEQTRPKDQAMAPPSGSTETRTFSLSPVARESETTAPSASAGYGHSRHVSDSARESMTLPFNSDNDADDLLADTLMNTMSIDGHLFGSDSLVSPAAKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-06-18" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXG9</accession>
    <name>A8PXG9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MGL_1444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731261.1">
        <property type="nucleotide sequence ID" value="XM_001731209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXG9"/>
    <dbReference type="FunCoup" id="A8PXG9">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXG9"/>
    <dbReference type="GeneID" id="5855568"/>
    <dbReference type="KEGG" id="mgl:MGL_1444"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1444"/>
    <dbReference type="InParanoid" id="A8PXG9"/>
    <dbReference type="OMA" id="EWKMLYA"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000026">
        <property type="entry name" value="Glia maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EDP44047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="140" mass="15767" checksum="E24A1C242616E537" modified="2008-01-15" version="1">MSASTVDIEPSLQSELRSFRLSKSTSKNAALVVKINKPKLLLEKEELIDPITPEELAEELPEHSPRFVLLSYEMKHADGRISYPLVLVYWAPESTNMELSTLYTSALPTFCTLADVGKVIDIRDGNITTEYLNERLGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXW5</accession>
    <name>A8PXW5_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731357.1">
        <property type="nucleotide sequence ID" value="XM_001731305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXW5"/>
    <dbReference type="STRING" id="425265.A8PXW5"/>
    <dbReference type="GeneID" id="5855664"/>
    <dbReference type="KEGG" id="mgl:MGL_1540"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1540"/>
    <dbReference type="InParanoid" id="A8PXW5"/>
    <dbReference type="OMA" id="WIRNDNT"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="10">
        <location>
            <begin position="29"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="908" mass="103510" checksum="57A0B127361451A2" modified="2008-01-15" version="1">MDHTTESGFSDVPLEQLLKELPVEDSDLVPLTVLVERITNNAYQTIQSLSDTLPSLPSGAKRVKIFRTALELRRLFIKLLVIVRWSKDVDLFNRVRNVVALLVEQQWAHEDVFSGLTQVRKIMPNARISDADFVTAIDVLRTGTYRRLPSCIKDSAVSPKPIDNEEALHTLANLDNVLQIRFTCSDYVPMGLRLQCIQDGKAYLEAPDLYKMCLTVSGPEEHDRWWLLDFEFLDKLGQQESLVPNLTEPFLEHVLESAELILSSEYNKEEQSTLMRLHDMLEQEALQRQLHILHHQTQRMAQFSWGKNIRYSLDPMAHILEVYYWVSHSEGMKDKSKLQGRLGLQIVSQPLKGQGRILSDILSGNQSPIHQNNIQVQWHIDPSLQIYLSSKEKECKLECLDMETLLLKCISMHTLALMKHLESDVQSHEGLGAGNPSLCRLCTHNDSGYGPRYSLELRLSDTVHVMMYIPTISGKIGLRLLDRNENRNNMILSLSQSQNATLQRMADQIQADLSSFADTLFTFRLQCLTRSLQLQISWLGLPCSTSIALRSEELKKLSLQNGRPLLYVPLGIVPGYYLMLYFAPDQQLGMAMVLIASVIENGKALQVINSVKWLEKTYLSLFIVSGASLINRSIPPEGDSTAKDRIRTEELELALNYCLAIVVYSHLEEQLRLKLVPFTLVGGTTSSPSSPTSGHDPLLPSLCVQSKKLLPSFEDLVSPNMSLQLCDWWLPSKRRVVISLKVRLNGEFNMEEVQLYDGMVLNLQTGILTFSCYDLTAALIKFQQSWDQIARMCTLINASTIWNQPDFHVSLESLALQQVKFVYGPEGYGKDHKRYTIQVTFEKMDRANLARYTLDFGLQTNDKNHNERKALNPHQHILKILERNLNSLDKNTDIVWQLMFQVRTSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXX0</accession>
    <name>A8PXX0_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731360.1">
        <property type="nucleotide sequence ID" value="XM_001731308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXX0"/>
    <dbReference type="STRING" id="425265.A8PXX0"/>
    <dbReference type="GeneID" id="5855667"/>
    <dbReference type="KEGG" id="mgl:MGL_1543"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1543"/>
    <dbReference type="InParanoid" id="A8PXX0"/>
    <dbReference type="OMA" id="YGMAPTL"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EDP44146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="393" mass="44228" checksum="248C5351756A178F" modified="2008-01-15" version="1">MHDIELNKTETVILFVVVFSVTAVVYFTVAIGVFVPLFVSLTCYRANYTPKAVALTNDENNESTGNTNADLPFVKSIFFRDSVHKLGAPLQGLFSTCKRIHAIEGWRGLYRGTWLVLIQGLVLLIPSMFALYAMYPFNEHTLQNPSPIPFGVAILLELISFVLVLPVDVLKRRTMVHPKRLCWTRPVESLKEVLTAEEYNQPWRLYLLPCVVSTKLLQIFIVNFLAPMGRLALAPSILSGIFVSLVKKRSNSDAISMHWNWFTILLYIIWAFFVLVALLLLDNIYVRATTQRVGPSCAAVQSSRSNSTTTGDSQATVEQHHLSASESEQSEEPIVSLRPCLGNNDPAWTFFGASHVEPYTSIMDMVRKMQNEEGNRSLTRGFMYTVLGHLYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A8PXZ2</accession>
    <name>A8PXZ2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MGL_1557</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731374.1">
        <property type="nucleotide sequence ID" value="XM_001731322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PXZ2"/>
    <dbReference type="FunCoup" id="A8PXZ2">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PXZ2"/>
    <dbReference type="GeneID" id="5855681"/>
    <dbReference type="KEGG" id="mgl:MGL_1557"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1557"/>
    <dbReference type="InParanoid" id="A8PXZ2"/>
    <dbReference type="OMA" id="YFYWIAR"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000004">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="42"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="477"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EDP44160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="525" mass="58037" checksum="92C85599893712FF" modified="2008-01-15" version="1">MLQRRDRALRELTSDEARARAEQHVSRLVAELELERDLSRTILHCDMDMFYAAVELQRRPELAGACFAVGHGVLLTASYEARQFGVRSAMAEFVARAICPNLIVVPAHMDVYKRSSEAVMAVLAKYDAQLYQRSLDEAYLDITSYCAEHGHAHPRDVAAQLRADVLAATGLTVSVGIAPNRLLAKIASDRCKPNGLWYVAPTRQDALAFMHDLSVRKVPGIGQVMERMLQAMSIHTCHDLWERRIELSLCIDSYRMLLASALGIGDAHVTLPARTARRSVGRELTFAPTSDPTHLHAKLRATCEQLERDLATLEYRGRTVSLVGKHDTFERFTRARACPQGVSSFDDLYGVVHALLEQERASFPVPLCLRLIGVRVSSLIDLQVARNGVLAQWLRMPAAAREAASLEPADAASSPTRSSSTSLPLVKVPTSASTSTLPPTPCIPAIVRCPVCGCKVNLRGQPRHARINEHIDACLQQGQAQQQPLSPVQPSPQPRPRPRPRARQPSRRRRPSPASMTLDAYFGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY31</accession>
    <name>A8PY31_MALGO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MGL_1580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731397.1">
        <property type="nucleotide sequence ID" value="XM_001731345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PY31"/>
    <dbReference type="FunCoup" id="A8PY31">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY31"/>
    <dbReference type="GeneID" id="5855704"/>
    <dbReference type="KEGG" id="mgl:MGL_1580"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1580"/>
    <dbReference type="InParanoid" id="A8PY31"/>
    <dbReference type="OMA" id="DDDKAFM"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="225"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="331"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="624"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="874"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="874"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="888"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="928"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EDP44183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="999" mass="114095" checksum="03AC2DB9768343A0" modified="2008-01-15" version="1">MQYVTEDVSDDDEPEDDGDDDGDAEVDEHDDDEDEEQNVEDDFDDDDDDDDDDGEFGGRKTRRRRSRRGGSHTNGWSTAVRMSSRHSTKVTNYADDYHGMSEDDPFEDEVDSYEQETAEPAEQLDQIEGVFGHERDEAFKDDEDDEPTRNMRFVIKWRGYSHLHNTHELYEFLQRFPGAKRVSNYIKAVWQPMHDISTNPHATREDLEALQIQRERQRALLESFRTVERVIAQRDNPPTKEVPYTHTQYLCKWKELGYDQCSWESEDDVAPIARAQIDAYLARATSVTVPSRSESFSRGRPPYVRMTEQPKYIGEHGTLKDFQMTGLNWLAYLWSHAENGILADEMGLGKTVQTVAFFSYLFHTCYQYGPFLVVVPLSTLPSWLSQFEQWAPDMNVVAYTGNSQSREVIREYEFGPPRKMRLNVLLTTYEFILKDRAELMPIKWQFLAVDEAHRLKNAESLLYECLSSFHCAGKLLITGTPLQNNVRELSALLHFLRPDQFDFEVDFDISNVDQNKIQELHERLENVMLRRLKRDVAKELPTKSEQILRVEMSAMQQRMYKAILTRNYSLLSGSHSTQFSLLNIAVELKKASNHPYLFDGVETPTNSREETLRGLIMHSGKMVLLDKLLARLKADNHRVLIFSQMVHMLDILSDYLSLRGYVHQRLDGTVSSDTRKRAIDHFNAPQSPDFCFLLSTRAGGLGINLETADTVIIFDSDWNPQNDLQAMSRAHRLNSKFHINVFRFLTKGTVEEDVLERAKQKMGLEYAIINQMDTSGTNFAPKSLSKSSQNFSREELGAILKFGAQSMFKSDEDGQQKKLDEMDLDDILQHAEARDTEADSNTASSGSQAFLQQFAQVQDFKADDVSWDDIIPSEDRAKAEEEERQRAVESAMAASSSRRRAAVASSEATAHVTATEDGSGDAGTSTTSKSKGNAGNSSSGGKVTRKTSGQRSLELKERDLRVLLRGIQRWGDIRYRYDQIVSEGKLMDKNRSVLMQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A8PY94</accession>
    <name>A8PY94_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MGL_1617</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="AAYY01000004">
        <property type="protein sequence ID" value="EDP44220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731434.1">
        <property type="nucleotide sequence ID" value="XM_001731382.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A8PY94">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PY94"/>
    <dbReference type="GeneID" id="5855741"/>
    <dbReference type="KEGG" id="mgl:MGL_1617"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1617"/>
    <dbReference type="InParanoid" id="A8PY94"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="885"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="16">
        <location>
            <begin position="1573"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="1946"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="352"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="445"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="674"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="799"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1682"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="584"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="751"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EDP44220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="2319" mass="250910" checksum="F28DE10F87A4458C" modified="2008-01-15" version="1">MHASASTPSGGGASDAPSRGGIVEQKVEETKREGAQMCDTISPWLREEDALRTPSTATGEGVLRSSVSKTGPAPSVLMSRVLSSSSSSSSSFSSSSPPPPLPVAPQVSSSTSTSTSSASASEPGSMPAPVPLTVLRQEMGPSTRLGPASTSMSSMQPSVSSPSFSSSQGGDGSHAKTGVSEGGSASREYSQHGQHGQHGQHGQHGQHGQHGLGLRTLNPFSLFRPGSSWRARSHSEDEKRQMTTSTPSGSMRKDKLERTKRLCIPRHGSLSRRVSAELEKNTPALFEPFHRAISLENPVHAGHEHGVTLDTNLDTIGDIIDPSRIGAVPCADAHLNTGSGRCLNQEPPLFPCTEGNGSTTPTGTSSPSSKSSTQGLPATILPTLSEGVRRDSPGSSSLSYGGDVNDERSSSLLSDKPCASCATDSNVSPKALAPALQFPSVPVMPATRTKSSWSPSPPSTSSSAHRPSVSSLHTADLSSRRARQVSMDESLGHRASMGEGPSAQDMRDAMQSPKPPQTPTPSDVRPTQAHSPSAPRPQLLSELQAEAAAQPAARMPLPPAQEQAQYPPSTNPAMSIAPFVMTLSSTTPTGTPSSEVAPPSGSSSSRADVALSSWRAPESWAVVSPSGEQDMKNVVGEYAEDEEPVPPHTSSAGSDHDGSVLSQVVIYEPAMDLSTPPLQTSMRTNPFDEPGTESKRPRFFRRAMSRTPPPAHVPGLGQGITPVHGAGPASSSSWSPSPTSTAGGTGMQLPSGAGTSSAEGAGDASSACTPTTTTTTTTPYSSTKMALMSVGNAAFGRRHRTPHLPFLRSRRGVGSGGMGGGHAGPSPSLSPGPGAGAGAGAGAGPDAVARYVTMHGDAPLPLAARNPPAPLVFRSTDVDPVAPTGKTFMRVYQQNDTYVIISCAVETTASEIAYALGRHATSVADTKGHRLFLYERGTDRPLAPSERPVRIFRRRLIQAGYTDADGLDELGRQDLSFLLRFVYRADRAPTLSIGMLKDQDHTYKHMNLQGMHLTMIPVPVYRCAQWIVSLDLSMNPLTDLPIDFVQLCTSLRMLRLSSLSLKRVPEGVVSIPQLTQIDVSSNRLVDLEHIPLHQLAQLRVIRATNNRLSSAPSYVPSMGALQYLNLSNNRLDTFPARVCAIPNLRDLDLSFNAISIVPSDVHRLTKLERLILVGNSISRLPAEMQSLVSLRVLDVRHTNLHMLGDVMALPRLEYVLASHNYVTSIEGDVGEALKTLDFAHNPLTRAQLSAPVPSSLTRLDLSHANLVTINESLFRSVPELRQLVLDHNQFASLPPLGSLGKLECLSCATNALTQLPDSIGSLRALQRLDVRDNNLRSLPASVWRCQSLRVLNASSNILSSLPMPDGGALDTMPLAASLVHLSVADNRLSDDVFAVLMHLPRLELLNLSMNEIYEVPSGALLALRALRQLFLSSNSLGALPAEDLEALQHLHVLFLNGNKLLSLPAELGRLKQLRAIDAGNNALKYNIANWHYDWNWNANPELRYLNLSGNQRFEIKPKIADVNGREKNLADFNRLHHLRLLGLMEVTMTHQPLPDETDHRRIRTTLAHVNAMPYGIADSIGSHDALQVFDLVVPSFRRDENESLFGLIEGRAHSSLAGTRIARFMTDHCARVLEDELVRLPSSTNAPNDLVPIAIRRAFLRLNQLYAEYILRVHAEHATGSAVRSSSHGSSHSHFHGSNAGAAGATGDASAHTHSSQEVFWGWGSGSSRDMHLWQSSATALLAYQRHRTLYIANIGNAVAVLSRAGGFVRVLGKRHDPLNRDETQRIRAAEGWVSLRNYVNDKTDVARAFGLFQLTPVITACPSVLSIELIDADEFVIIANTELWKFLSYQMAVDIARMDRENPRLAAQKLRDLAIAYGAKDHISVMVVTVAGLFHERLNAHVQNAHASQRGMDSTKKMLRRGRNDLDSTLARLEREVLPPIGQIALVFTDIKNSTLLWETNPSMQSAIRLHNLLLRRQMRSIGGYEVKTEGDAFMVSFQSVSAALLWCFSVQMRLLSIDWPQEILDSPTTQTVYSDDGTLLYRGLSVRMGVHWGCPVCEVDPVNNRMDYFGPMVNRAARISAAADGGQILVSRDVIQELERVFDMYKEHEHLPHTAGSEAAPQSCTPRDVVFLRRLGLGIISVGERRLKGIEAPEHLSLVYPKMLAARYTHLSGARRSSGLFQMYEPTQELLALAQVKQLGYLCLRLESLSNQRCFPGIDPNDPWSNAVYEGRRKPTQPVPSSHRNALVESCIAQTPDMLIVASREDATDAELFPILRQLITRIRNSIHTIALDFARNSMHTPQAQQALSILFDALDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZI6</accession>
    <name>A8PZI6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MGL_1922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730923.1">
        <property type="nucleotide sequence ID" value="XM_001730871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZI6"/>
    <dbReference type="FunCoup" id="A8PZI6">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8PZI6"/>
    <dbReference type="GeneID" id="5855230"/>
    <dbReference type="KEGG" id="mgl:MGL_1922"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1922"/>
    <dbReference type="InParanoid" id="A8PZI6"/>
    <dbReference type="OMA" id="KKTHDMY"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="151"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="372"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EDP43709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="552" mass="62327" checksum="E8B86A49DA1BF2EB" modified="2008-01-15" version="1">MATDEVTKRHRKHKTEDVVDLKEKKAKKEKKEKDRKREEKKKDEKDEKRRKKERKEKKEKETKQEMPDEKHTVEEPEAVPSSGNSGVSASEARAFMEENNITIEMAEESNDKPPRPMLSFDELNGKINPKLKERLDMEGFSKPTLIQSCCWPVLLQGRDMVGVAETGSGKTLAFGIPALQYVMEQWPPSSTSSIKKSKSNNKNKIHVLVIAPTRELAIQTRDNLARVAEPLGYGVFCLYGGVSKGEQIRELASYALPVHIIVGTPGRVLDLAREESLDLGHVSYLTLDEADRMLDKGFEPDIRAIIGMTKTNEDGRRTNMFSATWPPAVRGLADTFMRVPVRVTVGSDVLSANRRVSQTVQVLDDGRAKERALNTFLRTIQAQKTNEKILIFALYKKEAQRVENTLRRWGYRVSGIHGDLSQHDRLASLEAFKTAETPLLVATDVAARGLDIPNVEYVINYTFPLTIEDYIHRIGRTGRGGKSGKAITFFTDEDKAHAGELIRVLKDANQPVPKEMDRFPTTIKRKTHSSYGDHYKELVPGKAKKITFDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A8PZN6</accession>
    <name>A8PZN6_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pcf11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_1935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730936.1">
        <property type="nucleotide sequence ID" value="XM_001730884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8PZN6"/>
    <dbReference type="STRING" id="425265.A8PZN6"/>
    <dbReference type="GeneID" id="5855243"/>
    <dbReference type="KEGG" id="mgl:MGL_1935"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1935"/>
    <dbReference type="InParanoid" id="A8PZN6"/>
    <dbReference type="OMA" id="CRICKEP"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pcf11 C-terminal" evidence="2">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="394" mass="41103" checksum="7D5C2E52F97EBFAE" modified="2008-01-15" version="1">MSSSSSSSSTSVGSTTAATSSYVLPQTASLETASPALASPLGPAPLASITPVVGAGGPASGIASASASLSSAAPASASELIANLMKVGLLPSSSAAQVPATSEPSAVGAGSTPSQDKAYTDYIMSLDLSMVTADLSKPAPELEILLQEHLPHPCRQCANRYPGGEAGKHSLDDHLDWHFTNNRRARATLARGQSRAWLDPAVRWVRSGFDDVMPTSKDAHQWDLDDPAAEKALREKMAHAFVIVPHGSELASRPCRICKEPFQSEWSEEVEEWIWRNAVLIDGEYYHASCYYSAKSMSDVVSATRLAATAASAATALSATAAIHAPSSPGKAEQNAHCDVAGDVAGDADADLDAQRKRKATSPPPMVEPSPSSSATNPPPHKKPSIVKEEHACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q003</accession>
    <name>A8Q003_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WDR5-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1967</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730968.1">
        <property type="nucleotide sequence ID" value="XM_001730916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q003"/>
    <dbReference type="STRING" id="425265.A8Q003"/>
    <dbReference type="GeneID" id="5855275"/>
    <dbReference type="KEGG" id="mgl:MGL_1967"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1967"/>
    <dbReference type="InParanoid" id="A8Q003"/>
    <dbReference type="OMA" id="CKGHDTA"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="4">
        <location>
            <begin position="37"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="332" mass="36111" checksum="CA0C06CDA25E0B03" modified="2008-01-15" version="1">MASESVQDTLDAGDVQGALNAPDAQDPDAYSLLYMMYGHSKSVTSIAFSYDGQKIATGGADKLVNIWQVHTGRMLHTLEGHTHGVNGVCWTRDSAYVASVSDDRSVRLWDAESGHLVRTFLGHTSYVMCVACHPLSTLLISGGFDETIRMWDIQRGTCHREIAAHSEAVTCVDFCMDGTMIASSSYDGLIRLWDTSSGLCLRTLQHTDQAPVASVQFSPSSLQLLASSLDSAVRLWDIANARILKTYTSHKNTQYAGTGILVFRPSRTCVACGSEDRLVYVWDVQTKRVVCKLAAHRDAVICVAAHPTLPILASAGLAQDASVALWVDRRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0L2</accession>
    <name>A8Q0L2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MGL_2049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731050.1">
        <property type="nucleotide sequence ID" value="XM_001730998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0L2"/>
    <dbReference type="STRING" id="425265.A8Q0L2"/>
    <dbReference type="GeneID" id="5855357"/>
    <dbReference type="KEGG" id="mgl:MGL_2049"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2049"/>
    <dbReference type="InParanoid" id="A8Q0L2"/>
    <dbReference type="OMA" id="XNKERER"/>
    <dbReference type="OrthoDB" id="273141at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EDP43836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="123" mass="13903" checksum="CBD5288F436B9CB8" modified="2008-01-15" version="1">MPQADSDAMSTLDQRAYGKQLLPGEGAAMASYVQEGKRIPRRGEIGLSAEQIAAFERAGFVMSGSRHQRMNAVRVRKENQVISAEERQSELHQKRQDRARKEADIIAQFREMVDMLQQQQSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q0S9</accession>
    <name>A8Q0S9_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MGL_2077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001731078.1">
        <property type="nucleotide sequence ID" value="XM_001731026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q0S9"/>
    <dbReference type="STRING" id="425265.A8Q0S9"/>
    <dbReference type="GeneID" id="5855385"/>
    <dbReference type="KEGG" id="mgl:MGL_2077"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_2077"/>
    <dbReference type="InParanoid" id="A8Q0S9"/>
    <dbReference type="OMA" id="MARMPRG"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="68"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EDP43864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="317" mass="35491" checksum="7E12376F21B3EBC2" modified="2008-01-15" version="1">MSSVLGRGLRTCVQIPILSYSKAPKLRTLTQKMSSASSSASVMSSLPSFYERTPIPNDPTRPFVRSAACLIIGDEVLNGKTHDTNSNKMAKMCFEMGIELKRVEVIADDEKEIVEAVQRMSRNYDWVVTSGGIGPTPDDITYESIAKAFGKEPLEYNDETLRRMEIAIRHRYKDIPDTDDVREAQKRMALFPRESEVIFPTEQLWVPVVRVNGNVCILPGIPSLFEALLHAMQPYLHLDPNMPRPIRCLIQTSLPESVISPLLKRLTLSGKKDGIRVGSYPKWDKGVHISLIGFDQALIDQYAQQVMQETGGQLASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q149</accession>
    <name>A8Q149_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septicolysin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MGL_1735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730736.1">
        <property type="nucleotide sequence ID" value="XM_001730684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q149"/>
    <dbReference type="GeneID" id="5855434"/>
    <dbReference type="KEGG" id="mgl:MGL_1735"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1735"/>
    <dbReference type="InParanoid" id="A8Q149"/>
    <dbReference type="OrthoDB" id="4009151at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12208">
        <property type="entry name" value="DIP1984-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047741">
        <property type="entry name" value="DIP1984-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038048">
        <property type="entry name" value="DIP1984_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20935">
        <property type="entry name" value="DUF6847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EDP43522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17955" checksum="ED76D8B683827D57" modified="2008-01-15" version="1">MLLAEALAERAEAQRRYEQLMQRLLRVVRVQEGDEPVEDPEELLVSANGILDRMDWLIRCVNKTNTQTMFDDKHTLTDAIAFRDMALKRRKLYSDVATKASTSQDRYTRSEIKYVSVIDVRKMQKQVDKLAGEYRTLDTRIQKMNWEVGLIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q159</accession>
    <name>A8Q159_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MGL_1739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730740.1">
        <property type="nucleotide sequence ID" value="XM_001730688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q159"/>
    <dbReference type="STRING" id="425265.A8Q159"/>
    <dbReference type="GeneID" id="5855047"/>
    <dbReference type="KEGG" id="mgl:MGL_1739"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1739"/>
    <dbReference type="InParanoid" id="A8Q159"/>
    <dbReference type="OMA" id="NLIYCEL"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="7">
        <location>
            <begin position="138"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EDP43526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="659" mass="72837" checksum="135A0D3E2788C908" modified="2008-01-15" version="1">MGTKRKAKPAVDFKKTKPKLGKGKQPASNATDTSFKAKAIAMPQQSIMLDRSQTATTRRRQTLNDLIQQTHHPSSGARKDAVMGMLELVTTYQGFLEQNTTSLINTALPLIGDDDVHVRAAIARYFTNLLASIPDDTFAPYASSMLLMTSSAMSHISMFVRIDALQILSLLLDKVPSIATQDWESALDAKHSSDSHGQRILQAFFAMLGVAAGAQRARSGLVATSLSTTSVNLSASQRLTVLRSLYKFLCQAMRDSQSHGMPLWCFQSAFASPSDLEQFEQLFHHSSLEAHPWTIAHVPGASTHVVFENLMSAARVDQSVDAAPESIHERLAHVLHASLLSTLLDSLPAALAPDGSSSDVHADLVMHLLRIYLLLWRRIITLHIKTRATQGTNDVPIKSITQLEQLLAHLGPYFTGSIDGPHVRLELHVIYCELVSLCTMAAHERAPSKHLPSVLAFLQTLLTQNHAALTHNLYQALLPTFWLVLSTPIDGNVDILFALLAHFDTVQNRALHMVAFHFLARIAMLPTFRSLQVQVLPLYTPSLRAAWHTWILSLPRLLWQSATYAVSSRTSSSSEEEARAALTLAQHILEFLHCTLLPARHPLFEHEALVTELAPRVAPLFHVHHPKRGIVPGPYRKLPVPTQRMAEAVVQLIPISPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1B2</accession>
    <name>A8Q1B2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="13">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">MGL_1761</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="13"/>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730762.1">
        <property type="nucleotide sequence ID" value="XM_001730710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1B2"/>
    <dbReference type="FunCoup" id="A8Q1B2">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1B2"/>
    <dbReference type="MEROPS" id="C19.A65"/>
    <dbReference type="GeneID" id="5855069"/>
    <dbReference type="KEGG" id="mgl:MGL_1761"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1761"/>
    <dbReference type="InParanoid" id="A8Q1B2"/>
    <dbReference type="OMA" id="FVPCEHT"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="17">
        <location>
            <begin position="90"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="241"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="507"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="15">
        <location>
            <begin position="566"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="653"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EDP43548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="699" mass="77156" checksum="7A740AF9CE3A83FE" modified="2008-01-15" version="1">MHYQKTGHALALWIRRTPKPAEPVTRLAVVERAEEDQYNYERHPVCLACDPVHGRRIQNTEAVQAVANGIVNATSSAHKIEVQAWEEDIVPCQHTQELRQDITSPPLLGKDAACSRCELDTNLWMCLQCGHLGCGRAQFGGIQGHSHALAHFEQTGHPCSVKQGTITPEGTGDVYCYACNDARIDPNLNAHLQRLGVPVATLSKTEKSMTELQLEQNISFEFSMVDENGNTMKPAYGPGRTGIQNLGNSCYMASVLQAVWSLPTVRHRYASIECHAVSCTEHPAQCFECQLRKLTYGLVSGRYATGEKPRGIKPSMFKSLMGQGHPEFASMRQQDAEEFLQHLVTRLGNESSRTQSENPTRVFSYVLEHRLQCNSCHKVRYTEEPVEACVGLPVPVKETSEAGVYEPVSFAESLDAYTAAETLEYSCPSCGTCVEATKQTRFATLPDVLVVQAQRFQLIHWVPQKVPVPFKVPLSQSMDLSAYLGKGLQIGEEELPEDSNSTGVNTRPAEKVIAPDALATLVSFGFNETQAQHAWQATDGDLEASANWLFEHGDEVNTIEPPAATATNPDVSTLEDMGFTRAQAKKAMRLQGNVEMAVSWLFEHPDDAGDLDIPKEEKRQSGTAARAGSRDAPANYELTSFVTHRGPSVHSGHYVAHVKDGNDWVFFNDEKVMHAPIHGTPSSVGALSEMAYLYFFRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-02-05" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1G0</accession>
    <name>A8Q1G0_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MGL_1782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730783.1">
        <property type="nucleotide sequence ID" value="XM_001730731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1G0"/>
    <dbReference type="GeneID" id="5855090"/>
    <dbReference type="KEGG" id="mgl:MGL_1782"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1782"/>
    <dbReference type="InParanoid" id="A8Q1G0"/>
    <dbReference type="OMA" id="CLTHDER"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EDP43569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <sequence length="339" mass="37295" checksum="8029E836468E3C50" modified="2008-01-15" version="1">MSDADGIDLVQEHHERSAHVDESLGRYSAYTMRLKTLVTSVSRYIAYTSDVGEAFRPLTRPIVVTSAYAISWAYIFTDVGWTCWQAAKLQDRDSPTLASDIAWIAARRGAFQSLASLVLPAVTIHSVVKHSAHLFAKFKSSRVRVAGPTAAGLLVVPLLPIVFDDPVETVVERVFDALEYRLAAYRGDVHARMSLEKGSLLHGYHIPAADESHEHGVDPSLAAQLAILGVGVDLVHVPRMRQLVARHARRVHALSFEPLAAAAPSWMRASRTPTDDGPLASTSSSDTVSASLSLRMAAQHFARRTLSQKEWDSFVSAPCLTHDERLRFLATRYAGHCRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1L2</accession>
    <name>A8Q1L2_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GCF C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MGL_1805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730806.1">
        <property type="nucleotide sequence ID" value="XM_001730754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1L2"/>
    <dbReference type="STRING" id="425265.A8Q1L2"/>
    <dbReference type="GeneID" id="5855113"/>
    <dbReference type="KEGG" id="mgl:MGL_1805"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1805"/>
    <dbReference type="InParanoid" id="A8Q1L2"/>
    <dbReference type="OMA" id="HAHIMAD"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="272"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EDP43592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="84013" checksum="4A722226C840829C" modified="2008-01-15" version="1">MADRRALQAALQERYGNQDALSSATSAAEATTVASARKKREHMRRAAVAALSSVPSEDEDGYIPLTGSRPQHTRRHESRLPREEDELDNGEDEHAQHTAASERIALGPSAERQRKLDRRRHLRSFLASAKSGVDANDASRNRNTNSDDVDDIEIIVRRPRATAKSVQPSPAQIHEEDAFAMSEDAMSMYRGADVCGASNAINVMSSSRAAMDVDDMDEDESEAQEAWEQAQMRRVHVAHDAPSEGSPTKFEEAHVPAAVPLVSALPTPNSCMTRLEQRLVHLEQSAADHQQHAEDTQTTLRTLAEEESTLKVEADALERKAAWFTDMKKYVDALAGFLDTKMPMLETLEHNALALLVDRCLTRQRARALAWEDDIALVHGASGASLWIARPGTSEELRRLDSDGAWNSAIRADRRRRIQEGVTDSSAQWLDDDEKAHFNDGHQQLCLEHEQVMKDVQALAFRAPDACVPDSMVSRFDVWRKTFPDEYHMAWGGLALANAWEFYARYELVLWDALWCPTTSAGDVCLGGSPEGIPGFAWEQAVSKYVEAGHAGSANHCDKGQTVQGVSSSGTGGDDEITSTLVAKTVVPKLMALAQNGAYDPFSAAETQAALDVIEQVSYVLEPTHWQFQALVQAFRNAVTPHVHVLANALRATPTFAGAPMHPDGPPARIRLVKAITTLTCHIFRWSTYWVGPHALPWNDASEVAEMEALATEAVTCAWSQIEQAAALQPVADIAQTLLHVWPTTVAIDLRHACEAYVQTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-01-15" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A8Q1L7</accession>
    <name>A8Q1L7_MALGO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MGL_1807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)</name>
        <name type="common">Dandruff-associated fungus</name>
        <dbReference type="NCBI Taxonomy" id="425265"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Malasseziomycetes</taxon>
            <taxon>Malasseziales</taxon>
            <taxon>Malasseziaceae</taxon>
            <taxon>Malassezia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2007" name="Proc. Natl. Acad. Sci. U.S.A." volume="104" first="18730" last="18735">
            <title>Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.</title>
            <authorList>
                <person name="Xu J."/>
                <person name="Saunders C.W."/>
                <person name="Hu P."/>
                <person name="Grant R.A."/>
                <person name="Boekhout T."/>
                <person name="Kuramae E.E."/>
                <person name="Kronstad J.W."/>
                <person name="Deangelis Y.M."/>
                <person name="Reeder N.L."/>
                <person name="Johnstone K.R."/>
                <person name="Leland M."/>
                <person name="Fieno A.M."/>
                <person name="Begley W.M."/>
                <person name="Sun Y."/>
                <person name="Lacey M.P."/>
                <person name="Chaudhary T."/>
                <person name="Keough T."/>
                <person name="Chu L."/>
                <person name="Sears R."/>
                <person name="Yuan B."/>
                <person name="Dawson T.L.Jr."/>
            </authorList>
            <dbReference type="PubMed" id="18000048"/>
            <dbReference type="DOI" id="10.1073/pnas.0706756104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC MYA-4612 / CBS 7966</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAYY01000006">
        <property type="protein sequence ID" value="EDP43594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001730808.1">
        <property type="nucleotide sequence ID" value="XM_001730756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A8Q1L7"/>
    <dbReference type="FunCoup" id="A8Q1L7">
        <property type="interactions" value="770"/>
    </dbReference>
    <dbReference type="STRING" id="425265.A8Q1L7"/>
    <dbReference type="GeneID" id="5855115"/>
    <dbReference type="KEGG" id="mgl:MGL_1807"/>
    <dbReference type="VEuPathDB" id="FungiDB:MGL_1807"/>
    <dbReference type="InParanoid" id="A8Q1L7"/>
    <dbReference type="OMA" id="VNKADMM"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000008837">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="397"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="2
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